{"text_format":"3","workbook":"xls","n_sheets":13,"sheets":["Figure 1","Figure 2","Figure 3","Figure 4","Figure 5","Figure 6","Figure 7","Figure S11","Figure S12","Figure S14","Figure S16","Figure S17","Figure S18"],"read":"whole","date_system":"1900","formulas":"cached_only"}

{"sheet":"Figure 1","index":0,"n_rows":62,"n_cols":7,"rows_kept":62,"merged":[[1,0,1,6],[16,0,16,6],[31,0,31,6],[38,0,38,6],[45,0,45,6],[52,0,52,6],[59,0,59,6]],"flags":["formulas_cached_only"]}
[]
["Figure 1g"]
["Comparison","Mean Diff.","95.00% CI of diff.","P Value Summary","Adjusted P Value","Cohen's d","Hedges' g"]
["D0 vs. D3",37.19,"24.87 to 49.51","****","<0.0001",{"v":8.27623544418156,"d":"8.28"},{"v":11.0349805922421,"d":"11.03"}]
["D0 vs. D7",26.74,"14.41 to 39.06","***",0.0001,{"v":5.95070007468176,"d":"5.95"},{"v":7.93426676624235,"d":"7.93"}]
["D0 vs. D14",16.15,"3.830 to 28.48","**",0.0086,{"v":3.59400920740877,"d":"3.59"},{"v":4.79201227654502,"d":"4.79"}]
["D0 vs. D21",10.61,"-1.711 to 22.94","ns",0.1078,{"v":2.36114165266917,"d":"2.36"},{"v":3.14818887022556,"d":"3.15"}]
["D0 vs. D28",-8.344,"-20.67 to 3.980","ns",0.2752,{"v":-1.8568676672829,"d":"-1.86"},{"v":-2.47582355637719,"d":"-2.48"}]
["D3 vs. D7",-10.45,"-22.77 to 1.872","ns",0.1156,{"v":-2.32553536949979,"d":"-2.33"},{"v":-3.10071382599972,"d":"-3.10"}]
["D7 vs. D14",-10.59,"-22.91 to 1.739","ns",0.1091,{"v":-2.356690867273,"d":"-2.36"},{"v":-3.14225448969733,"d":"-3.14"}]
["D7 vs. D21",-16.13,"-28.45 to -3.802","**",0.0087,{"v":-3.5895584220126,"d":"-3.59"},{"v":-4.7860778960168,"d":"-4.79"}]
["D7 vs. D28",-35.08,"-47.41 to -22.76","****","<0.0001",{"v":-7.80667758488543,"d":"-7.81"},{"v":-10.4089034465139,"d":"-10.41"}]
[]
[]
[]
[]
["Figure 1h"]
["Comparison","Mean Diff.","95.00% CI of diff.","P Value Summary","Adjusted P Value","Cohen's d","Hedges' g"]
["D0 vs. D3",-6.028,"-15.04 to 2.988","ns",0.2864,{"v":-1.83377100962456,"d":"-1.83"},{"v":-2.44502801283275,"d":"-2.45"}]
["D0 vs. D7",-23.76,"-32.78 to -14.75","****","<0.0001",{"v":-7.22800251968807,"d":"-7.23"},{"v":-9.63733669291742,"d":"-9.64"}]
["D0 vs. D14",-21.38,"-30.40 to -12.37","****","<0.0001",{"v":-6.50398543227823,"d":"-6.50"},{"v":-8.67198057637098,"d":"-8.67"}]
["D0 vs. D21",-16.19,"-25.21 to -7.178","***",0.0006,{"v":-4.92514144754839,"d":"-4.93"},{"v":-6.56685526339786,"d":"-6.57"}]
["D0 vs. D28",-14.07,"-23.08 to -5.052","**",0.0022,{"v":-4.28021866380518,"d":"-4.28"},{"v":-5.70695821840691,"d":"-5.71"}]
["D3 vs. D7",-17.73,"-26.75 to -8.718","***",0.0003,{"v":-5.39362309234299,"d":"-5.39"},{"v":-7.19149745645732,"d":"-7.19"}]
["D7 vs. D14",2.38,"-6.636 to 11.40","ns",0.9427,{"v":0.724017087409832,"d":"0.72"},{"v":0.965356116546442,"d":"0.97"}]
["D7 vs. D21",7.568,"-1.448 to 16.58","ns",0.1211,{"v":2.30225265441916,"d":"2.30"},{"v":3.06967020589222,"d":"3.07"}]
["D7 vs. D28",9.694,"0.6777 to 18.71","*",0.0327,{"v":2.94900069132391,"d":"2.95"},{"v":3.93200092176521,"d":"3.93"}]
[]
[]
[]
[]
["Figure 1k"]
["Comparison","Mean Diff.","95.00% CI of diff.","P Value Summary","P Value","Cohen's d","Hedges' g"]
["LPC vs. PBS","18.98 ± 3.288","11.55 to 26.42","***",0.0003,"−3.496","−3.196"]
[]
[]
[]
[]
["Figure 1l"]
["Comparison","Mean Diff.","95.00% CI of diff.","P Value Summary","P Value","Cohen's d","Hedges' g"]
["LPC vs. PBS","-0.2707 ± 0.06702","-0.4224 to -0.1191","**",0.0029,{"v":2.445,"d":"2.45"},2.23]
[]
[]
[]
[]
["Figure 1m"]
["Comparison","Mean Diff.","95.00% CI of diff.","P Value Summary","P Value","Cohen's d","Hedges' g"]
["LPC vs. PBS","0.1400 ± 0.03945","0.05076 to 0.2292","**",0.0062,{"v":-2.149,"d":"-2.15"},{"v":-1.965,"d":"-1.97"}]
[]
[]
[]
[]
["Figure 1n"]
["Comparison","Mean Diff.","95.00% CI of diff.","P Value Summary","P Value","Rank-biserial","r"]
["LPC vs. PBS","/","/","ns",0.5455,{"v":0.2,"d":"0.20"},-0.165]
[]
[]
[]
[]
["Figure 1o"]
["Comparison","Mean Diff.","95.00% CI of diff.","P Value Summary","P Value","Rank-biserial","r"]
["LPC vs. PBS","/","/","ns",0.6623,"−0.20","−0.165"]

{"sheet":"Figure 2","index":1,"n_rows":19,"n_cols":7,"rows_kept":19,"merged":[[1,0,1,6],[12,0,12,6]],"flags":["formulas_cached_only"]}
[]
["Figure 2f"]
["Comparison (LPC vs. PBS)","Mean Diff.","95.00% CI of diff.","P Value Summary","Adjusted P Value","Cohen's d","Hedges' g"]
["1.25psi",18.97,"13.36 to 24.59","****","<0.0001",{"v":3.64884786411452,"d":"3.65"},{"v":4.86513048548603,"d":"4.87"}]
["2.50psi",16.42,"6.992 to 25.84","**",0.0022,{"v":1.88322762761691,"d":"1.88"},{"v":2.51097017015587,"d":"2.51"}]
["3.75psi",18.54,"9.489 to 27.59","***",0.0006,{"v":2.21772650671448,"d":"2.22"},{"v":2.9569686756193,"d":"2.96"}]
["5.00psi",16.79,"8.131 to 25.44","**",0.0011,{"v":2.12597102238691,"d":"2.13"},{"v":2.83462802984921,"d":"2.83"}]
["6.25psi",23.1,"15.38 to 30.83","****","<0.0001",{"v":3.25904416816467,"d":"3.26"},{"v":4.34539222421956,"d":"4.35"}]
[]
[]
[]
[]
["Figure 2g"]
["Comparison (LPC vs. PBS)","Mean Diff.","95.00% CI of diff.","P Value Summary","Adjusted P Value","Cohen's d","Hedges' g"]
["1.25psi",0.9873,"0.1254 to 1.849","*",0.0254,{"v":1.15120877433907,"d":"1.15"},{"v":1.5349450324521,"d":"1.53"}]
["2.50psi",1.667,"0.8048 to 2.529","***",0.0003,{"v":1.94375066020787,"d":"1.94"},{"v":2.59166754694383,"d":"2.59"}]
["3.75psi",2.149,"1.287 to 3.011","****","<0.0001",{"v":2.50577094708261,"d":"2.51"},{"v":3.34102792944349,"d":"3.34"}]
["5.00psi",2.111,"1.249 to 2.973","****","<0.0001",{"v":2.46146229376054,"d":"2.46"},{"v":3.28194972501405,"d":"3.28"}]
["6.25psi",2.403,"1.541 to 3.265","****","<0.0001",{"v":2.80193931402491,"d":"2.80"},{"v":3.73591908536654,"d":"3.74"}]

{"sheet":"Figure 3","index":2,"n_rows":65,"n_cols":7,"rows_kept":65,"merged":[[1,0,1,6],[10,0,10,6],[19,0,19,6],[28,0,28,6],[37,0,37,6],[45,0,45,6],[53,0,53,6],[61,0,61,6]],"flags":["formulas_cached_only"]}
[]
["Figure 3c"]
["Comparison (pre - after)","Mean Diff.","95.00% CI of diff.","P Value Summary","Adjusted P Value","Cohen's d","Hedges' g"]
["Vehicle",0.05,"-8.545 to 8.645","ns",">0.9999",{"v":0.00895116696418024,"d":"0.01"},{"v":0.0119348892855737,"d":"0.01"}]
["Carbamazepine",16.84,"8.886 to 24.80","***",0.0001,{"v":3.01452063885146,"d":"3.01"},{"v":4.01936085180194,"d":"4.02"}]
["Pregabalin",11.03,"2.439 to 19.63","*",0.0105,{"v":1.97462743229816,"d":"1.97"},{"v":2.63283657639755,"d":"2.63"}]
[]
[]
[]
[]
["Figure 3d"]
["Comparison (pre - after)","Mean Diff.","95.00% CI of diff.","P Value Summary","Adjusted P Value","Cohen's d","Hedges' g"]
["Vehicle",2.167,"-5.823 to 10.16","ns",0.8597,{"v":0.417317556148739,"d":"0.42"},{"v":0.556423408198318,"d":"0.56"}]
["Carbamazepine",18.24,"10.85 to 25.64","****","<0.0001",{"v":3.51213620495866,"d":"3.51"},{"v":4.68284827327821,"d":"4.68"}]
["Pregabalin",6.1,"-1.890 to 14.09","ns",0.1663,{"v":1.17472869981878,"d":"1.17"},{"v":1.56630493309171,"d":"1.57"}]
[]
[]
[]
[]
["Figure 3e"]
["Comparison (pre - after)","Mean Diff.","95.00% CI of diff.","P Value Summary","Adjusted P Value","Cohen's d","Hedges' g"]
["Vehicle",0.06667,"-1.077 to 1.211","ns",0.9982,{"v":0.0896621067944848,"d":"0.09"},{"v":0.11954947572598,"d":"0.12"}]
["Carbamazepine",1.886,"0.8265 to 2.945","***",0.0007,{"v":2.53612428803438,"d":"2.54"},{"v":3.3814990507125,"d":"3.38"}]
["Pregabalin",0.9333,"-0.2107 to 2.077","ns",0.1292,{"v":1.25516190597409,"d":"1.26"},{"v":1.67354920796546,"d":"1.67"}]
[]
[]
[]
[]
["Figure 3f"]
["Comparison (pre - after)","Mean Diff.","95.00% CI of diff.","P Value Summary","Adjusted P Value","Cohen's d","Hedges' g"]
["Vehicle",0.3167,"-1.268 to 1.901","ns",0.9368,{"v":0.307460619223734,"d":"0.31"},{"v":0.409947492298312,"d":"0.41"}]
["Carbamazepine",2.714,"1.247 to 4.182","***",0.0005,{"v":2.63475121885332,"d":"2.63"},{"v":3.51300162513776,"d":"3.51"}]
["Pregabalin",1.2,"-0.3848 to 2.785","ns",0.1713,{"v":1.1649912948168,"d":"1.16"},{"v":1.5533217264224,"d":"1.55"}]
[]
[]
[]
[]
["Figure 3i"]
["Comparison (pre - after)","Mean Diff.","95.00% CI of diff.","P Value Summary","Adjusted P Value","Cohen's d","Hedges' g"]
["Control",4.3,"-0.06505 to 8.665","ns",0.0534,{"v":1.49374618382394,"d":"1.49"},{"v":1.99166157843192,"d":"1.99"}]
["QX314",17,"12.63 to 21.37","****","<0.0001",{"v":5.90550816860628,"d":"5.91"},{"v":7.87401089147504,"d":"7.87"}]
[]
[]
[]
[]
["Figure 3j"]
["Comparison (pre - after)","Mean Diff.","95.00% CI of diff.","P Value Summary","Adjusted P Value","Cohen's d","Hedges' g"]
["Control",0.3333,"-6.917 to 7.584","ns",0.9912,{"v":0.0696960683523731,"d":"0.07"},{"v":0.0929280911364975,"d":"0.09"}]
["QX314",20.9,"13.65 to 28.15","****","<0.0001",{"v":4.37038052374617,"d":"4.37"},{"v":5.82717403166156,"d":"5.83"}]
[]
[]
[]
[]
["Figure 3k"]
["Comparison (pre - after)","Mean Diff.","95.00% CI of diff.","P Value Summary","Adjusted P Value","Cohen's d","Hedges' g"]
["Control",-0.1667,"-0.8230 to 0.4896","ns",0.7695,{"v":-0.385131211980435,"d":"-0.39"},{"v":-0.513508282640579,"d":"-0.51"}]
["QX314",1.367,"0.7104 to 2.023","***",0.0005,{"v":3.15821455775197,"d":"3.16"},{"v":4.2109527436693,"d":"4.21"}]
[]
[]
[]
[]
["Figure 3l"]
["Comparison (pre - after)","Mean Diff.","95.00% CI of diff.","P Value Summary","Adjusted P Value","Cohen's d","Hedges' g"]
["Control",0.1,"-0.6058 to 0.8058","ns",0.9202,{"v":0.214867982578945,"d":"0.21"},{"v":0.286490643438594,"d":"0.29"}]
["QX314",1.033,"0.3275 to 1.739","**",0.0065,{"v":2.2195862600405,"d":"2.22"},{"v":2.95944834672067,"d":"2.96"}]

{"sheet":"Figure 4","index":3,"n_rows":25,"n_cols":7,"rows_kept":25,"merged":[[1,0,1,6],[8,0,8,6],[15,0,15,6],[22,0,22,6]],"flags":["formulas_cached_only"]}
[]
["Figure 4j"]
["Comparison","Difference between means ± SEM","95.00% CI of diff.","P Value Summary","Adjusted P Value","Cohen's d","Hedges' g"]
["AAV-MBP-Cre-eGFP+AAV-CMV-Dio-taCasp3 vs. AAV-MBP-Cre-eGFP","-4.713 ± 0.7021","-6.662 to -2.764","**",0.0026,5.48,4.38]
[]
[]
[]
[]
["Figure 4k"]
["Comparison","Difference between means ± SEM","95.00% CI of diff.","P Value Summary","Adjusted P Value","Cohen's d","Hedges' g"]
["AAV-MBP-Cre-eGFP+AAV-CMV-Dio-taCasp3 vs. AAV-MBP-Cre-eGFP","-81.85 ± 9.954","-109.5 to -54.22","**",0.0012,6.72,5.38]
[]
[]
[]
[]
["Figure 4m"]
["Comparison","Difference between means ± SEM","95.00% CI of diff.","P Value Summary","Adjusted P Value","Cohen's d","Hedges' g"]
["AAV-MBP-Cre-eGFP+AAV-CMV-Dio-taCasp3 vs. AAV-MBP-Cre-eGFP","-39.44 ± 10.06","-62.64 to -16.23","**",0.0044,2.48,2.24]
[]
[]
[]
[]
["Figure 4n"]
["Comparison","Difference between means ± SEM","95.00% CI of diff.","P Value Summary","Adjusted P Value","Cohen's d","Hedges' g"]
["AAV-MBP-Cre-eGFP+AAV-CMV-Dio-taCasp3 vs. AAV-MBP-Cre-eGFP","-18.93 ± 3.841","-27.79 to -10.07","**",0.0012,3.12,2.82]

{"sheet":"Figure 5","index":4,"n_rows":93,"n_cols":7,"rows_kept":93,"merged":[[1,0,1,6],[13,0,13,6],[25,0,25,6],[37,0,37,6],[49,0,49,6],[61,0,61,6],[73,0,73,6],[85,0,85,6]],"flags":["formulas_cached_only"]}
[]
["Figure 5c-0.5psi"]
["Comparison","Mean Diff.","95.00% CI of diff.","P Value Summary","Adjusted P Value","Cohen's d","Hedges' g"]
["MBP-cre+Caspase3 vs. MBP-cre",26.29,"19.92 to 32.65","****","<0.0001",{"v":6.38428884877585,"d":"6.38"},{"v":8.51238513170113,"d":"8.51"}]
["MBP-cre+Caspase3 vs. hSyn-cre+Caspase3",28.74,"22.63 to 34.85","****","<0.0001",{"v":6.97963479560479,"d":"6.98"},{"v":9.30617972747306,"d":"9.31"}]
["MBP-cre+Caspase3 vs. hSyn-cre",26.02,"19.66 to 32.38","****","<0.0001",{"v":6.31872178946929,"d":"6.32"},{"v":8.42496238595905,"d":"8.42"}]
["MBP-cre vs. hSyn-cre+Caspase3",2.457,"-3.904 to 8.818","ns",0.7093,{"v":0.596660239689702,"d":"0.60"},{"v":0.795546986252936,"d":"0.80"}]
["MBP-cre vs. hSyn-cre",-0.2667,"-6.868 to 6.334","ns",0.9995,{"v":-0.0647788459372626,"d":"-0.06"},{"v":-0.0863717945830168,"d":"-0.09"}]
["hSyn-cre+Caspase3 vs. hSyn-cre",-2.724,"-9.085 to 3.637","ns",0.6399,{"v":-0.661498776115079,"d":"-0.66"},{"v":-0.881998368153438,"d":"-0.88"}]
[]
[]
[]
[]
["Figure 5c-1.0psi"]
["Comparison","Mean Diff.","95.00% CI of diff.","P Value Summary","Adjusted P Value","Cohen's d","Hedges' g"]
["MBP-cre+Caspase3 vs. MBP-cre",19.62,"11.28 to 27.96","****","<0.0001",{"v":3.63367520705171,"d":"3.63"},{"v":4.84490027606895,"d":"4.84"}]
["MBP-cre+Caspase3 vs. hSyn-cre+Caspase3",19.57,"11.56 to 27.59","****","<0.0001",{"v":3.62334776877461,"d":"3.62"},{"v":4.83113035836614,"d":"4.83"}]
["MBP-cre+Caspase3 vs. hSyn-cre",19.82,"11.48 to 28.16","****","<0.0001",{"v":3.67071572904001,"d":"3.67"},{"v":4.89428763872001,"d":"4.89"}]
["MBP-cre vs. hSyn-cre+Caspase3",-0.04762,"-8.391 to 8.295","ns",">0.9999",{"v":-0.00881934828541298,"d":"-0.01"},{"v":-0.0117591310472173,"d":"-0.01"}]
["MBP-cre vs. hSyn-cre",0.2,"-8.458 to 8.858","ns",">0.9999",{"v":0.0370333719813743,"d":"0.04"},{"v":0.0493778293084991,"d":"0.05"}]
["hSyn-cre+Caspase3 vs. hSyn-cre",0.2476,"-8.095 to 8.591","ns",0.9998,{"v":0.0458561662215089,"d":"0.05"},{"v":0.0611415549620118,"d":"0.06"}]
[]
[]
[]
[]
["Figure 5c-1.5psi"]
["Comparison","Mean Diff.","95.00% CI of diff.","P Value Summary","Adjusted P Value","Cohen's d","Hedges' g"]
["MBP-cre+Caspase3 vs. MBP-cre",22.28,"15.10 to 29.46","****","<0.0001",{"v":4.79699988586923,"d":"4.80"},{"v":6.39599984782564,"d":"6.40"}]
["MBP-cre+Caspase3 vs. hSyn-cre+Caspase3",22.74,"15.85 to 29.64","****","<0.0001",{"v":4.89530458404231,"d":"4.90"},{"v":6.52707277872308,"d":"6.53"}]
["MBP-cre+Caspase3 vs. hSyn-cre",21.55,"14.37 to 28.72","****","<0.0001",{"v":4.63982708889057,"d":"4.64"},{"v":6.18643611852076,"d":"6.19"}]
["MBP-cre vs. hSyn-cre+Caspase3",0.4619,"-6.715 to 7.638","ns",0.9979,{"v":0.0994494724992368,"d":"0.10"},{"v":0.132599296665649,"d":"0.13"}]
["MBP-cre vs. hSyn-cre",-0.7333,"-8.181 to 6.714","ns",0.9926,{"v":-0.157856432660982,"d":"-0.16"},{"v":-0.210475243547975,"d":"-0.21"}]
["hSyn-cre+Caspase3 vs. hSyn-cre",-1.195,"-8.372 to 5.981","ns",0.9664,{"v":-0.257289715602052,"d":"-0.26"},{"v":-0.34305295413607,"d":"-0.34"}]
[]
[]
[]
[]
["Figure 5c-2.0psi"]
["Comparison","Mean Diff.","95.00% CI of diff.","P Value Summary","Adjusted P Value","Cohen's d","Hedges' g"]
["MBP-cre+Caspase3 vs. MBP-cre",24.8,"16.83 to 32.77","****","<0.0001",{"v":4.80412474879939,"d":"4.80"},{"v":6.40549966506585,"d":"6.41"}]
["MBP-cre+Caspase3 vs. hSyn-cre+Caspase3",28.09,"20.42 to 35.75","****","<0.0001",{"v":5.44209371897064,"d":"5.44"},{"v":7.25612495862752,"d":"7.26"}]
["MBP-cre+Caspase3 vs. hSyn-cre",26.37,"18.39 to 34.34","****","<0.0001",{"v":5.1082568397516,"d":"5.11"},{"v":6.8110091196688,"d":"6.81"}]
["MBP-cre vs. hSyn-cre+Caspase3",3.286,"-4.688 to 11.26","ns",0.6669,{"v":0.636546529215918,"d":"0.64"},{"v":0.848728705621225,"d":"0.85"}]
["MBP-cre vs. hSyn-cre",1.567,"-6.708 to 9.842","ns",0.9519,{"v":0.303593245577229,"d":"0.30"},{"v":0.404790994102972,"d":"0.40"}]
["hSyn-cre+Caspase3 vs. hSyn-cre",-1.719,"-9.693 to 6.255","ns",0.9314,{"v":-0.332995582386538,"d":"-0.33"},{"v":-0.443994109848717,"d":"-0.44"}]
[]
[]
[]
[]
["Figure 5d-0.5psi"]
["Comparison","Mean Diff.","95.00% CI of diff.","P Value Summary","Adjusted P Value","Cohen's d","Hedges' g"]
["MBP-cre+Caspase3 vs. MBP-cre",2.105,"0.8436 to 3.366","***",0.0007,{"v":2.57841014477348,"d":"2.58"},{"v":3.4378801930313,"d":"3.44"}]
["MBP-cre+Caspase3 vs. hSyn-cre+Caspase3",1.8,"0.5883 to 3.012","**",0.0023,{"v":2.20472151898425,"d":"2.20"},{"v":2.939628691979,"d":"2.94"}]
["MBP-cre+Caspase3 vs. hSyn-cre",1.471,"0.2102 to 2.733","*",0.0183,{"v":1.80182485651391,"d":"1.80"},{"v":2.40243314201855,"d":"2.40"}]
["MBP-cre vs. hSyn-cre+Caspase3",-0.3048,"-1.566 to 0.9564","ns",0.9069,{"v":-0.373348889371475,"d":"-0.37"},{"v":-0.497798519161967,"d":"-0.50"}]
["MBP-cre vs. hSyn-cre",-0.6333,"-1.942 to 0.6755","ns",0.5462,{"v":-0.775802939694016,"d":"-0.78"},{"v":-1.03440391959202,"d":"-1.03"}]
["hSyn-cre+Caspase3 vs. hSyn-cre",-0.3286,"-1.590 to 0.9326","ns",0.8867,{"v":-0.402501460129484,"d":"-0.40"},{"v":-0.536668613505979,"d":"-0.54"}]
[]
[]
[]
[]
["Figure 5d-1.0psi"]
["Comparison","Mean Diff.","95.00% CI of diff.","P Value Summary","Adjusted P Value","Cohen's d","Hedges' g"]
["MBP-cre+Caspase3 vs. MBP-cre",2.371,"1.372 to 3.371","****","<0.0001",{"v":3.66621074504277,"d":"3.67"},{"v":4.88828099339035,"d":"4.89"}]
["MBP-cre+Caspase3 vs. hSyn-cre+Caspase3",2.057,"1.097 to 3.017","****","<0.0001",{"v":3.18054020603909,"d":"3.18"},{"v":4.24072027471879,"d":"4.24"}]
["MBP-cre+Caspase3 vs. hSyn-cre",2.071,"1.072 to 3.071","****","<0.0001",{"v":3.20232916616768,"d":"3.20"},{"v":4.26977222155691,"d":"4.27"}]
["MBP-cre vs. hSyn-cre+Caspase3",-0.3143,"-1.313 to 0.6849","ns",0.8184,{"v":-0.485993267468132,"d":"-0.49"},{"v":-0.647991023290843,"d":"-0.65"}]
["MBP-cre vs. hSyn-cre",-0.3,"-1.337 to 0.7369","ns",0.8521,{"v":-0.463859348572276,"d":"-0.46"},{"v":-0.618479131429701,"d":"-0.62"}]
["hSyn-cre+Caspase3 vs. hSyn-cre",0.01429,"-0.9849 to 1.013","ns",">0.9999",{"v":0.0220962258737499,"d":"0.02"},{"v":0.0294616344983333,"d":"0.03"}]
[]
[]
[]
[]
["Figure 5d-1.5psi"]
["Comparison","Mean Diff.","95.00% CI of diff.","P Value Summary","Adjusted P Value","Cohen's d","Hedges' g"]
["MBP-cre+Caspase3 vs. MBP-cre",2.286,"1.008 to 3.564","***",0.0003,{"v":2.76300888908088,"d":"2.76"},{"v":3.68401185210785,"d":"3.68"}]
["MBP-cre+Caspase3 vs. hSyn-cre+Caspase3",2.143,"0.9148 to 3.371","***",0.0004,{"v":2.59041538407203,"d":"2.59"},{"v":3.4538871787627,"d":"3.45"}]
["MBP-cre+Caspase3 vs. hSyn-cre",1.552,"0.2742 to 2.831","*",0.0135,{"v":1.87584855461659,"d":"1.88"},{"v":2.50113140615546,"d":"2.50"}]
["MBP-cre vs. hSyn-cre+Caspase3",-0.1429,"-1.421 to 1.135","ns",0.9893,{"v":-0.172718272200201,"d":"-0.17"},{"v":-0.230291029600267,"d":"-0.23"}]
["MBP-cre vs. hSyn-cre",-0.7333,"-2.060 to 0.5931","ns",0.4345,{"v":-0.886269525636911,"d":"-0.89"},{"v":-1.18169270084922,"d":"-1.18"}]
["hSyn-cre+Caspase3 vs. hSyn-cre",-0.5905,"-1.869 to 0.6877","ns",0.583,{"v":-0.713716863080605,"d":"-0.71"},{"v":-0.951622484107473,"d":"-0.95"}]
[]
[]
[]
[]
["Figure 5d-2.0psi"]
["Comparison","Mean Diff.","95.00% CI of diff.","P Value Summary","Adjusted P Value","Cohen's d","Hedges' g"]
["MBP-cre+Caspase3 vs. MBP-cre",2.367,"0.7827 to 3.951","**",0.0022,{"v":2.30869079857176,"d":"2.31"},{"v":3.07825439809568,"d":"3.08"}]
["MBP-cre+Caspase3 vs. hSyn-cre+Caspase3",3.2,"1.678 to 4.722","****","<0.0001",{"v":3.12129917561955,"d":"3.12"},{"v":4.16173223415941,"d":"4.16"}]
["MBP-cre+Caspase3 vs. hSyn-cre",2.067,"0.4827 to 3.651","**",0.0076,{"v":2.01608106491247,"d":"2.02"},{"v":2.68810808654996,"d":"2.69"}]
["MBP-cre vs. hSyn-cre+Caspase3",0.8333,"-0.7506 to 2.417","ns",0.4768,{"v":0.812772303527607,"d":"0.81"},{"v":1.08369640470348,"d":"1.08"}]
["MBP-cre vs. hSyn-cre",-0.3,"-1.944 to 1.344","ns",0.9566,{"v":-0.292625579923784,"d":"-0.29"},{"v":-0.390167439898379,"d":"-0.39"}]
["hSyn-cre+Caspase3 vs. hSyn-cre",-1.133,"-2.717 to 0.4506","ns",0.2231,{"v":-1.10508942745323,"d":"-1.11"},{"v":-1.47345256993764,"d":"-1.47"}]

{"sheet":"Figure 6","index":5,"n_rows":133,"n_cols":7,"rows_kept":133,"merged":[[1,0,1,6],[10,0,10,6],[19,0,19,6],[28,0,28,6],[37,0,37,6],[46,0,46,6],[55,0,55,6],[64,0,64,6],[73,0,73,6],[81,0,81,6],[89,0,89,6],[97,0,97,6],[105,0,105,6],[113,0,113,6],[121,0,121,6],[129,0,129,6]],"flags":["formulas_cached_only"]}
[]
["Figure 6a-0.5psi"]
["Comparison (pre - after)","Mean Diff.","95.00% CI of diff.","P Value Summary","Adjusted P Value","Cohen's d","Hedges' g"]
["Vehicle",-3.167,"-12.88 to 6.544","ns",0.7786,{"v":-0.505660481892573,"d":"-0.51"},{"v":-0.674213975856764,"d":"-0.67"}]
["Carbamazepine",17.33,"7.622 to 27.04","***",0.0007,{"v":2.76700225803546,"d":"2.77"},{"v":3.68933634404728,"d":"3.69"}]
["Pregabalin",6.033,"-3.678 to 15.74","ns",0.3092,{"v":0.963261663169528,"d":"0.96"},{"v":1.28434888422604,"d":"1.28"}]
[]
[]
[]
[]
["Figure 6a-1.0psi"]
["Comparison (pre - after)","Mean Diff.","95.00% CI of diff.","P Value Summary","Adjusted P Value","Cohen's d","Hedges' g"]
["Vehicle",0.8667,"-11.71 to 13.45","ns",0.997,{"v":0.106806718955528,"d":"0.11"},{"v":0.142408958607371,"d":"0.14"}]
["Carbamazepine",23.71,"11.13 to 36.29","***",0.0004,{"v":2.92187297384974,"d":"2.92"},{"v":3.89583063179965,"d":"3.90"}]
["Pregabalin",1.733,"-10.85 to 14.31","ns",0.9772,{"v":0.213564144398212,"d":"0.21"},{"v":0.284752192530949,"d":"0.28"}]
[]
[]
[]
[]
["Figure 6a-1.5psi"]
["Comparison (pre - after)","Mean Diff.","95.00% CI of diff.","P Value Summary","Adjusted P Value","Cohen's d","Hedges' g"]
["Vehicle",-0.9,"-10.55 to 8.755","ns",0.9927,{"v":-0.144538314957069,"d":"-0.14"},{"v":-0.192717753276092,"d":"-0.19"}]
["Carbamazepine",31.57,"21.91 to 41.22","****","<0.0001",{"v":5.07008289243852,"d":"5.07"},{"v":6.76011052325136,"d":"6.76"}]
["Pregabalin",-0.7,"-10.35 to 8.955","ns",0.9965,{"v":-0.112418689411054,"d":"-0.11"},{"v":-0.149891585881405,"d":"-0.15"}]
[]
[]
[]
[]
["Figure 6a-2.0psi"]
["Comparison (pre - after)","Mean Diff.","95.00% CI of diff.","P Value Summary","Adjusted P Value","Cohen's d","Hedges' g"]
["Vehicle",1.733,"-9.900 to 13.37","ns",0.9715,{"v":0.230966762812932,"d":"0.23"},{"v":0.307955683750576,"d":"0.31"}]
["Carbamazepine",26.57,"14.93 to 38.20","****","<0.0001",{"v":3.54113496130387,"d":"3.54"},{"v":4.72151328173849,"d":"4.72"}]
["Pregabalin",8.067,"-3.566 to 19.70","ns",0.2272,{"v":1.07513495419038,"d":"1.08"},{"v":1.43351327225384,"d":"1.43"}]
[]
[]
[]
[]
["Figure 6b-0.5psi"]
["Comparison (pre - after)","Mean Diff.","95.00% CI of diff.","P Value Summary","Adjusted P Value","Cohen's d","Hedges' g"]
["Vehicle",-0.7,"-1.622 to 0.2218","ns",0.168,{"v":-1.17723620283349,"d":"-1.18"},{"v":-1.56964827044466,"d":"-1.57"}]
["Carbamazepine",0.9667,"0.04483 to 1.889","*",0.0386,{"v":1.62576319611305,"d":"1.63"},{"v":2.16768426148407,"d":"2.17"}]
["Pregabalin",0.6333,"-0.2885 to 1.555","ns",0.2337,{"v":1.0650624103635,"d":"1.07"},{"v":1.420083213818,"d":"1.42"}]
[]
[]
[]
[]
["Figure 6b-1.0psi"]
["Comparison (pre - after)","Mean Diff.","95.00% CI of diff.","P Value Summary","Adjusted P Value","Cohen's d","Hedges' g"]
["Vehicle",-0.3,"-1.537 to 0.9372","ns",0.8927,{"v":-0.375879081503663,"d":"-0.38"},{"v":-0.50117210867155,"d":"-0.50"}]
["Carbamazepine",1.767,"0.5294 to 3.004","**",0.0049,{"v":2.21392779005657,"d":"2.21"},{"v":2.95190372007543,"d":"2.95"}]
["Pregabalin",0.8667,"-0.3706 to 2.104","ns",0.2201,{"v":1.08591466646408,"d":"1.09"},{"v":1.44788622195211,"d":"1.45"}]
[]
[]
[]
[]
["Figure 6b-1.5psi"]
["Comparison (pre - after)","Mean Diff.","95.00% CI of diff.","P Value Summary","Adjusted P Value","Cohen's d","Hedges' g"]
["Vehicle",0.5667,"-0.2481 to 1.381","ns",0.2251,{"v":1.07839287260963,"d":"1.08"},{"v":1.4378571634795,"d":"1.44"}]
["Carbamazepine",1.233,"0.4185 to 2.048","**",0.003,{"v":2.34631800234281,"d":"2.35"},{"v":3.12842400312375,"d":"3.13"}]
["Pregabalin",0.9,"0.08519 to 1.715","*",0.0286,{"v":1.71264087762249,"d":"1.71"},{"v":2.28352117016332,"d":"2.28"}]
[]
[]
[]
[]
["Figure 6b-2.0psi"]
["Comparison (pre - after)","Mean Diff.","95.00% CI of diff.","P Value Summary","Adjusted P Value","Cohen's d","Hedges' g"]
["Vehicle",0.03333,"-1.542 to 1.609","ns",">0.9999",{"v":0.0328044399456022,"d":"0.03"},{"v":0.0437392532608029,"d":"0.04"}]
["Carbamazepine",1.4,"-0.1753 to 2.975","ns",0.0891,{"v":1.3779242701423,"d":"1.38"},{"v":1.83723236018974,"d":"1.84"}]
["Pregabalin",1.1,"-0.4753 to 2.675","ns",0.2223,{"v":1.08265478368324,"d":"1.08"},{"v":1.44353971157765,"d":"1.44"}]
[]
[]
[]
[]
["Figure 6c-0.5psi"]
["Comparison (pre - after)","Mean Diff.","95.00% CI of diff.","P Value Summary","Adjusted P Value","Cohen's d","Hedges' g"]
["Control",-6.6,"-15.65 to 2.452","ns",0.167,{"v":-1.0748975392529,"d":"-1.07"},{"v":-1.43319671900387,"d":"-1.43"}]
["QX314",20.9,"13.06 to 28.74","****","<0.0001",{"v":3.40390879478827,"d":"3.40"},{"v":4.5385450597177,"d":"4.54"}]
[]
[]
[]
[]
["Figure 6c-1.0psi"]
["Comparison (pre - after)","Mean Diff.","95.00% CI of diff.","P Value Summary","Adjusted P Value","Cohen's d","Hedges' g"]
["Control",-5.067,"-18.66 to 8.525","ns",0.5904,{"v":-0.549583658460235,"d":"-0.55"},{"v":-0.732778211280314,"d":"-0.73"}]
["QX314",29.35,"17.58 to 41.12","****","<0.0001",{"v":3.18329718004338,"d":"3.18"},{"v":4.24439624005784,"d":"4.24"}]
[]
[]
[]
[]
["Figure 6c-1.5psi"]
["Comparison (pre - after)","Mean Diff.","95.00% CI of diff.","P Value Summary","Adjusted P Value","Cohen's d","Hedges' g"]
["Control",-3.9,"-12.86 to 5.060","ns",0.4934,{"v":-0.641500299099584,"d":"-0.64"},{"v":-0.855333732132779,"d":"-0.86"}]
["QX314",32.63,"24.87 to 40.38","****","<0.0001",{"v":5.36854228364594,"d":"5.37"},{"v":7.15805637819458,"d":"7.16"}]
[]
[]
[]
[]
["Figure 6c-2.0psi"]
["Comparison (pre - after)","Mean Diff.","95.00% CI of diff.","P Value Summary","Adjusted P Value","Cohen's d","Hedges' g"]
["Control",1.6,"-6.663 to 9.863","ns",0.8631,{"v":0.285375480600371,"d":"0.29"},{"v":0.380500640800495,"d":"0.38"}]
["QX314",47.6,"40.44 to 54.76","****","<0.0001",{"v":8.49090260435248,"d":"8.49"},{"v":11.32120347247,"d":"11.32"}]
[]
[]
[]
[]
["Figure 6d-0.5psi"]
["Comparison (pre - after)","Mean Diff.","95.00% CI of diff.","P Value Summary","Adjusted P Value","Cohen's d","Hedges' g"]
["Control",-0.3,"-0.9630 to 0.3630","ns",0.4678,{"v":-0.666942937069263,"d":"-0.67"},{"v":-0.889257249425685,"d":"-0.89"}]
["QX314",1.925,"1.351 to 2.499","****","<0.0001",{"v":4.27967985771454,"d":"4.28"},{"v":5.70623981028605,"d":"5.71"}]
[]
[]
[]
[]
["Figure 6d-1.0psi"]
["Comparison (pre - after)","Mean Diff.","95.00% CI of diff.","P Value Summary","Adjusted P Value","Cohen's d","Hedges' g"]
["Control",-0.4333,"-1.373 to 0.5061","ns",0.455,{"v":-0.679798564238763,"d":"-0.68"},{"v":-0.906398085651684,"d":"-0.91"}]
["QX314",2.425,"1.611 to 3.239","****","<0.0001",{"v":3.80451835582052,"d":"3.80"},{"v":5.07269114109403,"d":"5.07"}]
[]
[]
[]
[]
["Figure 6d-1.5psi"]
["Comparison (pre - after)","Mean Diff.","95.00% CI of diff.","P Value Summary","Adjusted P Value","Cohen's d","Hedges' g"]
["Control",0.3667,"-0.8706 to 1.604","ns",0.7126,{"v":0.436884737333545,"d":"0.44"},{"v":0.582512983111393,"d":"0.58"}]
["QX314",3.125,"2.054 to 4.196","****","<0.0001",{"v":3.72289730760067,"d":"3.72"},{"v":4.96386307680089,"d":"4.96"}]
[]
[]
[]
[]
["Figure 6d-2.0psi"]
["Comparison (pre - after)","Mean Diff.","95.00% CI of diff.","P Value Summary","Adjusted P Value","Cohen's d","Hedges' g"]
["Control",0.3333,"-0.9854 to 1.652","ns",0.7799,{"v":0.372566979130498,"d":"0.37"},{"v":0.496755972173997,"d":"0.50"}]
["QX314",2.425,"1.283 to 3.567","***",0.0003,{"v":2.71070869662419,"d":"2.71"},{"v":3.61427826216559,"d":"3.61"}]

{"sheet":"Figure 7","index":6,"n_rows":27,"n_cols":7,"rows_kept":27,"merged":[[1,0,1,6],[12,0,12,6],[23,0,23,6]],"flags":["formulas_cached_only"]}
[]
["Figure 7e"]
["Comparison (LPC vs. PBS)","Mean Diff.","95.00% CI of diff.","P Value Summary","Adjusted P Value","Cohen's d","Hedges' g"]
["1.25psi",16.7,"12.05 to 21.35","***",0.0001,{"v":8.24081153458697,"d":"8.24"},{"v":10.9877487127826,"d":"10.99"}]
["2.50psi",19.98,"11.38 to 28.59","**",0.0012,{"v":5.35536600668929,"d":"5.36"},{"v":7.14048800891905,"d":"7.14"}]
["3.75psi",18.08,"13.63 to 22.54","****","<0.0001",{"v":9.32008291691824,"d":"9.32"},{"v":12.4267772225577,"d":"12.43"}]
["5.00psi",21.9,"13.60 to 30.20","***",0.0006,{"v":6.09347994951942,"d":"6.09"},{"v":8.12463993269256,"d":"8.12"}]
["6.25psi",15.83,"7.778 to 23.89","**",0.0026,{"v":4.52896668051129,"d":"4.53"},{"v":6.03862224068171,"d":"6.04"}]
[]
[]
[]
[]
["Figure 7f"]
["Comparison (LPC vs. PBS)","Mean Diff.","95.00% CI of diff.","P Value Summary","Adjusted P Value","Cohen's d","Hedges' g"]
["1.25psi",2.333,"0.5594 to 4.107","*",0.015,{"v":2.90417890905433,"d":"2.90"},{"v":3.87223854540577,"d":"3.87"}]
["2.50psi",3.433,"1.480 to 5.386","**",0.0028,{"v":3.65286301903425,"d":"3.65"},{"v":4.870484025379,"d":"4.87"}]
["3.75psi",3.4,"1.761 to 5.039","**",0.001,{"v":4.25442331002325,"d":"4.25"},{"v":5.67256441336433,"d":"5.67"}]
["5.00psi",3.367,"1.619 to 5.114","**",0.0017,{"v":4.00316794967354,"d":"4.00"},{"v":5.33755726623138,"d":"5.34"}]
["6.25psi",3.7,"1.872 to 5.528","**",0.001,{"v":4.07437725729852,"d":"4.07"},{"v":5.43250300973136,"d":"5.43"}]
[]
[]
[]
[]
["Figure 7f-5.0psi"]
["Comparison (pre - after)","Mean Diff.","95.00% CI of diff.","P Value Summary","Adjusted P Value","Cohen's d","Hedges' g"]
["Vehicle",0,"-0.6289 to 0.6289","ns",">0.9999",{"v":0,"d":"0.00"},{"v":0,"d":"0.00"}]
["Carbamazepine",2.8,"2.171 to 3.429","****","<0.0001",{"v":6.75263472736404,"d":"6.75"},{"v":9.00351296981872,"d":"9.00"}]

{"sheet":"Figure S11","index":7,"n_rows":21,"n_cols":7,"rows_kept":21,"merged":[[1,0,1,6],[13,0,13,6]],"flags":["formulas_cached_only"]}
[]
["Figure S11b"]
["Comparison (LPC vs. PBS)","Mean Diff.","95.00% CI of diff.","P Value Summary","Adjusted P Value","Cohen's d","Hedges' g"]
["0.008g/1.25",17.54,"9.757 to 25.32","****","<0.0001",{"v":2.2595422142405748,"d":"2.26"},{"v":3.0127229523207664,"d":"3.01"}]
["0.02g/2.36",18.04,"10.27 to 25.82","****","<0.0001",{"v":2.3239533377936126,"d":"2.32"},{"v":3.098604450391483,"d":"3.10"}]
["0.04g/2.44",13.28,"5.499 to 21.06","**",0.0011,{"v":1.7107594415686904,"d":"1.71"},{"v":2.2810125887582537,"d":"2.28"}]
["0.07g/2.83",14.34,"6.559 to 22.12","***",0.0004,{"v":1.8473110235011312,"d":"1.85"},{"v":2.4630813646681746,"d":"2.46"}]
["0.16g/3.22",15.59,"7.815 to 23.37","***",0.0001,{"v":2.008338832383726,"d":"2.01"},{"v":2.677785109844968,"d":"2.68"}]
["0.4g/3.61",19.76,"11.98 to 27.54","****","<0.0001",{"v":2.545527602816064,"d":"2.55"},{"v":3.394036803754752,"d":"3.39"}]
[]
[]
[]
[]
["Figure S11c"]
["Comparison (LPC vs. PBS)","Mean Diff.","95.00% CI of diff.","P Value Summary","Adjusted P Value","Cohen's d","Hedges' g"]
["0.008g/1.25",0.001587,"-0.2329 to 0.2360","ns",0.9884,{"v":0.007467533378968487,"d":"0.01"},{"v":0.009956711171957983,"d":"0.01"}]
["0.02g/2.36",0.2429,"-0.1479 to 0.6336","ns",0.2037,{"v":0.6722135858974285,"d":"0.67"},{"v":0.8962847811965713,"d":"0.90"}]
["0.04g/2.44",0.05556,"-0.1794 to 0.2905","ns",0.6129,{"v":0.26241432202927417,"d":"0.26"},{"v":0.3498857627056989,"d":"0.35"}]
["0.07g/2.83",0.2857,"-0.01655 to 0.5880","ns",0.0619,{"v":1.033591289195848,"d":"1.03"},{"v":1.3781217189277974,"d":"1.38"}]
["0.16g/3.22",0.1698,"-0.1980 to 0.5376","ns",0.3378,{"v":0.5007089332316504,"d":"0.50"},{"v":0.6676119109755339,"d":"0.67"}]
["0.4g/3.61",0.3984,"0.07259 to 0.7242","*",0.0203,{"v":1.3313974009449703,"d":"1.33"},{"v":1.7751965345932936,"d":"1.78"}]

{"sheet":"Figure S12","index":8,"n_rows":51,"n_cols":7,"rows_kept":51,"merged":[[1,0,1,6],[10,0,10,6],[19,0,19,6],[28,0,28,6],[37,0,37,6],[46,0,46,6]],"flags":["formulas_cached_only"]}
[]
["Figure S12a-1.25psi"]
["Comparison (pre - after)","Mean Diff.","95.00% CI of diff.","P Value Summary","Adjusted P Value","Cohen's d","Hedges' g"]
["Vehicle",1.617,"-6.527 to 9.761","ns",0.9379,{"v":0.3054893276438563,"d":"0.31"},{"v":0.40731910352514167,"d":"0.41"}]
["Carbamazepine",14.84,"7.303 to 22.38","***",0.0002,{"v":2.802937689032069,"d":"2.80"},{"v":3.7372502520427586,"d":"3.74"}]
["Pregabalin",5.6,"-2.544 to 13.74","ns",0.2354,{"v":1.0579716974679003,"d":"1.06"},{"v":1.4106289299572004,"d":"1.41"}]
[]
[]
[]
[]
["Figure S12a-3.75psi"]
["Comparison (pre - after)","Mean Diff.","95.00% CI of diff.","P Value Summary","Adjusted P Value","Cohen's d","Hedges' g"]
["Vehicle",2.733,"-4.296 to 9.763","ns",0.6794,{"v":0.5981418823712082,"d":"0.60"},{"v":0.7975225098282777,"d":"0.80"}]
["Carbamazepine",16.93,"10.42 to 23.44","****","<0.0001",{"v":3.705759889907735,"d":"3.71"},{"v":4.941013186543646,"d":"4.94"}]
["Pregabalin",10.07,"3.037 to 17.10","**",0.0046,{"v":2.2039109972477378,"d":"2.20"},{"v":2.9385479963303167,"d":"2.94"}]
[]
[]
[]
[]
["Figure S12a-6.25psi"]
["Comparison (pre - after)","Mean Diff.","95.00% CI of diff.","P Value Summary","Adjusted P Value","Cohen's d","Hedges' g"]
["Vehicle",-1.05,"-11.15 to 9.051","ns",0.9901,{"v":-0.15990972900266606,"d":"-0.16"},{"v":-0.21321297200355474,"d":"-0.21"}]
["Carbamazepine",16.06,"6.705 to 25.41","***",0.0009,{"v":2.445706863312556,"d":"2.45"},{"v":3.2609424844167414,"d":"3.26"}]
["Pregabalin",6.367,"-3.734 to 16.47","ns",0.3009,{"v":0.9696621376761665,"d":"0.97"},{"v":1.2928828502348886,"d":"1.29"}]
[]
[]
[]
[]
["Figure S12b-1.25psi"]
["Comparison (pre - after)","Mean Diff.","95.00% CI of diff.","P Value Summary","Adjusted P Value","Cohen's d","Hedges' g"]
["Vehicle",-0.1,"-0.5059 to 0.3059","ns",0.89,{"v":-0.3790875043924004,"d":"-0.38"},{"v":-0.5054500058565339,"d":"-0.51"}]
["Carbamazepine",0.7714,"0.3956 to 1.147","***",0.0002,{"v":2.9243308086701303,"d":"2.92"},{"v":3.8991077448935068,"d":"3.90"}]
["Pregabalin",0.1333,"-0.2726 to 0.5392","ns",0.7779,{"v":0.5053236433550697,"d":"0.51"},{"v":0.6737648578067597,"d":"0.67"}]
[]
[]
[]
[]
["Figure S12b-3.75psi"]
["Comparison (pre - after)","Mean Diff.","95.00% CI of diff.","P Value Summary","Adjusted P Value","Cohen's d","Hedges' g"]
["Vehicle",-0.3333,"-1.927 to 1.260","ns",0.9285,{"v":-0.3217907102356225,"d":"-0.32"},{"v":-0.4290542803141633,"d":"-0.43"}]
["Carbamazepine",1.686,"0.2103 to 3.161","*",0.023,{"v":1.6276050347276414,"d":"1.63"},{"v":2.170140046303522,"d":"2.17"}]
["Pregabalin",0.8667,"-0.7270 to 2.460","ns",0.4212,{"v":0.8367717028539274,"d":"0.84"},{"v":1.1156956038052366,"d":"1.12"}]
[]
[]
[]
[]
["Figure S12b-6.25psi"]
["Comparison (pre - after)","Mean Diff.","95.00% CI of diff.","P Value Summary","Adjusted P Value","Cohen's d","Hedges' g"]
["Vehicle",-0.3,"-1.802 to 1.202","ns",0.9369,{"v":-0.30726464565706535,"d":"-0.31"},{"v":-0.40968619420942043,"d":"-0.41"}]
["Carbamazepine",1.914,"0.5235 to 3.305","**",0.0062,{"v":1.960291308757924,"d":"1.96"},{"v":2.613721745010565,"d":"2.61"}]
["Pregabalin",0.5,"-1.002 to 2.002","ns",0.7711,{"v":0.5121077427617756,"d":"0.51"},{"v":0.6828103236823675,"d":"0.68"}]

{"sheet":"Figure S14","index":9,"n_rows":45,"n_cols":7,"rows_kept":45,"merged":[[1,0,1,6],[9,0,9,6],[17,0,17,6],[25,0,25,6],[33,0,33,6],[41,0,41,6]],"flags":["formulas_cached_only"]}
[]
["Figure S14a-1.25psi"]
["Comparison (pre - after)","Mean Diff.","95.00% CI of diff.","P Value Summary","Adjusted P Value","Cohen's d","Hedges' g"]
["Control",-6.833,"-16.85 to 3.186","ns",0.1963,{"v":-1.0340850299797413,"d":"-1.03"},{"v":-1.3787800399729884,"d":"-1.38"}]
["QX314",17.63,"7.614 to 27.65","**",0.0019,{"v":2.6680695270807604,"d":"2.67"},{"v":3.5574260361076804,"d":"3.56"}]
[]
[]
[]
[]
["Figure S14a-3.75psi"]
["Comparison (pre - after)","Mean Diff.","95.00% CI of diff.","P Value Summary","Adjusted P Value","Cohen's d","Hedges' g"]
["Control",-1.067,"-7.850 to 5.717","ns",0.9029,{"v":-0.23849505893353873,"d":"-0.24"},{"v":-0.31799341191138497,"d":"-0.32"}]
["QX314",20.05,"13.27 to 26.83","****","<0.0001",{"v":4.481561322977931,"d":"4.48"},{"v":5.975415097303907,"d":"5.98"}]
[]
[]
[]
[]
["Figure S14a-6.25psi"]
["Comparison (pre - after)","Mean Diff.","95.00% CI of diff.","P Value Summary","Adjusted P Value","Cohen's d","Hedges' g"]
["Control",-5.117,"-12.32 to 2.082","ns",0.1746,{"v":-1.0778187987753793,"d":"-1.08"},{"v":-1.4370917317005056,"d":"-1.44"}]
["QX314",24.53,"17.33 to 31.73","****","<0.0001",{"v":5.166874171186254,"d":"5.17"},{"v":6.889165561581671,"d":"6.89"}]
[]
[]
[]
[]
["Figure S14b-1.25psi"]
["Comparison (pre - after)","Mean Diff.","95.00% CI of diff.","P Value Summary","Adjusted P Value","Cohen's d","Hedges' g"]
["Control",-0.3333,"-1.500 to 0.8337","ns",0.7196,{"v":-0.43311016142449305,"d":"-0.43"},{"v":-0.5774802152326574,"d":"-0.58"}]
["QX314",1.567,"0.3997 to 2.734","*",0.0109,{"v":2.0362544943059726,"d":"2.04"},{"v":2.7150059924079635,"d":"2.72"}]
[]
[]
[]
[]
["Figure S14b-3.75psi"]
["Comparison (pre - after)","Mean Diff.","95.00% CI of diff.","P Value Summary","Adjusted P Value","Cohen's d","Hedges' g"]
["Control",0.06667,"-1.072 to 1.206","ns",0.9858,{"v":0.08875246125633467,"d":"0.09"},{"v":0.11833661500844622,"d":"0.12"}]
["QX314",1.233,"0.09424 to 2.372","*",0.0346,{"v":1.6413947012008498,"d":"1.64"},{"v":2.1885262682677995,"d":"2.19"}]
[]
[]
[]
[]
["Figure S14b-6.25psi"]
["Comparison (pre - after)","Mean Diff.","95.00% CI of diff.","P Value Summary","Adjusted P Value","Cohen's d","Hedges' g"]
["Control",0,"-1.193 to 1.193","ns",">0.9999",{"v":0,"d":"0.00"},{"v":0,"d":"0.00"}]
["QX314",1.267,"0.07400 to 2.459","*",0.0379,{"v":1.610884807450464,"d":"1.61"},{"v":2.147846409933952,"d":"2.15"}]

{"sheet":"Figure S16","index":10,"n_rows":11,"n_cols":7,"rows_kept":11,"merged":[[1,0,1,6],[8,0,8,6]],"flags":["formulas_cached_only"]}
[]
["Figure S16c"]
["Comparison","Mean Diff.","95.00% CI of diff.","P Value Summary","P Value","Cohen's d","Hedges' g"]
["hSyn-Cre-eGFP+CMV-Dio-taCasp3 vs. hSyn-Cre-eGFP","-0.2472 ± 0.04179","-0.3494 to -0.1449","**",0.001,4.19,3.64]
[]
[]
[]
[]
["Figure S16d"]
["Comparison","Mean Diff.","95.00% CI of diff.","P Value Summary","P Value","Cohen's d","Hedges' g"]
["hSyn-Cre-eGFP+CMV-Dio-taCasp3 vs. hSyn-Cre-eGFP","-14.00 ± 5.450","-27.34 to -0.6637","*",0.0424,1.81,1.57]

{"sheet":"Figure S17","index":11,"n_rows":141,"n_cols":7,"rows_kept":141,"merged":[[1,0,1,6],[13,0,13,6],[25,0,25,6],[37,0,37,6],[49,0,49,6],[61,0,61,6],[73,0,73,6],[85,0,85,6],[97,0,97,6],[109,0,109,6],[121,0,121,6],[133,0,133,6]],"flags":["formulas_cached_only"]}
[]
["Figure S17a-0.008g"]
["Comparison","Mean Diff.","95.00% CI of diff.","P Value Summary","Adjusted P Value","Cohen's d","Hedges' g"]
["MBP-cre+Caspase3 vs. MBP-cre",13.71,"7.071 to 20.36","****","<0.0001",{"v":3.187438302558296,"d":"3.19"},{"v":4.249917736744394,"d":"4.25"}]
["MBP-cre+Caspase3 vs. hSyn-cre+Caspase3",11.11,"4.731 to 17.50","***",0.0004,{"v":2.583099084512427,"d":"2.58"},{"v":3.444132112683236,"d":"3.44"}]
["MBP-cre+Caspase3 vs. hSyn-cre",12.31,"5.671 to 18.96","***",0.0002,{"v":2.8619522614509574,"d":"2.86"},{"v":3.8159363486012765,"d":"3.82"}]
["MBP-cre vs. hSyn-cre+Caspase3",-2.6,"-9.244 to 4.044","ns",0.7011,{"v":-0.6044740763422005,"d":"-0.60"},{"v":-0.805965435122934,"d":"-0.81"}]
["MBP-cre vs. hSyn-cre",-1.4,"-8.295 to 5.495","ns",0.9417,{"v":-0.3255297530670463,"d":"-0.33"},{"v":-0.4340396707560617,"d":"-0.43"}]
["hSyn-cre+Caspase3 vs. hSyn-cre",1.2,"-5.444 to 7.844","ns",0.9578,{"v":0.27898803523486176,"d":"0.28"},{"v":0.3719840469798157,"d":"0.37"}]
[]
[]
[]
[]
["Figure S17a-0.02g"]
["Comparison","Mean Diff.","95.00% CI of diff.","P Value Summary","Adjusted P Value","Cohen's d","Hedges' g"]
["MBP-cre+Caspase3 vs. MBP-cre",15.47,"7.150 to 23.79","***",0.0002,{"v":2.8717762645602174,"d":"2.87"},{"v":3.829035019413623,"d":"3.83"}]
["MBP-cre+Caspase3 vs. hSyn-cre+Caspase3",17.79,"9.790 to 25.78","****","<0.0001",{"v":3.302936779174734,"d":"3.30"},{"v":4.403915705566312,"d":"4.40"}]
["MBP-cre+Caspase3 vs. hSyn-cre",18.47,"10.15 to 26.79","****","<0.0001",{"v":3.4286818103702137,"d":"3.43"},{"v":4.571575747160285,"d":"4.57"}]
["MBP-cre vs. hSyn-cre+Caspase3",2.314,"-6.008 to 10.64","ns",0.8661,{"v":0.42955981100144425,"d":"0.43"},{"v":0.5727464146685923,"d":"0.57"}]
["MBP-cre vs. hSyn-cre",3,"-5.636 to 11.64","ns",0.7706,{"v":0.5569295201186101,"d":"0.56"},{"v":0.74257269349148,"d":"0.74"}]
["hSyn-cre+Caspase3 vs. hSyn-cre",0.6857,"-7.636 to 9.008","ns",0.9957,{"v":0.1272900442539716,"d":"0.13"},{"v":0.16972005900529546,"d":"0.17"}]
[]
[]
[]
[]
["Figure S17a-0.04g"]
["Comparison","Mean Diff.","95.00% CI of diff.","P Value Summary","Adjusted P Value","Cohen's d","Hedges' g"]
["MBP-cre+Caspase3 vs. MBP-cre",17.06,"9.546 to 24.58","****","<0.0001",{"v":3.50620901474216,"d":"3.51"},{"v":4.674945352989546,"d":"4.67"}]
["MBP-cre+Caspase3 vs. hSyn-cre+Caspase3",21.74,"14.52 to 28.96","****","<0.0001",{"v":4.469430307058543,"d":"4.47"},{"v":5.95924040941139,"d":"5.96"}]
["MBP-cre+Caspase3 vs. hSyn-cre",21.86,"14.35 to 29.38","****","<0.0001",{"v":4.492715654294468,"d":"4.49"},{"v":5.99028753905929,"d":"5.99"}]
["MBP-cre vs. hSyn-cre+Caspase3",4.681,"-2.835 to 12.20","ns",0.333,{"v":0.9620494957800735,"d":"0.96"},{"v":1.282732661040098,"d":"1.28"}]
["MBP-cre vs. hSyn-cre",4.8,"-2.999 to 12.60","ns",0.343,{"v":0.9865721937024575,"d":"0.99"},{"v":1.3154295916032765,"d":"1.32"}]
["hSyn-cre+Caspase3 vs. hSyn-cre",0.119,"-7.396 to 7.635","ns",">0.9999",{"v":0.024457143772234295,"d":"0.02"},{"v":0.032609525029645724,"d":"0.03"}]
[]
[]
[]
[]
["Figure S17a-0.07g"]
["Comparison","Mean Diff.","95.00% CI of diff.","P Value Summary","Adjusted P Value","Cohen's d","Hedges' g"]
["MBP-cre+Caspase3 vs. MBP-cre",27.74,"14.86 to 40.61","****","<0.0001",{"v":3.329689596748337,"d":"3.33"},{"v":4.4395861289977825,"d":"4.44"}]
["MBP-cre+Caspase3 vs. hSyn-cre+Caspase3",32.37,"20.00 to 44.74","****","<0.0001",{"v":3.8847087564908747,"d":"3.88"},{"v":5.179611675321166,"d":"5.18"}]
["MBP-cre+Caspase3 vs. hSyn-cre",29.59,"16.71 to 42.46","****","<0.0001",{"v":3.551748924577624,"d":"3.55"},{"v":4.735665232770165,"d":"4.74"}]
["MBP-cre vs. hSyn-cre+Caspase3",4.636,"-8.236 to 17.51","ns",0.7509,{"v":0.5564686723332838,"d":"0.56"},{"v":0.7419582297777116,"d":"0.74"}]
["MBP-cre vs. hSyn-cre",1.85,"-11.51 to 15.21","ns",0.9802,{"v":0.22205779584216376,"d":"0.22"},{"v":0.296077061122885,"d":"0.30"}]
["hSyn-cre+Caspase3 vs. hSyn-cre",-2.786,"-15.66 to 10.09","ns",0.9307,{"v":-0.3344093445039967,"d":"-0.33"},{"v":-0.44587912600532886,"d":"-0.45"}]
[]
[]
[]
[]
["Figure S17a-0.16g"]
["Comparison","Mean Diff.","95.00% CI of diff.","P Value Summary","Adjusted P Value","Cohen's d","Hedges' g"]
["MBP-cre+Caspase3 vs. MBP-cre",25.93,"9.800 to 42.06","**",0.001,{"v":2.4838361298296086,"d":"2.48"},{"v":3.3117815064394778,"d":"3.31"}]
["MBP-cre+Caspase3 vs. hSyn-cre+Caspase3",33.06,"17.56 to 48.55","****","<0.0001",{"v":3.1669020278224913,"d":"3.17"},{"v":4.2225360370966545,"d":"4.22"}]
["MBP-cre+Caspase3 vs. hSyn-cre",31.2,"15.07 to 47.32","***",0.0001,{"v":2.9886497204274503,"d":"2.99"},{"v":3.984866293903267,"d":"3.98"}]
["MBP-cre vs. hSyn-cre+Caspase3",7.129,"0.9560 to 13.30","*",0.0228,{"v":1.658114321255597,"d":"1.66"},{"v":2.2108190950074627,"d":"2.21"}]
["MBP-cre vs. hSyn-cre",5.267,"-1.139 to 11.67","ns",0.1169,{"v":1.225182863747687,"d":"1.23"},{"v":1.6335771516635824,"d":"1.63"}]
["hSyn-cre+Caspase3 vs. hSyn-cre",-1.862,"-8.034 to 4.311","ns",0.7212,{"v":-0.43307741144310874,"d":"-0.43"},{"v":-0.5774365485908116,"d":"-0.58"}]
[]
[]
[]
[]
["Figure S17a-0.4g"]
["Comparison","Mean Diff.","95.00% CI of diff.","P Value Summary","Adjusted P Value","Cohen's d","Hedges' g"]
["MBP-cre+Caspase3 vs. MBP-cre",17.93,"1.858 to 34.00","*",0.0251,{"v":1.723450435372645,"d":"1.72"},{"v":2.2979339138301933,"d":"2.30"}]
["MBP-cre+Caspase3 vs. hSyn-cre+Caspase3",29.91,"14.47 to 45.35","***",0.0001,{"v":2.8754617789930266,"d":"2.88"},{"v":3.8339490386573685,"d":"3.83"}]
["MBP-cre+Caspase3 vs. hSyn-cre",22.26,"6.191 to 38.33","**",0.0045,{"v":2.139654584015342,"d":"2.14"},{"v":2.8528727786871224,"d":"2.85"}]
["MBP-cre vs. hSyn-cre+Caspase3",11.99,"2.999 to 20.97","**",0.0089,{"v":1.9151938549433247,"d":"1.92"},{"v":2.5535918065910996,"d":"2.55"}]
["MBP-cre vs. hSyn-cre",4.333,"-4.993 to 13.66","ns",0.4707,{"v":0.692213258549709,"d":"0.69"},{"v":0.922951011399612,"d":"0.92"}]
["hSyn-cre+Caspase3 vs. hSyn-cre",-7.652,"-16.64 to 1.335","ns",0.1021,{"v":-1.2222738430380584,"d":"-1.22"},{"v":-1.6296984573840778,"d":"-1.63"}]
[]
[]
[]
[]
["Figure S17b-0.008g"]
["Comparison","Mean Diff.","95.00% CI of diff.","P Value Summary","Adjusted P Value","Cohen's d","Hedges' g"]
["MBP-cre+Caspase3 vs. MBP-cre",0.1238,"-0.3464 to 0.5940","ns",0.8835,{"v":0.4068278893367178,"d":"0.41"},{"v":0.5424371857822904,"d":"0.54"}]
["MBP-cre+Caspase3 vs. hSyn-cre+Caspase3",0.02857,"-0.4232 to 0.4803","ns",0.998,{"v":0.09386175392056502,"d":"0.09"},{"v":0.12514900522742,"d":"0.13"}]
["MBP-cre+Caspase3 vs. hSyn-cre",-0.009524,"-0.4797 to 0.4607","ns",">0.9999",{"v":-0.0312974864139168,"d":"-0.03"},{"v":-0.0417299818852224,"d":"-0.04"}]
["MBP-cre vs. hSyn-cre+Caspase3",-0.09524,"-0.5655 to 0.3750","ns",0.9421,{"v":-0.3129748641391681,"d":"-0.31"},{"v":-0.4172998188522241,"d":"-0.42"}]
["MBP-cre vs. hSyn-cre",-0.1333,"-0.6213 to 0.3546","ns",0.872,{"v":-0.43802385249275533,"d":"-0.44"},{"v":-0.5840318033236738,"d":"-0.58"}]
["hSyn-cre+Caspase3 vs. hSyn-cre",-0.0381,"-0.5083 to 0.4321","ns",0.9959,{"v":-0.12520309033706745,"d":"-0.13"},{"v":-0.1669374537827566,"d":"-0.17"}]
[]
[]
[]
[]
["Figure S17b-0.02g"]
["Comparison","Mean Diff.","95.00% CI of diff.","P Value Summary","Adjusted P Value","Cohen's d","Hedges' g"]
["MBP-cre+Caspase3 vs. MBP-cre",0.3,"-0.2257 to 0.8257","ns",0.4074,{"v":0.8816935661873009,"d":"0.88"},{"v":1.1755914215830678,"d":"1.18"}]
["MBP-cre+Caspase3 vs. hSyn-cre+Caspase3",0.3714,"-0.1337 to 0.8765","ns",0.2035,{"v":1.091377957628086,"d":"1.09"},{"v":1.4551706101707813,"d":"1.46"}]
["MBP-cre+Caspase3 vs. hSyn-cre",0.1333,"-0.3924 to 0.6591","ns",0.8943,{"v":0.39176584124255737,"d":"0.39"},{"v":0.5223544549900765,"d":"0.52"}]
["MBP-cre vs. hSyn-cre+Caspase3",0.07143,"-0.4543 to 0.5971","ns",0.9812,{"v":0.20993123810919634,"d":"0.21"},{"v":0.2799083174789284,"d":"0.28"}]
["MBP-cre vs. hSyn-cre",-0.1667,"-0.7122 to 0.3789","ns",0.8308,{"v":-0.4897928237858046,"d":"-0.49"},{"v":-0.6530570983810727,"d":"-0.65"}]
["hSyn-cre+Caspase3 vs. hSyn-cre",-0.2381,"-0.7638 to 0.2876","ns",0.5983,{"v":-0.6997707936973212,"d":"-0.70"},{"v":-0.9330277249297616,"d":"-0.93"}]
[]
[]
[]
[]
["Figure S17b-0.04g"]
["Comparison","Mean Diff.","95.00% CI of diff.","P Value Summary","Adjusted P Value","Cohen's d","Hedges' g"]
["MBP-cre+Caspase3 vs. MBP-cre",0.06667,"-0.3708 to 0.5041","ns",0.9739,{"v":0.23550326251691006,"d":"0.24"},{"v":0.31400435002254673,"d":"0.31"}]
["MBP-cre+Caspase3 vs. hSyn-cre+Caspase3",0.2429,"-0.1774 to 0.6631","ns",0.3966,{"v":0.8581329234702959,"d":"0.86"},{"v":1.1441772312937277,"d":"1.14"}]
["MBP-cre+Caspase3 vs. hSyn-cre",0.1667,"-0.2708 to 0.6041","ns",0.7178,{"v":0.5888464656002537,"d":"0.59"},{"v":0.7851286208003382,"d":"0.79"}]
["MBP-cre vs. hSyn-cre+Caspase3",0.1762,"-0.2612 to 0.6136","ns",0.6823,{"v":0.6224040026320617,"d":"0.62"},{"v":0.8298720035094156,"d":"0.83"}]
["MBP-cre vs. hSyn-cre",0.1,"-0.3539 to 0.5539","ns",0.9273,{"v":0.3531194306970188,"d":"0.35"},{"v":0.47082590759602505,"d":"0.47"}]
["hSyn-cre+Caspase3 vs. hSyn-cre",-0.07619,"-0.5136 to 0.3612","ns",0.9619,{"v":-0.26913144699510094,"d":"-0.27"},{"v":-0.35884192932680126,"d":"-0.36"}]
[]
[]
[]
[]
["Figure S17b-0.07g"]
["Comparison","Mean Diff.","95.00% CI of diff.","P Value Summary","Adjusted P Value","Cohen's d","Hedges' g"]
["MBP-cre+Caspase3 vs. MBP-cre",0.3429,"-0.1158 to 0.8015","ns",0.1921,{"v":1.1547938786113174,"d":"1.15"},{"v":1.5397251714817566,"d":"1.54"}]
["MBP-cre+Caspase3 vs. hSyn-cre+Caspase3",0.4571,"0.01649 to 0.8978","*",0.0401,{"v":1.5395729512056608,"d":"1.54"},{"v":2.052763934940881,"d":"2.05"}]
["MBP-cre+Caspase3 vs. hSyn-cre",0.4762,"0.01754 to 0.9348","*",0.04,{"v":1.6037120005678316,"d":"1.60"},{"v":2.138282667423775,"d":"2.14"}]
["MBP-cre vs. hSyn-cre+Caspase3",0.1143,"-0.3444 to 0.5729","ns",0.8991,{"v":0.3849312928704392,"d":"0.38"},{"v":0.5132417238272522,"d":"0.51"}]
["MBP-cre vs. hSyn-cre",0.1333,"-0.3426 to 0.6093","ns",0.8636,{"v":0.44901278228108,"d":"0.45"},{"v":0.5986837097081066,"d":"0.60"}]
["hSyn-cre+Caspase3 vs. hSyn-cre",0.01905,"-0.4396 to 0.4777","ns",0.9994,{"v":0.06415521547840654,"d":"0.06"},{"v":0.08554028730454205,"d":"0.09"}]
[]
[]
[]
[]
["Figure S17b-0.16g"]
["Comparison","Mean Diff.","95.00% CI of diff.","P Value Summary","Adjusted P Value","Cohen's d","Hedges' g"]
["MBP-cre+Caspase3 vs. MBP-cre",0.119,"-0.4846 to 0.7227","ns",0.9462,{"v":0.3045330643580415,"d":"0.30"},{"v":0.406044085810722,"d":"0.41"}]
["MBP-cre+Caspase3 vs. hSyn-cre+Caspase3",0.3429,"-0.2371 to 0.9228","ns",0.3772,{"v":0.8773947329034976,"d":"0.88"},{"v":1.16985964387133,"d":"1.17"}]
["MBP-cre+Caspase3 vs. hSyn-cre",0.2857,"-0.3179 to 0.8894","ns",0.5639,{"v":0.7311352645974157,"d":"0.73"},{"v":0.9748470194632209,"d":"0.97"}]
["MBP-cre vs. hSyn-cre+Caspase3",0.2238,"-0.3799 to 0.8275","ns",0.7342,{"v":0.5727268891036109,"d":"0.57"},{"v":0.7636358521381479,"d":"0.76"}]
["MBP-cre vs. hSyn-cre",0.1667,"-0.4598 to 0.7931","ns",0.8804,{"v":0.426614760079391,"d":"0.43"},{"v":0.5688196801058546,"d":"0.57"}]
["hSyn-cre+Caspase3 vs. hSyn-cre",-0.05714,"-0.6608 to 0.5465","ns",0.9935,{"v":-0.14622705291948315,"d":"-0.15"},{"v":-0.1949694038926442,"d":"-0.19"}]
[]
[]
[]
[]
["Figure S17b-0.4g"]
["Comparison","Mean Diff.","95.00% CI of diff.","P Value Summary","Adjusted P Value","Cohen's d","Hedges' g"]
["MBP-cre+Caspase3 vs. MBP-cre",0.1571,"-0.3165 to 0.6308","ns",0.7938,{"v":0.5123233961635624,"d":"0.51"},{"v":0.6830978615514165,"d":"0.68"}]
["MBP-cre+Caspase3 vs. hSyn-cre+Caspase3",0.3143,"-0.1407 to 0.7693","ns",0.2496,{"v":1.025017795400549,"d":"1.03"},{"v":1.3666903938673987,"d":"1.37"}]
["MBP-cre+Caspase3 vs. hSyn-cre",0.1905,"-0.2831 to 0.6641","ns",0.6833,{"v":0.6212451111976998,"d":"0.62"},{"v":0.8283268149302663,"d":"0.83"}]
["MBP-cre vs. hSyn-cre+Caspase3",0.1571,"-0.3165 to 0.6308","ns",0.7938,{"v":0.5123233961635624,"d":"0.51"},{"v":0.6830978615514165,"d":"0.68"}]
["MBP-cre vs. hSyn-cre",0.03333,"-0.4582 to 0.5248","ns",0.9976,{"v":0.10871799136774139,"d":"0.11"},{"v":0.14495732182365517,"d":"0.14"}]
["hSyn-cre+Caspase3 vs. hSyn-cre",-0.1238,"-0.5974 to 0.3498","ns",0.8857,{"v":-0.40372779404868886,"d":"-0.40"},{"v":-0.5383037253982518,"d":"-0.54"}]

{"sheet":"Figure S18","index":12,"n_rows":99,"n_cols":7,"rows_kept":99,"merged":[[1,0,1,6],[10,0,10,6],[19,0,19,6],[28,0,28,6],[37,0,37,6],[46,0,46,6],[55,0,55,6],[63,0,63,6],[71,0,71,6],[79,0,79,6],[87,0,87,6],[95,0,95,6]],"flags":["formulas_cached_only"]}
[]
["Figure S18a-0.008g"]
["Comparison (pre - after)","Mean Diff.","95.00% CI of diff.","P Value Summary","Adjusted P Value","Cohen's d","Hedges' g"]
["Vehicle",-2.15,"-19.20 to 14.90","ns",0.9838,{"v":-0.16357273280584297,"d":"-0.16"},{"v":-0.2180969770744573,"d":"-0.22"}]
["Carbamazepine",18.85,"1.804 to 35.90","*",0.0274,{"v":1.4341144248326234,"d":"1.43"},{"v":1.9121525664434977,"d":"1.91"}]
["Pregabalin",5.225,"-11.82 to 22.27","ns",0.8201,{"v":0.39751978088861833,"d":"0.40"},{"v":0.5300263745181577,"d":"0.53"}]
[]
[]
[]
[]
["Figure S18a-0.02g"]
["Comparison (pre - after)","Mean Diff.","95.00% CI of diff.","P Value Summary","Adjusted P Value","Cohen's d","Hedges' g"]
["Vehicle",0.125,"-14.21 to 14.46","ns",">0.9999",{"v":0.011306078147612158,"d":"0.01"},{"v":0.015074770863482877,"d":"0.02"}]
["Carbamazepine",35.18,"20.84 to 49.51","****","<0.0001",{"v":3.1819826338639654,"d":"3.18"},{"v":4.2426435118186205,"d":"4.24"}]
["Pregabalin",-1.775,"-16.11 to 12.56","ns",0.9846,{"v":-0.16054630969609263,"d":"-0.16"},{"v":-0.21406174626145683,"d":"-0.21"}]
[]
[]
[]
[]
["Figure S18a-0.04g"]
["Comparison (pre - after)","Mean Diff.","95.00% CI of diff.","P Value Summary","Adjusted P Value","Cohen's d","Hedges' g"]
["Vehicle",0.45,"-13.17 to 14.07","ns",0.9997,{"v":0.04285714285714286,"d":"0.04"},{"v":0.05714285714285714,"d":"0.06"}]
["Carbamazepine",28.73,"15.11 to 42.34","****","<0.0001",{"v":2.736190476190476,"d":"2.74"},{"v":3.648253968253968,"d":"3.65"}]
["Pregabalin",15.05,"1.433 to 28.67","*",0.0275,{"v":1.4333333333333333,"d":"1.43"},{"v":1.911111111111111,"d":"1.91"}]
[]
[]
[]
[]
["Figure S18a-0.07g"]
["Comparison (pre - after)","Mean Diff.","95.00% CI of diff.","P Value Summary","Adjusted P Value","Cohen's d","Hedges' g"]
["Vehicle",5.15,"-7.592 to 17.89","ns",0.6664,{"v":0.5241196824750661,"d":"0.52"},{"v":0.6988262433000881,"d":"0.70"}]
["Carbamazepine",32.85,"20.11 to 45.59","****","<0.0001",{"v":3.3431711785060045,"d":"3.34"},{"v":4.457561571341339,"d":"4.46"}]
["Pregabalin",4.975,"-7.767 to 17.72","ns",0.6894,{"v":0.506309790352127,"d":"0.51"},{"v":0.6750797204695026,"d":"0.68"}]
[]
[]
[]
[]
["Figure S18a-0.16g"]
["Comparison (pre - after)","Mean Diff.","95.00% CI of diff.","P Value Summary","Adjusted P Value","Cohen's d","Hedges' g"]
["Vehicle",1.15,"-13.44 to 15.74","ns",0.9959,{"v":0.10222222222222221,"d":"0.10"},{"v":0.13629629629629628,"d":"0.14"}]
["Carbamazepine",44.1,"29.51 to 58.69","****","<0.0001",3.92,{"v":5.226666666666667,"d":"5.23"}]
["Pregabalin",5.625,"-8.964 to 20.21","ns",0.6975,{"v":0.5,"d":"0.50"},{"v":0.6666666666666666,"d":"0.67"}]
[]
[]
[]
[]
["Figure S18a-0.4g"]
["Comparison (pre - after)","Mean Diff.","95.00% CI of diff.","P Value Summary","Adjusted P Value","Cohen's d","Hedges' g"]
["Vehicle",2.775,"-13.47 to 19.02","ns",0.9615,{"v":0.2215038314176245,"d":"0.22"},{"v":0.295338441890166,"d":"0.30"}]
["Carbamazepine",38.8,"22.55 to 55.05","****","<0.0001",{"v":3.0970625798212,"d":"3.10"},{"v":4.129416773094933,"d":"4.13"}]
["Pregabalin",23.23,"6.979 to 39.47","**",0.0039,{"v":1.8542464878671774,"d":"1.85"},{"v":2.47232865048957,"d":"2.47"}]
[]
[]
[]
[]
["Figure S18b-0.008g"]
["Comparison (pre - after)","Mean Diff.","95.00% CI of diff.","P Value Summary","Adjusted P Value","Cohen's d","Hedges' g"]
["Control",-7.4,"-28.91 to 14.11","ns",0.6363,{"v":-0.5072292522857925,"d":"-0.51"},{"v":-0.67630566971439,"d":"-0.68"}]
["QX314",21.2,"2.575 to 39.82","*",0.0262,{"v":1.4530500342700479,"d":"1.45"},{"v":1.937400045693397,"d":"1.94"}]
[]
[]
[]
[]
["Figure S18b-0.02g"]
["Comparison (pre - after)","Mean Diff.","95.00% CI of diff.","P Value Summary","Adjusted P Value","Cohen's d","Hedges' g"]
["Control",-5,"-13.94 to 3.936","ns",0.3253,{"v":-0.8247860988423225,"d":"-0.82"},{"v":-1.09971479845643,"d":"-1.10"}]
["QX314",18.83,"11.09 to 26.56","****","<0.0001",{"v":3.106235565819861,"d":"3.11"},{"v":4.141647421093148,"d":"4.14"}]
[]
[]
[]
[]
["Figure S18b-0.04g"]
["Comparison (pre - after)","Mean Diff.","95.00% CI of diff.","P Value Summary","Adjusted P Value","Cohen's d","Hedges' g"]
["Control",0.8333,"-9.862 to 11.53","ns",0.9762,{"v":0.11484983989394011,"d":"0.11"},{"v":0.1531331198585868,"d":"0.15"}]
["QX314",26.6,"17.34 to 35.86","****","<0.0001",{"v":3.6659316427783906,"d":"3.67"},{"v":4.8879088570378535,"d":"4.89"}]
[]
[]
[]
[]
["Figure S18b-0.07g"]
["Comparison (pre - after)","Mean Diff.","95.00% CI of diff.","P Value Summary","Adjusted P Value","Cohen's d","Hedges' g"]
["Control",-1.6,"-12.70 to 9.501","ns",0.9212,{"v":-0.21245640080575007,"d":"-0.21"},{"v":-0.2832752010743334,"d":"-0.28"}]
["QX314",29.75,"20.14 to 39.36","****","<0.0001",{"v":3.949814126394052,"d":"3.95"},{"v":5.266418835192069,"d":"5.27"}]
[]
[]
[]
[]
["Figure S18b-0.16g"]
["Comparison (pre - after)","Mean Diff.","95.00% CI of diff.","P Value Summary","Adjusted P Value","Cohen's d","Hedges' g"]
["Control",-3.533,"-18.40 to 11.33","ns",0.8021,{"v":-0.3504171965378711,"d":"-0.35"},{"v":-0.4672229287171615,"d":"-0.47"}]
["QX314",40.9,"28.03 to 53.77","****","<0.0001",{"v":4.0567347748462605,"d":"4.06"},{"v":5.4089796997950135,"d":"5.41"}]
[]
[]
[]
[]
["Figure S18b-0.4g"]
["Comparison (pre - after)","Mean Diff.","95.00% CI of diff.","P Value Summary","Adjusted P Value","Cohen's d","Hedges' g"]
["Control",1.967,"-8.117 to 12.05","ns",0.8613,{"v":0.28750581759392246,"d":"0.29"},{"v":0.38334109012522993,"d":"0.38"}]
["QX314",39.38,"30.64 to 48.11","****","<0.0001",{"v":5.757309941520468,"d":"5.76"},{"v":7.6764132553606235,"d":"7.68"}]