{"text_format":"3","workbook":"xlsx","n_sheets":11,"sheets":["Legends","Supplemental Table 1","Supplemental Table 2","Supplemental Table 3","Supplemental Table 4","Supplemental Table 5","Supplemental Table 6","Supplemental Table 7","Supplemental Table 8","Supplemental Table 9","Supplemental Table 10"],"read":"whole","date_system":"1900"}

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["Supplemental Table","Title","Legend/Description"]
["Supplemental Table 1","Study cohort","Epithelial (ET and BE) and stromal (ES and BS) LMD enriched samples were organized into two sets of multiplexes. Biological replicates representing two specimen blocks obtained from the same patient are denoted as “BioNB” (Biological replicate, new block)."]
["Supplemental Table 2","Epithelial protein matrix","Abundance matrix of 6,818 proteins co-quantified across all epithelial samples (ET and BE)."]
["Supplemental Table 3","Stromal protein matrix","Abundance matrix of 4,686 proteins co-quantified across all stromal samples (ES and BS)."]
["Supplemental Table 4","Differential analysis: ET Gleason 6 vs 9","Significantly differentially abundant proteins (n=789; limma adj. p<0.05) between Gleason 6 ET versus Gleason 9 ET."]
["Supplemental Table 5","Differential analysis: ES Gleason 6 vs 9","Significantly differentially abundant proteins (n=1,244; limma adj. p<0.05) between Gleason 6 ES versus Gleason 9 ES."]
["Supplemental Table 6","Differential analysis: Gleason 6 ET vs BE","Significantly differentially abundant proteins (n=1,558; limma adj. p<0.05) between Gleason 6 ET versus Gleason 6 BE."]
["Supplemental Table 7","Differential analysis: Gleason 9 ET vs BE","Significantly differentially abundant proteins (n=1,015; limma adj. p<0.05) between Gleason 9 ET versus Gleason 9 BE."]
["Supplemental Table 8","Differential analysis: Gleason 9 ES vs BS","Significantly differentially abundant proteins (n=1,332; limma adj. p<0.05) between Gleason 9 ES versus Gleason 9 BS."]
["Supplemental Table 9","Canonical pathways","Top altered IPA canonical pathways based on comparative analyses between proteomic abundances in LMD enriched samples of Gleason 6 ET versus Gleason 6 BE, Gleason 9 ET versus Gleason 9 BE, and Gleason 9 ES versus Gleason 9 BS. The subset lists of 903, 360, 655, and 1,332 proteins depicted in the comparative venn diagrams of Figure 4 were used as input for IPA."]
["Supplemental Table 10","FDA-approved drug targets","Top altered FDA-approved drug targets based on comparative analyses between proteomic abundances in LMD enriched samples of Gleason 6 ET versus Gleason 6 BE, Gleason 9 ET versus Gleason 9 BE, and Gleason 9 ES versus Gleason 9 BS identified using IPA. The subset lists of 903, 360, 655, and 1,332 proteins depicted in the comparative venn diagrams of Figure 4 were used as input for IPA."]

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[{"$nulls":4},"Epithelial Sample Set",null,"Stromal Sample Set"]
["Gleason Score","Study ID","Parent Aliquot ID","Biological Replicate","LMD enriched tumor","LMD enriched benign epithelium","LMD enriched tumor-involved stroma","LMD enriched benign stroma"]
[9,"J4271",461829,"No","x","Not collected","x","x"]
[9,"J4270",461831,"No","x","x","x","x"]
[9,"J4274",461832,"No","x","x","x","x"]
[9,"J4273",461833,"No","x","Not collected","x","Not collected"]
[9,"J4275",461834,"No","x","Not collected","x","x"]
[9,"J4269",461835,"No","x","Not collected","x","x"]
[9,"J4268",461836,"No","x","x","x","Not collected"]
[9,"J4267",461837,"No","x","x","x","x"]
[9,"J4265",461838,"No","x","Not collected","Not collected","x"]
[9,"J4266",461839,"No","x","Not collected","Not collected","x"]
[9,"J4259",461840,"No","x","Not collected","Not collected","x"]
[9,"J4254",461841,"No","x","Not collected","x","x"]
[9,"J4258",461842,"No","x","Not collected","Not collected","Not collected"]
[9,"J4255",461843,"No","x","x","x","x"]
[9,"J4276",461844,"No","x","Not collected","x","x"]
[6,"J4250",461845,"No","x","Not collected","x","x"]
[6,"J4249",461846,"No","x","Not collected","x","x"]
[6,"J4248",461847,"BioNB","Not collected","Not collected","x","x"]
[6,"J4248",461848,"BioNB","x","x","x","x"]
[6,"J4247",461849,"BioNB","Not collected","Not collected","Not collected","x"]
[6,"J4247",461850,"BioNB","Not collected","Not collected","Not collected","x"]
[6,"J4246",461851,"BioNB","x","x","x","x"]
[6,"J4246",461852,"BioNB","x","x","x","x"]
[6,"J4251",461853,"No","x","x","Not collected","x"]
[6,"J4257",461854,"BioNB","x","Not collected","x","x"]
[6,"J4257",461855,"BioNB","x","x","x","x"]
[6,"J4253",461856,"BioNB","x","x","x","Not collected"]
[6,"J4253",461857,"BioNB","x","x","x","x"]
[6,"J4256",461858,"No","x","x","x","x"]
[6,"J4252",461859,"No","x","x","x","x"]
[6,"J4261",461860,"BioNB","x","x","x","x"]
[6,"J4261",461861,"BioNB","x","x","x","x"]
[6,"J4262",461862,"BioNB","x","x","Not collected","x"]
[6,"J4262",461863,"BioNB","x","x","x","x"]
[6,"J4263",461864,"BioNB","x","x","x","x"]
[6,"J4263",461865,"BioNB","x","x","Not collected","x"]
[6,"J4264",461866,"No","x","x","Not collected","x"]
[6,"J4260",461867,"No","Not collected","Not collected","x","x"]
[{"$nulls":3},"TOTAL:",34,21,28,34]

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{"sheet":"Supplemental Table 3","index":3,"n_rows":4686,"n_cols":64,"rows_kept":1125,"cut":true,"bounds":{"rows_first":500,"rows_last":125,"rows_between":500,"halvings":2}}
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{"sheet":"Supplemental Table 4","index":4,"n_rows":790,"n_cols":42,"rows_kept":790}
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{"sheet":"Supplemental Table 5","index":5,"n_rows":1245,"n_cols":36,"rows_kept":1245}
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{"sheet":"Supplemental Table 6","index":6,"n_rows":1559,"n_cols":43,"rows_kept":1559}
["Accession","Gene","logFC Gleason 6_SubcollectionEnriched_tumor vs Gleason 6_SubcollectionBenign_epithelium","AveExpr","t","P.Value","adj.P.Val","B","Subcollection-Enriched_tumor;J4249.461846__Enriched.tumor","Subcollection-Benign_epithelium;J4251.461853__Benign.epithelium","Subcollection-Enriched_tumor;J4261.461860__Enriched.tumor","Subcollection-Benign_epithelium;J4261.461860__Benign.epithelium","Subcollection-Enriched_tumor;J4253.461857__Enriched.tumor","Subcollection-Benign_epithelium;J4262.461863__Benign.epithelium","Subcollection-Benign_epithelium;J4253.461856__Benign.epithelium","Subcollection-Enriched_tumor;J4251.461853__Enriched.tumor","Subcollection-Enriched_tumor;J4261.461861__Enriched.tumor","Subcollection-Benign_epithelium;J4261.461861__Benign.epithelium","Subcollection-Enriched_tumor;J4263.461865__Enriched.tumor","Subcollection-Benign_epithelium;J4263.461865__Benign.epithelium","Subcollection-Enriched_tumor;J4246.461851__Enriched.tumor","Subcollection-Benign_epithelium;J4246.461851__Benign.epithelium","Subcollection-Benign_epithelium;J4246.461852__Benign.epithelium.1","Subcollection-Benign_epithelium;J4253.461857__Benign.epithelium","Subcollection-Benign_epithelium;J4256.461858__Benign.epithelium","Subcollection-Enriched_tumor;J4248.461848__Enriched.tumor","Subcollection-Benign_epithelium;J4248.461848__Benign.epithelium","Subcollection-Enriched_tumor;J4253.461856__Enriched.tumor","Subcollection-Enriched_tumor;J4257.461855__Enriched.tumor","Subcollection-Benign_epithelium;J4257.461855__Benign.epithelium","Subcollection-Enriched_tumor;J4262.461863__Enriched.tumor","Subcollection-Enriched_tumor;J4250.461845__Enriched.tumor","Subcollection-Benign_epithelium;J4252.461859__Benign.epithelium","Subcollection-Enriched_tumor;J4256.461858__Enriched.tumor","Subcollection-Enriched_tumor;J4263.461864__Enriched.tumor","Subcollection-Benign_epithelium;J4263.461864__Benign.epithelium","Subcollection-Enriched_tumor;J4246.461852__Enriched.tumor","Subcollection-Enriched_tumor;J4257.461854__Enriched.tumor","Subcollection-Enriched_tumor;J4262.461862__Enriched.tumor","Subcollection-Benign_epithelium;J4262.461862__Benign.epithelium","Subcollection-Enriched_tumor;J4264.461866__Enriched.tumor","Subcollection-Benign_epithelium;J4264.461866__Benign.epithelium","Subcollection-Enriched_tumor;J4252.461859__Enriched.tumor"]
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{"sheet":"Supplemental Table 7","index":7,"n_rows":1016,"n_cols":28,"rows_kept":1016}
["Accession","Gene","logFC Gleason 9_SubcollectionEnriched_tumor vs Gleason 9_SubcollectionBenign_epithelium","AveExpr","t","P.Value","adj.P.Val","B","Subcollection-Enriched_tumor;J4274.461832__Enriched.tumor","Subcollection-Enriched_tumor;J4255.461843__Enriched.tumor","Subcollection-Benign_epithelium;J4267.461837__Benign.epithelium","Subcollection-Enriched_tumor;J4268.461836__Enriched.tumor","Subcollection-Enriched_tumor;J4276.461844__Enriched.tumor","Subcollection-Enriched_tumor;J4259.461840__Enriched.tumor","Subcollection-Enriched_tumor;J4265.461838__Enriched.tumor","Subcollection-Enriched_tumor;J4270.461831__Enriched.tumor","Subcollection-Enriched_tumor;J4271.461829__Enriched.tumor","Subcollection-Benign_epithelium;J4274.461832__Benign.epithelium","Subcollection-Enriched_tumor;J4273.461833__Enriched.tumor","Subcollection-Enriched_tumor;J4254.461841__Enriched.tumor","Subcollection-Benign_epithelium;J4255.461843__Benign.epithelium","Subcollection-Enriched_tumor;J4266.461839__Enriched.tumor","Subcollection-Enriched_tumor;J4267.461837__Enriched.tumor","Subcollection-Enriched_tumor;J4275.461834__Enriched.tumor","Subcollection-Enriched_tumor;J4258.461842__Enriched.tumor","Subcollection-Benign_epithelium;J4268.461836__Benign.epithelium","Subcollection-Benign_epithelium;J4270.461831__Benign.epithelium","Subcollection-Enriched_tumor;J4269.461835__Enriched.tumor"]
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{"sheet":"Supplemental Table 8","index":8,"n_rows":1333,"n_cols":31,"rows_kept":1333}
["Accession","Gene","logFC SubcollectionTumor_involved_stroma vs SubcollectionBenign_stroma","AveExpr","t","P.Value","adj.P.Val","B","Subcollection-Benign_stroma;J4275.461834__Benign.stroma","Subcollection-Tumor_involved_stroma;J4255.461843__Tumor.involved.stroma","Subcollection-Benign_stroma;J4254.461841__Benign.stroma","Subcollection-Benign_stroma;J4259.461840__Benign.stroma","Subcollection-Benign_stroma;J4269.461835__Benign.stroma","Subcollection-Tumor_involved_stroma;J4275.461834__Tumor.involved.stroma","Subcollection-Benign_stroma;J4276.461844__Benign.stroma","Subcollection-Benign_stroma;J4266.461839__Benign.stroma","Subcollection-Tumor_involved_stroma;J4274.461832__Tumor.involved.stroma","Subcollection-Tumor_involved_stroma;J4273.461833__Tumor.involved.stroma","Subcollection-Tumor_involved_stroma;J4269.461835__Tumor.involved.stroma","Subcollection-Tumor_involved_stroma;J4276.461844__Tumor.involved.stroma","Subcollection-Benign_stroma;J4274.461832__Benign.stroma","Subcollection-Benign_stroma;J4271.461829__Benign.stroma","Subcollection-Benign_stroma;J4267.461837__Benign.stroma","Subcollection-Benign_stroma;J4265.461838__Benign.stroma","Subcollection-Tumor_involved_stroma;J4268.461836__Tumor.involved.stroma","Subcollection-Tumor_involved_stroma;J4254.461841__Tumor.involved.stroma","Subcollection-Tumor_involved_stroma;J4270.461831__Tumor.involved.stroma","Subcollection-Benign_stroma;J4255.461843__Benign.stroma","Subcollection-Tumor_involved_stroma;J4271.461829__Tumor.involved.stroma","Subcollection-Tumor_involved_stroma;J4267.461837__Tumor.involved.stroma","Subcollection-Benign_stroma;J4270.461831__Benign.stroma"]
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{"sheet":"Supplemental Table 9","index":9,"n_rows":224,"n_cols":25,"rows_kept":224,"merged":[[0,0,0,4],[0,5,0,9],[0,10,0,14],[0,15,0,19],[0,20,0,24]]}
["Canonical Pathways: LogFC(Gleason6tumorVSGleason6benignepithelium)",{"$nulls":4},"Canonical Pathways: LogFC(Gleason9tumorVSGleason9benignepithelium)",{"$nulls":4},"Canonical Pathways: Overlap LogFC(tumorVSbenignepithelium), Gleason 6 values",{"$nulls":4},"Canonical Pathways: Overlap LogFC(tumorVSbenignepithelium), Gleason 9 values",{"$nulls":4},"Canonical Pathways: LogFC(Gleason9involvedstromaVSGleason9benignstroma)"]
["Ingenuity Canonical Pathways"," -log(p-value)","Ratio","z-score","Molecules","Ingenuity Canonical Pathways"," -log(p-value)","Ratio","z-score","Molecules","Ingenuity Canonical Pathways"," -log(p-value)","Ratio","z-score","Molecules","Ingenuity Canonical Pathways"," -log(p-value)","Ratio","z-score","Molecules","Ingenuity Canonical Pathways"," -log(p-value)","Ratio","z-score","Molecules"]
["GP6 Signaling Pathway",5.7,0.142,4.123,"COL15A1,COL1A1,COL1A2,COL21A1,COL3A1,COL5A1,COL5A2,COL6A1,COL6A2,COL6A3,FGG,LAMA2,LAMB1,LAMB2,LAMC1,LAMC3,TLN1,VAV2","RhoGDI Signaling",1.32,0.0326,2.449,"ARHGAP6,ARHGEF18,ARPC1A,ARPC3,GNAI3,ITGA2,RDX","RhoGDI Signaling",2.08,0.0605,2.449,"ARHGEF3,ARPC4,GNAI2,GNG12,GNG4,ITGA1,ITGA3,ITGA6,ITGB4,MYH14,PI4KA,PIP4K2C,ROCK1","RhoGDI Signaling",2.08,0.0605,2.449,"ARHGEF3,ARPC4,GNAI2,GNG12,GNG4,ITGA1,ITGA3,ITGA6,ITGB4,MYH14,PI4KA,PIP4K2C,ROCK1","Processing of Capped Intron-Containing Pre-mRNA",59.7,0.373,10.344,"AAAS,ALYREF,AQR,CASC3,CCAR1,CCDC12,CHERP,CHTOP,CPSF1,CPSF2,CPSF6,CPSF7,CSTF1,CSTF3,CWC15,DDX23,DDX39B,DDX46,DDX5,DHX15,DHX38,DHX9,EIF4A3,EIF4E,GTF2F1,HNRNPA1,HNRNPA2B1,HNRNPA3,HNRNPC,HNRNPD,HNRNPF,HNRNPH2,HNRNPK,HNRNPM,HNRNPR,IK,LOC102724594/U2AF1,LSM3,LSM4,LSM6,LSM7,LSM8,LUC7L3,METTL3,NCBP1,NUP210,NUP58,NUP98,NXF1,PABPN1,PCBP1,PHF5A,PNN,POLR2D,POLR2H,PPIE,PPIH,PPP1R8,PRPF3,PRPF40A,PRPF4B,PRPF6,PRPF8,PTBP1,RANBP2,RBM10,RBM17,RBM22,RBM25,RBM39,RBM5,RBMX,SAP18,SARNP,SEC13,SF3B1,SF3B2,SF3B6,SNRNP200,SNRNP40,SNRNP70,SNRPA,SNRPA1,SNRPB2,SNRPD1,SNRPD3,SNU13,SRRM1,SRRM2,SRRT,SRSF1,SRSF10,SRSF2,SRSF3,SRSF4,SRSF5,SRSF6,SRSF7,SRSF9,TCERG1,THOC6,TRA2B,USP39,WBP11,XAB2,YBX1,ZC3H11A"]
["tRNA Charging",12.4,0.41,4,"CARS2,DARS1,EPRS1,GARS1,IARS1,LARS1,MARS1,MARS2,NARS2,RARS1,TARS1,TARS2,TARS3,VARS1,WARS2,YARS1","Apoptosis Signaling",2.27,0.0577,2.236,"CYCS,HTRA2,KRAS,MAP2K2,MAP4K4,NRAS","Salvage Pathways of Pyrimidine Ribonucleotides",1.68,0.0714,1.134,"APOBEC3G,CDK1,NME1,NME2,PKN1,PRKCD,UCK2","Salvage Pathways of Pyrimidine Ribonucleotides",1.68,0.0714,1.134,"APOBEC3G,CDK1,NME1,NME2,PKN1,PRKCD,UCK2","Neutrophil degranulation",25.8,0.193,9.383,"ACAA1,ACLY,AGA,AP2A2,APRT,ARHGAP45,ARPC5,ARSA,ASAH1,ATG7,ATP6V0A1,BIN2,CANT1,CNN2,COMMD9,COPB1,COTL1,CSTB,CTSD,CTSZ,CYBB,DDX3X,DIAPH1,DNAJC3,DPP7,DSC1,DSP,ENPP4,ERP44,FABP5,FLG2,FUCA1,FUCA2,GAA,GALNS,GGH,GHDC,GLA,GM2A,GNS,GUSB,HEBP2,HEXB,HRNR,HSP90AA1,HSP90AB1,IDH1,IGF2R,IQGAP2,ITGAX,ITGB2,JUP,LAMP1,LAMP2,LAMTOR3,MAN2B1,MANBA,NAPRT,NCKAP1L,NME2,OSTF1,PA2G4,PFKL,PGM2,PNP,PPIA,PPIE,PRDX4,PSAP,PSMA2,PSMA5,PSMB1,PSMC2,PSMD11,PSMD12,PSMD14,PSMD2,PSMD7,PTPN6,PYGB,RAB27A,RAB3A,RAB3D,RAB6A,RNASET2,S100A7,SCAMP1,SRP14,STK10,TOLLIP,VCP,XRCC6"]
["Oxidative Phosphorylation",2.01,0.0917,3.162,"ATPAF1,ATPAF2,COX6B1,COX7A2L,CYC1,UQCRB,UQCRC1,UQCRC2,UQCRFS1,UQCRH","PPAR Signaling",1.61,0.0467,1.342,"KRAS,MAP2K2,MAP4K4,NRAS,TAB1","Cardiac β-adrenergic Signaling",1.97,0.0632,0.378,"APEX1,GNAI2,GNG12,GNG4,PALM2AKAP2,PDE11A,PPP1R14B,PPP1R3D,PPP2R5A,SMPDL3B,TDP2","Cardiac β-adrenergic Signaling",1.97,0.0632,0.378,"APEX1,GNAI2,GNG12,GNG4,PALM2AKAP2,PDE11A,PPP1R14B,PPP1R3D,PPP2R5A,SMPDL3B,TDP2","Major pathway of rRNA processing in the nucleolus and cytosol",32.3,0.339,7.937,"BOP1,BYSL,CSNK1D,DDX21,EBNA1BP2,FBL,NCL,NOL9,NOP56,NOP58,PES1,RBM28,RPL10A,RPL13,RPL13A,RPL14,RPL17,RPL18A,RPL19,RPL23,RPL23A,RPL24,RPL26,RPL27,RPL28,RPL3,RPL30,RPL31,RPL32,RPL34,RPL35A,RPL36,RPL38,RPL4,RPL5,RPL6,RPL7,RPL7A,RPL8,RPS10,RPS11,RPS13,RPS15A,RPS16,RPS18,RPS19,RPS20,RPS23,RPS24,RPS25,RPS26,RPS28,RPS3,RPS3A,RPS4X,RPS4Y1,RPS5,RPS7,RPS8,RPS9,SNU13,TSR1,UTP20"]
["Intrinsic Prothrombin Activation Pathway",3.74,0.19,2.121,"COL1A1,COL1A2,COL3A1,F13A1,F2,F5,FGG,PROS1","Necroptosis Signaling Pathway",1.97,0.0446,1.134,"DAPK1,SLC25A13,TAB1,TOMM40,TOMM5,TOMM6,TOMM7","Sirtuin Signaling Pathway",1.71,0.0514,0.378,"ADAM10,AGTRAP,APEX1,ATG16L1,H1-0,H1-5,POLR1A,POLR1B,POLR1E,RRP9,TIMM44,TIMM8B,TOMM22,TRIM28,TUBA4A","Sirtuin Signaling Pathway",1.71,0.0514,0.378,"ADAM10,AGTRAP,APEX1,ATG16L1,H1-0,H1-5,POLR1A,POLR1B,POLR1E,RRP9,TIMM44,TIMM8B,TOMM22,TRIM28,TUBA4A","Eukaryotic Translation Initiation",43.3,0.5,7.81,"EIF2B2,EIF2B5,EIF2S1,EIF2S2,EIF3B,EIF3F,EIF3G,EIF3J,EIF4A1,EIF4B,EIF4E,EIF4G1,PABPC1,RPL10A,RPL13,RPL13A,RPL14,RPL17,RPL18A,RPL19,RPL23,RPL23A,RPL24,RPL26,RPL27,RPL28,RPL3,RPL30,RPL31,RPL32,RPL34,RPL35A,RPL36,RPL38,RPL4,RPL5,RPL6,RPL7,RPL7A,RPL8,RPS10,RPS11,RPS13,RPS15A,RPS16,RPS18,RPS19,RPS20,RPS23,RPS24,RPS25,RPS26,RPS28,RPS3,RPS3A,RPS4X,RPS4Y1,RPS5,RPS7,RPS8,RPS9"]
["Leucine Degradation I",3.62,0.444,2,"ACADM,BCAT2,IVD,MCCC1","Sirtuin Signaling Pathway",2.25,0.0377,-0.378,"ATG12,ATG5,LDHB,NDUFAF1,NOS3,SOD2,STAT3,TOMM40,TOMM5,TOMM6,TOMM7","Protein Kinase A Signaling",3.67,0.0622,-0.229,"ADD1,ADD3,APEX1,CHP1,CTNNB1,FLNB,GNAI2,GNG12,GNG4,H1-0,H1-5,KDELR3,PALM2AKAP2,PDE11A,PLCD1,PLCH2,PPP1R14B,PPP1R3D,PRKCD,PTPRA,PTPRU,ROCK1,SFN,SMPDL3B,TDP2","Protein Kinase A Signaling",3.67,0.0622,-0.229,"ADD1,ADD3,APEX1,CHP1,CTNNB1,FLNB,GNAI2,GNG12,GNG4,H1-0,H1-5,KDELR3,PALM2AKAP2,PDE11A,PLCD1,PLCH2,PPP1R14B,PPP1R3D,PRKCD,PTPRA,PTPRU,ROCK1,SFN,SMPDL3B,TDP2","Nonsense-Mediated Decay (NMD)",37.2,0.47,7.416,"CASC3,EIF4A3,EIF4G1,GSPT1,NCBP1,PABPC1,RPL10A,RPL13,RPL13A,RPL14,RPL17,RPL18A,RPL19,RPL23,RPL23A,RPL24,RPL26,RPL27,RPL28,RPL3,RPL30,RPL31,RPL32,RPL34,RPL35A,RPL36,RPL38,RPL4,RPL5,RPL6,RPL7,RPL7A,RPL8,RPS10,RPS11,RPS13,RPS15A,RPS16,RPS18,RPS19,RPS20,RPS23,RPS24,RPS25,RPS26,RPS28,RPS3,RPS3A,RPS4X,RPS4Y1,RPS5,RPS7,RPS8,RPS9,UPF1"]
["Superpathway of D-myo-inositol (1,4,5)-trisphosphate Metabolism",1.96,0.174,2,"IMPA2,MINPP1,OCRL,SYNJ2","Salvage Pathways of Pyrimidine Ribonucleotides",1.76,0.051,-0.447,"APOBEC3F,DAPK1,MAP2K2,MAP3K6,NME6","3-phosphoinositide Degradation",2.12,0.0635,-0.302,"ATP1A1,EPHX2,INPPL1,NT5C,NUDT12,NUDT9,PDXP,PPP1R14B,PPP1R3D,PPP2R5A,PTPMT1,SACM1L","3-phosphoinositide Degradation",2.12,0.0635,-0.302,"ATP1A1,EPHX2,INPPL1,NT5C,NUDT12,NUDT9,PDXP,PPP1R14B,PPP1R3D,PPP2R5A,PTPMT1,SACM1L","SRP-dependent cotranslational protein targeting to membrane",36.5,0.47,7.348,"RPL10A,RPL13,RPL13A,RPL14,RPL17,RPL18A,RPL19,RPL23,RPL23A,RPL24,RPL26,RPL27,RPL28,RPL3,RPL30,RPL31,RPL32,RPL34,RPL35A,RPL36,RPL38,RPL4,RPL5,RPL6,RPL7,RPL7A,RPL8,RPS10,RPS11,RPS13,RPS15A,RPS16,RPS18,RPS19,RPS20,RPS23,RPS24,RPS25,RPS26,RPS28,RPS3,RPS3A,RPS4X,RPS4Y1,RPS5,RPS7,RPS8,RPS9,SEC61B,SRP14,SRP68,SRP9,SSR3,SSR4"]
["Apelin Liver Signaling Pathway",1.77,0.154,2,"COL1A1,COL1A2,COL3A1,PDGFRB","Telomerase Signaling",1.61,0.0467,-1,"HDAC6,KRAS,MAP2K2,NRAS,PPP2CB","p53 Signaling",2.18,0.0816,-0.378,"CTNNB1,GNL3,PML,SCO2,SERPINB5,SFN,TP63,TRIM29","p53 Signaling",2.18,0.0816,-0.378,"CTNNB1,GNL3,PML,SCO2,SERPINB5,SFN,TP63,TRIM29","RHO GTPase cycle",13.5,0.151,7.276,"AAAS,ABI1,ARAP1,ARFGAP2,ARFGAP3,ARHGAP18,ARHGAP4,ARHGAP45,ARHGDIA,ARHGEF10L,ARHGEF2,ATP6AP1,BAIAP2,BCR,CAV1,CDC42EP1,CDC42EP5,CPD,CPSF7,CSK,CYBB,DDX39B,DEF6,DIAPH1,DOCK6,DOCK7,DSG2,DSP,FARP1,FLOT1,FLOT2,FMNL1,FMNL2,HNRNPC,HSP90AA1,HSP90AB1,HSPE1,IQGAP2,JUP,LMAN1,LMNB1,MCAM,MTR,MYO6,NCF4,NCKAP1L,PAK2,PAK4,PIK3R1,RALBP1,RBMX,RNF20,SCFD1,SCRIB,SHMT2,SRRM1,STIP1,STK10,STX5,SWAP70,TAOK3,TMEM87A,TRA2B,VAV1,VAV2,VCP,WIPF2,YKT6"]
["Acute Phase Response Signaling",5.5,0.119,1.508,"C1QC,C2,C3,C4A/C4B,C5,C9,CRABP2,F2,FGG,IRAK1,ITIH2,MAP2K6,MAP3K5,MAPK13,MAPK3,NFKB2,NOLC1,PLG,SERPINA3,SERPIND1,SERPINF1,SERPING1","VEGF Family Ligand-Receptor Interactions",1.4,0.0476,-1,"KRAS,MAP2K2,NOS3,NRAS","Ketogenesis",5.15,0.455,-0.447,"ACAT1,ACAT2,BDH1,BDH2,HMGCS1","Ketogenesis",5.15,0.455,-0.447,"ACAT1,ACAT2,BDH1,BDH2,HMGCS1","Selenoamino acid metabolism",36.1,0.486,7.211,"CTH,EEFSEC,PAPSS1,RPL10A,RPL13,RPL13A,RPL14,RPL17,RPL18A,RPL19,RPL23,RPL23A,RPL24,RPL26,RPL27,RPL28,RPL3,RPL30,RPL31,RPL32,RPL34,RPL35A,RPL36,RPL38,RPL4,RPL5,RPL6,RPL7,RPL7A,RPL8,RPS10,RPS11,RPS13,RPS15A,RPS16,RPS18,RPS19,RPS20,RPS23,RPS24,RPS25,RPS26,RPS28,RPS3,RPS3A,RPS4X,RPS4Y1,RPS5,RPS7,RPS8,RPS9,SEPHS2"]
["Purine Nucleotides De Novo Biosynthesis II",4.48,0.455,1.342,"ADSL,ADSS1,ATIC,GART,PFAS","Ceramide Signaling",1.3,0.0444,-1,"CYCS,KRAS,NRAS,PPP2CB","Endometrial Cancer Signaling",2.17,0.1,-0.447,"CTNNA1,CTNNA2,CTNNB1,MLH1,RALB,RRAS2","Endometrial Cancer Signaling",2.17,0.1,-0.447,"CTNNA1,CTNNA2,CTNNB1,MLH1,RALB,RRAS2","Response of EIF2AK4 (GCN2) to amino acid deficiency",36,0.495,7.141,"EIF2S1,EIF2S2,GCN1,RPL10A,RPL13,RPL13A,RPL14,RPL17,RPL18A,RPL19,RPL23,RPL23A,RPL24,RPL26,RPL27,RPL28,RPL3,RPL30,RPL31,RPL32,RPL34,RPL35A,RPL36,RPL38,RPL4,RPL5,RPL6,RPL7,RPL7A,RPL8,RPS10,RPS11,RPS13,RPS15A,RPS16,RPS18,RPS19,RPS20,RPS23,RPS24,RPS25,RPS26,RPS28,RPS3,RPS3A,RPS4X,RPS4Y1,RPS5,RPS7,RPS8,RPS9"]
["Pyrimidine Ribonucleotides De Novo Biosynthesis",2.62,0.167,1.342,"CAD,CANT1,CMPK1,DHX29,NUDT18,SLC25A42","Xenobiotic Metabolism General Signaling Pathway",2.18,0.049,-1.134,"ABCA2,FTL,KRAS,MAP2K2,MAP3K4,MAP3K6,NRAS","PI3K/AKT Signaling",1.95,0.0603,-0.707,"CTNNB1,HSP90AB1,IL17RA,INPPL1,ITGA1,ITGA3,ITGA6,ITGB4,PPP2R5A,RALB,RRAS2,SFN","PI3K/AKT Signaling",1.95,0.0603,-0.707,"CTNNB1,HSP90AB1,IL17RA,INPPL1,ITGA1,ITGA3,ITGA6,ITGB4,PPP2R5A,RALB,RRAS2,SFN","Eukaryotic Translation Elongation",37,0.526,7.071,"EEF1A2,EEF1D,RPL10A,RPL13,RPL13A,RPL14,RPL17,RPL18A,RPL19,RPL23,RPL23A,RPL24,RPL26,RPL27,RPL28,RPL3,RPL30,RPL31,RPL32,RPL34,RPL35A,RPL36,RPL38,RPL4,RPL5,RPL6,RPL7,RPL7A,RPL8,RPS10,RPS11,RPS13,RPS15A,RPS16,RPS18,RPS19,RPS20,RPS23,RPS24,RPS25,RPS26,RPS28,RPS3,RPS3A,RPS4X,RPS4Y1,RPS5,RPS7,RPS8,RPS9"]
["mTOR Signaling",2.06,0.0755,1.342,"ARHGAP8/PRR5-ARHGAP8,EIF3A,EIF3B,EIF3D,EIF3E,EIF3G,EIF3H,EIF3I,EIF3K,EIF3L,EIF4A1,EIF4EBP1,GNB1L,MAPK3,MLST8,RPS6KA4","Ethanol Degradation II",3.93,0.156,-1.342,"ADH1B,ADH5,ADHFE1,ALDH2,ALDH4A1","Ferroptosis Signaling Pathway",1.58,0.0635,-0.707,"ACACA,CTSB,FDFT1,GCLC,HSPB1,RALB,RRAS2,TXNRD1","Ferroptosis Signaling Pathway",1.58,0.0635,-0.707,"ACACA,CTSB,FDFT1,GCLC,HSPB1,RALB,RRAS2,TXNRD1","Eukaryotic Translation Termination",36,0.521,7,"GSPT1,RPL10A,RPL13,RPL13A,RPL14,RPL17,RPL18A,RPL19,RPL23,RPL23A,RPL24,RPL26,RPL27,RPL28,RPL3,RPL30,RPL31,RPL32,RPL34,RPL35A,RPL36,RPL38,RPL4,RPL5,RPL6,RPL7,RPL7A,RPL8,RPS10,RPS11,RPS13,RPS15A,RPS16,RPS18,RPS19,RPS20,RPS23,RPS24,RPS25,RPS26,RPS28,RPS3,RPS3A,RPS4X,RPS4Y1,RPS5,RPS7,RPS8,RPS9"]
["IL-1 Signaling",1.53,0.0851,1.342,"GNA15,GNB1L,GNG10,IRAK1,MAP2K6,MAPK13,NFKB2,PRKACB","Noradrenaline and Adrenaline Degradation",3.74,0.143,-1.342,"ADH1B,ADH5,ADHFE1,ALDH2,ALDH4A1","Remodeling of Epithelial Adherens Junctions",6.4,0.176,-1,"ACTN4,ARPC4,CTNNA1,CTNNA2,CTNNB1,CTNND1,IQGAP1,NME1,TUBA4A,TUBB,TUBB2A,TUBG1","Remodeling of Epithelial Adherens Junctions",6.4,0.176,-1,"ACTN4,ARPC4,CTNNA1,CTNNA2,CTNNB1,CTNND1,IQGAP1,NME1,TUBA4A,TUBB,TUBB2A,TUBG1","Class I MHC mediated antigen processing and presentation",5.36,0.115,6.252,"ATG7,CYBB,DCAF1,ELOC,FBXL8,FBXO22,LMO7,NCF4,NEDD4L,PDIA3,PSMA2,PSMA5,PSMA6,PSMB1,PSMB3,PSMB5,PSMB6,PSMC1,PSMC2,PSMC4,PSMC6,PSMD11,PSMD12,PSMD14,PSMD2,PSMD7,PSME2,PSME3,RNF213,SEC13,SEC23B,SEC24B,SEC24C,SEC24D,SEC31A,THOP1,TRIP12,UBA1,UBA5,UBAC1,UBE2E1,UBE2K,UBE2O"]
["Induction of Apoptosis by HIV1",1.4,0.0923,1.342,"BAX,BIRC2,CASP8,CYC1,MAP3K5,NFKB2","Serotonin Degradation",2.41,0.0735,-1.342,"ADH1B,ADH5,ADHFE1,ALDH2,ALDH4A1","Histamine Degradation",2.95,0.235,-1,"ALDH1B1,ALDH3A2,ALDH9A1,AOC1","Histamine Degradation",2.95,0.235,-1,"ALDH1B1,ALDH3A2,ALDH9A1,AOC1","RNA Polymerase II Transcription",15.9,0.262,6.245,"ALYREF,CASC3,CHTOP,CPSF1,CPSF2,CPSF6,CPSF7,CSTF1,CSTF3,DDX39B,DHX38,EIF4A3,ELOC,GTF2A1,GTF2B,GTF2F1,LOC102724594/U2AF1,NCBP1,NELFCD,PABPN1,PAF1,POLR2D,POLR2H,SARNP,SNRPD3,SRRM1,SRSF1,SRSF2,SRSF3,SRSF4,SRSF5,SRSF6,SRSF7,SRSF9,SSRP1,SUPT5H,TCEA1,THOC6,ZC3H11A"]
["Estrogen Receptor Signaling",2.63,0.0693,1.177,"ARG2,CREB1,CYC1,DLG4,EGF,EGFR,EIF2B3,EIF2B4,EIF4EBP1,GNA15,GNB1L,GNG10,IGF1R,IGF2R,MAPK3,MMP15,MMP7,MYL9,NCOR2,NFKB2,NRF1,PAK1,PLCB4,PPP1R12B,PRKACB,PRKDC,UQCRC2,UQCRFS1","Regulation of eIF4 and p70S6K Signaling",2.19,0.0447,-1.342,"AGO1,AGO2,ITGA2,KRAS,MAP2K2,NRAS,PPP2CB,RPS4Y1","Fatty Acid α-oxidation",2.67,0.2,-1,"ALDH1B1,ALDH3A2,ALDH9A1,TMLHE","Fatty Acid α-oxidation",2.67,0.2,-1,"ALDH1B1,ALDH3A2,ALDH9A1,TMLHE","Neddylation",6.62,0.142,5.916,"COMMD2,COMMD5,COMMD9,COPS7A,CUL4A,DCAF7,DCAF8,DPP3,ELOC,FBXL8,FBXO22,LMO7,NUB1,PSMA2,PSMA5,PSMA6,PSMB1,PSMB3,PSMB5,PSMB6,PSMC1,PSMC2,PSMC4,PSMC6,PSMD11,PSMD12,PSMD14,PSMD2,PSMD7,PSME2,PSME3,UCHL3,UFD1,VCP,WDR5"]
["Coagulation System",3.48,0.2,1.134,"F13A1,F2,F5,FGG,PLG,PROS1,SERPIND1","CDK5 Signaling",2.12,0.0536,-1.342,"ITGA2,KRAS,MAP2K2,NRAS,PPP1R7,PPP2CB","Ethanol Degradation IV",2.44,0.174,-1,"ACSS3,ALDH1B1,ALDH3A2,ALDH9A1","Ethanol Degradation IV",2.44,0.174,-1,"ACSS3,ALDH1B1,ALDH3A2,ALDH9A1","Deubiquitination",5.92,0.133,5.916,"ACTL6A,ADRM1,H2AC20,OTUB1,OTUD7B,PSMA2,PSMA5,PSMA6,PSMB1,PSMB3,PSMB5,PSMB6,PSMC1,PSMC2,PSMC4,PSMC6,PSMD11,PSMD12,PSMD14,PSMD2,PSMD7,PSME2,PSME3,RAD23B,SNX3,STAMBP,TGFB1,TRRAP,UCHL3,UCHL5,UFD1,USP13,USP24,USP7,VCP"]
["Death Receptor Signaling",1.48,0.0833,1.134,"ACTA1,BIRC2,CASP8,CYC1,MAP3K5,NFKB2,SPTAN1,TNFSF10","VEGF Signaling",1.74,0.0505,-1.342,"KRAS,MAP2K2,NOS3,NRAS,PTK2B","D-myo-inositol (1,4,5,6)-Tetrakisphosphate Biosynthesis",1.92,0.0621,-1,"ATP1A1,EPHX2,INPPL1,NT5C,NUDT12,NUDT9,PDXP,PPP1R14B,PPP1R3D,PPP2R5A,SACM1L","D-myo-inositol (1,4,5,6)-Tetrakisphosphate Biosynthesis",1.92,0.0621,-1,"ATP1A1,EPHX2,INPPL1,NT5C,NUDT12,NUDT9,PDXP,PPP1R14B,PPP1R3D,PPP2R5A,SACM1L","Intra-Golgi and retrograde Golgi-to-ER traffic",11.8,0.197,5.692,"ARCN1,ARF4,ARF5,ARFGAP2,ARFGAP3,ARFIP2,ARL1,COG1,COG2,COG3,COG5,COG6,COG8,COPA,COPB1,COPB2,COPE,COPG1,DYNC1I1,GBF1,GCC1,GCC2,GOLGA5,GOSR1,IGF2R,KIF13B,KIF1B,KIF5C,M6PR,MAN2A1,NSF,PAFAH1B3,PLIN3,RAB33B,RAB6A,STX16,STX5,TMED10,TUBB1,YKT6"]
["Paxillin Signaling",2.5,0.102,1,"ACTA1,ITGA5,ITGA7,ITGAX,ITGB1,MAPK13,PAK1,PAK4,PARVA,TLN1,VCL","Acute Phase Response Signaling",2.1,0.0432,-1.414,"ECSIT,FTL,KRAS,MAP2K2,NRAS,SOD2,STAT3,TAB1","D-myo-inositol (3,4,5,6)-tetrakisphosphate Biosynthesis",1.92,0.0621,-1,"ATP1A1,EPHX2,INPPL1,NT5C,NUDT12,NUDT9,PDXP,PPP1R14B,PPP1R3D,PPP2R5A,SACM1L","D-myo-inositol (3,4,5,6)-tetrakisphosphate Biosynthesis",1.92,0.0621,-1,"ATP1A1,EPHX2,INPPL1,NT5C,NUDT12,NUDT9,PDXP,PPP1R14B,PPP1R3D,PPP2R5A,SACM1L","Protein Sorting Signaling Pathway",12.4,0.213,5.516,"AP1G1,AP1M2,AP1S2,ARCN1,ARFGEF1,ARFGEF2,CLINT1,CLTA,COPA,COPB1,COPB2,COPE,COPG1,GBA1,GCC1,IGF2R,LMAN1,LYN,M6PR,MIA3,PI4K2A,PRKACB,PRKAG2,SCARB2,SEC13,SEC23B,SEC24B,SEC24C,SEC24D,SEC31A,SNX15,SNX18,SNX3,TMED10,TMED4,TMED5,VPS26B,VPS29"]
["Role of PKR in Interferon Induction and Antiviral Response",2.17,0.0882,1,"BAX,CASP8,COLEC12,CYC1,HSPA1A/HSPA1B,HSPA6,MAP2K6,MAPK13,MAPK3,NFKB2,PDGFRB,PRKRA","ERK/MAPK Signaling",1.75,0.0374,-1.414,"ITGA2,KRAS,MAP2K2,NRAS,PPP1R7,PPP2CB,PTK2B,STAT3","Ethanol Degradation II",1.92,0.125,-1,"ACSS3,ALDH1B1,ALDH3A2,ALDH9A1","Ethanol Degradation II",1.92,0.125,-1,"ACSS3,ALDH1B1,ALDH3A2,ALDH9A1","Cell Cycle Checkpoints",5.16,0.125,5.488,"BUB3,CDK2,CDKN1B,DYNC1I1,MCM3,MDC1,MRE11,NBN,NDE1,NUP98,PSMA2,PSMA5,PSMA6,PSMB1,PSMB3,PSMB5,PSMB6,PSMC1,PSMC2,PSMC4,PSMC6,PSMD11,PSMD12,PSMD14,PSMD2,PSMD7,PSME2,PSME3,RAD50,RANBP2,RCC2,SEC13,SFN,UBE2E1"]
["Pyrimidine Ribonucleotides Interconversion",2.02,0.147,1,"CANT1,CMPK1,DHX29,NUDT18,SLC25A42","RhoA Signaling",1.91,0.0484,-1.633,"ARHGAP6,ARPC1A,ARPC3,BAIAP2,PTK2B,RDX","Necroptosis Signaling Pathway",1.46,0.0573,-1,"CAPN1,CAPN5,CASP1,CHP1,PYCARD,SLC25A10,TIMM44,TIMM8B,TOMM22","Necroptosis Signaling Pathway",1.46,0.0573,-1,"CAPN1,CAPN5,CASP1,CHP1,PYCARD,SLC25A10,TIMM44,TIMM8B,TOMM22","EIF2 Signaling",30.7,0.296,5.396,"EIF2B2,EIF2B5,EIF2S1,EIF2S2,EIF3B,EIF3F,EIF3G,EIF3J,EIF4A1,EIF4A3,EIF4E,EIF4G1,EIF4G3,HNRNPA1,PABPC1,PIK3R1,PPP1CA,PTBP1,RPL10A,RPL13,RPL13A,RPL14,RPL17,RPL18A,RPL19,RPL23,RPL23A,RPL24,RPL26,RPL27,RPL28,RPL3,RPL30,RPL31,RPL32,RPL34,RPL35A,RPL36,RPL38,RPL4,RPL5,RPL6,RPL7,RPL7A,RPL8,RPS10,RPS11,RPS13,RPS15A,RPS16,RPS18,RPS19,RPS20,RPS23,RPS24,RPS25,RPS26,RPS28,RPS3,RPS3A,RPS4X,RPS4Y1,RPS5,RPS7,RPS8,RPS9,RRAS,SHC1"]
["Fatty Acid β-oxidation I",1.38,0.118,1,"ACADM,ECI2,IVD,SLC27A3","IL-6 Signaling",1.85,0.0469,-1.633,"KRAS,MAP2K2,MAP4K4,NRAS,STAT3,TAB1","Mevalonate Pathway I",4.54,0.357,-1.342,"ACAT1,ACAT2,HMGCS1,MVD,MVK","Mevalonate Pathway I",4.54,0.357,-1.342,"ACAT1,ACAT2,HMGCS1,MVD,MVK","ABC-family proteins mediated transport",13.1,0.287,5.385,"ABCB6,ABCB7,ABCC1,ABCC4,DERL1,EIF2S1,EIF2S2,ERLEC1,OS9,PSMA2,PSMA5,PSMA6,PSMB1,PSMB3,PSMB5,PSMB6,PSMC1,PSMC2,PSMC4,PSMC6,PSMD11,PSMD12,PSMD14,PSMD2,PSMD7,PSME2,PSME3,SEL1L,VCP"]
["RhoGDI Signaling",4.95,0.107,0.943,"ACTA1,ACTR3,ARHGAP1,ARHGAP8/PRR5-ARHGAP8,ARHGEF12,ARHGEF5,ARPC5,ARPC5L,CDH1,CDH11,CDH3,GNA15,GNB1L,GNG10,ITGA5,ITGA7,ITGAX,ITGB1,MYL9,PAK1,PAK4,PPP1R12B,WASF2","Leukocyte Extravasation Signaling",1.53,0.0363,-1.89,"ARHGAP6,GNAI3,ITGA2,MAP2K2,MAP3K4,PTK2B,RDX","Superpathway of Geranylgeranyldiphosphate Biosynthesis I (via Mevalonate)",3.95,0.278,-1.342,"ACAT1,ACAT2,HMGCS1,MVD,MVK","Superpathway of Geranylgeranyldiphosphate Biosynthesis I (via Mevalonate)",3.95,0.278,-1.342,"ACAT1,ACAT2,HMGCS1,MVD,MVK","Microautophagy Signaling Pathway",8.51,0.188,5.014,"BAG6,COL15A1,LAMP2,PRKAG2,PSMA2,PSMA5,PSMA6,PSMB1,PSMB3,PSMB5,PSMB6,PSMC1,PSMC2,PSMC4,PSMC6,PSMD11,PSMD12,PSMD14,PSMD2,PSMD7,PSME2,PSME3,RHOT2,SEC13,SEC23B,SEC24B,SEC24C,SEC24D,SEC31A,VPS36"]
["Sperm Motility",1.68,0.0669,0.816,"ABL2,EGFR,ERBB2,FRK,GNA15,GNB1L,GNG10,IGF1R,ITPR2,MAP2K6,PDGFRB,PLCB4,PRDX6,PRKACB,PRKG2,TNK1,TWF1","IL-8 Signaling",1.35,0.0332,-1.89,"CSTB,GNAI3,KRAS,MAP2K2,MAP4K4,NRAS,PTK2B","NRF2-mediated Oxidative Stress Response",2.92,0.0675,-1.414,"AOX1,CLPP,DNAJB2,DNAJC10,GCLC,GSR,GSTA2,GSTM2,GSTM3,GSTP1,HSP90AB1,MGST3,PRKCD,RALB,RRAS2,TXNRD1","NRF2-mediated Oxidative Stress Response",2.92,0.0675,-1.414,"AOX1,CLPP,DNAJB2,DNAJC10,GCLC,GSR,GSTA2,GSTM2,GSTM3,GSTP1,HSP90AB1,MGST3,PRKCD,RALB,RRAS2,TXNRD1","Signaling by the B Cell Receptor (BCR)",7.87,0.176,5.014,"BCL10,FKBP1A,ITPR1,LYN,MALT1,PIK3R1,PPIA,PPP3R1,PSMA2,PSMA5,PSMA6,PSMB1,PSMB3,PSMB5,PSMB6,PSMC1,PSMC2,PSMC4,PSMC6,PSMD11,PSMD12,PSMD14,PSMD2,PSMD7,PSME2,PSME3,PTPN6,SH3KBP1,SYK,VAV1"]
["ILK Signaling",4.03,0.101,0.728,"ACTA1,CDH1,CREB1,FERMT2,FLNA,FLNC,ILK,ITGB1,LIMS1,LIMS2,MAP2K6,MAPK3,MYL9,MYO5C,NFKB2,PARVA,RPS6KA4,RSU1,TGFB1I1,VCL","Integrin Signaling",1.33,0.0329,-1.89,"ARF6,ARPC1A,ARPC3,ITGA2,KRAS,MAP2K2,NRAS","3-phosphoinositide Biosynthesis",2.28,0.064,-1.508,"ATP1A1,EPHX2,INPPL1,NT5C,NUDT12,NUDT9,PDXP,PI4KA,PIP4K2C,PPP1R14B,PPP1R3D,PPP2R5A,SACM1L","3-phosphoinositide Biosynthesis",2.28,0.064,-1.508,"ATP1A1,EPHX2,INPPL1,NT5C,NUDT12,NUDT9,PDXP,PI4KA,PIP4K2C,PPP1R14B,PPP1R3D,PPP2R5A,SACM1L","TCR signaling",7.72,0.198,5,"BCL10,CSK,EVL,HLA-DRB1,MALT1,PAK2,PIK3R1,PSMA2,PSMA5,PSMA6,PSMB1,PSMB3,PSMB5,PSMB6,PSMC1,PSMC2,PSMC4,PSMC6,PSMD11,PSMD12,PSMD14,PSMD2,PSMD7,PSME2,PSME3"]
["Complement System",9.21,0.351,0.707,"C1QBP,C1QC,C2,C3,C4A/C4B,C5,C7,C8A,C8B,C9,CFI,ITGAX,SERPING1","Autophagy",1.33,0.0329,-1.89,"ATG12,ATG5,DAPK1,GNAI3,MAP2K2,PPP2CB,VAMP8","Xenobiotic Metabolism CAR Signaling Pathway",3,0.0741,-1.604,"ALDH18A1,ALDH1B1,ALDH1L1,ALDH3A2,ALDH9A1,GSTA2,GSTM2,GSTM3,GSTP1,HSP90AB1,MGST3,PPP2R5A,PRKCD,SULT2B1","Xenobiotic Metabolism CAR Signaling Pathway",3,0.0741,-1.604,"ALDH18A1,ALDH1B1,ALDH1L1,ALDH3A2,ALDH9A1,GSTA2,GSTM2,GSTM3,GSTP1,HSP90AB1,MGST3,PPP2R5A,PRKCD,SULT2B1","Transcriptional regulation by RUNX1",6.63,0.171,5,"ACTL6A,ARID1A,ARID1B,CBFB,H2AC20,PBRM1,PSMA2,PSMA5,PSMA6,PSMB1,PSMB3,PSMB5,PSMB6,PSMC1,PSMC2,PSMC4,PSMC6,PSMD11,PSMD12,PSMD14,PSMD2,PSMD7,PSME2,PSME3,SMARCB1,SMARCD2"]
["PAK Signaling",1.78,0.0847,0.707,"ITGA5,ITGA7,ITGAX,ITGB1,MAPK3,MYL9,PAK1,PAK1IP1,PAK4,PDGFRB","Actin Cytoskeleton Signaling",2.83,0.0449,-1.897,"ARPC1A,ARPC3,BAIAP2,IQGAP2,ITGA2,KRAS,MAP2K2,MYO10,NRAS,RDX,TMSB10/TMSB4X","CDK5 Signaling",3.48,0.0982,-1.633,"CAPN1,ITGA3,ITGA6,LAMA3,LAMB3,LAMC2,PPP1R14B,PPP1R3D,PPP2R5A,RALB,RRAS2","CDK5 Signaling",3.48,0.0982,-1.633,"CAPN1,ITGA3,ITGA6,LAMA3,LAMB3,LAMC2,PPP1R14B,PPP1R3D,PPP2R5A,RALB,RRAS2","Mitotic Metaphase and Anaphase",5.68,0.136,4.95,"BUB3,DYNC1I1,LMNB1,NDE1,NUP58,NUP98,PSMA2,PSMA5,PSMA6,PSMB1,PSMB3,PSMB5,PSMB6,PSMC1,PSMC2,PSMC4,PSMC6,PSMD11,PSMD12,PSMD14,PSMD2,PSMD7,PSME2,PSME3,RAN,RANBP2,RCC1,RCC2,SEC13,SUMO1,TUBB1,UBE2E1"]
["PI3K/AKT Signaling",1.33,0.0653,0.707,"EIF4EBP1,GDF15,ILK,ITGA5,ITGA7,ITGAX,ITGB1,LIMS1,MAP3K5,MAPK3,NFKB2,OCRL,SYNJ2","Oncostatin M Signaling",2.38,0.093,-2,"KRAS,MAP2K2,NRAS,STAT3","P2Y Purigenic Receptor Signaling Pathway",1.52,0.062,-1.633,"GNAI2,GNG12,GNG4,PLCD1,PLCH2,PRKCD,RALB,RRAS2","P2Y Purigenic Receptor Signaling Pathway",1.52,0.062,-1.633,"GNAI2,GNG12,GNG4,PLCD1,PLCH2,PRKCD,RALB,RRAS2","Fc epsilon receptor (FCERI) signaling",5.5,0.141,4.914,"BCL10,ITPR1,LYN,MALT1,PAK2,PIK3R1,PPP3R1,PSMA2,PSMA5,PSMA6,PSMB1,PSMB3,PSMB5,PSMB6,PSMC1,PSMC2,PSMC4,PSMC6,PSMD11,PSMD12,PSMD14,PSMD2,PSMD7,PSME2,PSME3,SHC1,SYK,VAV1,VAV2"]
["Integrin Signaling",3.6,0.0939,0.688,"ACTA1,ACTR3,ARPC5,ARPC5L,CAPNS1,ILK,ITGA5,ITGA7,ITGAX,ITGB1,LIMS1,MAPK3,MYL9,PAK1,PAK4,PARVA,PFN2,PPP1R12B,TLN1,VCL","CD27 Signaling in Lymphocytes",1.95,0.0702,-2,"CYCS,MAP2K2,MAP3K4,MAP3K6","GP6 Signaling Pathway",2,0.0709,-1.667,"ADAM10,COL12A1,COL17A1,COL4A6,COL7A1,LAMA3,LAMB3,LAMC2,PRKCD","GP6 Signaling Pathway",2,0.0709,-1.667,"ADAM10,COL12A1,COL17A1,COL4A6,COL7A1,LAMA3,LAMB3,LAMC2,PRKCD","Mitochondrial translation",9.57,0.25,4.899,"GADD45GIP1,GFM1,MRPL11,MRPL15,MRPL19,MRPL20,MRPL28,MRPL3,MRPL37,MRPL38,MRPL39,MRPL43,MRPL44,MRPL46,MRPL49,MRPS16,MRPS23,MRPS26,MRPS28,MRPS34,MRPS9,MTIF2,PTCD3,TUFM"]
["HER-2 Signaling in Breast Cancer",1.68,0.0714,0.535,"COX6B1,COX7A2L,EGF,EGFR,ELF1,ERBB2,FRK,GNB1L,ITGB1,KPNB1,MAPK3,MLST8,NFKB2,RB1","IL-2 Signaling",1.84,0.0656,-2,"KRAS,MAP2K2,NRAS,PTK2B","ERK/MAPK Signaling",1.72,0.0561,-1.667,"DOCK1,HSPB1,ITGA1,ITGA3,ITGA6,ITGB4,PPP1R14B,PPP1R3D,PPP2R5A,PRKCD,RALB,RRAS2","ERK/MAPK Signaling",1.72,0.0561,-1.667,"DOCK1,HSPB1,ITGA1,ITGA3,ITGA6,ITGB4,PPP1R14B,PPP1R3D,PPP2R5A,PRKCD,RALB,RRAS2","PTEN Regulation",7.94,0.187,4.899,"CHD4,GATAD2B,LAMTOR3,MLST8,MTA2,PML,PSMA2,PSMA5,PSMA6,PSMB1,PSMB3,PSMB5,PSMB6,PSMC1,PSMC2,PSMC4,PSMC6,PSMD11,PSMD12,PSMD14,PSMD2,PSMD7,PSME2,PSME3,RBBP4,RHEB,USP13,USP7"]
["Myc Mediated Apoptosis Signaling",1.36,0.1,0.447,"BAX,CASP8,MAX,NFKB2,PRKACB","Thrombopoietin Signaling",1.8,0.0635,-2,"KRAS,MAP2K2,NRAS,STAT3","D-myo-inositol-5-phosphate Metabolism",2.91,0.0725,-1.732,"ATP1A1,EPHX2,INPPL1,NT5C,NUDT12,NUDT9,PDXP,PIP4K2C,PLCD1,PLCH2,PPP1R14B,PPP1R3D,PPP2R5A,SACM1L","D-myo-inositol-5-phosphate Metabolism",2.91,0.0725,-1.732,"ATP1A1,EPHX2,INPPL1,NT5C,NUDT12,NUDT9,PDXP,PIP4K2C,PLCD1,PLCH2,PPP1R14B,PPP1R3D,PPP2R5A,SACM1L","Hedgehog ligand biogenesis",12.7,0.354,4.796,"ERLEC1,OS9,P4HB,PSMA2,PSMA5,PSMA6,PSMB1,PSMB3,PSMB5,PSMB6,PSMC1,PSMC2,PSMC4,PSMC6,PSMD11,PSMD12,PSMD14,PSMD2,PSMD7,PSME2,PSME3,SEL1L,VCP"]
["TNFR1 Signaling",1.3,0.0962,0.447,"BIRC2,CASP8,NFKB2,PAK1,PAK4","ErbB2-ErbB3 Signaling",1.75,0.0615,-2,"KRAS,MAP2K2,NRAS,STAT3","Superpathway of Inositol Phosphate Compounds",3,0.0687,-1.807,"ATP1A1,EPHX2,INPP5A,INPPL1,NT5C,NUDT12,NUDT9,PDXP,PI4KA,PIP4K2C,PLCD1,PLCH2,PPP1R14B,PPP1R3D,PPP2R5A,SACM1L","Superpathway of Inositol Phosphate Compounds",3,0.0687,-1.807,"ATP1A1,EPHX2,INPP5A,INPPL1,NT5C,NUDT12,NUDT9,PDXP,PI4KA,PIP4K2C,PLCD1,PLCH2,PPP1R14B,PPP1R3D,PPP2R5A,SACM1L","Synthesis of DNA",6.93,0.193,4.796,"CDK2,FEN1,MCM3,PCNA,PSMA2,PSMA5,PSMA6,PSMB1,PSMB3,PSMB5,PSMB6,PSMC1,PSMC2,PSMC4,PSMC6,PSMD11,PSMD12,PSMD14,PSMD2,PSMD7,PSME2,PSME3,UBE2E1"]
["LXR/RXR Activation",2.52,0.0976,0.333,"APOE,ARG2,C3,C4A/C4B,C9,CYP51A1,FASN,LYZ,NCOR2,NFKB2,RXRA,SERPINF1","SPINK1 General Cancer Pathway",1.67,0.058,-2,"KRAS,MAP2K2,NRAS,STAT3","Regulation of Cellular Mechanics by Calpain Protease",4.38,0.124,-1.89,"ACTN4,CAPN1,CAPN5,CAST,CDK1,ITGA1,ITGA3,ITGA6,ITGB4,RALB,RRAS2","Regulation of Cellular Mechanics by Calpain Protease",4.38,0.124,-1.89,"ACTN4,CAPN1,CAPN5,CAST,CDK1,ITGA1,ITGA3,ITGA6,ITGB4,RALB,RRAS2","Superpathway of Inositol Phosphate Compounds",2.88,0.106,4.796,"ATP1A2,DUSP23,IGBP1,ILKAP,INPPL1,MTMR2,NUDT2,NUDT4,NUDT5,NUDT9,PGAM5,PI4K2A,PIK3R1,PIP4K2C,PPP1CA,PPP1R14B,PPP1R8,PPP3R1,PTPN1,PTPN12,PTPN6,PTPRF,SET,THTPA,WBP11"]
["3-phosphoinositide Degradation",1.8,0.0741,0.277,"ACP5,HACD2,ITPK1,MINPP1,OCRL,PAWR,PPFIBP2,PPP1CA,PPP1R12B,PPP1R13B,PTPN13,SSH3,SYNJ2,TNS3","GM-CSF Signaling",1.65,0.0571,-2,"KRAS,MAP2K2,NRAS,STAT3","p70S6K Signaling",1.47,0.0606,-1.89,"GNAI2,PLCD1,PLCH2,PPP2R5A,PRKCD,RALB,RRAS2,SFN","p70S6K Signaling",1.47,0.0606,-1.89,"GNAI2,PLCD1,PLCH2,PPP2R5A,PRKCD,RALB,RRAS2,SFN","Transcriptional regulation by RUNX3",8.07,0.229,4.69,"CBFB,CTNNB1,PSMA2,PSMA5,PSMA6,PSMB1,PSMB3,PSMB5,PSMB6,PSMC1,PSMC2,PSMC4,PSMC6,PSMD11,PSMD12,PSMD14,PSMD2,PSMD7,PSME2,PSME3,TEAD3,TGFB1"]
["D-myo-inositol-5-phosphate Metabolism",1.73,0.0725,0.277,"ACP5,HACD2,ITPK1,MINPP1,OCRL,PAWR,PLCB4,PPFIBP2,PPP1CA,PPP1R12B,PPP1R13B,PTPN13,SSH3,TNS3","Neurotrophin/TRK Signaling",1.53,0.0526,-2,"KLK3,KRAS,MAP2K2,NRAS","Xenobiotic Metabolism PXR Signaling Pathway",3.93,0.0833,-2,"ALDH18A1,ALDH1B1,ALDH1L1,ALDH3A2,ALDH9A1,ESD,GSTA2,GSTM2,GSTM3,GSTP1,HSP90AB1,MGST3,PPP1R14B,PPP1R3D,PRKCD,SULT2B1","Xenobiotic Metabolism PXR Signaling Pathway",3.93,0.0833,-2,"ALDH18A1,ALDH1B1,ALDH1L1,ALDH3A2,ALDH9A1,ESD,GSTA2,GSTM2,GSTM3,GSTP1,HSP90AB1,MGST3,PPP1R14B,PPP1R3D,PRKCD,SULT2B1","Mitotic G1 phase and G1/S transition",6.15,0.176,4.69,"CDK2,CDKN1B,LYN,PCNA,PSMA2,PSMA5,PSMA6,PSMB1,PSMB3,PSMB5,PSMB6,PSMC1,PSMC2,PSMC4,PSMC6,PSMD11,PSMD12,PSMD14,PSMD2,PSMD7,PSME2,PSME3,RBBP4"]
["Superpathway of Inositol Phosphate Compounds",1.7,0.0687,0.258,"ACP5,CDIPT,HACD2,ITPK1,MINPP1,OCRL,PAWR,PLCB4,PPFIBP2,PPP1CA,PPP1R12B,PPP1R13B,PTPN13,SSH3,SYNJ2,TNS3","Macropinocytosis Signaling",1.53,0.0526,-2,"ABI1,ARF6,KRAS,NRAS","Cholesterol Biosynthesis I",3.44,0.308,-2,"DHCR7,FDFT1,LSS,TM7SF2","Cholesterol Biosynthesis I",3.44,0.308,-2,"DHCR7,FDFT1,LSS,TM7SF2","Interleukin-1 family signaling",5.69,0.171,4.69,"CASP1,PSMA2,PSMA5,PSMA6,PSMB1,PSMB3,PSMB5,PSMB6,PSMC1,PSMC2,PSMC4,PSMC6,PSMD11,PSMD12,PSMD14,PSMD2,PSMD7,PSME2,PSME3,PTPN12,PTPN6,TOLLIP"]
["Actin Cytoskeleton Signaling",4.96,0.102,-0.229,"ACTA1,ACTR3,ARHGEF12,ARPC5,ARPC5L,CYFIP2,EGF,F2,FLNA,ITGA5,ITGA7,ITGAX,ITGB1,MAPK3,MYL9,MYO5C,PAK1,PAK4,PFN2,PPP1R12B,SSH3,TLN1,VAV2,VCL,WASF2","IL-15 Signaling",1.51,0.0519,-2,"KRAS,MAP2K2,NRAS,STAT3","Cholesterol Biosynthesis II (via 24,25-dihydrolanosterol)",3.44,0.308,-2,"DHCR7,FDFT1,LSS,TM7SF2","Cholesterol Biosynthesis II (via 24,25-dihydrolanosterol)",3.44,0.308,-2,"DHCR7,FDFT1,LSS,TM7SF2","3-phosphoinositide Biosynthesis",3.69,0.12,4.69,"ATP1A2,DUSP23,IGBP1,ILKAP,INPPL1,MTMR2,NUDT2,NUDT4,NUDT5,NUDT9,PGAM5,PI4K2A,PIK3R1,PIP4K2C,PPP1CA,PPP1R14B,PPP1R8,PPP3R1,PTPN1,PTPN12,PTPN6,PTPRF,SET,THTPA,WBP11"]
["Adrenomedullin signaling pathway",1.63,0.0704,-0.277,"BAX,C3,GNA15,ITPR2,MAP2K6,MAPK13,MAPK3,MAX,NFKB2,PLCB4,PRKACB,PRKG2,RXRA,SLC39A7","IL-3 Signaling",1.48,0.0506,-2,"KRAS,MAP2K2,NRAS,STAT3","Cholesterol Biosynthesis III (via Desmosterol)",3.44,0.308,-2,"DHCR7,FDFT1,LSS,TM7SF2","Cholesterol Biosynthesis III (via Desmosterol)",3.44,0.308,-2,"DHCR7,FDFT1,LSS,TM7SF2","COPI-mediated anterograde transport",13,0.284,4.642,"ARCN1,ARF4,ARF5,ARFGAP2,ARFGAP3,COG1,COG2,COG3,COG5,COG6,COG8,COPA,COPB1,COPB2,COPE,COPG1,DYNC1I1,GBF1,GOLGA2,GOLGB1,GOSR1,NSF,SPTBN2,STX5,TMED10,TMEM115,TUBB1,USO1,YKT6"]
["3-phosphoinositide Biosynthesis",1.57,0.069,-0.277,"ACP5,CDIPT,HACD2,ITPK1,MINPP1,OCRL,PAWR,PPFIBP2,PPP1CA,PPP1R12B,PPP1R13B,PTPN13,SSH3,TNS3","Thyroid Cancer Signaling",1.48,0.0506,-2,"KLK3,KRAS,MAP2K2,NRAS","Glutathione Redox Reactions I",2.3,0.16,-2,"GSR,GSTM2,GSTP1,MGST3","Glutathione Redox Reactions I",2.3,0.16,-2,"GSR,GSTM2,GSTP1,MGST3","Mitotic G2-G2/M phases",4,0.126,4.6,"CDK2,CSNK1D,HSP90AA1,HSP90AB1,NDE1,PSMA2,PSMA5,PSMA6,PSMB1,PSMB3,PSMB5,PSMB6,PSMC1,PSMC2,PSMC4,PSMC6,PSMD11,PSMD12,PSMD14,PSMD2,PSMD7,PSME2,PSME3,RBBP4,TUBB1"]
["Regulation of Cellular Mechanics by Calpain Protease",3.19,0.124,-0.378,"CAPNS1,EGF,EGFR,ITGA5,ITGA7,ITGAX,ITGB1,MAPK3,RB1,TLN1,VCL","FLT3 Signaling in Hematopoietic Progenitor Cells",1.46,0.05,-2,"KRAS,MAP2K2,NRAS,STAT3","D-myo-inositol (1,4,5)-Trisphosphate Biosynthesis",2.24,0.154,-2,"PI4KA,PIP4K2C,PLCD1,PLCH2","D-myo-inositol (1,4,5)-Trisphosphate Biosynthesis",2.24,0.154,-2,"PI4KA,PIP4K2C,PLCD1,PLCH2","Regulation of mitotic cell cycle",8.07,0.239,4.583,"BUB3,CDK2,PSMA2,PSMA5,PSMA6,PSMB1,PSMB3,PSMB5,PSMB6,PSMC1,PSMC2,PSMC4,PSMC6,PSMD11,PSMD12,PSMD14,PSMD2,PSMD7,PSME2,PSME3,UBE2E1"]
["fMLP Signaling in Neutrophils",1.5,0.0763,-0.378,"ACTR3,ARPC5,ARPC5L,GNA15,GNB1L,GNG10,ITPR2,MAPK3,NFKB2,PLCB4","JAK/Stat Signaling",1.43,0.0488,-2,"KRAS,MAP2K2,NRAS,STAT3","Xenobiotic Metabolism AHR Signaling Pathway",4.48,0.126,-2.111,"ALDH18A1,ALDH1B1,ALDH1L1,ALDH3A2,ALDH9A1,GSTA2,GSTM2,GSTM3,GSTP1,HSP90AB1,MGST3","Xenobiotic Metabolism AHR Signaling Pathway",4.48,0.126,-2.111,"ALDH18A1,ALDH1B1,ALDH1L1,ALDH3A2,ALDH9A1,GSTA2,GSTM2,GSTM3,GSTP1,HSP90AB1,MGST3","KEAP1-NFE2L2 pathway",7.79,0.231,4.583,"DPP3,PSMA2,PSMA5,PSMA6,PSMB1,PSMB3,PSMB5,PSMB6,PSMC1,PSMC2,PSMC4,PSMC6,PSMD11,PSMD12,PSMD14,PSMD2,PSMD7,PSME2,PSME3,UFD1,VCP"]
["Endocannabinoid Developing Neuron Pathway",1.3,0.0732,-0.378,"CREB1,GNB1L,GNG10,MAP2K6,MAPK13,MAPK3,MLST8,PRKACB,RAP1GAP","Renin-Angiotensin Signaling",1.42,0.0417,-2,"KRAS,MAP2K2,NRAS,PTK2B,STAT3","Synaptic Long Term Potentiation",1.52,0.062,-2.121,"CHP1,PLCD1,PLCH2,PPP1R14B,PPP1R3D,PRKCD,RALB,RRAS2","Synaptic Long Term Potentiation",1.52,0.062,-2.121,"CHP1,PLCD1,PLCH2,PPP1R14B,PPP1R3D,PRKCD,RALB,RRAS2","DNA Replication Pre-Initiation",6.72,0.202,4.583,"H2AC20,MCM3,PSMA2,PSMA5,PSMA6,PSMB1,PSMB3,PSMB5,PSMB6,PSMC1,PSMC2,PSMC4,PSMC6,PSMD11,PSMD12,PSMD14,PSMD2,PSMD7,PSME2,PSME3,UBE2E1"]
["Acetone Degradation I (to Methylglyoxal)",2.14,0.156,-0.447,"CYP4X1,CYP51A1,DHRS11,POR,ZADH2","Prolactin Signaling",1.36,0.0465,-2,"KRAS,MAP2K2,NRAS,STAT3","Glutathione-mediated Detoxification",2.66,0.152,-2.236,"GSTA2,GSTM2,GSTM3,GSTP1,MGST3","Glutathione-mediated Detoxification",2.66,0.152,-2.236,"GSTA2,GSTM2,GSTM3,GSTP1,MGST3","3-phosphoinositide Degradation",3.4,0.119,4.583,"ATP1A2,DUSP23,IGBP1,ILKAP,INPP4A,INPPL1,MTMR2,NUDT2,NUDT4,NUDT5,NUDT9,PGAM5,PPP1CA,PPP1R14B,PPP1R8,PPP3R1,PTPN1,PTPN12,PTPN6,PTPRF,SET,THTPA,WBP11"]
["EIF2 Signaling",1.85,0.0714,-0.447,"ACTA1,EIF2B3,EIF2B4,EIF3A,EIF3B,EIF3D,EIF3E,EIF3G,EIF3H,EIF3I,EIF3K,EIF3L,EIF4A1,IGF1R,MAPK3,PPP1CA","PDGF Signaling",1.36,0.0465,-2,"KRAS,MAP2K2,NRAS,STAT3","Actin Nucleation by ARP-WASP Complex",2.32,0.086,-2.236,"ARPC4,ITGA1,ITGA3,ITGA6,ITGB4,RALB,ROCK1,RRAS2","Actin Nucleation by ARP-WASP Complex",2.32,0.086,-2.236,"ARPC4,ITGA1,ITGA3,ITGA6,ITGB4,RALB,ROCK1,RRAS2","RAF/MAP kinase cascade",3.21,0.107,4.536,"CAMK2G,CSK,DLG1,LAMTOR3,NCAM1,PIK3R1,PSMA2,PSMA5,PSMA6,PSMB1,PSMB3,PSMB5,PSMB6,PSMC1,PSMC2,PSMC4,PSMC6,PSMD11,PSMD12,PSMD14,PSMD2,PSMD7,PSME2,PSME3,RANBP9,RASA3,SHC1,SPTBN2"]
["CD27 Signaling in Lymphocytes",1.65,0.105,-0.447,"CASP8,CYC1,MAP2K6,MAP3K3,MAP3K5,NFKB2","BMP signaling pathway",1.35,0.046,-2,"KRAS,MAP2K2,NRAS,TAB1","Paxillin Signaling",1.94,0.0741,-2.236,"ACTN4,DOCK1,ITGA1,ITGA3,ITGA6,ITGB4,RALB,RRAS2","Paxillin Signaling",1.94,0.0741,-2.236,"ACTN4,DOCK1,ITGA1,ITGA3,ITGA6,ITGB4,RALB,RRAS2","Metabolism of polyamines",10.7,0.339,4.472,"PSMA2,PSMA5,PSMA6,PSMB1,PSMB3,PSMB5,PSMB6,PSMC1,PSMC2,PSMC4,PSMC6,PSMD11,PSMD12,PSMD14,PSMD2,PSMD7,PSME2,PSME3,SMS,SRM"]
["Dilated Cardiomyopathy Signaling Pathway",2.78,0.0959,-0.577,"ACTA1,BAX,CAMK2D,CNN1,DES,ILK,ITPR2,MAP3K3,MAPK13,MAPK3,MYL9,MYO5C,PRKACB,SGCD","NRF2-mediated Oxidative Stress Response",2.43,0.0422,-2.121,"CAT,CBR1,DNAJA4,ERP29,FTL,JUND,KRAS,MAP2K2,NRAS,SOD2","Regulation of Actin-based Motility by Rho",1.77,0.069,-2.236,"ARPC4,ITGA1,ITGA3,ITGA6,ITGB4,PI4KA,PIP4K2C,ROCK1","Regulation of Actin-based Motility by Rho",1.77,0.069,-2.236,"ARPC4,ITGA1,ITGA3,ITGA6,ITGB4,PI4KA,PIP4K2C,ROCK1","COPII-mediated vesicle transport",8.96,0.278,4.472,"CSNK1D,CTSZ,GOLGA2,LMAN1,NSF,PPP6R1,SCFD1,SEC13,SEC16A,SEC23B,SEC23IP,SEC24B,SEC24C,SEC24D,SEC31A,STX5,TMED10,TRAPPC3,USO1,YKT6"]
["PTEN Signaling",2.67,0.0933,-0.577,"EGFR,IGF1R,IGF2R,ILK,ITGA5,ITGA7,ITGAX,ITGB1,MAPK3,MAST2,NFKB2,OCRL,PDGFRB,SYNJ2","CNTF Signaling",2.75,0.0877,-2.236,"KRAS,LIFR,MAP2K2,NRAS,STAT3","HGF Signaling",1.47,0.0606,-2.236,"DOCK1,ITGA1,ITGA3,ITGA6,ITGB4,PRKCD,RALB,RRAS2","HGF Signaling",1.47,0.0606,-2.236,"DOCK1,ITGA1,ITGA3,ITGA6,ITGB4,PRKCD,RALB,RRAS2","Regulation of RUNX2 expression and activity",8.84,0.274,4.472,"CBFB,PSMA2,PSMA5,PSMA6,PSMB1,PSMB3,PSMB5,PSMB6,PSMC1,PSMC2,PSMC4,PSMC6,PSMD11,PSMD12,PSMD14,PSMD2,PSMD7,PSME2,PSME3,STAT1"]
["Thrombin Signaling",2.46,0.081,-0.577,"ARHGEF12,ARHGEF5,CAMK2D,CREB1,EGF,EGFR,F2,GNA15,GNB1L,GNG10,ITPR2,MAPK13,MAPK3,MYL9,NFKB2,PLCB4,PPP1R12B","Chemokine Signaling",2.11,0.0625,-2.236,"GNAI3,KRAS,MAP2K2,NRAS,PTK2B","Leukocyte Extravasation Signaling",2.47,0.0674,-2.309,"ACTN4,AFDN,CLDN4,CTNNA1,CTNNA2,CTNNB1,CTNND1,F11R,GNAI2,ITGA3,PRKCD,ROCK1,TIMP1","Leukocyte Extravasation Signaling",2.47,0.0674,-2.309,"ACTN4,AFDN,CLDN4,CTNNA1,CTNNA2,CTNNB1,CTNND1,F11R,GNAI2,ITGA3,PRKCD,ROCK1,TIMP1","trans-Golgi Network Vesicle Budding",8.73,0.27,4.472,"ACBD3,AP1G1,AP1M2,AP1S2,CLINT1,CLTA,CPD,CTSZ,DNASE2,GAK,GBF1,GNS,GOLGB1,HIP1R,IGF2R,M6PR,NECAP1,SH3D19,SNAPIN,TPD52"]
["Apoptosis Signaling",2.63,0.106,-0.632,"BAX,BIRC2,BIRC6,CAPNS1,CASP8,CYC1,ENDOG,MAP3K5,MAPK3,NFKB2,SPTAN1","α-Adrenergic Signaling",1.63,0.0472,-2.236,"GNAI3,KRAS,MAP2K2,NRAS,PYGB","Actin Cytoskeleton Signaling",2.37,0.0612,-2.309,"ACTN4,ARPC4,DIAPH1,DOCK1,GNG12,IQGAP1,ITGA1,ITGA3,ITGA6,ITGB4,MYH14,RALB,ROCK1,RRAS2,SLC9A1","Actin Cytoskeleton Signaling",2.37,0.0612,-2.309,"ACTN4,ARPC4,DIAPH1,DOCK1,GNG12,IQGAP1,ITGA1,ITGA3,ITGA6,ITGB4,MYH14,RALB,ROCK1,RRAS2,SLC9A1","Degradation of beta-catenin by the destruction complex",6.99,0.217,4.472,"CTBP2,CTNNB1,PSMA2,PSMA5,PSMA6,PSMB1,PSMB3,PSMB5,PSMB6,PSMC1,PSMC2,PSMC4,PSMC6,PSMD11,PSMD12,PSMD14,PSMD2,PSMD7,PSME2,PSME3"]
["Rac Signaling",2.12,0.087,-0.632,"ACTR3,ARPC5,ARPC5L,CYFIP2,ITGA5,ITGA7,ITGAX,ITGB1,MAPK3,NFKB2,PAK1,PAK4","Paxillin Signaling",1.6,0.0463,-2.236,"ARF6,ITGA2,KRAS,NRAS,PTK2B","Superpathway of Cholesterol Biosynthesis",7.19,0.31,-2.333,"ACAT1,ACAT2,DHCR7,FDFT1,HMGCS1,LSS,MVD,MVK,TM7SF2","Superpathway of Cholesterol Biosynthesis",7.19,0.31,-2.333,"ACAT1,ACAT2,DHCR7,FDFT1,HMGCS1,LSS,MVD,MVK,TM7SF2","D-myo-inositol-5-phosphate Metabolism",3.24,0.116,4.472,"ATP1A2,DUSP23,IGBP1,ILKAP,INPPL1,MTMR2,NUDT2,NUDT4,NUDT5,NUDT9,PGAM5,PIP4K2C,PPP1CA,PPP1R14B,PPP1R8,PPP3R1,PTPN1,PTPN12,PTPN6,PTPRF,SET,THTPA,WBP11"]
["Agrin Interactions at Neuromuscular Junction",4.13,0.157,-0.707,"ACTA1,AGRN,EGFR,ERBB2,ITGB1,LAMA2,LAMB1,LAMC1,MAPK3,PAK1,PAK4","MSP-RON Signaling In Macrophages Pathway",1.46,0.0427,-2.236,"KLK2,KLK3,KRAS,NRAS,STAT3","Aldosterone Signaling in Epithelial Cells",4.17,0.0915,-2.449,"CRYAB,DNAJB2,DNAJC10,DNAJC25,HSP90AB1,HSPA4L,HSPB1,HSPD1,PI4KA,PIP4K2C,PLCD1,PLCH2,PRKCD,SLC9A1,TRAP1","Aldosterone Signaling in Epithelial Cells",4.17,0.0915,-2.449,"CRYAB,DNAJB2,DNAJC10,DNAJC25,HSP90AB1,HSPA4L,HSPB1,HSPD1,PI4KA,PIP4K2C,PLCD1,PLCH2,PRKCD,SLC9A1,TRAP1","TCF dependent signaling in response to WNT",3.21,0.116,4.379,"CAV1,CTNNB1,H2AC20,MEN1,PSMA2,PSMA5,PSMA6,PSMB1,PSMB3,PSMB5,PSMB6,PSMC1,PSMC2,PSMC4,PSMC6,PSMD11,PSMD12,PSMD14,PSMD2,PSMD7,PSME2,PSME3,TRRAP"]
["Salvage Pathways of Pyrimidine Ribonucleotides",1.44,0.0816,-0.707,"CDK7,CMPK1,CSNK1D,IRAK1,MAP2K6,MAPK3,PAK1,UCK1","PAK Signaling",1.45,0.0424,-2.236,"ITGA2,KRAS,MAP2K2,NRAS,PTK2B","14-3-3-mediated Signaling",2.49,0.0787,-2.449,"PLCD1,PLCH2,PRKCD,RALB,RRAS2,SFN,TUBA4A,TUBB,TUBB2A,TUBG1","14-3-3-mediated Signaling",2.49,0.0787,-2.449,"PLCD1,PLCH2,PRKCD,RALB,RRAS2,SFN,TUBA4A,TUBB,TUBB2A,TUBG1","Regulation of Apoptosis",10.7,0.358,4.359,"PAK2,PSMA2,PSMA5,PSMA6,PSMB1,PSMB3,PSMB5,PSMB6,PSMC1,PSMC2,PSMC4,PSMC6,PSMD11,PSMD12,PSMD14,PSMD2,PSMD7,PSME2,PSME3"]
["Estrogen Biosynthesis",2.17,0.136,-0.816,"AKR1C3,CYP4X1,CYP51A1,DHRS11,HSD17B12,POR","NGF Signaling",1.45,0.0424,-2.236,"KRAS,MAP2K2,MAP3K4,MAP3K6,NRAS","fMLP Signaling in Neutrophils",1.49,0.0611,-2.449,"ARPC4,CHP1,GNAI2,GNG12,GNG4,PRKCD,RALB,RRAS2","fMLP Signaling in Neutrophils",1.49,0.0611,-2.449,"ARPC4,CHP1,GNAI2,GNG12,GNG4,PRKCD,RALB,RRAS2","NIK-->noncanonical NF-kB signaling",9.62,0.317,4.359,"NFKB2,PSMA2,PSMA5,PSMA6,PSMB1,PSMB3,PSMB5,PSMB6,PSMC1,PSMC2,PSMC4,PSMC6,PSMD11,PSMD12,PSMD14,PSMD2,PSMD7,PSME2,PSME3"]
["PFKFB4 Signaling Pathway",2.08,0.13,-0.816,"CREB1,FBP1,HK1,MAP2K6,MAPK3,PRKACB","Role of NANOG in Mammalian Embryonic Stem Cell Pluripotency",1.42,0.0417,-2.236,"KRAS,LIFR,MAP2K2,NRAS,STAT3","Rac Signaling",2.23,0.0725,-2.646,"ARPC4,IQGAP1,ITGA1,ITGA3,ITGA6,ITGB4,PI4KA,PIP4K2C,RALB,RRAS2","Rac Signaling",2.23,0.0725,-2.646,"ARPC4,IQGAP1,ITGA1,ITGA3,ITGA6,ITGB4,PI4KA,PIP4K2C,RALB,RRAS2","Cellular response to hypoxia",7.82,0.253,4.359,"ELOC,PSMA2,PSMA5,PSMA6,PSMB1,PSMB3,PSMB5,PSMB6,PSMC1,PSMC2,PSMC4,PSMC6,PSMD11,PSMD12,PSMD14,PSMD2,PSMD7,PSME2,PSME3"]
["Non-Small Cell Lung Cancer Signaling",1.97,0.0957,-0.816,"EGF,EGFR,ERBB2,FHIT,ITPR2,MAPK3,PA2G4,RB1,RXRA","Endocannabinoid Developing Neuron Pathway",1.39,0.0407,-2.236,"GNAI3,KRAS,MAP2K2,NRAS,STAT3","Cardiac Hypertrophy Signaling (Enhanced)",1.97,0.0465,-2.683,"APEX1,CHP1,CTNNB1,DIAPH1,DLG1,FZD1,GNAI2,GNG12,GNG4,HSPB1,IL17RA,ITGA1,ITGA3,ITGA6,ITGB4,PDE11A,PKN1,PLCD1,PLCH2,PRKCD,RALB,ROCK1,RRAS2,SMPDL3B,TDP2","Cardiac Hypertrophy Signaling (Enhanced)",1.97,0.0465,-2.683,"APEX1,CHP1,CTNNB1,DIAPH1,DLG1,FZD1,GNAI2,GNG12,GNG4,HSPB1,IL17RA,ITGA1,ITGA3,ITGA6,ITGB4,PDE11A,PKN1,PLCD1,PLCH2,PRKCD,RALB,ROCK1,RRAS2,SMPDL3B,TDP2","Hedgehog 'on' state",6.79,0.221,4.359,"GRK2,PSMA2,PSMA5,PSMA6,PSMB1,PSMB3,PSMB5,PSMB6,PSMC1,PSMC2,PSMC4,PSMC6,PSMD11,PSMD12,PSMD14,PSMD2,PSMD7,PSME2,PSME3"]
["Actin Nucleation by ARP-WASP Complex",1.55,0.086,-0.816,"ACTR3,ARPC5,ARPC5L,ITGA5,ITGA7,ITGAX,ITGB1,PPP1R12B","Ferroptosis Signaling Pathway",3.84,0.0714,-2.333,"ALOX12B,ALOX15B,ARF6,FTL,G3BP1,KRAS,MAP2K2,NRAS,STAT3","Signaling by Rho Family GTPases",2.77,0.0634,-2.714,"ARHGEF3,ARPC4,GNAI2,GNG12,GNG4,IQGAP1,ITGA1,ITGA3,ITGA6,ITGB4,PI4KA,PIP4K2C,PKN1,ROCK1,SEPTIN10,SEPTIN8,SLC9A1","Signaling by Rho Family GTPases",2.77,0.0634,-2.714,"ARHGEF3,ARPC4,GNAI2,GNG12,GNG4,IQGAP1,ITGA1,ITGA3,ITGA6,ITGB4,PI4KA,PIP4K2C,PKN1,ROCK1,SEPTIN10,SEPTIN8,SLC9A1","D-myo-inositol (1,4,5,6)-Tetrakisphosphate Biosynthesis",3.36,0.121,4.359,"ATP1A2,DUSP23,IGBP1,ILKAP,INPPL1,MTMR2,NUDT2,NUDT4,NUDT5,NUDT9,PGAM5,PPP1CA,PPP1R14B,PPP1R8,PPP3R1,PTPN1,PTPN12,PTPN6,PTPRF,SET,THTPA,WBP11"]
["Pyridoxal 5'-phosphate Salvage Pathway",1.37,0.0909,-0.816,"CDK7,CSNK1D,IRAK1,MAP2K6,MAPK3,PAK1","Actin Nucleation by ARP-WASP Complex",2.51,0.0645,-2.449,"ARPC1A,ARPC3,BAIAP2,ITGA2,KRAS,NRAS","Ephrin Receptor Signaling",1.92,0.0597,-2.828,"ADAM10,ARPC4,GNAI2,GNG12,GNG4,ITGA1,ITGA3,ITGA6,ITGB4,RALB,ROCK1,RRAS2","Ephrin Receptor Signaling",1.92,0.0597,-2.828,"ADAM10,ARPC4,GNAI2,GNG12,GNG4,ITGA1,ITGA3,ITGA6,ITGB4,RALB,ROCK1,RRAS2","D-myo-inositol (3,4,5,6)-tetrakisphosphate Biosynthesis",3.36,0.121,4.359,"ATP1A2,DUSP23,IGBP1,ILKAP,INPPL1,MTMR2,NUDT2,NUDT4,NUDT5,NUDT9,PGAM5,PPP1CA,PPP1R14B,PPP1R8,PPP3R1,PTPN1,PTPN12,PTPN6,PTPRF,SET,THTPA,WBP11"]
["LPS-stimulated MAPK Signaling",1.33,0.0824,-0.816,"CREB1,MAP2K6,MAP3K5,MAPK13,MAPK3,NFKB2,PAK1","Mouse Embryonic Stem Cell Pluripotency",2.27,0.0577,-2.449,"KRAS,LIFR,MAP2K2,NRAS,STAT3,TAB1","Integrin Signaling",1.74,0.0563,-2.887,"ACTN4,ARPC4,CAPN1,CAPN5,DOCK1,ITGA1,ITGA3,ITGA6,ITGB4,RALB,ROCK1,RRAS2","Integrin Signaling",1.74,0.0563,-2.887,"ACTN4,ARPC4,CAPN1,CAPN5,DOCK1,ITGA1,ITGA3,ITGA6,ITGB4,RALB,ROCK1,RRAS2","TNFR2 non-canonical NF-kB pathway",7.77,0.265,4.243,"PSMA2,PSMA5,PSMA6,PSMB1,PSMB3,PSMB5,PSMB6,PSMC1,PSMC2,PSMC4,PSMC6,PSMD11,PSMD12,PSMD14,PSMD2,PSMD7,PSME2,PSME3"]
["Signaling by Rho Family GTPases",5.2,0.101,-0.853,"ACTA1,ACTR3,ARHGEF12,ARHGEF5,ARPC5,ARPC5L,CDC42EP1,CDC42EP4,CDC42EP5,CDH1,CDH11,CDH3,DES,GNA15,GNB1L,GNG10,ITGA5,ITGA7,ITGAX,ITGB1,MAPK3,MYL9,NFKB2,PAK1,PAK4,PPP1R12B,WASF3","fMLP Signaling in Neutrophils",1.8,0.0458,-2.449,"ARPC1A,ARPC3,GNAI3,KRAS,MAP2K2,NRAS","Xenobiotic Metabolism General Signaling Pathway",1.69,0.0629,-3,"GCLC,GSTA2,GSTM2,GSTM3,GSTP1,MGST3,PRKCD,RALB,RRAS2","Xenobiotic Metabolism General Signaling Pathway",1.69,0.0629,-3,"GCLC,GSTA2,GSTM2,GSTM3,GSTP1,MGST3,PRKCD,RALB,RRAS2","ISG15 antiviral mechanism",7.45,0.254,4.243,"AAAS,EIF4A1,EIF4A3,EIF4E,EIF4G1,EIF4G3,FLNB,IFIT1,ISG15,MX2,NUP210,NUP58,NUP98,PPM1B,RANBP2,SEC13,STAT1,UBE2E1"]
["Regulation of Actin-based Motility by Rho",3.25,0.112,-0.905,"ACTA1,ACTR3,ARPC5,ARPC5L,ITGA5,ITGA7,ITGAX,ITGB1,MYL9,PAK1,PAK4,PFN2,PPP1R12B","HGF Signaling",2.37,0.053,-2.646,"ITGA2,KRAS,MAP2K2,MAP3K4,MAP3K6,NRAS,STAT3",{"$nulls":10},"Signaling by NOTCH4",6.34,0.217,4.243,"PSMA2,PSMA5,PSMA6,PSMB1,PSMB3,PSMB5,PSMB6,PSMC1,PSMC2,PSMC4,PSMC6,PSMD11,PSMD12,PSMD14,PSMD2,PSMD7,PSME2,PSME3"]
["Aryl Hydrocarbon Receptor Signaling",2.04,0.0818,-0.905,"AIP,ALDH1A3,ALDH1L2,BAX,MAPK3,NCOR2,NFIA,NFIC,NFIX,NFKB2,RB1,RXRA,TGM2","MSP-RON Signaling In Cancer Cells Pathway",2.26,0.0507,-2.646,"KLK2,KLK3,KRAS,MAP2K2,NRAS,PTK2B,STAT3",{"$nulls":10},"S Phase",7.03,0.21,4.146,"CDK2,CDKN1B,PSMA2,PSMA5,PSMA6,PSMB1,PSMB3,PSMB5,PSMB6,PSMC1,PSMC2,PSMC4,PSMC6,PSMD11,PSMD12,PSMD14,PSMD2,PSMD7,PSME2,PSME3,RBBP4"]
["BAG2 Signaling Pathway",2.28,0.107,-1,"HSPA1A/HSPA1B,HSPA6,MAPK3,NFKB2,PSMA1,PSMA3,PSMA5,PSMB2,PSMB5","GNRH Signaling",1.58,0.0372,-2.646,"GNAI3,KRAS,MAP2K2,MAP3K4,MAP3K6,NRAS,PTK2B",{"$nulls":10},"Signaling by ROBO receptors",7.81,0.207,4.082,"ELOC,EVL,PAK2,PAK4,PRKACB,PRKCA,PSMA2,PSMA5,PSMA6,PSMB1,PSMB3,PSMB5,PSMB6,PSMC1,PSMC2,PSMC4,PSMC6,PSMD11,PSMD12,PSMD14,PSMD2,PSMD7,PSME2,PSME3"]
["Fcγ Receptor-mediated Phagocytosis in Macrophages and Monocytes",1.97,0.0957,-1,"ACTA1,ACTR3,ARPC5,ARPC5L,MAPK3,MYO5A,PAK1,TLN1,VAV2","Signaling by Rho Family GTPases",1.64,0.0336,-2.828,"ARHGEF18,ARPC1A,ARPC3,BAIAP2,GNAI3,ITGA2,MAP2K2,PTK2B,RDX",{"$nulls":10},"C-type lectin receptors (CLRs)",8.28,0.193,4.041,"BCL10,ITPR1,LYN,MALT1,MUCL1,NFKB2,PAK2,PPP3R1,PRKACB,PSMA2,PSMA5,PSMA6,PSMB1,PSMB3,PSMB5,PSMB6,PSMC1,PSMC2,PSMC4,PSMC6,PSMD11,PSMD12,PSMD14,PSMD2,PSMD7,PSME2,PSME3,SYK"]
["4-1BB Signaling in T Lymphocytes",1.38,0.118,-1,"MAP3K5,MAPK13,MAPK3,NFKB2","Rac Signaling",3.55,0.0652,-3,"ARPC1A,ARPC3,BAIAP2,IQGAP2,ITGA2,KRAS,MAP2K2,NRAS,PTK2B",{"$nulls":10},"Spliceosomal Cycle",8.77,0.321,4,"AQR,CASC3,CWC15,DDX23,DDX39B,DDX46,DHX15,DHX38,EIF4A3,LOC102724594/U2AF1,PPIE,SF3B1,SF3B2,SF3B6,SNRNP200,WBP11,XAB2"]
["ErbB Signaling",1.53,0.0851,-1.134,"EGF,EGFR,ERBB2,MAP2K6,MAPK13,MAPK3,PAK1,PAK4","Ephrin Receptor Signaling",3.54,0.0547,-3,"ABI1,ARPC1A,ARPC3,EFNB2,GNAI3,ITGA2,KRAS,MAP2K2,MAP4K4,NRAS,STAT3",{"$nulls":10},"Hedgehog 'off' state",5.49,0.177,3.9,"PRKACB,PSMA2,PSMA5,PSMA6,PSMB1,PSMB3,PSMB5,PSMB6,PSMC1,PSMC2,PSMC4,PSMC6,PSMD11,PSMD12,PSMD14,PSMD2,PSMD7,PSME2,PSME3,TUBB1"]
["Synaptogenesis Signaling Pathway",1.7,0.0641,-1.147,"ACTR3,APOE,ARPC5,ARPC5L,CAMK2D,CDH1,CDH11,CDH3,COMP,CREB1,DLG4,DNAJC5,EIF4EBP1,LRP1,MAPK3,NSF,PAK1,PRKACB,RAB3A,TLN1",{"$nulls":15},"tRNA Charging",8.05,0.359,3.742,"AARS1,AARS2,DARS1,DARS2,EARS2,EPRS1,LARS2,MARS1,NARS1,QARS1,RARS1,TARS1,TARS2,VARS1"]
["Reelin Signaling in Neurons",3.95,0.119,-1.155,"ACTR3,APBB1,APOE,ARHGEF12,ARHGEF5,ARPC5,ARPC5L,CAMK2D,FRK,ITGA5,ITGB1,MAP2K6,MAPK3,PAFAH1B2,PDK3",{"$nulls":15},"Deadenylation-dependent mRNA decay",5.95,0.255,3.742,"CNOT1,EIF4A1,EIF4A3,EIF4B,EIF4E,EIF4G1,LSM1,LSM3,LSM4,LSM6,LSM7,PABPC1,TNKS1BP1,XRN1"]
["Ephrin Receptor Signaling",3.06,0.0896,-1.291,"ACTR3,ARPC5,ARPC5L,CREB1,EGF,GNA15,GNB1L,GNG10,ITGA5,ITGA7,ITGAX,ITGB1,MAPK3,PAK1,PAK4,PTPN13,SDCBP,SORBS1",{"$nulls":15},"Nucleotide Excision Repair",3.08,0.144,3.742,"AQR,COPS7A,CUL4A,LIG3,PCNA,POLR2D,POLR2H,PPIE,RAD23B,SUMO1,TCEA1,USP7,XAB2,XRCC1"]
["Estrogen-Dependent Breast Cancer Signaling",1.48,0.0886,-1.342,"CREB1,DHRS11,EGFR,HSD17B12,IGF1R,MAPK3,NFKB2",{"$nulls":15},"ESR-mediated signaling",2.27,0.119,3.742,"CBFB,CTSD,DDX5,FKBP4,FKBP5,GTF2A1,GTF2F1,H2AC20,HSP90AA1,HSP90AB1,POLR2D,POLR2H,PPID,PTGES3"]
["CCR3 Signaling in Eosinophils",1.43,0.0741,-1.342,"GNA15,GNB1L,GNG10,ITPR2,MAPK13,MAPK3,PAK1,PAK4,PLCB4,PPP1R12B",{"$nulls":15},"Insulin Secretion Signaling Pathway",3.91,0.113,3.651,"CACNA2D1,CAMK2G,EIF2B2,EIF2B5,EIF2S1,EIF2S2,EIF4A1,EIF4A3,EIF4E,EIF4G1,EIF4G3,GOSR1,ITPR1,LYN,NSF,PABPC1,PC,PDIA3,PIK3R1,PRKACB,PRKAG2,PRKCA,SEC61B,SRP14,SRP68,SRP9,SSR3,SSR4,STAT1,STX16,YKT6"]
["Sirtuin Signaling Pathway",1.44,0.0616,-1.508,"ARG2,ATG4C,BAX,CDH1,CYC1,H1-10,H1-3,H1-4,LDHA,MAPK3,MLYCD,NDRG1,NFKB2,POLR1D,PRKDC,TIMM9,UQCRC2,UQCRFS1",{"$nulls":15},"Clathrin-mediated endocytosis",3.11,0.131,3.638,"AP2A2,AP2M1,ARF6,ARPC5,BIN1,CLTA,CTTN,FCHO2,GAK,HIP1R,IGF2R,M6PR,NECAP1,PACSIN2,SCARB2,SH3KBP1,SNX18"]
["B Cell Receptor Signaling",1.4,0.067,-1.508,"CAMK2D,CREB1,IGHG2,IGHG3,MAP2K6,MAP3K3,MAP3K5,MAPK13,MAPK3,NFKB2,OCRL,SYNJ2,VAV2",{"$nulls":15},"TP53 Regulates Transcription of DNA Repair Genes",4,0.186,3.606,"AP1G1,AP1M2,AP1S2,ELOC,GTF2F1,MDC1,MSH2,NELFCD,POLR2D,POLR2H,SSRP1,SUPT5H,TCEA1"]
["Neuregulin Signaling",1.81,0.0855,-1.633,"ADAM17,DLG4,EGF,EGFR,ERBB2,ITGA5,ITGA7,ITGAX,ITGB1,MAPK3",{"$nulls":15},"Gene Silencing by RNA",2.69,0.137,3.606,"AAAS,H2AC20,HSP90AA1,IPO8,NUP210,NUP58,NUP98,POLR2D,POLR2H,RAN,RANBP2,SEC13,TSNAX"]
["GNRH Signaling",2.97,0.0904,-1.807,"CAMK2D,CREB1,EGFR,GNA15,GNB1L,GNG10,ITPR2,MAP2K6,MAP3K3,MAP3K5,MAPK13,MAPK3,NFKB2,PAK1,PAK4,PLCB4,PRKACB",{"$nulls":15},"Cargo recognition for clathrin-mediated endocytosis",2.23,0.121,3.606,"AP2A2,AP2M1,CLTA,COPS7A,FCHO2,GRK2,IGF2R,M6PR,NECAP1,SCARB2,SH3KBP1,TOR1A,UBQLN1"]
["Huntington's Disease Signaling",3.57,0.0854,-1.897,"BAX,CAPNS1,CASP8,CREB1,DLG4,DNAJC5,EGF,EGFR,GNA15,GNB1L,GNG10,HSPA1A/HSPA1B,HSPA6,IGF1R,MAPK3,NCOR2,NSF,PLCB4,PSMA1,PSMA3,PSMA5,PSMB2,PSMB5,TGM2",{"$nulls":15},"Cachexia Signaling Pathway",3.83,0.103,3.569,"AZGP1,CASP1,CASP14,DCD,EIF2B2,EIF2B5,EIF2S1,EIF2S2,HSP90AA1,HSP90AB1,HSPA14,NFKB2,P4HB,PIK3R1,PRKACB,PRKAG2,PRKCA,PSMA2,PSMA5,PSMA6,PSMB1,PSMB3,PSMB5,PSMB6,PSMC1,PSMC2,PSMC4,PSMC6,PSMD11,PSMD12,PSMD14,PSMD2,PSMD7,PSME2,PSME3,STAT1,TGFB1,TSC22D4"]
["Natural Killer Cell Signaling",2.32,0.0804,-2,"COL1A1,COL1A2,COL3A1,HSPA1A/HSPA1B,HSPA6,ITGB1,MAP3K3,MAP3K5,MAPK13,MAPK3,NECTIN2,NFKB2,PAK1,PAK4,TNFSF10,VAV2",{"$nulls":15},"Mitotic Prophase",3.3,0.146,3.357,"AAAS,ARPP19,GOLGA2,GORASP2,H2AC20,LMNB1,NUMA1,NUP210,NUP58,NUP98,PRKCA,RANBP2,SEC13,SET,USO1"]
["Remodeling of Epithelial Adherens Junctions",1.32,0.0882,-2,"ACTA1,ACTR3,ARPC5,ARPC5L,CDH1,VCL",{"$nulls":15},"Metabolism of non-coding RNA",3.77,0.2,3.317,"AAAS,GEMIN4,NCBP1,NUP210,NUP58,NUP98,PRMT5,RANBP2,SEC13,SNRPD1,SNRPD3"]
["RhoA Signaling",4.61,0.129,-2.138,"ABL2,ACTA1,ACTR3,ARHGAP1,ARHGAP8/PRR5-ARHGAP8,ARHGEF12,ARPC5,ARPC5L,CDC42EP1,CDC42EP4,CDC42EP5,IGF1R,MYL9,PFN2,PPP1R12B,SEMA3F",{"$nulls":15},"DNA Damage/Telomere Stress Induced Senescence",3.7,0.196,3.317,"CDK2,CDKN1B,H1-2,H1-5,H2AC20,HMGA1,LMNB1,MRE11,NBN,RAD50,TERF2IP"]
["Semaphorin Neuronal Repulsive Signaling Pathway",3.58,0.106,-2.138,"ARHGEF12,DPYSL3,DPYSL5,ERBB2,ITGA5,ITGA7,ITGAX,ITGB1,MAP2K6,MYL9,PAK1,PAK4,PPP1R12B,PRKACB,PRKG2,SEMA3F",{"$nulls":15},"Signaling by FGFR2",2.69,0.151,3.317,"GTF2F1,HNRNPA1,HNRNPF,HNRNPM,NCBP1,PIK3R1,POLR2D,POLR2H,PTBP1,SHC1,TIA1"]
[{"$nulls":20},"RNA polymerase II transcribes snRNA genes",2.25,0.133,3.317,"GTF2A1,GTF2B,GTF2F1,INTS13,INTS3,NCBP1,POLR2D,POLR2H,RPRD1B,SRRT,SUPT5H"]
[{"$nulls":20},"MHC class II antigen presentation",3.74,0.143,3.3,"AP1G1,AP1M2,AP1S2,AP2A2,AP2M1,CLTA,CTSD,DYNC1I1,HLA-DRB1,KIF5C,LGMN,SEC13,SEC24B,SEC24C,SEC24D,SEC31A,SPTBN2,TUBB1"]
[{"$nulls":20},"Signaling by Rho Family GTPases",1.9,0.0899,3.3,"ARFIP2,ARHGEF2,ARPC5,BAIAP2,CDC42EP1,CDC42EP5,CDH1,CYBB,GFAP,GNAO1,GNB1,ITGA11,ITGAX,ITGB2,ITGB5,MAP3K20,MYLK,NFKB2,PAK2,PAK4,PIK3R1,PIP4K2C,RHOT2,SEPTIN1"]
[{"$nulls":20},"MicroRNA Biogenesis Signaling Pathway",5.38,0.144,3.272,"AAAS,ADAR,DDX17,DDX5,HNRNPA1,HNRNPA2B1,HNRNPD,HSP90AA1,HSP90AB1,ILF3,KHSRP,NUP58,NUP98,PIK3R1,PNPT1,POLR2D,POLR2H,PTGES3,QKI,RAN,RRAS,SEC13,SRSF1,SRSF3,TGFB1,TSNAX,XRN1"]
[{"$nulls":20},"Metabolism of water-soluble vitamins and cofactors",5.56,0.237,3.207,"ACACA,AOX1,COASY,FASN,GPHN,HLCS,MCCC2,MMAB,MMUT,MTR,NFS1,PC,PNPO,THTPA"]
[{"$nulls":20},"SUMOylation of RNA binding proteins",3.79,0.217,3.162,"AAAS,HNRNPC,HNRNPK,NOP58,NUP210,NUP58,NUP98,RANBP2,SEC13,SUMO1"]
[{"$nulls":20},"Interferon alpha/beta signaling",2.28,0.141,3.162,"ADAR,IFIT1,IRF9,ISG15,MX2,OAS3,PTPN1,PTPN6,RNASEL,STAT1"]
[{"$nulls":20},"Sphingolipid metabolism",1.68,0.115,3.162,"ARSA,GBA1,GLA,GM2A,HEXA,HEXB,OSBP,PSAP,SPTLC1,SUMF2"]
[{"$nulls":20},"Processing of Capped Intronless Pre-mRNA",4.79,0.31,3,"CPSF1,CPSF2,CPSF6,CPSF7,CSTF1,CSTF3,NCBP1,PABPN1,SNRPD3"]
[{"$nulls":20},"Cargo concentration in the ER",4.18,0.265,3,"CTSZ,LMAN1,MIA3,SEC23B,SEC24B,SEC24C,SEC24D,STX5,TMED10"]
[{"$nulls":20},"SUMOylation of DNA replication proteins",3.18,0.2,3,"AAAS,NUP210,NUP58,NUP98,PCNA,RANBP2,SEC13,SUMO1,TOP2B"]
[{"$nulls":20},"XBP1(S) activates chaperone genes",2.97,0.188,3,"DNAJC3,GFPT1,HDGF,HYOU1,MYDGF,PDIA5,SEC31A,SHC1,TPP1"]
[{"$nulls":20},"B-WICH complex positively regulates rRNA expression",2.72,0.173,3,"BAZ1B,DDX21,DEK,H2AC20,MYBBP1A,POLR1C,POLR2H,SF3B1,SMARCA5"]
[{"$nulls":20},"Apoptotic execution phase",2.72,0.173,3,"CDH1,CTNNB1,DSG2,DSP,FNTA,H1-2,H1-5,LMNB1,PAK2"]
[{"$nulls":20},"E3 ubiquitin ligases ubiquitinate target proteins",2.54,0.164,3,"BCL10,DERL1,PAF1,PCNA,PEX14,PRKDC,RNF20,UBE2E1,VCP"]
[{"$nulls":20},"Folate Signaling Pathway",2.49,0.161,3,"CDKN1B,GART,GGH,MAT2A,MTR,NFKB2,PFAS,PPAT,SHMT2"]
[{"$nulls":20},"Peroxisomal protein import",2.14,0.143,3,"ACAA1,ACOX1,AMACR,CROT,HSD17B4,IDH1,NUDT19,PEX14,SCP2"]
[{"$nulls":20},"Phase II - Conjugation of compounds",1.97,0.134,3,"ABHD14B,BPNT1,CNDP2,GGT5,MAT2A,MTR,PAPSS1,TPMT,UGDH"]
[{"$nulls":20},"Epithelial Adherens Junction Signaling",1.87,0.101,3,"AFDN,ARPC5,BAIAP2,CDH1,CTNNA1,CTNNB1,CTNND1,DIAPH1,FRMD6,NECTIN2,PAK2,PAK4,PRKAG2,RRAS,SFN,VAV2"]
[{"$nulls":20},"SUMOylation of DNA damage response and repair proteins",1.63,0.118,3,"AAAS,MDC1,NUP210,NUP58,NUP98,PML,RANBP2,SEC13,SUMO1"]
[{"$nulls":20},"Signaling by VEGF",5.81,0.185,2.982,"ABI1,BAIAP2,BCAR1,CAV1,CTNNA1,CTNNB1,CTNND1,CYBB,HSP90AA1,ITPR1,JUP,MLST8,NCF4,NCKAP1L,PAK2,PIK3R1,PRKACB,PRKCA,VAV1,VAV2"]
[{"$nulls":20},"UFMylation Signaling Pathway",3.92,0.194,2.887,"EIF4A1,EIF4A3,EIF4E,EIF4G1,EIF4G3,MRE11,NBN,NFKB2,PABPC1,RAD50,RPL26,UBA5"]
[{"$nulls":20},"Glucose metabolism",2.87,0.15,2.887,"AAAS,FBP1,NUP210,NUP58,NUP98,PC,PFKL,PRKACB,RANBP2,SEC13,SLC25A1,SLC25A13"]
[{"$nulls":20},"Colanic Acid Building Blocks Biosynthesis",6.74,0.571,2.828,"GALE,GALK2,GFUS,GMDS,GMPPA,GMPPB,PMM2,UGDH"]
[{"$nulls":20},"Sulfur amino acid metabolism",4.57,0.333,2.828,"ADO,CTH,ETHE1,MPST,MTR,SQOR,TST,TSTD1"]
[{"$nulls":20},"Fatty Acid β-oxidation I",4.18,0.265,2.828,"ACAA1,ACSF2,ACSL1,ACSL3,AUH,ECI1,HSD17B10,HSD17B4,SCP2"]
[{"$nulls":20},"Asparagine N-linked glycosylation",3.69,0.258,2.828,"ALG1,ALG2,GFPT1,MVD,NAGK,PDIA3,PGM3,UAP1"]
[{"$nulls":20},"SUMOylation of ubiquitinylation proteins",3.04,0.211,2.828,"AAAS,NUP210,NUP58,NUP98,PML,RANBP2,SEC13,SUMO1"]
[{"$nulls":20},"Cytosolic sensors of pathogen-associated DNA",2.48,0.174,2.828,"CTNNB1,DHX9,LRRFIP1,MRE11,NFKB2,PRKDC,TRIM56,XRCC6"]
[{"$nulls":20},"TP53 Regulates Transcription of Cell Cycle Genes",2.31,0.163,2.828,"BAX,CDK2,CDKN1B,CNOT1,NPM1,PCNA,SFN,TNKS1BP1"]
[{"$nulls":20},"Signaling by TGF-beta Receptor Complex",2.1,0.151,2.828,"CGN,FKBP1A,ITGB5,NEDD4L,PPP1CA,STRAP,TGFB1,UCHL5"]
[{"$nulls":20},"Regulation of Actin-based Motility by Rho",1.61,0.104,2.828,"ARHGDIA,ARPC5,BAIAP2,ITGA11,ITGAX,ITGB2,ITGB5,MYLK,PAK2,PAK4,PIP4K2C,RHOT2"]
[{"$nulls":20},"RAB geranylgeranylation",1.59,0.123,2.828,"CHM,RAB22A,RAB27A,RAB33B,RAB3A,RAB3B,RAB3D,RAB6A"]
[{"$nulls":20},"RAC Signaling",2.08,0.109,2.714,"ARFIP2,ARPC5,BAIAP2,CYBB,IQGAP2,ITGA11,ITGAX,ITGB2,ITGB5,NFKB2,PAK2,PAK4,PIK3R1,PIP4K2C,RRAS"]
[{"$nulls":20},"Salvage Pathways of Pyrimidine Ribonucleotides",1.76,0.113,2.714,"AK1,APOBEC3G,CDK2,CMPK1,CSNK1D,MAP2K3,NME1,NME2,NME3,PAK2,PRPF4B"]
[{"$nulls":20},"Regulation of Insulin-like Growth Factor (IGF) transport and uptake by IGFBPs",2.08,0.113,2.673,"APLP2,CHGB,DNAJC3,FUCA2,GOLM1,IGFBP7,KLK2,KLK3,MEN1,MIA3,MXRA8,NUCB1,P4HB,VWA1"]
[{"$nulls":20},"Ribonucleotide Reductase Signaling Pathway",1.3,0.0877,2.673,"ARID1A,CDH1,CDK2,CTNNB1,EIF4E,MLST8,NFKB2,NFYC,PARP12,PBRM1,PIK3R1,RRM1,SMARCB1,SMARCD2,YBX1"]
[{"$nulls":20},"Fatty acyl-CoA biosynthesis",3.3,0.259,2.646,"ACACA,ACLY,ACSF3,ACSL1,ACSL3,FASN,SLC25A1"]
[{"$nulls":20},"MTOR signalling",3.2,0.25,2.646,"EIF4B,EIF4E,EIF4G1,FKBP1A,LAMTOR3,MLST8,RHEB"]
[{"$nulls":20},"SUMOylation of SUMOylation proteins",2.66,0.206,2.646,"AAAS,NUP210,NUP58,NUP98,RANBP2,SEC13,SUMO1"]
[{"$nulls":20},"Detoxification of Reactive Oxygen Species",2.44,0.189,2.646,"CYBB,GPX1,GPX3,NCF4,NUDT2,P4HB,SOD1"]
[{"$nulls":20},"Interleukin-2 family signaling",1.91,0.152,2.646,"INPPL1,LGALS9,PIK3R1,PTPN6,SHC1,STAT1,SYK"]
[{"$nulls":20},"RNA Polymerase I Transcription",1.73,0.14,2.646,"CHD4,GATAD2B,MTA2,POLR1C,POLR2H,RBBP4,UBTF"]
[{"$nulls":20},"Interleukin-3, Interleukin-5 and GM-CSF signaling",1.52,0.127,2.646,"INPPL1,LYN,PIK3R1,PTPN6,SHC1,SYK,VAV1"]
[{"$nulls":20},"SUMOylation of chromatin organization proteins",1.48,0.125,2.646,"AAAS,NUP210,NUP58,NUP98,RANBP2,SEC13,SUMO1"]
[{"$nulls":20},"DNA Double Strand Break Response",1.38,0.119,2.646,"BAZ1B,MDC1,MRE11,NBN,RAD50,SMARCA5,SUMO1"]
[{"$nulls":20},"Pyrimidine Ribonucleotides De Novo Biosynthesis",4.06,0.233,2.53,"AK1,CANT1,CMPK1,DDX3X,DHX9,NME1,NME2,NME3,NUDT5,UMPS"]
[{"$nulls":20},"NER (Nucleotide Excision Repair, Enhanced Pathway)",2.86,0.143,2.53,"COPS7A,CUL4A,LIG3,PCNA,POLR2D,POLR2H,RAD23B,RBBP4,TCEA1,TOP2B,USP7,XAB2,XRCC1"]
[{"$nulls":20},"Cellular response to heat stress",5.93,0.196,2.496,"AAAS,CAMK2G,DNAJC2,DNAJC7,FKBP4,HSBP1,HSP90AA1,HSP90AB1,HSPA12A,HSPA14,HSPB8,HSPH1,MLST8,NUP210,NUP58,NUP98,PTGES3,RANBP2,SEC13"]
[{"$nulls":20},"L1CAM interactions",1.7,0.104,2.496,"ALCAM,AP2A2,AP2M1,CLTA,DLG1,LYPLA2,NCAM1,RANBP9,RPS6KA3,SHTN1,SPTBN2,TUBB1,VAV2"]
[{"$nulls":20},"HDR through MMEJ (alt-NHEJ)",4.72,0.5,2.449,"FEN1,LIG3,MRE11,NBN,RAD50,XRCC1"]
[{"$nulls":20},"Superpathway of Geranylgeranyldiphosphate Biosynthesis I (via Mevalonate)",3.55,0.333,2.449,"ACAT2,FDPS,GGPS1,HMGCS2,MVD,PMVK"]
[{"$nulls":20},"Superpathway of Cholesterol Biosynthesis",2.36,0.207,2.449,"ACAT2,FDPS,GGPS1,HMGCS2,MVD,PMVK"]
[{"$nulls":20},"Regulation of TP53 Activity through Acetylation",2.29,0.2,2.449,"CHD4,GATAD2B,MTA2,PIP4K2C,PML,RBBP4"]
[{"$nulls":20},"Protein ubiquitination",2.29,0.2,2.449,"OTULIN,UBA1,UBE2E1,UBE2K,UCHL3,USP7"]
[{"$nulls":20},"GPVI-mediated activation cascade",1.95,0.171,2.449,"LYN,PIK3R1,PTPN6,SYK,VAV1,VAV2"]
[{"$nulls":20},"ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression",1.83,0.162,2.449,"CBX3,CHD4,GATAD2B,H2AC20,MTA2,RBBP4"]
[{"$nulls":20},"Resolution of Abasic Sites (AP sites)",1.78,0.158,2.449,"ADPRS,APEX1,FEN1,LIG3,PCNA,XRCC1"]
[{"$nulls":20},"Superpathway of Methionine Degradation",1.73,0.154,2.449,"AHCYL2,CTH,MAT2A,MMUT,MTR,PRMT5"]
[{"$nulls":20},"Activation of gene expression by SREBF (SREBP)",1.63,0.146,2.449,"FASN,FDPS,GGPS1,MVD,NFYC,PMVK"]
[{"$nulls":20},"Signaling by Insulin receptor",1.54,0.14,2.449,"ATP6AP1,ATP6V0A1,PIK3R1,PTPN1,PTPRF,SHC1"]
[{"$nulls":20},"SUMOylation of transcription cofactors",1.49,0.136,2.449,"DDX17,DDX5,NPM1,SAFB,SUMO1,TRIM28"]
[{"$nulls":20},"BER (Base Excision Repair) Pathway",1.49,0.136,2.449,"APEX1,FEN1,LIG3,MAP2K3,PCNA,XRCC1"]
[{"$nulls":20},"Sertoli Cell-Sertoli Cell Junction Signaling",1.56,0.0864,2.4,"AFDN,CDH1,CGN,CLINT1,CTNNA1,CTNNB1,DLG1,JAM3,JUP,LAMA2,MAP2K3,MAP3K20,NECTIN2,NFKB2,PAK2,PAK4,PALS2,PIK3R1,RRAS,SPTBN2,TUBB1"]
[{"$nulls":20},"Pyrimidine Ribonucleotides Interconversion",3.59,0.225,2.333,"AK1,CANT1,CMPK1,DDX3X,DHX9,NME1,NME2,NME3,NUDT5"]
[{"$nulls":20},"Regulation of mRNA stability by proteins that bind AU-rich elements",3.26,0.205,2.333,"ANP32A,EIF4G1,ELAVL1,HNRNPD,KHSRP,PABPC1,PRKCA,SET,XRN1"]
[{"$nulls":20},"CSDE1 Signaling Pathway",2.49,0.161,2.333,"CTNNB1,CTTN,HNRNPC,HNRNPD,LSM14A,PABPC1,PABPN1,PTBP1,TGFB1"]
[{"$nulls":20},"Post-translational protein phosphorylation",1.84,0.112,2.309,"APLP2,CHGB,DNAJC3,FUCA2,GOLM1,IGFBP7,MEN1,MIA3,MXRA8,NUCB1,P4HB,VWA1"]
[{"$nulls":20},"Purine Nucleotides De Novo Biosynthesis II",3.76,0.455,2.236,"ADSS2,GART,GMPS,PFAS,PPAT"]
[{"$nulls":20},"Isoleucine Degradation I",3.7,0.353,2.236,"ACAD8,ACADSB,ACAT2,AUH,HSD17B10,HSD17B4"]
[{"$nulls":20},"Valine Degradation I",3.27,0.3,2.236,"ABAT,ACAD8,ACADSB,ALDH6A1,AUH,HSD17B4"]
[{"$nulls":20},"Branched-chain amino acid catabolism",2.63,0.278,2.236,"ACAD8,ACADSB,ALDH6A1,AUH,HSD17B10"]
[{"$nulls":20},"Insertion of tail-anchored proteins into the endoplasmic reticulum membrane",2.22,0.227,2.236,"BAG6,GET3,SEC61B,STX5,UBL4A"]
[{"$nulls":20},"Insulin processing",1.98,0.2,2.236,"EXOC8,KIF5C,MYO5A,P4HB,RAB27A"]
[{"$nulls":20},"Integrin signaling",1.84,0.185,2.236,"BCAR1,CSK,PTPN1,SHC1,SYK"]
[{"$nulls":20},"mRNA Capping",1.71,0.172,2.236,"GTF2F1,NCBP1,POLR2D,POLR2H,SUPT5H"]
[{"$nulls":20},"Signaling by CSF3 (G-CSF)",1.65,0.167,2.236,"ELOC,LYN,SHC1,STAT1,SYK"]
[{"$nulls":20},"Signaling by CSF1 (M-CSF) in myeloid cells",1.59,0.161,2.236,"INPPL1,LYN,PIK3R1,SHC1,STAT1"]
[{"$nulls":20},"RHO GTPases Activate WASPs and WAVEs",1.34,0.139,2.236,"ABI1,ARPC5,BAIAP2,NCKAP1L,WIPF2"]
[{"$nulls":20},"Pyrimidine Deoxyribonucleotides De Novo Biosynthesis I",4.72,0.348,2.121,"AK1,APOBEC3G,CMPK1,DTYMK,NME1,NME2,NME3,RRM1"]
[{"$nulls":20},"Coronavirus Replication Pathway",2.55,0.178,2.121,"ARCN1,COPA,COPB1,COPB2,COPE,COPG1,HNRNPA1,TUBB1"]
[{"$nulls":20},"mTOR Signaling",11.1,0.187,2.111,"EIF3B,EIF3F,EIF3G,EIF3J,EIF4A1,EIF4A3,EIF4B,EIF4E,EIF4G1,EIF4G3,FKBP1A,MLST8,PIK3R1,PRKAG2,PRKCA,RHEB,RHOT2,RPS10,RPS11,RPS13,RPS15A,RPS16,RPS18,RPS19,RPS20,RPS23,RPS24,RPS25,RPS26,RPS28,RPS3,RPS3A,RPS4X,RPS4Y1,RPS5,RPS6KA3,RPS7,RPS8,RPS9,RRAS"]
[{"$nulls":20},"Interferon gamma signaling",1.85,0.117,2.111,"CAMK2G,HLA-DRB1,IFI30,IRF9,NCAM1,OAS3,PML,PTPN1,PTPN6,STAT1,SUMO1"]
[{"$nulls":20},"Extracellular matrix organization",1.51,0.104,2.111,"AGRN,ASPN,COMP,DDR1,ITGAX,ITGB5,LAMA2,NCAM1,NID2,SPARC,TGFB1"]
[{"$nulls":20},"TYSND1 cleaves peroxisomal proteins",3.56,0.571,2,"ACAA1,ACOX1,HSD17B4,SCP2"]
[{"$nulls":20},"γ-glutamyl Cycle",2.5,0.333,2,"GGCT,GGT5,GSS,OPLAH"]
[{"$nulls":20},"Mevalonate Pathway I",2.23,0.286,2,"ACAT2,HMGCS2,MVD,PMVK"]
[{"$nulls":20},"Regulation of cholesterol biosynthesis by SREBP (SREBF)",2.12,0.267,2,"RAN,SEC24B,SEC24C,SEC24D"]
[{"$nulls":20},"Chondroitin Sulfate Degradation (Metazoa)",2.01,0.25,2,"GALNS,GM2A,HEXA,HEXB"]
[{"$nulls":20},"Mismatch Repair in Eukaryotes",1.83,0.222,2,"FEN1,MSH2,MSH6,PCNA"]
[{"$nulls":20},"Peroxisomal lipid metabolism",1.52,0.182,2,"ACOX1,AMACR,HSD17B4,SCP2"]
[{"$nulls":20},"Growth hormone receptor signaling",1.4,0.167,2,"LYN,PTPN1,PTPN6,STAT1"]
[{"$nulls":20},"Interferon Signaling",1.34,0.139,2,"BAX,IFIT1,IRF9,ISG15,STAT1"]
[{"$nulls":20},"Cholesterol biosynthesis",1.34,0.16,2,"ACAT2,FDPS,GGPS1,MVD"]
[{"$nulls":20},"Signaling by Erythropoietin",1.34,0.16,2,"LYN,PIK3R1,SHC1,VAV1"]
[{"$nulls":20},"Signaling by ERBB2",1.73,0.14,1.89,"DIAPH1,HSP90AA1,MEMO1,PIK3R1,PRKCA,PTPN12,SHC1"]
[{"$nulls":20},"Interconversion of nucleotide di- and triphosphates",3.02,0.273,1.633,"AK1,CMPK1,DTYMK,GUK1,NME1,NME2"]
[{"$nulls":20},"RHO GTPases activate IQGAPs",2.21,0.194,1.633,"CDH1,CTNNA1,CTNNB1,IQGAP2,MEN1,TUBB1"]
[{"$nulls":20},"Signaling by SCF-KIT",1.54,0.14,1.633,"LYN,PIK3R1,PRKCA,PTPN6,STAT1,VAV1"]
[{"$nulls":20},"Insulin Receptor Signaling",1.99,0.107,1.604,"ACLY,EIF2B2,EIF2B5,EIF4E,EPM2A,INPPL1,PIK3R1,PPP1CA,PPP1R14B,PRKACB,PRKAG2,PTPN1,PTPRF,RRAS,SHC1"]
[{"$nulls":20},"Leukocyte Extravasation Signaling",1.43,0.0881,1.604,"AFDN,ARHGAP4,BCAR1,CTNNA1,CTNNB1,CTNND1,CTTN,CYBB,ITGB2,JAM3,MMP14,NCF4,PIK3R1,PRKCA,SIPA1,VAV1,VAV2"]
[{"$nulls":20},"CLEAR Signaling Pathway",4.35,0.116,1.567,"ASAH1,ATP6AP1,ATP6V0A1,CTSD,GAA,GALNS,GBA1,GLA,GNS,GUSB,HEXA,HEXB,IFI30,IGF2R,ITPR1,LAMP1,LAMTOR3,M6PR,MLST8,NAGLU,PLBD2,PML,PPP3R1,PRKAG2,PRKCA,PSAP,RHEB,RRAS,SEC13,SFN,SGSH,TGFB1,TPP1"]
[{"$nulls":20},"Synaptogenesis Signaling Pathway",2.33,0.0921,1.512,"AFDN,AP2A2,AP2M1,ARPC5,CACNA2D1,CAMK2G,CDH1,COMP,CTNNB1,CTNND1,EPHB4,FARP1,GOSR1,ITPR1,LYN,MAP1B,NSF,PIK3R1,PRKACB,PRKAG2,RAB3A,RRAS,SHC1,SNCG,STX16,STXBP2,SYT7,THBS4,YKT6"]
[{"$nulls":20},"HSP90 chaperone cycle for steroid hormone receptors in the presence of ligand",2,0.145,1.414,"DYNC1I1,FKBP4,FKBP5,HSP90AA1,HSP90AB1,PTGES3,STIP1,TUBB1"]
[{"$nulls":20},"Metabolism of nitric oxide: NOS3 activation and regulation",3.03,0.333,1.342,"CAV1,DDAH1,DDAH2,HSP90AA1,LYPLA1"]
[{"$nulls":20},"Chaperone Mediated Autophagy",2.22,0.227,1.342,"GFAP,HSP90AA1,HSP90AB1,LAMP2,PLIN3"]
[{"$nulls":20},"Energy dependent regulation of mTOR by LKB1-AMPK",1.71,0.172,1.342,"LAMTOR3,MLST8,PPM1A,PRKAG2,RHEB"]
[{"$nulls":20},"Remodeling of Epithelial Adherens Junctions",1.49,0.118,1.342,"ARF6,ARPC5,CDH1,CTNNA1,CTNNB1,CTNND1,NME1,TUBB1"]
[{"$nulls":20},"Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors",1.34,0.139,1.342,"DEK,HSPD1,NOP2,NPM1,SUMO1"]
[{"$nulls":20},"SNARE Signaling Pathway",2.1,0.11,1.291,"CACNA2D1,CAMK2G,GOSR1,NSF,PRKACB,PRKAG2,RAB22A,RAB27A,RAB3A,RAB6A,SNCG,STX16,STXBP2,SYT7,YKT6"]
[{"$nulls":20},"NRF2-mediated Oxidative Stress Response",2.85,0.105,1.155,"ABCC1,ABCC4,AKR1A1,AOX1,CLPP,DNAJA3,DNAJC17,DNAJC3,DNAJC7,EPHX1,FKBP5,GSTM2,GSTM3,GSTZ1,HSP90AA1,HSP90AB1,HSPB8,MAP2K3,PIK3R1,PRKCA,RRAS,SOD1,STIP1,UBE2K,VCP"]
[{"$nulls":20},"Ferroptosis Signaling Pathway",1.55,0.0992,1.155,"ACACA,ARF4,ARF5,ARF6,CTH,CYBB,DPP4,GSS,H2AC20,NFS1,PRKAG2,RRAS,USP7"]
[{"$nulls":20},"PI3K/AKT Signaling",1.3,0.085,1.155,"CDKN1B,CTNNB1,EIF4E,EPM2A,HSP90AA1,HSP90AB1,INPPL1,ITGA11,ITGAX,ITGB2,ITGB5,NFKB2,PIK3R1,RHEB,RRAS,SFN,SHC1"]
[{"$nulls":20},"Integrin Signaling",1.6,0.0896,1.147,"ARF4,ARF5,ARF6,ARPC5,BCAR1,CAV1,CTTN,ILKAP,ITGA11,ITGAX,ITGB2,ITGB5,MYLK,PAK2,PAK4,PIK3R1,RHOT2,RRAS,SHC1"]
[{"$nulls":20},"Glutamate binding, activation of AMPA receptors and synaptic plasticity",2.83,0.219,1.134,"AP2A2,AP2M1,CAMK2G,DLG1,MYO6,NSF,PRKCA"]
[{"$nulls":20},"p53 Signaling",1.73,0.112,1.134,"BAX,CDK2,CSNK1D,CTNNB1,JMY,PCNA,PIK3R1,PML,PRKDC,SFN,TP53I3"]
[{"$nulls":20},"Ephrin B Signaling",1.36,0.111,1.134,"ABI1,CTNNB1,EPHB4,GNAO1,GNB1,HNRNPK,VAV1,VAV2"]
[{"$nulls":20},"Role of BRCA1 in DNA Damage Response",2.87,0.15,1,"ARID1A,ATF1,MDC1,MRE11,MSH2,MSH6,NBN,PBRM1,RAD50,SMARCB1,SMARCD2,STAT1"]
[{"$nulls":20},"Glycogen Degradation III",2.36,0.308,1,"GAA,PGM2,PGM3,PYGB"]
[{"$nulls":20},"Paxillin Signaling",2.23,0.121,1,"ARF6,ARFIP2,BCAR1,CSK,ITGA11,ITGAX,ITGB2,ITGB5,PAK2,PAK4,PIK3R1,PTPN12,RRAS"]
[{"$nulls":20},"Metabolism of Angiotensinogen to Angiotensins",1.83,0.222,1,"CES1,CTSD,CTSZ,ENPEP"]
[{"$nulls":20},"Unfolded protein response",1.59,0.111,1,"DNAJA3,DNAJC17,DNAJC3,DNAJC7,HSPA14,HSPH1,OS9,P4HB,SEL1L,VCP"]
[{"$nulls":20},"Triglyceride metabolism",2.01,0.176,0.816,"CAV1,FABP5,GPD2,PLIN3,PPP1CA,PRKACB"]
[{"$nulls":20},"VEGF Signaling",1.7,0.111,0.816,"EIF2B2,EIF2B5,EIF2S1,EIF2S2,ELAVL1,PIK3R1,PRKCA,PTPN6,RRAS,SFN,SHC1"]
[{"$nulls":20},"ATM Signaling",1.32,0.1,0.816,"ATF1,CBX3,CDK2,MDC1,MRE11,NBN,RAD50,TRIM28,TRRAP,USP7"]
[{"$nulls":20},"HER-2 Signaling in Breast Cancer",1.34,0.0837,0.775,"AAAS,ARF4,ARF5,ARF6,CDKN1B,COX7A1,ITGB2,ITGB5,LYN,MLST8,NFKB2,NUP58,NUP98,PIK3R1,PRKCA,RHEB,RRAS,SEC13,TP53RK"]
[{"$nulls":20},"Netrin Signaling",1.83,0.0983,0.728,"ABLIM1,ARPC5,CACNA2D1,CAMK2G,GOSR1,ITPR1,NEO1,NFKB2,NSF,PIK3R1,PPP3R1,PRKACB,PRKAG2,PRKCA,PRKG1,STX16,YKT6"]
[{"$nulls":20},"ERK/MAPK Signaling",1.55,0.0884,0.535,"ATF1,BCAR1,EIF4E,ITGA11,ITGAX,ITGB2,ITGB5,LAMTOR3,PAK2,PAK4,PIK3R1,PPP1CA,PPP1R14B,PRKACB,PRKAG2,PRKCA,RRAS,SHC1,STAT1"]
[{"$nulls":20},"Aldosterone Signaling in Epithelial Cells",2.18,0.105,0.447,"DNAJC17,DNAJC2,DNAJC3,DNAJC7,HSP90AA1,HSP90AB1,HSPA12A,HSPA14,HSPB8,HSPD1,HSPE1,HSPH1,ITPR1,PDIA3,PIK3R1,PIP4K2C,PRKCA,TRAP1"]
[{"$nulls":20},"Gene and protein expression by JAK-STAT signaling after IL-12 stimulation",5.52,0.297,0.302,"CNN2,HNRNPA2B1,HNRNPF,LCP1,LMNB1,PAK2,PDCD4,PPIA,PSME2,SNRPA1,SOD1"]
[{"$nulls":20},"Renin-Angiotensin Signaling",1.46,0.0992,0.302,"ITPR1,NFKB2,PAK2,PAK4,PIK3R1,PRKACB,PRKAG2,PRKCA,PTPN6,RRAS,SHC1,STAT1"]
[{"$nulls":20},"BAG2 Signaling Pathway",8.36,0.247,-0.447,"HSP90AA1,HSPA14,NFKB2,PSMA2,PSMA5,PSMA6,PSMB1,PSMB3,PSMB5,PSMB6,PSMC1,PSMC2,PSMC4,PSMC6,PSMD11,PSMD12,PSMD14,PSMD2,PSMD7,PSME2,PSME3"]
[{"$nulls":20},"AMPK Signaling",3.78,0.116,-0.447,"ACACA,AK1,ARID1A,CAMKK2,CPT2,ELAVL1,EPM2A,FASN,GNAO1,GNB1,ILKAP,MAP2K3,MLST8,PBRM1,PFKL,PIK3R1,PPAT,PPM1A,PPM1B,PPM1G,PRKACB,PRKAG2,RAB22A,RAB27A,RAB3A,RAB6A,SMARCB1,SMARCD2"]
[{"$nulls":20},"DAG and IP3 signaling",1.63,0.146,-0.447,"CAMK2G,CAMKK2,GRK2,ITPR1,PRKACB,PRKCA"]
[{"$nulls":20},"Inhibition of ARE-Mediated mRNA Degradation Pathway",6.03,0.16,-0.632,"CNOT1,PABPN1,PRKACB,PRKAG2,PSMA2,PSMA5,PSMA6,PSMB1,PSMB3,PSMB5,PSMB6,PSMC1,PSMC2,PSMC4,PSMC6,PSMD11,PSMD12,PSMD14,PSMD2,PSMD7,PSME2,PSME3,SFN,TIA1,XRN1,ZFP36L2"]
[{"$nulls":20},"Granzyme A Signaling",2.15,0.135,-0.632,"ANP32A,APEX1,CASP1,H1-2,H1-5,LMNB1,MT-ND2,NME1,SET,XRCC6"]
[{"$nulls":20},"Sertoli Cell-Germ Cell Junction Signaling Pathway (Enhanced)",1.69,0.089,-0.655,"AFDN,ARPC5,BCAR1,CD2AP,CDH1,CTNNA1,CTNNB1,CTNND1,JAM3,JUP,LAMA2,MAP2K3,MTMR2,NECTIN2,NFKB2,PIK3R1,PRKACB,PRKAG2,PRKG1,RRAS,TGFB1"]
[{"$nulls":20},"Androgen Signaling",1.34,0.0888,-0.816,"CACNA2D1,GNAO1,GNB1,GTF2A1,GTF2B,GTF2F1,HSP90AA1,ITPR1,NFKB2,POLR2D,POLR2H,PRKACB,PRKAG2,PRKCA,SHC1"]
[{"$nulls":20},"Xenobiotic Metabolism AHR Signaling Pathway",2.1,0.126,-0.905,"ALDH18A1,ALDH2,ALDH6A1,GSTM2,GSTM3,GSTZ1,HSP90AA1,HSP90AB1,NFKB2,PTGES3,SUMO1"]
[{"$nulls":20},"Aryl Hydrocarbon Receptor Signaling",1.54,0.0943,-1,"ALDH18A1,ALDH2,ALDH6A1,BAX,CDK2,CDKN1B,CTSD,GSTM2,GSTM3,GSTZ1,HSP90AA1,HSP90AB1,NFKB2,PTGES3,TGFB1"]
[{"$nulls":20},"PPARα/RXRα Activation",1.41,0.0876,-1,"ACAA1,ACOX1,AP2A2,FASN,GPD2,HSP90AA1,HSP90AB1,ITGB5,MAP2K3,NFKB2,PDIA3,PRKACB,PRKAG2,PRKCA,RRAS,SHC1,TGFB1"]
[{"$nulls":20},"Huntington's Disease Signaling",6.88,0.137,-1.155,"AP2A2,ARFIP2,BAX,CASP1,CASP14,CLTA,CTSD,GNB1,GOSR1,HSPA14,HTT,ITPR1,NSF,PIK3R1,POLR2D,POLR2H,PRKCA,PSMA2,PSMA5,PSMA6,PSMB1,PSMB3,PSMB5,PSMB6,PSMC1,PSMC2,PSMC4,PSMC6,PSMD11,PSMD12,PSMD14,PSMD2,PSMD7,PSME2,PSME3,SHC1,STX16,TCERG1,YKT6"]
[{"$nulls":20},"Sumoylation Pathway",1.96,0.117,-1.414,"ARHGDIA,CDH1,CTBP2,NFKB2,PCNA,PML,RAN,RANBP2,RCC1,RHOT2,SAE1,SUMO1"]
[{"$nulls":20},"ROBO SLIT Signaling Pathway",2,0.11,-1.604,"ARF4,ARF5,ARF6,ARPC5,CDH1,CTNNB1,CTNND1,LYN,MMP14,PAK2,PAK4,PRKACB,PRKAG2,TGFB1"]
[{"$nulls":20},"Coronavirus Pathogenesis Pathway",9.9,0.181,-4.11,"ATP6AP1,BAX,CASP1,CDK2,EEF1A2,EIF4E,IRF9,NFKB2,NPC1,NPM1,NUP98,OAS3,PA2G4,RPS10,RPS11,RPS13,RPS15A,RPS16,RPS18,RPS19,RPS20,RPS23,RPS24,RPS25,RPS26,RPS28,RPS3,RPS3A,RPS4X,RPS4Y1,RPS5,RPS7,RPS8,RPS9,STAT1,TGFB1,ZC3HAV1"]

{"sheet":"Supplemental Table 10","index":10,"n_rows":10,"n_cols":28,"rows_kept":10,"merged":[[0,0,0,6],[0,7,0,13],[0,14,0,20],[0,21,0,27]]}
["FDA-approved Drug Targets: LogFC(Gleason6tumorVSGleason6benignepithelium)",{"$nulls":6},"FDA-approved Drug Targets: LogFC(Gleason9tumorVSGleason9benignepithelium)",{"$nulls":6},"FDA-approved Drug Targets: Overlap (Gleason 6 ET vs BE Log ratio; Gleason 9 ET vs BE Log ratio)",{"$nulls":6},"FDA-approved Drug Targets: LogFC(Gleason9involvedstromaVSGleason9benignstroma)"]
["Expr Log Ratio","ID","Symbol","Entrez Gene Name","Location","Type(s)","FDA-approved drug","Expr Log Ratio","ID","Symbol","Entrez Gene Name","Location","Type(s)","FDA-approved drug","Expr Log Ratio","ID","Symbol","Entrez Gene Name","Location","Type(s)","FDA-approved drug","Expr Log Ratio","ID","Symbol","Entrez Gene Name","Location","Type(s)","FDA-approved drug"]
[0.715,"P09619","PDGFRB","platelet derived growth factor receptor beta","Plasma Membrane","kinase","Sorafenib tosylate;Sunitinib malate;Pazopanib hydrochloride;Regorafenib",1.053,"P23921","RRM1","ribonucleotide reductase catalytic subunit M1","Nucleus","enzyme","Gemcitabine;Hydroxyurea","0.254;0.517","P07437","TUBB","tubulin beta class I","Cytoplasm","other","Vincristine sulfate;Vinblastine sulfate;Vinorelbine tartrate",0.769,"P26358","DNMT1","DNA methyltransferase 1","Nucleus","enzyme","Azacitidine, Decitabine"]
[0.643,"P42685","FRK","fyn related Src family tyrosine kinase","Nucleus","kinase","Regorafenib",0.632,"Q02880","TOP2B","DNA topoisomerase II beta","Nucleus","enzyme","Etoposide;Daunorubicin hydrochloride","-0.421;-0.522","P23258","TUBG1","tubulin gamma 1","Cytoplasm","other","Vinblastine sulfate",0.649,"P39023","RPL3","ribosomal protein L3","Nucleus","other","Omacetaxine mepesuccinate"]
[0.605,"P22102","GART","phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase","Cytoplasm","enzyme","Pemetrexed disodium",0.522,"P26358","DNMT1","DNA methyltransferase 1","Nucleus","enzyme","Azacitidine;Decitabine","-0.603;-0.92","P04150","NR3C1","nuclear receptor subfamily 3 group C member 1","Nucleus","ligand-dependent nuclear receptor","Fluoxymesterone",0.698,"P23921","RRM1","ribonucleotide reductase catalytic subunit M1","Nucleus","enzyme","Gemcitabine, Hydroxyurea"]
[0.321,"P28074","PSMB5","proteasome 20S subunit beta 5","Cytoplasm","peptidase","Bortezomib;Carfilzomib",-0.575,"Q9UBN7","HDAC6","histone deacetylase 6","Nucleus","transcription regulator","Vorinostat;Romidepsin;Belinostat","-1.49;-1.47","P68366","TUBA4A","tubulin alpha 4a","Cytoplasm","other","Vincristine sulfate;Paclitaxel;Docetaxel;Cabazitaxel;Eribulin mesylate"]
[0.302,"P49721","PSMB2","proteasome 20S subunit beta 2","Cytoplasm","peptidase","Bortezomib;Carfilzomib",-0.579,"P36507","MAP2K2","mitogen-activated protein kinase kinase 2","Cytoplasm","kinase","Trametinib"]
[-0.441,"P00533","EGFR","epidermal growth factor receptor","Plasma Membrane","kinase","Gefitinib;Cetuximab;Erlotinib hydrochloride;Panitumumab;Lapatinib ditosylate;Vandetanib;Afatinib"]
[-0.502,"P04626","ERBB2","erb-b2 receptor tyrosine kinase 2","Plasma Membrane","kinase","Trastuzumab;Lapatinib ditosylate;Pertuzumab;Ado-trastuzumab emtansine;Afatinib"]
[-0.962,"P19793","RXRA","retinoid X receptor alpha","Nucleus","ligand-dependent nuclear receptor","Alitretinoin;Bexarotene"]