region.id somascan.id target locus.protein signal.locus markername rsid cis.trans chr position ea nea eaf effect se p.value targetfullname ensembl.id.protein hgnc.symbol.protein vep.consequence.pqtl r2.ld.proxy rsid.ld.proxy ensembl.id.ld.proxy hgnc.symbol.ld.proxy vep.consequence.ld.proxy ensembl.candidate.gene.1 ensembl.candidate.gene.2 hgnc.candidate.gene candidate.gene.score pqtl.described pqtl.classification effect.olink se.olink p.value.olink replicated.olink olink_assay olink_panel updated_symbol gene_chr gene_start gene_end gene_orientation gene_entrez gene_type snp_hg38 dist 1_1_1 SeqId_14151_4 'UCRP chr1:948870_C_G$SeqId_14151_4 1 chr1:948870_C_G rs4615788 cis 1 948870 C G 0.0397 -1.2085 0.0339 1.4e-277 'Ubiquitin-like protein ISG15 ENSG00000187608 'ISG15 5_prime_UTR_variant ENSG00000187608 ENSG00000187608 'ISG15 3 known specific_protein ISG15 chr1 1001138 1014540 1 9636 protein_coding 1:1013490 12352 1_1_2 SeqId_15483_377 'Agrin chr1:961464_G_T$SeqId_15483_377 1 chr1:961464_G_T rs3128125 cis 1 961464 T G 0.3455 -0.3222 0.0145 9.84e-109 'Agrin ENSG00000188157 'AGRN intron_variant ENSG00000188157 ENSG00000188157 'AGRN 3 known suggestive_specific_pathway AGRN chr1 1020120 1056118 1 375790 protein_coding 1:1026084 5964 1_1_3 SeqId_7981_230 'B3GT6 chr1:1164749_D_I$SeqId_7981_230 1 chr1:1164749_D_I rs113272753 cis 1 1164749 D I 0.8607 0.1971 0.0205 7.96e-22 'Beta-1,3-galactosyltransferase 6 ENSG00000176022 'B3GALT6 intron_variant 0.111454 rs12085009 ENSG00000176022 'B3GALT6 missense_variant ENSG00000176022 ENSG00000176022 'B3GALT6 3 known specific_protein B3GALT6 chr1 1232237 1235041 1 126792 protein_coding 1:1229370 2867 1_1_4 SeqId_10521_10 'MXRA8 chr1:1261824_C_G$SeqId_10521_10 1 chr1:1261824_C_G rs307348 cis 1 1261824 C G 0.9349 0.2502 0.0269 1.36e-20 'Matrix-remodeling-associated protein 8 ENSG00000162576 'MXRA8 intron_variant 0.27101 rs181929025 ENSG00000162576 'MXRA8 missense_variant ENSG00000162576 ENSG00000162576 'MXRA8 3 known specific_protein MXRA8 chr1 1352689 1361777 -1 54587 protein_coding 1:1326444 35333 1_1_5 SeqId_6385_63 'VWA1 chr1:1369623_A_G$SeqId_6385_63 1 chr1:1369623_A_G rs115503338 cis 1 1369623 A G 0.0114 -1.6311 0.0677 2.14e-128 'von Willebrand factor A domain-containing protein 1 ENSG00000179403 'VWA1 upstream_gene_variant ENSG00000179403 ENSG00000179403 'VWA1 3 novel specific_protein VWA1 chr1 1434861 1442882 1 64856 protein_coding 1:1434243 618 1_1_6 SeqId_13624_17 'NADK chr1:1695462_A_C$SeqId_13624_17 1 chr1:1695462_A_C rs4648629 cis 1 1695462 A C 0.4312 -0.2075 0.0135 4.53e-53 'NAD kinase ENSG00000008130 'NADK intron_variant 0.962279 rs4751 ENSG00000008130 'NADK missense_variant ENSG00000008130 ENSG00000008130 'NADK 3 known specific_protein -0.15548 0.059301 0.00901986422073745 yes NADK Olink METABOLISM(v.3402) NADK chr1 1751232 1780457 -1 65220 protein_coding 1:1764023 16434 10_1_1 SeqId_6223_5 'GUC2B chr1:42619139_A_G$SeqId_6223_5 1 chr1:42619139_A_G rs1047047 cis 1 42619139 A G 0.8442 -0.165 0.0185 4.07e-19 'Guanylate cyclase activator 2B ENSG00000044012 'GUCA2B synonymous_variant ENSG00000044012 ENSG00000044012 'GUCA2B 3 known specific_protein GUCA2B chr1 42153410 42155820 1 2981 protein_coding 1:42153468 58 10_1_2 SeqId_17843_30 'PPCS chr1:42903360_A_T$SeqId_17843_30 1 chr1:42903360_A_T rs11210644 cis 1 42903360 A T 0.365 -0.1744 0.0131 2.12e-40 'Phosphopantothenate--cysteine ligase ENSG00000127125 'PPCS intron_variant ENSG00000127125 ENSG00000127125 'PPCS 3 novel specific_protein PPCS chr1 42456117 42473385 1 79717 protein_coding 1:42437689 18428 10_2_1 SeqId_2844_53 'sTie-1 chr1:43779564_C_T$SeqId_2844_53 1 chr1:43779564_C_T rs3120276 cis 1 43779564 T C 0.3903 -0.2584 0.0133 1.52e-83 'Tyrosine-protein kinase receptor Tie-1, soluble ENSG00000066056 'TIE1 synonymous_variant ENSG00000066056 ENSG00000066056 'TIE1 3 known specific_protein -0.15906 0.064071 0.0133813521515402 yes TIE1 Olink CARDIOMETABOLIC(v.3602) TIE1 chr1 43300982 43323108 1 7075 protein_coding 1:43313893 12911 10_2_2 SeqId_3473_78 'Thrombopoietin Receptor chr1:43804340_A_G$SeqId_3473_78 1 chr1:43804340_A_G rs12731981 cis 1 43804340 A G 0.0358 -0.3054 0.0343 5.8e-19 'Thrombopoietin Receptor ENSG00000117400 'MPL missense_variant ENSG00000117400 ENSG00000117400 'MPL 3 novel specific_protein MPL chr1 43337818 43354466 1 4352 protein_coding 1:43338669 851 10_2_4 SeqId_9595_11 'B4GT2 chr1:44445667_C_T$SeqId_9595_11 1 chr1:44445667_C_T rs3762423 cis 1 44445667 T C 0.9445 0.7063 0.0282 4.51e-138 'Beta-1,4-galactosyltransferase 2 ENSG00000117411 'B4GALT2 5_prime_UTR_variant 0.988314 rs1859728 ENSG00000117411 'B4GALT2 missense_variant ENSG00000117411 ENSG00000117411 'B4GALT2 3 known specific_protein B4GALT2 chr1 43978943 43991170 1 8704 protein_coding 1:43979995 1052 10_3_1 SeqId_19289_29 'DCUP chr1:45468606_A_G$SeqId_19289_29 1 chr1:45468606_A_G rs8681 cis 1 45468606 A G 0.2484 -0.4926 0.0149 7.28e-240 'Uroporphyrinogen decarboxylase ENSG00000126088 'UROD 3_prime_UTR_variant ENSG00000126088 ENSG00000126088 'UROD 3 novel specific_protein UROD chr1 45010950 45015575 1 7389 protein_coding 1:45002934 8016 10_3_3 SeqId_3855_56 'Peroxiredoxin-1 chr1:46009316_C_T$SeqId_3855_56 1 chr1:46009316_C_T rs2356552 cis 1 46009316 T C 0.1008 -0.3221 0.022 1.63e-48 'Peroxiredoxin-1 ENSG00000117450 'PRDX1 intergenic_variant ENSG00000117450 ENSG00000117450 'PRDX1 3 novel suggestive_specific_pathway -0.27919 0.1071 0.00942106499588191 yes PRDX1 Olink IMMUNE RESPONSE(v.3202) PRDX1 chr1 45510914 45542732 -1 5052 protein_coding 1:45543644 912 10_3_4 SeqId_4192_10 'AK1A1 chr1:46051053_A_G$SeqId_4192_10 1 chr1:46051053_A_G rs72688441 cis 1 46051053 A G 0.0593 -0.9948 0.0247 1.15e-354 'Alcohol dehydrogenase [NADP(+)] ENSG00000117448 'AKR1A1 intron_variant 0.997949 rs2229540 ENSG00000117448 'AKR1A1 missense_variant ENSG00000117448 ENSG00000117448 'AKR1A1 3 known specific_protein AKR1A1 chr1 45550543 45570049 1 10327 protein_coding 1:45585381 34838 101_1_2 SeqId_6359_50 'AGO61 chr3:43145671_C_T$SeqId_6359_50 1 chr3:43145671_C_T rs4683355 cis 3 43145671 T C 0.486 -0.4338 0.0127 2.27e-257 'Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2 ENSG00000144647 'POMGNT2 intron_variant ENSG00000144647 ENSG00000144647 'POMGNT2 3 known specific_protein POMGNT2 chr3 43079229 43106085 -1 84892 protein_coding 3:43104179 1906 102_1_2 SeqId_5701_81 'Tetranectin chr3:45083928_C_T$SeqId_5701_81 1 chr3:45083928_C_T rs10514712 cis 3 45083928 T C 0.7794 0.2761 0.0161 4.83e-66 'Tetranectin ENSG00000163815 'CLEC3B regulatory_region_variant 0.179731 rs13963 ENSG00000163815 'CLEC3B missense_variant ENSG00000163815 ENSG00000163815 'CLEC3B 3 known suggestive_specific_pathway CLEC3B chr3 45001548 45036071 1 7123 protein_coding 3:45042436 40888 102_2_3 SeqId_16818_200 'CDCP1 chr3:45188535_A_T$SeqId_16818_200 1 chr3:45188535_A_T rs28364749 cis 3 45188535 A T 0.1695 -0.2697 0.0162 1.38e-62 'CUB domain-containing protein 1 ENSG00000163814 'CDCP1 upstream_gene_variant ENSG00000163814 ENSG00000163814 'CDCP1 3 known specific_protein -0.18769 0.06952 0.00718290297296526 yes CDCP1 Olink INFLAMMATION(v.3012) CDCP1 chr3 45082277 45146422 -1 64866 protein_coding 3:45147043 621 102_2_6 SeqId_2780_35 'Lactoferrin chr3:46501284_D_I$SeqId_2780_35 1 chr3:46501284_D_I rs10662431 cis 3 46501284 D I 0.0361 0.7019 0.0396 2.05e-70 'Lactotransferrin ENSG00000012223 'LTF inframe_deletion ENSG00000012223 ENSG00000012223 'LTF 3 novel unspecific_effect LTF chr3 46435645 46485234 -1 4057 protein_coding 3:46459795 25439 102_2_7 SeqId_5810_25 'Cripto chr3:46619238_A_T$SeqId_5810_25 1 chr3:46619238_A_T rs112481213 cis 3 46619238 A T 0.2489 1.3106 0.0094 3.38e-4224 'Teratocarcinoma-derived growth factor 1 ENSG00000241186 'TDGF1 5_prime_UTR_variant 0.278713 rs11130097 ENSG00000241186 'TDGF1 missense_variant ENSG00000241186 ENSG00000241186 'TDGF1 3 known specific_protein 1.3032 0.043624 6.45654229034659e-112 yes TDGF1 chr3 46574534 46582457 1 6997 protein_coding 3:46577748 3214 102_3_1 SeqId_7145_1 'ITIH3 chr3:47283149_D_I$SeqId_7145_1 1 chr3:47283149_D_I rs141584824 trans 3 47283149 D I 0.6073 -0.1046 0.013 9.55e-16 'Inter-alpha-trypsin inhibitor heavy chain H3 ENSG00000162267 'ITIH3 intron_variant 0.93246 rs2276853 ENSG00000088727 'KIF9 missense_variant ENSG00000088727 ENSG00000088727 'KIF9 3 known unspecific_effect ITIH3 chr3 52794768 52809009 1 3699 protein_coding 3:47241660 5553108 102_3_2 SeqId_15481_45 'LL-37 chr3:47045846_C_T$SeqId_15481_45 1 chr3:47045846_C_T rs2305637 trans 3 47045846 T C 0.1766 0.1369 0.0185 1.18e-13 'Antibacterial protein LL-37 ENSG00000164047 'CAMP missense_variant ENSG00000160796 ENSG00000160796 'NBEAL2 3 known unspecific_effect CAMP chr3 48223347 48225491 1 820 protein_coding 3:47004356 1218991 102_3_2 SeqId_9384_17 'Cathelicidin peptide chr3:47097985_A_G$SeqId_9384_17 1 chr3:47097985_A_G rs62246406 trans 3 47097985 A G 0.1764 0.1386 0.0185 7.84e-14 'Cathelicidin antimicrobial peptide ENSG00000164047 'CAMP intron_variant 0.997302 rs2305637 ENSG00000160796 'NBEAL2 missense_variant ENSG00000160796 ENSG00000160796 'NBEAL2 3 known unspecific_effect CAMP chr3 48223347 48225491 1 820 protein_coding 3:47056495 1166852 102_4_1 SeqId_7955_195 'ITI heavy chain H1 chr3:48658467_A_C$SeqId_7955_195 1 chr3:48658467_A_C rs3895736 trans 3 48658467 A C 0.1776 0.1253 0.0178 1.76e-12 'Inter-alpha-trypsin inhibitor heavy chain H1 ENSG00000055957 'ITIH1 splice_region_variant 0.444283 rs13324142 ENSG00000225697 'SLC26A6 missense_variant ENSG00000183396 ENSG00000114302|ENSG00000183396 'PRKAR2A|TMEM89 1 known unspecific_effect ITIH1 chr3 52777595 52792068 1 3697 protein_coding 3:48621034 4156561 102_5_1 SeqId_4407_10 'MSP chr3:49712297_C_T$SeqId_4407_10 1 chr3:49712297_C_T rs11130213 cis 3 49712297 T C 0.2979 -1.225 0.009 7.04e-4026 'Hepatocyte growth factor-like protein ENSG00000173531 'MST1 intron_variant 0.95056 rs3197999 ENSG00000173531 'MST1 missense_variant ENSG00000173531 ENSG00000173531 'MST1 6 known unspecific_effect MST1 chr3 49683947 49689501 -1 4485 protein_coding 3:49674864 14637 102_5_5 SeqId_8309_12 'HYAL1 chr3:50339622_C_T$SeqId_8309_12 1 chr3:50339622_C_T rs116482870 cis 3 50339622 T C 0.0644 -0.2821 0.0272 2.92e-25 'Hyaluronidase-1 ENSG00000114378 'HYAL1 missense_variant ENSG00000114378 ENSG00000114378 'HYAL1 3 known unspecific_effect HYAL1 chr3 50299890 50312381 -1 3373 protein_coding 3:50302191 10190 102_5_6 SeqId_9223_11 'ARMET chr3:51408051_C_T$SeqId_9223_11 1 chr3:51408051_C_T rs1552074 cis 3 51408051 T C 0.8548 0.1434 0.0173 1.2e-16 'Mesencephalic astrocyte-derived neurotrophic factor ENSG00000145050 'MANF intron_variant ENSG00000145050 ENSG00000145050 'MANF 3 known unspecific_effect MANF chr3 51385291 51389397 1 7873 protein_coding 3:51370620 14671 102_6_1 SeqId_7955_195 'ITI heavy chain H1 chr3:52821177_A_C$SeqId_7955_195 1 chr3:52821177_A_C rs2286798 cis 3 52821177 A C 0.6369 0.7502 0.0119 1.24e-865 'Inter-alpha-trypsin inhibitor heavy chain H1 ENSG00000055957 'ITIH1 intron_variant 0.984938 rs678 ENSG00000055957 'ITIH1 missense_variant ENSG00000055957 ENSG00000055957 'ITIH1 6 known unspecific_effect ITIH1 chr3 52777595 52792068 1 3697 protein_coding 3:52787161 9566 102_6_4 SeqId_4811_33 'ITI heavy chain H4 chr3:52848207_C_T$SeqId_4811_33 1 chr3:52848207_C_T rs77347777 cis 3 52848207 T C 0.1155 -0.3038 0.021 1.88e-47 'Inter-alpha-trypsin inhibitor heavy chain H4 ENSG00000055955 'ITIH4 intron_variant 0.115841 rs79186892 ENSG00000248487 'ABHD14A missense_variant ENSG00000055955 ENSG00000055955 'ITIH4 6 novel unspecific_effect ITIH4 chr3 52812962 52830688 -1 3700 protein_coding 3:52814191 16497 102_6_5 SeqId_7145_1 'ITIH3 chr3:52833219_A_G$SeqId_7145_1 1 chr3:52833219_A_G rs2535629 cis 3 52833219 A G 0.335 0.5618 0.0122 5.91e-463 'Inter-alpha-trypsin inhibitor heavy chain H3 ENSG00000162267 'ITIH3 intron_variant 0.598783 rs3617 ENSG00000162267 'ITIH3 missense_variant ENSG00000162267 ENSG00000162267 'ITIH3 4 known unspecific_effect ITIH3 chr3 52794768 52809009 1 3699 protein_coding 3:52799203 4435 102_6_7 SeqId_12738_43 'NISCH chr3:52501451_G_T$SeqId_12738_43 1 chr3:52501451_G_T rs2159607 cis 3 52501451 T G 0.8181 0.1379 0.0171 8.71e-16 'Nischarin ENSG00000010322 'NISCH intron_variant 0.950308 rs887515 ENSG00000010322 'NISCH missense_variant ENSG00000010322 ENSG00000010319|ENSG00000010322 'NISCH|SEMA3G 3 known unspecific_effect NISCH chr3 52455118 52493068 1 11188 protein_coding 3:52467435 12317 102_6_7 SeqId_5628_21 'SEM3G chr3:52477080_C_T$SeqId_5628_21 1 chr3:52477080_C_T rs2016575 cis 3 52477080 T C 0.1765 0.3821 0.0174 4.41e-107 'Semaphorin-3G ENSG00000010319 'SEMA3G intron_variant ENSG00000010319 ENSG00000010319|ENSG00000010322 'NISCH|SEMA3G 3 known unspecific_effect SEMA3G chr3 52433035 52445103 -1 56920 protein_coding 3:52443064 2039 102_6_8 SeqId_3343_1 'Aminoacylase-1 chr3:52016836_C_T$SeqId_3343_1 1 chr3:52016836_C_T rs150416778 cis 3 52016836 T C 0.0192 -0.5904 0.0522 1.22e-29 'Aminoacylase-1 ENSG00000243989 'ACY1 intron_variant 0.290605 rs121912698 ENSG00000243989 'ACY1 missense_variant ENSG00000243989 ENSG00000243989 'ACY1 3 novel specific_protein ACY1 chr3 51983340 51989197 1 95 protein_coding 3:51982820 520 102_7_1 SeqId_8885_6 'CA2D3 chr3:54157059_C_G$SeqId_8885_6 1 chr3:54157059_C_G rs9878608 cis 3 54157059 C G 0.5964 -0.1876 0.0133 7.34e-45 'Voltage-dependent calcium channel subunit alpha-2/delta-3 ENSG00000157445 'CACNA2D3 intron_variant ENSG00000157445 ENSG00000157445 'CACNA2D3 3 known specific_protein CACNA2D3 chr3 54122547 55074557 1 55799 protein_coding 3:54123032 485 103_1_1 SeqId_10001_7 'c-Raf chr3:56849749_C_T$SeqId_10001_7 1 chr3:56849749_C_T rs1354034 trans 3 56849749 T C 0.3998 -0.1126 0.0129 3.36e-18 'RAF proto-oncogene serine/threonine-protein kinase ENSG00000132155 'RAF1 intron_variant ENSG00000144730 ENSG00000163947|ENSG00000168374 'ARF4|ARHGEF3 3 known unspecific_effect RAF1 chr3 12582101 12664201 -1 5894 protein_coding 3:56815721 44151520 103_1_1 SeqId_10490_3 'RPN1 chr3:56849749_C_T$SeqId_10490_3 1 chr3:56849749_C_T rs1354034 trans 3 56849749 T C 0.3999 -0.1474 0.0135 9.61e-28 'Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 ENSG00000163902 'RPN1 intron_variant ENSG00000163947|ENSG00000239388 ENSG00000163947|ENSG00000168374 'ARF4|ARHGEF3 3 known unspecific_effect RPN1 chr3 128619969 128681075 -1 6184 protein_coding 3:56815721 71865354 103_1_1 SeqId_11355_10 'IF5A2 chr3:56849749_C_T$SeqId_11355_10 1 chr3:56849749_C_T rs1354034 trans 3 56849749 T C 0.3997 -0.0941 0.0127 1.13e-13 'Eukaryotic translation initiation factor 5A-2 ENSG00000163577 'EIF5A2 intron_variant ENSG00000163947 ENSG00000163947|ENSG00000168374 'ARF4|ARHGEF3 3 known unspecific_effect EIF5A2 chr3 170888418 170908644 -1 56648 protein_coding 3:56815721 114092923 103_1_1 SeqId_11643_73 'DTX3L chr3:56849749_C_T$SeqId_11643_73 1 chr3:56849749_C_T rs1354034 trans 3 56849749 T C 0.3998 -0.1062 0.0129 1.95e-16 'E3 ubiquitin-protein ligase DTX3L ENSG00000163840 'DTX3L intron_variant ENSG00000239388 ENSG00000163947|ENSG00000168374 'ARF4|ARHGEF3 3 known unspecific_effect DTX3L chr3 122564338 122575203 1 151636 protein_coding 3:56815721 65748617 103_1_1 SeqId_12399_194 'CCD50 chr3:56849749_C_T$SeqId_12399_194 1 chr3:56849749_C_T rs1354034 trans 3 56849749 T C 0.3997 -0.1371 0.0128 7.34e-27 'Coiled-coil domain-containing protein 50 ENSG00000152492 'CCDC50 intron_variant ENSG00000163947 ENSG00000163947|ENSG00000168374 'ARF4|ARHGEF3 3 known unspecific_effect CCDC50 chr3 191329085 191398659 1 152137 protein_coding 3:56815721 134513364 103_1_1 SeqId_12518_289 'PB1 chr3:56849749_C_T$SeqId_12518_289 1 chr3:56849749_C_T rs1354034 trans 3 56849749 T C 0.3996 -0.1291 0.0129 1.26e-23 'Protein polybromo-1 ENSG00000163939 'PBRM1 intron_variant ENSG00000163947 ENSG00000163947|ENSG00000168374 'ARF4|ARHGEF3 3 known unspecific_effect PBRM1 chr3 52545352 52685917 -1 55193 protein_coding 3:56815721 4129804 103_1_1 SeqId_12701_1 'EIF1B chr3:56849749_C_T$SeqId_12701_1 1 chr3:56849749_C_T rs1354034 trans 3 56849749 T C 0.3997 -0.1152 0.0129 3.35e-19 'Eukaryotic translation initiation factor 1b ENSG00000114784 'EIF1B intron_variant ENSG00000163947|ENSG00000163681|ENSG00000239388 ENSG00000163947|ENSG00000168374 'ARF4|ARHGEF3 3 known unspecific_effect EIF1B chr3 40309707 40312424 1 10289 protein_coding 3:56815721 16506014 103_1_1 SeqId_13076_4 'FXR1 chr3:56849749_C_T$SeqId_13076_4 1 chr3:56849749_C_T rs1354034 trans 3 56849749 T C 0.3998 -0.1567 0.0131 8.04e-33 'Fragile X mental retardation syndrome-related protein 1 ENSG00000114416 'FXR1 intron_variant ENSG00000163947|ENSG00000144730|ENSG00000239388 ENSG00000163947|ENSG00000168374 'ARF4|ARHGEF3 3 known unspecific_effect FXR1 chr3 180868141 180982753 1 8087 protein_coding 3:56815721 124052420 103_1_1 SeqId_13713_164 'SC22A chr3:56849749_C_T$SeqId_13713_164 1 chr3:56849749_C_T rs1354034 trans 3 56849749 T C 0.3998 -0.1152 0.013 7.15e-19 'Vesicle-trafficking protein SEC22a ENSG00000121542 'SEC22A intron_variant ENSG00000163947|ENSG00000168374 ENSG00000163947|ENSG00000168374 'ARF4|ARHGEF3 3 known unspecific_effect SEC22A chr3 123201927 123274136 1 26984 protein_coding 3:56815721 66386206 103_1_1 SeqId_14271_23 'RAB6B chr3:56849749_C_T$SeqId_14271_23 1 chr3:56849749_C_T rs1354034 trans 3 56849749 T C 0.3997 -0.1063 0.0129 2.01e-16 'Ras-related protein Rab-6B ENSG00000154917 'RAB6B intron_variant ENSG00000163947|ENSG00000157500|ENSG00000168374|ENSG00000174839|ENSG00000174844 ENSG00000163947|ENSG00000168374 'ARF4|ARHGEF3 3 known unspecific_effect RAB6B chr3 133824235 133895882 -1 51560 protein_coding 3:56815721 77080161 103_1_1 SeqId_14326_4 'UB2E1 chr3:56849749_C_T$SeqId_14326_4 1 chr3:56849749_C_T rs1354034 trans 3 56849749 T C 0.3995 -0.3222 0.0125 5.54e-147 'Ubiquitin-conjugating enzyme E2 E1 ENSG00000170142 'UBE2E1 intron_variant ENSG00000239388 ENSG00000163947|ENSG00000168374 'ARF4|ARHGEF3 3 known unspecific_effect UBE2E1 chr3 23805955 23891640 1 7324 protein_coding 3:56815721 33009766 103_1_1 SeqId_16594_44 'FAIM1 chr3:56849749_C_T$SeqId_16594_44 1 chr3:56849749_C_T rs1354034 trans 3 56849749 T C 0.3999 -0.1043 0.0137 3.17e-14 'Fas apoptotic inhibitory molecule 1 ENSG00000158234 'FAIM intron_variant ENSG00000163947 ENSG00000163947|ENSG00000168374 'ARF4|ARHGEF3 3 known unspecific_effect FAIM chr3 138608606 138633376 1 55179 protein_coding 3:56815721 81792885 103_1_1 SeqId_17205_21 'RAB5A chr3:56849749_C_T$SeqId_17205_21 1 chr3:56849749_C_T rs1354034 trans 3 56849749 T C 0.3997 -0.1089 0.0129 2.82e-17 'Ras-related protein Rab-5A ENSG00000144566 'RAB5A intron_variant ENSG00000157500 ENSG00000163947|ENSG00000168374 'ARF4|ARHGEF3 3 known unspecific_effect RAB5A chr3 19947097 19985175 1 5868 protein_coding 3:56815721 36868624 103_1_1 SeqId_17350_13 'CHM2B chr3:56849749_C_T$SeqId_17350_13 1 chr3:56849749_C_T rs1354034 trans 3 56849749 T C 0.3997 -0.091 0.0129 1.69e-12 'Charged multivesicular body protein 2b ENSG00000083937 'CHMP2B intron_variant ENSG00000163947|ENSG00000239388 ENSG00000163947|ENSG00000168374 'ARF4|ARHGEF3 3 known unspecific_effect CHMP2B chr3 87227271 87255556 1 25978 protein_coding 3:56815721 30411550 103_1_1 SeqId_18184_28 'GUAA chr3:56849749_C_T$SeqId_18184_28 1 chr3:56849749_C_T rs1354034 trans 3 56849749 T C 0.3998 -0.13 0.0131 4.64e-23 'GMP synthase [glutamine-hydrolyzing] ENSG00000163655 'GMPS intron_variant ENSG00000163947 ENSG00000163947|ENSG00000168374 'ARF4|ARHGEF3 3 known unspecific_effect GMPS chr3 155870650 155944020 1 8833 protein_coding 3:56815721 99054929 103_1_1 SeqId_18315_38 'RTP4 chr3:56849749_C_T$SeqId_18315_38 1 chr3:56849749_C_T rs1354034 trans 3 56849749 T C 0.3998 -0.1175 0.0131 3.37e-19 'Receptor-transporting protein 4 ENSG00000136514 'RTP4 intron_variant ENSG00000163947|ENSG00000239388 ENSG00000163947|ENSG00000168374 'ARF4|ARHGEF3 3 known unspecific_effect RTP4 chr3 187368385 187372076 1 64108 protein_coding 3:56815721 130552664 103_1_1 SeqId_18408_26 'ARF4 chr3:56849749_C_T$SeqId_18408_26 1 chr3:56849749_C_T rs1354034 trans 3 56849749 T C 0.3998 -0.1203 0.0131 4.73e-20 'ADP-ribosylation factor 4 ENSG00000168374 'ARF4 intron_variant ENSG00000168374 ENSG00000163947|ENSG00000168374 'ARF4|ARHGEF3 3 known unspecific_effect ARF4 chr3 57571363 57598220 -1 378 protein_coding 3:56815721 782499 103_1_1 SeqId_18415_16 'ARL6 chr3:56849749_C_T$SeqId_18415_16 1 chr3:56849749_C_T rs1354034 trans 3 56849749 T C 0.3996 -0.091 0.0126 4.56e-13 'ADP-ribosylation factor-like protein 6 ENSG00000113966 'ARL6 intron_variant ENSG00000163947 ENSG00000163947|ENSG00000168374 'ARF4|ARHGEF3 3 known unspecific_effect ARL6 chr3 97764521 97801229 1 84100 protein_coding 3:56815721 40948800 103_1_1 SeqId_18824_7 'IF4A2 chr3:56849749_C_T$SeqId_18824_7 1 chr3:56849749_C_T rs1354034 trans 3 56849749 T C 0.3997 -0.1088 0.0135 7.63e-16 'Eukaryotic initiation factor 4A-II ENSG00000156976 'EIF4A2 intron_variant ENSG00000163947|ENSG00000174840|ENSG00000239388 ENSG00000163947|ENSG00000168374 'ARF4|ARHGEF3 3 known unspecific_effect EIF4A2 chr3 186783205 186789897 1 1974 protein_coding 3:56815721 129967484 103_1_1 SeqId_19152_4 'IPP2 chr3:56849749_C_T$SeqId_19152_4 1 chr3:56849749_C_T rs1354034 trans 3 56849749 T C 0.3995 -0.1021 0.0127 9.2e-16 'Protein phosphatase inhibitor 2 ENSG00000184203 'PPP1R2 intron_variant ENSG00000163947|ENSG00000163681 ENSG00000163947|ENSG00000168374 'ARF4|ARHGEF3 3 known unspecific_effect PPP1R2 chr3 195514428 195543386 -1 5504 protein_coding 3:56815721 138727665 103_1_1 SeqId_7187_3 'PPM1L chr3:56849749_C_T$SeqId_7187_3 1 chr3:56849749_C_T rs1354034 trans 3 56849749 T C 0.3996 -0.0955 0.0131 3.3e-13 'Protein phosphatase 1L ENSG00000163590 'PPM1L intron_variant ENSG00000163947 ENSG00000163947|ENSG00000168374 'ARF4|ARHGEF3 3 known unspecific_effect PPM1L chr3 160755602 161078902 1 151742 protein_coding 3:56815721 103939881 103_1_1 SeqId_3379_29 'KPCI chr3:56849749_C_T$SeqId_3379_29 1 chr3:56849749_C_T rs1354034 trans 3 56849749 T C 0.3997 -0.1283 0.0129 1.99e-23 'Protein kinase C iota type ENSG00000163558 'PRKCI intron_variant ENSG00000163947 ENSG00000163947|ENSG00000168374 'ARF4|ARHGEF3 3 known unspecific_effect PRKCI chr3 170222424 170305977 1 5584 protein_coding 3:56815721 113406703 103_1_1 SeqId_3390_72 'PIK3CA/PIK3R1 chr3:56849749_C_T$SeqId_3390_72 1 chr3:56849749_C_T rs1354034 trans 3 56849749 T C 0.3997 -0.0998 0.0134 9.54e-14 'PIK3CA/PIK3R1 ENSG00000145675|ENSG00000121879 'PIK3R1|PIK3CA intron_variant ENSG00000163947 ENSG00000163947|ENSG00000168374 'ARF4|ARHGEF3 3 known unspecific_effect PIK3CA chr3 179148114 179240093 1 5290 protein_coding 3:56815721 122332393 103_1_1 SeqId_3441_64 'GSK-3 alpha/beta chr3:56849749_C_T$SeqId_3441_64 1 chr3:56849749_C_T rs1354034 trans 3 56849749 T C 0.3997 -0.0895 0.013 5.41e-12 'Glycogen synthase kinase-3 alpha/beta ENSG00000105723|ENSG00000082701 'GSK3A|GSK3B intron_variant ENSG00000163947|ENSG00000157500|ENSG00000239388 ENSG00000163947|ENSG00000168374 'ARF4|ARHGEF3 3 known unspecific_effect GSK3B chr3 119821321 120094994 -1 2932 protein_coding 3:56815721 63279273 103_1_1 SeqId_3822_54 'MAPKAPK3 chr3:56849749_C_T$SeqId_3822_54 1 chr3:56849749_C_T rs1354034 trans 3 56849749 T C 0.3997 -0.1096 0.0128 1.29e-17 'MAP kinase-activated protein kinase 3 ENSG00000114738 'MAPKAPK3 intron_variant ENSG00000163947 ENSG00000163947|ENSG00000168374 'ARF4|ARHGEF3 3 known unspecific_effect MAPKAPK3 chr3 50611520 50649291 1 7867 protein_coding 3:56815721 6204201 103_1_1 SeqId_3903_49 'Sorting nexin 4 chr3:56849749_C_T$SeqId_3903_49 1 chr3:56849749_C_T rs1354034 trans 3 56849749 T C 0.3996 -0.129 0.0129 2.17e-23 'Sorting nexin-4 ENSG00000114520 'SNX4 intron_variant ENSG00000163947|ENSG00000168374|ENSG00000174844 ENSG00000163947|ENSG00000168374 'ARF4|ARHGEF3 3 known unspecific_effect SNX4 chr3 125446650 125520202 -1 8723 protein_coding 3:56815721 68704481 103_1_1 SeqId_5250_53 'IMDH2 chr3:56849749_C_T$SeqId_5250_53 1 chr3:56849749_C_T rs1354034 trans 3 56849749 T C 0.3997 -0.1685 0.0128 1.45e-39 'Inosine-5'-monophosphate dehydrogenase 2 ENSG00000178035 'IMPDH2 intron_variant ENSG00000163947|ENSG00000239388 ENSG00000163947|ENSG00000168374 'ARF4|ARHGEF3 3 known unspecific_effect IMPDH2 chr3 49024325 49029447 -1 3615 protein_coding 3:56815721 7786274 103_1_1 SeqId_5715_4 'ABHEA chr3:56849749_C_T$SeqId_5715_4 1 chr3:56849749_C_T rs1354034 trans 3 56849749 T C 0.3995 -0.0903 0.0126 6.22e-13 'Protein ABHD14A ENSG00000248487 'ABHD14A intron_variant ENSG00000163947 ENSG00000163947|ENSG00000168374 'ARF4|ARHGEF3 3 known unspecific_effect ABHD14A chr3 51971426 51981196 1 25864 protein_coding 3:56815721 4844295 103_1_1 SeqId_6467_65 'KTEL1 chr3:56849749_C_T$SeqId_6467_65 1 chr3:56849749_C_T rs1354034 trans 3 56849749 T C 0.3997 -0.1099 0.0128 9.82e-18 'Protein O-glucosyltransferase 1 ENSG00000163389 'POGLUT1 intron_variant ENSG00000163947 ENSG00000163947|ENSG00000168374 'ARF4|ARHGEF3 3 known unspecific_effect POGLUT1 chr3 119468963 119494708 1 56983 protein_coding 3:56815721 62653242 103_1_1 SeqId_9826_135 'Fragile histidine triad protein chr3:56849749_C_T$SeqId_9826_135 1 chr3:56849749_C_T rs1354034 trans 3 56849749 T C 0.3997 -0.0919 0.0128 6.76e-13 'Bis(5'-adenosyl)-triphosphatase ENSG00000189283 'FHIT intron_variant ENSG00000163947 ENSG00000163947|ENSG00000168374 'ARF4|ARHGEF3 3 known unspecific_effect FHIT chr3 59747277 61251459 -1 2272 protein_coding 3:56815721 4435738 103_1_1 SeqId_6653_58 'CD47 chr3:56849749_C_T$SeqId_6653_58 1 chr3:56849749_C_T rs1354034 trans 3 56849749 T C 0.3996 -0.1004 0.0128 5.02e-15 'Leukocyte surface antigen CD47 ENSG00000196776 'CD47 intron_variant ENSG00000163947|ENSG00000144730|ENSG00000168374|ENSG00000174839|ENSG00000174844|ENSG00000239388 ENSG00000163947|ENSG00000168374 'ARF4|ARHGEF3 3 known unspecific_effect CD47 chr3 108043091 108091862 -1 961 protein_coding 3:56815721 51276141 103_1_1 SeqId_6923_1 'PLOD2 chr3:56849749_C_T$SeqId_6923_1 1 chr3:56849749_C_T rs1354034 trans 3 56849749 T C 0.3999 -0.1654 0.0134 7.35e-35 'Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 ENSG00000152952 'PLOD2 intron_variant ENSG00000163947 ENSG00000163947|ENSG00000168374 'ARF4|ARHGEF3 3 known unspecific_effect PLOD2 chr3 146069440 146163653 -1 5352 protein_coding 3:56815721 89347932 103_1_1 SeqId_7110_2 'DJB11 chr3:56849749_C_T$SeqId_7110_2 1 chr3:56849749_C_T rs1354034 trans 3 56849749 T C 0.3998 -0.1007 0.0128 4.42e-15 'DnaJ homolog subfamily B member 11 ENSG00000090520 'DNAJB11 intron_variant ENSG00000163947 ENSG00000163947|ENSG00000168374 'ARF4|ARHGEF3 3 known unspecific_effect DNAJB11 chr3 186567403 186585800 1 51726 protein_coding 3:56815721 129751682 103_1_1 SeqId_9223_11 'ARMET chr3:56849749_C_T$SeqId_9223_11 1 chr3:56849749_C_T rs1354034 trans 3 56849749 T C 0.3995 -0.1179 0.0124 1.5e-21 'Mesencephalic astrocyte-derived neurotrophic factor ENSG00000145050 'MANF intron_variant ENSG00000163947 ENSG00000163947|ENSG00000168374 'ARF4|ARHGEF3 3 known unspecific_effect MANF chr3 51385291 51389397 1 7873 protein_coding 3:56815721 5430430 103_1_1 SeqId_9855_10 'Rho A chr3:56849749_C_T$SeqId_9855_10 1 chr3:56849749_C_T rs1354034 trans 3 56849749 T C 0.3995 -0.1053 0.0125 3.9e-17 'Transforming protein RhoA ENSG00000067560 'RHOA intron_variant ENSG00000163947 ENSG00000163947|ENSG00000168374 'ARF4|ARHGEF3 3 known unspecific_effect RHOA chr3 49359139 49412998 -1 387 protein_coding 3:56815721 7402723 103_1_2 SeqId_3376_49 'IL-17 RD chr3:57140794_A_G$SeqId_3376_49 1 chr3:57140794_A_G rs76645245 cis 3 57140794 A G 0.8376 -0.7163 0.0163 8.24e-422 'Interleukin-17 receptor D ENSG00000144730 'IL17RD intron_variant 0.997932 rs17057718 ENSG00000144730 'IL17RD missense_variant ENSG00000144730 ENSG00000144730 'IL17RD 3 known specific_protein IL17RD chr3 57089982 57170306 -1 54756 protein_coding 3:57106766 63540 103_2_4 SeqId_13102_1 'FAM3D chr3:58652970_A_C$SeqId_13102_1 1 chr3:58652970_A_C rs17551388 cis 3 58652970 A C 0.0987 -0.4004 0.0222 1.47e-72 'Protein FAM3D ENSG00000198643 'FAM3D upstream_gene_variant ENSG00000198643 ENSG00000198643 'FAM3D 3 known specific_protein FAM3D chr3 58633946 58666834 -1 131177 protein_coding 3:58667243 409 104_1_1 SeqId_9826_135 'Fragile histidine triad protein chr3:59969336_A_G$SeqId_9826_135 1 chr3:59969336_A_G rs13070475 cis 3 59969336 A G 0.6469 0.1314 0.0131 1.22e-23 'Bis(5'-adenosyl)-triphosphatase ENSG00000189283 'FHIT intron_variant ENSG00000189283 ENSG00000189283 'FHIT 3 novel specific_protein FHIT chr3 59747277 61251459 -1 2272 protein_coding 3:59983610 1267849 105_1_1 SeqId_18831_6 'LRIG1 chr3:66434643_C_T$SeqId_18831_6 1 chr3:66434643_C_T rs2306272 cis 3 66434643 T C 0.7142 0.7865 0.0121 4.38e-920 'Leucine-rich repeats and immunoglobulin-like domains protein 1 ENSG00000144749 'LRIG1 missense_variant ENSG00000144749 ENSG00000144749 'LRIG1 3 known specific_protein 0.73167 0.064084 6.82338694141669e-27 yes LRIG1 Olink METABOLISM(v.3402) LRIG1 chr3 66378797 66501263 -1 26018 protein_coding 3:66384219 117044 106_1_1 SeqId_10754_113 'Prokineticin-2 chr3:71829242_A_G$SeqId_10754_113 1 chr3:71829242_A_G rs7644362 cis 3 71829242 A G 0.8245 -1.0805 0.0142 5.68e-1260 'Prokineticin-2 ENSG00000163421 'PROK2 intron_variant ENSG00000163421 ENSG00000163421 'PROK2 3 known specific_protein PROK2 chr3 71771655 71785206 -1 60675 protein_coding 3:71780091 5115 107_1_1 SeqId_5116_62 'ROBO2 chr3:77671721_A_C$SeqId_5116_62 1 chr3:77671721_A_C rs2272163 cis 3 77671721 A C 0.3964 -0.1107 0.0131 2.77e-17 'Roundabout homolog 2 ENSG00000185008 'ROBO2 intron_variant ENSG00000185008 ENSG00000185008 'ROBO2 3 novel specific_protein ROBO2 chr3 75906695 77649964 1 6092 protein_coding 3:77622570 1715875 108_1_1 SeqId_5740_17 'ROBO1 chr3:78726601_C_T$SeqId_5740_17 1 chr3:78726601_C_T rs13083361 cis 3 78726601 T C 0.2036 0.1345 0.0155 4.6e-18 'Roundabout homolog 1 ENSG00000169855 'ROBO1 intron_variant ENSG00000169855 ENSG00000169855 'ROBO1 3 novel specific_protein ROBO1 chr3 78597239 79767998 -1 6091 protein_coding 3:78677451 1090547 109_1_1 SeqId_17350_13 'CHM2B chr3:87318758_C_T$SeqId_17350_13 1 chr3:87318758_C_T rs9822911 cis 3 87318758 T C 0.5895 -0.3458 0.0124 6.61e-170 'Charged multivesicular body protein 2b ENSG00000083937 'CHMP2B intron_variant ENSG00000083937 ENSG00000083937 'CHMP2B 3 novel specific_protein CHMP2B chr3 87227271 87255556 1 25978 protein_coding 3:87269608 42337 11_1_1 SeqId_3323_37 'LRP8 chr1:53722752_A_C$SeqId_3323_37 1 chr1:53722752_A_C rs2297663 cis 1 53722752 A C 0.5892 -0.1971 0.0135 4.85e-48 'Low-density lipoprotein receptor-related protein 8 ENSG00000157193 'LRP8 intron_variant ENSG00000157193 ENSG00000157193 'LRP8 5 novel suggestive_specific_pathway LRP8 chr1 53242364 53328469 -1 7804 protein_coding 1:53257080 71389 11_1_2 SeqId_19334_62 'TXD12 chr1:53030028_C_T$SeqId_19334_62 1 chr1:53030028_C_T rs78788484 trans 1 53030028 T C 0.9312 0.2389 0.0255 6.19e-21 'Thioredoxin domain-containing protein 12 ENSG00000117862 'TXNDC12 intergenic_variant 0.381373 rs34521609 ENSG00000085840 'ORC1 missense_variant ENSG00000117862 ENSG00000117862 'TXNDC12 3 novel specific_protein TXNDC12 chr1 52020131 52055191 -1 51060 protein_coding 1:52564356 509165 11_1_3 SeqId_8345_27 'GPX7 chr1:53063559_A_C$SeqId_8345_27 1 chr1:53063559_A_C rs1097234 cis 1 53063559 A C 0.1728 1.0014 0.0139 1.01e-1129 'Glutathione peroxidase 7 ENSG00000116157 'GPX7 upstream_gene_variant ENSG00000116157 ENSG00000116157 'GPX7 3 known specific_protein GPX7 chr1 52602371 52609051 1 2882 protein_coding 1:52597887 4484 11_2_2 SeqId_7856_51 'F151A chr1:55076137_D_I$SeqId_7856_51 1 chr1:55076137_D_I rs373739034 cis 1 55076137 D I 0.0445 -0.6274 0.0345 5.13e-74 'Protein FAM151A ENSG00000162391 'FAM151A stop_gained,frameshift_variant ENSG00000162391 ENSG00000162391 'FAM151A 3 novel specific_protein FAM151A chr1 54609181 54623556 -1 338094 protein_coding 1:54610465 13091 11_2_3 SeqId_5231_79 'PCSK9 chr1:55505647_G_T$SeqId_5231_79 1 chr1:55505647_G_T rs11591147 cis 1 55505647 T G 0.0161 -0.8827 0.0521 2.41e-64 'Proprotein convertase subtilisin/kexin type 9 ENSG00000169174 'PCSK9 missense_variant ENSG00000169174 ENSG00000169174 'PCSK9 3 known specific_protein -1.1534 0.21015 6.55239394015981e-08 yes PCSK9 Olink CARDIOVASCULAR III(v.6112) PCSK9 chr1 55039447 55064852 1 255738 protein_coding 1:55039974 527 110_1_1 SeqId_2700_56 'Protein S chr3:90433267_C_T$SeqId_2700_56 1 chr3:90433267_C_T rs74702263 trans 3 90433267 T C 0.4897 0.1087 0.0135 9.22e-16 'Vitamin K-dependent protein S ENSG00000184500 'PROS1 intergenic_variant 0.276904 rs61739170 ENSG00000178700 'DHFRL1 missense_variant none none ' novel specific_pathway PROS1 chr3 93873051 93980003 -1 5627 protein_coding 3:90384117 3595886 111_1_1 SeqId_2700_56 'Protein S chr3:93580976_G_T$SeqId_2700_56 1 chr3:93580976_G_T rs9290378 cis 3 93580976 T G 0.4055 -0.1249 0.0139 2.3e-19 'Vitamin K-dependent protein S ENSG00000184500 'PROS1 intergenic_variant ENSG00000184500 ENSG00000184500 'PROS1 3 novel specific_pathway PROS1 chr3 93873051 93980003 -1 5627 protein_coding 3:93862132 117871 112_1_1 SeqId_5103_30 'MO2R1 chr3:98383562_A_G$SeqId_5103_30 1 chr3:98383562_A_G rs34211178 trans 3 98383562 A G 0.4511 -0.1219 0.0136 2.53e-19 'Cell surface glycoprotein CD200 receptor 1 ENSG00000163606 'CD200R1 downstream_gene_variant ENSG00000244153 ENSG00000244153 ' 1 known unspecific_effect CD200R1 chr3 112921205 112975103 -1 131450 protein_coding 3:98664718 14310385 112_1_3 SeqId_18241_18 'HEM6 chr3:98386246_A_T$SeqId_18241_18 1 chr3:98386246_A_T rs72928816 cis 3 98386246 A T 0.0104 -0.6418 0.0654 9.39e-23 'Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial ENSG00000080819 'CPOX intergenic_variant 0.859271 rs11921054 ENSG00000080819 'CPOX missense_variant ENSG00000080819 ENSG00000080819 'CPOX 3 novel specific_protein CPOX chr3 98579446 98593648 -1 1371 protein_coding 3:98667402 73754 112_1_5 SeqId_6947_4 'SIA10 chr3:98509705_A_G$SeqId_6947_4 1 chr3:98509705_A_G rs72934623 cis 3 98509705 A G 0.0512 -1.8366 0.0249 4.65e-1184 'Type 2 lactosamine alpha-2,3-sialyltransferase ENSG00000064225 'ST3GAL6 intron_variant 0.998815 rs28489284 ENSG00000064225 'ST3GAL6 missense_variant ENSG00000064225 ENSG00000064225 'ST3GAL6 3 known specific_protein ST3GAL6 chr3 98732236 98821201 1 10402 protein_coding 3:98790861 58625 112_1_6 SeqId_8958_51 'CHL1 chr3:98589868_D_I$SeqId_8958_51 1 chr3:98589868_D_I rs55792662 trans 3 98589868 D I 0.5628 0.1143 0.0137 8.43e-17 'Neural cell adhesion molecule L1-like protein ENSG00000134121 'CHL1 intron_variant ENSG00000057019 ENSG00000057019 'DCBLD2 1 novel unspecific_effect CHL1 chr3 196763 409417 1 10752 protein_coding 3:98871025 98674262 112_2_1 SeqId_17808_37 'NIT2 chr3:100094208_C_T$SeqId_17808_37 1 chr3:100094208_C_T rs13073252 cis 3 100094208 T C 0.3143 -0.1363 0.0136 1.54e-23 'Omega-amidase NIT2 ENSG00000114021 'NIT2 intron_variant ENSG00000114021 ENSG00000114021 'NIT2 3 novel specific_protein NIT2 chr3 100334739 100361635 1 56954 protein_coding 3:100375364 40625 112_3_1 SeqId_17769_28 'PCNP chr3:101345965_A_G$SeqId_17769_28 1 chr3:101345965_A_G rs10936715 cis 3 101345965 A G 0.5086 -0.1526 0.0126 1.39e-33 'PEST proteolytic signal-containing nuclear protein ENSG00000081154 'PCNP downstream_gene_variant ENSG00000081154 ENSG00000081154 'PCNP 3 novel specific_protein PCNP chr3 101574180 101594465 1 57092 protein_coding 3:101627121 52941 113_1_1 SeqId_5451_1 'ALCAM chr3:105063216_A_G$SeqId_5451_1 1 chr3:105063216_A_G rs6437581 cis 3 105063216 A G 0.5589 0.1067 0.0123 4.5e-18 'CD166 antigen ENSG00000170017 'ALCAM intergenic_variant 0.13475 rs1044240 ENSG00000170017 'ALCAM missense_variant ENSG00000170017 ENSG00000170017 'ALCAM 3 known specific_protein 0.087497 0.058535 0.135621954852744 no ALCAM Olink CARDIOVASCULAR III(v.6112) ALCAM chr3 105366909 105576900 1 214 protein_coding 3:105344372 22537 114_1_1 SeqId_17370_186 'ABHDA chr3:111681335_C_T$SeqId_17370_186 1 chr3:111681335_C_T rs698360 cis 3 111681335 T C 0.4763 0.0893 0.0124 5.22e-13 'Mycophenolic acid acyl-glucuronide esterase, mitochondrial ENSG00000144827 'ABHD10 intron_variant ENSG00000144827 ENSG00000144827 'ABHD10 3 novel specific_protein ABHD10 chr3 111979010 111993368 1 55347 protein_coding 3:111962488 16522 114_1_2 SeqId_5112_73 'OX2G chr3:112065028_C_T$SeqId_5112_73 1 chr3:112065028_C_T rs6774405 cis 3 112065028 T C 0.0971 -0.2107 0.0229 3.95e-20 'OX-2 membrane glycoprotein ENSG00000091972 'CD200 intron_variant 0.121099 rs1131199 ENSG00000091972 'CD200 missense_variant ENSG00000091972 ENSG00000091972 'CD200 3 novel specific_protein CD200 chr3 112332347 112362812 1 4345 protein_coding 3:112346181 13834 114_1_3 SeqId_3234_23 'URB chr3:112362188_A_G$SeqId_3234_23 1 chr3:112362188_A_G rs6772337 cis 3 112362188 A G 0.379 0.1218 0.0137 6.49e-19 'Coiled-coil domain-containing protein 80 ENSG00000091986 'CCDC80 upstream_gene_variant ENSG00000091986 ENSG00000091986 'CCDC80 3 known specific_protein 0.077845 0.064707 0.229551428643889 no CCDC80 Olink METABOLISM(v.3402) CCDC80 chr3 112596797 112649530 -1 151887 protein_coding 3:112643341 6189 114_1_4 SeqId_5103_30 'MO2R1 chr3:112554593_C_T$SeqId_5103_30 1 chr3:112554593_C_T rs9847365 cis 3 112554593 T C 0.3525 0.233 0.014 8.54e-62 'Cell surface glycoprotein CD200 receptor 1 ENSG00000163606 'CD200R1 intron_variant 0.494044 rs9865242 ENSG00000163606 'CD200R1 missense_variant ENSG00000163606 ENSG00000163606 'CD200R1 3 known specific_protein -0.17267 0.066464 0.00966718433834455 no CD200R1 Olink NEUROLOGY(v.8011) CD200R1 chr3 112921205 112975103 -1 131450 protein_coding 3:112835746 139357 114_2_1 SeqId_8842_16 'GRM1C chr3:113621837_C_G$SeqId_8842_16 1 chr3:113621837_C_G rs1872823 cis 3 113621837 C G 0.6377 -0.5309 0.0135 3.04e-338 'GRAM domain-containing protein 1C ENSG00000178075 'GRAMD1C intron_variant ENSG00000178075 ENSG00000178075 'GRAMD1C 3 known unspecific_effect GRAMD1C chr3 113828182 113947174 1 54762 protein_coding 3:113902990 74808 114_2_1 SeqId_8336_267 'GRM1C chr3:113621837_C_G$SeqId_8336_267 1 chr3:113621837_C_G rs1872823 cis 3 113621837 C G 0.6377 -0.2733 0.014 2.87e-85 'GRAM domain-containing protein 1C ENSG00000178075 'GRAMD1C intron_variant ENSG00000178075 ENSG00000178075 'GRAMD1C 3 known unspecific_effect GRAMD1C chr3 113828182 113947174 1 54762 protein_coding 3:113902990 74808 114_2_2 SeqId_4328_2 'BOC chr3:113004861_A_G$SeqId_4328_2 1 chr3:113004861_A_G rs34284771 cis 3 113004861 A G 0.8243 -0.2017 0.0166 6.75e-34 'Brother of CDO ENSG00000144857 'BOC intron_variant ENSG00000144857 ENSG00000144857 'BOC 3 known specific_protein -0.21451 0.07543 0.00464729241676204 yes BOC Olink CARDIOVASCULAR II(v.5004) BOC chr3 113211003 113287459 1 91653 protein_coding 3:113286014 75011 115_1_1 SeqId_2999_6 'LSAMP chr3:116106823_C_T$SeqId_2999_6 1 chr3:116106823_C_T rs2116308 cis 3 116106823 T C 0.1727 -0.1653 0.0154 6.03e-27 'Limbic system-associated membrane protein ENSG00000185565 'LSAMP intron_variant ENSG00000185565 ENSG00000185565 'LSAMP 3 known specific_protein LSAMP chr3 115802363 117139389 -1 4045 protein_coding 3:116387976 751413 116_1_1 SeqId_6467_65 'KTEL1 chr3:119136267_C_G$SeqId_6467_65 1 chr3:119136267_C_G rs115630304 cis 3 119136267 C G 0.9346 -0.6972 0.0245 1.99e-177 'Protein O-glucosyltransferase 1 ENSG00000163389 'POGLUT1 3_prime_UTR_variant ENSG00000163389 ENSG00000163389 'POGLUT1 3 known specific_protein POGLUT1 chr3 119468963 119494708 1 56983 protein_coding 3:119417420 51543 116_1_3 SeqId_13112_179 'FSTL1 chr3:120169248_C_T$SeqId_13112_179 1 chr3:120169248_C_T rs1147707 cis 3 120169248 T C 0.3881 -0.3139 0.0138 3.59e-114 'Follistatin-related protein 1 ENSG00000163430 'FSTL1 intron_variant ENSG00000163430 ENSG00000163430 'FSTL1 3 known specific_protein FSTL1 chr3 120392293 120450993 -1 11167 protein_coding 3:120450401 592 116_1_4 SeqId_9832_33 'HGD chr3:120394052_A_T$SeqId_9832_33 1 chr3:120394052_A_T rs2042482 cis 3 120394052 A T 0.2557 -0.2037 0.0146 4.42e-44 'Homogentisate 1,2-dioxygenase ENSG00000113924 'HGD intron_variant 0.992937 rs2255543 ENSG00000113924 'HGD missense_variant ENSG00000113924 ENSG00000113924 'HGD 3 novel specific_protein HGD chr3 120628172 120682269 -1 3081 protein_coding 3:120675205 7064 117_1_1 SeqId_5593_11 'PDIA5 chr3:122833003_C_T$SeqId_5593_11 1 chr3:122833003_C_T rs3804749 cis 3 122833003 T C 0.5884 -0.8741 0.0107 7.15e-1452 'Protein disulfide-isomerase A5 ENSG00000065485 'PDIA5 intron_variant ENSG00000065485 ENSG00000065485 'PDIA5 4 known unspecific_effect PDIA5 chr3 123067025 123225227 1 10954 protein_coding 3:123114156 47131 117_1_2 SeqId_6531_29 'F162A chr3:122125544_C_G$SeqId_6531_29 1 chr3:122125544_C_G rs7615673 cis 3 122125544 C G 0.1611 -0.1828 0.0167 1.01e-27 'Protein FAM162A ENSG00000114023 'FAM162A intron_variant 0.123257 rs140995238 ENSG00000114023 'FAM162A missense_variant ENSG00000114023 ENSG00000114023 'FAM162A 3 novel specific_protein FAM162A chr3 122384161 122412334 1 26355 protein_coding 3:122406697 22536 119_1_1 SeqId_7955_195 'ITI heavy chain H1 chr3:126267107_A_G$SeqId_7955_195 1 chr3:126267107_A_G rs11920905 trans 3 126267107 A G 0.261 0.1931 0.0153 2.02e-36 'Inter-alpha-trypsin inhibitor heavy chain H1 ENSG00000055957 'ITIH1 downstream_gene_variant 0.919699 rs1056523 ENSG00000180767 'CHST13 missense_variant ENSG00000180767 ENSG00000180767 'CHST13 4 known unspecific_effect ITIH1 chr3 52777595 52792068 1 3697 protein_coding 3:126548264 73770669 119_1_2 SeqId_9005_16 'PLXA1 chr3:126717964_A_G$SeqId_9005_16 1 chr3:126717964_A_G rs7644947 cis 3 126717964 A G 0.3045 -0.207 0.0138 1.41e-50 'Plexin-A1 ENSG00000114554 'PLXNA1 intron_variant ENSG00000114554 ENSG00000114554 'PLXNA1 3 known specific_protein PLXNA1 chr3 126982693 127037389 1 5361 protein_coding 3:126999121 16428 119_2_2 SeqId_19561_216 'PLXD1 chr3:129293256_C_T$SeqId_19561_216 1 chr3:129293256_C_T rs2255703 cis 3 129293256 T C 0.6162 0.2362 0.0136 3.1e-67 'Plexin-D1 ENSG00000004399 'PLXND1 missense_variant ENSG00000004399 ENSG00000004399 'PLXND1 3 novel specific_protein PLXND1 chr3 129555214 129606676 -1 23129 protein_coding 3:129574413 32263 12_1_1 SeqId_6606_61 'KISS1 chr1:57403803_C_G$SeqId_6606_61 1 chr1:57403803_C_G rs684216 trans 1 57403803 C G 0.6668 -0.3737 0.0139 3.49e-158 'Metastasis-suppressor KiSS-1 ENSG00000170498 'KISS1 intron_variant 0.17033 rs652785 ENSG00000157131 'C8A missense_variant ENSG00000021852|ENSG00000162409|ENSG00000173406 ENSG00000157131 'C8A 4 known unspecific_effect KISS1 chr1 204190341 204196491 -1 3814 protein_coding 1:56938130 147258361 12_2_2 SeqId_3009_3 'TGF-b R III chr1:59661309_G_T$SeqId_3009_3 1 chr1:59661309_G_T rs7534174 trans 1 59661309 T G 0.7088 -0.1205 0.0147 3.08e-16 'Transforming growth factor beta receptor type 3 ENSG00000069702 'TGFBR3 intron_variant ENSG00000224609|ENSG00000177606 ENSG00000177606|ENSG00000224609 'JUN 1 novel specific_protein TGFBR3 chr1 91680343 91906335 -1 7049 protein_coding 1:59195637 32710698 120_2_1 SeqId_4162_54 'Transferrin chr3:133484712_A_G$SeqId_4162_54 1 chr3:133484712_A_G rs1525892 cis 3 133484712 A G 0.3329 0.1321 0.0141 9.17e-21 'Serotransferrin ENSG00000091513 'TF intron_variant ENSG00000091513 ENSG00000091513 'TF 5 known unspecific_effect TF chr3 133746040 133796641 1 7018 protein_coding 3:133765868 19828 120_2_3 SeqId_14271_23 'RAB6B chr3:133607140_A_G$SeqId_14271_23 1 chr3:133607140_A_G rs10212397 cis 3 133607140 A G 0.1467 -0.4532 0.0174 8.62e-149 'Ras-related protein Rab-6B ENSG00000154917 'RAB6B intron_variant ENSG00000154917 ENSG00000154917 'RAB6B 3 known specific_protein RAB6B chr3 133824235 133895882 -1 51560 protein_coding 3:133888296 7586 120_2_4 SeqId_17680_12 'EPHB1 chr3:134667171_D_I$SeqId_17680_12 1 chr3:134667171_D_I rs34196572 cis 3 134667171 D I 0.5427 -0.2855 0.013 7.51e-107 'Ephrin type-B receptor 1 ENSG00000154928 'EPHB1 intron_variant ENSG00000154928 ENSG00000154928 'EPHB1 3 novel specific_protein EPHB1 chr3 134795260 135260467 1 2047 protein_coding 3:134948330 153070 121_1_1 SeqId_16594_44 'FAIM1 chr3:138347957_A_G$SeqId_16594_44 1 chr3:138347957_A_G rs641320 cis 3 138347957 A G 0.0724 -0.9694 0.0247 6.77e-337 'Fas apoptotic inhibitory molecule 1 ENSG00000158234 'FAIM missense_variant ENSG00000158234 ENSG00000158234 'FAIM 3 known specific_protein FAIM chr3 138608606 138633376 1 55179 protein_coding 3:138629115 20509 121_1_2 SeqId_3390_72 'PIK3CA/PIK3R1 chr3:138487683_A_G$SeqId_3390_72 1 chr3:138487683_A_G rs361071 trans 3 138487683 A G 0.4709 -0.1463 0.0131 7.37e-29 'PIK3CA/PIK3R1 ENSG00000145675|ENSG00000121879 'PIK3R1|PIK3CA intron_variant 0.574275 rs1673607 ENSG00000114107 'CEP70 missense_variant ENSG00000051382 ENSG00000051382 'PIK3CB 3 novel specific_protein PIK3CA chr3 179148114 179240093 1 5290 protein_coding 3:138768841 40379273 121_1_3 SeqId_19279_42 'CRBP chr3:139257603_A_G$SeqId_19279_42 1 chr3:139257603_A_G rs2071387 cis 3 139257603 A G 0.8117 -0.1497 0.017 1.54e-18 'Retinol-binding protein 1 ENSG00000114115 'RBP1 intron_variant 0.322246 rs2071386 ENSG00000114115 'RBP1 missense_variant ENSG00000114115 ENSG00000114115 'RBP1 3 novel specific_protein RBP1 chr3 139517434 139539829 -1 5947 protein_coding 3:139538761 1068 121_1_4 SeqId_18882_7 'CSTN2 chr3:139612665_D_I$SeqId_18882_7 1 chr3:139612665_D_I rs151281776 cis 3 139612665 D I 0.2162 -0.2812 0.0165 1.82e-65 'Calsyntenin-2 ENSG00000158258 'CLSTN2 regulatory_region_variant ENSG00000158258 ENSG00000158258 'CLSTN2 3 novel specific_protein -0.30055 0.076421 9.6272001297332e-05 yes CLSTN2 Olink METABOLISM(v.3402) CLSTN2 chr3 139935185 140577397 1 64084 protein_coding 3:139893824 41361 122_1_1 SeqId_6081_52 'PCOC2 chr3:142605556_A_G$SeqId_6081_52 1 chr3:142605556_A_G rs11716897 cis 3 142605556 A G 0.3448 0.3954 0.0134 3.64e-192 'Procollagen C-endopeptidase enhancer 2 ENSG00000163710 'PCOLCE2 intron_variant ENSG00000163710 ENSG00000163710 'PCOLCE2 3 known specific_protein PCOLCE2 chr3 142815922 142889206 -1 26577 protein_coding 3:142886714 2492 123_1_1 SeqId_6923_1 'PLOD2 chr3:145833232_A_C$SeqId_6923_1 1 chr3:145833232_A_C rs6801418 cis 3 145833232 A C 0.5134 0.2457 0.0129 2.93e-80 'Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 ENSG00000152952 'PLOD2 intron_variant ENSG00000152952 ENSG00000152952 'PLOD2 3 novel specific_protein PLOD2 chr3 146069440 146163653 -1 5352 protein_coding 3:146115445 48208 124_1_1 SeqId_15375_49 'Carboxypeptidase B1 chr3:148558447_A_G$SeqId_15375_49 1 chr3:148558447_A_G rs2291671 cis 3 148558447 A G 0.232 0.278 0.0156 5.25e-71 'Carboxypeptidase B ENSG00000153002 'CPB1 intron_variant 0.997505 rs1059502 ENSG00000153002 'CPB1 missense_variant ENSG00000153002 ENSG00000153002 'CPB1 3 known specific_protein 0.14168 0.072814 0.0522516489016382 no CPB1 Olink CARDIOVASCULAR III(v.6112) CPB1 chr3 148791102 148860187 1 1360 protein_coding 3:148840660 49558 126_1_1 SeqId_8398_277 'RAR-responsive protein TIG1 chr3:158455703_A_C$SeqId_8398_277 1 chr3:158455703_A_C rs61696028 cis 3 158455703 A C 0.8439 -1.398 0.013 4.64e-2514 'Retinoic acid receptor responder protein 1 ENSG00000118849 'RARRES1 upstream_gene_variant 0.816552 rs147016103 ENSG00000118849 'RARRES1 missense_variant ENSG00000118849 ENSG00000118849 'RARRES1 3 known specific_protein -0.15283 0.09234 0.0985598423156596 no RARRES1 Olink ORGAN DAMAGE(v.3301) RARRES1 chr3 158696892 158732489 -1 5918 protein_coding 3:158737914 5425 127_1_1 SeqId_10565_19 'SLIK3 chr3:164911694_G_T$SeqId_10565_19 1 chr3:164911694_G_T rs62282371 cis 3 164911694 T G 0.8672 0.4933 0.0194 3.41e-143 'SLIT and NTRK-like protein 3 ENSG00000121871 'SLITRK3 intron_variant ENSG00000121871 ENSG00000121871 'SLITRK3 3 known specific_protein SLITRK3 chr3 165186720 165197109 -1 22865 protein_coding 3:165193906 3203 127_2_1 SeqId_16299_13 'TIGIT chr3:165435938_C_G$SeqId_16299_13 1 chr3:165435938_C_G rs697356 trans 3 165435938 C G 0.4096 0.0972 0.0139 2.8e-12 'T-cell immunoreceptor with Ig and ITIM domains ENSG00000181847 'TIGIT intergenic_variant 0.338927 rs1803274 ENSG00000114200 'BCHE missense_variant none ENSG00000090402 'SI 1 known unspecific_effect TIGIT chr3 114276913 114310288 1 201633 protein_coding 3:165718150 51441237 127_2_2 SeqId_6447_73 'PTX3 chr3:165489724_C_T$SeqId_6447_73 1 chr3:165489724_C_T rs17713196 trans 3 165489724 T C 0.2054 0.1543 0.0166 1.61e-20 'Pentraxin-related protein PTX3 ENSG00000163661 'PTX3 downstream_gene_variant 0.999658 rs1803274 ENSG00000114200 'BCHE missense_variant ENSG00000114200 ENSG00000114200 'BCHE 8 known unspecific_effect -0.026462 0.076857 0.730768805087065 no PTX3 Olink CARDIOVASCULAR II(v.5004) PTX3 chr3 157436850 157443633 1 5806 protein_coding 3:165771936 8335086 127_2_2 SeqId_10490_3 'RPN1 chr3:165482064_A_G$SeqId_10490_3 1 chr3:165482064_A_G rs62295996 trans 3 165482064 A G 0.2053 -0.1237 0.0163 3.57e-14 'Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 ENSG00000163902 'RPN1 intergenic_variant 1.0 rs1803274 ENSG00000114200 'BCHE missense_variant ENSG00000114200 ENSG00000114200 'BCHE 8 known unspecific_effect RPN1 chr3 128619969 128681075 -1 6184 protein_coding 3:165764276 37083201 127_2_2 SeqId_12420_10 'GPD1L chr3:165482064_A_G$SeqId_12420_10 1 chr3:165482064_A_G rs62295996 trans 3 165482064 A G 0.2053 0.2244 0.0164 2.26e-42 'Glycerol-3-phosphate dehydrogenase 1-like protein ENSG00000152642 'GPD1L intergenic_variant 1.0 rs1803274 ENSG00000114200 'BCHE missense_variant ENSG00000114200 ENSG00000114200 'BCHE 8 known unspecific_effect GPD1L chr3 32105689 32168709 1 23171 protein_coding 3:165764276 133658587 127_2_2 SeqId_12647_52 'SETD2 chr3:165491280_C_T$SeqId_12647_52 1 chr3:165491280_C_T rs1803274 trans 3 165491280 T C 0.2061 -0.1241 0.0172 5.17e-13 'Histone-lysine N-methyltransferase SETD2 ENSG00000181555 'SETD2 missense_variant ENSG00000114200 ENSG00000114200 'BCHE 8 known unspecific_effect SETD2 chr3 47016428 47164113 -1 29072 protein_coding 3:165773492 118609379 127_2_2 SeqId_12825_18 'DP13A chr3:165499135_D_I$SeqId_12825_18 1 chr3:165499135_D_I rs78119247 trans 3 165499135 D I 0.2059 -0.1221 0.0165 1.45e-13 'DCC-interacting protein 13-alpha ENSG00000157500 'APPL1 intron_variant 0.995871 rs1803274 ENSG00000114200 'BCHE missense_variant ENSG00000114200 ENSG00000114200 'BCHE 8 known unspecific_effect APPL1 chr3 57227726 57278105 1 26060 protein_coding 3:165781348 108553622 127_2_2 SeqId_15481_45 'LL-37 chr3:165488604_G_T$SeqId_15481_45 1 chr3:165488604_G_T rs17713088 trans 3 165488604 T G 0.2054 0.1379 0.0166 9.02e-17 'Antibacterial protein LL-37 ENSG00000164047 'CAMP downstream_gene_variant 1.0 rs1803274 ENSG00000114200 'BCHE missense_variant ENSG00000114200 ENSG00000114200 'BCHE 8 known unspecific_effect CAMP chr3 48223347 48225491 1 820 protein_coding 3:165770816 117547469 127_2_2 SeqId_15514_26 'Pseudocholinesterase chr3:165488604_G_T$SeqId_15514_26 1 chr3:165488604_G_T rs17713088 cis 3 165488604 T G 0.2054 -0.6873 0.0146 1.03e-483 'Cholinesterase ENSG00000114200 'BCHE downstream_gene_variant 1.0 rs1803274 ENSG00000114200 'BCHE missense_variant ENSG00000114200 ENSG00000114200 'BCHE 8 known unspecific_effect BCHE chr3 165772904 165837462 -1 590 protein_coding 3:165770816 66646 127_2_2 SeqId_16308_14 'BTLA chr3:165461835_A_G$SeqId_16308_14 1 chr3:165461835_A_G rs1619994 trans 3 165461835 A G 0.6908 -0.1198 0.0145 1.17e-16 'B- and T-lymphocyte attenuator ENSG00000186265 'BTLA intergenic_variant 0.550986 rs1803274 ENSG00000114200 'BCHE missense_variant none ENSG00000114200 'BCHE 8 known unspecific_effect BTLA chr3 112463966 112499472 -1 151888 protein_coding 3:165744047 53244575 127_2_2 SeqId_17453_34 'Ceruloplasmin chr3:165495142_D_I$SeqId_17453_34 1 chr3:165495142_D_I rs71674639 trans 3 165495142 D I 0.2066 0.2067 0.0162 4.28e-37 'Ceruloplasmin ENSG00000047457 'CP intron_variant 0.994482 rs1803274 ENSG00000114200 'BCHE missense_variant ENSG00000114200 ENSG00000114200 'BCHE 8 known unspecific_effect CP chr3 149162410 149221829 -1 1356 protein_coding 3:165777355 16555526 127_2_2 SeqId_17820_170 'MLF1 chr3:165499135_D_I$SeqId_17820_170 1 chr3:165499135_D_I rs78119247 trans 3 165499135 D I 0.2059 0.2041 0.0166 6.02e-35 'Myeloid leukemia factor 1 ENSG00000178053 'MLF1 intron_variant 0.995871 rs1803274 ENSG00000114200 'BCHE missense_variant ENSG00000114200 ENSG00000114200 'BCHE 8 known unspecific_effect MLF1 chr3 158571163 158607252 1 4291 protein_coding 3:165781348 7210185 127_2_2 SeqId_18297_8 'RASM chr3:165499135_D_I$SeqId_18297_8 1 chr3:165499135_D_I rs78119247 trans 3 165499135 D I 0.2059 0.1229 0.0164 7.0e-14 'Ras-related protein M-Ras ENSG00000158186 'MRAS intron_variant 0.995871 rs1803274 ENSG00000114200 'BCHE missense_variant ENSG00000114200 ENSG00000114200 'BCHE 8 known unspecific_effect MRAS chr3 138347648 138405534 1 22808 protein_coding 3:165781348 27433700 127_2_2 SeqId_18408_26 'ARF4 chr3:165489724_C_T$SeqId_18408_26 1 chr3:165489724_C_T rs17713196 trans 3 165489724 T C 0.2054 0.2045 0.0158 2.08e-38 'ADP-ribosylation factor 4 ENSG00000168374 'ARF4 downstream_gene_variant 0.999658 rs1803274 ENSG00000114200 'BCHE missense_variant ENSG00000114200 ENSG00000114200 'BCHE 8 known unspecific_effect ARF4 chr3 57571363 57598220 -1 378 protein_coding 3:165771936 108173716 127_2_2 SeqId_2640_3 'MSP R chr3:165499135_D_I$SeqId_2640_3 1 chr3:165499135_D_I rs78119247 trans 3 165499135 D I 0.2059 0.1386 0.0166 8.35e-17 'Macrophage-stimulating protein receptor ENSG00000164078 'MST1R intron_variant 0.995871 rs1803274 ENSG00000114200 'BCHE missense_variant ENSG00000114200 ENSG00000114200 'BCHE 8 known unspecific_effect MST1R chr3 49887002 49903873 -1 4486 protein_coding 3:165781348 115877475 127_2_2 SeqId_8087_250 'RNF13 chr3:165461954_D_I$SeqId_8087_250 1 chr3:165461954_D_I rs35160503 trans 3 165461954 D I 0.6883 0.0987 0.0144 8.49e-12 'E3 ubiquitin-protein ligase RNF13 ENSG00000082996 'RNF13 intergenic_variant 0.560545 rs1803274 ENSG00000114200 'BCHE missense_variant none ENSG00000114200 'BCHE 8 known unspecific_effect RNF13 chr3 149812770 149962139 1 11342 protein_coding 3:165744167 15931397 127_2_2 SeqId_6994_19 'CC018 chr3:165495142_D_I$SeqId_6994_19 1 chr3:165495142_D_I rs71674639 trans 3 165495142 D I 0.2066 0.2254 0.0166 6.45e-42 'Uncharacterized protein C3orf18 ENSG00000088543 'C3orf18 intron_variant 0.994482 rs1803274 ENSG00000114200 'BCHE missense_variant ENSG00000114200 ENSG00000114200 'BCHE 8 known unspecific_effect C3orf18 chr3 50558025 50571027 -1 51161 protein_coding 3:165777355 115206328 127_2_2 SeqId_8905_20 'KCMB3 chr3:165480100_A_G$SeqId_8905_20 1 chr3:165480100_A_G rs6445035 trans 3 165480100 A G 0.206 0.2045 0.0159 1.15e-37 'Calcium-activated potassium channel subunit beta-3 ENSG00000171121 'KCNMB3 intergenic_variant 0.995906 rs1803274 ENSG00000114200 'BCHE missense_variant ENSG00000114200 ENSG00000114200 'BCHE 8 known unspecific_effect KCNMB3 chr3 179236691 179267002 -1 27094 protein_coding 3:165762312 13504690 127_2_2 SeqId_8424_269 'b-Catenin chr3:165499135_D_I$SeqId_8424_269 1 chr3:165499135_D_I rs78119247 trans 3 165499135 D I 0.2059 0.1711 0.0166 5.15e-25 'Catenin beta-1 ENSG00000168036 'CTNNB1 intron_variant 0.995871 rs1803274 ENSG00000114200 'BCHE missense_variant ENSG00000114200 ENSG00000114200 'BCHE 8 known unspecific_effect CTNNB1 chr3 41194741 41260096 1 1499 protein_coding 3:165781348 124586607 127_2_2 SeqId_9384_17 'Cathelicidin peptide chr3:165488604_G_T$SeqId_9384_17 1 chr3:165488604_G_T rs17713088 trans 3 165488604 T G 0.2054 0.2117 0.0166 2.37e-37 'Cathelicidin antimicrobial peptide ENSG00000164047 'CAMP downstream_gene_variant 1.0 rs1803274 ENSG00000114200 'BCHE missense_variant ENSG00000114200 ENSG00000114200 'BCHE 8 known unspecific_effect CAMP chr3 48223347 48225491 1 820 protein_coding 3:165770816 117547469 127_2_3 SeqId_10677_9 'NDUB4 chr3:165521844_D_I$SeqId_10677_9 1 chr3:165521844_D_I rs11447348 trans 3 165521844 D I 0.3112 0.1407 0.0145 4.05e-22 'NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 ENSG00000065518 'NDUFB4 intron_variant 0.466591 rs1803274 ENSG00000114200 'BCHE missense_variant none ENSG00000114200 'BCHE 3 known unspecific_effect NDUFB4 chr3 120596328 120602507 1 4710 protein_coding 3:165804057 45207729 127_2_3 SeqId_11293_14 'LRRN1 chr3:165488865_C_T$SeqId_11293_14 1 chr3:165488865_C_T rs2686401 trans 3 165488865 T C 0.3687 0.1049 0.0141 8.76e-14 'Leucine-rich repeat neuronal protein 1 ENSG00000175928 'LRRN1 downstream_gene_variant 0.444284 rs1803274 ENSG00000114200 'BCHE missense_variant none ENSG00000114200 'BCHE 3 known unspecific_effect LRRN1 chr3 3799431 3849834 1 57633 protein_coding 3:165771077 161971646 127_2_3 SeqId_13268_45 'WNT5A chr3:165544302_C_G$SeqId_13268_45 1 chr3:165544302_C_G rs2048493 trans 3 165544302 C G 0.6403 -0.1307 0.0138 3.66e-21 'Protein Wnt-5a ENSG00000114251 'WNT5A intron_variant 0.378824 rs1803274 ENSG00000114200 'BCHE missense_variant none ENSG00000114200 'BCHE 3 known unspecific_effect WNT5A chr3 55465715 55490539 -1 7474 protein_coding 3:165826514 110335975 127_2_3 SeqId_4545_53 'DnaJ homolog chr3:165707526_D_I$SeqId_4545_53 1 chr3:165707526_D_I rs141748118 trans 3 165707526 D I 0.2842 -0.0981 0.0141 3.1e-12 'Mitochondrial import inner membrane translocase subunit TIM14 ENSG00000205981 'DNAJC19 intergenic_variant 0.383855 rs1803274 ENSG00000114200 'BCHE missense_variant none ENSG00000114200 'BCHE 3 known unspecific_effect DNAJC19 chr3 180983697 180989774 -1 131118 protein_coding 3:165989739 15000035 127_2_3 SeqId_19587_12 'IMA5 chr3:165521844_D_I$SeqId_19587_12 1 chr3:165521844_D_I rs11447348 trans 3 165521844 D I 0.3112 0.0983 0.0143 7.51e-12 'Importin subunit alpha-5 ENSG00000114030 'KPNA1 intron_variant 0.466591 rs1803274 ENSG00000114200 'BCHE missense_variant none ENSG00000114200 'BCHE 3 known unspecific_effect KPNA1 chr3 122421902 122514945 -1 3836 protein_coding 3:165804057 43289112 127_2_3 SeqId_4436_1 'ENTP3 chr3:165521844_D_I$SeqId_4436_1 1 chr3:165521844_D_I rs11447348 trans 3 165521844 D I 0.3112 0.1135 0.0147 1.36e-14 'Ectonucleoside triphosphate diphosphohydrolase 3 ENSG00000168032 'ENTPD3 intron_variant 0.466591 rs1803274 ENSG00000114200 'BCHE missense_variant none ENSG00000114200 'BCHE 3 known unspecific_effect ENTPD3 chr3 40387184 40428744 1 956 protein_coding 3:165804057 125416873 127_2_3 SeqId_4712_28 'Apo D chr3:165521844_D_I$SeqId_4712_28 1 chr3:165521844_D_I rs11447348 trans 3 165521844 D I 0.3112 0.1184 0.0141 5.72e-17 'Apolipoprotein D ENSG00000189058 'APOD intron_variant 0.466591 rs1803274 ENSG00000114200 'BCHE missense_variant none ENSG00000114200 'BCHE 3 known unspecific_effect APOD chr3 195568705 195584033 -1 347 protein_coding 3:165804057 29779976 127_2_3 SeqId_8690_25 'CAV3 chr3:165706855_A_G$SeqId_8690_25 1 chr3:165706855_A_G rs12491503 trans 3 165706855 A G 0.3384 -0.1094 0.0143 2.33e-14 'Caveolin-3 ENSG00000182533 'CAV3 intergenic_variant 0.318073 rs1803274 ENSG00000114200 'BCHE missense_variant none ENSG00000114200 'BCHE 3 known unspecific_effect CAV3 chr3 8733802 8841808 1 859 protein_coding 3:165989067 157255265 127_2_4 SeqId_17366_6 'DCNL1 chr3:165548529_C_T$SeqId_17366_6 1 chr3:165548529_C_T rs1799807 trans 3 165548529 T C 0.9798 -0.3682 0.0468 3.74e-15 'DCN1-like protein 1 ENSG00000043093 'DCUN1D1 missense_variant ENSG00000114200 ENSG00000114200 'BCHE 3 known unspecific_effect DCUN1D1 chr3 182938074 182985953 -1 54165 protein_coding 3:165830741 17155212 127_2_5 SeqId_5112_73 'OX2G chr3:165567847_A_T$SeqId_5112_73 1 chr3:165567847_A_T rs540274076 trans 3 165567847 A T 0.9183 0.1716 0.0249 5.99e-12 'OX-2 membrane glycoprotein ENSG00000091972 'CD200 intergenic_variant 0.317266 rs1803274 ENSG00000114200 'BCHE missense_variant none ENSG00000090402 'SI 1 known unspecific_effect CD200 chr3 112332347 112362812 1 4345 protein_coding 3:165850059 53517712 129_1_1 SeqId_15620_4 'NLGN1 chr3:173108163_D_I$SeqId_15620_4 1 chr3:173108163_D_I rs10569934 cis 3 173108163 D I 0.3707 0.1491 0.0133 4.23e-29 'Neuroligin-1 ENSG00000169760 'NLGN1 intergenic_variant ENSG00000169760 ENSG00000169760 'NLGN1 3 novel specific_protein NLGN1 chr3 173396284 174286644 1 22871 protein_coding 3:173390374 5910 13_1_1 SeqId_10391_1 'ANGL3 chr1:62915473_C_T$SeqId_10391_1 1 chr1:62915473_C_T rs11207970 cis 1 62915473 T C 0.3459 -0.2817 0.0135 2.13e-96 'Angiopoietin-related protein 3 ENSG00000132855 'ANGPTL3 intron_variant ENSG00000132855 ENSG00000132855 'ANGPTL3 5 known unspecific_effect -0.20279 0.065622 0.00211446256165259 yes ANGPTL3 Olink CARDIOMETABOLIC(v.3602) ANGPTL3 chr1 62597520 62606313 1 27329 protein_coding 1:62449802 147718 13_2_1 SeqId_9173_21 'PGM1 chr1:64107284_C_T$SeqId_9173_21 1 chr1:64107284_C_T rs2269247 cis 1 64107284 T C 0.1748 0.2107 0.0176 4.11e-33 'Phosphoglucomutase-1 ENSG00000079739 'PGM1 intron_variant 0.941914 rs11208257 ENSG00000079739 'PGM1 missense_variant ENSG00000079739 ENSG00000079739 'PGM1 3 novel specific_protein PGM1 chr1 63593411 63660245 1 5236 protein_coding 1:63641613 48202 13_2_2 SeqId_2590_69 'ROR1 chr1:64611828_C_T$SeqId_2590_69 1 chr1:64611828_C_T rs61765448 cis 1 64611828 T C 0.1679 -0.2344 0.0175 4.21e-41 'Inactive tyrosine-protein kinase transmembrane receptor ROR1 ENSG00000185483 'ROR1 intron_variant 0.18366 rs7527017 ENSG00000185483 'ROR1 missense_variant ENSG00000185483 ENSG00000185483 'ROR1 3 known specific_protein -0.25065 0.088591 0.00485959414346272 yes ROR1 Olink METABOLISM(v.3402) ROR1 chr1 63774017 64181498 1 4919 protein_coding 1:64146145 372128 13_3_1 SeqId_4337_49 'CRP chr1:66099831_C_T$SeqId_4337_49 1 chr1:66099831_C_T rs12034502 trans 1 66099831 T C 0.3827 -0.14 0.0137 1.88e-24 'C-reactive protein ENSG00000132693 'CRP intron_variant 0.345286 rs1805094 ENSG00000116678 'LEPR missense_variant ENSG00000116675|ENSG00000118473|ENSG00000162434 ENSG00000116675|ENSG00000118473|ENSG00000162434|ENSG00000184588 'DNAJC6|JAK1|PDE4B|SGIP1 1 known specific_pathway CRP chr1 159712289 159714589 -1 1401 protein_coding 1:65634148 94080441 13_3_2 SeqId_5400_52 'sLeptin R chr1:66073982_C_T$SeqId_5400_52 1 chr1:66073982_C_T rs10399687 cis 1 66073982 T C 0.1763 -1.3837 0.0115 1.29e-3146 'Leptin receptor ENSG00000116678 'LEPR intron_variant 0.997295 rs1805094 ENSG00000116678 'LEPR missense_variant ENSG00000116678 ENSG00000116678 'LEPR 3 known suggestive_specific_pathway -0.51365 0.079831 2.98813352456845e-10 yes LEPR Olink NEURO EXPLORATORY(v.3901) LEPR chr1 65420652 65641559 1 3953 protein_coding 1:65608299 187647 13_4_1 SeqId_10462_14 'INSL5 chr1:67269905_A_G$SeqId_10462_14 1 chr1:67269905_A_G rs11809759 cis 1 67269905 A G 0.6081 -0.1065 0.014 2.92e-14 'Insulin-like peptide INSL5 ENSG00000172410 'INSL5 upstream_gene_variant 0.108437 rs549148 ENSG00000172410 'INSL5 missense_variant ENSG00000172410 ENSG00000172410 'INSL5 3 known specific_protein INSL5 chr1 66797740 66801276 -1 10022 protein_coding 1:66804222 2946 130_1_1 SeqId_3390_72 'PIK3CA/PIK3R1 chr3:178767098_C_T$SeqId_3390_72 1 chr3:178767098_C_T rs4637331 cis 3 178767098 T C 0.2475 -0.2499 0.015 3.39e-62 'PIK3CA/PIK3R1 ENSG00000145675|ENSG00000121879 'PIK3R1|PIK3CA intron_variant ENSG00000145675|ENSG00000121879 ENSG00000121879|ENSG00000145675 'PIK3CA|PIK3R1 3 novel specific_protein PIK3CA chr3 179148114 179240093 1 5290 protein_coding 3:179049310 98804 131_1_10 SeqId_3581_53 'a2-HS-Glycoprotein chr3:186328342_G_T$SeqId_3581_53 1 chr3:186328342_G_T rs10937258 cis 3 186328342 T G 0.7199 0.5588 0.014 2.25e-348 'Alpha-2-HS-glycoprotein ENSG00000145192 'AHSG upstream_gene_variant 0.560428 rs4918 ENSG00000145192 'AHSG missense_variant ENSG00000145192 ENSG00000145192 'AHSG 3 known unspecific_effect AHSG chr3 186613060 186621318 1 197 protein_coding 3:186610553 2507 131_1_14 SeqId_3367_8 'FETUB chr3:186448928_C_T$SeqId_3367_8 1 chr3:186448928_C_T rs5030103 cis 3 186448928 T C 0.9874 1.5092 0.0582 2.94e-148 'Fetuin-B ENSG00000090512 'FETUB intron_variant ENSG00000090512 ENSG00000090512 'FETUB 3 novel unspecific_effect 1.4044 0.24258 1.27086669939282e-08 yes FETUB Olink CARDIOMETABOLIC(v.3602) FETUB chr3 186635969 186653141 1 26998 protein_coding 3:186731139 95170 131_1_15 SeqId_7784_1 'Kininogen, HMW chr3:186461524_C_T$SeqId_7784_1 1 chr3:186461524_C_T rs76438938 cis 3 186461524 T C 0.0302 -1.1904 0.0384 2.02e-211 'Kininogen-1 ENSG00000113889 'KNG1 downstream_gene_variant ENSG00000113889 ENSG00000113889 'KNG1 3 known suggestive_specific_pathway KNG1 chr3 186717348 186744410 1 3827 protein_coding 3:186743735 26387 131_1_16 SeqId_3554_24 'Adiponectin chr3:186561201_A_C$SeqId_3554_24 1 chr3:186561201_A_C rs141134215 cis 3 186561201 A C 0.026 -0.6644 0.0364 2.22e-74 'Adiponectin ENSG00000181092 'ADIPOQ intron_variant ENSG00000181092 ENSG00000181092 'ADIPOQ 3 known specific_protein ADIPOQ chr3 186842704 186858463 1 9370 protein_coding 3:186843412 708 131_1_2 SeqId_5116_62 'ROBO2 chr3:186445052_G_T$SeqId_5116_62 1 chr3:186445052_G_T rs2304456 trans 3 186445052 T G 0.8901 -0.1695 0.0204 9.36e-17 'Roundabout homolog 2 ENSG00000185008 'ROBO2 missense_variant ENSG00000113889 ENSG00000113889 'KNG1 3 known unspecific_effect ROBO2 chr3 75906695 77649964 1 6092 protein_coding 3:186727263 110820568 131_1_3 SeqId_6941_11 'SUMF1 chr3:186341025_C_T$SeqId_6941_11 1 chr3:186341025_C_T rs149062332 trans 3 186341025 T C 0.9882 -0.6046 0.0643 5.01e-21 'Sulfatase-modifying factor 1 ENSG00000144455 'SUMF1 downstream_gene_variant 0.852757 rs35457250 ENSG00000145192 'AHSG missense_variant ENSG00000145192 ENSG00000145192 'AHSG 4 known unspecific_effect SUMF1 chr3 3700814 4467273 -1 285362 protein_coding 3:186623236 182155963 131_1_4 SeqId_15343_337 'Kininogen, HMW, Two Chain chr3:186454180_A_C$SeqId_15343_337 1 chr3:186454180_A_C rs5030062 cis 3 186454180 A C 0.6316 -0.4816 0.0132 8.4e-293 'Kininogen, HMW, Two Chain ENSG00000113889 'KNG1 intron_variant 0.861136 rs710446 ENSG00000113889 'KNG1 missense_variant ENSG00000113889 ENSG00000113889 'KNG1 6 known unspecific_effect KNG1 chr3 186717348 186744410 1 3827 protein_coding 3:186736391 19043 131_1_4 SeqId_19631_13 'Kininostatin chr3:186459927_C_T$SeqId_19631_13 1 chr3:186459927_C_T rs710446 cis 3 186459927 T C 0.5982 -0.2451 0.0129 3.81e-80 'Kininostatin ENSG00000113889 'KNG1 missense_variant ENSG00000113889 ENSG00000113889 'KNG1 6 known unspecific_effect KNG1 chr3 186717348 186744410 1 3827 protein_coding 3:186742138 24790 131_1_6 SeqId_4996_66 'HRG chr3:186391274_A_G$SeqId_4996_66 1 chr3:186391274_A_G rs59123177 cis 3 186391274 A G 0.3496 1.0529 0.0101 1.06e-2362 'Histidine-rich glycoprotein ENSG00000113905 'HRG intron_variant 0.932592 rs9898 ENSG00000113905 'HRG missense_variant ENSG00000113905 ENSG00000113905 'HRG 6 known unspecific_effect HRG chr3 186660216 186678234 1 3273 protein_coding 3:186673485 13269 131_1_6 SeqId_8087_250 'RNF13 chr3:186389769_G_T$SeqId_8087_250 1 chr3:186389769_G_T rs114232169 trans 3 186389769 T G 0.3406 0.1355 0.0145 8.7e-21 'E3 ubiquitin-protein ligase RNF13 ENSG00000082996 'RNF13 intron_variant 0.976654 rs9898 ENSG00000113905 'HRG missense_variant ENSG00000113905 ENSG00000113905 'HRG 6 known unspecific_effect RNF13 chr3 149812770 149962139 1 11342 protein_coding 3:186671980 36859210 131_1_7 SeqId_13501_10 'S35G2 chr3:186395113_A_G$SeqId_13501_10 1 chr3:186395113_A_G rs2228243 trans 3 186395113 A G 0.7992 -0.3032 0.0166 2.42e-74 'Solute carrier family 35 member G2 ENSG00000168917 'SLC35G2 missense_variant ENSG00000113905 ENSG00000113905 'HRG 3 known unspecific_effect SLC35G2 chr3 136818647 136855888 1 80723 protein_coding 3:186677324 49858677 131_1_9 SeqId_7110_2 'DJB11 chr3:186287166_A_G$SeqId_7110_2 1 chr3:186287166_A_G rs56324474 cis 3 186287166 A G 0.0853 -0.2844 0.0226 3.51e-36 'DnaJ homolog subfamily B member 11 ENSG00000090520 'DNAJB11 intron_variant 0.461866 rs8147 ENSG00000090520 'DNAJB11 missense_variant ENSG00000090520 ENSG00000090520 'DNAJB11 3 known specific_protein DNAJB11 chr3 186567403 186585800 1 51726 protein_coding 3:186569377 1974 131_2_3 SeqId_3605_77 'MASP3 chr3:186982263_D_I$SeqId_3605_77 1 chr3:186982263_D_I rs34053057 cis 3 186982263 D I 0.6673 0.1372 0.0146 6.77e-21 'Mannan-binding lectin serine protease 1 ENSG00000127241 'MASP1 intron_variant ENSG00000127241 ENSG00000127241 'MASP1 3 novel unspecific_effect 0.25942 0.068111 0.000157579602274392 yes MASP1 Olink IMMUNE RESPONSE(v.3202) MASP1 chr3 187217282 187291980 -1 5648 protein_coding 3:187264476 27504 131_2_5 SeqId_18315_38 'RTP4 chr3:187093692_A_G$SeqId_18315_38 1 chr3:187093692_A_G rs1878861 cis 3 187093692 A G 0.602 -0.4567 0.0124 2.96e-295 'Receptor-transporting protein 4 ENSG00000136514 'RTP4 downstream_gene_variant 0.359338 rs3821812 ENSG00000136514 'RTP4 missense_variant ENSG00000136514 ENSG00000136514 'RTP4 3 novel specific_protein RTP4 chr3 187368385 187372076 1 64108 protein_coding 3:187375904 7519 132_1_1 SeqId_14048_7 'IL-1 R AcP chr3:190348515_A_G$SeqId_14048_7 1 chr3:190348515_A_G rs7642797 cis 3 190348515 A G 0.8472 -1.3925 0.0126 4.73e-2655 'Interleukin-1 Receptor accessory protein ENSG00000196083 'IL1RAP intron_variant ENSG00000196083 ENSG00000196083 'IL1RAP 3 known specific_protein IL1RAP chr3 190514051 190659750 1 3556 protein_coding 3:190630726 116675 133_1_2 SeqId_6415_90 'CPN2 chr3:194062519_C_T$SeqId_6415_90 1 chr3:194062519_C_T rs3732477 cis 3 194062519 T C 0.2826 -0.6457 0.0137 7.32e-485 'Carboxypeptidase N subunit 2 ENSG00000178772 'CPN2 missense_variant ENSG00000178772 ENSG00000178772 'CPN2 7 known unspecific_effect CPN2 chr3 194339768 194351328 -1 1370 protein_coding 3:194341790 9538 133_1_3 SeqId_10835_25 'A4GCT chr3:194064298_A_C$SeqId_10835_25 1 chr3:194064298_A_C rs7630163 trans 3 194064298 A C 0.3806 0.1492 0.014 2.2e-26 'Alpha-1,4-N-acetylglucosaminyltransferase ENSG00000118017 'A4GNT intron_variant 0.988308 rs4974539 ENSG00000178772 'CPN2 stop_gained ENSG00000178772 ENSG00000178772 'CPN2 3 known suggestive_specific_pathway A4GNT chr3 138123713 138132390 -1 51146 protein_coding 3:194343569 56211179 133_1_4 SeqId_6557_50 'LRC15 chr3:194089001_C_G$SeqId_6557_50 1 chr3:194089001_C_G rs34461611 cis 3 194089001 C G 0.8941 -0.6121 0.0215 1.52e-178 'Leucine-rich repeat-containing protein 15 ENSG00000172061 'LRRC15 upstream_gene_variant ENSG00000172061 ENSG00000172061 'LRRC15 3 known unspecific_effect LRRC15 chr3 194355249 194369743 -1 131578 protein_coding 3:194368272 1471 133_1_5 SeqId_7185_29 'GPV chr3:194120998_A_G$SeqId_7185_29 1 chr3:194120998_A_G rs1466733 cis 3 194120998 A G 0.7588 0.1402 0.0145 3.46e-22 'Platelet glycoprotein V ENSG00000178732 'GP5 upstream_gene_variant ENSG00000178732 ENSG00000178732 'GP5 3 known specific_protein GP5 chr3 194394821 194399266 -1 2814 protein_coding 3:194400269 1003 133_2_1 SeqId_6375_75 'XXLT1 chr3:195007852_C_T$SeqId_6375_75 1 chr3:195007852_C_T rs1538767 cis 3 195007852 T C 0.4116 -0.1785 0.0133 4.55e-41 'Xyloside xylosyltransferase 1 ENSG00000173950 'XXYLT1 intron_variant ENSG00000173950 ENSG00000173950 'XXYLT1 3 known specific_protein XXYLT1 chr3 195068284 195271159 -1 152002 protein_coding 3:195287123 15964 133_2_2 SeqId_8795_48 'TR chr3:195838613_C_T$SeqId_8795_48 1 chr3:195838613_C_T rs11917973 cis 3 195838613 T C 0.4554 0.0975 0.0134 4.09e-13 'Transferrin receptor protein 1 ENSG00000072274 'TFRC intergenic_variant 0.367448 rs3817672 ENSG00000072274 'TFRC missense_variant ENSG00000072274 ENSG00000072274 'TFRC 3 known specific_protein TFRC chr3 196027183 196082096 -1 7037 protein_coding 3:196111742 29646 134_1_2 SeqId_3169_70 'IDUA chr4:977270_A_G$SeqId_3169_70 1 chr4:977270_A_G rs4690219 cis 4 977270 A G 0.6386 0.5793 0.013 1.14e-433 'Alpha-L-iduronidase ENSG00000127415 'IDUA upstream_gene_variant 0.444031 rs10794537 ENSG00000127415 'IDUA missense_variant ENSG00000127415 ENSG00000127415 'IDUA 3 known unspecific_effect 0.591 0.05873 9.57194071294848e-22 yes IDUA Olink CARDIOVASCULAR II(v.5004) IDUA chr4 986997 1004564 1 3425 protein_coding 4:983482 3515 134_1_4 SeqId_8099_42 'SPON2 chr4:1122634_A_G$SeqId_8099_42 1 chr4:1122634_A_G rs6826705 cis 4 1122634 A G 0.3052 0.3062 0.0134 8.92e-115 'Spondin-2 ENSG00000159674 'SPON2 intron_variant 0.932897 rs2279279 ENSG00000159674 'SPON2 missense_variant ENSG00000159674 ENSG00000159674 'SPON2 3 known suggestive_specific_pathway 0.21417 0.067441 0.00159074292375022 yes SPON2 Olink CARDIOVASCULAR II(v.5004) SPON2 chr4 1166932 1208962 -1 10417 protein_coding 4:1128846 80116 134_2_1 SeqId_13669_6 'FGFR-3 chr4:1762974_A_G$SeqId_13669_6 1 chr4:1762974_A_G rs4533828 cis 4 1762974 A G 0.5879 -0.1121 0.0134 7.25e-17 'Fibroblast growth factor receptor 3 ENSG00000068078 'FGFR3 intergenic_variant ENSG00000068078 ENSG00000068078 'FGFR3 3 known specific_protein FGFR3 chr4 1793293 1808872 1 2261 protein_coding 4:1761247 32046 134_2_2 SeqId_7769_29 '3BP2 chr4:2771461_C_T$SeqId_7769_29 1 chr4:2771461_C_T rs2880007 cis 4 2771461 T C 0.5389 -0.4626 0.0123 5.37e-308 'SH3 domain-binding protein 2 ENSG00000087266 'SH3BP2 regulatory_region_variant ENSG00000087266 ENSG00000087266 'SH3BP2 3 novel specific_protein SH3BP2 chr4 2793071 2841098 1 6452 protein_coding 4:2769734 23337 134_3_2 SeqId_3617_80 'HGFA chr4:3451109_A_G$SeqId_3617_80 1 chr4:3451109_A_G rs2498323 cis 4 3451109 A G 0.099 -1.5158 0.0175 6.47e-1632 'Hepatocyte growth factor activator ENSG00000109758 'HGFAC missense_variant ENSG00000109758 ENSG00000109758 'HGFAC 3 known suggestive_specific_pathway HGFAC chr4 3441968 3449486 1 3083 protein_coding 4:3449382 7414 134_3_3 SeqId_3640_14 'RAP chr4:3516559_C_T$SeqId_3640_14 1 chr4:3516559_C_T rs1800493 cis 4 3516559 T C 0.0166 -1.0953 0.0521 2.83e-98 'alpha-2-macroglobulin receptor-associated protein ENSG00000163956 'LRPAP1 missense_variant ENSG00000163956 ENSG00000163956 'LRPAP1 3 known specific_protein -0.19018 0.22985 0.408422820345785 no Alpha-2-MRAP Olink NEUROLOGY(v.8011) LRPAP1 chr4 3503612 3532446 -1 4043 protein_coding 4:3514832 17614 135_1_1 SeqId_8402_22 'CYTL1 chr4:5020092_A_G$SeqId_8402_22 1 chr4:5020092_A_G rs62291577 cis 4 5020092 A G 0.8408 -0.2741 0.0183 1.44e-50 'Cytokine-like protein 1 ENSG00000170891 'CYTL1 intron_variant ENSG00000170891 ENSG00000170891 'CYTL1 3 known specific_protein CYTL1 chr4 5014586 5019458 -1 54360 protein_coding 4:5018365 1093 136_1_1 SeqId_9251_28 'MA2B2 chr4:6599684_A_T$SeqId_9251_28 1 chr4:6599684_A_T rs2301791 cis 4 6599684 A T 0.4726 0.8257 0.0107 8.26e-1296 'Epididymis-specific alpha-mannosidase ENSG00000013288 'MAN2B2 intron_variant 0.99054 rs2301790 ENSG00000013288 'MAN2B2 missense_variant ENSG00000013288 ENSG00000013288 'MAN2B2 3 known specific_protein MAN2B2 chr4 6575189 6623362 1 23324 protein_coding 4:6597957 22768 136_2_1 SeqId_7113_1 'GRPE1 chr4:7069377_C_G$SeqId_7113_1 1 chr4:7069377_C_G rs56659624 cis 4 7069377 C G 0.0908 -0.2663 0.0219 4.39e-34 'GrpE protein homolog 1, mitochondrial ENSG00000109519 'GRPEL1 intron_variant ENSG00000109519 ENSG00000109519 'GRPEL1 3 novel specific_protein GRPEL1 chr4 7058895 7068064 -1 80273 protein_coding 4:7067650 414 136_2_3 SeqId_8814_33 'SAPL1 chr4:7436997_C_T$SeqId_8814_33 1 chr4:7436997_C_T rs4484302 cis 4 7436997 T C 0.8341 -0.55 0.0171 7.18e-228 'Proactivator polypeptide-like 1 ENSG00000178597 'PSAPL1 intron_variant 0.157264 rs56269914 ENSG00000178597 'PSAPL1 missense_variant ENSG00000178597 ENSG00000178597 'PSAPL1 3 known specific_protein PSAPL1 chr4 7430285 7434930 -1 768239 protein_coding 4:7435270 340 136_3_1 SeqId_19196_73 'HOP chr4:7784085_C_T$SeqId_19196_73 1 chr4:7784085_C_T rs35617438 trans 4 7784085 T C 0.2955 0.3466 0.0144 3.33e-128 'Homeodomain-only protein ENSG00000171476 'HOPX intron_variant 0.994115 rs41264705 ENSG00000196526 'AFAP1 missense_variant ENSG00000196526 ENSG00000196526 'AFAP1 3 novel specific_protein HOPX chr4 56647988 56681899 -1 84525 protein_coding 4:7782358 48899541 136_4_1 SeqId_6493_9 'CBPZ chr4:8597746_D_I$SeqId_6493_9 1 chr4:8597746_D_I rs112647539 cis 4 8597746 D I 0.3286 0.1327 0.0149 6.48e-19 'Carboxypeptidase Z ENSG00000109625 'CPZ intron_variant 0.852609 rs2302583 ENSG00000109625 'CPZ missense_variant ENSG00000109625 ENSG00000109625 'CPZ 3 novel specific_protein CPZ chr4 8592660 8619759 1 8532 protein_coding 4:8596020 3360 137_1_1 SeqId_4535_50 'BST1 chr4:15714762_A_G$SeqId_4535_50 1 chr4:15714762_A_G rs73224660 cis 4 15714762 A G 0.1602 -1.2932 0.0128 2.56e-2219 'ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 ENSG00000109743 'BST1 intron_variant 0.635204 rs4320134 ENSG00000109743 'BST1 stop_lost ENSG00000109743 ENSG00000109743 'BST1 3 known specific_protein -1.0939 0.068574 2.44343055269396e-46 yes BST1 Olink DEVELOPMENT(v.3511) BST1 chr4 15703065 15738313 1 683 protein_coding 4:15713139 10074 137_2_1 SeqId_15579_26 'ENPP6 chr4:16134373_A_G$SeqId_15579_26 1 chr4:16134373_A_G rs56922149 trans 4 16134373 A G 0.7334 -0.1167 0.0153 2.63e-14 'Ectonucleotide pyrophosphatase/phosphodiesterase family member 6 ENSG00000164303 'ENPP6 intergenic_variant none none ' novel specific_protein ENPP6 chr4 184088706 184221230 -1 133121 protein_coding 4:16132750 168088480 138_1_1 SeqId_11257_1 'DHPR chr4:17517242_C_T$SeqId_11257_1 1 chr4:17517242_C_T rs28382333 cis 4 17517242 T C 0.2372 -0.5057 0.0137 3.73e-297 'Dihydropteridine reductase ENSG00000151552 'QDPR intron_variant ENSG00000151552 ENSG00000151552 'QDPR 3 known specific_protein -0.36298 0.073793 1.19536352567372e-06 yes QDPR Olink METABOLISM(v.3402) QDPR chr4 17460261 17512206 -1 5860 protein_coding 4:17515619 3413 138_1_2 SeqId_15610_72 'LAP chr4:17589824_D_I$SeqId_15610_72 1 chr4:17589824_D_I rs11333479 cis 4 17589824 D I 0.6298 0.1037 0.0133 6.85e-15 'Cytosol aminopeptidase ENSG00000002549 'LAP3 intron_variant ENSG00000002549 ENSG00000002549 'LAP3 3 novel unspecific_effect LAP3 chr4 17577198 17607972 1 51056 protein_coding 4:17588202 11004 139_1_1 SeqId_18930_28 'SLIT2 chr4:19578455_A_C$SeqId_18930_28 1 chr4:19578455_A_C rs62298859 trans 4 19578455 A C 0.2562 0.099 0.0145 9.11e-12 'Slit homolog 2 protein ENSG00000145147 'SLIT2 intron_variant ENSG00000145147 ENSG00000145147 'SLIT2 3 novel specific_protein SLIT2 chr4 20251905 20620561 1 9353 protein_coding 4:19576832 675073 14_1_1 SeqId_13109_82 'NEGR1 chr1:72714220_C_T$SeqId_13109_82 1 chr1:72714220_C_T rs1194278 cis 1 72714220 T C 0.5039 0.1875 0.0132 1.54e-45 'Neuronal growth regulator 1 ENSG00000172260 'NEGR1 intron_variant ENSG00000172260 ENSG00000172260 'NEGR1 3 known unspecific_effect NEGR1 chr1 71395943 72282539 -1 257194 protein_coding 1:72248537 34002 14_1_1 SeqId_7050_5 'NEGR1 chr1:72713559_C_T$SeqId_7050_5 1 chr1:72713559_C_T rs1194282 cis 1 72713559 T C 0.4958 -0.1589 0.0134 2.9e-32 'Neuronal growth regulator 1 ENSG00000172260 'NEGR1 intron_variant ENSG00000172260 ENSG00000172260 'NEGR1 3 known unspecific_effect NEGR1 chr1 71395943 72282539 -1 257194 protein_coding 1:72247876 34663 140_1_1 SeqId_5660_51 'SOD3 chr4:24801834_C_G$SeqId_5660_51 1 chr4:24801834_C_G rs1799895 cis 4 24801834 C G 0.9851 -2.1887 0.0503 1.32e-413 'Extracellular superoxide dismutase [Cu-Zn] ENSG00000109610 'SOD3 missense_variant ENSG00000109610 ENSG00000109610 'SOD3 6 known unspecific_effect SOD3 chr4 24789912 24800842 1 6649 protein_coding 4:24800212 10300 140_1_2 SeqId_17357_33 'SPCS chr4:25115598_C_G$SeqId_17357_33 1 chr4:25115598_C_G rs4697549 cis 4 25115598 C G 0.0452 -0.3888 0.0307 1.0e-36 'O-phosphoseryl-tRNA(Sec) selenium transferase ENSG00000109618 'SEPSECS regulatory_region_variant 0.978562 rs2302566 ENSG00000109618 'SEPSECS missense_variant ENSG00000109618 ENSG00000109618 'SEPSECS 3 novel specific_protein SEPSECS chr4 25120014 25160550 -1 51091 protein_coding 4:25113976 46574 141_1_1 SeqId_18330_7 'PGM2 chr4:37834324_C_T$SeqId_18330_7 1 chr4:37834324_C_T rs2911906 cis 4 37834324 T C 0.1922 -0.1662 0.0164 4.41e-24 'Phosphoglucomutase-2 ENSG00000169299 'PGM2 intron_variant ENSG00000169299 ENSG00000169299 'PGM2 3 novel specific_protein PGM2 chr4 37826660 37862937 1 55276 protein_coding 4:37832702 6042 141_1_2 SeqId_16324_38 'TLR1 chr4:38798648_A_C$SeqId_16324_38 1 chr4:38798648_A_C rs5743618 cis 4 38798648 A C 0.2782 0.1129 0.015 4.66e-14 'Toll-like receptor 1 ENSG00000174125 'TLR1 missense_variant ENSG00000174125 ENSG00000174125 'TLR1 3 known specific_protein TLR1 chr4 38790677 38856817 -1 7096 protein_coding 4:38797027 59790 141_2_1 SeqId_19557_3 'KLOTB chr4:39427201_C_T$SeqId_19557_3 1 chr4:39427201_C_T rs2608817 cis 4 39427201 T C 0.6149 -0.6123 0.0123 1.24e-540 'Beta-klotho ENSG00000134962 'KLB intron_variant 0.130658 rs4975017 ENSG00000134962 'KLB missense_variant ENSG00000134962 ENSG00000134962 'KLB 3 novel specific_protein -0.37376 0.061264 2.1632165654073e-09 yes KLB Olink NEURO EXPLORATORY(v.3901) KLB chr4 39406930 39451533 1 152831 protein_coding 4:39425581 18651 141_2_3 SeqId_17755_5 'UGDH chr4:39522223_C_T$SeqId_17755_5 1 chr4:39522223_C_T rs7669821 cis 4 39522223 T C 0.5823 0.4689 0.0126 3.32e-305 'UDP-glucose 6-dehydrogenase ENSG00000109814 'UGDH intron_variant ENSG00000109814 ENSG00000109814 'UGDH 3 novel specific_pathway UGDH chr4 39498755 39528311 -1 7358 protein_coding 4:39520603 7708 142_1_1 SeqId_16079_2 'TEC chr4:48181697_A_G$SeqId_16079_2 1 chr4:48181697_A_G rs6845258 cis 4 48181697 A G 0.4144 0.1517 0.0129 4.22e-32 'Tyrosine-protein kinase Tec ENSG00000135605 'TEC intron_variant ENSG00000135605 ENSG00000135605 'TEC 3 novel specific_protein TEC chr4 48135783 48269838 -1 7006 protein_coding 4:48179680 90158 143_1_1 SeqId_10366_11 'PDGFRA chr4:55141293_A_G$SeqId_10366_11 1 chr4:55141293_A_G rs2307050 cis 4 55141293 A G 0.1103 -0.1975 0.021 6.33e-21 'Platelet-derived growth factor receptor alpha ENSG00000134853 'PDGFRA intron_variant 0.997732 rs35597368 ENSG00000134853 'PDGFRA missense_variant ENSG00000134853 ENSG00000134853 'PDGFRA 3 known specific_protein PDGFRA chr4 54229280 54298245 1 5156 protein_coding 4:54275126 45846 143_2_1 SeqId_3651_50 'VEGF sR2 chr4:55972946_A_G$SeqId_3651_50 1 chr4:55972946_A_G rs34231037 cis 4 55972946 A G 0.9683 1.1219 0.0385 2.04e-186 'Vascular endothelial growth factor receptor 2 ENSG00000128052 'KDR missense_variant ENSG00000128052 ENSG00000128052 'KDR 3 known specific_protein 1.3905 0.17583 1.79887091512879e-14 yes VEGFR-2 Olink ONCOLOGY II(v.7002) KDR chr4 55078481 55125595 -1 3791 protein_coding 4:55106779 18816 144_1_2 SeqId_3320_49 'IGFBP-7 chr4:57952002_A_T$SeqId_3320_49 1 chr4:57952002_A_T rs6827768 cis 4 57952002 A T 0.7987 -0.43 0.0162 4.35e-155 'Insulin-like growth factor-binding protein 7 ENSG00000163453 'IGFBP7 intron_variant ENSG00000163453 ENSG00000163453 'IGFBP7 4 known suggestive_specific_pathway -0.35653 0.068671 3.07397265608252e-07 yes IGFBP-7 Olink CARDIOVASCULAR III(v.6112) IGFBP7 chr4 57030773 57110385 -1 3490 protein_coding 4:57085836 24549 144_1_3 SeqId_13405_61 'ISK2 chr4:57688372_A_C$SeqId_13405_61 1 chr4:57688372_A_C rs28488855 cis 4 57688372 A C 0.0208 0.7186 0.0455 4.55e-56 'Serine protease inhibitor Kazal-type 2 ENSG00000128040 'SPINK2 upstream_gene_variant ENSG00000128040 ENSG00000128040 'SPINK2 3 known specific_protein SPINK2 chr4 56809860 56821742 -1 6691 protein_coding 4:56822206 464 145_1_1 SeqId_3806_55 'EphA5 chr4:66433737_C_T$SeqId_3806_55 1 chr4:66433737_C_T rs4860687 cis 4 66433737 T C 0.6302 -0.1206 0.0138 2.69e-18 'Ephrin type-A receptor 5 ENSG00000145242 'EPHA5 intron_variant ENSG00000145242 ENSG00000145242 'EPHA5 3 novel specific_protein EPHA5 chr4 65319563 65670495 -1 2044 protein_coding 4:65568019 102476 146_1_1 SeqId_10603_1 'HIS3 chr4:70933457_A_G$SeqId_10603_1 1 chr4:70933457_A_G rs116569188 cis 4 70933457 A G 0.0192 -0.3499 0.0502 3.27e-12 'Histatin-3 ENSG00000205649 'HTN3 intron_variant 0.392893 rs114647960 ENSG00000205649 'HTN3 missense_variant ENSG00000205649 ENSG00000205649 'HTN3 3 novel specific_protein HTN3 chr4 70028455 70036538 1 3347 protein_coding 4:70067740 39285 147_1_1 SeqId_15589_1 'Gc-Globulin, Mixed Type chr4:72625097_A_C$SeqId_15589_1 1 chr4:72625097_A_C rs7697091 cis 4 72625097 A C 0.6368 0.1589 0.0135 5.46e-32 'Vitamin D-binding protein ENSG00000145321 'GC intron_variant 0.710539 rs4588 ENSG00000145321 'GC missense_variant ENSG00000145321 ENSG00000145321 'GC 3 known specific_protein GC chr4 71741696 71804041 -1 2638 protein_coding 4:71759380 44661 148_1_1 SeqId_12510_3 'STAP1 chr4:74276957_D_I$SeqId_12510_3 1 chr4:74276957_D_I rs536611068 trans 4 74276957 D I 0.6058 -0.0928 0.0133 2.86e-12 'Signal-transducing adaptor protein 1 ENSG00000035720 'STAP1 intron_variant 0.318515 rs12507775 ENSG00000169435 'RASSF6 missense_variant ENSG00000163631 ENSG00000163631 'ALB 2 known specific_protein STAP1 chr4 67558727 67607337 1 26228 protein_coding 4:73411240 5852513 148_1_2 SeqId_10435_2 'ASPG chr4:74280265_C_T$SeqId_10435_2 1 chr4:74280265_C_T rs667 trans 4 74280265 T C 0.2305 -0.1933 0.0154 3.38e-36 'N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase ENSG00000038002 'AGA intron_variant 0.434073 rs12507775 ENSG00000169435 'RASSF6 missense_variant ENSG00000163631 ENSG00000081051|ENSG00000163631 'AFP|ALB 2 known specific_pathway AGA chr4 177430774 177442437 -1 175 protein_coding 4:73414548 104027889 148_1_3 SeqId_4763_31 'Afamin chr4:74359582_C_T$SeqId_4763_31 1 chr4:74359582_C_T rs72856641 cis 4 74359582 T C 0.9797 1.1075 0.0465 2.75e-125 'Afamin ENSG00000079557 'AFM intron_variant 0.977933 rs41265665 ENSG00000079557 'AFM missense_variant ENSG00000079557 ENSG00000079557 'AFM 3 known specific_protein AFM chr4 73481745 73504001 1 173 protein_coding 4:73493865 12120 148_2_1 SeqId_2697_7 'PF-4 chr4:74846661_A_C$SeqId_2697_7 1 chr4:74846661_A_C rs11574452 cis 4 74846661 A C 0.0447 -0.2552 0.0296 6.97e-18 'Platelet factor 4 ENSG00000163737 'PF4 downstream_gene_variant ENSG00000163737 ENSG00000163737 'PF4 7 known unspecific_effect PF4 chr4 73980811 73982027 -1 5196 protein_coding 4:73980944 1083 148_2_1 SeqId_6530_63 'PROL1 chr4:74848065_C_G$SeqId_6530_63 1 chr4:74848065_C_G rs3756074 trans 4 74848065 C G 0.0488 -0.2336 0.0317 1.62e-13 'Opiorphin prepropeptide ENSG00000171199 'PROL1 upstream_gene_variant ENSG00000163737 ENSG00000163737 'PF4 7 known unspecific_effect OPRPN chr4 70397931 70410195 1 58503 protein_coding 4:73982348 3584417 148_2_10 SeqId_3038_9 'I-TAC chr4:76964956_A_G$SeqId_3038_9 1 chr4:76964956_A_G rs35170645 cis 4 76964956 A G 0.4815 0.5104 0.0121 8.04e-389 'C-X-C motif chemokine 11 ENSG00000169248 'CXCL11 intron_variant ENSG00000169248 ENSG00000169248 'CXCL11 3 known unspecific_effect 0.50362 0.056475 9.97700063822551e-18 yes CXCL11 Olink INFLAMMATION(v.3012) CXCL11 chr4 76033682 76041415 -1 6373 protein_coding 4:76043803 2388 148_2_11 SeqId_7970_315 'NAR3 chr4:77030398_D_I$SeqId_7970_315 1 chr4:77030398_D_I rs56062839 cis 4 77030398 D I 0.4292 0.2613 0.0125 2.06e-96 'Ecto-ADP-ribosyltransferase 3 ENSG00000156219 'ART3 intron_variant 0.141341 rs1128864 ENSG00000156219 'ART3 missense_variant ENSG00000156219 ENSG00000156219 'ART3 3 known unspecific_effect ART3 chr4 76011184 76112802 1 419 protein_coding 4:76109246 98062 148_2_2 SeqId_5663_18 'PF4V chr4:74714098_A_G$SeqId_5663_18 1 chr4:74714098_A_G rs2367288 cis 4 74714098 A G 0.7035 -0.8677 0.0122 4.13e-1101 'Platelet factor 4 variant ENSG00000109272 'PF4V1 upstream_gene_variant ENSG00000109272 ENSG00000109272 'PF4V1 5 known unspecific_effect PF4V1 chr4 73853296 73854483 1 5197 protein_coding 4:73848381 4915 148_2_3 SeqId_9188_119 'MIG chr4:76883698_G_T$SeqId_9188_119 1 chr4:76883698_G_T rs55876513 cis 4 76883698 T G 0.7513 0.1234 0.0154 9.5e-16 'C-X-C motif chemokine 9 ENSG00000138755 'CXCL9 intron_variant ENSG00000138755 ENSG00000138744|ENSG00000138755 'CXCL9|NAAA 3 known unspecific_effect 0.2063 0.073111 0.00497507921351441 yes CXCL9 Olink INFLAMMATION(v.3012) CXCL9 chr4 76001275 76007509 -1 4283 protein_coding 4:75962545 44964 148_2_3 SeqId_3173_49 'ASAHL chr4:76855106_A_C$SeqId_3173_49 1 chr4:76855106_A_C rs111981122 cis 4 76855106 A C 0.7666 0.7366 0.0144 1.01e-570 'N-acylethanolamine-hydrolyzing acid amidase ENSG00000138744 'NAAA intron_variant 0.99905 rs4859571 ENSG00000138744 'NAAA missense_variant ENSG00000138744 ENSG00000138744|ENSG00000138755 'CXCL9|NAAA 3 known unspecific_effect 0.59618 0.071534 8.27942163712333e-16 yes NAAA Olink NEUROLOGY(v.8011) NAAA chr4 75913660 75941013 -1 27163 protein_coding 4:75933953 7060 148_2_4 SeqId_3495_15 'GCP-2 chr4:74703999_C_T$SeqId_3495_15 1 chr4:74703999_C_T rs16850073 cis 4 74703999 T C 0.3761 0.8474 0.0113 7.28e-1224 'C-X-C motif chemokine 6 ENSG00000124875 'CXCL6 3_prime_UTR_variant ENSG00000124875 ENSG00000124875 'CXCL6 3 known unspecific_effect 0.7479 0.054646 3.03389118419427e-36 yes CXCL6 Olink INFLAMMATION(v.3012) CXCL6 chr4 73836640 73849064 1 6372 protein_coding 4:73838282 1642 148_2_5 SeqId_2985_35 'Gro-a chr4:74738454_C_G$SeqId_2985_35 1 chr4:74738454_C_G rs3097411 cis 4 74738454 C G 0.7574 -1.0136 0.0121 1.65e-1526 'Growth-regulated alpha protein ENSG00000163739 'CXCL1 downstream_gene_variant ENSG00000163739 ENSG00000163739 'CXCL1 3 known suggestive_specific_pathway -0.60725 0.067397 4.86407205691463e-18 yes CXCL1 Olink CARDIOVASCULAR II(v.5004) CXCL1 chr4 73869393 73871308 1 2919 protein_coding 4:73872737 3344 148_2_6 SeqId_2979_8 'ENA-78 chr4:74864687_G_T$SeqId_2979_8 1 chr4:74864687_G_T rs352045 cis 4 74864687 T G 0.1181 0.6692 0.0191 3.08e-268 'C-X-C motif chemokine 5 ENSG00000163735 'CXCL5 upstream_gene_variant ENSG00000163735 ENSG00000163735 'CXCL5 3 known specific_pathway 0.65987 0.091275 1.91866874067029e-12 yes CXCL5 Olink INFLAMMATION(v.3012) CXCL5 chr4 73995642 73998677 -1 6374 protein_coding 4:73998970 293 148_2_8 SeqId_4956_2 'EPI chr4:75248505_G_T$SeqId_4956_2 1 chr4:75248505_G_T rs78803121 cis 4 75248505 T G 0.0585 -0.2031 0.0286 1.27e-12 'Epiregulin ENSG00000124882 'EREG missense_variant ENSG00000124882 ENSG00000124882 'EREG 3 novel specific_protein -0.0050568 0.13072 0.969158926028582 no EREG Olink NEURO EXPLORATORY(v.3901) EREG chr4 74365145 74388749 1 2069 protein_coding 4:74382788 17643 148_2_9 SeqId_13088_397 'BTC chr4:75719768_C_G$SeqId_13088_397 1 chr4:75719768_C_G rs28690341 cis 4 75719768 C G 0.8665 0.5629 0.0187 1.97e-198 'Betacellulin ENSG00000174808 'BTC 5_prime_UTR_variant 1.0 rs28549760 ENSG00000174808 'BTC missense_variant ENSG00000174808 ENSG00000174808 'BTC 3 novel specific_protein 0.76313 0.084439 3.91741877107783e-18 yes BTC Olink ORGAN DAMAGE(v.3301) BTC chr4 74744759 74794523 -1 685 protein_coding 4:74794558 35 148_3_1 SeqId_12620_3 'Septin-11 chr4:77885451_D_I$SeqId_12620_3 1 chr4:77885451_D_I rs201159384 cis 4 77885451 D I 0.6561 0.1142 0.014 3.86e-16 'Septin-11 ENSG00000138758 'SEPT11 intron_variant ENSG00000138758 ENSG00000138758 'SEPTIN11 3 novel specific_pathway SEPTIN11 chr4 76949751 77040384 1 55752 protein_coding 4:76964299 14548 149_1_2 SeqId_15559_5 'ANTR2 chr4:80741698_C_G$SeqId_15559_5 1 chr4:80741698_C_G rs9996178 cis 4 80741698 C G 0.2088 0.242 0.0162 3.6e-50 'Anthrax toxin receptor 2 ENSG00000163297 'ANTXR2 regulatory_region_variant 0.303752 rs12647691 ENSG00000163297 'ANTXR2 missense_variant ENSG00000163297 ENSG00000163297 'ANTXR2 3 novel suggestive_specific_pathway ANTXR2 chr4 79901146 80125454 -1 118429 protein_coding 4:79820544 304910 15_1_1 SeqId_13983_27 'QOR chr1:75199973_C_T$SeqId_13983_27 1 chr1:75199973_C_T rs28602706 cis 1 75199973 T C 0.4616 0.954 0.0096 3.10e-2147 'Quinone oxidoreductase ENSG00000116791 'CRYZ intron_variant 0.18046 rs3819946 ENSG00000116791 'CRYZ missense_variant ENSG00000116791 ENSG00000116791 'CRYZ 3 known specific_protein CRYZ chr1 74705482 74733408 -1 1429 protein_coding 1:74734289 881 15_1_2 SeqId_17333_20 'ACADM chr1:76195431_D_I$SeqId_17333_20 1 chr1:76195431_D_I rs145024038 cis 1 76195431 D I 0.6978 -0.5123 0.0128 2.86e-350 'Medium-chain specific acyl-CoA dehydrogenase, mitochondrial ENSG00000117054 'ACADM intron_variant ENSG00000117054 ENSG00000117054 'ACADM 3 novel unspecific_effect ACADM chr1 75724431 75787575 1 34 protein_coding 1:75729747 5316 15_2_1 SeqId_18884_22 'DNJB4 chr1:78504264_A_G$SeqId_18884_22 1 chr1:78504264_A_G rs6699769 cis 1 78504264 A G 0.7859 0.2419 0.0158 6.35e-53 'DnaJ homolog subfamily B member 4 ENSG00000162616 'DNAJB4 downstream_gene_variant ENSG00000162616 ENSG00000162616 'DNAJB4 3 novel specific_protein DNAJB4 chr1 77979175 78017964 1 11080 protein_coding 1:78038580 59405 150_1_2 SeqId_5604_30 'HPSE chr4:84223426_C_T$SeqId_5604_30 1 chr4:84223426_C_T rs61751211 cis 4 84223426 T C 0.9885 0.8437 0.0661 2.62e-37 'Heparanase ENSG00000173083 'HPSE splice_region_variant ENSG00000173083 ENSG00000173083 'HPSE 6 novel suggestive_specific_pathway HPSE chr4 83292461 83335153 -1 10855 protein_coding 4:83302273 32880 151_2_1 SeqId_9482_110 'NUDT9 chr4:88359736_D_I$SeqId_9482_110 1 chr4:88359736_D_I rs35189488 cis 4 88359736 D I 0.6534 -0.1064 0.0129 1.61e-16 'ADP-ribose pyrophosphatase, mitochondrial ENSG00000170502 'NUDT9 intron_variant ENSG00000170502 ENSG00000170502 'NUDT9 3 known unspecific_effect NUDT9 chr4 87422573 87459455 1 53343 protein_coding 4:87438585 16012 151_2_2 SeqId_4467_49 'SPARCL1 chr4:88449181_C_T$SeqId_4467_49 1 chr4:88449181_C_T rs7671511 cis 4 88449181 T C 0.2078 0.7146 0.0146 1.02e-522 'SPARC-like protein 1 ENSG00000152583 'SPARCL1 intron_variant 0.419465 rs1049544 ENSG00000152583 'SPARCL1 missense_variant ENSG00000152583 ENSG00000152583 'SPARCL1 3 known specific_protein 0.65246 0.070611 7.79830110523258e-19 yes SPARCL1 Olink CARDIOMETABOLIC(v.3602) SPARCL1 chr4 87473335 87531061 -1 8404 protein_coding 4:87528029 3032 151_2_3 SeqId_3415_61 'BSP chr4:88723210_G_T$SeqId_3415_61 1 chr4:88723210_G_T rs2616262 cis 4 88723210 T G 0.501 -0.1251 0.0135 1.45e-20 'Bone sialoprotein 2 ENSG00000029559 'IBSP intron_variant 0.449811 rs1054629 ENSG00000029559 'IBSP missense_variant ENSG00000029559 ENSG00000029559 'IBSP 3 known specific_protein IBSP chr4 87799554 87812435 1 3381 protein_coding 4:87802058 2504 151_2_4 SeqId_13113_7 'Osteopontin chr4:88897106_D_I$SeqId_13113_7 1 chr4:88897106_D_I rs5860110 cis 4 88897106 D I 0.6989 0.1029 0.0149 5.73e-12 'Osteopontin ENSG00000118785 'SPP1 intron_variant ENSG00000118785 ENSG00000118785 'SPP1 3 novel specific_protein SPP1 chr4 87975667 87983532 1 6696 protein_coding 4:87975955 288 151_4_1 SeqId_8458_111 'a-Synuclein chr4:90813521_A_C$SeqId_8458_111 1 chr4:90813521_A_C rs7356205 cis 4 90813521 A C 0.562 -0.1196 0.0131 9.5e-20 'Alpha-synuclein ENSG00000145335 'SNCA intron_variant ENSG00000145335 ENSG00000145335 'SNCA 3 known specific_protein SNCA chr4 89700345 89838315 -1 6622 protein_coding 4:89892370 54055 152_1_1 SeqId_12549_33 'PTGD2 chr4:95259235_A_C$SeqId_12549_33 1 chr4:95259235_A_C rs6532479 cis 4 95259235 A C 0.6144 0.4252 0.0127 2.78e-244 'Hematopoietic prostaglandin D synthase ENSG00000163106 'HPGDS intron_variant ENSG00000163106 ENSG00000163106 'HPGDS 3 known specific_protein 0.57475 0.059879 4.45656248397504e-20 yes HPGDS Olink ORGAN DAMAGE(v.3301) HPGDS chr4 94298535 94342876 -1 27306 protein_coding 4:94338084 4792 152_2_1 SeqId_5139_32 'UNC5H3 chr4:96405913_C_T$SeqId_5139_32 1 chr4:96405913_C_T rs13134684 cis 4 96405913 T C 0.3473 0.2172 0.0139 8.91e-55 'Netrin receptor UNC5C ENSG00000182168 'UNC5C intron_variant ENSG00000182168 ENSG00000182168 'UNC5C 6 known specific_pathway 0.1568 0.061008 0.010466464385522 yes UNC5C Olink NEUROLOGY(v.8011) UNC5C chr4 95162504 95549206 -1 8633 protein_coding 4:95484762 64444 153_1_1 SeqId_14106_46 'GDP/GTP exchange protein chr4:99349327_A_G$SeqId_14106_46 1 chr4:99349327_A_G rs4699632 cis 4 99349327 A G 0.933 0.2066 0.0253 3.53e-16 'Rap1 GTPase-GDP dissociation stimulator 1 ENSG00000138698 'RAP1GDS1 intron_variant ENSG00000138698 ENSG00000138698 'RAP1GDS1 3 novel specific_protein RAP1GDS1 chr4 98261384 98443858 1 5910 protein_coding 4:98428176 166792 153_2_1 SeqId_11369_23 'ADHX chr4:99987492_A_G$SeqId_11369_23 1 chr4:99987492_A_G rs62325239 cis 4 99987492 A G 0.9622 0.5796 0.032 2.88e-73 'Alcohol dehydrogenase class-3 ENSG00000197894 'ADH5 downstream_gene_variant ENSG00000197894 ENSG00000172955|ENSG00000197894 'ADH5|ADH6 3 novel specific_pathway ADH5 chr4 99070978 99088801 -1 128 protein_coding 4:99066341 22460 153_2_1 SeqId_18206_18 'ADH6 chr4:99987492_A_G$SeqId_18206_18 1 chr4:99987492_A_G rs62325239 cis 4 99987492 A G 0.9622 0.4075 0.0314 1.45e-38 'Alcohol dehydrogenase 6 ENSG00000172955 'ADH6 downstream_gene_variant ENSG00000172955 ENSG00000172955|ENSG00000197894 'ADH5|ADH6 3 novel specific_pathway ADH6 chr4 99202638 99219537 -1 130 protein_coding 4:99066341 153196 153_2_2 SeqId_8325_37 'ADH4 chr4:100065509_G_T$SeqId_8325_37 1 chr4:100065509_G_T rs1800759 cis 4 100065509 T G 0.3907 -0.1052 0.0128 2.67e-16 'Alcohol dehydrogenase 4 ENSG00000198099 'ADH4 upstream_gene_variant 0.69578 rs1126671 ENSG00000198099 'ADH4 missense_variant ENSG00000198099 ENSG00000198099 'ADH4 6 known unspecific_effect ADH4 chr4 99123657 99157792 -1 127 protein_coding 4:99144358 13434 153_2_3 SeqId_17396_23 'ADH1A chr4:100201295_A_G$SeqId_17396_23 1 chr4:100201295_A_G rs28364331 cis 4 100201295 A G 0.983 0.7858 0.052 1.54e-51 'Alcohol dehydrogenase 1A ENSG00000187758 'ADH1A splice_region_variant,intron_variant ENSG00000187758 ENSG00000187758 'ADH1A 3 novel specific_protein ADH1A chr4 99276369 99291003 -1 124 protein_coding 4:99280138 10865 153_2_4 SeqId_11377_19 'ADH7 chr4:100377127_D_I$SeqId_11377_19 1 chr4:100377127_D_I rs146315698 cis 4 100377127 D I 0.0983 -0.4686 0.0223 2.42e-98 'Alcohol dehydrogenase class 4 mu/sigma chain ENSG00000196344 'ADH7 intergenic_variant 0.991655 rs1573496 ENSG00000196344 'ADH7 missense_variant ENSG00000196344 ENSG00000196344 'ADH7 3 known specific_protein ADH7 chr4 99412261 99435510 -1 131 protein_coding 4:99455971 20461 153_3_1 SeqId_11615_16 'DAPP1 chr4:100753152_A_C$SeqId_11615_16 1 chr4:100753152_A_C rs2162386 cis 4 100753152 A C 0.5258 0.0954 0.0132 5.71e-13 'Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide ENSG00000070190 'DAPP1 intron_variant ENSG00000070190 ENSG00000070190 'DAPP1 3 novel specific_protein DAPP1 chr4 99816827 99870190 1 27071 protein_coding 4:99831995 15168 153_3_2 SeqId_8053_16 'DJB14 chr4:100771395_C_T$SeqId_8053_16 1 chr4:100771395_C_T rs55797991 cis 4 100771395 T C 0.1493 -0.1278 0.0186 5.94e-12 'DnaJ homolog subfamily B member 14 ENSG00000164031 'DNAJB14 intron_variant ENSG00000164031 ENSG00000164031 'DNAJB14 3 novel suggestive_specific_pathway DNAJB14 chr4 99896248 99946618 -1 79982 protein_coding 4:99850238 96380 154_1_2 SeqId_4903_72 'Calcineurin chr4:102745985_C_T$SeqId_4903_72 1 chr4:102745985_C_T rs1125271 trans 4 102745985 T C 0.303 0.3521 0.0131 2.07e-158 'Calcineurin ENSG00000221823|ENSG00000138814 'PPP3R1|PPP3CA intron_variant 0.995795 rs10516487 ENSG00000153064 'BANK1 missense_variant ENSG00000153064 ENSG00000153064 'BANK1 3 known unspecific_effect PPP3CA chr4 101023409 101348278 -1 5530 protein_coding 4:101824828 476550 154_2_1 SeqId_9869_28 'NF-kappa-B p105 chr4:103399049_A_C$SeqId_9869_28 1 chr4:103399049_A_C rs62328536 cis 4 103399049 A C 0.3439 0.1476 0.0133 1.71e-28 'Nuclear factor NF-kappa-B p105 subunit ENSG00000109320 'NFKB1 intergenic_variant ENSG00000109320 ENSG00000109320 'NFKB1 5 known unspecific_effect NFKB1 chr4 102501331 102617302 1 4790 protein_coding 4:102477892 23439 154_2_2 SeqId_6382_17 'MANBA chr4:103675108_C_G$SeqId_6382_17 1 chr4:103675108_C_G rs223492 cis 4 103675108 C G 0.3533 0.4862 0.0133 1.93e-291 'Beta-mannosidase ENSG00000109323 'MANBA intron_variant 0.371402 rs227368 ENSG00000109323 'MANBA missense_variant ENSG00000109323 ENSG00000109323 'MANBA 3 known unspecific_effect MANBA chr4 102630770 102760994 -1 4126 protein_coding 4:102753951 7043 154_2_3 SeqId_17329_2 'BDH2 chr4:104111414_C_T$SeqId_17329_2 1 chr4:104111414_C_T rs78336913 cis 4 104111414 T C 0.1852 0.3133 0.0162 4.27e-83 '3-hydroxybutyrate dehydrogenase type 2 ENSG00000164039 'BDH2 intron_variant 0.829322 rs1054707 ENSG00000164039 'BDH2 missense_variant ENSG00000164039 ENSG00000164039 'BDH2 3 novel unspecific_effect BDH2 chr4 103077592 103099870 -1 56898 protein_coding 4:103190257 90387 155_1_3 SeqId_6342_10 'Nephronectin chr4:106819053_A_G$SeqId_6342_10 1 chr4:106819053_A_G rs34712979 cis 4 106819053 A G 0.2557 -0.172 0.0158 1.27e-27 'Nephronectin ENSG00000168743 'NPNT splice_region_variant 0.157421 rs35132891 ENSG00000168743 'NPNT missense_variant ENSG00000168743 ENSG00000168743 'NPNT 3 known specific_protein NPNT chr4 105894775 106004027 1 255743 protein_coding 4:105897896 3121 156_1_1 SeqId_17739_1 'HCDH chr4:108925253_C_T$SeqId_17739_1 1 chr4:108925253_C_T rs62311424 cis 4 108925253 T C 0.9395 0.1908 0.0263 4.3e-13 'Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial ENSG00000138796 'HADH intron_variant ENSG00000138796 ENSG00000138796 'HADH 3 novel specific_protein HADH chr4 107989714 108035241 1 3033 protein_coding 4:108004097 14383 157_1_1 SeqId_2567_5 'Factor I chr4:110656730_A_G$SeqId_2567_5 1 chr4:110656730_A_G rs7439493 cis 4 110656730 A G 0.4163 0.2646 0.0136 7.04e-85 'Complement factor I ENSG00000205403 'CFI intergenic_variant ENSG00000205403 ENSG00000205403 'CFI 3 known specific_protein CFI chr4 109740694 109801999 -1 3426 protein_coding 4:109735574 66425 157_1_2 SeqId_5509_7 'EGF chr4:110854544_C_T$SeqId_5509_7 1 chr4:110854544_C_T rs3822288 cis 4 110854544 T C 0.3368 0.0952 0.0126 3.49e-14 'Epidermal growth factor ENSG00000138798 'EGF intron_variant 0.631141 rs2237051 ENSG00000138798 'EGF missense_variant ENSG00000138798 ENSG00000138798 'EGF 3 known specific_protein 0.20417 0.064 0.0015146071407034 yes EGF Olink ONCOLOGY II(v.7002) EGF chr4 109912883 110013766 1 1950 protein_coding 4:109933388 20505 157_2_1 SeqId_15558_63 'AMPE chr4:111431444_A_G$SeqId_15558_63 1 chr4:111431444_A_G rs33966350 cis 4 111431444 A G 0.0112 -1.5944 0.0606 2.36e-152 'Glutamyl aminopeptidase ENSG00000138792 'ENPEP stop_gained ENSG00000138792 ENSG00000138792 'ENPEP 3 novel specific_protein ENPEP chr4 110365733 110565285 1 2028 protein_coding 4:110510288 144555 158_1_1 SeqId_3419_49 'CAMK2D chr4:114668476_A_T$SeqId_3419_49 1 chr4:114668476_A_T rs115143758 cis 4 114668476 A T 0.5264 -0.0937 0.0132 1.51e-12 'Calcium/calmodulin-dependent protein kinase type II subunit delta ENSG00000145349 'CAMK2D intron_variant ENSG00000145349 ENSG00000145349 'CAMK2D 3 novel specific_pathway CAMK2D chr4 113418054 113761927 -1 817 protein_coding 4:113747320 14607 159_1_1 SeqId_15385_116 'FABP2 chr4:120263158_C_G$SeqId_15385_116 1 chr4:120263158_C_G rs9994354 cis 4 120263158 C G 0.2605 -1.0267 0.0117 6.76e-1675 'Fatty acid-binding protein, intestinal ENSG00000145384 'FABP2 intron_variant 0.997403 rs1799883 ENSG00000145384 'FABP2 missense_variant ENSG00000145384 ENSG00000145384 'FABP2 3 known suggestive_specific_pathway -0.47494 0.075539 7.25270478091247e-10 yes FABP2 Olink CARDIOVASCULAR II(v.5004) FABP2 chr4 119317250 119322138 -1 2169 protein_coding 4:119342003 19865 159_2_1 SeqId_16805_5 'PDE5A chr4:120559292_G_T$SeqId_16805_5 1 chr4:120559292_G_T rs6534149 cis 4 120559292 T G 0.377 0.2513 0.0134 2.11e-78 'cGMP-specific 3',5'-cyclic phosphodiesterase ENSG00000138735 'PDE5A intergenic_variant ENSG00000138735 ENSG00000138735 'PDE5A 3 known suggestive_specific_pathway PDE5A chr4 119494397 119628804 -1 8654 protein_coding 4:119638137 9333 159_2_1 SeqId_5256_86 'PDE5A chr4:120556467_C_T$SeqId_5256_86 1 chr4:120556467_C_T rs59867181 cis 4 120556467 T C 0.6229 -0.3448 0.0127 1.27e-162 'cGMP-specific 3',5'-cyclic phosphodiesterase ENSG00000138735 'PDE5A intergenic_variant ENSG00000138735 ENSG00000138735 'PDE5A 3 known suggestive_specific_pathway PDE5A chr4 119494397 119628804 -1 8654 protein_coding 4:119635312 6508 16_1_1 SeqId_8768_4 'Bcl-10 chr1:85744792_D_I$SeqId_8768_4 1 chr1:85744792_D_I rs75345056 cis 1 85744792 D I 0.0726 0.2191 0.0252 3.74e-18 'B-cell lymphoma/leukemia 10 ENSG00000142867 'BCL10 upstream_gene_variant ENSG00000142867 ENSG00000142867 'BCL10 3 novel specific_protein BCL10 chr1 85265776 85276632 -1 8915 protein_coding 1:85279110 2478 160_1_1 SeqId_14158_17 'Annexin V chr4:122616863_C_G$SeqId_14158_17 1 chr4:122616863_C_G rs9998908 cis 4 122616863 C G 0.0848 0.3818 0.0239 1.77e-57 'Annexin A5 ENSG00000164111 'ANXA5 intron_variant ENSG00000164111 ENSG00000164111 'ANXA5 3 novel specific_protein ANXA5 chr4 121667946 121696995 -1 308 protein_coding 4:121695708 1287 160_2_1 SeqId_3025_50 'bFGF chr4:123748616_C_G$SeqId_3025_50 1 chr4:123748616_C_G rs2922979 cis 4 123748616 C G 0.6903 0.719 0.013 8.29e-667 'Fibroblast growth factor 2 ENSG00000138685 'FGF2 intron_variant ENSG00000138685 ENSG00000138685 'FGF2 3 known specific_protein 0.93566 0.055948 6.98232404077173e-50 yes FGF2 Olink IMMUNE RESPONSE(v.3202) FGF2 chr4 122826708 122898236 1 2247 protein_coding 4:122827461 753 161_1_2 SeqId_10833_64 'HHIP chr4:145659064_C_T$SeqId_10833_64 1 chr4:145659064_C_T rs11727676 cis 4 145659064 T C 0.9022 -0.2459 0.0232 2.48e-26 'Hedgehog-interacting protein ENSG00000164161 'HHIP synonymous_variant ENSG00000164161 ENSG00000164161 'HHIP 3 novel specific_protein HHIP chr4 144646156 144745271 1 64399 protein_coding 4:144737912 91756 163_1_1 SeqId_13488_3 'ARFP1 chr4:153701130_C_T$SeqId_13488_3 1 chr4:153701130_C_T rs4619875 cis 4 153701130 T C 0.3999 0.3368 0.0125 5.18e-160 'Arfaptin-1 ENSG00000164144 'ARFIP1 5_prime_UTR_variant ENSG00000164144 ENSG00000164144 'ARFIP1 3 known specific_protein ARFIP1 chr4 152779937 152918463 1 27236 protein_coding 4:152779978 41 163_2_1 SeqId_4989_7 'Fibrinogen g-chain dimer chr4:155493171_A_G$SeqId_4989_7 1 chr4:155493171_A_G rs2227426 cis 4 155493171 A G 0.1788 0.1828 0.0171 1.28e-26 'Fibrinogen gamma chain ENSG00000171557 'FGG downstream_gene_variant 0.99695 rs4220 ENSG00000171564 'FGB missense_variant ENSG00000171557 ENSG00000171557|ENSG00000171560|ENSG00000171564 'FGA|FGB|FGG 3 known specific_pathway FGG chr4 154604134 154612967 -1 2266 protein_coding 4:154572019 40948 164_1_1 SeqId_9264_11 'CATO chr4:156856193_A_C$SeqId_9264_11 1 chr4:156856193_A_C rs2334114 cis 4 156856193 A C 0.2116 -0.1452 0.0158 3.18e-20 'Cathepsin O ENSG00000256043 'CTSO intron_variant ENSG00000256043 ENSG00000256043 'CTSO 3 novel specific_protein CTSO chr4 155921580 155953912 -1 1519 protein_coding 4:155935041 18871 164_2_1 SeqId_13658_31 'PDGF-CC chr4:157977619_A_G$SeqId_13658_31 1 chr4:157977619_A_G rs72494011 cis 4 157977619 A G 0.1647 0.153 0.0178 8.57e-18 'Platelet-derived growth factor C ENSG00000145431 'PDGFC intergenic_variant ENSG00000145431 ENSG00000145431 'PDGFC 3 novel specific_protein -0.21819 0.086175 0.0116627240508196 no PDGFC Olink ORGAN DAMAGE(v.3301) PDGFC chr4 156760454 156971799 -1 56034 protein_coding 4:157056467 84668 165_1_1 SeqId_5202_4 'PPID chr4:159637113_C_T$SeqId_5202_4 1 chr4:159637113_C_T rs17843929 cis 4 159637113 T C 0.2724 0.4909 0.0138 2.49e-276 'Peptidyl-prolyl cis-trans isomerase D ENSG00000171497 'PPID intron_variant 0.855563 rs9410 ENSG00000171497 'PPID missense_variant ENSG00000171497 ENSG00000171497 'PPID 3 known specific_protein PPID chr4 158709127 158723396 -1 5481 protein_coding 4:158715961 7435 166_1_1 SeqId_9906_21 'TICN3 chr4:168139859_A_G$SeqId_9906_21 1 chr4:168139859_A_G rs62353586 cis 4 168139859 A G 0.0231 1.2011 0.0457 1.41e-152 'Testican-3 ENSG00000196104 'SPOCK3 intron_variant ENSG00000196104 ENSG00000196104 'SPOCK3 3 known specific_protein SPOCK3 chr4 166733384 167234796 -1 50859 protein_coding 4:167218708 16088 167_1_1 SeqId_3132_1 'VEGF-C chr4:177638987_A_C$SeqId_3132_1 1 chr4:177638987_A_C rs112793547 cis 4 177638987 A C 0.9897 -0.5455 0.0637 1.11e-17 'Vascular endothelial growth factor C ENSG00000150630 'VEGFC intron_variant 0.970952 rs41278571 ENSG00000150630 'VEGFC missense_variant ENSG00000150630 ENSG00000150630 'VEGFC 3 known specific_protein -0.77047 0.28165 0.00645654229034656 yes VEGFC Olink ORGAN DAMAGE(v.3301) VEGFC chr4 176683538 176792922 -1 7424 protein_coding 4:176717833 75089 168_1_1 SeqId_17756_69 'DCTD chr4:183981702_D_I$SeqId_17756_69 1 chr4:183981702_D_I rs150825391 cis 4 183981702 D I 0.3372 0.121 0.0138 2.16e-18 'Deoxycytidylate deaminase ENSG00000129187 'DCTD intergenic_variant ENSG00000129187 ENSG00000129187 'DCTD 3 novel specific_protein DCTD chr4 182890060 182917936 -1 1635 protein_coding 4:183060550 142614 169_1_1 SeqId_15579_26 'ENPP6 chr4:185139101_C_T$SeqId_15579_26 1 chr4:185139101_C_T rs78293932 cis 4 185139101 T C 0.0256 0.3565 0.0428 8.39e-17 'Ectonucleotide pyrophosphatase/phosphodiesterase family member 6 ENSG00000164303 'ENPP6 5_prime_UTR_variant ENSG00000164303 ENSG00000164303 'ENPP6 3 novel specific_protein ENPP6 chr4 184088706 184221230 -1 133121 protein_coding 4:184217948 3282 169_1_2 SeqId_3593_72 'Caspase-3 chr4:185592134_D_I$SeqId_3593_72 1 chr4:185592134_D_I rs150986391 cis 4 185592134 D I 0.1224 -0.3213 0.0194 1.92e-61 'Caspase-3 ENSG00000164305 'CASP3 intron_variant ENSG00000164305 ENSG00000164305 'CASP3 3 known specific_protein -0.39795 0.092167 1.91425592502109e-05 yes CASP-3 Olink CARDIOVASCULAR III(v.6112) CASP3 chr4 184627696 184649509 -1 836 protein_coding 4:184670981 21472 17_1_1 SeqId_12682_5 'KAT3 chr1:89418403_C_T$SeqId_12682_5 1 chr1:89418403_C_T rs1409152 cis 1 89418403 T C 0.4985 -0.4176 0.0123 1.19e-250 'Kynurenine--oxoglutarate transaminase 3 ENSG00000137944 'CCBL2 intron_variant ENSG00000137944 ENSG00000137944 'KYAT3 3 known specific_protein KYAT3 chr1 88935773 88992953 -1 56267 protein_coding 1:88952720 40233 17_1_2 SeqId_15326_64 'GBP1 chr1:89530425_C_T$SeqId_15326_64 1 chr1:89530425_C_T rs12089335 cis 1 89530425 T C 0.3041 -0.1526 0.0144 3.98e-26 'Guanylate-binding protein 1 ENSG00000117228 'GBP1 intron_variant 0.998945 rs1048443 ENSG00000117228 'GBP1 missense_variant ENSG00000117228 ENSG00000117228 'GBP1 3 novel specific_protein GBP1 chr1 89051882 89065360 -1 2633 protein_coding 1:89064742 618 17_1_3 SeqId_18891_98 'GBP2 chr1:89553773_D_I$SeqId_18891_98 1 chr1:89553773_D_I rs34086227 cis 1 89553773 D I 0.213 -0.1742 0.0159 4.96e-28 'Guanylate-binding protein 2 ENSG00000162645 'GBP2 intergenic_variant ENSG00000162645 ENSG00000162645 'GBP2 3 novel specific_protein -0.1549 0.076875 0.0444631267469109 yes GBP2 Olink NEURO EXPLORATORY(v.3901) GBP2 chr1 89106132 89150456 -1 2634 protein_coding 1:89088091 62365 170_1_1 SeqId_4152_58 'Prekallikrein chr4:187161061_G_T$SeqId_4152_58 1 chr4:187161061_G_T rs71640035 cis 4 187161061 T G 0.5778 -0.5612 0.0127 1.74e-426 'Plasma kallikrein ENSG00000164344 'KLKB1 intron_variant 0.720727 rs3733402 ENSG00000164344 'KLKB1 missense_variant ENSG00000164344 ENSG00000164344 'KLKB1 6 known suggestive_specific_pathway KLKB1 chr4 186208979 186258471 1 3818 protein_coding 4:186239907 30928 170_1_2 SeqId_16918_198 'TLR3 chr4:187004074_C_T$SeqId_16918_198 1 chr4:187004074_C_T rs3775291 cis 4 187004074 T C 0.299 -0.8082 0.013 6.78e-842 'Toll-like receptor 3 ENSG00000164342 'TLR3 missense_variant ENSG00000164342 ENSG00000164342 'TLR3 3 novel specific_pathway -1.0613 0.046265 2.89734358770134e-79 yes TLR3 Olink ONCOLOGY II(v.7002) TLR3 chr4 186069155 186088073 1 7098 protein_coding 4:186082920 13765 170_1_3 SeqId_2190_55 'Coagulation Factor XI chr4:187207381_C_T$SeqId_2190_55 1 chr4:187207381_C_T rs2289252 cis 4 187207381 T C 0.4052 0.4622 0.0131 2.1e-272 'Coagulation Factor XI ENSG00000088926 'F11 intron_variant ENSG00000088926 ENSG00000088926 'F11 3 known suggestive_specific_pathway 0.40875 0.060635 4.48745389933131e-11 yes F11 Olink CARDIOMETABOLIC(v.3602) F11 chr4 186266189 186289681 1 2160 protein_coding 4:186286227 20038 171_1_1 SeqId_19488_1 'PDCD6 chr5:272057_C_T$SeqId_19488_1 1 chr5:272057_C_T rs62345187 cis 5 272057 T C 0.8833 0.1594 0.0208 1.76e-14 'Programmed cell death protein 6 ENSG00000249915 'PDCD6 intron_variant ENSG00000249915 ENSG00000249915 'PDCD6 3 novel specific_protein PDCD6 chr5 271621 314974 1 10016 protein_coding 5:271942 321 172_1_1 SeqId_13132_14 'SEM5A chr5:9547958_C_G$SeqId_13132_14 1 chr5:9547958_C_G rs17329324 cis 5 9547958 C G 0.9036 -1.5247 0.0173 1.92e-1689 'Semaphorin-5A ENSG00000112902 'SEMA5A upstream_gene_variant ENSG00000112902 ENSG00000112902 'SEMA5A 3 known specific_protein SEMA5A chr5 9035033 9546075 -1 9037 protein_coding 5:9547846 1771 172_2_1 SeqId_19115_13 'CMBL chr5:10307022_C_T$SeqId_19115_13 1 chr5:10307022_C_T rs11738492 cis 5 10307022 T C 0.6306 0.1646 0.0142 5.87e-31 'Carboxymethylenebutenolidase homolog ENSG00000164237 'CMBL intron_variant ENSG00000164237 ENSG00000164237 'CMBL 3 novel specific_protein CMBL chr5 10275875 10307902 -1 134147 protein_coding 5:10306910 992 174_1_1 SeqId_7251_64 'C1QT3 chr5:34018623_A_G$SeqId_7251_64 1 chr5:34018623_A_G rs840390 cis 5 34018623 A G 0.1302 -0.2837 0.0188 2.44e-51 'Complement C1q tumor necrosis factor-related protein 3 ENSG00000082196 'C1QTNF3 downstream_gene_variant ENSG00000082196 ENSG00000082196 'C1QTNF3 3 known specific_protein C1QTNF3 chr5 34017858 34043213 -1 114899 protein_coding 5:34018518 24695 175_1_1 SeqId_5089_11 'IL-7 Ra chr5:35866218_A_G$SeqId_5089_11 1 chr5:35866218_A_G rs6451229 cis 5 35866218 A G 0.5932 -0.1647 0.0135 4.83e-34 'Interleukin-7 receptor subunit alpha ENSG00000168685 'IL7R intron_variant 0.522443 rs3194051 ENSG00000168685 'IL7R missense_variant ENSG00000168685 ENSG00000168685 'IL7R 3 known specific_protein -0.47324 0.059241 1.0069316688518e-14 yes IL7R Olink CARDIOMETABOLIC(v.3602) IL7R chr5 35852695 35879603 1 3575 protein_coding 5:35866116 13421 176_1_1 SeqId_12338_27 'EGFLA chr5:38381406_A_G$SeqId_12338_27 1 chr5:38381406_A_G rs2589775 cis 5 38381406 A G 0.7673 0.1216 0.0154 2.69e-15 'Pikachurin ENSG00000164318 'EGFLAM intron_variant 0.211809 rs2561111 ENSG00000164318 'EGFLAM missense_variant ENSG00000164318 ENSG00000164318 'EGFLAM 3 novel specific_protein EGFLAM chr5 38258409 38465480 1 133584 protein_coding 5:38381304 122895 176_1_2 SeqId_5837_49 'LIF sR chr5:38496779_C_T$SeqId_5837_49 1 chr5:38496779_C_T rs3729741 cis 5 38496779 T C 0.3411 0.1111 0.0137 4.92e-16 'Leukemia inhibitory factor receptor ENSG00000113594 'LIFR intron_variant 0.148181 rs3110234 ENSG00000113594 'LIFR missense_variant ENSG00000113594 ENSG00000113594 'LIFR 3 known specific_protein LIFR chr5 38474668 38608354 -1 3977 protein_coding 5:38496677 111677 176_2_2 SeqId_10892_8 'OSMR chr5:39023193_A_C$SeqId_10892_8 1 chr5:39023193_A_C rs58330611 cis 5 39023193 A C 0.6024 0.2681 0.0135 5.23e-88 'Oncostatin-M-specific receptor subunit beta ENSG00000145623 'OSMR intron_variant ENSG00000145623 ENSG00000145623 'OSMR 3 known specific_protein -0.081718 0.064441 0.205371417181204 no OSMR Olink CARDIOMETABOLIC(v.3602) OSMR chr5 38845858 38945596 1 9180 protein_coding 5:39023091 177233 176_2_3 SeqId_3060_43 'C9 chr5:39356126_A_G$SeqId_3060_43 1 chr5:39356126_A_G rs696766 cis 5 39356126 A G 0.059 0.2959 0.0282 1.04e-25 'Complement component C9 ENSG00000113600 'C9 intron_variant ENSG00000113600 ENSG00000113600 'C9 3 novel specific_protein C9 chr5 39284140 39424868 -1 735 protein_coding 5:39356024 68844 176_3_1 SeqId_4127_75 'C6 chr5:41210195_A_T$SeqId_4127_75 1 chr5:41210195_A_T rs181908440 cis 5 41210195 A T 0.0123 -1.5384 0.0591 3.7e-149 'Complement component C6 ENSG00000039537 'C6 intron_variant 0.946793 rs41271067 ENSG00000039537 'C6 missense_variant ENSG00000039537 ENSG00000039537 'C6 6 novel suggestive_specific_pathway C6 chr5 41142116 41261438 -1 729 protein_coding 5:41210093 51345 176_3_2 SeqId_2888_49 'C7 chr5:40972211_A_G$SeqId_2888_49 1 chr5:40972211_A_G rs74480769 cis 5 40972211 A G 0.9698 1.2079 0.0388 3.31e-213 'Complement component C7 ENSG00000112936 'C7 intron_variant 0.105557 rs121964920 ENSG00000112936 'C7 missense_variant ENSG00000112936 ENSG00000112936 'C7 3 known unspecific_effect C7 chr5 40909497 40984643 1 730 protein_coding 5:40972109 62612 176_4_2 SeqId_2948_58 'Growth hormone receptor chr5:42738222_A_C$SeqId_2948_58 1 chr5:42738222_A_C rs10440652 cis 5 42738222 A C 0.4077 -0.2451 0.0143 9.9e-66 'Growth hormone receptor ENSG00000112964 'GHR regulatory_region_variant 0.674813 rs6180 ENSG00000112964 'GHR missense_variant ENSG00000112964 ENSG00000112964 'GHR 3 known unspecific_effect GHR chr5 42423439 42721878 1 2690 protein_coding 5:42738120 314681 177_1_1 SeqId_15603_20 'Integrin alpha-2 chr5:52252191_C_T$SeqId_15603_20 1 chr5:52252191_C_T rs7035 cis 5 52252191 T C 0.3171 0.1361 0.0152 4.11e-19 'Integrin alpha-2 ENSG00000164171 'ITGA2 3_prime_UTR_variant ENSG00000164171 ENSG00000164171 'ITGA2 3 novel specific_protein ITGA2 chr5 52989340 53094779 1 3673 protein_coding 5:52956361 32979 178_1_1 SeqId_3805_16 'Endocan chr5:54198775_C_T$SeqId_3805_16 1 chr5:54198775_C_T rs4242051 cis 5 54198775 T C 0.2469 -0.1467 0.0155 3.81e-21 'Endothelial cell-specific molecule 1 ENSG00000164283 'ESM1 intergenic_variant ENSG00000164283 ENSG00000164283 'ESM1 3 known specific_protein ESM1 chr5 54977867 55022671 -1 11082 protein_coding 5:54902947 119724 178_1_2 SeqId_9545_156 'Granzyme K chr5:54317900_C_T$SeqId_9545_156 1 chr5:54317900_C_T rs6891823 cis 5 54317900 T C 0.5573 0.1249 0.0131 1.3e-21 'Granzyme K ENSG00000113088 'GZMK upstream_gene_variant ENSG00000113088 ENSG00000113088 'GZMK 3 known specific_protein GZMK chr5 55024256 55034570 1 3003 protein_coding 5:55022072 2184 178_1_3 SeqId_2620_4 'gp130, soluble chr5:55263373_C_T$SeqId_2620_4 1 chr5:55263373_C_T rs11739016 cis 5 55263373 T C 0.1218 0.4526 0.0199 5.41e-114 'Interleukin-6 receptor subunit beta ENSG00000134352 'IL6ST intron_variant 0.997414 rs2228044 ENSG00000134352 'IL6ST missense_variant ENSG00000134352 ENSG00000134352 'IL6ST 3 known specific_protein IL6ST chr5 55935095 55995022 -1 3572 protein_coding 5:55967545 27477 18_1_1 SeqId_3009_3 'TGF-b R III chr1:92087039_A_T$SeqId_3009_3 1 chr1:92087039_A_T rs12135487 cis 1 92087039 A T 0.788 -0.1248 0.0163 2.33e-14 'Transforming growth factor beta receptor type 3 ENSG00000069702 'TGFBR3 intergenic_variant ENSG00000069702 ENSG00000069702 'TGFBR3 3 novel specific_protein TGFBR3 chr1 91680343 91906335 -1 7049 protein_coding 1:91621482 284853 18_2_1 SeqId_11277_23 'ATF6A chr1:93539383_A_G$SeqId_11277_23 1 chr1:93539383_A_G rs12385720 trans 1 93539383 A G 0.6315 -0.0994 0.0125 2.06e-15 'Cyclic AMP-dependent transcription factor ATF-6 alpha ENSG00000118217 'ATF6 intergenic_variant 0.969134 rs1060622 ENSG00000117500 'TMED5 missense_variant ENSG00000117500 ENSG00000117500 'TMED5 2 novel unspecific_effect ATF6 chr1 161766298 161977574 1 22926 protein_coding 1:93073826 68692472 18_2_2 SeqId_18214_2 'GSH0 chr1:94384624_A_G$SeqId_18214_2 1 chr1:94384624_A_G rs12563495 cis 1 94384624 A G 0.5034 -0.1017 0.0122 7.47e-17 'Glutamate--cysteine ligase regulatory subunit ENSG00000023909 'GCLM downstream_gene_variant ENSG00000023909 ENSG00000023909 'GCLM 3 novel specific_protein GCLM chr1 93885199 93909456 -1 2730 protein_coding 1:93919068 9612 180_1_1 SeqId_13535_2 'C43BP chr5:74740950_C_T$SeqId_13535_2 1 chr5:74740950_C_T rs9791146 cis 5 74740950 T C 0.0865 0.185 0.0221 6.7e-17 'Collagen type IV alpha-3-binding protein ENSG00000113163 'COL4A3BP intron_variant ENSG00000113163 ENSG00000113163 'CERT1 3 novel specific_protein CERT1 chr5 75356345 75512138 -1 10087 protein_coding 5:75445125 67013 180_1_1 SeqId_13950_9 'C43BP chr5:74740950_C_T$SeqId_13950_9 1 chr5:74740950_C_T rs9791146 cis 5 74740950 T C 0.0865 0.2213 0.0224 5.98e-23 'Collagen type IV alpha-3-binding protein ENSG00000113163 'COL4A3BP intron_variant ENSG00000113163 ENSG00000113163 'CERT1 3 novel specific_protein CERT1 chr5 75356345 75512138 -1 10087 protein_coding 5:75445125 67013 180_1_2 SeqId_15470_11 'Hexosaminidase B chr5:74030338_A_G$SeqId_15470_11 1 chr5:74030338_A_G rs13164140 cis 5 74030338 A G 0.2345 0.3255 0.0157 4.62e-95 'Beta-hexosaminidase subunit beta ENSG00000049860 'HEXB intron_variant 0.125638 rs11556045 ENSG00000049860 'HEXB missense_variant ENSG00000049860 ENSG00000049860 'HEXB 3 novel specific_protein HEXB chr5 74640023 74722647 1 3074 protein_coding 5:74734513 94490 180_2_1 SeqId_6039_24 'CRHBP chr5:76210859_A_G$SeqId_6039_24 1 chr5:76210859_A_G rs1700658 cis 5 76210859 A G 0.6427 -0.6606 0.0128 6.48e-581 'Corticotropin-releasing factor-binding protein ENSG00000145708 'CRHBP intron_variant ENSG00000145708 ENSG00000145708 'CRHBP 3 known specific_protein -0.53865 0.056908 1.28528665994362e-19 yes CRHBP Olink DEVELOPMENT(v.3511) CRHBP chr5 76953045 76981158 1 1393 protein_coding 5:76915034 38011 181_1_1 SeqId_3172_28 'ARSB chr5:78180482_C_T$SeqId_3172_28 1 chr5:78180482_C_T rs337835 cis 5 78180482 T C 0.6387 -0.2572 0.0138 1.81e-77 'Arylsulfatase B ENSG00000113273 'ARSB intron_variant 0.443998 rs1065757 ENSG00000113273 'ARSB missense_variant ENSG00000113273 ENSG00000113273 'ARSB 3 known specific_protein -0.21448 0.065687 0.00117192548866257 yes ARSB Olink CELL REGULATION(v.3701) ARSB chr5 78777209 78986087 -1 411 protein_coding 5:78884659 101428 181_1_3 SeqId_3340_53 'TSP4 chr5:79370247_G_T$SeqId_3340_53 1 chr5:79370247_G_T rs13167730 cis 5 79370247 T G 0.0976 0.4853 0.0218 7.5e-110 'Thrombospondin-4 ENSG00000113296 'THBS4 intron_variant ENSG00000113296 ENSG00000113296 'THBS4 3 known specific_protein 0.3809 0.10503 0.000317760565716129 yes THBS4 Olink CARDIOMETABOLIC(v.3602) THBS4 chr5 79991311 80083287 1 7060 protein_coding 5:80074424 83113 182_1_1 SeqId_18197_97 'KCRS chr5:80562348_C_T$SeqId_18197_97 1 chr5:80562348_C_T rs114173713 cis 5 80562348 T C 0.9782 -0.5131 0.0458 4.05e-29 'Creatine kinase S-type, mitochondrial ENSG00000131730 'CKMT2 downstream_gene_variant ENSG00000131730 ENSG00000131730 'CKMT2 3 novel specific_protein CKMT2 chr5 81233320 81266398 1 1160 protein_coding 5:81266529 33209 183_1_1 SeqId_9886_28 'XRCC4 chr5:82643365_A_G$SeqId_9886_28 1 chr5:82643365_A_G rs11953364 cis 5 82643365 A G 0.1093 0.1965 0.0201 1.55e-22 'DNA repair protein XRCC4 ENSG00000152422 'XRCC4 intron_variant 0.989757 rs1805377 ENSG00000152422 'XRCC4 splice_acceptor_variant ENSG00000152422 ENSG00000152422 'XRCC4 3 novel specific_protein XRCC4 chr5 83077498 83353787 1 7518 protein_coding 5:83347546 270048 183_1_2 SeqId_3196_6 'HPLN1 chr5:83010095_A_G$SeqId_3196_6 1 chr5:83010095_A_G rs975595 cis 5 83010095 A G 0.7545 0.1724 0.0157 4.41e-28 'Hyaluronan and proteoglycan link protein 1 ENSG00000145681 'HAPLN1 intron_variant ENSG00000145681 ENSG00000145681 'HAPLN1 3 known specific_protein HAPLN1 chr5 83637805 83720855 -1 1404 protein_coding 5:83714276 6579 184_1_1 SeqId_3196_6 'HPLN1 chr5:86266939_A_G$SeqId_3196_6 1 chr5:86266939_A_G rs12109445 trans 5 86266939 A G 0.618 -0.1126 0.0144 4.46e-15 'Hyaluronan and proteoglycan link protein 1 ENSG00000145681 'HAPLN1 intron_variant ENSG00000249061 ENSG00000249061 ' 1 novel specific_protein HAPLN1 chr5 83637805 83720855 -1 1404 protein_coding 5:86971122 3250267 184_1_2 SeqId_9848_22 'Cyclin H chr5:86735368_A_G$SeqId_9848_22 1 chr5:86735368_A_G rs62368956 cis 5 86735368 A G 0.2034 -0.1639 0.0166 5.37e-23 'Cyclin-H ENSG00000134480 'CCNH intergenic_variant 0.983386 rs2230641 ENSG00000134480 'CCNH missense_variant ENSG00000134480 ENSG00000134480 'CCNH 3 known specific_protein CCNH chr5 87318416 87412930 -1 902 protein_coding 5:87439551 26621 185_2_1 SeqId_17410_5 'CETN3 chr5:89750018_A_T$SeqId_17410_5 1 chr5:89750018_A_T rs6864721 cis 5 89750018 A T 0.2731 -0.1776 0.0146 6.22e-34 'Centrin-3 ENSG00000153140 'CETN3 downstream_gene_variant 0.995575 rs4873 ENSG00000153140 'CETN3 missense_variant ENSG00000153140 ENSG00000153140 'CETN3 3 novel specific_protein CETN3 chr5 90392257 90409766 -1 1070 protein_coding 5:90454201 44435 186_1_1 SeqId_5615_62 'F172A chr5:93051362_A_T$SeqId_5615_62 1 chr5:93051362_A_T rs35107028 cis 5 93051362 A T 0.1297 0.1694 0.0195 3.32e-18 'Protein FAM172A ENSG00000113391 'FAM172A intron_variant ENSG00000113391 ENSG00000113391 'FAM172A 3 novel specific_protein FAM172A chr5 93617725 94111699 -1 83989 protein_coding 5:93715656 396043 187_1_1 SeqId_8269_327 'ARSK chr5:94942780_C_T$SeqId_8269_327 1 chr5:94942780_C_T rs17084933 cis 5 94942780 T C 0.9585 0.3245 0.0333 1.74e-22 'Arylsulfatase K ENSG00000164291 'ARSK downstream_gene_variant 0.829323 rs17084927 ENSG00000164291 'ARSK missense_variant ENSG00000164291 ENSG00000164291 'ARSK 3 novel specific_protein ARSK chr5 95555101 95605102 1 153642 protein_coding 5:95607076 51975 187_1_2 SeqId_18386_36 'GLRX1 chr5:95161340_A_G$SeqId_18386_36 1 chr5:95161340_A_G rs6556884 cis 5 95161340 A G 0.2535 -0.2928 0.0152 1.71e-82 'Glutaredoxin-1 ENSG00000173221 'GLRX upstream_gene_variant ENSG00000173221 ENSG00000173221 'GLRX 3 novel unspecific_effect -0.21463 0.071576 0.00285167481430501 yes GLRX Olink METABOLISM(v.3402) GLRX chr5 95751319 95822726 -1 2745 protein_coding 5:95825636 2910 187_1_5 SeqId_13388_57 'NEC1 chr5:95729406_A_G$SeqId_13388_57 1 chr5:95729406_A_G rs13169290 cis 5 95729406 A G 0.273 -1.0678 0.0109 9.78e-2087 'Neuroendocrine convertase 1 ENSG00000175426 'PCSK1 intron_variant 0.997224 rs6235 ENSG00000175426 'PCSK1 missense_variant ENSG00000175426 ENSG00000175426 'PCSK1 3 known suggestive_specific_pathway PCSK1 chr5 96390333 96434143 -1 5122 protein_coding 5:96393702 40441 187_2_1 SeqId_8960_3 'LRAP chr5:96252432_A_G$SeqId_8960_3 1 chr5:96252432_A_G rs2927608 cis 5 96252432 A G 0.4396 1.1635 0.0077 5.40e-4961 'Endoplasmic reticulum aminopeptidase 2 ENSG00000164308 'ERAP2 intron_variant 0.797987 rs2549782 ENSG00000164308 'ERAP2 missense_variant ENSG00000164308 ENSG00000164308 'ERAP2 6 known unspecific_effect ERAP2 chr5 96875986 96919703 1 64167 protein_coding 5:96916728 40742 187_2_4 SeqId_4964_67 'ARTS1 chr5:96123160_C_T$SeqId_4964_67 1 chr5:96123160_C_T rs467735 cis 5 96123160 T C 0.216 1.2034 0.0115 1.16e-2380 'Endoplasmic reticulum aminopeptidase 1 ENSG00000164307 'ERAP1 intron_variant 0.668764 rs26653 ENSG00000164307 'ERAP1 missense_variant ENSG00000164307 ENSG00000164307 'ERAP1 3 known unspecific_effect ERAP1 chr5 96760810 96808100 -1 51752 protein_coding 5:96787457 20643 187_3_1 SeqId_3331_8 'RGMB chr5:97790915_D_I$SeqId_3331_8 1 chr5:97790915_D_I rs56411190 cis 5 97790915 D I 0.4509 -0.1643 0.0134 2.33e-34 'RGM domain family member B ENSG00000174136 'RGMB TF_binding_site_variant ENSG00000174136 ENSG00000174136 'RGMB 3 known specific_protein RGMB chr5 98768650 98798643 1 285704 protein_coding 5:98455212 313438 188_1_1 SeqId_6252_62 'Secretoglobin family 3A member 1 chr5:102125747_C_G$SeqId_6252_62 1 chr5:102125747_C_G rs2431322 trans 5 102125747 C G 0.6125 0.1333 0.0135 4.68e-23 'Secretoglobin family 3A member 1 ENSG00000161055 'SCGB3A1 intron_variant 0.443179 rs34813 ENSG00000145723 'GIN1 missense_variant ENSG00000145730 ENSG00000145730 'PAM 1 known suggestive_specific_pathway SCGB3A1 chr5 180590105 180591499 -1 92304 protein_coding 5:102790043 77801456 188_1_2 SeqId_5620_13 'AMD chr5:102338811_A_G$SeqId_5620_13 1 chr5:102338811_A_G rs35658696 cis 5 102338811 A G 0.9509 1.3439 0.0285 2.47e-485 'Peptidyl-glycine alpha-amidating monooxygenase ENSG00000145730 'PAM missense_variant ENSG00000145730 ENSG00000145730 'PAM 3 novel suggestive_specific_pathway 1.0828 0.1411 9.24698173938221e-14 yes PAM Olink CARDIOMETABOLIC(v.3602) PAM chr5 102753981 103029730 1 5066 protein_coding 5:103003107 249126 188_1_3 SeqId_13947_371 'NUD12 chr5:102866815_C_G$SeqId_13947_371 1 chr5:102866815_C_G rs6880267 cis 5 102866815 C G 0.84 1.036 0.0151 8.00e-1025 'Peroxisomal NADH pyrophosphatase NUDT12 ENSG00000112874 'NUDT12 intron_variant ENSG00000112874 ENSG00000112874 'NUDT12 3 known specific_protein NUDT12 chr5 103548855 103562790 -1 83594 protein_coding 5:103531114 31676 189_1_1 SeqId_2615_60 'Ephrin-A5 chr5:106938267_A_T$SeqId_2615_60 1 chr5:106938267_A_T rs6596742 cis 5 106938267 A T 0.4943 -0.0985 0.0127 7.64e-15 'Ephrin-A5 ENSG00000184349 'EFNA5 intron_variant ENSG00000184349 ENSG00000184349 'EFNA5 3 novel specific_pathway EFNA5 chr5 107376894 107670937 -1 1946 protein_coding 5:107602566 68371 19_2_1 SeqId_11143_32 'NOE3 chr1:102667388_A_G$SeqId_11143_32 1 chr1:102667388_A_G rs1938364 cis 1 102667388 A G 0.2285 -0.1673 0.0161 3.38e-25 'Noelin-3 ENSG00000118733 'OLFM3 intron_variant,non_coding_transcript_variant ENSG00000118733 ENSG00000118733 'OLFM3 3 novel specific_protein OLFM3 chr1 101802560 101996926 -1 118427 protein_coding 1:102201832 204906 19_3_1 SeqId_15556_49 'Alpha-amylase 2B chr1:104036684_C_T$SeqId_15556_49 1 chr1:104036684_C_T rs75199337 cis 1 104036684 T C 0.0943 0.6072 0.0228 9.09e-157 'Alpha-amylase 2B ENSG00000240038 'AMY2B intron_variant 0.157331 rs151132065 ENSG00000240038 'AMY2B missense_variant ENSG00000240038 ENSG00000240038 'AMY2B 3 novel specific_pathway AMY2B chr1 103553815 103579534 1 280 protein_coding 1:103494062 59753 19_3_3 SeqId_18917_53 'Pancreatic alpha-amylase chr1:104335726_G_T$SeqId_18917_53 1 chr1:104335726_G_T rs78245241 cis 1 104335726 T G 0.9684 1.1388 0.0383 1.53e-194 'Pancreatic alpha-amylase ENSG00000243480 'AMY2A intergenic_variant ENSG00000243480 ENSG00000243480 'AMY2A 3 known specific_pathway AMY2A chr1 103617427 103625780 1 279 protein_coding 1:103793104 175677 19_4_1 SeqId_5637_81 'NTNG1 chr1:107678268_C_G$SeqId_5637_81 1 chr1:107678268_C_G rs115668827 cis 1 107678268 C G 0.0472 1.4146 0.0283 4.38e-545 'Netrin-G1 ENSG00000162631 'NTNG1 upstream_gene_variant ENSG00000162631 ENSG00000162631 'NTNG1 3 known specific_protein NTNG1 chr1 107140007 107484923 1 22854 protein_coding 1:107135646 4361 190_1_1 SeqId_4220_39 'FER chr5:108080817_C_T$SeqId_4220_39 1 chr5:108080817_C_T rs6880917 cis 5 108080817 T C 0.3423 0.111 0.0135 2.34e-16 'Tyrosine-protein kinase Fer ENSG00000151422 'FER upstream_gene_variant ENSG00000151422 ENSG00000151422 'FER 3 novel specific_protein FER chr5 108747841 109196841 1 2241 protein_coding 5:108745116 2725 190_2_2 SeqId_17410_5 'CETN3 chr5:108641866_C_T$SeqId_17410_5 1 chr5:108641866_C_T rs7727299 trans 5 108641866 T C 0.3681 -0.0986 0.0134 2.11e-13 'Centrin-3 ENSG00000153140 'CETN3 intron_variant 0.830096 rs1045706 ENSG00000198961 'PJA2 missense_variant ENSG00000198961 ENSG00000198961 'PJA2 2 novel specific_protein CETN3 chr5 90392257 90409766 -1 1070 protein_coding 5:109306165 18896399 191_1_2 SeqId_5620_13 'AMD chr5:115346245_G_T$SeqId_5620_13 1 chr5:115346245_G_T rs17138646 trans 5 115346245 T G 0.8833 0.1831 0.021 2.84e-18 'Peptidyl-glycine alpha-amidating monooxygenase ENSG00000145730 'PAM intron_variant 0.595117 rs10078759 ENSG00000172901 'AQPEP missense_variant none none ' novel unspecific_effect 0.13871 0.096852 0.152749571284116 no PAM Olink CARDIOMETABOLIC(v.3602) PAM chr5 102753981 103029730 1 5066 protein_coding 5:116010548 13256567 192_1_1 SeqId_12563_2 'TFIP8 chr5:118641300_A_T$SeqId_12563_2 1 chr5:118641300_A_T rs1032859 cis 5 118641300 A T 0.8797 0.3201 0.0186 1.11e-66 'Tumor necrosis factor alpha-induced protein 8 ENSG00000145779 'TNFAIP8 downstream_gene_variant ENSG00000145779 ENSG00000145779 'TNFAIP8 3 novel suggestive_specific_pathway TNFAIP8 chr5 119268692 119399688 1 25816 protein_coding 5:119305605 36913 193_1_2 SeqId_18819_21 'PPIC chr5:122360403_C_T$SeqId_18819_21 1 chr5:122360403_C_T rs17388251 cis 5 122360403 T C 0.6233 0.6366 0.0122 8.68e-594 'Peptidyl-prolyl cis-trans isomerase C ENSG00000168938 'PPIC intron_variant 0.852709 rs451195 ENSG00000168938 'PPIC missense_variant ENSG00000168938 ENSG00000168938 'PPIC 3 novel unspecific_effect PPIC chr5 123023250 123036725 -1 5480 protein_coding 5:123024708 12017 194_1_1 SeqId_9468_8 'Lectin, mannose-binding 2 chr5:126904532_C_G$SeqId_9468_8 1 chr5:126904532_C_G rs145904643 trans 5 126904532 C G 0.0247 0.3586 0.0436 1.95e-16 'Vesicular integral-membrane protein VIP36 ENSG00000169223 'LMAN2 intergenic_variant none none ' novel specific_protein LMAN2 chr5 177331567 177351668 -1 10960 protein_coding 5:127568840 49782828 195_1_1 SeqId_9816_37 'ISOC1 chr5:128288602_C_G$SeqId_9816_37 1 chr5:128288602_C_G rs34942382 cis 5 128288602 C G 0.7052 -0.2945 0.0139 3.29e-99 'Isochorismatase domain-containing protein 1 ENSG00000066583 'ISOC1 intron_variant ENSG00000066583 ENSG00000066583 'ISOC1 3 novel specific_protein ISOC1 chr5 129094749 129114028 1 51015 protein_coding 5:128952909 141840 196_1_1 SeqId_5900_11 'HINT1 chr5:130474409_G_T$SeqId_5900_11 1 chr5:130474409_G_T rs6889109 cis 5 130474409 T G 0.7525 -0.1141 0.0149 2.14e-14 'Histidine triad nucleotide-binding protein 1 ENSG00000169567 'HINT1 intergenic_variant ENSG00000169567 ENSG00000169567 'HINT1 3 known unspecific_effect HINT1 chr5 131155383 131224468 -1 3094 protein_coding 5:131138716 85752 196_1_3 SeqId_12387_7 'PDLI4 chr5:131607588_G_T$SeqId_12387_7 1 chr5:131607588_G_T rs4877 cis 5 131607588 T G 0.0919 -0.4954 0.0228 1.8e-104 'PDZ and LIM domain protein 4 ENSG00000131435 'PDLIM4 missense_variant ENSG00000131435 ENSG00000131435 'PDLIM4 3 known specific_protein PDLIM4 chr5 132257696 132273454 1 8572 protein_coding 5:132271895 14199 196_2_2 SeqId_5708_1 'LEAP2 chr5:132203952_A_G$SeqId_5708_1 1 chr5:132203952_A_G rs55767930 cis 5 132203952 A G 0.1662 0.3752 0.0171 8.67e-107 'Liver-expressed antimicrobial peptide 2 ENSG00000164406 'LEAP2 upstream_gene_variant ENSG00000164406 ENSG00000164406 'LEAP2 3 known suggestive_specific_pathway LEAP2 chr5 132873444 132875046 1 116842 protein_coding 5:132868260 5184 196_2_4 SeqId_9350_3 'FSTL4 chr5:132533063_A_T$SeqId_9350_3 1 chr5:132533063_A_T rs3749820 cis 5 132533063 A T 0.7849 0.1932 0.0164 3.57e-32 'Follistatin-related protein 4 ENSG00000053108 'FSTL4 3_prime_UTR_variant 0.99372 rs3749817 ENSG00000053108 'FSTL4 missense_variant ENSG00000053108 ENSG00000053108 'FSTL4 3 novel specific_protein FSTL4 chr5 133196455 133612541 -1 23105 protein_coding 5:133197371 415170 196_2_5 SeqId_6366_38 'TXD15 chr5:134306890_C_T$SeqId_6366_38 1 chr5:134306890_C_T rs77625575 cis 5 134306890 T C 0.1275 0.3211 0.0197 1.34e-59 'Thioredoxin domain-containing protein 15 ENSG00000113621 'TXNDC15 intron_variant ENSG00000113621 ENSG00000113621 'TXNDC15 3 known specific_protein TXNDC15 chr5 134874371 134901635 1 79770 protein_coding 5:134971200 96829 196_3_1 SeqId_16763_11 'LECT2 chr5:135313633_A_T$SeqId_16763_11 1 chr5:135313633_A_T rs2428665 cis 5 135313633 A T 0.4347 -0.7276 0.0117 2.11e-842 'Leukocyte cell-derived chemotaxin-2 ENSG00000145826 'LECT2 regulatory_region_variant 0.448946 rs31517 ENSG00000145826 'LECT2 missense_variant ENSG00000145826 ENSG00000145826 'LECT2 3 known suggestive_specific_pathway LECT2 chr5 135922279 135954983 -1 3950 protein_coding 5:135977944 22961 196_3_2 SeqId_3283_21 'BGH3 chr5:135389433_C_T$SeqId_3283_21 1 chr5:135389433_C_T rs13159365 cis 5 135389433 T C 0.5179 -0.5608 0.0116 4.97e-510 'Transforming growth factor-beta-induced protein ig-h3 ENSG00000120708 'TGFBI intron_variant ENSG00000120708 ENSG00000120708 'TGFBI 3 known suggestive_specific_pathway -0.44878 0.058992 1.46892627764387e-13 yes TGFBI Olink CARDIOMETABOLIC(v.3602) TGFBI chr5 136028988 136063818 1 7045 protein_coding 5:136053744 24756 196_3_4 SeqId_5834_18 'IL-9 chr5:135479348_A_C$SeqId_5834_18 1 chr5:135479348_A_C rs6596287 cis 5 135479348 A C 0.6972 -0.1412 0.0148 1.9e-21 'Interleukin-9 ENSG00000145839 'IL9 intron_variant ENSG00000145839 ENSG00000145839 'IL9 3 known suggestive_specific_pathway IL9 chr5 135892246 135895841 -1 3578 protein_coding 5:136143659 247818 196_4_1 SeqId_16322_10 'PACAP chr5:138725772_D_I$SeqId_16322_10 1 chr5:138725772_D_I rs140248321 cis 5 138725772 D I 0.9291 -0.2974 0.0294 5.44e-24 'Marginal zone B- and B1-cell-specific protein ENSG00000170476 'MZB1 upstream_gene_variant ENSG00000170476 ENSG00000170476 'MZB1 3 novel specific_protein MZB1 chr5 139387467 139390081 -1 51237 protein_coding 5:139390084 3 196_5_1 SeqId_16914_104 'sCD14 chr5:140013567_G_T$SeqId_16914_104 1 chr5:140013567_G_T rs5744454 cis 5 140013567 T G 0.7611 0.219 0.0144 1.85e-52 'Monocyte differentiation antigen CD14, soluble ENSG00000170458 'CD14 upstream_gene_variant ENSG00000170458 ENSG00000170458 'CD14 3 known unspecific_effect CD14 chr5 140631728 140633701 -1 929 protein_coding 5:140633982 281 196_5_1 SeqId_8969_49 'CD14 chr5:140016847_A_G$SeqId_8969_49 1 chr5:140016847_A_G rs5744441 cis 5 140016847 A G 0.2311 -0.2808 0.0155 2.1e-73 'Monocyte differentiation antigen CD14 ENSG00000170458 'CD14 upstream_gene_variant ENSG00000170458 ENSG00000170458 'CD14 3 known unspecific_effect CD14 chr5 140631728 140633701 -1 929 protein_coding 5:140637262 3561 196_5_2 SeqId_18220_141 'SRA1 chr5:139953189_C_T$SeqId_18220_141 1 chr5:139953189_C_T rs801458 cis 5 139953189 T C 0.4704 0.1793 0.0124 2.64e-47 'Steroid receptor RNA activator 1 ENSG00000213523 'SRA1 downstream_gene_variant 0.993172 rs5871740 ENSG00000213523 'SRA1 frameshift_variant ENSG00000213523 ENSG00000213523 'SRA1 3 known specific_protein SRA1 chr5 140537340 140557677 -1 10011 protein_coding 5:140573604 15927 196_6_1 SeqId_8909_77 'GNPI1 chr5:141396566_C_T$SeqId_8909_77 1 chr5:141396566_C_T rs9324861 cis 5 141396566 T C 0.152 0.3186 0.0189 9.96e-64 'Glucosamine-6-phosphate isomerase 1 ENSG00000113552 'GNPDA1 upstream_gene_variant ENSG00000113552 ENSG00000113552 'GNPDA1 3 novel specific_protein GNPDA1 chr5 141991749 142013041 -1 10007 protein_coding 5:142017001 3960 197_1_1 SeqId_8243_55 'TATI chr5:147203817_C_G$SeqId_8243_55 1 chr5:147203817_C_G rs3777125 cis 5 147203817 C G 0.6029 -0.1241 0.0136 8.51e-20 'Serine protease inhibitor Kazal-type 1 ENSG00000164266 'SPINK1 downstream_gene_variant ENSG00000164266 ENSG00000164266 'SPINK1 3 known specific_protein -0.34231 0.062359 6.52228842465639e-08 yes SPINK1 Olink DEVELOPMENT(v.3511) SPINK1 chr5 147824572 147831671 -1 6690 protein_coding 5:147824254 7417 197_1_2 SeqId_8028_22 'SPINK5 chr5:147519527_A_T$SeqId_8028_22 1 chr5:147519527_A_T rs4371740 cis 5 147519527 A T 0.6271 0.1313 0.0134 1.63e-22 'Serine protease inhibitor Kazal-type 5 ENSG00000133710 'SPINK5 downstream_gene_variant 0.981477 rs3777134 ENSG00000133710 'SPINK5 missense_variant ENSG00000133710 ENSG00000133710 'SPINK5 3 known specific_pathway 0.36382 0.062497 1.0634081880997e-08 yes SPINK5 Olink DEVELOPMENT(v.3511) SPINK5 chr5 148025683 148137382 1 11005 protein_coding 5:148139964 114281 197_1_3 SeqId_5731_1 'ISK6 chr5:147619072_A_C$SeqId_5731_1 1 chr5:147619072_A_C rs1159203 cis 5 147619072 A C 0.0758 -1.1468 0.023 2.25e-542 'Serine protease inhibitor Kazal-type 6 ENSG00000178172 'SPINK6 intron_variant 0.999187 rs12186491 ENSG00000178172 'SPINK6 missense_variant ENSG00000178172 ENSG00000178172 'SPINK6 3 known specific_protein SPINK6 chr5 148202794 148215137 1 404203 protein_coding 5:148239509 36715 197_1_4 SeqId_10974_20 'ISK7 chr5:147823506_C_G$SeqId_10974_20 1 chr5:147823506_C_G rs79930019 cis 5 147823506 C G 0.9894 1.1114 0.0635 1.4e-68 'Serine protease inhibitor Kazal-type 7 ENSG00000145879 'SPINK7 downstream_gene_variant ENSG00000145879 ENSG00000145879 'SPINK7 3 novel specific_protein SPINK7 chr5 148312419 148315922 1 84651 protein_coding 5:148443943 131524 197_1_5 SeqId_13578_98 'ABLM3 chr5:148533724_A_G$SeqId_13578_98 1 chr5:148533724_A_G rs114464628 cis 5 148533724 A G 0.0369 -0.4446 0.0335 3.64e-40 'Actin-binding LIM protein 3 ENSG00000173210 'ABLIM3 intron_variant ENSG00000173210 ENSG00000173210 'ABLIM3 3 novel specific_protein ABLIM3 chr5 149141483 149260542 1 22885 protein_coding 5:149154161 12678 197_2_1 SeqId_3499_77 'IL-17B chr5:148783690_A_C$SeqId_3499_77 1 chr5:148783690_A_C rs6862301 cis 5 148783690 A C 0.3071 0.1316 0.0146 2.18e-19 'Interleukin-17B ENSG00000127743 'IL17B upstream_gene_variant ENSG00000127743 ENSG00000127743 'IL17B 3 novel specific_protein IL17B chr5 149371324 149404202 -1 27190 protein_coding 5:149404127 75 197_2_2 SeqId_13682_47 'M-CSF R chr5:149489606_A_C$SeqId_13682_47 1 chr5:149489606_A_C rs572474264 cis 5 149489606 A C 0.0148 -0.8206 0.0581 3.0e-45 'Macrophage colony-stimulating factor 1 receptor ENSG00000182578 'CSF1R intron_variant 0.418866 rs56048668 ENSG00000182578 'CSF1R missense_variant ENSG00000182578 ENSG00000182578 'CSF1R 3 known specific_pathway CSF1R chr5 150053291 150113372 -1 1436 protein_coding 5:150110043 3329 197_2_3 SeqId_3459_49 'PDGF Rb chr5:149508544_C_G$SeqId_3459_49 1 chr5:149508544_C_G rs2304058 cis 5 149508544 C G 0.441 -1.1426 0.008 1.46e-4432 'Platelet-derived growth factor receptor beta ENSG00000113721 'PDGFRB intron_variant ENSG00000113721 ENSG00000113721 'PDGFRB 3 known specific_protein -1.0452 0.041534 5.72796030985823e-90 yes PDGFRB Olink DEVELOPMENT(v.3511) PDGFRB chr5 150113839 150155872 -1 5159 protein_coding 5:150128981 26891 197_2_4 SeqId_6927_7 'NDST1 chr5:149937956_A_G$SeqId_6927_7 1 chr5:149937956_A_G rs253293 cis 5 149937956 A G 0.591 -0.1854 0.0134 3.04e-43 'Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 ENSG00000070614 'NDST1 downstream_gene_variant ENSG00000070614 ENSG00000070614 'NDST1 3 known specific_protein NDST1 chr5 150485818 150558211 1 3340 protein_coding 5:150558394 72576 197_3_1 SeqId_15441_6 'SAP3 chr5:150648242_D_I$SeqId_15441_6 1 chr5:150648242_D_I rs35654352 cis 5 150648242 D I 0.652 -0.385 0.0139 4.91e-168 'Ganglioside GM2 activator ENSG00000196743 'GM2A 3_prime_UTR_variant 0.281249 rs153477 ENSG00000196743 'GM2A missense_variant ENSG00000196743 ENSG00000196743 'GM2A 3 novel specific_protein GM2A chr5 151212150 151270440 1 2760 protein_coding 5:151268682 56532 197_3_3 SeqId_19233_75 'ATOX1 chr5:151195933_C_T$SeqId_19233_75 1 chr5:151195933_C_T rs2915894 cis 5 151195933 T C 0.4199 -0.0946 0.0134 2.05e-12 'Copper transport protein ATOX1 ENSG00000177556 'ATOX1 downstream_gene_variant 0.469575 rs6890099 ENSG00000177556 'ATOX1 splice_donor_variant ENSG00000177556 ENSG00000177556 'ATOX1 3 novel specific_protein ATOX1 chr5 151742316 151772532 -1 475 protein_coding 5:151816372 43840 198_1_1 SeqId_15449_33 'TIM-4 chr5:156396003_C_T$SeqId_15449_33 1 chr5:156396003_C_T rs12657266 cis 5 156396003 T C 0.6349 -0.217 0.0139 1.05e-54 'T-cell immunoglobulin and mucin domain-containing protein 4 ENSG00000145850 'TIMD4 intergenic_variant 0.145167 rs6873053 ENSG00000145850 'TIMD4 missense_variant ENSG00000145850 ENSG00000145850 'TIMD4 3 known unspecific_effect -0.21838 0.065116 0.000860201112713024 yes TIMD4 Olink CARDIOMETABOLIC(v.3602) TIMD4 chr5 156919292 156963226 -1 91937 protein_coding 5:156968992 5766 198_1_2 SeqId_9021_1 'TIM-1 chr5:156471069_A_G$SeqId_9021_1 1 chr5:156471069_A_G rs6878069 cis 5 156471069 A G 0.5096 0.3489 0.0124 3.72e-175 'Hepatitis A virus cellular receptor 1 ENSG00000113249 'HAVCR1 intron_variant 0.257841 rs45439103 ENSG00000113249 'HAVCR1 inframe_insertion ENSG00000113249 ENSG00000113249 'HAVCR1 3 known unspecific_effect 0.55662 0.053645 6.72976656284317e-23 yes KIM1 Olink CARDIOVASCULAR II(v.5004) HAVCR1 chr5 157029413 157059119 -1 26762 protein_coding 5:157044058 15061 198_1_3 SeqId_5134_52 'TIMD3 chr5:156532236_C_T$SeqId_5134_52 1 chr5:156532236_C_T rs7442742 cis 5 156532236 T C 0.1817 0.75 0.0154 1.52e-517 'Hepatitis A virus cellular receptor 2 ENSG00000135077 'HAVCR2 intron_variant 0.999245 rs1036199 ENSG00000135077 'HAVCR2 missense_variant ENSG00000135077 ENSG00000135077 'HAVCR2 3 known suggestive_specific_pathway -0.03609 0.078369 0.645356962727405 no HAVCR2 Olink DEVELOPMENT(v.3511) HAVCR2 chr5 157085832 157142869 -1 84868 protein_coding 5:157105225 37644 198_2_2 SeqId_13733_5 'IL-12 p40 chr5:158773117_A_G$SeqId_13733_5 1 chr5:158773117_A_G rs4244437 cis 5 158773117 A G 0.687 0.4884 0.0135 5.85e-286 'Interleukin-12 subunit beta ENSG00000113302 'IL12B intron_variant ENSG00000113302 ENSG00000110944|ENSG00000113302 'IL12B|IL23A 3 known unspecific_effect 0.51353 0.063065 3.34195040026114e-15 yes IL-12B Olink INFLAMMATION(v.3012) IL12B chr5 159314780 159330487 -1 3593 protein_coding 5:159346109 15622 198_2_2 SeqId_10365_132 'IL-23 chr5:158773117_A_G$SeqId_10365_132 1 chr5:158773117_A_G rs4244437 cis 5 158773117 A G 0.687 0.4083 0.0136 2.86e-197 'Interleukin-23 ENSG00000113302|ENSG00000110944 'IL12B|IL23A intron_variant ENSG00000113302|ENSG00000110944 ENSG00000110944|ENSG00000113302 'IL12B|IL23A 3 known unspecific_effect IL12B chr5 159314780 159330487 -1 3593 protein_coding 5:159346109 15622 198_2_3 SeqId_18215_5 'THG1 chr5:157164962_C_T$SeqId_18215_5 1 chr5:157164962_C_T rs2270812 cis 5 157164962 T C 0.3453 -0.3694 0.0135 1.26e-165 'Probable tRNA(His) guanylyltransferase ENSG00000113272 'THG1L missense_variant ENSG00000113272 ENSG00000113272 'THG1L 3 novel specific_protein THG1L chr5 157731420 157741449 1 54974 protein_coding 5:157737954 6534 198_2_4 SeqId_19124_9 'UBCP1 chr5:158690030_A_G$SeqId_19124_9 1 chr5:158690030_A_G rs71593333 cis 5 158690030 A G 0.0113 -0.6262 0.0659 2.09e-21 'Ubiquitin-like domain-containing CTD phosphatase 1 ENSG00000164332 'UBLCP1 upstream_gene_variant ENSG00000164332 ENSG00000164332 'UBLCP1 3 novel specific_protein UBLCP1 chr5 159263290 159286036 1 134510 protein_coding 5:159263022 268 2_1_1 SeqId_10015_119 'KCAB2 chr1:6052581_A_G$SeqId_10015_119 1 chr1:6052581_A_G rs806109 cis 1 6052581 A G 0.756 0.1924 0.0143 2.77e-41 'Voltage-gated potassium channel subunit beta-2 ENSG00000069424 'KCNAB2 upstream_gene_variant ENSG00000069424 ENSG00000069424 'KCNAB2 3 novel specific_protein KCNAB2 chr1 5990927 6101193 1 8514 protein_coding 1:5992521 1594 20_1_1 SeqId_3332_57 'RGM-C chr1:109818530_C_T$SeqId_3332_57 1 chr1:109818530_C_T rs646776 trans 1 109818530 T C 0.7771 0.2674 0.016 1.59e-62 'Hemojuvelin ENSG00000168509 'HFE2 downstream_gene_variant 0.137368 rs72703203 ENSG00000143126 'CELSR2 missense_variant ENSG00000134243 ENSG00000134243 'SORT1 3 known unspecific_effect HJV chr1 146017468 146036746 -1 148738 protein_coding 1:109275908 36760838 20_1_1 SeqId_3470_1 'sE-Selectin chr1:109817192_A_G$SeqId_3470_1 1 chr1:109817192_A_G rs7528419 trans 1 109817192 A G 0.7769 0.1365 0.016 1.21e-17 'E-selectin ENSG00000007908 'SELE 3_prime_UTR_variant 0.136788 rs72703203 ENSG00000143126 'CELSR2 missense_variant ENSG00000065135|ENSG00000143106 ENSG00000134243 'SORT1 3 known unspecific_effect SELE chr1 169722640 169764705 -1 6401 protein_coding 1:109274570 60490135 20_1_2 SeqId_15395_15 'GST M1-1 chr1:110229787_C_T$SeqId_15395_15 1 chr1:110229787_C_T rs36209093 cis 1 110229787 T C 0.6453 -0.8852 0.0144 3.55e-823 'Glutathione S-transferase Mu 1 ENSG00000134184 'GSTM1 upstream_gene_variant 0.15374 rs74837985 ENSG00000134184 'GSTM1 missense_variant ENSG00000134184 ENSG00000134184|ENSG00000168765 'GSTM1|GSTM4 3 known specific_pathway GSTM1 chr1 109687814 109709039 1 2944 protein_coding 1:109687165 649 20_1_2 SeqId_18895_54 'GSTM4 chr1:110229787_C_T$SeqId_18895_54 1 chr1:110229787_C_T rs36209093 cis 1 110229787 T C 0.6452 -0.9082 0.0141 1.54e-903 'Glutathione S-transferase Mu 4 ENSG00000168765 'GSTM4 upstream_gene_variant 0.15374 rs74837985 ENSG00000134184 'GSTM1 missense_variant ENSG00000168765 ENSG00000134184|ENSG00000168765 'GSTM1|GSTM4 3 known specific_pathway GSTM4 chr1 109656099 109674836 1 2948 protein_coding 1:109687165 31066 20_1_4 SeqId_9748_31 'GSTM3-3 chr1:110254513_C_G$SeqId_9748_31 1 chr1:110254513_C_G rs28743105 cis 1 110254513 C G 0.6697 0.8307 0.0126 1.72e-946 'Glutathione S-transferase Mu 3 ENSG00000134202 'GSTM3 upstream_gene_variant 0.575238 rs7483 ENSG00000134202 'GSTM3 missense_variant ENSG00000134202 ENSG00000134202 'GSTM3 3 novel specific_pathway GSTM3 chr1 109733932 109741038 -1 2947 protein_coding 1:109711891 29147 201_1_2 SeqId_9468_8 'Lectin, mannose-binding 2 chr5:176760852_D_I$SeqId_9468_8 1 chr5:176760852_D_I rs10569400 cis 5 176760852 D I 0.3133 0.136 0.0147 2.88e-20 'Vesicular integral-membrane protein VIP36 ENSG00000169223 'LMAN2 intron_variant ENSG00000169223 ENSG00000169223 'LMAN2 3 known unspecific_effect LMAN2 chr5 177331567 177351668 -1 10960 protein_coding 5:177333852 17816 201_1_4 SeqId_7806_33 'B4GT7 chr5:177180958_C_T$SeqId_7806_33 1 chr5:177180958_C_T rs7735142 cis 5 177180958 T C 0.9592 -0.3108 0.0363 1.01e-17 'Beta-1,4-galactosyltransferase 7 ENSG00000027847 'B4GALT7 intron_variant ENSG00000027847 ENSG00000027847 'B4GALT7 3 novel specific_pathway B4GALT7 chr5 177600132 177610330 1 11285 protein_coding 5:177753957 153825 201_2_1 SeqId_8894_80 'hnRNP A/B chr5:177606419_A_G$SeqId_8894_80 1 chr5:177606419_A_G rs6897795 cis 5 177606419 A G 0.1117 0.1633 0.0202 6.8e-16 'Heterogeneous nuclear ribonucleoprotein A/B ENSG00000197451 'HNRNPAB intergenic_variant ENSG00000197451 ENSG00000197451 'HNRNPAB 3 novel suggestive_specific_pathway HNRNPAB chr5 178204533 178211163 1 3182 protein_coding 5:178179418 25115 202_1_1 SeqId_7141_21 'MGT4B chr5:179228377_A_G$SeqId_7141_21 1 chr5:179228377_A_G rs113756550 cis 5 179228377 A G 0.0227 -1.2628 0.042 2.41e-198 'Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B ENSG00000161013 'MGAT4B missense_variant ENSG00000161013 ENSG00000161013 'MGAT4B 3 known specific_protein MGAT4B chr5 179797597 179806952 -1 11282 protein_coding 5:179801377 5575 202_2_1 SeqId_15604_18 'JNK2 chr5:179740366_C_T$SeqId_15604_18 1 chr5:179740366_C_T rs113096165 cis 5 179740366 T C 0.1997 0.2821 0.0158 3.72e-71 'Mitogen-activated protein kinase 9 ENSG00000050748 'MAPK9 intron_variant ENSG00000050748 ENSG00000050748 'MAPK9 3 known specific_protein MAPK9 chr5 180233143 180292099 -1 5601 protein_coding 5:180313366 21267 202_2_2 SeqId_6252_62 'Secretoglobin family 3A member 1 chr5:180019237_C_T$SeqId_6252_62 1 chr5:180019237_C_T rs307802 cis 5 180019237 T C 0.5942 -0.1398 0.0136 1.19e-24 'Secretoglobin family 3A member 1 ENSG00000161055 'SCGB3A1 upstream_gene_variant ENSG00000161055 ENSG00000161055 'SCGB3A1 3 known specific_protein -0.15545 0.063066 0.0140540016438762 yes SCGB3A1 Olink DEVELOPMENT(v.3511) SCGB3A1 chr5 180590105 180591499 -1 92304 protein_coding 5:180592237 738 202_2_3 SeqId_16035_8 'VEGF sR3 chr5:180032500_C_G$SeqId_16035_8 1 chr5:180032500_C_G rs1565818 cis 5 180032500 C G 0.108 -0.1699 0.0213 1.36e-15 'Vascular endothelial growth factor receptor 3 ENSG00000037280 'FLT4 intron_variant 0.979482 rs1130379 ENSG00000037280 'FLT4 missense_variant ENSG00000037280 ENSG00000037280 'FLT4 3 known specific_protein -0.41936 0.091808 6.26613864672335e-06 yes VEGFR-3 Olink ONCOLOGY II(v.7002) FLT4 chr5 180601506 180649624 -1 2324 protein_coding 5:180605500 44124 202_2_4 SeqId_7950_142 'BTNL9 chr5:180349778_C_T$SeqId_7950_142 1 chr5:180349778_C_T rs138692142 cis 5 180349778 T C 0.0105 -0.618 0.0738 5.43e-17 'Butyrophilin-like protein 9 ENSG00000165810 'BTNL9 intron_variant 0.813569 rs367635312 ENSG00000165810 'BTNL9 frameshift_variant ENSG00000165810 ENSG00000165810 'BTNL9 3 novel specific_protein BTNL9 chr5 181040225 181061521 1 153579 protein_coding 5:180922778 117447 202_2_5 SeqId_9026_40 'BTNL8 chr5:180376489_D_I$SeqId_9026_40 1 chr5:180376489_D_I rs201210185 cis 5 180376489 D I 0.8899 -0.3579 0.0218 1.8e-60 'Butyrophilin-like protein 8 ENSG00000113303 'BTNL8 intron_variant 0.860478 rs113820381 ENSG00000113303 'BTNL8 missense_variant ENSG00000113303 ENSG00000113303 'BTNL8 3 novel specific_protein BTNL8 chr5 180899077 180950906 1 79908 protein_coding 5:180949490 50413 204_2_2 SeqId_10737_96 'Serpin B1 chr6:2836873_D_I$SeqId_10737_96 1 chr6:2836873_D_I rs141437002 cis 6 2836873 D I 0.5489 0.0885 0.0128 5.63e-12 'Leukocyte elastase inhibitor ENSG00000021355 'SERPINB1 intron_variant ENSG00000021355 ENSG00000021355 'SERPINB1 3 novel specific_protein SERPINB1 chr6 2832332 2841959 -1 1992 protein_coding 6:2836640 5319 204_2_3 SeqId_9754_33 'Quinone reductase 2 chr6:3003970_A_G$SeqId_9754_33 1 chr6:3003970_A_G rs138616686 cis 6 3003970 A G 0.693 0.8075 0.0133 4.62e-803 'Ribosyldihydronicotinamide dehydrogenase [quinone] ENSG00000124588 'NQO2 5_prime_UTR_variant 0.109796 rs1143684 ENSG00000124588 'NQO2 missense_variant ENSG00000124588 ENSG00000124588 'NQO2 3 known specific_protein 0.67613 0.063611 7.44731973905989e-24 yes NQO2 Olink METABOLISM(v.3402) NQO2 chr6 2987987 3019755 1 4835 protein_coding 6:3003736 15749 204_2_4 SeqId_17813_21 'BPHL chr6:3151103_A_G$SeqId_17813_21 1 chr6:3151103_A_G rs3799219 cis 6 3151103 A G 0.9492 -0.9267 0.0281 5.1e-238 'Valacyclovir hydrolase ENSG00000137274 'BPHL intron_variant ENSG00000137274 ENSG00000137274 'BPHL 3 novel suggestive_specific_pathway BPHL chr6 3118374 3153578 1 670 protein_coding 6:3150869 32495 204_3_1 SeqId_12859_33 'PECI chr6:4113123_A_G$SeqId_12859_33 1 chr6:4113123_A_G rs853417 cis 6 4113123 A G 0.3228 -0.7089 0.0119 3.35e-773 'Enoyl-CoA delta isomerase 2, mitochondrial ENSG00000198721 'ECI2 intron_variant 0.755635 rs3177253 ENSG00000198721 'ECI2 missense_variant ENSG00000198721 ENSG00000198721 'ECI2 3 known specific_protein ECI2 chr6 4115693 4135597 -1 10455 protein_coding 6:4112889 22708 205_2_1 SeqId_11212_7 'TXND5 chr6:7887339_D_I$SeqId_11212_7 1 chr6:7887339_D_I rs142437697 cis 6 7887339 D I 0.8581 0.2614 0.0184 1.23e-45 'Thioredoxin domain-containing protein 5 ENSG00000239264 'TXNDC5 intron_variant 0.259839 rs183777097 ENSG00000239264 'TXNDC5 missense_variant ENSG00000239264 ENSG00000239264 'TXNDC5 3 novel specific_protein TXNDC5 chr6 7881517 7910788 -1 81567 protein_coding 6:7887107 23681 207_1_1 SeqId_19254_125 'GMPR1 chr6:16288615_A_G$SeqId_19254_125 1 chr6:16288615_A_G rs2327958 cis 6 16288615 A G 0.6043 -1.1986 0.0076 4.85e-5404 'GMP reductase 1 ENSG00000137198 'GMPR intron_variant 0.998569 rs1042391 ENSG00000137198 'GMPR missense_variant ENSG00000137198 ENSG00000137198 'GMPR 7 novel specific_pathway GMPR chr6 16238587 16295549 1 2766 protein_coding 6:16288384 49797 208_1_1 SeqId_5631_83 'MOTI chr6:20683164_A_G$SeqId_5631_83 1 chr6:20683164_A_G rs9350271 trans 6 20683164 A G 0.3115 0.1063 0.0135 3.23e-15 'Promotilin ENSG00000096395 'MLN intron_variant ENSG00000145996 ENSG00000145996 'CDKAL1 1 novel specific_protein MLN chr6 33794673 33804003 -1 4295 protein_coding 6:20682933 13121070 209_1_5 SeqId_17675_17 'ACO13 chr6:24714433_A_G$SeqId_17675_17 1 chr6:24714433_A_G rs11753290 cis 6 24714433 A G 0.2165 0.1292 0.0155 6.58e-17 'Acyl-coenzyme A thioesterase 13 ENSG00000112304 'ACOT13 intron_variant ENSG00000112304 ENSG00000112304 'ACOT13 3 novel specific_protein ACOT13 chr6 24667035 24705065 1 55856 protein_coding 6:24714205 47170 209_10_1 SeqId_16900_29 'MDGA1 chr6:37663624_C_T$SeqId_16900_29 1 chr6:37663624_C_T rs9349050 cis 6 37663624 T C 0.4902 1.0703 0.0085 7.54e-3446 'MAM domain-containing glycosylphosphatidylinositol anchor protein 1 ENSG00000112139 'MDGA1 intron_variant ENSG00000112139 ENSG00000112139 'MDGA1 3 novel specific_protein 1.0861 0.039194 1.20226443461741e-101 yes MDGA1 Olink NEUROLOGY(v.8011) MDGA1 chr6 37630679 37699306 -1 266727 protein_coding 6:37695848 3458 209_10_2 SeqId_9883_29 'Glyoxalase I chr6:38588203_C_T$SeqId_9883_29 1 chr6:38588203_C_T rs35152718 cis 6 38588203 T C 0.1062 -0.1908 0.0213 3.78e-19 'Lactoylglutathione lyase ENSG00000124767 'GLO1 intron_variant ENSG00000124767 ENSG00000124767 'GLO1 3 known specific_protein GLO1 chr6 38675925 38703145 -1 2739 protein_coding 6:38620427 82718 209_2_2 SeqId_17692_2 'BT3A3 chr6:26370659_C_T$SeqId_17692_2 1 chr6:26370659_C_T rs9393711 cis 6 26370659 T C 0.1259 -1.3423 0.0158 5.24e-1570 'Butyrophilin subfamily 3 member A3 ENSG00000111801 'BTN3A3 synonymous_variant ENSG00000111801 ENSG00000111801 'BTN3A3 3 known unspecific_effect BTN3A3 chr6 26440472 26453415 1 10384 protein_coding 6:26370431 70041 209_5_21 SeqId_2730_58 'MICA chr6:31377719_C_T$SeqId_2730_58 1 chr6:31377719_C_T 6:31377719_T_C none 6 31377719 T C 0.5346 0.9191 0.0103 8.13e-1732 'MHC class I polypeptide-related sequence A intron_variant 0.154437 6:31380160_I_D ENSG00000204520 'MICA frameshift_variant none none ' known unspecific_effect MICA chr6 31399784 31415315 1 100507436 protein_coding 6:31409942 10158 209_5_24 SeqId_5102_55 'MICB chr6:31473957_C_G$SeqId_5102_55 1 chr6:31473957_C_G rs3134900 cis 6 31473957 C G 0.8673 0.9911 0.0173 2.88e-715 'MHC class I polypeptide-related sequence B ENSG00000204516 'MICB missense_variant ENSG00000204516 ENSG00000204516 'MICB 3 known unspecific_effect MICB chr6 31494881 31511124 1 4277 protein_coding 6:31506180 11299 209_5_25 SeqId_3003_29 'NKp30 chr6:31556709_A_G$SeqId_3003_29 1 chr6:31556709_A_G rs986475 cis 6 31556709 A G 0.9134 0.4539 0.0237 7.79e-82 'Natural cytotoxicity triggering receptor 3 ENSG00000204475 'NCR3 3_prime_UTR_variant ENSG00000204475 ENSG00000204475 'NCR3 3 known unspecific_effect NCR3 chr6 31588895 31593006 -1 259197 protein_coding 6:31588932 4074 209_6_11 SeqId_13374_4 'DB113 chr6:31914179_C_T$SeqId_13374_4 1 chr6:31914179_C_T rs12614 trans 6 31914179 T C 0.0931 0.2692 0.023 1.5e-31 'Beta-defensin 113 ENSG00000214642 'DEFB113 missense_variant ENSG00000243649 ENSG00000243649 'CFB 3 known unspecific_effect DEFB113 chr6 49968677 49969625 -1 245927 protein_coding 6:31946402 18023223 209_6_12 SeqId_16057_6 'IGF-II receptor chr6:32604221_A_G$SeqId_16057_6 1 chr6:32604221_A_G 6:32604221_A_G trans 6 32604221 A G 0.8684 -0.1698 0.0208 3.17e-16 'Cation-independent mannose-6-phosphate receptor ENSG00000197081 'IGF2R upstream_gene_variant 0.494776 6:32599717_A_G ENSG00000196735 'HLA-DQA1 splice_acceptor_variant ENSG00000168394|ENSG00000196126|ENSG00000198502|ENSG00000204264|ENSG00000204287|ENSG00000206297|ENSG00000206298|ENSG00000206301|ENSG00000206308|ENSG00000223793|ENSG00000224212|ENSG00000225103|ENSG00000226173|ENSG00000226201|ENSG00000226260|ENSG00000227816|ENSG00000227993|ENSG00000228987|ENSG00000230034|ENSG00000230669|ENSG00000230705|ENSG00000230726|ENSG00000231526|ENSG00000231631|ENSG00000231823|ENSG00000232367|ENSG00000233192|ENSG00000234794|ENSG00000235715|ENSG00000236443|ENSG00000237541|ENSG00000239836|ENSG00000240065|ENSG00000240118|ENSG00000240508|ENSG00000242711|ENSG00000243067|ENSG00000243594|ENSG00000243958|ENSG00000257473 ENSG00000168394|ENSG00000179344|ENSG00000196126|ENSG00000198502|ENSG00000204264|ENSG00000204287|ENSG00000204296|ENSG00000204305|ENSG00000204344|ENSG00000204371|ENSG00000206297|ENSG00000206298|ENSG00000206301|ENSG00000206308|ENSG00000206320|ENSG00000223793|ENSG00000224212|ENSG00000225103|ENSG00000226173|ENSG00000226201|ENSG00000226260|ENSG00000227816|ENSG00000227993|ENSG00000228987|ENSG00000229058|ENSG00000230034|ENSG00000230514|ENSG00000230669|ENSG00000230705|ENSG00000230726|ENSG00000231268|ENSG00000231526|ENSG00000231631|ENSG00000231823|ENSG00000231852|ENSG00000232367|ENSG00000233192|ENSG00000234729|ENSG00000234794|ENSG00000235040|ENSG00000235715|ENSG00000236443|ENSG00000237405|ENSG00000237541|ENSG00000239836|ENSG00000240065|ENSG00000240118|ENSG00000240508|ENSG00000242711|ENSG00000243067|ENSG00000243594|ENSG00000243958|ENSG00000257473 'AGER|AGER|AGER|AGER|AGER|AGER|AGER|CYP21A2|EHMT2|HLA-DQA1|HLA-DQA2|HLA-DQA2|HLA-DQA2|HLA-DQA2|HLA-DQA2|HLA-DQA2|HLA-DQA2|HLA-DQB1|HLA-DRA|HLA-DRA|HLA-DRA|HLA-DRA|HLA-DRA|HLA-DRA|HLA-DRA|HLA-DRB1|HLA-DRB5|PSMB8|PSMB8|PSMB8|PSMB8|PSMB8|PSMB8|PSMB8|PSMB8|PSMB9|PSMB9|PSMB9|PSMB9|PSMB9|PSMB9|PSMB9|PSMB9|STK19|TAP1|TAP1|TAP1|TAP1|TAP1|TAP1|TAP1|TSBP1 1 known unspecific_effect IGF2R chr6 159969082 160113507 1 3482 protein_coding 6:32636444 127332638 209_6_16 SeqId_16913_8 'RNT2 chr6:32597064_A_G$SeqId_16913_8 1 chr6:32597064_A_G rs74927567 trans 6 32597064 A G 0.5981 -0.149 0.0136 4.33e-28 'Ribonuclease T2 ENSG00000026297 'RNASET2 intron_variant 0.409647 6:32599717_A_G ENSG00000196735 'HLA-DQA1 splice_acceptor_variant ENSG00000196126|ENSG00000198502|ENSG00000204252|ENSG00000204264|ENSG00000204287|ENSG00000206292|ENSG00000206298|ENSG00000206301|ENSG00000206308|ENSG00000223793|ENSG00000225103|ENSG00000226201|ENSG00000226260|ENSG00000226264|ENSG00000227993|ENSG00000228987|ENSG00000230034|ENSG00000230141|ENSG00000230669|ENSG00000230726|ENSG00000231526|ENSG00000231558|ENSG00000231631|ENSG00000231823|ENSG00000232957|ENSG00000232962|ENSG00000233192|ENSG00000234154|ENSG00000234794|ENSG00000235715|ENSG00000235744|ENSG00000236443|ENSG00000237541|ENSG00000239329|ENSG00000239457|ENSG00000239836|ENSG00000240065|ENSG00000240118|ENSG00000240508|ENSG00000241106|ENSG00000241296|ENSG00000241386|ENSG00000241674|ENSG00000241910|ENSG00000242092|ENSG00000242386|ENSG00000242574|ENSG00000242711|ENSG00000243067|ENSG00000243496|ENSG00000243594|ENSG00000243612|ENSG00000243958|ENSG00000257473 ENSG00000196126|ENSG00000198502|ENSG00000204252|ENSG00000204264|ENSG00000204287|ENSG00000206292|ENSG00000206298|ENSG00000206301|ENSG00000206308|ENSG00000223793|ENSG00000225103|ENSG00000226201|ENSG00000226260|ENSG00000226264|ENSG00000227993|ENSG00000228987|ENSG00000230034|ENSG00000230141|ENSG00000230669|ENSG00000230726|ENSG00000231526|ENSG00000231558|ENSG00000231631|ENSG00000231823|ENSG00000232957|ENSG00000232962|ENSG00000233192|ENSG00000234154|ENSG00000234794|ENSG00000235715|ENSG00000235744|ENSG00000236443|ENSG00000237541|ENSG00000239329|ENSG00000239457|ENSG00000239836|ENSG00000240065|ENSG00000240118|ENSG00000240508|ENSG00000241106|ENSG00000241296|ENSG00000241386|ENSG00000241674|ENSG00000241910|ENSG00000242092|ENSG00000242386|ENSG00000242574|ENSG00000242711|ENSG00000243067|ENSG00000243496|ENSG00000243594|ENSG00000243612|ENSG00000243958|ENSG00000257473 'HLA-DMB|HLA-DMB|HLA-DMB|HLA-DMB|HLA-DMB|HLA-DMB|HLA-DMB|HLA-DMB|HLA-DOA|HLA-DOA|HLA-DOA|HLA-DOA|HLA-DOA|HLA-DOA|HLA-DOA|HLA-DOB|HLA-DOB|HLA-DOB|HLA-DOB|HLA-DOB|HLA-DOB|HLA-DQA1|HLA-DQA2|HLA-DQA2|HLA-DQA2|HLA-DQA2|HLA-DQA2|HLA-DQA2|HLA-DQA2|HLA-DRA|HLA-DRA|HLA-DRA|HLA-DRA|HLA-DRA|HLA-DRA|HLA-DRA|HLA-DRB1|HLA-DRB5|PSMB8|PSMB8|PSMB8|PSMB8|PSMB8|PSMB8|PSMB8|PSMB8|PSMB9|PSMB9|PSMB9|PSMB9|PSMB9|PSMB9|PSMB9|PSMB9 1 known unspecific_effect RNASET2 chr6 166922113 166957191 -1 8635 protein_coding 6:32629287 134327904 209_6_2 SeqId_10012_5 'SPDEF chr6:31974849_C_G$SeqId_10012_5 1 chr6:31974849_C_G rs9501393 trans 6 31974849 C G 0.8524 -0.2486 0.0197 1.5e-36 'SAM pointed domain-containing Ets transcription factor ENSG00000124664 'SPDEF downstream_gene_variant 0.949493 rs449643 ENSG00000204351 'SKIV2L missense_variant ENSG00000204351 ENSG00000243649|ENSG00000244731 'C4A|CFB 6 known unspecific_effect SPDEF chr6 34537802 34556333 -1 25803 protein_coding 6:32007072 2549261 209_6_2 SeqId_11380_84 'RBM24 chr6:31934372_C_T$SeqId_11380_84 1 chr6:31934372_C_T rs454212 trans 6 31934372 T C 0.1366 0.2061 0.0196 7.43e-26 'RNA-binding protein 24 ENSG00000112183 'RBM24 intron_variant 0.986804 rs449643 ENSG00000204351 'SKIV2L missense_variant ENSG00000204351 ENSG00000243649|ENSG00000244731 'C4A|CFB 6 known unspecific_effect RBM24 chr6 17281361 17293871 1 221662 protein_coding 6:31966595 14685234 209_6_2 SeqId_12041_33 'HS71L chr6:31904729_D_I$SeqId_12041_33 1 chr6:31904729_D_I 6:31904729_I_D cis 6 31904729 D I 0.0969 0.2405 0.0227 3.33e-26 'Heat shock 70 kDa protein 1-like ENSG00000204390 'HSPA1L intron_variant 0.983961 rs641153 ENSG00000243649 'CFB missense_variant ENSG00000204390 ENSG00000243649|ENSG00000244731 'C4A|CFB 6 known unspecific_effect HSPA1L chr6 31809619 31815283 -1 3305 protein_coding 6:31936952 121669 209_6_2 SeqId_12939_1 'RPAC1 chr6:31935311_C_T$SeqId_12939_1 1 chr6:31935311_C_T rs453821 trans 6 31935311 T C 0.1363 0.2471 0.0194 4.49e-37 'DNA-directed RNA polymerases I and III subunit RPAC1 ENSG00000171453 'POLR1C intron_variant 0.985828 rs449643 ENSG00000204351 'SKIV2L missense_variant ENSG00000204351 ENSG00000243649|ENSG00000244731 'C4A|CFB 6 known unspecific_effect POLR1C chr6 43509702 43562419 1 9533 protein_coding 6:31967534 11542168 209_6_2 SeqId_12991_49 'CUL9 chr6:31905130_A_G$SeqId_12991_49 1 chr6:31905130_A_G rs1042663 trans 6 31905130 A G 0.0963 0.1973 0.0241 2.39e-16 'Cullin-9 ENSG00000112659 'CUL9 synonymous_variant 0.987217 rs641153 ENSG00000243649 'CFB missense_variant ENSG00000243649 ENSG00000243649|ENSG00000244731 'C4A|CFB 6 known unspecific_effect CUL9 chr6 43182184 43224587 1 23113 protein_coding 6:31937353 11244831 209_6_2 SeqId_13011_20 'RS10 chr6:31944320_A_G$SeqId_13011_20 1 chr6:31944320_A_G 6:31944320_A_G trans 6 31944320 A G 0.8615 -0.193 0.0196 6.66e-23 '40S ribosomal protein S10 ENSG00000124614 'RPS10 intron_variant 0.979713 rs449643 ENSG00000204351 'SKIV2L missense_variant ENSG00000204351 ENSG00000243649|ENSG00000244731 'C4A|CFB 6 known unspecific_effect RPS10 chr6 34417454 34426069 -1 6204 protein_coding 6:31976543 2449526 209_6_2 SeqId_13083_18 'SYVC chr6:31935311_C_T$SeqId_13083_18 1 chr6:31935311_C_T rs453821 cis 6 31935311 T C 0.1363 0.1897 0.0196 3.12e-22 'Valine--tRNA ligase ENSG00000204394 'VARS intron_variant 0.985828 rs449643 ENSG00000204351 'SKIV2L missense_variant ENSG00000204394 ENSG00000243649|ENSG00000244731 'C4A|CFB 6 known unspecific_effect VARS1 chr6 31777518 31795752 -1 7407 protein_coding 6:31967534 171782 209_6_2 SeqId_14197_2 'PRDM1 chr6:31934372_C_T$SeqId_14197_2 1 chr6:31934372_C_T rs454212 trans 6 31934372 T C 0.1366 0.1899 0.0196 4.13e-22 'PR domain zinc finger protein 1 ENSG00000057657 'PRDM1 intron_variant 0.986804 rs449643 ENSG00000204351 'SKIV2L missense_variant ENSG00000204351 ENSG00000243649|ENSG00000244731 'C4A|CFB 6 known unspecific_effect PRDM1 chr6 105993463 106109939 1 639 protein_coding 6:31966595 74026868 209_6_2 SeqId_14645_253 'GSTA4 chr6:31947594_C_G$SeqId_14645_253 1 chr6:31947594_C_G rs389512 trans 6 31947594 C G 0.1373 0.2462 0.0193 3.36e-37 'Glutathione S-transferase A4 ENSG00000170899 'GSTA4 intron_variant 0.975609 rs449643 ENSG00000204351 'SKIV2L missense_variant ENSG00000204351 ENSG00000243649|ENSG00000244731 'C4A|CFB 6 known unspecific_effect GSTA4 chr6 52977948 52995304 -1 2941 protein_coding 6:31979817 21015487 209_6_2 SeqId_5008_51 'Mn SOD chr6:31976899_C_T$SeqId_5008_51 1 chr6:31976899_C_T 6:31976899_C_T trans 6 31976899 T C 0.2078 0.2428 0.0176 1.75e-43 'Superoxide dismutase [Mn], mitochondrial ENSG00000112096 'SOD2 upstream_gene_variant 0.107981 rs61338903 ENSG00000231852 'CYP21A2 inframe_insertion ENSG00000268923|ENSG00000206340|ENSG00000227746|ENSG00000244731 ENSG00000243649|ENSG00000244731 'C4A|CFB 6 known unspecific_effect SOD2 chr6 159669069 159762529 -1 6648 protein_coding 6:32009122 127753407 209_6_2 SeqId_17772_7 'UBD chr6:31934372_C_T$SeqId_17772_7 1 chr6:31934372_C_T rs454212 trans 6 31934372 T C 0.1366 0.2113 0.0197 8.07e-27 'Ubiquitin D ENSG00000213886 'UBD intron_variant 0.986804 rs449643 ENSG00000204351 'SKIV2L missense_variant ENSG00000204351 ENSG00000243649|ENSG00000244731 'C4A|CFB 6 known unspecific_effect UBD chr6 29555515 29559732 -1 10537 protein_coding 6:31966595 2406863 209_6_2 SeqId_18399_1 'AKA7A chr6:31916951_C_T$SeqId_18399_1 1 chr6:31916951_C_T rs541862 trans 6 31916951 T C 0.9026 -0.2464 0.0228 3.22e-27 'A-kinase anchor protein 7 isoforms alpha and beta ENSG00000118507 'AKAP7 intron_variant 0.990463 rs641153 ENSG00000243649 'CFB missense_variant ENSG00000243649 ENSG00000243649|ENSG00000244731 'C4A|CFB 6 known unspecific_effect AKAP7 chr6 131135467 131283535 1 9465 protein_coding 6:31949174 99186293 209_6_2 SeqId_18927_14 'RET1G chr6:31934372_C_T$SeqId_18927_14 1 chr6:31934372_C_T rs454212 trans 6 31934372 T C 0.1366 0.1999 0.0194 7.61e-25 'Retinoic acid early transcript 1G protein ENSG00000203722 'RAET1G intron_variant 0.986804 rs449643 ENSG00000204351 'SKIV2L missense_variant ENSG00000204351 ENSG00000243649|ENSG00000244731 'C4A|CFB 6 known unspecific_effect RAET1G chr6 149916878 149923121 -1 353091 protein_coding 6:31966595 117956526 209_6_2 SeqId_3082_9 'ULBP-2 chr6:31976899_C_T$SeqId_3082_9 1 chr6:31976899_C_T 6:31976899_C_T trans 6 31976899 T C 0.2077 -0.1261 0.0178 1.61e-12 'NKG2D ligand 2 ENSG00000131015 'ULBP2 upstream_gene_variant 0.107981 rs61338903 ENSG00000231852 'CYP21A2 inframe_insertion ENSG00000268923|ENSG00000206340|ENSG00000227746|ENSG00000244731 ENSG00000243649|ENSG00000244731 'C4A|CFB 6 known unspecific_effect ULBP2 chr6 149942014 149949235 1 80328 protein_coding 6:32009122 117932892 209_6_2 SeqId_4129_72 'Factor B chr6:31914180_A_G$SeqId_4129_72 1 chr6:31914180_A_G rs641153 cis 6 31914180 A G 0.0968 0.7268 0.0216 5.51e-248 'Complement factor B ENSG00000243649 'CFB missense_variant ENSG00000243649 ENSG00000243649|ENSG00000244731 'C4A|CFB 6 known unspecific_effect CFB chr6 31945650 31952084 1 629 protein_coding 6:31946403 753 209_6_2 SeqId_4150_75 'Plasmin chr6:31920687_C_T$SeqId_4150_75 1 chr6:31920687_C_T rs550513 trans 6 31920687 T C 0.0973 0.1927 0.0227 2.43e-17 'Plasmin ENSG00000122194 'PLG intron_variant 0.997454 rs438999 ENSG00000204351 'SKIV2L missense_variant ENSG00000204351 ENSG00000243649|ENSG00000244731 'C4A|CFB 6 known unspecific_effect PLG chr6 160702238 160754097 1 5340 protein_coding 6:31952910 128749328 209_6_2 SeqId_4224_7 'HNRPQ chr6:31947594_C_G$SeqId_4224_7 1 chr6:31947594_C_G rs389512 trans 6 31947594 C G 0.1373 0.2363 0.0196 1.86e-33 'Heterogeneous nuclear ribonucleoprotein Q ENSG00000135316 'SYNCRIP intron_variant 0.975609 rs449643 ENSG00000204351 'SKIV2L missense_variant ENSG00000204351 ENSG00000243649|ENSG00000244731 'C4A|CFB 6 known unspecific_effect SYNCRIP chr6 85607779 85644063 -1 10492 protein_coding 6:31979817 53664246 209_6_2 SeqId_9032_30 'ROS1 chr6:31910929_A_G$SeqId_9032_30 1 chr6:31910929_A_G rs2242572 trans 6 31910929 A G 0.097 0.1593 0.0228 2.79e-12 'Proto-oncogene tyrosine-protein kinase ROS ENSG00000047936 'ROS1 intron_variant 0.996157 rs641153 ENSG00000243649 'CFB missense_variant ENSG00000243649 ENSG00000243649|ENSG00000244731 'C4A|CFB 6 known unspecific_effect ROS1 chr6 117287353 117425942 -1 6098 protein_coding 6:31943152 85482790 209_6_2 SeqId_5085_18 'IL-20 Ra chr6:31974849_C_G$SeqId_5085_18 1 chr6:31974849_C_G rs9501393 trans 6 31974849 C G 0.8524 0.1484 0.0198 7.45e-14 'Interleukin-20 receptor subunit alpha ENSG00000016402 'IL20RA downstream_gene_variant 0.949493 rs449643 ENSG00000204351 'SKIV2L missense_variant ENSG00000204351 ENSG00000243649|ENSG00000244731 'C4A|CFB 6 known unspecific_effect IL20RA chr6 136999971 137045180 -1 53832 protein_coding 6:32007072 105038108 209_6_2 SeqId_8334_65 'TCP11 chr6:31976899_C_T$SeqId_8334_65 1 chr6:31976899_C_T 6:31976899_C_T trans 6 31976899 T C 0.2077 0.1434 0.0171 5.51e-17 'T-complex protein 11 homolog ENSG00000124678 'TCP11 upstream_gene_variant 0.107981 rs61338903 ENSG00000231852 'CYP21A2 inframe_insertion ENSG00000268923 ENSG00000243649|ENSG00000244731 'C4A|CFB 6 known unspecific_effect TCP11 chr6 35118071 35148610 -1 6954 protein_coding 6:32009122 3139488 209_6_2 SeqId_9786_310 'IEX1 chr6:31935311_C_T$SeqId_9786_310 1 chr6:31935311_C_T rs453821 trans 6 31935311 T C 0.1363 0.187 0.0197 2.02e-21 'Radiation-inducible immediate-early gene IEX-1 ENSG00000137331 'IER3 intron_variant 0.985828 rs449643 ENSG00000204351 'SKIV2L missense_variant ENSG00000204351 ENSG00000243649|ENSG00000244731 'C4A|CFB 6 known unspecific_effect IER3 chr6 30743199 30744548 -1 8870 protein_coding 6:31967534 1222986 209_6_2 SeqId_8985_13 'SRAC1 chr6:31976899_C_T$SeqId_8985_13 1 chr6:31976899_C_T 6:31976899_C_T trans 6 31976899 T C 0.2077 0.1358 0.0177 1.75e-14 'Protein SERAC1 ENSG00000122335 'SERAC1 upstream_gene_variant 0.107981 rs61338903 ENSG00000231852 'CYP21A2 inframe_insertion ENSG00000268923 ENSG00000243649|ENSG00000244731 'C4A|CFB 6 known unspecific_effect SERAC1 chr6 158109519 158168280 -1 84947 protein_coding 6:32009122 126159158 209_6_20 SeqId_11387_3 'ATF6B chr6:32083175_C_T$SeqId_11387_3 1 chr6:32083175_C_T rs8111 cis 6 32083175 T C 0.2728 0.2635 0.0137 6.63e-82 'Cyclic AMP-dependent transcription factor ATF-6 beta ENSG00000213676 'ATF6B 3_prime_UTR_variant 0.741535 rs61338903 ENSG00000231852 'CYP21A2 inframe_insertion ENSG00000213676 ENSG00000213676 'ATF6B 7 known unspecific_effect ATF6B chr6 32115264 32128253 -1 1388 protein_coding 6:32115398 12855 209_6_21 SeqId_9969_8 'S22AG chr6:32561527_C_T$SeqId_9969_8 1 chr6:32561527_C_T 6:32561527_T_C trans 6 32561527 T C 0.8184 0.2236 0.0178 5.29e-36 'Solute carrier family 22 member 16 ENSG00000004809 'SLC22A16 upstream_gene_variant 0.316938 rs201699945 ENSG00000198502 'HLA-DRB5 splice_acceptor_variant ENSG00000196126 ENSG00000196126|ENSG00000204287|ENSG00000204301|ENSG00000206301|ENSG00000206308|ENSG00000223355|ENSG00000223793|ENSG00000225103|ENSG00000226260|ENSG00000227993|ENSG00000228987|ENSG00000230726|ENSG00000231526|ENSG00000231823|ENSG00000233192|ENSG00000234794|ENSG00000234876|ENSG00000237541|ENSG00000238196|ENSG00000257473 'HLA-DQA1|HLA-DQA2|HLA-DQA2|HLA-DQA2|HLA-DQA2|HLA-DQA2|HLA-DQA2|HLA-DQA2|HLA-DRA|HLA-DRA|HLA-DRA|HLA-DRA|HLA-DRA|HLA-DRA|HLA-DRA|HLA-DRB1|NOTCH4|NOTCH4|NOTCH4|NOTCH4 2 known unspecific_effect SLC22A16 chr6 110424687 110476641 -1 85413 protein_coding 6:32593750 77882891 209_6_22 SeqId_4124_24 'HSP 70 chr6:31783863_C_G$SeqId_4124_24 1 chr6:31783863_C_G 6:31783863_G_C cis 6 31783863 C G 0.1049 0.2943 0.0208 1.42e-45 'Heat shock 70 kDa protein 1A ENSG00000204389 'HSPA1A missense_variant ENSG00000204389 ENSG00000204389 'HSPA1A 6 known unspecific_effect HSPA1A chr6 31815543 31817946 1 3303 protein_coding 6:31816086 543 209_6_24 SeqId_2849_49 'AIF1 chr6:31603591_A_G$SeqId_2849_49 1 chr6:31603591_A_G rs2261033 cis 6 31603591 A G 0.547 0.2788 0.0127 2.35e-107 'Allograft inflammatory factor 1 ENSG00000204472 'AIF1 intron_variant ENSG00000204472 ENSG00000204472 'AIF1 3 known unspecific_effect AIF1 chr6 31615217 31617021 1 199 protein_coding 6:31635814 20597 209_6_25 SeqId_10445_20 'ApoM chr6:31605167_A_G$SeqId_10445_20 1 chr6:31605167_A_G rs2255741 cis 6 31605167 A G 0.0299 -0.7911 0.039 2.83e-91 'Apolipoprotein M ENSG00000204444 'APOM intron_variant ENSG00000204444 ENSG00000204444 'APOM 3 known unspecific_effect -0.76956 0.17512 1.36489737964495e-05 yes APOM Olink CARDIOMETABOLIC(v.3602) APOM chr6 31652416 31658210 1 55937 protein_coding 6:31637390 15026 209_6_27 SeqId_3186_2 'C2 chr6:31704411_A_G$SeqId_3186_2 1 chr6:31704411_A_G rs115204832 cis 6 31704411 A G 0.9889 1.5437 0.0646 4.43e-126 'Complement C2 ENSG00000166278 'C2 intron_variant 0.592147 rs9332736 ENSG00000166278 'C2 frameshift_variant ENSG00000166278 ENSG00000166278 'C2 3 known unspecific_effect 2.0329 0.31342 2.17720839387283e-10 yes C2 Olink CARDIOMETABOLIC(v.3602) C2 chr6 31897785 31945672 1 717 protein_coding 6:31736634 161151 209_6_30 SeqId_5698_60 'Tenascin-X chr6:31935392_C_T$SeqId_5698_60 1 chr6:31935392_C_T rs45451301 cis 6 31935392 T C 0.9745 1.7878 0.0388 1.62e-463 'Tenascin-X ENSG00000168477 'TNXB intron_variant ENSG00000168477 ENSG00000168477 'TNXB 3 known unspecific_effect 0.52928 0.20509 0.0101531312414576 yes TNXB Olink CARDIOMETABOLIC(v.3602) TNXB chr6 32041153 32115334 -1 7148 protein_coding 6:31967615 147719 209_6_35 SeqId_4125_52 'sRAGE chr6:32151443_C_T$SeqId_4125_52 1 chr6:32151443_C_T rs2070600 cis 6 32151443 T C 0.0552 -0.6511 0.0287 1.24e-113 'Advanced glycosylation end product-specific receptor, soluble ENSG00000204305 'AGER missense_variant ENSG00000204305 ENSG00000204305 'AGER 3 known unspecific_effect -0.02868 0.13094 0.826711540091597 no RAGE Olink CARDIOVASCULAR II(v.5004) AGER chr6 32180968 32184322 -1 177 protein_coding 6:32183666 656 209_6_48 SeqId_7757_5 'DQA2 chr6:32590159_A_C$SeqId_7757_5 1 chr6:32590159_A_C 6:32590159_C_A cis 6 32590159 A C 0.5321 0.4109 0.0132 2.14e-213 'HLA class II histocompatibility antigen, DQ alpha 2 chain ENSG00000237541 'HLA-DQA2 regulatory_region_variant ENSG00000237541 ENSG00000237541 'HLA-DQA2 3 known unspecific_effect HLA-DQA2 chr6 32741391 32747198 1 3118 protein_coding 6:32622382 119009 209_7_6 SeqId_11278_4 'COL11A2 chr6:33125859_G_T$SeqId_11278_4 1 chr6:33125859_G_T rs3129205 cis 6 33125859 T G 0.3413 0.229 0.0137 1.67e-62 'Collagen alpha-2(XI) chain ENSG00000204248 'COL11A2 downstream_gene_variant ENSG00000204248 ENSG00000204248 'COL11A2 3 known suggestive_specific_pathway COL11A2 chr6 33162681 33192499 -1 1302 protein_coding 6:33158082 34417 209_8_1 SeqId_12378_71 'TPSN chr6:33275013_C_T$SeqId_12378_71 1 chr6:33275013_C_T rs3135408 cis 6 33275013 T C 0.4669 0.47 0.0122 4.20e-322 'Tapasin ENSG00000231925 'TAPBP intron_variant 0.999776 rs2071888 ENSG00000231925 'TAPBP missense_variant ENSG00000231925 ENSG00000231925 'TAPBP 3 novel suggestive_specific_pathway TAPBP chr6 33299694 33314254 -1 6892 protein_coding 6:33307236 7018 209_8_2 SeqId_5631_83 'MOTI chr6:33778619_A_G$SeqId_5631_83 1 chr6:33778619_A_G rs9357165 cis 6 33778619 A G 0.4621 0.4198 0.012 3.02e-266 'Promotilin ENSG00000096395 'MLN intergenic_variant ENSG00000096395 ENSG00000096395 'MLN 3 known specific_protein MLN chr6 33794673 33804003 -1 4295 protein_coding 6:33810842 6839 209_8_3 SeqId_16773_29 'SCUB3 chr6:35121346_A_T$SeqId_16773_29 1 chr6:35121346_A_T rs6904920 cis 6 35121346 A T 0.2698 -0.2574 0.0147 2.91e-68 'Signal peptide, CUB and EGF-like domain-containing protein 3 ENSG00000146197 'SCUBE3 upstream_gene_variant ENSG00000146197 ENSG00000146197 'SCUBE3 3 novel specific_protein SCUBE3 chr6 35213956 35253079 1 222663 protein_coding 6:35153569 60387 209_8_4 SeqId_14090_23 'DEFI6 chr6:35265535_A_G$SeqId_14090_23 1 chr6:35265535_A_G rs45482297 cis 6 35265535 A G 0.0309 -0.6978 0.0356 1.65e-85 'Differentially expressed in FDCP 6 homolog ENSG00000023892 'DEF6 upstream_gene_variant ENSG00000023892 ENSG00000023892 'DEF6 3 known specific_protein DEF6 chr6 35297818 35321771 1 50619 protein_coding 6:35297758 60 209_9_2 SeqId_5749_53 'COL chr6:35753227_C_T$SeqId_5749_53 1 chr6:35753227_C_T rs2766588 cis 6 35753227 T C 0.3924 -0.4119 0.0132 7.44e-213 'Colipase ENSG00000137392 'CLPS intron_variant ENSG00000137392 ENSG00000137392 'CLPS 3 known unspecific_effect CLPS chr6 35794982 35797344 -1 1208 protein_coding 6:35785450 11894 209_9_3 SeqId_5006_71 'MK13 chr6:36098191_A_C$SeqId_5006_71 1 chr6:36098191_A_C rs12210904 cis 6 36098191 A C 0.2928 0.1878 0.0147 2.26e-37 'Mitogen-activated protein kinase 13 ENSG00000156711 'MAPK13 5_prime_UTR_variant ENSG00000156711 ENSG00000156711 'MAPK13 3 known specific_protein MAPK13 chr6 36127809 36144524 1 5603 protein_coding 6:36130414 2605 209_9_4 SeqId_9884_8 'PPIL1 chr6:36839598_C_G$SeqId_9884_8 1 chr6:36839598_C_G rs12194408 cis 6 36839598 C G 0.972 1.6602 0.0365 9.83e-452 'Peptidyl-prolyl cis-trans isomerase-like 1 ENSG00000137168 'PPIL1 missense_variant ENSG00000137168 ENSG00000137168 'PPIL1 3 known specific_protein PPIL1 chr6 36854827 36874803 -1 51645 protein_coding 6:36871822 2981 21_1_1 SeqId_17764_108 'RHOC chr1:113097849_D_I$SeqId_17764_108 1 chr1:113097849_D_I rs35935752 cis 1 113097849 D I 0.5259 -0.1429 0.013 5.62e-28 'Rho-related GTP-binding protein RhoC ENSG00000155366 'RHOC intron_variant ENSG00000155366 ENSG00000155366 'RHOC 3 novel specific_protein RHOC chr1 112701127 112707434 -1 389 protein_coding 1:112555228 152206 210_1_1 SeqId_16300_4 'TREM2 chr6:41129207_C_T$SeqId_16300_4 1 chr6:41129207_C_T rs143332484 cis 6 41129207 T C 0.0101 -1.2961 0.0622 2.13e-96 'Triggering receptor expressed on myeloid cells 2 ENSG00000095970 'TREM2 missense_variant ENSG00000095970 ENSG00000095970 'TREM2 3 novel specific_protein TREM2 chr6 41158506 41163186 -1 54209 protein_coding 6:41161469 1717 210_1_2 SeqId_5736_1 'TRML2 chr6:41167763_A_G$SeqId_5736_1 1 chr6:41167763_A_G rs62396356 cis 6 41167763 A G 0.8663 -1.0654 0.0166 4.26e-897 'Trem-like transcript 2 protein ENSG00000112195 'TREML2 intron_variant 0.994127 rs62396355 ENSG00000112195 'TREML2 missense_variant ENSG00000112195 ENSG00000112195 'TREML2 3 known suggestive_specific_pathway 0.13078 0.093857 0.164130767376121 no TLT-2 Olink CARDIOVASCULAR III(v.6112) TREML2 chr6 41189749 41201149 -1 79865 protein_coding 6:41200025 1124 210_1_3 SeqId_9266_1 'sTREM-1 chr6:41245837_D_I$SeqId_9266_1 1 chr6:41245837_D_I rs151289065 cis 6 41245837 D I 0.7133 -0.3569 0.0137 6.61e-150 'Triggering receptor expressed on myeloid cells 1 ENSG00000124731 'TREM1 intron_variant ENSG00000124731 ENSG00000124731 'TREM1 3 known specific_protein -0.52007 0.060141 7.78036551039801e-17 yes TREM1 Olink IMMUNE RESPONSE(v.3202) TREM1 chr6 41267926 41286682 -1 54210 protein_coding 6:41278100 8582 211_1_1 SeqId_17327_3 'CNPY3 chr6:42906242_C_T$SeqId_17327_3 1 chr6:42906242_C_T rs77807794 cis 6 42906242 T C 0.2558 -0.4083 0.0147 6.2e-169 'Protein canopy homolog 3 ENSG00000137161 'CNPY3 intron_variant 0.983145 rs9471969 ENSG00000137161 'CNPY3 missense_variant ENSG00000137161 ENSG00000137161 'CNPY3 6 known suggestive_specific_pathway CNPY3 chr6 42929480 42939294 1 10695 protein_coding 6:42938504 9024 211_1_2 SeqId_14006_36 'GNMT chr6:42922215_A_C$SeqId_14006_36 1 chr6:42922215_A_C rs6458314 cis 6 42922215 A C 0.5886 -0.4001 0.0133 5.49e-198 'Glycine N-methyltransferase ENSG00000124713 'GNMT downstream_gene_variant ENSG00000124713 ENSG00000124713 'GNMT 3 known suggestive_specific_pathway GNMT chr6 42960754 42963880 1 27232 protein_coding 6:42954477 6277 211_1_3 SeqId_9525_1 'PTK7 chr6:43067044_C_T$SeqId_9525_1 1 chr6:43067044_C_T rs140147428 cis 6 43067044 T C 0.0371 0.4105 0.0352 1.67e-31 'Inactive tyrosine-protein kinase 7 ENSG00000112655 'PTK7 intron_variant 0.44308 rs34764696 ENSG00000112655 'PTK7 missense_variant ENSG00000112655 ENSG00000112655 'PTK7 3 known specific_protein PTK7 chr6 43076307 43161719 1 5754 protein_coding 6:43099306 22999 211_1_4 SeqId_17785_11 'RCL chr6:43195827_D_I$SeqId_17785_11 1 chr6:43195827_D_I rs138632789 cis 6 43195827 D I 0.1149 -0.1803 0.0202 4.4e-19 '2'-deoxynucleoside 5'-phosphate N-hydrolase 1 ENSG00000112667 'DNPH1 intron_variant ENSG00000112667 ENSG00000112667 'DNPH1 3 novel suggestive_specific_pathway DNPH1 chr6 43225629 43229481 -1 10591 protein_coding 6:43228090 1391 211_1_5 SeqId_9359_9 'EGFL9 chr6:43408105_C_T$SeqId_9359_9 1 chr6:43408105_C_T rs67861980 cis 6 43408105 T C 0.256 -0.1768 0.0148 8.63e-33 'Protein delta homolog 2 ENSG00000171462 'DLK2 intron_variant ENSG00000171462 ENSG00000171462 'DLK2 3 known specific_protein DLK2 chr6 43450352 43456632 -1 65989 protein_coding 6:43440367 16265 211_2_1 SeqId_2597_8 'VEGF chr6:43925607_A_G$SeqId_2597_8 1 chr6:43925607_A_G rs6921438 cis 6 43925607 A G 0.4847 -0.4989 0.0123 1.11e-359 'Vascular endothelial growth factor A ENSG00000112715 'VEGFA intergenic_variant ENSG00000112715 ENSG00000112715 'VEGFA 3 known suggestive_specific_pathway -0.73206 0.054977 1.1641260294105e-34 yes VEGFA Olink INFLAMMATION(v.3012) VEGFA chr6 43770184 43786487 1 7422 protein_coding 6:43957870 187686 211_2_1 SeqId_19437_61 'L-VEGF165 chr6:43925607_A_G$SeqId_19437_61 1 chr6:43925607_A_G rs6921438 cis 6 43925607 A G 0.4847 -0.8073 0.0107 8.23e-1239 'Isoform L-VEGF165 ENSG00000112715 'VEGFA intergenic_variant ENSG00000112715 ENSG00000112715 'VEGFA 3 known suggestive_specific_pathway -0.73206 0.054977 1.1641260294105e-34 yes VEGFA Olink INFLAMMATION(v.3012) VEGFA chr6 43770184 43786487 1 7422 protein_coding 6:43957870 187686 211_2_1 SeqId_4867_15 'VEGF121 chr6:43925607_A_G$SeqId_4867_15 1 chr6:43925607_A_G rs6921438 cis 6 43925607 A G 0.4846 -0.8058 0.011 5.96e-1168 'Vascular endothelial growth factor A, isoform 121 ENSG00000112715 'VEGFA intergenic_variant ENSG00000112715 ENSG00000112715 'VEGFA 3 known suggestive_specific_pathway -0.73206 0.054977 1.1641260294105e-34 yes VEGFA Olink INFLAMMATION(v.3012) VEGFA chr6 43770184 43786487 1 7422 protein_coding 6:43957870 187686 212_1_1 SeqId_12475_48 'CLIC5 chr6:45916999_G_T$SeqId_12475_48 1 chr6:45916999_G_T rs35822882 cis 6 45916999 T G 0.0285 -1.0454 0.0356 1.41e-189 'Chloride intracellular channel protein 5 ENSG00000112782 'CLIC5 missense_variant ENSG00000112782 ENSG00000112782 'CLIC5 3 known specific_protein CLIC5 chr6 45880827 46080348 -1 53405 protein_coding 6:45949262 131086 212_1_3 SeqId_6556_5 'ENPP5 chr6:46130825_G_T$SeqId_6556_5 1 chr6:46130825_G_T rs77991465 cis 6 46130825 T G 0.0513 -1.6792 0.0235 2.11e-1111 'Ectonucleotide pyrophosphatase/phosphodiesterase family member 5 ENSG00000112796 'ENPP5 intron_variant 0.989806 rs34109856 ENSG00000112796 'ENPP5 missense_variant ENSG00000112796 ENSG00000112796 'ENPP5 3 known specific_protein ENPP5 chr6 46159185 46170980 -1 59084 protein_coding 6:46163088 7892 212_1_4 SeqId_5015_15 'PAFAH chr6:46689847_A_G$SeqId_5015_15 1 chr6:46689847_A_G rs9472831 cis 6 46689847 A G 0.4963 -0.1422 0.0135 4.46e-26 'Platelet-activating factor acetylhydrolase ENSG00000146070 'PLA2G7 intron_variant 0.331115 rs1805017 ENSG00000146070 'PLA2G7 missense_variant ENSG00000146070 ENSG00000146070 'PLA2G7 3 novel unspecific_effect PLA2G7 chr6 46704201 46735693 -1 7941 protein_coding 6:46722110 13583 212_1_5 SeqId_6409_57 'GP116 chr6:46831060_C_T$SeqId_6409_57 1 chr6:46831060_C_T rs476374 cis 6 46831060 T C 0.9377 1.4967 0.0241 3.97e-840 'Adhesion G protein-coupled receptor F5 ENSG00000069122 'GPR116 intron_variant 0.99811 rs586024 ENSG00000069122 'GPR116 missense_variant ENSG00000069122 ENSG00000069122 'ADGRF5 3 known specific_protein ADGRF5 chr6 46852522 46954943 -1 221395 protein_coding 6:46863323 91620 212_1_6 SeqId_5404_53 'DR6 chr6:47277569_A_G$SeqId_5404_53 1 chr6:47277569_A_G rs6458555 cis 6 47277569 A G 0.3064 0.1452 0.0146 2.53e-23 'Tumor necrosis factor receptor superfamily member 21 ENSG00000146072 'TNFRSF21 5_prime_UTR_variant ENSG00000146072 ENSG00000146072 'TNFRSF21 3 known specific_protein TNFRSF21 chr6 47231532 47309905 -1 27242 protein_coding 6:47309833 72 212_2_1 SeqId_9282_12 'CRIS2 chr6:49710105_A_G$SeqId_9282_12 1 chr6:49710105_A_G rs555247 cis 6 49710105 A G 0.4483 0.4988 0.011 5.56e-449 'Cysteine-rich secretory protein 2 ENSG00000124490 'CRISP2 intron_variant ENSG00000124490 ENSG00000124490 'CRISP2 3 known specific_protein 0.52154 0.048705 3.78442584717093e-24 yes CRISP2 Olink CELL REGULATION(v.3701) CRISP2 chr6 49692358 49713590 -1 7180 protein_coding 6:49742392 28802 212_3_1 SeqId_17138_8 'GST A1-1 chr6:52630269_A_C$SeqId_17138_8 1 chr6:52630269_A_C rs6458869 cis 6 52630269 A C 0.6421 0.4435 0.013 1.43e-253 'Glutathione S-transferase A1 ENSG00000243955 'GSTA1 upstream_gene_variant ENSG00000243955 ENSG00000243955 'GSTA1 3 known unspecific_effect GSTA1 chr6 52791371 52803860 -1 2938 protein_coding 6:52765471 38389 213_1_1 SeqId_6920_1 'GFRAL chr6:55258516_C_T$SeqId_6920_1 1 chr6:55258516_C_T rs60761034 cis 6 55258516 T C 0.1351 0.3516 0.0193 5.25e-74 'GDNF family receptor alpha-like ENSG00000187871 'GFRAL intron_variant ENSG00000187871 ENSG00000187871 'GFRAL 3 known specific_protein GFRAL chr6 55327469 55402493 1 389400 protein_coding 6:55393718 66249 214_1_1 SeqId_15466_30 'CO9A1 chr6:70987976_A_G$SeqId_15466_30 1 chr6:70987976_A_G rs3806095 cis 6 70987976 A G 0.3034 -0.185 0.0154 3.8e-33 'Collagen alpha-1(IX) chain ENSG00000112280 'COL9A1 intron_variant 0.686894 rs592121 ENSG00000112280 'COL9A1 missense_variant ENSG00000112280 ENSG00000112280 'COL9A1 3 novel specific_protein COL9A1 chr6 70216040 70303084 -1 1297 protein_coding 6:70278273 24811 214_1_2 SeqId_11649_3 'SMAP1 chr6:71349754_A_G$SeqId_11649_3 1 chr6:71349754_A_G rs1917342 cis 6 71349754 A G 0.7019 0.4868 0.0133 4.12e-293 'Stromal membrane-associated protein 1 ENSG00000112305 'SMAP1 regulatory_region_variant ENSG00000112305 ENSG00000112305 'SMAP1 3 novel specific_protein SMAP1 chr6 70667776 70862011 1 60682 protein_coding 6:70640051 27725 215_1_2 SeqId_3290_50 'CD109 chr6:74509578_C_G$SeqId_3290_50 1 chr6:74509578_C_G rs57799429 cis 6 74509578 C G 0.5105 0.7071 0.0115 1.43e-823 'CD109 antigen ENSG00000156535 'CD109 intron_variant 0.522061 rs2351528 ENSG00000156535 'CD109 missense_variant ENSG00000156535 ENSG00000156535 'CD109 3 known specific_protein 0.49524 0.056776 4.39541615437825e-17 yes CD109 Olink DEVELOPMENT(v.3511) CD109 chr6 73695785 73828316 1 135228 protein_coding 6:73799855 104070 215_2_1 SeqId_9894_13 'MYO6 chr6:76624538_A_G$SeqId_9894_13 1 chr6:76624538_A_G rs41269323 cis 6 76624538 A G 0.0107 -0.6171 0.0638 3.94e-22 'Unconventional myosin-VI ENSG00000196586 'MYO6 missense_variant ENSG00000196586 ENSG00000196586 'MYO6 3 novel specific_protein MYO6 chr6 75749201 75919537 1 4646 protein_coding 6:75914821 165620 216_1_1 SeqId_19113_66 'SH3L2 chr6:80326010_C_T$SeqId_19113_66 1 chr6:80326010_C_T rs2812679 cis 6 80326010 T C 0.5531 0.1087 0.0123 1.1e-18 'SH3 domain-binding glutamic acid-rich-like protein 2 ENSG00000198478 'SH3BGRL2 intergenic_variant ENSG00000198478 ENSG00000198478 'SH3BGRL2 3 novel specific_protein SH3BGRL2 chr6 79631329 79703655 1 83699 protein_coding 6:79616293 15036 217_1_1 SeqId_15452_5 '5'-Nucleotidase chr6:86103556_A_G$SeqId_15452_5 1 chr6:86103556_A_G rs643591 cis 6 86103556 A G 0.8865 0.4361 0.0195 2.45e-110 '5'-Nucleotidase ENSG00000135318 'NT5E upstream_gene_variant 0.372511 rs2229524 ENSG00000135318 'NT5E missense_variant ENSG00000135318 ENSG00000135318 'NT5E 3 novel specific_protein 0.62987 0.093586 4.81947797625127e-11 yes 5'-NT Olink ONCOLOGY II(v.7002) NT5E chr6 85449584 85495791 1 4907 protein_coding 6:85393838 55746 219_1_2 SeqId_8014_359 'MANEA chr6:96053922_A_T$SeqId_8014_359 1 chr6:96053922_A_T rs35772543 cis 6 96053922 A T 0.082 -1.6055 0.0188 2.09e-1586 'Glycoprotein endo-alpha-1,2-mannosidase ENSG00000172469 'MANEA missense_variant ENSG00000172469 ENSG00000172469 'MANEA 3 known specific_protein MANEA chr6 95577485 95609470 1 79694 protein_coding 6:95606046 28561 22_1_1 SeqId_8660_5 'OLFL3 chr1:114513488_G_T$SeqId_8660_5 1 chr1:114513488_G_T rs7522987 cis 1 114513488 T G 0.6836 0.158 0.0145 1.11e-27 'Olfactomedin-like protein 3 ENSG00000116774 'OLFML3 intron_variant ENSG00000116774 ENSG00000116774 'OLFML3 3 novel specific_protein OLFML3 chr1 113979391 114035572 1 56944 protein_coding 1:113970866 8525 220_1_1 SeqId_14273_19 'PPCE chr6:105775787_D_I$SeqId_14273_19 1 chr6:105775787_D_I rs71748560 cis 6 105775787 D I 0.8609 0.2211 0.0193 2.49e-30 'Prolyl endopeptidase ENSG00000085377 'PREP intron_variant 0.999067 rs12192054 ENSG00000085377 'PREP missense_variant ENSG00000085377 ENSG00000085377 'PREP 3 novel specific_protein PREP chr6 105273218 105454062 -1 5550 protein_coding 6:105327913 126149 220_2_2 SeqId_18180_58 'RT4I1 chr6:107077502_A_G$SeqId_18180_58 1 chr6:107077502_A_G rs2054365 cis 6 107077502 A G 0.4033 0.1657 0.0123 1.18e-41 'Reticulon-4-interacting protein 1, mitochondrial ENSG00000130347 'RTN4IP1 5_prime_UTR_variant ENSG00000130347 ENSG00000130347 'RTN4IP1 3 novel specific_protein RTN4IP1 chr6 106570771 106629498 -1 84816 protein_coding 6:106629627 129 221_1_1 SeqId_9470_15 'MET24 chr6:110681879_A_G$SeqId_9470_15 1 chr6:110681879_A_G rs12664330 cis 6 110681879 A G 0.6393 0.118 0.0138 1.43e-17 'Methyltransferase-like protein 24 ENSG00000053328 'METTL24 upstream_gene_variant ENSG00000053328 ENSG00000053328 'METTL24 3 novel specific_protein METTL24 chr6 110243940 110358349 -1 728464 protein_coding 6:110360676 2327 222_1_2 SeqId_15653_9 'COAA1 chr6:116464219_A_T$SeqId_15653_9 1 chr6:116464219_A_T rs34224224 cis 6 116464219 A T 0.7343 0.3522 0.0147 4.54e-127 'Collagen alpha-1(X) chain ENSG00000123500 'COL10A1 intron_variant 0.5765 rs1064583 ENSG00000123500 'COL10A1 missense_variant ENSG00000123500 ENSG00000123500 'COL10A1 3 novel specific_protein COL10A1 chr6 116118909 116158747 -1 1300 protein_coding 6:116143056 15691 222_1_4 SeqId_5631_83 'MOTI chr6:117280434_C_T$SeqId_5631_83 1 chr6:117280434_C_T rs1761832 trans 6 117280434 T C 0.8151 -0.1161 0.0163 1.19e-12 'Promotilin ENSG00000096395 'MLN intergenic_variant 0.245202 rs2274911 ENSG00000173612 'GPRC6A missense_variant none none ' novel suggestive_specific_pathway MLN chr6 33794673 33804003 -1 4295 protein_coding 6:116959271 83155268 223_1_1 SeqId_18172_71 'ASF1A chr6:119215902_C_G$SeqId_18172_71 1 chr6:119215902_C_G rs147886588 cis 6 119215902 C G 0.8292 -0.2808 0.017 3.3e-61 'Histone chaperone ASF1A ENSG00000111875 'ASF1A intron_variant ENSG00000111875 ENSG00000111875 'ASF1A 3 novel specific_protein ASF1A chr6 118894152 118909171 1 25842 protein_coding 6:118894738 586 224_1_2 SeqId_4771_10 'ASM3A chr6:123122464_C_T$SeqId_4771_10 1 chr6:123122464_C_T rs28385609 cis 6 123122464 T C 0.1438 -0.354 0.0181 8.78e-85 'Acid sphingomyelinase-like phosphodiesterase 3a ENSG00000172594 'SMPDL3A missense_variant ENSG00000172594 ENSG00000172594 'SMPDL3A 3 known specific_protein SMPDL3A chr6 122789049 122809720 1 10924 protein_coding 6:122801319 12270 225_1_1 SeqId_8427_118 'RSPO3 chr6:127481154_A_C$SeqId_8427_118 1 chr6:127481154_A_C rs4644087 cis 6 127481154 A C 0.4456 -0.3385 0.0126 5.75e-158 'R-spondin-3 ENSG00000146374 'RSPO3 intron_variant ENSG00000146374 ENSG00000146374 'RSPO3 4 known suggestive_specific_pathway -0.17354 0.063058 0.00614610534719524 yes RSPO3 Olink ONCOLOGY II(v.7002) RSPO3 chr6 127118671 127199481 1 84870 protein_coding 6:127160009 41338 225_1_1 SeqId_13094_75 'RSPO3 chr6:127478585_D_I$SeqId_13094_75 1 chr6:127478585_D_I rs58617845 cis 6 127478585 D I 0.4454 -0.2955 0.013 1.06e-114 'R-spondin-3 ENSG00000146374 'RSPO3 intron_variant ENSG00000146374 ENSG00000146374 'RSPO3 4 known suggestive_specific_pathway -0.17544 0.063087 0.00563248443171473 yes RSPO3 Olink ONCOLOGY II(v.7002) RSPO3 chr6 127118671 127199481 1 84870 protein_coding 6:127157441 38770 226_1_1 SeqId_18347_15 'Laminin-2 chr6:129571330_A_G$SeqId_18347_15 1 chr6:129571330_A_G rs3816665 cis 6 129571330 A G 0.1335 -0.2885 0.0195 1.16e-49 'Laminin-2 ENSG00000091136|ENSG00000135862|ENSG00000196569 'LAMB1|LAMC1|LAMA2 missense_variant ENSG00000091136|ENSG00000135862|ENSG00000196569 ENSG00000091136|ENSG00000135862|ENSG00000196569 'LAMA2|LAMB1|LAMC1 3 novel specific_protein LAMA2 chr6 128883138 129516566 1 3908 protein_coding 6:129250185 367047 227_1_1 SeqId_8274_64 'Syntaxin-7 chr6:132833954_C_G$SeqId_8274_64 1 chr6:132833954_C_G rs12190479 cis 6 132833954 C G 0.1961 0.2099 0.0168 7.58e-36 'Syntaxin-7 ENSG00000079950 'STX7 intron_variant ENSG00000079950 ENSG00000079950 'STX7 3 novel specific_protein STX7 chr6 132445867 132513198 -1 8417 protein_coding 6:132512815 383 227_1_2 SeqId_15480_2 'VNN2 chr6:133074133_A_G$SeqId_15480_2 1 chr6:133074133_A_G rs9493423 cis 6 133074133 A G 0.341 -0.7208 0.0118 7.32e-813 'Vascular non-inflammatory molecule 2 ENSG00000112303 'VNN2 intron_variant ENSG00000112303 ENSG00000112303 'VNN2 3 novel specific_protein VNN2 chr6 132743870 132763459 -1 8875 protein_coding 6:132752994 10465 229_1_4 SeqId_5087_5 'IL-22BP chr6:137540520_A_G$SeqId_5087_5 1 chr6:137540520_A_G rs2234711 cis 6 137540520 A G 0.6162 -0.1239 0.0137 1.24e-19 'Interleukin-22 receptor subunit alpha-2 ENSG00000164485 'IL22RA2 5_prime_UTR_variant ENSG00000164485 ENSG00000164485 'IL22RA2 3 novel specific_protein IL22RA2 chr6 137143820 137173648 -1 116379 protein_coding 6:137219383 45735 229_2_1 SeqId_14009_65 'TNFAIP3 chr6:138186532_A_G$SeqId_14009_65 1 chr6:138186532_A_G rs59693083 cis 6 138186532 A G 0.9179 -0.4334 0.0233 3.47e-77 'Tumor necrosis factor alpha-induced protein 3 ENSG00000118503 'TNFAIP3 upstream_gene_variant 0.375384 rs2230926 ENSG00000118503 'TNFAIP3 missense_variant ENSG00000118503 ENSG00000118503 'TNFAIP3 3 novel specific_protein TNFAIP3 chr6 137867214 137883312 1 7128 protein_coding 6:137865395 1819 23_1_1 SeqId_10938_13 'sLFA-3 chr1:117078729_A_G$SeqId_10938_13 1 chr1:117078729_A_G rs35768283 cis 1 117078729 A G 0.9821 -1.3819 0.0503 4.97e-166 'Lymphocyte function-associated antigen 3 ENSG00000116815 'CD58 synonymous_variant ENSG00000116815 ENSG00000116815 'CD58 3 known specific_protein 0.068694 0.30196 0.820138123092504 no CD58 Olink DEVELOPMENT(v.3511) CD58 chr1 116514534 116571039 -1 965 protein_coding 1:116536107 34932 23_1_2 SeqId_12727_7 'FPRP chr1:117490261_G_T$SeqId_12727_7 1 chr1:117490261_G_T rs4233450 cis 1 117490261 T G 0.828 0.7066 0.0159 2.52e-431 'Prostaglandin F2 receptor negative regulator ENSG00000134247 'PTGFRN intron_variant 0.450963 rs4546904 ENSG00000134247 'PTGFRN missense_variant ENSG00000134247 ENSG00000134247 'PTGFRN 3 known specific_protein PTGFRN chr1 116909916 116990353 1 5738 protein_coding 1:116947639 37723 23_1_3 SeqId_9077_10 'MA1A2 chr1:117969780_D_I$SeqId_9077_10 1 chr1:117969780_D_I rs35505705 cis 1 117969780 D I 0.2376 -0.3439 0.0154 3.62e-110 'Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB ENSG00000198162 'MAN1A2 intron_variant ENSG00000198162 ENSG00000198162 'MAN1A2 3 known specific_protein MAN1A2 chr1 117367449 117528872 1 10905 protein_coding 1:117427159 59710 230_1_1 SeqId_13374_4 'DB113 chr6:143859014_A_C$SeqId_13374_4 1 chr6:143859014_A_C rs9403501 trans 6 143859014 A C 0.202 0.2027 0.0167 9.32e-34 'Beta-defensin 113 ENSG00000214642 'DEFB113 intron_variant ENSG00000112419 ENSG00000112419|ENSG00000169976 'PHACTR2|SF3B5 1 novel unspecific_effect DEFB113 chr6 49968677 49969625 -1 245927 protein_coding 6:143537877 93568252 231_1_1 SeqId_8364_74 'UST chr6:149079394_A_G$SeqId_8364_74 1 chr6:149079394_A_G rs11757768 cis 6 149079394 A G 0.4135 0.2845 0.0132 2.38e-102 'Uronyl 2-sulfotransferase ENSG00000111962 'UST intron_variant ENSG00000111962 ENSG00000111962 'UST 3 known specific_protein UST chr6 148747030 149076990 1 10090 protein_coding 6:148758258 11228 231_1_2 SeqId_15472_16 'LRP11 chr6:150110857_D_I$SeqId_15472_16 1 chr6:150110857_D_I rs10544441 cis 6 150110857 D I 0.3617 0.8038 0.0116 2.64e-1045 'Low-density lipoprotein receptor-related protein 11 ENSG00000120256 'LRP11 intron_variant 0.60223 rs9322225 ENSG00000120256 'LRP11 missense_variant ENSG00000120256 ENSG00000120256 'LRP11 3 known specific_protein 0.53534 0.058434 1.46217717445672e-18 yes LRP11 Olink METABOLISM(v.3402) LRP11 chr6 149818757 149864359 -1 84918 protein_coding 6:149789722 74637 231_1_3 SeqId_6713_4 'LRP11 chr6:150184882_C_G$SeqId_6713_4 1 chr6:150184882_C_G rs9322225 cis 6 150184882 C G 0.3943 0.8699 0.0108 1.62e-1411 'Low-density lipoprotein receptor-related protein 11 ENSG00000120256 'LRP11 missense_variant ENSG00000120256 ENSG00000120256 'LRP11 3 known specific_protein 0.27081 0.062248 1.65882281537505e-05 yes LRP11 Olink METABOLISM(v.3402) LRP11 chr6 149818757 149864359 -1 84918 protein_coding 6:149863746 613 232_1_1 SeqId_11134_30 'RF1ML chr6:153323142_C_T$SeqId_11134_30 1 chr6:153323142_C_T rs12206911 cis 6 153323142 T C 0.1897 -0.7084 0.0145 8.31e-521 'Peptide chain release factor 1-like, mitochondrial ENSG00000112031 'MTRF1L intron_variant 0.992428 rs3192723 ENSG00000112031 'MTRF1L missense_variant ENSG00000112031 ENSG00000112031 'MTRF1L 3 known specific_protein MTRF1L chr6 152987362 153002709 -1 54516 protein_coding 6:153002007 702 233_1_1 SeqId_17341_89 'THIC chr6:160196343_A_G$SeqId_17341_89 1 chr6:160196343_A_G rs25683 cis 6 160196343 A G 0.4297 0.4387 0.0118 7.36e-301 'Acetyl-CoA acetyltransferase, cytosolic ENSG00000120437 'ACAT2 missense_variant ENSG00000120437 ENSG00000120437 'ACAT2 3 novel specific_protein ACAT2 chr6 159762045 159779112 1 39 protein_coding 6:159775311 13266 233_1_2 SeqId_16057_6 'IGF-II receptor chr6:160498049_A_G$SeqId_16057_6 1 chr6:160498049_A_G rs3777404 cis 6 160498049 A G 0.1322 0.8285 0.0183 1.47e-447 'Cation-independent mannose-6-phosphate receptor ENSG00000197081 'IGF2R intron_variant 0.109604 rs8191754 ENSG00000197081 'IGF2R missense_variant ENSG00000197081 ENSG00000197081 'IGF2R 3 known specific_protein 0.47772 0.092934 3.98565772313401e-07 yes IGF2R Olink DEVELOPMENT(v.3511) IGF2R chr6 159969082 160113507 1 3482 protein_coding 6:160077017 107935 233_2_1 SeqId_4151_6 'Plasminogen chr6:161214795_C_G$SeqId_4151_6 1 chr6:161214795_C_G rs144981713 cis 6 161214795 C G 0.0139 -1.6279 0.0575 2.83e-176 'Plasminogen ENSG00000122194 'PLG intergenic_variant 0.909291 rs4252129 ENSG00000122194 'PLG missense_variant ENSG00000122194 ENSG00000122194 'PLG 7 known suggestive_specific_pathway PLG chr6 160702238 160754097 1 5340 protein_coding 6:160793763 91525 233_2_2 SeqId_17792_158 'SSDH chr6:161155264_C_T$SeqId_17792_158 1 chr6:161155264_C_T rs537579467 trans 6 161155264 T C 0.9853 -0.8459 0.0583 1.09e-47 'Succinate-semialdehyde dehydrogenase, mitochondrial ENSG00000112294 'ALDH5A1 intron_variant 0.980203 rs143079629 ENSG00000122194 'PLG missense_variant ENSG00000122194 ENSG00000122194 'PLG 6 known unspecific_effect ALDH5A1 chr6 24494867 24537207 1 7915 protein_coding 6:160734232 136239365 233_2_2 SeqId_3710_49 'Angiostatin chr6:161155264_C_T$SeqId_3710_49 1 chr6:161155264_C_T rs537579467 cis 6 161155264 T C 0.9853 -1.5632 0.0549 2.03e-178 'Angiostatin ENSG00000122194 'PLG intron_variant 0.980203 rs143079629 ENSG00000122194 'PLG missense_variant ENSG00000122194 ENSG00000122194 'PLG 6 known unspecific_effect PLG chr6 160702238 160754097 1 5340 protein_coding 6:160734232 31994 234_1_1 SeqId_16913_8 'RNT2 chr6:167343141_A_G$SeqId_16913_8 1 chr6:167343141_A_G rs11159 cis 6 167343141 A G 0.0746 -0.6364 0.0247 6.74e-146 'Ribonuclease T2 ENSG00000026297 'RNASET2 missense_variant ENSG00000026297 ENSG00000026297 'RNASET2 3 novel specific_protein RNASET2 chr6 166922113 166957191 -1 8635 protein_coding 6:166929653 27538 235_1_1 SeqId_15635_4 'SMOC2 chr6:168818164_G_T$SeqId_15635_4 1 chr6:168818164_G_T rs4708738 cis 6 168818164 T G 0.2756 -0.4179 0.0141 7.73e-193 'SPARC-related modular calcium-binding protein 2 ENSG00000112562 'SMOC2 regulatory_region_variant ENSG00000112562 ENSG00000112562 'SMOC2 3 novel specific_protein -0.44379 0.066617 7.43019137896702e-11 yes SMOC2 Olink NEUROLOGY(v.8011) SMOC2 chr6 168441151 168673445 1 64094 protein_coding 6:168417484 23667 235_2_1 SeqId_3339_33 'TSP2 chr6:169624770_A_G$SeqId_3339_33 1 chr6:169624770_A_G rs74507247 cis 6 169624770 A G 0.0988 0.7519 0.0203 4.19e-299 'Thrombospondin-2 ENSG00000186340 'THBS2 intron_variant ENSG00000186340 ENSG00000186340 'THBS2 3 known unspecific_effect 0.80839 0.098398 1.97242273611485e-15 yes THBS2 Olink CARDIOVASCULAR II(v.5004) THBS2 chr6 169215780 169254050 -1 7058 protein_coding 6:169224675 29375 235_2_1 SeqId_14111_15 'TSP2 chr6:169624770_A_G$SeqId_14111_15 1 chr6:169624770_A_G rs74507247 cis 6 169624770 A G 0.0987 0.2143 0.0227 3.47e-21 'Thrombospondin-2 ENSG00000186340 'THBS2 intron_variant ENSG00000186340 ENSG00000186340 'THBS2 3 known unspecific_effect THBS2 chr6 169215780 169254050 -1 7058 protein_coding 6:169224675 29375 235_3_1 SeqId_5349_69 'DLL1 chr6:170588232_A_C$SeqId_5349_69 1 chr6:170588232_A_C rs4710790 cis 6 170588232 A C 0.578 -0.147 0.0138 2.44e-26 'Delta-like protein 1 ENSG00000198719 'DLL1 downstream_gene_variant ENSG00000198719 ENSG00000198719 'DLL1 3 known specific_protein DLL1 chr6 170282206 170306565 -1 28514 protein_coding 6:170279144 27421 235_3_2 SeqId_12612_37 'PSB1 chr6:170888362_D_I$SeqId_12612_37 1 chr6:170888362_D_I rs17860826 cis 6 170888362 D I 0.4077 -0.3333 0.0128 7.39e-150 'Proteasome subunit beta type-1 ENSG00000008018 'PSMB1 intron_variant 0.999303 rs12717 ENSG00000008018 'PSMB1 missense_variant ENSG00000008018 ENSG00000008018 'PSMB1 3 known specific_protein PSMB1 chr6 170535120 170553307 -1 5689 protein_coding 6:170579275 25968 236_1_1 SeqId_13618_15 'MD1L1 chr7:2258899_A_G$SeqId_13618_15 1 chr7:2258899_A_G rs1639916 cis 7 2258899 A G 0.6458 0.1249 0.014 4.4e-19 'Mitotic spindle assembly checkpoint protein MAD1 ENSG00000002822 'MAD1L1 intron_variant ENSG00000002822 ENSG00000002822 'MAD1L1 3 novel unspecific_effect MAD1L1 chr7 1815793 2233243 -1 8379 protein_coding 7:2219264 13979 236_1_2 SeqId_6925_26 'SNX8 chr7:2290295_A_G$SeqId_6925_26 1 chr7:2290295_A_G rs34750471 cis 7 2290295 A G 0.0122 -1.0254 0.0595 1.54e-66 'Sorting nexin-8 ENSG00000106266 'SNX8 intron_variant ENSG00000106266 ENSG00000106266 'SNX8 3 novel unspecific_effect SNX8 chr7 2251770 2354318 -1 29886 protein_coding 7:2250660 103658 236_1_3 SeqId_19206_20 '8ODP chr7:2292617_D_I$SeqId_19206_20 1 chr7:2292617_D_I rs143499401 cis 7 2292617 D I 0.0197 -0.6736 0.0497 8.67e-42 '7,8-dihydro-8-oxoguanine triphosphatase ENSG00000106268 'NUDT1 3_prime_UTR_variant 0.37031 rs4866 ENSG00000106268 'NUDT1 missense_variant ENSG00000106268 ENSG00000106268 'NUDT1 3 novel unspecific_effect NUDT1 chr7 2242226 2251146 1 4521 protein_coding 7:2252983 10757 236_1_4 SeqId_6626_81 'CHSTC chr7:2410567_G_T$SeqId_6626_81 1 chr7:2410567_G_T 7:2410567_G_T cis 7 2410567 T G 0.2121 0.2113 0.016 7.47e-40 'Carbohydrate sulfotransferase 12 ENSG00000136213 'CHST12 intron_variant ENSG00000136213 ENSG00000136213 'CHST12 3 known specific_protein CHST12 chr7 2403588 2448484 1 55501 protein_coding 7:2370932 32656 238_1_1 SeqId_8687_26 'T106B chr7:12268717_C_T$SeqId_8687_26 1 chr7:12268717_C_T rs5011434 cis 7 12268717 T C 0.417 -0.221 0.0136 5.79e-59 'Transmembrane protein 106B ENSG00000106460 'TMEM106B intron_variant 0.999077 rs3173615 ENSG00000106460 'TMEM106B missense_variant ENSG00000106460 ENSG00000106460 'TMEM106B 3 known specific_protein TMEM106B chr7 12211270 12243367 1 54664 protein_coding 7:12229091 17821 238_1_2 SeqId_12684_5 'ADSV chr7:12629620_D_I$SeqId_12684_5 1 chr7:12629620_D_I rs56357458 cis 7 12629620 D I 0.408 -0.1318 0.0134 9.64e-23 'Adseverin ENSG00000006747 'SCIN intron_variant 0.915806 rs2240572 ENSG00000006747 'SCIN missense_variant ENSG00000006747 ENSG00000006747 'SCIN 3 novel specific_protein SCIN chr7 12570577 12660182 1 85477 protein_coding 7:12589996 19419 239_1_1 SeqId_11237_49 'PCOC1 chr7:21611187_C_G$SeqId_11237_49 1 chr7:21611187_C_G rs73066481 trans 7 21611187 C G 0.2157 -0.1145 0.0159 6.74e-13 'Procollagen C-endopeptidase enhancer 1 ENSG00000106333 'PCOLCE intron_variant 0.177713 rs2285943 ENSG00000105877 'DNAH11 stop_gained none none ' novel suggestive_specific_pathway PCOLCE chr7 100602363 100608175 1 5118 protein_coding 7:21571569 79030794 24_1_2 SeqId_11102_22 'REG4 chr1:120359286_A_C$SeqId_11102_22 1 chr1:120359286_A_C rs79795228 cis 1 120359286 A C 0.0175 0.4684 0.0515 1.0e-19 'Regenerating islet-derived protein 4 ENSG00000134193 'REG4 regulatory_region_variant ENSG00000134193 ENSG00000134193 'REG4 3 known specific_protein 0.9319 0.24029 0.000119811912319003 yes REG4 Olink METABOLISM(v.3402) REG4 chr1 119794017 119811580 -1 83998 protein_coding 1:119816663 5083 240_1_1 SeqId_8289_8 'GPNMB chr7:23292808_C_T$SeqId_8289_8 1 chr7:23292808_C_T rs1881203 cis 7 23292808 T C 0.6228 0.2955 0.0136 4.46e-105 'Transmembrane glycoprotein NMB ENSG00000136235 'GPNMB intron_variant ENSG00000136235 ENSG00000136235 'GPNMB 3 known specific_protein 0.20114 0.060102 0.000881657690262191 yes GPNMB Olink NEURO EXPLORATORY(v.3901) GPNMB chr7 23235967 23275108 1 10457 protein_coding 7:23253189 17222 240_1_2 SeqId_8606_39 'GPNMB chr7:23313171_C_T$SeqId_8606_39 1 chr7:23313171_C_T rs2268748 cis 7 23313171 T C 0.9594 -0.6425 0.0328 3.16e-85 'Transmembrane glycoprotein NMB ENSG00000136235 'GPNMB synonymous_variant ENSG00000136235 ENSG00000136235 'GPNMB 3 known specific_protein -0.21397 0.14837 0.149906339694328 no GPNMB Olink NEURO EXPLORATORY(v.3901) GPNMB chr7 23235967 23275108 1 10457 protein_coding 7:23273552 37585 240_2_1 SeqId_6388_21 'CC126 chr7:23634985_A_G$SeqId_6388_21 1 chr7:23634985_A_G rs35121828 cis 7 23634985 A G 0.2545 0.3763 0.0149 1.29e-140 'Coiled-coil domain-containing protein 126 ENSG00000169193 'CCDC126 upstream_gene_variant ENSG00000169193 ENSG00000169193 'CCDC126 3 known specific_protein CCDC126 chr7 23597382 23644708 1 90693 protein_coding 7:23595366 2016 241_1_1 SeqId_19615_213 '5NT3 chr7:33070605_A_G$SeqId_19615_213 1 chr7:33070605_A_G rs7798138 cis 7 33070605 A G 0.7042 -0.1031 0.0139 1.46e-13 'Cytosolic 5'-nucleotidase 3A ENSG00000122643 'NT5C3A intron_variant ENSG00000122643 ENSG00000122643 'NT5C3A 3 novel specific_protein NT5C3A chr7 33014130 33062796 -1 51251 protein_coding 7:33030993 31803 241_2_1 SeqId_15368_3 'BMPER chr7:33804485_A_G$SeqId_15368_3 1 chr7:33804485_A_G rs16879245 cis 7 33804485 A G 0.9201 0.2155 0.0241 3.61e-19 'BMP-binding endothelial regulator protein ENSG00000164619 'BMPER TF_binding_site_variant ENSG00000164619 ENSG00000164619 'BMPER 3 novel specific_protein BMPER chr7 33904308 34156427 1 168667 protein_coding 7:33764873 139435 242_1_1 SeqId_12764_3 'ELMO1 chr7:37461507_C_G$SeqId_12764_3 1 chr7:37461507_C_G rs79483315 cis 7 37461507 C G 0.9333 0.3494 0.0278 3.62e-36 'Engulfment and cell motility protein 1 ENSG00000155849 'ELMO1 intron_variant ENSG00000155849 ENSG00000155849 'ELMO1 3 novel specific_protein ELMO1 chr7 36852906 37449223 -1 9844 protein_coding 7:37421904 27319 242_2_1 SeqId_17447_52 'SFRP4 chr7:37972390_A_T$SeqId_17447_52 1 chr7:37972390_A_T rs75207237 cis 7 37972390 A T 0.1256 0.2772 0.0186 4.72e-50 'Secreted frizzled-related protein 4 ENSG00000106483 'SFRP4 intron_variant ENSG00000106483 ENSG00000106483 'SFRP4 3 known specific_protein SFRP4 chr7 37905932 38025695 -1 6424 protein_coding 7:37932788 92907 243_1_1 SeqId_4978_54 'DBNL chr7:44077470_C_T$SeqId_4978_54 1 chr7:44077470_C_T rs56665454 cis 7 44077470 T C 0.3261 0.1097 0.0134 2.4e-16 'Drebrin-like protein ENSG00000136279 'DBNL intron_variant ENSG00000136279 ENSG00000136279 'DBNL 3 novel specific_protein DBNL chr7 44044640 44069456 1 28988 protein_coding 7:44037871 6769 243_1_2 SeqId_12851_5 'DPOLM chr7:44113855_C_G$SeqId_12851_5 1 chr7:44113855_C_G rs142059440 cis 7 44113855 C G 0.0134 0.7037 0.0594 2.02e-32 'DNA-directed DNA/RNA polymerase mu ENSG00000122678 'POLM intron_variant ENSG00000122678 ENSG00000122678 'POLM 3 novel specific_protein POLM chr7 44072062 44082530 -1 27434 protein_coding 7:44074256 8274 243_1_4 SeqId_4254_6 'NUDC3 chr7:44502186_C_T$SeqId_4254_6 1 chr7:44502186_C_T rs10233273 cis 7 44502186 T C 0.229 0.2434 0.0152 7.44e-58 'NudC domain-containing protein 3 ENSG00000015676 'NUDCD3 intron_variant 0.990882 rs307007 ENSG00000015676 'NUDCD3 missense_variant ENSG00000015676 ENSG00000015676 'NUDCD3 3 novel specific_protein NUDCD3 chr7 44379119 44490658 -1 23386 protein_coding 7:44462587 28071 243_2_1 SeqId_12347_29 'CCM2 chr7:45031315_C_T$SeqId_12347_29 1 chr7:45031315_C_T rs7805382 cis 7 45031315 T C 0.2205 0.1449 0.0152 1.4e-21 'Cerebral cavernous malformations 2 protein ENSG00000136280 'CCM2 upstream_gene_variant ENSG00000136280 ENSG00000136280 'CCM2 3 novel suggestive_specific_pathway CCM2 chr7 44999475 45076469 1 83605 protein_coding 7:44991716 7759 243_2_3 SeqId_2771_35 'IGFBP-1 chr7:45915378_D_I$SeqId_2771_35 1 chr7:45915378_D_I rs10577484 cis 7 45915378 D I 0.5059 -0.0909 0.0128 1.04e-12 'Insulin-like growth factor-binding protein 1 ENSG00000146678 'IGFBP1 regulatory_region_variant 0.47839 rs4619 ENSG00000146678 'IGFBP1 missense_variant ENSG00000146678 ENSG00000146678 'IGFBP1 3 novel suggestive_specific_pathway IGFBP1 chr7 45888360 45893660 1 3484 protein_coding 7:45875780 12580 243_3_3 SeqId_2571_12 'IGFBP-3 chr7:45954465_A_G$SeqId_2571_12 1 chr7:45954465_A_G rs145188037 cis 7 45954465 A G 0.0124 1.2659 0.0551 1.05e-116 'Insulin-like growth factor-binding protein 3 ENSG00000146674 'IGFBP3 missense_variant ENSG00000146674 ENSG00000146674 'IGFBP3 3 known specific_protein -0.32239 0.34255 0.347088320551565 no IGFBP3 Olink CARDIOMETABOLIC(v.3602) IGFBP3 chr7 45912245 45921874 -1 3486 protein_coding 7:45914866 7008 244_1_1 SeqId_19448_104 'UPP1 chr7:47987296_A_G$SeqId_19448_104 1 chr7:47987296_A_G rs6463455 cis 7 47987296 A G 0.2091 0.1771 0.0156 1.06e-29 'Uridine phosphorylase 1 ENSG00000183696 'UPP1 intron_variant ENSG00000183696 ENSG00000183696 'UPP1 3 novel specific_protein UPP1 chr7 48088628 48108736 1 7378 protein_coding 7:47947699 140929 245_1_2 SeqId_15308_108 'VWC2 chr7:49819462_A_C$SeqId_15308_108 1 chr7:49819462_A_C rs1974955 cis 7 49819462 A C 0.4594 -0.2511 0.0122 1.6e-94 'Brorin ENSG00000188730 'VWC2 intron_variant 0.991067 rs769604 ENSG00000188730 'VWC2 missense_variant ENSG00000188730 ENSG00000188730 'VWC2 3 known specific_protein -0.42565 0.058516 1.4288939585111e-12 yes VWC2 Olink NEUROLOGY(v.8011) VWC2 chr7 49773638 49921950 1 375567 protein_coding 7:49779866 6228 245_1_3 SeqId_3538_26 'dopa decarboxylase chr7:50620781_C_T$SeqId_3538_26 1 chr7:50620781_C_T rs6956737 cis 7 50620781 T C 0.0152 -0.4523 0.056 6.48e-16 'Aromatic-L-amino-acid decarboxylase ENSG00000132437 'DDC intron_variant 0.872076 rs11575542 ENSG00000132437 'DDC missense_variant ENSG00000132437 ENSG00000132437 'DDC 3 known specific_protein DDC chr7 50458436 50565405 -1 1644 protein_coding 7:50553083 12322 246_1_1 SeqId_2677_1 'ERBB1 chr7:55235804_A_C$SeqId_2677_1 1 chr7:55235804_A_C rs12669749 cis 7 55235804 A C 0.1156 0.1772 0.0206 8.76e-18 'Epidermal growth factor receptor ENSG00000146648 'EGFR intron_variant ENSG00000146648 ENSG00000146648 'EGFR 3 novel specific_protein EGFR chr7 55019017 55211628 1 1956 protein_coding 7:55168111 149094 248_2_1 SeqId_15562_24 'BGLR chr7:65425894_A_G$SeqId_15562_24 1 chr7:65425894_A_G rs9530 cis 7 65425894 A G 0.4453 -0.1466 0.0125 6.59e-32 'Beta-glucuronidase ENSG00000169919 'GUSB missense_variant ENSG00000169919 ENSG00000169919 'GUSB 3 known unspecific_effect GUSB chr7 65960684 65982215 -1 2990 protein_coding 7:65960907 21308 248_3_1 SeqId_3866_7 'SBDS chr7:66453476_A_G$SeqId_3866_7 1 chr7:66453476_A_G rs79344818 cis 7 66453476 A G 0.9605 0.4005 0.033 7.12e-34 'Ribosome maturation protein SBDS ENSG00000126524 'SBDS missense_variant ENSG00000126524 ENSG00000126524 'SBDS 6 novel specific_pathway SBDS chr7 66987680 66995586 -1 51119 protein_coding 7:66988489 7097 248_3_2 SeqId_7928_183 'TPST1 chr7:65713666_G_T$SeqId_7928_183 1 chr7:65713666_G_T rs12537083 cis 7 65713666 T G 0.6983 0.2301 0.0136 4.25e-64 'Protein-tyrosine sulfotransferase 1 ENSG00000169902 'TPST1 intron_variant ENSG00000169902 ENSG00000169902 'TPST1 3 known unspecific_effect TPST1 chr7 66205317 66420543 1 8460 protein_coding 7:66248679 43362 248_3_3 SeqId_11241_8 'ARLY chr7:65726615_C_T$SeqId_11241_8 1 chr7:65726615_C_T rs4145009 cis 7 65726615 T C 0.3714 -0.1529 0.0131 2.21e-31 'Argininosuccinate lyase ENSG00000126522 'ASL intron_variant ENSG00000126522 ENSG00000126522 'ASL 3 known unspecific_effect ASL chr7 66075800 66094697 1 435 protein_coding 7:66261628 185828 249_1_3 SeqId_17766_5 'NCF-1 chr7:72337438_C_T$SeqId_17766_5 1 chr7:72337438_C_T 7:72337438_C_T trans 7 72337438 T C 0.0134 -0.4994 0.0616 4.98e-16 'Neutrophil cytosol factor 1 ENSG00000158517 'NCF1 intron_variant 0.727321 rs139225348 ENSG00000158517 'NCF1 missense_variant ENSG00000179994 ENSG00000179994 ' 1 known specific_protein NCF1 chr7 74774011 74789315 1 653361 protein_coding 7:72866873 1907138 249_1_4 SeqId_7866_11 'DJC30 chr7:73109967_D_I$SeqId_7866_11 1 chr7:73109967_D_I 7:73109967_D_I cis 7 73109967 D I 0.9586 -0.2589 0.0325 1.68e-15 'DnaJ homolog subfamily C member 30 ENSG00000176410 'DNAJC30 intron_variant 0.99264 rs61751896 ENSG00000176410 'DNAJC30 missense_variant ENSG00000176410 ENSG00000176410 'DNAJC30 3 known specific_protein DNAJC30 chr7 73680918 73683453 -1 84277 protein_coding 7:73695637 12184 249_2_2 SeqId_17766_5 'NCF-1 chr7:75131187_C_T$SeqId_17766_5 1 chr7:75131187_C_T rs201862093 trans 7 75131187 T C 0.1045 0.5001 0.0226 5.65e-109 'Neutrophil cytosol factor 1 ENSG00000158517 'NCF1 intron_variant 0.774154 rs113744930 ENSG00000135213 'POM121C missense_variant ENSG00000170092|ENSG00000127946 ENSG00000158517 'NCF1 4 novel specific_protein NCF1 chr7 74774011 74789315 1 653361 protein_coding 7:75501863 727852 249_2_4 SeqId_2731_29 'NADPH-P450 Oxidoreductase chr7:75638421_A_G$SeqId_2731_29 1 chr7:75638421_A_G rs59882870 cis 7 75638421 A G 0.1602 0.673 0.0172 7.22e-335 'NADPH--cytochrome P450 reductase ENSG00000127948 'POR intron_variant 0.434769 rs1057868 ENSG00000127948 'POR missense_variant ENSG00000127948 ENSG00000127948 'POR 3 novel suggestive_specific_pathway POR chr7 75899200 75986855 1 5447 protein_coding 7:76009103 109903 249_2_5 SeqId_11103_24 'HSP 27 chr7:75924218_G_T$SeqId_11103_24 1 chr7:75924218_G_T rs2908203_G_T cis 7 75924218 T G 0.2501 -0.6897 0.0137 7.19e-553 'Heat shock protein beta-1 ENSG00000106211 'HSPB1 TF_binding_site_variant ENSG00000106211 ENSG00000106211 'HSPB1 3 known suggestive_specific_pathway 0.4235 0.06942 2.17520403401952e-09 no HSP 27 Olink CARDIOVASCULAR II(v.5004) HSPB1 chr7 76302673 76304295 1 3315 protein_coding 7:76294901 7772 25_1_1 SeqId_3332_57 'RGM-C chr1:145477223_A_G$SeqId_3332_57 1 chr1:145477223_A_G rs113404160 cis 1 145477223 A G 0.0146 -0.6052 0.0617 1.09e-22 'Hemojuvelin ENSG00000168509 'HFE2 missense_variant ENSG00000168509 ENSG00000168509 'HJV 3 novel specific_pathway HJV chr1 146017468 146036746 -1 148738 protein_coding 1:145957863 78883 25_1_2 SeqId_5742_14 'PPA6 chr1:147124310_G_T$SeqId_5742_14 1 chr1:147124310_G_T rs2153463 cis 1 147124310 T G 0.3006 -0.9604 0.0117 6.99e-1466 'Lysophosphatidic acid phosphatase type 6 ENSG00000162836 'ACP6 synonymous_variant ENSG00000162836 ENSG00000162836 'ACP6 3 known specific_protein -0.72266 0.062173 1.04231742939331e-27 yes ACP6 Olink METABOLISM(v.3402) ACP6 chr1 147629652 147670524 -1 51205 protein_coding 1:147652507 18017 25_2_1 SeqId_12880_1 'SV2A chr1:149898951_C_G$SeqId_12880_1 1 chr1:149898951_C_G rs16836630 cis 1 149898951 C G 0.0779 -0.3763 0.0242 2.63e-54 'Synaptic vesicle glycoprotein 2A ENSG00000159164 'SV2A intron_variant ENSG00000159164 ENSG00000143368|ENSG00000159164|ENSG00000178096 'BOLA1|SF3B4|SV2A 3 known unspecific_effect SV2A chr1 149903318 149917844 -1 9900 protein_coding 1:149927059 9215 25_2_1 SeqId_13449_25 'SF3B4 chr1:149902588_A_G$SeqId_13449_25 1 chr1:149902588_A_G rs72692816 cis 1 149902588 A G 0.9225 0.1985 0.0251 2.74e-15 'Splicing factor 3B subunit 4 ENSG00000143368 'SF3B4 intron_variant ENSG00000143368 ENSG00000143368|ENSG00000159164|ENSG00000178096 'BOLA1|SF3B4|SV2A 3 known unspecific_effect SF3B4 chr1 149923317 149927803 -1 10262 protein_coding 1:149930696 2893 25_2_1 SeqId_15370_5 'BOLA1 chr1:149865880_A_G$SeqId_15370_5 1 chr1:149865880_A_G rs1451641 cis 1 149865880 A G 0.9216 -1.277 0.0211 5.58e-798 'BolA-like protein 1 ENSG00000178096 'BOLA1 intron_variant 0.996191 rs1044808 ENSG00000178096 'BOLA1 missense_variant ENSG00000178096 ENSG00000143368|ENSG00000159164|ENSG00000178096 'BOLA1|SF3B4|SV2A 3 known unspecific_effect BOLA1 chr1 149887890 149900798 1 51027 protein_coding 1:149894326 6436 25_2_3 SeqId_3366_51 'ECM1 chr1:150483355_C_T$SeqId_3366_51 1 chr1:150483355_C_T rs3737240 cis 1 150483355 T C 0.3984 -0.7059 0.012 5.25e-754 'Extracellular matrix protein 1 ENSG00000143369 'ECM1 missense_variant ENSG00000143369 ENSG00000143369 'ECM1 3 known unspecific_effect ECM1 chr1 150508062 150513789 1 1893 protein_coding 1:150510879 2817 25_2_4 SeqId_17738_7 'CRNN chr1:150496685_A_G$SeqId_17738_7 1 chr1:150496685_A_G rs141155234 trans 1 150496685 A G 0.0105 0.521 0.0704 1.4e-13 'Cornulin ENSG00000143536 'CRNN intergenic_variant 0.993992 rs151102225 ENSG00000143369 'ECM1 missense_variant ENSG00000143369 ENSG00000143369 'ECM1 2 novel unspecific_effect CRNN chr1 152409243 152414263 -1 49860 protein_coding 1:150524209 1890054 25_2_6 SeqId_17734_13 'a-endosulfine chr1:150527629_C_T$SeqId_17734_13 1 chr1:150527629_C_T rs111428433 cis 1 150527629 T C 0.0582 0.2502 0.0269 1.19e-20 'Alpha-endosulfine ENSG00000143420 'ENSA intron_variant ENSG00000143420 ENSG00000143420 'ENSA 3 novel unspecific_effect ENSA chr1 150600851 150629612 -1 2029 protein_coding 1:150555153 74459 25_2_7 SeqId_10396_6 'Mcl-1 chr1:150562043_A_C$SeqId_10396_6 1 chr1:150562043_A_C rs190596489 cis 1 150562043 A C 0.984 1.4688 0.0532 1.19e-167 'Induced myeloid leukemia cell differentiation protein Mcl-1 ENSG00000143384 'MCL1 intergenic_variant 1.0 rs11580946 ENSG00000143384 'MCL1 missense_variant ENSG00000143384 ENSG00000143384 'MCL1 3 known suggestive_specific_pathway MCL1 chr1 150560895 150579738 -1 4170 protein_coding 1:150589567 9829 25_2_8 SeqId_3181_50 'Cathepsin S chr1:150737220_A_G$SeqId_3181_50 1 chr1:150737220_A_G rs41271951 cis 1 150737220 A G 0.9181 0.6805 0.0223 3.87e-204 'Cathepsin S ENSG00000163131 'CTSS missense_variant ENSG00000163131 ENSG00000163131 'CTSS 3 known unspecific_effect 0.46095 0.10876 2.70271343194282e-05 yes CTSS Olink NEUROLOGY(v.8011) CTSS chr1 150730079 150765957 -1 1520 protein_coding 1:150764744 1213 25_2_9 SeqId_18340_2 'Proteasome beta chain chr1:151374025_C_T$SeqId_18340_2 1 chr1:151374025_C_T rs4603 cis 1 151374025 T C 0.8224 0.4932 0.0169 1.04e-186 'Proteasome subunit beta type-4 ENSG00000159377 'PSMB4 missense_variant ENSG00000159377 ENSG00000159377 'PSMB4 3 novel specific_protein PSMB4 chr1 151399560 151401937 1 5692 protein_coding 1:151401549 1989 25_3_1 SeqId_17738_7 'CRNN chr1:152391567_A_G$SeqId_17738_7 1 chr1:152391567_A_G rs10494275 cis 1 152391567 A G 0.0752 -0.4439 0.0257 7.27e-67 'Cornulin ENSG00000143536 'CRNN upstream_gene_variant 0.495293 rs3829868 ENSG00000143536 'CRNN missense_variant ENSG00000143536 ENSG00000143536 'CRNN 3 novel specific_protein -1.1711 0.10282 8.85115609830834e-27 yes CRNN Olink ONCOLOGY II(v.7002) CRNN chr1 152409243 152414263 -1 49860 protein_coding 1:152419091 4828 25_4_2 SeqId_15602_43 'IL-6 sRa chr1:154426970_A_C$SeqId_15602_43 1 chr1:154426970_A_C rs2228145 cis 1 154426970 A C 0.5956 -1.1352 0.0082 1.13e-4164 'Interleukin-6 receptor subunit alpha ENSG00000160712 'IL6R missense_variant ENSG00000160712 ENSG00000160712 'IL6R 8 known unspecific_effect -1.0295 0.041546 4.40554863506559e-88 yes IL-6RA Olink CARDIOVASCULAR III(v.6112) IL6R chr1 154405193 154469450 1 3570 protein_coding 1:154454494 49301 25_4_2 SeqId_4337_49 'CRP chr1:154426970_A_C$SeqId_4337_49 1 chr1:154426970_A_C rs2228145 trans 1 154426970 A C 0.5956 0.1076 0.0135 1.88e-15 'C-reactive protein ENSG00000132693 'CRP missense_variant ENSG00000160712 ENSG00000160712 'IL6R 8 known unspecific_effect CRP chr1 159712289 159714589 -1 1401 protein_coding 1:154454494 5260095 25_4_3 SeqId_17828_3 'S100A14 chr1:153590254_A_C$SeqId_17828_3 1 chr1:153590254_A_C rs9330298 cis 1 153590254 A C 0.4801 -0.1126 0.0136 1.52e-16 'Protein S100-A14 ENSG00000189334 'S100A14 upstream_gene_variant ENSG00000189334 ENSG00000188643|ENSG00000189334 'S100A14|S100A16 3 novel suggestive_specific_pathway S100A14 chr1 153614255 153616986 -1 57402 protein_coding 1:153617778 792 25_4_3 SeqId_17836_17 'S100A16 chr1:153596603_A_G$SeqId_17836_17 1 chr1:153596603_A_G rs35760493 cis 1 153596603 A G 0.4538 0.1827 0.0129 2.24e-45 'Protein S100-A16 ENSG00000188643 'S100A16 intron_variant ENSG00000188643 ENSG00000188643|ENSG00000189334 'S100A14|S100A16 3 novel suggestive_specific_pathway S100A16 chr1 153606886 153613145 -1 140576 protein_coding 1:153624127 10982 25_4_4 SeqId_10561_5 'PGRP-I-alpha chr1:153315579_A_G$SeqId_10561_5 1 chr1:153315579_A_G rs3014863 cis 1 153315579 A G 0.0859 0.1738 0.024 4.91e-13 'Peptidoglycan recognition protein 3 ENSG00000159527 'PGLYRP3 synonymous_variant ENSG00000159527 ENSG00000159527 'PGLYRP3 3 known specific_pathway PGLYRP3 chr1 153297116 153312952 -1 114771 protein_coding 1:153343103 30151 25_4_5 SeqId_5852_6 'S100A12 chr1:153337943_A_G$SeqId_5852_6 1 chr1:153337943_A_G rs3014874 cis 1 153337943 A G 0.2643 -0.2694 0.015 1.69e-72 'Protein S100-A12 ENSG00000163221 'S100A12 downstream_gene_variant ENSG00000163221 ENSG00000163221 'S100A12 3 known suggestive_specific_pathway S100A12 chr1 153373711 153375621 -1 6283 protein_coding 1:153365467 10154 25_4_6 SeqId_7916_10 'S100A7 chr1:153431406_C_G$SeqId_7916_10 1 chr1:153431406_C_G rs3014837 cis 1 153431406 C G 0.0566 1.7303 0.0246 5.64e-1077 'Protein S100-A7 ENSG00000143556 'S100A7 missense_variant ENSG00000143556 ENSG00000143556 'S100A7 3 known suggestive_specific_pathway S100A7 chr1 153457744 153460651 -1 6278 protein_coding 1:153458930 1721 25_4_7 SeqId_11969_5 'S100A2 chr1:153526349_G_T$SeqId_11969_5 1 chr1:153526349_G_T rs55955983 cis 1 153526349 T G 0.9502 0.3348 0.0303 2.55e-28 'Protein S100-A2 ENSG00000196754 'S100A2 upstream_gene_variant 0.962816 rs1047325 ENSG00000196754 'S100A2 missense_variant ENSG00000196754 ENSG00000196754 'S100A2 3 known specific_protein S100A2 chr1 153561108 153567890 -1 6273 protein_coding 1:153553873 14017 25_4_8 SeqId_11308_8 'CR3L4 chr1:153940144_D_I$SeqId_11308_8 1 chr1:153940144_D_I rs11288257 cis 1 153940144 D I 0.4778 0.3102 0.0131 1.94e-123 'Cyclic AMP-responsive element-binding protein 3-like protein 4 ENSG00000143578 'CREB3L4 upstream_gene_variant 0.463043 rs11264743 ENSG00000143578 'CREB3L4 missense_variant ENSG00000143578 ENSG00000143578 'CREB3L4 3 known specific_protein CREB3L4 chr1 153967534 153974361 1 148327 protein_coding 1:153967669 135 25_5_2 SeqId_12450_42 'PMVK chr1:154900134_A_G$SeqId_12450_42 1 chr1:154900134_A_G rs56720968 cis 1 154900134 A G 0.0645 -0.2011 0.0256 3.58e-15 'Phosphomevalonate kinase ENSG00000163344 'PMVK intron_variant ENSG00000163344 ENSG00000163344 'PMVK 3 novel specific_protein PMVK chr1 154924740 154936719 -1 10654 protein_coding 1:154927658 9061 25_5_4 SeqId_15607_56 'KPYR chr1:155271433_D_I$SeqId_15607_56 1 chr1:155271433_D_I rs141119689 cis 1 155271433 D I 0.0679 -0.1996 0.0275 3.78e-13 'Pyruvate kinase PKLR ENSG00000143627 'PKLR upstream_gene_variant ENSG00000143627 ENSG00000143627 'PKLR 3 known unspecific_effect PKLR chr1 155289293 155301438 -1 5313 protein_coding 1:155301643 205 25_5_5 SeqId_7089_42 'SYT11 chr1:155816085_A_G$SeqId_7089_42 1 chr1:155816085_A_G rs145976521 cis 1 155816085 A G 0.1103 -0.2504 0.0213 7.26e-32 'Synaptotagmin-11 ENSG00000132718 'SYT11 intron_variant ENSG00000132718 ENSG00000132718 'SYT11 3 known specific_protein SYT11 chr1 155859567 155885199 1 23208 protein_coding 1:155846294 13273 25_5_6 SeqId_16915_153 'SEM4A chr1:156149265_C_T$SeqId_16915_153 1 chr1:156149265_C_T rs372266718 cis 1 156149265 T C 0.6066 -0.1778 0.0138 3.82e-38 'Semaphorin-4A ENSG00000196189 'SEMA4A downstream_gene_variant ENSG00000196189 ENSG00000196189 'SEMA4A 3 novel specific_protein SEMA4A chr1 156147366 156177752 1 64218 protein_coding 1:156179474 32108 25_6_10 SeqId_8973_23 'FCRL4 chr1:157559122_C_T$SeqId_8973_23 1 chr1:157559122_C_T rs11582663 cis 1 157559122 T C 0.1518 -1.0827 0.0154 5.43e-1076 'Fc receptor-like protein 4 ENSG00000163518 'FCRL4 missense_variant ENSG00000163518 ENSG00000163518 'FCRL4 3 known suggestive_specific_pathway FCRL4 chr1 157573747 157598085 -1 83417 protein_coding 1:157589332 8753 25_6_11 SeqId_4440_15 'FCRL3 chr1:157668390_C_T$SeqId_4440_15 1 chr1:157668390_C_T rs7522061 cis 1 157668390 T C 0.5223 -0.8073 0.0112 6.90e-1131 'Fc receptor-like protein 3 ENSG00000160856 'FCRL3 missense_variant ENSG00000160856 ENSG00000160856 'FCRL3 3 known suggestive_specific_pathway -0.80023 0.049681 4.74241985260247e-47 yes FCRL3 Olink IMMUNE RESPONSE(v.3202) FCRL3 chr1 157674321 157700769 -1 115352 protein_coding 1:157698600 2169 25_6_12 SeqId_5728_60 'FCRL1 chr1:157771880_C_T$SeqId_5728_60 1 chr1:157771880_C_T rs4971154 cis 1 157771880 T C 0.506 -0.346 0.0126 2.64e-165 'Fc receptor-like protein 1 ENSG00000163534 'FCRL1 synonymous_variant ENSG00000163534 ENSG00000163534 'FCRL1 3 known suggestive_specific_pathway -0.39664 0.060036 1.03968074292752e-10 yes FCRL1 Olink METABOLISM(v.3402) FCRL1 chr1 157794403 157820120 -1 115350 protein_coding 1:157802090 18030 25_6_13 SeqId_3293_2 'CD5L chr1:157804648_A_G$SeqId_3293_2 1 chr1:157804648_A_G rs2765501 cis 1 157804648 A G 0.4057 0.3734 0.0136 1.69e-166 'CD5 antigen-like ENSG00000073754 'CD5L intron_variant ENSG00000073754 ENSG00000073754 'CD5L 3 known suggestive_specific_pathway CD5L chr1 157830911 157898256 -1 922 protein_coding 1:157834858 63398 25_6_2 SeqId_16758_96 'HDGF chr1:156700651_G_T$SeqId_16758_96 1 chr1:156700651_G_T rs12145743 cis 1 156700651 T G 0.6583 0.11 0.0127 5.69e-18 'Hepatoma-derived growth factor ENSG00000143321 'HDGF intron_variant 0.990141 rs4399146 ENSG00000143321 'HDGF missense_variant ENSG00000143321 ENSG00000143321 'HDGF 7 known suggestive_specific_pathway HDGF chr1 156742109 156766925 -1 3068 protein_coding 1:156730859 36066 25_6_2 SeqId_8953_47 'HDGF chr1:156685732_A_C$SeqId_8953_47 1 chr1:156685732_A_C rs12121617 cis 1 156685732 A C 0.3339 -0.0908 0.0133 9.97e-12 'Hepatoma-derived growth factor ENSG00000143321 'HDGF upstream_gene_variant 0.913308 rs4399146 ENSG00000143321 'HDGF missense_variant ENSG00000143321 ENSG00000143321 'HDGF 7 known suggestive_specific_pathway HDGF chr1 156742109 156766925 -1 3068 protein_coding 1:156715940 50985 25_6_4 SeqId_16621_77 'AIBP chr1:156563726_A_C$SeqId_16621_77 1 chr1:156563726_A_C rs6427322 cis 1 156563726 A C 0.0314 -0.623 0.0346 1.37e-72 'NAD(P)H-hydrate epimerase ENSG00000163382 'APOA1BP synonymous_variant 0.988329 rs7516274 ENSG00000163382 'APOA1BP missense_variant ENSG00000163382 ENSG00000163382 'NAXE 3 novel specific_protein NAXE chr1 156591756 156609507 1 128240 protein_coding 1:156593934 2178 25_6_5 SeqId_3461_58 'PGCB chr1:156615114_A_G$SeqId_3461_58 1 chr1:156615114_A_G rs2365715 cis 1 156615114 A G 0.6104 0.2064 0.0146 3.02e-45 'Brevican core protein ENSG00000132692 'BCAN intron_variant 0.203728 rs1056695 ENSG00000132692 'BCAN missense_variant ENSG00000132692 ENSG00000132692 'BCAN 3 known specific_protein 0.17915 0.066158 0.00701132340686737 yes BCAN Olink NEUROLOGY(v.8011) BCAN chr1 156641390 156659532 1 63827 protein_coding 1:156645322 3932 25_6_6 SeqId_11696_7 'RABP2 chr1:156676553_G_T$SeqId_11696_7 1 chr1:156676553_G_T rs3806412 cis 1 156676553 T G 0.6072 0.3102 0.0134 9.18e-119 'Cellular retinoic acid-binding protein 2 ENSG00000143320 'CRABP2 upstream_gene_variant ENSG00000143320 ENSG00000143320 'CRABP2 3 novel specific_protein CRABP2 chr1 156699606 156705816 -1 1382 protein_coding 1:156706761 945 25_6_7 SeqId_8892_14 'PEAR1 chr1:156869714_A_G$SeqId_8892_14 1 chr1:156869714_A_G rs12041331 cis 1 156869714 A G 0.0858 -0.1608 0.0227 1.31e-12 'Platelet endothelial aggregation receptor 1 ENSG00000187800 'PEAR1 intron_variant ENSG00000187800 ENSG00000187800 'PEAR1 3 known unspecific_effect PEAR1 chr1 156893698 156916429 1 375033 protein_coding 1:156899922 6224 25_6_9 SeqId_8275_31 'PEAR1 chr1:156885491_G_T$SeqId_8275_31 1 chr1:156885491_G_T rs4661012 cis 1 156885491 T G 0.6432 0.2799 0.0134 3.8e-97 'Platelet endothelial aggregation receptor 1 ENSG00000187800 'PEAR1 3_prime_UTR_variant 0.521981 rs12137505 ENSG00000187800 'PEAR1 missense_variant ENSG00000187800 ENSG00000187800 'PEAR1 3 known suggestive_specific_pathway 0.11367 0.065287 0.0823000312277345 no PEAR1 Olink DEVELOPMENT(v.3511) PEAR1 chr1 156893698 156916429 1 375033 protein_coding 1:156915699 22001 25_7_2 SeqId_11636_33 'Transgelin-2 chr1:159892088_A_G$SeqId_11636_33 1 chr1:159892088_A_G rs2789422 cis 1 159892088 A G 0.4239 -0.1413 0.0136 1.9e-25 'Transgelin-2 ENSG00000158710 'TAGLN2 intron_variant ENSG00000158710 ENSG00000158710 'TAGLN2 3 novel unspecific_effect TAGLN2 chr1 159918107 159925507 -1 8407 protein_coding 1:159922298 3209 25_7_2 SeqId_9201_13 'Transgelin-2 chr1:159892088_A_G$SeqId_9201_13 1 chr1:159892088_A_G rs2789422 cis 1 159892088 A G 0.424 -0.1059 0.0132 8.66e-16 'Transgelin-2 ENSG00000158710 'TAGLN2 intron_variant ENSG00000158710 ENSG00000158710 'TAGLN2 3 novel unspecific_effect TAGLN2 chr1 159918107 159925507 -1 8407 protein_coding 1:159922298 3209 25_7_4 SeqId_2474_54 'SAP chr1:159566207_D_I$SeqId_2474_54 1 chr1:159566207_D_I rs35737842 cis 1 159566207 D I 0.0235 -0.6632 0.04 1.15e-61 'Serum amyloid P-component ENSG00000132703 'APCS upstream_gene_variant ENSG00000132703 ENSG00000132703 'APCS 3 known specific_protein APCS chr1 159587826 159588865 1 325 protein_coding 1:159596418 8592 25_7_5 SeqId_4337_49 'CRP chr1:159699249_G_T$SeqId_4337_49 1 chr1:159699249_G_T rs4546916 cis 1 159699249 T G 0.3252 -0.1783 0.0143 1.81e-35 'C-reactive protein ENSG00000132693 'CRP intergenic_variant ENSG00000132693 ENSG00000132693 'CRP 3 known specific_protein CRP chr1 159712289 159714589 -1 1401 protein_coding 1:159729459 14870 25_7_6 SeqId_6617_12 'FCRL6 chr1:159782549_C_G$SeqId_6617_12 1 chr1:159782549_C_G rs6657365 cis 1 159782549 C G 0.8053 0.2186 0.0168 1.68e-38 'Fc receptor-like protein 6 ENSG00000181036 'FCRL6 intron_variant 0.668176 rs61823162 ENSG00000181036 'FCRL6 stop_gained ENSG00000181036 ENSG00000181036 'FCRL6 3 known specific_protein FCRL6 chr1 159800511 159816257 1 343413 protein_coding 1:159812759 12248 25_8_12 SeqId_3309_2 'FCG2A chr1:161478859_C_T$SeqId_3309_2 1 chr1:161478859_C_T rs4657041 cis 1 161478859 T C 0.4827 -1.2187 0.0071 7.22e-6401 'Low affinity immunoglobulin gamma Fc region receptor II-a ENSG00000143226 'FCGR2A intron_variant 0.150759 rs9427397 ENSG00000143226 'FCGR2A stop_gained ENSG00000143226 ENSG00000143226 'FCGR2A 3 known specific_pathway -0.26049 0.062587 3.73422085430342e-05 yes FCGR2A Olink CARDIOMETABOLIC(v.3602) FCGR2A chr1 161505430 161524013 1 2212 protein_coding 1:161509069 3639 25_8_14 SeqId_3310_62 'FCG2B chr1:161641384_A_G$SeqId_3310_62 1 chr1:161641384_A_G 1:161641384_G_A cis 1 161641384 A G 0.195 1.3415 0.0122 2.17e-2628 'Low affinity immunoglobulin gamma Fc region receptor II-b ENSG00000072694 'FCGR2B synonymous_variant ENSG00000072694 ENSG00000072694 'FCGR2B 3 known unspecific_effect 0.99947 0.070699 3.40408189700998e-38 yes IgG Fc receptor II-b Olink CARDIOVASCULAR II(v.5004) FCGR2B chr1 161663143 161678654 1 2213 protein_coding 1:161671594 8451 25_8_16 SeqId_15583_18 'FCRLB chr1:161688739_C_T$SeqId_15583_18 1 chr1:161688739_C_T rs12045955 cis 1 161688739 T C 0.9407 -0.7464 0.0277 1.25e-159 'Fc receptor-like B ENSG00000162746 'FCRLB upstream_gene_variant ENSG00000162746 ENSG00000162746 'FCRLB 3 novel unspecific_effect -1.451 0.10208 1.50660706618673e-38 yes FCRLB Olink ONCOLOGY II(v.7002) FCRLB chr1 161721563 161728143 1 127943 protein_coding 1:161718949 2614 25_8_2 SeqId_3311_27 'FCG3B chr1:161507924_A_G$SeqId_3311_27 1 chr1:161507924_A_G rs10800573 cis 1 161507924 A G 0.6684 -0.4875 0.0143 2.19e-256 'Low affinity immunoglobulin gamma Fc region receptor III-B ENSG00000162747 'FCGR3B downstream_gene_variant 0.159403 rs10127939_A_T ENSG00000203747 'FCGR3A missense_variant ENSG00000162747 ENSG00000162747|ENSG00000203747 'FCGR3A|FCGR3B 3 known specific_pathway -0.11973 0.065857 0.0696626514110769 no FCGR3B Olink CARDIOMETABOLIC(v.3602) FCGR3B chr1 161623196 161631963 -1 2215 protein_coding 1:161538134 93829 25_8_2 SeqId_15388_24 'FcRIIIa chr1:161507924_A_G$SeqId_15388_24 1 chr1:161507924_A_G rs10800573 cis 1 161507924 A G 0.6688 -1.2441 0.0086 2.70e-4547 'Low affinity immunoglobulin gamma Fc region receptor III-A ENSG00000203747 'FCGR3A downstream_gene_variant 0.159403 rs10127939_A_T ENSG00000203747 'FCGR3A missense_variant ENSG00000203747 ENSG00000162747|ENSG00000203747 'FCGR3A|FCGR3B 3 known specific_pathway FCGR3A chr1 161541759 161550737 -1 2214 protein_coding 1:161538134 12603 25_8_3 SeqId_6984_6 'IGSF8 chr1:160062727_A_G$SeqId_6984_6 1 chr1:160062727_A_G rs2295621 cis 1 160062727 A G 0.7868 -0.1927 0.0162 1.65e-32 'Immunoglobulin superfamily member 8 ENSG00000162729 'IGSF8 synonymous_variant ENSG00000162729 ENSG00000162729 'IGSF8 3 novel specific_protein IGSF8 chr1 160091340 160098943 -1 93185 protein_coding 1:160092937 6006 25_8_4 SeqId_5128_53 'SLAF6 chr1:160460099_A_T$SeqId_5128_53 1 chr1:160460099_A_T rs11265413 cis 1 160460099 A T 0.2073 -0.3572 0.016 4.48e-110 'SLAM family member 6 ENSG00000162739 'SLAMF6 intron_variant ENSG00000162739 ENSG00000162739 'SLAMF6 3 known specific_protein SLAMF6 chr1 160485030 160523262 -1 114836 protein_coding 1:160490309 32953 25_8_5 SeqId_3292_75 'CD48 chr1:160654786_A_G$SeqId_3292_75 1 chr1:160654786_A_G rs1980606 cis 1 160654786 A G 0.2092 -0.2384 0.0159 1.59e-50 'CD48 antigen ENSG00000117091 'CD48 synonymous_variant 0.612306 rs2295615 ENSG00000117091 'CD48 missense_variant ENSG00000117091 ENSG00000117091 'CD48 3 known specific_protein -0.69078 0.072273 6.1517687270987e-20 yes CD48 Olink ONCOLOGY II(v.7002) CD48 chr1 160678746 160711831 -1 962 protein_coding 1:160684996 26835 25_8_6 SeqId_5487_7 'SLAF7 chr1:160720074_C_T$SeqId_5487_7 1 chr1:160720074_C_T rs11581248 cis 1 160720074 T C 0.1293 -1.2978 0.0164 1.52e-1362 'SLAM family member 7 ENSG00000026751 'SLAMF7 intron_variant ENSG00000026751 ENSG00000026751 'SLAMF7 3 known specific_protein -0.8579 0.094269 2.39331575640539e-18 yes SLAMF7 Olink CARDIOVASCULAR II(v.5004) SLAMF7 chr1 160739057 160754821 1 57823 protein_coding 1:160750284 11227 25_8_7 SeqId_3324_51 'LY9 chr1:160762784_G_T$SeqId_3324_51 1 chr1:160762784_G_T rs12128261 cis 1 160762784 T G 0.7856 -0.4098 0.0151 3.01e-161 'T-lymphocyte surface antigen Ly-9 ENSG00000122224 'LY9 upstream_gene_variant 0.334201 rs509749 ENSG00000122224 'LY9 missense_variant ENSG00000122224 ENSG00000122224 'LY9 3 known suggestive_specific_pathway -0.65605 0.075915 8.20351544329821e-17 yes LY9 Olink ONCOLOGY II(v.7002) LY9 chr1 160796074 160828261 1 4063 protein_coding 1:160792994 3080 25_8_8 SeqId_18830_1 'Omentin chr1:160851534_A_G$SeqId_18830_1 1 chr1:160851534_A_G rs7532133 cis 1 160851534 A G 0.3196 0.1516 0.0136 1.04e-28 'Intelectin-1 ENSG00000179914 'ITLN1 intron_variant 0.99158 rs2274907 ENSG00000179914 'ITLN1 missense_variant ENSG00000179914 ENSG00000179914 'ITLN1 3 known unspecific_effect ITLN1 chr1 160876540 160885180 -1 55600 protein_coding 1:160881744 3436 25_8_9 SeqId_19277_4 'KAT chr1:161008535_C_G$SeqId_19277_4 1 chr1:161008535_C_G rs10908821 cis 1 161008535 C G 0.8733 -0.6849 0.0175 5.03e-335 'Thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 1 ENSG00000215845 'TSTD1 intron_variant ENSG00000215845 ENSG00000215845 'TSTD1 3 novel specific_protein TSTD1 chr1 161037631 161038977 -1 100131187 protein_coding 1:161038745 232 25_9_1 SeqId_8272_22 'DHB7 chr1:162767200_D_I$SeqId_8272_22 1 chr1:162767200_D_I rs35057012 cis 1 162767200 D I 0.2167 0.1869 0.0172 1.25e-27 '3-keto-steroid reductase ENSG00000132196 'HSD17B7 intron_variant ENSG00000132196 ENSG00000132196 'HSD17B7 3 novel specific_protein HSD17B7 chr1 162790702 162812823 1 51478 protein_coding 1:162797411 6709 250_1_1 SeqId_14066_49 'MAGI2 chr7:79065927_A_C$SeqId_14066_49 1 chr7:79065927_A_C rs73147474 cis 7 79065927 A C 0.8464 -0.9101 0.0162 6.57e-688 'Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 ENSG00000187391 'MAGI2 intron_variant ENSG00000187391 ENSG00000187391 'MAGI2 3 novel specific_protein MAGI2 chr7 78017055 79453667 -1 9863 protein_coding 7:79436611 17056 250_2_1 SeqId_2973_15 'CD36 ANTIGEN chr7:80218961_C_T$SeqId_2973_15 1 chr7:80218961_C_T rs6961069 cis 7 80218961 T C 0.4069 0.2893 0.0135 2.11e-101 'Platelet glycoprotein 4 ENSG00000135218 'CD36 intron_variant ENSG00000135218 ENSG00000135218 'CD36 3 known specific_protein CD36 chr7 80369575 80679277 1 948 protein_coding 7:80589645 220070 250_2_2 SeqId_6448_36 'Sema E chr7:80583482_A_G$SeqId_6448_36 1 chr7:80583482_A_G rs7783868 cis 7 80583482 A G 0.5642 0.1426 0.0134 1.71e-26 'Semaphorin-3C ENSG00000075223 'SEMA3C regulatory_region_variant ENSG00000075223 ENSG00000075223 'SEMA3C 3 known specific_protein SEMA3C chr7 80742538 80922359 -1 10512 protein_coding 7:80954166 31807 250_2_3 SeqId_2681_23 'HGF chr7:81358338_D_I$SeqId_2681_23 1 chr7:81358338_D_I rs554133413 cis 7 81358338 D I 0.2426 -0.1936 0.0157 9.31e-35 'Hepatocyte growth factor ENSG00000019991 'HGF intron_variant ENSG00000019991 ENSG00000019991 'HGF 3 known specific_protein -0.11478 0.072631 0.114699097313576 no HGF Olink INFLAMMATION(v.3012) HGF chr7 81699010 81770438 -1 3082 protein_coding 7:81729023 41415 250_3_1 SeqId_5363_51 'Semaphorin 3E chr7:83022451_A_G$SeqId_5363_51 1 chr7:83022451_A_G rs56921187 cis 7 83022451 A G 0.1205 -1.1337 0.0174 1.80e-924 'Semaphorin-3E ENSG00000170381 'SEMA3E intron_variant 0.992128 rs61729612 ENSG00000170381 'SEMA3E missense_variant ENSG00000170381 ENSG00000170381 'SEMA3E 3 known specific_protein SEMA3E chr7 83363238 83649139 -1 9723 protein_coding 7:83393135 256004 251_1_1 SeqId_13929_27 'OCTC chr7:87032613_A_G$SeqId_13929_27 1 chr7:87032613_A_G rs31653 cis 7 87032613 A G 0.1076 -0.7618 0.0194 2.96e-337 'Peroxisomal carnitine O-octanoyltransferase ENSG00000005469 'CROT intron_variant ENSG00000005469 ENSG00000005469 'CROT 3 novel specific_protein CROT chr7 87345664 87399794 1 54677 protein_coding 7:87403297 57633 251_1_2 SeqId_7933_75 'ADA22 chr7:87564497_C_G$SeqId_7933_75 1 chr7:87564497_C_G rs2279542 cis 7 87564497 C G 0.4936 0.2308 0.013 3.52e-70 'Disintegrin and metalloproteinase domain-containing protein 22 ENSG00000008277 'ADAM22 missense_variant ENSG00000008277 ENSG00000008277 'ADAM22 3 known specific_protein 0.54812 0.059114 6.19441075076784e-19 yes ADAM 22 Olink NEUROLOGY(v.8011) ADAM22 chr7 87934143 88202889 1 53616 protein_coding 7:87935182 1039 251_2_1 SeqId_12356_65 'Sorcin chr7:87864495_A_G$SeqId_12356_65 1 chr7:87864495_A_G rs77010538 cis 7 87864495 A G 0.2049 0.2032 0.0162 2.7e-36 'Sorcin ENSG00000075142 'SRI intron_variant,non_coding_transcript_variant ENSG00000075142 ENSG00000075142 'SRI 3 novel specific_protein SRI chr7 88205115 88226993 -1 6717 protein_coding 7:88235180 8187 252_1_3 SeqId_12895_28 'DGKB chr7:94934200_A_G$SeqId_12895_28 1 chr7:94934200_A_G rs2237582 trans 7 94934200 A G 0.706 -0.0969 0.0139 3.52e-12 'Diacylglycerol kinase beta ENSG00000136267 'DGKB intron_variant 0.99729 rs662 ENSG00000005421 'PON1 missense_variant ENSG00000005421 ENSG00000005421 'PON1 4 known unspecific_effect DGKB chr7 14145049 14974777 -1 1607 protein_coding 7:95304888 80330111 253_1_1 SeqId_9337_43 'TKN1 chr7:97366332_A_G$SeqId_9337_43 1 chr7:97366332_A_G rs78145257 cis 7 97366332 A G 0.1705 -0.2893 0.0178 3.98e-59 'Protachykinin-1 ENSG00000006128 'TAC1 intron_variant ENSG00000006128 ENSG00000006128 'TAC1 3 known specific_protein TAC1 chr7 97732084 97740472 1 6863 protein_coding 7:97737020 4936 253_1_3 SeqId_6521_35 'NPTX2 chr7:98286099_A_C$SeqId_6521_35 1 chr7:98286099_A_C rs11773439 cis 7 98286099 A C 0.7167 0.1945 0.0142 1.02e-42 'Neuronal pentraxin-2 ENSG00000106236 'NPTX2 intergenic_variant ENSG00000106236 ENSG00000106236 'NPTX2 3 known specific_protein NPTX2 chr7 98617285 98629869 1 4885 protein_coding 7:98656787 39502 253_2_1 SeqId_12689_56 'ARC1B chr7:98995724_A_G$SeqId_12689_56 1 chr7:98995724_A_G rs75944999 cis 7 98995724 A G 0.0413 0.2837 0.0336 3.04e-17 'Actin-related protein 2/3 complex subunit 1B ENSG00000130429 'ARPC1B intron_variant 0.98993 rs1045012 ENSG00000130429 'ARPC1B missense_variant ENSG00000130429 ENSG00000130429 'ARPC1B 3 novel specific_protein ARPC1B chr7 99374249 99394816 1 10095 protein_coding 7:99398101 23852 253_2_3 SeqId_9312_8 'AZGP1 chr7:99537653_A_G$SeqId_9312_8 1 chr7:99537653_A_G rs2527896 cis 7 99537653 A G 0.7135 0.3875 0.0141 1.91e-165 'Zinc-alpha-2-glycoprotein ENSG00000160862 'AZGP1 intron_variant ENSG00000160862 ENSG00000160862 'AZGP1 3 known unspecific_effect AZGP1 chr7 99966720 99976042 -1 563 protein_coding 7:99940030 36012 253_2_6 SeqId_10816_150 'PILRA isoform FDF03-M14 chr7:99971313_C_T$SeqId_10816_150 1 chr7:99971313_C_T rs2405442 cis 7 99971313 T C 0.3175 1.2669 0.0081 3.75e-5315 'Paired immunoglobulin-like type 2 receptor alpha isoform FDF03-M14 ENSG00000085514 'PILRA synonymous_variant 0.996925 rs1859788 ENSG00000085514 'PILRA missense_variant ENSG00000085514 ENSG00000085514 'PILRA 3 known unspecific_effect -0.74251 0.062185 5.5462571295791e-29 no PILRA Olink DEVELOPMENT(v.3511) PILRA chr7 100367530 100400096 1 29992 protein_coding 7:100373690 6160 253_2_6 SeqId_6402_8 'PILRA isoform FDF03-deltaTM chr7:99971834_A_G$SeqId_6402_8 1 chr7:99971834_A_G rs1859788 cis 7 99971834 A G 0.3177 1.2588 0.0081 1.94e-5247 'Paired immunoglobulin-like type 2 receptor alpha isoform FDF03-deltaTM ENSG00000085514 'PILRA missense_variant ENSG00000085514 ENSG00000085514 'PILRA 3 known unspecific_effect -0.74009 0.061724 3.48337315036013e-29 no PILRA Olink DEVELOPMENT(v.3511) PILRA chr7 100367530 100400096 1 29992 protein_coding 7:100374211 6681 253_3_1 SeqId_11237_49 'PCOC1 chr7:100235970_A_C$SeqId_11237_49 1 chr7:100235970_A_C rs7385804 cis 7 100235970 A C 0.6197 0.2275 0.0135 5.89e-64 'Procollagen C-endopeptidase enhancer 1 ENSG00000106333 'PCOLCE intron_variant 0.286256 rs2293767 ENSG00000146839 'ZAN missense_variant ENSG00000106333 ENSG00000106333 'PCOLCE 3 known unspecific_effect 0.21956 0.061338 0.000378878533748437 yes PCOLCE Olink CARDIOMETABOLIC(v.3602) PCOLCE chr7 100602363 100608175 1 5118 protein_coding 7:100638347 35984 253_3_4 SeqId_2925_9 'PAI-1 chr7:100769538_A_G$SeqId_2925_9 1 chr7:100769538_A_G rs2227631 cis 7 100769538 A G 0.5867 0.1032 0.0132 6.44e-15 'Plasminogen activator inhibitor 1 ENSG00000106366 'SERPINE1 upstream_gene_variant 0.17332 rs6092 ENSG00000106366 'SERPINE1 missense_variant ENSG00000106366 ENSG00000106366 'SERPINE1 3 known specific_pathway 0.12213 0.061765 0.0485847530937493 yes PAI Olink CARDIOVASCULAR III(v.6112) SERPINE1 chr7 101127104 101139247 1 5054 protein_coding 7:101126257 847 253_3_5 SeqId_17746_77 'FIS1 chr7:100882477_A_G$SeqId_17746_77 1 chr7:100882477_A_G rs79067051 cis 7 100882477 A G 0.0549 -0.5144 0.0269 2.89e-81 'Mitochondrial fission 1 protein ENSG00000214253 'FIS1 upstream_gene_variant ENSG00000214253 ENSG00000214253 'FIS1 3 known specific_protein FIS1 chr7 101239458 101252316 -1 51024 protein_coding 7:101239196 13120 254_1_1 SeqId_14066_49 'MAGI2 chr7:106372219_C_G$SeqId_14066_49 1 chr7:106372219_C_G rs342293 trans 7 106372219 C G 0.5399 0.1056 0.0135 4.75e-15 'Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 ENSG00000187391 'MAGI2 intron_variant ENSG00000243797|ENSG00000105851|ENSG00000105856|ENSG00000283847 ENSG00000005249|ENSG00000075790|ENSG00000105835|ENSG00000105851|ENSG00000105856|ENSG00000243797|ENSG00000283847|ENSG00000284096|ENSG00000288558 'BCAP29|DUS4L-BCAP29|HBP1|HBP1|NAMPT|PIK3CG|PRKAR2B|PRKAR2B 1 known unspecific_effect MAGI2 chr7 78017055 79453667 -1 9863 protein_coding 7:106731773 27278106 255_1_1 SeqId_15527_90 'DLDH chr7:107495434_A_G$SeqId_15527_90 1 chr7:107495434_A_G rs886774 cis 7 107495434 A G 0.5835 0.0945 0.0136 3.69e-12 'Dihydrolipoyl dehydrogenase, mitochondrial ENSG00000091140 'DLD intergenic_variant ENSG00000091140 ENSG00000091140 'DLD 3 novel specific_protein DLD chr7 107891162 107931730 1 1738 protein_coding 7:107854989 36173 256_1_1 SeqId_17419_17 'TES chr7:115851487_C_T$SeqId_17419_17 1 chr7:115851487_C_T rs13223583 cis 7 115851487 T C 0.4292 -0.1309 0.0128 1.98e-24 'Testin ENSG00000135269 'TES intron_variant ENSG00000135269 ENSG00000135269 'TES 3 novel specific_protein TES chr7 116210506 116258783 1 26136 protein_coding 7:116211433 927 256_1_2 SeqId_2837_3 'Met chr7:116296896_C_T$SeqId_2837_3 1 chr7:116296896_C_T rs437 cis 7 116296896 T C 0.7161 -0.1256 0.015 6.87e-17 'Hepatocyte growth factor receptor ENSG00000105976 'MET intergenic_variant ENSG00000105976 ENSG00000105976 'MET 3 known specific_protein -0.22322 0.067447 0.00100392206590703 yes MET Olink CARDIOMETABOLIC(v.3602) MET chr7 116672196 116798377 1 4233 protein_coding 7:116656842 15354 258_1_2 SeqId_9267_2 'CBPA4 chr7:129938598_G_T$SeqId_9267_2 1 chr7:129938598_G_T rs34587586 cis 7 129938598 T G 0.4003 -1.1373 0.0086 1.57e-3800 'Carboxypeptidase A4 ENSG00000128510 'CPA4 missense_variant ENSG00000128510 ENSG00000128510 'CPA4 3 known specific_protein CPA4 chr7 130293134 130324180 1 51200 protein_coding 7:130298758 5624 259_1_1 SeqId_19560_23 'PLXA4 chr7:132238011_G_T$SeqId_19560_23 1 chr7:132238011_G_T rs6467443 cis 7 132238011 T G 0.2187 0.1487 0.016 1.63e-20 'Plexin-A4 ENSG00000221866 'PLXNA4 intron_variant ENSG00000221866 ENSG00000221866 'PLXNA4 3 novel specific_protein PLXNA4 chr7 132123340 132648688 -1 91584 protein_coding 7:132553252 95436 26_1_1 SeqId_9357_4 'CREG1 chr1:167513418_C_T$SeqId_9357_4 1 chr1:167513418_C_T rs1229430 cis 1 167513418 T C 0.5993 -0.244 0.0136 1.41e-71 'Protein CREG1 ENSG00000143162 'CREG1 intron_variant ENSG00000143162 ENSG00000143162 'CREG1 3 known specific_protein CREG1 chr1 167529117 167553805 -1 8804 protein_coding 1:167544181 9624 26_1_2 SeqId_15617_8 'lymphotactin beta chr1:168514008_C_T$SeqId_15617_8 1 chr1:168514008_C_T rs10753774 cis 1 168514008 T C 0.2987 0.1019 0.0141 5.25e-13 'Cytokine SCM-1 beta ENSG00000143185 'XCL2 upstream_gene_variant ENSG00000143185 ENSG00000143185 'XCL2 3 known specific_protein XCL2 chr1 168540768 168543997 -1 6846 protein_coding 1:168544770 773 26_1_3 SeqId_4979_34 'DERM chr1:168697761_A_C$SeqId_4979_34 1 chr1:168697761_A_C rs1018454 cis 1 168697761 A C 0.4195 -0.398 0.0128 8.49e-211 'Dermatopontin ENSG00000143196 'DPT intron_variant ENSG00000143196 ENSG00000143196 'DPT 3 known specific_protein DPT chr1 168695468 168729206 -1 1805 protein_coding 1:168728523 683 26_2_1 SeqId_16926_44 'Alkaline phosphatase, liver chr1:169474397_C_T$SeqId_16926_44 1 chr1:169474397_C_T rs61808983 trans 1 169474397 T C 0.0493 0.3668 0.033 1.18e-28 'Alkaline phosphatase, tissue-nonspecific isozyme ENSG00000162551 'ALPL intergenic_variant 1.0 rs9332701 ENSG00000198734 'F5 missense_variant ENSG00000198734 ENSG00000198734 'F5 6 known unspecific_effect ALPL chr1 21509397 21578410 1 249 protein_coding 1:169505159 147995762 26_2_1 SeqId_4906_35 'Coagulation Factor V chr1:169484767_A_G$SeqId_4906_35 1 chr1:169484767_A_G rs9332701 cis 1 169484767 A G 0.9508 0.6681 0.0336 7.94e-88 'Coagulation Factor V ENSG00000198734 'F5 missense_variant ENSG00000198734 ENSG00000198734 'F5 6 known unspecific_effect F5 chr1 169511951 169586588 -1 2153 protein_coding 1:169515529 71059 26_2_3 SeqId_13236_25 'WNT3A chr1:169494501_A_G$SeqId_13236_25 1 chr1:169494501_A_G rs2301519 trans 1 169494501 A G 0.0557 -0.5263 0.0292 1.88e-72 'Protein Wnt-3a ENSG00000154342 'WNT3A intron_variant 0.994659 rs6027 ENSG00000198734 'F5 missense_variant ENSG00000198734 ENSG00000198734 'F5 4 known unspecific_effect WNT3A chr1 228006998 228061271 1 89780 protein_coding 1:169525263 58481735 26_2_3 SeqId_18925_24 'Proteasome subunit alpha type 5 chr1:169482678_A_G$SeqId_18925_24 1 chr1:169482678_A_G rs9332673 trans 1 169482678 A G 0.0558 -0.4342 0.028 3.76e-54 'Proteasome subunit alpha type-5 ENSG00000143106 'PSMA5 downstream_gene_variant 0.996818 rs6027 ENSG00000198734 'F5 missense_variant ENSG00000198734 ENSG00000198734 'F5 4 known unspecific_effect PSMA5 chr1 109399042 109426448 -1 5686 protein_coding 1:169513440 60086992 26_2_3 SeqId_9039_47 'TOIP1 chr1:169483561_C_T$SeqId_9039_47 1 chr1:169483561_C_T rs6027 trans 1 169483561 T C 0.9442 0.6531 0.0287 2.87e-114 'Torsin-1A-interacting protein 1 ENSG00000143337 'TOR1AIP1 missense_variant ENSG00000198734 ENSG00000198734 'F5 4 known unspecific_effect TOR1AIP1 chr1 179882042 179920077 1 26092 protein_coding 1:169514323 10367719 26_2_4 SeqId_14603_51 'KIAA0040 chr1:169513436_A_C$SeqId_14603_51 1 chr1:169513436_A_C rs9287092 trans 1 169513436 A C 0.2457 0.139 0.0148 6.08e-21 'Uncharacterized protein KIAA0040 ENSG00000235750 'KIAA0040 intron_variant 0.854887 rs4525 ENSG00000198734 'F5 missense_variant ENSG00000198734 ENSG00000198734 'F5 4 known suggestive_specific_pathway KIAA0040 chr1 175156986 175192999 -1 9674 protein_coding 1:169544198 5648801 26_2_5 SeqId_4154_57 'P-Selectin chr1:169563951_G_T$SeqId_4154_57 1 chr1:169563951_G_T rs6136 cis 1 169563951 T G 0.8865 0.3017 0.0197 6.61e-53 'P-selectin ENSG00000174175 'SELP missense_variant ENSG00000174175 ENSG00000174175 'SELP 3 known unspecific_effect 0.14119 0.10047 0.160586857668976 no SELP Olink CARDIOVASCULAR III(v.6112) SELP chr1 169588849 169630193 -1 6403 protein_coding 1:169594713 35480 26_2_6 SeqId_4831_4 'sL-Selectin chr1:169666597_A_T$SeqId_4831_4 1 chr1:169666597_A_T rs4140655 cis 1 169666597 A T 0.7395 0.5546 0.0136 1.53e-363 'L-Selectin ENSG00000188404 'SELL intron_variant 0.810638 rs1131498 ENSG00000188404 'SELL missense_variant ENSG00000188404 ENSG00000188404 'SELL 3 known specific_protein 0.54452 0.06552 9.66050878989812e-16 yes SELL Olink CARDIOMETABOLIC(v.3602) SELL chr1 169690665 169711702 -1 6402 protein_coding 1:169697456 14246 26_2_7 SeqId_3470_1 'sE-Selectin chr1:169691439_A_G$SeqId_3470_1 1 chr1:169691439_A_G rs2205850 cis 1 169691439 A G 0.6515 -0.1264 0.0139 8.54e-20 'E-selectin ENSG00000007908 'SELE downstream_gene_variant ENSG00000007908 ENSG00000007908 'SELE 3 known suggestive_specific_pathway -0.123 0.062145 0.0483615264302044 yes SELE Olink CARDIOVASCULAR III(v.6112) SELE chr1 169722640 169764705 -1 6401 protein_coding 1:169722298 42407 26_3_3 SeqId_16558_2 'MYOC chr1:171617765_A_G$SeqId_16558_2 1 chr1:171617765_A_G rs7547721 cis 1 171617765 A G 0.0892 -0.6625 0.0221 9.99e-197 'Myocilin ENSG00000034971 'MYOC intron_variant ENSG00000034971 ENSG00000034971 'MYOC 3 novel specific_protein -0.52168 0.11311 5.1121077611774e-06 yes MYOC Olink DEVELOPMENT(v.3511) MYOC chr1 171635417 171652688 -1 4653 protein_coding 1:171648625 4063 26_4_1 SeqId_12395_86 'SYDM chr1:173697103_D_I$SeqId_12395_86 1 chr1:173697103_D_I rs199818983 cis 1 173697103 D I 0.2715 -0.2054 0.0142 2.39e-47 'Aspartate--tRNA ligase, mitochondrial ENSG00000117593 'DARS2 intron_variant ENSG00000117593 ENSG00000117593 'DARS2 3 known suggestive_specific_pathway DARS2 chr1 173824653 173858808 1 55157 protein_coding 1:173727965 96688 26_4_2 SeqId_12432_23 'CYBP chr1:174946057_A_G$SeqId_12432_23 1 chr1:174946057_A_G rs61828152 cis 1 174946057 A G 0.1152 -0.3595 0.0194 8.17e-77 'Calcyclin-binding protein ENSG00000116161 'CACYBP intron_variant ENSG00000116161 ENSG00000116161 'CACYBP 3 known suggestive_specific_pathway CACYBP chr1 174999163 175012027 1 27101 protein_coding 1:174976920 22243 26_5_1 SeqId_11302_237 'TENR chr1:175569047_A_G$SeqId_11302_237 1 chr1:175569047_A_G rs2235256 cis 1 175569047 A G 0.5685 0.2162 0.0132 9.65e-61 'Tenascin-R ENSG00000116147 'TNR intron_variant ENSG00000116147 ENSG00000116147 'TNR 3 novel specific_protein 0.43488 0.059052 7.79830110523258e-13 yes TN-R Olink NEUROLOGY(v.8011) TNR chr1 175315194 175743616 -1 7143 protein_coding 1:175599911 143705 260_1_2 SeqId_16606_85 'Aldose reductase chr7:134191842_A_C$SeqId_16606_85 1 chr7:134191842_A_C rs796703 cis 7 134191842 A C 0.0333 0.3959 0.0354 5.54e-29 'Aldose reductase ENSG00000085662 'AKR1B1 intergenic_variant ENSG00000085662 ENSG00000085662 'AKR1B1 3 novel specific_protein AKR1B1 chr7 134442356 134459284 -1 231 protein_coding 7:134507090 47806 262_1_1 SeqId_3045_72 'PTN chr7:137013466_A_G$SeqId_3045_72 1 chr7:137013466_A_G rs10255150 cis 7 137013466 A G 0.4227 0.1686 0.0113 4.34e-50 'Pleiotrophin ENSG00000105894 'PTN intron_variant ENSG00000105894 ENSG00000105894 'PTN 3 known specific_protein PTN chr7 137227341 137343774 -1 5764 protein_coding 7:137328719 15055 263_1_1 SeqId_5034_79 'Trypsin 2 chr7:142498523_C_T$SeqId_5034_79 1 chr7:142498523_C_T rs1799886 cis 7 142498523 T C 0.5704 -0.2405 0.0136 7.79e-70 'Trypsin-2 ENSG00000275896 'PRSS2 upstream_gene_variant ENSG00000275896 ENSG00000275896 'PRSS2 3 known suggestive_specific_pathway PRSS2 chr7 142760398 142774564 1 5645 protein_coding 7:142800839 40441 263_1_2 SeqId_5078_82 'EphB6 chr7:142552547_A_G$SeqId_5078_82 1 chr7:142552547_A_G rs7789303 cis 7 142552547 A G 0.7347 0.3506 0.014 4.94e-138 'Ephrin type-B receptor 6 ENSG00000106123 'EPHB6 upstream_gene_variant ENSG00000106123 ENSG00000106123 'EPHB6 3 known specific_protein 0.36008 0.06833 2.06728331753761e-07 yes EPHB6 Olink NEUROLOGY(v.8011) EPHB6 chr7 142855061 142871094 1 2051 protein_coding 7:142854785 276 263_2_2 SeqId_6060_2 'PIP chr7:142836203_A_T$SeqId_6060_2 1 chr7:142836203_A_T rs73170678 cis 7 142836203 A T 0.8567 -0.5045 0.0187 9.51e-160 'Prolactin-inducible protein ENSG00000159763 'PIP missense_variant ENSG00000159763 ENSG00000159763 'PIP 3 known suggestive_specific_pathway PIP chr7 143132077 143139739 1 5304 protein_coding 7:143139110 7033 263_2_3 SeqId_3431_54 'EphA1 chr7:143097100_A_G$SeqId_3431_54 1 chr7:143097100_A_G rs4725617 cis 7 143097100 A G 0.0742 -1.2789 0.0214 3.92e-778 'Ephrin type-A receptor 1 ENSG00000146904 'EPHA1 missense_variant ENSG00000146904 ENSG00000146904 'EPHA1 3 known suggestive_specific_pathway EPHA1 chr7 143390289 143408856 -1 2041 protein_coding 7:143400007 8849 264_1_1 SeqId_6965_19 'CNTP2 chr7:145360660_C_G$SeqId_6965_19 1 chr7:145360660_C_G rs6969311 cis 7 145360660 C G 0.2822 0.556 0.0131 1.28e-393 'Contactin-associated protein-like 2 ENSG00000174469 'CNTNAP2 intergenic_variant ENSG00000174469 ENSG00000174469 'CNTNAP2 3 known specific_protein 0.4199 0.059166 4.56036915951297e-12 yes CNTNAP2 Olink IMMUNE RESPONSE(v.3202) CNTNAP2 chr7 146116002 148420998 1 26047 protein_coding 7:145663567 452435 266_1_1 SeqId_3079_62 'TIG2 chr7:150039555_C_T$SeqId_3079_62 1 chr7:150039555_C_T rs3735167 cis 7 150039555 T C 0.2593 0.3405 0.0149 5.54e-115 'Retinoic acid receptor responder protein 2 ENSG00000106538 'RARRES2 upstream_gene_variant ENSG00000106538 ENSG00000106538 'RARRES2 3 known specific_protein 0.18046 0.068772 0.00896602612564298 yes RARRES2 Olink CARDIOVASCULAR III(v.6112) RARRES2 chr7 150338317 150341662 -1 5919 protein_coding 7:150342466 804 266_1_3 SeqId_15486_126 'ABP1 chr7:150523544_A_G$SeqId_15486_126 1 chr7:150523544_A_G rs10452848 cis 7 150523544 A G 0.5486 -0.7949 0.0108 4.99e-1179 'Amiloride-sensitive amine oxidase [copper-containing] ENSG00000002726 'AOC1 intron_variant 0.279983 rs10156191 ENSG00000002726 'AOC1 missense_variant ENSG00000002726 ENSG00000002726 'AOC1 3 known specific_protein -0.21205 0.062688 0.00077642587471211 yes AOC1 Olink NEURO EXPLORATORY(v.3901) AOC1 chr7 150824627 150861504 1 26 protein_coding 7:150826456 1829 267_1_1 SeqId_11606_22 'DNJB6 chr7:157145474_C_T$SeqId_11606_22 1 chr7:157145474_C_T rs12668458 cis 7 157145474 T C 0.5404 -0.1792 0.0126 6.91e-46 'DnaJ homolog subfamily B member 6 ENSG00000105993 'DNAJB6 intron_variant ENSG00000105993 ENSG00000105993 'DNAJB6 5 novel unspecific_effect DNAJB6 chr7 157335381 157417439 1 10049 protein_coding 7:157352780 17399 268_1_1 SeqId_2602_2 'Angiopoietin-2 chr8:6279511_C_T$SeqId_2602_2 1 chr8:6279511_C_T rs1968586 cis 8 6279511 T C 0.3495 -0.1025 0.0136 5.58e-14 'Angiopoietin-2 ENSG00000091879 'ANGPT2 intron_variant ENSG00000091879 ENSG00000091879 'ANGPT2 3 known specific_protein ANGPT2 chr8 6499632 6563409 -1 285 protein_coding 8:6421990 141419 268_1_2 SeqId_6629_3 'HBD-1 chr8:6725969_G_T$SeqId_6629_3 1 chr8:6725969_G_T rs2741117 cis 8 6725969 T G 0.5174 0.4168 0.0131 1.03e-222 'Beta-defensin 1 ENSG00000164825 'DEFB1 downstream_gene_variant ENSG00000164825 ENSG00000164825 'DEFB1 3 known specific_protein DEFB1 chr8 6870592 6877936 -1 1672 protein_coding 8:6868447 9489 268_1_4 SeqId_16785_45 'HD-5 chr8:6913026_C_T$SeqId_16785_45 1 chr8:6913026_C_T rs7839771 cis 8 6913026 T C 0.0166 -0.4032 0.057 1.46e-12 'Defensin-5 ENSG00000164816 'DEFA5 missense_variant ENSG00000164816 ENSG00000164816 'DEFA5 3 novel specific_protein DEFA5 chr8 7055304 7056739 -1 1670 protein_coding 8:7055504 1235 269_4_2 SeqId_8007_19 'Cathepsin B chr8:11703657_C_T$SeqId_8007_19 1 chr8:11703657_C_T rs1736084 cis 8 11703657 T C 0.2643 0.6205 0.0141 5.32e-423 'Cathepsin B ENSG00000164733 'CTSB intron_variant 0.217358 rs12338 ENSG00000164733 'CTSB missense_variant ENSG00000164733 ENSG00000164733 'CTSB 3 known unspecific_effect CTSB chr8 11842524 11869533 -1 1508 protein_coding 8:11846148 23385 27_1_1 SeqId_11142_11 'ANGL1 chr1:178523947_C_T$SeqId_11142_11 1 chr1:178523947_C_T rs4548397 cis 1 178523947 T C 0.4686 0.4044 0.0126 7.65e-225 'Angiopoietin-related protein 1 ENSG00000116194 'ANGPTL1 intergenic_variant ENSG00000116194 ENSG00000116194 'ANGPTL1 3 known specific_protein 0.19532 0.063658 0.0022740499508959 yes ANGPTL1 Olink METABOLISM(v.3402) ANGPTL1 chr1 178849535 178871077 -1 9068 protein_coding 1:178554812 316265 27_2_1 SeqId_17682_1 'CD46 chr1:179473273_C_T$SeqId_17682_1 1 chr1:179473273_C_T rs72704449 trans 1 179473273 T C 0.9595 -0.2629 0.0354 1.07e-13 'Membrane cofactor protein ENSG00000117335 'CD46 intron_variant 0.885176 rs61747728 ENSG00000116218 'NPHS2 missense_variant ENSG00000116218 ENSG00000116218 'NPHS2 3 known unspecific_effect -0.00018968 0.16163 0.999064115011574 no CD46 Olink CARDIOMETABOLIC(v.3602) CD46 chr1 207752054 207795513 1 4179 protein_coding 1:179504138 28247916 27_2_2 SeqId_7198_197 'FA20B chr1:179057597_A_C$SeqId_7198_197 1 chr1:179057597_A_C rs45499094 cis 1 179057597 A C 0.0821 -0.1992 0.0241 1.22e-16 'Glycosaminoglycan xylosylkinase ENSG00000116199 'FAM20B intron_variant ENSG00000116199 ENSG00000116199 'FAM20B 3 known specific_protein FAM20B chr1 179025804 179076567 1 9917 protein_coding 1:179088462 62658 27_2_3 SeqId_5261_13 'ABL2 chr1:179103834_C_T$SeqId_5261_13 1 chr1:179103834_C_T rs72709461 cis 1 179103834 T C 0.8877 -0.1415 0.0205 5.66e-12 'Abelson tyrosine-protein kinase 2 ENSG00000143322 'ABL2 intron_variant ENSG00000143322 ENSG00000143322 'ABL2 3 known specific_protein ABL2 chr1 179099330 179229684 -1 27 protein_coding 1:179134699 94985 270_1_1 SeqId_15533_97 'Macrophage scavenger receptor chr8:16012594_A_G$SeqId_15533_97 1 chr8:16012594_A_G rs41341748 cis 8 16012594 A G 0.0111 -1.3839 0.0596 4.33e-119 'Macrophage scavenger receptor types I and II ENSG00000038945 'MSR1 stop_gained ENSG00000038945 ENSG00000038945 'MSR1 7 novel unspecific_effect -2.0284 0.26809 1.9815270258051e-13 yes MSR1 Olink NEUROLOGY(v.8011) MSR1 chr8 16107878 16567490 -1 4481 protein_coding 8:16155085 412405 270_2_1 SeqId_9713_67 'PGFRL chr8:17455059_D_I$SeqId_9713_67 1 chr8:17455059_D_I rs74894178 cis 8 17455059 D I 0.0345 -0.69 0.038 1.32e-73 'Platelet-derived growth factor receptor-like protein ENSG00000104213 'PDGFRL intron_variant ENSG00000104213 ENSG00000104213 'PDGFRL 3 novel specific_protein PDGFRL chr8 17576433 17644071 1 5157 protein_coding 8:17597550 21117 270_2_2 SeqId_5581_28 'FGL1 chr8:17737357_C_T$SeqId_5581_28 1 chr8:17737357_C_T rs7815429 cis 8 17737357 T C 0.3141 -0.5344 0.0122 4.11e-419 'Fibrinogen-like protein 1 ENSG00000104760 'FGL1 intron_variant 0.987899 rs3739406 ENSG00000104760 'FGL1 missense_variant ENSG00000104760 ENSG00000104760 'FGL1 3 known suggestive_specific_pathway FGL1 chr8 17864380 17910365 -1 2267 protein_coding 8:17879848 30517 272_1_1 SeqId_2515_14 'GFRa-2 chr8:21550768_A_C$SeqId_2515_14 1 chr8:21550768_A_C rs15881 cis 8 21550768 A C 0.5342 -0.3449 0.0136 2.48e-141 'GDNF family receptor alpha-2 ENSG00000168546 'GFRA2 3_prime_UTR_variant 0.771153 rs1128397 ENSG00000168546 'GFRA2 missense_variant ENSG00000168546 ENSG00000168546 'GFRA2 3 known specific_protein -0.32173 0.062339 3.59749335155742e-07 yes GFRA2 Olink CELL REGULATION(v.3701) GFRA2 chr8 21690398 21812357 -1 2675 protein_coding 8:21693256 119101 273_1_1 SeqId_4930_21 'Stanniocalcin-1 chr8:23728824_D_I$SeqId_4930_21 1 chr8:23728824_D_I rs141393738 cis 8 23728824 D I 0.9192 -0.2358 0.0247 1.54e-21 'Stanniocalcin-1 ENSG00000159167 'STC1 intergenic_variant ENSG00000159167 ENSG00000159167 'STC1 3 novel specific_protein STC1 chr8 23841929 23854806 -1 6781 protein_coding 8:23871312 16506 275_1_1 SeqId_10419_1 'SCAR5 chr8:27804449_D_I$SeqId_10419_1 1 chr8:27804449_D_I rs566279589 cis 8 27804449 D I 0.7097 0.2116 0.0142 1.85e-50 'Scavenger receptor class A member 5 ENSG00000168079 'SCARA5 intron_variant ENSG00000168079 ENSG00000168079 'SCARA5 6 known unspecific_effect 0.38536 0.0615 8.24138115013003e-10 yes SCARA5 Olink NEUROLOGY(v.8011) SCARA5 chr8 27869883 27992673 -1 286133 protein_coding 8:27946933 45740 276_1_1 SeqId_19273_3 'Glutathione reductase chr8:30553430_A_G$SeqId_19273_3 1 chr8:30553430_A_G rs4733505 cis 8 30553430 A G 0.3527 -0.1503 0.014 1.02e-26 'Glutathione reductase, mitochondrial ENSG00000104687 'GSR intron_variant ENSG00000104687 ENSG00000104687 'GSR 3 novel specific_protein GSR chr8 30678066 30727846 -1 2936 protein_coding 8:30695913 31933 277_1_1 SeqId_7156_2 'FUT10 chr8:33327402_C_T$SeqId_7156_2 1 chr8:33327402_C_T rs62510527 cis 8 33327402 T C 0.5946 -0.5246 0.0121 1.25e-410 'Alpha-(1,3)-fucosyltransferase 10 ENSG00000172728 'FUT10 intron_variant 0.169835 rs17855838 ENSG00000172728 'FUT10 missense_variant ENSG00000172728 ENSG00000172728 'FUT10 3 known specific_protein FUT10 chr8 33370824 33473146 -1 84750 protein_coding 8:33469884 3262 277_1_2 SeqId_16307_22 'UNC5H4 chr8:35136103_D_I$SeqId_16307_22 1 chr8:35136103_D_I rs139942721 cis 8 35136103 D I 0.4138 -0.1133 0.0128 9.71e-19 'Netrin receptor UNC5D ENSG00000156687 'UNC5D intron_variant ENSG00000156687 ENSG00000156687 'UNC5D 3 known specific_protein UNC5D chr8 35235475 35796550 1 137970 protein_coding 8:35278586 43111 278_1_1 SeqId_5532_53 'bFGF-R chr8:38323765_C_G$SeqId_5532_53 1 chr8:38323765_C_G rs62505473 cis 8 38323765 C G 0.587 -0.117 0.0137 1.6e-17 'Fibroblast growth factor receptor 1 ENSG00000077782 'FGFR1 intron_variant ENSG00000077782 ENSG00000077782 'FGFR1 3 novel specific_protein FGFR1 chr8 38400215 38468834 -1 2260 protein_coding 8:38466247 2587 279_1_1 SeqId_3221_54 'SARP-2 chr8:40927477_C_G$SeqId_3221_54 1 chr8:40927477_C_G rs28718791 cis 8 40927477 C G 0.1483 -0.2588 0.0178 8.07e-48 'Secreted frizzled-related protein 1 ENSG00000104332 'SFRP1 intergenic_variant ENSG00000104332 ENSG00000104332 'SFRP1 3 novel specific_protein -0.25243 0.088995 0.00475335225942805 yes SFRP1 Olink NEURO EXPLORATORY(v.3901) SFRP1 chr8 41261962 41309473 -1 6422 protein_coding 8:41069958 239515 279_2_1 SeqId_2212_69 'tPA chr8:42043637_A_C$SeqId_2212_69 1 chr8:42043637_A_C rs8178885 cis 8 42043637 A C 0.0245 -0.5621 0.0407 2.68e-43 'Tissue-type plasminogen activator ENSG00000104368 'PLAT intron_variant 1.0 rs2020921 ENSG00000104368 'PLAT missense_variant ENSG00000104368 ENSG00000104368 'PLAT 3 known specific_protein -0.28432 0.20597 0.168108626558956 no t-PA Olink CARDIOVASCULAR III(v.6112) PLAT chr8 42174718 42207709 -1 5327 protein_coding 8:42186119 21590 28_1_1 SeqId_19238_12 'GLNA chr1:182272178_D_I$SeqId_19238_12 1 chr1:182272178_D_I rs543680930 cis 1 182272178 D I 0.7804 0.1409 0.0157 3.33e-19 'Glutamine synthetase ENSG00000135821 'GLUL intron_variant,non_coding_transcript_variant ENSG00000135821 ENSG00000135821 'GLUL 3 novel specific_protein GLUL chr1 182378098 182392206 -1 2752 protein_coding 1:182303044 89162 28_2_1 SeqId_19496_1 'NPL chr1:182781838_C_T$SeqId_19496_1 1 chr1:182781838_C_T rs74844585 cis 1 182781838 T C 0.0314 0.5261 0.0373 3.68e-45 'N-acetylneuraminate lyase ENSG00000135838 'NPL intron_variant ENSG00000135838 ENSG00000135838 'NPL 3 novel specific_protein NPL chr1 182789293 182830384 1 80896 protein_coding 1:182812703 23410 28_2_3 SeqId_18347_15 'Laminin-2 chr1:183036789_D_I$SeqId_18347_15 1 chr1:183036789_D_I rs533016075 cis 1 183036789 D I 0.8707 -0.183 0.0202 1.4e-19 'Laminin-2 ENSG00000091136|ENSG00000135862|ENSG00000196569 'LAMB1|LAMC1|LAMA2 intron_variant 0.110297 rs20558 ENSG00000135862 'LAMC1 missense_variant ENSG00000091136|ENSG00000135862|ENSG00000196569 ENSG00000091136|ENSG00000135862|ENSG00000196569 'LAMA2|LAMB1|LAMC1 3 novel specific_pathway LAMC1 chr1 183023420 183145592 1 3915 protein_coding 1:183067655 44235 28_2_4 SeqId_9580_5 'Laminin gamma-2 chr1:183155305_A_G$SeqId_9580_5 1 chr1:183155305_A_G rs2276543 cis 1 183155305 A G 0.279 0.5757 0.0135 2.39e-397 'Laminin subunit gamma-2 ENSG00000058085 'LAMC2 upstream_gene_variant ENSG00000058085 ENSG00000058085 'LAMC2 3 known unspecific_effect LAMC2 chr1 183186238 183245127 1 3918 protein_coding 1:183186170 68 281_1_1 SeqId_3453_87 'LYN chr8:56793239_A_G$SeqId_3453_87 1 chr8:56793239_A_G rs6983130 cis 8 56793239 A G 0.8113 -0.1176 0.0161 2.78e-13 'Tyrosine-protein kinase Lyn ENSG00000254087 'LYN intron_variant ENSG00000254087 ENSG00000254087 'LYN 3 novel specific_pathway LYN chr8 55879835 56014169 1 4067 protein_coding 8:55880680 845 281_2_1 SeqId_9076_25 'PENK chr8:57379532_D_I$SeqId_9076_25 1 chr8:57379532_D_I rs34217211 cis 8 57379532 D I 0.4689 -0.412 0.0125 1.41e-236 'Proenkephalin-A ENSG00000181195 'PENK intron_variant ENSG00000181195 ENSG00000181195 'PENK 3 known specific_protein PENK chr8 56436674 56446671 -1 5179 protein_coding 8:56466974 20303 281_2_2 SeqId_9231_23 'IMPA3 chr8:57876576_C_T$SeqId_9231_23 1 chr8:57876576_C_T rs112433249 cis 8 57876576 T C 0.9891 1.6979 0.0637 1.0e-156 'Inositol monophosphatase 3 ENSG00000104331 'IMPAD1 missense_variant ENSG00000104331 ENSG00000104331 'BPNT2 3 known specific_protein BPNT2 chr8 56957931 56993867 -1 54928 protein_coding 8:56964017 29850 282_1_2 SeqId_11390_24 'Carbonic Anhydrase VIII chr8:61191674_D_I$SeqId_11390_24 1 chr8:61191674_D_I rs140904427 cis 8 61191674 D I 0.3987 0.2901 0.0133 7.08e-105 'Carbonic anhydrase-related protein ENSG00000178538 'CA8 intron_variant ENSG00000178538 ENSG00000178538 'CA8 3 known specific_protein CA8 chr8 60185412 60281400 -1 767 protein_coding 8:60279116 2284 282_2_1 SeqId_6998_106 'HAAH chr8:62660578_A_G$SeqId_6998_106 1 chr8:62660578_A_G rs2350578 cis 8 62660578 A G 0.6475 0.1982 0.0135 1.03e-48 'Aspartyl/asparaginyl beta-hydroxylase ENSG00000198363 'ASPH regulatory_region_variant 0.260383 rs545836309 ENSG00000198363 'ASPH splice_acceptor_variant ENSG00000198363 ENSG00000198363 'ASPH 3 known specific_protein ASPH chr8 61500556 61714640 -1 444 protein_coding 8:61748019 33379 282_3_1 SeqId_9370_69 'GGH chr8:63943175_C_T$SeqId_9370_69 1 chr8:63943175_C_T rs12676348 cis 8 63943175 T C 0.9367 -0.9079 0.0263 8.26e-261 'Gamma-glutamyl hydrolase ENSG00000137563 'GGH intron_variant ENSG00000137563 ENSG00000137563 'GGH 3 known specific_protein GGH chr8 63014881 63039407 -1 8836 protein_coding 8:63030616 8791 283_1_1 SeqId_9095_5 'MTFR1 chr8:66566815_D_I$SeqId_9095_5 1 chr8:66566815_D_I rs140729430 cis 8 66566815 D I 0.7694 0.1786 0.0161 1.85e-28 'Mitochondrial fission regulator 1 ENSG00000066855 'MTFR1 intron_variant ENSG00000066855 ENSG00000066855 'MTFR1 3 novel specific_protein MTFR1 chr8 65644734 65771261 1 9650 protein_coding 8:65654581 9847 283_1_2 SeqId_10042_8 'SGK3 chr8:67687500_A_G$SeqId_10042_8 1 chr8:67687500_A_G rs142632105 cis 8 67687500 A G 0.0138 0.4397 0.0593 1.23e-13 'Serine/threonine-protein kinase Sgk3 ENSG00000104205 'SGK3 5_prime_UTR_variant ENSG00000104205 ENSG00000104205 'SGK3 3 novel specific_protein SGK3 chr8 66712734 66862022 1 23678 protein_coding 8:66775265 62531 285_1_1 SeqId_3647_49 'TLR4:MD-2 complex chr8:74917084_A_G$SeqId_3647_49 1 chr8:74917084_A_G rs6472812 cis 8 74917084 A G 0.0401 -0.4001 0.0339 3.29e-32 'Toll-like receptor 4:Lymphocyte antigen 96 complex ENSG00000136869|ENSG00000154589 'TLR4|LY96 missense_variant ENSG00000136869|ENSG00000154589 ENSG00000136869|ENSG00000154589 'LY96|TLR4 3 known specific_protein LY96 chr8 73991392 74029079 1 23643 protein_coding 8:74004849 13457 286_1_1 SeqId_17796_15 'IMPA1 chr8:82565202_A_G$SeqId_17796_15 1 chr8:82565202_A_G rs2142316 cis 8 82565202 A G 0.7024 0.1102 0.0146 5.21e-14 'Inositol monophosphatase 1 ENSG00000133731 'IMPA1 downstream_gene_variant ENSG00000133731 ENSG00000133731 'IMPA1 3 novel specific_protein 0.22952 0.070732 0.00125602996369488 yes IMPA1 Olink NEURO EXPLORATORY(v.3901) IMPA1 chr8 81656914 81686331 -1 3612 protein_coding 8:81652967 33364 286_1_2 SeqId_19173_5 'ZFAN1 chr8:82600027_A_T$SeqId_19173_5 1 chr8:82600027_A_T rs2912817 cis 8 82600027 A T 0.8323 -0.2869 0.0173 1.48e-61 'AN1-type zinc finger protein 1 ENSG00000104231 'ZFAND1 upstream_gene_variant ENSG00000104231 ENSG00000104231 'ZFAND1 3 novel specific_protein ZFAND1 chr8 81701334 81732903 -1 79752 protein_coding 8:81687792 45111 287_1_1 SeqId_4969_2 'Carbonic anhydrase I chr8:86187573_C_G$SeqId_4969_2 1 chr8:86187573_C_G rs10098816 cis 8 86187573 C G 0.0128 -0.448 0.0611 2.16e-13 'Carbonic anhydrase 1 ENSG00000133742 'CA1 intron_variant 0.716144 rs61734485 ENSG00000133742 'CA1 missense_variant ENSG00000133742 ENSG00000133742 'CA1 3 novel specific_protein CA1 chr8 85327608 85379014 -1 759 protein_coding 8:85275344 103670 287_1_2 SeqId_3420_21 'Carbonic anhydrase XIII chr8:86197127_G_T$SeqId_3420_21 1 chr8:86197127_G_T rs73688702 cis 8 86197127 T G 0.0632 -0.7824 0.0247 1.7e-220 'Carbonic anhydrase 13 ENSG00000185015 'CA13 downstream_gene_variant ENSG00000185015 ENSG00000185015 'CA13 3 known specific_protein -0.7474 0.12213 1.94043902355183e-09 yes CA13 Olink METABOLISM(v.3402) CA13 chr8 85220587 85284073 1 377677 protein_coding 8:85284898 64311 287_1_3 SeqId_3799_11 'Carbonic anhydrase III chr8:86351051_C_G$SeqId_3799_11 1 chr8:86351051_C_G rs2072696 cis 8 86351051 C G 0.2436 -0.2093 0.0151 6.71e-44 'Carbonic anhydrase 3 ENSG00000164879 'CA3 upstream_gene_variant 0.470637 rs20571 ENSG00000164879 'CA3 missense_variant ENSG00000164879 ENSG00000164879 'CA3 3 known suggestive_specific_pathway CA3 chr8 85373436 85449040 1 761 protein_coding 8:85438822 65386 287_2_1 SeqId_7096_30 'RMD1 chr8:87484913_A_G$SeqId_7096_30 1 chr8:87484913_A_G rs13042 cis 8 87484913 A G 0.2833 -0.3473 0.0134 1.36e-147 'Regulator of microtubule dynamics protein 1 ENSG00000176623 'RMDN1 3_prime_UTR_variant 0.147481 rs6980476 ENSG00000176623 'RMDN1 missense_variant ENSG00000176623 ENSG00000176623 'RMDN1 3 known specific_protein RMDN1 chr8 86468257 86514357 -1 51115 protein_coding 8:86472684 41673 288_1_1 SeqId_9719_145 'MMP-16 chr8:89348016_C_T$SeqId_9719_145 1 chr8:89348016_C_T rs4961089 cis 8 89348016 T C 0.6879 -0.2692 0.0144 8.53e-78 'Matrix metalloproteinase-16 ENSG00000156103 'MMP16 intron_variant,non_coding_transcript_variant ENSG00000156103 ENSG00000156103 'MMP16 3 known specific_pathway MMP16 chr8 88032011 88328025 -1 4325 protein_coding 8:88335787 7762 29_1_1 SeqId_13982_33 'RGS18 chr1:192162949_C_T$SeqId_13982_33 1 chr1:192162949_C_T rs1175169 cis 1 192162949 T C 0.5096 0.1241 0.0127 2.03e-22 'Regulator of G-protein signaling 18 ENSG00000150681 'RGS18 intergenic_variant ENSG00000150681 ENSG00000150681 'RGS18 3 novel specific_protein RGS18 chr1 192158462 192185815 1 64407 protein_coding 1:192193819 35357 29_1_2 SeqId_12486_8 'GLRX2 chr1:193074511_A_G$SeqId_12486_8 1 chr1:193074511_A_G rs148212596 cis 1 193074511 A G 0.9811 -1.2211 0.0463 2.14e-153 'Glutaredoxin-2, mitochondrial ENSG00000023572 'GLRX2 intron_variant ENSG00000023572 ENSG00000023572 'GLRX2 3 known specific_protein GLRX2 chr1 193090866 193106114 -1 51022 protein_coding 1:193105381 733 290_1_1 SeqId_16613_3 'CAD17 chr8:95203825_D_I$SeqId_16613_3 1 chr8:95203825_D_I 8:95203825_I_D cis 8 95203825 D I 0.473 -0.3557 0.013 4.18e-164 'Cadherin-17 ENSG00000079112 'CDH17 intron_variant 0.166525 rs2243518 ENSG00000079112 'CDH17 missense_variant ENSG00000079112 ENSG00000079112 'CDH17 3 novel specific_protein -0.36402 0.05915 1.58489319246111e-09 yes CDH17 Olink NEURO EXPLORATORY(v.3901) CDH17 chr8 94127162 94217303 -1 1015 protein_coding 8:94191597 25706 291_1_1 SeqId_3325_2 'MATN2 chr8:99045866_A_G$SeqId_3325_2 1 chr8:99045866_A_G rs17831160 cis 8 99045866 A G 0.0323 0.5048 0.035 3.75e-47 'Matrilin-2 ENSG00000132561 'MATN2 missense_variant ENSG00000132561 ENSG00000132561 'MATN2 6 novel suggestive_specific_pathway 0.18894 0.21885 0.388400696468028 no MATN2 Olink DEVELOPMENT(v.3511) MATN2 chr8 97868840 98036724 1 4147 protein_coding 8:98033638 164798 291_1_2 SeqId_9394_19 'Aminopeptidase chr8:98041637_A_G$SeqId_9394_19 1 chr8:98041637_A_G rs148684432 cis 8 98041637 A G 0.0105 -1.6733 0.0632 1.64e-154 'Carboxypeptidase Q ENSG00000104324 'CPQ missense_variant ENSG00000104324 ENSG00000104324 'CPQ 3 known specific_protein CPQ chr8 96645242 97149654 1 10404 protein_coding 8:97029409 384167 291_1_3 SeqId_14636_25 'Ribonuclease UK114 chr8:99120794_D_I$SeqId_14636_25 1 chr8:99120794_D_I rs77539382 cis 8 99120794 D I 0.6798 0.3398 0.0138 6.73e-134 'Ribonuclease UK114 ENSG00000132541 'HRSP12 intron_variant ENSG00000132541 ENSG00000132541 'RIDA 3 known specific_protein RIDA chr8 98102344 98117171 -1 10247 protein_coding 8:98108567 8604 292_1_3 SeqId_8925_25 'RIR2B chr8:103244599_A_C$SeqId_8925_25 1 chr8:103244599_A_C rs16869295 cis 8 103244599 A C 0.9345 -0.4685 0.0252 4.12e-77 'Ribonucleoside-diphosphate reductase subunit M2 B ENSG00000048392 'RRM2B intron_variant ENSG00000048392 ENSG00000048392 'RRM2B 3 known specific_protein -0.30748 0.11173 0.00614893638512627 yes RRM2B Olink ORGAN DAMAGE(v.3301) RRM2B chr8 102204502 102238961 -1 50484 protein_coding 8:102232371 6590 293_1_1 SeqId_15506_34 'LRP12 chr8:105481705_C_T$SeqId_15506_34 1 chr8:105481705_C_T rs2942570 cis 8 105481705 T C 0.4032 -0.1043 0.014 9.05e-14 'Low-density lipoprotein receptor-related protein 12 ENSG00000147650 'LRP12 upstream_gene_variant ENSG00000147650 ENSG00000147650 'LRP12 3 known specific_protein LRP12 chr8 104489231 104589258 -1 29967 protein_coding 8:104469477 119781 294_1_3 SeqId_2811_27 'Angiopoietin-1 chr8:106581528_A_T$SeqId_2811_27 1 chr8:106581528_A_T rs6993770 trans 8 106581528 A T 0.7172 0.1333 0.0144 2.76e-20 'Angiopoietin-1 ENSG00000154188 'ANGPT1 intron_variant ENSG00000169946 ENSG00000147650|ENSG00000169946 'LRP12|ZFPM2 1 known unspecific_effect ANGPT1 chr8 107249482 107498055 -1 284 protein_coding 8:105569300 1928755 294_1_3 SeqId_3365_7 'Dkk-4 chr8:106581528_A_T$SeqId_3365_7 1 chr8:106581528_A_T rs6993770 trans 8 106581528 A T 0.7172 0.1418 0.014 3.4e-24 'Dickkopf-related protein 4 ENSG00000104371 'DKK4 intron_variant ENSG00000169946 ENSG00000147650|ENSG00000169946 'LRP12|ZFPM2 1 known unspecific_effect DKK4 chr8 42374063 42377229 -1 27121 protein_coding 8:105569300 63192071 296_1_1 SeqId_6558_5 'COL10 chr8:120141923_G_T$SeqId_6558_5 1 chr8:120141923_G_T rs72682450 cis 8 120141923 T G 0.013 -0.5374 0.0651 1.55e-16 'Collectin-10 ENSG00000184374 'COLEC10 intergenic_variant ENSG00000184374 ENSG00000184374 'COLEC10 5 novel suggestive_specific_pathway COLEC10 chr8 118995452 119108455 1 10584 protein_coding 8:119129684 134232 296_1_3 SeqId_8304_50 'OPG chr8:120155591_C_T$SeqId_8304_50 1 chr8:120155591_C_T rs13257113 cis 8 120155591 T C 0.563 0.1443 0.013 1.86e-28 'Tumor necrosis factor receptor superfamily member 11B ENSG00000164761 'TNFRSF11B intergenic_variant ENSG00000164761 ENSG00000164761 'TNFRSF11B 3 known unspecific_effect 0.36499 0.062281 8.55657576098093e-09 yes OPG Olink CARDIOVASCULAR III(v.6112) TNFRSF11B chr8 118923557 118951885 -1 4982 protein_coding 8:119143352 191467 296_1_4 SeqId_2737_22 'NovH chr8:120400532_A_G$SeqId_2737_22 1 chr8:120400532_A_G rs34112166 cis 8 120400532 A G 0.2182 0.1397 0.0165 2.23e-17 'Protein NOV homolog ENSG00000136999 'NOV upstream_gene_variant 0.792249 rs2279112 ENSG00000136999 'NOV missense_variant ENSG00000136999 ENSG00000136999 'CCN3 3 known unspecific_effect CCN3 chr8 119416446 119424434 1 4856 protein_coding 8:119388292 28154 296_1_5 SeqId_16892_23 'ENPP2 chr8:120688930_C_T$SeqId_16892_23 1 chr8:120688930_C_T rs10107636 cis 8 120688930 T C 0.3683 -0.2106 0.0116 6.95e-74 'Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 ENSG00000136960 'ENPP2 upstream_gene_variant ENSG00000136960 ENSG00000136960 'ENPP2 3 novel specific_protein -0.20797 0.052988 9.93573500586845e-05 yes ENPP2 Olink DEVELOPMENT(v.3511) ENPP2 chr8 119557086 119673453 -1 5168 protein_coding 8:119676690 3237 299_1_3 SeqId_13692_154 'WISP-1 chr8:134202942_A_C$SeqId_13692_154 1 chr8:134202942_A_C rs2013158 cis 8 134202942 A C 0.2561 0.6795 0.0142 9.83e-500 'WNT1-inducible-signaling pathway protein 1 ENSG00000104415 'WISP1 upstream_gene_variant ENSG00000104415 ENSG00000104415 'CCN4 3 known specific_protein 0.40455 0.070465 1.66571232806881e-08 yes WISP-1 Olink ONCOLOGY II(v.7002) CCN4 chr8 133191039 133231690 1 8840 protein_coding 8:133190699 340 299_1_4 SeqId_5657_28 'SIA4A chr8:134503148_C_T$SeqId_5657_28 1 chr8:134503148_C_T rs9643300 cis 8 134503148 T C 0.5741 -0.2217 0.013 6.39e-65 'CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 ENSG00000008513 'ST3GAL1 intron_variant ENSG00000008513 ENSG00000008513 'ST3GAL1 3 known suggestive_specific_pathway ST3GAL1 chr8 133454848 133571940 -1 6482 protein_coding 8:133490905 81035 3_1_2 SeqId_19523_215 'PARK7 chr1:8021778_C_T$SeqId_19523_215 1 chr1:8021778_C_T rs226249 cis 1 8021778 T C 0.4206 -0.1318 0.0123 1.32e-26 'Protein DJ-1 ENSG00000116288 'PARK7 5_prime_UTR_variant ENSG00000116288 ENSG00000116288 'PARK7 3 known specific_protein -0.14125 0.06018 0.0193241322038104 yes PARK7 Olink DEVELOPMENT(v.3511) PARK7 chr1 7954291 7985505 1 11315 protein_coding 1:7961718 7427 3_1_4 SeqId_3352_80 'Carbonic anhydrase 6 chr1:9034598_A_G$SeqId_3352_80 1 chr1:9034598_A_G rs3765963 cis 1 9034598 A G 0.5935 -0.6211 0.0121 1.11e-574 'Carbonic anhydrase 6 ENSG00000131686 'CA6 downstream_gene_variant 0.799354 rs3765964 ENSG00000131686 'CA6 missense_variant ENSG00000131686 ENSG00000131686 'CA6 3 known specific_protein -0.58187 0.056421 1.12201845430197e-22 yes CA6 Olink DEVELOPMENT(v.3511) CA6 chr1 8945867 8975092 1 765 protein_coding 1:8974539 28672 3_1_5 SeqId_7161_25 'G6PE chr1:9306849_C_T$SeqId_7161_25 1 chr1:9306849_C_T rs2310925 cis 1 9306849 T C 0.6003 0.5037 0.0131 4.94e-323 'GDH/6PGL endoplasmic bifunctional protein ENSG00000049239 'H6PD intron_variant 0.113884 rs34603401 ENSG00000049239 'H6PD missense_variant ENSG00000049239 ENSG00000049239 'H6PD 3 known specific_protein H6PD chr1 9234774 9271337 1 9563 protein_coding 1:9246790 12016 3_2_1 SeqId_15521_4 'Alcadein alpha-1 chr1:9818064_C_G$SeqId_15521_4 1 chr1:9818064_C_G rs116383848 cis 1 9818064 C G 0.0188 2.1381 0.0466 1.29e-459 'Calsyntenin-1 ENSG00000171603 'CLSTN1 intron_variant 0.976394 rs35331030 ENSG00000171603 'CLSTN1 missense_variant ENSG00000171603 ENSG00000171603 'CLSTN1 3 novel specific_protein 0.55774 0.20606 0.00703720171722057 yes CLSTN1 Olink NEURO EXPLORATORY(v.3901) CLSTN1 chr1 9728926 9823984 -1 22883 protein_coding 1:9758006 65978 3_2_2 SeqId_14208_3 'RET7 chr1:10001980_A_T$SeqId_14208_3 1 chr1:10001980_A_T rs1220424 cis 1 10001980 A T 0.7827 0.2213 0.0162 1.78e-42 'Retinoid-binding protein 7 ENSG00000162444 'RBP7 intron_variant ENSG00000162444 ENSG00000162444 'RBP7 3 novel specific_protein RBP7 chr1 9997206 10016021 1 116362 protein_coding 1:9941922 55284 3_4_1 SeqId_13449_25 'SF3B4 chr1:12038990_A_G$SeqId_13449_25 1 chr1:12038990_A_G rs3820189 trans 1 12038990 A G 0.5603 0.1198 0.0136 1.36e-18 'Splicing factor 3B subunit 4 ENSG00000143368 'SF3B4 upstream_gene_variant 0.153626 rs7551175 ENSG00000083444 'PLOD1 missense_variant ENSG00000116688|ENSG00000116670 ENSG00000116688 'MFN2 2 known unspecific_effect SF3B4 chr1 149923317 149927803 -1 10262 protein_coding 1:11978933 137948870 3_4_2 SeqId_8368_102 'TNF sR-II chr1:12254746_D_I$SeqId_8368_102 1 chr1:12254746_D_I rs201538153 cis 1 12254746 D I 0.9583 0.5993 0.0338 2.33e-70 'Tumor necrosis factor receptor superfamily member 1B ENSG00000028137 'TNFRSF1B intron_variant 0.990932 rs5746026 ENSG00000028137 'TNFRSF1B missense_variant ENSG00000028137 ENSG00000028137 'TNFRSF1B 3 known unspecific_effect 0.46007 0.14687 0.00183907736832808 yes TNF-R2 Olink CARDIOVASCULAR III(v.6112) TNFRSF1B chr1 12166991 12209228 1 7133 protein_coding 1:12194690 27699 3_4_2 SeqId_3152_57 'TNF sR-II chr1:12250004_C_T$SeqId_3152_57 1 chr1:12250004_C_T rs5746011 cis 1 12250004 T C 0.9599 0.4418 0.0342 3.72e-38 'Tumor necrosis factor receptor superfamily member 1B ENSG00000028137 'TNFRSF1B intron_variant 0.989517 rs5746026 ENSG00000028137 'TNFRSF1B missense_variant ENSG00000028137 ENSG00000028137 'TNFRSF1B 3 known unspecific_effect 0.48748 0.14374 0.000752488730173584 yes TNF-R2 Olink CARDIOVASCULAR III(v.6112) TNFRSF1B chr1 12166991 12209228 1 7133 protein_coding 1:12189947 22956 3_4_3 SeqId_7655_11 'N-terminal pro-BNP chr1:11915467_C_T$SeqId_7655_11 1 chr1:11915467_C_T rs198379 cis 1 11915467 T C 0.5878 -0.2368 0.0125 8.7e-80 'N-terminal pro-BNP ENSG00000120937 'NPPB downstream_gene_variant ENSG00000120937 ENSG00000120937 'NPPB 3 known unspecific_effect -0.25323 0.057057 1.12486395364678e-05 yes NT-proBNP Olink CARDIOVASCULAR III(v.6112) NPPB chr1 11857464 11858945 -1 4879 protein_coding 1:11855410 3535 3_4_4 SeqId_6538_90 'K2013 chr1:11969786_G_T$SeqId_6538_90 1 chr1:11969786_G_T rs926270 cis 1 11969786 T G 0.5076 -0.1301 0.0135 7.03e-22 'Uncharacterized protein KIAA2013 ENSG00000116685 'KIAA2013 downstream_gene_variant ENSG00000116685 ENSG00000116685 'KIAA2013 3 known specific_protein KIAA2013 chr1 11919591 11926428 -1 90231 protein_coding 1:11909729 16699 30_1_12 SeqId_15584_9 'FHR2 chr1:196920148_C_T$SeqId_15584_9 1 chr1:196920148_C_T rs4085749 cis 1 196920148 T C 0.2284 -1.0427 0.0127 1.75e-1466 'Complement factor H-related protein 2 ENSG00000080910 'CFHR2 synonymous_variant ENSG00000080910 ENSG00000080910|ENSG00000134365 'CFHR2|CFHR4 3 known unspecific_effect CFHR2 chr1 196943738 196959622 1 3080 protein_coding 1:196951018 7280 30_1_12 SeqId_6471_53 'FHR4 chr1:196905205_C_T$SeqId_6471_53 1 chr1:196905205_C_T rs4915363 cis 1 196905205 T C 0.7594 0.7848 0.0142 7.61e-666 'Complement factor H-related protein 4 ENSG00000134365 'CFHR4 intron_variant 0.125367 rs7417769 ENSG00000134365 'CFHR4 missense_variant ENSG00000134365 ENSG00000080910|ENSG00000134365 'CFHR2|CFHR4 3 known unspecific_effect CFHR4 chr1 196888014 196918713 1 10877 protein_coding 1:196936075 48061 30_1_13 SeqId_16927_9 'Coagulation factor XIII chr1:196958298_G_T$SeqId_16927_9 1 chr1:196958298_G_T rs10922151 cis 1 196958298 T G 0.8403 0.7105 0.0168 7.75e-391 'Coagulation factor XIII ENSG00000124491|ENSG00000143278 'F13A1|F13B intron_variant ENSG00000124491|ENSG00000143278 ENSG00000124491|ENSG00000143278 'F13A1|F13B 3 known unspecific_effect F13B chr1 197038741 197067260 -1 2165 protein_coding 1:196989168 78092 30_1_14 SeqId_5658_64 'coagulation factor XIII B chr1:197034826_G_T$SeqId_5658_64 1 chr1:197034826_G_T rs2298882 cis 1 197034826 T G 0.522 0.3978 0.0124 7.27e-226 'Coagulation factor XIII B chain ENSG00000143278 'F13B intron_variant ENSG00000143278 ENSG00000143278 'F13B 3 known unspecific_effect F13B chr1 197038741 197067260 -1 2165 protein_coding 1:197065696 1564 30_1_2 SeqId_11989_35 'EMC1 chr1:196659753_C_T$SeqId_11989_35 1 chr1:196659753_C_T rs34331968 trans 1 196659753 T C 0.5414 -0.1007 0.0133 4.54e-14 'ER membrane protein complex subunit 1 ENSG00000127463 'EMC1 intron_variant 0.543252 rs1061170 ENSG00000000971 'CFH missense_variant none ENSG00000000971|ENSG00000066279|ENSG00000213047 'ASPM|CFH|DENND1B 1 known unspecific_effect EMC1 chr1 19215660 19251552 -1 23065 protein_coding 1:196690623 177439071 30_1_3 SeqId_15468_14 'FHR1 chr1:196821380_G_T$SeqId_15468_14 1 chr1:196821380_G_T rs67908756 cis 1 196821380 T G 0.8029 0.932 0.0138 4.29e-993 'Complement factor H-related protein 1 ENSG00000244414 'CFHR1 intron_variant ENSG00000244414 ENSG00000244414 'CFHR1 4 known unspecific_effect CFHR1 chr1 196819731 196832189 1 3078 protein_coding 1:196852250 32519 30_1_7 SeqId_9092_33 'ANGL1 chr1:196660261_A_G$SeqId_9092_33 1 chr1:196660261_A_G rs10801555 trans 1 196660261 A G 0.3911 0.2253 0.0143 4.57e-56 'Angiopoietin-related protein 1 ENSG00000116194 'ANGPTL1 intron_variant 0.998132 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect 0.10994 0.062363 0.078541646261454 no ANGPTL1 Olink METABOLISM(v.3402) ANGPTL1 chr1 178849535 178871077 -1 9068 protein_coding 1:196691131 17820054 30_1_7 SeqId_5063_12 'CD244 chr1:196664651_C_T$SeqId_5063_12 1 chr1:196664651_C_T rs10922098 trans 1 196664651 T C 0.6073 0.1548 0.0138 2.48e-29 'Natural killer cell receptor 2B4 ENSG00000122223 'CD244 intron_variant 0.999296 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect 0.014771 0.062923 0.814505460136103 no CD244 Olink INFLAMMATION(v.3012) CD244 chr1 160830160 160862887 -1 51744 protein_coding 1:196695521 35832634 30_1_7 SeqId_8767_44 'Endothelin-converting enzyme 1 chr1:196670757_C_T$SeqId_8767_44 1 chr1:196670757_C_T rs4658046 trans 1 196670757 T C 0.6077 -0.3295 0.0134 1.22e-132 'Endothelin-converting enzyme 1 ENSG00000117298 'ECE1 intron_variant 0.99417 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect -0.05152 0.062861 0.412847824096099 no ECE1 Olink NEURO EXPLORATORY(v.3901) ECE1 chr1 21217247 21345572 -1 1889 protein_coding 1:196701627 175356055 30_1_7 SeqId_6617_12 'FCRL6 chr1:196668360_D_I$SeqId_6617_12 1 chr1:196668360_D_I rs34813609 trans 1 196668360 D I 0.6095 -0.2151 0.0137 2.88e-55 'Fc receptor-like protein 6 ENSG00000181036 'FCRL6 intron_variant 0.998117 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect -0.065597 0.062606 0.295263660791663 no FCRL6 Olink IMMUNE RESPONSE(v.3202) FCRL6 chr1 159800511 159816257 1 343413 protein_coding 1:196699231 36898720 30_1_7 SeqId_4909_68 'Galectin-8 chr1:196670839_A_G$SeqId_4909_68 1 chr1:196670839_A_G rs10754199 trans 1 196670839 A G 0.3919 -0.17 0.0143 1.63e-32 'Galectin-8 ENSG00000116977 'LGALS8 intron_variant 0.994172 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect -0.019849 0.062682 0.751640200974172 no gal-8 Olink NEUROLOGY(v.8011) LGALS8 chr1 236518000 236552981 1 3964 protein_coding 1:196701709 39816291 30_1_7 SeqId_10356_21 'c-Jun chr1:196664651_C_T$SeqId_10356_21 1 chr1:196664651_C_T rs10922098 trans 1 196664651 T C 0.6073 -0.2552 0.0136 3.73e-78 'Transcription factor AP-1 ENSG00000177606 'JUN intron_variant 0.999296 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect -0.088986 0.063196 0.159746002817175 no JUN Olink CELL REGULATION(v.3701) JUN chr1 58776845 58784048 -1 3725 protein_coding 1:196695521 137911473 30_1_7 SeqId_10047_12 'NCF-2 chr1:196666044_C_T$SeqId_10047_12 1 chr1:196666044_C_T rs76258507 trans 1 196666044 T C 0.3913 -0.3284 0.0133 2.23e-134 'Neutrophil cytosol factor 2 ENSG00000116701 'NCF2 intron_variant 0.999298 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect -0.035115 0.059861 0.557737698200316 no NCF2 Olink ORGAN DAMAGE(v.3301) NCF2 chr1 183555562 183590876 -1 4688 protein_coding 1:196696914 13106038 30_1_7 SeqId_15430_165 'OPT chr1:196672385_A_G$SeqId_15430_165 1 chr1:196672385_A_G rs203688 trans 1 196672385 A G 0.609 -0.2797 0.0135 9.24e-95 'Opticin ENSG00000188770 'OPTC intron_variant 0.989272 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect -0.11193 0.060702 0.06581122882389 no OPTC Olink CELL REGULATION(v.3701) OPTC chr1 203494153 203508949 1 26254 protein_coding 1:196703255 6790898 30_1_7 SeqId_19545_145 'Oxidized PARK7 chr1:196665208_A_G$SeqId_19545_145 1 chr1:196665208_A_G rs10922100 trans 1 196665208 A G 0.3913 0.3157 0.0135 3.32e-120 'Oxidized Protein deglycase DJ-1 ENSG00000116288 'PARK7 intron_variant 1.0 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect 0.016464 0.062415 0.792063499048971 no PARK7 Olink DEVELOPMENT(v.3511) PARK7 chr1 7954291 7985505 1 11315 protein_coding 1:196696078 188741787 30_1_7 SeqId_2247_20 'EG-VEGF chr1:196661838_D_I$SeqId_2247_20 1 chr1:196661838_D_I rs61229706 trans 1 196661838 D I 0.6194 0.1133 0.014 6.79e-16 'Prokineticin-1 ENSG00000143125 'PROK1 intron_variant 0.959503 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect -0.015375 0.047985 0.748789938243557 no PROK1 Olink CELL REGULATION(v.3701) PROK1 chr1 110451149 110457358 1 84432 protein_coding 1:196692709 86241560 30_1_7 SeqId_11666_72 'RGS8 chr1:196668360_D_I$SeqId_11666_72 1 chr1:196668360_D_I rs34813609 trans 1 196668360 D I 0.6095 -0.3364 0.0133 1.04e-140 'Regulator of G-protein signaling 8 ENSG00000135824 'RGS8 intron_variant 0.998117 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect 0.015396 0.063167 0.807545497404227 no RGS8 Olink CELL REGULATION(v.3701) RGS8 chr1 182641816 182684576 -1 85397 protein_coding 1:196699231 14014655 30_1_7 SeqId_14034_22 'GA733-1 protein chr1:196661838_D_I$SeqId_14034_22 1 chr1:196661838_D_I rs61229706 trans 1 196661838 D I 0.6194 0.189 0.0139 3.45e-42 'Tumor-associated calcium signal transducer 2 ENSG00000184292 'TACSTD2 intron_variant 0.959503 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect -0.079873 0.063327 0.207821272643049 no TACSTD2 Olink CELL REGULATION(v.3701) TACSTD2 chr1 58575433 58577252 -1 4070 protein_coding 1:196692709 138115457 30_1_7 SeqId_2619_72 'GA733-1 protein chr1:196660261_A_G$SeqId_2619_72 1 chr1:196660261_A_G rs10801555 trans 1 196660261 A G 0.3911 -0.116 0.0143 5.8e-16 'Tumor-associated calcium signal transducer 2 ENSG00000184292 'TACSTD2 intron_variant 0.998132 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect 0.089692 0.062126 0.14947205313752 no TACSTD2 Olink CELL REGULATION(v.3701) TACSTD2 chr1 58575433 58577252 -1 4070 protein_coding 1:196691131 138113879 30_1_7 SeqId_11302_237 'TENR chr1:196660261_A_G$SeqId_11302_237 1 chr1:196660261_A_G rs10801555 trans 1 196660261 A G 0.3911 0.1387 0.0139 2.37e-23 'Tenascin-R ENSG00000116147 'TNR intron_variant 0.998132 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect -0.047443 0.062237 0.446262095079473 no TN-R Olink NEUROLOGY(v.8011) TNR chr1 175315194 175743616 -1 7143 protein_coding 1:196691131 20947515 30_1_7 SeqId_3730_81 'TNR4 chr1:196664651_C_T$SeqId_3730_81 1 chr1:196664651_C_T rs10922098 trans 1 196664651 T C 0.6073 0.1426 0.0138 4.22e-25 'Tumor necrosis factor receptor superfamily member 4 ENSG00000186827 'TNFRSF4 intron_variant 0.999296 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect 0.0072484 0.062615 0.907891604316948 no TNFRSF4 Olink ONCOLOGY II(v.7002) TNFRSF4 chr1 1211340 1214153 -1 7293 protein_coding 1:196695521 195481368 30_1_7 SeqId_10396_6 'Mcl-1 chr1:196671666_D_I$SeqId_10396_6 1 chr1:196671666_D_I rs201263987 trans 1 196671666 D I 0.6106 0.1141 0.0138 1.66e-16 'Induced myeloid leukemia cell differentiation protein Mcl-1 ENSG00000143384 'MCL1 intron_variant 0.986979 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect MCL1 chr1 150560895 150579738 -1 4170 protein_coding 1:196702537 46122799 30_1_7 SeqId_10496_11 'CaCC chr1:196658279_C_T$SeqId_10496_11 1 chr1:196658279_C_T rs7529589 trans 1 196658279 T C 0.3912 -0.1214 0.0137 9.12e-19 'Calcium-activated chloride channel regulator 1 ENSG00000016490 'CLCA1 intron_variant 0.998599 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect CLCA1 chr1 86468368 86500259 1 1179 protein_coding 1:196689149 110220781 30_1_7 SeqId_10527_22 'DHX9 chr1:196664255_G_T$SeqId_10527_22 1 chr1:196664255_G_T rs12033127 trans 1 196664255 T G 0.3914 0.2495 0.0136 9.39e-75 'ATP-dependent RNA helicase A ENSG00000135829 'DHX9 intron_variant 0.999766 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect DHX9 chr1 182839347 182887982 1 1660 protein_coding 1:196695125 13855778 30_1_7 SeqId_10531_18 'RASN chr1:196656205_A_T$SeqId_10531_18 1 chr1:196656205_A_T rs1329421 trans 1 196656205 A T 0.3913 -0.0912 0.0133 7.04e-12 'GTPase NRas ENSG00000213281 'NRAS intron_variant 0.998833 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect NRAS chr1 114704469 114716771 -1 4893 protein_coding 1:196687075 81970304 30_1_7 SeqId_10561_5 'PGRP-I-alpha chr1:196668360_D_I$SeqId_10561_5 1 chr1:196668360_D_I rs34813609 trans 1 196668360 D I 0.6095 -0.1382 0.0137 5.91e-24 'Peptidoglycan recognition protein 3 ENSG00000159527 'PGLYRP3 intron_variant 0.998117 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect PGLYRP3 chr1 153297116 153312952 -1 114771 protein_coding 1:196699231 43386279 30_1_7 SeqId_10637_50 'K1324 chr1:196661838_D_I$SeqId_10637_50 1 chr1:196661838_D_I rs61229706 trans 1 196661838 D I 0.6193 0.1051 0.0133 3.34e-15 'UPF0577 protein KIAA1324 ENSG00000116299 'KIAA1324 intron_variant 0.959503 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect ELAPOR1 chr1 109113679 109206781 1 57535 protein_coding 1:196692709 87579030 30_1_7 SeqId_10643_16 'NOE3 chr1:196668360_D_I$SeqId_10643_16 1 chr1:196668360_D_I rs34813609 trans 1 196668360 D I 0.6095 -0.1449 0.0136 2.02e-26 'Noelin-3 ENSG00000118733 'OLFM3 intron_variant 0.998117 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect OLFM3 chr1 101802560 101996926 -1 118427 protein_coding 1:196699231 94702305 30_1_7 SeqId_10667_78 'CA185 chr1:196646261_A_G$SeqId_10667_78 1 chr1:196646261_A_G rs572515 trans 1 196646261 A G 0.3897 -0.1267 0.0143 8.28e-19 'Uncharacterized protein C1orf185 ENSG00000204006 'C1orf185 intron_variant 0.995105 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect C1orf185 chr1 51102221 51148086 1 284546 protein_coding 1:196677131 145574910 30_1_7 SeqId_10705_14 'SIA7C chr1:196672385_A_G$SeqId_10705_14 1 chr1:196672385_A_G rs203688 trans 1 196672385 A G 0.6089 0.1624 0.0137 2.46e-32 'Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 ENSG00000184005 'ST6GALNAC3 intron_variant 0.989272 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect ST6GALNAC3 chr1 76074746 76634603 1 256435 protein_coding 1:196703255 120628509 30_1_7 SeqId_10814_7 'CD1A chr1:196668360_D_I$SeqId_10814_7 1 chr1:196668360_D_I rs34813609 trans 1 196668360 D I 0.6095 -0.2966 0.0135 6.04e-107 'T-cell surface glycoprotein CD1a ENSG00000158477 'CD1A intron_variant 0.998117 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect CD1A chr1 158254424 158258269 1 909 protein_coding 1:196699231 38444807 30_1_7 SeqId_17325_10 'KGUA chr1:196660261_A_G$SeqId_17325_10 1 chr1:196660261_A_G rs10801555 trans 1 196660261 A G 0.3911 -0.1102 0.0139 2.31e-15 'Guanylate kinase ENSG00000143774 'GUK1 intron_variant 0.998132 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect GUK1 chr1 228139962 228148984 1 2987 protein_coding 1:196691131 31448831 30_1_7 SeqId_10830_5 'K0494 chr1:196664255_G_T$SeqId_10830_5 1 chr1:196664255_G_T rs12033127 trans 1 196664255 T G 0.3914 -0.0936 0.0137 1.0e-11 'EF-hand calcium-binding domain-containing protein 14 ENSG00000159658 'EFCAB14 intron_variant 0.999766 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect EFCAB14 chr1 46674659 46719146 -1 9813 protein_coding 1:196695125 149975979 30_1_7 SeqId_11186_12 'TMM52 chr1:196665041_A_G$SeqId_11186_12 1 chr1:196665041_A_G rs10922099 trans 1 196665041 A G 0.6099 0.1054 0.0138 2.54e-14 'Transmembrane protein 52 ENSG00000178821 'TMEM52 intron_variant 0.995803 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect TMEM52 chr1 1917590 1919279 -1 339456 protein_coding 1:196695911 194776632 30_1_7 SeqId_11308_8 'CR3L4 chr1:196664651_C_T$SeqId_11308_8 1 chr1:196664651_C_T rs10922098 trans 1 196664651 T C 0.6073 0.1044 0.0136 1.51e-14 'Cyclic AMP-responsive element-binding protein 3-like protein 4 ENSG00000143578 'CREB3L4 intron_variant 0.999296 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect CREB3L4 chr1 153967534 153974361 1 148327 protein_coding 1:196695521 42727987 30_1_7 SeqId_11325_8 'BTG2 chr1:196665208_A_G$SeqId_11325_8 1 chr1:196665208_A_G rs10922100 trans 1 196665208 A G 0.3913 0.3766 0.0133 3.72e-175 'Protein BTG2 ENSG00000159388 'BTG2 intron_variant 1.0 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect BTG2 chr1 203305491 203309602 1 7832 protein_coding 1:196696078 6609413 30_1_7 SeqId_11327_56 'CLK2 chr1:196668360_D_I$SeqId_11327_56 1 chr1:196668360_D_I rs34813609 trans 1 196668360 D I 0.6095 -0.3574 0.0132 1.73e-160 'Dual specificity protein kinase CLK2 ENSG00000176444 'CLK2 intron_variant 0.998117 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect CLK2 chr1 155262868 155278491 -1 1196 protein_coding 1:196699231 41420740 30_1_7 SeqId_11536_9 'MYSM1 chr1:196660261_A_G$SeqId_11536_9 1 chr1:196660261_A_G rs10801555 trans 1 196660261 A G 0.3911 -0.0988 0.014 1.41e-12 'Histone H2A deubiquitinase MYSM1 ENSG00000162601 'MYSM1 intron_variant 0.998132 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect MYSM1 chr1 58643440 58700077 -1 114803 protein_coding 1:196691131 137991054 30_1_7 SeqId_11653_69 'SC6A9 chr1:196664651_C_T$SeqId_11653_69 1 chr1:196664651_C_T rs10922098 trans 1 196664651 T C 0.6073 0.1021 0.0133 1.58e-14 'Sodium- and chloride-dependent glycine transporter 1 ENSG00000196517 'SLC6A9 intron_variant 0.999296 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect SLC6A9 chr1 43991500 44031467 -1 6536 protein_coding 1:196695521 152664054 30_1_7 SeqId_11682_7 'TXNIP chr1:196668360_D_I$SeqId_11682_7 1 chr1:196668360_D_I rs34813609 trans 1 196668360 D I 0.6095 -0.3021 0.0135 1.98e-110 'Thioredoxin-interacting protein ENSG00000117289 'TXNIP intron_variant 0.998117 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect TXNIP chr1 145992435 145996579 -1 10628 protein_coding 1:196699231 50702652 30_1_7 SeqId_11696_7 'RABP2 chr1:196671118_A_G$SeqId_11696_7 1 chr1:196671118_A_G rs10922103 trans 1 196671118 A G 0.6077 0.0976 0.0131 1.07e-13 'Cellular retinoic acid-binding protein 2 ENSG00000143320 'CRABP2 intron_variant 0.994172 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect CRABP2 chr1 156699606 156705816 -1 1382 protein_coding 1:196701988 39996172 30_1_7 SeqId_12046_51 'TADBP chr1:196664651_C_T$SeqId_12046_51 1 chr1:196664651_C_T rs10922098 trans 1 196664651 T C 0.6073 -0.1155 0.0136 2.51e-17 'TAR DNA-binding protein 43 ENSG00000120948 'TARDBP intron_variant 0.999296 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect TARDBP chr1 11012344 11030528 1 23435 protein_coding 1:196695521 185683177 30_1_7 SeqId_12329_21 'KS6A1 chr1:196655743_A_C$SeqId_12329_21 1 chr1:196655743_A_C rs10801553 trans 1 196655743 A C 0.3909 0.9934 0.0095 2.98e-2377 'Ribosomal protein S6 kinase alpha-1 ENSG00000117676 'RPS6KA1 intron_variant 0.999066 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect RPS6KA1 chr1 26529761 26575030 1 6195 protein_coding 1:196686613 170156852 30_1_7 SeqId_18840_205 'SH21B chr1:196672385_A_G$SeqId_18840_205 1 chr1:196672385_A_G rs203688 trans 1 196672385 A G 0.609 -0.1282 0.0135 2.93e-21 'SH2 domain-containing protein 1B ENSG00000198574 'SH2D1B intron_variant 0.989272 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect SH2D1B chr1 162395268 162412138 -1 117157 protein_coding 1:196703255 34291117 30_1_7 SeqId_12400_25 'UBE2T chr1:196671666_D_I$SeqId_12400_25 1 chr1:196671666_D_I rs201263987 trans 1 196671666 D I 0.6106 -0.1363 0.0138 4.05e-23 'Ubiquitin-conjugating enzyme E2 T ENSG00000077152 'UBE2T intron_variant 0.986979 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect UBE2T chr1 202331657 202341980 -1 29089 protein_coding 1:196702537 5639443 30_1_7 SeqId_12406_119 'ARHI chr1:196665208_A_G$SeqId_12406_119 1 chr1:196665208_A_G rs10922100 trans 1 196665208 A G 0.3913 -0.1449 0.0136 2.12e-26 'GTP-binding protein Di-Ras3 ENSG00000162595 'DIRAS3 intron_variant 1.0 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect DIRAS3 chr1 68045886 68051717 -1 9077 protein_coding 1:196696078 128644361 30_1_7 SeqId_12409_90 'RAB7B chr1:196672385_A_G$SeqId_12409_90 1 chr1:196672385_A_G rs203688 none 1 196672385 A G 0.6089 0.1042 0.0136 1.88e-14 'Ras-related protein Rab-7b intron_variant 0.989272 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect RAB7B chr1 205976740 206003461 -1 338382 protein_coding 1:196703255 9300206 30_1_7 SeqId_12444_39 'NR5A2 chr1:196661838_D_I$SeqId_12444_39 1 chr1:196661838_D_I rs61229706 trans 1 196661838 D I 0.6194 0.1258 0.0139 1.8e-19 'Nuclear receptor subfamily 5 group A member 2 ENSG00000116833 'NR5A2 intron_variant 0.959503 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect NR5A2 chr1 200027614 200177420 1 2494 protein_coding 1:196692709 3334905 30_1_7 SeqId_12504_26 'LMOD1 chr1:196660261_A_G$SeqId_12504_26 1 chr1:196660261_A_G rs10801555 trans 1 196660261 A G 0.3911 0.1296 0.0144 2.89e-19 'Leiomodin-1 ENSG00000163431 'LMOD1 intron_variant 0.998132 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect LMOD1 chr1 201896456 201946588 -1 25802 protein_coding 1:196691131 5255457 30_1_7 SeqId_12521_3 'CDN2C chr1:196668360_D_I$SeqId_12521_3 1 chr1:196668360_D_I rs34813609 trans 1 196668360 D I 0.6095 -0.3175 0.0134 2.12e-124 'Cyclin-dependent kinase 4 inhibitor C ENSG00000123080 'CDKN2C intron_variant 0.998117 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect CDKN2C chr1 50960745 50974634 1 1031 protein_coding 1:196699231 145738486 30_1_7 SeqId_12548_75 'RRAGC chr1:196661838_D_I$SeqId_12548_75 1 chr1:196661838_D_I rs61229706 trans 1 196661838 D I 0.6194 0.1189 0.0141 3.9e-17 'Ras-related GTP-binding protein C ENSG00000116954 'RRAGC intron_variant 0.959503 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect RRAGC chr1 38838198 38859772 -1 64121 protein_coding 1:196692709 157832937 30_1_7 SeqId_12603_87 'PABP4 chr1:196646176_G_T$SeqId_12603_87 1 chr1:196646176_G_T rs1329424 trans 1 196646176 T G 0.3901 -0.0942 0.0131 6.18e-13 'Polyadenylate-binding protein 4 ENSG00000090621 'PABPC4 intron_variant 0.986946 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect PABPC4 chr1 39560709 39576790 -1 8761 protein_coding 1:196677046 157100256 30_1_7 SeqId_12604_16 'SCMH1 chr1:196671986_A_G$SeqId_12604_16 1 chr1:196671986_A_G rs402056 trans 1 196671986 A G 0.6091 -0.2723 0.0134 1.33e-91 'Polycomb protein SCMH1 ENSG00000010803 'SCMH1 intron_variant 0.98996 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect SCMH1 chr1 41027200 41242154 -1 22955 protein_coding 1:196702856 155460702 30_1_7 SeqId_12622_96 'ASH1L chr1:196672473_C_T$SeqId_12622_96 1 chr1:196672473_C_T rs12045503 trans 1 196672473 T C 0.6078 0.0967 0.0138 2.68e-12 'Histone-lysine N-methyltransferase ASH1L ENSG00000116539 'ASH1L intron_variant 0.994169 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect ASH1L chr1 155335268 155563162 -1 55870 protein_coding 1:196703343 41140181 30_1_7 SeqId_12695_62 'KLH12 chr1:196660261_A_G$SeqId_12695_62 1 chr1:196660261_A_G rs10801555 trans 1 196660261 A G 0.3911 -0.1219 0.0143 1.56e-17 'Kelch-like protein 12 ENSG00000117153 'KLHL12 intron_variant 0.998132 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect KLHL12 chr1 202891116 202928636 -1 59349 protein_coding 1:196691131 6237505 30_1_7 SeqId_12880_1 'SV2A chr1:196646176_G_T$SeqId_12880_1 1 chr1:196646176_G_T rs1329424 trans 1 196646176 T G 0.3901 -0.0994 0.0133 9.75e-14 'Synaptic vesicle glycoprotein 2A ENSG00000159164 'SV2A intron_variant 0.986946 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect SV2A chr1 149903318 149917844 -1 9900 protein_coding 1:196677046 46759202 30_1_7 SeqId_12892_10 'SYTL1 chr1:196671118_A_G$SeqId_12892_10 1 chr1:196671118_A_G rs10922103 trans 1 196671118 A G 0.6078 -0.1324 0.0138 9.9e-22 'Synaptotagmin-like protein 1 ENSG00000142765 'SYTL1 intron_variant 0.994172 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect SYTL1 chr1 27342020 27353937 1 84958 protein_coding 1:196701988 169359968 30_1_7 SeqId_13042_7 'KCA10 chr1:196664651_C_T$SeqId_13042_7 1 chr1:196664651_C_T rs10922098 trans 1 196664651 T C 0.6073 -0.1434 0.0135 2.08e-26 'Potassium voltage-gated channel subfamily A member 10 ENSG00000143105 'KCNA10 intron_variant 0.999296 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect KCNA10 chr1 110517217 110519175 -1 3744 protein_coding 1:196695521 86176346 30_1_7 SeqId_13109_82 'NEGR1 chr1:196660261_A_G$SeqId_13109_82 1 chr1:196660261_A_G rs10801555 trans 1 196660261 A G 0.3911 0.1027 0.0142 5.08e-13 'Neuronal growth regulator 1 ENSG00000172260 'NEGR1 intron_variant 0.998132 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect NEGR1 chr1 71395943 72282539 -1 257194 protein_coding 1:196691131 124408592 30_1_7 SeqId_13377_3 'C56D1 chr1:196671666_D_I$SeqId_13377_3 1 chr1:196671666_D_I rs201263987 trans 1 196671666 D I 0.6106 -0.1488 0.0133 7.46e-29 'Cytochrome b561 domain-containing protein 1 ENSG00000174151 'CYB561D1 intron_variant 0.986979 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect CYB561D1 chr1 109494052 109502932 1 284613 protein_coding 1:196702537 87208485 30_1_7 SeqId_13449_25 'SF3B4 chr1:196671118_A_G$SeqId_13449_25 1 chr1:196671118_A_G rs10922103 trans 1 196671118 A G 0.6077 0.1097 0.0136 9.32e-16 'Splicing factor 3B subunit 4 ENSG00000143368 'SF3B4 intron_variant 0.994172 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect SF3B4 chr1 149923317 149927803 -1 10262 protein_coding 1:196701988 46774185 30_1_7 SeqId_13561_5 '5HT6R chr1:196661730_D_I$SeqId_13561_5 1 chr1:196661730_D_I 1:196661730_D_I trans 1 196661730 D I 0.3865 -0.255 0.0138 3.02e-76 '5-hydroxytryptamine receptor 6 ENSG00000158748 'HTR6 intron_variant 0.992323 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect HTR6 chr1 19664875 19680966 1 3362 protein_coding 1:196692600 177027725 30_1_7 SeqId_13613_23 'Adenylate kinase isoenzyme 5 chr1:196671118_A_G$SeqId_13613_23 1 chr1:196671118_A_G rs10922103 trans 1 196671118 A G 0.6078 -0.1059 0.0138 1.84e-14 'Adenylate kinase isoenzyme 5 ENSG00000154027 'AK5 intron_variant 0.994172 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect AK5 chr1 77282019 77559966 1 26289 protein_coding 1:196701988 119419969 30_1_7 SeqId_13624_17 'NADK chr1:196668360_D_I$SeqId_13624_17 1 chr1:196668360_D_I rs34813609 trans 1 196668360 D I 0.6095 0.117 0.0138 2.59e-17 'NAD kinase ENSG00000008130 'NADK intron_variant 0.998117 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect NADK chr1 1751232 1780457 -1 65220 protein_coding 1:196699231 194918774 30_1_7 SeqId_13672_3 'HSP76 chr1:196668360_D_I$SeqId_13672_3 1 chr1:196668360_D_I rs34813609 trans 1 196668360 D I 0.6095 -0.2554 0.0136 9.82e-79 'Heat shock 70 kDa protein 6 ENSG00000173110 'HSPA6 intron_variant 0.998117 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect HSPA6 chr1 161524540 161526894 1 3310 protein_coding 1:196699231 35174691 30_1_7 SeqId_13698_28 'K319L chr1:196670757_C_T$SeqId_13698_28 1 chr1:196670757_C_T rs4658046 trans 1 196670757 T C 0.6076 -0.1034 0.0131 2.5e-15 'Dyslexia-associated protein KIAA0319-like protein ENSG00000142687 'KIAA0319L intron_variant 0.99417 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect KIAA0319L chr1 35433492 35557950 -1 79932 protein_coding 1:196701627 161143677 30_1_7 SeqId_13966_30 'MYOM3 chr1:196666044_C_T$SeqId_13966_30 1 chr1:196666044_C_T rs76258507 trans 1 196666044 T C 0.3913 0.2897 0.0133 1.79e-105 'Myomesin-3 ENSG00000142661 'MYOM3 intron_variant 0.999298 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect MYOM3 chr1 24056035 24112135 -1 127294 protein_coding 1:196696914 172584779 30_1_7 SeqId_14025_18 '4-1BB chr1:196661838_D_I$SeqId_14025_18 1 chr1:196661838_D_I rs61229706 trans 1 196661838 D I 0.6195 0.1083 0.0141 1.27e-14 'Tumor necrosis factor receptor superfamily member 9 ENSG00000049249 'TNFRSF9 intron_variant 0.959503 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect TNFRSF9 chr1 7915871 7943165 -1 3604 protein_coding 1:196692709 188749544 30_1_7 SeqId_14208_3 'RET7 chr1:196668360_D_I$SeqId_14208_3 1 chr1:196668360_D_I rs34813609 trans 1 196668360 D I 0.6095 -0.2391 0.0135 1.16e-69 'Retinoid-binding protein 7 ENSG00000162444 'RBP7 intron_variant 0.998117 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect RBP7 chr1 9997206 10016021 1 116362 protein_coding 1:196699231 186702025 30_1_7 SeqId_14245_195 'SNX7 chr1:196664651_C_T$SeqId_14245_195 1 chr1:196664651_C_T rs10922098 trans 1 196664651 T C 0.6073 -0.2354 0.0136 4.68e-67 'Sorting nexin-7 ENSG00000162627 'SNX7 intron_variant 0.999296 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect SNX7 chr1 98661701 98760500 1 51375 protein_coding 1:196695521 98033820 30_1_7 SeqId_14597_5 'SEM6C chr1:196652124_D_I$SeqId_14597_5 1 chr1:196652124_D_I rs33944729 trans 1 196652124 D I 0.3888 -0.1348 0.0138 1.88e-22 'Semaphorin-6C ENSG00000143434 'SEMA6C intron_variant 0.991562 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect SEMA6C chr1 151131685 151146631 -1 10500 protein_coding 1:196682995 45536364 30_1_7 SeqId_14603_51 'KIAA0040 chr1:196646176_G_T$SeqId_14603_51 1 chr1:196646176_G_T rs1329424 trans 1 196646176 T G 0.39 -0.1296 0.013 2.27e-23 'Uncharacterized protein KIAA0040 ENSG00000235750 'KIAA0040 intron_variant 0.986946 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect KIAA0040 chr1 175156986 175192999 -1 9674 protein_coding 1:196677046 21484047 30_1_7 SeqId_15318_75 'Calpactin I light chain chr1:196646176_G_T$SeqId_15318_75 1 chr1:196646176_G_T rs1329424 trans 1 196646176 T G 0.39 0.093 0.0134 4.0e-12 'Protein S100-A10 ENSG00000197747 'S100A10 intron_variant 0.986946 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect S100A10 chr1 151982915 151993859 -1 6281 protein_coding 1:196677046 44683187 30_1_7 SeqId_15529_33 'Cysteine-rich protein 1 chr1:196646176_G_T$SeqId_15529_33 1 chr1:196646176_G_T rs1329424 trans 1 196646176 T G 0.3901 -0.1043 0.0136 1.75e-14 'Cysteine and glycine-rich protein 1 ENSG00000159176 'CSRP1 intron_variant 0.986946 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect CSRP1 chr1 201483530 201509456 -1 1465 protein_coding 1:196677046 4832410 30_1_7 SeqId_15583_18 'FCRLB chr1:196652124_D_I$SeqId_15583_18 1 chr1:196652124_D_I rs33944729 trans 1 196652124 D I 0.3888 -0.1308 0.0139 4.27e-21 'Fc receptor-like B ENSG00000162746 'FCRLB intron_variant 0.991562 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect FCRLB chr1 161721563 161728143 1 127943 protein_coding 1:196682995 34961432 30_1_7 SeqId_15668_19 'BMP-8 chr1:196668287_C_T$SeqId_15668_19 1 chr1:196668287_C_T rs10922102 trans 1 196668287 T C 0.6087 -0.3543 0.013 2.56e-162 'Bone morphogenetic protein 8B ENSG00000116985 'BMP8B intron_variant 1.0 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect BMP8B chr1 39757182 39788865 -1 656 protein_coding 1:196699157 156910292 30_1_7 SeqId_4359_87 'DYRK3 chr1:196668360_D_I$SeqId_4359_87 1 chr1:196668360_D_I rs34813609 trans 1 196668360 D I 0.6095 -0.267 0.0136 1.74e-85 'Dual specificity tyrosine-phosphorylation-regulated kinase 3 ENSG00000143479 'DYRK3 intron_variant 0.998117 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect DYRK3 chr1 206635536 206684419 1 8444 protein_coding 1:196699231 9936305 30_1_7 SeqId_16591_71 'CHIA chr1:196672385_A_G$SeqId_16591_71 1 chr1:196672385_A_G rs203688 trans 1 196672385 A G 0.6089 -0.1545 0.0134 1.53e-30 'Acidic mammalian chitinase ENSG00000134216 'CHIA intron_variant 0.989272 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect CHIA chr1 111290851 111320566 1 27159 protein_coding 1:196703255 85412404 30_1_7 SeqId_16612_28 'SDC3 chr1:196668360_D_I$SeqId_16612_28 1 chr1:196668360_D_I rs34813609 trans 1 196668360 D I 0.6095 -0.248 0.0134 1.39e-76 'Syndecan-3 ENSG00000162512 'SDC3 intron_variant 0.998117 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect SDC3 chr1 30869466 30908758 -1 9672 protein_coding 1:196699231 165790473 30_1_7 SeqId_16845_15 'MPZL1 chr1:196664651_C_T$SeqId_16845_15 1 chr1:196664651_C_T rs10922098 trans 1 196664651 T C 0.6073 0.1624 0.0137 2.68e-32 'Myelin protein zero-like protein 1 ENSG00000197965 'MPZL1 intron_variant 0.999296 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect MPZL1 chr1 167721192 167791919 1 9019 protein_coding 1:196695521 28974329 30_1_7 SeqId_16850_5 'RGS5 chr1:196670839_A_G$SeqId_16850_5 1 chr1:196670839_A_G rs10754199 trans 1 196670839 A G 0.3919 0.1715 0.0141 4.8e-34 'Regulator of G-protein signaling 5 ENSG00000143248 'RGS5 intron_variant 0.994172 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect RGS5 chr1 163111121 163321791 -1 8490 protein_coding 1:196701709 33379918 30_1_7 SeqId_16852_10 'NHRF3 chr1:196664651_C_T$SeqId_16852_10 1 chr1:196664651_C_T rs10922098 trans 1 196664651 T C 0.6073 -0.1757 0.0134 4.53e-39 'Na(+)/H(+) exchange regulatory cofactor NHE-RF3 ENSG00000174827 'PDZK1 intron_variant 0.999296 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect PDZK1 chr1 145670852 145708148 -1 5174 protein_coding 1:196695521 50987373 30_1_7 SeqId_17332_3 'ARHL2 chr1:196646176_G_T$SeqId_17332_3 1 chr1:196646176_G_T rs1329424 trans 1 196646176 T G 0.3901 -0.109 0.0129 3.64e-17 'Poly(ADP-ribose) glycohydrolase ARH3 ENSG00000116863 'ADPRHL2 intron_variant 0.986946 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect ADPRS chr1 36088892 36093932 1 54936 protein_coding 1:196677046 160588154 30_1_7 SeqId_17347_80 'CA080 chr1:196646176_G_T$SeqId_17347_80 1 chr1:196646176_G_T rs1329424 trans 1 196646176 T G 0.3901 -0.0987 0.0135 2.87e-13 'Axin interactor, dorsalization-associated protein ENSG00000186063 'AIDA intron_variant 0.986946 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect AIDA chr1 222668013 222713210 -1 64853 protein_coding 1:196677046 26036164 30_1_7 SeqId_17432_25 'KAD4 chr1:196665208_A_G$SeqId_17432_25 1 chr1:196665208_A_G rs10922100 trans 1 196665208 A G 0.3913 0.1558 0.0137 8.66e-30 'Adenylate kinase 4, mitochondrial ENSG00000162433 'AK4 intron_variant 1.0 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect AK4 chr1 65147549 65232145 1 205 protein_coding 1:196696078 131548529 30_1_7 SeqId_17814_8 'BPNT1 chr1:196672473_C_T$SeqId_17814_8 1 chr1:196672473_C_T rs12045503 trans 1 196672473 T C 0.6078 0.0903 0.013 4.43e-12 '3'(2'),5'-bisphosphate nucleotidase 1 ENSG00000162813 'BPNT1 intron_variant 0.994169 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect BPNT1 chr1 220057482 220090462 -1 10380 protein_coding 1:196703343 23387119 30_1_7 SeqId_17828_3 'S100A14 chr1:196661838_D_I$SeqId_17828_3 1 chr1:196661838_D_I rs61229706 trans 1 196661838 D I 0.6194 0.1277 0.0142 2.33e-19 'Protein S100-A14 ENSG00000189334 'S100A14 intron_variant 0.959503 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect S100A14 chr1 153614255 153616986 -1 57402 protein_coding 1:196692709 43075723 30_1_7 SeqId_17855_28 'RGS4 chr1:196666044_C_T$SeqId_17855_28 1 chr1:196666044_C_T rs76258507 trans 1 196666044 T C 0.3913 0.2014 0.0136 2.6e-49 'Regulator of G-protein signaling 4 ENSG00000117152 'RGS4 intron_variant 0.999298 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect RGS4 chr1 163068775 163076802 1 5999 protein_coding 1:196696914 33628139 30_1_7 SeqId_18255_6 'NB5R1 chr1:196776407_A_G$SeqId_18255_6 1 chr1:196776407_A_G rs448757 trans 1 196776407 A G 0.4921 -0.1155 0.0139 1.24e-16 'NADH-cytochrome b5 reductase 1 ENSG00000159348 'CYB5R1 intergenic_variant 0.714082 rs425757 ENSG00000244414 'CFHR1 missense_variant none ENSG00000000971 'CFH 3 known unspecific_effect CYB5R1 chr1 202961873 202967275 -1 51706 protein_coding 1:196807277 6159998 30_1_7 SeqId_18328_36 'P5CR2 chr1:196664651_C_T$SeqId_18328_36 1 chr1:196664651_C_T rs10922098 trans 1 196664651 T C 0.6073 -0.3009 0.0136 8.08e-109 'Pyrroline-5-carboxylate reductase 2 ENSG00000143811 'PYCR2 intron_variant 0.999296 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect PYCR2 chr1 225919877 225924340 -1 29920 protein_coding 1:196695521 29228819 30_1_7 SeqId_18483_36 'MSS4 chr1:196670839_A_G$SeqId_18483_36 1 chr1:196670839_A_G rs10754199 trans 1 196670839 A G 0.3919 0.1194 0.0145 1.66e-16 'Guanine nucleotide exchange factor MSS4 ENSG00000183155 'RABIF intron_variant 0.994172 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect RABIF chr1 202878282 202889149 -1 5877 protein_coding 1:196701709 6187440 30_1_7 SeqId_18830_1 'Omentin chr1:196660261_A_G$SeqId_18830_1 1 chr1:196660261_A_G rs10801555 trans 1 196660261 A G 0.3911 0.124 0.0139 4.16e-19 'Intelectin-1 ENSG00000179914 'ITLN1 intron_variant 0.998132 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect ITLN1 chr1 160876540 160885180 -1 55600 protein_coding 1:196691131 35805951 30_1_7 SeqId_6020_52 'Urotensin-II chr1:196663016_A_G$SeqId_6020_52 1 chr1:196663016_A_G rs3645 trans 1 196663016 A G 0.6088 -0.4034 0.0132 1.33e-203 'Urotensin-2 ENSG00000049247 'UTS2 intron_variant 1.0 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect UTS2 chr1 7843083 7853512 -1 10911 protein_coding 1:196693886 188840374 30_1_7 SeqId_18932_84 'NMNA1 chr1:196671666_D_I$SeqId_18932_84 1 chr1:196671666_D_I rs201263987 trans 1 196671666 D I 0.6106 0.1029 0.0139 1.4e-13 'Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 ENSG00000173614 'NMNAT1 intron_variant 0.986979 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect NMNAT1 chr1 9943428 9985501 1 64802 protein_coding 1:196702537 186759109 30_1_7 SeqId_19264_6 'RFA2 chr1:196646261_A_G$SeqId_19264_6 1 chr1:196646261_A_G rs572515 trans 1 196646261 A G 0.3897 0.1094 0.0145 4.41e-14 'Replication protein A 32 kDa subunit ENSG00000117748 'RPA2 intron_variant 0.995105 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect RPA2 chr1 27891524 27914746 -1 6118 protein_coding 1:196677131 168762385 30_1_7 SeqId_19270_26 'SYYC chr1:196672473_C_T$SeqId_19270_26 1 chr1:196672473_C_T rs12045503 trans 1 196672473 T C 0.6078 0.0979 0.0134 2.4e-13 'Tyrosine--tRNA ligase, cytoplasmic ENSG00000134684 'YARS intron_variant 0.994169 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect YARS1 chr1 32775237 32817380 -1 8565 protein_coding 1:196703343 163885963 30_1_7 SeqId_19282_3 'RAB13 chr1:196672473_C_T$SeqId_19282_3 1 chr1:196672473_C_T rs12045503 trans 1 196672473 T C 0.6078 0.0936 0.0133 2.18e-12 'Ras-related protein Rab-13 ENSG00000143545 'RAB13 intron_variant 0.994169 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect RAB13 chr1 153981617 153986358 -1 5872 protein_coding 1:196703343 42716985 30_1_7 SeqId_19341_36 'ACBD6 chr1:196672473_C_T$SeqId_19341_36 1 chr1:196672473_C_T rs12045503 trans 1 196672473 T C 0.6078 0.1339 0.0135 3.3e-23 'Acyl-CoA-binding domain-containing protein 6 ENSG00000135847 'ACBD6 intron_variant 0.994169 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect ACBD6 chr1 180269653 180502954 -1 84320 protein_coding 1:196703343 16200389 30_1_7 SeqId_2449_1 'GV chr1:196671666_D_I$SeqId_2449_1 1 chr1:196671666_D_I rs201263987 trans 1 196671666 D I 0.6105 0.1157 0.0131 1.03e-18 'Calcium-dependent phospholipase A2 ENSG00000127472 'PLA2G5 intron_variant 0.986979 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect PLA2G5 chr1 20028179 20091911 1 5322 protein_coding 1:196702537 176674358 30_1_7 SeqId_2605_49 'CD30 chr1:196665208_A_G$SeqId_2605_49 1 chr1:196665208_A_G rs10922100 trans 1 196665208 A G 0.3913 0.2091 0.0136 3.9e-53 'Tumor necrosis factor receptor superfamily member 8 ENSG00000120949 'TNFRSF8 intron_variant 1.0 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect TNFRSF8 chr1 12063303 12144207 1 943 protein_coding 1:196696078 184632775 30_1_7 SeqId_2708_54 'TNFSF18 chr1:196664255_G_T$SeqId_2708_54 1 chr1:196664255_G_T rs12033127 trans 1 196664255 T G 0.3914 0.2571 0.0136 1.54e-79 'Tumor necrosis factor ligand superfamily member 18 ENSG00000120337 'TNFSF18 intron_variant 0.999766 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect TNFSF18 chr1 173039202 173050941 -1 8995 protein_coding 1:196695125 23644184 30_1_7 SeqId_2809_25 'ADAMTS-4 chr1:196670839_A_G$SeqId_2809_25 1 chr1:196670839_A_G rs10754199 trans 1 196670839 A G 0.3919 -0.1243 0.0145 9.05e-18 'A disintegrin and metalloproteinase with thrombospondin motifs 4 ENSG00000158859 'ADAMTS4 intron_variant 0.994172 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect ADAMTS4 chr1 161184302 161199054 -1 9507 protein_coding 1:196701709 35502655 30_1_7 SeqId_7192_37 'CRF2-12 chr1:196672473_C_T$SeqId_7192_37 1 chr1:196672473_C_T rs12045503 trans 1 196672473 T C 0.6078 0.1074 0.0133 8.0e-16 'Interferon lambda receptor 1 ENSG00000185436 'IFNLR1 intron_variant 0.994169 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect IFNLR1 chr1 24154168 24187959 -1 163702 protein_coding 1:196703343 172515384 30_1_7 SeqId_2967_8 'VCAM-1 chr1:196652124_D_I$SeqId_2967_8 1 chr1:196652124_D_I rs33944729 trans 1 196652124 D I 0.3888 0.1059 0.0137 1.29e-14 'Vascular cell adhesion protein 1 ENSG00000162692 'VCAM1 intron_variant 0.991562 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect VCAM1 chr1 100719742 100739045 1 7412 protein_coding 1:196682995 95963253 30_1_7 SeqId_7732_45 'VAMP4 chr1:196661838_D_I$SeqId_7732_45 1 chr1:196661838_D_I rs61229706 trans 1 196661838 D I 0.6195 0.0992 0.0142 2.65e-12 'Vesicle-associated membrane protein 4 ENSG00000117533 'VAMP4 intron_variant 0.959503 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect VAMP4 chr1 171700160 171742074 -1 8674 protein_coding 1:196692709 24950635 30_1_7 SeqId_3323_37 'LRP8 chr1:196658279_C_T$SeqId_3323_37 1 chr1:196658279_C_T rs7529589 trans 1 196658279 T C 0.3912 -0.1 0.0136 2.17e-13 'Low-density lipoprotein receptor-related protein 8 ENSG00000157193 'LRP8 intron_variant 0.998599 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect LRP8 chr1 53242364 53328469 -1 7804 protein_coding 1:196689149 143360680 30_1_7 SeqId_8272_22 'DHB7 chr1:196672385_A_G$SeqId_8272_22 1 chr1:196672385_A_G rs203688 trans 1 196672385 A G 0.609 0.1553 0.0138 2.42e-29 '3-keto-steroid reductase ENSG00000132196 'HSD17B7 intron_variant 0.989272 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect HSD17B7 chr1 162790702 162812823 1 51478 protein_coding 1:196703255 33912553 30_1_7 SeqId_3405_6 'UFC1 chr1:196670839_A_G$SeqId_3405_6 1 chr1:196670839_A_G rs10754199 trans 1 196670839 A G 0.3919 -0.1001 0.0139 4.88e-13 'Ubiquitin-fold modifier-conjugating enzyme 1 ENSG00000143222 'UFC1 intron_variant 0.994172 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect UFC1 chr1 161152776 161158856 1 51506 protein_coding 1:196701709 35548933 30_1_7 SeqId_3461_58 'PGCB chr1:196670839_A_G$SeqId_3461_58 1 chr1:196670839_A_G rs10754199 trans 1 196670839 A G 0.3919 -0.1001 0.0143 2.19e-12 'Brevican core protein ENSG00000132692 'BCAN intron_variant 0.994172 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect BCAN chr1 156641390 156659532 1 63827 protein_coding 1:196701709 40060319 30_1_7 SeqId_8520_8 'ADA30 chr1:196660995_A_T$SeqId_8520_8 1 chr1:196660995_A_T rs528298 trans 1 196660995 A T 0.3901 -0.1253 0.0136 4.28e-20 'Disintegrin and metalloproteinase domain-containing protein 30 ENSG00000134249 'ADAM30 intron_variant 0.995803 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect ADAM30 chr1 119893533 119896515 -1 11085 protein_coding 1:196691865 76795350 30_1_7 SeqId_3723_1 'BNP-32 chr1:196671666_D_I$SeqId_3723_1 1 chr1:196671666_D_I rs201263987 trans 1 196671666 D I 0.6106 0.0892 0.013 7.61e-12 'Brain natriuretic peptide 32 ENSG00000120937 'NPPB intron_variant 0.986979 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect NPPB chr1 11857464 11858945 -1 4879 protein_coding 1:196702537 184843592 30_1_7 SeqId_3855_56 'Peroxiredoxin-1 chr1:196670839_A_G$SeqId_3855_56 1 chr1:196670839_A_G rs10754199 trans 1 196670839 A G 0.3919 -0.0972 0.0143 9.85e-12 'Peroxiredoxin-1 ENSG00000117450 'PRDX1 intron_variant 0.994172 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect PRDX1 chr1 45510914 45542732 -1 5052 protein_coding 1:196701709 151158977 30_1_7 SeqId_4156_74 'TGF-b2 chr1:196661838_D_I$SeqId_4156_74 1 chr1:196661838_D_I rs61229706 trans 1 196661838 D I 0.6194 0.1159 0.0137 2.52e-17 'Transforming growth factor beta-2 ENSG00000092969 'TGFB2 intron_variant 0.959503 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect TGFB2 chr1 218345336 218444619 1 7042 protein_coding 1:196692709 21652627 30_1_7 SeqId_9176_3 'MUC1 chr1:196664651_C_T$SeqId_9176_3 1 chr1:196664651_C_T rs10922098 trans 1 196664651 T C 0.6073 -0.289 0.0134 1.42e-102 'Mucin-1 ENSG00000185499 'MUC1 intron_variant 0.999296 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect MUC1 chr1 155185824 155192916 -1 4582 protein_coding 1:196695521 41502605 30_1_7 SeqId_4829_43 'STRATIFIN chr1:196671118_A_G$SeqId_4829_43 1 chr1:196671118_A_G rs10922103 trans 1 196671118 A G 0.6077 0.0972 0.0135 5.72e-13 '14-3-3 protein sigma ENSG00000175793 'SFN intron_variant 0.994172 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect SFN chr1 26863149 26864456 1 2810 protein_coding 1:196701988 169838839 30_1_7 SeqId_4931_59 'TF chr1:196661838_D_I$SeqId_4931_59 1 chr1:196661838_D_I rs61229706 trans 1 196661838 D I 0.6194 0.1027 0.0138 1.23e-13 'Tissue Factor ENSG00000117525 'F3 intron_variant 0.959503 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect F3 chr1 94529173 94541759 -1 2152 protein_coding 1:196692709 102150950 30_1_7 SeqId_5076_53 'EPHAA chr1:196661838_D_I$SeqId_5076_53 1 chr1:196661838_D_I rs61229706 trans 1 196661838 D I 0.6194 0.1082 0.0142 2.14e-14 'Ephrin type-A receptor 10 ENSG00000183317 'EPHA10 intron_variant 0.959503 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect EPHA10 chr1 37713880 37765133 -1 284656 protein_coding 1:196692709 158927576 30_1_7 SeqId_5088_175 'IL-23 R chr1:196671666_D_I$SeqId_5088_175 1 chr1:196671666_D_I rs201263987 trans 1 196671666 D I 0.6106 0.1176 0.013 1.61e-19 'Interleukin-23 receptor ENSG00000162594 'IL23R intron_variant 0.986979 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect IL23R chr1 67138907 67259979 1 149233 protein_coding 1:196702537 129563630 30_1_7 SeqId_5106_52 'NOTC2 chr1:196671986_A_G$SeqId_5106_52 1 chr1:196671986_A_G rs402056 trans 1 196671986 A G 0.6091 0.1038 0.0138 4.81e-14 'Neurogenic locus notch homolog protein 2 ENSG00000134250 'NOTCH2 intron_variant 0.98996 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect NOTCH2 chr1 119911553 120100779 -1 4853 protein_coding 1:196702856 76602077 30_1_7 SeqId_5128_53 'SLAF6 chr1:196664255_G_T$SeqId_5128_53 1 chr1:196664255_G_T rs12033127 trans 1 196664255 T G 0.3914 -0.1007 0.0134 5.89e-14 'SLAM family member 6 ENSG00000162739 'SLAMF6 intron_variant 0.999766 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect SLAMF6 chr1 160485030 160523262 -1 114836 protein_coding 1:196695125 36171863 30_1_7 SeqId_5443_62 'ANP chr1:196661838_D_I$SeqId_5443_62 1 chr1:196661838_D_I rs61229706 trans 1 196661838 D I 0.6194 0.1133 0.0138 2.26e-16 'Atrial natriuretic factor ENSG00000175206 'NPPA intron_variant 0.959503 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect NPPA chr1 11845709 11848345 -1 4878 protein_coding 1:196692709 184844364 30_1_7 SeqId_6896_3 'CA162 chr1:196668360_D_I$SeqId_6896_3 1 chr1:196668360_D_I rs34813609 trans 1 196668360 D I 0.6095 -0.2231 0.0132 9.01e-64 'Transmembrane protein C1orf162 ENSG00000143110 'C1orf162 intron_variant 0.998117 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect C1orf162 chr1 111473792 111478512 1 128346 protein_coding 1:196699231 85225439 30_1_7 SeqId_5526_53 'GITR chr1:196670757_C_T$SeqId_5526_53 1 chr1:196670757_C_T rs4658046 trans 1 196670757 T C 0.6076 -0.1073 0.0135 1.93e-15 'Tumor necrosis factor receptor superfamily member 18 ENSG00000186891 'TNFRSF18 intron_variant 0.99417 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect TNFRSF18 chr1 1203508 1206592 -1 8784 protein_coding 1:196701627 195495035 30_1_7 SeqId_9929_16 'DHB7 chr1:196670839_A_G$SeqId_9929_16 1 chr1:196670839_A_G rs10754199 trans 1 196670839 A G 0.3919 -0.1076 0.0144 8.97e-14 '3-keto-steroid reductase ENSG00000132196 'HSD17B7 intron_variant 0.994172 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect HSD17B7 chr1 162790702 162812823 1 51478 protein_coding 1:196701709 33911007 30_1_7 SeqId_5598_3 'GREM2 chr1:196655280_C_G$SeqId_5598_3 1 chr1:196655280_C_G rs1329422 trans 1 196655280 C G 0.3911 -0.0927 0.0128 5.22e-13 'Gremlin-2 ENSG00000180875 'GREM2 intron_variant 0.999066 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect GREM2 chr1 240489573 240612155 -1 64388 protein_coding 1:196686150 43926005 30_1_7 SeqId_6103_70 'FCRL5 chr1:196671118_A_G$SeqId_6103_70 1 chr1:196671118_A_G rs10922103 trans 1 196671118 A G 0.6078 0.0978 0.0137 1.03e-12 'Fc receptor-like protein 5 ENSG00000143297 'FCRL5 intron_variant 0.994172 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect FCRL5 chr1 157513377 157552515 -1 83416 protein_coding 1:196701988 39149473 30_1_7 SeqId_6264_9 'CYR61 chr1:196664651_C_T$SeqId_6264_9 1 chr1:196664651_C_T rs10922098 trans 1 196664651 T C 0.6073 0.1244 0.0137 8.88e-20 'Protein CYR61 ENSG00000142871 'CYR61 intron_variant 0.999296 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect CCN1 chr1 85580761 85584589 1 3491 protein_coding 1:196695521 111114760 30_1_7 SeqId_6273_58 'P3H1 chr1:196661838_D_I$SeqId_6273_58 1 chr1:196661838_D_I rs61229706 trans 1 196661838 D I 0.6194 -0.0984 0.0135 3.49e-13 'Prolyl 3-hydroxylase 1 ENSG00000117385 'LEPRE1 intron_variant 0.959503 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect P3H1 chr1 42746335 42767084 -1 64175 protein_coding 1:196692709 153925625 30_1_7 SeqId_6407_63 'LAD1 chr1:196672473_C_T$SeqId_6407_63 1 chr1:196672473_C_T rs12045503 trans 1 196672473 T C 0.6078 0.1314 0.0136 5.45e-22 'Ladinin-1 ENSG00000159166 'LAD1 intron_variant 0.994169 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect LAD1 chr1 201380833 201399915 -1 3898 protein_coding 1:196703343 4696572 30_1_7 SeqId_7084_1 'DRAXI chr1:196666793_A_C$SeqId_7084_1 1 chr1:196666793_A_C rs1089033 trans 1 196666793 A C 0.39 -0.1457 0.0138 3.8e-26 'Draxin ENSG00000162490 'DRAXIN intron_variant 0.995096 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect DRAXIN chr1 11691710 11725857 1 374946 protein_coding 1:196697663 185005953 30_1_7 SeqId_6528_95 'EXTL2 chr1:196664651_C_T$SeqId_6528_95 1 chr1:196664651_C_T rs10922098 trans 1 196664651 T C 0.6073 -0.2203 0.0136 1.04e-58 'Exostosin-like 2 ENSG00000162694 'EXTL2 intron_variant 0.999296 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect EXTL2 chr1 100872372 100895179 -1 2135 protein_coding 1:196695521 95800342 30_1_7 SeqId_6533_20 'DNS2B chr1:196664651_C_T$SeqId_6533_20 1 chr1:196664651_C_T rs10922098 trans 1 196664651 T C 0.6073 0.1235 0.0136 1.05e-19 'Deoxyribonuclease-2-beta ENSG00000137976 'DNASE2B intron_variant 0.999296 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect DNASE2B chr1 84398484 84415018 1 58511 protein_coding 1:196695521 112297037 30_1_7 SeqId_6538_90 'K2013 chr1:196652124_D_I$SeqId_6538_90 1 chr1:196652124_D_I rs33944729 trans 1 196652124 D I 0.3888 -0.0975 0.0138 1.42e-12 'Uncharacterized protein KIAA2013 ENSG00000116685 'KIAA2013 intron_variant 0.991562 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect KIAA2013 chr1 11919591 11926428 -1 90231 protein_coding 1:196682995 184756567 30_1_7 SeqId_6563_78 'HSP 70 chr1:196661730_D_I$SeqId_6563_78 1 chr1:196661730_D_I 1:196661730_D_I none 1 196661730 D I 0.3865 -0.0998 0.0132 3.96e-14 intron_variant 0.992323 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect HSPA6 chr1 161524540 161526894 1 3310 protein_coding 1:196692600 35168060 30_1_7 SeqId_6915_2 'C16L2 chr1:196668360_D_I$SeqId_6915_2 1 chr1:196668360_D_I rs34813609 trans 1 196668360 D I 0.6095 -0.1757 0.0138 4.92e-37 'CD164 sialomucin-like 2 protein ENSG00000174950 'CD164L2 intron_variant 0.998117 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect CD164L2 chr1 27379176 27383333 -1 388611 protein_coding 1:196699231 169315898 30_1_7 SeqId_6984_6 'IGSF8 chr1:196668360_D_I$SeqId_6984_6 1 chr1:196668360_D_I rs34813609 trans 1 196668360 D I 0.6095 0.1228 0.0135 1.04e-19 'Immunoglobulin superfamily member 8 ENSG00000162729 'IGSF8 intron_variant 0.998117 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect IGSF8 chr1 160091340 160098943 -1 93185 protein_coding 1:196699231 36600288 30_1_7 SeqId_9443_137 'cathepsin K chr1:196671666_D_I$SeqId_9443_137 1 chr1:196671666_D_I rs201263987 trans 1 196671666 D I 0.6106 0.1081 0.0139 7.49e-15 'Cathepsin K ENSG00000143387 'CTSK intron_variant 0.986979 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect CTSK chr1 150794880 150809577 -1 1513 protein_coding 1:196702537 45892960 30_1_7 SeqId_8858_21 'BATF3 chr1:196655743_A_C$SeqId_8858_21 1 chr1:196655743_A_C rs10801553 trans 1 196655743 A C 0.3909 0.2374 0.0136 1.83e-68 'Basic leucine zipper transcriptional factor ATF-like 3 ENSG00000123685 'BATF3 intron_variant 0.999066 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect BATF3 chr1 212686417 212699840 -1 55509 protein_coding 1:196686613 16013227 30_1_7 SeqId_7089_42 'SYT11 chr1:196672473_C_T$SeqId_7089_42 1 chr1:196672473_C_T rs12045503 trans 1 196672473 T C 0.6078 0.1241 0.0135 4.27e-20 'Synaptotagmin-11 ENSG00000132718 'SYT11 intron_variant 0.994169 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect SYT11 chr1 155859567 155885199 1 23208 protein_coding 1:196703343 40843776 30_1_7 SeqId_7127_3 'Apo A-II chr1:196655280_C_G$SeqId_7127_3 1 chr1:196655280_C_G rs1329422 trans 1 196655280 C G 0.3911 -0.1628 0.0133 1.72e-34 'Apolipoprotein A-II ENSG00000158874 'APOA2 intron_variant 0.999066 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect APOA2 chr1 161222292 161223631 -1 336 protein_coding 1:196686150 35462519 30_1_7 SeqId_7219_152 'HSP 70 chr1:196668360_D_I$SeqId_7219_152 1 chr1:196668360_D_I rs34813609 none 1 196668360 D I 0.6095 0.1143 0.0135 2.62e-17 intron_variant 0.998117 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect HSPA6 chr1 161524540 161526894 1 3310 protein_coding 1:196699231 35174691 30_1_7 SeqId_7247_1 'GORAB chr1:196668360_D_I$SeqId_7247_1 1 chr1:196668360_D_I rs34813609 trans 1 196668360 D I 0.6095 -0.1234 0.0137 2.69e-19 'RAB6-interacting golgin ENSG00000120370 'GORAB intron_variant 0.998117 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect GORAB chr1 170531819 170553834 1 92344 protein_coding 1:196699231 26167412 30_1_7 SeqId_9050_170 'CA063 chr1:196671666_D_I$SeqId_9050_170 1 chr1:196671666_D_I rs201263987 trans 1 196671666 D I 0.6106 0.1109 0.0137 6.7e-16 'Arginine/serine-rich protein 1 ENSG00000117616 'C1orf63 intron_variant 0.986979 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect RSRP1 chr1 25242249 25338213 -1 57035 protein_coding 1:196702537 171364324 30_1_7 SeqId_8081_55 'PLD5 chr1:196671666_D_I$SeqId_8081_55 1 chr1:196671666_D_I rs201263987 trans 1 196671666 D I 0.6106 0.1277 0.0137 8.95e-21 'Inactive phospholipase D5 ENSG00000180287 'PLD5 intron_variant 0.986979 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect PLD5 chr1 242082986 242524697 -1 200150 protein_coding 1:196702537 45822160 30_1_7 SeqId_7818_101 'GBP6 chr1:196664255_G_T$SeqId_7818_101 1 chr1:196664255_G_T rs12033127 trans 1 196664255 T G 0.3914 0.3444 0.0133 5.28e-147 'Guanylate-binding protein 6 ENSG00000183347 'GBP6 intron_variant 0.999766 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect GBP6 chr1 89364059 89388160 1 163351 protein_coding 1:196695125 107331066 30_1_7 SeqId_9606_4 'P210L chr1:196652124_D_I$SeqId_9606_4 1 chr1:196652124_D_I rs33944729 trans 1 196652124 D I 0.3888 -0.1636 0.0136 4.01e-33 'Nuclear pore membrane glycoprotein 210-like ENSG00000143552 'NUP210L intron_variant 0.991562 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect NUP210L chr1 153992685 154155116 -1 91181 protein_coding 1:196682995 42527879 30_1_7 SeqId_8062_15 'F176B chr1:196666044_C_T$SeqId_8062_15 1 chr1:196666044_C_T rs76258507 trans 1 196666044 T C 0.3913 0.1474 0.0137 7.53e-27 'Protein eva-1 homolog B ENSG00000142694 'EVA1B intron_variant 0.999298 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect EVA1B chr1 36322030 36324154 -1 55194 protein_coding 1:196696914 160372760 30_1_7 SeqId_9254_18 'FCERA chr1:196668360_D_I$SeqId_9254_18 1 chr1:196668360_D_I rs34813609 trans 1 196668360 D I 0.6095 -0.2724 0.0133 1.31e-92 'High affinity immunoglobulin epsilon receptor subunit alpha ENSG00000179639 'FCER1A intron_variant 0.998117 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect FCER1A chr1 159289714 159308224 1 2205 protein_coding 1:196699231 37409517 30_1_7 SeqId_9715_15 'IGSF3 chr1:196646176_G_T$SeqId_9715_15 1 chr1:196646176_G_T rs1329424 trans 1 196646176 T G 0.3901 -0.1049 0.0131 1.25e-15 'Immunoglobulin superfamily member 3 ENSG00000143061 'IGSF3 intron_variant 0.986946 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect IGSF3 chr1 116574399 116667755 -1 3321 protein_coding 1:196677046 80009291 30_1_7 SeqId_8366_19 'CA115 chr1:196665208_A_G$SeqId_8366_19 1 chr1:196665208_A_G rs10922100 trans 1 196665208 A G 0.3913 0.1791 0.0138 1.89e-38 'Uncharacterized protein C1orf115 ENSG00000162817 'C1orf115 intron_variant 1.0 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect C1orf115 chr1 220690363 220699153 1 79762 protein_coding 1:196696078 23994285 30_1_7 SeqId_9819_110 'Mcl-1 chr1:196668287_C_T$SeqId_9819_110 1 chr1:196668287_C_T rs10922102 none 1 196668287 T C 0.6087 -0.1152 0.0136 3.23e-17 'Induced myeloid leukemia cell differentiation protein Mcl-1 intron_variant 1.0 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect MCL1 chr1 150560895 150579738 -1 4170 protein_coding 1:196699157 46119419 30_1_7 SeqId_9038_12 'JTB chr1:196660261_A_G$SeqId_9038_12 1 chr1:196660261_A_G rs10801555 trans 1 196660261 A G 0.3911 0.1132 0.0138 2.64e-16 'Protein JTB ENSG00000143543 'JTB intron_variant 0.998132 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect JTB chr1 153974269 153977674 -1 10899 protein_coding 1:196691131 42713457 30_1_7 SeqId_9971_5 'CSMD2 chr1:196646176_G_T$SeqId_9971_5 1 chr1:196646176_G_T rs1329424 trans 1 196646176 T G 0.3901 -0.1296 0.0131 6.07e-23 'CUB and sushi domain-containing protein 2 ENSG00000121904 'CSMD2 intron_variant 0.986946 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect CSMD2 chr1 33513998 34165842 -1 114784 protein_coding 1:196677046 162511204 30_1_7 SeqId_9383_24 'CH3L2 chr1:196664651_C_T$SeqId_9383_24 1 chr1:196664651_C_T rs10922098 trans 1 196664651 T C 0.6073 -0.2701 0.0133 4.2e-91 'Chitinase-3-like protein 2 ENSG00000064886 'CHI3L2 intron_variant 0.999296 rs1061170 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 3 known unspecific_effect CHI3L2 chr1 111200771 111243440 1 1117 protein_coding 1:196695521 85494750 30_1_8 SeqId_4159_130 'Factor H chr1:196705009_A_G$SeqId_4159_130 1 chr1:196705009_A_G rs70621 cis 1 196705009 A G 0.1632 -0.4345 0.0176 7.18e-134 'Complement factor H ENSG00000000971 'CFH intron_variant 0.970466 rs1065489 ENSG00000000971 'CFH missense_variant ENSG00000000971 ENSG00000000971 'CFH 6 known unspecific_effect CFH chr1 196652043 196747504 1 3075 protein_coding 1:196735879 83836 30_1_9 SeqId_16055_3 'complement factor H-related 5 chr1:197001919_C_G$SeqId_16055_3 1 chr1:197001919_C_G rs79801780 cis 1 197001919 C G 0.0267 -1.061 0.0412 2.15e-146 'Complement factor H-related protein 5 ENSG00000134389 'CFHR5 intergenic_variant 0.970637 rs35662416 ENSG00000134389 'CFHR5 missense_variant ENSG00000134389 ENSG00000134389 'CFHR5 5 known unspecific_effect -0.01673 0.21597 0.938285489385698 no CFHR5 Olink CARDIOMETABOLIC(v.3602) CFHR5 chr1 196977556 197009678 1 81494 protein_coding 1:197032789 55233 30_2_1 SeqId_11143_32 'NOE3 chr1:198974904_C_T$SeqId_11143_32 1 chr1:198974904_C_T rs10919615 trans 1 198974904 T C 0.7509 0.1152 0.0157 1.97e-13 'Noelin-3 ENSG00000118733 'OLFM3 downstream_gene_variant ENSG00000233410 ENSG00000081237|ENSG00000151418|ENSG00000233410|ENSG00000235492|ENSG00000262418|ENSG00000263014 'ATP6V1G3|ATP6V1G3|PTPRC|PTPRC 1 novel unspecific_effect OLFM3 chr1 101802560 101996926 -1 118427 protein_coding 1:199005775 97008849 30_2_1 SeqId_9901_28 'EGLN1 chr1:199010721_C_T$SeqId_9901_28 1 chr1:199010721_C_T rs1434282 trans 1 199010721 T C 0.7194 0.1189 0.0148 7.77e-16 'Egl nine homolog 1 ENSG00000135766 'EGLN1 non_coding_transcript_exon_variant ENSG00000235492 ENSG00000081237|ENSG00000151418|ENSG00000233410|ENSG00000235492|ENSG00000262418|ENSG00000263014 'ATP6V1G3|ATP6V1G3|PTPRC|PTPRC 1 novel unspecific_effect EGLN1 chr1 231363751 231422287 -1 54583 protein_coding 1:199041592 32380695 30_2_2 SeqId_12703_6 'NEK7 chr1:198010781_A_G$SeqId_12703_6 1 chr1:198010781_A_G rs142662761 cis 1 198010781 A G 0.9886 0.6151 0.0634 3.17e-22 'Serine/threonine-protein kinase Nek7 ENSG00000151414 'NEK7 intergenic_variant 0.526956 rs55833332 ENSG00000151414 'NEK7 missense_variant ENSG00000151414 ENSG00000151414 'NEK7 3 novel specific_protein NEK7 chr1 198156994 198322420 1 140609 protein_coding 1:198041651 115343 301_1_3 SeqId_11616_9 'HSF1 chr8:145536753_A_G$SeqId_11616_9 1 chr8:145536753_A_G rs3757976 cis 8 145536753 A G 0.5001 0.1076 0.0127 2.98e-17 'Heat shock factor protein 1 ENSG00000185122 'HSF1 intron_variant ENSG00000185122 ENSG00000185122 'HSF1 3 novel specific_protein HSF1 chr8 144291591 144314720 1 3297 protein_coding 8:144313067 21476 303_1_1 SeqId_8080_24 'PSMP chr9:4037941_A_G$SeqId_8080_24 1 chr9:4037941_A_G rs599955 trans 9 4037941 A G 0.6632 0.1732 0.0139 1.9e-35 'Prostate-associated microseminoprotein ENSG00000215183 'MSMP intron_variant ENSG00000205808 ENSG00000205808 'PLPP6 2 novel specific_protein MSMP chr9 35752990 35756613 -1 692094 protein_coding 9:4037941 31718672 303_3_1 SeqId_5060_62 'B7-H1 chr9:5459419_C_T$SeqId_5060_62 1 chr9:5459419_C_T rs1411262 cis 9 5459419 T C 0.2515 -0.2844 0.0153 3.13e-77 'Programmed cell death 1 ligand 1 ENSG00000120217 'CD274 intron_variant ENSG00000120217 ENSG00000120217 'CD274 3 known specific_pathway -0.11342 0.072635 0.119072096415466 no PD-L1 Olink INFLAMMATION(v.3012) CD274 chr9 5450503 5470566 1 29126 protein_coding 9:5459419 8916 303_3_2 SeqId_3004_67 'PD-L2 chr9:5510644_A_G$SeqId_3004_67 1 chr9:5510644_A_G rs16923189 cis 9 5510644 A G 0.7093 -0.4907 0.0143 2.92e-258 'Programmed cell death 1 ligand 2 ENSG00000197646 'PDCD1LG2 5_prime_UTR_variant ENSG00000197646 ENSG00000197646 'PDCD1LG2 3 known specific_protein -0.51913 0.064375 5.91561634175474e-15 yes PD-L2 Olink CARDIOVASCULAR II(v.5004) PDCD1LG2 chr9 5510531 5571282 1 80380 protein_coding 9:5510644 113 305_1_1 SeqId_16890_37 'ATL1 chr9:18650547_A_G$SeqId_16890_37 1 chr9:18650547_A_G rs776786 cis 9 18650547 A G 0.9594 -0.4456 0.0313 4.71e-46 'ADAMTS-like protein 1 ENSG00000178031 'ADAMTSL1 intron_variant 0.985387 rs776755 ENSG00000178031 'ADAMTSL1 missense_variant ENSG00000178031 ENSG00000178031 'ADAMTSL1 3 novel specific_protein ADAMTSL1 chr9 17906563 18910950 1 92949 protein_coding 9:18650549 743986 306_1_1 SeqId_3773_15 'sTie-2 chr9:27201551_G_T$SeqId_3773_15 1 chr9:27201551_G_T rs117982767 cis 9 27201551 T G 0.9503 -0.5758 0.0301 1.38e-81 'Angiopoietin-1 receptor, soluble ENSG00000120156 'TEK intron_variant 0.989186 rs35030851 ENSG00000120156 'TEK missense_variant ENSG00000120156 ENSG00000120156 'TEK 3 known specific_protein -1.0302 0.12851 8.31763771102671e-15 yes TIE2 Olink CARDIOVASCULAR II(v.5004) TEK chr9 27109141 27230174 1 7010 protein_coding 9:27201553 92412 307_1_3 SeqId_12382_2 'DDX58 chr9:32533829_C_T$SeqId_12382_2 1 chr9:32533829_C_T rs7025666 cis 9 32533829 T C 0.7363 0.3629 0.0148 1.67e-132 'Probable ATP-dependent RNA helicase DDX58 ENSG00000107201 'DDX58 intergenic_variant 0.995134 rs10813831 ENSG00000107201 'DDX58 missense_variant ENSG00000107201 ENSG00000107201 'DDX58 3 novel specific_protein 0.0060968 0.066463 0.926949340938729 no DDX58 Olink IMMUNE RESPONSE(v.3202) DDX58 chr9 32455302 32526208 -1 23586 protein_coding 9:32533831 7623 307_1_4 SeqId_13381_49 'B4GT1 chr9:33113322_C_T$SeqId_13381_49 1 chr9:33113322_C_T rs7019909 cis 9 33113322 T C 0.1048 0.4131 0.0218 2.07e-80 'Beta-1,4-galactosyltransferase 1 ENSG00000086062 'B4GALT1 3_prime_UTR_variant ENSG00000086062 ENSG00000086062 'B4GALT1 3 known suggestive_specific_pathway 0.23768 0.096518 0.0141416472507015 yes B4GALT1 Olink DEVELOPMENT(v.3511) B4GALT1 chr9 33104082 33167356 -1 2683 protein_coding 9:33113324 54032 307_1_5 SeqId_19213_1 'ISK4 chr9:33234039_A_G$SeqId_19213_1 1 chr9:33234039_A_G rs1630171 cis 9 33234039 A G 0.8479 -0.3818 0.0184 8.97e-96 'Serine protease inhibitor Kazal-type 4 ENSG00000122711 'SPINK4 intron_variant 0.536677 rs706107 ENSG00000122711 'SPINK4 missense_variant ENSG00000122711 ENSG00000122711 'SPINK4 3 novel specific_protein SPINK4 chr9 33218365 33248567 1 27290 protein_coding 9:33234041 15676 307_2_1 SeqId_16583_8 'AP4A chr9:34366134_A_C$SeqId_16583_8 1 chr9:34366134_A_C rs4879779 cis 9 34366134 A C 0.2133 -0.4111 0.0147 4.9e-171 'Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] ENSG00000164978 'NUDT2 downstream_gene_variant 0.875879 rs17350674 ENSG00000186638 'KIF24 missense_variant ENSG00000164978 ENSG00000164978|ENSG00000186638 'KIF24|NUDT2 3 known unspecific_effect NUDT2 chr9 34329506 34343711 1 318 protein_coding 9:34366136 36630 307_2_3 SeqId_18864_7 'TRY3 chr9:33791164_C_T$SeqId_18864_7 1 chr9:33791164_C_T rs2005617 cis 9 33791164 T C 0.3727 -0.5547 0.0126 2.55e-423 'Trypsin-3 ENSG00000010438 'PRSS3 intron_variant 0.37498 rs143332708 ENSG00000010438 'PRSS3 inframe_insertion ENSG00000010438 ENSG00000010438 'PRSS3 3 novel specific_protein PRSS3 chr9 33750679 33799231 1 5646 protein_coding 9:33791166 40487 307_2_4 SeqId_8068_43 'K1161 chr9:34329702_C_G$SeqId_8068_43 1 chr9:34329702_C_G rs2039344 cis 9 34329702 C G 0.3734 -0.2356 0.0135 2.46e-68 'Uncharacterized family 31 glucosidase KIAA1161 ENSG00000164976 'KIAA1161 intron_variant 0.308873 rs7852399 ENSG00000164976 'KIAA1161 missense_variant ENSG00000164976 ENSG00000164976 'MYORG 3 known suggestive_specific_pathway MYORG chr9 34366666 34376898 -1 57462 protein_coding 9:34329704 47194 307_2_5 SeqId_14101_2 'CNTFR alpha chr9:34593086_A_G$SeqId_14101_2 1 chr9:34593086_A_G rs10972159 cis 9 34593086 A G 0.019 -0.7266 0.0497 2.16e-48 'Ciliary neurotrophic factor receptor subunit alpha ENSG00000122756 'CNTFR upstream_gene_variant ENSG00000122756 ENSG00000122756 'CNTFR 3 known specific_protein CNTFR chr9 34551432 34590140 -1 1271 protein_coding 9:34593088 2948 307_3_3 SeqId_18216_22 'IL-11 RA chr9:34656479_A_G$SeqId_18216_22 1 chr9:34656479_A_G rs11575578 cis 9 34656479 A G 0.0674 0.539 0.0255 6.19e-99 'Interleukin-11 receptor subunit alpha ENSG00000137070 'IL11RA intron_variant ENSG00000137070 ENSG00000137070 'IL11RA 3 known specific_pathway IL11RA chr9 34652162 34661902 1 3590 protein_coding 9:34656482 4320 307_3_4 SeqId_2516_57 '6Ckine chr9:34723035_A_C$SeqId_2516_57 1 chr9:34723035_A_C rs10814138 cis 9 34723035 A C 0.3105 -0.0996 0.0145 7.14e-12 'C-C motif chemokine 21 ENSG00000137077 'CCL21 downstream_gene_variant ENSG00000137077 ENSG00000137077 'CCL21 3 known specific_protein CCL21 chr9 34709005 34710136 -1 6366 protein_coding 9:34723038 12902 307_3_5 SeqId_7009_8 'CD72 chr9:35614924_A_G$SeqId_7009_8 1 chr9:35614924_A_G rs7465764 cis 9 35614924 A G 0.941 -0.359 0.0285 2.12e-36 'B-cell differentiation antigen CD72 ENSG00000137101 'CD72 intron_variant 0.967199 rs34791102 ENSG00000137101 'CD72 missense_variant ENSG00000137101 ENSG00000137101 'CD72 3 known specific_protein CD72 chr9 35609982 35646810 -1 971 protein_coding 9:35614927 31883 307_3_6 SeqId_15522_2 'GAPR1 chr9:36153437_C_G$SeqId_15522_2 1 chr9:36153437_C_G rs4878643 cis 9 36153437 C G 0.2936 -0.2769 0.0145 8.76e-81 'Golgi-associated plant pathogenesis-related protein 1 ENSG00000122694 'GLIPR2 intron_variant ENSG00000122694 ENSG00000122694 'GLIPR2 3 novel specific_protein GLIPR2 chr9 36136536 36163913 1 152007 protein_coding 9:36153440 16904 307_4_1 SeqId_18295_102 'GRHPR chr9:37422656_C_T$SeqId_18295_102 1 chr9:37422656_C_T rs4878690 cis 9 37422656 T C 0.3264 0.4266 0.0136 1.09e-214 'Glyoxylate reductase/hydroxypyruvate reductase ENSG00000137106 'GRHPR upstream_gene_variant ENSG00000137106 ENSG00000137106 'GRHPR 3 novel specific_protein GRHPR chr9 37422666 37436990 1 9380 protein_coding 9:37422659 7 308_1_1 SeqId_8992_1 'TMEM2 chr9:74267330_C_G$SeqId_8992_1 1 chr9:74267330_C_G rs4143770 cis 9 74267330 C G 0.284 -0.2084 0.0147 2.26e-45 'Transmembrane protein 2 ENSG00000135048 'TMEM2 regulatory_region_variant ENSG00000135048 ENSG00000135048 'CEMIP2 3 known specific_protein CEMIP2 chr9 71683366 71816690 -1 23670 protein_coding 9:71652414 164276 309_1_1 SeqId_11265_8 'Retinal dehydrogenase 1 chr9:75590448_D_I$SeqId_11265_8 1 chr9:75590448_D_I rs5898287 cis 9 75590448 D I 0.6828 -0.1484 0.0137 3.28e-27 'Retinal dehydrogenase 1 ENSG00000165092 'ALDH1A1 intron_variant ENSG00000165092 ENSG00000165092 'ALDH1A1 3 novel specific_protein ALDH1A1 chr9 72900671 73080442 -1 216 protein_coding 9:72975533 104909 309_1_2 SeqId_4960_72 'annexin I chr9:75777421_C_T$SeqId_4960_72 1 chr9:75777421_C_T rs62541553 cis 9 75777421 T C 0.0428 0.4858 0.0315 1.1e-53 'Annexin A1 ENSG00000135046 'ANXA1 intron_variant ENSG00000135046 ENSG00000135046 'ANXA1 3 known specific_protein 0.061011 0.1577 0.699020641031591 no ANXA1 Olink ONCOLOGY II(v.7002) ANXA1 chr9 73151865 73170393 1 301 protein_coding 9:73162505 10640 31_1_1 SeqId_15529_33 'Cysteine-rich protein 1 chr1:201456799_G_T$SeqId_15529_33 1 chr1:201456799_G_T rs12729389 cis 1 201456799 T G 0.6389 0.1005 0.0137 2.33e-13 'Cysteine and glycine-rich protein 1 ENSG00000159176 'CSRP1 intron_variant ENSG00000159176 ENSG00000159176 'CSRP1 5 novel specific_pathway CSRP1 chr1 201483530 201509456 -1 1465 protein_coding 1:201487671 21785 31_1_2 SeqId_9249_17 'TMEM9 chr1:201120730_A_C$SeqId_9249_17 1 chr1:201120730_A_C rs2068152 cis 1 201120730 A C 0.3796 0.1038 0.0139 9.48e-14 'Transmembrane protein 9 ENSG00000116857 'TMEM9 intron_variant ENSG00000116857 ENSG00000116857 'TMEM9 3 novel specific_protein TMEM9 chr1 201134772 201171574 -1 252839 protein_coding 1:201151602 19972 31_2_2 SeqId_12386_11 'AMPB chr1:201950949_C_T$SeqId_12386_11 1 chr1:201950949_C_T rs11810017 cis 1 201950949 T C 0.687 -0.3211 0.0137 7.09e-122 'Aminopeptidase B ENSG00000176393 'RNPEP upstream_gene_variant 0.159944 rs3820439 ENSG00000176393 'RNPEP missense_variant ENSG00000176393 ENSG00000176393 'RNPEP 3 known specific_protein RNPEP chr1 201982372 202006147 1 6051 protein_coding 1:201981821 551 31_2_4 SeqId_14688_6 'PTN7 chr1:202097309_C_T$SeqId_14688_6 1 chr1:202097309_C_T rs76841249 cis 1 202097309 T C 0.0146 -0.411 0.0576 9.32e-13 'Tyrosine-protein phosphatase non-receptor type 7 ENSG00000143851 'PTPN7 synonymous_variant ENSG00000143851 ENSG00000143851 'PTPN7 3 novel specific_protein PTPN7 chr1 202147013 202161588 -1 5778 protein_coding 1:202128181 33407 31_2_5 SeqId_11104_13 'YKL-40 chr1:203153634_C_G$SeqId_11104_13 1 chr1:203153634_C_G rs2071579 cis 1 203153634 C G 0.4725 0.9866 0.0098 1.20e-2203 'Chitinase-3-like protein 1 ENSG00000133048 'CHI3L1 intron_variant 0.999768 rs880633 ENSG00000133048 'CHI3L1 missense_variant ENSG00000133048 ENSG00000133048 'CHI3L1 3 known specific_pathway -0.12818 0.06246 0.0407005239440233 no CHI3L1 Olink CARDIOVASCULAR III(v.6112) CHI3L1 chr1 203178931 203186704 -1 1116 protein_coding 1:203184506 2198 31_2_6 SeqId_3600_2 'Chitotriosidase-1 chr1:203184766_C_T$SeqId_3600_2 1 chr1:203184766_C_T rs872583 cis 1 203184766 T C 0.7936 1.0618 0.0127 1.31e-1520 'Chitotriosidase-1 ENSG00000133063 'CHIT1 downstream_gene_variant 0.96799 rs150192398 ENSG00000133063 'CHIT1 inframe_deletion ENSG00000133063 ENSG00000133063 'CHIT1 3 known specific_pathway 1.0844 0.05548 4.09260659730013e-63 yes CHIT1 Olink CARDIOVASCULAR III(v.6112) CHIT1 chr1 203212827 203273641 -1 1118 protein_coding 1:203215638 58003 31_2_7 SeqId_6367_66 'fibromodulin chr1:203318144_A_G$SeqId_6367_66 1 chr1:203318144_A_G rs16851364 cis 1 203318144 A G 0.1247 -0.2193 0.0194 1.47e-29 'fibromodulin ENSG00000122176 'FMOD intron_variant ENSG00000122176 ENSG00000122176 'FMOD 3 known specific_protein FMOD chr1 203340628 203351758 -1 2331 protein_coding 1:203349016 2742 31_3_3 SeqId_3396_54 'Renin chr1:204207097_C_T$SeqId_3396_54 1 chr1:204207097_C_T rs141995914 cis 1 204207097 T C 0.9886 -0.8033 0.0659 3.62e-34 'Renin ENSG00000143839 'REN intron_variant ENSG00000143839 ENSG00000143839 'REN 3 known specific_protein -1.0568 0.28208 0.000201187039514943 yes REN Olink CARDIOVASCULAR II(v.5004) REN chr1 204154819 204190324 -1 5972 protein_coding 1:204237969 47645 31_4_1 SeqId_7179_69 'NFASC chr1:204948659_A_G$SeqId_7179_69 1 chr1:204948659_A_G rs6667532 cis 1 204948659 A G 0.8952 -0.7262 0.0205 8.04e-274 'Neurofascin ENSG00000163531 'NFASC synonymous_variant ENSG00000163531 ENSG00000163531 'NFASC 3 known specific_protein NFASC chr1 204828651 205022822 1 23114 protein_coding 1:204979531 150880 31_4_2 SeqId_3296_92 'CNTN2 chr1:205012198_G_T$SeqId_3296_92 1 chr1:205012198_G_T rs2071533 cis 1 205012198 T G 0.1337 0.9292 0.0175 9.38e-615 'Contactin-2 ENSG00000184144 'CNTN2 upstream_gene_variant ENSG00000184144 ENSG00000184144 'CNTN2 3 known specific_protein 1.0853 0.071864 1.86208713666288e-42 yes CNTN2 Olink ORGAN DAMAGE(v.3301) CNTN2 chr1 205042937 205078289 1 6900 protein_coding 1:205043070 133 31_5_1 SeqId_5764_4 'GALT2 chr1:207277349_D_I$SeqId_5764_4 1 chr1:207277349_D_I rs3841377 trans 1 207277349 D I 0.1707 0.128 0.0179 8.94e-13 'Polypeptide N-acetylgalactosaminyltransferase 2 ENSG00000143641 'GALNT2 upstream_gene_variant 0.178249 rs55867570 ENSG00000123838 'C4BPA missense_variant ENSG00000123843 ENSG00000123843 'C4BPB 1 known suggestive_specific_pathway GALNT2 chr1 230057990 230282122 1 2590 protein_coding 1:207104005 22953985 31_5_10 SeqId_15570_99 'Complement receptor type 2 chr1:207632796_A_G$SeqId_15570_99 1 chr1:207632796_A_G rs17044525 cis 1 207632796 A G 0.8911 0.2704 0.0209 3.97e-38 'Complement receptor type 2 ENSG00000117322 'CR2 intron_variant 0.261726 rs4308977 ENSG00000117322 'CR2 missense_variant ENSG00000117322 ENSG00000117322 'CR2 3 novel suggestive_specific_pathway CR2 chr1 207454230 207489895 1 1380 protein_coding 1:207459451 5221 31_5_11 SeqId_19556_12 'Complement receptor type 1 chr1:207750568_C_T$SeqId_19556_12 1 chr1:207750568_C_T rs679515 cis 1 207750568 T C 0.18 0.5857 0.0167 1.3e-270 'Complement receptor type 1 ENSG00000203710 'CR1 intron_variant 0.11355 rs4844609 ENSG00000203710 'CR1 missense_variant ENSG00000203710 ENSG00000203710 'CR1 3 known suggestive_specific_pathway CR1 chr1 207496147 207641765 1 1378 protein_coding 1:207577223 81076 31_5_13 SeqId_17682_1 'CD46 chr1:207945970_A_G$SeqId_17682_1 1 chr1:207945970_A_G rs113208992 cis 1 207945970 A G 0.5979 -0.4022 0.0132 1.4e-202 'Membrane cofactor protein ENSG00000117335 'CD46 intron_variant ENSG00000117335 ENSG00000117335 'CD46 3 novel specific_protein -0.067009 0.064909 0.302426609067676 no CD46 Olink CARDIOMETABOLIC(v.3602) CD46 chr1 207752054 207795513 1 4179 protein_coding 1:207772625 20571 31_5_2 SeqId_15376_134 'CATE chr1:206328248_D_I$SeqId_15376_134 1 chr1:206328248_D_I 1:206328248_D_I cis 1 206328248 D I 0.8169 0.5185 0.0182 1.47e-178 'Cathepsin E ENSG00000196188 'CTSE intron_variant ENSG00000196188 ENSG00000196188 'CTSE 3 novel specific_protein CTSE chr1 206008535 206023909 -1 1510 protein_coding 1:206013120 10789 31_5_3 SeqId_3820_68 'MAPK2 chr1:206904464_C_T$SeqId_3820_68 1 chr1:206904464_C_T rs10863805 cis 1 206904464 T C 0.3093 0.3167 0.0131 7.5e-129 'MAP kinase-activated protein kinase 2 ENSG00000162889 'MAPKAPK2 intron_variant ENSG00000162889 ENSG00000162889 'MAPKAPK2 6 known specific_pathway MAPKAPK2 chr1 206684905 206734281 1 9261 protein_coding 1:206731119 46214 31_5_4 SeqId_3216_2 'PIGR chr1:207105641_C_T$SeqId_3216_2 1 chr1:207105641_C_T rs908702 cis 1 207105641 T C 0.4477 -0.1686 0.0132 4.22e-37 'Polymeric immunoglobulin receptor ENSG00000162896 'PIGR intron_variant 0.993655 rs2275531 ENSG00000162896 'PIGR missense_variant ENSG00000162896 ENSG00000162896 'PIGR 3 known unspecific_effect -0.0085603 0.061623 0.889575882216881 no PIgR Olink CARDIOVASCULAR II(v.5004) PIGR chr1 206928522 206946466 -1 5284 protein_coding 1:206932296 14170 31_5_5 SeqId_6574_11 'FAIM3 chr1:207149630_C_T$SeqId_6574_11 1 chr1:207149630_C_T rs1856747 cis 1 207149630 T C 0.1268 -0.1912 0.0208 3.13e-20 'Fas apoptotic inhibitory molecule 3 ENSG00000162894 'FAIM3 intergenic_variant ENSG00000162894 ENSG00000162894 'FCMR 3 novel specific_protein FCMR chr1 206903317 206923247 -1 9214 protein_coding 1:206976285 53038 31_5_6 SeqId_9449_150 'C4b-binding protein alpha chain chr1:207281706_D_I$SeqId_9449_150 1 chr1:207281706_D_I rs34101855 cis 1 207281706 D I 0.8727 -0.5162 0.0197 1.25e-151 'C4b-binding protein alpha chain ENSG00000123838 'C4BPA intron_variant ENSG00000123838 ENSG00000123838 'C4BPA 3 known unspecific_effect C4BPA chr1 207104233 207144972 1 722 protein_coding 1:207108362 4129 31_5_7 SeqId_8597_1 'TMEM9 chr1:207282149_A_C$SeqId_8597_1 1 chr1:207282149_A_C rs2842700 trans 1 207282149 A C 0.0542 0.2561 0.0301 1.97e-17 'Transmembrane protein 9 ENSG00000116857 'TMEM9 intron_variant ENSG00000123838 ENSG00000123838|ENSG00000232621 'C4BPA 1 known unspecific_effect TMEM9 chr1 201134772 201171574 -1 252839 protein_coding 1:207108804 5937230 31_5_9 SeqId_5069_9 'DAF chr1:207439015_C_T$SeqId_5069_9 1 chr1:207439015_C_T rs6684804 cis 1 207439015 T C 0.2319 -0.5476 0.015 6.38e-290 'Complement decay-accelerating factor ENSG00000196352 'CD55 intron_variant,non_coding_transcript_variant ENSG00000196352 ENSG00000196352 'CD55 3 known suggestive_specific_pathway CD55 chr1 207321532 207386804 1 1604 protein_coding 1:207265670 55862 310_1_1 SeqId_16853_5 'NRK1 chr9:77707300_A_T$SeqId_16853_5 1 chr9:77707300_A_T rs11144225 cis 9 77707300 A T 0.5967 0.3236 0.0132 2.6e-133 'Nicotinamide riboside kinase 1 ENSG00000106733 'NMRK1 intron_variant ENSG00000106733 ENSG00000106733 'NMRK1 3 novel specific_protein NMRK1 chr9 75060573 75088217 -1 54981 protein_coding 9:75092384 4167 311_1_1 SeqId_13059_33 'RIFK chr9:79322720_A_G$SeqId_13059_33 1 chr9:79322720_A_G rs680729 cis 9 79322720 A G 0.2349 -0.2231 0.0152 4.88e-49 'Riboflavin kinase ENSG00000135002 'RFK synonymous_variant ENSG00000135002 ENSG00000135002 'RFK 3 novel specific_protein RFK chr9 76385526 76394517 -1 55312 protein_coding 9:76707804 313287 312_1_1 SeqId_18342_2 'SERC chr9:80864512_C_T$SeqId_18342_2 1 chr9:80864512_C_T rs7874282 cis 9 80864512 T C 0.2147 -0.1445 0.0154 5.42e-21 'Phosphoserine aminotransferase ENSG00000135069 'PSAT1 intron_variant ENSG00000135069 ENSG00000135069 'PSAT1 3 novel specific_protein PSAT1 chr9 78297125 78330093 1 29968 protein_coding 9:78249596 47529 313_1_1 SeqId_17456_53 'GOLM1 chr9:88720605_A_G$SeqId_17456_53 1 chr9:88720605_A_G rs10780749 cis 9 88720605 A G 0.1204 0.3001 0.0201 1.71e-50 'Golgi membrane protein 1 ENSG00000135052 'GOLM1 intergenic_variant ENSG00000135052 ENSG00000135052 'GOLM1 3 known unspecific_effect GOLM1 chr9 86026146 86100173 -1 51280 protein_coding 9:86105690 5517 313_1_1 SeqId_8983_7 'GOLM1 chr9:88720605_A_G$SeqId_8983_7 1 chr9:88720605_A_G rs10780749 cis 9 88720605 A G 0.1204 0.2095 0.0205 1.52e-24 'Golgi membrane protein 1 ENSG00000135052 'GOLM1 intergenic_variant ENSG00000135052 ENSG00000135052 'GOLM1 3 known unspecific_effect GOLM1 chr9 86026146 86100173 -1 51280 protein_coding 9:86105690 5517 314_1_1 SeqId_5737_61 'SEM4D chr9:91994433_C_T$SeqId_5737_61 1 chr9:91994433_C_T rs45464494 cis 9 91994433 T C 0.0773 -1.4919 0.0204 4.57e-1164 'Semaphorin-4D ENSG00000187764 'SEMA4D missense_variant ENSG00000187764 ENSG00000187764 'SEMA4D 3 known specific_protein SEMA4D chr9 89360787 89498130 -1 10507 protein_coding 9:89379518 118612 315_1_1 SeqId_10722_13 'KSYK chr9:93563884_C_T$SeqId_10722_13 1 chr9:93563884_C_T rs34221447 cis 9 93563884 T C 0.2173 -0.1734 0.0155 6.02e-29 'Tyrosine-protein kinase SYK ENSG00000165025 'SYK upstream_gene_variant ENSG00000165025 ENSG00000165025 'SYK 3 novel unspecific_effect SYK chr9 90801787 90898549 1 6850 protein_coding 9:90801602 185 315_1_1 SeqId_11378_37 'KSYK chr9:93563884_C_T$SeqId_11378_37 1 chr9:93563884_C_T rs34221447 cis 9 93563884 T C 0.2173 -0.1695 0.0156 1.63e-27 'Tyrosine-protein kinase SYK ENSG00000165025 'SYK upstream_gene_variant ENSG00000165025 ENSG00000165025 'SYK 3 novel unspecific_effect SYK chr9 90801787 90898549 1 6850 protein_coding 9:90801602 185 315_2_1 SeqId_17224_12 'MIME chr9:95201540_A_T$SeqId_17224_12 1 chr9:95201540_A_T rs7045409 cis 9 95201540 A T 0.3701 0.4199 0.0127 1.81e-240 'Mimecan ENSG00000106809 'OGN intron_variant ENSG00000106809 ENSG00000106809|ENSG00000106819 'ASPN|OGN 3 known unspecific_effect OGN chr9 92383268 92404696 -1 4969 protein_coding 9:92439258 34562 315_2_1 SeqId_6451_64 'ASPN chr9:95115492_A_C$SeqId_6451_64 1 chr9:95115492_A_C rs7848055 cis 9 95115492 A C 0.6711 0.4434 0.0128 5.14e-261 'Asporin ENSG00000106819 'ASPN intron_variant ENSG00000106819 ENSG00000106809|ENSG00000106819 'ASPN|OGN 3 known unspecific_effect ASPN chr9 92456205 92482506 -1 54829 protein_coding 9:92353210 129296 315_2_2 SeqId_15522_2 'GAPR1 chr9:95905552_A_C$SeqId_15522_2 1 chr9:95905552_A_C rs4743894 trans 9 95905552 A C 0.6118 0.1366 0.0138 4.57e-23 'Golgi-associated plant pathogenesis-related protein 1 ENSG00000122694 'GLIPR2 upstream_gene_variant 0.305802 rs2275848 ENSG00000131669 'NINJ1 missense_variant ENSG00000203364 ENSG00000131669|ENSG00000203364 'NINJ1 1 novel suggestive_specific_pathway GLIPR2 chr9 36136536 36163913 1 152007 protein_coding 9:93143270 57006734 315_2_3 SeqId_7861_9 'ROR2 chr9:94495608_C_T$SeqId_7861_9 1 chr9:94495608_C_T rs10820900 cis 9 94495608 T C 0.3512 0.1605 0.0134 2.78e-33 'Tyrosine-protein kinase transmembrane receptor ROR2 ENSG00000169071 'ROR2 missense_variant ENSG00000169071 ENSG00000169071 'ROR2 3 novel specific_pathway ROR2 chr9 91563091 91950228 -1 4920 protein_coding 9:91733326 216902 315_3_1 SeqId_9867_23 'F16P2 chr9:97352468_G_T$SeqId_9867_23 1 chr9:97352468_G_T rs499480 cis 9 97352468 T G 0.8594 0.2727 0.0188 1.9e-47 'Fructose-1,6-bisphosphatase isozyme 2 ENSG00000130957 'FBP2 intron_variant 0.987512 rs573212 ENSG00000130957 'FBP2 missense_variant ENSG00000130957 ENSG00000130957 'FBP2 3 known specific_protein FBP2 chr9 94558720 94593824 -1 8789 protein_coding 9:94590186 3638 315_3_2 SeqId_7206_20 'F16P1 chr9:97355195_A_G$SeqId_7206_20 1 chr9:97355195_A_G rs2679606 cis 9 97355195 A G 0.0703 -0.2011 0.0248 5.09e-16 'Fructose-1,6-bisphosphatase 1 ENSG00000165140 'FBP1 intron_variant 0.993313 rs1769259 ENSG00000165140 'FBP1 missense_variant ENSG00000165140 ENSG00000165140 'FBP1 3 novel specific_pathway FBP1 chr9 94603133 94640249 -1 2203 protein_coding 9:94592913 47336 316_1_2 SeqId_10815_2 'HABP4 chr9:99192919_A_C$SeqId_10815_2 1 chr9:99192919_A_C rs10820606 cis 9 99192919 A C 0.7588 -0.8033 0.0142 1.71e-697 'Intracellular hyaluronan-binding protein 4 ENSG00000130956 'HABP4 intergenic_variant ENSG00000130956 ENSG00000130956 'HABP4 5 known unspecific_effect HABP4 chr9 96450169 96491336 1 22927 protein_coding 9:96430637 19532 316_1_4 SeqId_3364_76 'Cathepsin V chr9:99909044_C_T$SeqId_3364_76 1 chr9:99909044_C_T rs12686511 cis 9 99909044 T C 0.2088 0.2163 0.0161 5.04e-41 'Cathepsin L2 ENSG00000136943 'CTSV intergenic_variant ENSG00000136943 ENSG00000136943 'CTSV 3 novel specific_protein CTSV chr9 97029677 97156556 -1 1515 protein_coding 9:97146762 9794 316_1_5 SeqId_17802_4 'SIAS chr9:100823135_C_G$SeqId_17802_4 1 chr9:100823135_C_G rs1058446 cis 9 100823135 C G 0.2422 0.1788 0.015 1.49e-32 'Sialic acid synthase ENSG00000095380 'NANS missense_variant ENSG00000095380 ENSG00000095380 'NANS 3 novel specific_protein NANS chr9 98056732 98083077 1 54187 protein_coding 9:98060853 4121 316_2_1 SeqId_8974_172 'COFA1 chr9:101633220_C_T$SeqId_8974_172 1 chr9:101633220_C_T rs7874287 cis 9 101633220 T C 0.3057 -0.2232 0.0141 2.33e-56 'Collagen alpha-1(XV) chain ENSG00000204291 'COL15A1 intron_variant,non_coding_transcript_variant ENSG00000204291 ENSG00000204291 'COL15A1 3 novel specific_protein COL15A1 chr9 98943179 99070792 1 1306 protein_coding 9:98870938 72241 317_1_1 SeqId_15641_20 'TEFF1 chr9:103286432_D_I$SeqId_15641_20 1 chr9:103286432_D_I rs372969265 cis 9 103286432 D I 0.8311 -0.1394 0.0172 5.78e-16 'Tomoregulin-1 ENSG00000241697 'TMEFF1 intron_variant ENSG00000241697 ENSG00000241697 'TMEFF1 3 novel specific_protein TMEFF1 chr9 100473149 100577636 1 8577 protein_coding 9:100524151 51002 317_1_2 SeqId_18185_118 'ALDOB chr9:104209068_A_G$SeqId_18185_118 1 chr9:104209068_A_G rs142540788 cis 9 104209068 A G 0.9878 0.9965 0.0617 1.3e-58 'Fructose-bisphosphate aldolase B ENSG00000136872 'ALDOB upstream_gene_variant 0.498043 rs1800546 ENSG00000136872 'ALDOB missense_variant ENSG00000136872 ENSG00000136872 'ALDOB 3 novel specific_protein ALDOB chr9 101420560 101449664 -1 229 protein_coding 9:101446786 2878 32_1_1 SeqId_12428_2 'LYPL1 chr1:219340555_D_I$SeqId_12428_2 1 chr1:219340555_D_I rs3084102 cis 1 219340555 D I 0.1155 0.371 0.0198 3.38e-78 'Lysophospholipase-like protein 1 ENSG00000143353 'LYPLAL1 intron_variant,non_coding_transcript_variant ENSG00000143353 ENSG00000143353 'LYPLAL1 3 novel specific_protein LYPLAL1 chr1 219173869 219212865 1 127018 protein_coding 1:219167214 6655 320_1_1 SeqId_11109_56 'SVEP1 chr9:113312231_C_G$SeqId_11109_56 1 chr9:113312231_C_G rs61751937 cis 9 113312231 C G 0.0292 0.9411 0.0382 2.84e-134 'Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 ENSG00000165124 'SVEP1 missense_variant ENSG00000165124 ENSG00000165124 'SVEP1 3 known unspecific_effect SVEP1 chr9 110365248 110579880 -1 79987 protein_coding 9:110549951 29929 320_1_1 SeqId_11178_21 'SVEP1 chr9:113312231_C_G$SeqId_11178_21 1 chr9:113312231_C_G rs61751937 cis 9 113312231 C G 0.0292 1.0255 0.0378 5.74e-162 'Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 ENSG00000165124 'SVEP1 missense_variant ENSG00000165124 ENSG00000165124 'SVEP1 3 known unspecific_effect SVEP1 chr9 110365248 110579880 -1 79987 protein_coding 9:110549951 29929 320_1_2 SeqId_19617_5 'LTB4DH chr9:114357952_C_T$SeqId_19617_5 1 chr9:114357952_C_T rs59165439 cis 9 114357952 T C 0.2504 -0.6647 0.0141 4.47e-485 'Prostaglandin reductase 1 ENSG00000106853 'PTGR1 intron_variant 0.21588 rs1053959 ENSG00000106853 'PTGR1 missense_variant ENSG00000106853 ENSG00000106853 'PTGR1 3 novel suggestive_specific_pathway PTGR1 chr9 111549722 111599893 -1 22949 protein_coding 9:111595672 4221 320_3_3 SeqId_19482_11 'HDHD3 chr9:116136198_C_T$SeqId_19482_11 1 chr9:116136198_C_T rs1043836 cis 9 116136198 T C 0.6392 0.1875 0.0128 2.32e-48 'Haloacid dehalogenase-like hydrolase domain-containing protein 3 ENSG00000119431 'HDHD3 missense_variant ENSG00000119431 ENSG00000119431 'HDHD3 3 novel specific_protein HDHD3 chr9 113373419 113376986 -1 81932 protein_coding 9:113373918 3068 320_3_4 SeqId_15523_9 'HEM2 chr9:116153891_C_G$SeqId_15523_9 1 chr9:116153891_C_G rs1800435 cis 9 116153891 C G 0.9188 0.4219 0.0257 1.94e-60 'Delta-aminolevulinic acid dehydratase ENSG00000148218 'ALAD missense_variant ENSG00000148218 ENSG00000148218 'ALAD 3 novel specific_protein ALAD chr9 113386312 113401290 -1 210 protein_coding 9:113391611 9679 320_3_5 SeqId_15453_3 'a1-Microglobulin chr9:116827079_C_T$SeqId_15453_3 1 chr9:116827079_C_T rs10817564 cis 9 116827079 T C 0.2696 -0.1539 0.0149 4.9e-25 'Alpha-1-microglobulin ENSG00000106927 'AMBP intron_variant ENSG00000106927 ENSG00000106927 'AMBP 3 novel unspecific_effect 0.016758 0.072674 0.817732012864142 no AMBP Olink CARDIOVASCULAR II(v.5004) AMBP chr9 114060127 114078328 -1 259 protein_coding 9:114064799 13529 320_4_2 SeqId_4155_3 'Tenascin chr9:117835899_C_T$SeqId_4155_3 1 chr9:117835899_C_T rs1138545 cis 9 117835899 T C 0.1568 1.2912 0.0136 3.95e-1960 'Tenascin ENSG00000041982 'TNC missense_variant ENSG00000041982 ENSG00000041982 'TNC 7 known suggestive_specific_pathway 0.032237 0.088043 0.714414071381094 no TNC Olink CARDIOMETABOLIC(v.3602) TNC chr9 115019575 115118257 -1 3371 protein_coding 9:115073620 44637 320_4_2 SeqId_5675_6 'Tenascin chr9:117835899_C_T$SeqId_5675_6 1 chr9:117835899_C_T rs1138545 none 9 117835899 T C 0.157 -1.2683 0.0139 1.16e-1810 missense_variant ENSG00000041982 ENSG00000041982 'TNC 7 known suggestive_specific_pathway TNC chr9 115019575 115118257 -1 3371 protein_coding 9:115073620 44637 320_4_2 SeqId_6042_52 'Tenascin chr9:117835899_C_T$SeqId_6042_52 1 chr9:117835899_C_T rs1138545 none 9 117835899 T C 0.1568 -0.5659 0.0166 3.11e-256 missense_variant ENSG00000041982 ENSG00000041982 'TNC 7 known suggestive_specific_pathway TNC chr9 115019575 115118257 -1 3371 protein_coding 9:115073620 44637 320_4_2 SeqId_7131_207 'Tenascin chr9:117835899_C_T$SeqId_7131_207 1 chr9:117835899_C_T rs1138545 none 9 117835899 T C 0.157 -1.0169 0.0158 4.00e-902 missense_variant ENSG00000041982 ENSG00000041982 'TNC 7 known suggestive_specific_pathway TNC chr9 115019575 115118257 -1 3371 protein_coding 9:115073620 44637 320_4_3 SeqId_5738_25 'Tenascin chr9:117901465_A_G$SeqId_5738_25 1 chr9:117901465_A_G rs7849467 none 9 117901465 A G 0.7013 0.295 0.0142 3.17e-95 upstream_gene_variant 0.248135 rs1138545 ENSG00000041982 'TNC missense_variant ENSG00000173077 ENSG00000041982 'TNC 3 known suggestive_specific_pathway TNC chr9 115019575 115118257 -1 3371 protein_coding 9:115139186 20929 320_4_3 SeqId_6260_14 'Tenascin chr9:117888305_D_I$SeqId_6260_14 1 chr9:117888305_D_I rs113723385 none 9 117888305 D I 0.2982 -0.2402 0.0144 1.19e-62 intron_variant 0.249719 rs1138545 ENSG00000041982 'TNC missense_variant ENSG00000236461 ENSG00000041982 'TNC 3 known suggestive_specific_pathway TNC chr9 115019575 115118257 -1 3371 protein_coding 9:115126027 7770 320_4_4 SeqId_3421_54 'CD30 Ligand chr9:117691270_A_G$SeqId_3421_54 1 chr9:117691270_A_G rs1006026 cis 9 117691270 A G 0.5679 0.219 0.0136 4.75e-58 'Tumor necrosis factor ligand superfamily member 8 ENSG00000106952 'TNFSF8 intron_variant ENSG00000106952 ENSG00000106952 'TNFSF8 3 novel specific_protein TNFSF8 chr9 114893343 114930595 -1 944 protein_coding 9:114928990 1605 321_1_1 SeqId_3647_49 'TLR4:MD-2 complex chr9:120473466_A_G$SeqId_3647_49 1 chr9:120473466_A_G rs117343502 cis 9 120473466 A G 0.0561 -0.8586 0.0273 1.82e-217 'Toll-like receptor 4:Lymphocyte antigen 96 complex ENSG00000136869|ENSG00000154589 'TLR4|LY96 intron_variant 0.974118 rs4986790 ENSG00000136869 'TLR4 missense_variant ENSG00000136869|ENSG00000154589 ENSG00000136869|ENSG00000154589 'LY96|TLR4 3 known specific_protein TLR4 chr9 117704175 117724735 1 7099 protein_coding 9:117711188 7013 322_1_1 SeqId_2381_52 'C5 chr9:123767261_D_I$SeqId_2381_52 1 chr9:123767261_D_I rs41309886 cis 9 123767261 D I 0.2184 -0.2964 0.0162 1.35e-74 'Complement C5 ENSG00000106804 'C5 intron_variant 0.214123 rs17611 ENSG00000106804 'C5 missense_variant ENSG00000106804 ENSG00000039537|ENSG00000106804 'C5|C6 3 known unspecific_effect C5 chr9 120952335 121050275 -1 727 protein_coding 9:121004984 45291 322_1_1 SeqId_4482_66 'C5b, 6 Complex chr9:123767261_D_I$SeqId_4482_66 1 chr9:123767261_D_I rs41309886 cis 9 123767261 D I 0.2184 -0.2887 0.0162 8.7e-71 'Complement C5b-C6 complex ENSG00000106804|ENSG00000039537 'C5|C6 intron_variant 0.214123 rs17611 ENSG00000106804 'C5 missense_variant ENSG00000106804|ENSG00000039537 ENSG00000039537|ENSG00000106804 'C5|C6 3 known unspecific_effect C5 chr9 120952335 121050275 -1 727 protein_coding 9:121004984 45291 322_1_2 SeqId_2851_63 'C5a chr9:123787999_A_G$SeqId_2851_63 1 chr9:123787999_A_G rs17220750 cis 9 123787999 A G 0.1003 0.2589 0.022 7.81e-32 'C5a anaphylatoxin ENSG00000106804 'C5 intron_variant ENSG00000106804 ENSG00000106804 'C5 3 known unspecific_effect C5 chr9 120952335 121050275 -1 727 protein_coding 9:121025721 24554 322_1_3 SeqId_4775_34 'Gelsolin chr9:124033044_A_C$SeqId_4775_34 1 chr9:124033044_A_C rs10985196 cis 9 124033044 A C 0.2063 -0.1854 0.0157 3.49e-32 'Gelsolin ENSG00000148180 'GSN intron_variant ENSG00000148180 ENSG00000148180 'GSN 3 novel specific_protein GSN chr9 121207794 121332843 1 2934 protein_coding 9:121270766 62972 324_1_2 SeqId_4908_6 'Endoglin chr9:130601277_C_T$SeqId_4908_6 1 chr9:130601277_C_T rs11794565 cis 9 130601277 T C 0.4538 0.0979 0.0133 2.12e-13 'Endoglin ENSG00000106991 'ENG intron_variant ENSG00000106991 ENSG00000106991 'ENG 3 novel specific_protein ENG chr9 127815013 127854658 -1 2022 protein_coding 9:127838998 15660 324_1_4 SeqId_18458_4 'PGES2 chr9:130884753_C_T$SeqId_18458_4 1 chr9:130884753_C_T rs13283456 cis 9 130884753 T C 0.2041 -0.2269 0.0161 5.77e-45 'Prostaglandin E synthase 2 ENSG00000148334 'PTGES2 missense_variant ENSG00000148334 ENSG00000148334 'PTGES2 3 novel specific_protein PTGES2 chr9 128120693 128128462 -1 80142 protein_coding 9:128122474 5988 324_1_5 SeqId_18222_34 'SHLB2 chr9:131788129_C_G$SeqId_18222_34 1 chr9:131788129_C_G rs7870053 cis 9 131788129 C G 0.525 0.4195 0.0124 4.51e-252 'Endophilin-B2 ENSG00000148341 'SH3GLB2 intron_variant ENSG00000148341 ENSG00000148341 'SH3GLB2 3 novel specific_protein SH3GLB2 chr9 129007036 129028331 -1 56904 protein_coding 9:129025850 2481 324_1_6 SeqId_12637_7 'CACP chr9:131855219_D_I$SeqId_12637_7 1 chr9:131855219_D_I rs34313463 cis 9 131855219 D I 0.276 -0.155 0.0138 3.93e-29 'Carnitine O-acetyltransferase ENSG00000095321 'CRAT downstream_gene_variant ENSG00000095321 ENSG00000095321 'CRAT 3 novel unspecific_effect CRAT chr9 129094142 129111189 -1 1384 protein_coding 9:129092941 18248 325_1_1 SeqId_18871_24 'AIF1L chr9:133936775_C_T$SeqId_18871_24 1 chr9:133936775_C_T rs2315073 cis 9 133936775 T C 0.69 -0.9598 0.0112 1.85e-1597 'Allograft inflammatory factor 1-like ENSG00000126878 'AIF1L intron_variant 0.209297 rs2315075 ENSG00000126878 'AIF1L missense_variant ENSG00000126878 ENSG00000126878 'AIF1L 3 novel specific_protein AIF1L chr9 131096476 131123152 1 83543 protein_coding 9:131061388 35088 326_1_10 SeqId_6379_62 'ATL2 chr9:136397834_A_G$SeqId_6379_62 1 chr9:136397834_A_G rs1008250 cis 9 136397834 A G 0.7252 -0.1118 0.0161 4.47e-12 'ADAMTS-like protein 2 ENSG00000197859 'ADAMTSL2 intron_variant ENSG00000197859 ENSG00000197859 'ADAMTSL2 3 novel unspecific_effect ADAMTSL2 chr9 133532164 133575519 1 9719 protein_coding 9:133532712 548 326_1_2 SeqId_4908_6 'Endoglin chr9:136138765_D_I$SeqId_4908_6 1 chr9:136138765_D_I rs779860630 trans 9 136138765 D I 0.1989 -0.3701 0.0157 2.93e-122 'Endoglin ENSG00000106991 'ENG intron_variant 0.297282 rs41302673 ENSG00000198870 'C9orf96 missense_variant ENSG00000175164|ENSG00000160271|ENSG00000160323|ENSG00000281244 ENSG00000175164 'ABO 5 known unspecific_effect -0.1628 0.078905 0.0396186798370326 yes ENG Olink CARDIOMETABOLIC(v.3602) ENG chr9 127815013 127854658 -1 2022 protein_coding 9:133263363 5408705 326_1_2 SeqId_11109_56 'SVEP1 chr9:136137065_A_G$SeqId_11109_56 1 chr9:136137065_A_G rs687621 trans 9 136137065 A G 0.6624 -0.0986 0.0136 3.53e-13 'Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 ENSG00000165124 'SVEP1 intron_variant 0.140219 rs41302673 ENSG00000198870 'C9orf96 missense_variant ENSG00000175164 ENSG00000175164 'ABO 5 known unspecific_effect SVEP1 chr9 110365248 110579880 -1 79987 protein_coding 9:133261662 22681782 326_1_2 SeqId_11178_21 'SVEP1 chr9:136137065_A_G$SeqId_11178_21 1 chr9:136137065_A_G rs687621 trans 9 136137065 A G 0.6624 -0.1052 0.0135 6.96e-15 'Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 ENSG00000165124 'SVEP1 intron_variant 0.140219 rs41302673 ENSG00000198870 'C9orf96 missense_variant ENSG00000175164 ENSG00000175164 'ABO 5 known unspecific_effect SVEP1 chr9 110365248 110579880 -1 79987 protein_coding 9:133261662 22681782 326_1_2 SeqId_13381_49 'B4GT1 chr9:136139907_D_I$SeqId_13381_49 1 chr9:136139907_D_I rs149092047 trans 9 136139907 D I 0.2702 0.218 0.0149 3.56e-48 'Beta-1,4-galactosyltransferase 1 ENSG00000086062 'B4GALT1 intron_variant 0.197112 rs41302673 ENSG00000198870 'C9orf96 missense_variant ENSG00000148248|ENSG00000280951 ENSG00000175164 'ABO 5 known unspecific_effect B4GALT1 chr9 33104082 33167356 -1 2683 protein_coding 9:133264504 100097148 326_1_2 SeqId_17456_53 'GOLM1 chr9:136146597_C_T$SeqId_17456_53 1 chr9:136146597_C_T rs550057 trans 9 136146597 T C 0.2697 0.6408 0.0134 4.38e-499 'Golgi membrane protein 1 ENSG00000135052 'GOLM1 intron_variant 0.196234 rs41302673 ENSG00000198870 'C9orf96 missense_variant ENSG00000175164|ENSG00000148248|ENSG00000160271|ENSG00000170835|ENSG00000197859|ENSG00000280951 ENSG00000175164 'ABO 5 known unspecific_effect GOLM1 chr9 86026146 86100173 -1 51280 protein_coding 9:133271182 47171009 326_1_2 SeqId_3421_54 'CD30 Ligand chr9:136146597_C_T$SeqId_3421_54 1 chr9:136146597_C_T rs550057 trans 9 136146597 T C 0.2697 0.1286 0.0151 1.98e-17 'Tumor necrosis factor ligand superfamily member 8 ENSG00000106952 'TNFSF8 intron_variant 0.196234 rs41302673 ENSG00000198870 'C9orf96 missense_variant ENSG00000175164 ENSG00000175164 'ABO 5 known unspecific_effect TNFSF8 chr9 114893343 114930595 -1 944 protein_coding 9:133271182 18340587 326_1_2 SeqId_3647_49 'TLR4:MD-2 complex chr9:136149399_A_G$SeqId_3647_49 1 chr9:136149399_A_G rs507666 trans 9 136149399 A G 0.2001 -0.231 0.0161 1.12e-46 'Toll-like receptor 4:Lymphocyte antigen 96 complex ENSG00000136869|ENSG00000154589 'TLR4|LY96 intron_variant 0.294239 rs41302673 ENSG00000198870 'C9orf96 missense_variant ENSG00000175164|ENSG00000148248|ENSG00000148297|ENSG00000148303|ENSG00000160271|ENSG00000280858|ENSG00000280951|ENSG00000281022 ENSG00000175164 'ABO 5 known unspecific_effect TLR4 chr9 117704175 117724735 1 7099 protein_coding 9:133273983 15569808 326_1_2 SeqId_8983_7 'GOLM1 chr9:136139907_D_I$SeqId_8983_7 1 chr9:136139907_D_I rs149092047 trans 9 136139907 D I 0.2701 0.7583 0.0131 3.45e-730 'Golgi membrane protein 1 ENSG00000135052 'GOLM1 intron_variant 0.197112 rs41302673 ENSG00000198870 'C9orf96 missense_variant ENSG00000175164|ENSG00000148248|ENSG00000160271|ENSG00000170835|ENSG00000197859|ENSG00000280951 ENSG00000175164 'ABO 5 known unspecific_effect GOLM1 chr9 86026146 86100173 -1 51280 protein_coding 9:133264504 47164331 326_1_2 SeqId_8992_1 'TMEM2 chr9:136138765_D_I$SeqId_8992_1 1 chr9:136138765_D_I rs779860630 trans 9 136138765 D I 0.1989 -0.1272 0.0169 5.88e-14 'Transmembrane protein 2 ENSG00000135048 'TMEM2 intron_variant 0.297282 rs41302673 ENSG00000198870 'C9orf96 missense_variant ENSG00000175164 ENSG00000175164 'ABO 5 known unspecific_effect CEMIP2 chr9 71683366 71816690 -1 23670 protein_coding 9:133263363 61446673 326_1_2 SeqId_9253_52 'BGAT chr9:136144309_A_G$SeqId_9253_52 1 chr9:136144309_A_G rs576125 cis 9 136144309 A G 0.3354 1.2278 0.0079 3.90e-5248 'Histo-blood group ABO system transferase ENSG00000175164 'ABO intron_variant ENSG00000175164 ENSG00000175164 'ABO 5 known unspecific_effect ABO chr9 133233278 133276024 -1 protein_coding 9:133268897 7127 326_1_2 SeqId_5703_26 'NOE1 chr9:136149399_A_G$SeqId_5703_26 1 chr9:136149399_A_G rs507666 trans 9 136149399 A G 0.2001 -0.1505 0.0161 8.04e-21 'Noelin ENSG00000130558 'OLFM1 intron_variant 0.294239 rs41302673 ENSG00000198870 'C9orf96 missense_variant ENSG00000175164 ENSG00000175164 'ABO 5 known unspecific_effect OLFM1 chr9 135075422 135121180 1 10439 protein_coding 9:133273983 1801439 326_1_2 SeqId_8397_147 'QSOX2 chr9:136139907_D_I$SeqId_8397_147 1 chr9:136139907_D_I rs149092047 trans 9 136139907 D I 0.2702 0.9706 0.0116 5.20e-1523 'Sulfhydryl oxidase 2 ENSG00000165661 'QSOX2 intron_variant 0.197112 rs41302673 ENSG00000198870 'C9orf96 missense_variant ENSG00000175164 ENSG00000175164 'ABO 5 known unspecific_effect QSOX2 chr9 136206333 136245812 -1 169714 protein_coding 9:133264504 2981308 326_1_3 SeqId_5107_7 'Notch 1 chr9:136142185_C_T$SeqId_5107_7 1 chr9:136142185_C_T rs8176672 trans 9 136142185 T C 0.0652 0.413 0.0255 8.37e-59 'Neurogenic locus notch homolog protein 1 ENSG00000148400 'NOTCH1 intron_variant ENSG00000175164 ENSG00000148297|ENSG00000170835|ENSG00000281022 'CEL|MED22|MED22 2 known unspecific_effect 0.32897 0.11955 0.00615176872709868 yes NOTCH1 Olink CARDIOMETABOLIC(v.3602) NOTCH1 chr9 136494433 136546048 -1 4851 protein_coding 9:133266772 3279276 326_1_3 SeqId_3773_15 'sTie-2 chr9:136142185_C_T$SeqId_3773_15 1 chr9:136142185_C_T rs8176672 trans 9 136142185 T C 0.0652 0.6376 0.0261 1.41e-131 'Angiopoietin-1 receptor, soluble ENSG00000120156 'TEK intron_variant ENSG00000175164|ENSG00000160271|ENSG00000160323|ENSG00000281244 ENSG00000148297|ENSG00000170835|ENSG00000281022 'CEL|MED22|MED22 2 known unspecific_effect 0.74341 0.11407 1.8134266758708e-10 yes TIE2 Olink CARDIOVASCULAR II(v.5004) TEK chr9 27109141 27230174 1 7010 protein_coding 9:133266772 106157631 326_1_6 SeqId_9796_4 'CEL chr9:135927793_C_G$SeqId_9796_4 1 chr9:135927793_C_G rs56272996 cis 9 135927793 C G 0.9693 -0.7039 0.037 1.27e-80 'Bile salt-activated lipase ENSG00000170835 'CEL intron_variant ENSG00000170835 ENSG00000170835 'CEL 3 known specific_protein CEL chr9 133061981 133071861 1 1056 protein_coding 9:133052406 9575 326_1_8 SeqId_5680_54 'OBP2B chr9:136087047_C_T$SeqId_5680_54 1 chr9:136087047_C_T rs4962104 cis 9 136087047 T C 0.2027 -0.34 0.0158 8.03e-103 'Odorant-binding protein 2b ENSG00000171102 'OBP2B upstream_gene_variant ENSG00000171102 ENSG00000171102 'OBP2B 3 known unspecific_effect OBP2B chr9 133205277 133209250 -1 29989 protein_coding 9:133211660 2410 326_1_9 SeqId_3175_51 'ATS13 chr9:136297880_A_G$SeqId_3175_51 1 chr9:136297880_A_G rs35516997 cis 9 136297880 A G 0.088 -0.9386 0.0214 3.44e-420 'A disintegrin and metalloproteinase with thrombospondin motifs 13 ENSG00000160323 'ADAMTS13 intron_variant 0.992436 rs28647808 ENSG00000160323 'ADAMTS13 missense_variant ENSG00000160323 ENSG00000160323 'ADAMTS13 3 known suggestive_specific_pathway -0.53434 0.10959 1.47502710175976e-06 yes ADAM-TS13 Olink CARDIOVASCULAR II(v.5004) ADAMTS13 chr9 133414358 133459402 1 11093 protein_coding 9:133432759 18401 326_2_2 SeqId_13717_15 'FCN2 chr9:137779091_G_T$SeqId_13717_15 1 chr9:137779091_G_T rs7851696 cis 9 137779091 T G 0.1089 -1.0503 0.0193 1.21e-645 'Ficolin-2 ENSG00000160339 'FCN2 missense_variant ENSG00000160339 ENSG00000160339 'FCN2 6 known unspecific_effect -0.74768 0.098029 1.28233058265602e-13 yes FCN2 Olink CARDIOMETABOLIC(v.3602) FCN2 chr9 134880810 134887523 1 2220 protein_coding 9:134887245 6435 326_2_3 SeqId_3313_21 'FCN2 chr9:137752540_A_T$SeqId_3313_21 1 chr9:137752540_A_T rs57136797 cis 9 137752540 A T 0.8519 0.547 0.0187 1.31e-188 'Ficolin-2 ENSG00000160339 'FCN2 intergenic_variant 0.14934 rs7851696 ENSG00000160339 'FCN2 missense_variant ENSG00000160339 ENSG00000160339 'FCN2 3 known unspecific_effect 0.67478 0.078312 9.8401110576113e-17 yes FCN2 Olink CARDIOMETABOLIC(v.3602) FCN2 chr9 134880810 134887523 1 2220 protein_coding 9:134860694 20116 326_2_5 SeqId_15582_25 'FCN1 chr9:137775212_A_G$SeqId_15582_25 1 chr9:137775212_A_G rs7037264 cis 9 137775212 A G 0.3973 0.4391 0.0129 3.46e-255 'Ficolin-1 ENSG00000085265 'FCN1 intron_variant ENSG00000085265 ENSG00000085265 'FCN1 3 known specific_pathway FCN1 chr9 134903232 134917912 -1 2219 protein_coding 9:134883366 34546 326_2_6 SeqId_5703_26 'NOE1 chr9:137989785_C_G$SeqId_5703_26 1 chr9:137989785_C_G rs10858334 cis 9 137989785 C G 0.8572 -0.1745 0.0188 1.63e-20 'Noelin ENSG00000130558 'OLFM1 intron_variant ENSG00000130558 ENSG00000130558 'OLFM1 3 known specific_protein OLFM1 chr9 135075422 135121180 1 10439 protein_coding 9:135097939 22517 326_2_7 SeqId_11708_2 'LCN1 chr9:138404116_A_G$SeqId_11708_2 1 chr9:138404116_A_G rs11103042 cis 9 138404116 A G 0.1531 -0.1979 0.0186 1.95e-26 'Lipocalin-1 ENSG00000160349 'LCN1 intergenic_variant ENSG00000160349 ENSG00000160349 'LCN1 3 novel unspecific_effect LCN1 chr9 135521438 135526540 1 3933 protein_coding 9:135512270 9168 326_2_8 SeqId_5680_54 'OBP2B chr9:138467801_C_T$SeqId_5680_54 1 chr9:138467801_C_T rs705666 trans 9 138467801 T C 0.8128 -0.7454 0.0151 1.14e-531 'Odorant-binding protein 2b ENSG00000171102 'OBP2B intron_variant ENSG00000122136 ENSG00000122136 'OBP2A 5 known specific_protein OBP2B chr9 133205277 133209250 -1 29989 protein_coding 9:135575955 2366705 326_3_2 SeqId_8397_147 'QSOX2 chr9:139105813_D_I$SeqId_8397_147 1 chr9:139105813_D_I rs77836657 cis 9 139105813 D I 0.4996 0.3583 0.0131 3.78e-165 'Sulfhydryl oxidase 2 ENSG00000165661 'QSOX2 intron_variant 0.130668 rs12380852 ENSG00000165661 'QSOX2 missense_variant ENSG00000165661 ENSG00000165661 'QSOX2 3 known specific_protein QSOX2 chr9 136206333 136245812 -1 169714 protein_coding 9:136213968 31844 326_3_3 SeqId_11405_150 'CARD9 chr9:139266496_C_T$SeqId_11405_150 1 chr9:139266496_C_T rs4077515 cis 9 139266496 T C 0.4281 0.1667 0.0134 1.67e-35 'Caspase recruitment domain-containing protein 9 ENSG00000187796 'CARD9 missense_variant ENSG00000187796 ENSG00000187796 'CARD9 3 novel specific_protein CARD9 chr9 136361903 136373681 -1 64170 protein_coding 9:136372044 1637 326_3_4 SeqId_5107_7 'Notch 1 chr9:139408551_C_T$SeqId_5107_7 1 chr9:139408551_C_T rs9411207 cis 9 139408551 T C 0.3483 0.1066 0.0137 8.05e-15 'Neurogenic locus notch homolog protein 1 ENSG00000148400 'NOTCH1 intron_variant ENSG00000148400 ENSG00000148400 'NOTCH1 3 novel specific_protein NOTCH1 chr9 136494433 136546048 -1 4851 protein_coding 9:136514099 31949 326_4_1 SeqId_10514_5 'PGD2 synthase chr9:139856639_C_G$SeqId_10514_5 1 chr9:139856639_C_G rs908839 cis 9 139856639 C G 0.4806 -0.1926 0.0137 8.56e-45 'Prostaglandin-H2 D-isomerase ENSG00000107317 'PTGDS regulatory_region_variant 0.984009 rs2386136 ENSG00000198454 'C9orf141 missense_variant ENSG00000107317 ENSG00000107317|ENSG00000198454 'PTGDS 3 known unspecific_effect PTGDS chr9 136975092 136981742 1 5730 protein_coding 9:136962187 12905 326_4_2 SeqId_14708_59 'CO8G chr9:139840471_G_T$SeqId_14708_59 1 chr9:139840471_G_T rs7862602 cis 9 139840471 T G 0.5227 -0.4484 0.013 6.46e-261 'Complement component C8 gamma chain ENSG00000176919 'C8G intron_variant 0.202249 rs17613 ENSG00000176919 'C8G missense_variant ENSG00000176919 ENSG00000176919 'C8G 6 known unspecific_effect C8G chr9 136945185 136946975 1 733 protein_coding 9:136946019 834 326_4_4 SeqId_16882_27 'PHP14 chr9:139760830_D_I$SeqId_16882_27 1 chr9:139760830_D_I rs76229681 cis 9 139760830 D I 0.7428 -0.265 0.0152 4.83e-68 '14 kDa phosphohistidine phosphatase ENSG00000054148 'PHPT1 upstream_gene_variant ENSG00000054148 ENSG00000054148 'PHPT1 3 known suggestive_specific_pathway PHPT1 chr9 136848724 136851027 1 29085 protein_coding 9:136866379 17655 326_4_6 SeqId_8346_9 'DPP2 chr9:140008750_C_G$SeqId_8346_9 1 chr9:140008750_C_G rs10747049 cis 9 140008750 C G 0.7504 0.6693 0.0138 2.70e-513 'Dipeptidyl peptidase 2 ENSG00000176978 'DPP7 missense_variant ENSG00000176978 ENSG00000176978 'DPP7 3 known unspecific_effect 0.50549 0.066274 1.28528665994362e-13 yes DPP7 Olink METABOLISM(v.3402) DPP7 chr9 137110546 137115177 -1 29952 protein_coding 9:137114298 879 327_1_2 SeqId_17832_12 'IDI2 chr10:1065710_C_T$SeqId_17832_12 1 chr10:1065710_C_T rs1044261 cis 10 1065710 T C 0.0788 -0.3647 0.0241 1.5e-51 'Isopentenyl-diphosphate delta-isomerase 2 ENSG00000148377 'IDI2 stop_gained ENSG00000148377 ENSG00000148377 'IDI2 3 novel suggestive_specific_pathway IDI2 chr10 1018910 1025859 -1 91734 protein_coding 10:1019770 6089 327_1_3 SeqId_17712_7 'IDI1 chr10:1094909_C_G$SeqId_17712_7 1 chr10:1094909_C_G rs4880760 cis 10 1094909 C G 0.9667 0.2955 0.0352 4.87e-17 'Isopentenyl-diphosphate Delta-isomerase 1 ENSG00000067064 'IDI1 missense_variant ENSG00000067064 ENSG00000067064 'IDI1 3 novel specific_protein IDI1 chr10 1039152 1049119 -1 3422 protein_coding 10:1048969 150 329_1_1 SeqId_17377_1 'Aldose reductase-like C3 chr10:5150516_D_I$SeqId_17377_1 1 chr10:5150516_D_I 10:5150516_I_D cis 10 5150516 D I 0.6016 -0.2468 0.0133 1.01e-76 'Aldo-keto reductase family 1 member C3 ENSG00000196139 'AKR1C3 downstream_gene_variant 0.305327 rs4881396 ENSG00000196139 'AKR1C3 start_lost ENSG00000196139 ENSG00000196139 'AKR1C3 3 novel suggestive_specific_pathway AKR1C3 chr10 5035354 5107686 1 8644 protein_coding 10:5108324 72970 329_1_2 SeqId_18397_5 'AK1C4 chr10:5267191_A_G$SeqId_18397_5 1 chr10:5267191_A_G rs140107293 cis 10 5267191 A G 0.8465 0.7012 0.0161 2.33e-414 'Aldo-keto reductase family 1 member C4 ENSG00000198610 'AKR1C4 intergenic_variant 0.99701 rs3829125 ENSG00000198610 'AKR1C4 missense_variant ENSG00000198610 ENSG00000198610 'AKR1C4 3 novel unspecific_effect AKR1C4 chr10 5195462 5218949 1 1109 protein_coding 10:5225228 29766 329_1_3 SeqId_2647_66 'Rab GDP dissociation inhibitor beta chr10:5840683_D_I$SeqId_2647_66 1 chr10:5840683_D_I rs60583998 cis 10 5840683 D I 0.2191 -0.127 0.0147 6.0e-18 'Rab GDP dissociation inhibitor beta ENSG00000057608 'GDI2 intron_variant ENSG00000057608 ENSG00000057608 'GDI2 3 known specific_protein GDI2 chr10 5765223 5842132 -1 2665 protein_coding 10:5798721 43411 329_2_1 SeqId_3445_53 'IL-15 Ra chr10:6016620_C_T$SeqId_3445_53 1 chr10:6016620_C_T rs8177643 cis 10 6016620 T C 0.3327 0.1057 0.0139 2.94e-14 'Interleukin-15 receptor subunit alpha ENSG00000134470 'IL15RA intron_variant ENSG00000134470 ENSG00000134470 'IL15RA 3 known unspecific_effect 0.24189 0.067253 0.000355631318568985 yes IL-15RA Olink INFLAMMATION(v.3012) IL15RA chr10 5943639 5978187 -1 3601 protein_coding 10:5974657 3530 329_2_1 SeqId_14054_17 'IL-15 Ra chr10:6008958_C_T$SeqId_14054_17 1 chr10:6008958_C_T rs8177683 cis 10 6008958 T C 0.3312 0.3606 0.0133 1.27e-161 'Interleukin-15 receptor subunit alpha ENSG00000134470 'IL15RA intron_variant ENSG00000134470 ENSG00000134470 'IL15RA 3 known unspecific_effect 0.24177 0.067386 0.000367705393378215 yes IL-15RA Olink INFLAMMATION(v.3012) IL15RA chr10 5943639 5978187 -1 3601 protein_coding 10:5966995 11192 329_2_2 SeqId_17391_10 'SPF45 chr10:6137083_C_T$SeqId_17391_10 1 chr10:6137083_C_T rs7096838 cis 10 6137083 T C 0.9612 0.5926 0.033 3.85e-72 'Splicing factor 45 ENSG00000134453 'RBM17 intron_variant ENSG00000134453 ENSG00000134453 'RBM17 3 novel specific_protein RBM17 chr10 6089034 6117457 1 84991 protein_coding 10:6095120 6086 330_1_2 SeqId_9326_33 'ITI heavy chain H2 chr10:7753366_A_G$SeqId_9326_33 1 chr10:7753366_A_G rs4463754 cis 10 7753366 A G 0.9363 -1.1987 0.0253 5.91e-490 'Inter-alpha-trypsin inhibitor heavy chain H2 ENSG00000151655 'ITIH2 intron_variant 0.997196 rs73621253 ENSG00000151655 'ITIH2 missense_variant ENSG00000151655 ENSG00000151655 'ITIH2 7 known suggestive_specific_pathway ITIH2 chr10 7703316 7749520 1 3698 protein_coding 10:7711403 8087 330_1_3 SeqId_8233_2 'ITIH5 chr10:7698738_A_G$SeqId_8233_2 1 chr10:7698738_A_G rs6602258 cis 10 7698738 A G 0.7537 0.2926 0.0153 1.17e-81 'Inter-alpha-trypsin inhibitor heavy chain H5 ENSG00000123243 'ITIH5 intron_variant ENSG00000123243 ENSG00000123243 'ITIH5 4 known suggestive_specific_pathway ITIH5 chr10 7559270 7666998 -1 80760 protein_coding 10:7656775 10223 331_1_1 SeqId_17761_2 'NUDT5 chr10:12250620_C_T$SeqId_17761_2 1 chr10:12250620_C_T rs7895525 cis 10 12250620 T C 0.7589 -0.109 0.0156 3.28e-12 'ADP-sugar pyrophosphatase ENSG00000165609 'NUDT5 intron_variant ENSG00000165609 ENSG00000165609 'NUDT5 3 known specific_protein NUDT5 chr10 12165330 12196144 -1 11164 protein_coding 10:12208621 12477 331_2_1 SeqId_10977_55 'UCMA chr10:13283177_C_T$SeqId_10977_55 1 chr10:13283177_C_T rs1537771 cis 10 13283177 T C 0.1498 -0.4296 0.0189 1.33e-114 'Unique cartilage matrix-associated protein ENSG00000165623 'UCMA intergenic_variant ENSG00000165623 ENSG00000165623 'UCMA 3 known specific_protein UCMA chr10 13221766 13234374 -1 221044 protein_coding 10:13241177 6803 332_1_1 SeqId_4962_52 'ARMEL chr10:14862082_C_G$SeqId_4962_52 1 chr10:14862082_C_G rs61738953 cis 10 14862082 C G 0.9635 1.1681 0.037 2.59e-219 'Cerebral dopamine neurotrophic factor ENSG00000185267 'CDNF missense_variant ENSG00000185267 ENSG00000185267 'CDNF 7 known suggestive_specific_pathway 0.55271 0.16393 0.000807235030248838 yes CDNF Olink CELL REGULATION(v.3701) CDNF chr10 14819245 14838575 -1 441549 protein_coding 10:14820083 18492 332_2_1 SeqId_13563_259 'ACBD7 chr10:15130453_C_G$SeqId_13563_259 1 chr10:15130453_C_G rs72774385 cis 10 15130453 C G 0.9402 0.328 0.0284 8.65e-31 'Acyl-CoA-binding domain-containing protein 7 ENSG00000176244 'ACBD7 intron_variant ENSG00000176244 ENSG00000176244 'ACBD7 3 novel specific_protein ACBD7 chr10 15075475 15088776 -1 414149 protein_coding 10:15088454 322 333_1_1 SeqId_5586_66 'MINP1 chr10:17848398_A_G$SeqId_5586_66 1 chr10:17848398_A_G 10:17848398_A_G trans 10 17848398 A G 0.6177 -0.1121 0.0158 1.28e-12 'Multiple inositol polyphosphate phosphatase 1 ENSG00000107789 'MINPP1 upstream_gene_variant 0.230224 rs1926736 ENSG00000183748 'MRC1L1 missense_variant ENSG00000136738 ENSG00000026025|ENSG00000136738 'STAM|VIM 1 known unspecific_effect MINPP1 chr10 87504875 87553461 1 9562 protein_coding 10:17806399 69698476 333_1_3 SeqId_8233_2 'ITIH5 chr10:17891705_A_G$SeqId_8233_2 1 chr10:17891705_A_G rs1926736 trans 10 17891705 A G 0.3916 -0.0983 0.014 2.03e-12 'Inter-alpha-trypsin inhibitor heavy chain H5 ENSG00000123243 'ITIH5 missense_variant ENSG00000183748 ENSG00000183748 ' 3 known unspecific_effect ITIH5 chr10 7559270 7666998 -1 80760 protein_coding 10:17849701 10182703 333_1_4 SeqId_15581_16 'FANK1 chr10:16876402_A_G$SeqId_15581_16 1 chr10:16876402_A_G rs703059 trans 10 16876402 A G 0.4879 -0.0943 0.0134 2.22e-12 'Fibronectin type 3 and ankyrin repeat domains protein 1 ENSG00000203780 'FANK1 intron_variant ENSG00000107611 ENSG00000148484 'RSU1 3 novel unspecific_effect FANK1 chr10 125896564 126009592 1 92565 protein_coding 10:16834403 109062161 333_1_5 SeqId_11436_6 'AINX chr10:16946819_G_T$SeqId_11436_6 1 chr10:16946819_G_T rs796667 trans 10 16946819 T G 0.624 -0.1092 0.0137 1.93e-15 'Alpha-internexin ENSG00000148798 'INA intron_variant 0.149727 rs1801240 ENSG00000107611 'CUBN missense_variant ENSG00000026025 ENSG00000026025 'VIM 5 novel suggestive_specific_pathway INA chr10 103277138 103290346 1 9118 protein_coding 10:16904820 86372318 333_1_5 SeqId_15540_6 'Vimentin chr10:16946819_G_T$SeqId_15540_6 1 chr10:16946819_G_T rs796667 cis 10 16946819 T G 0.6241 -0.1443 0.0131 4.5e-28 'Vimentin ENSG00000026025 'VIM intron_variant 0.149727 rs1801240 ENSG00000107611 'CUBN missense_variant ENSG00000026025 ENSG00000026025 'VIM 5 novel suggestive_specific_pathway VIM chr10 17228241 17237593 1 7431 protein_coding 10:16904820 323421 333_1_6 SeqId_12635_9 'TRDMT chr10:17192362_C_T$SeqId_12635_9 1 chr10:17192362_C_T rs6602180 cis 10 17192362 T C 0.539 0.5259 0.0119 1.44e-426 'tRNA (cytosine(38)-C(5))-methyltransferase ENSG00000107614 'TRDMT1 intron_variant 0.996638 rs11254413 ENSG00000107614 'TRDMT1 missense_variant ENSG00000107614 ENSG00000107614 'TRDMT1 3 novel specific_protein TRDMT1 chr10 17137336 17202054 -1 1787 protein_coding 10:17150363 51691 333_1_7 SeqId_2637_77 'Macrophage mannose receptor chr10:17865664_A_G$SeqId_2637_77 1 chr10:17865664_A_G rs181242111 cis 10 17865664 A G 0.1339 0.7189 0.0203 2.28e-273 'Macrophage mannose receptor 1 ENSG00000120586 'MRC1 intron_variant 0.161439 rs201810168 ENSG00000120586 'MRC1 missense_variant ENSG00000120586 ENSG00000120586 ' 3 known unspecific_effect MRC1 chr10 17809348 17911164 1 4360 protein_coding 10:17823665 14317 334_1_2 SeqId_11342_59 'PXDC2 chr10:20598372_A_T$SeqId_11342_59 1 chr10:20598372_A_T rs12412765 cis 10 20598372 A T 0.1059 -0.1708 0.0207 1.45e-16 'Plexin domain-containing protein 2 ENSG00000120594 'PLXDC2 intergenic_variant 0.923749 rs2778979 ENSG00000120594 'PLXDC2 missense_variant ENSG00000120594 ENSG00000120594 'PLXDC2 3 novel specific_protein PLXDC2 chr10 19816239 20289856 1 84898 protein_coding 10:20309443 493204 335_1_1 SeqId_12697_30 'PI42A chr10:23180619_A_T$SeqId_12697_30 1 chr10:23180619_A_T rs4498867 cis 10 23180619 A T 0.7356 0.2281 0.0143 3.45e-57 'Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha ENSG00000150867 'PIP4K2A intergenic_variant 0.409977 rs10828395 ENSG00000165309 'ARMC3 missense_variant ENSG00000150867 ENSG00000150867 'PIP4K2A 5 novel specific_pathway PIP4K2A chr10 22534854 22714578 -1 5305 protein_coding 10:22891690 177112 337_1_1 SeqId_9028_5 'PAPD1 chr10:30628478_C_T$SeqId_9028_5 1 chr10:30628478_C_T rs2254706 cis 10 30628478 T C 0.7196 0.1645 0.015 4.87e-28 'Poly(A) RNA polymerase, mitochondrial ENSG00000107951 'MTPAP intron_variant 0.999449 rs1047991 ENSG00000107951 'MTPAP missense_variant ENSG00000107951 ENSG00000107951 'MTPAP 3 novel specific_protein MTPAP chr10 30309801 30374448 -1 55149 protein_coding 10:30339549 34899 338_1_1 SeqId_5542_22 'NRP1 chr10:33483308_A_G$SeqId_5542_22 1 chr10:33483308_A_G rs2506150 cis 10 33483308 A G 0.3647 -0.3107 0.0136 5.44e-115 'Neuropilin-1 ENSG00000099250 'NRP1 intron_variant 0.184279 rs2228638 ENSG00000099250 'NRP1 missense_variant ENSG00000099250 ENSG00000099250 'NRP1 3 known specific_protein -0.34453 0.065436 2.11057116288435e-07 yes NRP1 Olink CARDIOMETABOLIC(v.3602) NRP1 chr10 33177492 33336262 -1 8829 protein_coding 10:33194380 141882 339_1_2 SeqId_3220_40 'RET chr10:37940722_D_I$SeqId_3220_40 1 chr10:37940722_D_I rs552123594 trans 10 37940722 D I 0.3547 -0.1288 0.0142 9.85e-20 'Proto-oncogene tyrosine-protein kinase receptor Ret ENSG00000165731 'RET intergenic_variant none ENSG00000235687 ' 1 novel specific_protein RET chr10 43077064 43130351 1 5979 protein_coding 10:37651795 5425269 340_1_1 SeqId_3220_40 'RET chr10:43354941_A_T$SeqId_3220_40 1 chr10:43354941_A_T rs2796561 cis 10 43354941 A T 0.3097 0.4044 0.0134 9.69e-199 'Proto-oncogene tyrosine-protein kinase receptor Ret ENSG00000165731 'RET intergenic_variant ENSG00000165731 ENSG00000165731 'RET 3 known specific_protein 0.48601 0.061252 1.48936107771092e-14 yes RET Olink ONCOLOGY II(v.7002) RET chr10 43077064 43130351 1 5979 protein_coding 10:42859493 217571 340_1_2 SeqId_10772_21 'CGAT2 chr10:43654558_C_T$SeqId_10772_21 1 chr10:43654558_C_T rs2435340 cis 10 43654558 T C 0.7184 0.1815 0.0148 2.13e-34 'Chondroitin sulfate N-acetylgalactosaminyltransferase 2 ENSG00000169826 'CSGALNACT2 intron_variant 0.995684 rs2435381 ENSG00000169826 'CSGALNACT2 missense_variant ENSG00000169826 ENSG00000169826 'CSGALNACT2 3 known unspecific_effect CSGALNACT2 chr10 43138445 43185302 1 55454 protein_coding 10:43159110 20665 340_2_1 SeqId_3516_60 'SDF-1 chr10:44893756_C_T$SeqId_3516_60 1 chr10:44893756_C_T rs1023264 cis 10 44893756 T C 0.6648 -0.133 0.014 2.05e-21 'Stromal cell-derived factor 1 ENSG00000107562 'CXCL12 regulatory_region_variant ENSG00000107562 ENSG00000107562 'CXCL12 3 novel specific_protein -0.15287 0.066635 0.0222075168345075 yes CXCL12 Olink IMMUNE RESPONSE(v.3202) CXCL12 chr10 44370165 44386493 -1 6387 protein_coding 10:44398308 11815 340_2_2 SeqId_10620_21 'PSP-94 chr10:47546323_C_T$SeqId_10620_21 1 chr10:47546323_C_T rs6602880 trans 10 47546323 T C 0.663 0.4571 0.0139 8.88e-239 'Beta-microseminoprotein ENSG00000138294 'MSMB intergenic_variant 0.467995 10:51465920_G_A ENSG00000204169 'AGAP7 missense_variant none ENSG00000012779|ENSG00000198250|ENSG00000215044|ENSG00000224402|ENSG00000243536 'ALOX5 1 known specific_protein 0.49932 0.061575 4.21696503428582e-15 yes MSMB Olink DEVELOPMENT(v.3511) MSMB chr10 46033307 46048180 -1 4477 protein_coding 10:46175087 126907 340_2_3 SeqId_3212_30 'ASAH2 chr10:48003992_C_T$SeqId_3212_30 1 chr10:48003992_C_T rs142685947 trans 10 48003992 T C 0.4294 0.3365 0.0146 7.63e-118 'Neutral ceramidase ENSG00000188611 'ASAH2 missense_variant ENSG00000072444 ENSG00000072444 ' 3 known specific_protein 0.34891 0.060874 1.75873335413557e-08 yes N-CDase Olink NEUROLOGY(v.8011) ASAH2 chr10 50182778 50279720 -1 56624 protein_coding 10:50189523 90197 341_1_1 SeqId_10620_21 'PSP-94 chr10:51549496_C_T$SeqId_10620_21 1 chr10:51549496_C_T rs10993994 cis 10 51549496 T C 0.3964 -0.9238 0.0093 1.94e-2145 'Beta-microseminoprotein ENSG00000138294 'MSMB upstream_gene_variant ENSG00000138294 ENSG00000138294 ' 3 known suggestive_specific_pathway -0.94107 0.041075 3.16227766016838e-79 yes MSMB Olink DEVELOPMENT(v.3511) MSMB chr10 46033307 46048180 -1 4477 protein_coding 10:46046326 1854 341_1_2 SeqId_3212_30 'ASAH2 chr10:52018482_A_G$SeqId_3212_30 1 chr10:52018482_A_G rs2842126 cis 10 52018482 A G 0.2058 -0.6184 0.0152 7.40e-362 'Neutral ceramidase ENSG00000188611 'ASAH2 intergenic_variant ENSG00000188611 ENSG00000188611 'ASAH2 3 known specific_protein -0.66391 0.075822 3.47536161443206e-17 yes N-CDase Olink NEUROLOGY(v.8011) ASAH2 chr10 50182778 50279720 -1 56624 protein_coding 10:50258722 20998 342_1_1 SeqId_3535_84 'DKK1 chr10:54119880_G_T$SeqId_3535_84 1 chr10:54119880_G_T rs7097068 cis 10 54119880 T G 0.5568 0.1616 0.0127 2.62e-37 'Dickkopf-related protein 1 ENSG00000107984 'DKK1 intergenic_variant ENSG00000107984 ENSG00000107984 'DKK1 5 known specific_pathway 0.095529 0.065897 0.147801894224804 no Dkk-1 Olink CARDIOVASCULAR II(v.5004) DKK1 chr10 52314281 52318042 1 22943 protein_coding 10:52360120 45839 342_1_3 SeqId_3000_66 'MBL chr10:54536839_G_T$SeqId_3000_66 1 chr10:54536839_G_T rs7899547 cis 10 54536839 T G 0.3476 -0.9006 0.0117 2.55e-1289 'Mannose-binding protein C ENSG00000165471 'MBL2 intergenic_variant 0.307508 rs1800450 ENSG00000165471 'MBL2 missense_variant ENSG00000165471 ENSG00000165471 'MBL2 3 known specific_pathway -0.81781 0.060042 5.40754322945577e-36 yes MBL2 Olink CARDIOMETABOLIC(v.3602) MBL2 chr10 52765380 52772784 -1 4153 protein_coding 10:52777079 4295 343_1_2 SeqId_3535_84 'DKK1 chr10:65027610_A_T$SeqId_3535_84 1 chr10:65027610_A_T rs10761731 trans 10 65027610 A T 0.5808 -0.1375 0.0127 3.4e-27 'Dickkopf-related protein 1 ENSG00000107984 'DKK1 intron_variant 0.787721 rs1935 ENSG00000171988 'JMJD1C missense_variant none ENSG00000171988 'JMJD1C 3 known unspecific_effect -0.22299 0.062989 0.00043873269513253 yes Dkk-1 Olink CARDIOVASCULAR II(v.5004) DKK1 chr10 52314281 52318042 1 22943 protein_coding 10:63267850 10953569 344_1_1 SeqId_19251_56 'Platelet proteoglycan chr10:70856963_C_G$SeqId_19251_56 1 chr10:70856963_C_G rs67852477 cis 10 70856963 C G 0.9882 1.052 0.0607 3.16e-67 'Serglycin ENSG00000122862 'SRGN missense_variant ENSG00000122862 ENSG00000122862 'SRGN 3 novel unspecific_effect SRGN chr10 69088103 69104805 1 5552 protein_coding 10:69097207 9104 344_1_4 SeqId_19293_6 'VP26A chr10:70941700_A_G$SeqId_19293_6 1 chr10:70941700_A_G rs10998625 cis 10 70941700 A G 0.7659 0.252 0.0149 5.11e-64 'Vacuolar protein sorting-associated protein 26A ENSG00000122958 'VPS26A intron_variant ENSG00000122958 ENSG00000122958 'VPS26A 3 novel specific_protein VPS26A chr10 69123512 69174412 1 9559 protein_coding 10:69181944 58432 344_1_7 SeqId_17726_3 'SAR1A chr10:71912664_A_G$SeqId_17726_3 1 chr10:71912664_A_G rs4746023 cis 10 71912664 A G 0.4424 0.1762 0.0122 2.86e-47 'GTP-binding protein SAR1a ENSG00000079332 'SAR1A intron_variant ENSG00000079332 ENSG00000079332 'SAR1A 3 known suggestive_specific_pathway SAR1A chr10 70147289 70170523 -1 56681 protein_coding 10:70152908 17615 344_1_8 SeqId_5021_13 'PPase chr10:72005190_A_G$SeqId_5021_13 1 chr10:72005190_A_G rs10823500 cis 10 72005190 A G 0.6275 -0.2744 0.0127 1.84e-103 'Inorganic pyrophosphatase ENSG00000180817 'PPA1 downstream_gene_variant ENSG00000180817 ENSG00000180817 'PPA1 3 known suggestive_specific_pathway PPA1 chr10 70202835 70233911 -1 5464 protein_coding 10:70245434 11523 344_2_1 SeqId_11313_100 'PHS chr10:72583601_C_G$SeqId_11313_100 1 chr10:72583601_C_G rs55763022 cis 10 72583601 C G 0.0395 -0.3007 0.0336 3.95e-19 'Pterin-4-alpha-carbinolamine dehydratase ENSG00000166228 'PCBD1 intron_variant ENSG00000166228 ENSG00000166228 'PCBD1 3 known specific_protein PCBD1 chr10 70882280 70888565 -1 5092 protein_coding 10:70823845 64720 344_2_3 SeqId_15394_79 'UNC5B chr10:73021817_C_T$SeqId_15394_79 1 chr10:73021817_C_T rs78747281 cis 10 73021817 T C 0.0507 0.2109 0.0304 4.15e-12 'Netrin receptor UNC5B ENSG00000107731 'UNC5B intron_variant ENSG00000107731 ENSG00000107731 'UNC5B 3 novel specific_protein UNC5B chr10 71212570 71302864 1 219699 protein_coding 10:71262060 49490 344_3_1 SeqId_11531_24 'GI24 chr10:73531069_A_G$SeqId_11531_24 1 chr10:73531069_A_G rs10762477 cis 10 73531069 A G 0.8583 -0.7208 0.0174 4.45e-375 'V-type immunoglobulin domain-containing suppressor of T-cell activation ENSG00000107738 'C10orf54 intron_variant 0.100166 rs3747862 ENSG00000107738 'C10orf54 missense_variant ENSG00000107738 ENSG00000107738 'VSIR 3 known unspecific_effect VSIR chr10 71747556 71773520 -1 64115 protein_coding 10:71771312 2208 344_3_1 SeqId_14123_34 'GI24 chr10:73530977_A_C$SeqId_14123_34 1 chr10:73530977_A_C rs10762476 cis 10 73530977 A C 0.1418 0.861 0.017 1.54e-559 'V-type immunoglobulin domain-containing suppressor of T-cell activation ENSG00000107738 'C10orf54 intron_variant 0.100099 rs3747862 ENSG00000107738 'C10orf54 missense_variant ENSG00000107738 ENSG00000107738 'VSIR 3 known unspecific_effect VSIR chr10 71747556 71773520 -1 64115 protein_coding 10:71771220 2300 344_3_5 SeqId_6207_10 'prosaposin chr10:73598191_A_G$SeqId_6207_10 1 chr10:73598191_A_G rs2394843 cis 10 73598191 A G 0.5434 -0.3568 0.013 5.4e-165 'Prosaposin ENSG00000197746 'PSAP intron_variant ENSG00000197746 ENSG00000197746 'PSAP 3 known suggestive_specific_pathway PSAP chr10 71816298 71851251 -1 5660 protein_coding 10:71838434 12817 344_3_7 SeqId_5491_12 'Testican-2 chr10:73844563_A_G$SeqId_5491_12 1 chr10:73844563_A_G rs1668153 cis 10 73844563 A G 0.5492 -0.1679 0.0129 9.93e-39 'Testican-2 ENSG00000107742 'SPOCK2 intron_variant ENSG00000107742 ENSG00000107742 'SPOCK2 3 known specific_protein SPOCK2 chr10 72059034 72089032 -1 9806 protein_coding 10:72084805 4227 344_3_8 SeqId_8006_12 'DJB12 chr10:74100642_A_G$SeqId_8006_12 1 chr10:74100642_A_G rs9416018 cis 10 74100642 A G 0.6204 -0.1057 0.0135 6.08e-15 'DnaJ homolog subfamily B member 12 ENSG00000148719 'DNAJB12 intron_variant ENSG00000148719 ENSG00000148719 'DNAJB12 3 novel specific_protein DNAJB12 chr10 72332830 72355149 -1 54788 protein_coding 10:72340884 14265 344_3_9 SeqId_9380_2 'sPLA(2)-XIII chr10:74632924_C_T$SeqId_9380_2 1 chr10:74632924_C_T rs10823949 cis 10 74632924 T C 0.0478 -0.2677 0.0315 2.14e-17 'Group XIIB secretory phospholipase A2-like protein ENSG00000138308 'PLA2G12B intron_variant ENSG00000138308 ENSG00000138308 'PLA2G12B 3 known specific_protein PLA2G12B chr10 72934762 72954806 -1 84647 protein_coding 10:72873166 81640 344_4_1 SeqId_7144_234 'KAZD1 chr10:75672607_D_I$SeqId_7144_234 1 chr10:75672607_D_I rs61567551 trans 10 75672607 D I 0.445 0.1554 0.0139 4.35e-29 'Kazal-type serine protease inhibitor domain-containing protein 1 ENSG00000107821 'KAZALD1 intron_variant 0.434339 rs2227564 ENSG00000122861 'PLAU missense_variant none ENSG00000222047 ' 1 known unspecific_effect KAZALD1 chr10 101061989 101068131 1 81621 protein_coding 10:73912850 27149139 344_4_2 SeqId_4158_54 'uPA chr10:75672475_A_G$SeqId_4158_54 1 chr10:75672475_A_G rs2227560 cis 10 75672475 A G 0.265 0.3302 0.0144 1.35e-116 'Urokinase-type plasminogen activator ENSG00000122861 'PLAU intron_variant 0.91377 rs2227564 ENSG00000122861 'PLAU missense_variant ENSG00000122861 ENSG00000122861 'PLAU 3 known unspecific_effect 0.24088 0.074212 0.00125227583459714 yes uPA Olink CARDIOVASCULAR III(v.6112) PLAU chr10 73909177 73917496 1 5328 protein_coding 10:73912717 3540 344_4_4 SeqId_6525_17 'DUSP13 chr10:76845873_C_G$SeqId_6525_17 1 chr10:76845873_C_G rs11001291 cis 10 76845873 C G 0.3656 -0.1472 0.0137 8.54e-27 'Dual specificity protein phosphatase 13 isoform A ENSG00000079393 'DUSP13 downstream_gene_variant 0.806651 rs3088142 ENSG00000079393 'DUSP13 missense_variant ENSG00000079393 ENSG00000079393 'DUSP13 3 known specific_protein DUSP13 chr10 75094432 75109221 -1 51207 protein_coding 10:75086115 23106 345_1_2 SeqId_19590_46 'SP-D chr10:81749858_C_T$SeqId_19590_46 1 chr10:81749858_C_T rs11201057 cis 10 81749858 T C 0.6643 -0.5654 0.0132 7.43e-401 'Pulmonary surfactant-associated protein D ENSG00000133661 'SFTPD intergenic_variant 0.209401 rs2243639 ENSG00000133661 'SFTPD missense_variant ENSG00000133661 ENSG00000133661 'SFTPD 3 known specific_protein -0.062666 0.069046 0.36453564425778 no PSP-D Olink CARDIOVASCULAR III(v.6112) SFTPD chr10 79937467 79982614 -1 6441 protein_coding 10:79990102 7488 345_1_3 SeqId_17513_11 'ANX11 chr10:81951635_A_G$SeqId_17513_11 1 chr10:81951635_A_G rs2819946 cis 10 81951635 A G 0.5759 0.2394 0.0132 1.25e-73 'Annexin A11 ENSG00000122359 'ANXA11 intron_variant 0.997034 rs1049550 ENSG00000122359 'ANXA11 missense_variant ENSG00000122359 ENSG00000122359 'ANXA11 3 known suggestive_specific_pathway 0.13035 0.06373 0.0413618542572662 yes ANXA11 Olink METABOLISM(v.3402) ANXA11 chr10 80150889 80205572 -1 311 protein_coding 10:80191879 13693 345_1_4 SeqId_13423_94 'CJ058 chr10:82169598_C_G$SeqId_13423_94 1 chr10:82169598_C_G rs9787439 cis 10 82169598 C G 0.523 0.1325 0.0134 3.61e-23 'Redox-regulatory protein FAM213A ENSG00000122378 'FAM213A intron_variant ENSG00000122378 ENSG00000122378 'PRXL2A 3 known suggestive_specific_pathway PRXL2A chr10 80407829 80437115 1 84293 protein_coding 10:80409842 2013 346_1_1 SeqId_5586_66 'MINP1 chr10:89275057_A_T$SeqId_5586_66 1 chr10:89275057_A_T rs12356259 cis 10 89275057 A T 0.4711 -0.1211 0.0131 3.04e-20 'Multiple inositol polyphosphate phosphatase 1 ENSG00000107789 'MINPP1 intron_variant ENSG00000107789 ENSG00000107789 'MINPP1 3 known specific_protein MINPP1 chr10 87504875 87553461 1 9562 protein_coding 10:87515300 10425 346_1_4 SeqId_8097_77 'LIPN chr10:90525792_C_T$SeqId_8097_77 1 chr10:90525792_C_T rs10509554 cis 10 90525792 T C 0.3107 0.7464 0.0126 1.34e-764 'Lipase member N ENSG00000204020 'LIPN intron_variant 0.161021 rs10788611 ENSG00000204020 'LIPN missense_variant ENSG00000204020 ENSG00000204020 'LIPN 3 known unspecific_effect LIPN chr10 88759982 88779626 1 643418 protein_coding 10:88766035 6053 346_1_5 SeqId_12401_3 'STALP chr10:90623372_A_C$SeqId_12401_3 1 chr10:90623372_A_C rs1147606 cis 10 90623372 A C 0.5199 0.2549 0.0126 2.78e-91 'AMSH-like protease ENSG00000138134 'STAMBPL1 intergenic_variant 0.163235 rs12254856 ENSG00000138134 'STAMBPL1 missense_variant ENSG00000138134 ENSG00000138134 'STAMBPL1 3 novel unspecific_effect STAMBPL1 chr10 88879734 88975153 1 57559 protein_coding 10:88863615 16119 346_1_6 SeqId_9459_7 'Fas, soluble chr10:90768965_A_G$SeqId_9459_7 1 chr10:90768965_A_G rs7911226 cis 10 90768965 A G 0.691 0.3328 0.0137 5.92e-131 'Tumor necrosis factor receptor superfamily member 6 ENSG00000026103 'FAS intron_variant ENSG00000026103 ENSG00000026103 'FAS 3 known specific_protein 0.21532 0.062351 0.000602282161014634 yes FAS Olink CARDIOVASCULAR III(v.6112) FAS chr10 88953813 89029605 1 355 protein_coding 10:89009208 55395 346_1_7 SeqId_5392_73 'Fas, soluble chr10:90782973_A_G$SeqId_5392_73 1 chr10:90782973_A_G rs10887883 cis 10 90782973 A G 0.4105 0.1837 0.0128 9.04e-47 'Tumor necrosis factor receptor superfamily member 6 ENSG00000026103 'FAS intergenic_variant ENSG00000026103 ENSG00000026103 'FAS 3 known specific_protein FAS chr10 88953813 89029605 1 355 protein_coding 10:89023216 69403 346_2_2 SeqId_13642_90 'CIG49 chr10:91102098_C_G$SeqId_13642_90 1 chr10:91102098_C_G rs2274878 cis 10 91102098 C G 0.7573 0.1338 0.0152 1.43e-18 'Interferon-induced protein with tetratricopeptide repeats 3 ENSG00000119917 'IFIT3 downstream_gene_variant ENSG00000119917 ENSG00000119917 'IFIT3 3 known specific_protein IFIT3 chr10 89327307 89377473 1 3437 protein_coding 10:89342341 15034 347_1_2 SeqId_11219_95 'FGFP3 chr10:93665468_D_I$SeqId_11219_95 1 chr10:93665468_D_I rs58519543 cis 10 93665468 D I 0.6837 0.4048 0.0142 2.3e-179 'Fibroblast growth factor-binding protein 3 ENSG00000174721 'FGFBP3 downstream_gene_variant 0.705446 rs1107947 ENSG00000174721 'FGFBP3 missense_variant ENSG00000174721 ENSG00000174721 'FGFBP3 3 known specific_protein FGFBP3 chr10 91906584 91909486 -1 143282 protein_coding 10:91905712 3774 347_1_3 SeqId_3197_70 'IDE chr10:94284001_A_G$SeqId_3197_70 1 chr10:94284001_A_G rs11187046 cis 10 94284001 A G 0.6669 0.1062 0.014 3.65e-14 'Insulin-degrading enzyme ENSG00000119912 'IDE intron_variant ENSG00000119912 ENSG00000119912 'IDE 3 novel specific_protein IDE chr10 92451684 92574096 -1 3416 protein_coding 10:92524244 49852 347_1_4 SeqId_15633_6 'RBP chr10:95360027_A_C$SeqId_15633_6 1 chr10:95360027_A_C rs36014035 cis 10 95360027 A C 0.6206 0.1366 0.0136 7.85e-24 'Retinol-binding protein 4 ENSG00000138207 'RBP4 intron_variant ENSG00000138207 ENSG00000138207 'RBP4 3 known specific_protein RBP4 chr10 93591687 93601744 -1 5950 protein_coding 10:93600270 1474 348_1_1 SeqId_11428_31 'PDLI1 chr10:97053775_G_T$SeqId_11428_31 1 chr10:97053775_G_T rs1328599 cis 10 97053775 T G 0.9201 -0.2004 0.0249 8.38e-16 'PDZ and LIM domain protein 1 ENSG00000107438 'PDLIM1 upstream_gene_variant ENSG00000107438 ENSG00000107438 'PDLIM1 3 novel specific_protein PDLIM1 chr10 95237572 95291012 -1 9124 protein_coding 10:95294018 3006 348_1_2 SeqId_7999_23 'CD39 chr10:97621266_A_G$SeqId_7999_23 1 chr10:97621266_A_G rs11598475 cis 10 97621266 A G 0.3398 0.1456 0.0135 3.65e-27 'Ectonucleoside triphosphate diphosphohydrolase 1 ENSG00000138185 'ENTPD1 intron_variant ENSG00000138185 ENSG00000138185 'ENTPD1 3 known specific_protein ENTPD1 chr10 95711779 95877266 1 953 protein_coding 10:95861509 149730 349_1_1 SeqId_5632_6 'CRAC1 chr10:99642362_A_C$SeqId_5632_6 1 chr10:99642362_A_C rs684225 cis 10 99642362 A C 0.4185 -0.3991 0.0125 5.34e-224 'Cartilage acidic protein 1 ENSG00000095713 'CRTAC1 intron_variant ENSG00000095713 ENSG00000095713 'CRTAC1 3 known specific_protein -0.17013 0.062376 0.00661302249481767 yes CRTAC1 Olink CARDIOMETABOLIC(v.3602) CRTAC1 chr10 97865000 98030828 -1 55118 protein_coding 10:97882605 148223 35_1_1 SeqId_15503_15 'Lefty-A chr1:226082425_A_G$SeqId_15503_15 1 chr1:226082425_A_G rs1223245 cis 1 226082425 A G 0.6285 0.2039 0.0125 1.32e-59 'Left-right determination factor 2 ENSG00000143768 'LEFTY2 intron_variant ENSG00000143768 ENSG00000143768 'LEFTY2 3 novel unspecific_effect LEFTY2 chr1 225936598 225941383 -1 7044 protein_coding 1:225894725 46658 35_1_1 SeqId_15503_20 'Lefty-A chr1:226082425_A_G$SeqId_15503_20 1 chr1:226082425_A_G rs1223245 cis 1 226082425 A G 0.6286 0.6435 0.0121 1.04e-616 'Left-right determination factor 2 ENSG00000143768 'LEFTY2 intron_variant ENSG00000143768 ENSG00000143768 'LEFTY2 3 novel unspecific_effect LEFTY2 chr1 225936598 225941383 -1 7044 protein_coding 1:225894725 46658 350_1_1 SeqId_11219_95 'FGFP3 chr10:101889964_C_T$SeqId_11219_95 1 chr10:101889964_C_T rs72840032 trans 10 101889964 T C 0.0473 -0.3858 0.0317 4.23e-34 'Fibroblast growth factor-binding protein 3 ENSG00000174721 'FGFBP3 regulatory_region_variant 0.985158 rs61751507 ENSG00000120054 'CPN1 missense_variant ENSG00000120054 ENSG00000120054 'CPN1 3 known unspecific_effect FGFBP3 chr10 91906584 91909486 -1 143282 protein_coding 10:100130207 8220721 350_1_1 SeqId_3896_5 'Phosphoglycerate mutase 1 chr10:101889964_C_T$SeqId_3896_5 1 chr10:101889964_C_T rs72840032 trans 10 101889964 T C 0.0472 0.2614 0.0308 1.93e-17 'Phosphoglycerate mutase 1 ENSG00000171314 'PGAM1 regulatory_region_variant 0.985158 rs61751507 ENSG00000120054 'CPN1 missense_variant ENSG00000120054 ENSG00000120054 'CPN1 3 known unspecific_effect PGAM1 chr10 97426191 97433444 1 5223 protein_coding 10:100130207 2704016 351_2_1 SeqId_12571_14 'ARL3 chr10:104474046_D_I$SeqId_12571_14 1 chr10:104474046_D_I rs71019606 cis 10 104474046 D I 0.1318 0.3449 0.0189 8.79e-75 'ADP-ribosylation factor-like protein 3 ENSG00000138175 'ARL3 5_prime_UTR_variant ENSG00000138175 ENSG00000138175 'ARL3 3 novel specific_protein ARL3 chr10 102673731 102714397 -1 403 protein_coding 10:102714290 107 351_2_2 SeqId_11288_26 '5NTC chr10:104934396_D_I$SeqId_11288_26 1 chr10:104934396_D_I rs35243673 cis 10 104934396 D I 0.2974 0.1664 0.0134 3.25e-35 'Cytosolic purine 5'-nucleotidase ENSG00000076685 'NT5C2 intron_variant 0.379962 rs10883841 ENSG00000076685 'NT5C2 missense_variant ENSG00000076685 ENSG00000076685 'NT5C2 3 novel suggestive_specific_pathway NT5C2 chr10 103087185 103277605 -1 22978 protein_coding 10:103174640 102965 351_2_3 SeqId_12436_84 'GST omega-1 chr10:106028154_A_G$SeqId_12436_84 1 chr10:106028154_A_G rs45596840 cis 10 106028154 A G 0.3141 -0.9578 0.011 4.22e-1649 'Glutathione S-transferase omega-1 ENSG00000148834 'GSTO1 upstream_gene_variant 0.995355 rs4925 ENSG00000148834 'GSTO1 missense_variant ENSG00000148834 ENSG00000148834 'GSTO1 3 known specific_protein GSTO1 chr10 104235356 104267459 1 9446 protein_coding 10:104268396 33040 353_1_3 SeqId_7128_9 'VWA2 chr10:115899540_C_T$SeqId_7128_9 1 chr10:115899540_C_T rs35060624 cis 10 115899540 T C 0.0867 0.3254 0.0246 6.18e-40 'von Willebrand factor A domain-containing protein 2 ENSG00000165816 'VWA2 intron_variant 0.268245 rs9664945 ENSG00000165816 'VWA2 missense_variant ENSG00000165816 ENSG00000165816 'VWA2 3 known specific_protein VWA2 chr10 114239254 114294489 1 340706 protein_coding 10:114139781 99473 354_1_1 SeqId_3314_74 'GFRa-1 chr10:117986910_A_G$SeqId_3314_74 1 chr10:117986910_A_G rs1079261 cis 10 117986910 A G 0.2979 0.2252 0.0138 1.78e-59 'GDNF family receptor alpha-1 ENSG00000151892 'GFRA1 intron_variant ENSG00000151892 ENSG00000151892 'GFRA1 3 known specific_protein 0.1556 0.067289 0.0211787342072371 yes GFR-alpha-1 Olink NEUROLOGY(v.8011) GFRA1 chr10 116056925 116276803 -1 2674 protein_coding 10:116227398 49405 354_1_2 SeqId_6627_25 'LIPR1 chr10:118358659_C_T$SeqId_6627_25 1 chr10:118358659_C_T rs2915762 cis 10 118358659 T C 0.5058 0.1307 0.0135 4.89e-22 'Inactive pancreatic lipase-related protein 1 ENSG00000187021 'PNLIPRP1 intron_variant ENSG00000187021 ENSG00000187021 'PNLIPRP1 3 known suggestive_specific_pathway PNLIPRP1 chr10 116590385 116609175 1 5407 protein_coding 10:116599147 8762 354_1_3 SeqId_15471_29 'LIPR2 chr10:118398046_A_C$SeqId_15471_29 1 chr10:118398046_A_C rs7910135 cis 10 118398046 A C 0.5211 0.9976 0.0098 5.32e-2253 'Pancreatic lipase-related protein 2 ENSG00000266200 'PNLIPRP2 intron_variant ENSG00000266200 ENSG00000266200 ' 3 known specific_protein PNLIPRP2 chr10 116620953 116645143 1 5408 polymorphic_pseudogene 10:116638535 17582 355_1_2 SeqId_8358_30 'Peroxiredoxin-3 chr10:120950640_A_G$SeqId_8358_30 1 chr10:120950640_A_G rs7894367 cis 10 120950640 A G 0.6764 0.1125 0.0135 8.35e-17 'Thioredoxin-dependent peroxide reductase, mitochondrial ENSG00000165672 'PRDX3 regulatory_region_variant ENSG00000165672 ENSG00000165672 'PRDX3 3 novel suggestive_specific_pathway 0.21158 0.065877 0.00140701912289033 yes PRDX3 Olink IMMUNE RESPONSE(v.3202) PRDX3 chr10 119167720 119178812 -1 10935 protein_coding 10:119191128 12316 356_2_2 SeqId_12459_13 'PKHA1 chr10:124060802_A_G$SeqId_12459_13 1 chr10:124060802_A_G rs10788274 cis 10 124060802 A G 0.528 -0.5247 0.0124 2.95e-391 'Pleckstrin homology domain-containing family A member 1 ENSG00000107679 'PLEKHA1 intron_variant ENSG00000107679 ENSG00000107679 'PLEKHA1 3 novel specific_protein PLEKHA1 chr10 122374696 122432354 1 59338 protein_coding 10:122301287 73409 356_2_3 SeqId_15594_47 'HTRA1 chr10:124202034_G_T$SeqId_15594_47 1 chr10:124202034_G_T rs76579910 cis 10 124202034 T G 0.0639 -0.2851 0.0267 1.07e-26 'Serine protease HTRA1 ENSG00000166033 'HTRA1 regulatory_region_variant ENSG00000166033 ENSG00000166033 'HTRA1 3 novel suggestive_specific_pathway HTRA1 chr10 122458551 122514907 1 5654 protein_coding 10:122442518 16033 356_2_5 SeqId_17403_14 'acyl-Coenzyme A dehydrogenase chr10:124798683_A_T$SeqId_17403_14 1 chr10:124798683_A_T rs7913063 cis 10 124798683 A T 0.9139 -0.6526 0.0223 2.59e-188 'Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ENSG00000196177 'ACADSB intron_variant ENSG00000196177 ENSG00000196177 'ACADSB 3 novel specific_protein ACADSB chr10 123008979 123058290 1 36 protein_coding 10:123039167 30188 356_2_6 SeqId_4469_78 'ST4S6 chr10:125865777_G_T$SeqId_4469_78 1 chr10:125865777_G_T rs9422302 cis 10 125865777 T G 0.2621 -0.1584 0.0155 1.21e-24 'Carbohydrate sulfotransferase 15 ENSG00000182022 'CHST15 intergenic_variant ENSG00000182022 ENSG00000182022 'CHST15 3 novel specific_protein CHST15 chr10 124007668 124093598 -1 51363 protein_coding 10:124106261 12663 357_1_1 SeqId_11248_43 'HEM4 chr10:127505426_A_G$SeqId_11248_43 1 chr10:127505426_A_G rs1935451 cis 10 127505426 A G 0.9119 -0.3426 0.0223 4.0e-53 'Uroporphyrinogen-III synthase ENSG00000188690 'UROS intron_variant ENSG00000188690 ENSG00000188690 'UROS 3 known specific_protein UROS chr10 125784980 125823258 -1 7390 protein_coding 10:125816857 6401 358_1_1 SeqId_16596_25 'GLRX3 chr10:131945252_C_T$SeqId_16596_25 1 chr10:131945252_C_T rs12248841 cis 10 131945252 T C 0.5729 0.1123 0.0126 6.31e-19 'Glutaredoxin-3 ENSG00000108010 'GLRX3 intron_variant 0.475519 rs2274217 ENSG00000108010 'GLRX3 missense_variant ENSG00000108010 ENSG00000108010 'GLRX3 3 novel suggestive_specific_pathway GLRX3 chr10 130136391 130184521 1 10539 protein_coding 10:130146988 10597 359_1_1 SeqId_10959_125 'BET1L chr11:196944_C_T$SeqId_10959_125 1 chr11:196944_C_T rs11604127 cis 11 196944 T C 0.2274 0.5362 0.0149 2.26e-282 'BET1-like protein ENSG00000177951 'BET1L 5_prime_UTR_variant 0.117094 11:209898_I_D ENSG00000177963 'RIC8A inframe_insertion ENSG00000177951 ENSG00000142082|ENSG00000177951 'BET1L|SIRT3 5 novel unspecific_effect BET1L chr11 167784 207399 -1 51272 protein_coding 11:196944 10455 359_1_1 SeqId_17495_141 'SIR3 chr11:196944_C_T$SeqId_17495_141 1 chr11:196944_C_T rs11604127 cis 11 196944 T C 0.2274 0.217 0.0158 3.84e-43 'NAD-dependent protein deacetylase sirtuin-3, mitochondrial ENSG00000142082 'SIRT3 5_prime_UTR_variant 0.117094 11:209898_I_D ENSG00000177963 'RIC8A inframe_insertion ENSG00000142082 ENSG00000142082|ENSG00000177951 'BET1L|SIRT3 5 novel unspecific_effect SIRT3 chr11 215030 236931 -1 23410 protein_coding 11:196944 39987 359_1_1 SeqId_5026_66 'RS3 chr11:196944_C_T$SeqId_5026_66 1 chr11:196944_C_T rs11604127 trans 11 196944 T C 0.2273 0.1367 0.0148 1.92e-20 '40S ribosomal protein S3 ENSG00000149273 'RPS3 5_prime_UTR_variant 0.117094 11:209898_I_D ENSG00000177963 'RIC8A inframe_insertion ENSG00000177947|ENSG00000185627|ENSG00000142082|ENSG00000174885|ENSG00000177951|ENSG00000188076|ENSG00000255026 ENSG00000142082|ENSG00000177951 'BET1L|SIRT3 5 novel unspecific_effect RPS3 chr11 75399515 75422280 1 6188 protein_coding 11:196944 75202571 359_1_2 SeqId_9962_1 'MUCDL chr11:613697_A_G$SeqId_9962_1 1 chr11:613697_A_G rs61877853 cis 11 613697 A G 0.7838 -0.1265 0.0166 2.62e-14 'Cadherin-related family member 5 ENSG00000099834 'CDHR5 intron_variant 0.939605 rs7108757 ENSG00000099834 'CDHR5 missense_variant ENSG00000099834 ENSG00000099834 'CDHR5 3 novel specific_protein CDHR5 chr11 616577 626078 -1 53841 protein_coding 11:613697 12381 359_1_3 SeqId_13621_31 'AP2A2 chr11:948299_A_G$SeqId_13621_31 1 chr11:948299_A_G rs117126836 cis 11 948299 A G 0.0932 0.2022 0.0221 5.5e-20 'AP-2 complex subunit alpha-2 ENSG00000183020 'AP2A2 intron_variant ENSG00000183020 ENSG00000183020 'AP2A2 3 novel specific_protein AP2A2 chr11 924881 1012245 1 161 protein_coding 11:948299 23418 359_2_3 SeqId_9790_28 'BR serine/threonine kinase 2 chr11:1412848_A_G$SeqId_9790_28 1 chr11:1412848_A_G rs7932863 cis 11 1412848 A G 0.2734 0.329 0.0143 1.08e-117 'Serine/threonine-protein kinase BRSK2 ENSG00000174672 'BRSK2 intron_variant ENSG00000174672 ENSG00000174672 'BRSK2 3 novel specific_protein BRSK2 chr11 1389899 1462689 1 9024 protein_coding 11:1391618 1719 359_2_4 SeqId_5508_62 'Cathepsin D chr11:1783757_A_G$SeqId_5508_62 1 chr11:1783757_A_G rs55861089 cis 11 1783757 A G 0.9024 0.4704 0.0216 2.73e-105 'Cathepsin D ENSG00000117984 'CTSD intron_variant 0.796369 rs17571 ENSG00000117984 'CTSD missense_variant ENSG00000117984 ENSG00000117984 'CTSD 3 known unspecific_effect 0.6264 0.08986 1.03992016582906e-11 yes CTSD Olink CARDIOVASCULAR III(v.6112) CTSD chr11 1752752 1764573 -1 1509 protein_coding 11:1762527 2046 36_1_1 SeqId_17325_10 'KGUA chr1:228314350_C_G$SeqId_17325_10 1 chr1:228314350_C_G rs10495278 cis 1 228314350 C G 0.9627 -0.6747 0.0337 3.31e-89 'Guanylate kinase ENSG00000143774 'GUK1 intergenic_variant ENSG00000143774 ENSG00000143774 'GUK1 3 novel specific_protein GUK1 chr1 228139962 228148984 1 2987 protein_coding 1:228126649 13313 36_2_4 SeqId_10615_18 'MYP0 chr1:230232080_A_G$SeqId_10615_18 1 chr1:230232080_A_G rs7529009 trans 1 230232080 A G 0.5955 -0.2137 0.012 3.15e-71 'Myelin protein P0 ENSG00000158887 'MPZ intron_variant ENSG00000143641 ENSG00000143641|ENSG00000228058 'GALNT2 1 novel specific_protein MPZ chr1 161304735 161309968 -1 4359 protein_coding 1:230096333 68786365 36_2_6 SeqId_11277_23 'ATF6A chr1:230415293_C_T$SeqId_11277_23 1 chr1:230415293_C_T rs2273967 trans 1 230415293 T C 0.2424 0.1406 0.0143 6.53e-23 'Cyclic AMP-dependent transcription factor ATF-6 alpha ENSG00000118217 'ATF6 3_prime_UTR_variant ENSG00000143641|ENSG00000069248|ENSG00000135744|ENSG00000135775|ENSG00000143632 ENSG00000069248|ENSG00000135744|ENSG00000135775|ENSG00000143632|ENSG00000143641 'ACTA1|AGT|COG2|GALNT2|NUP133 1 known suggestive_specific_pathway ATF6 chr1 161766298 161977574 1 22926 protein_coding 1:230279547 68513249 36_3_3 SeqId_3484_60 'Angiotensinogen chr1:230851044_C_T$SeqId_3484_60 1 chr1:230851044_C_T rs11122580 cis 1 230851044 T C 0.8908 -0.3835 0.0209 3.18e-75 'Angiotensinogen ENSG00000135744 'AGT upstream_gene_variant 0.177068 rs699 ENSG00000135744 'AGT missense_variant ENSG00000135744 ENSG00000135744 'AGT 3 known specific_protein AGT chr1 230690776 230745576 -1 183 protein_coding 1:230715298 30278 36_3_4 SeqId_8035_6 'CA198 chr1:231002496_C_T$SeqId_8035_6 1 chr1:231002496_C_T rs61826310 cis 1 231002496 T C 0.1704 0.2091 0.0173 1.59e-33 'Uncharacterized protein C1orf198 ENSG00000119280 'C1orf198 intron_variant ENSG00000119280 ENSG00000119280 'C1orf198 3 novel specific_protein C1orf198 chr1 230837119 230869589 -1 84886 protein_coding 1:230866750 2839 36_3_5 SeqId_9901_28 'EGLN1 chr1:231556395_C_T$SeqId_9901_28 1 chr1:231556395_C_T rs1339891 cis 1 231556395 T C 0.1333 0.2112 0.0197 8.62e-27 'Egl nine homolog 1 ENSG00000135766 'EGLN1 intron_variant ENSG00000135766 ENSG00000135766 'EGLN1 3 novel specific_protein 0.17693 0.08744 0.0435712480503084 yes EGLN1 Olink IMMUNE RESPONSE(v.3202) EGLN1 chr1 231363751 231422287 -1 54583 protein_coding 1:231420649 1638 360_1_1 SeqId_19188_21 'NAP2L chr11:2956566_C_T$SeqId_19188_21 1 chr11:2956566_C_T rs12364426 cis 11 2956566 T C 0.2254 -0.2215 0.0146 4.75e-52 'nucleosome assembly protein 1-like 4 ENSG00000205531 'NAP1L4 intergenic_variant ENSG00000205531 ENSG00000205531 'NAP1L4 5 known specific_pathway NAP1L4 chr11 2944431 2992377 -1 4676 protein_coding 11:2935336 57041 360_2_1 SeqId_8916_32 'STIM1 chr11:3887176_C_G$SeqId_8916_32 1 chr11:3887176_C_G rs11030122 cis 11 3887176 C G 0.7013 0.13 0.0142 5.75e-20 'Stromal interaction molecule 1 ENSG00000167323 'STIM1 intron_variant ENSG00000167323 ENSG00000167323 'STIM1 3 novel specific_protein STIM1 chr11 3854527 4093210 1 6786 protein_coding 11:3865946 11419 361_2_1 SeqId_17495_141 'SIR3 chr11:6463088_A_G$SeqId_17495_141 1 chr11:6463088_A_G rs2035675 trans 11 6463088 A G 0.7563 -0.1809 0.0154 1.13e-31 'NAD-dependent protein deacetylase sirtuin-3, mitochondrial ENSG00000142082 'SIRT3 upstream_gene_variant ENSG00000110169|ENSG00000132275|ENSG00000166333|ENSG00000166337 ENSG00000110148|ENSG00000110169|ENSG00000132275|ENSG00000166333|ENSG00000166337|ENSG00000166340 'CCKBR|HPX|ILK|RRP8|TAF10|TPP1 1 known unspecific_effect SIRT3 chr11 215030 236931 -1 23410 protein_coding 11:6441858 6204927 361_2_2 SeqId_17691_1 'TPP1 chr11:6642010_D_I$SeqId_17691_1 1 chr11:6642010_D_I rs72353957 cis 11 6642010 D I 0.373 0.193 0.0137 9.29e-45 'Tripeptidyl-peptidase 1 ENSG00000166340 'TPP1 upstream_gene_variant ENSG00000166340 ENSG00000166340|ENSG00000166341 'DCHS1|TPP1 3 novel suggestive_specific_pathway 0.08425 0.064411 0.191491719978619 no TPP1 Olink DEVELOPMENT(v.3511) TPP1 chr11 6612768 6619448 -1 1200 protein_coding 11:6620780 1332 361_2_3 SeqId_10818_36 'ASM chr11:6415463_A_G$SeqId_10818_36 1 chr11:6415463_A_G rs1050239 cis 11 6415463 A G 0.2405 -0.3905 0.0154 1.91e-141 'Sphingomyelin phosphodiesterase ENSG00000166311 'SMPD1 missense_variant ENSG00000166311 ENSG00000166311 'SMPD1 3 known specific_protein -0.4901 0.067426 1.48251808514595e-12 yes SMPD1 Olink NEUROLOGY(v.8011) SMPD1 chr11 6390440 6394998 1 6609 protein_coding 11:6394233 3793 361_2_4 SeqId_12573_80 'TRIM3 chr11:6493153_C_T$SeqId_12573_80 1 chr11:6493153_C_T rs60616451 cis 11 6493153 T C 0.8271 0.2397 0.0165 1.22e-47 'Tripartite motif-containing protein 3 ENSG00000110171 'TRIM3 intron_variant ENSG00000110171 ENSG00000110171 'TRIM3 3 novel specific_protein TRIM3 chr11 6448613 6474459 -1 10612 protein_coding 11:6471923 2536 361_3_1 SeqId_19143_38 'NB5R2 chr11:7683823_A_G$SeqId_19143_38 1 chr11:7683823_A_G rs201206315 cis 11 7683823 A G 0.114 -0.4615 0.0205 4.3e-112 'NADH-cytochrome b5 reductase 2 ENSG00000166394 'CYB5R2 downstream_gene_variant ENSG00000166394 ENSG00000166394 'CYB5R2 3 novel specific_protein CYB5R2 chr11 7665100 7677222 -1 51700 protein_coding 11:7662592 14630 361_4_1 SeqId_13552_7 'SWP70 chr11:9771687_C_G$SeqId_13552_7 1 chr11:9771687_C_G rs6483656 cis 11 9771687 C G 0.6476 -0.7135 0.0123 2.82e-733 'Switch-associated protein 70 ENSG00000133789 'SWAP70 3_prime_UTR_variant 0.955753 rs415895 ENSG00000133789 'SWAP70 missense_variant ENSG00000133789 ENSG00000133789 'SWAP70 3 known specific_protein SWAP70 chr11 9664077 9752993 1 23075 protein_coding 11:9750140 86063 361_4_2 SeqId_3206_4 'LYVE1 chr11:10647995_A_G$SeqId_3206_4 1 chr11:10647995_A_G rs35468145 cis 11 10647995 A G 0.0412 0.4166 0.0321 1.96e-38 'Lymphatic vessel endothelial hyaluronic acid receptor 1 ENSG00000133800 'LYVE1 missense_variant ENSG00000133800 ENSG00000133800 'LYVE1 3 known specific_protein 0.32441 0.15874 0.0415336405489074 yes LYVE1 Olink CARDIOMETABOLIC(v.3602) LYVE1 chr11 10556966 10611689 -1 10894 protein_coding 11:10626448 14759 361_4_3 SeqId_8255_34 'MRVI1 chr11:10675738_A_G$SeqId_8255_34 1 chr11:10675738_A_G rs10840457 cis 11 10675738 A G 0.316 0.1755 0.0137 8.6e-38 'Protein MRVI1 ENSG00000072952 'MRVI1 intron_variant ENSG00000072952 ENSG00000072952 'IRAG1 3 novel specific_protein IRAG1 chr11 10573091 10693988 -1 10335 protein_coding 11:10654191 39797 361_5_2 SeqId_3607_71 'DKK3 chr11:12038874_A_G$SeqId_3607_71 1 chr11:12038874_A_G rs11022114 cis 11 12038874 A G 0.3213 0.338 0.0144 1.28e-122 'Dickkopf-related protein 3 ENSG00000050165 'DKK3 regulatory_region_variant ENSG00000050165 ENSG00000050165 'DKK3 3 known specific_protein 0.41408 0.064643 3.55222118482319e-10 yes DKK3 Olink DEVELOPMENT(v.3511) DKK3 chr11 11956207 12009769 -1 27122 protein_coding 11:12017327 7558 361_5_3 SeqId_13434_172 'PARVA chr11:12371909_A_T$SeqId_13434_172 1 chr11:12371909_A_T rs4757383 cis 11 12371909 A T 0.9098 -0.2526 0.023 4.37e-28 'Alpha-parvin ENSG00000197702 'PARVA intron_variant ENSG00000197702 ENSG00000197702 'PARVA 3 novel specific_protein PARVA chr11 12377563 12535356 1 55742 protein_coding 11:12350362 27201 362_1_1 SeqId_4297_62 'Spondin-1 chr11:14038621_A_G$SeqId_4297_62 1 chr11:14038621_A_G rs1969539 cis 11 14038621 A G 0.486 0.3611 0.0122 9.02e-192 'Spondin-1 ENSG00000262655 'SPON1 intron_variant,non_coding_transcript_variant ENSG00000262655 ENSG00000262655 'SPON1 3 known specific_protein 0.3303 0.059959 5.88572545261201e-08 yes SPON1 Olink CARDIOVASCULAR III(v.6112) SPON1 chr11 13962723 14268133 1 10418 protein_coding 11:14017074 54351 362_1_2 SeqId_12361_102 'RRAS2 chr11:14456929_A_G$SeqId_12361_102 1 chr11:14456929_A_G rs112170428 cis 11 14456929 A G 0.2492 0.1186 0.0156 2.98e-14 'Ras-related protein R-Ras2 ENSG00000133818 'RRAS2 intergenic_variant ENSG00000133818 ENSG00000133818 'RRAS2 3 novel specific_protein RRAS2 chr11 14277922 14364506 -1 22800 protein_coding 11:14435383 70877 362_1_3 SeqId_17170_15 'CALCB chr11:15073206_D_I$SeqId_17170_15 1 chr11:15073206_D_I rs536318931 cis 11 15073206 D I 0.7336 0.2751 0.015 4.82e-75 'Calcitonin gene-related peptide 2 ENSG00000175868 'CALCB intron_variant ENSG00000175868 ENSG00000175868 'CALCB 3 novel specific_protein CALCB chr11 14904997 15082342 1 797 protein_coding 11:15051661 146664 362_2_2 SeqId_12731_12 'PKHA7 chr11:16885175_A_G$SeqId_12731_12 1 chr11:16885175_A_G rs425325 cis 11 16885175 A G 0.1025 1.0947 0.0194 5.39e-694 'Pleckstrin homology domain-containing family A member 7 ENSG00000166689 'PLEKHA7 intron_variant ENSG00000166689 ENSG00000166689 'PLEKHA7 3 known specific_protein PLEKHA7 chr11 16777297 17014414 -1 144100 protein_coding 11:16863628 150786 362_3_1 SeqId_15515_2 'SAA chr11:18278423_A_C$SeqId_15515_2 1 chr11:18278423_A_C rs11024589 cis 11 18278423 A C 0.9056 0.6928 0.0215 1.11e-227 'Serum amyloid A-1 protein ENSG00000173432 'SAA1 intergenic_variant ENSG00000173432 ENSG00000134339|ENSG00000173432 'SAA1|SAA2 3 known suggestive_specific_pathway SAA1 chr11 18266260 18269977 1 6288 protein_coding 11:18256876 9384 362_3_1 SeqId_18832_65 'SAA2 chr11:18278423_A_C$SeqId_18832_65 1 chr11:18278423_A_C rs11024589 cis 11 18278423 A C 0.9056 0.6126 0.0224 2.17e-164 'Serum amyloid A-2 protein ENSG00000134339 'SAA2 intergenic_variant ENSG00000134339 ENSG00000134339|ENSG00000173432 'SAA1|SAA2 3 known suggestive_specific_pathway SAA2 chr11 18239223 18248668 -1 6289 protein_coding 11:18256876 8208 362_3_3 SeqId_15516_12 'SAA-4 chr11:18248214_A_G$SeqId_15516_12 1 chr11:18248214_A_G rs7117484 cis 11 18248214 A G 0.5255 -0.6788 0.0118 3.66e-721 'Serum amyloid A-4 protein ENSG00000148965 'SAA4 downstream_gene_variant ENSG00000148965 ENSG00000148965 'SAA4 3 novel suggestive_specific_pathway -0.57726 0.056677 3.32659553294003e-22 yes SAA4 Olink CARDIOMETABOLIC(v.3602) SAA4 chr11 18231355 18236802 -1 6291 protein_coding 11:18226667 10135 362_3_4 SeqId_15414_316 'LDHA chr11:18411722_A_G$SeqId_15414_316 1 chr11:18411722_A_G rs111294128 cis 11 18411722 A G 0.9855 0.4574 0.0559 2.72e-16 'L-lactate dehydrogenase A chain ENSG00000134333 'LDHA downstream_gene_variant ENSG00000134333 ENSG00000134333 'LDHA 3 novel unspecific_effect LDHA chr11 18394560 18408425 1 3939 protein_coding 11:18390175 4385 362_3_5 SeqId_9828_86 'LDHC chr11:18462494_A_T$SeqId_9828_86 1 chr11:18462494_A_T rs2643858 cis 11 18462494 A T 0.8767 -0.2204 0.0208 4.08e-26 'L-lactate dehydrogenase C chain ENSG00000166796 'LDHC intron_variant ENSG00000166796 ENSG00000166796 'LDHC 3 known suggestive_specific_pathway LDHC chr11 18412318 18452063 1 3948 protein_coding 11:18440947 28629 362_3_6 SeqId_13044_5 'TS101 chr11:18548183_G_T$SeqId_13044_5 1 chr11:18548183_G_T rs1395319 cis 11 18548183 T G 0.6597 -0.263 0.0131 2.17e-89 'Tumor susceptibility gene 101 protein ENSG00000074319 'TSG101 intron_variant ENSG00000074319 ENSG00000074319 'TSG101 3 known unspecific_effect TSG101 chr11 18468336 18526951 -1 7251 protein_coding 11:18526636 315 363_1_1 SeqId_10630_5 'HTAI2 chr11:20385606_A_G$SeqId_10630_5 1 chr11:20385606_A_G rs10437608 cis 11 20385606 A G 0.5435 0.8508 0.0109 1.05e-1325 'Oxidoreductase HTATIP2 ENSG00000109854 'HTATIP2 intron_variant ENSG00000109854 ENSG00000109854 'HTATIP2 3 novel unspecific_effect HTATIP2 chr11 20363685 20383782 1 10553 protein_coding 11:20364060 375 363_1_1 SeqId_7753_21 'HTAI2 chr11:20386528_D_I$SeqId_7753_21 1 chr11:20386528_D_I rs545361154 cis 11 20386528 D I 0.5384 0.1441 0.0135 1.02e-26 'Oxidoreductase HTATIP2 ENSG00000109854 'HTATIP2 intron_variant ENSG00000109854 ENSG00000109854 'HTATIP2 3 novel unspecific_effect HTATIP2 chr11 20363685 20383782 1 10553 protein_coding 11:20364983 1298 363_1_2 SeqId_12696_166 'ANM3 chr11:20482099_C_G$SeqId_12696_166 1 chr11:20482099_C_G rs10833330 cis 11 20482099 C G 0.4315 0.0912 0.0133 6.94e-12 'Protein arginine N-methyltransferase 3 ENSG00000185238 'PRMT3 intron_variant ENSG00000185238 ENSG00000185238 'PRMT3 3 novel suggestive_specific_pathway PRMT3 chr11 20387558 20509338 1 10196 protein_coding 11:20460553 72995 363_1_3 SeqId_6544_33 'NELL1 chr11:20955270_A_G$SeqId_6544_33 1 chr11:20955270_A_G rs61652119 cis 11 20955270 A G 0.0468 1.0231 0.0299 3.04e-256 'Protein kinase C-binding protein NELL1 ENSG00000165973 'NELL1 intron_variant 0.996268 rs8176786 ENSG00000165973 'NELL1 missense_variant ENSG00000165973 ENSG00000165973 'NELL1 3 known specific_protein NELL1 chr11 20669551 21575686 1 4745 protein_coding 11:20933724 264173 364_1_1 SeqId_14047_78 'BDNF chr11:27777126_G_T$SeqId_14047_78 1 chr11:27777126_G_T rs59579819 cis 11 27777126 T G 0.9753 -0.2994 0.0404 1.35e-13 'Brain-derived neurotrophic factor ENSG00000176697 'BDNF intron_variant,non_coding_transcript_variant ENSG00000176697 ENSG00000176697 'BDNF 3 known unspecific_effect BDNF chr11 27654893 27722058 -1 627 protein_coding 11:27755579 33521 364_1_1 SeqId_2421_7 'BDNF chr11:27777126_G_T$SeqId_2421_7 1 chr11:27777126_G_T rs59579819 cis 11 27777126 T G 0.9753 -0.289 0.0404 8.53e-13 'Brain-derived neurotrophic factor ENSG00000176697 'BDNF intron_variant,non_coding_transcript_variant ENSG00000176697 ENSG00000176697 'BDNF 3 known unspecific_effect BDNF chr11 27654893 27722058 -1 627 protein_coding 11:27755579 33521 364_1_2 SeqId_16304_6 'LGR4 chr11:27391525_C_T$SeqId_16304_6 1 chr11:27391525_C_T rs79076592 cis 11 27391525 T C 0.9864 -0.6509 0.0586 1.24e-28 'Leucine-rich repeat-containing G-protein coupled receptor 4 ENSG00000205213 'LGR4 intron_variant ENSG00000205213 ENSG00000205213 'LGR4 3 novel specific_protein LGR4 chr11 27365961 27472790 -1 55366 protein_coding 11:27369978 102812 365_1_1 SeqId_3032_11 'FSH chr11:30226528_A_G$SeqId_3032_11 1 chr11:30226528_A_G rs11031006 cis 11 30226528 A G 0.1418 -0.1696 0.0147 6.8e-31 'Follicle stimulating hormone ENSG00000135346|ENSG00000131808 'CGA|FSHB intergenic_variant ENSG00000135346|ENSG00000131808 ENSG00000131808|ENSG00000135346 'CGA|FSHB 3 novel specific_protein FSHB chr11 30231014 30235261 1 2488 protein_coding 11:30204981 26033 365_1_2 SeqId_19153_53 'MPPD2 chr11:30608133_A_G$SeqId_19153_53 1 chr11:30608133_A_G rs11031140 cis 11 30608133 A G 0.1967 -0.3984 0.0164 1.54e-130 'Metallophosphoesterase MPPED2 ENSG00000066382 'MPPED2 intron_variant,non_coding_transcript_variant ENSG00000066382 ENSG00000066382 'MPPED2 3 novel specific_protein MPPED2 chr11 30384493 30586872 -1 744 protein_coding 11:30586586 286 366_2_1 SeqId_11145_72 'K154L chr11:33399691_A_G$SeqId_11145_72 1 chr11:33399691_A_G rs2753408 cis 11 33399691 A G 0.45 -0.5322 0.0131 7.91e-361 'UPF0606 protein KIAA1549L ENSG00000110427 'KIAA1549L intergenic_variant ENSG00000110427 ENSG00000110427 'KIAA1549L 3 known specific_protein KIAA1549L chr11 33376108 33674102 1 25758 protein_coding 11:33378145 2037 366_2_2 SeqId_11514_196 'CD59 chr11:33743679_G_T$SeqId_11514_196 1 chr11:33743679_G_T rs704701 cis 11 33743679 T G 0.6852 0.1584 0.0137 5.4e-31 'CD59 glycoprotein ENSG00000085063 'CD59 intron_variant ENSG00000085063 ENSG00000085063 'CD59 3 known specific_protein CD59 chr11 33703010 33736479 -1 966 protein_coding 11:33722133 14346 366_3_1 SeqId_3488_64 'Catalase chr11:34470679_A_G$SeqId_3488_64 1 chr11:34470679_A_G rs769218 cis 11 34470679 A G 0.2238 -0.2901 0.0153 7.93e-80 'Catalase ENSG00000121691 'CAT intron_variant ENSG00000121691 ENSG00000121691 'CAT 3 known specific_protein CAT chr11 34438934 34472060 1 847 protein_coding 11:34449132 10198 366_3_3 SeqId_18319_7 'ODPX chr11:34949918_D_I$SeqId_18319_7 1 chr11:34949918_D_I rs573225161 cis 11 34949918 D I 0.8758 -0.2478 0.019 7.35e-39 'Pyruvate dehydrogenase protein X component, mitochondrial ENSG00000110435 'PDHX intron_variant 0.920631 rs1049306 ENSG00000110435 'PDHX missense_variant ENSG00000110435 ENSG00000110435 'PDHX 3 novel specific_protein PDHX chr11 34915829 35020591 1 8050 protein_coding 11:34928372 12543 367_1_1 SeqId_7921_65 'FJX1 chr11:36074218_A_T$SeqId_7921_65 1 chr11:36074218_A_T rs11033388 cis 11 36074218 A T 0.5824 -0.2157 0.0133 3.9e-59 'Four-jointed box protein 1 ENSG00000179431 'FJX1 intron_variant ENSG00000179431 ENSG00000179431 'FJX1 3 novel specific_protein FJX1 chr11 35618460 35620865 1 24147 protein_coding 11:36052668 434208 368_1_1 SeqId_9369_174 'NGL1 chr11:40305276_C_T$SeqId_9369_174 1 chr11:40305276_C_T 11:40305276_C_T cis 11 40305276 T C 0.5527 -0.1591 0.0129 4.39e-35 'Leucine-rich repeat-containing protein 4C ENSG00000148948 'LRRC4C intron_variant ENSG00000148948 ENSG00000148948 'LRRC4C 3 known specific_protein LRRC4C chr11 40114203 41459773 -1 57689 protein_coding 11:40283726 1176047 369_1_2 SeqId_18401_18 'ALKB3 chr11:43949008_G_T$SeqId_18401_18 1 chr11:43949008_G_T rs2434484 cis 11 43949008 T G 0.6624 0.3642 0.0133 2.67e-165 'Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 ENSG00000166199 'ALKBH3 intron_variant 0.707197 rs1130290 ENSG00000166199 'ALKBH3 missense_variant ENSG00000166199 ENSG00000166199 'ALKBH3 3 novel specific_protein ALKBH3 chr11 43880811 43920274 1 221120 protein_coding 11:43927458 46647 37_1_1 SeqId_17786_5 'GGPPS chr1:235498377_A_G$SeqId_17786_5 1 chr1:235498377_A_G rs116088703 cis 1 235498377 A G 0.1247 0.2425 0.0189 9.35e-38 'Geranylgeranyl pyrophosphate synthase ENSG00000152904 'GGPS1 intron_variant ENSG00000152904 ENSG00000152904 'GGPS1 3 novel specific_protein GGPS1 chr1 235327350 235344532 1 9453 protein_coding 1:235335062 7712 37_1_2 SeqId_11211_7 'TBCE chr1:235595590_C_T$SeqId_11211_7 1 chr1:235595590_C_T rs9793740 cis 1 235595590 T C 0.3668 0.1588 0.0131 1.31e-33 'Tubulin-specific chaperone E ENSG00000116957 'TBCE intron_variant ENSG00000116957 ENSG00000116957 ' 3 known specific_protein TBCE chr1 235367360 235452443 1 6905 protein_coding 1:235432275 64915 37_2_1 SeqId_3213_65 'Nidogen chr1:236230317_A_G$SeqId_3213_65 1 chr1:236230317_A_G rs76183323 cis 1 236230317 A G 0.0118 -0.9176 0.0636 3.31e-47 'Nidogen-1 ENSG00000116962 'NID1 upstream_gene_variant ENSG00000116962 ENSG00000116962 'NID1 4 novel suggestive_specific_pathway -0.44417 0.33356 0.183615779205795 no NID1 Olink CARDIOMETABOLIC(v.3602) NID1 chr1 235975830 236065109 -1 4811 protein_coding 1:236067017 1908 37_2_2 SeqId_7994_41 'ERO1B chr1:236437408_C_G$SeqId_7994_41 1 chr1:236437408_C_G rs2463186 cis 1 236437408 C G 0.6287 0.1035 0.0135 2.0e-14 'ERO1-like protein beta ENSG00000086619 'ERO1LB intron_variant 0.290587 rs2477599 ENSG00000086619 'ERO1LB missense_variant ENSG00000086619 ENSG00000086619 'ERO1B 3 known specific_protein ERO1B chr1 236214681 236282019 -1 56605 protein_coding 1:236274108 7911 37_2_3 SeqId_4909_68 'Galectin-8 chr1:236701105_A_T$SeqId_4909_68 1 chr1:236701105_A_T rs75416658 cis 1 236701105 A T 0.0294 0.3061 0.04 1.88e-14 'Galectin-8 ENSG00000116977 'LGALS8 intron_variant ENSG00000116977 ENSG00000116977 'LGALS8 3 novel specific_protein LGALS8 chr1 236518000 236552981 1 3964 protein_coding 1:236537805 19805 370_1_2 SeqId_2911_27 'Midkine chr11:46527652_A_G$SeqId_2911_27 1 chr11:46527652_A_G rs77817298 cis 11 46527652 A G 0.0125 0.4717 0.0615 1.65e-14 'Midkine ENSG00000110492 'MDK intron_variant ENSG00000110492 ENSG00000110492 'MDK 3 novel specific_protein 0.58231 0.27576 0.0352289743991456 yes MK Olink ONCOLOGY II(v.7002) MDK chr11 46380756 46383837 1 4192 protein_coding 11:46506102 125346 370_1_3 SeqId_4157_2 'Thrombin chr11:46761055_A_G$SeqId_4157_2 1 chr11:46761055_A_G rs1799963 cis 11 46761055 A G 0.0123 0.7824 0.065 2.4e-33 'Thrombin ENSG00000180210 'F2 3_prime_UTR_variant ENSG00000180210 ENSG00000180210 'F2 3 novel suggestive_specific_pathway F2 chr11 46719196 46739506 1 2147 protein_coding 11:46739505 20309 370_1_4 SeqId_19558_10 'LRP4 chr11:46893108_C_T$SeqId_19558_10 1 chr11:46893108_C_T rs2306029 cis 11 46893108 T C 0.4596 0.3914 0.0125 7.6e-215 'Low-density lipoprotein receptor-related protein 4 ENSG00000134569 'LRP4 missense_variant ENSG00000134569 ENSG00000134569 'LRP4 3 novel unspecific_effect LRP4 chr11 46856717 46918642 -1 4038 protein_coding 11:46871557 47085 370_2_1 SeqId_5316_54 'Prothrombin chr11:47117406_G_T$SeqId_5316_54 1 chr11:47117406_G_T rs183830453 cis 11 47117406 T G 0.0133 0.5137 0.0662 8.29e-15 'Prothrombin ENSG00000180210 'F2 intron_variant ENSG00000180210 ENSG00000180210 'F2 3 novel suggestive_specific_pathway F2 chr11 46719196 46739506 1 2147 protein_coding 11:47095855 376659 370_2_2 SeqId_14674_63 'PACN3 chr11:47235263_A_T$SeqId_14674_63 1 chr11:47235263_A_T rs61897858 cis 11 47235263 A T 0.9081 -0.167 0.0226 1.69e-13 'Protein kinase C and casein kinase substrate in neurons protein 3 ENSG00000165912 'PACSIN3 upstream_gene_variant ENSG00000165912 ENSG00000165912 'PACSIN3 3 known specific_pathway PACSIN3 chr11 47177522 47186443 -1 29763 protein_coding 11:47213712 27269 370_2_3 SeqId_8250_2 'PTPRJ chr11:48275826_A_C$SeqId_8250_2 1 chr11:48275826_A_C rs67277976 cis 11 48275826 A C 0.9777 0.3419 0.0453 4.36e-14 'Receptor-type tyrosine-protein phosphatase eta ENSG00000149177 'PTPRJ intergenic_variant ENSG00000149177 ENSG00000149177 'PTPRJ 3 novel specific_protein PTPRJ chr11 47980559 48170839 1 5795 protein_coding 11:48254274 273715 370_2_4 SeqId_5478_50 'PSMA chr11:49248755_C_T$SeqId_5478_50 1 chr11:49248755_C_T rs61886537 cis 11 49248755 T C 0.9487 -0.47 0.0294 2.02e-57 'Glutamate carboxypeptidase 2 ENSG00000086205 'FOLH1 intergenic_variant 0.994158 rs61886492 ENSG00000086205 'FOLH1 missense_variant ENSG00000086205 ENSG00000086205 'FOLH1 3 known specific_protein FOLH1 chr11 49145092 49208638 -1 2346 protein_coding 11:49227203 18565 370_3_1 SeqId_4479_14 'C1-Esterase Inhibitor chr11:50585712_A_T$SeqId_4479_14 1 chr11:50585712_A_T rs117385291 trans 11 50585712 A T 0.0358 -0.2904 0.0394 1.63e-13 'Plasma protease C1 inhibitor ENSG00000149131 'SERPING1 intergenic_variant 0.40413 rs61887097 ENSG00000172154 'OR8I2 stop_gained none none ' known unspecific_effect SERPING1 chr11 57597387 57619171 1 710 protein_coding 11:50626541 6970846 371_1_1 SeqId_5478_50 'PSMA chr11:54973205_C_T$SeqId_5478_50 1 chr11:54973205_C_T rs77572098 trans 11 54973205 T C 0.9353 -0.3762 0.0275 1.82e-42 'Glutamate carboxypeptidase 2 ENSG00000086205 'FOLH1 intergenic_variant 0.627913 rs61887097 ENSG00000172154 'OR8I2 stop_gained none none ' known specific_protein FOLH1 chr11 49145092 49208638 -1 2346 protein_coding 11:55205729 5997091 371_2_1 SeqId_4479_14 'C1-Esterase Inhibitor chr11:57383377_A_G$SeqId_4479_14 1 chr11:57383377_A_G rs11606677 cis 11 57383377 A G 0.2695 -0.8876 0.0124 2.69e-1115 'Plasma protease C1 inhibitor ENSG00000149131 'SERPING1 downstream_gene_variant 0.981468 rs4926 ENSG00000149131 'SERPING1 missense_variant ENSG00000149131 ENSG00000149131 'SERPING1 8 known unspecific_effect SERPING1 chr11 57597387 57619171 1 710 protein_coding 11:57615904 18517 371_2_2 SeqId_9015_1 'PRG3 chr11:57145633_C_T$SeqId_9015_1 1 chr11:57145633_C_T rs7107352 cis 11 57145633 T C 0.887 0.1485 0.021 1.6e-12 'Proteoglycan 3 ENSG00000156575 'PRG3 intron_variant ENSG00000156575 ENSG00000156575 'PRG3 3 known unspecific_effect PRG3 chr11 57376769 57381150 -1 10394 protein_coding 11:57378160 2990 371_3_1 SeqId_19506_6 'GLYAT chr11:58530764_A_C$SeqId_19506_6 1 chr11:58530764_A_C rs2186414 cis 11 58530764 A C 0.178 -0.1878 0.0175 7.44e-27 'Glycine N-acyltransferase ENSG00000149124 'GLYAT upstream_gene_variant 0.768659 rs10896818 ENSG00000149124 'GLYAT missense_variant ENSG00000149124 ENSG00000149124 'GLYAT 3 novel specific_protein GLYAT chr11 58640426 58731974 -1 10249 protein_coding 11:58763291 31317 371_4_3 SeqId_15587_20 'FOLR2 chr11:60152584_A_G$SeqId_15587_20 1 chr11:60152584_A_G rs950802 trans 11 60152584 A G 0.315 0.1129 0.0131 7.53e-18 'Folate receptor beta ENSG00000165457 'FOLR2 synonymous_variant 0.258363 rs4938941 ENSG00000166928 'MS4A14 splice_acceptor_variant ENSG00000166927 ENSG00000166927 'MS4A7 2 novel unspecific_effect FOLR2 chr11 72216601 72221950 1 2350 protein_coding 11:60385111 11831490 371_4_4 SeqId_17672_184 'Gastric intrinsic factor chr11:59610581_A_G$SeqId_17672_184 1 chr11:59610581_A_G rs150884181 cis 11 59610581 A G 0.9898 0.6518 0.0665 1.13e-22 'Gastric intrinsic factor ENSG00000134812 'GIF missense_variant ENSG00000134812 ENSG00000134812 'CBLIF 3 novel specific_protein 0.53318 0.32383 0.1003136424044 no GIF Olink CARDIOVASCULAR II(v.5004) CBLIF chr11 59829273 59845499 -1 2694 protein_coding 11:59843108 2391 371_4_5 SeqId_19614_8 'Holo-TC I chr11:59623378_A_C$SeqId_19614_8 1 chr11:59623378_A_C rs34324219 cis 11 59623378 A C 0.1066 -0.5059 0.0212 2.51e-125 'Transcobalamin-1 ENSG00000134827 'TCN1 missense_variant ENSG00000134827 ENSG00000134827 'TCN1 3 known specific_protein TCN1 chr11 59852800 59866489 -1 6947 protein_coding 11:59855905 10584 371_4_6 SeqId_7871_16 'T132A chr11:60689445_C_T$SeqId_7871_16 1 chr11:60689445_C_T rs555835 cis 11 60689445 T C 0.37 -0.5986 0.0128 2.12e-477 'Transmembrane protein 132A ENSG00000006118 'TMEM132A synonymous_variant 0.309312 rs2469887 ENSG00000006118 'TMEM132A missense_variant ENSG00000006118 ENSG00000006118 'TMEM132A 3 known specific_protein TMEM132A chr11 60924460 60937159 1 54972 protein_coding 11:60921973 2487 371_4_7 SeqId_17672_184 'Gastric intrinsic factor chr11:60970043_C_G$SeqId_17672_184 1 chr11:60970043_C_G rs7951598 trans 11 60970043 C G 0.3495 -0.238 0.0142 4.39e-63 'Gastric intrinsic factor ENSG00000134812 'GIF upstream_gene_variant 0.155222 rs2229177 ENSG00000110448 'CD5 missense_variant ENSG00000229859 ENSG00000229859 'PGA3 1 novel suggestive_specific_pathway -0.26784 0.066611 6.72821715521547e-05 yes GIF Olink CARDIOVASCULAR II(v.5004) CBLIF chr11 59829273 59845499 -1 2694 protein_coding 11:61202571 1357072 371_4_8 SeqId_18313_4 'Asparaginase-like protein 1 chr11:62152807_A_T$SeqId_18313_4 1 chr11:62152807_A_T rs11231069 cis 11 62152807 A T 0.7242 0.355 0.0141 4.24e-140 'Isoaspartyl peptidase/L-asparaginase ENSG00000162174 'ASRGL1 intron_variant ENSG00000162174 ENSG00000162174 'ASRGL1 3 novel specific_protein ASRGL1 chr11 62337448 62393412 1 80150 protein_coding 11:62385335 47887 371_5_1 SeqId_6897_38 'B3GA3 chr11:62383715_C_G$SeqId_6897_38 1 chr11:62383715_C_G rs12794886 cis 11 62383715 C G 0.6933 0.3625 0.0139 2.02e-149 'Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3 ENSG00000149541 'B3GAT3 intron_variant 0.855071 rs13941 ENSG00000204922 'C11orf83 missense_variant ENSG00000149541 ENSG00000149541 'B3GAT3 6 known suggestive_specific_pathway B3GAT3 chr11 62615296 62622154 -1 26229 protein_coding 11:62616243 5911 372_1_1 SeqId_2668_70 'Calpain I chr11:64936719_A_C$SeqId_2668_70 1 chr11:64936719_A_C rs12292693 cis 11 64936719 A C 0.739 0.3254 0.014 1.37e-119 'Calpain I ENSG00000126247|ENSG00000014216 'CAPNS1|CAPN1 upstream_gene_variant 0.380188 rs2282498 ENSG00000187066 'TMEM262 missense_variant ENSG00000126247|ENSG00000014216 ENSG00000014216 'CAPN1 6 known unspecific_effect CAPN1 chr11 65180566 65212006 1 823 protein_coding 11:65169248 11318 372_1_2 SeqId_13545_97 'EIF1A chr11:65765074_A_G$SeqId_13545_97 1 chr11:65765074_A_G rs72930942 cis 11 65765074 A G 0.0248 0.793 0.041 3.06e-83 'Probable RNA-binding protein EIF1AD ENSG00000175376 'EIF1AD 3_prime_UTR_variant 0.985356 rs2276017 ENSG00000175376 'EIF1AD missense_variant ENSG00000175376 ENSG00000175315|ENSG00000175376 'CST6|EIF1AD 3 known suggestive_specific_pathway EIF1AD chr11 65996545 66002176 -1 84285 protein_coding 11:65997603 4573 372_1_2 SeqId_14711_27 'Cystatin M chr11:65757911_D_I$SeqId_14711_27 1 chr11:65757911_D_I rs547347406 cis 11 65757911 D I 0.9762 -0.3132 0.0428 2.61e-13 'Cystatin-M ENSG00000175315 'CST6 intergenic_variant ENSG00000175315 ENSG00000175315|ENSG00000175376 'CST6|EIF1AD 3 known suggestive_specific_pathway CST6 chr11 66012008 66013505 1 1474 protein_coding 11:65990441 21567 372_1_4 SeqId_9802_27 'PLPL2 chr11:64972286_C_G$SeqId_9802_27 1 chr11:64972286_C_G rs10895991 trans 11 64972286 C G 0.0768 0.1704 0.0244 2.83e-12 'Patatin-like phospholipase domain-containing protein 2 ENSG00000177666 'PNPLA2 missense_variant ENSG00000014216 ENSG00000014216 'CAPN1 4 novel unspecific_effect PNPLA2 chr11 818914 825573 1 57104 protein_coding 11:65204815 64385901 372_2_1 SeqId_9212_22 'CATF chr11:66340039_C_T$SeqId_9212_22 1 chr11:66340039_C_T rs4930383 cis 11 66340039 T C 0.7571 -0.2639 0.0154 1.35e-65 'Cathepsin F ENSG00000174080 'CTSF upstream_gene_variant ENSG00000174080 ENSG00000174080 'CTSF 4 known suggestive_specific_pathway CTSF chr11 66563464 66568879 -1 8722 protein_coding 11:66572568 3689 372_2_2 SeqId_13068_139 'CCS chr11:66343860_C_T$SeqId_13068_139 1 chr11:66343860_C_T rs636128 cis 11 66343860 T C 0.4771 -0.1705 0.0135 2.02e-36 'Copper chaperone for superoxide dismutase ENSG00000173992 'CCS intergenic_variant ENSG00000173992 ENSG00000173992 'CCS 3 known specific_protein CCS chr11 66593153 66606019 1 9973 protein_coding 11:66576389 16764 372_2_3 SeqId_13990_1 'pyruvate carboxylase chr11:66583779_G_T$SeqId_13990_1 1 chr11:66583779_G_T rs543191 cis 11 66583779 T G 0.6081 0.0941 0.0136 5.14e-12 'Pyruvate carboxylase, mitochondrial ENSG00000173599 'PC intron_variant ENSG00000173599 ENSG00000173599 'PC 3 known unspecific_effect PC chr11 66848417 66958386 -1 5091 protein_coding 11:66816308 142078 372_2_4 SeqId_4911_49 'Glutathione S-transferase Pi chr11:67376887_C_G$SeqId_4911_49 1 chr11:67376887_C_G rs72932599 cis 11 67376887 C G 0.0908 0.3637 0.0246 2.56e-49 'Glutathione S-transferase P ENSG00000084207 'GSTP1 intron_variant ENSG00000084207 ENSG00000084207 'GSTP1 3 novel specific_protein 0.024504 0.11183 0.826648724547099 no GSTP1 Olink NEURO EXPLORATORY(v.3901) GSTP1 chr11 67583742 67586656 1 2950 protein_coding 11:67609416 25674 372_2_5 SeqId_12940_35 'AL3B1 chr11:67777082_A_C$SeqId_12940_35 1 chr11:67777082_A_C rs2010404 cis 11 67777082 A C 0.2279 0.1507 0.0154 1.33e-22 'Aldehyde dehydrogenase family 3 member B1 ENSG00000006534 'ALDH3B1 intron_variant ENSG00000006534 ENSG00000006534 'ALDH3B1 3 novel specific_protein ALDH3B1 chr11 68008578 68029282 1 221 protein_coding 11:68009612 1034 373_1_1 SeqId_13975_56 'LIPA1 chr11:70316391_A_G$SeqId_13975_56 1 chr11:70316391_A_G rs55678639 cis 11 70316391 A G 0.6529 0.0984 0.0135 3.2e-13 'Liprin-alpha-1 ENSG00000131626 'PPFIA1 3_prime_UTR_variant ENSG00000131626 ENSG00000131626 'PPFIA1 3 novel specific_protein PPFIA1 chr11 70270690 70385312 1 8500 protein_coding 11:70470286 199596 373_2_1 SeqId_15495_9 'FOLR3 chr11:71850156_D_I$SeqId_15495_9 1 chr11:71850156_D_I rs71891516 cis 11 71850156 D I 0.9255 -1.4859 0.0223 9.43e-967 'Folate receptor gamma ENSG00000110203 'FOLR3 frameshift_variant ENSG00000110203 ENSG00000110203 'FOLR3 6 known suggestive_specific_pathway -1.7366 0.098639 6.1376200516479e-54 yes FR-gamma Olink ONCOLOGY II(v.7002) FOLR3 chr11 72114869 72139892 1 2352 protein_coding 11:72139111 24242 374_2_1 SeqId_6086_15 'CRDL2 chr11:74432192_A_G$SeqId_6086_15 1 chr11:74432192_A_G rs551789974 cis 11 74432192 A G 0.9574 0.6425 0.0327 5.95e-86 'Chordin-like protein 2 ENSG00000054938 'CHRDL2 intron_variant 0.131908 rs117526209 ENSG00000077514 'POLD3 missense_variant ENSG00000054938 ENSG00000054938 'CHRDL2 6 known specific_pathway 0.57183 0.1386 4.35311359229638e-05 yes CHRDL2 Olink METABOLISM(v.3402) CHRDL2 chr11 74696429 74731426 -1 25884 protein_coding 11:74721147 10279 374_2_3 SeqId_12643_4 'ARRB1 chr11:75052797_A_C$SeqId_12643_4 1 chr11:75052797_A_C rs562946 cis 11 75052797 A C 0.7308 -0.1126 0.0138 3.64e-16 'Beta-arrestin-1 ENSG00000137486 'ARRB1 intron_variant ENSG00000137486 ENSG00000137486 'ARRB1 3 novel specific_protein ARRB1 chr11 75260122 75351705 -1 408 protein_coding 11:75341753 9952 374_2_4 SeqId_10800_15 'Collagen-binding protein chr11:75292742_A_T$SeqId_10800_15 1 chr11:75292742_A_T rs636418 cis 11 75292742 A T 0.4205 -0.1574 0.0126 4.89e-36 'Serpin H1 ENSG00000149257 'SERPINH1 upstream_gene_variant ENSG00000149257 ENSG00000149257 'SERPINH1 3 novel specific_protein SERPINH1 chr11 75562056 75572783 1 871 protein_coding 11:75581697 19641 375_1_1 SeqId_5722_78 'Prolylcarboxypeptidase chr11:82564294_G_T$SeqId_5722_78 1 chr11:82564294_G_T rs2229437 cis 11 82564294 T G 0.8245 -0.3019 0.0175 5.04e-67 'Lysosomal Pro-X carboxypeptidase ENSG00000137509 'PRCP missense_variant ENSG00000137509 ENSG00000137509 'PRCP 3 known specific_protein -0.15264 0.076669 0.0470543739953181 yes PRCP Olink CARDIOMETABOLIC(v.3602) PRCP chr11 82822936 82970584 -1 5547 protein_coding 11:82853252 117332 376_1_1 SeqId_9263_57 'SIAE chr11:87909193_A_G$SeqId_9263_57 1 chr11:87909193_A_G rs11602163 trans 11 87909193 A G 0.7188 0.0997 0.0143 3.35e-12 'Sialate O-acetylesterase ENSG00000110013 'SIAE upstream_gene_variant ENSG00000123892 ENSG00000123892 'RAB38 1 novel specific_protein SIAE chr11 124633113 124695707 -1 54414 protein_coding 11:88176025 36519682 378_1_1 SeqId_3299_29 'Contactin-5 chr11:97606257_A_C$SeqId_3299_29 1 chr11:97606257_A_C rs2199562 trans 11 97606257 A C 0.3459 -0.0994 0.0141 1.76e-12 'Contactin-5 ENSG00000149972 'CNTN5 intergenic_variant none none ' novel specific_protein CNTN5 chr11 99020949 100358885 1 53942 protein_coding 11:97735257 1285692 379_1_1 SeqId_3299_29 'Contactin-5 chr11:99089041_A_G$SeqId_3299_29 1 chr11:99089041_A_G rs898776 cis 11 99089041 A G 0.924 -0.6852 0.0243 2.25e-175 'Contactin-5 ENSG00000149972 'CNTN5 intron_variant ENSG00000149972 ENSG00000149972 'CNTN5 3 known specific_protein -0.88104 0.10449 4.00866717627303e-16 yes CNTN5 Olink NEUROLOGY(v.8011) CNTN5 chr11 99020949 100358885 1 53942 protein_coding 11:99218310 197361 380_1_1 SeqId_2789_26 'MMP-7 chr11:102401633_A_G$SeqId_2789_26 1 chr11:102401633_A_G rs11568819 cis 11 102401633 A G 0.0645 0.6356 0.0253 2.26e-139 'Matrilysin ENSG00000137673 'MMP7 upstream_gene_variant 0.318085 rs55701929 ENSG00000137673 'MMP7 missense_variant ENSG00000137673 ENSG00000137673 'MMP7 3 known suggestive_specific_pathway 0.82363 0.13499 2.1632165654073e-09 yes MMP7 Olink CARDIOVASCULAR II(v.5004) MMP7 chr11 102520508 102530750 -1 4316 protein_coding 11:102530902 152 380_1_2 SeqId_9172_69 'MMP-8 chr11:102584135_A_G$SeqId_9172_69 1 chr11:102584135_A_G rs35231465 cis 11 102584135 A G 0.0249 -0.93 0.0429 4.34e-104 'Neutrophil collagenase ENSG00000118113 'MMP8 stop_gained ENSG00000118113 ENSG00000118113 'MMP8 3 known suggestive_specific_pathway MMP8 chr11 102711796 102727050 -1 4317 protein_coding 11:102713404 13646 380_1_3 SeqId_8479_4 'MMP-10 chr11:102649482_C_T$SeqId_8479_4 1 chr11:102649482_C_T rs17860955 cis 11 102649482 T C 0.9801 1.0765 0.0466 4.5e-118 'Stromelysin-2 ENSG00000166670 'MMP10 splice_acceptor_variant ENSG00000166670 ENSG00000166670 'MMP10 3 known suggestive_specific_pathway 1.2651 0.17982 6.87068440014232e-12 yes MMP-10 Olink INFLAMMATION(v.3012) MMP10 chr11 102770502 102780628 -1 4319 protein_coding 11:102778751 1877 380_1_4 SeqId_4924_32 'MMP-1 chr11:102697731_A_G$SeqId_4924_32 1 chr11:102697731_A_G rs471994 cis 11 102697731 A G 0.3587 -0.537 0.0129 9.81e-379 'Interstitial collagenase ENSG00000196611 'MMP1 intron_variant,non_coding_transcript_variant ENSG00000196611 ENSG00000196611 'MMP1 3 known suggestive_specific_pathway -0.50923 0.065769 5.79428696426881e-14 yes MMP-1 Olink INFLAMMATION(v.3012) MMP1 chr11 102789401 102798160 -1 4312 protein_coding 11:102827000 28840 380_1_5 SeqId_4496_60 'MMP-12 chr11:102748695_A_G$SeqId_4496_60 1 chr11:102748695_A_G rs17368814 cis 11 102748695 A G 0.8773 0.6627 0.0182 2.4e-289 'Macrophage metalloelastase ENSG00000262406 'MMP12 upstream_gene_variant ENSG00000262406 ENSG00000262406 'MMP12 3 known suggestive_specific_pathway 0.90422 0.084725 5.2239618899912e-24 yes MMP12 Olink CARDIOVASCULAR II(v.5004) MMP12 chr11 102862736 102874982 -1 4321 protein_coding 11:102877965 2983 380_1_6 SeqId_4925_54 'MMP-13 chr11:102824826_C_T$SeqId_4925_54 1 chr11:102824826_C_T rs478927 cis 11 102824826 T C 0.314 0.1122 0.0145 8.59e-15 'Collagenase 3 ENSG00000137745 'MMP13 intron_variant ENSG00000137745 ENSG00000137745 'MMP13 3 known suggestive_specific_pathway MMP13 chr11 102942995 102955732 -1 4322 protein_coding 11:102954097 1635 380_2_1 SeqId_17140_57 'PDGFD chr11:104028877_A_G$SeqId_17140_57 1 chr11:104028877_A_G rs7115797 cis 11 104028877 A G 0.2933 -0.4567 0.0137 1.13e-242 'Platelet-derived growth factor D ENSG00000170962 'PDGFD intron_variant ENSG00000170962 ENSG00000170962 'PDGFD 3 known unspecific_effect PDGFD chr11 103907189 104164379 -1 80310 protein_coding 11:104158149 6230 380_2_1 SeqId_9341_1 'PDGFD chr11:104028877_A_G$SeqId_9341_1 1 chr11:104028877_A_G rs7115797 cis 11 104028877 A G 0.2932 -0.3763 0.0132 4.05e-178 'Platelet-derived growth factor D ENSG00000170962 'PDGFD intron_variant ENSG00000170962 ENSG00000170962 'PDGFD 3 known unspecific_effect PDGFD chr11 103907189 104164379 -1 80310 protein_coding 11:104158149 6230 381_1_1 SeqId_19197_95 'THIL chr11:107998126_A_G$SeqId_19197_95 1 chr11:107998126_A_G rs112087419 cis 11 107998126 A G 0.1785 0.4476 0.0167 2.02e-157 'Acetyl-CoA acetyltransferase, mitochondrial ENSG00000075239 'ACAT1 intron_variant ENSG00000075239 ENSG00000075239 'ACAT1 3 novel suggestive_specific_pathway ACAT1 chr11 108116695 108147603 1 38 protein_coding 11:108127399 10704 381_1_2 SeqId_8296_117 'KDEL2 chr11:108357137_A_G$SeqId_8296_117 1 chr11:108357137_A_G rs74911261 cis 11 108357137 A G 0.0262 -1.3026 0.038 1.72e-257 'KDEL motif-containing protein 2 ENSG00000178202 'KDELC2 missense_variant ENSG00000178202 ENSG00000178202 'POGLUT3 3 known specific_protein POGLUT3 chr11 108472112 108498384 -1 143888 protein_coding 11:108486410 11974 382_1_2 SeqId_18319_7 'ODPX chr11:111809489_C_T$SeqId_18319_7 1 chr11:111809489_C_T rs10891301 trans 11 111809489 T C 0.37 0.1124 0.0127 1.09e-18 'Pyruvate dehydrogenase protein X component, mitochondrial ENSG00000110435 'PDHX intron_variant 0.996621 rs10891314 ENSG00000150768 'DLAT missense_variant ENSG00000150768 ENSG00000150768 'DLAT 4 novel specific_protein PDHX chr11 34915829 35020591 1 8050 protein_coding 11:111938765 77022936 382_2_1 SeqId_4498_62 'NCAM-120 chr11:112975934_C_T$SeqId_4498_62 1 chr11:112975934_C_T rs11214489 cis 11 112975934 T C 0.1847 -0.3073 0.017 3.08e-73 'Neural cell adhesion molecule 1, 120 kDa isoform ENSG00000149294 'NCAM1 intron_variant ENSG00000149294 ENSG00000149294 'NCAM1 3 known specific_protein -0.3792 0.078989 2.11105719580854e-06 yes NCAM1 Olink CARDIOMETABOLIC(v.3602) NCAM1 chr11 112961247 113278436 1 4684 protein_coding 11:113105212 143965 382_3_2 SeqId_13590_1 'ORN chr11:114301927_C_T$SeqId_13590_1 1 chr11:114301927_C_T rs17116987 cis 11 114301927 T C 0.8483 0.1711 0.017 8.6e-24 'Oligoribonuclease, mitochondrial ENSG00000076043 'REXO2 intron_variant ENSG00000076043 ENSG00000076043 'REXO2 3 known suggestive_specific_pathway REXO2 chr11 114439435 114450279 1 25996 protein_coding 11:114431205 8230 382_4_1 SeqId_3326_58 'Nectin-like protein 2 chr11:115036419_A_T$SeqId_3326_58 1 chr11:115036419_A_T rs11215391 cis 11 115036419 A T 0.7422 -0.1797 0.0145 4.96e-35 'Cell adhesion molecule 1 ENSG00000182985 'CADM1 downstream_gene_variant ENSG00000182985 ENSG00000182985 'CADM1 3 novel specific_protein CADM1 chr11 115169218 115504957 -1 23705 protein_coding 11:115165699 339258 383_1_2 SeqId_13022_20 'P5I11 chr11:116648917_C_G$SeqId_13022_20 1 chr11:116648917_C_G rs964184 trans 11 116648917 C G 0.8666 -0.218 0.0192 8.38e-30 'Tumor protein p53-inducible protein 11 ENSG00000175274 'TP53I11 3_prime_UTR_variant 0.433282 rs35120633 ENSG00000109917 'ZNF259 missense_variant none ENSG00000110245 'APOC3 5 known unspecific_effect TP53I11 chr11 44885903 44951306 -1 9537 protein_coding 11:116778201 71826895 383_1_2 SeqId_2788_55 'MMP-3 chr11:116623213_D_I$SeqId_2788_55 1 chr11:116623213_D_I rs66505542 trans 11 116623213 D I 0.8579 -0.1365 0.0193 1.51e-12 'Stromelysin-1 ENSG00000149968 'MMP3 intron_variant 0.43336 rs11820589 ENSG00000137656 'BUD13 missense_variant ENSG00000109917|ENSG00000110243|ENSG00000110245|ENSG00000118137|ENSG00000186318 ENSG00000110245 'APOC3 5 known unspecific_effect MMP3 chr11 102835801 102843609 -1 4314 protein_coding 11:116752498 13908889 383_1_2 SeqId_6461_54 'Apo C-III chr11:116648917_C_G$SeqId_6461_54 1 chr11:116648917_C_G rs964184 cis 11 116648917 C G 0.8666 -0.2103 0.0196 8.39e-27 'Apolipoprotein C-III ENSG00000110245 'APOC3 3_prime_UTR_variant 0.433282 rs35120633 ENSG00000109917 'ZNF259 missense_variant ENSG00000110245 ENSG00000110245 'APOC3 5 known unspecific_effect APOC3 chr11 116829706 116833072 1 345 protein_coding 11:116778201 51505 383_1_2 SeqId_8760_10 'DCNL5 chr11:116648917_C_G$SeqId_8760_10 1 chr11:116648917_C_G rs964184 trans 11 116648917 C G 0.8666 -0.1665 0.0195 1.6e-17 'DCN1-like protein 5 ENSG00000137692 'DCUN1D5 3_prime_UTR_variant 0.433282 rs35120633 ENSG00000109917 'ZNF259 missense_variant ENSG00000110274|ENSG00000186318 ENSG00000110245 'APOC3 5 known unspecific_effect DCUN1D5 chr11 103050686 103092194 -1 84259 protein_coding 11:116778201 13686007 383_1_4 SeqId_17685_9 'Apo A-IV chr11:116692293_A_C$SeqId_17685_9 1 chr11:116692293_A_C rs12721043 cis 11 116692293 A C 0.0103 -0.7211 0.0678 2.08e-26 'Apolipoprotein A-IV ENSG00000110244 'APOA4 missense_variant ENSG00000110244 ENSG00000110244 'APOA4 6 novel suggestive_specific_pathway APOA4 chr11 116820700 116823304 -1 337 protein_coding 11:116821577 1727 383_1_5 SeqId_15363_32 'Apo A-V chr11:116662407_C_G$SeqId_15363_32 1 chr11:116662407_C_G rs3135506 cis 11 116662407 C G 0.0619 1.487 0.0226 1.04e-942 'Apolipoprotein A-V ENSG00000110243 'APOA5 missense_variant ENSG00000110243 ENSG00000110243 'APOA5 3 known unspecific_effect APOA5 chr11 116789367 116792420 -1 116519 protein_coding 11:116791691 729 383_1_7 SeqId_15640_54 'TAGL chr11:117030581_A_T$SeqId_15640_54 1 chr11:117030581_A_T rs1871757 cis 11 117030581 A T 0.827 -0.1309 0.0165 2.12e-15 'Transgelin ENSG00000149591 'TAGLN intron_variant ENSG00000149591 ENSG00000149591 'TAGLN 3 known unspecific_effect TAGLN chr11 117199370 117207464 1 6876 protein_coding 11:117159865 39505 383_1_8 SeqId_4459_68 'PCSK7 chr11:117076708_C_T$SeqId_4459_68 1 chr11:117076708_C_T rs35186251 cis 11 117076708 T C 0.7694 1.0305 0.0122 4.93e-1552 'Proprotein convertase subtilisin/kexin type 7 ENSG00000160613 'PCSK7 3_prime_UTR_variant 0.106961 rs201598301 ENSG00000160613 'PCSK7 missense_variant ENSG00000160613 ENSG00000160613 'PCSK7 3 known unspecific_effect PCSK7 chr11 117204337 117232525 -1 9159 protein_coding 11:117205992 26533 384_1_2 SeqId_12016_60 'CBL chr11:119152684_C_T$SeqId_12016_60 1 chr11:119152684_C_T rs76683040 cis 11 119152684 T C 0.0739 -0.3947 0.024 8.35e-61 'E3 ubiquitin-protein ligase CBL ENSG00000110395 'CBL intron_variant ENSG00000110395 ENSG00000110395 'CBL 3 known specific_protein -0.17389 0.11282 0.123879658653037 no CBL Olink CELL REGULATION(v.3701) CBL chr11 119206298 119313926 1 867 protein_coding 11:119281974 75676 384_1_3 SeqId_7810_20 'C1QTNF5 chr11:119208576_A_G$SeqId_7810_20 1 chr11:119208576_A_G rs2509656 cis 11 119208576 A G 0.1453 0.2528 0.0181 3.89e-44 'Complement C1q tumor necrosis factor-related protein 5 ENSG00000223953 'C1QTNF5 downstream_gene_variant ENSG00000223953 ENSG00000223953 'C1QTNF5 3 known unspecific_effect C1QTNF5 chr11 119338942 119340940 -1 114902 protein_coding 11:119337866 3074 384_2_1 SeqId_6414_8 'OAF chr11:120101092_A_T$SeqId_6414_8 1 chr11:120101092_A_T rs2845705 cis 11 120101092 A T 0.2059 0.6202 0.0148 9.02e-384 'Out at first protein homolog ENSG00000184232 'OAF downstream_gene_variant 0.996252 rs2508490 ENSG00000184232 'OAF missense_variant ENSG00000184232 ENSG00000184232 'OAF 5 known suggestive_specific_pathway OAF chr11 120211032 120230334 1 220323 protein_coding 11:120230383 19351 385_1_1 SeqId_12558_3 'UBS3B chr11:122526069_C_T$SeqId_12558_3 1 chr11:122526069_C_T rs7116968 cis 11 122526069 T C 0.2489 -0.2099 0.0146 7.91e-47 'Ubiquitin-associated and SH3 domain-containing protein B ENSG00000154127 'UBASH3B upstream_gene_variant ENSG00000154127 ENSG00000154127 'UBASH3B 3 known specific_protein UBASH3B chr11 122655722 122814473 1 84959 protein_coding 11:122655361 361 385_2_2 SeqId_7968_15 'CRTAM chr11:122714782_A_G$SeqId_7968_15 1 chr11:122714782_A_G rs2370794 cis 11 122714782 A G 0.6724 -0.255 0.0138 1.62e-76 'Cytotoxic and regulatory T-cell molecule ENSG00000109943 'CRTAM intron_variant ENSG00000109943 ENSG00000109943 'CRTAM 3 known specific_protein CRTAM chr11 122838500 122872643 1 56253 protein_coding 11:122844074 5574 385_2_3 SeqId_10440_26 'ACAM chr11:123067655_G_T$SeqId_10440_26 1 chr11:123067655_G_T rs2155572 cis 11 123067655 T G 0.5835 0.215 0.0123 4.59e-68 'CXADR-like membrane protein ENSG00000166250 'CLMP upstream_gene_variant ENSG00000166250 ENSG00000166250 'CLMP 3 known specific_protein CLMP chr11 123069872 123195248 -1 79827 protein_coding 11:123196947 1699 386_1_10 SeqId_7841_84 'ESAM chr11:124624150_A_G$SeqId_7841_84 1 chr11:124624150_A_G rs12792040 cis 11 124624150 A G 0.0935 -0.5269 0.0226 1.5e-120 'Endothelial cell-selective adhesion molecule ENSG00000149564 'ESAM missense_variant ENSG00000149564 ENSG00000149564 'ESAM 3 known specific_protein 0.11541 0.11532 0.317431484402768 no ESAM Olink DEVELOPMENT(v.3511) ESAM chr11 124752583 124762290 -1 90952 protein_coding 11:124754254 8036 386_1_11 SeqId_8065_245 'PATE4 chr11:125698654_A_T$SeqId_8065_245 1 chr11:125698654_A_T rs875500 cis 11 125698654 A T 0.7183 -0.2715 0.0146 6.38e-77 'Prostate and testis expressed protein 4 ENSG00000237353 'PATE4 upstream_gene_variant 0.560291 rs11220236 ENSG00000237353 'PATE4 splice_acceptor_variant ENSG00000237353 ENSG00000237353 'PATE4 3 known specific_protein PATE4 chr11 125833316 125840072 1 399968 protein_coding 11:125828759 4557 386_1_12 SeqId_4541_49 'CDON chr11:125889893_D_I$SeqId_4541_49 1 chr11:125889893_D_I rs201453301 cis 11 125889893 D I 0.0881 -0.8595 0.0214 1.04e-352 'Cell adhesion molecule-related/down-regulated by oncogenes ENSG00000064309 'CDON intron_variant 1.0 rs3740909 ENSG00000064309 'CDON missense_variant ENSG00000064309 ENSG00000064309 'CDON 3 known specific_protein 0.45227 0.11058 5.05010025670316e-05 no CDON Olink DEVELOPMENT(v.3511) CDON chr11 125955796 126063335 -1 50937 protein_coding 11:126019999 43336 386_1_15 SeqId_9839_148 'Tirap chr11:126285301_A_G$SeqId_9839_148 1 chr11:126285301_A_G rs7949566 cis 11 126285301 A G 0.4369 -0.2149 0.0127 1.38e-64 'Toll/interleukin-1 receptor domain-containing adapter protein ENSG00000150455 'TIRAP downstream_gene_variant ENSG00000150455 ENSG00000150455 'TIRAP 3 known unspecific_effect TIRAP chr11 126283065 126298845 1 114609 protein_coding 11:126415406 132341 386_1_3 SeqId_5596_75 'CD5 chr11:126234820_C_G$SeqId_5596_75 1 chr11:126234820_C_G rs78689694 trans 11 126234820 C G 0.1311 -0.1696 0.0188 1.98e-19 'T-cell surface glycoprotein CD5 ENSG00000110448 'CD5 intron_variant ENSG00000110080|ENSG00000149554 ENSG00000110080 'ST3GAL4 2 known unspecific_effect CD5 chr11 61102489 61127852 1 921 protein_coding 11:126364925 65262436 386_1_5 SeqId_3206_4 'LYVE1 chr11:126225876_C_G$SeqId_3206_4 1 chr11:126225876_C_G rs112771035 trans 11 126225876 C G 0.9294 -0.505 0.0244 1.56e-95 'Lymphatic vessel endothelial hyaluronic acid receptor 1 ENSG00000133800 'LYVE1 5_prime_UTR_variant 0.166719 rs8177399 ENSG00000150455 'TIRAP missense_variant ENSG00000110080|ENSG00000149554 ENSG00000110080|ENSG00000149554|ENSG00000149571 'CHEK1|KIRREL3|ST3GAL4 1 known unspecific_effect -0.62299 0.11282 5.47772215655659e-08 yes LYVE1 Olink CARDIOMETABOLIC(v.3602) LYVE1 chr11 10556966 10611689 -1 10894 protein_coding 11:126355981 115744292 386_1_9 SeqId_9263_57 'SIAE chr11:124530664_C_T$SeqId_9263_57 1 chr11:124530664_C_T rs78778622 cis 11 124530664 T C 0.9431 0.3243 0.0281 8.33e-31 'Sialate O-acetylesterase ENSG00000110013 'SIAE missense_variant ENSG00000110013 ENSG00000110013 'SIAE 3 novel specific_protein SIAE chr11 124633113 124695707 -1 54414 protein_coding 11:124660768 34939 387_1_1 SeqId_10627_87 'APLP2 chr11:129955055_D_I$SeqId_10627_87 1 chr11:129955055_D_I rs541398240 cis 11 129955055 D I 0.9511 -0.4006 0.0284 4.82e-45 'Amyloid-like protein 2 ENSG00000084234 'APLP2 intron_variant ENSG00000084234 ENSG00000084234 'APLP2 3 known specific_protein APLP2 chr11 130068147 130144811 1 334 protein_coding 11:130085161 17014 388_1_1 SeqId_10907_116 'NTRI chr11:131196396_C_T$SeqId_10907_116 1 chr11:131196396_C_T rs2511504 cis 11 131196396 T C 0.5579 -0.2297 0.012 1.06e-81 'Neurotrimin ENSG00000182667 'NTM intron_variant,non_coding_transcript_variant ENSG00000182667 ENSG00000182667 'NTM 5 known specific_pathway NTM chr11 131370478 132336822 1 50863 protein_coding 11:131326501 43977 388_1_1 SeqId_15622_13 'OBCAM chr11:131196396_C_T$SeqId_15622_13 1 chr11:131196396_C_T rs2511504 trans 11 131196396 T C 0.5579 -0.2183 0.0122 2.89e-71 'Opioid-binding protein/cell adhesion molecule ENSG00000183715 'OPCML intron_variant,non_coding_transcript_variant ENSG00000182667 ENSG00000182667 'NTM 5 known specific_pathway OPCML chr11 132414977 133532501 -1 4978 protein_coding 11:131326501 2206000 388_1_1 SeqId_8428_102 'NTRI chr11:131196396_C_T$SeqId_8428_102 1 chr11:131196396_C_T rs2511504 cis 11 131196396 T C 0.5579 -0.3836 0.0115 3.98e-244 'Neurotrimin ENSG00000182667 'NTM intron_variant,non_coding_transcript_variant ENSG00000182667 ENSG00000182667 'NTM 5 known specific_pathway NTM chr11 131370478 132336822 1 50863 protein_coding 11:131326501 43977 39_1_1 SeqId_13384_110 'FUMH chr1:241683705_A_C$SeqId_13384_110 1 chr1:241683705_A_C rs12071124 cis 1 241683705 A C 0.7236 0.1683 0.0147 2.67e-30 'Fumarate hydratase, mitochondrial ENSG00000091483 'FH upstream_gene_variant ENSG00000091483 ENSG00000091483 'FH 4 known suggestive_specific_pathway FH chr1 241497511 241519799 -1 2271 protein_coding 1:241520405 606 390_1_2 SeqId_16070_7 'WIF-1 chr12:590449_C_T$SeqId_16070_7 1 chr12:590449_C_T rs215224 trans 12 590449 T C 0.5976 -0.0994 0.0131 3.89e-14 'Wnt inhibitory factor 1 ENSG00000156076 'WIF1 intron_variant ENSG00000139044 ENSG00000139044 'B4GALNT3 1 known unspecific_effect WIF1 chr12 65050626 65121305 -1 11197 protein_coding 12:481283 64640022 391_1_1 SeqId_17722_5 'FKBP52 protein chr12:2905888_A_G$SeqId_17722_5 1 chr12:2905888_A_G rs57120900 cis 12 2905888 A G 0.9635 0.2508 0.0353 1.21e-12 'Peptidyl-prolyl cis-trans isomerase FKBP4 ENSG00000004478 'FKBP4 intron_variant ENSG00000004478 ENSG00000004478 'FKBP4 3 novel specific_protein FKBP4 chr12 2794970 2805423 1 2288 protein_coding 12:2796722 1752 392_1_2 SeqId_3050_7 'vWF chr12:6128388_C_T$SeqId_3050_7 1 chr12:6128388_C_T rs1800382 cis 12 6128388 T C 0.0134 -1.2449 0.0596 9.7e-97 'von Willebrand factor ENSG00000110799 'VWF missense_variant ENSG00000110799 ENSG00000110799 'VWF 3 novel suggestive_specific_pathway -0.25494 0.24418 0.29698191271513 no vWF Olink CARDIOVASCULAR III(v.6112) VWF chr12 5948877 6124770 -1 7450 protein_coding 12:6019222 105548 392_2_10 SeqId_10339_48 'NSE chr12:7005225_A_C$SeqId_10339_48 1 chr12:7005225_A_C 12:7005225_C_A cis 12 7005225 A C 0.2592 0.1729 0.0157 2.33e-28 'Gamma-enolase ENSG00000111674 'ENO2 intron_variant ENSG00000111674 ENSG00000111674 'ENO2 3 known unspecific_effect 0.3871 0.06943 4.11244402726609e-08 yes ENO2 Olink METABOLISM(v.3402) ENO2 chr12 6913745 6923698 1 2026 protein_coding 12:6896061 17684 392_2_12 SeqId_9348_1 'C1RL1 chr12:7254686_C_G$SeqId_9348_1 1 chr12:7254686_C_G rs191448232 cis 12 7254686 C G 0.0128 -2.2315 0.0572 6.64e-333 'Complement C1r subcomponent-like protein ENSG00000139178 'C1RL splice_region_variant,intron_variant ENSG00000139178 ENSG00000139178 'C1RL 3 known suggestive_specific_pathway C1RL chr12 7089587 7109238 -1 51279 protein_coding 12:7102090 7148 392_2_13 SeqId_19241_31 'RBP-III chr12:7276251_A_G$SeqId_19241_31 1 chr12:7276251_A_G rs2290239 cis 12 7276251 A G 0.677 0.1897 0.0135 4.22e-45 'Retinol-binding protein 5 ENSG00000139194 'RBP5 downstream_gene_variant 0.288024 rs2290237 ENSG00000139194 'RBP5 missense_variant ENSG00000139194 ENSG00000139194 'RBP5 3 novel unspecific_effect RBP5 chr12 7115736 7128889 -1 83758 protein_coding 12:7123655 5234 392_2_17 SeqId_5028_59 'sCD163 chr12:7769776_A_G$SeqId_5028_59 1 chr12:7769776_A_G rs11054859 cis 12 7769776 A G 0.1062 -0.1476 0.0217 9.84e-12 'Scavenger receptor cysteine-rich type 1 protein M130 ENSG00000177575 'CD163 intergenic_variant ENSG00000177575 ENSG00000177575 'CD163 3 novel specific_protein CD163 chr12 7470811 7503893 -1 9332 protein_coding 12:7617180 113287 392_2_18 SeqId_9094_5 'CLC4C chr12:7900994_C_T$SeqId_9094_5 1 chr12:7900994_C_T rs7302014 cis 12 7900994 T C 0.5883 -0.5841 0.012 5.46e-517 'C-type lectin domain family 4 member C ENSG00000198178 'CLEC4C intron_variant 0.580204 rs73056605 ENSG00000198178 'CLEC4C missense_variant ENSG00000198178 ENSG00000198178 'CLEC4C 3 known specific_protein -0.52314 0.057991 4.3752210515825e-18 yes CLEC4C Olink IMMUNE RESPONSE(v.3202) CLEC4C chr12 7729383 7751605 -1 170482 protein_coding 12:7748398 3207 392_2_2 SeqId_11320_29 'CHFR chr12:7176204_A_G$SeqId_11320_29 1 chr12:7176204_A_G rs10849546 trans 12 7176204 A G 0.1319 -0.3119 0.0196 5.02e-57 'E3 ubiquitin-protein ligase CHFR ENSG00000072609 'CHFR intron_variant 0.998552 rs12146727 ENSG00000182326 'C1S missense_variant ENSG00000182326 ENSG00000182326 'C1S 8 known unspecific_effect CHFR chr12 132822187 132956304 -1 55743 protein_coding 12:7068900 125887404 392_2_2 SeqId_3285_23 'C1r chr12:7170336_A_G$SeqId_3285_23 1 chr12:7170336_A_G rs12146727 cis 12 7170336 A G 0.1318 -0.4303 0.0197 6.3e-106 'Complement C1r subcomponent ENSG00000159403 'C1R missense_variant ENSG00000159403 ENSG00000182326 'C1S 8 known unspecific_effect C1R chr12 7080214 7092540 -1 715 protein_coding 12:7063032 29508 392_2_2 SeqId_8840_61 'C1s chr12:7170336_A_G$SeqId_8840_61 1 chr12:7170336_A_G rs12146727 cis 12 7170336 A G 0.1317 -1.1065 0.0172 2.65e-901 'Complement C1s subcomponent ENSG00000182326 'C1S missense_variant ENSG00000182326 ENSG00000182326 'C1S 8 known unspecific_effect C1S chr12 6988259 7071032 1 716 protein_coding 12:7063032 74773 392_2_3 SeqId_5879_51 'Dynactin subunit 2 chr12:7242204_C_T$SeqId_5879_51 1 chr12:7242204_C_T rs1126605 trans 12 7242204 T C 0.0876 0.3319 0.0233 7.21e-46 'Dynactin subunit 2 ENSG00000175203 'DCTN2 downstream_gene_variant 0.761951 rs36136293 ENSG00000159403 'C1R missense_variant ENSG00000139178|ENSG00000111665|ENSG00000111669|ENSG00000111679|ENSG00000126749 ENSG00000182326 'C1S 4 known unspecific_effect -0.15873 0.11049 0.151481640586803 no DCTN2 Olink CELL REGULATION(v.3701) DCTN2 chr12 57529633 57547224 -1 10540 protein_coding 12:7089608 50457616 392_2_5 SeqId_14204_55 'FOXJ2 chr12:8166718_C_G$SeqId_14204_55 1 chr12:8166718_C_G rs12831827 cis 12 8166718 C G 0.5757 -0.1678 0.0136 4.76e-35 'Forkhead box protein J2 ENSG00000065970 'FOXJ2 upstream_gene_variant ENSG00000065970 ENSG00000065970 'FOXJ2 3 known unspecific_effect FOXJ2 chr12 8032716 8055517 1 55810 protein_coding 12:8014122 18594 392_2_6 SeqId_14114_18 'PIANP chr12:6809896_C_G$SeqId_14114_18 1 chr12:6809896_C_G rs11064321 cis 12 6809896 C G 0.4035 0.1437 0.0147 1.34e-22 'PILR alpha-associated neural protein ENSG00000139200 'PIANP upstream_gene_variant ENSG00000139200 ENSG00000139200 'PIANP 3 known unspecific_effect PIANP chr12 6693791 6700815 -1 196500 protein_coding 12:6700730 85 392_2_6 SeqId_9599_6 'PIANP chr12:6809896_C_G$SeqId_9599_6 1 chr12:6809896_C_G rs11064321 cis 12 6809896 C G 0.4035 0.1403 0.0143 1.11e-22 'PILR alpha-associated neural protein ENSG00000139200 'PIANP upstream_gene_variant ENSG00000139200 ENSG00000139200 'PIANP 3 known unspecific_effect PIANP chr12 6693791 6700815 -1 196500 protein_coding 12:6700730 85 392_2_8 SeqId_6364_7 'TPSNR chr12:6564210_A_G$SeqId_6364_7 1 chr12:6564210_A_G rs2532497 cis 12 6564210 A G 0.2833 1.2999 0.0085 1.61e-5081 'Tapasin-related protein ENSG00000139192 'TAPBPL intron_variant 0.994235 rs2041385 ENSG00000139192 'TAPBPL missense_variant ENSG00000139192 ENSG00000139192 'TAPBPL 3 known unspecific_effect TAPBPL chr12 6451690 6466517 1 55080 protein_coding 12:6455044 3354 392_2_9 SeqId_9950_229 'LAG-3 chr12:6885076_A_G$SeqId_9950_229 1 chr12:6885076_A_G rs3782735 cis 12 6885076 A G 0.5981 0.1697 0.0145 8.96e-32 'Lymphocyte activation gene 3 protein ENSG00000089692 'LAG3 intron_variant ENSG00000089692 ENSG00000089692 'LAG3 3 known specific_protein 0.19014 0.064396 0.00330293479396034 yes LAG3 Olink IMMUNE RESPONSE(v.3202) LAG3 chr12 6772512 6778455 1 3902 protein_coding 12:6775910 3398 392_3_1 SeqId_15482_12 'A2ML1 chr12:9009820_A_G$SeqId_15482_12 1 chr12:9009820_A_G rs1558526 cis 12 9009820 A G 0.2595 -0.3039 0.0151 9.5e-90 'Alpha-2-macroglobulin-like protein 1 ENSG00000166535 'A2ML1 missense_variant ENSG00000166535 ENSG00000166535 'A2ML1 3 novel specific_protein A2ML1 chr12 8822621 8887001 1 144568 protein_coding 12:8857224 34603 392_4_2 SeqId_6580_29 'Pregnancy zone protein chr12:9362168_C_T$SeqId_6580_29 1 chr12:9362168_C_T rs1035849 cis 12 9362168 T C 0.3255 -0.3679 0.009 2.75e-365 'Pregnancy zone protein ENSG00000126838 'PZP upstream_gene_variant 0.35579 rs12230214 ENSG00000126838 'PZP missense_variant ENSG00000126838 ENSG00000126838 'PZP 3 known unspecific_effect PZP chr12 9148840 9208395 -1 5858 protein_coding 12:9209572 1177 392_4_3 SeqId_3708_62 'a2-Macroglobulin chr12:9263647_C_T$SeqId_3708_62 1 chr12:9263647_C_T rs226384 cis 12 9263647 T C 0.347 -0.1357 0.0126 7.14e-27 'Alpha-2-macroglobulin ENSG00000175899 'A2M intron_variant 0.958534 rs669 ENSG00000175899 'A2M missense_variant ENSG00000175899 ENSG00000175899 'A2M 6 novel unspecific_effect A2M chr12 9067664 9116229 -1 2 protein_coding 12:9111051 5178 392_4_4 SeqId_10809_14 'KLRB1 chr12:9741500_A_G$SeqId_10809_14 1 chr12:9741500_A_G rs4763630 cis 12 9741500 A G 0.5866 0.3129 0.0131 3.34e-125 'Killer cell lectin-like receptor subfamily B member 1 ENSG00000111796 'KLRB1 regulatory_region_variant 0.974702 rs1135816 ENSG00000111796 'KLRB1 missense_variant ENSG00000111796 ENSG00000111796 'KLRB1 3 known unspecific_effect KLRB1 chr12 9594551 9607916 -1 3820 protein_coding 12:9588904 19012 392_4_5 SeqId_4332_6 'CLC1B chr12:10109841_A_C$SeqId_4332_6 1 chr12:10109841_A_C rs4763395 cis 12 10109841 A C 0.3866 0.1872 0.0129 1.47e-47 'C-type lectin domain family 1 member B ENSG00000165682 'CLEC1B intron_variant 0.122838 rs2273987 ENSG00000165682 'CLEC1B missense_variant ENSG00000165682 ENSG00000165682 'CLEC1B 3 known suggestive_specific_pathway 0.079867 0.065237 0.221462398940567 no CLEC1B Olink NEUROLOGY(v.8011) CLEC1B chr12 9985642 10013424 -1 51266 protein_coding 12:9957242 56182 392_4_6 SeqId_11187_11 'CL12A chr12:10137645_G_T$SeqId_11187_11 1 chr12:10137645_G_T rs588272 cis 12 10137645 T G 0.3594 1.2184 0.0075 8.71e-5734 'C-type lectin domain family 12 member A ENSG00000172322 'CLEC12A 3_prime_UTR_variant 0.998546 rs479499 ENSG00000172322 'CLEC12A missense_variant ENSG00000172322 ENSG00000172322 'CLEC12A 3 known suggestive_specific_pathway CLEC12A chr12 9951316 9995694 1 160364 protein_coding 12:9985046 33730 393_1_1 SeqId_9557_5 'MANS1 chr12:12496935_A_G$SeqId_9557_5 1 chr12:12496935_A_G rs56829405 cis 12 12496935 A G 0.1192 0.5217 0.0198 2.53e-152 'MANSC domain-containing protein 1 ENSG00000111261 'MANSC1 intron_variant 0.997861 rs3741798 ENSG00000111261 'MANSC1 missense_variant ENSG00000111261 ENSG00000111261 'MANSC1 3 known specific_protein MANSC1 chr12 12326056 12350242 -1 54682 protein_coding 12:12344001 6241 393_2_1 SeqId_3719_2 'p27Kip1 chr12:12868452_C_T$SeqId_3719_2 1 chr12:12868452_C_T rs3759217 cis 12 12868452 T C 0.1151 0.2051 0.0207 3.43e-23 'Cyclin-dependent kinase inhibitor 1B ENSG00000111276 'CDKN1B upstream_gene_variant ENSG00000111276 ENSG00000111276 'CDKN1B 3 novel specific_protein CDKN1B chr12 12685498 12722369 1 1027 protein_coding 12:12715518 30020 393_2_3 SeqId_18225_13 'HEBP1 chr12:13128263_C_G$SeqId_18225_13 1 chr12:13128263_C_G rs1941 cis 12 13128263 C G 0.9605 1.6083 0.0316 5.08e-565 'Heme-binding protein 1 ENSG00000013583 'HEBP1 missense_variant ENSG00000013583 ENSG00000013583 'HEBP1 3 novel specific_protein HEBP1 chr12 12974870 13000265 -1 50865 protein_coding 12:12975329 24936 393_2_4 SeqId_9981_18 'K1467 chr12:13215613_A_G$SeqId_9981_18 1 chr12:13215613_A_G rs117688503 cis 12 13215613 A G 0.0215 0.4992 0.0443 1.94e-29 'Protein FAM234B ENSG00000084444 'KIAA1467 intron_variant 0.855209 rs117039796 ENSG00000084444 'KIAA1467 missense_variant ENSG00000084444 ENSG00000084444 'FAM234B 3 known specific_protein FAM234B chr12 13044381 13142521 1 57613 protein_coding 12:13062679 18298 393_2_5 SeqId_6520_87 'MGP chr12:15047396_C_T$SeqId_6520_87 1 chr12:15047396_C_T rs2430687 cis 12 15047396 T C 0.6041 0.406 0.0132 4.04e-208 'Matrix Gla protein ENSG00000111341 'MGP intron_variant 0.994617 rs4236 ENSG00000111341 'MGP missense_variant ENSG00000111341 ENSG00000111339|ENSG00000111341 'ART4|MGP 3 known suggestive_specific_pathway MGP chr12 14880864 14885857 -1 4256 protein_coding 12:14894462 8605 393_2_5 SeqId_6576_1 'ART4 chr12:14990587_A_G$SeqId_6576_1 1 chr12:14990587_A_G rs10772808 cis 12 14990587 A G 0.3984 0.8973 0.0103 9.32e-1651 'Ecto-ADP-ribosyltransferase 4 ENSG00000111339 'ART4 intron_variant 0.998838 rs11276 ENSG00000111339 'ART4 missense_variant ENSG00000111339 ENSG00000111339|ENSG00000111341 'ART4|MGP 3 known suggestive_specific_pathway ART4 chr12 14825569 14843526 -1 420 protein_coding 12:14837653 5873 395_1_1 SeqId_5254_69 'PDE3A chr12:20834162_A_G$SeqId_5254_69 1 chr12:20834162_A_G rs954865 cis 12 20834162 A G 0.3356 0.1453 0.0136 1.23e-26 'cGMP-inhibited 3',5'-cyclic phosphodiesterase A ENSG00000172572 'PDE3A 3_prime_UTR_variant ENSG00000172572 ENSG00000172572 'PDE3A 3 novel specific_protein PDE3A chr12 20368537 20688583 1 5139 protein_coding 12:20681228 312691 395_2_1 SeqId_11431_235 'RECQ1 chr12:21696251_C_T$SeqId_11431_235 1 chr12:21696251_C_T rs74626198 cis 12 21696251 T C 0.9712 0.259 0.0374 4.17e-12 'ATP-dependent DNA helicase Q1 ENSG00000004700 'RECQL intron_variant ENSG00000004700 ENSG00000004700 'RECQL 3 novel suggestive_specific_pathway RECQL chr12 21468910 21501669 -1 5965 protein_coding 12:21543317 41648 397_1_2 SeqId_9578_263 'MANS4 chr12:27919491_G_T$SeqId_9578_263 1 chr12:27919491_G_T rs9668702 cis 12 27919491 T G 0.7725 -0.7308 0.0143 1.17e-569 'MANSC domain-containing protein 4 ENSG00000205693 'MANSC4 intron_variant 0.637416 rs11049126 ENSG00000205693 'MANSC4 missense_variant ENSG00000205693 ENSG00000205693 'MANSC4 3 known suggestive_specific_pathway MANSC4 chr12 27762427 27780236 -1 100287284 protein_coding 12:27766558 13678 397_1_3 SeqId_2962_50 'PTHrP chr12:28359985_A_G$SeqId_2962_50 1 chr12:28359985_A_G rs12049916 cis 12 28359985 A G 0.7641 -0.1802 0.0154 1.07e-31 'Parathyroid hormone-related protein ENSG00000087494 'PTHLH intron_variant ENSG00000087494 ENSG00000087494 'PTHLH 3 known specific_protein PTHLH chr12 27958084 27972733 -1 5744 protein_coding 12:28207052 234319 398_2_1 SeqId_14067_6 'PKP2 chr12:32974611_C_T$SeqId_14067_6 1 chr12:32974611_C_T rs9919823 cis 12 32974611 T C 0.9714 -0.3166 0.0384 1.54e-16 'Plakophilin-2 ENSG00000057294 'PKP2 intron_variant ENSG00000057294 ENSG00000057294 'PKP2 3 novel specific_protein PKP2 chr12 32790755 32896777 -1 5318 protein_coding 12:32821677 75100 399_1_1 SeqId_2974_61 'contactin-1 chr12:41047721_A_G$SeqId_2974_61 1 chr12:41047721_A_G rs12811939 cis 12 41047721 A G 0.6151 -0.2166 0.0128 7.26e-64 'Contactin-1 ENSG00000018236 'CNTN1 intergenic_variant ENSG00000018236 ENSG00000018236 'CNTN1 3 known specific_protein -0.13605 0.061914 0.0284642667037422 yes CNTN1 Olink CARDIOVASCULAR III(v.6112) CNTN1 chr12 40692439 41072415 1 1272 protein_coding 12:40653919 38520 399_2_1 SeqId_8229_1 'GXLT1 chr12:42527041_C_T$SeqId_8229_1 1 chr12:42527041_C_T rs139695917 cis 12 42527041 T C 0.9868 -1.6732 0.0605 1.61e-168 'Glucoside xylosyltransferase 1 ENSG00000151233 'GXYLT1 intron_variant ENSG00000151233 ENSG00000151233 'GXYLT1 3 known specific_protein GXYLT1 chr12 42081845 42144874 -1 283464 protein_coding 12:42133239 11635 4_1_1 SeqId_7140_1 'ELA2A chr1:15798603_G_T$SeqId_7140_1 1 chr1:15798603_G_T rs188524036 cis 1 15798603 T G 0.9894 0.5175 0.0678 2.37e-14 'Chymotrypsin-like elastase family member 2A ENSG00000142615 'CELA2A upstream_gene_variant ENSG00000142615 ENSG00000142615 'CELA2A 3 novel specific_protein CELA2A chr1 15456728 15472091 1 63036 protein_coding 1:15472108 15380 4_1_2 SeqId_4834_61 'Epithelial cell kinase chr1:16513926_A_G$SeqId_4834_61 1 chr1:16513926_A_G rs924204 cis 1 16513926 A G 0.4081 0.1269 0.013 2.27e-22 'Ephrin type-A receptor 2 ENSG00000142627 'EPHA2 regulatory_region_variant ENSG00000142627 ENSG00000142627 'EPHA2 3 known specific_protein EPHA2 chr1 16124337 16156069 -1 1969 protein_coding 1:16187431 31362 4_2_1 SeqId_10569_28 'MFAP2 chr1:17315425_A_G$SeqId_10569_28 1 chr1:17315425_A_G rs4920605 none 1 17315425 A G 0.5629 0.4465 0.0129 5.12e-263 'Microfibrillar-associated protein 2 intron_variant ENSG00000159363 ENSG00000117122 'MFAP2 3 known suggestive_specific_pathway MFAP2 chr1 16974502 16980632 -1 4237 protein_coding 1:16988930 8298 4_2_1 SeqId_9294_45 'MFAP2 chr1:17315425_A_G$SeqId_9294_45 1 chr1:17315425_A_G rs4920605 cis 1 17315425 A G 0.5628 0.3776 0.0132 1.87e-180 'Microfibrillar-associated protein 2 ENSG00000117122 'MFAP2 intron_variant ENSG00000117122 ENSG00000117122 'MFAP2 3 known suggestive_specific_pathway MFAP2 chr1 16974502 16980632 -1 4237 protein_coding 1:16988930 8298 400_1_1 SeqId_18162_167 'IRAK4 chr12:44120092_C_T$SeqId_18162_167 1 chr12:44120092_C_T rs60813848 cis 12 44120092 T C 0.0729 0.2054 0.0244 4.0e-17 'Interleukin-1 receptor-associated kinase 4 ENSG00000198001 'IRAK4 downstream_gene_variant 0.771832 rs4251545 ENSG00000198001 'IRAK4 missense_variant ENSG00000198001 ENSG00000198001 'IRAK4 3 novel specific_protein IRAK4 chr12 43758944 43789543 1 51135 protein_coding 12:43726289 32655 401_1_1 SeqId_14134_49 'AMGO2 chr12:47478914_A_G$SeqId_14134_49 1 chr12:47478914_A_G rs7964534 cis 12 47478914 A G 0.293 0.1043 0.0148 1.9e-12 'Amphoterin-induced protein 2 ENSG00000139211 'AMIGO2 intron_variant ENSG00000139211 ENSG00000139211 'AMIGO2 3 novel specific_protein AMIGO2 chr12 47075707 47079959 -1 347902 protein_coding 12:47085131 5172 401_2_1 SeqId_5656_53 'PP11 chr12:48132176_C_T$SeqId_5656_53 1 chr12:48132176_C_T rs11168216 cis 12 48132176 T C 0.6984 -0.1457 0.0147 4.84e-23 'Poly(U)-specific endoribonuclease ENSG00000111405 'ENDOU intron_variant ENSG00000111405 ENSG00000111405 'ENDOU 3 known specific_protein ENDOU chr12 47709734 47725567 -1 8909 protein_coding 12:47738393 12826 401_2_2 SeqId_18875_125 'Chondrocalcin chr12:48416052_G_T$SeqId_18875_125 1 chr12:48416052_G_T rs719008 cis 12 48416052 T G 0.3818 -0.8633 0.011 3.25e-1340 'Chondrocalcin ENSG00000139219 'COL2A1 intron_variant 0.298352 rs3803183 ENSG00000139219 'COL2A1 missense_variant ENSG00000139219 ENSG00000139219 'COL2A1 3 known specific_protein COL2A1 chr12 47972967 48004554 -1 1280 protein_coding 12:48022269 17715 401_2_3 SeqId_17384_110 'K6PF chr12:48512285_A_C$SeqId_17384_110 1 chr12:48512285_A_C rs4760682 cis 12 48512285 A C 0.8066 0.159 0.0157 3.86e-24 'ATP-dependent 6-phosphofructokinase, muscle type ENSG00000152556 'PFKM intron_variant ENSG00000152556 ENSG00000152556 'PFKM 3 known suggestive_specific_pathway PFKM chr12 48105139 48146404 1 5213 protein_coding 12:48118502 13363 401_3_2 SeqId_13697_51 'GPDA chr12:50527585_A_G$SeqId_13697_51 1 chr12:50527585_A_G rs78089413 cis 12 50527585 A G 0.0132 0.4664 0.0639 3.0e-13 'Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic ENSG00000167588 'GPD1 intron_variant 0.21732 rs34783513 ENSG00000167588 'GPD1 missense_variant ENSG00000167588 ENSG00000167588 'GPD1 3 novel specific_protein GPD1 chr12 50103982 50111313 1 2819 protein_coding 12:50133802 29820 401_3_3 SeqId_11543_84 'LIMA1 chr12:50628466_C_T$SeqId_11543_84 1 chr12:50628466_C_T rs10783342 cis 12 50628466 T C 0.4216 -0.1777 0.0133 1.32e-40 'LIM domain and actin-binding protein 1 ENSG00000050405 'LIMA1 intron_variant ENSG00000050405 ENSG00000050405 'LIMA1 3 novel specific_protein LIMA1 chr12 50175788 50283520 -1 51474 protein_coding 12:50234683 48837 401_4_2 SeqId_16318_12 'ALK-1 chr12:52312288_A_T$SeqId_16318_12 1 chr12:52312288_A_T rs11169954 cis 12 52312288 A T 0.0848 0.3032 0.0232 5.76e-39 'Serine/threonine-protein kinase receptor R3 ENSG00000139567 'ACVRL1 intron_variant ENSG00000139567 ENSG00000139567 'ACVRL1 3 novel specific_protein 0.58146 0.096757 3.68383355979065e-09 yes SKR3 Olink NEUROLOGY(v.8011) ACVRL1 chr12 51906908 51923361 1 94 protein_coding 12:51918504 11596 401_4_3 SeqId_11177_16 'K2C5 chr12:52912906_G_T$SeqId_11177_16 1 chr12:52912906_G_T rs641621 cis 12 52912906 T G 0.2771 -0.1639 0.0147 8.28e-29 'Keratin, type II cytoskeletal 5 ENSG00000186081 'KRT5 synonymous_variant 0.999412 rs641615 ENSG00000186081 'KRT5 missense_variant ENSG00000186081 ENSG00000186081 'KRT5 3 novel specific_protein KRT5 chr12 52514575 52520530 -1 3852 protein_coding 12:52519122 1408 402_1_2 SeqId_10056_5 'FOXM1 chr12:54687489_C_T$SeqId_10056_5 1 chr12:54687489_C_T rs7304860 trans 12 54687489 T C 0.3618 -0.0904 0.0131 5.56e-12 'Forkhead box protein M1 ENSG00000111206 'FOXM1 intron_variant ENSG00000123405|ENSG00000094916|ENSG00000111481|ENSG00000161642 ENSG00000094916|ENSG00000111481|ENSG00000123338|ENSG00000123405|ENSG00000135486|ENSG00000139572|ENSG00000161642 'CBX5|COPZ1|GPR84|HNRNPA1|NCKAP1L|NFE2|ZNF385A 1 known unspecific_effect FOXM1 chr12 2857680 2877174 -1 2305 protein_coding 12:54293705 51416531 403_1_1 SeqId_6425_87 'MMP19 chr12:56241955_A_G$SeqId_6425_87 1 chr12:56241955_A_G rs7296597 cis 12 56241955 A G 0.0582 -0.2829 0.029 1.48e-22 'Matrix metalloproteinase-19 ENSG00000123342 'MMP19 TF_binding_site_variant ENSG00000123342 ENSG00000123342 'MMP19 3 novel specific_protein MMP19 chr12 55835433 55842966 -1 4327 protein_coding 12:55848171 5205 403_1_2 SeqId_6472_40 'GP100 chr12:56360876_A_G$SeqId_6472_40 1 chr12:56360876_A_G rs2069398 cis 12 56360876 A G 0.0796 0.2641 0.0246 5.46e-27 'Melanocyte protein PMEL ENSG00000185664 'PMEL synonymous_variant ENSG00000185664 ENSG00000185664 'PMEL 3 known unspecific_effect PMEL chr12 55954105 55973317 -1 6490 protein_coding 12:55967092 6225 403_1_3 SeqId_2617_56 'ERBB3 chr12:56556817_C_T$SeqId_2617_56 1 chr12:56556817_C_T rs76400083 cis 12 56556817 T C 0.9886 -0.7262 0.0615 3.7e-32 'Receptor tyrosine-protein kinase erbB-3 ENSG00000065361 'ERBB3 downstream_gene_variant ENSG00000065361 ENSG00000065361 'ERBB3 3 novel specific_protein -1.5196 0.32321 3.37287308658869e-06 yes ERBB3 Olink ONCOLOGY II(v.7002) ERBB3 chr12 56076799 56103505 1 2065 protein_coding 12:56163033 86234 403_1_4 SeqId_12370_30 'Apo F chr12:56689725_C_G$SeqId_12370_30 1 chr12:56689725_C_G rs2643623 cis 12 56689725 C G 0.9324 0.3222 0.0266 9.3e-34 'Apolipoprotein F ENSG00000175336 'APOF intron_variant ENSG00000175336 ENSG00000175336 'APOF 3 known specific_protein APOF chr12 56360568 56362857 -1 319 protein_coding 12:56295941 66916 403_1_6 SeqId_10372_18 'STAT6 chr12:57492996_A_G$SeqId_10372_18 1 chr12:57492996_A_G rs841718 cis 12 57492996 A G 0.6019 0.0925 0.0129 7.94e-13 'Signal transducer and activator of transcription 6 ENSG00000166888 'STAT6 intron_variant ENSG00000166888 ENSG00000166888 'STAT6 3 novel suggestive_specific_pathway STAT6 chr12 57095408 57132139 -1 6778 protein_coding 12:57099213 32926 403_2_1 SeqId_15686_49 'INHBC chr12:57844049_C_T$SeqId_15686_49 1 chr12:57844049_C_T rs3741414 cis 12 57844049 T C 0.2428 -1.3065 0.0093 1.58e-4288 'Inhibin beta C chain ENSG00000175189 'INHBC 3_prime_UTR_variant 0.996952 rs2229357 ENSG00000175189 'INHBC missense_variant ENSG00000175189 ENSG00000175189 'INHBC 6 known specific_pathway -0.42674 0.073384 1.10103214872977e-08 yes INHBC Olink DEVELOPMENT(v.3511) INHBC chr12 57434784 57452062 1 3626 protein_coding 12:57450266 15482 403_2_1 SeqId_18814_21 'Activin AC chr12:57844049_C_T$SeqId_18814_21 1 chr12:57844049_C_T rs3741414 cis 12 57844049 T C 0.2426 -0.1089 0.0152 8.45e-13 'Inhibin beta A chain:Inhibin beta C chain heterodimer ENSG00000122641|ENSG00000175189 'INHBA|INHBC 3_prime_UTR_variant 0.996952 rs2229357 ENSG00000175189 'INHBC missense_variant ENSG00000122641|ENSG00000175189 ENSG00000175189 'INHBC 6 known specific_pathway INHBC chr12 57434784 57452062 1 3626 protein_coding 12:57450266 15482 403_2_2 SeqId_13519_112 'ARHGP chr12:58003922_A_G$SeqId_13519_112 1 chr12:58003922_A_G rs10437954 cis 12 58003922 A G 0.9068 -0.3032 0.0232 4.11e-39 'Rho guanine nucleotide exchange factor 25 ENSG00000240771 'ARHGEF25 upstream_gene_variant ENSG00000240771 ENSG00000240771 'ARHGEF25 3 novel suggestive_specific_pathway ARHGEF25 chr12 57610180 57617245 1 115557 protein_coding 12:57610139 41 403_2_3 SeqId_14291_53 'AGAP2 chr12:58135420_C_T$SeqId_14291_53 1 chr12:58135420_C_T rs12371356 cis 12 58135420 T C 0.5203 0.1125 0.0127 9.41e-19 'Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 ENSG00000135439 'AGAP2 upstream_gene_variant ENSG00000135439 ENSG00000135439 'AGAP2 3 novel unspecific_effect AGAP2 chr12 57723761 57742157 -1 116986 protein_coding 12:57741637 520 403_2_4 SeqId_3322_52 'LRIG3 chr12:59272973_C_T$SeqId_3322_52 1 chr12:59272973_C_T rs11172791 cis 12 59272973 T C 0.9549 0.422 0.0309 1.57e-42 'Leucine-rich repeats and immunoglobulin-like domains protein 3 ENSG00000139263 'LRIG3 intron_variant ENSG00000139263 ENSG00000139263 'LRIG3 3 known specific_protein LRIG3 chr12 58872149 58920504 -1 121227 protein_coding 12:58879191 41313 404_1_1 SeqId_19161_1 'UBP15 chr12:62818841_C_T$SeqId_19161_1 1 chr12:62818841_C_T rs73139022 cis 12 62818841 T C 0.9008 -0.3014 0.022 7.94e-43 'Ubiquitin carboxyl-terminal hydrolase 15 ENSG00000135655 'USP15 intergenic_variant ENSG00000135655 ENSG00000135655 'USP15 3 novel specific_protein USP15 chr12 62260338 62417431 1 9958 protein_coding 12:62425061 164723 405_1_1 SeqId_16070_7 'WIF-1 chr12:65338145_A_G$SeqId_16070_7 1 chr12:65338145_A_G rs462010 cis 12 65338145 A G 0.45 -0.1001 0.013 1.39e-14 'Wnt inhibitory factor 1 ENSG00000156076 'WIF1 intron_variant,non_coding_transcript_variant ENSG00000156076 ENSG00000156076 'WIF1 3 novel specific_protein -0.17478 0.065464 0.00784332118881962 yes WIF-1 Olink ONCOLOGY II(v.7002) WIF1 chr12 65050626 65121305 -1 11197 protein_coding 12:64944365 176940 406_1_1 SeqId_9416_77 'CBPM chr12:69425957_C_T$SeqId_9416_77 1 chr12:69425957_C_T rs7976135 cis 12 69425957 T C 0.1889 -0.1522 0.0167 7.67e-20 'Carboxypeptidase M ENSG00000135678 'CPM intergenic_variant ENSG00000135678 ENSG00000135678 'CPM 3 known specific_protein CPM chr12 68842197 68971570 -1 1368 protein_coding 12:69032177 60607 406_1_2 SeqId_17474_106 'YETS4 chr12:69787291_D_I$SeqId_17474_106 1 chr12:69787291_D_I rs11443013 cis 12 69787291 D I 0.5434 0.1198 0.0131 6.41e-20 'YEATS domain-containing protein 4 ENSG00000127337 'YEATS4 downstream_gene_variant ENSG00000127337 ENSG00000090382|ENSG00000127337 'LYZ|YEATS4 3 known suggestive_specific_pathway YEATS4 chr12 69359710 69390870 1 8089 protein_coding 12:69393512 33802 406_1_2 SeqId_4920_10 'Lysozyme chr12:69732105_C_T$SeqId_4920_10 1 chr12:69732105_C_T rs4761234 cis 12 69732105 T C 0.5286 0.6087 0.0122 4.44e-543 'Lysozyme C ENSG00000090382 'LYZ intergenic_variant ENSG00000090382 ENSG00000090382|ENSG00000127337 'LYZ|YEATS4 3 known suggestive_specific_pathway LYZ chr12 69348381 69354234 1 4069 protein_coding 12:69338325 10056 408_1_1 SeqId_9565_6 'PAWR chr12:79368410_G_T$SeqId_9565_6 1 chr12:79368410_G_T rs73349601 trans 12 79368410 T G 0.2968 -0.0956 0.0137 3.48e-12 'PRKC apoptosis WT1 regulator protein ENSG00000177425 'PAWR intron_variant ENSG00000177425 ENSG00000177425 'PAWR 3 novel specific_protein PAWR chr12 79574979 79690964 -1 5074 protein_coding 12:78974630 716334 409_1_1 SeqId_7208_60 'MGT4C chr12:86373221_C_G$SeqId_7208_60 1 chr12:86373221_C_G rs17855890 cis 12 86373221 C G 0.1015 0.2078 0.0221 5.49e-21 'Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C ENSG00000182050 'MGAT4C missense_variant ENSG00000182050 ENSG00000182050 'MGAT4C 3 novel specific_protein MGAT4C chr12 85955666 86838904 -1 25834 protein_coding 12:85979443 859461 410_1_5 SeqId_13114_50 'Lumican chr12:91539784_C_T$SeqId_13114_50 1 chr12:91539784_C_T rs1803343 cis 12 91539784 T C 0.9785 0.6119 0.0491 1.3e-35 'Lumican ENSG00000139329 'LUM 3_prime_UTR_variant 0.270856 rs147975710 ENSG00000139329 'LUM missense_variant ENSG00000139329 ENSG00000139329 'LUM 3 novel specific_protein LUM chr12 91102629 91111494 -1 4060 protein_coding 12:91146007 34513 411_1_1 SeqId_15322_35 'CRADD chr12:94243853_C_T$SeqId_15322_35 1 chr12:94243853_C_T rs56944668 cis 12 94243853 T C 0.1595 -0.1563 0.0178 1.88e-18 'Death domain-containing protein CRADD ENSG00000169372 'CRADD synonymous_variant ENSG00000169372 ENSG00000169372 'CRADD 3 novel specific_protein CRADD chr12 93677375 93894840 1 8738 protein_coding 12:93850077 172702 411_2_1 SeqId_4564_2 'PLXC1 chr12:94613898_A_G$SeqId_4564_2 1 chr12:94613898_A_G rs115651556 cis 12 94613898 A G 0.0142 -1.7031 0.0537 1.92e-220 'Plexin-C1 ENSG00000136040 'PLXNC1 missense_variant ENSG00000136040 ENSG00000136040 'PLXNC1 3 known specific_protein PLXNC1 chr12 94148577 94307675 1 10154 protein_coding 12:94220122 71545 412_1_1 SeqId_3327_27 'NET4 chr12:96131895_A_G$SeqId_3327_27 1 chr12:96131895_A_G rs17288108 cis 12 96131895 A G 0.827 0.2644 0.017 2.78e-54 'Netrin-4 ENSG00000074527 'NTN4 missense_variant ENSG00000074527 ENSG00000074527 'NTN4 3 known specific_protein NTN4 chr12 95657807 95791189 -1 59277 protein_coding 12:95738117 53072 414_1_1 SeqId_19639_53 'IAPP chr12:102093459_A_G$SeqId_19639_53 1 chr12:102093459_A_G rs2559850 trans 12 102093459 A G 0.593 0.1917 0.0129 1.19e-49 'Islet amyloid polypeptide ENSG00000121351 'IAPP intron_variant ENSG00000111666|ENSG00000017427|ENSG00000183395 ENSG00000017427|ENSG00000111666|ENSG00000183395 'CHPT1|IGF1|PMCH 1 known unspecific_effect IAPP chr12 21354959 21379980 1 3375 protein_coding 12:101699681 80344722 414_1_4 SeqId_8229_1 'GXLT1 chr12:102218899_C_T$SeqId_8229_1 1 chr12:102218899_C_T rs10745925 trans 12 102218899 T C 0.7097 0.2891 0.0144 4.42e-89 'Glucoside xylosyltransferase 1 ENSG00000151233 'GXYLT1 intron_variant ENSG00000111670 ENSG00000111670 'GNPTAB 4 known unspecific_effect GXYLT1 chr12 42081845 42144874 -1 283464 protein_coding 12:101825121 59680247 414_1_5 SeqId_7648_9 'MYPC1 chr12:102048447_A_G$SeqId_7648_9 1 chr12:102048447_A_G rs80087033 cis 12 102048447 A G 0.1517 -0.1307 0.018 3.98e-13 'Myosin-binding protein C, slow-type ENSG00000196091 'MYBPC1 intron_variant 0.998257 rs3817552 ENSG00000196091 'MYBPC1 missense_variant ENSG00000196091 ENSG00000196091 'MYBPC1 3 novel specific_protein MYBPC1 chr12 101568353 101686028 1 4604 protein_coding 12:101654669 86316 415_1_1 SeqId_6393_63 'Endoplasmin chr12:104341398_A_T$SeqId_6393_63 1 chr12:104341398_A_T rs1165695 cis 12 104341398 A T 0.3073 0.4118 0.0128 3.11e-226 'Endoplasmin ENSG00000166598 'HSP90B1 intron_variant ENSG00000166598 ENSG00000166598 'HSP90B1 5 known suggestive_specific_pathway -0.037947 0.069244 0.583928940299177 no HSP90B1 Olink NEURO EXPLORATORY(v.3901) HSP90B1 chr12 103930107 103953931 1 7184 protein_coding 12:103947620 17513 415_1_2 SeqId_13114_50 'Lumican chr12:104408832_C_T$SeqId_13114_50 1 chr12:104408832_C_T rs117801489 trans 12 104408832 T C 0.9849 0.4296 0.0545 3.32e-15 'Lumican ENSG00000139329 'LUM missense_variant ENSG00000120820 ENSG00000120820 'GLT8D2 3 novel specific_pathway LUM chr12 91102629 91111494 -1 4060 protein_coding 12:104015054 12903560 415_1_5 SeqId_9126_171 'NT5D3 chr12:104173630_C_T$SeqId_9126_171 1 chr12:104173630_C_T rs954921 cis 12 104173630 T C 0.6049 -0.6063 0.0123 3.90e-530 '5'-nucleotidase domain-containing protein 3 ENSG00000111696 'NT5DC3 intron_variant ENSG00000111696 ENSG00000111696 'NT5DC3 3 novel specific_protein NT5DC3 chr12 103770453 103841234 -1 51559 protein_coding 12:103779852 61382 415_2_1 SeqId_7779_86 'CHSTB chr12:104981678_D_I$SeqId_7779_86 1 chr12:104981678_D_I rs61022741 cis 12 104981678 D I 0.4775 -0.3769 0.0129 6.26e-189 'Carbohydrate sulfotransferase 11 ENSG00000171310 'CHST11 intron_variant ENSG00000171310 ENSG00000171310 'CHST11 3 known specific_protein CHST11 chr12 104455295 104762014 1 50515 protein_coding 12:104587901 132606 416_1_1 SeqId_7201_5 'ISCU chr12:108955106_D_I$SeqId_7201_5 1 chr12:108955106_D_I rs17040770 cis 12 108955106 D I 0.1281 0.1823 0.0186 1.12e-22 'Iron-sulfur cluster assembly enzyme ISCU, mitochondrial ENSG00000136003 'ISCU 5_prime_UTR_variant 1.0 rs10778648 ENSG00000136003 'ISCU missense_variant ENSG00000136003 ENSG00000136003 'ISCU 3 novel specific_protein ISCU chr12 108562582 108569368 1 23479 protein_coding 12:108561331 1251 416_1_2 SeqId_11266_8 'SELPL chr12:109013956_A_G$SeqId_11266_8 1 chr12:109013956_A_G rs73191242 cis 12 109013956 A G 0.2015 -0.2317 0.0159 2.31e-48 'P-selectin glycoprotein ligand 1 ENSG00000110876 'SELPLG downstream_gene_variant 0.430023 rs63748999 ENSG00000110876 'SELPLG inframe_insertion ENSG00000110876 ENSG00000110876 'SELPLG 3 known specific_protein SELPLG chr12 108621895 108633894 -1 6404 protein_coding 12:108620180 13714 416_2_1 SeqId_17783_9 'MMAB chr12:109988723_A_G$SeqId_17783_9 1 chr12:109988723_A_G rs76118041 cis 12 109988723 A G 0.1764 -0.8223 0.0152 4.48e-638 'Cob(I)yrinic acid a,c-diamide adenosyltransferase, mitochondrial ENSG00000139428 'MMAB downstream_gene_variant 0.196529 rs9593 ENSG00000139428 'MMAB missense_variant ENSG00000139428 ENSG00000139428 'MMAB 3 novel specific_protein MMAB chr12 109553715 109573580 -1 326625 protein_coding 12:109550918 22662 416_3_1 SeqId_10365_132 'IL-23 chr12:111932800_C_T$SeqId_10365_132 1 chr12:111932800_C_T rs7137828 trans 12 111932800 T C 0.5306 -0.1063 0.0134 1.88e-15 'Interleukin-23 ENSG00000113302|ENSG00000110944 'IL12B|IL23A intron_variant 0.178242 rs139032867 ENSG00000198324 'FAM109A inframe_insertion ENSG00000204842|ENSG00000089248|ENSG00000111252 ENSG00000111252 'SH2B3 5 known unspecific_effect IL23A chr12 56334174 56340410 1 51561 protein_coding 12:111494996 55160822 416_3_1 SeqId_6022_57 'NELL2 chr12:111910219_A_G$SeqId_6022_57 1 chr12:111910219_A_G rs10774625 trans 12 111910219 A G 0.4814 -0.091 0.0128 1.28e-12 'Protein kinase C-binding protein NELL2 ENSG00000184613 'NELL2 intron_variant 0.185941 rs139032867 ENSG00000198324 'FAM109A inframe_insertion ENSG00000204842|ENSG00000122986 ENSG00000111252 'SH2B3 5 known unspecific_effect NELL2 chr12 44508275 44921848 -1 4753 protein_coding 12:111472415 66550567 416_3_1 SeqId_9950_229 'LAG-3 chr12:112007756_C_T$SeqId_9950_229 1 chr12:112007756_C_T rs653178 trans 12 112007756 T C 0.5289 -0.0963 0.0137 1.92e-12 'Lymphocyte activation gene 3 protein ENSG00000089692 'LAG3 intron_variant 0.175763 rs139032867 ENSG00000198324 'FAM109A inframe_insertion ENSG00000204842|ENSG00000179295 ENSG00000111252 'SH2B3 5 known unspecific_effect LAG3 chr12 6772512 6778455 1 3902 protein_coding 12:111569952 104797440 416_3_2 SeqId_18381_16 'ALDH-E2 chr12:112108905_D_I$SeqId_18381_16 1 chr12:112108905_D_I rs570600621 cis 12 112108905 D I 0.8208 0.2239 0.0173 1.83e-38 'Aldehyde dehydrogenase, mitochondrial ENSG00000111275 'ALDH2 intron_variant ENSG00000111275 ENSG00000111275 'ALDH2 3 known specific_protein ALDH2 chr12 111766887 111817532 1 217 protein_coding 12:111671102 95785 416_4_1 SeqId_17777_31 'SDSL chr12:113867073_C_G$SeqId_17777_31 1 chr12:113867073_C_G rs113152874 cis 12 113867073 C G 0.0284 1.397 0.0417 8.53e-246 'Serine dehydratase-like ENSG00000139410 'SDSL missense_variant ENSG00000139410 ENSG00000139410 'SDSL 3 novel specific_protein SDSL chr12 113422380 113438276 1 113675 protein_coding 12:113429268 6888 418_1_1 SeqId_12831_21 'TESC chr12:117479019_C_T$SeqId_12831_21 1 chr12:117479019_C_T rs59756806 cis 12 117479019 T C 0.6508 0.6989 0.0118 2.32e-764 'Calcineurin B homologous protein 3 ENSG00000088992 'TESC intron_variant ENSG00000088992 ENSG00000088992 'TESC 6 novel specific_pathway TESC chr12 117038923 117099479 -1 54997 protein_coding 12:117041214 58265 418_2_1 SeqId_4276_10 'prostatic binding protein chr12:118584885_A_G$SeqId_4276_10 1 chr12:118584885_A_G rs76597567 cis 12 118584885 A G 0.9899 1.4085 0.0611 1.54e-117 'Phosphatidylethanolamine-binding protein 1 ENSG00000089220 'PEBP1 downstream_gene_variant 0.954359 rs1050625 ENSG00000089220 'PEBP1 missense_variant ENSG00000089220 ENSG00000089220 'PEBP1 3 known specific_protein 0.58656 0.29476 0.0471519871336448 yes PEBP1 Olink DEVELOPMENT(v.3511) PEBP1 chr12 118136124 118145584 1 5037 protein_coding 12:118147080 10956 419_1_3 SeqId_5245_40 'AMPK a2b2g1 chr12:120109284_D_I$SeqId_5245_40 1 chr12:120109284_D_I rs138621699 trans 12 120109284 D I 0.0832 0.1719 0.0232 1.31e-13 'AMP Kinase (alpha2beta2gamma1) ENSG00000131791|ENSG00000181929|ENSG00000162409 'PRKAB2|PRKAG1|PRKAA2 intron_variant ENSG00000111725 ENSG00000111725 'PRKAB1 3 novel specific_protein PRKAG1 chr12 49002274 49018807 -1 5571 protein_coding 12:119671480 70652673 419_2_2 SeqId_13931_22 'PSMD9 chr12:122330480_A_G$SeqId_13931_22 1 chr12:122330480_A_G rs7971607 cis 12 122330480 A G 0.5735 0.1098 0.0137 1.13e-15 '26S proteasome non-ATPase regulatory subunit 9 ENSG00000110801 'PSMD9 intron_variant 0.536579 rs14259 ENSG00000110801 'PSMD9 missense_variant ENSG00000110801 ENSG00000110801 'PSMD9 3 novel specific_pathway PSMD9 chr12 121888732 121918297 1 5715 protein_coding 12:121892574 3842 42_1_1 SeqId_3858_5 'PPAC chr2:281178_C_G$SeqId_3858_5 1 chr2:281178_C_G rs7566279 cis 2 281178 C G 0.6499 -1.2016 0.0077 4.94e-5291 'Low molecular weight phosphotyrosine protein phosphatase ENSG00000143727 'ACP1 intron_variant 0.993857 rs79716074 ENSG00000143727 'ACP1 missense_variant ENSG00000143727 ENSG00000143727 'ACP1 3 known specific_protein ACP1 chr2 264140 278283 1 52 protein_coding 2:281178 17038 42_1_2 SeqId_13463_1 'PXDN chr2:1709779_A_G$SeqId_13463_1 1 chr2:1709779_A_G rs34008669 cis 2 1709779 A G 0.4894 -0.1395 0.013 5.93e-27 'Peroxidasin homolog ENSG00000130508 'PXDN intron_variant ENSG00000130508 ENSG00000130508 'PXDN 3 known specific_protein PXDN chr2 1631887 1744852 -1 7837 protein_coding 2:1706007 38845 420_1_1 SeqId_8890_9 'T132B chr12:126129607_D_I$SeqId_8890_9 1 chr12:126129607_D_I rs148179158 cis 12 126129607 D I 0.7535 0.1417 0.0142 2.25e-23 'Transmembrane protein 132B ENSG00000139364 'TMEM132B intron_variant 0.991529 rs61021440 ENSG00000139364 'TMEM132B missense_variant ENSG00000139364 ENSG00000139364 'TMEM132B 3 novel specific_protein TMEM132B chr12 125186386 125662377 1 114795 protein_coding 12:125645062 458676 421_1_1 SeqId_7173_141 'T132C chr12:128761300_C_T$SeqId_7173_141 1 chr12:128761300_C_T rs11608284 cis 12 128761300 T C 0.6535 0.1801 0.0136 9.02e-40 'Transmembrane protein 132C ENSG00000181234 'TMEM132C intron_variant ENSG00000181234 ENSG00000181234 'TMEM132C 3 known specific_protein TMEM132C chr12 128267170 128707911 1 92293 protein_coding 12:128276755 9585 421_2_1 SeqId_8890_9 'T132B chr12:129559421_C_T$SeqId_8890_9 1 chr12:129559421_C_T rs73159540 trans 12 129559421 T C 0.1048 -0.3228 0.0198 7.18e-60 'Transmembrane protein 132B ENSG00000139364 'TMEM132B missense_variant ENSG00000151952 ENSG00000151952 'TMEM132D 3 known specific_protein TMEM132B chr12 125186386 125662377 1 114795 protein_coding 12:129074876 3888490 421_2_2 SeqId_13416_8 'T132D chr12:130106271_A_G$SeqId_13416_8 1 chr12:130106271_A_G rs61943557 cis 12 130106271 A G 0.0588 0.4012 0.0263 2.38e-52 'Transmembrane protein 132D ENSG00000151952 'TMEM132D intron_variant ENSG00000151952 ENSG00000151952 'TMEM132D 3 known suggestive_specific_pathway TMEM132D chr12 129071725 129904025 -1 121256 protein_coding 12:129621726 282299 423_1_1 SeqId_5131_15 'TAJ chr13:24147620_D_I$SeqId_5131_15 1 chr13:24147620_D_I rs754106586 cis 13 24147620 D I 0.6974 -0.1433 0.0147 2.43e-22 'Tumor necrosis factor receptor superfamily member 19 ENSG00000127863 'TNFRSF19 intron_variant 0.109788 rs9550987 ENSG00000127863 'TNFRSF19 missense_variant ENSG00000127863 ENSG00000127863 'TNFRSF19 3 known specific_protein TNFRSF19 chr13 23570370 23676104 1 55504 protein_coding 13:23573482 3112 423_2_1 SeqId_16605_2 'C1T9A chr13:24932444_G_T$SeqId_16605_2 1 chr13:24932444_G_T rs9511206 cis 13 24932444 T G 0.6797 0.4182 0.0141 3.67e-192 'Complement C1q and tumor necrosis factor-related protein 9A ENSG00000240654 'C1QTNF9 intergenic_variant 0.215304 rs3751357 ENSG00000240654 'C1QTNF9 missense_variant ENSG00000240654 ENSG00000240654 'C1QTNF9 3 novel specific_protein C1QTNF9 chr13 24307166 24322535 1 338872 protein_coding 13:24358306 51140 423_3_1 SeqId_12536_46 'MTMR6 chr13:25823207_A_T$SeqId_12536_46 1 chr13:25823207_A_T rs7999040 cis 13 25823207 A T 0.8332 -0.1425 0.0181 3.11e-15 'Myotubularin-related protein 6 ENSG00000139505 'MTMR6 3_prime_UTR_variant 0.447257 rs149367120 ENSG00000139505 'MTMR6 splice_acceptor_variant ENSG00000139505 ENSG00000139505 'MTMR6 3 novel specific_protein MTMR6 chr13 25246222 25287488 -1 9107 protein_coding 13:25249069 38419 424_1_1 SeqId_7852_9 'IF3M chr13:28009920_C_G$SeqId_7852_9 1 chr13:28009920_C_G rs1218825 cis 13 28009920 C G 0.9516 0.2302 0.0291 2.45e-15 'Translation initiation factor IF-3, mitochondrial ENSG00000122033 'MTIF3 missense_variant ENSG00000122033 ENSG00000122033 'MTIF3 3 novel specific_protein MTIF3 chr13 27435643 27450591 -1 219402 protein_coding 13:27435783 14808 425_1_2 SeqId_5727_35 'B3GLT chr13:31874303_C_T$SeqId_5727_35 1 chr13:31874303_C_T rs1995970 cis 13 31874303 T C 0.7706 0.5769 0.0143 7.63e-356 'Beta-1,3-glucosyltransferase ENSG00000187676 'B3GALTL intron_variant 0.993067 rs1041073 ENSG00000187676 'B3GALTL missense_variant ENSG00000187676 ENSG00000187676 'B3GLCT 3 known specific_protein B3GLCT chr13 31199975 31332276 1 145173 protein_coding 13:31300166 100191 426_1_1 SeqId_15384_15 'KLOTHO chr13:33592313_C_T$SeqId_15384_15 1 chr13:33592313_C_T rs73176817 cis 13 33592313 T C 0.9136 -0.1661 0.0243 8.66e-12 'Klotho ENSG00000133116 'KL intron_variant ENSG00000133116 ENSG00000133116 'KL 3 novel specific_protein KL chr13 33016423 33066143 1 9365 protein_coding 13:33018175 1752 427_1_1 SeqId_17156_72 'DCAK1 chr13:36641930_C_T$SeqId_17156_72 1 chr13:36641930_C_T rs7982300 cis 13 36641930 T C 0.7756 -0.1956 0.0158 2.68e-35 'Serine/threonine-protein kinase DCLK1 ENSG00000133083 'DCLK1 intron_variant ENSG00000133083 ENSG00000133083 'DCLK1 3 novel specific_protein DCLK1 chr13 35768652 36131382 -1 9201 protein_coding 13:36067793 63589 428_1_1 SeqId_3457_57 'Periostin chr13:38123841_A_G$SeqId_3457_57 1 chr13:38123841_A_G rs4424789 cis 13 38123841 A G 0.3729 0.1235 0.0137 2.28e-19 'Periostin ENSG00000133110 'POSTN intergenic_variant ENSG00000133110 ENSG00000133110 'POSTN 3 known specific_protein POSTN chr13 37562583 37598844 -1 10631 protein_coding 13:37549704 49140 43_1_1 SeqId_4430_44 'Collectin Kidney 1 chr2:3640142_C_T$SeqId_4430_44 1 chr2:3640142_C_T rs6542680 cis 2 3640142 T C 0.8159 -0.8658 0.0156 1.95e-671 'Collectin-11 ENSG00000118004 'COLEC11 upstream_gene_variant ENSG00000118004 ENSG00000118004 'COLEC11 7 known unspecific_effect COLEC11 chr2 3594832 3644644 1 78989 protein_coding 2:3592552 2280 43_1_1 SeqId_3587_53 'BMP10 chr2:3640142_C_T$SeqId_3587_53 1 chr2:3640142_C_T rs6542680 trans 2 3640142 T C 0.8158 -0.1978 0.0171 8.82e-31 'Bone morphogenetic protein 10 ENSG00000163217 'BMP10 upstream_gene_variant ENSG00000118004 ENSG00000118004 'COLEC11 7 known unspecific_effect BMP10 chr2 68860909 68871397 -1 27302 protein_coding 2:3592552 65278845 43_1_1 SeqId_3037_62 'IL-1b chr2:3639921_C_G$SeqId_3037_62 1 chr2:3639921_C_G rs13402561 trans 2 3639921 C G 0.1904 0.489 0.0175 2.24e-171 'Interleukin-1 beta ENSG00000125538 'IL1B upstream_gene_variant ENSG00000118004 ENSG00000118004 'COLEC11 7 known unspecific_effect IL1B chr2 112829751 112836816 -1 3553 protein_coding 2:3592331 109244485 43_1_1 SeqId_9872_23 'CTNA2 chr2:3639921_C_G$SeqId_9872_23 1 chr2:3639921_C_G rs13402561 trans 2 3639921 C G 0.1905 0.157 0.0181 4.68e-18 'Catenin alpha-2 ENSG00000066032 'CTNNA2 upstream_gene_variant ENSG00000118004 ENSG00000118004 'COLEC11 7 known unspecific_effect CTNNA2 chr2 79185231 80648861 1 1496 protein_coding 2:3592331 75592900 43_1_2 SeqId_12457_10 'MTND chr2:3507086_A_G$SeqId_12457_10 1 chr2:3507086_A_G rs13393515 cis 2 3507086 A G 0.6474 -0.1784 0.0145 1.24e-34 '1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase ENSG00000182551 'ADI1 intron_variant ENSG00000182551 ENSG00000182551 'ADI1 3 novel specific_protein ADI1 chr2 3497366 3519531 -1 55256 protein_coding 2:3503315 16216 431_1_2 SeqId_3518_54 'TAFI chr13:46641081_A_T$SeqId_3518_54 1 chr13:46641081_A_T rs7336360 cis 13 46641081 A T 0.3282 0.7757 0.0125 7.70e-839 'Carboxypeptidase B2 ENSG00000080618 'CPB2 intron_variant 0.998476 rs3742264 ENSG00000080618 'CPB2 missense_variant ENSG00000080618 ENSG00000080618 'CPB2 7 known suggestive_specific_pathway CPB2 chr13 46053186 46105033 -1 1361 protein_coding 13:46066946 38087 431_1_4 SeqId_17231_1 'L-plastin chr13:46706926_C_G$SeqId_17231_1 1 chr13:46706926_C_G rs9534336 cis 13 46706926 C G 0.5681 -0.1294 0.0134 3.44e-22 'Plastin-2 ENSG00000136167 'LCP1 intron_variant ENSG00000136167 ENSG00000136167 'LCP1 3 known unspecific_effect LCP1 chr13 46125920 46211871 -1 3936 protein_coding 13:46132791 79080 431_1_5 SeqId_4984_83 'Esterase D chr13:47345630_C_T$SeqId_4984_83 1 chr13:47345630_C_T rs15303 cis 13 47345630 T C 0.018 -0.9285 0.0497 9.05e-78 'S-formylglutathione hydrolase ENSG00000139684 'ESD missense_variant,splice_region_variant ENSG00000139684 ENSG00000139684 'ESD 3 novel specific_protein ESD chr13 46771256 46797420 -1 2098 protein_coding 13:46771495 25925 432_1_1 SeqId_5621_64 'THSD1 chr13:52971517_C_T$SeqId_5621_64 1 chr13:52971517_C_T rs41292808 cis 13 52971517 T C 0.0265 1.5299 0.0389 2.69e-338 'Thrombospondin type-1 domain-containing protein 1 ENSG00000136114 'THSD1 missense_variant ENSG00000136114 ENSG00000136114 'THSD1 3 known specific_protein THSD1 chr13 52377167 52416373 -1 55901 protein_coding 13:52397382 18991 433_1_1 SeqId_10558_26 'PCDH9 chr13:67723553_A_G$SeqId_10558_26 1 chr13:67723553_A_G rs4883797 cis 13 67723553 A G 0.3146 0.1604 0.014 3.13e-30 'Protocadherin-9 ENSG00000184226 'PCDH9 intron_variant ENSG00000184226 ENSG00000184226 'PCDH9 3 novel specific_protein PCDH9 chr13 66302834 67230445 -1 5101 protein_coding 13:67149421 81024 436_1_1 SeqId_8874_53 'CLN5 chr13:77584886_A_G$SeqId_8874_53 1 chr13:77584886_A_G rs1773045 cis 13 77584886 A G 0.0725 -0.4344 0.0258 1.66e-63 'Ceroid-lipofuscinosis neuronal protein 5 ENSG00000102805 'CLN5 intron_variant 0.986083 rs1800209 ENSG00000102805 'CLN5 missense_variant ENSG00000102805 ENSG00000102805 'CLN5 3 known specific_protein CLN5 chr13 76990660 77019143 1 1203 protein_coding 13:77010751 20091 437_1_1 SeqId_16916_19 'SLIK6 chr13:85922446_D_I$SeqId_16916_19 1 chr13:85922446_D_I rs150325889 cis 13 85922446 D I 0.2208 -0.2408 0.0163 2.22e-49 'SLIT and NTRK-like protein 6 ENSG00000184564 'SLITRK6 intergenic_variant ENSG00000184564 ENSG00000184564 'SLITRK6 3 novel specific_protein SLITRK6 chr13 85792790 85806683 -1 84189 protein_coding 13:85348312 458371 438_1_1 SeqId_4568_17 'SLIK5 chr13:88703595_D_I$SeqId_4568_17 1 chr13:88703595_D_I rs34509844 cis 13 88703595 D I 0.2995 -0.1704 0.0137 2.31e-35 'SLIT and NTRK-like protein 5 ENSG00000165300 'SLITRK5 intergenic_variant ENSG00000165300 ENSG00000165300 'SLITRK5 3 novel specific_protein SLITRK5 chr13 87671371 87696272 1 26050 protein_coding 13:88051341 379970 439_1_1 SeqId_4991_12 'GPC5 chr13:92417058_C_T$SeqId_4991_12 1 chr13:92417058_C_T rs342706 cis 13 92417058 T C 0.7226 0.7847 0.0131 9.51e-782 'Glypican-5 ENSG00000179399 'GPC5 intron_variant ENSG00000179399 ENSG00000179399 'GPC5 3 known specific_protein 0.84423 0.06621 2.83139199579939e-32 yes GCP5 Olink NEUROLOGY(v.8011) GPC5 chr13 91398621 92873682 1 2262 protein_coding 13:91764804 366183 439_2_1 SeqId_5350_14 'GPC6 chr13:93883687_G_T$SeqId_5350_14 1 chr13:93883687_G_T rs201590953 cis 13 93883687 T G 0.7128 -0.1098 0.0147 8.07e-14 'Glypican-6 ENSG00000183098 'GPC6 intron_variant ENSG00000183098 ENSG00000183098 'GPC6 3 novel specific_protein GPC6 chr13 93226807 94408020 1 10082 protein_coding 13:93231434 4627 44_2_1 SeqId_17791_25 'HPCL1 chr2:10476228_C_T$SeqId_17791_25 1 chr2:10476228_C_T rs375285744 cis 2 10476228 T C 0.8463 -0.3697 0.0181 5.08e-93 'Hippocalcin-like protein 1 ENSG00000115756 'HPCAL1 intron_variant ENSG00000115756 ENSG00000115756 'HPCAL1 3 novel specific_protein HPCAL1 chr2 10302889 10427617 1 3241 protein_coding 2:10336102 33213 440_1_1 SeqId_5350_14 'GPC6 chr13:95034749_A_G$SeqId_5350_14 1 chr13:95034749_A_G rs1535692 cis 13 95034749 A G 0.1836 -0.1199 0.0169 1.51e-12 'Glypican-6 ENSG00000183098 'GPC6 missense_variant ENSG00000183098 ENSG00000183098 'GPC6 3 novel specific_protein GPC6 chr13 93226807 94408020 1 10082 protein_coding 13:94382495 1155688 440_2_3 SeqId_18896_23 'H6ST3 chr13:96729594_C_G$SeqId_18896_23 1 chr13:96729594_C_G rs816122 cis 13 96729594 C G 0.1068 -0.1638 0.0211 8.44e-15 'Heparan-sulfate 6-O-sulfotransferase 3 ENSG00000185352 'HS6ST3 intergenic_variant ENSG00000185352 ENSG00000185352 'HS6ST3 3 novel unspecific_effect HS6ST3 chr13 96090107 96839562 1 266722 protein_coding 13:96077340 12767 441_1_1 SeqId_10558_26 'PCDH9 chr13:101316378_A_G$SeqId_10558_26 1 chr13:101316378_A_G rs1283208 trans 13 101316378 A G 0.672 -0.1007 0.0137 2.38e-13 'Protocadherin-9 ENSG00000184226 'PCDH9 intron_variant 0.851469 rs946837 ENSG00000125247 'TMTC4 missense_variant ENSG00000125247 ENSG00000125247 'TMTC4 3 novel specific_protein PCDH9 chr13 66302834 67230445 -1 5101 protein_coding 13:100664124 33433679 443_1_2 SeqId_3077_66 'Coagulation Factor Xa chr13:113792170_A_T$SeqId_3077_66 1 chr13:113792170_A_T rs547138 cis 13 113792170 A T 0.6073 0.2116 0.0143 8.49e-50 'Coagulation factor Xa ENSG00000126218 'F10 intron_variant ENSG00000126218 ENSG00000126218 'F10 3 known suggestive_specific_pathway F10 chr13 113122799 113149529 1 2159 protein_coding 13:113137856 15057 443_1_2 SeqId_4878_3 'Coagulation Factor X chr13:113792170_A_T$SeqId_4878_3 1 chr13:113792170_A_T rs547138 cis 13 113792170 A T 0.6073 0.2145 0.0142 1.84e-51 'Coagulation Factor X ENSG00000126218 'F10 intron_variant ENSG00000126218 ENSG00000126218 'F10 3 known suggestive_specific_pathway F10 chr13 113122799 113149529 1 2159 protein_coding 13:113137856 15057 443_1_3 SeqId_13934_3 'MCF2L chr13:113578421_C_T$SeqId_13934_3 1 chr13:113578421_C_T rs3011487 cis 13 113578421 T C 0.5865 -0.3999 0.0126 8.51e-222 'Guanine nucleotide exchange factor DBS ENSG00000126217 'MCF2L intron_variant ENSG00000126217 ENSG00000126217 'MCF2L 3 novel specific_protein MCF2L chr13 112894378 113099742 1 23263 protein_coding 13:112924107 29729 443_1_4 SeqId_3184_25 'Coagulation Factor VII chr13:113774092_A_G$SeqId_3184_25 1 chr13:113774092_A_G rs3093253 cis 13 113774092 A G 0.1089 -1.3799 0.0166 3.10e-1503 'Coagulation factor VII ENSG00000057593 'F7 3_prime_UTR_variant 0.993737 rs6046 ENSG00000057593 'F7 missense_variant ENSG00000057593 ENSG00000057593 'F7 3 known suggestive_specific_pathway -0.79579 0.095915 1.0715193052376e-15 yes F7 Olink CARDIOMETABOLIC(v.3602) F7 chr13 113105788 113120685 1 2155 protein_coding 13:113119778 13990 443_1_5 SeqId_15391_114 'GAS-6 chr13:114551993_C_T$SeqId_15391_114 1 chr13:114551993_C_T rs6602909 cis 13 114551993 T C 0.6651 0.2879 0.0136 6.0e-99 'Growth arrest-specific protein 6 ENSG00000183087 'GAS6 intron_variant ENSG00000183087 ENSG00000183087 'GAS6 3 novel specific_protein 0.25094 0.065544 0.000145780689505628 yes GAS6 Olink CARDIOMETABOLIC(v.3602) GAS6 chr13 113820549 113864076 -1 2621 protein_coding 13:113849020 15056 444_1_1 SeqId_15435_4 'PNP chr14:20940626_C_T$SeqId_15435_4 1 chr14:20940626_C_T rs1130650 cis 14 20940626 T C 0.1778 -0.1557 0.0162 8.2e-22 'Purine nucleoside phosphorylase ENSG00000198805 'PNP synonymous_variant 0.998865 rs1049564 ENSG00000198805 'PNP missense_variant ENSG00000198805 ENSG00000198805 'PNP 3 novel specific_protein PNP chr14 20468954 20477089 1 4860 protein_coding 14:20472467 3513 444_1_2 SeqId_5644_60 'RNAS4 chr14:21146584_C_T$SeqId_5644_60 1 chr14:21146584_C_T rs12588573 cis 14 21146584 T C 0.2181 -0.4407 0.0155 2.1e-177 'Ribonuclease 4 ENSG00000258818 'RNASE4 upstream_gene_variant ENSG00000258818 ENSG00000258818 'RNASE4 3 known suggestive_specific_pathway RNASE4 chr14 20684560 20701216 1 6038 protein_coding 14:20678425 6135 444_1_3 SeqId_4874_3 'Angiogenin chr14:21154495_C_G$SeqId_4874_3 1 chr14:21154495_C_G rs11851044 cis 14 21154495 C G 0.1159 0.8465 0.0186 3.03e-452 'Angiogenin ENSG00000214274 'ANG intron_variant ENSG00000214274 ENSG00000214274 'ANG 3 known suggestive_specific_pathway 0.61684 0.093672 1.18604181294802e-10 yes ANG Olink CARDIOMETABOLIC(v.3602) ANG chr14 20684177 20698971 1 283 protein_coding 14:20686336 2159 444_1_4 SeqId_5646_20 'RNAS6 chr14:21251586_A_C$SeqId_5646_20 1 chr14:21251586_A_C rs72669422 cis 14 21251586 A C 0.7635 -1.1675 0.0111 4.06e-2405 'Ribonuclease K6 ENSG00000169413 'RNASE6 downstream_gene_variant 0.996532 rs1045922 ENSG00000169413 'RNASE6 missense_variant ENSG00000169413 ENSG00000169413 'RNASE6 3 known specific_protein RNASE6 chr14 20781268 20782467 1 6039 protein_coding 14:20783427 2159 444_1_5 SeqId_7211_2 'RNase 1 chr14:21280678_A_G$SeqId_7211_2 1 chr14:21280678_A_G rs17254387 cis 14 21280678 A G 0.6909 0.2141 0.014 7.77e-53 'Ribonuclease pancreatic ENSG00000129538 'RNASE1 intergenic_variant ENSG00000129538 ENSG00000129538 'RNASE1 3 known specific_pathway RNASE1 chr14 20801228 20802855 -1 6035 protein_coding 14:20812519 9664 444_1_6 SeqId_8394_56 'RNase 2 chr14:21359808_A_C$SeqId_8394_56 1 chr14:21359808_A_C rs2233859 cis 14 21359808 A C 0.4291 0.3231 0.0135 9.11e-126 'Non-secretory ribonuclease ENSG00000169385 'RNASE2 intron_variant ENSG00000169385 ENSG00000169385 'RNASE2 3 known specific_pathway RNASE2 chr14 20955487 20956436 1 6036 protein_coding 14:20891649 63838 444_1_7 SeqId_15576_158 'ECP chr14:21385991_C_T$SeqId_15576_158 1 chr14:21385991_C_T rs147307766 cis 14 21385991 T C 0.0503 0.7662 0.0304 4.24e-140 'Eosinophil cationic protein ENSG00000169397 'RNASE3 intron_variant 0.138238 rs2073342 ENSG00000169397 'RNASE3 missense_variant ENSG00000169397 ENSG00000169397 'RNASE3 3 known specific_protein 0.75552 0.13785 6.83754188933792e-08 yes RNASE3 Olink METABOLISM(v.3402) RNASE3 chr14 20891385 20892348 1 6037 protein_coding 14:20917832 26447 444_2_1 SeqId_19253_82 'RAB2B chr14:21928759_A_G$SeqId_19253_82 1 chr14:21928759_A_G rs75162382 cis 14 21928759 A G 0.8652 0.1551 0.0197 3.16e-15 'Ras-related protein Rab-2B ENSG00000129472 'RAB2B 3_prime_UTR_variant 0.156415 rs61739513 ENSG00000092201 'SUPT16H missense_variant ENSG00000129472 ENSG00000129472 'RAB2B 7 novel specific_pathway RAB2B chr14 21459020 21476960 -1 84932 protein_coding 14:21460600 16360 445_1_2 SeqId_12572_236 'EFS chr14:23840033_C_T$SeqId_12572_236 1 chr14:23840033_C_T rs10137082 cis 14 23840033 T C 0.243 -0.1072 0.0152 1.53e-12 'Embryonal Fyn-associated substrate ENSG00000100842 'EFS upstream_gene_variant 0.282671 rs2231805 ENSG00000100842 'EFS missense_variant ENSG00000100842 ENSG00000100842 'EFS 3 novel specific_protein EFS chr14 23356403 23365752 -1 10278 protein_coding 14:23370824 5072 445_1_3 SeqId_12714_38 'AP1G2 chr14:24020127_A_C$SeqId_12714_38 1 chr14:24020127_A_C rs7159262 cis 14 24020127 A C 0.9123 0.3259 0.0226 4.38e-47 'AP-1 complex subunit gamma-like 2 ENSG00000213983 'AP1G2 intron_variant ENSG00000213983 ENSG00000213983 'AP1G2 3 novel specific_protein AP1G2 chr14 23559565 23568070 -1 8906 protein_coding 14:23550918 17152 445_1_4 SeqId_19446_1 'GMPR2 chr14:24707479_A_G$SeqId_19446_1 1 chr14:24707479_A_G rs34354104 cis 14 24707479 A G 0.048 -0.741 0.0292 1.15e-141 'GMP reductase 2 ENSG00000100938 'GMPR2 missense_variant ENSG00000100938 ENSG00000100938 'GMPR2 3 novel specific_protein GMPR2 chr14 24232422 24239242 1 51292 protein_coding 14:24238273 5851 445_2_1 SeqId_4133_54 'Granzyme B chr14:25096469_D_I$SeqId_4133_54 1 chr14:25096469_D_I rs35013088 cis 14 25096469 D I 0.1667 0.1361 0.018 3.53e-14 'Granzyme B ENSG00000100453 'GZMB downstream_gene_variant 0.164016 rs2236338 ENSG00000100453 'GZMB missense_variant ENSG00000100453 ENSG00000100453 'GZMB 3 known specific_protein GZMB chr14 24630954 24634267 -1 3002 protein_coding 14:24627264 7003 446_1_1 SeqId_7227_75 'COCH chr14:31343494_A_G$SeqId_7227_75 1 chr14:31343494_A_G rs28400019 cis 14 31343494 A G 0.1174 0.4953 0.0207 2.21e-126 'Cochlin ENSG00000100473 'COCH upstream_gene_variant ENSG00000100473 ENSG00000100473 'COCH 3 known specific_protein 0.48831 0.097881 8.48398710985997e-07 yes COCH Olink DEVELOPMENT(v.3511) COCH chr14 30874514 30895065 1 1690 protein_coding 14:30874288 226 446_1_2 SeqId_18280_29 'DTD2 chr14:31906728_A_C$SeqId_18280_29 1 chr14:31906728_A_C rs138832021 cis 14 31906728 A C 0.1261 -0.2292 0.0187 1.78e-34 'Putative D-tyrosyl-tRNA(Tyr) deacylase 2 ENSG00000129480 'DTD2 intron_variant ENSG00000129480 ENSG00000129480 'DTD2 3 novel specific_protein DTD2 chr14 31446036 31457506 -1 112487 protein_coding 14:31437522 19984 447_1_1 SeqId_15339_32 'COF2 chr14:35177730_D_I$SeqId_15339_32 1 chr14:35177730_D_I rs111787365 cis 14 35177730 D I 0.1519 0.1628 0.0187 3.2e-18 'Cofilin-2 ENSG00000165410 'CFL2 downstream_gene_variant ENSG00000165410 ENSG00000165410 'CFL2 3 novel specific_protein CFL2 chr14 34709113 34714823 -1 1073 protein_coding 14:34708525 6298 447_1_2 SeqId_8039_41 'F177A chr14:35516213_G_T$SeqId_8039_41 1 chr14:35516213_G_T rs799473 cis 14 35516213 T G 0.8403 -0.7237 0.0164 2.57e-425 'Protein FAM177A1 ENSG00000151327 'FAM177A1 intron_variant ENSG00000151327 ENSG00000151327 'FAM177A1 3 known specific_protein FAM177A1 chr14 35044907 35113130 1 283635 protein_coding 14:35047007 2100 448_1_1 SeqId_19372_7 'MDGA2 chr14:48306376_C_T$SeqId_19372_7 1 chr14:48306376_C_T rs61991840 trans 14 48306376 T C 0.8926 -0.5302 0.0202 1.42e-151 'MAM domain-containing glycosylphosphatidylinositol anchor protein 2 ENSG00000139915|ENSG00000272781 'MDGA2| intergenic_variant none ENSG00000272781 ' 1 novel specific_protein MDGA2 chr14 46839629 47675605 -1 161357 protein_coding 14:47837173 161568 448_2_1 SeqId_6909_40 'MGAT2 chr14:50025847_A_G$SeqId_6909_40 1 chr14:50025847_A_G rs7141096 cis 14 50025847 A G 0.5406 0.2122 0.0127 2.31e-62 'Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase ENSG00000168282 'MGAT2 intergenic_variant ENSG00000168282 ENSG00000168282 'MGAT2 3 known specific_protein MGAT2 chr14 49620799 49623481 1 4247 protein_coding 14:49559129 61670 448_3_1 SeqId_11441_11 'PYGL chr14:51403224_C_T$SeqId_11441_11 1 chr14:51403224_C_T rs148143618 cis 14 51403224 T C 0.0108 -0.7194 0.0649 1.48e-28 'Glycogen phosphorylase, liver form ENSG00000100504 'PYGL intron_variant 0.774837 rs35026927 ENSG00000100504 'PYGL missense_variant ENSG00000100504 ENSG00000100504 'PYGL 3 known specific_protein PYGL chr14 50857891 50944483 -1 5836 protein_coding 14:50936506 7977 448_4_1 SeqId_16060_99 'NID2 chr14:52487766_C_T$SeqId_16060_99 1 chr14:52487766_C_T rs2516600 cis 14 52487766 T C 0.4574 -0.791 0.0107 2.17e-1189 'Nidogen-2 ENSG00000087303 'NID2 intron_variant 0.271971 rs2101919 ENSG00000087303 'NID2 missense_variant ENSG00000087303 ENSG00000087303 'NID2 3 known specific_pathway -0.58314 0.055794 3.4276778654645e-23 yes NID2 Olink DEVELOPMENT(v.3511) NID2 chr14 52004809 52069059 -1 22795 protein_coding 14:52021048 48011 448_4_3 SeqId_13954_9 'GNA1 chr14:53168357_G_T$SeqId_13954_9 1 chr14:53168357_G_T rs12147912 cis 14 53168357 T G 0.0991 0.1698 0.0215 2.67e-15 'Glucosamine 6-phosphate N-acetyltransferase ENSG00000100522 'GNPNAT1 intergenic_variant ENSG00000100522 ENSG00000100522 'GNPNAT1 3 novel specific_protein GNPNAT1 chr14 52775193 52791668 -1 64841 protein_coding 14:52701639 90029 449_1_1 SeqId_3066_12 'Galectin-3 chr14:55612573_A_G$SeqId_3066_12 1 chr14:55612573_A_G rs76424323 cis 14 55612573 A G 0.919 0.7913 0.0224 2.62e-272 'Galectin-3 ENSG00000131981 'LGALS3 downstream_gene_variant 1.0 rs11125 ENSG00000131981 'LGALS3 missense_variant ENSG00000131981 ENSG00000131981 'LGALS3 3 known specific_protein 0.84678 0.12269 1.61808003764306e-11 yes Gal-3 Olink CARDIOVASCULAR III(v.6112) LGALS3 chr14 55124110 55145423 1 3958 protein_coding 14:55145855 21745 45_1_1 SeqId_19361_78 'MATN3 chr2:20207619_A_G$SeqId_19361_78 1 chr2:20207619_A_G rs11694716 cis 2 20207619 A G 0.6366 -0.5085 0.0128 3.99e-345 'Matrilin-3 ENSG00000132031 'MATN3 intron_variant ENSG00000132031 ENSG00000132031 'MATN3 3 novel specific_protein -0.69362 0.06004 2.0796966871037e-27 yes MATN3 Olink NEUROLOGY(v.8011) MATN3 chr2 19992052 20012668 -1 4148 protein_coding 2:20007858 4810 45_2_5 SeqId_2797_56 'Apo B chr2:21294975_A_G$SeqId_2797_56 1 chr2:21294975_A_G rs541041 cis 2 21294975 A G 0.8172 0.1332 0.0179 1.05e-13 'Apolipoprotein B ENSG00000084674 'APOB intergenic_variant 0.15407 rs12691202 ENSG00000084674 'APOB missense_variant ENSG00000084674 ENSG00000084674 'APOB 3 novel unspecific_effect APOB chr2 21001429 21044073 -1 338 protein_coding 2:21072103 28030 45_2_5 SeqId_6431_68 'PCYOX chr2:21291529_A_G$SeqId_6431_68 1 chr2:21291529_A_G rs668948 trans 2 21291529 A G 0.8188 0.144 0.0174 1.4e-16 'Prenylcysteine oxidase 1 ENSG00000116005 'PCYOX1 regulatory_region_variant 0.154248 rs12691202 ENSG00000084674 'APOB missense_variant none ENSG00000084674 'APOB 3 novel unspecific_effect PCYOX1 chr2 70257386 70281185 1 51449 protein_coding 2:21068657 49188729 450_1_1 SeqId_12575_30 'C1TC chr14:64857072_D_I$SeqId_12575_30 1 chr14:64857072_D_I rs377112209 cis 14 64857072 D I 0.4498 -0.1273 0.0129 6.74e-23 'C-1-tetrahydrofolate synthase, cytoplasmic ENSG00000100714 'MTHFD1 intron_variant ENSG00000100714 ENSG00000100714 'MTHFD1 3 known specific_protein MTHFD1 chr14 64388031 64463457 1 4522 protein_coding 14:64390355 2324 450_2_1 SeqId_8244_16 'FUT8 chr14:65796846_C_G$SeqId_8244_16 1 chr14:65796846_C_G rs2127870 cis 14 65796846 C G 0.7858 -1.1531 0.0116 1.54e-2148 'Alpha-(1,6)-fucosyltransferase ENSG00000033170 'FUT8 downstream_gene_variant 0.313615 rs35949016 ENSG00000033170 'FUT8 missense_variant ENSG00000033170 ENSG00000033170 'FUT8 3 known unspecific_effect -0.70889 0.070872 1.54881661891249e-21 yes FUT8 Olink NEURO EXPLORATORY(v.3901) FUT8 chr14 65410592 65744121 1 2530 protein_coding 14:65330128 80464 450_2_2 SeqId_12411_60 'MAX chr14:65544367_A_C$SeqId_12411_60 1 chr14:65544367_A_C rs762810 cis 14 65544367 A C 0.3535 -0.2277 0.0128 8.02e-71 'Protein max ENSG00000125952 'MAX intron_variant ENSG00000125952 ENSG00000125952 'MAX 3 known specific_pathway -0.15698 0.061604 0.0111403798733062 yes MAX Olink ORGAN DAMAGE(v.3301) MAX chr14 65006174 65102695 -1 4149 protein_coding 14:65077649 25046 451_1_2 SeqId_17752_24 'Arginase chr14:68089420_A_G$SeqId_17752_24 1 chr14:68089420_A_G rs61990120 cis 14 68089420 A G 0.1363 0.1891 0.0201 5.26e-21 'Arginase-2, mitochondrial ENSG00000081181 'ARG2 intron_variant ENSG00000081181 ENSG00000081181 'ARG2 3 novel specific_protein ARG2 chr14 67619920 67651708 1 384 protein_coding 14:67622703 2783 451_1_4 SeqId_8923_94 'GLTL1 chr14:69793475_A_G$SeqId_8923_94 1 chr14:69793475_A_G rs12100668 cis 14 69793475 A G 0.6057 0.1853 0.0133 3.48e-44 'Polypeptide N-acetylgalactosaminyltransferase 16 ENSG00000100626 'GALNT16 intron_variant 0.246965 rs12879377 ENSG00000100626 'GALNT16 missense_variant ENSG00000100626 ENSG00000100626 'GALNT16 3 known specific_protein GALNT16 chr14 69259277 69357033 1 57452 protein_coding 14:69326758 67481 451_1_5 SeqId_13118_5 'SMOC1 chr14:70354858_A_C$SeqId_13118_5 1 chr14:70354858_A_C rs1958078 cis 14 70354858 A C 0.1626 -0.3939 0.0172 1.15e-116 'SPARC-related modular calcium-binding protein 1 ENSG00000198732 'SMOC1 intron_variant ENSG00000198732 ENSG00000198732 'SMOC1 3 known specific_protein -0.55247 0.074916 7.211074791829e-13 yes SMOC1 Olink NEURO EXPLORATORY(v.3901) SMOC1 chr14 69854131 70032366 1 64093 protein_coding 14:69888141 34010 452_1_1 SeqId_19136_22 'MMSA chr14:74379073_A_G$SeqId_19136_22 1 chr14:74379073_A_G rs190138735 cis 14 74379073 A G 0.0124 -0.6151 0.0584 6.12e-26 'Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial ENSG00000119711 'ALDH6A1 intron_variant 0.540835 rs139579994 ENSG00000119711 'ALDH6A1 missense_variant ENSG00000119711 ENSG00000119711 'ALDH6A1 3 novel specific_protein ALDH6A1 chr14 74056847 74084492 -1 4329 protein_coding 14:73912370 172122 452_1_2 SeqId_4437_56 'ENTP5 chr14:74447785_C_G$SeqId_4437_56 1 chr14:74447785_C_G rs147326645 cis 14 74447785 C G 0.0592 -1.1686 0.0259 1.52e-444 'Ectonucleoside triphosphate diphosphohydrolase 5 ENSG00000187097 'ENTPD5 intron_variant ENSG00000187097 ENSG00000187097 'ENTPD5 3 known specific_protein -0.50324 0.12989 0.000121590599570883 yes ENTPD5 Olink METABOLISM(v.3402) ENTPD5 chr14 73958010 74019399 -1 957 protein_coding 14:73981082 38317 453_1_1 SeqId_16872_248 'MAAI chr14:77793207_A_G$SeqId_16872_248 1 chr14:77793207_A_G rs7975 cis 14 77793207 A G 0.3215 1.192 0.0091 8.83e-3729 'Maleylacetoacetate isomerase ENSG00000100577 'GSTZ1 missense_variant ENSG00000100577 ENSG00000100577 'GSTZ1 3 novel specific_protein GSTZ1 chr14 77320996 77331597 1 2954 protein_coding 14:77326864 5868 453_2_1 SeqId_16323_8 'NRX3A chr14:79587256_A_G$SeqId_16323_8 1 chr14:79587256_A_G rs7149325 cis 14 79587256 A G 0.6245 0.1411 0.0131 6.41e-27 'Neurexin-3 ENSG00000021645 'NRXN3 intron_variant ENSG00000021645 ENSG00000021645 'NRXN3 3 known specific_pathway NRXN3 chr14 78170373 79868291 1 9369 protein_coding 14:79120913 950540 453_2_1 SeqId_5111_15 'NRX3B chr14:79579859_A_G$SeqId_5111_15 1 chr14:79579859_A_G rs10141828 cis 14 79579859 A G 0.6332 0.1379 0.0133 3.65e-25 'Neurexin-3-beta ENSG00000021645 'NRXN3 intron_variant ENSG00000021645 ENSG00000021645 'NRXN3 3 known specific_pathway NRXN3 chr14 78170373 79868291 1 9369 protein_coding 14:79113516 943143 454_1_1 SeqId_13122_19 'FLRT2 chr14:85831823_G_T$SeqId_13122_19 1 chr14:85831823_G_T rs61980102 cis 14 85831823 T G 0.7105 0.2221 0.0138 2.68e-58 'Leucine-rich repeat transmembrane protein FLRT2 ENSG00000185070 'FLRT2 intron_variant,non_coding_transcript_variant ENSG00000185070 ENSG00000185070 'FLRT2 3 known specific_protein 0.23958 0.068172 0.00048250298005971 yes FLRT2 Olink NEUROLOGY(v.8011) FLRT2 chr14 85530144 85654428 1 23768 protein_coding 14:85365479 164665 455_1_2 SeqId_15585_304 'fibulin 5 chr14:92388714_A_G$SeqId_15585_304 1 chr14:92388714_A_G rs2402088 cis 14 92388714 A G 0.4269 0.1043 0.0137 2.54e-14 'Fibulin-5 ENSG00000140092 'FBLN5 intron_variant ENSG00000140092 ENSG00000140092 'FBLN5 3 novel specific_protein FBLN5 chr14 91869411 91947987 -1 10516 protein_coding 14:91922370 25617 455_1_3 SeqId_16825_20 'ATX3 chr14:92476005_A_G$SeqId_16825_20 1 chr14:92476005_A_G rs61988390 cis 14 92476005 A G 0.6731 0.3019 0.0135 4.55e-110 'Ataxin-3 ENSG00000066427 'ATXN3 intron_variant 0.631151 rs1048755 ENSG00000066427 'ATXN3 missense_variant ENSG00000066427 ENSG00000066427 'ATXN3 3 novel specific_protein ATXN3 chr14 92044496 92106621 -1 4287 protein_coding 14:92009661 96960 455_2_2 SeqId_8476_11 'CgA chr14:93401652_D_I$SeqId_8476_11 1 chr14:93401652_D_I rs148987265 cis 14 93401652 D I 0.1687 -0.2944 0.0176 8.43e-63 'Chromogranin-A ENSG00000100604 'CHGA downstream_gene_variant 0.935237 rs729940 ENSG00000100604 'CHGA missense_variant ENSG00000100604 ENSG00000100604 'CHGA 6 novel specific_pathway CHGA chr14 92923150 92935285 1 1113 protein_coding 14:92935308 12158 455_2_4 SeqId_3622_33 'LGMN chr14:93202028_C_T$SeqId_3622_33 1 chr14:93202028_C_T rs7157038 cis 14 93202028 T C 0.6773 0.1961 0.0142 1.41e-43 'Legumain ENSG00000100600 'LGMN intron_variant 0.284209 rs2236264 ENSG00000100600 'LGMN missense_variant ENSG00000100600 ENSG00000100600 'LGMN 3 novel suggestive_specific_pathway 0.23362 0.067726 0.00061066074047883 yes LGMN Olink DEVELOPMENT(v.3511) LGMN chr14 92703807 92748679 -1 5641 protein_coding 14:92735683 12996 456_1_1 SeqId_4437_56 'ENTP5 chr14:94838142_G_T$SeqId_4437_56 1 chr14:94838142_G_T rs112635299 trans 14 94838142 T G 0.0216 0.5393 0.0462 1.52e-31 'Ectonucleoside triphosphate diphosphohydrolase 5 ENSG00000187097 'ENTPD5 downstream_gene_variant 0.885854 rs28929474 ENSG00000197249 'SERPINA1 missense_variant ENSG00000197249 ENSG00000197249 'SERPINA1 8 known unspecific_effect 0.679 0.22658 0.00286945884307501 yes ENTPD5 Olink METABOLISM(v.3402) ENTPD5 chr14 73958010 74019399 -1 957 protein_coding 14:94371805 20352406 456_1_1 SeqId_3580_25 'a1-Antitrypsin chr14:94844947_C_T$SeqId_3580_25 1 chr14:94844947_C_T rs28929474 cis 14 94844947 T C 0.0208 -1.9024 0.0422 8.88e-444 'Alpha-1-antitrypsin ENSG00000197249 'SERPINA1 missense_variant ENSG00000197249 ENSG00000197249 'SERPINA1 8 known unspecific_effect SERPINA1 chr14 94376747 94390693 -1 5265 protein_coding 14:94378610 12083 456_1_11 SeqId_9002_36 'SPA11 chr14:94915948_A_T$SeqId_9002_36 1 chr14:94915948_A_T rs56026704 cis 14 94915948 A T 0.1701 -0.2932 0.0146 4.34e-89 'Serpin A11 ENSG00000186910 'SERPINA11 intron_variant 0.143143 rs1885137 ENSG00000186910 'SERPINA11 missense_variant ENSG00000186910 ENSG00000186910 'SERPINA11 3 known specific_pathway SERPINA11 chr14 94442464 94452800 -1 256394 protein_coding 14:94449611 3189 456_1_12 SeqId_6551_94 'Vaspin chr14:94988702_C_T$SeqId_6551_94 1 chr14:94988702_C_T rs4900235 cis 14 94988702 T C 0.2234 0.6235 0.0149 1.10e-382 'Serpin A12 ENSG00000165953 'SERPINA12 upstream_gene_variant ENSG00000165953 ENSG00000165953 'SERPINA12 3 known specific_pathway 0.77781 0.06795 5.35796657513341e-27 yes SERPINA12 Olink CARDIOVASCULAR II(v.5004) SERPINA12 chr14 94487274 94517844 -1 145264 protein_coding 14:94522365 4521 456_1_14 SeqId_3389_7 'PCI chr14:95054012_A_G$SeqId_3389_7 1 chr14:95054012_A_G rs6119 cis 14 95054012 A G 0.9 -0.5644 0.0216 6.86e-150 'Plasma serine protease inhibitor ENSG00000188488 'SERPINA5 missense_variant ENSG00000188488 ENSG00000188488 'SERPINA5 3 known suggestive_specific_pathway 0.23522 0.10062 0.019815270258051 no SERPINA5 Olink CARDIOMETABOLIC(v.3602) SERPINA5 chr14 94561442 94593118 1 5104 protein_coding 14:94587675 26233 456_1_2 SeqId_5002_76 'MMP-14 chr14:94849201_C_T$SeqId_5002_76 1 chr14:94849201_C_T rs709932 trans 14 94849201 T C 0.1612 -0.1903 0.0183 2.87e-25 'Matrix metalloproteinase-14 ENSG00000157227 'MMP14 missense_variant ENSG00000197249 ENSG00000197249 'SERPINA1 4 known unspecific_effect MMP14 chr14 22836560 22849041 1 4323 protein_coding 14:94382864 71546304 456_1_6 SeqId_3449_58 'Kallistatin chr14:95037778_A_G$SeqId_3449_58 1 chr14:95037778_A_G rs10146582 cis 14 95037778 A G 0.2143 0.6427 0.0152 1.12e-390 'Kallistatin ENSG00000100665 'SERPINA4 downstream_gene_variant ENSG00000100665 ENSG00000100665 'SERPINA4 4 known unspecific_effect SERPINA4 chr14 94561442 94569913 1 5267 protein_coding 14:94571441 9999 456_1_7 SeqId_13119_26 'protein Z inhibitor chr14:94755184_C_T$SeqId_13119_26 1 chr14:94755184_C_T rs12434093 cis 14 94755184 T C 0.8275 -0.945 0.0153 5.26e-831 'Protein Z-dependent protease inhibitor ENSG00000140093 'SERPINA10 intron_variant 0.997279 rs941591 ENSG00000140093 'SERPINA10 missense_variant ENSG00000140093 ENSG00000140093 'SERPINA10 6 known unspecific_effect SERPINA10 chr14 94280460 94293268 -1 51156 protein_coding 14:94288847 4421 456_1_8 SeqId_7266_4 'SPA9 chr14:94919677_D_I$SeqId_7266_4 1 chr14:94919677_D_I rs77569737 cis 14 94919677 D I 0.1689 0.1845 0.0168 5.04e-28 'Serpin A9 ENSG00000170054 'SERPINA9 upstream_gene_variant 0.928197 rs11628722 ENSG00000170054 'SERPINA9 missense_variant ENSG00000170054 ENSG00000170054 'SERPINA9 6 novel suggestive_specific_pathway SERPINA9 chr14 94462717 94479689 -1 327657 protein_coding 14:94453341 26348 456_1_9 SeqId_2879_9 'a1-Antichymotrypsin chr14:95097556_A_G$SeqId_2879_9 1 chr14:95097556_A_G rs8023057 cis 14 95097556 A G 0.8207 0.1688 0.0177 1.56e-21 'Alpha-1-antichymotrypsin ENSG00000196136 'SERPINA3 upstream_gene_variant ENSG00000196136 ENSG00000196136 'SERPINA3 3 known suggestive_specific_pathway SERPINA3 chr14 94612384 94624055 1 12 protein_coding 14:94631219 18835 456_1_9 SeqId_4153_11 'alpha-1-antichymotrypsin complex chr14:95097556_A_G$SeqId_4153_11 1 chr14:95097556_A_G rs8023057 cis 14 95097556 A G 0.8207 0.5171 0.0171 7.36e-200 'Alpha-1-antichymotrypsin complex ENSG00000196136 'SERPINA3 upstream_gene_variant ENSG00000196136 ENSG00000196136 'SERPINA3 3 known suggestive_specific_pathway SERPINA3 chr14 94612384 94624055 1 12 protein_coding 14:94631219 18835 456_2_1 SeqId_17210_2 'TCL1A chr14:96162418_A_G$SeqId_17210_2 1 chr14:96162418_A_G rs78986913 cis 14 96162418 A G 0.042 -0.5549 0.0335 1.04e-61 'T-cell leukemia/lymphoma protein 1A ENSG00000100721 'TCL1A downstream_gene_variant ENSG00000100721 ENSG00000100721 'TCL1A 3 novel specific_protein TCL1A chr14 95709947 95714196 -1 8115 protein_coding 14:95696081 18115 457_1_1 SeqId_6496_60 'DLK1 chr14:101176212_C_G$SeqId_6496_60 1 chr14:101176212_C_G rs12881545 cis 14 101176212 C G 0.6635 0.5327 0.0131 1.68e-361 'Protein delta homolog 1 ENSG00000185559 'DLK1 TF_binding_site_variant ENSG00000185559 ENSG00000185559 'DLK1 4 known unspecific_effect 0.42765 0.068458 9.19390474803981e-10 yes DLK-1 Olink CARDIOVASCULAR III(v.6112) DLK1 chr14 100725705 100738224 1 8788 protein_coding 14:100709875 15830 457_1_1 SeqId_6373_54 'DLK1 chr14:101176212_C_G$SeqId_6373_54 1 chr14:101176212_C_G rs12881545 none 14 101176212 C G 0.6635 0.5333 0.0131 2.60e-362 'Protein delta homolog 1 TF_binding_site_variant ENSG00000185559|ENSG00000214548 ENSG00000185559 'DLK1 4 known unspecific_effect DLK1 chr14 100725705 100738224 1 8788 protein_coding 14:100709875 15830 457_1_2 SeqId_11656_110 'EVL chr14:100421429_D_I$SeqId_11656_110 1 chr14:100421429_D_I rs75416067 cis 14 100421429 D I 0.7462 -0.687 0.015 5.55e-458 'Ena/VASP-like protein ENSG00000196405 'EVL intergenic_variant ENSG00000196405 ENSG00000196405 'EVL 3 novel specific_protein EVL chr14 99971449 100144236 1 51466 protein_coding 14:99955093 16356 457_1_3 SeqId_9870_17 'SYWC chr14:100837230_C_T$SeqId_9870_17 1 chr14:100837230_C_T rs4905957 cis 14 100837230 T C 0.7467 0.3586 0.0147 1.04e-131 'Tryptophan--tRNA ligase, cytoplasmic ENSG00000140105 'WARS intron_variant ENSG00000140105 ENSG00000140105 'WARS1 3 known specific_protein WARS1 chr14 100333790 100376805 -1 7453 protein_coding 14:100370893 5912 458_2_3 SeqId_12656_1 'KLC1 chr14:104121939_D_I$SeqId_12656_1 1 chr14:104121939_D_I rs142008283 cis 14 104121939 D I 0.3276 0.1453 0.0135 8.04e-27 'Kinesin light chain 1 ENSG00000126214 'KLC1 intron_variant ENSG00000126214 ENSG00000126214 'KLC1 3 known specific_protein KLC1 chr14 103561896 103714249 1 3831 protein_coding 14:103655603 93707 458_3_10 SeqId_4916_2 'IgD chr14:106291782_A_C$SeqId_4916_2 1 chr14:106291782_A_C rs10133571 cis 14 106291782 A C 0.5576 -0.1738 0.0163 2.14e-26 'Immunoglobulin D ENSG00000211898 'IGHD intergenic_variant 0.816339 rs709589 ENSG00000211898 'IGHD missense_variant ENSG00000211898 ENSG00000211898 ' 3 known unspecific_effect IGHD chr14 105836765 105845677 -1 IG_C_gene 14:105825449 20228 458_3_5 SeqId_13998_26 'PURA1 chr14:105186178_A_T$SeqId_13998_26 1 chr14:105186178_A_T rs72715968 cis 14 105186178 A T 0.7869 -0.4808 0.0156 1.35e-207 'Adenylosuccinate synthetase isozyme 1 ENSG00000185100 'ADSSL1 downstream_gene_variant 0.114776 rs80097179 ENSG00000185100 'ADSSL1 start_lost ENSG00000185100 ENSG00000185100 'ADSS1 3 novel specific_pathway ADSS1 chr14 104724229 104747325 1 122622 protein_coding 14:104719841 4388 458_3_8 SeqId_2744_57 'IgG chr14:106094912_A_C$SeqId_2744_57 1 chr14:106094912_A_C rs28572080 cis 14 106094912 A C 0.528 -0.1635 0.0168 2.64e-22 'Immunoglobulin G ENSG00000211896 'IGHG1 upstream_gene_variant 0.39141 rs1045853 ENSG00000211896 'IGHG1 missense_variant ENSG00000211896 ENSG00000211896 ' 3 known unspecific_effect IGHG1 chr14 105736343 105743071 -1 IG_C_gene 14:105628575 114496 458_4_6 SeqId_4137_57 'IL-17E chr14:106592308_A_C$SeqId_4137_57 1 chr14:106592308_A_C rs2106009 trans 14 106592308 A C 0.5649 -0.2066 0.0145 3.51e-46 'Interleukin-25 ENSG00000166090 'IL25 intergenic_variant 0.47991 rs11625174 ENSG00000211942 'IGHV3-13 missense_variant none none ' known suggestive_specific_pathway IL25 chr14 23372809 23376403 1 64806 protein_coding 14:106135717 82762908 46_1_1 SeqId_11568_2 'FKB1B chr2:24277709_A_G$SeqId_11568_2 1 chr2:24277709_A_G rs72781699 cis 2 24277709 A G 0.2027 -0.3642 0.0155 1.17e-121 'Peptidyl-prolyl cis-trans isomerase FKBP1B ENSG00000119782 'FKBP1B intron_variant ENSG00000119782 ENSG00000119782 'FKBP1B 3 novel suggestive_specific_pathway -0.4133 0.080319 3.88955574351741e-07 yes FKBP1B Olink ORGAN DAMAGE(v.3301) FKBP1B chr2 24049701 24063681 1 2281 protein_coding 2:24054839 5138 46_1_2 SeqId_17748_21 'QORX chr2:24342532_A_G$SeqId_17748_21 1 chr2:24342532_A_G rs1134516 cis 2 24342532 A G 0.1616 -0.6009 0.016 'Quinone oxidoreductase PIG3 ENSG00000115129 'TP53I3 synonymous_variant ENSG00000115129 ENSG00000115129 'TP53I3 3 novel suggestive_specific_pathway TP53I3 chr2 24077433 24085861 -1 9540 protein_coding 2:24119662 33801 46_2_1 SeqId_12799_65 'DJC27 chr2:25287948_D_I$SeqId_12799_65 1 chr2:25287948_D_I rs531054141 cis 2 25287948 D I 0.8762 -0.1533 0.0209 2.43e-13 'DnaJ homolog subfamily C member 27 ENSG00000115137 'DNAJC27 intron_variant ENSG00000115137 ENSG00000115137 'DNAJC27 3 novel specific_protein DNAJC27 chr2 24943636 24972094 -1 51277 protein_coding 2:25065080 92986 460_1_1 SeqId_18878_15 'GREM1 chr15:31386479_A_G$SeqId_18878_15 1 chr15:31386479_A_G rs117403031 trans 15 31386479 A G 0.0177 0.3998 0.0519 1.31e-14 'Gremlin-1 ENSG00000166923 'GREM1 intron_variant ENSG00000134160 ENSG00000134160 'TRPM1 1 novel specific_protein GREM1 chr15 32718004 32745106 1 26585 protein_coding 15:31094276 1623728 461_1_1 SeqId_18878_15 'GREM1 chr15:33001734_A_T$SeqId_18878_15 1 chr15:33001734_A_T rs58658771 cis 15 33001734 A T 0.1812 1.1048 0.0138 1.74e-1394 'Gremlin-1 ENSG00000166923 'GREM1 intergenic_variant ENSG00000166923 ENSG00000166923 'GREM1 4 novel suggestive_specific_pathway GREM1 chr15 32718004 32745106 1 26585 protein_coding 15:32709533 8471 462_1_1 SeqId_2828_82 'HAI-1 chr15:41145919_C_T$SeqId_2828_82 1 chr15:41145919_C_T rs17658212 cis 15 41145919 T C 0.0591 -0.3177 0.029 6.98e-28 'Kunitz-type protease inhibitor 1 ENSG00000166145 'SPINT1 synonymous_variant 0.305346 rs35070171 ENSG00000140323 'DISP2 missense_variant ENSG00000166145 ENSG00000166145 'SPINT1 5 known suggestive_specific_pathway SPINT1 chr15 40844018 40858207 1 6692 protein_coding 15:40853721 9703 462_1_2 SeqId_17737_7 'IVD chr15:40654038_A_G$SeqId_17737_7 1 chr15:40654038_A_G rs7165012 cis 15 40654038 A G 0.4605 -0.198 0.0127 9.16e-55 'Isovaleryl-CoA dehydrogenase, mitochondrial ENSG00000128928 'IVD intron_variant ENSG00000128928 ENSG00000128928 'IVD 3 novel specific_protein IVD chr15 40405485 40435947 1 3712 protein_coding 15:40361837 43648 462_1_3 SeqId_14655_1 'DJC17 chr15:41098339_C_T$SeqId_14655_1 1 chr15:41098339_C_T rs11070295 cis 15 41098339 T C 0.3454 -0.1568 0.0129 9.37e-34 'DnaJ homolog subfamily C member 17 ENSG00000104129 'DNAJC17 intron_variant ENSG00000104129 ENSG00000104129 'DNAJC17 3 novel specific_protein DNAJC17 chr15 40765161 40807478 -1 55192 protein_coding 15:40806141 1337 462_2_3 SeqId_13473_55 'IP3KA chr15:41795900_C_T$SeqId_13473_55 1 chr15:41795900_C_T rs316617 cis 15 41795900 T C 0.6328 -0.2308 0.0133 1.31e-67 'Inositol-trisphosphate 3-kinase A ENSG00000137825 'ITPKA 3_prime_UTR_variant ENSG00000137825 ENSG00000137825 'ITPKA 3 novel specific_protein ITPKA chr15 41493393 41503551 1 3706 protein_coding 15:41503702 10309 462_2_4 SeqId_2611_72 'Dtk chr15:41842078_C_G$SeqId_2611_72 1 chr15:41842078_C_G rs2588323 cis 15 41842078 C G 0.2955 0.1366 0.0139 7.96e-23 'Tyrosine-protein kinase receptor TYRO3 ENSG00000092445 'TYRO3 intergenic_variant 0.146589 rs12148316 ENSG00000092445 'TYRO3 missense_variant ENSG00000092445 ENSG00000092445 'TYRO3 3 known suggestive_specific_pathway TYRO3 chr15 41557675 41583589 1 7301 protein_coding 15:41549880 7795 463_2_2 SeqId_15447_45 'Sorbitol dehydrogenase chr15:45323474_C_T$SeqId_15447_45 1 chr15:45323474_C_T rs72722075 cis 15 45323474 T C 0.1309 0.3022 0.0197 4.33e-53 'Sorbitol dehydrogenase ENSG00000140263 'SORD intron_variant 0.457895 rs55739437 ENSG00000140263 'SORD missense_variant ENSG00000140263 ENSG00000140263 'SORD 3 novel specific_protein SORD chr15 45023147 45077185 1 6652 protein_coding 15:45031276 8129 463_2_3 SeqId_18188_12 'GATM chr15:45716425_C_T$SeqId_18188_12 1 chr15:45716425_C_T rs2433601 cis 15 45716425 T C 0.6282 0.4218 0.0126 1.52e-244 'Glycine amidinotransferase, mitochondrial ENSG00000171766 'GATM downstream_gene_variant 0.608767 rs1288775 ENSG00000171766 'GATM missense_variant ENSG00000171766 ENSG00000171766 'GATM 3 novel specific_protein GATM chr15 45361124 45402327 -1 2628 protein_coding 15:45424227 21900 464_1_5 SeqId_13450_49 'UBP8 chr15:50731131_D_I$SeqId_13450_49 1 chr15:50731131_D_I rs35912128 cis 15 50731131 D I 0.8254 -0.1383 0.0168 1.82e-16 'Ubiquitin carboxyl-terminal hydrolase 8 ENSG00000138592 'USP8 intron_variant 0.982928 rs11638390 ENSG00000138592 'USP8 missense_variant ENSG00000138592 ENSG00000138592 'USP8 3 novel unspecific_effect USP8 chr15 50424380 50514421 1 9101 protein_coding 15:50438935 14555 464_2_1 SeqId_7957_2 'SCG3 chr15:51979655_C_T$SeqId_7957_2 1 chr15:51979655_C_T rs1456295 cis 15 51979655 T C 0.7594 0.5312 0.014 1.07e-315 'Secretogranin-3 ENSG00000104112 'SCG3 intron_variant ENSG00000104112 ENSG00000104112 'SCG3 3 known specific_protein SCG3 chr15 51681492 51721026 1 29106 protein_coding 15:51687458 5966 465_1_1 SeqId_9964_10 'MYZAP chr15:57857245_C_T$SeqId_9964_10 1 chr15:57857245_C_T rs7162622 cis 15 57857245 T C 0.6841 -0.2534 0.0146 2.5e-67 'Myocardial zonula adherens protein ENSG00000263155 'MYZAP intergenic_variant ENSG00000263155 ENSG00000263155 'MYZAP 3 novel specific_protein MYZAP chr15 57591904 57685364 1 100820829 protein_coding 15:57565047 26857 465_2_3 SeqId_4455_89 'MFGM chr15:58680643_G_T$SeqId_4455_89 1 chr15:58680643_G_T rs35853021 trans 15 58680643 T G 0.3561 0.1017 0.0137 1.38e-13 'Lactadherin ENSG00000140545 'MFGE8 intron_variant ENSG00000137845 ENSG00000137845|ENSG00000166035 'ADAM10|LIPC 2 novel unspecific_effect MFGE8 chr15 88898683 88913381 -1 4240 protein_coding 15:58388444 30524937 466_1_2 SeqId_13700_10 'annexin II chr15:60689179_A_T$SeqId_13700_10 1 chr15:60689179_A_T rs8033800 cis 15 60689179 A T 0.6049 -0.781 0.0116 5.55e-987 'Annexin A2 ENSG00000182718 'ANXA2 intron_variant ENSG00000182718 ENSG00000182718 'ANXA2 3 known unspecific_effect ANXA2 chr15 60347134 60402883 -1 302 protein_coding 15:60396980 5903 466_1_3 SeqId_4961_17 'annexin II chr15:60715248_A_G$SeqId_4961_17 1 chr15:60715248_A_G rs34293839 cis 15 60715248 A G 0.8616 -0.8554 0.0168 1.73e-565 'Annexin A2 ENSG00000182718 'ANXA2 3_prime_UTR_variant ENSG00000182718 ENSG00000182718 'ANXA2 3 known unspecific_effect ANXA2 chr15 60347134 60402883 -1 302 protein_coding 15:60423049 20166 467_1_1 SeqId_4355_13 'DAPK2 chr15:64283076_A_G$SeqId_4355_13 1 chr15:64283076_A_G rs4436737 cis 15 64283076 A G 0.4214 0.3351 0.0128 2.48e-150 'Death-associated protein kinase 2 ENSG00000035664 'DAPK2 intron_variant ENSG00000035664 ENSG00000035664 'DAPK2 6 known specific_pathway DAPK2 chr15 63907036 64072033 -1 23604 protein_coding 15:63990877 81156 467_1_2 SeqId_6955_68 'SNX1 chr15:64428559_A_G$SeqId_6955_68 1 chr15:64428559_A_G rs1802376 cis 15 64428559 A G 0.0204 0.7712 0.047 1.62e-60 'Sorting nexin-1 ENSG00000028528 'SNX1 missense_variant ENSG00000028528 ENSG00000028528 'SNX1 3 novel specific_protein SNX1 chr15 64094123 64146090 1 6642 protein_coding 15:64136360 42237 467_2_3 SeqId_9793_145 'IGDC4 chr15:65693258_C_T$SeqId_9793_145 1 chr15:65693258_C_T rs35223184 cis 15 65693258 T C 0.0107 1.4863 0.064 3.37e-119 'Immunoglobulin superfamily DCC subclass member 4 ENSG00000103742 'IGDCC4 missense_variant ENSG00000103742 ENSG00000103742 'IGDCC4 3 known specific_protein IGDCC4 chr15 65381484 65422947 -1 57722 protein_coding 15:65400920 22027 467_2_4 SeqId_2864_2 'MEK1 chr15:66597110_G_T$SeqId_2864_2 1 chr15:66597110_G_T rs11854159 cis 15 66597110 T G 0.0731 0.1755 0.0255 6.14e-12 'Dual specificity mitogen-activated protein kinase kinase 1 ENSG00000169032 'MAP2K1 intron_variant ENSG00000169032 ENSG00000169032 'MAP2K1 3 novel specific_protein MAP2K1 chr15 66386837 66491656 1 5604 protein_coding 15:66304772 82065 468_1_1 SeqId_7808_5 'GLCE chr15:69536159_A_T$SeqId_7808_5 1 chr15:69536159_A_T rs35810867 cis 15 69536159 A T 0.229 -0.7785 0.0138 1.24e-693 'D-glucuronyl C5-epimerase ENSG00000138604 'GLCE intron_variant 0.99059 rs3865014 ENSG00000138604 'GLCE missense_variant ENSG00000138604 ENSG00000138604 'GLCE 3 known specific_protein GLCE chr15 69160584 69272217 1 26035 protein_coding 15:69243820 83236 469_1_1 SeqId_8900_28 'NEO1 chr15:73344196_C_G$SeqId_8900_28 1 chr15:73344196_C_G rs62016793 cis 15 73344196 C G 0.5961 0.2127 0.0133 3.29e-57 'Neogenin ENSG00000067141 'NEO1 5_prime_UTR_variant ENSG00000067141 ENSG00000067141 'NEO1 3 known specific_protein NEO1 chr15 73051710 73305205 1 4756 protein_coding 15:73051855 145 469_2_1 SeqId_13124_20 'ISLR2 chr15:74611189_C_T$SeqId_13124_20 1 chr15:74611189_C_T rs751527 cis 15 74611189 T C 0.6427 -0.1702 0.0135 2.34e-36 'Immunoglobulin superfamily containing leucine-rich repeat protein 2 ENSG00000167178 'ISLR2 intron_variant ENSG00000167178 ENSG00000167178 'ISLR2 3 known specific_protein -0.1491 0.063428 0.0191381520204743 yes ISLR2 Olink NEURO EXPLORATORY(v.3901) ISLR2 chr15 74100311 74138540 1 57611 protein_coding 15:74318848 218537 469_2_2 SeqId_12437_18 'ULK3 chr15:75135447_C_T$SeqId_12437_18 1 chr15:75135447_C_T rs2290574 cis 15 75135447 T C 0.2854 0.1746 0.0149 7.86e-32 'Serine/threonine-protein kinase ULK3 ENSG00000140474 'ULK3 5_prime_UTR_variant ENSG00000140474 ENSG00000140474 'ULK3 3 known specific_protein ULK3 chr15 74836118 74843346 -1 25989 protein_coding 15:74843106 240 469_2_4 SeqId_12633_3 'PTN9 chr15:75781554_A_G$SeqId_12633_3 1 chr15:75781554_A_G rs77716675 cis 15 75781554 A G 0.7449 0.1558 0.015 3.75e-25 'Tyrosine-protein phosphatase non-receptor type 9 ENSG00000169410 'PTPN9 intron_variant ENSG00000169410 ENSG00000169410 'PTPN9 3 novel unspecific_effect PTPN9 chr15 75463251 75579315 -1 5780 protein_coding 15:75489213 90102 469_2_5 SeqId_17765_3 'SPN1 chr15:75876597_D_I$SeqId_17765_3 1 chr15:75876597_D_I rs151128192 cis 15 75876597 D I 0.2451 0.2247 0.0145 2.9e-54 'Snurportin-1 ENSG00000169371 'SNUPN upstream_gene_variant ENSG00000169371 ENSG00000169371 'SNUPN 3 novel specific_protein SNUPN chr15 75598083 75626469 -1 10073 protein_coding 15:75584257 42212 469_3_1 SeqId_17435_43 'ETFA chr15:76492337_C_T$SeqId_17435_43 1 chr15:76492337_C_T rs79495512 cis 15 76492337 T C 0.9123 -0.5827 0.0229 2.0e-142 'Electron transfer flavoprotein subunit alpha, mitochondrial ENSG00000140374 'ETFA intron_variant 0.987195 rs1801591 ENSG00000140374 'ETFA missense_variant ENSG00000140374 ENSG00000140374 'ETFA 3 novel specific_protein ETFA chr15 76188555 76311730 -1 2108 protein_coding 15:76199996 111734 469_3_2 SeqId_6620_82 'LIGO1 chr15:78027178_C_T$SeqId_6620_82 1 chr15:78027178_C_T rs4886904 cis 15 78027178 T C 0.4167 0.0937 0.0133 2.1e-12 'Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 ENSG00000169783 'LINGO1 intron_variant ENSG00000169783 ENSG00000169783 'LINGO1 3 novel specific_protein LINGO1 chr15 77613027 77820900 -1 84894 protein_coding 15:77734836 86064 469_4_1 SeqId_8465_52 'Cathepsin H chr15:79237293_C_T$SeqId_8465_52 1 chr15:79237293_C_T rs2289702 cis 15 79237293 T C 0.1024 -1.2986 0.0184 2.79e-1084 'Cathepsin H ENSG00000103811 'CTSH missense_variant ENSG00000103811 ENSG00000103811 'CTSH 6 known specific_pathway -0.95437 0.098441 1.99526231496888e-20 yes CTSH Olink METABOLISM(v.3402) CTSH chr15 78921058 78949574 -1 1512 protein_coding 15:78944951 4623 469_4_2 SeqId_14107_1 'MTHFS chr15:80212149_A_C$SeqId_14107_1 1 chr15:80212149_A_C rs4994246 cis 15 80212149 A C 0.352 -0.4874 0.0128 5.27e-315 '5-formyltetrahydrofolate cyclo-ligase ENSG00000136371 'MTHFS intron_variant 0.124275 rs8923 ENSG00000136371 'MTHFS missense_variant ENSG00000136371 ENSG00000136371 'MTHFS 3 known specific_protein MTHFS chr15 79833585 79897379 -1 10588 protein_coding 15:79919807 22428 469_4_3 SeqId_11424_4 'FAAA chr15:80472526_C_T$SeqId_11424_4 1 chr15:80472526_C_T rs11555096 cis 15 80472526 T C 0.0188 -1.9185 0.0464 1.14e-373 'Fumarylacetoacetase ENSG00000103876 'FAH missense_variant ENSG00000103876 ENSG00000103876 'FAH 3 known specific_protein FAH chr15 80152490 80186946 1 2184 protein_coding 15:80180184 27694 469_4_4 SeqId_9504_19 'RB27A chr15:80825768_A_G$SeqId_9504_19 1 chr15:80825768_A_G rs4238522 trans 15 80825768 A G 0.6208 0.156 0.0139 3.33e-29 'Ras-related protein Rab-27A ENSG00000069974 'RAB27A intron_variant ENSG00000172379|ENSG00000140379 ENSG00000140379|ENSG00000172379 'ARNT2|BCL2A1 1 novel specific_protein RAB27A chr15 55202966 55319113 -1 5873 protein_coding 15:80533427 25214314 469_5_1 SeqId_2774_10 'IL-16 chr15:81595358_A_G$SeqId_2774_10 1 chr15:81595358_A_G rs58754882 cis 15 81595358 A G 0.0886 -1.0744 0.0212 3.01e-560 'Interleukin-16 ENSG00000172349 'IL16 intron_variant 0.985375 rs11556218 ENSG00000172349 'IL16 missense_variant ENSG00000172349 ENSG00000172349 'IL16 3 known specific_protein -0.70959 0.1045 3.31131121482591e-11 yes IL16 Olink CARDIOVASCULAR II(v.5004) IL16 chr15 81159575 81314058 1 3603 protein_coding 15:81303017 143442 469_5_2 SeqId_17383_4 'STAR5 chr15:81616559_C_T$SeqId_17383_4 1 chr15:81616559_C_T rs4392019 cis 15 81616559 T C 0.0352 1.2875 0.0332 5.57e-329 'StAR-related lipid transfer protein 5 ENSG00000172345 'STARD5 upstream_gene_variant ENSG00000172345 ENSG00000172345 'STARD5 3 novel suggestive_specific_pathway STARD5 chr15 81309053 81324183 -1 80765 protein_coding 15:81324218 35 47_1_1 SeqId_5223_59 'GCKR chr2:27730940_C_T$SeqId_5223_59 1 chr2:27730940_C_T rs1260326 cis 2 27730940 T C 0.4028 -0.3218 0.0134 7.31e-128 'Glucokinase regulatory protein ENSG00000084734 'GCKR missense_variant ENSG00000084734 ENSG00000084734 'GCKR 6 known unspecific_effect GCKR chr2 27496839 27523684 1 2646 protein_coding 2:27508073 11234 47_1_1 SeqId_8480_29 'FBLN3 chr2:27730940_C_T$SeqId_8480_29 1 chr2:27730940_C_T rs1260326 trans 2 27730940 T C 0.4029 -0.1197 0.0132 1.03e-19 'EGF-containing fibulin-like extracellular matrix protein 1 ENSG00000115380 'EFEMP1 missense_variant ENSG00000084734 ENSG00000084734 'GCKR 6 known unspecific_effect EFEMP1 chr2 55865967 55924139 -1 2202 protein_coding 2:27508073 28416066 47_1_1 SeqId_6561_77 'Ig K chain V-I region HK102-like chr2:27598097_C_T$SeqId_6561_77 1 chr2:27598097_C_T rs4665972 none 2 27598097 T C 0.4031 0.0993 0.0133 8.74e-14 'Ig Kappa chain V-I region HK102- like intron_variant 0.94722 rs1260326 ENSG00000084734 'GCKR missense_variant ENSG00000084734 ENSG00000084734 'GCKR 6 known unspecific_effect IGKV1D-42 chr2 90190193 90190681 1 IG_V_gene 2:27375230 62814963 470_1_1 SeqId_12685_57 'HOME2 chr15:83536665_A_G$SeqId_12685_57 1 chr15:83536665_A_G rs34347059 cis 15 83536665 A G 0.9282 0.2049 0.0257 1.69e-15 'Homer protein homolog 2 ENSG00000103942 'HOMER2 intron_variant 0.236619 rs3814281 ENSG00000156232 'WHAMM missense_variant ENSG00000103942 ENSG00000103942 'HOMER2 6 novel specific_pathway HOMER2 chr15 82836946 82986153 -1 9455 protein_coding 15:82867913 118240 470_2_1 SeqId_9321_400 'NMB chr15:85308141_G_T$SeqId_9321_400 1 chr15:85308141_G_T rs12903256 cis 15 85308141 T G 0.3492 -0.1618 0.0123 1.75e-39 'Neuromedin-B ENSG00000197696 'NMB intron_variant 0.660708 rs1051168 ENSG00000197696 'NMB missense_variant ENSG00000197696 ENSG00000197696 'NMB 3 known specific_protein NMB chr15 84655129 84658563 -1 4828 protein_coding 15:84764910 106347 471_1_1 SeqId_2658_27 'TrkC chr15:88514855_C_G$SeqId_2658_27 1 chr15:88514855_C_G rs28735437 cis 15 88514855 C G 0.1458 0.172 0.0186 1.97e-20 'NT-3 growth factor receptor ENSG00000140538 'NTRK3 intron_variant ENSG00000140538 ENSG00000140538 'NTRK3 3 known specific_protein NTRK3 chr15 87859751 88256768 -1 4916 protein_coding 15:87971624 285144 471_1_2 SeqId_3280_49 'Aggrecan chr15:89386652_A_G$SeqId_3280_49 1 chr15:89386652_A_G rs34949187 cis 15 89386652 A G 0.1847 -0.224 0.017 1.27e-39 'Aggrecan core protein ENSG00000157766 'ACAN missense_variant ENSG00000157766 ENSG00000157766 'ACAN 3 novel specific_protein -0.125 0.075004 0.0962498364017518 no ACAN Olink DEVELOPMENT(v.3511) ACAN chr15 88803436 88875353 1 176 protein_coding 15:88843421 39985 471_1_3 SeqId_4455_89 'MFGM chr15:89455768_C_G$SeqId_4455_89 1 chr15:89455768_C_G rs34239095 cis 15 89455768 C G 0.7261 -0.3104 0.0144 1.36e-102 'Lactadherin ENSG00000140545 'MFGE8 intron_variant 0.784689 rs4945 ENSG00000140545 'MFGE8 missense_variant ENSG00000140545 ENSG00000140545 'MFGE8 3 known specific_protein -0.3474 0.065028 1.41481612197132e-07 yes MFGE8 Olink DEVELOPMENT(v.3511) MFGE8 chr15 88898683 88913381 -1 4240 protein_coding 15:88912537 844 471_2_2 SeqId_13082_9 'UN45A chr15:91493207_C_T$SeqId_13082_9 1 chr15:91493207_C_T rs7173521 cis 15 91493207 T C 0.0283 -0.2643 0.0375 1.69e-12 'Protein unc-45 homolog A ENSG00000140553 'UNC45A intron_variant 0.969469 rs8041035 ENSG00000140553 'UNC45A missense_variant ENSG00000140553 ENSG00000140553 'UNC45A 3 novel specific_protein UNC45A chr15 90930180 90954093 1 55898 protein_coding 15:90949977 19797 472_1_1 SeqId_5483_1 'RGMA chr15:93609771_A_G$SeqId_5483_1 1 chr15:93609771_A_G rs4778091 cis 15 93609771 A G 0.4583 0.2094 0.0135 3.14e-54 'Repulsive guidance molecule A ENSG00000182175 'RGMA intron_variant 0.605919 rs4598860 ENSG00000182175 'RGMA missense_variant ENSG00000182175 ENSG00000182175 'RGMA 3 known suggestive_specific_pathway 0.36035 0.061082 6.89128164838054e-09 yes RGMA Olink NEUROLOGY(v.8011) RGMA chr15 93035271 93089211 -1 56963 protein_coding 15:93066542 22669 474_1_5 SeqId_6919_3 'HBAZ chr16:203254_A_G$SeqId_6919_3 1 chr16:203254_A_G rs2461286 cis 16 203254 A G 0.3515 0.6955 0.0124 1.05e-685 'Hemoglobin subunit zeta ENSG00000130656 'HBZ intron_variant ENSG00000130656 ENSG00000130656 'HBZ 3 known unspecific_effect HBZ chr16 142728 154503 1 3050 protein_coding 16:153255 10527 474_1_7 SeqId_16809_1 'NDKM chr16:444814_C_T$SeqId_16809_1 1 chr16:444814_C_T rs6600214 cis 16 444814 T C 0.3284 0.3594 0.0133 8.15e-162 'Nucleoside diphosphate kinase, mitochondrial ENSG00000103202 'NME4 upstream_gene_variant ENSG00000103202 ENSG00000103202 'NME4 3 novel unspecific_effect NME4 chr16 396725 410367 1 4833 protein_coding 16:394814 1911 474_1_8 SeqId_18343_10 'DECR2 chr16:456416_G_T$SeqId_18343_10 1 chr16:456416_G_T rs3743890 cis 16 456416 T G 0.4898 0.7342 0.0112 8.81e-936 'Peroxisomal 2,4-dienoyl-CoA reductase ENSG00000242612 'DECR2 intron_variant ENSG00000242612 ENSG00000242612 'DECR2 3 novel unspecific_effect DECR2 chr16 401858 412487 1 26063 protein_coding 16:406416 4558 474_1_9 SeqId_3191_50 'WFKN1 chr16:669708_G_T$SeqId_3191_50 1 chr16:669708_G_T rs55798945 cis 16 669708 T G 0.7014 -0.1133 0.0152 7.69e-14 'WAP, kazal, immunoglobulin, kunitz and NTR domain-containing protein 1 ENSG00000127578 'WFIKKN1 intron_variant ENSG00000127578 ENSG00000127578 'WFIKKN1 3 known unspecific_effect -0.25044 0.066342 0.000180052849969887 yes WFIKKN1 Olink NEUROLOGY(v.8011) WFIKKN1 chr16 629239 634117 1 117166 protein_coding 16:619708 9531 474_2_1 SeqId_6605_17 'IGFALS chr16:1838836_C_G$SeqId_6605_17 1 chr16:1838836_C_G rs1065656 cis 16 1838836 C G 0.3077 -0.2062 0.0136 9.83e-52 'Insulin-like growth factor-binding protein complex acid labile subunit ENSG00000099769 'IGFALS 3_prime_UTR_variant ENSG00000099769 ENSG00000099769 'IGFALS 5 known unspecific_effect IGFALS chr16 1790413 1794971 -1 3483 protein_coding 16:1788835 6136 474_2_10 SeqId_19367_34 'D3D2 chr16:2300154_C_G$SeqId_19367_34 1 chr16:2300154_C_G rs574891272 cis 16 2300154 C G 0.1547 -0.3411 0.0173 2.89e-86 'Enoyl-CoA delta isomerase 1, mitochondrial ENSG00000167969 'ECI1 intron_variant ENSG00000167969 ENSG00000167969 'ECI1 3 novel unspecific_effect ECI1 chr16 2239402 2252300 -1 1632 protein_coding 16:2250153 2147 474_2_2 SeqId_3403_1 'TPSB2 chr16:1280087_C_G$SeqId_3403_1 1 chr16:1280087_C_G rs143547788 cis 16 1280087 C G 0.438 -1.0062 0.0103 4.28e-2075 'Tryptase beta-2 ENSG00000172236 'TPSAB1 upstream_gene_variant 0.949815 rs144979264 ENSG00000172236 'TPSAB1 missense_variant ENSG00000172236 ENSG00000172236 'TPSAB1 3 known specific_protein TPSAB1 chr16 1240379 1242554 1 7177 protein_coding 16:1230086 10293 474_2_3 SeqId_9409_11 'TRYB1 chr16:1372070_A_C$SeqId_9409_11 1 chr16:1372070_A_C rs113690116 cis 16 1372070 A C 0.9787 -1.4262 0.0463 5.71e-208 'Tryptase beta-1 ENSG00000172236 'TPSAB1 intron_variant ENSG00000172236 ENSG00000172236 'TPSAB1 3 novel specific_protein -1.4935 0.21816 2.30674718872007e-11 yes TPSAB1 Olink IMMUNE RESPONSE(v.3202) TPSAB1 chr16 1240379 1242554 1 7177 protein_coding 16:1322069 81690 474_2_4 SeqId_10666_7 'GNPTG chr16:1407792_C_T$SeqId_10666_7 1 chr16:1407792_C_T rs4984644 cis 16 1407792 T C 0.0846 0.7976 0.0232 1.42e-259 'N-acetylglucosamine-1-phosphotransferase subunit gamma ENSG00000090581 'GNPTG intron_variant ENSG00000090581 ENSG00000090581 'GNPTG 3 known suggestive_specific_pathway GNPTG chr16 1351931 1365737 1 84572 protein_coding 16:1357791 5860 474_2_6 SeqId_17819_30 'FAHD1 chr16:1878031_A_G$SeqId_17819_30 1 chr16:1878031_A_G rs1143032 cis 16 1878031 A G 0.1589 0.7681 0.0161 9.61e-497 'Acylpyruvase FAHD1, mitochondrial ENSG00000180185 'FAHD1 intron_variant 1.0 rs3743853 ENSG00000180185 'FAHD1 missense_variant ENSG00000180185 ENSG00000180185 'FAHD1 3 known unspecific_effect FAHD1 chr16 1826941 1840207 1 81889 protein_coding 16:1828030 1089 474_2_7 SeqId_19267_14 'GLO2 chr16:1879423_C_T$SeqId_19267_14 1 chr16:1879423_C_T rs7185299 cis 16 1879423 T C 0.1427 0.2716 0.0191 1.15e-45 'Hydroxyacylglutathione hydrolase, mitochondrial ENSG00000063854 'HAGH intron_variant ENSG00000063854 ENSG00000063854 'HAGH 3 novel unspecific_effect HAGH chr16 1795620 1827157 -1 3029 protein_coding 16:1829422 2265 474_2_8 SeqId_9986_14 'Neuropeptide W chr16:2070433_A_G$SeqId_9986_14 1 chr16:2070433_A_G rs12921264 cis 16 2070433 A G 0.2227 -0.4954 0.015 2.73e-238 'Neuropeptide W ENSG00000183971 'NPW intron_variant 0.999029 rs11248906 ENSG00000183971 'NPW missense_variant ENSG00000183971 ENSG00000183971 'NPW 3 known specific_protein NPW chr16 2009926 2020755 1 283869 protein_coding 16:2020432 10506 474_2_9 SeqId_18235_16 'PGP chr16:2263836_C_T$SeqId_18235_16 1 chr16:2263836_C_T rs116977380 cis 16 2263836 T C 0.0405 0.8361 0.033 1.23e-141 'Glycerol-3-phosphate phosphatase ENSG00000184207 'PGP missense_variant ENSG00000184207 ENSG00000184207 'PGP 3 novel unspecific_effect PGP chr16 2211593 2214840 -1 283871 protein_coding 16:2213835 1005 474_3_1 SeqId_15535_3 'Marapsin chr16:2767894_G_T$SeqId_15535_3 1 chr16:2767894_G_T rs71386687 cis 16 2767894 T G 0.0803 0.3393 0.0268 9.93e-37 'Serine protease 27 ENSG00000172382 'PRSS27 intron_variant ENSG00000172382 ENSG00000172382 'PRSS27 3 novel specific_protein 0.58642 0.13203 1.10866413897996e-05 yes PRSS27 Olink CARDIOVASCULAR II(v.5004) PRSS27 chr16 2712419 2720551 -1 83886 protein_coding 16:2717893 2658 474_3_2 SeqId_8310_6 'U773 chr16:2885689_D_I$SeqId_8310_6 1 chr16:2885689_D_I rs56411639 cis 16 2885689 D I 0.3245 -0.1313 0.0149 1.23e-18 'Zymogen granule protein 16 homolog B ENSG00000162078 'ZG16B downstream_gene_variant ENSG00000162078 ENSG00000162078 'ZG16B 3 known specific_protein ZG16B chr16 2830253 2839585 1 124220 protein_coding 16:2835689 5436 474_3_3 SeqId_4534_10 'BSSP4 chr16:2910736_A_G$SeqId_4534_10 1 chr16:2910736_A_G rs7204669 cis 16 2910736 A G 0.3312 0.2628 0.0138 1.02e-80 'Brain-specific serine protease 4 ENSG00000005001 'PRSS22 upstream_gene_variant ENSG00000005001 ENSG00000005001 'PRSS22 3 known specific_protein PRSS22 chr16 2852730 2858170 -1 64063 protein_coding 16:2860735 2565 475_1_1 SeqId_10940_25 'SRCA chr16:4257281_A_C$SeqId_10940_25 1 chr16:4257281_A_C rs9922726 cis 16 4257281 A C 0.4318 0.1863 0.0135 4.86e-43 'Sarcalumenin ENSG00000185739 'SRL intron_variant ENSG00000185739 ENSG00000185739 'SRL 3 known suggestive_specific_pathway SRL chr16 4189374 4242080 -1 6345 protein_coding 16:4207280 34800 475_1_3 SeqId_13988_67 'NMRL1 chr16:4519439_A_G$SeqId_13988_67 1 chr16:4519439_A_G rs11557236 cis 16 4519439 A G 0.0852 -1.1035 0.021 3.83e-602 'NmrA-like family domain-containing protein 1 ENSG00000153406 'NMRAL1 missense_variant ENSG00000153406 ENSG00000153406 'NMRAL1 3 known specific_protein NMRAL1 chr16 4461691 4495763 -1 57407 protein_coding 16:4469438 26325 475_1_5 SeqId_11208_15 'NAGPA chr16:5079466_A_G$SeqId_11208_15 1 chr16:5079466_A_G rs12599777 cis 16 5079466 A G 0.8097 0.3013 0.0165 1.05e-74 'N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase ENSG00000103174 'NAGPA intron_variant 0.123909 rs7188856 ENSG00000103174 'NAGPA missense_variant ENSG00000103174 ENSG00000103174 'NAGPA 3 known specific_protein NAGPA chr16 5024844 5034141 -1 51172 protein_coding 16:5029465 4676 476_1_1 SeqId_17794_6 'Phosphomannomutase 2 chr16:8906539_A_C$SeqId_17794_6 1 chr16:8906539_A_C rs3826198 cis 16 8906539 A C 0.7941 -0.2582 0.0153 1.56e-63 'Phosphomannomutase 2 ENSG00000140650 'PMM2 intron_variant ENSG00000140650 ENSG00000140650 'PMM2 3 novel specific_protein PMM2 chr16 8788823 8862534 1 5373 protein_coding 16:8812682 23859 477_1_1 SeqId_2665_26 'BCMA chr16:12043512_G_T$SeqId_2665_26 1 chr16:12043512_G_T rs3850997 cis 16 12043512 T G 0.3225 -0.137 0.0143 9.73e-22 'Tumor necrosis factor receptor superfamily member 17 ENSG00000048462 'TNFRSF17 intron_variant ENSG00000048462 ENSG00000048462 'TNFRSF17 3 known specific_protein TNFRSF17 chr16 11965210 11968068 1 608 protein_coding 16:11949655 15555 479_1_2 SeqId_9765_4 'NDE1 chr16:15726293_A_C$SeqId_9765_4 1 chr16:15726293_A_C rs7206272 cis 16 15726293 A C 0.767 -0.126 0.0152 1.02e-16 'Nuclear distribution protein nudE homolog 1 ENSG00000072864 'NDE1 intron_variant ENSG00000072864 ENSG00000072864 'NDE1 3 novel specific_protein NDE1 chr16 15643267 15734691 1 54820 protein_coding 16:15632436 10831 48_2_1 SeqId_13943_38 'DPY30 chr2:32439307_A_G$SeqId_13943_38 1 chr2:32439307_A_G rs115631838 cis 2 32439307 A G 0.0489 0.2427 0.0304 1.38e-15 'Protein dpy-30 homolog ENSG00000162961 'DPY30 intron_variant ENSG00000162961 ENSG00000162961 'DPY30 3 known specific_protein DPY30 chr2 31867809 32039805 -1 84661 protein_coding 2:32214238 174433 481_1_1 SeqId_2829_19 'IL-27 chr16:28513068_D_I$SeqId_2829_19 1 chr16:28513068_D_I rs140934622 cis 16 28513068 D I 0.3347 -0.0994 0.0145 8.11e-12 'Interleukin-27 ENSG00000105246|ENSG00000197272 'EBI3|IL27 intron_variant 0.979009 rs181206 ENSG00000197272 'IL27 missense_variant ENSG00000105246|ENSG00000197272 ENSG00000105246|ENSG00000197272 'EBI3|IL27 3 known specific_protein IL27 chr16 28499362 28512051 -1 246778 protein_coding 16:28501748 10303 482_1_1 SeqId_2855_49 'ERK-1 chr16:30141913_A_G$SeqId_2855_49 1 chr16:30141913_A_G rs9931927 cis 16 30141913 A G 0.3318 0.4215 0.0132 1.31e-223 'Mitogen-activated protein kinase 3 ENSG00000102882 'MAPK3 regulatory_region_variant ENSG00000102882 ENSG00000102882 'MAPK3 3 known suggestive_specific_pathway MAPK3 chr16 30114105 30123506 -1 5595 protein_coding 16:30130592 7086 482_1_2 SeqId_13944_3 'SULT 1A3 chr16:30323168_C_G$SeqId_13944_3 1 chr16:30323168_C_G rs148788997 cis 16 30323168 C G 0.1293 0.3053 0.0192 4.05e-57 'Sulfotransferase 1A3 ENSG00000261052 'SULT1A3 intron_variant,non_coding_transcript_variant ENSG00000261052 ENSG00000261052 'SULT1A3 3 novel specific_pathway SULT1A3 chr16 30199228 30204310 1 6818 protein_coding 16:30311847 112619 482_1_3 SeqId_4314_12 'XTP3A chr16:30435601_C_G$SeqId_4314_12 1 chr16:30435601_C_G rs146094440 cis 16 30435601 C G 0.9852 0.4137 0.0583 1.26e-12 'dCTP pyrophosphatase 1 ENSG00000179958 'DCTPP1 missense_variant ENSG00000179958 ENSG00000179958 'DCTPP1 3 novel specific_protein DCTPP1 chr16 30423615 30430030 -1 79077 protein_coding 16:30424280 5750 482_1_5 SeqId_15513_108 'Prostasin chr16:31127672_D_I$SeqId_15513_108 1 chr16:31127672_D_I rs368991827 cis 16 31127672 D I 0.2783 0.0996 0.0146 9.32e-12 'Prostasin ENSG00000052344 'PRSS8 upstream_gene_variant ENSG00000052344 ENSG00000052344 'PRSS8 3 novel specific_protein PRSS8 chr16 31131433 31135727 -1 5652 protein_coding 16:31116352 19375 483_1_1 SeqId_9313_27 'CBLN1 chr16:49004958_A_G$SeqId_9313_27 1 chr16:49004958_A_G rs12596832 cis 16 49004958 A G 0.1389 -1.109 0.0158 1.79e-1072 'Cerebellin-1 ENSG00000102924 'CBLN1 intergenic_variant ENSG00000102924 ENSG00000102924 'CBLN1 3 known specific_protein CBLN1 chr16 49277917 49281838 -1 869 protein_coding 16:48971047 310791 484_1_4 SeqId_3508_78 'MDC chr16:57409934_G_T$SeqId_3508_78 1 chr16:57409934_G_T rs170364 cis 16 57409934 T G 0.2483 -0.199 0.0154 2.02e-38 'C-C motif chemokine 22 ENSG00000102962 'CCL22 intron_variant 0.147341 rs4359426 ENSG00000102962 'CCL22 missense_variant ENSG00000102962 ENSG00000102962 'CCL22 3 known specific_pathway CCL22 chr16 57358783 57366189 1 6367 protein_coding 16:57376022 17239 484_1_5 SeqId_2827_23 'Fractalkine/CX3CL-1 chr16:57434140_A_G$SeqId_2827_23 1 chr16:57434140_A_G rs62037103 cis 16 57434140 A G 0.01 0.7446 0.0688 2.55e-27 'Fractalkine ENSG00000006210 'CX3CL1 upstream_gene_variant 0.785958 rs62037084 ENSG00000006210 'CX3CL1 missense_variant ENSG00000006210 ENSG00000006210 'CX3CL1 3 known specific_protein CX3CL1 chr16 57372477 57385044 1 6376 protein_coding 16:57400228 27751 484_1_6 SeqId_3519_3 'TARC chr16:57444002_G_T$SeqId_3519_3 1 chr16:57444002_G_T rs16956811 cis 16 57444002 T G 0.9188 -0.4548 0.0242 1.3e-78 'C-C motif chemokine 17 ENSG00000102970 'CCL17 intron_variant ENSG00000102970 ENSG00000102970 'CCL17 3 known specific_protein -0.6793 0.11314 3.79053053942885e-09 yes CCL17 Olink CARDIOVASCULAR II(v.5004) CCL17 chr16 57404767 57416063 1 6361 protein_coding 16:57410090 5323 484_2_1 SeqId_18893_26 'GPR56 chr16:57689385_C_G$SeqId_18893_26 1 chr16:57689385_C_G rs1801257 cis 16 57689385 C G 0.5214 -0.1042 0.0133 4.26e-15 'Adhesion G-protein coupled receptor G1 ENSG00000205336 'GPR56 missense_variant ENSG00000205336 ENSG00000205336 'ADGRG1 3 novel specific_protein ADGRG1 chr16 57610652 57665580 1 9289 protein_coding 16:57655473 44821 485_1_1 SeqId_2819_23 'Cadherin-5 chr16:66428226_A_C$SeqId_2819_23 1 chr16:66428226_A_C rs1972838 cis 16 66428226 A C 0.3189 -0.1872 0.0143 3.25e-39 'Cadherin-5 ENSG00000179776 'CDH5 intron_variant 0.994848 rs1049970 ENSG00000179776 'CDH5 missense_variant ENSG00000179776 ENSG00000179776 'CDH5 3 novel specific_protein -0.15181 0.067229 0.0243837220968383 yes CDH5 Olink CARDIOVASCULAR III(v.6112) CDH5 chr16 66366622 66404784 1 1003 protein_coding 16:66394323 27701 485_1_2 SeqId_19114_8 'KITM chr16:66635531_A_G$SeqId_19114_8 1 chr16:66635531_A_G rs72790432 cis 16 66635531 A G 0.9167 -0.2366 0.024 5.16e-23 'Thymidine kinase 2, mitochondrial ENSG00000166548 'TK2 upstream_gene_variant ENSG00000166548 ENSG00000166548 'TK2 3 novel specific_protein TK2 chr16 66508003 66552544 -1 7084 protein_coding 16:66601628 49084 485_1_3 SeqId_18177_49 'ULA1 chr16:66743902_A_G$SeqId_18177_49 1 chr16:66743902_A_G rs7195900 cis 16 66743902 A G 0.0705 -0.1932 0.0264 2.3e-13 'NEDD8-activating enzyme E1 regulatory subunit ENSG00000159593 'NAE1 intergenic_variant ENSG00000159593 ENSG00000159593 'NAE1 3 novel specific_protein NAE1 chr16 66802875 66873256 -1 8883 protein_coding 16:66709999 163257 485_1_5 SeqId_2813_11 'ART chr16:67499714_C_T$SeqId_2813_11 1 chr16:67499714_C_T rs3892816 cis 16 67499714 T C 0.9537 -0.5231 0.0306 1.45e-65 'Agouti-related protein ENSG00000159723 'AGRP intron_variant 0.967396 rs5030980 ENSG00000159723 'AGRP missense_variant ENSG00000159723 ENSG00000159723 'AGRP 3 known unspecific_effect AGRP chr16 67482571 67483547 -1 181 protein_coding 16:67465811 17736 485_1_6 SeqId_8327_26 'DPEP2 chr16:68020063_C_G$SeqId_8327_26 1 chr16:68020063_C_G rs1107767 cis 16 68020063 C G 0.0487 -0.3876 0.0293 6.49e-40 'Dipeptidase 2 ENSG00000167261 'DPEP2 downstream_gene_variant 1.0 rs1133090 ENSG00000167261 'DPEP2 missense_variant ENSG00000167261 ENSG00000167261 'DPEP2 3 known unspecific_effect -0.4506 0.13767 0.00114024978756117 yes DPEP2 Olink NEURO EXPLORATORY(v.3901) DPEP2 chr16 67987394 68000586 -1 64174 protein_coding 16:67986160 14426 485_2_1 SeqId_18813_15 'DD19A chr16:70358495_A_G$SeqId_18813_15 1 chr16:70358495_A_G rs61757207 cis 16 70358495 A G 0.9873 0.5362 0.0582 3.22e-20 'ATP-dependent RNA helicase DDX19A ENSG00000168872 'DDX19A missense_variant ENSG00000168872 ENSG00000157349|ENSG00000168872 'DDX19A|DDX19B 3 novel suggestive_specific_pathway DDX19A chr16 70346861 70373383 1 55308 protein_coding 16:70324592 22269 485_2_1 SeqId_5460_60 'DEAD-box protein 19B chr16:70358495_A_G$SeqId_5460_60 1 chr16:70358495_A_G rs61757207 cis 16 70358495 A G 0.9873 0.5903 0.0585 6.55e-24 'ATP-dependent RNA helicase DDX19B ENSG00000157349 'DDX19B missense_variant ENSG00000157349 ENSG00000157349|ENSG00000168872 'DDX19A|DDX19B 3 novel suggestive_specific_pathway DDX19B chr16 70289663 70335305 1 11269 protein_coding 16:70324592 34929 485_2_2 SeqId_9837_60 'NAD(P)H dehydrogenase chr16:69736851_A_G$SeqId_9837_60 1 chr16:69736851_A_G rs12232410 cis 16 69736851 A G 0.1915 -0.9513 0.0146 1.54e-924 'NAD(P)H dehydrogenase [quinone] 1 ENSG00000181019 'NQO1 3_prime_UTR_variant 0.99219 rs1800566 ENSG00000181019 'NQO1 missense_variant ENSG00000181019 ENSG00000181019 'NQO1 3 known specific_protein NQO1 chr16 69706996 69726668 -1 1728 protein_coding 16:69702948 23720 485_2_3 SeqId_12340_17 'SYAC chr16:70191068_A_T$SeqId_12340_17 1 chr16:70191068_A_T rs4985404 cis 16 70191068 A T 0.9732 -0.3424 0.0423 5.38e-16 'Alanine--tRNA ligase, cytoplasmic ENSG00000090861 'AARS 3_prime_UTR_variant 0.291757 rs148355156 ENSG00000090861 'AARS missense_variant ENSG00000090861 ENSG00000090861 'AARS1 3 novel suggestive_specific_pathway AARS1 chr16 70251983 70289707 -1 16 protein_coding 16:70157165 132542 485_3_1 SeqId_3054_3 'Haptoglobin, Mixed Type chr16:72079657_C_T$SeqId_3054_3 1 chr16:72079657_C_T rs77303550 cis 16 72079657 T C 0.1982 0.8375 0.0149 1.28e-688 'Haptoglobin ENSG00000257017 'HP intron_variant 0.149557 rs16973716 ENSG00000118557 'PMFBP1 missense_variant ENSG00000257017 ENSG00000257017 'HP 4 known unspecific_effect HP chr16 72054505 72061055 1 3240 protein_coding 16:72045758 8747 485_3_1 SeqId_7905_30 'HPT chr16:72079657_C_T$SeqId_7905_30 1 chr16:72079657_C_T rs77303550 cis 16 72079657 T C 0.1982 0.7856 0.0152 1.36e-582 'Haptoglobin ENSG00000257017 'HP intron_variant 0.149557 rs16973716 ENSG00000118557 'PMFBP1 missense_variant ENSG00000257017 ENSG00000257017 'HP 4 known unspecific_effect HP chr16 72054505 72061055 1 3240 protein_coding 16:72045758 8747 485_3_4 SeqId_18876_77 'CHST4 chr16:71526091_C_T$SeqId_18876_77 1 chr16:71526091_C_T rs58134724 cis 16 71526091 T C 0.2902 0.1635 0.0147 1.2e-28 'Carbohydrate sulfotransferase 4 ENSG00000140835 'CHST4 upstream_gene_variant ENSG00000140835 ENSG00000140835 'CHST4 3 known suggestive_specific_pathway CHST4 chr16 71525233 71538748 1 10164 protein_coding 16:71492188 33045 485_3_5 SeqId_15316_262 'TXN4B chr16:72105560_C_T$SeqId_15316_262 1 chr16:72105560_C_T rs116891509 cis 16 72105560 T C 0.075 0.4246 0.0239 1.36e-70 'Thioredoxin-like protein 4B ENSG00000140830 'TXNL4B intron_variant ENSG00000140830 ENSG00000140830 'TXNL4B 3 known suggestive_specific_pathway TXNL4B chr16 72044289 72094431 -1 54957 protein_coding 16:72071661 22770 486_1_1 SeqId_11608_5 'MLP3B chr16:75750016_D_I$SeqId_11608_5 1 chr16:75750016_D_I rs111346751 trans 16 75750016 D I 0.1204 -0.1662 0.0208 1.42e-15 'Microtubule-associated proteins 1A/1B light chain 3B ENSG00000140941 'MAP1LC3B intron_variant 0.337209 rs3743599 ENSG00000065457 'ADAT1 missense_variant ENSG00000034713 ENSG00000034713 'GABARAPL2 2 known specific_pathway MAP1LC3B chr16 87383953 87404779 1 81631 protein_coding 16:75716119 11667834 486_1_3 SeqId_5671_1 'Chymotrypsin chr16:75255217_A_G$SeqId_5671_1 1 chr16:75255217_A_G rs8051363 cis 16 75255217 A G 0.2747 -0.4899 0.0144 1.15e-252 'Chymotrypsinogen B ENSG00000168925 'CTRB1 intron_variant ENSG00000168925 ENSG00000168925 'CTRB1 5 known unspecific_effect CTRB1 chr16 75218988 75226338 1 1504 protein_coding 16:75221319 2331 486_1_4 SeqId_12494_99 'GBRL2 chr16:75573514_A_T$SeqId_12494_99 1 chr16:75573514_A_T rs201560860 cis 16 75573514 A T 0.1174 -0.141 0.0195 4.66e-13 'Gamma-aminobutyric acid receptor-associated protein-like 2 ENSG00000034713 'GABARAPL2 upstream_gene_variant ENSG00000034713 ENSG00000034713 'GABARAPL2 3 known specific_pathway GABARAPL2 chr16 75566375 75577881 1 11345 protein_coding 16:75539616 26759 486_1_5 SeqId_5648_28 'CTRB2 chr16:75241676_D_I$SeqId_5648_28 1 chr16:75241676_D_I rs66584288 cis 16 75241676 D I 0.8009 -1.0037 0.014 8.68e-1119 'Chymotrypsinogen B2 ENSG00000168928 'CTRB2 upstream_gene_variant 0.896286 rs4737 ENSG00000168928 'CTRB2 missense_variant ENSG00000168928 ENSG00000168928 'CTRB2 3 known specific_pathway CTRB2 chr16 75204103 75207161 -1 440387 protein_coding 16:75207779 618 487_1_1 SeqId_17724_3 'WWOX chr16:78420775_A_G$SeqId_17724_3 1 chr16:78420775_A_G rs11545029 cis 16 78420775 A G 0.5915 -0.273 0.0133 4.66e-94 'WW domain-containing oxidoreductase ENSG00000186153 'WWOX missense_variant ENSG00000186153 ENSG00000186153 'WWOX 3 novel specific_protein WWOX chr16 78099400 79212667 1 51741 protein_coding 16:78386878 287478 489_2_1 SeqId_10070_22 'PLCG2 chr16:81870969_C_T$SeqId_10070_22 1 chr16:81870969_C_T rs12445050 cis 16 81870969 T C 0.136 0.3743 0.0185 1.09e-90 '1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 ENSG00000197943 'PLCG2 intron_variant ENSG00000197943 ENSG00000197943 'PLCG2 3 novel specific_protein PLCG2 chr16 81739097 81962685 1 5336 protein_coding 16:81837364 98267 49_1_1 SeqId_6234_74 'VITRN chr2:36993940_A_C$SeqId_6234_74 1 chr2:36993940_A_C rs1468810 cis 2 36993940 A C 0.591 -0.2841 0.0126 6.34e-113 'Vitrin ENSG00000205221 'VIT intron_variant ENSG00000205221 ENSG00000205221 'VIT 3 known specific_protein VIT chr2 36696690 36814794 1 5212 protein_coding 2:36766797 70107 49_1_2 SeqId_7849_3 'Glutaminyl cyclase chr2:37536488_A_G$SeqId_7849_3 1 chr2:37536488_A_G rs4670193 cis 2 37536488 A G 0.5386 -0.1966 0.0126 1.7e-54 'Glutaminyl-peptide cyclotransferase ENSG00000115828 'QPCT intron_variant ENSG00000115828 ENSG00000115828 'QPCT 3 known specific_protein -0.24869 0.061786 6.61149996541044e-05 yes QPCT Olink CARDIOMETABOLIC(v.3602) QPCT chr2 37342827 37373322 1 25797 protein_coding 2:37309345 33482 490_1_1 SeqId_11538_216 'DCMC chr16:83936496_C_T$SeqId_11538_216 1 chr16:83936496_C_T rs9931691 cis 16 83936496 T C 0.8211 0.1902 0.0162 1.2e-31 'Malonyl-CoA decarboxylase, mitochondrial ENSG00000103150 'MLYCD intron_variant 0.193489 rs138107830 ENSG00000103150 'MLYCD missense_variant ENSG00000103150 ENSG00000103150 'MLYCD 3 novel specific_protein MLYCD chr16 83899115 83951445 1 23417 protein_coding 16:83902891 3776 490_1_2 SeqId_9316_67 'WFDC1 chr16:84328494_C_T$SeqId_9316_67 1 chr16:84328494_C_T rs400345 cis 16 84328494 T C 0.178 -0.5287 0.017 1.45e-212 'WAP four-disulfide core domain protein 1 ENSG00000103175 'WFDC1 5_prime_UTR_variant ENSG00000103175 ENSG00000103175 'WFDC1 3 known specific_protein WFDC1 chr16 84294846 84329844 1 58189 protein_coding 16:84294888 42 490_2_1 SeqId_5691_2 'CRLD2 chr16:84914002_C_T$SeqId_5691_2 1 chr16:84914002_C_T rs183935383 cis 16 84914002 T C 0.0101 -0.6772 0.0679 2.03e-23 'Cysteine-rich secretory protein LCCL domain-containing 2 ENSG00000103196 'CRISPLD2 intron_variant ENSG00000103196 ENSG00000103196 'CRISPLD2 3 known specific_protein CRISPLD2 chr16 84819985 84920768 1 83716 protein_coding 16:84880396 60411 491_2_1 SeqId_19129_15 'MTHFSD chr16:86568701_A_T$SeqId_19129_15 1 chr16:86568701_A_T rs11642368 cis 16 86568701 A T 0.5935 0.527 0.0122 1.20e-407 'Methenyltetrahydrofolate synthase domain-containing protein ENSG00000103248 'MTHFSD intron_variant 0.21726 rs3751802 ENSG00000103248 'MTHFSD missense_variant ENSG00000103248 ENSG00000103248 'MTHFSD 3 novel specific_protein MTHFSD chr16 86530178 86555235 -1 64779 protein_coding 16:86535095 20140 492_1_5 SeqId_18422_41 'ERG19 chr16:88715560_A_T$SeqId_18422_41 1 chr16:88715560_A_T rs7205773 cis 16 88715560 A T 0.0114 -0.5916 0.0704 4.19e-17 'Diphosphomevalonate decarboxylase ENSG00000167508 'MVD intron_variant ENSG00000167508 ENSG00000167508 'MVD 3 novel specific_protein MVD chr16 88651935 88663161 -1 4597 protein_coding 16:88649152 14009 492_2_1 SeqId_8794_13 'DPEP1 chr16:89682350_A_G$SeqId_8794_13 1 chr16:89682350_A_G rs409170 cis 16 89682350 A G 0.3967 -0.5277 0.0129 8.32e-366 'Dipeptidase 1 ENSG00000015413 'DPEP1 upstream_gene_variant 0.226116 rs1126464 ENSG00000015413 'DPEP1 missense_variant ENSG00000015413 ENSG00000015413 'DPEP1 3 known specific_protein -0.7124 0.055128 5.00034534976976e-33 yes DPEP1 Olink NEURO EXPLORATORY(v.3901) DPEP1 chr16 89613308 89638456 1 1800 protein_coding 16:89615942 2634 493_1_1 SeqId_5129_12 'SREC-I chr17:1542190_A_G$SeqId_5129_12 1 chr17:1542190_A_G rs2272011 cis 17 1542190 A G 0.5939 -0.2865 0.0124 2.77e-118 'Scavenger receptor class F member 1 ENSG00000074660 'SCARF1 missense_variant ENSG00000074660 ENSG00000074660 'SCARF1 3 known specific_protein -0.091898 0.060128 0.127069113479764 no SCARF1 Olink DEVELOPMENT(v.3511) SCARF1 chr17 1633858 1645744 -1 8578 protein_coding 17:1638896 6848 493_1_2 SeqId_3024_18 'a2-Antiplasmin chr17:1618363_C_T$SeqId_3024_18 1 chr17:1618363_C_T rs11078597 cis 17 1618363 T C 0.8076 0.3283 0.0167 2.01e-86 'Alpha-2-antiplasmin ENSG00000167711 'SERPINF2 upstream_gene_variant 0.669113 rs2070863 ENSG00000167711 'SERPINF2 missense_variant ENSG00000167711 ENSG00000167711 'SERPINF2 3 known specific_protein SERPINF2 chr17 1742836 1755265 1 5345 protein_coding 17:1715069 27767 493_1_3 SeqId_9211_19 'PEDF chr17:1666253_C_T$SeqId_9211_19 1 chr17:1666253_C_T rs62088172 cis 17 1666253 T C 0.349 -0.367 0.013 2.47e-174 'Pigment epithelium-derived factor ENSG00000132386 'SERPINF1 intron_variant 0.936898 rs1136287 ENSG00000132386 'SERPINF1 missense_variant ENSG00000132386 ENSG00000132386 'SERPINF1 3 known specific_protein SERPINF1 chr17 1762029 1777565 1 5176 protein_coding 17:1762959 930 493_2_1 SeqId_17697_2 'OVCA2 chr17:1945354_A_C$SeqId_17697_2 1 chr17:1945354_A_C rs145234879 cis 17 1945354 A C 0.0155 0.6388 0.0568 2.38e-29 'Esterase OVCA2 ENSG00000262664 'OVCA2 synonymous_variant ENSG00000262664 ENSG00000262664 'OVCA2 3 novel specific_protein OVCA2 chr17 2042022 2043425 1 124641 protein_coding 17:2042060 38 494_1_1 SeqId_12498_12 'TX1B3 chr17:3558698_A_G$SeqId_12498_12 1 chr17:3558698_A_G rs467277 cis 17 3558698 A G 0.5222 0.1449 0.0127 2.71e-30 'Tax1-binding protein 3 ENSG00000213977 'TAX1BP3 intron_variant ENSG00000213977 ENSG00000213977 'TAX1BP3 3 novel specific_protein TAX1BP3 chr17 3662895 3668679 -1 30851 protein_coding 17:3655404 13275 494_2_1 SeqId_10924_258 'NEUFC chr17:4060233_A_G$SeqId_10924_258 1 chr17:4060233_A_G rs118123280 cis 17 4060233 A G 0.0165 -1.3895 0.0522 6.79e-156 'Neuferricin ENSG00000167740 'CYB5D2 missense_variant ENSG00000167740 ENSG00000167740 'CYB5D2 7 novel suggestive_specific_pathway CYB5D2 chr17 4143168 4187310 1 124936 protein_coding 17:4156939 13771 494_2_2 SeqId_18860_2 'CaMKK alpha chr17:3793472_C_T$SeqId_18860_2 1 chr17:3793472_C_T rs753513 cis 17 3793472 T C 0.3029 -0.1143 0.0153 6.94e-14 'Calcium/calmodulin-dependent protein kinase kinase 1 ENSG00000004660 'CAMKK1 intron_variant ENSG00000004660 ENSG00000004660 'CAMKK1 3 novel specific_protein -0.31656 0.066375 2.45357874070603e-06 yes CAMKK1 Olink CELL REGULATION(v.3701) CAMKK1 chr17 3860315 3894891 -1 84254 protein_coding 17:3890178 4713 494_2_3 SeqId_2436_49 'CXCL16, soluble chr17:4638484_C_T$SeqId_2436_49 1 chr17:4638484_C_T rs1876444 cis 17 4638484 T C 0.4442 -0.1815 0.0133 3.05e-42 'C-X-C motif chemokine 16 ENSG00000161921 'CXCL16 synonymous_variant 0.589504 rs1050998 ENSG00000161921 'CXCL16 missense_variant ENSG00000161921 ENSG00000161921 'CXCL16 3 known specific_protein CXCL16 chr17 4733533 4739928 -1 58191 protein_coding 17:4735189 4739 494_2_4 SeqId_7948_129 'GLTD2 chr17:4685228_A_G$SeqId_7948_129 1 chr17:4685228_A_G rs34460487 cis 17 4685228 A G 0.3521 0.2706 0.0136 1.76e-88 'Glycolipid transfer protein domain-containing protein 2 ENSG00000182327 'GLTPD2 intron_variant ENSG00000182327 ENSG00000182327 'GLTPD2 3 known unspecific_effect GLTPD2 chr17 4788964 4790589 1 388323 protein_coding 17:4781933 7031 494_3_1 SeqId_16616_137 'ENOB chr17:4856376_A_G$SeqId_16616_137 1 chr17:4856376_A_G rs238238 cis 17 4856376 A G 0.3069 0.3212 0.0129 6.41e-136 'Beta-enolase ENSG00000108515 'ENO3 missense_variant ENSG00000108515 ENSG00000108515 'ENO3 5 novel suggestive_specific_pathway ENO3 chr17 4948092 4957131 1 2027 protein_coding 17:4953081 4989 494_3_2 SeqId_4990_87 'GP1BA chr17:4840868_A_G$SeqId_4990_87 1 chr17:4840868_A_G rs1060431 cis 17 4840868 A G 0.0735 0.3197 0.0247 3.02e-38 'Platelet glycoprotein Ib alpha chain ENSG00000185245 'GP1BA 3_prime_UTR_variant 0.998338 rs6065 ENSG00000185245 'GP1BA missense_variant ENSG00000185245 ENSG00000185245 'GP1BA 3 known specific_protein GP1BA chr17 4932277 4935023 1 2811 protein_coding 17:4937573 5296 495_1_3 SeqId_5452_71 'ASGR1 chr17:7080316_C_T$SeqId_5452_71 1 chr17:7080316_C_T rs55714927 cis 17 7080316 T C 0.1872 -0.1676 0.0166 5.3e-24 'Asialoglycoprotein receptor 1 ENSG00000141505 'ASGR1 synonymous_variant ENSG00000141505 ENSG00000141505 'ASGR1 4 known unspecific_effect ASGR1 chr17 7173431 7179564 -1 432 protein_coding 17:7176997 2567 495_1_4 SeqId_19262_219 'ACADV chr17:7124768_C_T$SeqId_19262_219 1 chr17:7124768_C_T rs9646410 cis 17 7124768 T C 0.4017 0.1002 0.0129 8.42e-15 'Very long-chain specific acyl-CoA dehydrogenase, mitochondrial ENSG00000072778 'ACADVL intron_variant ENSG00000072778 ENSG00000072778 'ACADVL 3 known suggestive_specific_pathway ACADVL chr17 7217125 7225266 1 37 protein_coding 17:7221449 4324 495_1_5 SeqId_9772_153 'NLGN2 chr17:7307950_G_T$SeqId_9772_153 1 chr17:7307950_G_T rs114576150 cis 17 7307950 T G 0.9015 0.2355 0.0221 1.99e-26 'Neuroligin-2 ENSG00000169992 'NLGN2 upstream_gene_variant ENSG00000169992 ENSG00000169992 'NLGN2 3 known unspecific_effect NLGN2 chr17 7404874 7419860 1 57555 protein_coding 17:7404631 243 495_2_1 SeqId_5939_42 'TWEAK chr17:7452752_A_G$SeqId_5939_42 1 chr17:7452752_A_G rs80067372 cis 17 7452752 A G 0.2817 0.5467 0.014 1.52e-333 'Tumor necrosis factor ligand superfamily member 12 ENSG00000239697 'TNFSF12 intron_variant ENSG00000239697 ENSG00000239697 'TNFSF12 3 known suggestive_specific_pathway 0.3372 0.07071 2.46093418995258e-06 yes TWEAK Olink INFLAMMATION(v.3012) TNFSF12 chr17 7549058 7557890 1 8742 protein_coding 17:7549435 377 495_2_3 SeqId_18922_27 'CD68 chr17:7484812_A_G$SeqId_18922_27 1 chr17:7484812_A_G rs9901675 cis 17 7484812 A G 0.0512 -0.2105 0.0279 4.7e-14 'Macrosialin ENSG00000129226 'CD68 missense_variant ENSG00000129226 ENSG00000129226 'CD68 3 novel unspecific_effect CD68 chr17 7579491 7582111 1 968 protein_coding 17:7581494 2003 495_2_4 SeqId_12524_18 'SAT2 chr17:7526887_A_C$SeqId_12524_18 1 chr17:7526887_A_C rs858522 cis 17 7526887 A C 0.5721 -0.4588 0.0128 2.94e-282 'Diamine acetyltransferase 2 ENSG00000141504 'SAT2 downstream_gene_variant ENSG00000141504 ENSG00000141504 'SAT2 3 known suggestive_specific_pathway SAT2 chr17 7626234 7627876 -1 112483 protein_coding 17:7623569 4307 495_2_5 SeqId_4929_55 'SHBG chr17:7533423_A_G$SeqId_4929_55 1 chr17:7533423_A_G rs1799941 cis 17 7533423 A G 0.2582 0.1967 0.0135 4.31e-48 'Sex hormone-binding globulin ENSG00000129214 'SHBG upstream_gene_variant ENSG00000129214 ENSG00000129214 'SHBG 3 known suggestive_specific_pathway SHBG chr17 7613946 7633382 1 6462 protein_coding 17:7630105 16159 495_2_6 SeqId_7218_87 'AT1B2 chr17:7549681_C_T$SeqId_7218_87 1 chr17:7549681_C_T rs1641523 cis 17 7549681 T C 0.5671 -0.1825 0.0127 1.61e-46 'Sodium/potassium-transporting ATPase subunit beta-2 ENSG00000129244 'ATP1B2 upstream_gene_variant ENSG00000129244 ENSG00000129244 'ATP1B2 3 known suggestive_specific_pathway ATP1B2 chr17 7646627 7657770 1 482 protein_coding 17:7646363 264 495_2_7 SeqId_12422_143 'LX15B chr17:7961512_D_I$SeqId_12422_143 1 chr17:7961512_D_I rs35362199 cis 17 7961512 D I 0.3899 -0.2288 0.014 4.44e-60 'Arachidonate 15-lipoxygenase B ENSG00000179593 'ALOX15B upstream_gene_variant 0.219099 rs4792147 ENSG00000179593 'ALOX15B missense_variant ENSG00000179593 ENSG00000179593 'ALOX15B 3 known specific_protein ALOX15B chr17 8039034 8049134 1 247 protein_coding 17:8058195 19161 495_3_1 SeqId_6649_51 'NET1 chr17:8985510_G_T$SeqId_6649_51 1 chr17:8985510_G_T rs9897200 cis 17 8985510 T G 0.1119 -0.5778 0.0199 1.26e-184 'Netrin-1 ENSG00000065320 'NTN1 intron_variant ENSG00000065320 ENSG00000065320 'NTN1 3 known specific_protein NTN1 chr17 9021510 9244000 1 9423 protein_coding 17:9082193 60683 497_1_1 SeqId_6986_17 'HS3SB chr17:13835308_A_G$SeqId_6986_17 1 chr17:13835308_A_G rs62053877 cis 17 13835308 A G 0.3863 0.0977 0.0134 2.91e-13 'Heparan sulfate glucosamine 3-O-sulfotransferase 3B1 ENSG00000125430 'HS3ST3B1 downstream_gene_variant ENSG00000125430 ENSG00000125430 'HS3ST3B1 4 novel suggestive_specific_pathway HS3ST3B1 chr17 14301081 14349404 1 9953 protein_coding 17:13931991 369090 498_1_2 SeqId_17856_23 'NT5M chr17:17206672_C_G$SeqId_17856_23 1 chr17:17206672_C_G rs192436452 cis 17 17206672 C G 0.0459 0.5982 0.029 1.34e-94 '5'(3')-deoxyribonucleotidase, mitochondrial ENSG00000205309 'NT5M 5_prime_UTR_variant ENSG00000205309 ENSG00000205309 'NT5M 3 novel specific_protein NT5M chr17 17303335 17347663 1 56953 protein_coding 17:17303358 23 498_1_4 SeqId_12677_164 'FLII chr17:18165019_C_T$SeqId_12677_164 1 chr17:18165019_C_T rs138865936 cis 17 18165019 T C 0.029 0.5037 0.0384 3.14e-39 'Protein flightless-1 homolog ENSG00000177731 'FLII intron_variant 0.990064 rs145840264 ENSG00000177731 'FLII missense_variant ENSG00000177731 ENSG00000177731 'FLII 3 novel suggestive_specific_pathway FLII chr17 18244815 18258738 -1 2314 protein_coding 17:18261705 2967 498_1_5 SeqId_12334_25 'cSHMT chr17:18268999_A_G$SeqId_12334_25 1 chr17:18268999_A_G rs4398149 cis 17 18268999 A G 0.371 -0.8779 0.0103 2.95e-1580 'Serine hydroxymethyltransferase, cytosolic ENSG00000176974 'SHMT1 upstream_gene_variant 0.172639 rs1979277 ENSG00000176974 'SHMT1 missense_variant ENSG00000176974 ENSG00000176974 'SHMT1 3 known specific_protein SHMT1 chr17 18327860 18363563 -1 6470 protein_coding 17:18365685 2122 498_1_6 SeqId_19150_20 'KPRB chr17:18804385_C_T$SeqId_19150_20 1 chr17:18804385_C_T rs11078421 cis 17 18804385 T C 0.5401 -0.1376 0.0128 7.17e-27 'Phosphoribosyl pyrophosphate synthase-associated protein 2 ENSG00000141127 'PRPSAP2 intron_variant ENSG00000141127 ENSG00000141127 'PRPSAP2 3 novel specific_protein PRPSAP2 chr17 18840085 18931287 1 5636 protein_coding 17:18901072 60987 498_2_1 SeqId_5636_10 'MFAP4 chr17:19289286_C_G$SeqId_5636_10 1 chr17:19289286_C_G rs139356332 cis 17 19289286 C G 0.0213 -0.6813 0.0486 1.02e-44 'Microfibril-associated glycoprotein 4 ENSG00000166482 'MFAP4 intron_variant ENSG00000166482 ENSG00000166482 'MFAP4 3 novel specific_protein MFAP4 chr17 19383442 19387190 -1 4239 protein_coding 17:19385973 1217 498_2_2 SeqId_11480_1 'Aldehyde dehydrogenase, class 3 chr17:19645938_A_C$SeqId_11480_1 1 chr17:19645938_A_C rs887241 cis 17 19645938 A C 0.3462 -0.1897 0.0142 6.34e-41 'Aldehyde dehydrogenase, dimeric NADP-preferring ENSG00000108602 'ALDH3A1 missense_variant ENSG00000108602 ENSG00000108602 'ALDH3A1 3 known specific_protein -0.55633 0.060937 1.90546071796325e-18 yes ALDH3A1 Olink ORGAN DAMAGE(v.3301) ALDH3A1 chr17 19737984 19748943 -1 218 protein_coding 17:19742625 6318 5_1_1 SeqId_18173_11 'ARK73 chr1:19571849_C_T$SeqId_18173_11 1 chr1:19571849_C_T rs12095284 cis 1 19571849 T C 0.6284 0.2842 0.0136 4.93e-97 'Aflatoxin B1 aldehyde reductase member 3 ENSG00000162482 'AKR7A3 intron_variant 0.287555 rs2231198 ENSG00000162482 'AKR7A3 missense_variant ENSG00000162482 ENSG00000162482 'AKR7A3 3 novel specific_protein AKR7A3 chr1 19282573 19288770 -1 22977 protein_coding 1:19245355 43415 5_1_2 SeqId_4188_1 'Aflatoxin B1 aldehyde reductase chr1:19661156_C_T$SeqId_4188_1 1 chr1:19661156_C_T rs12122880 cis 1 19661156 T C 0.6553 0.2558 0.0134 1.12e-80 'Aflatoxin B1 aldehyde reductase member 2 ENSG00000053371 'AKR7A2 downstream_gene_variant ENSG00000053371 ENSG00000053371 'AKR7A2 3 novel specific_protein AKR7A2 chr1 19303965 19312144 -1 8574 protein_coding 1:19334662 22518 5_1_3 SeqId_2692_74 'NPS-PLA2 chr1:20306146_C_G$SeqId_2692_74 1 chr1:20306146_C_G rs11573156 cis 1 20306146 C G 0.2376 0.8338 0.0123 1.64e-1000 'Phospholipase A2, membrane associated ENSG00000188257 'PLA2G2A 5_prime_UTR_variant ENSG00000188257 ENSG00000188257 'PLA2G2A 3 known specific_protein PLA2G2A chr1 19975431 19980416 -1 5320 protein_coding 1:19979653 763 50_1_2 SeqId_8664_36 'PKDCC chr2:42285200_D_I$SeqId_8664_36 1 chr2:42285200_D_I rs534845187 cis 2 42285200 D I 0.9853 -0.5756 0.0602 1.19e-21 'Extracellular tyrosine-protein kinase PKDCC ENSG00000162878 'PKDCC 3_prime_UTR_variant 0.911857 rs34372645 ENSG00000162878 'PKDCC missense_variant ENSG00000162878 ENSG00000162878 'PKDCC 3 novel specific_protein PKDCC chr2 42048021 42058517 1 91461 protein_coding 2:42058061 10040 50_1_3 SeqId_2977_7 'EDAR chr2:43161180_A_G$SeqId_2977_7 1 chr2:43161180_A_G rs12712870 trans 2 43161180 A G 0.3151 -0.146 0.0142 5.94e-25 'Tumor necrosis factor receptor superfamily member EDAR ENSG00000135960 'EDAR intergenic_variant 0.110644 rs3816183 ENSG00000162882 'HAAO missense_variant none none ' novel unspecific_effect EDAR chr2 108894471 108989372 -1 10913 protein_coding 2:42934040 66055332 500_1_1 SeqId_5623_11 'CLM1 chr17:26694861_A_G$SeqId_5623_11 1 chr17:26694861_A_G rs704 trans 17 26694861 A G 0.4725 -0.1427 0.0136 9.3e-26 'CMRF35-like molecule 1 ENSG00000186074 'CD300LF missense_variant ENSG00000109072 ENSG00000109072 'VTN 7 known unspecific_effect -0.020735 0.064804 0.749134848165822 no CLM-1 Olink NEUROLOGY(v.8011) CD300LF chr17 74694311 74712978 -1 146722 protein_coding 17:28367840 46345138 500_1_1 SeqId_11281_6 'GRB7 chr17:26694861_A_G$SeqId_11281_6 1 chr17:26694861_A_G rs704 trans 17 26694861 A G 0.4726 0.142 0.0135 8.05e-26 'Growth factor receptor-bound protein 7 ENSG00000141738 'GRB7 missense_variant ENSG00000109072 ENSG00000109072 'VTN 7 known unspecific_effect GRB7 chr17 39737927 39747291 1 2886 protein_coding 17:28367840 11370087 500_1_1 SeqId_11315_148 'PPM1D chr17:26694861_A_G$SeqId_11315_148 1 chr17:26694861_A_G rs704 trans 17 26694861 A G 0.4725 -0.2593 0.0131 1.13e-87 'Protein phosphatase 1D ENSG00000170836 'PPM1D missense_variant ENSG00000109072 ENSG00000109072 'VTN 7 known unspecific_effect PPM1D chr17 60600193 60666280 1 8493 protein_coding 17:28367840 32232353 500_1_1 SeqId_12482_5 'BPTF chr17:26694861_A_G$SeqId_12482_5 1 chr17:26694861_A_G rs704 trans 17 26694861 A G 0.4725 0.0928 0.0136 7.9e-12 'Nucleosome-remodeling factor subunit BPTF ENSG00000171634 'BPTF missense_variant ENSG00000109072 ENSG00000109072 'VTN 7 known unspecific_effect BPTF chr17 67825503 67984378 1 2186 protein_coding 17:28367840 39457663 500_1_1 SeqId_12534_10 'CACO2 chr17:26694861_A_G$SeqId_12534_10 1 chr17:26694861_A_G rs704 trans 17 26694861 A G 0.4725 -0.2075 0.0133 1.07e-54 'Calcium-binding and coiled-coil domain-containing protein 2 ENSG00000136436 'CALCOCO2 missense_variant ENSG00000109072 ENSG00000109072 'VTN 7 known unspecific_effect CALCOCO2 chr17 48831018 48866522 1 10241 protein_coding 17:28367840 20463178 500_1_1 SeqId_13125_45 'Vitronectin chr17:26694861_A_G$SeqId_13125_45 1 chr17:26694861_A_G rs704 cis 17 26694861 A G 0.4727 1.2203 0.0068 3.53e-6996 'Vitronectin ENSG00000109072 'VTN,SEBOX missense_variant ENSG00000109072 ENSG00000109072 'VTN 7 known unspecific_effect VTN chr17 28367284 28373091 -1 7448 protein_coding 17:28367840 5251 500_1_1 SeqId_13468_5 'NEUL4 chr17:26694861_A_G$SeqId_13468_5 1 chr17:26694861_A_G rs704 trans 17 26694861 A G 0.4726 -0.0954 0.0134 9.41e-13 'Neuralized-like protein 4 ENSG00000215041 'NEURL4 missense_variant ENSG00000109072 ENSG00000109072 'VTN 7 known unspecific_effect NEURL4 chr17 7315628 7329393 -1 84461 protein_coding 17:28367840 21038447 500_1_1 SeqId_13502_2 'S2611 chr17:26694861_A_G$SeqId_13502_2 1 chr17:26694861_A_G rs704 trans 17 26694861 A G 0.4726 -0.1317 0.0134 6.96e-23 'Sodium-independent sulfate anion transporter ENSG00000181045 'SLC26A11 missense_variant ENSG00000109072 ENSG00000109072 'VTN 7 known unspecific_effect SLC26A11 chr17 80219699 80253500 1 284129 protein_coding 17:28367840 51851859 500_1_1 SeqId_13530_5 'UR2R chr17:26694861_A_G$SeqId_13530_5 1 chr17:26694861_A_G rs704 trans 17 26694861 A G 0.4725 -0.1119 0.0135 1.42e-16 'Urotensin-2 receptor ENSG00000181408 'UTS2R missense_variant ENSG00000109072 ENSG00000109072 'VTN 7 known unspecific_effect UTS2R chr17 82371765 82377458 1 2837 protein_coding 17:28367840 54003925 500_1_1 SeqId_15333_11 'SDF2 chr17:26694861_A_G$SeqId_15333_11 1 chr17:26694861_A_G rs704 cis 17 26694861 A G 0.4725 0.3094 0.0133 8.08e-120 'Stromal cell-derived factor 2 ENSG00000132581 'SDF2 missense_variant ENSG00000132581 ENSG00000109072 'VTN 7 known unspecific_effect SDF2 chr17 28648346 28662189 -1 6388 protein_coding 17:28367840 294349 500_1_1 SeqId_16292_288 'GIP chr17:26694861_A_G$SeqId_16292_288 1 chr17:26694861_A_G rs704 trans 17 26694861 A G 0.4725 0.1127 0.0135 6.51e-17 'Gastric inhibitory polypeptide ENSG00000159224 'GIP missense_variant ENSG00000109072 ENSG00000109072 'VTN 7 known unspecific_effect GIP chr17 48958554 48968596 -1 2695 protein_coding 17:28367840 20600756 500_1_1 SeqId_17804_102 'PNPO chr17:26694861_A_G$SeqId_17804_102 1 chr17:26694861_A_G rs704 trans 17 26694861 A G 0.4726 0.122 0.0125 1.18e-22 'Pyridoxine-5'-phosphate oxidase ENSG00000108439 'PNPO missense_variant ENSG00000109072 ENSG00000109072 'VTN 7 known unspecific_effect PNPO chr17 47941506 47949308 1 55163 protein_coding 17:28367840 19573666 500_1_1 SeqId_19335_2 'HN1 chr17:26694861_A_G$SeqId_19335_2 1 chr17:26694861_A_G rs704 trans 17 26694861 A G 0.4725 -0.4263 0.013 5.31e-237 'Hematological and neurological expressed 1 protein ENSG00000189159 'HN1 missense_variant ENSG00000109072 ENSG00000109072 'VTN 7 known unspecific_effect JPT1 chr17 75135248 75168281 -1 51155 protein_coding 17:28367840 46800441 500_1_1 SeqId_19356_20 'TM1L2 chr17:26694861_A_G$SeqId_19356_20 1 chr17:26694861_A_G rs704 trans 17 26694861 A G 0.4726 0.0961 0.0134 8.91e-13 'TOM1-like protein 2 ENSG00000175662 'TOM1L2 missense_variant ENSG00000109072 ENSG00000109072 'VTN 7 known unspecific_effect TOM1L2 chr17 17843511 17972422 -1 146691 protein_coding 17:28367840 10395418 500_1_1 SeqId_7785_1 'Ephrin-B3 chr17:26694861_A_G$SeqId_7785_1 1 chr17:26694861_A_G rs704 trans 17 26694861 A G 0.4726 0.1592 0.0134 1.84e-32 'Ephrin-B3 ENSG00000108947 'EFNB3 missense_variant ENSG00000109072 ENSG00000109072 'VTN 7 known unspecific_effect EFNB3 chr17 7705202 7711372 1 1949 protein_coding 17:28367840 20662638 500_1_1 SeqId_3034_1 'GFAP chr17:26694861_A_G$SeqId_3034_1 1 chr17:26694861_A_G rs704 trans 17 26694861 A G 0.4725 -0.0948 0.0135 1.99e-12 'Glial fibrillary acidic protein ENSG00000131095 'GFAP missense_variant ENSG00000109072 ENSG00000109072 'VTN 7 known unspecific_effect GFAP chr17 44903159 44916937 -1 2670 protein_coding 17:28367840 16549097 500_1_1 SeqId_6571_75 'CQ078 chr17:26694861_A_G$SeqId_6571_75 1 chr17:26694861_A_G rs704 trans 17 26694861 A G 0.4727 -0.0974 0.0128 2.47e-14 'Uncharacterized protein C17orf78 ENSG00000167230 'C17orf78 missense_variant ENSG00000109072 ENSG00000109072 'VTN 7 known unspecific_effect C17orf78 chr17 37375985 37392708 1 284099 protein_coding 17:28367840 9008145 500_1_1 SeqId_8076_4 'SACA3 chr17:26694861_A_G$SeqId_8076_4 1 chr17:26694861_A_G rs704 trans 17 26694861 A G 0.4725 -0.0984 0.0137 6.03e-13 'Sperm acrosome membrane-associated protein 3 ENSG00000141316 'SPACA3 missense_variant ENSG00000109072 ENSG00000109072 'VTN 7 known unspecific_effect SPACA3 chr17 32970376 32997877 1 124912 protein_coding 17:28367840 4602536 500_1_3 SeqId_9197_4 'LEG9 chr17:25971978_A_G$SeqId_9197_4 1 chr17:25971978_A_G rs74321993 cis 17 25971978 A G 0.2451 -0.1903 0.0153 2.39e-35 'Galectin-9 ENSG00000168961 'LGALS9 intron_variant 0.987086 rs361497 ENSG00000168961 'LGALS9 missense_variant ENSG00000168961 ENSG00000168961 'LGALS9 3 known suggestive_specific_pathway LGALS9 chr17 27629798 27649560 1 3965 protein_coding 17:27644952 15154 500_1_4 SeqId_9876_20 'aldolase C chr17:26991821_C_T$SeqId_9876_20 1 chr17:26991821_C_T rs56147019 cis 17 26991821 T C 0.0171 -0.5652 0.0573 5.87e-23 'Fructose-bisphosphate aldolase C ENSG00000109107 'ALDOC intron_variant ENSG00000109107 ENSG00000109107 'ALDOC 3 novel unspecific_effect ALDOC chr17 28573115 28576948 -1 230 protein_coding 17:28664803 87855 500_2_3 SeqId_16908_5 'OMGP chr17:29616516_G_T$SeqId_16908_5 1 chr17:29616516_G_T rs72815624 cis 17 29616516 T G 0.1353 -0.1355 0.0193 2.4e-12 'Oligodendrocyte-myelin glycoprotein ENSG00000126861 'OMG intron_variant 0.994371 rs11080149 ENSG00000126861 'OMG missense_variant ENSG00000126861 ENSG00000126861 'OMG 3 novel unspecific_effect OMG chr17 31272013 31297539 -1 4974 protein_coding 17:31289498 8041 501_1_1 SeqId_13748_4 'MCP-2 chr17:32647831_A_C$SeqId_13748_4 1 chr17:32647831_A_C rs1133763 cis 17 32647831 A C 0.8367 1.2391 0.014 8.49e-1704 'C-C motif chemokine 8 ENSG00000108700 'CCL8 missense_variant ENSG00000108700 ENSG00000108688|ENSG00000108700 'CCL7|CCL8 3 known suggestive_specific_pathway 1.1471 0.066764 6.12350391724772e-52 yes MCP-2 Olink INFLAMMATION(v.3012) CCL8 chr17 34319435 34321402 1 6355 protein_coding 17:34320812 1377 501_1_1 SeqId_4886_3 'MCP-3 chr17:32647831_A_C$SeqId_4886_3 1 chr17:32647831_A_C rs1133763 cis 17 32647831 A C 0.8367 0.9129 0.0159 2.08e-718 'C-C motif chemokine 7 ENSG00000108688 'CCL7 missense_variant ENSG00000108688 ENSG00000108688|ENSG00000108700 'CCL7|CCL8 3 known suggestive_specific_pathway 0.03779 0.0838 0.65222884246564 no MCP-3 Olink INFLAMMATION(v.3012) CCL7 chr17 34270221 34272242 1 6354 protein_coding 17:34320812 50591 501_1_2 SeqId_5301_7 'Eotaxin chr17:32519101_A_T$SeqId_5301_7 1 chr17:32519101_A_T rs9903369 cis 17 32519101 A T 0.5777 0.1174 0.0132 6.08e-19 'Eotaxin ENSG00000172156 'CCL11 intron_variant 0.252736 rs1129844 ENSG00000172156 'CCL11 missense_variant ENSG00000172156 ENSG00000172156 'CCL11 3 known specific_protein CCL11 chr17 34285742 34288334 1 6356 protein_coding 17:34192082 93660 501_2_1 SeqId_6372_7 'YBOX2 chr17:33884804_C_T$SeqId_6372_7 1 chr17:33884804_C_T rs10512472 trans 17 33884804 T C 0.8258 -0.2125 0.0166 1.59e-37 'Y-box-binding protein 2 ENSG00000006047 'YBX2 missense_variant ENSG00000236320 ENSG00000236320 'SLFN14 3 novel unspecific_effect YBX2 chr17 7288263 7294639 -1 51087 protein_coding 17:35557785 28263146 501_2_2 SeqId_5480_49 'RANTES chr17:34212128_C_T$SeqId_5480_49 1 chr17:34212128_C_T rs7211393 cis 17 34212128 T C 0.1831 -0.275 0.0158 1.52e-67 'C-C motif chemokine 5 ENSG00000161570 'CCL5 upstream_gene_variant ENSG00000161570 ENSG00000161570 ' 3 known suggestive_specific_pathway -0.17899 0.08413 0.0338766143370822 yes CCL5 Olink CARDIOMETABOLIC(v.3602) CCL5 chr17 35871491 35880793 -1 6352 protein_coding 17:35885124 4331 501_2_3 SeqId_4913_78 'HCC-4 chr17:34306106_A_G$SeqId_4913_78 1 chr17:34306106_A_G rs10445391 cis 17 34306106 A G 0.9052 1.4494 0.0173 6.17e-1527 'C-C motif chemokine 16 ENSG00000161573 'CCL16 intron_variant 0.222019 rs79254649 ENSG00000161573 'CCL16 missense_variant ENSG00000161573 ENSG00000161573 ' 3 known unspecific_effect 1.2375 0.098068 9.39723310564636e-32 yes CCL16 Olink CARDIOVASCULAR III(v.6112) CCL16 chr17 35976493 35981497 -1 6360 protein_coding 17:35979070 2427 501_2_4 SeqId_3044_3 'PARC chr17:34391617_A_G$SeqId_3044_3 1 chr17:34391617_A_G rs2015086 cis 17 34391617 A G 0.8605 -0.9178 0.017 1.75e-635 'C-C motif chemokine 18 ENSG00000006074 'CCL18 upstream_gene_variant ENSG00000006074 ENSG00000006074|ENSG00000006075 ' 3 known suggestive_specific_pathway -0.72009 0.08085 1.06659612123025e-17 yes CCL18 Olink CARDIOMETABOLIC(v.3602) CCL18 chr17 36064272 36072032 1 6362 protein_coding 17:36064257 15 501_2_4 SeqId_3040_59 'MIP-1a chr17:34391617_A_G$SeqId_3040_59 1 chr17:34391617_A_G rs2015086 cis 17 34391617 A G 0.8605 -0.6983 0.0184 1.56e-314 'C-C motif chemokine 3 ENSG00000006075 'CCL3 upstream_gene_variant ENSG00000006075 ENSG00000006074|ENSG00000006075 ' 3 known suggestive_specific_pathway 0.15455 0.089525 0.0849180475036314 no CCL3 Olink CARDIOVASCULAR II(v.5004) CCL3 chr17 36088256 36090169 -1 6348 protein_coding 17:36064257 25912 501_2_5 SeqId_3028_36 'Ck-b-8-1 chr17:34326215_A_C$SeqId_3028_36 1 chr17:34326215_A_C rs712048 cis 17 34326215 A C 0.1342 -0.7023 0.0182 9.49e-326 'Ck-beta-8-1 ENSG00000167236 'CCL23 intron_variant 0.609828 rs1003645 ENSG00000167236 'CCL23 missense_variant ENSG00000167236 ENSG00000167236 ' 3 known suggestive_specific_pathway -0.58225 0.086187 4.1209751909733e-11 yes CCL23 Olink INFLAMMATION(v.3012) CCL23 chr17 36013056 36017972 -1 6368 protein_coding 17:35999179 18793 501_2_5 SeqId_2913_1 'MPIF-1 chr17:34326215_A_C$SeqId_2913_1 1 chr17:34326215_A_C rs712048 cis 17 34326215 A C 0.1342 -0.5846 0.0193 5.72e-202 'C-C motif chemokine 23 ENSG00000167236 'CCL23 intron_variant 0.609828 rs1003645 ENSG00000167236 'CCL23 missense_variant ENSG00000167236 ENSG00000167236 ' 3 known suggestive_specific_pathway -0.58225 0.086187 4.1209751909733e-11 yes CCL23 Olink INFLAMMATION(v.3012) CCL23 chr17 36013056 36017972 -1 6368 protein_coding 17:35999179 18793 501_2_8 SeqId_18289_16 'MIP-5 chr17:34329822_A_C$SeqId_18289_16 1 chr17:34329822_A_C rs854628 cis 17 34329822 A C 0.9254 -1.6552 0.0204 2.87e-1432 'C-C motif chemokine 15 ENSG00000267596 'CCL15 upstream_gene_variant 0.50618 rs854625 ENSG00000267596 'CCL15 missense_variant ENSG00000267596 ENSG00000267596 ' 3 known suggestive_specific_pathway -1.5993 0.10777 2.57632115700258e-41 yes CCL15 Olink CARDIOVASCULAR III(v.6112) CCL15 chr17 35996440 36001553 -1 6359 protein_coding 17:36002776 1223 501_2_9 SeqId_2900_53 'HCC-1 chr17:34335694_C_T$SeqId_2900_53 1 chr17:34335694_C_T rs7222922 cis 17 34335694 T C 0.1186 -1.0537 0.0178 1.56e-763 'C-C motif chemokine 14 ENSG00000213494 'CCL14 downstream_gene_variant 0.364472 rs16971802 ENSG00000213494 'CCL14 missense_variant ENSG00000213494 ENSG00000213494 ' 3 known specific_pathway -0.33147 0.092356 0.000365763193009452 yes CCL14 Olink CARDIOMETABOLIC(v.3602) CCL14 chr17 35983288 35987004 -1 6358 protein_coding 17:36008654 21650 501_3_1 SeqId_2781_63 'LAG-1 chr17:34819750_A_G$SeqId_2781_63 1 chr17:34819750_A_G rs8064426 cis 17 34819750 A G 0.1297 -0.3122 0.0215 1.22e-47 'C-C motif chemokine 4-like ENSG00000197262|ENSG00000205020 'CCL4L2|CCL4L1 regulatory_region_variant ENSG00000197262|ENSG00000205020 ENSG00000129277|ENSG00000197262|ENSG00000205020 ' 3 known suggestive_specific_pathway CCL4L2 chr17 36210924 36212878 1 9560 protein_coding 17:36463908 252984 503_1_1 SeqId_19135_5 'Cytosolic 5'-nucleotidase III-like protein chr17:39982432_A_C$SeqId_19135_5 1 chr17:39982432_A_C 17:39982432_A_C cis 17 39982432 A C 0.2547 0.9008 0.0125 2.24e-1130 '7-methylguanosine phosphate-specific 5'-nucleotidase ENSG00000141698 'NT5C3B intron_variant 0.998532 rs1046404 ENSG00000141698 'NT5C3B missense_variant ENSG00000141698 ENSG00000141698 'NT5C3B 3 known suggestive_specific_pathway NT5C3B chr17 41825057 41836260 -1 115024 protein_coding 17:41826180 10080 503_1_2 SeqId_6609_22 'CN37 chr17:40123521_A_G$SeqId_6609_22 1 chr17:40123521_A_G rs11079027 cis 17 40123521 A G 0.2628 -0.1055 0.0146 5.87e-13 '2',3'-cyclic-nucleotide 3'-phosphodiesterase ENSG00000173786 'CNP intron_variant ENSG00000173786 ENSG00000173786 'CNP 3 known suggestive_specific_pathway CNP chr17 41966763 41977740 1 1267 protein_coding 17:41971503 4740 503_1_3 SeqId_14012_17 'LGP2 chr17:40270119_D_I$SeqId_14012_17 1 chr17:40270119_D_I rs544381672 cis 17 40270119 D I 0.1816 -0.5561 0.0166 1.26e-244 'Probable ATP-dependent RNA helicase DHX58 ENSG00000108771 'DHX58 intron_variant 0.948626 rs2074158 ENSG00000108771 'DHX58 missense_variant ENSG00000108771 ENSG00000108771 'DHX58 3 novel suggestive_specific_pathway DHX58 chr17 42101404 42112714 -1 79132 protein_coding 17:42118102 5388 503_1_4 SeqId_10346_5 'STAT3 chr17:40499198_A_G$SeqId_10346_5 1 chr17:40499198_A_G rs35950888 cis 17 40499198 A G 0.6494 0.2649 0.013 1.28e-91 'Signal transducer and activator of transcription 3 ENSG00000168610 'STAT3 intron_variant ENSG00000168610 ENSG00000168610 'STAT3 3 known suggestive_specific_pathway STAT3 chr17 42313324 42388540 -1 6774 protein_coding 17:42347180 41360 503_1_5 SeqId_15509_2 'NAG chr17:40622538_A_G$SeqId_15509_2 1 chr17:40622538_A_G rs77942990 cis 17 40622538 A G 0.0406 1.3027 0.0309 2.14e-388 'Alpha-N-acetylglucosaminidase ENSG00000108784 'NAGLU intron_variant 0.742597 rs86312_C_G ENSG00000108784 'NAGLU missense_variant ENSG00000108784 ENSG00000108784 'NAGLU 3 novel unspecific_effect NAGLU chr17 42536241 42544449 1 4669 protein_coding 17:42470520 65721 503_1_7 SeqId_10499_1 'T106A chr17:41226675_A_T$SeqId_10499_1 1 chr17:41226675_A_T rs2236762 cis 17 41226675 A T 0.6619 0.1258 0.0138 6.94e-20 'Transmembrane protein 106A ENSG00000184988 'TMEM106A intron_variant ENSG00000184988 ENSG00000184988 'TMEM106A 3 known unspecific_effect TMEM106A chr17 43211835 43220041 1 113277 protein_coding 17:43074658 137177 503_2_1 SeqId_4992_49 'GRN chr17:42430244_C_T$SeqId_4992_49 1 chr17:42430244_C_T rs5848 cis 17 42430244 T C 0.2788 -0.2453 0.015 6.6e-60 'Granulins ENSG00000030582 'GRN 3_prime_UTR_variant 0.637031 rs5911 ENSG00000005961 'ITGA2B missense_variant ENSG00000030582 ENSG00000030582 'GRN 5 known suggestive_specific_pathway -0.1203 0.069336 0.0833681184619634 no GRN Olink CARDIOVASCULAR III(v.6112) GRN chr17 44345246 44353106 1 2896 protein_coding 17:44352876 7630 503_2_1 SeqId_6304_8 'C1QT1 chr17:42430244_C_T$SeqId_6304_8 1 chr17:42430244_C_T rs5848 trans 17 42430244 T C 0.2787 -0.2473 0.0152 2.93e-59 'Complement C1q tumor necrosis factor-related protein 1 ENSG00000173918 'C1QTNF1 3_prime_UTR_variant 0.637031 rs5911 ENSG00000005961 'ITGA2B missense_variant ENSG00000030582 ENSG00000030582 'GRN 5 known suggestive_specific_pathway C1QTNF1 chr17 79022814 79049788 1 114897 protein_coding 17:44352876 34669938 503_2_2 SeqId_6404_20 'C1QRF chr17:43037191_C_G$SeqId_6404_20 1 chr17:43037191_C_G rs1055646 cis 17 43037191 C G 0.5223 -0.2117 0.0122 6.46e-68 'C1q-related factor ENSG00000131094 'C1QL1 3_prime_UTR_variant ENSG00000131094 ENSG00000131094 'C1QL1 3 known specific_protein C1QL1 chr17 44959693 44968303 -1 10882 protein_coding 17:44959823 8480 503_3_1 SeqId_15596_7 'HEXI1 chr17:43223292_A_G$SeqId_15596_7 1 chr17:43223292_A_G rs9894577 cis 17 43223292 A G 0.3155 0.1464 0.0133 3.6e-28 'Protein HEXIM1 ENSG00000186834 'HEXIM1 upstream_gene_variant ENSG00000186834 ENSG00000168517|ENSG00000186834 'HEXIM1|HEXIM2 3 novel suggestive_specific_pathway 0.12719 0.068079 0.0623304123501945 no HEXIM1 Olink IMMUNE RESPONSE(v.3202) HEXIM1 chr17 45148475 45152099 1 10614 protein_coding 17:45145925 2550 503_3_1 SeqId_14205_6 'HEXI2 chr17:43223316_D_I$SeqId_14205_6 1 chr17:43223316_D_I rs112981250 cis 17 43223316 D I 0.6845 -0.1283 0.0132 3.18e-22 'Protein HEXIM2 ENSG00000168517 'HEXIM2 upstream_gene_variant ENSG00000168517 ENSG00000168517|ENSG00000186834 'HEXIM1|HEXIM2 3 novel suggestive_specific_pathway HEXIM2 chr17 45160700 45170040 1 124790 protein_coding 17:45145950 14750 503_3_4 SeqId_13992_12 'NSF chr17:44265839_C_T$SeqId_13992_12 1 chr17:44265839_C_T rs2532240 cis 17 44265839 T C 0.4242 0.1061 0.0124 1.39e-17 'Vesicle-fusing ATPase ENSG00000073969 'NSF intron_variant ENSG00000073969 ENSG00000073969 'NSF 3 novel specific_protein NSF chr17 46590669 46757464 1 4905 protein_coding 17:46188473 402196 504_1_1 SeqId_12534_10 'CACO2 chr17:46926615_A_G$SeqId_12534_10 1 chr17:46926615_A_G rs550510 cis 17 46926615 A G 0.146 -0.157 0.0188 7.92e-17 'Calcium-binding and coiled-coil domain-containing protein 2 ENSG00000136436 'CALCOCO2 missense_variant,splice_region_variant ENSG00000136436 ENSG00000136436 'CALCOCO2 3 known specific_protein CALCOCO2 chr17 48831018 48866522 1 10241 protein_coding 17:48849253 18235 505_1_1 SeqId_3235_50 'WFKN2 chr17:48907834_C_T$SeqId_3235_50 1 chr17:48907834_C_T rs11079936 cis 17 48907834 T C 0.3417 0.5176 0.0131 2.02e-341 'WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2 ENSG00000173714 'WFIKKN2 upstream_gene_variant ENSG00000173714 ENSG00000173714 'WFIKKN2 7 known specific_pathway 0.58801 0.061342 4.83058802039774e-20 yes WFIKKN2 Olink DEVELOPMENT(v.3511) WFIKKN2 chr17 50834650 50842353 1 124857 protein_coding 17:50830473 4177 505_1_2 SeqId_12651_21 'PDK2 chr17:48172095_A_C$SeqId_12651_21 1 chr17:48172095_A_C rs111564639 cis 17 48172095 A C 0.0278 -0.4426 0.0414 1.04e-26 '[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial ENSG00000005882 'PDK2 upstream_gene_variant ENSG00000005882 ENSG00000005882 'PDK2 3 novel specific_protein PDK2 chr17 50094737 50112152 1 5164 protein_coding 17:50094731 6 505_1_3 SeqId_13460_4 'CHAD chr17:48508221_A_C$SeqId_13460_4 1 chr17:48508221_A_C rs184613584 cis 17 48508221 A C 0.99 0.5522 0.0703 4.16e-15 'Chondroadherin ENSG00000136457 'CHAD intron_variant 0.510151 rs144030994 ENSG00000136457 'CHAD missense_variant ENSG00000136457 ENSG00000136457 'CHAD 3 novel specific_protein CHAD chr17 50464496 50468906 -1 1101 protein_coding 17:50430860 38046 505_1_5 SeqId_11117_2 'SPT20 chr17:48625928_C_G$SeqId_11117_2 1 chr17:48625928_C_G rs8076632 cis 17 48625928 C G 0.6357 0.7826 0.012 3.26e-926 'Spermatogenesis-associated protein 20 ENSG00000006282 'SPATA20 missense_variant ENSG00000006282 ENSG00000006282 'SPATA20 3 known specific_protein SPATA20 chr17 50543058 50555852 1 64847 protein_coding 17:50548567 5509 505_2_1 SeqId_13666_222 'Carbonic Anhydrase X chr17:50213731_A_G$SeqId_13666_222 1 chr17:50213731_A_G rs117399000 cis 17 50213731 A G 0.0311 -0.616 0.0378 1.22e-59 'Carbonic anhydrase-related protein 10 ENSG00000154975 'CA10 intron_variant ENSG00000154975 ENSG00000154975 'CA10 3 known specific_protein CA10 chr17 51630313 52160017 -1 56934 protein_coding 17:52136371 23646 506_1_1 SeqId_8778_3 'Noggin chr17:54840864_A_G$SeqId_8778_3 1 chr17:54840864_A_G rs76164057 cis 17 54840864 A G 0.9869 -1.6721 0.0601 3.1e-170 'Noggin ENSG00000183691 'NOG regulatory_region_variant ENSG00000183691 ENSG00000183691 'NOG 3 known specific_protein NOG chr17 56593699 56595611 1 9241 protein_coding 17:56763503 169804 507_1_1 SeqId_2580_83 'Myeloperoxidase chr17:56358429_C_T$SeqId_2580_83 1 chr17:56358429_C_T rs34097845 cis 17 56358429 T C 0.054 -0.5839 0.0316 2.76e-76 'Myeloperoxidase ENSG00000005381 'MPO upstream_gene_variant 0.363419 rs28730837 ENSG00000005381 'MPO missense_variant ENSG00000005381 ENSG00000005381 'MPO 6 known suggestive_specific_pathway -0.32138 0.15165 0.0345780103532306 yes MPO Olink CARDIOVASCULAR III(v.6112) MPO chr17 58269855 58280935 -1 4353 protein_coding 17:58281068 133 507_1_1 SeqId_2860_19 'Karyopherin-a2 chr17:56358429_C_T$SeqId_2860_19 1 chr17:56358429_C_T rs34097845 trans 17 56358429 T C 0.0539 -0.3691 0.0305 9.73e-34 'Importin subunit alpha-1 ENSG00000182481 'KPNA2 upstream_gene_variant 0.363419 rs28730837 ENSG00000005381 'MPO missense_variant ENSG00000011143|ENSG00000108384|ENSG00000108389|ENSG00000136450|ENSG00000213246|ENSG00000264364 ENSG00000005381 'MPO 6 known suggestive_specific_pathway KPNA2 chr17 68035636 68047364 1 3838 protein_coding 17:58281068 9754568 507_1_4 SeqId_4801_13 'PERL chr17:56320158_A_C$SeqId_4801_13 1 chr17:56320158_A_C rs8178290 cis 17 56320158 A C 0.2183 -0.2661 0.016 4.01e-62 'Lactoperoxidase ENSG00000167419 'LPO intron_variant ENSG00000167419 ENSG00000167419 'LPO 3 known unspecific_effect LPO chr17 58218548 58268518 1 4025 protein_coding 17:58242797 24249 507_1_5 SeqId_12554_10 'RA51D chr17:56759623_D_I$SeqId_12554_10 1 chr17:56759623_D_I rs36042986 trans 17 56759623 D I 0.8115 -0.1162 0.0164 1.56e-12 'DNA repair protein RAD51 homolog 4 ENSG00000185379 'RAD51D intron_variant 0.869279 rs17822735 ENSG00000181013 'C17orf47 missense_variant ENSG00000181013|ENSG00000108384 ENSG00000108384|ENSG00000181013 'RAD51C 2 novel specific_protein RAD51D chr17 35092221 35121522 -1 5892 protein_coding 17:58682263 23560741 508_1_1 SeqId_3041_55 'MRC2 chr17:60637258_A_C$SeqId_3041_55 1 chr17:60637258_A_C rs146385050 cis 17 60637258 A C 0.1835 -0.2599 0.0176 2.14e-49 'C-type mannose receptor 2 ENSG00000011028 'MRC2 intron_variant ENSG00000011028 ENSG00000011028 'MRC2 4 known suggestive_specific_pathway -0.097258 0.081308 0.232220202801473 no MRC2 Olink CELL REGULATION(v.3701) MRC2 chr17 62627670 62693597 1 9902 protein_coding 17:62559897 67773 508_1_1 SeqId_11140_56 'CO1A1 chr17:60637258_A_C$SeqId_11140_56 1 chr17:60637258_A_C rs146385050 trans 17 60637258 A C 0.1836 0.2833 0.0175 9.54e-59 'Collagen alpha-1(I) chain ENSG00000108821 'COL1A1 intron_variant ENSG00000146872|ENSG00000159640|ENSG00000253506|ENSG00000011028|ENSG00000274565|ENSG00000279713 ENSG00000011028 'MRC2 4 known suggestive_specific_pathway COL1A1 chr17 50184101 50201632 -1 1277 protein_coding 17:62559897 12358265 508_2_1 SeqId_10714_7 'ACE chr17:61570422_A_G$SeqId_10714_7 1 chr17:61570422_A_G rs4353 cis 17 61570422 A G 0.5293 0.6965 0.0119 1.80e-746 'Angiotensin-converting enzyme ENSG00000159640 'ACE intron_variant ENSG00000159640 ENSG00000159640 'ACE 3 known specific_protein ACE chr17 63477061 63498380 1 1636 protein_coding 17:63493061 16000 508_2_2 SeqId_11229_16 'ERN1 chr17:62181308_A_C$SeqId_11229_16 1 chr17:62181308_A_C rs8076809 cis 17 62181308 A C 0.7474 0.1324 0.0149 7.46e-19 'Serine/threonine-protein kinase/endoribonuclease IRE1 ENSG00000178607 'ERN1 intron_variant ENSG00000178607 ENSG00000178607 'ERN1 3 novel specific_protein ERN1 chr17 64039080 64130819 -1 2081 protein_coding 17:64103948 26871 509_1_1 SeqId_8288_27 'b2-Glycoprotein I chr17:64210580_A_C$SeqId_8288_27 1 chr17:64210580_A_C rs1801689 cis 17 64210580 A C 0.9708 1.6559 0.0376 1.25e-423 'Beta-2-glycoprotein 1 ENSG00000091583 'APOH missense_variant ENSG00000091583 ENSG00000091583 'APOH 7 known unspecific_effect APOH chr17 66212033 66256525 -1 350 protein_coding 17:66214462 42063 509_1_2 SeqId_10713_151 'CLM7 chr17:64250605_A_G$SeqId_10713_151 1 chr17:64250605_A_G rs13341435 trans 17 64250605 A G 0.0507 -0.2218 0.0305 3.39e-13 'CMRF35-like molecule 7 ENSG00000178789 'CD300LB intron_variant 0.820783 rs1801690 ENSG00000091583 'APOH missense_variant ENSG00000091583 ENSG00000091583 'APOH 4 known unspecific_effect CD300LB chr17 74521174 74531475 -1 124599 protein_coding 17:66254487 8276988 509_1_3 SeqId_11601_26 'DHX8 chr17:64215845_A_G$SeqId_11601_26 1 chr17:64215845_A_G rs7212477 trans 17 64215845 A G 0.693 0.7545 0.0123 1.09e-819 'ATP-dependent RNA helicase DHX8 ENSG00000067596 'DHX8 intron_variant 0.709653 rs4581 ENSG00000091583 'APOH missense_variant none ENSG00000091583 'APOH 3 known unspecific_effect DHX8 chr17 43483865 43610338 1 1659 protein_coding 17:66219727 22735862 509_1_5 SeqId_2644_11 'PKC-A chr17:64295082_D_I$SeqId_2644_11 1 chr17:64295082_D_I rs35180366 cis 17 64295082 D I 0.3919 0.1027 0.0133 1.38e-14 'Protein kinase C alpha type ENSG00000154229 'PRKCA upstream_gene_variant ENSG00000154229 ENSG00000154229 'PRKCA 3 novel unspecific_effect PRKCA chr17 66302613 66810743 1 5578 protein_coding 17:66298965 3648 51_1_2 SeqId_12812_25 'ACYP2 chr2:54356797_A_T$SeqId_12812_25 1 chr2:54356797_A_T rs7559380 cis 2 54356797 A T 0.5393 0.3606 0.0121 7.73e-194 'Acylphosphatase-2 ENSG00000170634 'ACYP2 intron_variant 0.124999 rs1363061 ENSG00000170634 'ACYP2 stop_gained ENSG00000170634 ENSG00000170634 'ACYP2 3 known specific_protein ACYP2 chr2 53970838 54305300 1 98 protein_coding 2:54129660 158822 51_2_2 SeqId_8480_29 'FBLN3 chr2:56096892_A_G$SeqId_8480_29 1 chr2:56096892_A_G rs3791679 cis 2 56096892 A G 0.7659 -0.2633 0.0152 6.31e-67 'EGF-containing fibulin-like extracellular matrix protein 1 ENSG00000115380 'EFEMP1 intron_variant ENSG00000115380 ENSG00000115380 'EFEMP1 3 known specific_protein -0.15411 0.065145 0.0183907736832808 yes EFEMP1 Olink CARDIOMETABOLIC(v.3602) EFEMP1 chr2 55865967 55924139 -1 2202 protein_coding 2:55869757 54382 510_1_4 SeqId_6433_57 'FA20A chr17:66623113_C_T$SeqId_6433_57 1 chr17:66623113_C_T rs77594545 cis 17 66623113 T C 0.9331 0.2339 0.0252 1.89e-20 'Pseudokinase FAM20A ENSG00000108950 'FAM20A upstream_gene_variant ENSG00000108950 ENSG00000108950 'FAM20A 3 known specific_protein FAM20A chr17 68535113 68601367 -1 54757 protein_coding 17:68626972 25605 512_1_1 SeqId_5066_134 'CLM6 chr17:72459776_A_G$SeqId_5066_134 1 chr17:72459776_A_G rs62087200 cis 17 72459776 A G 0.0494 -0.7811 0.0311 2.13e-139 'CMRF35-like molecule 6 ENSG00000167850 'CD300C upstream_gene_variant ENSG00000167850 ENSG00000167850 'CD300C 3 known specific_pathway 0.095538 0.14791 0.518632824509166 no CLM-6 Olink NEUROLOGY(v.8011) CD300C chr17 74541073 74546115 -1 10871 protein_coding 17:74463637 82478 512_1_2 SeqId_5630_48 'CM35H chr17:72469966_A_G$SeqId_5630_48 1 chr17:72469966_A_G rs2272111 cis 17 72469966 A G 0.2017 -0.6174 0.0152 1.07e-360 'CMRF35-like molecule 8 ENSG00000167851 'CD300A missense_variant ENSG00000167851 ENSG00000167851 'CD300A 3 known specific_protein CD300A chr17 74466399 74484794 1 11314 protein_coding 17:74473827 7428 512_2_1 SeqId_12560_9 'NT5C chr17:73140941_A_G$SeqId_12560_9 1 chr17:73140941_A_G rs78625720 cis 17 73140941 A G 0.0308 -1.7173 0.0346 1.90e-537 '5'(3')-deoxyribonucleotidase, cytosolic type ENSG00000125458 'NT5C intron_variant 1.0 rs11541956 ENSG00000125458 'NT5C missense_variant ENSG00000125458 ENSG00000125458 'NT5C 3 known specific_protein NT5C chr17 75130225 75131757 -1 30833 protein_coding 17:75144846 13089 512_2_3 SeqId_4294_16 'Sphingosine kinase 1 chr17:74319057_C_G$SeqId_4294_16 1 chr17:74319057_C_G rs145998624 cis 17 74319057 C G 0.0133 -0.4831 0.0579 7.1e-17 'Sphingosine kinase 1 ENSG00000176170 'SPHK1 intron_variant 0.361557 rs549579958 ENSG00000176170 'SPHK1 frameshift_variant ENSG00000176170 ENSG00000176170 'SPHK1 3 novel specific_protein SPHK1 chr17 76376584 76387860 1 8877 protein_coding 17:76322976 53608 512_2_4 SeqId_9478_69 'KPRA chr17:74335069_A_G$SeqId_9478_69 1 chr17:74335069_A_G rs388283 cis 17 74335069 A G 0.2145 0.1413 0.016 1.25e-18 'Phosphoribosyl pyrophosphate synthase-associated protein 1 ENSG00000161542 'PRPSAP1 intron_variant ENSG00000161542 ENSG00000161542 'PRPSAP1 3 novel specific_protein PRPSAP1 chr17 76309478 76384521 -1 5635 protein_coding 17:76338988 45533 512_3_1 SeqId_8005_1 'MXRA7 chr17:74694446_C_G$SeqId_8005_1 1 chr17:74694446_C_G rs4789346 cis 17 74694446 C G 0.5097 0.3858 0.0126 3.44e-205 'Matrix-remodeling-associated protein 7 ENSG00000182534 'MXRA7 intron_variant ENSG00000182534 ENSG00000182534 'MXRA7 3 known specific_protein MXRA7 chr17 76672551 76711004 -1 439921 protein_coding 17:76698364 12640 513_1_1 SeqId_5000_52 'LG3BP chr17:76962761_C_T$SeqId_5000_52 1 chr17:76962761_C_T rs111526614 cis 17 76962761 T C 0.02 -0.6399 0.0517 3.77e-35 'Galectin-3-binding protein ENSG00000108679 'LGALS3BP downstream_gene_variant ENSG00000108679 ENSG00000108679 'LGALS3BP 3 novel suggestive_specific_pathway LGALS3BP chr17 78971238 78979947 -1 3959 protein_coding 17:78966679 13268 513_1_2 SeqId_16781_2 'ENASE chr17:77071040_A_C$SeqId_16781_2 1 chr17:77071040_A_C rs56107536 cis 17 77071040 A C 0.1336 0.7285 0.0183 1.52e-346 'Cytosolic endo-beta-N-acetylglucosaminidase ENSG00000167280 'ENGASE missense_variant ENSG00000167280 ENSG00000167280 'ENGASE 3 known suggestive_specific_pathway ENGASE chr17 79074824 79088599 1 64772 protein_coding 17:79074958 134 513_2_1 SeqId_4435_66 'ENPP7 chr17:77704314_C_T$SeqId_4435_66 1 chr17:77704314_C_T rs8076533 cis 17 77704314 T C 0.3659 0.9325 0.0106 2.82e-1683 'Ectonucleotide pyrophosphatase/phosphodiesterase family member 7 ENSG00000182156 'ENPP7 upstream_gene_variant 0.970839 rs8074547 ENSG00000182156 'ENPP7 missense_variant ENSG00000182156 ENSG00000182156 'ENPP7 3 known specific_protein 0.96274 0.051407 3.10455958812834e-59 yes ENPP7 Olink METABOLISM(v.3402) ENPP7 chr17 79730943 79742219 1 339221 protein_coding 17:79730552 391 513_2_2 SeqId_9385_4 'GAA chr17:78075462_C_G$SeqId_9385_4 1 chr17:78075462_C_G rs2304849 cis 17 78075462 C G 0.2407 -0.6174 0.0149 2.82e-375 'Lysosomal alpha-glucosidase ENSG00000171298 'GAA upstream_gene_variant 0.122378 rs1042395 ENSG00000171298 'GAA missense_variant ENSG00000171298 ENSG00000171298 'GAA 3 known specific_protein GAA chr17 80101556 80119881 1 2548 protein_coding 17:80101663 107 513_2_3 SeqId_9256_78 'NPTX1 chr17:78538558_C_G$SeqId_9256_78 1 chr17:78538558_C_G rs111307499 cis 17 78538558 C G 0.9186 -0.6162 0.0234 2.67e-152 'Neuronal pentraxin-1 ENSG00000171246 'NPTX1 intron_variant ENSG00000171246 ENSG00000171246 'NPTX1 3 known specific_protein NPTX1 chr17 80466834 80477843 -1 4884 protein_coding 17:80564758 86915 513_3_1 SeqId_7947_19 'AP4AT chr17:79205421_A_G$SeqId_7947_19 1 chr17:79205421_A_G rs61745945 cis 17 79205421 A G 0.0142 -0.589 0.0584 6.13e-24 'AP-4 complex accessory subunit tepsin ENSG00000167302 'ENTHD2 missense_variant ENSG00000167302 ENSG00000167302 'TEPSIN 3 known specific_protein TEPSIN chr17 81228277 81239091 -1 146705 protein_coding 17:81231621 7470 513_3_3 SeqId_8252_2 'NOTUM chr17:79924552_A_C$SeqId_8252_2 1 chr17:79924552_A_C rs74002709 cis 17 79924552 A C 0.0491 -0.3862 0.033 1.26e-31 'Palmitoleoyl-protein carboxylesterase NOTUM ENSG00000185269 'NOTUM upstream_gene_variant ENSG00000185269 ENSG00000185269 'NOTUM 3 known specific_protein NOTUM chr17 81952507 81961840 -1 147111 protein_coding 17:81966676 4836 513_3_4 SeqId_17758_79 'DCXR chr17:79993388_C_T$SeqId_17758_79 1 chr17:79993388_C_T rs60390379 cis 17 79993388 T C 0.1236 0.2601 0.0188 1.69e-43 'L-xylulose reductase ENSG00000169738 'DCXR downstream_gene_variant ENSG00000169738 ENSG00000169738 'DCXR 3 novel specific_protein DCXR chr17 82035136 82037709 -1 51181 protein_coding 17:82035512 2197 513_4_1 SeqId_8403_18 'Fatty acid synthase chr17:80059758_A_G$SeqId_8403_18 1 chr17:80059758_A_G rs7225637 cis 17 80059758 A G 0.5457 -0.231 0.0124 1.74e-77 'Fatty acid synthase ENSG00000169710 'FASN upstream_gene_variant ENSG00000169710 ENSG00000169710 'FASN 3 known specific_protein FASN chr17 82078338 82098294 -1 2194 protein_coding 17:82101882 3588 513_4_2 SeqId_12008_3 'CD7 chr17:80272491_C_T$SeqId_12008_3 1 chr17:80272491_C_T rs3176831 cis 17 80272491 T C 0.0446 -0.8035 0.0313 4.62e-145 'T-cell antigen CD7 ENSG00000173762 'CD7 downstream_gene_variant 0.972107 rs555569626 ENSG00000173762 'CD7 frameshift_variant ENSG00000173762 ENSG00000173762 'CD7 3 known specific_pathway CD7 chr17 82314868 82317608 -1 924 protein_coding 17:82314615 2993 513_4_3 SeqId_13093_6 'SECTM1 chr17:80289284_A_G$SeqId_13093_6 1 chr17:80289284_A_G rs4789763 cis 17 80289284 A G 0.4987 -0.3251 0.0133 7.87e-132 'Secreted and transmembrane protein 1 ENSG00000141574 'SECTM1 intron_variant ENSG00000141574 ENSG00000141574 'SECTM1 3 known specific_pathway SECTM1 chr17 82321024 82334074 -1 6398 protein_coding 17:82331408 2666 513_4_5 SeqId_4278_14 'Protein disulfide-isomerase chr17:80356895_D_I$SeqId_4278_14 1 chr17:80356895_D_I rs149626452 trans 17 80356895 D I 0.4619 -0.1926 0.0135 3.55e-46 'Protein disulfide-isomerase ENSG00000185624 'P4HB intron_variant 0.467422 rs62079523 ENSG00000181396 'OGFOD3 missense_variant ENSG00000141551|ENSG00000169710|ENSG00000181408 ENSG00000141551|ENSG00000169710|ENSG00000181408 'CSNK1D|FASN|UTS2R 1 known specific_pathway -0.070269 0.063662 0.270240228847107 no P4HB Olink DEVELOPMENT(v.3511) P4HB chr17 81843159 81860856 -1 5034 protein_coding 17:82399020 538164 514_1_1 SeqId_5457_5 'COLEC12 chr18:400766_C_T$SeqId_5457_5 1 chr18:400766_C_T rs7243583 cis 18 400766 T C 0.2644 -0.1231 0.0144 1.33e-17 'Collectin-12 ENSG00000158270 'COLEC12 intron_variant ENSG00000158270 ENSG00000158270 'COLEC12 3 novel specific_protein COLEC12 chr18 316737 500722 -1 81035 protein_coding 18:400766 99956 516_1_1 SeqId_13597_20 'RAB31 chr18:9696474_C_T$SeqId_13597_20 1 chr18:9696474_C_T rs12607866 cis 18 9696474 T C 0.7309 -0.3484 0.0141 3.64e-134 'Ras-related protein Rab-31 ENSG00000168461 'RAB31 regulatory_region_variant ENSG00000168461 ENSG00000168461 'RAB31 4 novel specific_pathway RAB31 chr18 9708275 9862551 1 11031 protein_coding 18:9696477 11798 516_1_2 SeqId_17773_26 'SNAG chr18:10485357_C_T$SeqId_17773_26 1 chr18:10485357_C_T rs489837 cis 18 10485357 T C 0.5532 0.1026 0.0129 1.87e-15 'Gamma-soluble NSF attachment protein ENSG00000134265 'NAPG intron_variant ENSG00000134265 ENSG00000134265|ENSG00000154856 'APCDD1|NAPG 3 novel suggestive_specific_pathway NAPG chr18 10525905 10552764 1 8774 protein_coding 18:10485360 40545 516_1_2 SeqId_6599_5 'APCD1 chr18:10481941_A_G$SeqId_6599_5 1 chr18:10481941_A_G rs1786682 cis 18 10481941 A G 0.4652 -0.0968 0.0136 9.82e-13 'Protein APCDD1 ENSG00000154856 'APCDD1 intron_variant 0.139951 rs3748415 ENSG00000154856 'APCDD1 missense_variant ENSG00000154856 ENSG00000134265|ENSG00000154856 'APCDD1|NAPG 3 novel suggestive_specific_pathway APCDD1 chr18 10454635 10489949 1 147495 protein_coding 18:10481944 27309 516_1_3 SeqId_9234_8 'TWSG1 chr18:9174885_A_G$SeqId_9234_8 1 chr18:9174885_A_G rs4798783 cis 18 9174885 A G 0.7047 0.2802 0.0137 4.29e-93 'Twisted gastrulation protein homolog 1 ENSG00000128791 'TWSG1 intron_variant ENSG00000128791 ENSG00000128791 'TWSG1 3 novel specific_protein TWSG1 chr18 9334767 9402420 1 57045 protein_coding 18:9174887 159880 519_1_1 SeqId_11646_4 'Carbohydrate sulfotransferase 9 chr18:24681610_D_I$SeqId_11646_4 1 chr18:24681610_D_I rs56348115 cis 18 24681610 D I 0.324 0.3056 0.0135 3.29e-113 'Carbohydrate sulfotransferase 9 ENSG00000154080 'CHST9 intron_variant ENSG00000154080 ENSG00000154080 'CHST9 4 known unspecific_effect CHST9 chr18 26906481 27185308 -1 83539 protein_coding 18:27101647 83661 52_2_3 SeqId_7980_72 'B3GN2 chr2:62567995_D_I$SeqId_7980_72 1 chr2:62567995_D_I rs112392179 cis 2 62567995 D I 0.5835 -0.2155 0.0136 1.84e-56 'N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2 ENSG00000170340 'B3GNT2 regulatory_region_variant ENSG00000170340 ENSG00000170340 'B3GNT2 3 novel unspecific_effect B3GNT2 chr2 62196115 62224731 1 10678 protein_coding 2:62340861 144746 52_2_4 SeqId_12813_18 'EHBP1 chr2:62727986_A_C$SeqId_12813_18 1 chr2:62727986_A_C rs73934251 cis 2 62727986 A C 0.1152 0.1577 0.0207 2.93e-14 'EH domain-binding protein 1 ENSG00000115504 'EHBP1 3_prime_UTR_variant ENSG00000115504 ENSG00000115504 'EHBP1 3 novel specific_protein EHBP1 chr2 62673851 63046487 1 23301 protein_coding 2:62500851 173000 520_1_1 SeqId_13126_52 'DSC2 chr18:28689144_A_G$SeqId_13126_52 1 chr18:28689144_A_G rs4799305 cis 18 28689144 A G 0.8753 -0.3103 0.02 4.14e-54 'Desmocollin-2 ENSG00000134755 'DSC2 intron_variant,non_coding_transcript_variant ENSG00000134755 ENSG00000134755 'DSC2 3 known specific_protein DSC2 chr18 31058840 31102522 -1 1824 protein_coding 18:31109181 6659 520_1_2 SeqId_9484_75 'Desmoglein-2 chr18:29078516_A_C$SeqId_9484_75 1 chr18:29078516_A_C rs9945420 cis 18 29078516 A C 0.6253 0.1918 0.0128 2.02e-50 'Desmoglein-2 ENSG00000046604 'DSG2 intron_variant ENSG00000046604 ENSG00000046604 'DSG2 3 known specific_protein DSG2 chr18 31498177 31549008 1 1829 protein_coding 18:31498553 376 520_1_4 SeqId_10832_24 'B4GT6 chr18:29216314_G_T$SeqId_10832_24 1 chr18:29216314_G_T rs113222817 cis 18 29216314 T G 0.9578 0.945 0.0291 9.25e-231 'Beta-1,4-galactosyltransferase 6 ENSG00000118276 'B4GALT6 intron_variant 0.99203 rs34683195 ENSG00000118276 'B4GALT6 missense_variant ENSG00000118276 ENSG00000118276 'B4GALT6 3 known specific_protein B4GALT6 chr18 31622246 31685836 -1 9331 protein_coding 18:31636351 49485 521_1_1 SeqId_16856_79 'MARE2 chr18:32690756_A_T$SeqId_16856_79 1 chr18:32690756_A_T rs1443641 cis 18 32690756 A T 0.5416 0.2134 0.0128 1.02e-62 'Microtubule-associated protein RP/EB family member 2 ENSG00000166974 'MAPRE2 intron_variant ENSG00000166974 ENSG00000166974 'MAPRE2 3 novel specific_protein MAPRE2 chr18 34976928 35143470 1 10982 protein_coding 18:35110792 133864 522_2_1 SeqId_13472_35 'HDHD2 chr18:44679781_C_T$SeqId_13472_35 1 chr18:44679781_C_T rs75934126 cis 18 44679781 T C 0.9422 -0.4377 0.0256 2.52e-65 'Haloacid dehalogenase-like hydrolase domain-containing protein 2 ENSG00000167220 'HDHD2 upstream_gene_variant ENSG00000167220 ENSG00000167220 'HDHD2 3 known specific_protein HDHD2 chr18 47107408 47150500 -1 84064 protein_coding 18:47153410 2910 524_1_1 SeqId_13536_56 'POLI chr18:51807260_A_G$SeqId_13536_56 1 chr18:51807260_A_G rs3218784 cis 18 51807260 A G 0.9717 0.72 0.0409 2.35e-69 'DNA polymerase iota ENSG00000101751 'POLI missense_variant ENSG00000101751 ENSG00000101751 'POLI 3 novel specific_protein POLI chr18 54269517 54321266 1 11201 protein_coding 18:54280890 11373 526_1_1 SeqId_15417_3 'Maspin chr18:61156606_C_G$SeqId_15417_3 1 chr18:61156606_C_G rs12454742 cis 18 61156606 C G 0.693 0.1947 0.0144 1.48e-41 'Serpin B5 ENSG00000206075 'SERPINB5 synonymous_variant 0.993507 rs2289519 ENSG00000206075 'SERPINB5 missense_variant ENSG00000206075 ENSG00000206075 'SERPINB5 3 novel specific_protein SERPINB5 chr18 63476958 63505085 1 5268 protein_coding 18:63489373 12415 526_1_2 SeqId_18841_1 'SPB13 chr18:61253961_A_G$SeqId_18841_1 1 chr18:61253961_A_G rs77157727 cis 18 61253961 A G 0.0341 -0.3118 0.0369 2.78e-17 'Serpin B13 ENSG00000197641 'SERPINB13 upstream_gene_variant ENSG00000197641 ENSG00000197641 'SERPINB13 3 novel specific_protein SERPINB13 chr18 63586989 63604639 1 5275 protein_coding 18:63586727 262 526_1_3 SeqId_19130_81 'SPB8 chr18:61633244_C_T$SeqId_19130_81 1 chr18:61633244_C_T rs2009989 cis 18 61633244 T C 0.7868 0.3859 0.0153 5.1e-140 'Serpin B8 ENSG00000166401 'SERPINB8 upstream_gene_variant ENSG00000166401 ENSG00000166401 'SERPINB8 3 novel specific_protein 0.18632 0.077953 0.0172226509552665 yes SERPINB8 Olink METABOLISM(v.3402) SERPINB8 chr18 63970029 64019779 1 5271 protein_coding 18:63966010 4019 527_1_1 SeqId_11287_14 'Cytochrome b5 chr18:71971217_D_I$SeqId_11287_14 1 chr18:71971217_D_I rs36049221 cis 18 71971217 D I 0.3395 -0.1446 0.0143 6.42e-24 'Cytochrome b5 ENSG00000166347 'CYB5A regulatory_region_variant ENSG00000166347 ENSG00000166347 'CYB5A 3 known specific_protein CYB5A chr18 74250846 74291973 -1 1528 protein_coding 18:74303983 12010 527_2_1 SeqId_5456_59 'CNDP1 chr18:72209543_A_G$SeqId_5456_59 1 chr18:72209543_A_G rs17817077 cis 18 72209543 A G 0.393 0.3514 0.0137 4.12e-145 'Beta-Ala-His dipeptidase ENSG00000150656 'CNDP1 intron_variant 0.166524 rs11151964 ENSG00000150656 'CNDP1 missense_variant ENSG00000150656 ENSG00000150656 'CNDP1 3 known specific_protein 0.30271 0.064773 3.84591782045354e-06 yes CNDP1 Olink CARDIOMETABOLIC(v.3602) CNDP1 chr18 74534500 74587212 1 84735 protein_coding 18:74542308 7808 527_2_2 SeqId_17345_12 'ZADH2 chr18:72910687_C_T$SeqId_17345_12 1 chr18:72910687_C_T rs9240 cis 18 72910687 T C 0.5764 0.1963 0.0126 7.93e-55 'Prostaglandin reductase 3 ENSG00000180011 'ZADH2 3_prime_UTR_variant ENSG00000180011 ENSG00000180011 'ZADH2 3 novel specific_protein ZADH2 chr18 75195113 75209139 -1 284273 protein_coding 18:75198732 10407 529_1_1 SeqId_5704_74 'Granzyme M chr19:531115_C_T$SeqId_5704_74 1 chr19:531115_C_T rs16989724 cis 19 531115 T C 0.9339 0.2732 0.028 1.97e-22 'Granzyme M ENSG00000197540 'GZMM upstream_gene_variant 0.107523 rs1599882 ENSG00000197540 'GZMM missense_variant ENSG00000197540 ENSG00000197540 'GZMM 3 known specific_protein GZMM chr19 544034 549924 1 3004 protein_coding 19:531115 12919 529_2_1 SeqId_17200_50 'KI2L1 chr19:860766_A_G$SeqId_17200_50 1 chr19:860766_A_G rs35186399 trans 19 860766 A G 0.0114 -0.5291 0.0698 3.35e-14 'Killer cell immunoglobulin-like receptor 2DL1 ENSG00000125498 'KIR2DL1 missense_variant ENSG00000197766 ENSG00000197766 'CFD 4 novel unspecific_effect KIR2DL1 chr19 54769793 54784322 1 3802 protein_coding 19:860766 53909027 529_2_1 SeqId_11459_81 'ELL chr19:860766_A_G$SeqId_11459_81 1 chr19:860766_A_G rs35186399 trans 19 860766 A G 0.0114 -0.5381 0.0697 1.17e-14 'RNA polymerase II elongation factor ELL ENSG00000105656 'ELL missense_variant ENSG00000197766 ENSG00000197766 'CFD 4 novel unspecific_effect ELL chr19 18442663 18522116 -1 8178 protein_coding 19:860766 17661350 529_2_1 SeqId_13539_131 'KCNN1 chr19:886743_C_T$SeqId_13539_131 1 chr19:886743_C_T rs35267984 trans 19 886743 T C 0.0114 -0.4954 0.0709 2.72e-12 'Small conductance calcium-activated potassium channel protein 1 ENSG00000105642 'KCNN1 intron_variant 0.894762 rs35186399 ENSG00000197766 'CFD missense_variant ENSG00000197766 ENSG00000197766 'CFD 4 novel unspecific_effect KCNN1 chr19 17951293 18000085 1 3780 protein_coding 19:886743 17064550 529_2_1 SeqId_13994_1 'FBRL chr19:860766_A_G$SeqId_13994_1 1 chr19:860766_A_G rs35186399 trans 19 860766 A G 0.0114 -0.4917 0.0697 1.7e-12 'rRNA 2'-O-methyltransferase fibrillarin ENSG00000105202 'FBL missense_variant ENSG00000197766 ENSG00000197766 'CFD 4 novel unspecific_effect FBL chr19 39834458 39846379 -1 2091 protein_coding 19:860766 38985613 529_2_1 SeqId_16854_17 'LSM4 chr19:886743_C_T$SeqId_16854_17 1 chr19:886743_C_T rs35267984 trans 19 886743 T C 0.0114 -0.6191 0.0702 1.09e-18 'U6 snRNA-associated Sm-like protein LSm4 ENSG00000130520 'LSM4 intron_variant 0.894762 rs35186399 ENSG00000197766 'CFD missense_variant ENSG00000197766|ENSG00000011304|ENSG00000099817 ENSG00000197766 'CFD 4 novel unspecific_effect LSM4 chr19 18306236 18323112 -1 25804 protein_coding 19:886743 17436369 529_2_1 SeqId_17209_27 'ST2B1 chr19:860766_A_G$SeqId_17209_27 1 chr19:860766_A_G rs35186399 trans 19 860766 A G 0.0114 -0.524 0.0694 4.48e-14 'Sulfotransferase family cytosolic 2B member 1 ENSG00000088002 'SULT2B1 missense_variant ENSG00000197766 ENSG00000197766 'CFD 4 novel unspecific_effect SULT2B1 chr19 48552172 48599425 1 6820 protein_coding 19:860766 47691406 529_2_1 SeqId_18306_1 'PALM chr19:860766_A_G$SeqId_18306_1 1 chr19:860766_A_G rs35186399 cis 19 860766 A G 0.0114 -0.5593 0.0697 9.94e-16 'Paralemmin-1 ENSG00000099864 'PALM missense_variant ENSG00000099864 ENSG00000197766 'CFD 4 novel unspecific_effect PALM chr19 708935 748329 1 5064 protein_coding 19:860766 151831 529_2_1 SeqId_7910_41 'LRFN1 chr19:860766_A_G$SeqId_7910_41 1 chr19:860766_A_G rs35186399 trans 19 860766 A G 0.0114 -0.4725 0.0691 8.14e-12 'Leucine-rich repeat and fibronectin type III domain-containing protein 1 ENSG00000128011 'LRFN1 missense_variant ENSG00000197766 ENSG00000197766 'CFD 4 novel unspecific_effect LRFN1 chr19 39306566 39320863 -1 57622 protein_coding 19:860766 38460097 529_2_1 SeqId_3199_54 'kallikrein 12 chr19:886743_C_T$SeqId_3199_54 1 chr19:886743_C_T rs35267984 trans 19 886743 T C 0.0114 -0.5922 0.0691 9.92e-18 'Kallikrein-12 ENSG00000186474 'KLK12 intron_variant 0.894762 rs35186399 ENSG00000197766 'CFD missense_variant ENSG00000197766 ENSG00000197766 'CFD 4 novel unspecific_effect KLK12 chr19 51029092 51035230 -1 43849 protein_coding 19:886743 50148487 529_2_1 SeqId_3450_4 'Kallikrein 6 chr19:886743_C_T$SeqId_3450_4 1 chr19:886743_C_T rs35267984 trans 19 886743 T C 0.0114 -0.5494 0.069 1.76e-15 'Kallikrein-6 ENSG00000167755 'KLK6 intron_variant 0.894762 rs35186399 ENSG00000197766 'CFD missense_variant ENSG00000197766 ENSG00000197766 'CFD 4 novel unspecific_effect KLK6 chr19 50958631 50969673 -1 5653 protein_coding 19:886743 50082930 529_2_1 SeqId_6283_60 'MCEM1 chr19:886743_C_T$SeqId_6283_60 1 chr19:886743_C_T rs35267984 trans 19 886743 T C 0.0114 -0.5283 0.071 9.88e-14 'Mast cell-expressed membrane protein 1 ENSG00000183019 'C19orf59 intron_variant 0.894762 rs35186399 ENSG00000197766 'CFD missense_variant ENSG00000175221|ENSG00000197766 ENSG00000197766 'CFD 4 novel unspecific_effect MCEMP1 chr19 7677088 7679829 1 199675 protein_coding 19:886743 6790345 529_2_1 SeqId_6961_14 'IGFL3 chr19:886743_C_T$SeqId_6961_14 1 chr19:886743_C_T rs35267984 trans 19 886743 T C 0.0114 -0.6188 0.0699 8.5e-19 'Insulin growth factor-like family member 3 ENSG00000188624 'IGFL3 intron_variant 0.894762 rs35186399 ENSG00000197766 'CFD missense_variant ENSG00000197766 ENSG00000197766 'CFD 4 novel unspecific_effect IGFL3 chr19 46120067 46124688 -1 388555 protein_coding 19:886743 45237945 529_2_10 SeqId_13544_9 'HMHA1 chr19:1077985_A_G$SeqId_13544_9 1 chr19:1077985_A_G rs7251797 cis 19 1077985 A G 0.6177 -0.2007 0.0136 4.29e-49 'Rho GTPase-activating protein 45 ENSG00000180448 'HMHA1 missense_variant ENSG00000180448 ENSG00000180448 'ARHGAP45 3 known specific_protein ARHGAP45 chr19 1065923 1086628 1 23526 protein_coding 19:1077986 12063 529_2_11 SeqId_18310_26 'SELW chr19:1105621_D_I$SeqId_18310_26 1 chr19:1105621_D_I rs8178973 trans 19 1105621 D I 0.8193 0.1346 0.0177 2.86e-14 'Selenoprotein W ENSG00000178980 'SEPW1 intron_variant ENSG00000167468 ENSG00000167468 'GPX4 3 novel specific_protein SELENOW chr19 47778677 47784686 1 6415 protein_coding 19:1105623 46673054 529_2_3 SeqId_8351_17 'PRS57 chr19:689590_C_G$SeqId_8351_17 1 chr19:689590_C_G rs9304936 cis 19 689590 C G 0.2922 -0.5547 0.0141 1.72e-338 'Serine protease 57 ENSG00000185198 'PRSS57 intron_variant 0.140649 rs72618588 ENSG00000185198 'PRSS57 missense_variant ENSG00000185198 ENSG00000185198 'PRSS57 3 known specific_protein PRSS57 chr19 685546 695498 -1 400668 protein_coding 19:689590 5908 529_2_4 SeqId_3438_10 'FSTL3 chr19:692790_A_G$SeqId_3438_10 1 chr19:692790_A_G rs112418024 cis 19 692790 A G 0.028 -0.3012 0.0423 1.07e-12 'Follistatin-related protein 3 ENSG00000070404 'FSTL3 intron_variant ENSG00000070404 ENSG00000070404 'FSTL3 3 novel specific_protein -0.36734 0.1747 0.0360163750394728 yes FSTL3 Olink DEVELOPMENT(v.3511) FSTL3 chr19 676392 683392 1 10272 protein_coding 19:692790 16398 529_2_6 SeqId_13720_95 'Proteinase-3 chr19:845535_C_G$SeqId_13720_95 1 chr19:845535_C_G rs6510982 cis 19 845535 C G 0.2459 -0.7142 0.0162 1.61e-424 'Myeloblastin ENSG00000196415 'PRTN3 intron_variant 0.232769 rs351111 ENSG00000196415 'PRTN3 missense_variant ENSG00000196415 ENSG00000196415 'PRTN3 3 known specific_protein -0.49814 0.074702 7.07945784384137e-11 yes PRTN3 Olink CARDIOVASCULAR III(v.6112) PRTN3 chr19 840999 848175 1 5657 protein_coding 19:845535 4536 529_2_7 SeqId_13671_40 'Elastase chr19:850733_C_G$SeqId_13671_40 1 chr19:850733_C_G rs10409474 cis 19 850733 C G 0.8964 -0.4001 0.0242 2.28e-61 'Neutrophil elastase ENSG00000197561 'ELANE upstream_gene_variant ENSG00000197561 ENSG00000197561 'ELANE 3 novel specific_protein ELANE chr19 851014 856247 1 1991 protein_coding 19:850733 281 529_2_8 SeqId_2946_52 'Factor D chr19:859368_G_T$SeqId_2946_52 1 chr19:859368_G_T rs71335276 cis 19 859368 T G 0.2382 -0.1679 0.0166 4.48e-24 'Complement factor D ENSG00000197766 'CFD upstream_gene_variant ENSG00000197766 ENSG00000197766 'CFD 3 known suggestive_specific_pathway CFD chr19 859664 863641 1 1675 protein_coding 19:859368 296 53_1_1 SeqId_18236_3 'LEGL chr2:64568900_A_C$SeqId_18236_3 1 chr2:64568900_A_C rs76392037 cis 2 64568900 A C 0.944 -0.2217 0.0283 4.54e-15 'Galectin-related protein ENSG00000119862 'LGALSL upstream_gene_variant ENSG00000119862 ENSG00000119862 'LGALSL 3 novel specific_protein LGALSL chr2 64453969 64461381 1 29094 protein_coding 2:64341766 112203 53_2_1 SeqId_19223_6 'RAB1A chr2:65313215_D_I$SeqId_19223_6 1 chr2:65313215_D_I rs3052195 cis 2 65313215 D I 0.2538 -0.1302 0.0152 8.54e-18 'Ras-related protein Rab-1A ENSG00000138069 'RAB1A 3_prime_UTR_variant ENSG00000138069 ENSG00000138069 'RAB1A 3 novel specific_protein RAB1A chr2 65070696 65130331 -1 5861 protein_coding 2:65086082 44249 530_1_1 SeqId_18396_10 'AES chr19:3062857_C_T$SeqId_18396_10 1 chr19:3062857_C_T rs11539938 cis 19 3062857 T C 0.5761 0.1104 0.0152 3.13e-13 'Amino-terminal enhancer of split ENSG00000104964 'AES synonymous_variant ENSG00000104964 ENSG00000104964 'TLE5 3 novel specific_protein TLE5 chr19 3052910 3063107 -1 166 protein_coding 19:3062859 248 530_1_2 SeqId_10948_14 'PLD3 chr19:3546264_C_T$SeqId_10948_14 1 chr19:3546264_C_T rs34878396 trans 19 3546264 T C 0.0107 0.5768 0.0648 5.28e-19 'Phospholipase D3 ENSG00000105223 'PLD3 missense_variant ENSG00000161091 ENSG00000161091 'MFSD12 3 novel specific_protein PLD3 chr19 40348456 40380439 1 23646 protein_coding 19:3546266 36802190 530_1_3 SeqId_11551_16 'HM20B chr19:3579841_C_T$SeqId_11551_16 1 chr19:3579841_C_T rs76422466 cis 19 3579841 T C 0.0142 -0.5113 0.0605 2.84e-17 'SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related ENSG00000064961 'HMG20B downstream_gene_variant ENSG00000064961 ENSG00000064961 'HMG20B 3 novel specific_protein HMG20B chr19 3572777 3579088 1 10362 protein_coding 19:3579843 7066 530_1_4 SeqId_10851_77 'IL27B chr19:4236388_A_G$SeqId_10851_77 1 chr19:4236388_A_G rs353705 cis 19 4236388 A G 0.2841 -1.0179 0.011 3.22e-1862 'Interleukin-27 subunit beta ENSG00000105246 'EBI3 intron_variant 0.997814 rs4740 ENSG00000105246 'EBI3 missense_variant ENSG00000105246 ENSG00000105246 'EBI3 3 known specific_protein EBI3 chr19 4229523 4237528 1 10148 protein_coding 19:4236391 6868 530_2_1 SeqId_5121_3 'SEM6B chr19:4544645_A_T$SeqId_5121_3 1 chr19:4544645_A_T rs28731213 cis 19 4544645 A T 0.4932 0.1007 0.0137 1.67e-13 'Semaphorin-6B ENSG00000167680 'SEMA6B intron_variant ENSG00000167680 ENSG00000167680 'SEMA6B 4 known unspecific_effect SEMA6B chr19 4542593 4581776 -1 10501 protein_coding 19:4544633 37143 530_2_2 SeqId_9248_36 'CS010 chr19:4701727_C_T$SeqId_9248_36 1 chr19:4701727_C_T rs75029446 cis 19 4701727 T C 0.0202 -0.4696 0.0462 3.02e-24 'Myeloid-derived growth factor ENSG00000074842 'C19orf10 intron_variant 0.200612 rs2270090 ENSG00000074842 'C19orf10 missense_variant ENSG00000074842 ENSG00000074842 'MYDGF 3 novel specific_protein MYDGF chr19 4641374 4670362 -1 56005 protein_coding 19:4701715 31353 531_1_1 SeqId_4548_4 'Fucosyltransferase 3 chr19:5840619_C_T$SeqId_4548_4 1 chr19:5840619_C_T rs708686 cis 19 5840619 T C 0.2785 -0.7748 0.0133 1.58e-739 'Galactoside 3(4)-L-fucosyltransferase ENSG00000171124 'FUT3 upstream_gene_variant 0.540205 rs812936 ENSG00000171124 'FUT3 missense_variant ENSG00000171124 ENSG00000171124 'FUT3 3 known unspecific_effect FUT3 chr19 5842888 5851471 -1 2525 protein_coding 19:5840608 10863 531_1_4 SeqId_4549_78 'FUT5 chr19:5866073_A_C$SeqId_4549_78 1 chr19:5866073_A_C rs8101625 cis 19 5866073 A C 0.6063 -0.391 0.0133 2.27e-189 'Alpha-(1,3)-fucosyltransferase 5 ENSG00000130383 'FUT5 downstream_gene_variant 0.438903 rs4807054 ENSG00000130383 'FUT5 missense_variant ENSG00000130383 ENSG00000130383 'FUT5 3 novel specific_protein FUT5 chr19 5865826 5870540 -1 2527 protein_coding 19:5866062 4478 531_1_6 SeqId_5355_69 'LIGHT chr19:6675989_A_G$SeqId_5355_69 1 chr19:6675989_A_G rs413141 cis 19 6675989 A G 0.136 0.3783 0.0194 1.47e-84 'Tumor necrosis factor ligand superfamily member 14 ENSG00000125735 'TNFSF14 downstream_gene_variant ENSG00000125735 ENSG00000125735 'TNFSF14 3 known specific_protein 0.27791 0.09219 0.00270956765904605 yes TNFSF14 Olink INFLAMMATION(v.3012) TNFSF14 chr19 6661253 6670588 -1 8740 protein_coding 19:6675978 5390 531_2_1 SeqId_4900_8 'C3a chr19:6710451_A_G$SeqId_4900_8 1 chr19:6710451_A_G rs555701698 cis 19 6710451 A G 0.1698 -0.1253 0.018 3.54e-12 'C3a anaphylatoxin ENSG00000125730 'C3 intron_variant ENSG00000125730 ENSG00000125730 'C3 3 known suggestive_specific_pathway C3 chr19 6677704 6730562 -1 718 protein_coding 19:6710440 20122 531_2_2 SeqId_5803_24 'C3d chr19:6716279_A_G$SeqId_5803_24 1 chr19:6716279_A_G rs11569415 cis 19 6716279 A G 0.2131 0.2368 0.0166 5.41e-46 'Complement C3d fragment ENSG00000125730 'C3 intron_variant 0.951926 rs2230199 ENSG00000125730 'C3 missense_variant ENSG00000125730 ENSG00000125730 'C3 7 known unspecific_effect C3 chr19 6677704 6730562 -1 718 protein_coding 19:6716268 14294 531_2_2 SeqId_4480_59 'C3b chr19:6718387_C_G$SeqId_4480_59 1 chr19:6718387_C_G rs2230199 cis 19 6718387 C G 0.2071 -0.1342 0.0161 8.53e-17 'Complement C3b ENSG00000125730 'C3 missense_variant ENSG00000125730 ENSG00000125730 'C3 7 known unspecific_effect C3 chr19 6677704 6730562 -1 718 protein_coding 19:6718376 12186 531_2_3 SeqId_2683_1 'iC3b chr19:6697088_A_T$SeqId_2683_1 1 chr19:6697088_A_T rs5826945 cis 19 6697088 A T 0.856 0.1613 0.0186 3.72e-18 'Complement C3b, inactivated ENSG00000125730 'C3 intron_variant ENSG00000125730 ENSG00000125730 'C3 3 known suggestive_specific_pathway C3 chr19 6677704 6730562 -1 718 protein_coding 19:6697077 33485 531_2_6 SeqId_3046_31 'resistin chr19:7735297_A_G$SeqId_3046_31 1 chr19:7735297_A_G rs3745368 cis 19 7735297 A G 0.0306 -0.5019 0.0406 4.83e-35 'Resistin ENSG00000104918 'RETN 3_prime_UTR_variant ENSG00000104918 ENSG00000104918 'RETN 3 known specific_protein -1.0095 0.19051 1.77459805015172e-07 yes RETN Olink CARDIOVASCULAR III(v.6112) RETN chr19 7669049 7670455 1 56729 protein_coding 19:7670411 1362 531_2_7 SeqId_3291_30 'CD23 chr19:7759715_C_G$SeqId_3291_30 1 chr19:7759715_C_G rs11260014 cis 19 7759715 C G 0.4903 -0.3296 0.0135 2.13e-131 'Low affinity immunoglobulin epsilon Fc receptor ENSG00000104921 'FCER2 intron_variant 0.149488 rs2228137 ENSG00000104921 'FCER2 missense_variant ENSG00000104921 ENSG00000104921 'FCER2 3 known specific_protein -0.30623 0.059305 3.54405130280993e-07 yes FCER2 Olink DEVELOPMENT(v.3511) FCER2 chr19 7688758 7702146 -1 2208 protein_coding 19:7694829 7317 531_2_8 SeqId_3029_52 'DC-SIGN chr19:7772173_C_G$SeqId_3029_52 1 chr19:7772173_C_G rs4804774 cis 19 7772173 C G 0.2446 -0.4199 0.016 1.16e-151 'CD209 antigen ENSG00000090659 'CD209 intergenic_variant ENSG00000090659 ENSG00000090659 'CD209 3 known unspecific_effect -0.39248 0.073146 1.25198752062488e-07 yes CD209 Olink DEVELOPMENT(v.3511) CD209 chr19 7739993 7747564 -1 30835 protein_coding 19:7707287 40277 531_2_9 SeqId_2705_5 'TECK chr19:8121096_A_G$SeqId_2705_5 1 chr19:8121096_A_G rs74959615 cis 19 8121096 A G 0.0769 -1.1806 0.0228 9.19e-585 'C-C motif chemokine 25 ENSG00000131142 'CCL25 missense_variant ENSG00000131142 ENSG00000131142 'CCL25 3 known specific_protein 0.6282 0.10477 3.98107170553497e-09 no CCL25 Olink INFLAMMATION(v.3012) CCL25 chr19 8052318 8062660 1 6370 protein_coding 19:8056212 3894 531_3_3 SeqId_15565_102 'CA125 chr19:8993018_A_G$SeqId_15565_102 1 chr19:8993018_A_G rs61742668 cis 19 8993018 A G 0.1089 -0.26 0.0206 1.93e-36 'Mucin-16 ENSG00000181143 'MUC16 missense_variant ENSG00000181143 ENSG00000181143 'MUC16 3 known specific_protein MUC16 chr19 8848844 8981342 -1 94025 protein_coding 19:8882342 99000 531_4_10 SeqId_18918_86 'PDE4A chr19:10568883_C_G$SeqId_18918_86 1 chr19:10568883_C_G rs145530718 cis 19 10568883 C G 0.0203 1.595 0.0487 5.83e-235 'cAMP-specific 3',5'-cyclic phosphodiesterase 4A ENSG00000065989 'PDE4A intron_variant ENSG00000065989 ENSG00000065989 'PDE4A 3 novel specific_pathway PDE4A chr19 10416773 10469630 1 5141 protein_coding 19:10458207 41434 531_4_6 SeqId_19377_14 'NOE2 chr19:10059160_C_G$SeqId_19377_14 1 chr19:10059160_C_G rs55732232 cis 19 10059160 C G 0.3515 0.8136 0.012 7.58e-1001 'Noelin-2 ENSG00000105088 'OLFM2 regulatory_region_variant ENSG00000105088 ENSG00000105088 'OLFM2 3 known specific_protein OLFM2 chr19 9853718 9936515 -1 93145 protein_coding 19:9948484 11969 531_4_7 SeqId_4342_10 'sICAM-1 chr19:10395683_A_G$SeqId_4342_10 1 chr19:10395683_A_G rs5498 cis 19 10395683 A G 0.5758 1.1941 0.0075 1.82e-5507 'Intercellular adhesion molecule 1 ENSG00000090339 'ICAM1 missense_variant ENSG00000090339 ENSG00000090339|ENSG00000105371 'ICAM1|ICAM4 3 known specific_pathway -0.44824 0.05836 8.85115609830834e-14 no ICAM1 Olink CARDIOMETABOLIC(v.3602) ICAM1 chr19 10271093 10286615 1 3383 protein_coding 19:10285007 13914 531_4_7 SeqId_6550_4 'ICAM4 chr19:10393234_A_G$SeqId_6550_4 1 chr19:10393234_A_G rs5030377 cis 19 10393234 A G 0.6207 0.1152 0.014 1.89e-16 'Intercellular adhesion molecule 4 ENSG00000105371 'ICAM4 intron_variant ENSG00000105371 ENSG00000090339|ENSG00000105371 'ICAM1|ICAM4 3 known specific_pathway ICAM4 chr19 10286955 10288522 1 3386 protein_coding 19:10282558 4397 531_4_8 SeqId_5124_69 'sICAM-5 chr19:10400110_C_G$SeqId_5124_69 1 chr19:10400110_C_G rs281439 cis 19 10400110 C G 0.7742 0.6908 0.0145 2.31e-495 'Intercellular adhesion molecule 5 ENSG00000105376 'ICAM5 upstream_gene_variant 0.179942 rs1056538 ENSG00000105376 'ICAM5 missense_variant ENSG00000105376 ENSG00000105376 'ICAM5 3 known specific_pathway ICAM5 chr19 10289952 10296778 1 7087 protein_coding 19:10289434 518 531_4_8 SeqId_8245_27 'sICAM-5 chr19:10400304_A_G$SeqId_8245_27 1 chr19:10400304_A_G rs281440 cis 19 10400304 A G 0.775 0.8329 0.0143 2.99e-739 'Intercellular adhesion molecule 5 ENSG00000105376 'ICAM5 upstream_gene_variant 0.179492 rs1056538 ENSG00000105376 'ICAM5 missense_variant ENSG00000105376 ENSG00000105376 'ICAM5 3 known specific_pathway ICAM5 chr19 10289952 10296778 1 7087 protein_coding 19:10289628 324 531_5_1 SeqId_5687_5 'GLU2B chr19:11558275_A_G$SeqId_5687_5 1 chr19:11558275_A_G rs11557488 cis 19 11558275 A G 0.2145 0.1177 0.0164 6.08e-13 'Glucosidase 2 subunit beta ENSG00000130175 'PRKCSH missense_variant ENSG00000130175 ENSG00000130175 'PRKCSH 3 novel suggestive_specific_pathway PRKCSH chr19 11435284 11450968 1 5589 protein_coding 19:11447460 12176 531_5_2 SeqId_15566_10 'Calponin-1 chr19:11620979_C_T$SeqId_15566_10 1 chr19:11620979_C_T rs73512794 cis 19 11620979 T C 0.9487 0.3769 0.027 3.57e-44 'Calponin-1 ENSG00000130176 'CNN1 intron_variant ENSG00000130176 ENSG00000130176 'CNN1 3 novel specific_protein CNN1 chr19 11538767 11550323 1 1264 protein_coding 19:11510164 28603 531_5_3 SeqId_3232_28 'TrATPase chr19:11690847_A_G$SeqId_3232_28 1 chr19:11690847_A_G rs111931834 cis 19 11690847 A G 0.1264 0.3761 0.0188 2.57e-89 'Tartrate-resistant acid phosphatase type 5 ENSG00000102575 'ACP5 upstream_gene_variant ENSG00000102575 ENSG00000102575 'ACP5 3 known specific_protein 0.42742 0.08997 2.67670185562589e-06 yes TR-AP Olink CARDIOVASCULAR III(v.6112) ACP5 chr19 11574660 11579008 -1 54 protein_coding 19:11580032 1024 531_5_6 SeqId_19258_24 'GCDH chr19:13010520_A_G$SeqId_19258_24 1 chr19:13010520_A_G rs8012 cis 19 13010520 A G 0.453 -0.1465 0.0127 6.71e-31 'Glutaryl-CoA dehydrogenase, mitochondrial ENSG00000105607 'GCDH 3_prime_UTR_variant ENSG00000105607 ENSG00000105607 'GCDH 3 novel suggestive_specific_pathway GCDH chr19 12891160 12914207 1 2639 protein_coding 19:12899706 8546 531_6_1 SeqId_5132_71 'TCCR chr19:14153293_C_T$SeqId_5132_71 1 chr19:14153293_C_T rs35026308 cis 19 14153293 T C 0.8238 0.7826 0.0157 4.47e-542 'Interleukin-27 receptor subunit alpha ENSG00000104998 'IL27RA missense_variant ENSG00000104998 ENSG00000104998 'IL27RA 3 known specific_protein IL27RA chr19 14031762 14053218 1 9466 protein_coding 19:14042481 10719 531_7_3 SeqId_4546_27 'EMR2 chr19:14505748_C_G$SeqId_4546_27 1 chr19:14505748_C_G rs12973667 cis 19 14505748 C G 0.7254 -0.3617 0.0147 5.84e-134 'Adhesion G protein-coupled receptor E2 ENSG00000127507 'EMR2 intron_variant ENSG00000127507 ENSG00000127507 'ADGRE2 3 known specific_protein -0.11132 0.073242 0.129181403900306 no ADGRE2 Olink METABOLISM(v.3402) ADGRE2 chr19 14732392 14778560 -1 30817 protein_coding 19:14394936 383624 531_7_6 SeqId_5601_2 'PGRP-L chr19:15585945_A_G$SeqId_5601_2 1 chr19:15585945_A_G rs10164310 cis 19 15585945 A G 0.1629 -0.5286 0.0177 6.49e-195 'N-acetylmuramoyl-L-alanine amidase ENSG00000161031 'PGLYRP2 intron_variant 0.311194 rs892145 ENSG00000161031 'PGLYRP2 missense_variant ENSG00000161031 ENSG00000161031 'PGLYRP2 3 known suggestive_specific_pathway PGLYRP2 chr19 15468645 15498956 -1 114770 protein_coding 19:15475134 23822 532_1_2 SeqId_17799_9 '6PGL chr19:17617565_D_I$SeqId_17799_9 1 chr19:17617565_D_I rs548225961 cis 19 17617565 D I 0.4555 0.0872 0.0126 5.21e-12 '6-phosphogluconolactonase ENSG00000130313 'PGLS upstream_gene_variant ENSG00000130313 ENSG00000130313 'PGLS 3 novel specific_protein PGLS chr19 17511636 17521288 1 25796 protein_coding 19:17506757 4879 532_1_3 SeqId_5638_23 'GT251 chr19:17668133_C_T$SeqId_5638_23 1 chr19:17668133_C_T rs4808666 cis 19 17668133 T C 0.4546 -0.1832 0.0127 7.6e-47 'Procollagen galactosyltransferase 1 ENSG00000130309 'COLGALT1 intron_variant ENSG00000130309 ENSG00000130309 'COLGALT1 3 novel specific_protein COLGALT1 chr19 17555649 17583162 1 79709 protein_coding 19:17557324 1675 532_1_4 SeqId_2632_5 'IL-12 Rb1 chr19:18182437_D_I$SeqId_2632_5 1 chr19:18182437_D_I rs10695405 cis 19 18182437 D I 0.6797 0.1414 0.0143 5.74e-23 'Interleukin-12 receptor subunit beta-1 ENSG00000096996 'IL12RB1 intron_variant 0.514004 rs393548 ENSG00000096996 'IL12RB1 splice_acceptor_variant ENSG00000096996 ENSG00000096996 'IL12RB1 3 known specific_protein 0.55647 0.061096 2.21309470960563e-18 yes IL12RB1 Olink IMMUNE RESPONSE(v.3202) IL12RB1 chr19 18058995 18098944 -1 3594 protein_coding 19:18071628 27316 532_2_2 SeqId_4374_45 'MIC-1 chr19:18495908_A_G$SeqId_4374_45 1 chr19:18495908_A_G rs75347775 cis 19 18495908 A G 0.2452 0.3944 0.014 3.21e-175 'Growth/differentiation factor 15 ENSG00000130513 'GDF15 upstream_gene_variant 0.980614 rs1058587 ENSG00000130513 'GDF15 missense_variant ENSG00000130513 ENSG00000130513 'GDF15 3 known specific_protein -0.040391 0.0595 0.497565202364905 no GDF-15 Olink CARDIOVASCULAR III(v.6112) GDF15 chr19 18374731 18389176 1 9518 protein_coding 19:18385098 10367 532_2_3 SeqId_14747_9 'CRLF1 chr19:18721492_A_G$SeqId_14747_9 1 chr19:18721492_A_G rs4808828 cis 19 18721492 A G 0.2009 0.2576 0.0165 1.03e-54 'Cytokine receptor-like factor 1 ENSG00000006016 'CRLF1 intron_variant 0.975407 rs34503316 ENSG00000006016 'CRLF1 inframe_insertion ENSG00000006016 ENSG00000006016 'CRLF1 3 known specific_protein CRLF1 chr19 18572220 18607741 -1 9244 protein_coding 19:18610682 2941 532_2_4 SeqId_8043_153 'COMP chr19:18906548_A_G$SeqId_8043_153 1 chr19:18906548_A_G rs12974746 cis 19 18906548 A G 0.9708 0.4862 0.0425 2.78e-30 'Cartilage oligomeric matrix protein ENSG00000105664 'COMP upstream_gene_variant ENSG00000105664 ENSG00000105664 'COMP 3 novel specific_protein 0.63691 0.1648 0.000126415404894858 yes COMP Olink CARDIOMETABOLIC(v.3602) COMP chr19 18782773 18791305 -1 1311 protein_coding 19:18795739 4434 532_2_5 SeqId_15573_110 'CSPG3 chr19:19329924_C_T$SeqId_15573_110 1 chr19:19329924_C_T rs2228603 cis 19 19329924 T C 0.0781 -0.2873 0.0233 7.07e-35 'Neurocan core protein ENSG00000130287 'NCAN missense_variant ENSG00000130287 ENSG00000130287 'NCAN 3 known unspecific_effect -0.32057 0.11101 0.00405508535448384 yes NCAN Olink NEUROLOGY(v.8011) NCAN chr19 19211958 19252233 1 1463 protein_coding 19:19219115 7157 532_2_6 SeqId_6455_52 'HPLN4 chr19:19368264_A_G$SeqId_6455_52 1 chr19:19368264_A_G rs55765017 cis 19 19368264 A G 0.162 0.1555 0.0184 3.15e-17 'Hyaluronan and proteoglycan link protein 4 ENSG00000187664 'HAPLN4 3_prime_UTR_variant ENSG00000187664 ENSG00000187664 'HAPLN4 3 known specific_protein HAPLN4 chr19 19254756 19262804 -1 404037 protein_coding 19:19257455 5349 535_1_2 SeqId_12517_52 'TFAR19 chr19:33073431_A_G$SeqId_12517_52 1 chr19:33073431_A_G rs4499344 cis 19 33073431 A G 0.3036 0.3901 0.0137 1.91e-178 'Programmed cell death protein 5 ENSG00000105185 'PDCD5 intron_variant 0.493728 rs259290 ENSG00000186326 'RGS9BP missense_variant ENSG00000105185 ENSG00000105185 'PDCD5 5 known suggestive_specific_pathway PDCD5 chr19 32581190 32587453 1 9141 protein_coding 19:32582525 1335 535_1_4 SeqId_12445_50 'ANR27 chr19:33112707_C_T$SeqId_12445_50 1 chr19:33112707_C_T rs12151311 cis 19 33112707 T C 0.3576 -0.1618 0.0137 4.61e-32 'Ankyrin repeat domain-containing protein 27 ENSG00000105186 'ANKRD27 intron_variant 0.740862 rs2287669 ENSG00000105186 'ANKRD27 missense_variant ENSG00000105186 ENSG00000105186 'ANKRD27 3 known suggestive_specific_pathway ANKRD27 chr19 32597006 32676597 -1 84079 protein_coding 19:32621801 54796 536_1_3 SeqId_7244_16 'TM149 chr19:36232420_C_T$SeqId_7244_16 1 chr19:36232420_C_T rs2871921 cis 19 36232420 T C 0.153 -0.601 0.0168 1.38e-278 'IGF-like family receptor 1 ENSG00000126246 'IGFLR1 intron_variant ENSG00000126246 ENSG00000126246 'IGFLR1 3 known specific_protein IGFLR1 chr19 35738801 35742453 -1 79713 protein_coding 19:35741519 934 536_2_1 SeqId_17686_27 'TBCB chr19:36605875_G_T$SeqId_17686_27 1 chr19:36605875_G_T rs2231569 cis 19 36605875 T G 0.0422 0.244 0.0346 1.63e-12 'Tubulin-folding cofactor B ENSG00000105254 'TBCB 5_prime_UTR_variant ENSG00000105254 ENSG00000105254 'TBCB 3 novel specific_protein TBCB chr19 36114289 36125947 1 1155 protein_coding 19:36114973 684 537_2_1 SeqId_2843_13 'SPINT2 chr19:38791841_A_G$SeqId_2843_13 1 chr19:38791841_A_G rs71354995 cis 19 38791841 A G 0.7494 0.8668 0.0127 3.34e-1014 'Kunitz-type protease inhibitor 2 ENSG00000167642 'SPINT2 upstream_gene_variant 0.116106 rs11548457 ENSG00000167642 'SPINT2 missense_variant ENSG00000167642 ENSG00000167641|ENSG00000167642 'PPP1R14A|SPINT2 3 known unspecific_effect 0.22051 0.072635 0.00252813347983411 yes SPINT2 Olink DEVELOPMENT(v.3511) SPINT2 chr19 38244035 38292615 1 10653 protein_coding 19:38301201 57166 537_2_1 SeqId_19117_3 'PP14A chr19:38787965_A_G$SeqId_19117_3 1 chr19:38787965_A_G rs4803999 cis 19 38787965 A G 0.7139 0.3945 0.0139 1.81e-178 'Protein phosphatase 1 regulatory subunit 14A ENSG00000167641 'PPP1R14A downstream_gene_variant ENSG00000167641 ENSG00000167641|ENSG00000167642 'PPP1R14A|SPINT2 3 known unspecific_effect PPP1R14A chr19 38251237 38256532 -1 94274 protein_coding 19:38297325 40793 537_2_2 SeqId_12662_82 'ECH1 chr19:39307103_C_T$SeqId_12662_82 1 chr19:39307103_C_T rs2229259 cis 19 39307103 T C 0.1053 0.7184 0.02 1.39e-282 'Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial ENSG00000104823 'ECH1 missense_variant ENSG00000104823 ENSG00000104823 'ECH1 7 known specific_pathway ECH1 chr19 38815422 38831841 -1 1891 protein_coding 19:38816463 15378 537_2_4 SeqId_2982_82 'Galectin-4 chr19:39205613_C_T$SeqId_2982_82 1 chr19:39205613_C_T rs883394 cis 19 39205613 T C 0.4784 -0.0985 0.0127 1.1e-14 'Galectin-4 ENSG00000171747 'LGALS4 intron_variant ENSG00000171747 ENSG00000171747 'LGALS4 3 known unspecific_effect LGALS4 chr19 38801671 38812945 -1 3960 protein_coding 19:38714973 97972 537_2_5 SeqId_12348_46 'SYSM chr19:39421388_A_G$SeqId_12348_46 1 chr19:39421388_A_G rs730078 cis 19 39421388 A G 0.3813 0.2787 0.0128 7.02e-105 'Serine--tRNA ligase, mitochondrial ENSG00000104835 'SARS2 5_prime_UTR_variant ENSG00000104835 ENSG00000104835 'SARS2 3 novel specific_protein SARS2 chr19 38915266 38930763 -1 54938 protein_coding 19:38930748 15 538_1_1 SeqId_10948_14 'PLD3 chr19:40862872_G_T$SeqId_10948_14 1 chr19:40862872_G_T rs12151243 cis 19 40862872 T G 0.1501 -0.1327 0.0178 8.9e-14 'Phospholipase D3 ENSG00000105223 'PLD3 intron_variant ENSG00000105223 ENSG00000105223 'PLD3 3 novel specific_protein PLD3 chr19 40348456 40380439 1 23646 protein_coding 19:40356965 8509 538_2_1 SeqId_9297_12 'B3GN8 chr19:41932275_C_T$SeqId_9297_12 1 chr19:41932275_C_T rs284662 cis 19 41932275 T C 0.3804 -0.6752 0.0117 9.10e-726 'UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8 ENSG00000177191 'B3GNT8 missense_variant ENSG00000177191 ENSG00000177191 'B3GNT8 8 known unspecific_effect B3GNT8 chr19 41425359 41428730 -1 374907 protein_coding 19:41426370 2360 538_2_2 SeqId_2687_2 'MIA chr19:41283365_C_G$SeqId_2687_2 1 chr19:41283365_C_G rs2233159 cis 19 41283365 C G 0.0713 1.3981 0.0222 7.27e-864 'Melanoma-derived growth regulatory protein ENSG00000261857 'MIA 3_prime_UTR_variant ENSG00000261857 ENSG00000261857 'MIA 3 known suggestive_specific_pathway 1.2338 0.12043 2.03704207770572e-22 yes MIA Olink ONCOLOGY II(v.7002) MIA chr19 40771648 40777490 1 8190 protein_coding 19:40777460 5812 538_3_2 SeqId_5651_50 'PSG7 chr19:43439694_A_G$SeqId_5651_50 1 chr19:43439694_A_G rs113247044 cis 19 43439694 A G 0.8338 -0.2225 0.018 3.43e-35 'Putative pregnancy-specific beta-1-glycoprotein 7 ENSG00000221878 'PSG7 stop_lost ENSG00000221878 ENSG00000221878 'PSG7 3 known suggestive_specific_pathway PSG7 chr19 42924132 42937207 -1 5676 protein_coding 19:42935542 1665 538_3_3 SeqId_9314_9 'PSG5 chr19:43636186_D_I$SeqId_9314_9 1 chr19:43636186_D_I rs36137756 cis 19 43636186 D I 0.6576 -0.4552 0.0139 8.54e-235 'Pregnancy-specific beta-1-glycoprotein 5 ENSG00000204941 'PSG5 intergenic_variant 0.193043 rs17856402 ENSG00000204941 'PSG5 missense_variant ENSG00000204941 ENSG00000204941 'PSG5 3 known specific_pathway PSG5 chr19 43166256 43186536 -1 5673 protein_coding 19:43132035 54501 538_3_5 SeqId_6444_15 'PSG3 chr19:43679088_A_G$SeqId_6444_15 1 chr19:43679088_A_G rs2355433 cis 19 43679088 A G 0.4595 0.7281 0.0119 1.60e-815 'Pregnancy-specific beta-1-glycoprotein 3 ENSG00000221826 'PSG3 intron_variant ENSG00000221826 ENSG00000221826 'PSG3 3 known suggestive_specific_pathway PSG3 chr19 42721638 42740481 -1 5671 protein_coding 19:43174936 434455 538_3_6 SeqId_5649_83 'PSG4 chr19:43710045_C_T$SeqId_5649_83 1 chr19:43710045_C_T rs12978398 cis 19 43710045 T C 0.3993 0.7395 0.0122 1.94e-800 'Pregnancy-specific beta-1-glycoprotein 4 ENSG00000243137 'PSG4 upstream_gene_variant 0.861598 rs1058718 ENSG00000243137 'PSG4 missense_variant ENSG00000243137 ENSG00000243137 'PSG4 3 known suggestive_specific_pathway PSG4 chr19 43192702 43207299 -1 5672 protein_coding 19:43205893 1406 538_3_7 SeqId_9335_28 'PSG9 chr19:43815234_A_G$SeqId_9335_28 1 chr19:43815234_A_G rs28836541 cis 19 43815234 A G 0.2385 0.2002 0.0155 6.24e-38 'Pregnancy-specific beta-1-glycoprotein 9 ENSG00000183668 'PSG9 intergenic_variant ENSG00000183668 ENSG00000183668 'PSG9 3 known suggestive_specific_pathway PSG9 chr19 43211791 43269530 -1 5678 protein_coding 19:43311082 41552 538_3_8 SeqId_13116_25 'CD177 chr19:43826203_C_T$SeqId_13116_25 1 chr19:43826203_C_T rs79338083 cis 19 43826203 T C 0.0179 1.7704 0.0503 7.72e-272 'CD177 antigen ENSG00000204936 'CD177 intergenic_variant ENSG00000204936 ENSG00000204936 'CD177 3 known unspecific_effect 1.694 0.27851 2.40879588172571e-09 yes CD177 Olink DEVELOPMENT(v.3511) CD177 chr19 43353686 43363172 1 57126 protein_coding 19:43322051 31635 538_4_1 SeqId_2652_15 'suPAR chr19:44156472_C_T$SeqId_2652_15 1 chr19:44156472_C_T rs2302524 cis 19 44156472 T C 0.8321 0.249 0.0162 2.88e-53 'Urokinase plasminogen activator surface receptor ENSG00000011422 'PLAUR missense_variant ENSG00000011422 ENSG00000011422 'PLAUR 8 known unspecific_effect 0.25578 0.078996 0.00128706357625333 yes U-PAR Olink CARDIOVASCULAR III(v.6112) PLAUR chr19 43646095 43670547 -1 5329 protein_coding 19:43652320 18227 538_4_2 SeqId_13107_9 'LYPD3 chr19:43992228_C_G$SeqId_13107_9 1 chr19:43992228_C_G rs35107209 cis 19 43992228 C G 0.782 -0.1923 0.0161 4.79e-33 'Ly6/PLAUR domain-containing protein 3 ENSG00000124466 'LYPD3 intron_variant ENSG00000124466 ENSG00000124466 'LYPD3 3 novel specific_protein -0.47544 0.074198 3.51965422524766e-10 yes LYPD3 Olink ONCOLOGY II(v.7002) LYPD3 chr19 43460787 43465608 -1 27076 protein_coding 19:43488076 22468 538_5_1 SeqId_9314_9 'PSG5 chr19:45411941_C_T$SeqId_9314_9 1 chr19:45411941_C_T rs429358 trans 19 45411941 T C 0.8489 0.422 0.0187 1.48e-112 'Pregnancy-specific beta-1-glycoprotein 5 ENSG00000204941 'PSG5 missense_variant ENSG00000130203 ENSG00000130203 'APOE 4 known unspecific_effect PSG5 chr19 43166256 43186536 -1 5673 protein_coding 19:44908684 1722148 538_5_10 SeqId_3714_49 'CK-MB chr19:45821183_C_T$SeqId_3714_49 1 chr19:45821183_C_T rs11559024 cis 19 45821183 T C 0.9799 0.6905 0.045 4.35e-53 'Creatine kinase M-type:Creatine kinase B-type heterodimer ENSG00000104879|ENSG00000166165 'CKM|CKB missense_variant ENSG00000104879|ENSG00000166165 ENSG00000104879|ENSG00000166165 'CKB|CKM 3 known specific_protein CKM chr19 45306413 45322875 -1 1158 protein_coding 19:45317925 4950 538_5_2 SeqId_12500_88 'SAE2 chr19:45413233_G_T$SeqId_12500_88 1 chr19:45413233_G_T rs1065853 trans 19 45413233 T G 0.0851 0.198 0.0243 3.55e-16 'SUMO-activating enzyme subunit 2 ENSG00000126261 'UBA2 upstream_gene_variant 0.980195 rs7412 ENSG00000130203 'APOE missense_variant ENSG00000130203 ENSG00000130203 'APOE 5 known unspecific_effect UBA2 chr19 34428352 34471251 1 10054 protein_coding 19:44909976 10481624 538_5_5 SeqId_14685_17 'PKB beta chr19:45417638_D_I$SeqId_14685_17 1 chr19:45417638_D_I rs34954997 trans 19 45417638 D I 0.764 0.2104 0.0156 2.5e-41 'RAC-beta serine/threonine-protein kinase ENSG00000105221 'AKT2 5_prime_UTR_variant 0.538923 rs429358 ENSG00000130203 'APOE missense_variant ENSG00000130208|ENSG00000069399|ENSG00000104856|ENSG00000130202 ENSG00000130203 'APOE 5 known unspecific_effect AKT2 chr19 40230317 40285536 -1 208 protein_coding 19:44914382 4628846 538_5_5 SeqId_5963_9 'Dermokine chr19:45416741_C_T$SeqId_5963_9 1 chr19:45416741_C_T rs438811 trans 19 45416741 T C 0.2376 0.3364 0.0147 5.43e-116 'Dermokine ENSG00000161249 'DMKN upstream_gene_variant 0.541733 rs429358 ENSG00000130203 'APOE missense_variant ENSG00000130208 ENSG00000130203 'APOE 5 known unspecific_effect DMKN chr19 35497220 35513658 -1 93099 protein_coding 19:44913484 9399826 538_5_5 SeqId_2418_55 'Apo E chr19:45416178_G_T$SeqId_2418_55 1 chr19:45416178_G_T rs483082 cis 19 45416178 T G 0.2365 -0.3477 0.0157 7.21e-109 'Apolipoprotein E ENSG00000130203 'APOE upstream_gene_variant 0.541792 rs429358 ENSG00000130203 'APOE missense_variant ENSG00000130203 ENSG00000130203 'APOE 5 known unspecific_effect APOE chr19 44905791 44909393 1 348 protein_coding 19:44912921 7130 538_5_6 SeqId_14093_10 'Flt3 ligand chr19:45448465_G_T$SeqId_14093_10 1 chr19:45448465_G_T rs5167 trans 19 45448465 T G 0.6523 -0.1496 0.0139 3.45e-27 'Fms-related tyrosine kinase 3 ligand ENSG00000090554 'FLT3LG missense_variant ENSG00000267467 ENSG00000267467 'APOC4 3 known unspecific_effect FLT3LG chr19 49474207 49486231 1 2323 protein_coding 19:44945208 4528999 538_5_7 SeqId_15364_101 'Apo C-I chr19:45430280_C_G$SeqId_15364_101 1 chr19:45430280_C_G rs5112 cis 19 45430280 C G 0.4627 -0.289 0.0141 1.17e-93 'Apolipoprotein C-I ENSG00000130208 'APOC1 non_coding_transcript_exon_variant ENSG00000130208 ENSG00000130208 'APOC1 5 known unspecific_effect APOC1 chr19 44914247 44919349 1 341 protein_coding 19:44927023 12776 538_5_8 SeqId_9386_42 'TTC9B chr19:44932972_C_T$SeqId_9386_42 1 chr19:44932972_C_T rs1434579 trans 19 44932972 T C 0.3457 0.3376 0.0138 1.02e-132 'Tetratricopeptide repeat protein 9B ENSG00000174521 'TTC9B missense_variant ENSG00000167383 ENSG00000167383 ' 3 novel specific_protein TTC9B chr19 40216058 40218384 -1 148014 protein_coding 19:44428797 4210413 538_5_9 SeqId_2816_50 'BCAM chr19:45335996_A_G$SeqId_2816_50 1 chr19:45335996_A_G rs563366239 cis 19 45335996 A G 0.9896 -0.9704 0.0688 3.16e-45 'Basal Cell Adhesion Molecule ENSG00000187244 'BCAM intergenic_variant 0.631909 rs28399656 ENSG00000187244 'BCAM missense_variant ENSG00000187244 ENSG00000187244 'BCAM 3 known specific_protein 0.30706 0.32869 0.350671119646478 no BCAM Olink DEVELOPMENT(v.3511) BCAM chr19 44809071 44821421 1 4059 protein_coding 19:44832739 23668 538_6_1 SeqId_8866_53 'QPCTL chr19:46206262_A_G$SeqId_8866_53 1 chr19:46206262_A_G rs17850756 cis 19 46206262 A G 0.3311 -0.2622 0.0132 7.3e-88 'Glutaminyl-peptide cyclotransferase-like protein ENSG00000011478 'QPCTL synonymous_variant ENSG00000011478 ENSG00000011478 'QPCTL 3 known specific_protein QPCTL chr19 45692403 45703989 1 54814 protein_coding 19:45703004 10601 538_6_3 SeqId_3329_14 'PGRP-S chr19:46528004_A_G$SeqId_3329_14 1 chr19:46528004_A_G rs12462367 cis 19 46528004 A G 0.3216 -0.1976 0.015 1.03e-39 'Peptidoglycan recognition protein 1 ENSG00000008438 'PGLYRP1 upstream_gene_variant ENSG00000008438 ENSG00000008438 'PGLYRP1 3 known specific_protein PGLYRP1 chr19 46019153 46023053 -1 8993 protein_coding 19:46024746 1693 539_1_1 SeqId_4548_4 'Fucosyltransferase 3 chr19:49206172_C_T$SeqId_4548_4 1 chr19:49206172_C_T rs516246 trans 19 49206172 T C 0.4869 -0.1072 0.0137 5.93e-15 'Galactoside 3(4)-L-fucosyltransferase ENSG00000171124 'FUT3 intron_variant 0.997554 rs601338 ENSG00000176920 'FUT2 stop_gained ENSG00000176920 ENSG00000176920 'FUT2 5 known unspecific_effect FUT3 chr19 5842888 5851471 -1 2525 protein_coding 19:48702915 42851444 539_1_1 SeqId_15565_102 'CA125 chr19:49206985_A_G$SeqId_15565_102 1 chr19:49206985_A_G rs602662 trans 19 49206985 A G 0.5133 0.0975 0.0129 4.63e-14 'Mucin-16 ENSG00000181143 'MUC16 missense_variant ENSG00000176920 ENSG00000176920 'FUT2 5 known unspecific_effect MUC16 chr19 8848844 8981342 -1 94025 protein_coding 19:48703728 39722386 539_1_1 SeqId_2705_5 'TECK chr19:49214274_A_G$SeqId_2705_5 1 chr19:49214274_A_G rs281379 trans 19 49214274 A G 0.5017 -0.0937 0.0135 4.1e-12 'C-C motif chemokine 25 ENSG00000131142 'CCL25 downstream_gene_variant 0.850593 rs601338 ENSG00000176920 'FUT2 stop_gained ENSG00000176920 ENSG00000176920 'FUT2 5 known unspecific_effect CCL25 chr19 8052318 8062660 1 6370 protein_coding 19:48711017 40658699 539_1_2 SeqId_2742_68 'Siglec-7 chr19:47761543_C_T$SeqId_2742_68 1 chr19:47761543_C_T rs2302985 trans 19 47761543 T C 0.577 0.1083 0.0137 2.43e-15 'Sialic acid-binding Ig-like lectin 7 ENSG00000168995 'SIGLEC7 intron_variant 0.178961 rs138370983 ENSG00000105321 'CCDC9 inframe_insertion none none ' novel specific_protein SIGLEC7 chr19 51142299 51153526 1 27036 protein_coding 19:47258286 3884013 539_1_3 SeqId_18310_26 'SELW chr19:48269947_A_G$SeqId_18310_26 1 chr19:48269947_A_G rs12608475 cis 19 48269947 A G 0.5195 0.1427 0.0132 2.0e-27 'Selenoprotein W ENSG00000178980 'SEPW1 intron_variant,non_coding_transcript_variant ENSG00000178980 ENSG00000178980 'SELENOW 3 novel specific_protein SELENOW chr19 47778677 47784686 1 6415 protein_coding 19:47766690 11987 539_1_4 SeqId_9829_91 'SULT 2A1 chr19:48389002_A_T$SeqId_9829_91 1 chr19:48389002_A_T rs212099 cis 19 48389002 A T 0.1662 -0.2469 0.0176 1.29e-44 'Bile salt sulfotransferase ENSG00000105398 'SULT2A1 intron_variant ENSG00000105398 ENSG00000105398 'SULT2A1 3 known specific_protein -0.39742 0.083457 2.53921806988671e-06 yes SULT2A1 Olink CELL REGULATION(v.3701) SULT2A1 chr19 47870467 47886315 -1 6822 protein_coding 19:47885745 570 539_1_5 SeqId_8859_51 'CAH11 chr19:49115440_C_T$SeqId_8859_51 1 chr19:49115440_C_T rs425879 cis 19 49115440 T C 0.141 0.1735 0.0183 2.31e-21 'Carbonic anhydrase-related protein 11 ENSG00000063180 'CA11 intron_variant ENSG00000063180 ENSG00000063180 'CA11 3 known unspecific_effect CA11 chr19 48637946 48646187 -1 770 protein_coding 19:48612183 34004 539_1_6 SeqId_4468_21 'SPHK2 chr19:49127490_C_T$SeqId_4468_21 1 chr19:49127490_C_T rs386243 cis 19 49127490 T C 0.2518 0.1545 0.0156 3.47e-23 'Sphingosine kinase 2 ENSG00000063176 'SPHK2 intron_variant ENSG00000063176 ENSG00000063176 'SPHK2 3 known unspecific_effect SPHK2 chr19 48619291 48630717 1 56848 protein_coding 19:48624233 4942 539_2_1 SeqId_4500_50 'SCGF-alpha chr19:51230733_C_T$SeqId_4500_50 1 chr19:51230733_C_T rs116924815 cis 19 51230733 T C 0.028 1.1391 0.0401 1.37e-177 'Stem cell growth factor-alpha ENSG00000105472 'CLEC11A downstream_gene_variant ENSG00000105472 ENSG00000105472 'CLEC11A 3 known unspecific_effect 0.81164 0.17625 5.27594184726995e-06 yes CLEC11A Olink DEVELOPMENT(v.3511) CLEC11A chr19 50723364 50725708 1 6320 protein_coding 19:50727476 4112 539_2_1 SeqId_2966_65 'SCGF-beta chr19:51230733_C_T$SeqId_2966_65 1 chr19:51230733_C_T rs116924815 cis 19 51230733 T C 0.028 1.0465 0.0403 8.67e-149 'Stem cell growth factor-beta ENSG00000105472 'CLEC11A downstream_gene_variant ENSG00000105472 ENSG00000105472 'CLEC11A 3 known unspecific_effect 0.81164 0.17625 5.27594184726995e-06 yes CLEC11A Olink DEVELOPMENT(v.3511) CLEC11A chr19 50723364 50725708 1 6320 protein_coding 19:50727476 4112 539_2_10 SeqId_3378_49 'Kallikrein 7 chr19:51485622_A_G$SeqId_3378_49 1 chr19:51485622_A_G rs2659067 cis 19 51485622 A G 0.0897 -0.6029 0.0228 5.37e-154 'Kallikrein-7 ENSG00000169035 'KLK7 synonymous_variant ENSG00000169035 ENSG00000169035 'KLK7 3 known suggestive_specific_pathway KLK7 chr19 50976468 50984099 -1 5650 protein_coding 19:50982366 1733 539_2_11 SeqId_2834_54 'kallikrein 8 chr19:51504808_A_G$SeqId_2834_54 1 chr19:51504808_A_G rs74705037 cis 19 51504808 A G 0.0449 0.8468 0.0325 4.2e-150 'Kallikrein-8 ENSG00000129455 'KLK8 5_prime_UTR_variant ENSG00000129455 ENSG00000129455 'KLK8 3 known suggestive_specific_pathway 0.96095 0.15816 2.50841852825238e-09 yes hK8 Olink ONCOLOGY II(v.7002) KLK8 chr19 50996007 51002711 -1 11202 protein_coding 19:51001552 1159 539_2_12 SeqId_6227_1 'kallikrein 10 chr19:51523203_C_T$SeqId_6227_1 1 chr19:51523203_C_T rs2569454 cis 19 51523203 T C 0.4295 -0.4965 0.0128 3.94e-329 'Kallikrein-10 ENSG00000129451 'KLK10 5_prime_UTR_variant 0.777228 rs3745535 ENSG00000129451 'KLK10 missense_variant ENSG00000129451 ENSG00000129451 'KLK10 3 known unspecific_effect -0.62583 0.058209 2.56448403651771e-24 yes KLK10 Olink METABOLISM(v.3402) KLK10 chr19 51012739 51020175 -1 5655 protein_coding 19:51019947 228 539_2_13 SeqId_2831_29 'Kallikrein 11 chr19:51527364_A_G$SeqId_2831_29 1 chr19:51527364_A_G rs1048328 cis 19 51527364 A G 0.0801 -1.4455 0.0209 2.20e-1041 'Kallikrein-11 ENSG00000167757 'KLK11 missense_variant ENSG00000167757 ENSG00000167757 'KLK11 3 known specific_protein -0.47071 0.12074 0.000110458718398863 yes hK11 Olink ONCOLOGY II(v.7002) KLK11 chr19 51022216 51028039 -1 11012 protein_coding 19:51024108 3931 539_2_2 SeqId_8376_25 'LSHB chr19:49520214_C_T$SeqId_8376_25 1 chr19:49520214_C_T rs144948359 cis 19 49520214 T C 0.9194 0.4073 0.0235 2.31e-67 'Lutropin subunit beta ENSG00000104826 'LHB intron_variant 0.99636 rs1800447 ENSG00000104826 'LHB missense_variant ENSG00000104826 ENSG00000104826|ENSG00000104827|ENSG00000135346|ENSG00000189052|ENSG00000196337|ENSG00000213030 'CGA|CGB3|CGB5|CGB7|CGB8|LHB 3 known specific_pathway 0.086329 0.11926 0.469504760377732 no LHB Olink ORGAN DAMAGE(v.3301) LHB chr19 49015980 49017091 -1 3972 protein_coding 19:49016957 134 539_2_2 SeqId_2953_31 'Luteinizing hormone chr19:49521014_A_C$SeqId_2953_31 1 chr19:49521014_A_C rs3795052 cis 19 49521014 A C 0.9191 0.5991 0.0205 2.21e-187 'Luteinizing hormone ENSG00000135346|ENSG00000104826 'CGA|LHB upstream_gene_variant 0.989463 rs1800447 ENSG00000104826 'LHB missense_variant ENSG00000135346|ENSG00000104826 ENSG00000104826|ENSG00000104827|ENSG00000135346|ENSG00000189052|ENSG00000196337|ENSG00000213030 'CGA|CGB3|CGB5|CGB7|CGB8|LHB 3 known specific_pathway LHB chr19 49015980 49017091 -1 3972 protein_coding 19:49017757 666 539_2_3 SeqId_19365_11 'BCAT2 chr19:49309776_C_G$SeqId_19365_11 1 chr19:49309776_C_G rs117048185 cis 19 49309776 C G 0.0183 -0.6947 0.0495 8.75e-45 'Branched-chain-amino-acid aminotransferase, mitochondrial ENSG00000105552 'BCAT2 missense_variant,splice_region_variant ENSG00000105552 ENSG00000105552 'BCAT2 3 novel specific_protein BCAT2 chr19 48795062 48811029 -1 587 protein_coding 19:48806519 4510 539_2_4 SeqId_13972_4 'DHB14 chr19:49318380_A_G$SeqId_13972_4 1 chr19:49318380_A_G rs35299026 cis 19 49318380 A G 0.0477 -0.3197 0.0323 4.48e-23 '17-beta-hydroxysteroid dehydrogenase 14 ENSG00000087076 'HSD17B14 missense_variant ENSG00000087076 ENSG00000087076 'HSD17B14 3 novel specific_protein HSD17B14 chr19 48813018 48836510 -1 51171 protein_coding 19:48815123 21387 539_2_5 SeqId_10451_11 'NUCB1 chr19:49402593_D_I$SeqId_10451_11 1 chr19:49402593_D_I rs113587416 cis 19 49402593 D I 0.1223 -0.2096 0.021 1.95e-23 'Nucleobindin-1 ENSG00000104805 'NUCB1 upstream_gene_variant ENSG00000104805 ENSG00000104805 'NUCB1 3 novel specific_protein NUCB1 chr19 48900312 48923372 1 4924 protein_coding 19:48899337 975 539_2_6 SeqId_16309_30 'Soggy-1 chr19:49857214_D_I$SeqId_16309_30 1 chr19:49857214_D_I rs77121881 cis 19 49857214 D I 0.281 -0.1027 0.015 7.51e-12 'Dickkopf-like protein 1 ENSG00000104901 'DKKL1 intron_variant 0.893349 rs1054770 ENSG00000104901 'DKKL1 missense_variant ENSG00000104901 ENSG00000104901 'DKKL1 3 novel specific_protein -1.049 0.046635 3.87257644921612e-77 yes DKKL1 Olink CELL REGULATION(v.3701) DKKL1 chr19 49361783 49375116 1 27120 protein_coding 19:49353958 7825 539_2_7 SeqId_17151_84 'IRF-3 chr19:50195771_G_T$SeqId_17151_84 1 chr19:50195771_G_T rs10423580 cis 19 50195771 T G 0.5705 0.1045 0.013 1.16e-15 'Interferon regulatory factor 3 ENSG00000126456 'IRF3 intron_variant 0.277773 rs7251 ENSG00000126456 'IRF3 missense_variant ENSG00000126456 ENSG00000126456 'IRF3 3 novel specific_protein IRF3 chr19 49659569 49665875 -1 3661 protein_coding 19:49692514 26639 539_2_8 SeqId_13657_2 'PNKP chr19:50370846_D_I$SeqId_13657_2 1 chr19:50370846_D_I rs3739164 cis 19 50370846 D I 0.4313 -0.1348 0.0129 9.9e-26 'Bifunctional polynucleotide phosphatase/kinase ENSG00000039650 'PNKP upstream_gene_variant ENSG00000039650 ENSG00000039650 'PNKP 3 novel specific_protein PNKP chr19 49859882 49878351 -1 11284 protein_coding 19:49867590 10761 539_2_9 SeqId_8468_19 'PSA chr19:51349090_A_G$SeqId_8468_19 1 chr19:51349090_A_G rs266849 cis 19 51349090 A G 0.8005 0.0806 0.0107 5.0e-14 'Prostate-specific antigen ENSG00000142515 'KLK3 intron_variant 0.1257 rs17632542 ENSG00000142515 'KLK3 missense_variant ENSG00000142515 ENSG00000142515 'KLK3 3 novel specific_protein KLK3 chr19 50854915 50860764 1 354 protein_coding 19:50845834 9081 539_3_10 SeqId_10037_98 'SIG12 chr19:52004074_C_T$SeqId_10037_98 1 chr19:52004074_C_T 19:52004074_C_T cis 19 52004074 T C 0.8404 -1.2604 0.0142 1.49e-1713 'Sialic acid-binding Ig-like lectin 12 ENSG00000254521 'SIGLEC12 intron_variant 0.359914 rs66949844 ENSG00000254521 'SIGLEC12 frameshift_variant ENSG00000254521 ENSG00000254521 'SIGLEC12 3 known suggestive_specific_pathway SIGLEC12 chr19 51491227 51501800 -1 89858 protein_coding 19:51500820 980 539_3_11 SeqId_2741_22 'Siglec-6 chr19:52032668_C_T$SeqId_2741_22 1 chr19:52032668_C_T rs4146202 cis 19 52032668 T C 0.4044 0.6128 0.0124 7.50e-533 'Sialic acid-binding Ig-like lectin 6 ENSG00000105492 'SIGLEC6 intron_variant ENSG00000105492 ENSG00000105492 'SIGLEC6 3 known suggestive_specific_pathway -0.011703 0.062932 0.852550277313544 no SIGLEC6 Olink CELL REGULATION(v.3701) SIGLEC6 chr19 51517819 51531856 -1 946 protein_coding 19:51529414 2442 539_3_3 SeqId_16792_4 'Siglec-5 chr19:52130638_A_C$SeqId_16792_4 1 chr19:52130638_A_C rs872629 cis 19 52130638 A C 0.1166 -1.1339 0.0183 2.66e-836 'Sialic acid-binding Ig-like lectin 5 ENSG00000105501 'SIGLEC5 intron_variant ENSG00000105501 ENSG00000105501 'SIGLEC5 7 known suggestive_specific_pathway SIGLEC5 chr19 51611927 51645545 -1 8778 protein_coding 19:51627385 18160 539_3_3 SeqId_8248_222 'SIG14 chr19:52130638_A_C$SeqId_8248_222 1 chr19:52130638_A_C rs872629 cis 19 52130638 A C 0.1166 -1.1393 0.0182 1.54e-853 'Sialic acid-binding Ig-like lectin 14 ENSG00000254415 'SIGLEC14 intron_variant ENSG00000254415 ENSG00000105501 'SIGLEC5 7 known suggestive_specific_pathway SIGLEC14 chr19 51639478 51646825 -1 100049587 protein_coding 19:51627385 19440 539_3_3 SeqId_9275_2 'Siglec-5 chr19:52130638_A_C$SeqId_9275_2 1 chr19:52130638_A_C rs872629 none 19 52130638 A C 0.1166 -1.1745 0.0181 5.74e-917 'Sialic acid-binding Ig-like lectin 5 intron_variant ENSG00000105501 ENSG00000105501 'SIGLEC5 7 known suggestive_specific_pathway SIGLEC5 chr19 51611927 51645545 -1 8778 protein_coding 19:51627385 18160 539_3_4 SeqId_3007_7 'Siglec-9 chr19:51628529_A_G$SeqId_3007_7 1 chr19:51628529_A_G rs2075803 cis 19 51628529 A G 0.4413 1.1729 0.0077 1.97e-5041 'Sialic acid-binding Ig-like lectin 9 ENSG00000129450 'SIGLEC9 missense_variant ENSG00000129450 ENSG00000129450 'SIGLEC9 7 known suggestive_specific_pathway 0.54742 0.059178 7.37904230129098e-19 yes Siglec-9 Olink NEUROLOGY(v.8011) SIGLEC9 chr19 51124906 51136651 1 27180 protein_coding 19:51125272 366 539_3_5 SeqId_3199_54 'kallikrein 12 chr19:51535460_D_I$SeqId_3199_54 1 chr19:51535460_D_I rs10635364 cis 19 51535460 D I 0.4089 0.123 0.014 1.51e-18 'Kallikrein-12 ENSG00000186474 'KLK12 intron_variant 0.988784 rs3745540 ENSG00000186474 'KLK12 splice_donor_variant ENSG00000186474 ENSG00000186474 'KLK12 3 known unspecific_effect KLK12 chr19 51029092 51035230 -1 43849 protein_coding 19:51032205 3025 539_3_6 SeqId_11152_46 'kallikrein 13 chr19:51539433_C_T$SeqId_11152_46 1 chr19:51539433_C_T rs2569459 cis 19 51539433 T C 0.353 -0.4004 0.0136 3.49e-189 'Kallikrein-13 ENSG00000167759 'KLK13 upstream_gene_variant ENSG00000167759 ENSG00000167759 'KLK13 3 known suggestive_specific_pathway -0.51358 0.061044 4.56036915951297e-16 yes KLK13 Olink ONCOLOGY II(v.7002) KLK13 chr19 51055626 51065114 -1 26085 protein_coding 19:51036176 28938 539_3_7 SeqId_15544_25 'kallikrein 14 chr19:51584410_A_G$SeqId_15544_25 1 chr19:51584410_A_G rs17658926 cis 19 51584410 A G 0.1903 0.2282 0.0162 7.53e-45 'Kallikrein-14 ENSG00000129437 'KLK14 intron_variant 0.490431 rs2569491 ENSG00000129437 'KLK14 missense_variant ENSG00000129437 ENSG00000129437 'KLK14 3 known specific_pathway KLK14 chr19 51077495 51084245 -1 43847 protein_coding 19:51081153 3092 539_3_8 SeqId_2742_68 'Siglec-7 chr19:51646140_C_G$SeqId_2742_68 1 chr19:51646140_C_G rs140185670 cis 19 51646140 C G 0.0651 -0.6772 0.0283 1.33e-126 'Sialic acid-binding Ig-like lectin 7 ENSG00000168995 'SIGLEC7 intron_variant ENSG00000168995 ENSG00000168995 'SIGLEC7 3 known specific_pathway -0.44553 0.12339 0.000337287308658869 yes SIGLEC7 Olink METABOLISM(v.3402) SIGLEC7 chr19 51142299 51153526 1 27036 protein_coding 19:51142883 584 539_3_9 SeqId_3166_92 'Siglec-3 chr19:51728477_C_T$SeqId_3166_92 1 chr19:51728477_C_T rs12459419 cis 19 51728477 T C 0.3268 -0.9373 0.0108 2.59e-1638 'Myeloid cell surface antigen CD33 ENSG00000105383 'CD33 missense_variant ENSG00000105383 ENSG00000105383 'CD33 3 known suggestive_specific_pathway -0.90343 0.052802 1.13501081567231e-51 yes CD33 Olink NEURO EXPLORATORY(v.3901) CD33 chr19 51225064 51243860 1 945 protein_coding 19:51225221 157 54_2_1 SeqId_18218_48 'CB032 chr2:68579931_A_G$SeqId_18218_48 1 chr2:68579931_A_G rs7578047 cis 2 68579931 A G 0.8682 0.6311 0.0189 2.62e-243 'CB1 cannabinoid receptor-interacting protein 1 ENSG00000119865 'CNRIP1 regulatory_region_variant ENSG00000119865 ENSG00000119865 'CNRIP1 3 novel specific_protein CNRIP1 chr2 68284171 68320051 -1 25927 protein_coding 2:68352799 32748 54_2_2 SeqId_7875_86 'PLEK chr2:68619981_A_C$SeqId_7875_86 1 chr2:68619981_A_C rs1867312 cis 2 68619981 A C 0.5659 0.1251 0.0132 3.25e-21 'Pleckstrin ENSG00000115956 'PLEK intron_variant 0.521472 rs1063479 ENSG00000115956 'PLEK missense_variant ENSG00000115956 ENSG00000115956 'PLEK 3 novel suggestive_specific_pathway PLEK chr2 68365282 68397453 1 5341 protein_coding 2:68392849 27567 54_2_4 SeqId_11333_82 'RHG25 chr2:68996668_A_G$SeqId_11333_82 1 chr2:68996668_A_G rs13413887 cis 2 68996668 A G 0.2355 -0.2748 0.0146 2.39e-79 'Rho GTPase-activating protein 25 ENSG00000163219 'ARHGAP25 intron_variant ENSG00000163219 ENSG00000163219 'ARHGAP25 3 known specific_protein ARHGAP25 chr2 68679601 68826833 1 9938 protein_coding 2:68769536 89935 54_3_1 SeqId_6416_8 'GKN2 chr2:69177269_A_C$SeqId_6416_8 1 chr2:69177269_A_C rs62133344 cis 2 69177269 A C 0.0554 -0.9891 0.0273 9.38e-288 'Gastrokine-2 ENSG00000183607 'GKN2 missense_variant ENSG00000183607 ENSG00000183607 'GKN2 8 known suggestive_specific_pathway GKN2 chr2 68945232 68952893 -1 200504 protein_coding 2:68950137 2756 54_3_2 SeqId_18166_4 'RHOB chr2:70488470_C_T$SeqId_18166_4 1 chr2:70488470_C_T rs2706762 trans 2 70488470 T C 0.1498 -0.2246 0.0187 4.0e-33 'Rho-related GTP-binding protein RhoB ENSG00000143878 'RHOB missense_variant ENSG00000116005 ENSG00000116005 'PCYOX1 6 known suggestive_specific_pathway RHOB chr2 20447074 20449440 1 388 protein_coding 2:70261338 49814264 54_3_2 SeqId_6431_68 'PCYOX chr2:70488470_C_T$SeqId_6431_68 1 chr2:70488470_C_T rs2706762 cis 2 70488470 T C 0.1499 -0.9549 0.0168 4.06e-704 'Prenylcysteine oxidase 1 ENSG00000116005 'PCYOX1 missense_variant ENSG00000116005 ENSG00000116005 'PCYOX1 6 known suggestive_specific_pathway PCYOX1 chr2 70257386 70281185 1 51449 protein_coding 2:70261338 3952 54_3_3 SeqId_7770_25 'NFU1 chr2:69650730_A_G$SeqId_7770_25 1 chr2:69650730_A_G rs74637005 cis 2 69650730 A G 0.035 -0.7657 0.035 5.95e-106 'NFU1 iron-sulfur cluster scaffold homolog, mitochondrial ENSG00000169599 'NFU1 missense_variant ENSG00000169599 ENSG00000169599 'NFU1 3 novel specific_protein NFU1 chr2 69396113 69437628 -1 27247 protein_coding 2:69423598 14030 54_3_4 SeqId_17164_15 'annexin IV chr2:70033584_C_T$SeqId_17164_15 1 chr2:70033584_C_T rs2228203 cis 2 70033584 T C 0.1925 -0.3889 0.0154 5.37e-140 'Annexin A4 ENSG00000196975 'ANXA4 missense_variant ENSG00000196975 ENSG00000196975 'ANXA4 3 novel suggestive_specific_pathway 0.1958 0.078766 0.0132617244509738 no ANXA4 Olink METABOLISM(v.3402) ANXA4 chr2 69644425 69827112 1 307 protein_coding 2:69806452 162027 54_4_1 SeqId_3894_15 'NAGK chr2:71302992_A_T$SeqId_3894_15 1 chr2:71302992_A_T rs1861853 cis 2 71302992 A T 0.2392 0.1742 0.0142 1.23e-34 'N-acetyl-D-glucosamine kinase ENSG00000124357 'NAGK intron_variant ENSG00000124357 ENSG00000124357 'NAGK 3 known suggestive_specific_pathway NAGK chr2 71064344 71079808 1 55577 protein_coding 2:71075862 11518 54_4_2 SeqId_9388_18 'MCEE chr2:71345964_G_T$SeqId_9388_18 1 chr2:71345964_G_T rs6740268 cis 2 71345964 T G 0.8237 0.2214 0.0165 5.93e-41 'Methylmalonyl-CoA epimerase, mitochondrial ENSG00000124370 'MCEE intron_variant 0.994696 rs6748672 ENSG00000124370 'MCEE missense_variant ENSG00000124370 ENSG00000124370 'MCEE 3 novel suggestive_specific_pathway MCEE chr2 71109684 71130239 -1 84693 protein_coding 2:71118834 11405 540_1_1 SeqId_7015_8 'LIRB5 chr19:54759361_C_T$SeqId_7015_8 1 chr19:54759361_C_T rs12975366 cis 19 54759361 T C 0.6005 1.1468 0.0088 1.03e-3690 'Leukocyte immunoglobulin-like receptor subfamily B member 5 ENSG00000105609 'LILRB5 missense_variant ENSG00000105609 ENSG00000105609 'LILRB5 6 known unspecific_effect 1.1198 0.037002 1.07151930523761e-113 yes LILRB5 Olink CARDIOMETABOLIC(v.3602) LILRB5 chr19 54249421 54257301 -1 10990 protein_coding 19:54255498 1803 540_1_1 SeqId_3378_49 'Kallikrein 7 chr19:54759361_C_T$SeqId_3378_49 1 chr19:54759361_C_T rs12975366 trans 19 54759361 T C 0.5998 0.1526 0.0143 1.14e-26 'Kallikrein-7 ENSG00000169035 'KLK7 missense_variant ENSG00000105609 ENSG00000105609 'LILRB5 6 known unspecific_effect KLK7 chr19 50976468 50984099 -1 5650 protein_coding 19:54255498 3271399 540_1_10 SeqId_15614_168 'LIRA2 chr19:55105666_G_T$SeqId_15614_168 1 chr19:55105666_G_T rs28635090 cis 19 55105666 T G 0.1016 -0.5121 0.0212 1.75e-128 'Leukocyte immunoglobulin-like receptor subfamily A member 2 ENSG00000239998 'LILRA2 5_prime_UTR_variant 0.885011 rs7249811 ENSG00000239998 'LILRA2 missense_variant ENSG00000239998 ENSG00000239998 'LILRA2 3 known specific_pathway LILRA2 chr19 54572920 54590287 1 11027 protein_coding 19:54594201 21281 540_1_11 SeqId_5090_49 'ILT-2 chr19:55143839_A_T$SeqId_5090_49 1 chr19:55143839_A_T rs10426886 cis 19 55143839 A T 0.05 -1.7987 0.0255 4.33e-1083 'Leukocyte immunoglobulin-like receptor subfamily B member 1 ENSG00000104972 'LILRB1 intron_variant 0.961786 rs61739171 ENSG00000104972 'LILRB1 missense_variant ENSG00000104972 ENSG00000104972 'LILRB1 3 known specific_protein -0.12642 0.14443 0.381829958255869 no LILRB1 Olink CARDIOMETABOLIC(v.3602) LILRB1 chr19 54617158 54638022 1 10859 protein_coding 19:54632388 15230 540_1_12 SeqId_17153_46 'KI2L3 chr19:55248107_G_T$SeqId_17153_46 1 chr19:55248107_G_T rs17207383 cis 19 55248107 T G 0.3748 0.5373 0.0136 2.37e-341 'Killer cell immunoglobulin-like receptor 2DL3 ENSG00000243772 'KIR2DL3 upstream_gene_variant 0.584929 19:55263898_G_A ENSG00000243772 'KIR2DL3 missense_variant ENSG00000243772 ENSG00000243772 'KIR2DL3 3 novel specific_pathway 0.47248 0.059843 1.9543394557754e-14 yes KIR2DL3 Olink NEURO EXPLORATORY(v.3901) KIR2DL3 chr19 54738513 54753052 1 3804 protein_coding 19:54736640 1873 540_1_15 SeqId_5095_21 'KI2L4 chr19:55377583_C_T$SeqId_5095_21 1 chr19:55377583_C_T rs3745900 cis 19 55377583 T C 0.2338 0.3166 0.0154 1.93e-93 'Killer cell immunoglobulin-like receptor 2DL4 ENSG00000189013 'KIR2DL4 intron_variant 0.10171 rs1051456 ENSG00000189013 'KIR2DL4 missense_variant ENSG00000189013 ENSG00000189013 'KIR2DL4 3 known suggestive_specific_pathway KIR2DL4 chr19 54803611 54814517 1 3805 protein_coding 19:54866128 62517 540_1_16 SeqId_8360_169 'NKp46 chr19:55418054_A_C$SeqId_8360_169 1 chr19:55418054_A_C rs2278428 cis 19 55418054 A C 0.9203 0.4545 0.0247 1.67e-75 'Natural cytotoxicity triggering receptor 1 ENSG00000189430 'NCR1 missense_variant ENSG00000189430 ENSG00000189430 'NCR1 3 known unspecific_effect NCR1 chr19 54906148 54916140 1 9437 protein_coding 19:54906696 548 540_1_17 SeqId_3194_36 'GPVI chr19:55538980_C_T$SeqId_3194_36 1 chr19:55538980_C_T rs1654425 cis 19 55538980 T C 0.165 -0.4047 0.0162 2.67e-137 'Platelet glycoprotein VI ENSG00000088053 'GP6 synonymous_variant 0.997583 rs1613662 ENSG00000088053 'GP6 missense_variant ENSG00000088053 ENSG00000088053 'GP6 3 known specific_protein -0.36377 0.081644 1.0406387653975e-05 yes GP6 Olink CARDIOVASCULAR III(v.6112) GP6 chr19 55013705 55038264 -1 51206 protein_coding 19:55027612 10652 540_1_2 SeqId_3714_49 'CK-MB chr19:54759666_C_T$SeqId_3714_49 1 chr19:54759666_C_T rs10405357 trans 19 54759666 T C 0.558 0.1477 0.0129 2.72e-30 'Creatine kinase M-type:Creatine kinase B-type heterodimer ENSG00000104879|ENSG00000166165 'CKM|CKB intron_variant 0.690162 rs12975366 ENSG00000105609 'LILRB5 missense_variant none none ' known unspecific_effect CKM chr19 45306413 45322875 -1 1158 protein_coding 19:54255803 8932928 540_1_4 SeqId_7787_25 'LIRA5 chr19:54813762_C_T$SeqId_7787_25 1 chr19:54813762_C_T rs651279 cis 19 54813762 T C 0.6816 0.437 0.0136 2.08e-227 'Leukocyte immunoglobulin-like receptor subfamily A member 5 ENSG00000187116 'LILRA5 downstream_gene_variant ENSG00000187116 ENSG00000187116 'LILRA5 3 known suggestive_specific_pathway 0.40362 0.064954 1.11712044465683e-09 yes LILRA5 Olink METABOLISM(v.3402) LILRA5 chr19 54307070 54313166 -1 353514 protein_coding 19:54302487 10679 540_1_4 SeqId_8766_29 'LIRA5 chr19:54813762_C_T$SeqId_8766_29 1 chr19:54813762_C_T rs651279 cis 19 54813762 T C 0.6816 0.3555 0.0131 5.33e-161 'Leukocyte immunoglobulin-like receptor subfamily A member 5 ENSG00000187116 'LILRA5 downstream_gene_variant ENSG00000187116 ENSG00000187116 'LILRA5 3 known suggestive_specific_pathway 0.40362 0.064954 1.11712044465683e-09 yes LILRA5 Olink METABOLISM(v.3402) LILRA5 chr19 54307070 54313166 -1 353514 protein_coding 19:54302487 10679 540_1_5 SeqId_15615_8 'LIRB3 chr19:54720896_A_G$SeqId_15615_8 1 chr19:54720896_A_G rs3745410 cis 19 54720896 A G 0.9404 -1.421 0.0291 2.63e-520 'Leukocyte immunoglobulin-like receptor subfamily B member 3 ENSG00000204577 'LILRB3 3_prime_UTR_variant ENSG00000204577 ENSG00000204577 'LILRB3 3 novel suggestive_specific_pathway LILRB3 chr19 54216278 54223506 -1 11025 protein_coding 19:54217027 6479 540_1_6 SeqId_7059_14 'LIRA6 chr19:54748396_C_T$SeqId_7059_14 1 chr19:54748396_C_T rs34810796 cis 19 54748396 T C 0.9099 -1.3001 0.0209 7.00e-843 'Leukocyte immunoglobulin-like receptor subfamily A member 6 ENSG00000244482 'LILRA6 upstream_gene_variant 0.436467 rs199826565 ENSG00000244482 'LILRA6 missense_variant ENSG00000244482 ENSG00000244482 'LILRA6 3 known suggestive_specific_pathway LILRA6 chr19 54236592 54242791 -1 79168 protein_coding 19:54244555 1764 540_1_7 SeqId_5091_28 'ILT-4 chr19:54784936_C_T$SeqId_5091_28 1 chr19:54784936_C_T rs448092 cis 19 54784936 T C 0.1913 -1.1344 0.0132 1.62e-1606 'Leukocyte immunoglobulin-like receptor subfamily B member 2 ENSG00000131042 'LILRB2 5_prime_UTR_variant 0.99821 rs383369 ENSG00000131042 'LILRB2 missense_variant ENSG00000131042 ENSG00000131042 'LILRB2 3 known suggestive_specific_pathway -0.90596 0.073128 8.26037949577182e-31 yes LILRB2 Olink CARDIOMETABOLIC(v.3602) LILRB2 chr19 54273812 54281184 -1 10288 protein_coding 19:54281081 103 540_1_9 SeqId_8299_66 'LIRA4 chr19:54849942_A_G$SeqId_8299_66 1 chr19:54849942_A_G rs2241384 cis 19 54849942 A G 0.1706 -0.5177 0.0172 2.66e-198 'Leukocyte immunoglobulin-like receptor subfamily A member 4 ENSG00000239961 'LILRA4 missense_variant ENSG00000239961 ENSG00000239961 'LILRA4 3 known specific_protein LILRA4 chr19 54333185 54339162 -1 23547 protein_coding 19:54338671 491 540_2_2 SeqId_10442_1 'TM190 chr19:55888095_C_T$SeqId_10442_1 1 chr19:55888095_C_T rs4806666 cis 19 55888095 T C 0.4514 -1.0261 0.0096 1.19e-2483 'Transmembrane protein 190 ENSG00000160472 'TMEM190 upstream_gene_variant ENSG00000160472 ENSG00000160472 'TMEM190 3 known specific_protein TMEM190 chr19 55376826 55378246 1 147744 protein_coding 19:55376727 99 541_1_1 SeqId_16561_9 'Alpha-1B-glycoprotein chr19:58864479_C_T$SeqId_16561_9 1 chr19:58864479_C_T rs893184 cis 19 58864479 T C 0.0519 -1.0714 0.0279 1.78e-322 'Alpha-1B-glycoprotein ENSG00000121410 'A1BG missense_variant ENSG00000121410 ENSG00000121410 'A1BG 3 novel specific_protein A1BG chr19 58345178 58353492 -1 1 protein_coding 19:58353113 379 542_1_1 SeqId_8464_31 'RSPO4 chr20:943837_C_T$SeqId_8464_31 1 chr20:943837_C_T rs75904281 cis 20 943837 T C 0.0169 -0.4366 0.0524 8.05e-17 'R-spondin-4 ENSG00000101282 'RSPO4 intron_variant ENSG00000101282 ENSG00000101282 'RSPO4 3 novel specific_protein RSPO4 chr20 958452 1002311 -1 343637 protein_coding 20:963194 39117 542_1_2 SeqId_17343_6 'SNPH chr20:1281004_C_T$SeqId_17343_6 1 chr20:1281004_C_T rs3795141 cis 20 1281004 T C 0.654 -0.1791 0.0143 7.35e-36 'Syntaphilin ENSG00000101298 'SNPH intron_variant ENSG00000101298 ENSG00000101298 'SNPH 3 novel specific_protein SNPH chr20 1266280 1309328 1 9751 protein_coding 20:1300360 34080 542_1_3 SeqId_19261_12 'SDCB2 chr20:1323192_C_T$SeqId_19261_12 1 chr20:1323192_C_T rs6109526 cis 20 1323192 T C 0.6581 -0.1015 0.013 6.54e-15 'Syntenin-2 ENSG00000125775 'SDCBP2 intron_variant,non_coding_transcript_variant ENSG00000125775 ENSG00000125775 'SDCBP2 3 novel suggestive_specific_pathway SDCBP2 chr20 1309909 1329139 -1 27111 protein_coding 20:1342548 13409 542_1_4 SeqId_6247_9 'SIRB1 chr20:1539165_C_T$SeqId_6247_9 1 chr20:1539165_C_T rs12480515 cis 20 1539165 T C 0.2614 0.8837 0.0128 1.13e-1037 'Signal-regulatory protein beta-1 ENSG00000101307 'SIRPB1 5_prime_UTR_variant 0.280542 rs41275422 ENSG00000101307 'SIRPB1 missense_variant ENSG00000101307 ENSG00000101307 'SIRPB1 3 known specific_protein 0.49497 0.06825 1.63681652142781e-12 yes SIRPB1 Olink DEVELOPMENT(v.3511) SIRPB1 chr20 1561385 1620061 -1 10326 protein_coding 20:1558519 61542 542_1_5 SeqId_9241_40 'SIRPG chr20:1616206_A_G$SeqId_9241_40 1 chr20:1616206_A_G rs6043409 cis 20 1616206 A G 0.3462 -0.3443 0.0141 4.01e-132 'Signal-regulatory protein gamma ENSG00000089012 'SIRPG missense_variant ENSG00000089012 ENSG00000089012 'SIRPG 3 known specific_pathway SIRPG chr20 1629152 1657779 -1 55423 protein_coding 20:1635560 22219 542_1_6 SeqId_5430_66 'SHPS1 chr20:1893121_A_G$SeqId_5430_66 1 chr20:1893121_A_G rs1569960 cis 20 1893121 A G 0.3786 -1.1951 0.0078 1.06e-5100 'Tyrosine-protein phosphatase non-receptor type substrate 1 ENSG00000198053 'SIRPA intron_variant 0.878187 rs139878822 ENSG00000198053 'SIRPA inframe_insertion ENSG00000198053 ENSG00000198053 'SIRPA 3 known specific_protein -1.0549 0.040304 1.14551294144553e-94 yes SHPS-1 Olink CARDIOVASCULAR III(v.6112) SIRPA chr20 1894167 1940592 1 140885 protein_coding 20:1912475 18308 542_1_8 SeqId_4471_50 'TGM3 chr20:2321105_C_G$SeqId_4471_50 1 chr20:2321105_C_G rs214830 cis 20 2321105 C G 0.6351 0.2446 0.014 2.86e-68 'Protein-glutamine gamma-glutamyltransferase E ENSG00000125780 'TGM3 missense_variant ENSG00000125780 ENSG00000125780 'TGM3 3 novel specific_protein TGM3 chr20 2296001 2341079 1 7053 protein_coding 20:2340459 44458 542_2_1 SeqId_4464_10 'Sialoadhesin chr20:3695977_A_G$SeqId_4464_10 1 chr20:3695977_A_G rs181210490 cis 20 3695977 A G 0.0122 -0.5652 0.0626 1.75e-19 'Sialoadhesin ENSG00000088827 'SIGLEC1 intergenic_variant 0.836807 rs150358287 ENSG00000088827 'SIGLEC1 stop_gained ENSG00000088827 ENSG00000088827 'SIGLEC1 6 known unspecific_effect SIGLEC1 chr20 3686970 3712600 -1 6614 protein_coding 20:3715330 2730 542_2_3 SeqId_6255_74 'CPXM1 chr20:2783771_A_G$SeqId_6255_74 1 chr20:2783771_A_G rs13043754 cis 20 2783771 A G 0.886 0.6483 0.0197 6.44e-238 'Probable carboxypeptidase X1 ENSG00000088882 'CPXM1 upstream_gene_variant ENSG00000088882 ENSG00000088882 'CPXM1 3 known specific_protein 0.49462 0.09564 3.40721861659357e-07 yes CPXM1 Olink CELL REGULATION(v.3701) CPXM1 chr20 2794074 2800627 -1 56265 protein_coding 20:2803125 2498 542_2_4 SeqId_10708_3 'GON2 chr20:3023181_A_G$SeqId_10708_3 1 chr20:3023181_A_G rs3761244 cis 20 3023181 A G 0.8445 0.3496 0.0183 1.62e-81 'Progonadoliberin-2 ENSG00000125787 'GNRH2 upstream_gene_variant 0.686424 rs16996832 ENSG00000125787 'GNRH2 frameshift_variant ENSG00000125787 ENSG00000125787 'GNRH2 3 known specific_pathway GNRH2 chr20 3043622 3045747 1 2797 protein_coding 20:3042535 1087 542_2_5 SeqId_8356_88 'NEU1 chr20:3049890_G_T$SeqId_8356_88 1 chr20:3049890_G_T rs877172 cis 20 3049890 T G 0.6863 -0.4227 0.016 2.17e-154 'Oxytocin-neurophysin 1 ENSG00000101405 'OXT upstream_gene_variant ENSG00000101405 ENSG00000101405 'OXT 3 known specific_protein OXT chr20 3071620 3072517 1 5020 protein_coding 20:3069244 2376 542_2_6 SeqId_18916_25 'Inosine triphosphatase chr20:3193842_A_C$SeqId_18916_25 1 chr20:3193842_A_C rs1127354 cis 20 3193842 A C 0.075 -1.5112 0.0206 2.77e-1171 'Inosine triphosphate pyrophosphatase ENSG00000125877 'ITPA missense_variant ENSG00000125877 ENSG00000125877 'ITPA 3 novel suggestive_specific_pathway ITPA chr20 3208868 3223870 1 3704 protein_coding 20:3213196 4328 542_2_7 SeqId_15499_11 'Attractin chr20:3562866_A_G$SeqId_15499_11 1 chr20:3562866_A_G rs118065662 cis 20 3562866 A G 0.9873 2.1868 0.057 3.51e-322 'Attractin ENSG00000088812 'ATRN missense_variant ENSG00000088812 ENSG00000088812 'ATRN 3 novel suggestive_specific_pathway ATRN chr20 3471018 3651118 1 8455 protein_coding 20:3582219 111201 543_1_1 SeqId_12786_61 'GDE5 chr20:5573659_A_G$SeqId_12786_61 1 chr20:5573659_A_G rs6085222 cis 20 5573659 A G 0.5395 0.1274 0.0131 1.98e-22 'Glycerophosphocholine phosphodiesterase GPCPD1 ENSG00000125772 'GPCPD1 intron_variant ENSG00000125772 ENSG00000125772 'GPCPD1 3 novel specific_protein GPCPD1 chr20 5544439 5611006 -1 56261 protein_coding 20:5593013 17993 545_1_1 SeqId_13123_3 'FLRT3 chr20:14678135_G_T$SeqId_13123_3 1 chr20:14678135_G_T rs6135225 cis 20 14678135 T G 0.3092 -0.6504 0.0125 1.98e-590 'Leucine-rich repeat transmembrane protein FLRT3 ENSG00000125848 'FLRT3 intron_variant ENSG00000125848 ENSG00000125848 'FLRT3 3 known specific_pathway FLRT3 chr20 14322985 14337614 -1 23767 protein_coding 20:14697489 359875 546_1_2 SeqId_15440_57 'NEC2 chr20:17230025_A_G$SeqId_15440_57 1 chr20:17230025_A_G rs6044697 cis 20 17230025 A G 0.4949 -0.1965 0.0135 7.06e-48 'Neuroendocrine convertase 2 ENSG00000125851 'PCSK2 intron_variant ENSG00000125851 ENSG00000125851 'PCSK2 3 novel specific_protein PCSK2 chr20 17226107 17484578 1 5126 protein_coding 20:17249380 23273 546_2_3 SeqId_19194_9 'Histidyl-tRNA synthetase-related chr20:18571333_C_T$SeqId_19194_9 1 chr20:18571333_C_T rs59832377 cis 20 18571333 T C 0.554 0.2995 0.0126 2.6e-124 'D-tyrosyl-tRNA(Tyr) deacylase 1 ENSG00000125821 'DTD1 intron_variant ENSG00000125821 ENSG00000125821 'DTD1 3 novel specific_protein DTD1 chr20 18587942 18766644 1 92675 protein_coding 20:18590689 2747 547_1_1 SeqId_4324_33 'CYTT chr20:23730336_C_T$SeqId_4324_33 1 chr20:23730336_C_T rs4260306 cis 20 23730336 T C 0.2948 -0.4775 0.0137 4.25e-265 'Cystatin-SA ENSG00000170369 'CST2 intron_variant 0.366762 rs2070856 ENSG00000170373 'CST1 missense_variant ENSG00000170369 ENSG00000170369|ENSG00000170373 'CST1|CST2 3 known specific_pathway CST2 chr20 23823769 23826729 -1 1470 protein_coding 20:23749699 77030 547_1_1 SeqId_5459_33 'CYTN chr20:23730336_C_T$SeqId_5459_33 1 chr20:23730336_C_T rs4260306 cis 20 23730336 T C 0.2948 -0.5493 0.0138 1.81e-346 'Cystatin-SN ENSG00000170373 'CST1 intron_variant 0.366762 rs2070856 ENSG00000170373 'CST1 missense_variant ENSG00000170373 ENSG00000170369|ENSG00000170373 'CST1|CST2 3 known specific_pathway CST1 chr20 23747562 23751268 -1 1469 protein_coding 20:23749699 1569 547_1_2 SeqId_2609_59 'Cystatin C chr20:23612791_A_G$SeqId_2609_59 1 chr20:23612791_A_G rs734801 cis 20 23612791 A G 0.7731 0.4018 0.0152 6.7e-155 'Cystatin-C ENSG00000101439 'CST3 intron_variant 0.954877 rs1064039 ENSG00000101439 'CST3 missense_variant ENSG00000101439 ENSG00000101439 'CST3 7 known suggestive_specific_pathway 0.34999 0.072845 2.072048897759e-06 yes CST3 Olink CARDIOMETABOLIC(v.3602) CST3 chr20 23626706 23638473 -1 1471 protein_coding 20:23632154 6319 547_1_3 SeqId_14076_74 'Cystatin-S chr20:23690467_A_G$SeqId_14076_74 1 chr20:23690467_A_G rs7263473 cis 20 23690467 A G 0.1132 -0.5018 0.0207 4.36e-130 'Cystatin-S ENSG00000101441 'CST4 downstream_gene_variant ENSG00000101441 ENSG00000101441 'CST4 3 known specific_pathway CST4 chr20 23685640 23689038 -1 1472 protein_coding 20:23709830 20792 547_1_4 SeqId_3803_10 'CYTD chr20:23853181_A_C$SeqId_3803_10 1 chr20:23853181_A_C rs4642010 cis 20 23853181 A C 0.185 0.737 0.0154 7.73e-500 'Cystatin-D ENSG00000170367 'CST5 downstream_gene_variant 0.270893 rs1799841 ENSG00000170367 'CST5 missense_variant ENSG00000170367 ENSG00000170367 'CST5 3 known suggestive_specific_pathway 0.80066 0.068877 1.06414301822432e-27 yes CST5 Olink INFLAMMATION(v.3012) CST5 chr20 23875934 23879748 -1 1473 protein_coding 20:23872544 7204 547_2_1 SeqId_3302_58 'CYTF chr20:24911823_C_T$SeqId_3302_58 1 chr20:24911823_C_T rs2151462 cis 20 24911823 T C 0.7754 0.7862 0.0144 7.58e-650 'Cystatin-F ENSG00000077984 'CST7 TF_binding_site_variant ENSG00000077984 ENSG00000077984 'CST7 3 known suggestive_specific_pathway CST7 chr20 24949269 24959928 1 8530 protein_coding 20:24931187 18082 547_2_3 SeqId_10605_22 'APMAP chr20:24978732_D_I$SeqId_10605_22 1 chr20:24978732_D_I rs112085660 cis 20 24978732 D I 0.1232 0.2664 0.0203 1.79e-39 'Adipocyte plasma membrane-associated protein ENSG00000101474 'APMAP regulatory_region_variant ENSG00000101474 ENSG00000101474 'APMAP 3 known suggestive_specific_pathway APMAP chr20 24962925 24992751 -1 57136 protein_coding 20:24998097 5346 547_2_4 SeqId_8932_1 'ENTP6 chr20:25195509_A_G$SeqId_8932_1 1 chr20:25195509_A_G rs6050446 cis 20 25195509 A G 0.031 -0.6378 0.0386 2.95e-61 'Ectonucleoside triphosphate diphosphohydrolase 6 ENSG00000197586 'ENTPD6 missense_variant ENSG00000197586 ENSG00000197586 'ENTPD6 3 novel specific_protein -1.8552 0.16448 2.4099054286866e-26 yes ENTPD6 Olink CELL REGULATION(v.3701) ENTPD6 chr20 25195693 25228075 1 955 protein_coding 20:25214873 19180 547_3_1 SeqId_5634_39 'OFUT1 chr20:26130543_C_T$SeqId_5634_39 1 chr20:26130543_C_T rs149197965 trans 20 26130543 T C 0.0208 -0.4096 0.0492 8.5e-17 'GDP-fucose protein O-fucosyltransferase 1 ENSG00000101346 'POFUT1 intergenic_variant none none ' novel specific_protein POFUT1 chr20 32207880 32238658 1 23509 protein_coding 20:26149907 6057973 548_1_1 SeqId_8932_1 'ENTP6 chr20:29539588_G_T$SeqId_8932_1 1 chr20:29539588_G_T rs187067151 trans 20 29539588 T G 0.0379 -0.4824 0.0376 1.33e-37 'Ectonucleoside triphosphate diphosphohydrolase 6 ENSG00000197586 'ENTPD6 downstream_gene_variant 0.612362 rs6050446 ENSG00000197586 'ENTPD6 missense_variant ENSG00000200325 ENSG00000200325 ' 1 novel suggestive_specific_pathway -1.461 0.17256 3.06902198839116e-16 yes ENTPD6 Olink CELL REGULATION(v.3701) ENTPD6 chr20 25195693 25228075 1 955 protein_coding 20:30304912 5109219 548_1_2 SeqId_3302_58 'CYTF chr20:29627346_C_T$SeqId_3302_58 1 chr20:29627346_C_T rs572910713 trans 20 29627346 T C 0.0108 1.0976 0.0733 9.98e-51 'Cystatin-F ENSG00000077984 'CST7 intron_variant ENSG00000149531 ENSG00000101294|ENSG00000149531|ENSG00000231934 'HM13 1 known specific_protein CST7 chr20 24949269 24959928 1 8530 protein_coding 20:30392670 5443401 548_1_4 SeqId_5634_39 'OFUT1 chr20:30815755_C_T$SeqId_5634_39 1 chr20:30815755_C_T rs76143353 cis 20 30815755 T C 0.0595 -0.9479 0.0268 6.37e-274 'GDP-fucose protein O-fucosyltransferase 1 ENSG00000101346 'POFUT1 intron_variant 0.998025 rs17268666 ENSG00000101346 'POFUT1 missense_variant ENSG00000101346 ENSG00000101346 'POFUT1 3 known specific_protein POFUT1 chr20 32207880 32238658 1 23509 protein_coding 20:32227952 20072 548_2_1 SeqId_15367_38 'LPLC1 chr20:31688868_C_G$SeqId_15367_38 1 chr20:31688868_C_G rs761931 cis 20 31688868 C G 0.588 -0.4341 0.0128 2.45e-250 'BPI fold-containing family B member 1 ENSG00000125999 'BPIFB1 intron_variant ENSG00000125999 ENSG00000125999 'BPIFB1 3 known specific_protein BPIFB1 chr20 33273480 33309871 1 92747 protein_coding 20:33101062 172418 548_3_2 SeqId_5676_54 'ASIP chr20:32819223_D_I$SeqId_5676_54 1 chr20:32819223_D_I rs565102642 cis 20 32819223 D I 0.9144 -0.9654 0.0218 2.55e-428 'Agouti-signaling protein ENSG00000101440 'ASIP intron_variant ENSG00000101440 ENSG00000101440 'ASIP 3 known specific_protein ASIP chr20 34194569 34269344 1 434 protein_coding 20:34231418 36849 548_3_3 SeqId_15526_33 'GSHB chr20:33493877_A_G$SeqId_15526_33 1 chr20:33493877_A_G rs3787215 cis 20 33493877 A G 0.3822 -0.2408 0.0127 1.45e-79 'Glutathione synthetase ENSG00000100983 'GSS intron_variant ENSG00000100983 ENSG00000100983 'GSS 3 novel unspecific_effect GSS chr20 34928432 34956027 -1 2937 protein_coding 20:34906074 49953 548_3_4 SeqId_5346_24 'CPNE1 chr20:34221155_G_T$SeqId_5346_24 1 chr20:34221155_G_T rs6060524 cis 20 34221155 T G 0.1052 -1.2328 0.0183 4.14e-988 'Copine-1 ENSG00000214078 'CPNE1 intron_variant 0.998206 rs147019139 ENSG00000214078 'CPNE1 frameshift_variant ENSG00000214078 ENSG00000214078 'CPNE1 3 known specific_protein CPNE1 chr20 35626031 35664956 -1 8904 protein_coding 20:35633233 31723 548_4_1 SeqId_18312_68 'NDRG3 chr20:35373277_C_T$SeqId_18312_68 1 chr20:35373277_C_T rs111279459 cis 20 35373277 T C 0.9771 -0.578 0.0472 1.73e-34 'Protein NDRG3 ENSG00000101079 'NDRG3 intron_variant ENSG00000101079 ENSG00000101079 'NDRG3 3 novel specific_protein NDRG3 chr20 36651766 36746090 -1 57446 protein_coding 20:36744874 1216 548_4_3 SeqId_18934_50 'Tissue transglutaminase chr20:36800222_G_T$SeqId_18934_50 1 chr20:36800222_G_T rs13044109 cis 20 36800222 T G 0.6237 0.1961 0.0137 3.41e-46 'Protein-glutamine gamma-glutamyltransferase 2 ENSG00000198959 'TGM2 intergenic_variant ENSG00000198959 ENSG00000198959 'TGM2 3 novel specific_protein TGM2 chr20 38127385 38166578 -1 7052 protein_coding 20:38171820 5242 548_5_1 SeqId_3074_6 'LBP chr20:36997655_C_T$SeqId_3074_6 1 chr20:36997655_C_T rs2232613 cis 20 36997655 T C 0.0761 -1.2145 0.0227 3.91e-624 'Lipopolysaccharide-binding protein ENSG00000129988 'LBP missense_variant ENSG00000129988 ENSG00000129988 'LBP 7 known unspecific_effect LBP chr20 38346482 38377013 1 3929 protein_coding 20:38369011 22529 548_5_1 SeqId_9583_17 'RNF24 chr20:36997655_C_T$SeqId_9583_17 1 chr20:36997655_C_T rs2232613 trans 20 36997655 T C 0.0761 -0.7063 0.0244 2.51e-184 'RING finger protein 24 ENSG00000101236 'RNF24 missense_variant ENSG00000129988 ENSG00000129988 'LBP 7 known unspecific_effect RNF24 chr20 3927309 4015558 -1 11237 protein_coding 20:38369011 34353453 548_5_2 SeqId_4126_22 'BPI chr20:36950550_A_G$SeqId_4126_22 1 chr20:36950550_A_G rs6127742 cis 20 36950550 A G 0.1022 -0.6855 0.0211 5.35e-231 'Bactericidal permeability-increasing protein ENSG00000101425 'BPI intron_variant 0.545389 rs5743509 ENSG00000101425 'BPI missense_variant ENSG00000101425 ENSG00000101425 'BPI 3 known unspecific_effect BPI chr20 38304150 38337505 1 671 protein_coding 20:38322148 17998 548_7_1 SeqId_8773_172 'EMIL3 chr20:39990377_C_G$SeqId_8773_172 1 chr20:39990377_C_G rs61739314 cis 20 39990377 C G 0.0333 -0.674 0.0358 5.61e-79 'EMILIN-3 ENSG00000183798 'EMILIN3 missense_variant ENSG00000183798 ENSG00000183798 'EMILIN3 3 known specific_protein EMILIN3 chr20 41359962 41366818 -1 90187 protein_coding 20:41361737 5081 548_7_2 SeqId_4563_61 'PLCG1 chr20:39993463_C_T$SeqId_4563_61 1 chr20:39993463_C_T rs113622480 cis 20 39993463 T C 0.0146 0.4606 0.0573 9.17e-16 '1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 ENSG00000124181 'PLCG1 intron_variant ENSG00000124181 ENSG00000124181 'PLCG1 3 novel specific_protein PLCG1 chr20 41136960 41196801 1 5335 protein_coding 20:41364823 227863 549_1_1 SeqId_15475_4 'PLTP chr20:44551855_C_T$SeqId_15475_4 1 chr20:44551855_C_T rs6073958 cis 20 44551855 T C 0.799 0.7407 0.0154 7.58e-505 'Phospholipid transfer protein ENSG00000100979 'PLTP intergenic_variant 0.213708 rs17576 ENSG00000100985 'MMP9 missense_variant ENSG00000100979 ENSG00000100979 'PLTP 6 known unspecific_effect 0.29352 0.076914 0.000153108746168203 yes PLTP Olink CARDIOMETABOLIC(v.3602) PLTP chr20 45898621 45912155 -1 5360 protein_coding 20:45923216 11061 549_1_10 SeqId_7926_13 'SPIT3 chr20:44141331_A_G$SeqId_7926_13 1 chr20:44141331_A_G rs6032259 cis 20 44141331 A G 0.4709 -0.2571 0.0097 1.38e-155 'Kunitz-type protease inhibitor 3 ENSG00000101446 'SPINT3 missense_variant ENSG00000101446 ENSG00000101446 'SPINT3 3 known suggestive_specific_pathway SPINT3 chr20 45512461 45515622 -1 10816 protein_coding 20:45512691 2931 549_1_11 SeqId_12556_7 'UBE2C chr20:44425026_D_I$SeqId_12556_7 1 chr20:44425026_D_I rs11477536 cis 20 44425026 D I 0.6374 -0.2407 0.0141 2.3e-65 'Ubiquitin-conjugating enzyme E2 C ENSG00000175063 'UBE2C intron_variant ENSG00000175063 ENSG00000175063 'UBE2C 3 known unspecific_effect UBE2C chr20 45812576 45816957 1 11065 protein_coding 20:45796388 16188 549_1_12 SeqId_17400_71 'ACOT8 chr20:44472163_C_T$SeqId_17400_71 1 chr20:44472163_C_T rs55931834 cis 20 44472163 T C 0.4272 0.1056 0.013 5.17e-16 'Acyl-coenzyme A thioesterase 8 ENSG00000101473 'ACOT8 splice_region_variant,intron_variant ENSG00000101473 ENSG00000101473 'ACOT8 3 known unspecific_effect ACOT8 chr20 45841721 45857405 -1 10005 protein_coding 20:45843524 13881 549_1_13 SeqId_2579_17 'MMP-9 chr20:44629290_A_T$SeqId_2579_17 1 chr20:44629290_A_T rs6094237 cis 20 44629290 A T 0.604 -0.1069 0.0135 2.25e-15 'Matrix metalloproteinase-9 ENSG00000100985 'MMP9 regulatory_region_variant 0.80636 rs17576 ENSG00000100985 'MMP9 missense_variant ENSG00000100985 ENSG00000100985 'MMP9 3 known unspecific_effect MMP9 chr20 46008908 46016561 1 4318 protein_coding 20:46000651 8257 549_1_2 SeqId_6392_7 'WISP-2 chr20:43322002_C_G$SeqId_6392_7 1 chr20:43322002_C_G rs6065746 cis 20 43322002 C G 0.5687 0.2458 0.0135 2.53e-74 'WNT1-inducible-signaling pathway protein 2 ENSG00000064205 'WISP2 intron_variant,non_coding_transcript_variant ENSG00000064205 ENSG00000064205 'CCN5 3 novel specific_protein CCN5 chr20 44714844 44728509 1 8839 protein_coding 20:44693361 21483 549_1_3 SeqId_14156_33 '14-3-3 protein beta/alpha chr20:43528521_A_G$SeqId_14156_33 1 chr20:43528521_A_G rs6017444 cis 20 43528521 A G 0.2731 -0.1509 0.0138 1.11e-27 '14-3-3 protein beta/alpha ENSG00000166913 'YWHAB intron_variant ENSG00000166913 ENSG00000166913 'YWHAB 3 known suggestive_specific_pathway YWHAB chr20 44885702 44908532 1 7529 protein_coding 20:44899880 14178 549_1_5 SeqId_4413_3 'SLPI chr20:43736533_G_T$SeqId_4413_3 1 chr20:43736533_G_T rs916311 cis 20 43736533 T G 0.337 -0.1637 0.0142 1.23e-30 'Antileukoproteinase ENSG00000124107 'SLPI downstream_gene_variant ENSG00000124107 ENSG00000124107 'SLPI 3 known suggestive_specific_pathway SLPI chr20 45252239 45254564 -1 6590 protein_coding 20:45107892 146672 549_1_6 SeqId_4982_54 'Elafin chr20:43787352_D_I$SeqId_4982_54 1 chr20:43787352_D_I rs35615384 cis 20 43787352 D I 0.1776 0.4067 0.0169 2.78e-127 'Elafin ENSG00000124102 'PI3 intergenic_variant 0.994671 rs17333103 ENSG00000124102 'PI3 missense_variant ENSG00000124102 ENSG00000124102 'PI3 3 known suggestive_specific_pathway 0.28456 0.077259 0.000256389361022429 yes PI3 Olink CARDIOVASCULAR III(v.6112) PI3 chr20 45174902 45176544 1 5266 protein_coding 20:45158712 16190 549_1_7 SeqId_7083_74 'MATN4 chr20:43925427_A_G$SeqId_7083_74 1 chr20:43925427_A_G rs11086958 cis 20 43925427 A G 0.2507 -0.232 0.0151 4.05e-53 'Matrilin-4 ENSG00000124159 'MATN4 intron_variant 0.999405 rs2227275 ENSG00000124159 'MATN4 missense_variant ENSG00000124159 ENSG00000124159 'MATN4 3 known unspecific_effect MATN4 chr20 45293445 45308529 -1 8785 protein_coding 20:45296787 11742 55_1_1 SeqId_5980_55 'BOLA3 chr2:74371995_A_G$SeqId_5980_55 1 chr2:74371995_A_G rs828889 cis 2 74371995 A G 0.4199 -0.1856 0.0125 8.75e-50 'BolA-like protein 3 ENSG00000163170 'BOLA3 intron_variant ENSG00000163170 ENSG00000163170 'BOLA3 3 novel unspecific_effect BOLA3 chr2 74135400 74147912 -1 388962 protein_coding 2:74144868 3044 55_1_2 SeqId_18321_38 'MTDC chr2:74416240_A_G$SeqId_18321_38 1 chr2:74416240_A_G rs12469365 cis 2 74416240 A G 0.4925 -0.1272 0.0127 1.08e-23 'Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial ENSG00000065911 'MTHFD2 upstream_gene_variant ENSG00000065911 ENSG00000065911 'MTHFD2 3 novel unspecific_effect MTHFD2 chr2 74186172 74217565 1 10797 protein_coding 2:74189113 2941 55_1_3 SeqId_13130_150 'HXK2 chr2:75040097_C_G$SeqId_13130_150 1 chr2:75040097_C_G rs687506 cis 2 75040097 C G 0.7264 -0.1088 0.0149 3.05e-13 'Hexokinase-2 ENSG00000159399 'HK2 intergenic_variant ENSG00000159399 ENSG00000159399 'HK2 3 novel specific_protein HK2 chr2 74834127 74893359 1 3099 protein_coding 2:74812970 21157 551_1_1 SeqId_5688_65 'CBLN4 chr20:54371100_C_T$SeqId_5688_65 1 chr20:54371100_C_T rs6024420 cis 20 54371100 T C 0.3087 -0.193 0.0144 8.85e-41 'Cerebellin-4 ENSG00000054803 'CBLN4 intergenic_variant ENSG00000054803 ENSG00000054803 'CBLN4 3 known specific_protein CBLN4 chr20 55997357 56005519 -1 140689 protein_coding 20:55796044 209475 551_1_2 SeqId_12855_16 'CT032 chr20:54988172_G_T$SeqId_12855_16 1 chr20:54988172_G_T rs67041321 cis 20 54988172 T G 0.8958 0.2101 0.0213 7.39e-23 'Cas scaffolding protein family member 4 ENSG00000087589 'CASS4 intron_variant 0.115808 rs35360819 ENSG00000087589 'CASS4 missense_variant ENSG00000087589 ENSG00000087589 'CASS4 3 novel specific_protein CASS4 chr20 56412112 56460387 1 57091 protein_coding 20:56413116 1004 552_1_2 SeqId_12408_333 'RB22A chr20:56887156_C_T$SeqId_12408_333 1 chr20:56887156_C_T rs12480383 cis 20 56887156 T C 0.072 0.213 0.0244 2.34e-18 'Ras-related protein Rab-22A ENSG00000124209 'RAB22A intron_variant ENSG00000124209 ENSG00000124209 'RAB22A 3 novel specific_pathway RAB22A chr20 58309715 58367507 1 57403 protein_coding 20:58312100 2385 552_1_5 SeqId_4971_1 'CATZ chr20:57795153_A_G$SeqId_4971_1 1 chr20:57795153_A_G rs75940688 cis 20 57795153 A G 0.0124 -1.0913 0.0619 1.75e-69 'Cathepsin Z ENSG00000101160 'CTSZ intron_variant 0.340743 rs199825459 ENSG00000101160 'CTSZ missense_variant ENSG00000101160 ENSG00000101160 'CTSZ 3 known specific_protein -1.1356 0.25396 9.6917008394729e-06 yes CTSZ Olink CARDIOVASCULAR III(v.6112) CTSZ chr20 58985686 59008238 -1 1522 protein_coding 20:59220098 211860 553_1_1 SeqId_18231_147 'PRND chr20:60916153_A_G$SeqId_18231_147 1 chr20:60916153_A_G rs6089351 trans 20 60916153 A G 0.6887 0.1531 0.0141 1.25e-27 'Prion-like protein doppel ENSG00000171864 'PRND intron_variant 0.640598 rs2274934 ENSG00000130702 'LAMA5 missense_variant none none ' novel unspecific_effect PRND chr20 4721909 4728460 1 23627 protein_coding 20:62341097 57619188 553_1_4 SeqId_7105_7 'CABL2 chr20:60985627_C_T$SeqId_7105_7 1 chr20:60985627_C_T rs2236201 cis 20 60985627 T C 0.5351 -0.0914 0.0131 3.05e-12 'CDK5 and ABL1 enzyme substrate 2 ENSG00000149679 'CABLES2 3_prime_UTR_variant 0.280476 rs184691263 ENSG00000149679 'CABLES2 missense_variant ENSG00000149679 ENSG00000149679 'CABLES2 3 novel unspecific_effect CABLES2 chr20 62388634 62407285 -1 81928 protein_coding 20:62410571 3286 554_1_1 SeqId_5070_76 'DcR3 chr20:62337406_A_G$SeqId_5070_76 1 chr20:62337406_A_G rs6011040 cis 20 62337406 A G 0.3263 0.1101 0.0146 3.93e-14 'Tumor necrosis factor receptor superfamily member 6B ENSG00000243509 'TNFRSF6B intron_variant ENSG00000243509 ENSG00000243509 'TNFRSF6B 3 known specific_protein TNFRSF6B chr20 63696652 63698684 1 8771 protein_coding 20:63706054 9402 554_1_2 SeqId_13481_24 'TCEA2 chr20:62698188_A_G$SeqId_13481_24 1 chr20:62698188_A_G rs34848242 cis 20 62698188 A G 0.3346 -0.3288 0.0133 5.6e-134 'Transcription elongation factor A protein 2 ENSG00000171703 'TCEA2 intron_variant ENSG00000171703 ENSG00000171703 'TCEA2 3 novel specific_protein TCEA2 chr20 64049836 64072347 1 6919 protein_coding 20:64066835 16999 555_1_1 SeqId_6507_16 'NCAM2 chr21:22839703_D_I$SeqId_6507_16 1 chr21:22839703_D_I rs72110960 cis 21 22839703 D I 0.3544 0.3393 0.014 6.06e-129 'Neural cell adhesion molecule 2 ENSG00000154654 'NCAM2 intron_variant ENSG00000154654 ENSG00000154654 'NCAM2 3 known specific_protein NCAM2 chr21 20998409 21543329 1 4685 protein_coding 21:21467383 468974 556_1_1 SeqId_3171_57 'amyloid precursor protein chr21:27523988_C_G$SeqId_3171_57 1 chr21:27523988_C_G rs455047 cis 21 27523988 C G 0.444 0.1046 0.0125 5.42e-17 'Amyloid beta A4 protein ENSG00000142192 'APP intron_variant ENSG00000142192 ENSG00000142192 'APP 3 novel specific_protein APP chr21 25880550 26171128 -1 351 protein_coding 21:26151670 19458 556_1_2 SeqId_3168_8 'ADAMTS-5 chr21:28305477_G_T$SeqId_3168_8 1 chr21:28305477_G_T rs2830586 cis 21 28305477 T G 0.8409 0.7278 0.0157 3.97e-469 'A disintegrin and metalloproteinase with thrombospondin motifs 5 ENSG00000154736 'ADAMTS5 intron_variant 0.999175 rs2830585 ENSG00000154736 'ADAMTS5 missense_variant ENSG00000154736 ENSG00000154736 'ADAMTS5 3 known specific_protein ADAMTS5 chr21 26917922 26967088 -1 11096 protein_coding 21:26933158 33930 557_1_1 SeqId_8877_22 'F176C chr21:33885578_C_T$SeqId_8877_22 1 chr21:33885578_C_T rs34028712 cis 21 33885578 T C 0.584 -0.1655 0.0134 7.86e-35 'Protein eva-1 homolog C ENSG00000166979 'EVA1C intron_variant ENSG00000166979 ENSG00000166979 'EVA1C 3 known specific_protein EVA1C chr21 32412006 32515397 1 59271 protein_coding 21:32513268 101262 557_2_1 SeqId_2631_50 'IL-10 Rb chr21:34656086_D_I$SeqId_2631_50 1 chr21:34656086_D_I rs68187568 cis 21 34656086 D I 0.451 0.1339 0.0139 7.67e-22 'Interleukin-10 receptor subunit beta ENSG00000243646 'IL10RB intron_variant ENSG00000243646 ENSG00000243646 'IL10RB 3 novel specific_pathway 0.5111 0.061973 1.56314764264096e-15 yes IL-10RB Olink INFLAMMATION(v.3012) IL10RB chr21 33266367 33310187 1 3588 protein_coding 21:33283782 17415 557_2_2 SeqId_9183_7 'IFN-a/b R1 chr21:34715699_C_G$SeqId_9183_7 1 chr21:34715699_C_G rs2257167 cis 21 34715699 C G 0.1349 -0.6973 0.018 2.76e-328 'Interferon alpha/beta receptor 1 ENSG00000142166 'IFNAR1 missense_variant ENSG00000142166 ENSG00000142166 'IFNAR1 3 known specific_protein IFNAR1 chr21 33324429 33359864 1 3454 protein_coding 21:33343393 18964 557_2_3 SeqId_9180_6 'INGR2 chr21:34776695_A_G$SeqId_9180_6 1 chr21:34776695_A_G rs2284553 cis 21 34776695 A G 0.4027 -0.1224 0.0137 4.6e-19 'Interferon gamma receptor 2 ENSG00000159128 'IFNGR2 intron_variant 0.108035 rs9808753 ENSG00000159128 'IFNGR2 missense_variant ENSG00000159128 ENSG00000159128 'IFNGR2 3 novel specific_protein IFNGR2 chr21 33403413 33479348 1 3460 protein_coding 21:33404389 976 559_1_1 SeqId_12381_26 'CBR1 chr21:37446599_A_C$SeqId_12381_26 1 chr21:37446599_A_C rs16993864 cis 21 37446599 A C 0.0196 -1.1984 0.0484 3.22e-135 'Carbonyl reductase [NADPH] 1 ENSG00000159228 'CBR1 downstream_gene_variant ENSG00000159228 ENSG00000159228 'CBR1 3 known specific_protein CBR1 chr21 36069941 36073166 1 873 protein_coding 21:36074301 4360 559_1_2 SeqId_14091_42 'Carbonyl reductase 3 chr21:37505827_G_T$SeqId_14091_42 1 chr21:37505827_G_T rs60043102 cis 21 37505827 T G 0.6473 0.5345 0.0127 4.45e-387 'Carbonyl reductase [NADPH] 3 ENSG00000159231 'CBR3 upstream_gene_variant 0.996825 rs1056892 ENSG00000159231 'CBR3 missense_variant ENSG00000159231 ENSG00000159231 'CBR3 3 known specific_protein CBR3 chr21 36135079 36146562 1 874 protein_coding 21:36133529 1550 56_1_1 SeqId_6572_10 'LRRT4 chr2:77713023_D_I$SeqId_6572_10 1 chr2:77713023_D_I rs148362453 cis 2 77713023 D I 0.7081 0.11 0.0152 4.72e-13 'Leucine-rich repeat transmembrane neuronal protein 4 ENSG00000176204 'LRRTM4 intron_variant ENSG00000176204 ENSG00000176204 'LRRTM4 3 novel specific_protein LRRTM4 chr2 76747685 77593319 -1 80059 protein_coding 2:77485898 107421 560_1_1 SeqId_9175_48 'DSCAM chr21:42060498_C_T$SeqId_9175_48 1 chr21:42060498_C_T rs78111814 cis 21 42060498 T C 0.9556 -0.5241 0.0339 7.59e-54 'Down syndrome cell adhesion molecule ENSG00000171587 'DSCAM intron_variant ENSG00000171587 ENSG00000171587 'DSCAM 3 known specific_protein DSCAM chr21 40010999 40847158 -1 1826 protein_coding 21:40688572 158586 560_1_5 SeqId_5618_50 'FAM3B chr21:42718262_C_T$SeqId_5618_50 1 chr21:42718262_C_T rs57529409 cis 21 42718262 T C 0.0477 -0.545 0.0318 4.86e-66 'Protein FAM3B ENSG00000183844 'FAM3B intron_variant ENSG00000183844 ENSG00000183844 'FAM3B 3 known unspecific_effect -1.2781 0.12815 1.96788628970685e-21 yes FAM3B Olink IMMUNE RESPONSE(v.3202) FAM3B chr21 41304212 41357727 1 54097 protein_coding 21:41346335 42123 560_1_6 SeqId_9177_6 'FAM3B chr21:42721107_A_C$SeqId_9177_6 1 chr21:42721107_A_C rs17000823 cis 21 42721107 A C 0.9618 0.8493 0.034 2.58e-137 'Protein FAM3B ENSG00000183844 'FAM3B intron_variant ENSG00000183844 ENSG00000183844 'FAM3B 3 known unspecific_effect 1.2544 0.1486 3.66437574647833e-16 yes FAM3B Olink IMMUNE RESPONSE(v.3202) FAM3B chr21 41304212 41357727 1 54097 protein_coding 21:41349180 44968 560_1_7 SeqId_17460_51 'Mx1 chr21:42798173_A_C$SeqId_17460_51 1 chr21:42798173_A_C rs464138 cis 21 42798173 A C 0.5868 0.4531 0.013 1.89e-267 'Interferon-induced GTP-binding protein Mx1 ENSG00000157601 'MX1 intron_variant 0.332269 rs469390 ENSG00000157601 'MX1 missense_variant ENSG00000157601 ENSG00000157601 'MX1 3 novel specific_protein MX1 chr21 41420020 41470071 1 4599 protein_coding 21:41426246 6226 560_2_1 SeqId_8323_163 'TFF3 chr21:43741067_C_T$SeqId_8323_163 1 chr21:43741067_C_T rs75307655 cis 21 43741067 T C 0.99 0.8266 0.0663 1.02e-35 'Trefoil factor 3 ENSG00000160180 'TFF3 intergenic_variant 0.598173 rs118095917 ENSG00000160180 'TFF3 missense_variant ENSG00000160180 ENSG00000160180 'TFF3 3 novel unspecific_effect 1.289 0.26273 1.2726236800229e-06 yes TFF3 Olink CARDIOVASCULAR III(v.6112) TFF3 chr21 42311667 42315409 -1 7033 protein_coding 21:42320957 5548 560_2_1 SeqId_4721_54 'TFF3 chr21:43741067_C_T$SeqId_4721_54 1 chr21:43741067_C_T rs75307655 cis 21 43741067 T C 0.99 0.5146 0.0655 4.06e-15 'Trefoil factor 3 ENSG00000160180 'TFF3 intergenic_variant 0.598173 rs118095917 ENSG00000160180 'TFF3 missense_variant ENSG00000160180 ENSG00000160180 'TFF3 3 novel unspecific_effect 1.289 0.26273 1.2726236800229e-06 yes TFF3 Olink CARDIOVASCULAR III(v.6112) TFF3 chr21 42311667 42315409 -1 7033 protein_coding 21:42320957 5548 560_2_2 SeqId_9191_8 'Trefoil factor 2 chr21:43768324_C_T$SeqId_9191_8 1 chr21:43768324_C_T rs13047301 cis 21 43768324 T C 0.3204 0.12 0.0136 1.3e-18 'Trefoil factor 2 ENSG00000160181 'TFF2 intron_variant ENSG00000160181 ENSG00000160181 'TFF2 3 known specific_pathway TFF2 chr21 42346357 42350997 -1 7032 protein_coding 21:42348215 2782 560_2_3 SeqId_9185_15 'TFF1 chr21:43787038_A_G$SeqId_9185_15 1 chr21:43787038_A_G rs3761376 cis 21 43787038 A G 0.233 -0.3453 0.0154 5.47e-111 'Trefoil factor 1 ENSG00000160182 'TFF1 upstream_gene_variant ENSG00000160182 ENSG00000160182 'TFF1 3 known specific_pathway TFF1 chr21 42362282 42366535 -1 7031 protein_coding 21:42366929 394 561_1_1 SeqId_11098_1 'PDXK chr21:45077398_C_G$SeqId_11098_1 1 chr21:45077398_C_G rs7279968 cis 21 45077398 C G 0.4411 0.2628 0.0134 1.62e-85 'Pyridoxal kinase ENSG00000160209 'PDXK intron_variant ENSG00000160209 ENSG00000160209 'PDXK 3 novel suggestive_specific_pathway PDXK chr21 43719094 43762307 1 8566 protein_coding 21:43657517 61577 561_1_3 SeqId_5061_27 'B7-H2 chr21:45653764_C_G$SeqId_5061_27 1 chr21:45653764_C_G rs7278257 cis 21 45653764 C G 0.269 -0.1066 0.0153 3.01e-12 'ICOS ligand ENSG00000160223 'ICOSLG intron_variant 0.943403 rs11558819 ENSG00000160223 'ICOSLG missense_variant ENSG00000160223 ENSG00000160223 'ICOSLG 3 known specific_protein ICOSLG chr21 44217014 44240966 -1 23308 protein_coding 21:44233881 7085 561_2_2 SeqId_2201_17 'Endostatin chr21:46930092_A_G$SeqId_2201_17 1 chr21:46930092_A_G rs144147445 cis 21 46930092 A G 0.0184 -1.4332 0.0491 2.18e-187 'Endostatin ENSG00000182871 'COL18A1 missense_variant ENSG00000182871 ENSG00000182871 'COL18A1 3 known suggestive_specific_pathway -0.21935 0.20922 0.294971461497835 no COL18A1 Olink CARDIOMETABOLIC(v.3602) COL18A1 chr21 45405165 45513720 1 80781 protein_coding 21:45510178 105013 561_2_5 SeqId_16828_8 'Collagen a1(VI) chr21:47420723_C_G$SeqId_16828_8 1 chr21:47420723_C_G rs13053065 cis 21 47420723 C G 0.3106 -1.2752 0.0081 5.49e-5385 'Collagen alpha-1(VI) chain ENSG00000142156 'COL6A1 intron_variant 0.995323 rs1053312 ENSG00000142156 'COL6A1 missense_variant ENSG00000142156 ENSG00000142156 'COL6A1 3 novel specific_protein COL6A1 chr21 45981770 46005050 1 1291 protein_coding 21:46000809 19039 561_3_2 SeqId_16753_46 'CO6A2 chr21:47552209_A_G$SeqId_16753_46 1 chr21:47552209_A_G rs35548026 cis 21 47552209 A G 0.0888 -0.4933 0.023 2.82e-102 'Collagen alpha-2(VI) chain ENSG00000142173 'COL6A2 missense_variant ENSG00000142173 ENSG00000142173 'COL6A2 3 novel suggestive_specific_pathway COL6A2 chr21 46098112 46132848 1 1292 protein_coding 21:46132295 34183 561_3_3 SeqId_9213_24 'FTCD chr21:47572887_C_T$SeqId_9213_24 1 chr21:47572887_C_T rs61735836 cis 21 47572887 T C 0.0404 0.671 0.0425 2.94e-56 'Formimidoyltransferase-cyclodeaminase ENSG00000160282 'FTCD missense_variant ENSG00000160282 ENSG00000160282 'FTCD 3 novel specific_protein FTCD chr21 46136160 46155579 -1 10841 protein_coding 21:46152973 2606 562_1_1 SeqId_6077_63 'CECR1 chr22:17669306_C_T$SeqId_6077_63 1 chr22:17669306_C_T rs2231495 cis 22 17669306 T C 0.6734 0.8072 0.012 3.35e-985 'Adenosine deaminase CECR1 ENSG00000093072 'CECR1 missense_variant ENSG00000093072 ENSG00000093072 'ADA2 8 known specific_pathway ADA2 chr22 17178790 17258235 -1 51816 protein_coding 22:17188416 69819 562_1_2 SeqId_2992_59 'IL-17 sR chr22:17586631_A_G$SeqId_2992_59 1 chr22:17586631_A_G rs4819959 cis 22 17586631 A G 0.5007 0.8061 0.011 8.08e-1169 'Interleukin-17 receptor A ENSG00000177663 'IL17RA intron_variant 0.293828 rs879577 ENSG00000177663 'IL17RA missense_variant ENSG00000177663 ENSG00000177663 'IL17RA 3 known suggestive_specific_pathway 0.67793 0.055126 1.9815270258051e-30 yes IL-17RA Olink CARDIOVASCULAR III(v.6112) IL17RA chr22 17084954 17115694 1 23765 protein_coding 22:17105741 20787 562_2_1 SeqId_5798_3 'BID chr22:18217384_A_C$SeqId_5798_3 1 chr22:18217384_A_C rs151268390 cis 22 18217384 A C 0.9857 0.4196 0.0596 1.98e-12 'BH3-interacting domain death agonist ENSG00000015475 'BID 3_prime_UTR_variant ENSG00000015475 ENSG00000015475 'BID 3 novel specific_protein 0.51286 0.27097 0.0590065196995666 no BID Olink ORGAN DAMAGE(v.3301) BID chr22 17734138 17774770 -1 637 protein_coding 22:17734618 40152 562_3_1 SeqId_11356_19 'DGC14 chr22:19133605_A_G$SeqId_11356_19 1 chr22:19133605_A_G rs715544 cis 22 19133605 A G 0.0917 -0.4069 0.023 6.93e-70 'Protein DGCR14 ENSG00000100056 'DGCR14 upstream_gene_variant 0.117656 rs113904207 ENSG00000100056 'DGCR14 missense_variant ENSG00000100056 ENSG00000100056 'ESS2 3 novel specific_protein ESS2 chr22 19130279 19144684 -1 8220 protein_coding 22:19146092 1408 562_4_1 SeqId_18382_109 'Catechol O-methyltransferase chr22:19948863_C_G$SeqId_18382_109 1 chr22:19948863_C_G rs165656 cis 22 19948863 C G 0.5173 -0.1217 0.0136 4.69e-19 'Catechol O-methyltransferase ENSG00000093010 'COMT intron_variant 0.983002 rs4680 ENSG00000093010 'COMT missense_variant ENSG00000093010 ENSG00000093010 'COMT 3 known specific_protein COMT chr22 19941371 19969975 1 1312 protein_coding 22:19961340 19969 562_4_2 SeqId_5105_2 'Nogo Receptor chr22:20173526_C_G$SeqId_5105_2 1 chr22:20173526_C_G rs175206 cis 22 20173526 C G 0.7467 -0.3413 0.0152 3.44e-111 'Reticulon-4 receptor ENSG00000040608 'RTN4R intergenic_variant ENSG00000040608 ENSG00000040608 'RTN4R 3 known specific_protein -0.26876 0.068022 8.94128627502953e-05 yes RTN4R Olink METABOLISM(v.3402) RTN4R chr22 20241415 20283246 -1 65078 protein_coding 22:20186003 97243 562_4_3 SeqId_8956_96 'SREC-II chr22:20778066_A_G$SeqId_8956_96 1 chr22:20778066_A_G rs738084 cis 22 20778066 A G 0.193 -0.255 0.0159 3.88e-58 'Scavenger receptor class F member 2 ENSG00000244486 'SCARF2 downstream_gene_variant 0.998148 rs361566 ENSG00000244486 'SCARF2 missense_variant ENSG00000244486 ENSG00000244486 'SCARF2 3 known specific_protein -0.49779 0.072245 1.75792361395869e-11 yes SCARF2 Olink NEUROLOGY(v.8011) SCARF2 chr22 20424584 20437826 -1 91179 protein_coding 22:20423776 14050 562_4_4 SeqId_12357_41 'SNP29 chr22:21040925_A_G$SeqId_12357_41 1 chr22:21040925_A_G rs73159197 cis 22 21040925 A G 0.9176 0.2949 0.0234 1.57e-36 'Synaptosomal-associated protein 29 ENSG00000099940 'SNAP29 upstream_gene_variant ENSG00000099940 ENSG00000099940 'SNAP29 3 novel specific_protein -0.071234 0.12274 0.561953007700132 no SNAP29 Olink DEVELOPMENT(v.3511) SNAP29 chr22 20859007 20891214 1 9342 protein_coding 22:20686637 172370 562_4_5 SeqId_6990_44 'SDF2L chr22:21998280_A_G$SeqId_6990_44 1 chr22:21998280_A_G rs73166641 cis 22 21998280 A G 0.0146 1.0037 0.0555 4.23e-73 'Stromal cell-derived factor 2-like protein 1 ENSG00000128228 'SDF2L1 missense_variant ENSG00000128228 ENSG00000128228 'SDF2L1 3 novel specific_protein SDF2L1 chr22 21642302 21644299 1 23753 protein_coding 22:21643991 1689 562_5_8 SeqId_6485_59 'IGLL1 chr22:22606039_C_T$SeqId_6485_59 1 chr22:22606039_C_T rs76043508 trans 22 22606039 T C 0.9425 0.2084 0.0288 4.31e-13 'Immunoglobulin lambda-like polypeptide 1 ENSG00000128322 'IGLL1 intergenic_variant 0.971011 rs1320 ENSG00000169575 'VPREB1 missense_variant ENSG00000169575 ENSG00000169575 'VPREB1 4 novel unspecific_effect IGLL1 chr22 23573125 23580302 -1 3543 protein_coding 22:22251649 1328653 562_6_1 SeqId_6485_59 'IGLL1 chr22:23922552_A_G$SeqId_6485_59 1 chr22:23922552_A_G rs9624216 cis 22 23922552 A G 0.0922 -0.5362 0.0254 1.36e-98 'Immunoglobulin lambda-like polypeptide 1 ENSG00000128322 'IGLL1 upstream_gene_variant 0.119682 rs116041505 ENSG00000128322 'IGLL1 missense_variant ENSG00000128322 ENSG00000128322 'IGLL1 3 known specific_protein IGLL1 chr22 23573125 23580302 -1 3543 protein_coding 22:23580365 63 562_6_2 SeqId_11270_17 'CHC10 chr22:24018473_D_I$SeqId_11270_17 1 chr22:24018473_D_I rs144959026 cis 22 24018473 D I 0.5143 0.1247 0.0135 2.41e-20 'Coiled-coil-helix-coiled-coil-helix domain-containing protein 10, mitochondrial ENSG00000250479 'CHCHD10 intron_variant,non_coding_transcript_variant ENSG00000250479 ENSG00000250479 'CHCHD10 3 novel specific_protein CHCHD10 chr22 23765834 23767972 -1 400916 protein_coding 22:23676287 91685 562_6_3 SeqId_11273_176 'GSTT2 chr22:24267047_C_T$SeqId_11273_176 1 chr22:24267047_C_T rs5751777 cis 22 24267047 T C 0.5911 -0.5794 0.0128 2.07e-447 'Glutathione S-transferase theta-2B ENSG00000133433 'GSTT2B upstream_gene_variant ENSG00000133433 ENSG00000133433 'GSTT2B 3 known unspecific_effect GSTT2B chr22 23957414 23961195 -1 653689 protein_coding 22:23924860 36335 562_6_4 SeqId_19237_17 'D-dopachrome decarboxylase chr22:24298603_C_T$SeqId_19237_17 1 chr22:24298603_C_T rs140117085 cis 22 24298603 T C 0.0355 0.558 0.0386 2.7e-47 'D-dopachrome decarboxylase ENSG00000099977 'DDT downstream_gene_variant ENSG00000099977 ENSG00000099977 'DDT 3 novel suggestive_specific_pathway DDT chr22 23971365 23979828 -1 1652 protein_coding 22:23956416 23412 563_1_1 SeqId_19563_3 'SEZ6L chr22:26766663_D_I$SeqId_19563_3 1 chr22:26766663_D_I rs111967410 cis 22 26766663 D I 0.1791 -0.142 0.0168 2.85e-17 'Seizure 6-like protein ENSG00000100095 'SEZ6L intron_variant 0.116738 rs663048 ENSG00000100095 'SEZ6L missense_variant ENSG00000100095 ENSG00000100095 'SEZ6L 3 novel specific_protein SEZ6L chr22 26169462 26383597 1 23544 protein_coding 22:26370698 201236 563_2_1 SeqId_8024_64 'TPST2 chr22:26923325_A_G$SeqId_8024_64 1 chr22:26923325_A_G rs6005067 cis 22 26923325 A G 0.425 0.245 0.0129 4.25e-80 'Protein-tyrosine sulfotransferase 2 ENSG00000128294 'TPST2 intron_variant ENSG00000128294 ENSG00000128294 'TPST2 3 known specific_protein TPST2 chr22 26521996 26596717 -1 8459 protein_coding 22:26527359 69358 563_2_2 SeqId_17751_68 'CRBB1 chr22:27012894_A_G$SeqId_17751_68 1 chr22:27012894_A_G rs4822754 cis 22 27012894 A G 0.4657 0.256 0.013 2.57e-86 'Beta-crystallin B1 ENSG00000100122 'CRYBB1 intron_variant ENSG00000100122 ENSG00000100122 'CRYBB1 3 novel specific_protein CRYBB1 chr22 26599278 26618027 -1 1414 protein_coding 22:26616930 1097 564_1_1 SeqId_17331_138 'KREM1 chr22:29543415_A_G$SeqId_17331_138 1 chr22:29543415_A_G rs713526 cis 22 29543415 A G 0.0103 -1.3532 0.0664 2.9e-92 'Kremen protein 1 ENSG00000183762 'KREMEN1 intron_variant 0.650711 rs61751700 ENSG00000183762 'KREMEN1 missense_variant ENSG00000183762 ENSG00000183762 'KREMEN1 3 known specific_protein KREMEN1 chr22 29073035 29168333 1 83999 protein_coding 22:29147427 74392 564_2_1 SeqId_15560_52 'Apo-TC II chr22:31009820_C_G$SeqId_15560_52 1 chr22:31009820_C_G rs5753236 cis 22 31009820 C G 0.5542 -1.1368 0.0078 1.87e-4615 'Transcobalamin-2 ENSG00000185339 'TCN2 intron_variant 0.999322 rs1801198 ENSG00000185339 'TCN2 missense_variant ENSG00000185339 ENSG00000185339 'TCN2 3 known unspecific_effect 0.54248 0.059514 2.0941124558509e-18 no TCN2 Olink CARDIOMETABOLIC(v.3602) TCN2 chr22 30607003 30627271 1 6948 protein_coding 22:30613833 6830 564_2_1 SeqId_5584_21 'Holo-TC II chr22:31011610_C_G$SeqId_5584_21 1 chr22:31011610_C_G rs1801198 cis 22 31011610 C G 0.5539 -0.5909 0.0118 4.75e-547 'Holo-Transcobalamin-2 ENSG00000185339 'TCN2 missense_variant ENSG00000185339 ENSG00000185339 'TCN2 3 known unspecific_effect 0.53626 0.059715 6.01173737483278e-18 no TCN2 Olink CARDIOMETABOLIC(v.3602) TCN2 chr22 30607003 30627271 1 6948 protein_coding 22:30615623 8620 564_4_1 SeqId_2480_58 'TIMP-3 chr22:33159962_C_T$SeqId_2480_58 1 chr22:33159962_C_T rs5754256 cis 22 33159962 T C 0.7237 -0.9666 0.0114 7.03e-1564 'Metalloproteinase inhibitor 3 ENSG00000100234 'TIMP3 intron_variant ENSG00000100234 ENSG00000100234 'TIMP3 4 known unspecific_effect TIMP3 chr22 32801705 32863041 1 7078 protein_coding 22:32763976 37729 564_4_5 SeqId_7935_26 'LARGE chr22:34316077_A_G$SeqId_7935_26 1 chr22:34316077_A_G rs3210587 cis 22 34316077 A G 0.3673 0.1095 0.013 3.44e-17 'Glycosyltransferase-like protein LARGE1 ENSG00000133424 'LARGE 5_prime_UTR_variant ENSG00000133424 ENSG00000133424 'LARGE1 3 novel specific_protein LARGE1 chr22 33162226 33922841 -1 9215 protein_coding 22:33920089 2752 565_1_2 SeqId_17398_55 'HO-1 chr22:35778262_C_T$SeqId_17398_55 1 chr22:35778262_C_T rs73172715 cis 22 35778262 T C 0.9465 0.2092 0.0292 7.54e-13 'Heme oxygenase 1 ENSG00000100292 'HMOX1 intron_variant ENSG00000100292 ENSG00000100292 'HMOX1 3 novel specific_protein HMOX1 chr22 35380361 35394214 1 3162 protein_coding 22:35382269 1908 565_1_3 SeqId_16823_75 'APOL3 chr22:36545137_A_T$SeqId_16823_75 1 chr22:36545137_A_T rs132642 cis 22 36545137 A T 0.1657 -1.0239 0.0152 5.52e-988 'Apolipoprotein L3 ENSG00000128284 'APOL3 intron_variant 0.897925 rs132653 ENSG00000128284 'APOL3 missense_variant ENSG00000128284 ENSG00000128284 'APOL3 3 novel specific_protein APOL3 chr22 36140330 36166177 -1 80833 protein_coding 22:36149089 17088 565_1_4 SeqId_11510_31 'Apo L1 chr22:36653752_C_G$SeqId_11510_31 1 chr22:36653752_C_G rs9610469 cis 22 36653752 C G 0.6912 0.4738 0.0142 1.13e-243 'Apolipoprotein L1 ENSG00000100342 'APOL1 intron_variant 0.524521 rs136175 ENSG00000100342 'APOL1 missense_variant ENSG00000100342 ENSG00000100342 'APOL1 3 known specific_protein APOL1 chr22 36253071 36267530 1 8542 protein_coding 22:36257706 4635 565_1_5 SeqId_10512_13 'IL3RB chr22:37330811_C_G$SeqId_10512_13 1 chr22:37330811_C_G rs5756415 cis 22 37330811 C G 0.5403 0.7246 0.0116 6.46e-850 'Cytokine receptor common subunit beta ENSG00000100368 'CSF2RB intron_variant ENSG00000100368 ENSG00000100368 'CSF2RB 3 known specific_protein CSF2RB chr22 36913628 36940439 1 1439 protein_coding 22:36934769 21141 565_1_6 SeqId_9343_16 'IL-2 sRb chr22:37533795_C_G$SeqId_9343_16 1 chr22:37533795_C_G rs228958 cis 22 37533795 C G 0.4387 0.0971 0.0131 1.04e-13 'Interleukin-2 receptor subunit beta ENSG00000100385 'IL2RB intron_variant 0.20791 rs228942 ENSG00000100385 'IL2RB missense_variant ENSG00000100385 ENSG00000100385 'IL2RB 3 novel specific_protein IL2RB chr22 37125843 37175054 -1 3560 protein_coding 22:37137755 37299 565_2_1 SeqId_5605_77 'MFNG chr22:37866063_A_G$SeqId_5605_77 1 chr22:37866063_A_G rs8192548 cis 22 37866063 A G 0.0188 -0.5973 0.0496 1.86e-33 'Beta-1,3-N-acetylglucosaminyltransferase manic fringe ENSG00000100060 'MFNG missense_variant ENSG00000100060 ENSG00000100060 'MFNG 3 novel specific_protein MFNG chr22 37469063 37486393 -1 4242 protein_coding 22:37470025 16368 565_2_2 SeqId_3033_57 'Galectin-2 chr22:37965438_A_C$SeqId_3033_57 1 chr22:37965438_A_C rs12484334 cis 22 37965438 A C 0.6098 -0.2826 0.0136 2.68e-95 'Galectin-2 ENSG00000100079 'LGALS2 downstream_gene_variant ENSG00000100079 ENSG00000100079 'LGALS2 3 known specific_protein LGALS2 chr22 37570248 37582616 -1 3957 protein_coding 22:37569431 13185 565_2_4 SeqId_15511_37 'NPTXR chr22:39245556_A_G$SeqId_15511_37 1 chr22:39245556_A_G rs74703065 cis 22 39245556 A G 0.0196 1.3143 0.0459 5.07e-180 'Neuronal pentraxin receptor ENSG00000221890 'NPTXR intergenic_variant ENSG00000221890 ENSG00000221890 'NPTXR 3 known specific_protein 2.0376 0.22703 6.29506182857197e-18 yes NPTXR Olink METABOLISM(v.3402) NPTXR chr22 38818452 38844028 -1 23467 protein_coding 22:38849551 5523 565_3_2 SeqId_13930_3 'ABC3G chr22:39472177_A_C$SeqId_13930_3 1 chr22:39472177_A_C rs6519166 cis 22 39472177 A C 0.674 -0.1833 0.0133 4.86e-43 'DNA dC->dU-editing enzyme APOBEC-3G ENSG00000239713 'APOBEC3G upstream_gene_variant ENSG00000239713 ENSG00000239713 'APOBEC3G 3 novel specific_protein APOBEC3G chr22 39077067 39087743 1 60489 protein_coding 22:39076172 895 566_1_1 SeqId_17408_2 'PMM1 chr22:42091027_D_I$SeqId_17408_2 1 chr22:42091027_D_I rs35117663 cis 22 42091027 D I 0.1924 -0.1219 0.0173 1.6e-12 'Phosphomannomutase 1 ENSG00000100417 'PMM1 3_prime_UTR_variant 0.120252 rs143715682 ENSG00000100417 'PMM1 missense_variant ENSG00000100417 ENSG00000100417 'PMM1 3 known specific_protein PMM1 chr22 41576900 41589871 -1 5372 protein_coding 22:41695024 105153 566_1_2 SeqId_15300_66 'CC134 chr22:42230349_D_I$SeqId_15300_66 1 chr22:42230349_D_I rs10608168 cis 22 42230349 D I 0.5637 0.1537 0.0128 2.6e-33 'Coiled-coil domain-containing protein 134 ENSG00000100147 'CCDC134 intron_variant ENSG00000100147 ENSG00000100147 'CCDC134 3 known specific_protein CCDC134 chr22 41800679 41832164 1 79879 protein_coding 22:41834346 33667 566_2_1 SeqId_8759_29 'a1,4-Galactosyltransferase chr22:43115519_D_I$SeqId_8759_29 1 chr22:43115519_D_I rs66781836 cis 22 43115519 D I 0.4741 -0.2709 0.0132 2.19e-93 'Lactosylceramide 4-alpha-galactosyltransferase ENSG00000128274 'A4GALT intron_variant ENSG00000128274 ENSG00000128274 'A4GALT 3 known specific_protein A4GALT chr22 42692121 42721298 -1 53947 protein_coding 22:42719514 1784 566_3_2 SeqId_8989_40 'SCUB1 chr22:43715862_C_T$SeqId_8989_40 1 chr22:43715862_C_T rs2744874 cis 22 43715862 T C 0.8643 -0.2082 0.0173 3.28e-33 'Signal peptide, CUB and EGF-like domain-containing protein 1 ENSG00000159307 'SCUBE1 intron_variant ENSG00000159307 ENSG00000159307 'SCUBE1 3 known specific_protein SCUBE1 chr22 43197280 43343372 -1 80274 protein_coding 22:43319856 23516 567_1_1 SeqId_6470_19 'fibulin 1 chr22:45846371_C_T$SeqId_6470_19 1 chr22:45846371_C_T rs11090631 cis 22 45846371 T C 0.1912 -0.2105 0.0166 5.19e-37 'Fibulin-1 ENSG00000077942 'FBLN1 upstream_gene_variant ENSG00000077942 ENSG00000077942 'FBLN1 3 known specific_protein FBLN1 chr22 45502238 45601135 1 2192 protein_coding 22:45450490 51748 568_1_1 SeqId_13242_134 'SHAN3 chr22:51106979_C_G$SeqId_13242_134 1 chr22:51106979_C_G rs9616907 none 22 51106979 C G 0.442 -0.5143 0.012 2.54e-401 'SH3 and multiple ankyrin repeat domains protein 3 upstream_gene_variant 0.742788 rs9616915 ENSG00000251322 'SHANK3 missense_variant ENSG00000212569 ENSG00000100312|ENSG00000212569|ENSG00000251322 'ACR|SHANK3 1 known suggestive_specific_pathway SHANK3 chr22 50674415 50733298 1 85358 protein_coding 22:50668551 5864 568_1_3 SeqId_5005_4 'MK12 chr22:50704267_C_T$SeqId_5005_4 1 chr22:50704267_C_T rs9617128 cis 22 50704267 T C 0.7608 -0.4298 0.0145 2.53e-192 'Mitogen-activated protein kinase 12 ENSG00000188130 'MAPK12 intron_variant ENSG00000188130 ENSG00000188130 'MAPK12 3 novel unspecific_effect MAPK12 chr22 50245450 50261716 -1 6300 protein_coding 22:50265838 4122 568_1_4 SeqId_9216_100 'PLXB2 chr22:50727921_C_T$SeqId_9216_100 1 chr22:50727921_C_T rs28578714 cis 22 50727921 T C 0.6074 -0.5949 0.0124 2.62e-502 'Plexin-B2 ENSG00000196576 'PLXNB2 intron_variant 0.995809 rs28379706 ENSG00000196576 'PLXNB2 missense_variant ENSG00000196576 ENSG00000196576 'PLXNB2 3 known suggestive_specific_pathway 0.04449 0.065476 0.497152926224281 no PLXNB2 Olink CARDIOMETABOLIC(v.3602) PLXNB2 chr22 50274979 50307646 -1 23654 protein_coding 22:50289492 18154 568_1_5 SeqId_8100_15 'ADM2 chr22:50921148_D_I$SeqId_8100_15 1 chr22:50921148_D_I rs72438078 cis 22 50921148 D I 0.105 0.1804 0.0224 7.19e-16 'ADM2 ENSG00000128165 'ADM2 inframe_insertion ENSG00000128165 ENSG00000128165 'ADM2 3 known unspecific_effect ADM2 chr22 50481543 50486440 1 79924 protein_coding 22:50482720 1177 568_1_6 SeqId_16851_50 'SCO2 chr22:50963905_C_T$SeqId_16851_50 1 chr22:50963905_C_T rs74479613 cis 22 50963905 T C 0.0901 -0.3674 0.0216 1.18e-64 'Protein SCO2 homolog, mitochondrial ENSG00000130489 'SCO2 intron_variant 0.149292 rs140523 ENSG00000130489 'SCO2 missense_variant ENSG00000130489 ENSG00000130489 ' 3 novel suggestive_specific_pathway SCO2 chr22 50523568 50526461 -1 9997 protein_coding 22:50525476 985 568_1_7 SeqId_7761_125 'CHKB chr22:51024542_C_T$SeqId_7761_125 1 chr22:51024542_C_T rs5770924 cis 22 51024542 T C 0.0504 -0.2357 0.0296 1.85e-15 'Choline/ethanolamine kinase ENSG00000100288 'CHKB upstream_gene_variant ENSG00000100288 ENSG00000100288 'CHKB 3 novel unspecific_effect CHKB chr22 50578959 50601455 -1 1120 protein_coding 22:50586113 15342 568_1_8 SeqId_3583_54 'Arylsulfatase A chr22:51064915_A_G$SeqId_3583_54 1 chr22:51064915_A_G rs6151419 cis 22 51064915 A G 0.1607 -0.3625 0.0182 1.68e-88 'Arylsulfatase A ENSG00000100299 'ARSA intron_variant 0.654103 rs2071421 ENSG00000100299 'ARSA missense_variant ENSG00000100299 ENSG00000100299 'ARSA 3 novel specific_protein -0.17787 0.087922 0.0436214401908049 yes ARSA Olink DEVELOPMENT(v.3511) ARSA chr22 50622754 50628173 -1 410 protein_coding 22:50626487 1686 569_1_1 SeqId_10438_19 'CSF2R chr23:1423039_C_T$SeqId_10438_19 1 chr23:1423039_C_T rs78468042 cis 23 1423039 T C 0.5993 -1.0471 0.0111 3.82e-1935 'Granulocyte-macrophage colony-stimulating factor receptor subunit alpha ENSG00000198223 'CSF2RA intron_variant ENSG00000198223 ENSG00000198223 'CSF2RA 3 novel specific_protein CSF2RA chrX 1268800 1310381 1 1438 protein_coding X:1304146 35346 569_1_2 SeqId_13744_37 'IL-3 Ra chr23:1464184_G_T$SeqId_13744_37 1 chr23:1464184_G_T rs17884006 cis 23 1464184 T G 0.5601 0.1393 0.0144 4.6e-22 'Interleukin-3 receptor subunit alpha ENSG00000185291 'IL3RA intron_variant ENSG00000185291 ENSG00000185291 'IL3RA 3 novel specific_protein IL3RA chrX 1336616 1382689 1 3563 protein_coding X:1345291 8675 569_1_3 SeqId_10089_7 'ASML chr23:1537881_C_T$SeqId_10089_7 1 chr23:1537881_C_T rs4503285 cis 23 1537881 T C 0.2515 0.4015 0.0161 1.42e-136 'N-acetylserotonin O-methyltransferase-like protein ENSG00000169093 'ASMTL missense_variant ENSG00000169093 ENSG00000169093 'ASMTL 3 novel specific_protein ASMTL chrX 1403139 1453762 -1 8623 protein_coding X:1418988 34774 57_1_1 SeqId_16770_3 'REG1B chr2:79323888_A_G$SeqId_16770_3 1 chr2:79323888_A_G rs11126696 cis 2 79323888 A G 0.3826 -0.269 0.0137 2.3e-86 'Lithostathine-1-beta ENSG00000172023 'REG1B intergenic_variant ENSG00000172023 ENSG00000172023 'REG1B 3 known specific_pathway REG1B chr2 79085023 79088019 -1 5968 protein_coding 2:79096762 8743 57_1_2 SeqId_13095_51 'PSP chr2:79330169_G_T$SeqId_13095_51 1 chr2:79330169_G_T rs76841471 cis 2 79330169 T G 0.922 -0.5166 0.0255 2.13e-91 'Lithostathine-1-alpha ENSG00000115386 'REG1A intergenic_variant ENSG00000115386 ENSG00000115386 'REG1A 3 known suggestive_specific_pathway -0.50632 0.11461 1.23196962456923e-05 yes REG1A Olink CARDIOMETABOLIC(v.3602) REG1A chr2 79120362 79123409 1 5967 protein_coding 2:79103043 17319 57_1_3 SeqId_15476_6 'REG3G chr2:79307817_A_G$SeqId_15476_6 1 chr2:79307817_A_G rs2861742 cis 2 79307817 A G 0.2571 0.4818 0.0142 1.36e-251 'Regenerating islet-derived protein 3-gamma ENSG00000143954 'REG3G downstream_gene_variant ENSG00000143954 ENSG00000143954 'REG3G 3 known specific_pathway REG3G chr2 79025686 79028505 1 130120 protein_coding 2:79080691 55005 57_1_4 SeqId_15304_1 'PAP1 chr2:79397366_A_G$SeqId_15304_1 1 chr2:79397366_A_G rs4459759 cis 2 79397366 A G 0.0546 0.4466 0.029 2.1e-53 'Regenerating islet-derived protein 3-alpha ENSG00000172016 'REG3A intron_variant,non_coding_transcript_variant ENSG00000172016 ENSG00000172016 'REG3A 3 known specific_protein 0.32246 0.12375 0.00945148392440729 yes REG3A Olink CARDIOMETABOLIC(v.3602) REG3A chr2 79157003 79159753 -1 5068 protein_coding 2:79170240 10487 570_1_2 SeqId_8044_90 'XG chr23:2700157_A_G$SeqId_8044_90 1 chr23:2700157_A_G rs5939319 cis 23 2700157 A G 0.1424 0.2167 0.0169 1.3e-37 'Glycoprotein Xg ENSG00000124343 'XG missense_variant ENSG00000124343 ENSG00000124343 'XG 3 novel specific_protein XG chrX 2752040 2816500 1 7499 protein_coding X:2782116 30076 571_1_1 SeqId_5357_60 'NLGNX chr23:5939658_D_I$SeqId_5357_60 1 chr23:5939658_D_I rs58025219 cis 23 5939658 D I 0.8159 -0.1038 0.0143 4.62e-13 'Neuroligin-4, X-linked ENSG00000146938 'NLGN4X intron_variant ENSG00000146938 ENSG00000146938 'NLGN4X 3 novel specific_protein NLGN4X chrX 5840637 6228867 -1 57502 protein_coding X:6021618 207249 573_1_1 SeqId_17454_15 'EGFL6 chr23:13600242_C_T$SeqId_17454_15 1 chr23:13600242_C_T rs5935624 cis 23 13600242 T C 0.4685 -0.4106 0.0104 6.78e-341 'Epidermal growth factor-like protein 6 ENSG00000198759 'EGFL6 intron_variant ENSG00000198759 ENSG00000198759 'EGFL6 3 novel specific_protein EGFL6 chrX 13569601 13633575 1 25975 protein_coding X:13582123 12522 574_1_1 SeqId_13098_93 'VEGF-D chr23:15436623_A_G$SeqId_13098_93 1 chr23:15436623_A_G rs192812042 cis 23 15436623 A G 0.1324 0.499 0.0149 1.05e-244 'Vascular endothelial growth factor D ENSG00000165197 'FIGF intron_variant ENSG00000165197 ENSG00000165197 'VEGFD 3 novel suggestive_specific_pathway VEGFD chrX 15345596 15384413 -1 2277 protein_coding X:15418500 34087 574_1_1 SeqId_14705_1 'VEGF-D chr23:15436623_A_G$SeqId_14705_1 1 chr23:15436623_A_G rs192812042 cis 23 15436623 A G 0.1324 0.4618 0.0158 5.54e-189 'Vascular endothelial growth factor D ENSG00000165197 'FIGF intron_variant ENSG00000165197 ENSG00000165197 'VEGFD 3 novel suggestive_specific_pathway VEGFD chrX 15345596 15384413 -1 2277 protein_coding X:15418500 34087 574_1_2 SeqId_13634_209 'PIR chr23:15509029_A_G$SeqId_13634_209 1 chr23:15509029_A_G rs925653 cis 23 15509029 A G 0.3482 -0.6428 0.0102 5.11e-865 'Pirin ENSG00000087842 'PIR intron_variant ENSG00000087842 ENSG00000087842 'PIR 3 novel suggestive_specific_pathway PIR chrX 15384799 15493564 -1 8544 protein_coding X:15490906 2658 574_1_3 SeqId_17673_34 'Carbonic Anhydrase VB chr23:15782443_A_G$SeqId_17673_34 1 chr23:15782443_A_G rs5936043 cis 23 15782443 A G 0.6493 0.1208 0.0114 4.05e-26 'Carbonic anhydrase 5B, mitochondrial ENSG00000169239 'CA5B intron_variant ENSG00000169239 ENSG00000169239 'CA5B 3 novel suggestive_specific_pathway CA5B chrX 15688830 15788411 1 11238 protein_coding X:15764320 75490 575_1_1 SeqId_18921_30 'PHEX chr23:22036008_A_G$SeqId_18921_30 1 chr23:22036008_A_G rs5951683 cis 23 22036008 A G 0.6349 0.2265 0.0112 2.82e-90 'Phosphate-regulating neutral endopeptidase ENSG00000102174 'PHEX intergenic_variant ENSG00000102174 ENSG00000102174 'PHEX 3 novel specific_protein PHEX chrX 22032325 22494713 1 5251 protein_coding X:22017890 14435 577_1_1 SeqId_15431_31 'OTCase chr23:38268220_A_G$SeqId_15431_31 1 chr23:38268220_A_G rs1800328 cis 23 38268220 A G 0.9601 0.4014 0.0284 2.0e-45 'Ornithine carbamoyltransferase, mitochondrial ENSG00000036473 'OTC missense_variant ENSG00000036473 ENSG00000036473 'OTC 3 novel specific_protein OTC chrX 38352586 38421446 1 5009 protein_coding X:38408967 56381 58_1_1 SeqId_19360_22 'LRRT1 chr2:80805828_G_T$SeqId_19360_22 1 chr2:80805828_G_T rs17019392_G_T cis 2 80805828 T G 0.0293 0.2897 0.0405 8.9e-13 'Leucine-rich repeat transmembrane neuronal protein 1 ENSG00000162951 'LRRTM1 intron_variant ENSG00000162951 ENSG00000162951 'LRRTM1 3 novel specific_protein LRRTM1 chr2 80288351 80304752 -1 347730 protein_coding 2:80578703 273951 580_1_1 SeqId_9391_60 'PCSK1 chr23:48703186_D_I$SeqId_9391_60 1 chr23:48703186_D_I X:48703186_D_I cis 23 48703186 D I 0.4495 -0.2098 0.0112 1.03e-77 'ProSAAS ENSG00000102109 'PCSK1N intergenic_variant ENSG00000102109 ENSG00000102109 'PCSK1N 3 novel specific_protein PCSK1N chrX 48831096 48835610 -1 27344 protein_coding X:48703186 132424 581_1_1 SeqId_4217_49 'ERAB chr23:53652838_A_G$SeqId_4217_49 1 chr23:53652838_A_G X:53652838_G_A cis 23 53652838 A G 0.4925 -0.077 0.0107 6.79e-13 '3-hydroxyacyl-CoA dehydrogenase type-2 ENSG00000072506 'HSD17B10 intron_variant ENSG00000072506 ENSG00000072506 'HSD17B10 3 novel specific_protein HSD17B10 chrX 53431258 53434370 -1 3028 protein_coding X:53652838 218468 584_1_1 SeqId_13104_32 'EFNB1 chr23:68124544_C_T$SeqId_13104_32 1 chr23:68124544_C_T rs678297 cis 23 68124544 T C 0.5553 -0.0798 0.0107 8.91e-14 'Ephrin-B1 ENSG00000090776 'EFNB1 intergenic_variant ENSG00000090776 ENSG00000090776 'EFNB1 3 novel specific_protein EFNB1 chrX 68829021 68842160 1 1947 protein_coding X:68904701 75680 584_1_2 SeqId_2826_53 'EDA chr23:69243118_A_T$SeqId_2826_53 1 chr23:69243118_A_T rs2274469 cis 23 69243118 A T 0.1435 0.5863 0.0151 8.74e-330 'Ectodysplasin-A, secreted form ENSG00000158813 'EDA intron_variant ENSG00000158813 ENSG00000158813 'EDA 3 novel specific_protein EDA chrX 69616067 70039472 1 1896 protein_coding X:70023268 407201 584_1_3 SeqId_12358_6 'IGBP1 chr23:69402599_A_G$SeqId_12358_6 1 chr23:69402599_A_G rs112058234 cis 23 69402599 A G 0.1461 -0.2157 0.0152 7.54e-46 'Immunoglobulin-binding protein 1 ENSG00000089289 'IGBP1 intron_variant ENSG00000089289 ENSG00000089289 'IGBP1 3 novel unspecific_effect IGBP1 chrX 70133447 70166324 1 3476 protein_coding X:70182749 49302 584_1_4 SeqId_7897_75 'DLG3 chr23:69733949_C_G$SeqId_7897_75 1 chr23:69733949_C_G rs5980712 cis 23 69733949 C G 0.6091 0.4919 0.01 6.14e-528 'Disks large homolog 3 ENSG00000082458 'DLG3 intergenic_variant ENSG00000082458 ENSG00000082458 'DLG3 3 novel specific_protein DLG3 chrX 70444835 70505490 1 1741 protein_coding X:70514099 69264 584_1_5 SeqId_12718_43 'PIN4 chr23:71406301_C_T$SeqId_12718_43 1 chr23:71406301_C_T rs6525591 cis 23 71406301 T C 0.7332 0.3432 0.0112 1.38e-206 'Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 ENSG00000102309 'PIN4 intron_variant ENSG00000102309 ENSG00000102309 'PIN4 3 novel specific_protein PIN4 chrX 72181353 72302926 1 5303 protein_coding X:72186451 5098 586_1_1 SeqId_9090_9 'SYTL4 chr23:99924813_A_G$SeqId_9090_9 1 chr23:99924813_A_G rs2096256 cis 23 99924813 A G 0.6628 0.1747 0.0116 4.68e-51 'Synaptotagmin-like protein 4 ENSG00000102362 'SYTL4 intron_variant ENSG00000102362 ENSG00000102362 'SYTL4 5 novel suggestive_specific_pathway SYTL4 chrX 100671783 100732123 -1 94121 protein_coding X:100669816 62307 586_1_2 SeqId_15588_17 'galactosidase, alpha chr23:100662901_A_G$SeqId_15588_17 1 chr23:100662901_A_G rs2071225 cis 23 100662901 A G 0.0577 -0.639 0.0227 2.08e-174 'Alpha-galactosidase A ENSG00000102393 'GLA 5_prime_UTR_variant ENSG00000102393 ENSG00000102393 'GLA 3 novel specific_protein GLA chrX 101393273 101408012 -1 2717 protein_coding X:101407913 99 587_1_1 SeqId_2706_69 'Thyroxine-Binding Globulin chr23:105291293_A_G$SeqId_2706_69 1 chr23:105291293_A_G rs5916964 cis 23 105291293 A G 0.8837 0.3776 0.0164 1.12e-116 'Thyroxine-binding globulin ENSG00000123561 'SERPINA7 intergenic_variant 0.983479 rs1804495 ENSG00000123561 'SERPINA7 missense_variant ENSG00000123561 ENSG00000123561 'SERPINA7 6 novel suggestive_specific_pathway SERPINA7 chrX 106032435 106038727 -1 6906 protein_coding X:106047302 8575 588_1_1 SeqId_3362_61 'CRDL1 chr23:109739964_C_T$SeqId_3362_61 1 chr23:109739964_C_T rs7876360 cis 23 109739964 T C 0.6116 0.2558 0.0104 2.61e-133 'Chordin-like protein 1 ENSG00000101938 'CHRDL1 intergenic_variant ENSG00000101938 ENSG00000101938 'CHRDL1 5 novel unspecific_effect CHRDL1 chrX 110673856 110795819 -1 91851 protein_coding X:110496736 299083 589_1_1 SeqId_2633_52 'IL-13 Ra1 chr23:117910545_A_T$SeqId_2633_52 1 chr23:117910545_A_T rs3121671 cis 23 117910545 A T 0.831 -0.4071 0.0136 1.4e-196 'Interleukin-13 receptor subunit alpha-1 ENSG00000131724 'IL13RA1 intron_variant ENSG00000131724 ENSG00000131724 'IL13RA1 3 novel specific_protein IL13RA1 chrX 118727133 118794535 1 3597 protein_coding X:118776582 49449 59_1_1 SeqId_4968_50 'CAPG chr2:85629266_C_T$SeqId_4968_50 1 chr2:85629266_C_T rs62623452 cis 2 85629266 T C 0.0146 -1.6459 0.0536 3.09e-207 'Macrophage-capping protein ENSG00000042493 'CAPG start_lost ENSG00000042493 ENSG00000042493 'CAPG 3 known specific_protein -0.87846 0.21676 5.90336994639882e-05 yes CAPG Olink ORGAN DAMAGE(v.3301) CAPG chr2 85394753 85418432 -1 822 protein_coding 2:85402143 16289 59_1_4 SeqId_10672_75 'SP-B chr2:85893741_A_G$SeqId_10672_75 1 chr2:85893741_A_G rs1130866 cis 2 85893741 A G 0.5219 -0.5263 0.0125 2.14e-387 'Pulmonary surfactant-associated protein B ENSG00000168878 'SFTPB missense_variant,splice_region_variant ENSG00000168878 ENSG00000168878 'SFTPB 3 known suggestive_specific_pathway SFTPB chr2 85657314 85668741 -1 6439 protein_coding 2:85666618 2123 59_1_5 SeqId_3195_50 'Granulysin chr2:85934499_A_C$SeqId_3195_50 1 chr2:85934499_A_C rs12151621 cis 2 85934499 A C 0.2246 0.8555 0.0141 5.41e-802 'Granulysin ENSG00000115523 'GNLY TF_binding_site_variant 0.171126 rs11127 ENSG00000115523 'GNLY missense_variant ENSG00000115523 ENSG00000115523 'GNLY 3 known suggestive_specific_pathway 0.49011 0.070066 8.87156012037962e-12 yes GNLY Olink CARDIOMETABOLIC(v.3602) GNLY chr2 85685175 85698852 1 10578 protein_coding 2:85707376 22201 59_1_6 SeqId_12508_9 'CHMP3 chr2:86765100_G_T$SeqId_12508_9 1 chr2:86765100_G_T rs7593151 cis 2 86765100 T G 0.6341 0.1089 0.013 4.39e-17 'Charged multivesicular body protein 3 ENSG00000115561 'CHMP3 intron_variant ENSG00000115561 ENSG00000115561 'CHMP3 3 known specific_protein CHMP3 chr2 86503430 86563479 -1 51652 protein_coding 2:86537977 25502 59_1_7 SeqId_15462_28 'CD8A chr2:87016506_A_G$SeqId_15462_28 1 chr2:87016506_A_G rs3020726 cis 2 87016506 A G 0.8415 -0.3692 0.0173 1.7e-100 'T-cell surface glycoprotein CD8 alpha chain ENSG00000153563 'CD8A synonymous_variant ENSG00000153563 ENSG00000153563 'CD8A 3 known specific_protein -0.67187 0.07729 5.59757601495112e-17 yes CD8A Olink INFLAMMATION(v.3012) CD8A chr2 86784610 86808396 -1 925 protein_coding 2:86789383 19013 59_2_1 SeqId_11516_7 'FABPL chr2:88424066_C_T$SeqId_11516_7 1 chr2:88424066_C_T rs2241883 cis 2 88424066 T C 0.6886 0.1934 0.0141 6.02e-43 'Fatty acid-binding protein, liver ENSG00000163586 'FABP1 missense_variant ENSG00000163586 ENSG00000163586 'FABP1 3 known specific_protein FABP1 chr2 88122982 88128062 -1 2168 protein_coding 2:88124547 3515 59_2_2 SeqId_12333_87 'RPIA chr2:88970680_A_G$SeqId_12333_87 1 chr2:88970680_A_G rs4281908 cis 2 88970680 A G 0.0335 -0.6757 0.0353 1.71e-81 'Ribose-5-phosphate isomerase ENSG00000153574 'RPIA intergenic_variant ENSG00000153574 ENSG00000153574 'RPIA 3 known unspecific_effect RPIA chr2 88691673 88750929 1 22934 protein_coding 2:88671162 20511 59_3_5 SeqId_12509_115 'COMD1 chr2:89412674_A_C$SeqId_12509_115 1 chr2:89412674_A_C rs576480936 trans 2 89412674 A C 0.0185 -0.5062 0.0557 1.05e-19 'COMM domain-containing protein 1 ENSG00000173163 'COMMD1 downstream_gene_variant 0.83674 rs199917475 ENSG00000244116 'IGKV2-28 missense_variant ENSG00000244116 ENSG00000244116 ' 2 known specific_protein COMMD1 chr2 61888724 62147247 1 150684 protein_coding 2:89113183 27224459 590_1_1 SeqId_5735_54 'C1GLC chr23:119760594_A_G$SeqId_5735_54 1 chr23:119760594_A_G rs45557031 cis 23 119760594 A G 0.0236 0.6011 0.0364 2.21e-61 'C1GALT1-specific chaperone 1 ENSG00000171155 'C1GALT1C1 missense_variant ENSG00000171155 ENSG00000171155 'C1GALT1C1 3 novel specific_protein C1GALT1C1 chrX 120625674 120630054 -1 29071 protein_coding X:120626739 3315 591_1_1 SeqId_4567_82 'SH21A chr23:123475290_A_G$SeqId_4567_82 1 chr23:123475290_A_G rs5911814 cis 23 123475290 A G 0.4369 0.1752 0.0114 6.71e-53 'SH2 domain-containing protein 1A ENSG00000183918 'SH2D1A upstream_gene_variant ENSG00000183918 ENSG00000183918 'SH2D1A 3 novel specific_protein SH2D1A chrX 124227868 124373197 1 4068 protein_coding X:124341440 113572 593_1_1 SeqId_3534_14 'CD40 ligand, soluble chr23:135741443_A_G$SeqId_3534_14 1 chr23:135741443_A_G rs148594123 cis 23 135741443 A G 0.0192 -0.4693 0.0396 1.96e-32 'CD40 ligand ENSG00000102245 'CD40LG missense_variant ENSG00000102245 ENSG00000102245 'CD40LG 3 known specific_protein CD40LG chrX 136648158 136660390 1 959 protein_coding X:136659284 11126 594_1_1 SeqId_5307_12 'Coagulation Factor IXab chr23:138646842_D_I$SeqId_5307_12 1 chr23:138646842_D_I rs35633927 cis 23 138646842 D I 0.7937 -0.1211 0.0145 5.46e-17 'Coagulation factor IXab ENSG00000101981 'F9 downstream_gene_variant 0.547624 rs6048 ENSG00000101981 'F9 missense_variant ENSG00000101981 ENSG00000101981 'F9 3 novel unspecific_effect F9 chrX 139530739 139563459 1 2158 protein_coding X:139564684 33945 595_1_1 SeqId_7139_14 'SLIK4 chr23:142679923_A_G$SeqId_7139_14 1 chr23:142679923_A_G X:142679923_G_A cis 23 142679923 A G 0.2923 0.1587 0.0109 7.4e-48 'SLIT and NTRK-like protein 4 ENSG00000179542 'SLITRK4 intergenic_variant ENSG00000179542 ENSG00000179542 'SLITRK4 3 novel specific_protein SLITRK4 chrX 143622790 143636101 -1 139065 protein_coding X:142679923 956178 597_1_1 SeqId_16922_53 'PLXB3 chr23:153031840_C_G$SeqId_16922_53 1 chr23:153031840_C_G X:153031840_G_C cis 23 153031840 C G 0.1486 0.1462 0.0163 3.3e-19 'Plexin-B3 ENSG00000198753 'PLXNB3 intron_variant 0.130014 rs2266879 ENSG00000198753 'PLXNB3 missense_variant ENSG00000198753 ENSG00000198753 'PLXNB3 3 novel specific_protein PLXNB3 chrX 153764196 153779346 1 5365 protein_coding X:153031840 732356 598_1_1 SeqId_19357_11 'VAMP7 chr23:155137183_D_I$SeqId_19357_11 1 chr23:155137183_D_I X:155137183_I_D cis 23 155137183 D I 0.5619 0.1387 0.0154 2.56e-19 'Vesicle-associated membrane protein 7 ENSG00000124333 'VAMP7 intron_variant ENSG00000124333 ENSG00000124333 'VAMP7 3 novel specific_protein VAMP7 chrX 155881345 155943769 1 6845 protein_coding X:155137183 744162 6_1_1 SeqId_13236_25 'WNT3A chr1:21820042_A_G$SeqId_13236_25 1 chr1:21820042_A_G rs12132412 trans 1 21820042 A G 0.6057 0.1043 0.014 1.04e-13 'Protein Wnt-3a ENSG00000154342 'WNT3A intergenic_variant 0.32731 rs3820293 ENSG00000142794 'NBPF3 missense_variant ENSG00000162552 ENSG00000162552 'WNT4 2 novel unspecific_effect WNT3A chr1 228006998 228061271 1 89780 protein_coding 1:21493549 206513449 6_1_3 SeqId_15626_223 'Perlecan chr1:22180723_C_T$SeqId_15626_223 1 chr1:22180723_C_T rs12742444 cis 1 22180723 T C 0.0572 0.5402 0.0288 2.19e-78 'Basement membrane-specific heparan sulfate proteoglycan core protein ENSG00000142798 'HSPG2 synonymous_variant 0.99395 rs35669711 ENSG00000142798 'HSPG2 missense_variant ENSG00000142798 ENSG00000142798 'HSPG2 3 novel specific_protein 0.32632 0.13376 0.0150660706618674 yes PLC Olink CARDIOVASCULAR III(v.6112) HSPG2 chr1 21822244 21937310 -1 3339 protein_coding 1:21854230 83080 6_1_4 SeqId_11192_168 'TINAL chr1:22182115_A_G$SeqId_11192_168 1 chr1:22182115_A_G rs2229474 trans 1 22182115 A G 0.0119 0.6113 0.0609 1.09e-23 'Tubulointerstitial nephritis antigen-like ENSG00000142910 'TINAGL1 missense_variant ENSG00000142798 ENSG00000142798 'HSPG2 3 novel suggestive_specific_pathway TINAGL1 chr1 31576485 31587686 1 64129 protein_coding 1:21855622 9720863 6_1_5 SeqId_6385_63 'VWA1 chr1:22200998_C_T$SeqId_6385_63 1 chr1:22200998_C_T rs2229481 trans 1 22200998 T C 0.0301 -0.3918 0.0397 5.32e-23 'von Willebrand factor A domain-containing protein 1 ENSG00000179403 'VWA1 missense_variant ENSG00000142798 ENSG00000142798 'HSPG2 5 novel specific_protein VWA1 chr1 1434861 1442882 1 64856 protein_coding 1:21874505 20439644 6_1_6 SeqId_14100_63 'C1QC chr1:22989532_C_T$SeqId_14100_63 1 chr1:22989532_C_T rs75380810 cis 1 22989532 T C 0.9626 -0.9639 0.0347 1.38e-169 'Complement C1q subcomponent subunit C ENSG00000159189 'C1QC downstream_gene_variant ENSG00000159189 ENSG00000159189 'C1QC 3 known suggestive_specific_pathway C1QC chr1 22643633 22648110 1 714 protein_coding 1:22663039 19406 6_1_7 SeqId_8225_86 'EPHB2 chr1:23061958_A_C$SeqId_8225_86 1 chr1:23061958_A_C rs2043970 cis 1 23061958 A C 0.9223 0.5814 0.0229 2.47e-142 'Ephrin type-B receptor 2 ENSG00000133216 'EPHB2 intron_variant ENSG00000133216 ENSG00000133216 'EPHB2 3 known suggestive_specific_pathway EPHB2 chr1 22710839 22921500 1 2048 protein_coding 1:22735465 24626 60_1_3 SeqId_12333_87 'RPIA chr2:92324139_A_T$SeqId_12333_87 1 chr2:92324139_A_T 2:92324139_T_A trans 2 92324139 A T 0.0823 0.1823 0.0263 4.25e-12 'Ribose-5-phosphate isomerase ENSG00000153574 'RPIA intergenic_variant 0.721223 rs6760987 ENSG00000241244 'IGKV1D-16 missense_variant none none ' known specific_protein RPIA chr2 88691673 88750929 1 22934 protein_coding 2:92136113 3444440 61_1_3 SeqId_8013_9 'LMA2L chr2:97405440_A_G$SeqId_8013_9 1 chr2:97405440_A_G rs2271893 cis 2 97405440 A G 0.3188 0.1314 0.0136 4.6e-22 'VIP36-like protein ENSG00000114988 'LMAN2L intron_variant ENSG00000114988 ENSG00000114988 'LMAN2L 3 known specific_protein LMAN2L chr2 96705929 96740064 -1 81562 protein_coding 2:96739703 361 62_1_1 SeqId_14133_93 'IL-1 sRII chr2:102616154_G_T$SeqId_14133_93 1 chr2:102616154_G_T rs2310170 cis 2 102616154 T G 0.6058 0.4365 0.0128 4.59e-255 'Interleukin-1 receptor type 2 ENSG00000115590 'IL1R2 intron_variant ENSG00000115590 ENSG00000115590 'IL1R2 3 known unspecific_effect 0.56148 0.05508 3.11888958409394e-22 yes IL-1RT2 Olink CARDIOVASCULAR III(v.6112) IL1R2 chr2 101991960 102028544 1 7850 protein_coding 2:101999692 7732 62_2_1 SeqId_2991_9 'IL-1 sRI chr2:102774054_A_G$SeqId_2991_9 1 chr2:102774054_A_G rs2287047 cis 2 102774054 A G 0.293 -0.1304 0.0142 5.49e-20 'Interleukin-1 receptor type 1 ENSG00000115594 'IL1R1 intron_variant ENSG00000115594 ENSG00000115594 'IL1R1 3 known unspecific_effect IL1R1 chr2 102064544 102179874 1 3554 protein_coding 2:102157594 93050 62_2_2 SeqId_2994_71 'IL-1Rrp2 chr2:102778461_C_T$SeqId_2994_71 1 chr2:102778461_C_T rs3917265 cis 2 102778461 T C 0.4613 0.256 0.0134 8.95e-82 'Interleukin-1 receptor-like 2 ENSG00000115598 'IL1RL2 intron_variant ENSG00000115598 ENSG00000115598 'IL1RL2 3 known suggestive_specific_pathway 0.3629 0.063097 1.57470787728985e-08 yes IL1RL2 Olink CARDIOVASCULAR II(v.5004) IL1RL2 chr2 102187006 102240002 1 8808 protein_coding 2:102162001 25005 62_2_3 SeqId_4234_8 'IL-1 R4 chr2:102921783_G_T$SeqId_4234_8 1 chr2:102921783_G_T rs10179654 cis 2 102921783 T G 0.4779 0.7333 0.0102 5.29e-1125 'Interleukin-1 receptor-like 1 ENSG00000115602 'IL1RL1 regulatory_region_variant 0.260981 rs1041973 ENSG00000115602 'IL1RL1 missense_variant ENSG00000115602 ENSG00000115602 'IL1RL1 3 known suggestive_specific_pathway 0.59636 0.050754 3.26587832172335e-28 yes ST2 Olink CARDIOVASCULAR III(v.6112) IL1RL1 chr2 102311502 102352037 1 9173 protein_coding 2:102305323 6179 62_2_4 SeqId_14079_14 'IL-18 Ra chr2:102982876_C_T$SeqId_14079_14 1 chr2:102982876_C_T rs1573895 cis 2 102982876 T C 0.2295 0.6408 0.014 2.05e-457 'Interleukin-18 receptor 1 ENSG00000115604 'IL18R1 intron_variant ENSG00000115604 ENSG00000115604 'IL18R1 3 known specific_pathway 0.83989 0.068662 3.8018939632056e-30 yes IL-18R1 Olink INFLAMMATION(v.3012) IL18R1 chr2 102311529 102398777 1 8809 protein_coding 2:102366416 54887 62_2_5 SeqId_2993_1 'IL-18 Rb chr2:103016043_D_I$SeqId_2993_1 1 chr2:103016043_D_I rs112223498 cis 2 103016043 D I 0.3139 0.1423 0.0143 2.92e-23 'Interleukin-18 receptor accessory protein ENSG00000115607 'IL18RAP downstream_gene_variant ENSG00000115607 ENSG00000115607 'IL18RAP 3 known specific_pathway IL18RAP chr2 102418689 102452565 1 8807 protein_coding 2:102399584 19105 63_1_1 SeqId_8258_22 'UXS1 chr2:106805671_D_I$SeqId_8258_22 1 chr2:106805671_D_I rs76465958 cis 2 106805671 D I 0.9229 -0.2314 0.0243 2.03e-21 'UDP-glucuronic acid decarboxylase 1 ENSG00000115652 'UXS1 intron_variant ENSG00000115652 ENSG00000115652 'UXS1 3 known specific_protein UXS1 chr2 106093308 106194301 -1 80146 protein_coding 2:106189216 5085 64_1_1 SeqId_17811_78 'ST1C2 chr2:108882824_A_G$SeqId_17811_78 1 chr2:108882824_A_G rs7586308 cis 2 108882824 A G 0.194 0.1169 0.0171 8.14e-12 'Sulfotransferase 1C2 ENSG00000198203 'SULT1C2 downstream_gene_variant ENSG00000198203 ENSG00000198203 'SULT1C2 3 novel specific_protein SULT1C2 chr2 108288639 108309915 1 6819 protein_coding 2:108266368 22271 64_1_3 SeqId_2977_7 'EDAR chr2:109600755_A_G$SeqId_2977_7 1 chr2:109600755_A_G rs75147553 cis 2 109600755 A G 0.0137 1.8569 0.0539 5.22e-260 'Tumor necrosis factor receptor superfamily member EDAR ENSG00000135960 'EDAR intron_variant ENSG00000135960 ENSG00000135960 'EDAR 3 known specific_protein 1.8322 0.22886 8.91250938133744e-15 yes EDAR Olink IMMUNE RESPONSE(v.3202) EDAR chr2 108894471 108989372 -1 10913 protein_coding 2:108984299 5073 66_1_1 SeqId_5353_89 'IL-1Ra chr2:113867288_C_T$SeqId_5353_89 1 chr2:113867288_C_T rs55709272 cis 2 113867288 T C 0.5647 0.212 0.0135 1.33e-55 'Interleukin-1 receptor antagonist protein ENSG00000136689 'IL1RN upstream_gene_variant ENSG00000136689 ENSG00000136689 'IL1RN 5 known specific_pathway 0.20616 0.063593 0.00126969672678094 yes IL-1ra Olink CARDIOVASCULAR II(v.5004) IL1RN chr2 113107214 113134016 1 3557 protein_coding 2:113109711 2497 66_1_1 SeqId_2991_9 'IL-1 sRI chr2:113841030_A_G$SeqId_2991_9 1 chr2:113841030_A_G rs6734238 trans 2 113841030 A G 0.5979 -0.1066 0.0132 6.5e-16 'Interleukin-1 receptor type 1 ENSG00000115594 'IL1R1 upstream_gene_variant 0.135386 rs6761276 ENSG00000136697 'IL1F10 missense_variant ENSG00000115008|ENSG00000125538|ENSG00000125571|ENSG00000136689|ENSG00000136694|ENSG00000136695|ENSG00000136696 ENSG00000136689 'IL1RN 5 known specific_pathway IL1R1 chr2 102064544 102179874 1 3554 protein_coding 2:113083453 11018909 66_1_2 SeqId_13973_62 'TTL chr2:113205116_C_T$SeqId_13973_62 1 chr2:113205116_C_T rs142185492 cis 2 113205116 T C 0.0822 0.1933 0.0233 1.11e-16 'Tubulin--tyrosine ligase ENSG00000114999 'TTL intergenic_variant ENSG00000114999 ENSG00000114999 'TTL 3 novel specific_protein TTL chr2 112482156 112541739 1 150465 protein_coding 2:112447539 34617 67_1_1 SeqId_16919_1 'ACBP chr2:120142939_C_G$SeqId_16919_1 1 chr2:120142939_C_G rs6733335 cis 2 120142939 C G 0.7976 0.3549 0.0149 5.27e-125 'Acyl-CoA-binding protein ENSG00000155368 'DBI regulatory_region_variant 0.95688 rs3731608 ENSG00000155368 'DBI stop_gained ENSG00000155368 ENSG00000155368 'DBI 5 novel suggestive_specific_pathway DBI chr2 119366924 119372550 1 1622 protein_coding 2:119385363 18439 67_1_2 SeqId_18432_32 'RALB chr2:121025601_C_T$SeqId_18432_32 1 chr2:121025601_C_T rs6722943 cis 2 121025601 T C 0.6931 -0.2262 0.0142 1.93e-57 'Ras-related protein Ral-B ENSG00000144118 'RALB intron_variant ENSG00000144118 ENSG00000144118 'RALB 6 novel specific_pathway RALB chr2 120240064 120294710 1 5899 protein_coding 2:120268025 27961 67_2_1 SeqId_13676_46 'Inhibin bB chain chr2:121306440_A_G$SeqId_13676_46 1 chr2:121306440_A_G rs17050272 cis 2 121306440 A G 0.4163 0.3017 0.0132 4.18e-115 'Inhibin beta B chain ENSG00000163083 'INHBB upstream_gene_variant ENSG00000163083 ENSG00000163083 'INHBB 3 novel specific_protein INHBB chr2 120346136 120351803 1 3625 protein_coding 2:120548864 202728 68_1_1 SeqId_9574_11 'BIN1 chr2:127882182_C_T$SeqId_9574_11 1 chr2:127882182_C_T rs35103166 cis 2 127882182 T C 0.6232 -0.2209 0.0133 1.63e-61 'Myc box-dependent-interacting protein 1 ENSG00000136717 'BIN1 intergenic_variant ENSG00000136717 ENSG00000136717 'BIN1 3 known specific_protein BIN1 chr2 127048027 127107288 -1 274 protein_coding 2:127124606 17318 68_2_1 SeqId_2961_1 'Protein C chr2:128176040_A_T$SeqId_2961_1 1 chr2:128176040_A_T rs1799810 cis 2 128176040 A T 0.573 0.1574 0.0134 7.69e-32 'Vitamin K-dependent protein C ENSG00000115718 'PROC 5_prime_UTR_variant ENSG00000115718 ENSG00000115718 'PROC 3 known specific_protein 0.27514 0.062871 1.48013047302082e-05 yes PROC Olink CARDIOMETABOLIC(v.3602) PROC chr2 127418427 127429242 1 5624 protein_coding 2:127418464 37 68_2_2 SeqId_5465_32 'H6ST1 chr2:129065971_C_T$SeqId_5465_32 1 chr2:129065971_C_T rs13010149 cis 2 129065971 T C 0.2161 -0.2811 0.0156 2.8e-72 'Heparan-sulfate 6-O-sulfotransferase 1 ENSG00000136720 'HS6ST1 intron_variant ENSG00000136720 ENSG00000136720 'HS6ST1 3 known specific_protein -0.24544 0.080464 0.00241212605609257 yes HS6ST1 Olink CELL REGULATION(v.3701) HS6ST1 chr2 128236716 128318868 -1 9394 protein_coding 2:128308397 10471 69_2_1 SeqId_12675_14 'SYDC chr2:136561557_A_G$SeqId_12675_14 1 chr2:136561557_A_G rs2304371 cis 2 136561557 A G 0.8473 -0.1585 0.0179 8.11e-19 'Aspartate--tRNA ligase, cytoplasmic ENSG00000115866 'DARS synonymous_variant ENSG00000115866 ENSG00000115866 'DARS1 3 known suggestive_specific_pathway DARS1 chr2 135905881 135986100 -1 1615 protein_coding 2:135803987 182113 69_2_2 SeqId_9017_58 'LPH chr2:136608646_A_G$SeqId_9017_58 1 chr2:136608646_A_G rs4988235 cis 2 136608646 A G 0.6929 0.8821 0.0108 2.57e-1451 'Lactase-phlorizin hydrolase ENSG00000115850 'LCT intron_variant 0.651059 rs2322659 ENSG00000115850 'LCT missense_variant ENSG00000115850 ENSG00000115850 'LCT 3 known unspecific_effect LCT chr2 135787850 135837184 -1 3938 protein_coding 2:135851076 13892 7_1_1 SeqId_10569_28 'MFAP2 chr1:25291697_C_T$SeqId_10569_28 1 chr1:25291697_C_T rs188468174 none 1 25291697 T C 0.0136 0.4715 0.0593 1.79e-15 'Microfibrillar-associated protein 2 upstream_gene_variant ENSG00000020633 ENSG00000020633 'RUNX3 2 novel unspecific_effect MFAP2 chr1 16974502 16980632 -1 4237 protein_coding 1:24965206 7984574 7_1_1 SeqId_3293_2 'CD5L chr1:25291697_C_T$SeqId_3293_2 1 chr1:25291697_C_T rs188468174 trans 1 25291697 T C 0.0136 0.7743 0.0601 5.83e-38 'CD5 antigen-like ENSG00000073754 'CD5L upstream_gene_variant ENSG00000020633 ENSG00000020633 'RUNX3 2 novel unspecific_effect CD5L chr1 157830911 157898256 -1 922 protein_coding 1:24965206 132933050 7_1_1 SeqId_5487_7 'SLAF7 chr1:25291697_C_T$SeqId_5487_7 1 chr1:25291697_C_T rs188468174 trans 1 25291697 T C 0.0136 -0.6202 0.0598 3.62e-25 'SLAM family member 7 ENSG00000026751 'SLAMF7 upstream_gene_variant ENSG00000020633 ENSG00000020633 'RUNX3 2 novel unspecific_effect SLAMF7 chr1 160739057 160754821 1 57823 protein_coding 1:24965206 135773851 7_1_1 SeqId_6264_9 'CYR61 chr1:25298841_C_T$SeqId_6264_9 1 chr1:25298841_C_T rs16830188 trans 1 25298841 T C 0.0222 -0.3228 0.047 6.67e-12 'Protein CYR61 ENSG00000142871 'CYR61 upstream_gene_variant ENSG00000261025|ENSG00000020633|ENSG00000142677|ENSG00000157978 ENSG00000020633 'RUNX3 2 novel unspecific_effect CCN1 chr1 85580761 85584589 1 3491 protein_coding 1:24972350 60608411 7_1_2 SeqId_7192_37 'CRF2-12 chr1:24513723_C_G$SeqId_7192_37 1 chr1:24513723_C_G rs139958347 cis 1 24513723 C G 0.0404 -0.4795 0.038 1.94e-36 'Interferon lambda receptor 1 ENSG00000185436 'IFNLR1 missense_variant ENSG00000185436 ENSG00000185436 'IFNLR1 3 known specific_protein -0.9527 0.16166 7.10231614300866e-09 yes IFNLR1 Olink IMMUNE RESPONSE(v.3202) IFNLR1 chr1 24154168 24187959 -1 163702 protein_coding 1:24187233 726 7_2_3 SeqId_18183_3 'ARH chr1:25877492_C_T$SeqId_18183_3 1 chr1:25877492_C_T rs75446219 cis 1 25877492 T C 0.031 0.3896 0.0384 3.85e-24 'Low density lipoprotein receptor adapter protein 1 ENSG00000157978 'LDLRAP1 intron_variant ENSG00000157978 ENSG00000157978 'LDLRAP1 3 novel unspecific_effect LDLRAP1 chr1 25543606 25568886 1 26119 protein_coding 1:25551001 7395 7_2_4 SeqId_13427_66 'MA1C1 chr1:26097731_C_T$SeqId_13427_66 1 chr1:26097731_C_T rs2072748 cis 1 26097731 T C 0.5092 -0.251 0.0134 6.95e-78 'Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC ENSG00000117643 'MAN1C1 intron_variant ENSG00000117643 ENSG00000117643 'MAN1C1 3 known unspecific_effect MAN1C1 chr1 25616791 25786206 1 57134 protein_coding 1:25771240 154449 7_2_5 SeqId_17490_4 'SH3BGRL3-like protein chr1:26622993_C_T$SeqId_17490_4 1 chr1:26622993_C_T rs4659424 cis 1 26622993 T C 0.0666 -0.6441 0.0245 4.67e-152 'SH3 domain-binding glutamic acid-rich-like protein 3 ENSG00000142669 'SH3BGRL3 intron_variant ENSG00000142669 ENSG00000142669 'SH3BGRL3 3 novel specific_protein SH3BGRL3 chr1 26280086 26281522 1 83442 protein_coding 1:26296502 16416 7_2_6 SeqId_12329_21 'KS6A1 chr1:26860999_A_G$SeqId_12329_21 1 chr1:26860999_A_G rs11589734 cis 1 26860999 A G 0.5424 0.1845 0.0133 1.92e-43 'Ribosomal protein S6 kinase alpha-1 ENSG00000117676 'RPS6KA1 intron_variant 0.245166 rs2229712 ENSG00000117676 'RPS6KA1 missense_variant ENSG00000117676 ENSG00000117676 'RPS6KA1 3 novel suggestive_specific_pathway RPS6KA1 chr1 26529761 26575030 1 6195 protein_coding 1:26534508 4747 7_3_1 SeqId_4706_17 '41 chr1:29202162_C_T$SeqId_4706_17 1 chr1:29202162_C_T rs7556059 cis 1 29202162 T C 0.0678 -0.1842 0.0252 2.45e-13 'Protein 4.1 ENSG00000159023 'EPB41 intron_variant,non_coding_transcript_variant ENSG00000159023 ENSG00000159023 'EPB41 5 novel specific_pathway EPB41 chr1 28887091 29120046 1 2035 protein_coding 1:28875650 11441 7_3_3 SeqId_5462_62 'Ficolin-3 chr1:27699670_D_I$SeqId_5462_62 1 chr1:27699670_D_I rs532781899 cis 1 27699670 D I 0.0161 -1.5449 0.0531 7.29e-186 'Ficolin-3 ENSG00000142748 'FCN3 frameshift_variant ENSG00000142748 ENSG00000142748 'FCN3 3 known suggestive_specific_pathway FCN3 chr1 27369110 27374824 -1 8547 protein_coding 1:27373180 1644 7_3_4 SeqId_3810_50 'FGR chr1:27960792_A_G$SeqId_3810_50 1 chr1:27960792_A_G rs3737803 cis 1 27960792 A G 0.0739 -0.499 0.0249 1.89e-89 'Tyrosine-protein kinase Fgr ENSG00000000938 'FGR intron_variant ENSG00000000938 ENSG00000000938 'FGR 3 known unspecific_effect -0.40068 0.1135 0.00045519763814842 yes FGR Olink ORGAN DAMAGE(v.3301) FGR chr1 27612064 27635185 -1 2268 protein_coding 1:27634281 904 7_3_5 SeqId_8337_65 'PTPRU chr1:29633491_D_I$SeqId_8337_65 1 chr1:29633491_D_I rs3835409 cis 1 29633491 D I 0.6766 0.1457 0.0144 3.29e-24 'Receptor-type tyrosine-protein phosphatase U ENSG00000060656 'PTPRU intron_variant ENSG00000060656 ENSG00000060656 'PTPRU 3 known specific_protein PTPRU chr1 29236516 29326813 1 10076 protein_coding 1:29306980 70464 70_1_1 SeqId_4559_64 'KYNU chr2:143801205_A_C$SeqId_4559_64 1 chr2:143801205_A_C rs73961713 cis 2 143801205 A C 0.1727 -0.7857 0.0161 1.16e-519 'Kynureninase ENSG00000115919 'KYNU downstream_gene_variant 0.994606 rs9013 ENSG00000115919 'KYNU missense_variant ENSG00000115919 ENSG00000115919 'KYNU 3 known specific_protein -0.20522 0.07602 0.0071878664606888 yes KYNU Olink NEUROLOGY(v.8011) KYNU chr2 142877657 143055833 1 8942 protein_coding 2:143043636 165979 71_1_1 SeqId_5036_50 'TSG-6 chr2:152146672_G_T$SeqId_5036_50 1 chr2:152146672_G_T rs2278089 cis 2 152146672 T G 0.6115 -0.3184 0.0128 1.15e-135 'Tumor necrosis factor-inducible gene 6 protein ENSG00000123610 'TNFAIP6 upstream_gene_variant ENSG00000123610 ENSG00000123610 'TNFAIP6 3 known specific_protein TNFAIP6 chr2 151357592 151380046 1 7130 protein_coding 2:151290158 67434 72_1_2 SeqId_16620_26 'LY75 chr2:160726544_G_T$SeqId_16620_26 1 chr2:160726544_G_T rs17231342 cis 2 160726544 T G 0.5435 -0.788 0.011 4.98e-1117 'Lymphocyte antigen 75 ENSG00000054219 'LY75 intron_variant ENSG00000054219 ENSG00000054219 'LY75 3 known suggestive_specific_pathway -0.70014 0.055087 3.8904514499428e-32 yes LY75 Olink IMMUNE RESPONSE(v.3202) LY75 chr2 159803355 159904756 -1 4065 protein_coding 2:159870033 34723 72_1_4 SeqId_10916_44 'PLA2R chr2:160885442_C_T$SeqId_10916_44 1 chr2:160885442_C_T rs3749117 cis 2 160885442 T C 0.5041 0.6237 0.0117 1.27e-619 'Secretory phospholipase A2 receptor ENSG00000153246 'PLA2R1 missense_variant ENSG00000153246 ENSG00000153246 'PLA2R1 3 known unspecific_effect PLA2R1 chr2 159932006 160062615 -1 22925 protein_coding 2:160028931 33684 72_2_2 SeqId_5029_3 'SEPR chr2:163073082_C_T$SeqId_5029_3 1 chr2:163073082_C_T rs16846387 cis 2 163073082 T C 0.9898 -1.1219 0.0663 3.69e-64 'Prolyl endopeptidase FAP ENSG00000078098 'FAP intron_variant ENSG00000078098 ENSG00000078098 'FAP 3 known specific_protein -1.0557 0.29515 0.000383001081226449 yes FAP Olink CARDIOMETABOLIC(v.3602) FAP chr2 162170684 162245151 -1 2191 protein_coding 2:162216572 28579 72_2_4 SeqId_12594_5 'GRAN chr2:163208893_G_T$SeqId_12594_5 1 chr2:163208893_G_T rs17783344 cis 2 163208893 T G 0.8561 0.586 0.0191 6.54e-207 'Grancalcin ENSG00000115271 'GCA missense_variant ENSG00000115271 ENSG00000115271 'GCA 3 known specific_protein GCA chr2 162318840 162371595 1 25801 protein_coding 2:162352383 33543 73_1_1 SeqId_5227_60 'PDK1 chr2:173402900_C_T$SeqId_5227_60 1 chr2:173402900_C_T rs7584089 cis 2 173402900 T C 0.1946 -0.7091 0.0147 8.62e-508 '[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial ENSG00000152256 'PDK1 intron_variant ENSG00000152256 ENSG00000152256 'PDK1 3 known specific_protein PDK1 chr2 172555373 172608669 1 5163 protein_coding 2:172538172 17201 74_1_1 SeqId_12659_13 'GTPB9 chr2:174998510_D_I$SeqId_12659_13 1 chr2:174998510_D_I rs138847619 cis 2 174998510 D I 0.1946 0.1529 0.0158 3.47e-22 'Obg-like ATPase 1 ENSG00000138430 'OLA1 intron_variant 0.974153 rs11558990 ENSG00000138430 'OLA1 missense_variant ENSG00000138430 ENSG00000138430 'OLA1 3 known specific_protein OLA1 chr2 174072447 174248599 -1 29789 protein_coding 2:174133783 114816 75_1_1 SeqId_4430_44 'Collectin Kidney 1 chr2:180726678_D_I$SeqId_4430_44 1 chr2:180726678_D_I rs11362683 trans 2 180726678 D I 0.3776 0.1209 0.0142 2.08e-17 'Collectin-11 ENSG00000118004 'COLEC11 upstream_gene_variant ENSG00000144331 ENSG00000144331 'ZNF385B 1 known unspecific_effect COLEC11 chr2 3594832 3644644 1 78989 protein_coding 2:179861952 176267120 75_1_2 SeqId_9288_7 'FKBP7 chr2:179341953_A_G$SeqId_9288_7 1 chr2:179341953_A_G rs6704545 cis 2 179341953 A G 0.1931 0.459 0.0154 5.27e-195 'Peptidyl-prolyl cis-trans isomerase FKBP7 ENSG00000079150 'FKBP7 intron_variant ENSG00000079150 ENSG00000079150 'FKBP7 3 known specific_protein 0.24258 0.082373 0.00338688148563477 yes FKBP7 Olink NEURO EXPLORATORY(v.3901) FKBP7 chr2 178463664 178478600 -1 51661 protein_coding 2:178477226 1374 77_1_1 SeqId_8297_8 'DJC10 chr2:183627183_C_T$SeqId_8297_8 1 chr2:183627183_C_T rs72898732 cis 2 183627183 T C 0.0241 -0.3336 0.0423 3.28e-15 'DnaJ homolog subfamily C member 10 ENSG00000077232 'DNAJC10 intron_variant ENSG00000077232 ENSG00000077232 'DNAJC10 3 novel specific_protein DNAJC10 chr2 182716255 182794464 1 54431 protein_coding 2:182762456 46201 77_1_2 SeqId_13740_51 'sFRP-3 chr2:183703336_A_G$SeqId_13740_51 1 chr2:183703336_A_G rs288326 cis 2 183703336 A G 0.1228 0.6002 0.0198 4.67e-201 'Secreted frizzled-related protein 3 ENSG00000162998 'FRZB missense_variant ENSG00000162998 ENSG00000162998 'FRZB 3 known specific_protein 0.78605 0.084118 3.47536161443206e-19 yes sFRP-3 Olink NEUROLOGY(v.8011) FRZB chr2 182833275 182866637 -1 2487 protein_coding 2:182838608 28029 78_1_2 SeqId_8786_6 'F171B chr2:187642459_A_C$SeqId_8786_6 1 chr2:187642459_A_C rs76851721 cis 2 187642459 A C 0.7778 0.208 0.0159 5.65e-39 'Protein FAM171B ENSG00000144369 'FAM171B intergenic_variant ENSG00000144369 ENSG00000144369 'FAM171B 3 known specific_protein FAM171B chr2 186694060 186765959 1 165215 protein_coding 2:186777732 83672 78_1_3 SeqId_3336_50 'TFPI chr2:188324459_C_T$SeqId_3336_50 1 chr2:188324459_C_T rs116011690 cis 2 188324459 T C 0.0227 -0.3732 0.0423 1.05e-18 'Tissue factor pathway inhibitor ENSG00000003436 'TFPI downstream_gene_variant 0.997492 rs5940 ENSG00000003436 'TFPI missense_variant ENSG00000003436 ENSG00000003436 'TFPI 3 novel suggestive_specific_pathway TFPI chr2 187464230 187565760 -1 7035 protein_coding 2:187459732 106028 79_1_2 SeqId_12396_19 'HIBCH chr2:191199530_A_G$SeqId_12396_19 1 chr2:191199530_A_G rs291431 cis 2 191199530 A G 0.5942 0.2423 0.0126 3.1e-82 '3-hydroxyisobutyryl-CoA hydrolase, mitochondrial ENSG00000198130 'HIBCH intron_variant 0.988167 rs291466 ENSG00000198130 'HIBCH start_lost ENSG00000198130 ENSG00000198130 'HIBCH 3 known specific_protein HIBCH chr2 190189735 190344193 -1 26275 protein_coding 2:190334804 9389 8_1_1 SeqId_13969_24 'IMA7 chr1:32462654_G_T$SeqId_13969_24 1 chr1:32462654_G_T rs72666722 cis 1 32462654 T G 0.0226 0.5818 0.0447 9.64e-39 'Importin subunit alpha-7 ENSG00000025800 'KPNA6 intergenic_variant ENSG00000025800 ENSG00000025800 'KPNA6 3 novel specific_protein KPNA6 chr1 32108056 32176563 1 23633 protein_coding 1:31997053 111003 81_1_1 SeqId_15387_44 'Neuropilin-2 chr2:205994522_A_G$SeqId_15387_44 1 chr2:205994522_A_G rs12465268 trans 2 205994522 A G 0.2351 -0.1987 0.0151 1.26e-39 'Neuropilin-2 ENSG00000118257 'NRP2 intron_variant 0.162704 rs2289025 ENSG00000116117 'PARD3B missense_variant ENSG00000118257 ENSG00000118257 'NRP2 4 novel specific_protein -0.19297 0.070515 0.00643872682901462 yes NRP2 Olink NEUROLOGY(v.8011) NRP2 chr2 205681990 205798133 1 8828 protein_coding 2:205129798 552192 81_2_2 SeqId_7049_2 'ADAM 23 chr2:207313203_C_G$SeqId_7049_2 1 chr2:207313203_C_G rs1207146 cis 2 207313203 C G 0.6789 0.3781 0.0134 5.97e-174 'Disintegrin and metalloproteinase domain-containing protein 23 ENSG00000114948 'ADAM23 intron_variant ENSG00000114948 ENSG00000114948 'ADAM23 3 known suggestive_specific_pathway 0.39607 0.066616 5.30517848880898e-09 yes ADAM 23 Olink NEUROLOGY(v.8011) ADAM23 chr2 206443532 206621127 1 8745 protein_coding 2:206448479 4947 82_1_1 SeqId_12366_16 'CRGD chr2:208977161_C_T$SeqId_12366_16 1 chr2:208977161_C_T rs11690925 cis 2 208977161 T C 0.2912 -0.295 0.0148 3.49e-88 'Gamma-crystallin D ENSG00000118231 'CRYGD non_coding_transcript_exon_variant ENSG00000118231 ENSG00000118231 'CRYGD 3 novel specific_protein CRYGD chr2 208121607 208124524 -1 1421 protein_coding 2:208112437 12087 82_1_2 SeqId_18338_26 'IDH chr2:209108301_C_T$SeqId_18338_26 1 chr2:209108301_C_T rs34599179 cis 2 209108301 T C 0.9865 0.5901 0.0539 6.72e-28 'Isocitrate dehydrogenase [NADP] cytoplasmic ENSG00000138413 'IDH1 missense_variant ENSG00000138413 ENSG00000138413 'IDH1 3 novel specific_protein IDH1 chr2 208236229 208266074 -1 3417 protein_coding 2:208243577 22497 83_1_1 SeqId_12646_2 'RPE chr2:211060050_G_T$SeqId_12646_2 1 chr2:211060050_G_T rs2286963 cis 2 211060050 T G 0.6496 0.115 0.0135 1.32e-17 'Ribulose-phosphate 3-epimerase ENSG00000197713 'RPE missense_variant ENSG00000197713 ENSG00000197713 'RPE 3 novel specific_protein RPE chr2 210002565 210022260 1 6120 protein_coding 2:210195326 192761 83_1_2 SeqId_13986_6 'LANC1 chr2:211346051_C_T$SeqId_13986_6 1 chr2:211346051_C_T rs3856349 cis 2 211346051 T C 0.4872 -0.1212 0.0126 4.98e-22 'LanC-like protein 1 ENSG00000115365 'LANCL1 intron_variant ENSG00000115365 ENSG00000115365 'LANCL1 3 novel specific_protein LANCL1 chr2 210431249 210477652 -1 10314 protein_coding 2:210481327 3675 84_1_1 SeqId_3434_34 'FN1.3 chr2:216299629_C_G$SeqId_3434_34 1 chr2:216299629_C_G rs1250247 cis 2 216299629 C G 0.2683 -0.1074 0.0151 1.05e-12 'Fibronectin Fragment 3 ENSG00000115414 'FN1 intron_variant 0.931786 rs1250259 ENSG00000115414 'FN1 missense_variant ENSG00000115414 ENSG00000115414 'FN1 7 known unspecific_effect FN1 chr2 215360440 215436073 -1 2335 protein_coding 2:215434906 1167 84_1_2 SeqId_17776_15 'PECR chr2:216905927_A_G$SeqId_17776_15 1 chr2:216905927_A_G rs7600044 cis 2 216905927 A G 0.103 -0.5742 0.0205 1.04e-172 'Peroxisomal trans-2-enoyl-CoA reductase ENSG00000115425 'PECR intron_variant 0.977872 rs9288513 ENSG00000115425 'PECR missense_variant ENSG00000115425 ENSG00000115425 'PECR 3 novel specific_protein PECR chr2 215996329 216082955 -1 55825 protein_coding 2:216041204 41751 85_1_4 SeqId_19606_28 'ihh chr2:219986253_C_T$SeqId_19606_28 1 chr2:219986253_C_T rs7561119 cis 2 219986253 T C 0.8979 0.1733 0.0214 6.13e-16 'Indian hedgehog protein ENSG00000163501 'IHH intron_variant 0.859349 rs56411706 ENSG00000181378 'CCDC108 missense_variant ENSG00000163501 ENSG00000163501|ENSG00000181378 'CFAP65|IHH 3 novel unspecific_effect IHH chr2 219054424 219060921 -1 3549 protein_coding 2:219121531 60610 85_1_6 SeqId_11351_233 'NHEJ1 chr2:220026369_G_T$SeqId_11351_233 1 chr2:220026369_G_T rs6713887 cis 2 220026369 T G 0.6357 -0.1817 0.0135 4.0e-41 'Non-homologous end-joining factor 1 ENSG00000187736 'NHEJ1 upstream_gene_variant ENSG00000187736 ENSG00000187736 'NHEJ1 3 novel specific_protein NHEJ1 chr2 219069357 219160865 -1 79840 protein_coding 2:219161647 782 86_1_2 SeqId_16288_17 'EPHA4 chr2:222387948_A_C$SeqId_16288_17 1 chr2:222387948_A_C rs13420556 cis 2 222387948 A C 0.483 -0.131 0.0131 1.75e-23 'Ephrin type-A receptor 4 ENSG00000116106 'EPHA4 intron_variant ENSG00000116106 ENSG00000116106 'EPHA4 3 novel specific_protein EPHA4 chr2 221418027 221574202 -1 2043 protein_coding 2:221523228 50974 87_1_1 SeqId_13485_20 'TM87B chr2:224880498_C_T$SeqId_13485_20 1 chr2:224880498_C_T rs68066031 trans 2 224880498 T C 0.7598 0.2132 0.0166 5.76e-38 'Transmembrane protein 87B ENSG00000153214 'TMEM87B intron_variant ENSG00000135919 ENSG00000135919 'SERPINE2 6 known unspecific_effect TMEM87B chr2 112055269 112119318 1 84910 protein_coding 2:224015781 111960512 87_1_1 SeqId_19154_41 'Protease nexin I chr2:224874874_A_G$SeqId_19154_41 1 chr2:224874874_A_G rs13412535 cis 2 224874874 A G 0.2366 -0.8898 0.0134 3.98e-960 'Glia-derived nexin ENSG00000135919 'SERPINE2 intron_variant ENSG00000135919 ENSG00000135919 'SERPINE2 6 known unspecific_effect SERPINE2 chr2 223975045 224039318 -1 5270 protein_coding 2:224010157 29161 87_1_1 SeqId_8258_22 'UXS1 chr2:224880498_C_T$SeqId_8258_22 1 chr2:224880498_C_T rs68066031 trans 2 224880498 T C 0.7597 0.1659 0.0161 4.97e-25 'UDP-glucuronic acid decarboxylase 1 ENSG00000115652 'UXS1 intron_variant ENSG00000135919 ENSG00000135919 'SERPINE2 6 known unspecific_effect UXS1 chr2 106093308 106194301 -1 80146 protein_coding 2:224015781 117821480 88_1_1 SeqId_11681_8 'NUPL chr2:228441159_D_I$SeqId_11681_8 1 chr2:228441159_D_I rs56147940 cis 2 228441159 D I 0.2946 0.1823 0.0141 3.76e-38 'Arf-GAP domain and FG repeat-containing protein 1 ENSG00000173744 'AGFG1 regulatory_region_variant ENSG00000173744 ENSG00000173744 'AGFG1 3 novel specific_protein AGFG1 chr2 227472152 227561217 1 3267 protein_coding 2:227576444 104292 89_1_1 SeqId_9769_48 'DNER chr2:230593969_A_T$SeqId_9769_48 1 chr2:230593969_A_T rs35709702 cis 2 230593969 A T 0.3368 -0.1783 0.0141 1.16e-36 'Delta and Notch-like epidermal growth factor-related receptor ENSG00000187957 'DNER intergenic_variant ENSG00000187957 ENSG00000187957 'DNER 3 novel specific_protein -0.33446 0.065903 5.54498020369743e-07 yes DNER Olink INFLAMMATION(v.3012) DNER chr2 229357629 229714555 -1 92737 protein_coding 2:229729253 14698 9_1_1 SeqId_16614_27 'RSPO1 chr1:38079517_G_T$SeqId_16614_27 1 chr1:38079517_G_T rs36043533 cis 1 38079517 T G 0.9436 -0.4028 0.027 2.99e-50 'R-spondin-1 ENSG00000169218 'RSPO1 missense_variant ENSG00000169218 ENSG00000169218 'RSPO1 3 novel specific_protein -0.57866 0.11115 2.8661571574642e-07 yes RSPO1 Olink NEUROLOGY(v.8011) RSPO1 chr1 37611350 37634892 -1 284654 protein_coding 1:37613845 21047 9_1_2 SeqId_5076_53 'EPHAA chr1:38197401_G_T$SeqId_5076_53 1 chr1:38197401_G_T rs12074120 cis 1 38197401 T G 0.6997 -0.1371 0.015 5.83e-20 'Ephrin type-A receptor 10 ENSG00000183317 'EPHA10 intron_variant 0.236367 rs6671088 ENSG00000183317 'EPHA10 missense_variant ENSG00000183317 ENSG00000183317 'EPHA10 3 novel specific_protein EPHA10 chr1 37713880 37765133 -1 284656 protein_coding 1:37731729 33404 9_1_3 SeqId_12641_3 'I5P2 chr1:38364229_C_T$SeqId_12641_3 1 chr1:38364229_C_T rs61776676 cis 1 38364229 T C 0.14 -0.4054 0.0177 1.45e-115 'Type II inositol 1,4,5-trisphosphate 5-phosphatase ENSG00000204084 'INPP5B intron_variant 0.984245 rs41311191 ENSG00000204084 'INPP5B missense_variant ENSG00000204084 ENSG00000204084 'INPP5B 3 known specific_protein INPP5B chr1 37860697 37947057 -1 3633 protein_coding 1:37898557 48500 9_3_1 SeqId_5238_26 'PPIE chr1:40203928_G_T$SeqId_5238_26 1 chr1:40203928_G_T rs514868 cis 1 40203928 T G 0.5447 -0.4072 0.0123 5.4e-240 'Peptidyl-prolyl cis-trans isomerase E ENSG00000084072 'PPIE upstream_gene_variant ENSG00000084072 ENSG00000084072 'PPIE 3 known specific_protein PPIE chr1 39692182 39763914 1 10450 protein_coding 1:39738256 46074 9_3_2 SeqId_9244_27 'PPT1 chr1:40564553_C_T$SeqId_9244_27 1 chr1:40564553_C_T rs6600314 cis 1 40564553 T C 0.2884 0.1877 0.0135 5.34e-44 'Palmitoyl-protein thioesterase 1 ENSG00000131238 'PPT1 upstream_gene_variant ENSG00000131238 ENSG00000131238 'PPT1 3 known specific_protein PPT1 chr1 40072710 40097260 -1 5538 protein_coding 1:40098881 1621 90_1_1 SeqId_6715_63 'PPBN chr2:233301535_C_T$SeqId_6715_63 1 chr2:233301535_C_T rs11886043 cis 2 233301535 T C 0.7569 -0.2497 0.016 7.12e-55 'Alkaline phosphatase, placental-like ENSG00000163286 'ALPPL2 intergenic_variant 0.184226 rs17416141 ENSG00000163286 'ALPPL2 missense_variant ENSG00000163286 ENSG00000163283|ENSG00000163286 'ALPG|ALPP 3 known specific_pathway ALPG chr2 232406844 232410714 1 251 protein_coding 2:232436825 29981 90_1_1 SeqId_7813_6 'Alkaline phosphatase, placental chr2:233286654_C_T$SeqId_7813_6 1 chr2:233286654_C_T rs12478529 cis 2 233286654 T C 0.2416 0.3954 0.0157 1.96e-139 'Alkaline phosphatase, placental type ENSG00000163283 'ALPP upstream_gene_variant 0.538371 rs13026692 ENSG00000163283 'ALPP missense_variant ENSG00000163283 ENSG00000163283|ENSG00000163286 'ALPG|ALPP 3 known specific_pathway ALPP chr2 232378724 232382889 1 250 protein_coding 2:232421944 43220 90_2_1 SeqId_17702_53 'UGT 1A1 chr2:234664586_D_I$SeqId_17702_53 1 chr2:234664586_D_I rs35754645 cis 2 234664586 D I 0.3215 -0.2842 0.014 8.13e-92 'UDP-glucuronosyltransferase 1-1 ENSG00000242366 'UGT1A1 intron_variant 0.788436 rs2070959 ENSG00000167165 'UGT1A6 missense_variant ENSG00000242366 ENSG00000167165|ENSG00000242366 'UGT1A6|UGT1A8 3 known unspecific_effect UGT1A8 chr2 233617633 233773300 1 54576 protein_coding 2:233755941 138308 90_2_1 SeqId_7891_45 'UGT 1A6 chr2:234672639_G_T$SeqId_7891_45 1 chr2:234672639_G_T rs6742078 cis 2 234672639 T G 0.3234 -0.237 0.0135 6.22e-69 'UDP-glucuronosyltransferase 1-6 ENSG00000167165 'UGT1A6 intron_variant 0.789338 rs2070959 ENSG00000167165 'UGT1A6 missense_variant ENSG00000167165 ENSG00000167165|ENSG00000242366 'UGT1A6|UGT1A8 3 known unspecific_effect UGT1A6 chr2 233691607 233773300 1 54578 protein_coding 2:233763993 72386 91_1_1 SeqId_11196_31 'Collagen alpha-3(VI) chr2:238220307_A_G$SeqId_11196_31 1 chr2:238220307_A_G rs2029998 cis 2 238220307 A G 0.6715 0.1265 0.0142 3.85e-19 'Collagen alpha-3(VI) chain ENSG00000163359 'COL6A3 intergenic_variant 0.224071 rs1131296 ENSG00000163359 'COL6A3 missense_variant ENSG00000163359 ENSG00000163359 'COL6A3 3 novel specific_pathway COL6A3 chr2 237324003 237414328 -1 1293 protein_coding 2:237311664 102664 91_1_2 SeqId_10511_10 'Collagen alpha-3(VI) chr2:238277795_A_G$SeqId_10511_10 1 chr2:238277795_A_G rs2646260 cis 2 238277795 A G 0.75 0.1401 0.0158 5.88e-19 'Collagen alpha-3(VI) chain ENSG00000163359 'COL6A3 synonymous_variant ENSG00000163359 ENSG00000163359 'COL6A3 3 known specific_protein COL6A3 chr2 237324003 237414328 -1 1293 protein_coding 2:237369152 45176 91_2_1 SeqId_18213_30 'UBE2F chr2:238869884_C_T$SeqId_18213_30 1 chr2:238869884_C_T rs6723077 cis 2 238869884 T C 0.4579 0.1071 0.0128 6.26e-17 'NEDD8-conjugating enzyme UBE2F ENSG00000184182 'UBE2F intergenic_variant ENSG00000184182 ENSG00000184182 'UBE2F 3 novel specific_protein 0.16566 0.061141 0.00697910930199934 yes UBE2F Olink NEURO EXPLORATORY(v.3901) UBE2F chr2 237966827 238042782 1 140739 protein_coding 2:237961242 5585 92_1_2 SeqId_9940_35 'DUS28 chr2:241386175_C_G$SeqId_9940_35 1 chr2:241386175_C_G rs148245427 cis 2 241386175 C G 0.9842 0.9585 0.0532 1.61e-72 'Dual specificity phosphatase 28 ENSG00000188542 'DUSP28 intron_variant 0.191647 rs532600172 ENSG00000188542 'DUSP28 inframe_insertion ENSG00000188542 ENSG00000188542 'DUSP28 3 novel specific_protein DUSP28 chr2 240560054 240565256 1 285193 protein_coding 2:240446758 113296 92_1_3 SeqId_8697_38 'Glypican 1 chr2:241405479_C_T$SeqId_8697_38 1 chr2:241405479_C_T rs1126920 cis 2 241405479 T C 0.1129 0.5818 0.0202 1.23e-181 'Glypican-1 ENSG00000063660 'GPC1 synonymous_variant 0.245664 rs34976040 ENSG00000063660 'GPC1 missense_variant ENSG00000063660 ENSG00000063660 'GPC1 3 known suggestive_specific_pathway 0.46877 0.090041 2.85890681551196e-07 yes GPC1 Olink ONCOLOGY II(v.7002) GPC1 chr2 240435663 240468076 1 2817 protein_coding 2:240466062 30399 92_3_2 SeqId_19504_22 'KTHY chr2:242630880_A_C$SeqId_19504_22 1 chr2:242630880_A_C rs148221699 cis 2 242630880 A C 0.0344 -0.2567 0.0365 2.14e-12 'Thymidylate kinase ENSG00000168393 'DTYMK upstream_gene_variant ENSG00000168393 ENSG00000168393 'DTYMK 3 novel specific_protein DTYMK chr2 241675747 241686944 -1 1841 protein_coding 2:241691465 4521 93_1_1 SeqId_8958_51 'CHL1 chr3:93078_A_G$SeqId_8958_51 1 chr3:93078_A_G rs13077895 cis 3 93078 A G 0.6398 0.312 0.0139 2.26e-111 'Neural cell adhesion molecule L1-like protein ENSG00000134121 'CHL1 downstream_gene_variant ENSG00000134121 ENSG00000134121 'CHL1 3 known specific_protein 0.2906 0.065302 1.06659612123026e-05 yes CHL1 Olink CARDIOMETABOLIC(v.3602) CHL1 chr3 196763 409417 1 10752 protein_coding 3:51395 145368 93_1_2 SeqId_3298_52 'Contactin-4 chr3:533279_A_T$SeqId_3298_52 1 chr3:533279_A_T rs12491457 trans 3 533279 A T 0.6229 0.106 0.0138 1.53e-14 'Contactin-4 ENSG00000144619 'CNTN4 intergenic_variant ENSG00000134115 ENSG00000134115 'CNTN6 1 novel specific_protein CNTN4 chr3 2098813 3057959 1 152330 protein_coding 3:491596 1607217 94_1_1 SeqId_3298_52 'Contactin-4 chr3:3098041_C_G$SeqId_3298_52 1 chr3:3098041_C_G rs163352 cis 3 3098041 C G 0.8166 -0.3469 0.0174 5.95e-88 'Contactin-4 ENSG00000144619 'CNTN4 3_prime_UTR_variant ENSG00000144619 ENSG00000144619 'CNTN4 3 known specific_protein -0.32132 0.083847 0.000143747400587436 yes CNTN4 Olink DEVELOPMENT(v.3511) CNTN4 chr3 2098813 3057959 1 152330 protein_coding 3:3056357 957544 94_1_2 SeqId_13686_2 'IL-5 Ra chr3:3150964_A_G$SeqId_13686_2 1 chr3:3150964_A_G rs77400868 cis 3 3150964 A G 0.8583 -0.4919 0.019 1.0e-147 'Interleukin-5 receptor subunit alpha ENSG00000091181 'IL5RA intron_variant 0.159756 rs2290610 ENSG00000091181 'IL5RA missense_variant ENSG00000091181 ENSG00000091181 'IL5RA 3 known specific_protein -0.52111 0.088941 8.65565623862658e-09 yes IL-5R-alpha Olink NEUROLOGY(v.8011) IL5RA chr3 3066324 3126613 -1 3568 protein_coding 3:3109280 17333 95_1_1 SeqId_7628_40 'CREL1 chr3:9981913_C_G$SeqId_7628_40 1 chr3:9981913_C_G rs7650290 cis 3 9981913 C G 0.7548 1.0781 0.0118 2.06e-1815 'Cysteine-rich with EGF-like domain protein 1 ENSG00000163703 'CRELD1 intron_variant ENSG00000163703 ENSG00000163703 'CRELD1 3 known specific_protein CRELD1 chr3 9933793 9945413 1 78987 protein_coding 3:9940229 6436 95_2_2 SeqId_6462_12 'TIMP-4 chr3:12134740_A_G$SeqId_6462_12 1 chr3:12134740_A_G rs184262 cis 3 12134740 A G 0.1744 -0.4544 0.0159 3.13e-179 'Metalloproteinase inhibitor 4 ENSG00000157150 'TIMP4 intron_variant ENSG00000157150 ENSG00000157150 'TIMP4 3 known unspecific_effect -0.34215 0.076589 9.87643022777107e-06 yes TIMP4 Olink CARDIOVASCULAR III(v.6112) TIMP4 chr3 12153068 12158912 -1 7079 protein_coding 3:12093240 65672 96_1_1 SeqId_15644_1 'Biotinidase chr3:15686693_C_G$SeqId_15644_1 1 chr3:15686693_C_G rs13078881 cis 3 15686693 C G 0.0403 -1.6783 0.03 3.61e-682 'Biotinidase ENSG00000169814 'BTD missense_variant ENSG00000169814 ENSG00000169814 'BTD 3 known specific_protein BTD chr3 15601341 15722311 1 686 protein_coding 3:15645186 43845 98_1_1 SeqId_18174_79 'PDC6I chr3:33841065_A_G$SeqId_18174_79 1 chr3:33841065_A_G rs9876986 cis 3 33841065 A G 0.7349 0.1411 0.0138 1.5e-24 'Programmed cell death 6-interacting protein ENSG00000170248 'PDCD6IP intron_variant 0.987958 rs3792594 ENSG00000170248 'PDCD6IP missense_variant ENSG00000170248 ENSG00000170248 'PDCD6IP 3 novel suggestive_specific_pathway PDCD6IP chr3 33798571 33869707 1 10015 protein_coding 3:33799573 1002 99_1_2 SeqId_17782_23 'THIK chr3:38274503_A_G$SeqId_17782_23 1 chr3:38274503_A_G rs114563337 cis 3 38274503 A G 0.0406 -0.7835 0.033 1.41e-124 '3-ketoacyl-CoA thiolase, peroxisomal ENSG00000060971 'ACAA1 intron_variant 0.929554 rs2229528 ENSG00000060971 'ACAA1 missense_variant ENSG00000060971 ENSG00000060971 'ACAA1 3 novel specific_protein ACAA1 chr3 38103129 38137242 -1 30 protein_coding 3:38233012 95770