{"text_format":"3","workbook":"xls","n_sheets":1,"sheets":["Data file 16"],"read":"whole","date_system":"1900","formulas":"cached_only"}

{"sheet":"Data file 16","index":0,"n_rows":24,"n_cols":5,"rows_kept":24,"merged":[[0,0,0,4],[2,2,2,3]],"flags":["formulas_cached_only"]}
["Additional data file 16: Characteristics of the samples used from the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS). The samples were categorized according to their individual risk scores. These risk scores are the product of the methylation profile with the regression coefficients of the signature. The statistical significance was assessed by a two-sided, Fisher's exact test. The missing values were not included in the analysis."]
[]
["FACTORS",null,"METHYLATION SIGNATURE",null,"P value"]
[null,null,"positive","negative"]
["Grade","1 or 2",47,37,1]
[null,3,19,14]
["Histology","invasive ductal",49,37,0.29]
[null,"others",15,6]
["PR","positive",35,29,0.764]
[null,"negative",8,5]
["Nodes","positive",14,21,0.04]
[null,"negative",46,28]
["Size","<=2cm ",38,38,0.06]
[null,"> 2cm ",24,10]
["Time to diagnosis","<=2 years",35,27,1]
[null,"> 2 years",32,25]
["Surgery","yes",20,14,0.419]
[null,"no",42,43]
["Radiotherapy","yes",32,33,0.098]
[null,"no",35,19]
["Anti-endocrine therapy","yes",37,36,0.18]
[null,"no",12,5]
["Chemotherapy","yes",9,3,0.212]
[null,"no",40,38]