#NEXUS [ Title ] begin taxa; dimensions ntax=28; taxlabels Bactrocera_latifrons Bos_taurus Caenorhabditis_elegans Cebus_capucinus_imitator Chrysemys_picta_bellii Ciona_intestinalis Danio_rerio Delphinapterus_leucas Drosophila_melanogaster Echinococcus_multilocularis Equus_caballus Exaiptasia_pallida Felis_silvestris_catus Gallus_gallus Gorilla_gorilla_gorilla Homo_sapiens Hydra_vulgaris Mus_musculus Nomascus_leucogenys Pan_troglodytes Panthera_pardus Pongo_abelii Rattus_norvegicus Sus_scrofa Taeniopygia_guttata Takifugu_rubripes Trichoplax_adhaerens Xenopus_tropicalis ; end; begin characters; dimensions nchar=4957; format missing=? gap=- matchchar=. datatype=protein; matrix Bactrocera_latifrons -----MTMLHA------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------INSAA ATALASTVAA------------------------VGVPRSM------------------- ------------------------------------------ATTSD------------- ------------------------------------------------------------ ----------------------G------------------------------------- ------STNALKGA---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----AGIGLSTP------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------TMT------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------TSTVRHN EPNVIGAQA--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -QATYANRGQA------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------LI-----------------DSG---------HASGVVSVAAVAAS- ------------------------------------------------------------ ------------G----------------------------------------------- ------------------------------------------------------------ ----------------------------------DDHNQPHLS----------------- ------------------------------------------------------------ ---------------------------------------------ATEY----------- ----------------------------------YRL----------MGELFASGLNLQ- ------AAKSERAGDCVK------------------------------------------ ------------------------------------------------------------ -------------------------------------------HIKLFEPLVIYCLMLFL KSNARV--QAPILELLSQLLELNVTYSVLDSKNVIFDQILNNLDLIENGIV--------- -RNGPVIV?PMIKFLIQLTHKS---------DRKLITIPKIISITNNLLANN-AVLDCAV LALKSLSYEIFFMPPVGGSAALNTLADYRAPFQSPVTRSPVQQRRH--AAEESAAAAAAA EALLANS-----------RELDTQKEVVLGMLE-KFVDATELQHVVALLLLRERCAQQMD -----------GGAFARRMEGGDAATVERQKSSCILESTRLQDPGVVYALICRAMCDGRL GVHNWRDFYTLESCFKNYSKYVLADSKNFLALLQ-LFLTEGVECFSALAHATIILANVI? KTEE----IYLVNHIKLYLKNHPAVEEQERQRAHQQRMQQQQQQQQRATLWLLDGPSTST AAARAAA-NALSATAADAGAGA--------ASTSAPGVGISEINYFAKVLCEK?EHCFDA VA------GTDNSP?SGDAAYSRLVCRFVAALHEVCCRSRHKDALQSVFRLVLAE---SA LLDKYCNFLTMD?WRQ??DAD?HVGANAA??EDDAVYECCRTVSLGQALQLQLEVLKLLS AMKLLDPV-VMLQLLKQQKQNALQQLQQQQHAQQMATNKERLKWCDNMQRTLLSEICQQN PYA--RDWSTQQVRQLLDLGGATFLNFLITEHFELISDLCE-------------VAAVLK AAQAT-----------------REAADQLDVLWLNALL-QHASALNKHSI---RALPPLL LR---LCNVTRTSVA---GCNLQMALLSLQLLQRLHARHNNARALQVRLERLARRLVFSC SAAPLQRQQLLQQLSELAGDRLTAFGSNNTSTTFWQQLFLDTEDCEPAAQPLASLAKEQH QLQQRIIDEKWLLSQLIKF-----SAQSDYGA-------QQLSRILLEIQSEQKLYKIFN SS--EFAVARVLRHVIASSMQAMLAAFRNNCIQHNPHIHYMQP-------------NPL- ----VRVTLAVLMTRISEEIAAPGNRSANLHIPIMTTLGGGATTEAVPISGVHTQAHVAS DGGFYLCDSVATLLEHVKKVEDTALFYIESRFIDKFVCEQLLRHEHVATLL--------G FLNWCCLQAQQLLQRQAEQKCQQQQFTLALLQCIAALLQ-ERFIWTELNHMEKPSVATTT TATADGSAATAASNANTAGSLLSPPQRNLLLCRVLDVLVLAA?QSLQHTIFYKHYKQQAL LVDGSGSVDGQHASIDSEQQHIFNALSAAAASTALEAALQTKDNEAEVNDVAVGRLLQAY APQAIFLAKLIELRAAETTSGAAHLSAAYLTGGAGNGVCSLGSAGGALSVGGSSGMGMSS GATGAVGVGATAGVRAEFDNGSNAAGIQIPMHLLSTIGVAVLRTHQFYAYAVTPFEIIQQ QQRELRIEQLSPAKRAGQPSQTATSAAATAAASSGKLPTIPVESLSDVDVLRKFVKRLSI FGFTTRQQFEEYFMTFL---------------LLINKVYD---ENMVDEQEQFQIRSTCL EAILELLITYKTFPIVGNK-LSHFHHTTRWT-RINC-DSISLKKLHKVQLLVAEANIFYH P---NLERQLRADCEARANYSSYACRL--------------------------------- ----RDSVIGTHQFRVNQYD----------------LNFMWQQMEAYAQYTAHNSSAPNA ELASESA-------------------IGASTAQRAKRGTGGGGGARDSEDVATKNYRYFT AQSGV-------------DFKSSTQLIFDVLMQII---------------EHNHILVLPN LVK----FAEICESRDQIKWIKDKALKLQETIPMDDT----ISHQHLIYLLCKTQAMLIP TI-------GELQQLCQ-----------------------LIGN-YLKSSH--------- ---IFIRNATLAGLLCLLECCSKTNTTIGRLSDELALLRDLIVGYI--NRHGIIDVSAM- ------------------------------------------------------------ -------------------QCSDTHTKLVWTLNYCLIEWTSKFVPQ---------CHLLS NTVIAAGNFLRKTNNED--------VYL------------------CVLHGLERMVVISN TGNNGMSTS?GASAVSSAVGS?AVG----IVTPLLRNKIEKLALELVKLEN-ER?SIPAL QLLLTCMYV-------------------------------------GSAKQLE--NTELS NGIV-QDEPEIIA---QQTDKVD-----ILLHCIK--------------SSTRDAAWIYG QVLCQIIRDL---------VPPNE-------ILTKVIKEFLAI-NQPHCDVMAMIVYQVF RCAIDSTFLQVL-QDWLICSLPTFLA-LPEQKAVWCLSVIFLSASINLHLIKLFPVLLST GAAAAATAASTT?GGGDVGGGAAAGASGGTVGGVGNLDAS?AAGLTLGAGDGADAGAVAG GVGEFHKLG-QHEIALFVTAAVDFHAKLSAEQ--------RPRFRDAFEKFAQ---RQTV YAQLL?SL----------------------------- Bos_taurus -----MATLEK------------------------------------------------- ---------------------------------LMKAFESLKSF---------QQQQQQQ QQQQQQ----PPPPPQPPQPPQPPPQAQPP-------PQPPPPPPPLGPAAAEEPLHRPK KELSATKKDRVHH-CLTICENIVAQSLRNSPE-FQKLLGIAMELFLLCSDDAESDVRMVA DECLNKVIKA-----LMDSNLPRLQLELYKEIKKNGAPRSLRAALWRFAELAHLVRPQKC -RPYLVNLLPCLTRTSKRPEESV-QETLAAAIPKIMASFGNFANDNE-IKVLLKAFIANL KSSSPTVRRTAAGSVVSICQHSRRT-QYFYSWLLSVLLGLLVPVEGE-HPTLLILGVLLA LRYLVPLLQQQV-KDTSLKGSFG----------VTRKEMEVSP-STEQLVQVYELTLHYT QHQ---DHNVVTGALELLQQLLRTPPP-----------ELLRALTTAGGVRQ-------- -------------LAASKDEPGGRSRSGSIVELIAGGGSSCSPVLSRKQKGKVLFGEAAP LEDDSEPRSEGSSPAFSASVKGEVGGELAA-SSG----ISTPGS-ASSAADSVGHDIITE QPR-SQHTLQT-DAVDLAACD-----------LTSAATDGDEEDILSHSSSQMSAVPSDP AMDLNDG-TQ--------------ASSPISDSSQTTTEGPDSAVTPSDSSEI-------- -------------------------------------------------------VLDGT DSQYPGMQVGQTQDED-ED-ATAVL----------------------------------- --PDEDAEAFRNSSIALQQAHLLKSM-------------------GHCRQSSDSSVDKFV SREEAAEPGDPENKPCRVKGDI----GQSTDE---DSAPLVHCV---------------- -------RLLSASF-LLTGEKNALVPDRDVRVSVKALALSCIGA-AVALHPESFFSKLYR AP---------------------------------------------------------- ------------------------------------------------------------ -----------------------------LDTV-EYPEEQ-----YVSDV---LNYVDHG DPQVRGATAILCGTLICSV----------------------------------------- --------------------------------------------LGRCRFHVAGWMGAVR ARTGNT-F---SLADCIPLLQKTLKDE-SSVTCKLACAAVRLCVMSLC------------ -SSSYSAWGLQ--------------------------------------------LITNL LALRSSSYWLVRTELLETVAEIDFRLVSFLEAK----AESLHRGAHHYTG---------- -----------LLKLQERVLSNVVIHLLGDEDPRVRHVAAASLMRLVPK----------- --------------LF--------------YKCDQG---------QADPVVAVARDQSSV Y-----LTLLMHETQPPSHFSVSAV-TRIYRGYNLLPSITDV-TLEN-NLSRVIAAVSHE LITSTTRALTFGCCEALCLLSTAFPVCIWSLGWHC-G----------------------- VPPLSAS----------DESRKSCTV------GMVSMILTL--LSSA-------WFPLDL SAHQDA----LILAGNLLAASAPRSLR--SSWASEDEASTAAT-------KQEEAWPALG DRTLVPMVEQLFSHLLKVINICAHVLDDV-APGPAV--------------KAALPSLTNP P----SLSPIR-------RKGKEKEPGEQASVPVSPK----K---GSEASPASRPPETSG PVAT--NKSSSLGSFCHLPSYLKLHDVLKATHANYKVTLDLQSSGEKFGGFLRSALDVLS QILE--LATLQDIGKCVEEILGYLKSCFSREPMMATVCVQQLLKTLFGTNLASQLDGLSS H--AS---KSQGRAQRLGSSS--ARP-------GLYHYCFMAPYTLFTQALADASLRNAA -QAEQDQDTAGWFDVLQKVSTQLKTNLTSVTKN-RADKNAIHNHIRLFEPLVIKALKQYT TTTSVQL-QKQVLDLLAQLVQLRVNYCLLDSDQVFIGFVLKQFEYIEVGQF--------- -RESEAIIPNIFFFLVLLSYER--Y-----HSKQIIGIPKIIQLCDGIMASGRKAVTHAI PALQPIVHDLFVL-------------------------------RG--TNKADAG----- ------------------KELETQKEVVVSMLL-RLIQ---YHQVLEMFTLVLRQCHKES -----------EDRWKR---------LSRQVADVILP----------------MLAKQQM HIDSHEALGVLNTLFEILAPSSL---RPVDMLLRSMF----------------------V TPDT----LAAVSTVQLWVSGILAILRVLISQSTEDIVLSRIQ----------ELSFSPY LVSCPTI-SRLRDGDST-SALE--------EHTEGRQMKNLPEETFARFLLQLVGVLLED IV--TKQLRVEVSEQQQT-FYCQELGTLLMCLIHIFKSGTFRRITAAASRLLR-D---GA DGG-FYGLESLNAW---------VRSMVPTHPALVLLWC-----------------QILL LVSHTDYR-WWAEVQQTPKRRSLSSTKSLSPETSGEDEDPDVASKLGM---CNREIVRRG ALILFCDYVCQNLHDS------EHLTWLIVNHIQDLINLSH------EPPVQDFISAIHR NSAAS----GLFIQAIQ-----SRCENLSTPTMLKRTL-QCLEGIHLSQS---GAVLMLY VD-KLLCTPFRVLAR-------MVDTLACRRVEMLLAANLQSSTAQLPAEELIRIQEHLQ SSGLAQRH---QRLYSLLDRLRLATAPGSHGPT-------------PPVTSHPLDGDGPL ALEAVNPDKDWYVQLVKAQ----CWTRSDSAL-------LEGAELVSRIPAGD-LGAFMM HS--EFNLSLLAPCL-GLGMREISGGQE----------------------------SPL- ----FEAARTATLDRV----TVVVQQLPAVH---------EAFQPFLPTQPSA------- ------------YWSKLDDLFGDAALYRTLTTLAQALAQYLLVFSKLPSHLHLPPEKERD TVKFMVMTVEALSWHLIHSRVPLSLDLQAGLDCCCLALQ-LPGLW--------------- -------------------SLLAAPDMVTHACSLIHCV---------------RFILEAI VVQPG------------------DQLLSPERRTSTPKAAR--EDSVDSDTQNP-QYITAA ---CGMVAEMVE-----------CLPSVLALGHKRN------------------------ ---------------------SRTPAFLTP--VLRNIVISLARLPLVNSYMRVPPLVW-- --------KLGWSPKPGGDFGTV-------------FPEIPVEFLQEKEVFREFIYRINT LGWTSRTQFEETWATLLGVLVTQP--------LMMEQEES----PPEEDVERTQIHVLAV QAITSLVLSAMTVPVAGNPAVSCLEQQPRNK-PLKALDTRFGRKLSIIRGIVEQEIQAMV S--------RRENAATHHLYQAWDPVP-SLAPAT-TGALISH---------DKLLLQ--- --LNPERELGDMSYKLGQVS----------------IHSVWLG----------NSITPLR EEEWDEE---------------------------EEETEAPAPSSPPTSPINSRKHR--- --AGV-------------DIHSCSQFLLELYSRWI--------LPSSSA-RRTPVTLISE VVRSLLVVSDLFTERSQFETMYLTLTELRKVHPSEDE----ILLQYLVPATCKAAAVLGM DK-------AVAEPVSR-----------------------LLES-ALRSSH--------- ---LPSTMGALHGVLYVLECDLLDDTAKQ--------LVPVVTDYLLSNLQGRAHCVSV- ------------------------------------------------------------ -------------------HSQ-QHVLVMCATAFYLIENYPLDVG----------PDFSA SVIQMCGVMLSGSE-EATPSV----VYH------------------CVLRGLERLLLSE- -----------------------------QLSRLDAESLVKLSVDRVNVHS-PHRAMAAL GLMLTCMYT-------------------------------------GKEKVSP-GRASEP STAA-PDSESVI----VAMERVS-----VLFDRIR--------------KGFPCEARVVA RVLPQFLDDF---------FPPQD-------VMNKVIGEFLSS-QQPYPQFMATVVYQVF QTLHGAGQSPMV-RDWVMLSLSNFTQRSPVAMAMWSLSCFFVSASTSPWVSAILPHVVS- ------------------------------------------------------------ ---RMGKLE-QVDVNLFCLVATDFYRHQIEEE------LDRRAFQSVFEVVAV---PGNP YHRLLACLRSVQKAAAC-------------------- Caenorhabditis_elegans ---MTSTVLAQ------------------------------------------------- ---------------------------------ITDELSTNVSL---------------- -----------------------------------------------------------D RELNLLKSA-----HKIIDKNLKVNVLTDRNDTYYRYVHRLMNLTFISLEKNNADIRLAA EAYYEHILKAYECYGFPETSLKILAMSIEKMNGARQATKMIKYLVYYLDILPKQHAPEKS GRTFYQEVVKNFILKSLNINQTICHQALEKWCGKLISSV--VWQNAD-LKEITEKALQKL WSTRGHASRTMAAVIGAVIEESKEMFRVMFNTHLDKVIETFV------SNQVVPVGTISM IRKSIHIYISGI--------------------------------SVDSLKGLIEMLLLMI RDS---SNEVAYDAFATLEELMKVEIP--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------QMDGFVPGN FLKLKYG----------------------------------------------------- ------------------------------------------------------ESISKP EEHVEDVEFVDP-----------LV----------------------------------- --NADLYEQLQETKPPPKIDLLLEDF-------------------EKMSLNANRSVTNYV -------------------------------------------V---------------- -------AFLGKTF-LLTGSEKLLKTDRQSKDSMKILALRVLNVICARTSIENYEVRF-- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------GDKNQ------LMIDV---ICYSTST DDQLSQQAI----KFMFLV----------------------------------------- --------------------------------------------LQRG------------ ------------------------------------------------------------ -TEIYNGLDLF------------------------------------------------- KSVKKFRYLLDSVSVEHVLHLKNQQLLEYLEIM----AFRSLYSTHY------------- ------------------------------------------------------------ --------------DF--------------SLAEIT---------SACAFMSVMRDWIQV N-----------NIKENKHLEVMER---------FQNCLKNC-VIDCWDSPRFINTISTM LNYHSSETACEDQYPPSLPLRVDFPHVHRTS----------------------------- -----------------SKANRFKQI-----------------VYDD-------W----- -------------RTTLLCEARMPTYVKMTAILRESVNSPEFS---------HEKVPKLS RMHWNSDTLPAVLQVMTVSLSDSHSKEDC-YHGFHV--------------GMSVLNWVYR N-----VFIVR-------------GAAETKEFPFLQH-------------SRTEMDDTLG NRTE-----------------------FRATLDAYYKTVQS-SADEKLEQLLTPTINLML AAM---AHDFKTSTENILEIIVYITVLFTLSPISALKLLNVLLRCLLDPKLIES------ --------LTSGRVFYFASSN---------------TNNFETNDEFLIEAL--------- -KCDGDKYFNRWGDDMEVEKIKMGAMKEEILEQ--------------LEPLITQSLKCFR YRGKNE--KKQVLQIMICLMNHKLKLSDADPTECLMKFAVSTFA---------------- -RPEECAHSELFDTLMHFLATATRFQKDESYQKPMIAATMLMKSIEKLSNPG------IV NAMKAVSFALFNG-------------------------------RY-------------- ----------------------------------EFTD-------IEEFLHTSHST---- --------------WKL-----------------------------------------CM QVAPTETLYTLSLLLEK---------NEFGMKNQKLF----------------------- -----------------W-----SVLREWTPHDSLKV----------------EVPFSAI ALPVSLITNYLTSDKVN--------------------------------IFEIINQWLDD PV-----PENTLKE-------CTIIVALYFTLNNGDRAIDWKRYFEHC------------ ----FSKFNNTKAT-----------HLLSKYADSSLLPN-----------------RV-- ------------------------------------EESD-----------LDEELTGND SV--------------------DIDNLLEKHHCGSIQDLCHSIICSGETSVLDFLNLIER EYPNDDSIWGFLLAEFR-----RLDDDLEHRLDITFRLQDLVDALSERFN---SNMFLKL LG--------------------------------------NTNLAGIHLNNLSI------ -----------PKIKLMFDQVSFDYTEDG------------------------------- ----------YVLRGIRNL--------------------LVSPRMLHFISEDE-LETAQM ----------------FLNLAEKVAG---------------------------------- ------------------------------------------------------------ -----------------------------IMTTDALIATYSQYRIDFQVKCDMDEAKVKE IKKFALSMFAFCQ----EAHLRHSKRFSKTLSAC---FR-HPILN--------------- -------------------SMFNIP-LVA-----MKCF---------------------- ------------------------------------------------------NWV--- ------------------------------------------------------------ -----------------------------P-------VVEILRKPTITC----------- ------------------------------------LP--PTGHVCDVMVLEDMKRRLSK VGLVTNAQFEVLFTTMQAVIAHTV--------IGPEKMHH----DEKDVLEREARSCNAL QLYIATILTSLKYPNGGDPSSGFVLKSPYIS-EL-FLQSTEFAHLCNLKSVWKCEPRTAF T-----------TPLERHDQKSW------------------------------------- ----THCDGKTNLYGICQTP----------------LFSLWQL----------CGMMPIE FRQHANY----------------------------HRIDHSASNYFLTSA---------- --TNI-------------DTISNVKQLMNIFEYWY-----------SQGIGELGDTLLHS ILHTILYLSDFFDDPDLHKAVLRTTSIIYRHQYDQNS----VLSSFVHAMFFKSIAVLGA DVHGTEFKPGEPESIALK----------------------LVSS-GLSNDI--------- ---KTVRIYTLAGVLYLVQSDSYESFISS---------IDILSAYLEKYLKKLANGSGR- ------------------------------------------------------------ -------------------VES-DESQFALALIIKLME-TPMRLK----------QDKKT ILKLLLASMRVRRE-----RF----IIE------------------LIAEGIEQLLCRS- -----------------------------NEFNNEVINFVLVGVDSGDATPFPADNEYYC RAVYRILMV-----------------------------------AATREKVAN------- ------DE--------VSMTRIYNALQIIGFDMLS--------------RG--ETAPAIS RTLPFFSICV---------NGVET-------TISKYIERFVINGNKKDRRFVSTLINQIV ETAATS-------KKWSV-ELKLYRERLKSKSV--------ANADDNQWL---------- ------------------------------------------------------------ -------------LNILCNKIVE------------------------------------- ------------------------------------- Cebus_capucinus_imitator -----MDNSTH------------------------------------------------- -----------------------------------TNFLLFFIF---------------- ----------------------------------------------------------RK KELSATKKDRVNH-CLTICENIVAQSVRNSPE-FQKLLGIAMELFLLCSDDAESDVRMVA DECLNKVIKA-----LMDSNLPRLQLELYKEIKKNGAPRSLRAALWRFAELAHLVRPQKC -RPYLVNLLPCLTRTSKRPEESV-QETLAAAVPKIMASFGNFANDNE-IKVLLKAFIANL KSSSPTIRRTAAGSAVSVCQHSRRT-QYFYSWLLNVLLGLLVPVEDE-HSTLLILGVLLT LRYLVPLLQQQV-KDTSLKGSFG----------VTRKEMEVSP-SAEQLVQVYELTLHHT QHQ---DHNVVTGALELLQQLFRTPPP-----------ELLQALTTMGGIGQ-------- -------------LTEAKDESGGRSRSGSIVELIAGGGSSCSPVLSRKQKGKVLLGEEEA LDDDSESRSDVSSSAFAASVKDEISGELTA-SSG----VSTPG--------SAGHDIITE QPR-SQHTLQA-DSVDLAGCD-----------LTSSATDGDEEDILSHSSSQVSAVPSDP AMDLNDG-TQ--------------ASSPISDSSQTTTEGPDSAVTPSDSSEI-------- -------------------------------------------------------VLDGA DSQYLGLQIGQPQDED-EE-ATGVL----------------------------------- --PDEASEAFRNSSMALQQAHLLKNM-------------------SHSRQPSDSSVDKFV SRDEAAESGDQENKPCRIKGDI----GQSTDD---DSAPLVHCV---------------- -------RLLSASF-LLTGGKNVLVPDRDVRVSVKALALSCVGA-AVALHPESFFSKLYK VP---------------------------------------------------------- ------------------------------------------------------------ -----------------------------LDTT-EYPEEQ-----YVSDI---LNYIDHG DPQVRGATAILCGTLICSI----------------------------------------- --------------------------------------------LSRSRFHVGDWMGTIR TLTGNT-F---SLADCIPLLRKTLKDE-SSVTCKLACTAVRHCVMSLC------------ -SSSYSELGLQ--------------------------------------------LIIDV LTLRNSSYWLVRTELLETLAEIDFRLVSFLEAK----AENLHRGAHHYTG---------- -----------LLKLQERVLNNVVIHLLGDEDPRVRHVAAASLIRLVPK----------- --------------LF--------------YKCDQG---------QADPVVAVARDQSSV Y-----LKLLMHETQPPSHFSVSTI-TRIYRGYNLLPSITDV-TMEN-NLSRVIAAVSHE LITSTTRALTFGCCEALCLLSTAFPVCIWSLGWHC-G----------------------- VPPLSAS----------DECRKSCTI------GMATMILTL--LSSA-------WFPLDL SAHQDA----LILAGNLLAASAPKSLR--SSWTSEEEANPAAT-------KQEEVWPALG DRALVPMVEQLFSHLLKVINICAHVLDDV-APGPAI--------------KAALPSLTNP P----SLSPIR-------RKGKEKEPAEQASVPLSPK----K---GSEASAASRQSDTSG PVTT--SKSSSLGSFYHLPSYLKLHDVLKATHANYKVTLDLQNSTEKFGGFLRSALDVLS QILE--LATLQDIGKCVEEILGYLKSCFSREPMMATVCVQQLLKTLFGTNLASQFDGLSS N--PS---KSQGRVQRLGSSS--VRP-------GLYHYCFMAPYTHFTQALADASLRNMV -QAEQEHDTSGWFDVLQKVSTQLKTNLTSVTKN-RADKNAIHNHIRLFEPLVIKALKQYT TTTSVQL-QKQVLDLLAQLVQLRVNYCLLDSDQVFIGFVLKQFEYIEVGQF--------- -RESEAIIPNIFFFLVLLSYER--Y-----HSKQIIGIPKIIQLCDGIMASGRKAVTHAI PALQPIVHDLFVL-------------------------------RG--TNKADAG----- ------------------KELETQKEVVVSMLL-RLIQ---YHQVLEMFILVLQQCHKEN -----------EDKWKR---------LSRQIADIILP----------------MLAKQQM HIDSHEALGVLNTLFEILAPSSL---RPVDMLLRSMF----------------------V TPNT----MASVSTVQLWISGILAILRVLISQSTEDIVLSRIQ----------ELSFSPY LISCPVI-NRLRDGDSN-STLE--------EHSEGKQIKNLPEETFSRFLLQLVGILLED IV--TKQLKVEMSEQQHT-FYCQELGTLL-------KSGMFRRITAAATRLFRSD---GC GGS-FYTLESLNLQ---------ARSMITTHPTLVLLWC-----------------QILL LVNHTDYR-WWAEVQQTPKRHSLSSTKLLSPQMSGEEEDSDLAAKLGM---CNREIVRRG ALILFCDYVCQNLHDS------EHLTWLIVNHIQDLISLSH------EPPVQDFISAVHR NSAAS----GLFIQAIQ-----SRCENLSAPTTLKKTL-QCLEGIHLSQS---GAVLTLY VD-RLLCTPFRVLAR-------MVDILACRRVEMLLAANLQSSMAQLPMEELNRIQEYLQ SSGLAQRH---QRLYSLLDRFRLSTTQDSLSPS-------------PPVSSHPLDGDGHV SLETVSPDKDWYIHLVKSQ----CWTRSDSAL-------LEGAELVNRIPAED-MSAFMM NS--EFNISLLAPCL-SLGMSEISSGQK----------------------------SPL- ----FEAAREVTLARV----SSTAQQLPAVH---------HVFQPHLPAEPAA------- ------------YWSKLNDLFGDAAPYQSLTTLARALAQYLVVVSKLPTHLYLPPEKEKD TVKFVVATLEALSWHLIHEQIPLSLDLQAGLDCCCLALQ-LPGLW--------------- -------------------SVISSTEFVTHACSLIHCV---------------HFILEAV AVQPG------------------EQLLSPERRMNTPKAIR-EEEEVDANTQNP-TYVTAA ---CEMVAEMVE-----------SLQSVLALGHKRN------------------------ ---------------------SSVPAFLTS--VLRNIIVSLARLPLVNSYTRVPPLVW-- --------KLGWSPKPGGEFGTA-------------FPEIPVEFLQEKEVFKEFIYRINT LGWTSRTQFEETWATLLGVLVTQP--------LVMEQEES----PPEEDTERTQINVLAV QAITSLVLSAMTVPVAGNPAVSCLEQQPRNK-PLKALDTRFGRKLSIIRGIVEQEIQAMV S--------KRENIATHHLYQAWDPVP-SLSPAT-TGALISH---------EKLLLQ--- --MNPERELGSVSYKLGQVS----------------IHSVWLG----------NSITPLR EEEWGEE--------------------------EEEEADTPAPSSPPTSPVNSRKHR--- --AGV-------------DIHSCSQFLLELYSRWI--------LPSSSA-RRTPAILISE VVRSLLVVSDLFTERSQFELMYVTLTELRRVHPSEDE----ILAQYLVPATCKAAAVLGM DK-------AVAEPVSR-----------------------LLES-TLRSSH--------- ---LPSRVGALHGILYVLECDLLDDTAKQ--------LIPVISDYLLSSLKGLAHCVNT- ------------------------------------------------------------ -------------------HSQ-QHVLVMCATAFYLIENYPLDVG----------PEFSA SIIQMCGVMLSGSE-ESTPSI----IYH------------------CALRGLERLLLSE- -----------------------------QLSRLDAESLVKLSVDRVNVHS-PHRAMAAL GLMLTCMYT-------------------------------------GKEKISP-GRTSDP NPAA-PDSESVI----VAMERVS-----VLFDRIR--------------KGFPCEARVVA RILPQFLDDF---------FPPQD-------IMNKVIGEFLSN-QQPYPQFMATVVYKVF QTLHSTGQSSMV-RDWVMLSLSNFTQRTPVAMATWSLSCFFVSASTSPWVAAILPHVIS- ------------------------------------------------------------ ---RMGKLE-QVDVNLFCLVATDFYRHQIEEE------LDRRAFQSVFEMVAA---PGSP YHRLLTCLRNIHKVSTC-------------------- Chrysemys_picta_bellii -----MATMEK------------------------------------------------- ---------------------------------LMKAFESLRSF---------------Q QQQGP-------------------------------------------AAILEEPLQRAK KELSTTKKDRVNH-CLTICENIVAQSLRNSPE-FQKLLGIAMELFLLCSDDAESDVRMVA DECLNKVIKA-----LMDSNLPRLQLELYKEIKKNGASRSLRAAVWRFAELAHLVRPQKC -RPYLVNLLPCLTRISKRPEESV-QETLAAAIPKIMAAFGNFANDNE-IKVLLKAFIANL KSSSPTIRRTAAGSAVSICQHSRRT-QYFYSWLLNVLLGLLVPVEDE-HPTLLILGVLLT LRYLIPLLQQQV-KDTSLKGSFG----------VTRKETEISP-SPDQLIQVYELTLHYT QHQ---DHNVVTGALELLQQLFRTPPP-----------DLLHALTTSGGITQ-------- -------------VSVSKDESISRSRSGSIVELIARGGSSCSPCLSRKLKGKVLLGEEEG LEDDPETRSEVSTATFAASMKSEITSELAS-SSG----VSTAGSIVSSAADPTGHDIITE QPR-SQHTLQS-DSVDLTSCD-----------LASTTTEGEEDDMLSRSSSQISTVQSDP TMDLNDG-TQ--------------ASSPVSDSSQTTTEGPDSAVTPSDSSEIVSVQRAER VSQSSTEGPDISQSSSMEGPDLDTSTYSSSTFLSSASNTEK--------------VLEGT ESQYSGMQIGQLQDEE-DE-TANVL----------------------------------- --HDESSDPFRNSSLALQQPHLLKNM-------------------GHSRQPSDSSVDRFM AKEEAVESVDHEIKPSRIKGDI----GHYTDG---NSAPLVHCV---------------- -------RLLSASF-LLTGEKGALVPDRDVRVSVKALAVSCVGA-AVALHPESFFSKLYK TP---------------------------------------------------------- ------------------------------------------------------------ -----------------------------LETMGEEYEEQ-----YVSDV---LNYIDHG DPQIRGATAILCGTIVYSI----------------------------------------- --------------------------------------------LNKSRFDVENWLANVR SSTGNL-F---SLVDCIPLLQKTLKDE-SSVTCKLACAAVRHCIMNLC------------ -SSSYSELGLQ--------------------------------------------LIIDL LTLKNSSYWLVRTELLETLAEIDFRLVSFLEGK----ADNLHRGVHHYTG---------- -----------LLKLQDRVLNNVVIYLLGDEDPRVRHIAAASLMRLVPK----------- --------------LF--------------YNCDQG---------QADPVVAVARDQSSV Y-----LKLLMHETPPPSHFAVSTI-TRTYRGYNMVQSPTDV-TMEN-NLSRVISAVSQA LTTSTTRALTFGCCEALCLLSTTFPVCTWTVGWHC-GYVSSSSIQASRIHVYKNRGHSFS TSQLSPS----------EESRKSCTI------GMAGMVLSL--LSTA-------WFPLDL SAHQDA----LILAGNLLAASAPKSLK--TPWTTEEDMNPGAA-------KQEEPWPALA DRTLVTLVEQLFSHLLKTINICAHVVDDV-APGPAI--------------KATLPSLSNP P----SLSPIR-------RKGKEREPVEQTSVPMSPK----K---GSETNPATRQTDTSG PAPT--SKSSSLGSFYHLPSYLKLYDVLKATHANYKVTLDLQNNIEKFGGFLRSALDVLS QILE--LATLQDIGKCVEEILGYLKSCFNREPMMATVCVQQLLKTLFGTNLASQYDGLSS N--PS---KSQGKAQRLGSSN--LRP-------GLYHYCFMAPYTHFTQALADASLRNMV -QTEQEHDASGWFDVPQKVSTQLKTSLTNVTKH-RADKNAIHNHIRLFEPLVIKALKQYT TTTSVQL-QRQVLDLLAQLVQLRVNYCLLDSDQVFIGFVLKQFEYIEVGQF--------- -RESEAIIPNIFFFLVLLSYER--Y-----HSKQIIGIPKIIQLCDGIMASGRKAVTHAI PALQPIVHDLFVL-------------------------------RG--TNKADAG----- ------------------KELETQKEVVVSMLL-RLIQ---YHQVLEMFILVLQQCHKEN -----------EDKWKR---------LSRQIADIILP----------------MLAKQQM HIDSHEALGVLNTLFEILAPSSL---RPVDMLLRSMF----------------------I TPCT----MASVSTVQLWISGILAILRVLISQSTEDIVLSRIQ----------ELSFSPY LLSCQTI-NRLRDGENNVPTPE--------EQIELKQAKYLPEETFSRFLLQLVGILLED IA--TKQLKVDMNEQQHT-FYCQELGTLLMCLIHIFKSGMFRRITAAASRLFTGD---GS DGS-FYTLESLSGL---------VQFMIPTHPSLVLLWC-----------------QILL LVNYTNYS-WWSEVHQTPKRHSLSSTKLLSPQISGDSDEFDSESKFGM---CNREIVRRG ALILFCDYVCQNLHDS------EHLTWLIVNHVQDLINLSH------EPPVQDFISAVHR NSAAS----GLFIQAIQ-----SRCENLATPTTLKKTL-QCLEGIHLSQS---GAVLMLY VD-KLLCTPFRVLAR-------MVDTLACRRVEMLLAATFQNSVSQLPVEELDRIQEYLQ NSGLAPRH---QRLYSLLDRFRLTVAPETTSPS-------------PLVTSHPLDGENQP ALENVIPDKDWYVSLVRSQ----CWVRSDSAL-------LEGAELVNRIPQPE-LNSFMT SK--EFNLSLLAPCL-SLGMNGISEDQK----------------------------SSL- ----FETARRVTLDHV----CNIVQKLPASH---------QVFQPLQPVETSA------- ------------YWSKLSDIFGDTMLYQTVMKLSRALAQYLLLLSKLPASLCIPPDKETD ILKFVVMSLEALSWHLIHEHIPLSIDLQAALECCCLTLQ-QPGLW--------------- -------------------NLLASAVYVTQACSLINCV---------------RFIIEAV AIEPG------------------NQLLSPERKKNTSKGVN--EDEVDSNAQKA-KYITTA ---CEMVAEMVE-----------CLQTVLALGHKRN------------------------ ---------------------NSIPAFLTP--VLKNIIISLGRLPLVNSYTRVPPLVW-- --------KLGWSPKPAGDFGTA-------------FPEIPVEFLQEKEIFKEFIYRINT LGWTSRTQFEETWATLLGVLVTQP--------IVMDQEEN----QQEEDTERTQINVLAV QAITSLVLSAMTIPVAGNPAISCLEQQPRNK-ALKVLDTRFGRKLSVIRGIVEQEIQAMI S--------KRDNIATHHLYQAWDPVP-SLSPAT-TGGLISH---------EKLLLQ--- --INTEREMGNMGYKLGQVS----------------IHSVWLG----------NNITPLR EEEWDED--------------------------EEDENDMPAPSSPPTSPINSRKHR--- --AGV-------------DIHSCSQFLLELYSQWI--------LPSNPS-KRTPVILISE VVRSLLAVSDLFTERNQFEMMYTTLTELRKVHPSEDE----ILIQYLVPATCKAAAVLGM DK-------AVAEPVSR-----------------------LLES-TLRSTH--------- ---MPSRIGALHGILYILECDLLDETAKQ--------LIPIISEYLLSNLRGIAHCVHV- ------------------------------------------------------------ -------------------HNQ-QHILVMCAAAFYLIENYPLDVG----------PEFSA GIIQVCGVMVSGSD-ESTPSI----IYH------------------CVLRGLERLLLSE- -----------------------------QLSRLDSESLVKLSVDRVNIHS-PHRAMAAL GLMLTCMYT-------------------------------------GKEKISP-SRATDA NPTA-PDSESVI----VAMERVS-----VLFDRIR--------------KGFPFEARVVA RILPQFLDDF---------FPPQD-------VMNKVIGEFLSN-QQPYPQFMATVVYKVF QTLHTTGQSPMV-RDWVMLSLSNFTQRTPVAMAMWSLSCFFVSASTTQWVSAILPHIIS- ------------------------------------------------------------ ---RMGKSE-QVDINLFCLVAIDFYRHQIDEE------LDRRAFQSVFEMVAS---PGSP YHRLLTCLQNVHKITAC-------------------- Ciona_intestinalis --------MEK------------------------------------------------- ---------------------------------LVKSVNALKFF---------------- ----------------------------------------------YGGLSSED---KTQ KDALQSPNERQSH-CNIVLESIISPSIRSLAD-YPGLLAVSVETLLQSCADDNADVRLNA NECLNRLIKG-----LYEISNSKILVELYKEIKKNGHPRSLRAALDRFSRLSHNIRSNKC -RPYILNLLPCLCRISQREEDGV-QETLGLSLVKIFKILGPFASESE-IQGLLASFLKNL SHKSATMRRTACVCLHSVILNCRKQ-NLVIGPLMNSILDILLQRNTD-RNT--VLGCLQA LRILSPLFETCV------PGKIS-------------EQHILNE-HRDLVLKVFDACVFYL DNT---DHTIVTAALELLEHLLNEFSS-----------ELASVLIVCGKLKP-------- -------------TS---------------------------------------FTPSTV LPDEVETKAT-----------------------------------------SVTTDEVSS LSSLASSTIED----------------------------------------KLSCIRLLP VEDQDPP-----------------SNPLLPHNEQTS------------------------ -------------------------------------------------------QTNGA TEHKDQTEPSDLD-------QTITN----------------------------------- --HDEDAK--------------LPEN-------------------GHEESLSESSLEKMA S-DPISTSSDL------IPVSH----LYATES---STLPIITLA---------------- -------RMLCQRF-LLSMETGEVLPDKQVRVSNKNLTMNTLSQ-LVKIYPAAVCHSLLY ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------YESSSQ-----YMTNV---FLYSTHS DPKLRGSAVTLASVFIDAV----------------------------------------- --------------------------------------------VTRNRKGIKDWFKNVE RNSSTS-LKCPTIEDLISLIHGGLIDE-SSTTTRQACSAVTSCVHTLL------------ -NSMYFSYGLE--------------------------------------------LLHMV VGLQSSTYWLIKVSLLELLASLNYRQIAYLELLSKRDAASVKTQSLPHQA---------- -----------L---------SIALKCLCDDDLRLRKTAAATIVTM-PT----------- --------------SF--------------PTPNEL---------YGDLLTSEAAEMTRQ WMGGSEMRNEDEEEQSNDAGSAKSL-LKTYRGYEM-DCKNSG-SITD-SLSYIVGEVSTM LTNSSNKHQTYGCLLALKQLSIKYMVSNHPVAWGCYAVTDDRSRSSSNESETSSNSSDSK IPKRQSS----------NPNGSQQQF------GILPFVMSL--LHSA-------WLPLDV TAHSDA----LVLAGNLVAGAASDGLKVFGPVAIEDQSFEKVS--VKTVTSNARSWATIY DPVLGSYANQLFTHLTRLSSIMHHVISEV-TPSPPN--------------KSVLPNIAPG N----IPSPIK-------RKEKAPGEQNRSSPPLTRK----LLPTSSLGKPGNKENQDEK PTKK------LIGSFYNNRTLMRLFDQLTGSYKNYKVSLEF-GCDDRFCSFLSSTLDVLS QVLE--LAVFQDIGSYTEELLNYMKSLFTVEPTLTIQSVQQLLKALFGTNLVSNMIPHDD SKPPN---PPTSPIL-LNSTA------------GFYHQIFHHPLNHLTMAIANSSFHHSL QTKSPPKENDGWFGSIKK---KVEKKLNDVSKNSKGSKSSIQNYIRLFEILVIKSLKLYT TTSSVEFQQKHVLNLLAQLVQLRVNYCMLDSDQVFINFIIKQFESIEGGLV--------- -RGSESLIPHVFFFLVLLSYER--Y-----RTKAVITMPKIIQLCDGLMASGQGSASHVI PAMQPIIHDIYVV-------------------------------RA--SSKNEP------ ------------------PEVTTQREVVQFTLL-KLLQ---HPQVFKMLITILVHGRREN -----------VEKWKK---------YSRQVADVLLP----------------LLSQLKV NVTSHDDVSTLHSLFEAISPSAL---RPIGLLMDLLL----------------------K MPKS----LNSISHIHRWLTNILVLLRVLICQASEHDILDNID----------LSKVKIK HMTCTHM-EYLHSDQTS---QE--------EEEQNMNEVFSPADILAMFFHQVIGSCCST LLHYSTNPRTKSDESSQI-LLSQQINELFLALTYIHRSGSFKNLTSACKKVSSTN---LN G---FYTSDQMVST---------FLHLTYSHPIITVMWA-----------------QYLS HFVPVTAQ-FWEN-------------------FTGCKDTNDF-----P---LNRNIVKKG CVILLADYVCQNSNQS------ELSLWLAEHHVNDIIMMSE------EPPVQDFLTSVHL GAEES----ACLIKAIS---KLSKTQQNIKVSFILRIL-KCLSGVSIKSS---ESLISLL LSPKFLFSPVRRVFA-------ASLLFLQSTVENILELNKEEALEIIPTE----FTQNLM QKGESLKE---KSQYILFCDLISQLHSHVTGEQ-------------PITSEKP---GPTI QALMEKPNQNWFNSVILSCLDENRWT-------------PECARVLACADFDD-IIDIQG NN--NFTAQHLASCL-YNGIHEVTSMHGALIPYPEDKT------------------SNL- ----LAASLLTLDKKI----KAVLEITPGNT---------EFDTPLMDNSNTE------- -------------IKFIGDKN----FQQNLMWLNRCLVNMLKFHHILPTQYQLPNVNSND YLNIIVLGFKVTQYGIHKGKIPSLQDIVCVLESLQQALA-VQSLH--------------- -------------------AM-----FINEVKWMLQTV---------------QVLFTIM EIYIG------------------RISYEP---PYLPSCID--KEEASSIYNNS-SNPLSS ---CIKLYQML---------------SLFRRQHKNK------------------------ ------------------EMFAKIPTYIVR--PINNIILHLATSPLFKNYVRTPLVVW-- --------TFGWNPALGGDTGTS-------------LPEIPSDFLQEKEVLQEYIAIVNQ IGWTKRTEFEETWASLLGVLVSQP--------VVSDESSG--------EAMHTEISSLAI RGLTSLVVDCALYPECGRKATSKYQVFYRHP-TFKLGNTKAGRQLLKVRGILDDESRFMT Q--------RKSHQDTHHQNTSLNDSS-NLSSSLQSNKWIT------------------- --MNTERVLSSSAYGLAQSS----------------VRSFHLL----------HGITPMK EELYDGDYDSATMHSFEYDNSLSNDGSDVSDMFETSEAETPDVPTNPAPPLSPLRIR--- --DGV-------------DVHSCVQFLLELYTEWFRTTAQTNQISGSSSTIARP--LLCE CVRSLLLISDLFTEKQQFEWMFVALTTLHNAQPADDD----ILMQYITPSMCKAGSVLGL NS-------ETSENVLR-----------------------VLEP-SLRSTL--------- ---LSCRTSALVGLLQCIESY-PNPNLRG--------IIDLASQFIPPNFVAISTCPSL- ------------------------------------------------------------ -------------------FNE-DYVVLLASVAFYIIEKCHDAVM----------PEFTS VIIQACTLIISSRDVTSVQSR----VFH------------------SVTHGLQRLILSF- -----------------------------SISASECDSILKVAAEQVHTNPWLPRATAAC GLMMTCMYC-------------------------------------GRMRISSNPDHGSP HGGS-PEHEDVVESRLLAMERVT-----LLFERIR--------------KGYPHEARVMS KVLPSMLDDF---------FPAQD-------IMNKIIAEFIST-LQPFPASVAQILYEVF QSLLERDQSHLV-QEWVMLSLGNAIQRTPLQTAVWCLTCLFSSASTNRWISSMVPLIIS- ------------------------------------------------------------ ---RVHDPTLDVNWTFFCKAAVDFYTCQLSEE------LDRRSFHAIFSTSSSSREPGSP YKLLLDCISRINGEQGILQ------------------ Danio_rerio -----MATMEK------------------------------------------------- ---------------------------------LMKAFESLKSF---------------Q QQQ--------------------------------------------GPLSAEELVQKQK KDLATTKKDRVTH-CLTICENIVAQSLRTSPE-FQKLLGIAMEMFLLCSDDKESDVRMVA DECLNKIIKA-----LMDSNLPRLQLELYKEIKKNAASRSLRAALWRFAELAHLVRPQKC -RPYLVNLLPCLTRITKRQEETV-QETLSSSIPKIMAALGHFANDGE-IKMLLKAFVANL KSSSPTIRRTAASSAVSVCQHSRRT-HYFYTWLLNVLLGLVVPVDEE-HSSHLILGVLLT LRYLMPLIQQQT-PSTSLKGSFG----------LVRKEADVTP-APEQLIQVYELTLHYT QHW---DHNVVTASLELLQQMFRTPPP-----------ELLNVLITRGKITH-------- -------------TSVFREEVESRARSGSILELIAGG-STCSPLLLRKQKGKLLSGEEEG LEDDPE-RAEVTTGSFTASVGGDSSSEAPS-SSG----VSSLG----------TSDIITE QPRSSQHALQPGDSVDLSASEQGVG-------PDTPDE-EDEEDMLSRSSSGGAGLVSTS GDLVTDA-NQMSAGAV--------SSSPPSESSQTTTEGPDSAVTPSDCAELVSVTSTSR RYRKYSPPSPTLTEGPDTQSESGSSVYRPSSSSTSSTSSSSSTFSAISSSSSSDQVLDGS ESQYSGMQIGTLQDEE-EEGSA-PP----------------------------------- --PDKPPEPFSQSALALSKPHLLEGK-------------------GHNRQSSDSSVDRFI PKEEVLEPAELDNKPSRIKGDI----GHYTDP---KEEPLMHCV---------------- -------RLLAASF-LLTGQRNGLVPDNEVRVSVKALAVSCVGA-AAALLPEAFFNLLYL QP---------------------------------------------------------- ------------------------------------------------------------ -----------------------------LDGQ-QTEEQQ-----YISDI---LQYIEHG DHQIRGATAILCGALIQAI----------------------------------------- --------------------------------------------QLKTRYNTETWLSQIQ SVTGSS-V---TLENFVPLLQRSLKDE-SSVTCKMACAAVRHCIMALC------------ -NGSLSELGLQ--------------------------------------------LLIDL LTLKNCSYWLVRTELLETLAEIDFRLISFLERK----TEKLHKGEHHYTG---------- -----------LLRLQDRVLNDVVLYLLGDEDPRVRHVAANTIGRLVPR----------- --------------LF--------------FDCDQG---------QTDPVVAIARDQSSV H-----LQLLMHETQPPSQFTVSTI-TRTYRGFNLCQSAPDV-TVEN-NLSRVITAISHA LTSSTSRAMTFGCCEALCLLSSTFPVCNWSTGWHC-GFVSSSVFHLNRSSQYRSRGRSFS LSQSGSN----------EEVRRSLTV------GVASMVLSL--ISSA-------WFPLDL SAHQAA----LLLAGNLLAAVAPKCMK--SPWAGEEESSPASS-------KVEEPWPALN DRSLVVMVEQLFSHLLKILNICAHVLDDT-PPGPAV--------------KASLPSLANT P----SLSPIR-------RKGKEKDMMEAGTTPMSPK----K---GGESN-TGRAADSTA TAAV--NKSTTLGSFYHLPPYLKLYDALRATHANYKVTLDLHNPNEKFGGFLRSALDVLS QLLE--LATLHDIGKCVEEILGYLKSCFSREPTMATVCVQQLLKALFGTNLASQYEGASS N--PC---RSQGKALRLGSSS--VRP-------GLYHYCFMAPYTHFTQALADASLRNMV -QAEQEQDASGWFDVMQKVSNQLRSSITNVTRH-RGDKNAIHNHIRLFEPLVIKALKQYT TSTSVAL-QRQVLDLLAQLVQLRVNYCLLDSDQVFIGFVLKQFEYIEVGQF--------- -RDSEEIVPNIFFFLVLLSYER--Y-----HSKQIISIPKIIQLCDGIMASGRKAVTHAI PALQPIVHDLFVL-------------------------------RG--SNKADAG----- ------------------KELETQKEVVVSMLL-RLIQ---HHQVLEMFILVLQQCHKEN -----------EDKWKR---------LSRQVADIILP----------------MIAKQQM HLDSHEALGVLNTLFESVAPSSL---RPVDMLLKSMF----------------------I TPST----LASVGTVQLWVSGILAILRVLISQSTEDIILSRIQ----------ELSLSPY LLSCPTI-RRLCDDDVP-APPETLPVA--MEDANGETPRFPPEETFARFLLQLVGVLLDD IA--NKQVKVDMSEQQHT-FYCQQLGTLLMCLIHIFKSGMFRRITAAGSKLLKAE---GG EGGDFYTLEGLNSL---------VLQLITTHPSLVLLWC-----------------QVLL IINYTNYT-WWSEVHQTPRRHSLSSTKLLSPHSSGEEERPE--GKLTM---CNREIVRRG ALILFCDYVCQNLHDS------EHLTWLTVNHVSDLISLSH------EPPVQDLISAVHR NSAAS----GLFIQAIQ-----SRCDNLCTPVMLKKTL-QCLEGIHLSQS---GALLMLY VD-KLLNTPFRVLAR-------MVDTLACRRVEMLLAETLQNSIAQLPLEELDRIQQYLQ TSGLAQRH---QRFFSLLDRFRATVAEDTTSPV-------------APITTHPLDGDPPP PPENVEPNKEWYVTLVKSQ----CCLRGEGAL-------YETTELLTKLPQSD-LNAIMT CK--DFNLCLLASCL-SVGVQRVCKDHG----------------------------AVL- ----FDTAQQVTFERL----AGVIELLPSPH------------QPLLPSSKVC------- ----------PDYWQKLNQVYGEPGFYQTVLSLCGVLSQYLLSLSKLPSSMHIPKDRETL ITTFSTLAIEVVVWRLLQDQLPQSVDMQMSLSCLCLALQ-QPAVW--------------- -------------------THFTSHSYLTHTCSIIHCI---------------QLLIHAV AVGPG------------------DQFLRPERKISEQS-----EDQVDSSDNQR-EWHC-- ---CEIMAELVE-----------GLQTVLTLGHHKN------------------------ ---------------------KNIPAFLTP--TLRNVIISLARLPLVNSYTRIPPLVW-- --------KLGWSPKLSGEFGTA-------------LPEIPVEFLQEKDVFREFLYRINT LGWSSRTQFEETWATLLGVLVTQP--------ITMDQEEE---TQQEEDLERTQINVLAV QAITSLVLSAMTLPTAGNPAVSCPEQQPRNK-ILKALDTRFGRKLSVIRGMVEREIQAMV S--------KRDNIATHFPYQAWDPVP-SLSSST-AGTLISH---------EKLLLQ--- --INTEREMGNMDYKLGQVS----------------IHSVWLG----------NNITPLR EEEWGED--------------------------EEDEADAPAPASPQLSPINSRKHR--- --AGV-------------DIHSCSQFLLELYSQWI--------LPGSPSSRKTPVVLISE VVRSLLAVSDLFTERNQFDMMFSTLTELQKVHPPEDE----ILNQYLVPAICKAAAVLGM DK-------AIAEPVCR-----------------------LLES-TLRSTH--------- ---LPSRIGALHGVLYVLECDLLDDTARQ--------LIPTVSEYLLSNLKALAHCVNL- ------------------------------------------------------------ -------------------HNQ-QHVLVMCAVAFYMMENYPLDVG----------SEFNA GIIQLCCMILSASE-EATPSI----IYH------------------CVLRGLERLLLSE- -----------------------------QLSRMDAETLVKLSVDRVNMPS-PHRAMAAL GLMLTCMYT-------------------------------GVAGEEGKEKGSP-GRPADA DPTA-PDSESVI----VAMERVS-----VLFDRIR--------------KGFPSEARVVA RILPQFLDDF---------FPLQD-------VMNKVIGEFLSN-QQPYPQFMATVVYKVF QTLHATGQSSMV-RDWVLLSLSNFTQRTPVAMAMWSLSCFFVSASTSQWISALLPHVIS- ------------------------------------------------------------ ---RMGKSD-TVDISLFCLVAMDFYRHQIDEE------LDRRAFQSVFEMVAS---PGSP YYQLLCCLQSIHQDTSL-------------------- Delphinapterus_leucas -----MATLEK------------------------------------------------- ---------------------------------LMKAFESLKSF---------QQQQQQQ QQQ---------PPPPPPQPPQPPPQAQPPPQPQSPPPPPPPPPPPPGPAVAEEPLHRPK KELSATKKDRVNH-CLTICENIVAQSLRNSPE-FQKLLGIAMELFLLCSDDAESDVRMVA DECLNKVIKA-----LMDSNLPRLQLELYKEIKKNGAPRSLRAALWRFAELAHLVRPQKC -RPYLVNLLPCLTRTSKRPEESV-QETLAAAVPKIMASFGNFANDNE-IKVLLKAFIANL KCSSPTVRRTAAGSAVSICQHSRRT-QYFYSWLLSVLLGLLVPVEEE-RSALLILGVLLT LRYLVPLLQQQV-KDTSLKGSFG----------VTRKEMEVSP-STEQLVQVYELTLHYT QHQ---DHNVVTGALELLQQLLRTPPP-----------ELLRVLTTAGGIGQ-------- -------------LTAAKAEPGCRSRSGSIVELIAGGGSSCSPVLSRKQKGKVLFGEAAA LEDDSESRSDGSSPTFAASVKGEIGGELAA-SSG----VSTPG----SAADSVGHDIITE QPR-SQHTLQT-DSVDLTGCD-----------LTSGATDGDEEDILSHSSSQMSAIPSDP AMDLNDG-TQ--------------ASSPISDSSQTTTEGPDSAVTPSDSSEI-------- -------------------------------------------------------VLDGA DSQYPGMQVGQPQDED-ED-AAVVL----------------------------------- --PDEDAEAFRNSSIALQQAHLLQSM-------------------GHSRQPSDSSIDKFV SRDEAAEPGDPENKPCRIKGDI----GQSSDE---DSAPLVHCV---------------- -------RLLSASF-LLTGEKHALVPDRDVRVSVKALALSCVGA-AVALHPESFFGRLYR AP---------------------------------------------------------- ------------------------------------------------------------ -----------------------------LDTM-EYPEEQ-----YVSDI---LNYIDHG DPQVRGATAILCGTLVSSI----------------------------------------- --------------------------------------------LSRSRFHVGDWMGTVR TLTGNT-F---SLVDCIPLLQKTLKDE-SSVTCKLACTAVRLCVMSLC------------ -SSSYSEWGLQ--------------------------------------------LLTDM LALRSSSYWLVRTELLETVAEIDFRLVSFLEAK----AENLHRRAHHYTG---------- -----------LLKLQERVLNNIVIYLLGDEDPRVRHVAAASLTRLVPK----------- --------------LF--------------YKCDQG---------QADAVVAMARGQSSV H-----LKPLMHEAQPPSHFSASTI-TRIYRGYNLLPSITDV-TMEN-NLSRVIAAVSHE LITSTTRALTFGCCEALCLLSTAFPVCIWSLGWHC-G----------------------- VPPLSAS----------DESRKSCTV------GMATMILTL--LSSA-------WFPLDL SAHQDA----LILAGNLLAASAPRSLR--SSWASEEEASPAAT-------KQEEVWPALG DRTLVPMVEQLFSHLLKVVNICAHVLDDV-APGPAI--------------KAALPSLTNP P----SLSPIR-------RKGKEKEPGEQVSVPVSPK----K---GGEASPASRPSETSG PVAA--TKSSSLGSFYHLPSYLKLHDVLKATHANYKVTLDLQSNTEKFGAFLRSALDVLS QILE--LATLQDIGKCVEEILGYLKSCFSREPVMATVCVQQLLKTLFGTNLASQFDGLSS N--PS---KSQGRAQRLGSSS--VRP-------GLYHYCFMAPYTHFTQALADASLRNMV -QAEQDHDTSGWFDVLQKVSTQLKTNLTSVAKN-RADKNAIHNHIRLFEPLVIKALKQYT TTTSVQL-QKQVLDLLAQLVQLRVNYCLLDSDQVFIGFVLKQFEYIEVGQF--------- -RESEAIIPNIFFFLVLLSYER--Y-----HSKQIIGIPKIIQLCDGIMASGRKAVTHAI PALQPIVHDLFVL-------------------------------RG--TNKADAG----- ------------------KELETQKEVVVSMLL-RLIQ---YHQVLEMFILVLQQCHKES -----------EDKWKR---------LSRQVADIILP----------------MLARQQM HIDSHEALGVLNTLFEILAPSSL---RPVDMLLRSMF----------------------V TPDT----LASVSTAQLWIAGILAILRVLISQSTEDIVLSRIQ----------ELSFSPY LLCCPII-NRLRDGGSN-SVLE--------EHSEGRQTKDLPEETFSRFLLQLVGILLED IV--TKQLRVEMSEQQHT-FYCQELGTLLMCLIHIFKSGTFRRITAAASRLLT-D---GA DGS-FYGLESLNAW---------VRSMVPTHPALVLLWC-----------------QILL LVSHTDYR-WWAEVQQTPRRRSLSSTKSLSPQMSGEDEDSDVASKLGM---CNREIVRRG ALILFCDYVCQNLHDS------EHLTWLIVNHIQDLISLSH------EPPVQDFISAVHR NSAAS----GLFIQAIQ-----SRCENLSTPTTLKKTL-QCLEGIHLSQS---GAVLTLY VD-KLLCTPFRVLAH-------MVDTLACRRVEMLLAANLQNSTAQLPAEELSRIQEHLQ SSGLAQRH---QRLYSLLDRLRLATAPASRGPA-------------PLVTPHPLDGDGPL ALETVSPDKDWYVRLVKSQ----CWTRSDSAL-------LEGAELVNRIPPGD-LNAFMM NS--EFNLNLLAPCL-GLGVREICAGRK----------------------------SPL- ----FAAARTATLDRV----ASVVQQLPAVH---------HVFQPFLPAEPTA------- ------------YWSKLDDLFGDAVLYRTLTTLARALAQYLLVFSRLPGHLHLPPEKERD TVKFVVMTLEALSWHLIHEQIPLSLDLQAGLDCCCLALQ-LPGLW--------------- -------------------SLLSSPEMVTHACSLIHCV---------------RFILEAL VVQPG------------------DQLISPERRTNPPQAAR--EDEVDSNTQNP-QYVTAA ---CGMVAEMVE-----------ALPLVLALGHKRN------------------------ ---------------------SSAPAFLTP--VLKNIVISLARLPLVNSYTRVPPLVW-- --------KLGWSPKPGGDFGTV-------------FPEIPVEFLQEKEVFKEFIYRINT LGWTSRTQFEETWATLLGVLVTQP--------LVMEQEES----PPEEDTERTQIHVLAV QAITSLVLSAMTVPVAGNPAVSCLEQQPRNK-PLKALGTRFGRKLSIIRGIVEQEIQAMV S--------KRENIATHHLYQAWDPIP-SLPPAT-TGALTSH---------DKLLLQ--- --VNPERELGNTSYNLGQVS----------------IRSVWLG----------SSVTPLR EEEWAEE------------------------------EEAPAPSSPPTSPVSARKHR--- --AGV-------------DIHSCSQFLLELYSRWI--------LPSSSA-RRTPVILISE VVRSLLVVSDLFTERSQFETMYLTLTELRRVHPSEDE----ILQQYLVPATCKAAAVLGM DK-------AVAEPVSR-----------------------LLES-TLRSGH--------- ---LPSRIGALHGVLYVLECDLLDDTAKQ--------LIPVISDYLLSSLKGAAHCVSI- ------------------------------------------------------------ -------------------HSQ-QHVLVMCATAFYLIENYPLDVG----------PEFSA AIIQMCGVMLSGSE-ESTPSI----VYH------------------CVLRGLERLLLSE- -----------------------------QLSRLDTESLVKLSVDRVNVHS-PHRAMAAL GLMLTCMYT-------------------------------------GKEKISP-GRTSDP SPAA-PDSESVI----VAMERVS-----VLFDRIR--------------KGFPCEARVVA RILPQFLDDF---------FPPQD-------VMNKVIGEFLSN-QQPYPQFMATVVYQVF QTLHSTGQSSMV-RDWVMLSLSNFTQRTPVAMAMWSLSCFFVSASTSPWVSAILPHVVS- ------------------------------------------------------------ ---RMGKLE-HVDVHLFCLVAADFYRHQIEEE------LDRRAFQSVFEVVAA---PGNP YHRLLACLRNVHKVTTC-------------------- Drosophila_melanogaster MDKSRSSAYDK------------------------------------------------- ---------------------------------FVGFVEQLRNT---------------- ------------------------------------------------------------ ---ECSQKQKITC-FQQIAECIMSPSLAGHIN-YAAHCGTATNVLLLFCEDVDSVVRMSA EENLNKILRS-----LEKTRVSRILMDLYGEIKRNGNQRSLRICLNLFSYYAPQIKEKHI -KWYAVRLLQCMTTISQRKETLL-QETLCDFVKHFSRHIQQGLSDSE-SCKLFETFLDQI SSDCAVKRRCSAQNCMSLIENARNR-SLMARHGVNKVMELLLTD----QQANSVLGALGL LRLLLPQLIRGY-PGDSHEDSES-------LAGKKQQQQQTTTSDCRQIIEIYDYCLHLL STQHTANHAIINATLEVINGILQAVDAASDGQCSQSLGQSLRQLLCNQQLQHNEYLRRRK SLKNQIFQLKNYEVATSQHQLEDEDENEDVDELVVGATAMQMKKNSNAKLQQAKCREQQQ HQHQQQLEVDNSSLGINAGEDAPTEAPSSVADEGGEPESTKLRCHIRNAARSISECVASD EDKQGQGHRQQRDEDGVVVAED----------DDDDDDDDDDDDDMELLSAECDDFTTLS QLNEQQQ-----------------ALSAALKLPTTTAASSGGAATSQDDKLIDVDADVGG LPKPQHQSSLQNLLAGSDDKSQHLSDIDNESFNSIDFDAEI--------------TIAGS KEQQQQHPPADDSVESGDATAIGTFFNNLLSHSNAASESVSKLFRQSSGSKSTPSKSAST PAPADKSDAISAASLTLSLTSLASSNLEPPERQPLIAETPTPVEDSCSITASHTASTALM MDAPAVEVAASKPETPQLRGTP------NANPFLVENSPLRQTVVGRALITVKIGSILEQ SLVYYTARLVAARF-LLSGQAAGLQPDSISRVSIKSLSLAVIAQ-CVRLAPKILQLSLEI SEQELQLLEEATSQIGSGDSTQVSSPQSSDNSQVGGEKPPLDSSLVPTSLEENLLLLDIK DDHFGPSTCPAYLQSATPTLSRSADASVLLLEGGTTSSRSAKKSEEMLSKSEIIESSYRP TVAVEDVPPLSMPPRPPKRTKSTRSRVGVLGTSSTTESSSPQSRQKLSDI---LLFHDHC DPILRGGVQQVVGNFLQSSGAGLFLDLQRGLGLQHLLAILLKGFEDEIHTVVIQALNAFD KIFPNVVSKYLTEPPCHYHAHQQQQQQQKEQQQQEQDNQKLEQDLQRHSSGQQKRSGQAQ TFGQQT-F-AKDQDNALSSQRQQQRRPNDAGTCANSSATDNDELL--------------- -AALLNDFQLQSTGMRQQPKNNSTDTGQSGNEPDLEPNPNAAVEPFCVFAISPKLLLSKL RLCHHNKYWLVQNKYAEVISNLNYVLLRSYYANFRCAIDNKNSGARKQDSKWPPMDASSV CHSVRDAEGEDIVCTYEAQFLAELLHLLGDDDARVREHAACCLCRFIMQ----------- --------------TA-----------RQDPSQDQGAGGGGGDDIEGNGNVNVETQQTNF N-----LLWDFFDYRIFGSMSVTLR-NLFRASSTIVPPLAELDALATSNSAPSYPDTGST SGSSTSTSASSGGSAAAVSAASAYFEASYGIGIAE-GHVFALASASQRQIAQEEKVLAKV LYRLTNKLM--------TLNDKNVQFGIIYALRLLLRHFNFVDYQQV-------WLEFNF VE--------ICISYAYYNNATAADLG-----CQNDLIDVMGK-------LMAGAMLSSG EPN-TAHLDFLLRHSVKMLNIYYHLVTNQ-----------------------------RP P-----------------TAGSQSGS-------------------SSSKQPKSELFAREQ PAAT----LQALGYFAGDYVYMKLYNILRGANDSYKITIN-QEAGSLLICLLKTCLHAVS LCLEGMASASPPELKLIEEILHYLTRLINYAPAECVACLRQLLKYLFAQNYASQVRLQ-- ---PS---AIGGNGSEIGHHAAFMRPYFAAKGRGHGASSTLLPTINSKPAVAVGSQRGAP TDARQPIDAGPLQDMGMLFVHGLQPPTPPAGDCVR--------LIKLFEPMVIYCLTLFM KSNALV--QAPILRLLSQLLDLNVTYSILDSKNVIFDQVLSNMDLIEGGID--------- -RNAFIMVPPMLRFLVQLTHKS---------DRQLITIPKIISITNNLLANG-SVRVVAL LALKTLSYELFFM---------------HSQLEEALDTEGHNSGRD--ACQSPLSAAPTP ETREALLAQR--------RELDTQREVVLGMLE-KFIEARPSQQVLALLLLFERSVQQLD -----------TPPYRS-----------AQDADAVYG------------TLCRGLCSRQW RLHNAGDLRLLESCFRNNGNHVLADSKRFLQLLQ-LFIEQGVGNFGDLALAMVMLSNVIL KTEE----IYLVNHIKLYLKNNPTAERRLQA----------------------LMPSSPS AAPHWQD-EAPSTSSAAAAARAAA------ASFSAGRSSISEINYFAKVLCEKLLACLEV LL------GLEPSSSSHA--YCQLTGRFMDALLNVCCRSRHKDALQSVFRLVLAE---SE FLCKYYSLLLMSA----------AGLVGSYLLDAVLLAC----------------LRLVL AMRLEEPVALLEQAAQLPLKTNLQRA-------------------------LLREVCRAS AG---CDWSAQQVRRLFEG---RYLNFLIADHLEFICELCQ------ERP---------- -----------------------ECGSLLQVALFR-----NAHRLSRQSV---RIVLRLL GR---LCEPAEREASGDVGSDADPTLQAMQLLSRLHQLYEGERSLQLPIERMARRLS--A QSGQPARNVIYERLVE--GDLAGGEDQDALRTL--------------LLKDLECRQDNET ATPSRIIDESWLFAQLIKF----ATQHADAPQQQ-----KQLMLLLLEIQSEPKLQRLLR SLGTEHEAKLLRHAI-AGSLAAMMSAFRQKCIQHAPHINYMQP-------------TPL- ----ARVSCALLMSRVASTEATKCRNPPTGE--------------QLDVARAV------- ----------GALMACIRNAEQTALIYIDARLMEKFVVEHLLRREHLPQLL--------A YLGWLAGAAKQIL-AMPTRQESEQDALGVLLATVNTLLQ-QPRVW--------------- -------------------RELNASSDPSLRCELLDLL---------------DSVARCI LQD--------------------TIFYRRHRRDRNKA-----------------KGPAPQ ---AIFLAKLIE-----TQIEIESLASGRVLAGVEE------------------------ --------------ARLQFAGQDLARFQVALSLVTSIGISLLRTHQFYAYAVTPHELI-- -------------QQPGDQQQEQ--------QADGKLPSIPVDSLSDVDVLRQFVKRLSI FGFTTRQQFEEYFMTCL---------------LLINKLYD---EHMVDQQEQFQIKQVCL QAILELLMTYKTFPIVG-LANGQFHHTTRWQ-RITC-DSISLKKLHKVQLLVDACNVFYQ P-----------NLERQLAY---------------------------------------- -----DNVIGTRTFAPNQYD----------------LNFSWAQ---------------ME DQAAAGV--------------GVGVGVGLSGGEQANTADIKQSCDADVPDMAMRNYRHFT QLSGI-------------DFRSSTQLVFDVLQQMI---------------ELNHILVLPN LVK----FCEICESRDHIKWIKERCLKLQEQVAMDDT----ISHQHIIYLLCRSQALLIP SL-------GELQVLCS-----------------------LIGNVYLKSTH--------- ---SFIRIATLQGLLCLLECCSKTNTTMGRLSEELALLRSLIVGYI--NRHGIIDESPL- ------------------------------------------------------------ -------------------PFSVEHTKLVWTLNYSLIEWTSKFVPQ---------CHLLS NTIIAANNFLKTTADEE--------LYL------------------CVLHGLERMVVNSG VPPPGIQPTGKDAAAGEPGAEGSKAGVGVVVTPQMRHKIEKLALELLKMEN-EKFSIPAL KLLLSCMYV-------------------------------------GSAAQLE--NTELS NGIV-QDDPEIIA---QQNDKVD-----ILLHCIK--------------SSTRDAAWIYG QVLCQIIRDL---------VPPNE-------ILTKVIKEFLAI-NHPHCDVIAMIVYQVF RSAIDSSYLQML-QDWLICTLPTFLD-QPEQQGVWGLSVIFLSASINLHLIKLFPLVLGI GASNSAAAATTATTATTEAEAAAPA----------------------------------- ---MARKLG-QHEIALFVTAAQDFHAKLSGEQ--------RQRFREAFGSFK----RSQV YGRMLQCL----------------------------- Echinococcus_multilocularis ---MSYSSYEG------------------------------------------------- --------------------------------RLLEVFSHFGMI---------------- -----------------------------------------------QKDASEEGEDALI SVILKIPKTRLLKDIGQLTEAYLAMQSLNPSN-AVNYLSFVTGTLFELVSHPDPDVRTAA DEGINQIVKF-----ANIHLVQCVICEVFLEIKRSLHARSLSSALRKFSACIGQINPKKR -RIYAVNILPALNGLINREEEMV-WDCFAETIEPIAIFIFPHTSQQELITLLLRGLLERV ECDKNYIRRSAATILASSVVHSRLP-HELSYLLIQQLVGRVLVL----KQRFLLRGS--- -------------GGMVATAAVG---------------------LQGCLCTLRNLASLYS RIP---TTALVN---ERTKSKGRPSPS-----------TYLSASLIDLGVGI-------- -------------A---------------------------------------------- ---DFANWSRESLEFFWWSV----------------------------------VRLLCL QLACRKHQASS-------------------------------------SSTMVCTAALEC LLEILSS-TP--------------AGRPITELPEGFQEALGAFC---------------- -------------------------------------------------------STTWP HSPSAVLHLDDYDS------SVDAS----------------------------------- --DADDVSSVTSHSAIPLTSTIVESE-------------------GEKVSLVKRNL--LP PTSSTPAQRETEAPPSDLPLDAPDGPEFEDENEIVATSSLHSFL---------------- -------GLFAHRFGLLSG------AQLTARAAAQSLAVACLAKLSLTLPPELFFEPLSE E----------------------------------------------------------- ------------------------------------------------------------ ----------------------------------EGEEKK-----AVTGIEMALHLMHHS DPQVRGNACLLVGNILHST----------------------------------------- --------------------------------------------ATYA------LIKPTS SLNMHQHL---QIYRLISGLDDLLASERSGITYRMALKALRSCANTLLHLPAVTSTVDME TESASVRLLQC--------------------------------------------IASRL VDCARHPYRLVRRETLLLVAGLDWDQLEHLERAWFGRHRNRTSTRLVAAT---------- -----------PLSI---VAWNECLRLFADADRSLGREAFHSLLALAKRTPSADLQRTQM SGVDLESVDTVAAHLFEHSALTGQNAVACDLPVAQG---------NYTPIVSGFTDDLRC VTKNLPVYLRFSAPPSPSTQLKSST-THRRRLWRHRHIRGLH-RVFR-ELVDSFLELSPV CDSPENRSMMHSLIFGLAELLGRPPITSNHLLWYT------------------------P SPFPQPL----------DEGNENT--------GVSPARFALQHYQRRPKMALLLWHCISQ LAISPLALTDLALQAQLLCLASGCALR----WGVSSLLEGSVP-------AGGKM-ELHH DHAFTRASGALLKHVIKLLAMFWHVFKGVKPSSTASTTSTNIISNFV---GGNLATSSVP F----ASASIG---------GASAGPSTIVTTTITTSQTKSKSIFGLQFVQTTETEEEEN RLVL--GSRETHGYFADSLEYMQLYNTIRASFEAFKSSFSEPSTEDLTMNLLAATLLAFS RLME--VLRFAEVVTWVEEVLCYLEAAFVWSPTLVLDAAVNLLRALFGTNLTSIWNPELA DKFRS---VLDPKTSTMTGAD------------GLDVQIRHLCEAHFEIAEKFCSFNTIG ------RSFLDWLYAARQFNQPAMLRPSSLPSN--IQQPNLAYYIRLFEPLVLQCLHEYH LRTDAAV-QAKILHILTVLIELGVNYSQLDEEFRFLKTVMAQCESMQHDNATASYNHKTS SKEVTQLVSNMFQFFVALTHEKKISLGTTSDAKAVLSLSEVVHLVGVLAAGGVDVDSFVV PALAPLIIDVYVV-------------------------------RG--VQYRSALRVKWQ NSQQQRLIDLKDQLFKDLCDWNAHREHLLGFLMPKFIG---HSRIFDFLCVILEDASLTD AVLKVPFDAGSDSTANK---------TATEICRHFLS----------------ALADCRL TIDTCGDVEAYLRLIKRLALPPWPTAVIHDFLLRQLI------------------PILFH RPAQGFFFKESLEQSHRWIACKFVCLRFLL-----------------------LLAIKQP STLLPALREFGACGEAD-------------PRTVLFGHLLDLLETTCEALLAHLPDFVDE VI------SNSSSPSTGE-AYPAFIGQLLLALE--LEILTFGRLHALSPSEIPQE----- ------KVERLDEL---------LMIYGRLKPLPLILWH-----------------QIRI ELFRNLSR---NDLHTAPYH-------------------------------RNSVCFRRT VFLL--NFRSKQDEPT------DDLNFSPAADLLSLLKTSE------VHGMIASVKDVEK RSVLLKEVLSTLITGVND--AKTPTEAVALLEDLKKLT-QELSGLIAHKSDRKAVLLSLL LPIEKWFFPTSQYLI-------FKLPAIRREMELLLATCLREIDKSKMDEIPETLATFLA SLDLPTTTFFTRKLPDALTDLRHRFSRAVNSEA-------TASNREGHFVESLIEAVLQK SLRVSTKDAGLLAAKLLQL------RRAKGGANLPEAVPPRLLQHIVRLGFVETMKRFNN DDVGTFGTDPLWQLGKELLFKRLSTFSE-------------------------------- ----RADGKESFLDSSQRQLAGIAAATTDFL----------LLSTRLPLPSAC------- --SKDEINSISAFLCYLMQNF--IHLTSEIKFLRPCLLSLPLLTLRLSVVLSASSDSKD- -LDFGKLPLETFV------QFAEALDVSASLSRPATLMDSHPSV---------------- -------------------EVNDDDTRLDHLISRLRCL--------------------LV PRQPG----------------IFRFTTSAYTLTRFTEVLNSFAANAGTTSGVV-GGVGAS DKSRVALASVMGLCR--------LSPAGLRYAHALK------------------------ ------------------MDSTDIAG------QFSAFLIALCRRPEVMFRLRQPSAFT-- --------HLAMGDTATNDTGGGDGCDSYTNGHQW-NPDRVIEM--DRDALAEASSWFLS LGWLNRSMFESTWNALLAVCTPPPPPPSPSSSLDVEMEENPFVNSKEELVEINHCRVLGL NALTRLLLNAAHRPRPGDPLNSSPLHQPRLSLPPQFMHTRLGGRIGCVLSRLDQEARTWF YDIPSTNAVIGSDAGKSEECLSWLSTNLDLEHPADLDSVANQ------------------ --VPIECLVKWMLHSLSEPVGFEADTIFSCLQSLRLVHHAWLR--------------PLE ERLLNRA------RGLGEAGSTASTSSQRKKFVQFFKRNVRSSSSLDSTPHPPLAFGESI LLTGVLSSGDKAFTESSTEVESVDESLLTVPE-----------IVASSDQLVPSLSVLTA VVKSAVLCSDLFTTREQFLWLVGCLQAVYQNLPRIEEGFEAPIYIWLTTGLARCTAVLEA TMLPGTEFGAIPPTASSTEAEEGTDGAATAAPQQHHSAPILLTA-NLQAAVSVATAAMGS TAAVPLQDAGLRAAMDLLQAALLLRATRHPALQQPTLLANPPTGSLLLNSLLIQVCLYLD SRLDNLFESEATLEKRWSTTKDSGFASLRIAGSGGSSGVAKITAGLVRTASTSGRGVNSA LNRAADIPFKPRPPTEWAAECTASHQCTVLATAFYIVEQFSPLVTNESTALSRLIPRLIN HLVRLANAMLRDTSPVFTPPMRLAEVFKNHFADTQATLVCADSVVVAWTRGMQRLLLSG- -----------------------------TLRREECEMLAKQAAERLSCANSMRLRLLAL SLLTTNLYV---------------------------LNADFLLRASPDRSVSANGDGGIK SSLDQPSTDVLLS---TSTEYLT-----SLWQCLRGLGSPTNRPPPIGSHTSPLEARCIS LSLSSFLEDLGRCLLAAASSPSPSFSTILGGLVNKAVAEVART-DQAYVRLATAVLRAAV VTVCGVQRGAKVARELVLLTLPSILHQTSPR----ALRCH------SYWVAAVCTLLLEC GTEL-------------------------------------------------------- ---NCETIHSILAISLAHLPSPEWFQWEERDEEKQCLDLLRAASFLLPPSSSSSTEDGGF RDHFLDILRTAAAAPNSLEPCATADGLAGICEAMKKI Equus_caballus -----MATLEK------------------------------------------------- ---------------------------------LMKAFESLKSF---------QQQQQQ- -------------PPPPPQPPQPPPQAQPPP-PQQQ-PPPPPPPPPPGPAAAEEPLHRPK KELSATKKDRVNH-CLTICENIVAQSLRNSPE-FQKLLGIAMELFLLCSDDAESDVRMVA DECLNKVIKA-----LMDSNLPRLQLELYKEIKKNGAPRSLRAALWRFAELAHLVRPQKC -RPYLVNLLPCLTRTSKRPEESV-QETLATAIPKIMASFGNFANDNE-IKVLLKAFIANL KSSSPTIRRTAAGSAVSICQHSRRT-QYFYTWLLNVLLGLLVPVEDE-HSTLLILGVLLT LRYLVPLLQQQV-KDTSLKGSFG----------VTRKEMEVSP-STEQLVQVYELTLRYT QHQ---DHNVVTGALELLQQLFRTPPP-----------ELLQALTTAGGLGR-------- -------------LAAAKDEPSCRSRSGSIVELIAGGGSSCSPVLSRKQKGKVLLGEAAA LEEDSESRSDSSSPAFAASVKGEIGGELAA-SSG----VSTPGS-ASSAADSAGHDIITE QPR-SQHTLQP-DSVDLTGCD-----------LTSAATDGDEEDILSHSSSQISAVPSDP AMDLNDG-TQ--------------ASSPISDSSQTTTEGPDSAVTPSDSSEI-------- -------------------------------------------------------VLDGP DGQYSGMQIGQPRDEG-EE-AAGLL----------------------------------- --PDEDVDAFTDSAVALQQAHLLERL-------------------GHSRQPSDSSIDKFV SRDEATEPGDQENKPCRIKGDI----GRSADD---DSAPLIHCV---------------- -------RLLSASF-LLTGEKNALVPDRDVRVSVKALALSCVGA-AVALHPESFFSKLYK VP---------------------------------------------------------- ------------------------------------------------------------ -----------------------------LETT-EYPEEQ-----YVSDV---LNYIDHG DPQVRGATAILCGTLVYSI----------------------------------------- --------------------------------------------LSRSRFHVGDWVATVR TLTGNT-F---SLVDCIPLLQKTLKDE-SSVTCKLACTAVRHCVMSLC------------ -SSSYSEFGLQ--------------------------------------------LITDV LTLRNSSYWLVRTELLETLAEIDFRLVSFLEAK----AENIHRGAHHYTG---------- -----------RLKLQERVLNNVVIYLLGDEDPRVRHVAAASLMRLVPK----------- --------------LF--------------YKCDQG---------QADPVVAVARDQSSV Y-----LKLLMHETQPPSHFSVSTI-TRIYRGYNLLPSITDV-TMEN-NLSRVIAAVSHE LITSTTRALTFGCCEALCLLSTAFPVCVWSLGWHC-G----------------------- VPPLSAS----------DEARKSCTV------GMATMILTL--LSSA-------WFPLDL SAHQDA----LILAGNLLAASAPKSLR--SSWTSEEEANPAAT-------KQEEIWPALG DRTLVPMVEQLFSHLLKVINICAHVLDDV-APGPAI--------------KAALPSLTNP P----SLSPIR-------RKGKEKEPGEQASVPLSPK----K---GNEASPASRQSDTSG PVPA--NKSSSLGSFYHLPSYLKLHDVLKATHANYKVTLDLQNSTEKFGGFLRSALDVLS QILE--LATLQDIGKCVEEILGYLKSCFSREPMMATVCVQQLLKTLFGTNLASQFDGLSS N--PS---KSQGRAQRLGSSS--VRP-------GLYHYCFMAPYTHFTQALADASLRNMV -QAEQDHDTSGWFDVLQKVSTQLKTNLTSVTKN-RADKNAIHNHIRLFEPLVIKALKQYT TTTSVQL-QKQVLDLLAQLVQLRVNYCLLDSDQVFIGFVLKQFEYIEVGQF--------- -RESEAIIPNIFFFLVLLSYER--Y-----HSKQIIGIPKIIQLCDGIMASGRKAVTHAI PALQPIVHDLFVL-------------------------------RG--TNKADAG----- ------------------KELETQKEVVVSMLL-RLIQ---YHQVLEMFILVLQQCHKEN -----------EDKWKR---------LSRQIADIILP----------------MLAKQQM HIDSHEALGVLNTLFEILAPSSL---RPVDMLLRSMF----------------------V TPDT----MASVSTVQLWISGILAILRVLISQSTEDIVLSRIQ----------ELSFSPY LISCPII-NRLRDGDSN-STPE--------EQGEGRQVKNLPEETFSRFLLQLVGILLED IV--TKQLKVEMSEQQHT-FYCQELGTLLMCLIHIFKSGMFRRITAAASRLFTAD---GA DSS-FYGLESLNAR---------VRSMVPTHPALVLLWC-----------------QILL LVSHTDYR-WWAEVQQTPKRRSLSSTKSLCPQMSGEEEDSDLAAKLGM---CNREIVRRG ALILFCDYVCQNLHDS------EHLAWLLVNHVQDLIGLSH------EPPVQDFISAVHR NSAAS----GLFIQAIQ-----SRCENLSTPTTLKKTL-QCLEGIHLSQS---GAVLMLY VD-KLLCTPLRVLAR-------MVDTLACRRVEMLLAANLQSNMAQLPVEELNRIQEYLQ NSGLAQRH---QRLYSLLDRLRLATAPGSCGPS-------------PPVTSHPLDGDGPL ALETVNPDKDWYIRLVKSQ----CWTRSDSAL-------LEGAELVNRLPPGD-MSAFMM NS--EFNLSLLAPCL-GLGMREISGGQK----------------------------SPL- ----FEAARVVTLDRV----TSMVQQLPAVH---------QVFQPFLPVEPST------- ------------YWGKVNDLFGDAVLYRSLTTLARALAQYLLVFSKLPSHLHLPPEKEKD TVKFVVMTLEALSWHLMHEQIPLSLDLQAGLDCCCLALQ-LPGLW--------------- -------------------SVLSSPEMVTHACSLIHCV---------------RFLLEAI VVQPG------------------DQLLSPERRTNTPKAAR--EDEVDSNTLNP-KYITAA ---CGMVAEMVE-----------SLPSVLALGHKRN------------------------ ---------------------SSTPAFLTS--VLKNIIISLARLPLVNSYTRVPPLVW-- --------KLGWAPKPGGDFGTA-------------FPEIPVEFLQEKEVFKEFIYRINA LGWTSRTQFEETWATLLGVLVTQP--------LVMEQEES----PPEEDTERTQINVLAV QAITSLVLSAMTVPVAGNPAVSCLEQQPRNK-PLKALDTRFGRKLSIIRGIVEQEIQAMV S--------KRENIATHHLYQAWDPVP-SLSPAT-TGALISH---------DKLLLQ--- --INPERELGNMSYKLGQVS----------------IHSVWLG----------NSITPLR EEEWDEE--------------------------EEEEADVPAPSSAPTSPVNSRKHR--- --AGV-------------DIHSCSQFLLELYSRWI--------LPSSSA-RRTPIILISE VVRSLLVVSDLFTERSQFEMMYLTLTELRRVHPSEDE----ILVQYLVPATCKAAAVLGM DK-------AVAEPVSR-----------------------LLES-TLRSSH--------- ---LPSKIGALHGVLYVLECDLLDDTAKQ--------LIPVISDYLLSNLKGVAHCVNI- ------------------------------------------------------------ -------------------HSQ-QHVLVMCATAFYLIENYPLDVG----------PEFSA SIIQMCGVMLSGSE-ESTPSI----IYH------------------CVLRGLERLLLSE- -----------------------------QLSRLDAESLVKLSVDRVNVHS-PHRAMAAL GLMLTCMYT-------------------------------------GKEKISP-GRTSDP SPAA-PDSESVI----VAMERVS-----VLFDRIR--------------KGFPCEARVVA RILPQFLDDF---------FPPQD-------VMNKVIGEFLSN-QQPYPQFMATVVYKVF QTLHSTGQSSMV-RDWVMLSLSNFTQRAPVAMAVWSLSCFFVSASTSPWVSAVLPHVIS- ------------------------------------------------------------ ---RMGKLE-QVDVNLFCLVATDFYRHQIEEE------LDRRAFQSVFEVVAA---PGNP YHQLLTCLRNVHKVSTC-------------------- Exaiptasia_pallida ---MSLAAADK------------------------------------------------- ---------------------------------LLKIFEALKNY---------------R DGI---------------------------------------------PVVDSNPLAK-K KEVLLSKKDRFLH-IGTIPDLVCSTQIKGLQE-FPKLLAIAVDSLLASCNDDESDVRLVA GEALNKLLKD-----LIDSNLSRLLVELYKEIKKNDAARSLKVALTRFADIAHLIRPQKC -RPFVANLLPCLGRICTRTEDQI-QEALGIAIQKIFPVLGSFTSDVE-VKQLMKAFIPNL KSNQATARRTASSCLAIICQHSRKP-TMFYEWLMNILLGMVLPLQDS-KPSHVYLGVLNC LRQLIPHLEDSFSKDDSLKGSFGSY?SLSVNGSIGQKEVNL-----KQLLQIYEVIMQCT RHS---DHNVINAALETLHQLLRTPPT-----------PLLTVLLSKDGITP-------- -------------S----------------------------------------IKPDTV AGDDLESTSE----------RDSAVGDLDN--------LSTP---------PQDVDSVSD ITSTSDFSSRD-D?VS----------------VTTTLSTADSTDELTK---QISTLTTNQ SPDIKDS-T---------------TDLEMDESESEDTFGSKIL----------------- -------------------------------------------------------NLSGP RPSRSLSDPGVLPDEEDNNQSVGAS----------------------------------- --HNDDSHL---------ETEIPDNP-------------------IHESDRLNDDLGELS QVSESLRTESVNTQEVRVLVES----SFEIDAVACEGVPMVHIV---------------- -------RVMS-SF-LLSGRPGEVL?DSNVRVSVKSLALSCIAQ-AVRLHPESFLVGI-- LP---------------------------------------------------------- ------------------------------------------------------------ -----------------------------NSTT----KDQ-----LIRDI---LLFNAHP DPQLRGGLASVLSHLIAAG----------------------------------------- --------------------------------------------LKKGRLNFNQWSETCC SEHNTAVL---SVERVVSVLGGILQDD-SPVSVRQACSALKGCFHVLC------------ -ASEHCHLVQD--------------------------------------------LIDVI IQLRKNTYWLVKVEVLELVEAMDFKLIAYLESNKSFHSKEITEKCLNYTS---------- --------------IQDTVLYDVVFAMLSDDDGRVRHAAANCCVKLVPK----------- --------------LL--------------MTMGNM---------KQQ---AISRTVCNR L-----DELNISKDHQQNS--------------NILQ-----------NLSKLVSMATEM LNHTTSKFQMVGCIHLLHVLAQSFPVASYPGAWGC-------TVAIHCSSPASPHFSGKG TPPRPGS------------PNMCCRG------GGGALSFAVSSVTTS-------WIAYDL VAHQNL----LQLAGQLLFGIAASGIQ--LSVKMNQHSEETSS-------STHEAWNVFS DISVAPIAEKLIVHLLRVLNIFSHLIDGIMTPGAHSFKINFPGQNKDKDKTAHSPSSTSS PQSTSSPTPIQHVSAVPKRLLKSKRTMSEADLASADK----S---PSKSGGGGQGTDSEP AHPHTPTPKSTSGTFHNLPHYMKLFDVMKGAFCNYQVSL---APQDKFVSFLQNTLDVLS HFME--ILSFTDINKHFEEILGYLQVCVKVEPCKTLLSVQQLLRVMFGVNAVSQADLVQS AVFPSCLERTLITLPTIGSSSDDDNS-------G?YKELFEFPQMLYRQSIEKVILKDEE GESSLKRGIGSLFKKIRKRTGSLIRPSVKIDKQ-----SPIHSYIRLFEPLVIRALKEFT ITTSISL-QQQVLSLLAQLIKLRVNYALLDADQVFITYIQKQFEFVDAGQI--------- -KDCDVLLPFVFQFLVLLSYDC--FQPKFNQAKAIVGMPKVIQLCDGLMASGQSAKTHAI PALQPIVHDLFML-------------------------------RT--LGKADTA----- ------------------KEVETQREVVVSMLL-RFVQ---YSEVLEMLTIVLNCYQRED -----------DDKWKK---------M--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---CDVL-QRLEDDT---ICEQ--------DLKMQEQQAETPEKIFSMFLLQAMFITVQR IV--MLSNAADINGLESSIFLHKQFCRLAVSVNHMFKSENYSRVTMATSCLLNNK----- --PLHQYIVKINAS---------LANIIPTHPLIVLHWA-----------------DILR CLSYDNSA-YWYNLIQTSL-----------PAHQDAKEAHDLIQP------INREITKQA AILLYCDLLVAKETDQ-PGSSLTEVSVLLQSYLEDLIELDH------ETPVAKLLSILHR SEDGSRTLLETFIASYT-----LQSKKQEREITFTRHLVSCLSNVHSSQT---CLLLKIL AE-FFFDSHCRSIT?-------HVEGIICKRLDVEISR-LKDPNNETSAEELTAVCNLMA SKKHIQRN---PRLYSLVHHILQSSKPDI?CSA-------------QLVSSM-------- ---TTTIDQEWYSRLVSHC----CFASGAQDSSLKPRNSQETIHLLSALSFTA-VCNIMS DQ--AFDISLLEDCI-LHGVERTIQFTCRRLSIEGNVS------------------KPYE NTEHFESTGVDHL-LL----AAKLTMFRHMY---------?VVNDVMTTVPCEAQDEGNT STR?VINKD--KFMAFYKDKE------HCILDLARAIVSYCTVVVSLPRQCNLSQEEINC LCRFIFLPLTMLYNKFVAGELPSTFELKIVLNCLGKLLM-MDYT---------------- -------------------QSVNNVEYVTLICQAINQV---------------YTLIKAV SLNGC------------------EKLVHESNENSSQQASE-REDEF--------QSITVA ---CDQISDLIS-----------YTYTYLRPGSHSC------------------------ ---------------------SVLPQFLYE--PFRLTFLGLARRPLVNSYARTPPIVW-- --------KLGWMPTPEGPLKTE-------------LPPLPIEILKEKDVLNEFVMRVNI LGWINRQQFEETWAALLGVLSSPP--------LPENV-------TPEEDMEASHSCCLAV RCIASLLLQTTLYPYPGNCSASGYLHSPRHR-DLPFLGSRAGKKLSVVRGLVEEEFVNTC CIGAGRSYLTREDI-RHEQSASFRRSN-SFITSHGNTSTWTS---------NKLIFDNPL YGLNIDRILGFHEYTFGQLS----------------I----------------NGLHSQA QAQLQEY--------------------------PDSEDDAAVVISMPRMPKPEK------ ----L-------------DIRSCLQFLLELFEQWM--------SPYVQP--KTPLMLLSE ATKALVVFSDLFIDGHHFEWVLNTLLDLYQNHPTEDD----LLTQYSLPVICKALAFLKM EG-------QTAEKVCK-----------------------IIET-SLKSPH--------- ---IPLQMSGLYGAMYILESH-VPSVAAI--------LIPTLTEHLSKRLNSLQNAV-M- ------------------------------------------------------------ -------------------FAQ-QHLLVMWSAVFYLIEHYNDEISD---------ADFKP NVLKVAVRLASSNE-ESTPLA----VYH------------------AIMRGLERLVVSF- -----------------------------ALSSTESDSLVKLSADRLSMQN-PQRSISAL GLLITCMYT-------------------------------------GKLTQESHGIYPQP DTTEFP?EDRLL----IAMERVT-----VLFDRIR--------------KGFPSEAQIVS RVLPRLLLDF---------FPSQE-------IMNKVIGEFLSS-QQPHPELMAEVLFKVF EGLHSQGQQSEV-SDWVVLSLGSFVQRTPLSMAVWSLSCFFISASTSRWIRALFPHILG- ------------------------------------------------------------ ---RMNKLE-EIDKKYFCAFAVDFYRNQNLDD------SQKKNFLTTFKRVAT---PGTP YYLLTAACEK--------------------------- Felis_silvestris_catus -----MATLEK------------------------------------------------- ---------------------------------LMKAFESLKSF---------QQQQQQQ QQQQQQQPQPPPPPPQPPQPPQPLPQAQPPL-PQPQPPPPPPPPPPPGPAVAEEPLHRPK KELSATKKDRVNH-CLTICENIVAQSLRNSPE-FQKLLGIAMELFLLCSDDAESDVRMVA DECLNRVIKA-----LMDSNLPRLQLELYKEIKKNGAPRSLRAALWRFAELAHLVRPQKC -RPYLVNLLPCLTRISKRPEESV-QETLAAAVPKIMASFGNFANDNE-IKVLLKAFIANL KSSSPTIRRTAAGSAVTICQHSRRT-QYFYSWLLNVLLGLLVPVEDE-HSTLLILGVLLT LRYLVPLLQQQV-KDTSLKGSFG----------VTRKEMEVCP-STEQLIQVYELTLHYT QHQ---DHNAVTGALELLQQLFRTPPP-----------ELLQALTAPGG-GQ-------- -------------RSGVQYGPGGRSRSGSIAELLAGGGSSCSPVLSRKQKGKVLFGDAAA LEDDSESRSEGSSPAFAASVKGEIGGELAA-SSG----VSTPGS-AGSTADSVGHDIITE QPR-SQHTLQP-DSVDLTGSD-----------LASAATDGDEEDILSHSSSQISAVPSDP AMDLNDG-TQ--------------ASSPVSDSSQTTTEGPDSAVTPSDSSEI-------- -------------------------------------------------------VLDGA DSQYSGMQIGQPQDED-EE-AAGIL----------------------------------- --PEEDVDAFRNSAAALQQAHLLKSM-------------------GHSRRPSDSSVDTFV SRDEAAEAGDQENKPCRIKGDI----GQSTDD---DSVPLVHCV---------------- -------RLLSASF-LLTGEKNVLVPDRDVRVSVKALALSCVGA-AVALHPESFFSKLYK VP---------------------------------------------------------- ------------------------------------------------------------ -----------------------------LDSV-EYPEEP-----YVSDI---LNYIDHG DPQVRGATAVLCGTLISST----------------------------------------- --------------------------------------------LSRSRFQVGDWMGTVR ALTGNT-F---SLEDCIPLLRKTLKDE-SSVTCKLACTAVRHCVMSLC------------ -SSSSSELGLQ--------------------------------------------LITDV LSLRDSSYWLVRTELLETLAEIDFRLVSFLEAK----AENLHRGAHHYTG---------- -----------LLKLQDRVLHDVVIYLLGDEDPRVRHVAAAALMRLVPK----------- --------------LF--------------YKCDQG---------QADPVVAVARDQSSV Y-----LKLLMHETQPPSHFSVSTI-TRIYRGYNLLPSMTDV-TVEN-NLSRVIAAVSHE LVTSTTRALTFGCCEALCLLSTAFPVCVWSLGWHC-G----------------------- APPLSVS----------GESRKSCTV------GMATVILTL--LSSA-------WFPLDL AAHQDA----LVLAGNLLAASAPRSLR--SSWTSEEEANPAAA-------KQEEVWPALG DRTLVPMVEQLFSHLLKVINICAHVLDDV-APGPAI--------------KAALPSLTNP P----SLSPIR-------RKGKEKEPGEQASAPLSPK----K---GSEASPASRQSDASG PVTA--NKSSSLGSFYHLPSYLKLHDVLKATHANYKVTLDLQNSAEKFGGFLRSALDVLS QILE--LATLQDIGKCVEEILGYLKSCFSREPMMATVCVQQLLKTLFGTNLASQFDGLSS N--PS---KSQGRAQRLGSSS--VRP-------GLYHYCFMAPYTHFTQALADASLRNMV -QAEQDHDASGWFDVLQKVSTQLKTNLTSTTKN-RADKNAIHNHIRLFEPLVIKALKQYT TTTSVQL-QRQVLDLLAQLVQLRVNYCLLDSDQVFIGFVLKQFEYIEVGQF--------- -RESEAIIPNIFFFLVLLSYER--Y-----HSKQIIGIPKIIQLCDGIMASGRKAVTHAI PALQPIVHDLFVL-------------------------------RG--ANKADAG----- ------------------KELETQKEVVVSMLL-RLIQ---YHQVLEMFILVLQQCHKES -----------EDKWKR---------LSRQIADVILP----------------MLAKQQM HIDSHEALGVLNTLFEILAPSSL---RPVDMLLRSMF----------------------V TPDT----MAPVSTVQLWISGILAILRVLISQSTEDIVLSRIQ----------ELSFSPY LISCPVI-NRLREGDST-STPE--------EHGEGRQMKSLPEETFSRFLLQLVGILLED IV--TKQLKVEMSEQQHT-FYCQELGTLLMCLIHIFKSGMFRRITAAASRLLTVD---SS DSS-FYGLDRLNAQ---------VRAMVPTHPALVLLWC-----------------QILL LVSHTDHR-WWAEVQQTPRRRSLSSTKSLSPQMSGEEGDSDAASKPGM---CNREIVRRG ALILFCDYVCQNLHDS------EHLTWLIVNHIQDLINLSH------EPPVQDFISAVHR NSAAS----GLFIQAIQ-----SRCENLSAPTTLKKTL-QCLEGIHLSQS---GAVLTLY VD-KLLCTPFRVLAR-------MVDTLACRRVEMLLAANLQSSMAQLPVEELTRIQEYLQ SSGLAQRH---QRLYSLLDRLRLATAPGSRGPS-------------PPITSHPLDGDGPL ALETVIPDKDWYLRLVKSQ----CWTRSDSAL-------LEGAELVNRIPPSD-MSTFMM NS--EFNLSLLAPCL-GLGMREVSGGQR----------------------------SPL- ----FEAARLATLDRV----TGLVQQLPAAH---------HVFQPFLPTEPTA------- ------------YWNKLNDLFGDAVLYRSLTTLARALAQYLLVFSKLPGHLHLPPEKERD TVKFVVMTLEALSWHLIHEQIPLSLDLQAGLDCCCLALQ-LPSVW--------------- -------------------SALSSPEMVTHACSLIHCV---------------RFILEAI VVQPG------------------DQLLSPDRRMNTPKAAR--EDEVDSNTQNP-AYITAA ---CGMVAEMVE-----------ALPSVLALGHKRN------------------------ ---------------------SSTPAFLTS--VLRNIIISLARLPLVNSYTRVPPLVW-- --------KLGWSPKPGGDFGTA-------------FPEIPVEFLQEKEVFKEFIYRINT LGWTSRTQFEETWATLLGVLVTQP--------LVMEQEES----PPEEDTERTQINVLAV QAITSLVLSAMTVPVAGNPAVSCLEQQPRNK-PLKALDTRFGRKLSIIRGIVEQEIQAMV S--------KRENVATHHLYQAWDPVP-SLSPAT-TGALIGH---------DKLLLQ--- --INPERELGNMSYKLGQVS----------------IHSVWLG----------NSITPLR EEEWEEE--------------------------EEEEADVPTSASPPTSPVNSRKHR--- --AGV-------------DIHSCSQFLLELYSRWI--------LPSGSA-RRTPIILISE VVRSLLVVSDLFTERTQFEMMYLTLTELRRAHPAEDE----ILIQYLVPATCKAAAVLGM DK-------AVAEPVSR-----------------------LLES-TLRSSH--------- ---LPSRVGALHGALYVLECDLLDETAKQ--------LVPVISDYLLSNLKGAAHCVNV- ------------------------------------------------------------ -------------------HSQ-QHVLVMCATAFYLIENYPLDVG----------PEFSA SVIQMCGVMLSGSE-ESTPSI----IYH------------------CVLRGLERLLLSE- -----------------------------QLCRLDAESLVKLSVDRVNVHS-PHRAMAAL GLMLTCMYT-------------------------------------GKEKISP-GRTSDP SPAA-PDSESVI----VAMERVS-----VLFDRVR--------------KGFPCEARVVA RILPQFLDDF---------FPPQD-------VMNKVIGEFLSN-QQPYPQFMATVVYKVF QTLHSSGQSSMV-RDWVMLSLSNFTQRSPVAMAVWSLSCFFVSASTSPWVSAVLPHVIS- ------------------------------------------------------------ ---RMGKLE-RVDVNLFCLVATDFYRHQIEEE------LDRRAFQSVFEVVAA---PGNP YHRLLTCLRNVHKVASC-------------------- Gallus_gallus -----MATMEK------------------------------------------------- ---------------------------------LMKAFESLRSF---------------Q QQQVP-------------------------------------------AAIPEEPTQRPK KELLTTKKDRVNH-CLTICENIVAQSLRNSPE-FQKLLGIAMELFLLCSEDVESDVRMVA DECLNKVIKA-----LMDSNLPRLQLELYKEIKKNGASRSLRAALWRFAELAHLVRPQKC -RPYLVNLLPCLTRISKRPEESV-QETLAAAIPKIMAAFGNFANDNE-IKVLLKAFIANL KSSSPTIRRTAAGSAVSICQHSRRT-QYFYAWLLNVLLGLLVPVEDD-HPTLLILGVLLT LRYLIPLLQQQV-KDTSLKGSFG----------VTRKETEISP-SPEQLIQVYELTLHYT QHQ---DHNVVTGALELLQQLFRTPPP-----------ELLHALTSLGGIAQ-------- -------------VSVSKDESAIRSRSGSIVELIAGGGSSCSPVLARKHKGKILLGEEEG LEDDPETRSDVSAASFAASVKGEITSELAS-SSG----VSTAGSVGSSAADPTGHDIITE QPR-SQHTLQS-DSVDLSSCD-----------LTSTATEGEDDDVLSRSSSQISAVQSDP TMDLNDG-TQ--------------ASSPISDSSQTTTEGPDSAVTPSDSSEI-------- -------------------------------------------------------VLEGA EGQYSGMQIGQLQDEE-DE-AANIL----------------------------------- --QDDSSESFR-SSIALQQPHLLKTM-------------------SHSRQPSDSSVDRFP SKEDAVEPIDHENKPSRVKGDI----GHYTDG---NSAPLVHCV---------------- -------RLLSASF-LLTGEKGALVPDRDVRVSVKALAVSCVGA-AVALHPESFFSKLYK MP---------------------------------------------------------- ------------------------------------------------------------ -----------------------------LEAMGEDYEEQ-----YVSDI---LNYIDHG DPQIRGATAILCGTIINSI----------------------------------------- --------------------------------------------LLKSRFDVEKWLVNVR SSTGNL-F---SLVDCIPLLQKTLKDE-SSVTCKLACTAVRHCIMSLC------------ -SSSYSELGLQ--------------------------------------------LIVDL LTLKNSSYWLVRTELLETLAEVDFRLVSFLEGK----TDSLHRGVHHYTG---------- -----------LLKIQERVLNDVVICLLGDEDPRVRHVAAASLMRLVPK----------- --------------LF--------------YNCDQG---------QADPVVAVARDQSGV Y-----LKLLMHETQPPSHFAVSTI-TRTYRGYNMLQNPTDV-TMEN-NLSRVVAAISHA LTISTTRSLTFGCCEALCLLSTTFPVCTWTVGWHC-G----------------------- VSQPSPS----------DDAQKGCTI------GMAGMVLSL--LSST-------WFPLDL SAHQDA----LILTGNLLAASAPKCLK--NPWSAEEDSNQVAA-------KQEEPWPALA DRTLVTLVEQLFSHLLKVINICAHVMDDV-APGPAV--------------KAALPSLTNP P----SLSPIR-------RKGKEREPVEQTSVPMSPK----K---GGETSPATRQTDASG PAPT--SKSSSVGSFYHLPSYLKLYDVLKATHANYKVTLDLQNSNEKFGCFLRSALDVLS QILE--LATLQDIGKCVEEILGYLKSCFNREPTMATVCVQQLLKTLFGTNLASQYDGLSS N--TS---KAQGKAQRLGSSN--LRP-------GLYHYCFMAPYTHFTQALADASLRNMV -QAEQEHDASGWFDVLQKVSTQLKTNITSAAKH-RADKNAIHNHIRLFEPLVIKALKQYT TTTSVQL-QRQVLDLLAQLVQLRVNYCLLDSDQVFIGFVLKQFEYIEVGQF--------- -RESEAIIPNIFFFLVLLSYER--Y-----HSKQIIGIPKIIQLCDGIMASGRKAVTHAI PALQPIVHDLFVL-------------------------------RG--TNKADAG----- ------------------KELETQKEVVVSMLL-RLIQ---YHQVLEMFILVLQQCHKEN -----------EDKWKR---------LSRQIADIILP----------------MLAKQQM HIDSHDALGVLNTLFEILAPSSL---RPVDMLLRSMF----------------------V TPKT----MASVSTVQLWISGILAILRVLISQSTEDIVLSRVQ----------ELSFSPY LISRQAI-NRLRHGENNVSAQE--------DHSEVKQTKYLPEETFSRFLLQLVGILLED IV--TKQVKVDMNEQQHT-FYCQELGTLLMCLIHIFKSGMFRRITAAATRLFTGD---GS DGS-FYTLESLSDL---------VQSMVPTHPSLVLLWC-----------------QILL LVNYTNYN-WWSEVHQTPKRHSLSTTKLLSPQISGDSDESDSESKRGM---CNREIVRRG ALILFCDYVCQNLHDS------EHLTWLIVNHVQDLINLSH------EPPVQDFISAVHR NSAAS----GLFIQAIQ-----SRCENLAAPTTLKKTL-QCLEGIHLSQS---GAVLTLY VD-KLLCTPFRVLAR-------MVDTLACRRVEMLLAATLQNSITQLPVEELDRIQEYLQ NSGLATRH---QRLYSLLDRFRLMVAPDTTSPS-------------PLVTSHPLDGEDQP GLENVILDKDWYMSLVRSQ----CCIKSDSAL-------LEGAELLNRIPQPD-LNSFMN SK--EFNLSLLAPCL-SLGMNEISRDQK----------------------------SSL- ----FEAARRVTLDHL----SATVLNLPASH---------QVFQPLLPTEPSA------- ------------YWKKLNDIFGDEVMYQSVMTLCRALAQYLLLLSKLPTSLRVPPDKEDD ILKFVVMSIEALSWHLIHDRLPISIDLQAALDCCCLTLQ-QPSLW--------------- -------------------NLLASAANVTYACSLINCI---------------KFIIEAV AVEPG------------------NQLLSPERKKNASKGLS--EDEVDSNMHKM-KHITAA ---CEMVAEMVE-----------CLQTVLALGHHRN------------------------ ---------------------SSIPAFLTP--VLKNIIISLARLPLVNSYTRVPPLVW-- --------KLGWSPKPAGDFGTV-------------FPEIPVEFLQEKEIFKEFIYRINT LGWISRTQFEETWATLLGVLVTQP--------IVMDQEEN----QQEEDTERTQINVLAV QAITSLVLSAMTIPVAGNPAVSCLEQQPRNK-ALKALDTRFGRKLSVIRGIVEQEIQAMV S--------KRDNIATHHLYQAWDPVP-SLSPVS-TGALISH---------EKLLLQ--- --INTEREIGDMDYKLGQVS----------------IHSIWLG----------NNITPLR EEEWGED--------------------------EEDENDVPVPSSPPTSPINTRKHR--- --AGV-------------DIHSCSQFLLELYSQWI--------LPSSPN-KRTPVILISE VVRSLLAVSDLFTERNQFEMMYTTLTELRKVHPSEDE----ILIQYLIPATCKAAAVLGM DK-------AVAEPVSR-----------------------LLES-TLRSTH--------- ---MPSRIGALHGILYILECDLLDETAKQ--------LIPIISEYLLSNLRAVAHCVTV- ------------------------------------------------------------ -------------------HNQ-QHILVMCAAAFYLIENYPLDVG----------PEFSA GIIQMCGVMVSGSD-ESTPSI----IYH------------------CVLRGLERLLLSE- -----------------------------QLSRLDSESLVKLSVDRVNVQS-PHRAMAAL GLMLTCMYT-------------------------------------GKEKVSP-SRSTDA NPAA-PDSESVI----VAMERVS-----VLFDRIR--------------KGFPFEARVVA RILPQFLDDF---------FPPQD-------VMNKVIGEFLSN-QQPYPQFMATVVYKVF QTLHTTGQSSMV-RDWVMLSLSNFTQRTPVAMAMWSLSCFFVSASTSQWISAILPHIIS- ------------------------------------------------------------ ---RMGKLE-QVDVNIFCLVAMDFYRHQIDEE------LDRRAFQSVFEVVAS---PGTP YHRLLTCLQNVHKVTAC-------------------- Gorilla_gorilla_gorilla ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------MELFLLCSDDAESDVRMVA DECLNKVIKA-----LMDSNLPRLQLELYKEIKKNGAPRSLRAALWRFAELAHLVRPQKC -RPYLVNLLPCLTRTSKRPEESV-QETLAAAVPKIMASFGNFANDNE-IKVLLKAFIANL KSSSPTIRRTAAGSAVSICQHSRRT-QYFYSWLLNVLLGLLVPVEDE-HSTLLILGVLLT LRYLVPLLQQQV-KDTSLKGSFG----------VTRKEMEVSP-SAEQLVQVYELTLHHT QHQ---DHNVVTGALELLQQLFRTPPP-----------ELLQTLTAVGGIGQ-------- -------------LTAAKEESGGRSRSGSIVELIAGGGSSCSPVLSRKQKGKVLLGEEEA LEDDSESRSDVSSSALTASVKDEISGELAA-SSG----VSTPG--------SAGHDIITE QPR-SQHTLQA-DSVDLASCD-----------LTSSATDGDEEDILSHSSSQVSAVPSDP AMDLNDG-TQ--------------ASSPISDSSQTTTEGPDSAVTPSDSSEI-------- -------------------------------------------------------VLDGT DNQYLGLQIGQPQDED-EE-ATGIL----------------------------------- --PDEASEAFRNSSMALQQAHLLKNM-------------------SHSRQPSDSSVDKFV LRDEATEPGDQENKPCRIKGDI----GQSTDD---DSAPLVHCV---------------- -------RLLSASF-LLTGGKNVLVPDRDVRVSVKALALSCVGA-AVALHPESFFSKLYK VP---------------------------------------------------------- ------------------------------------------------------------ -----------------------------LDTT-EYPEEQ-----YVSDI---LNYIDHG DPQVRGATAILCGTLICSI----------------------------------------- --------------------------------------------LSRSRFHVGDWMGTIR TLTGNT-F---SLADCIPLLRKTLKDE-SSVTCKLACTAVRHCVMSLC------------ -SSSYSELGLQ--------------------------------------------LIIDV LTLRNSSYWLVRTELLETLAEVDFRLVSFLEAK----AENLHRGAHHYTG---------- -----------LLKLQERVLNNVVIHLLGDEDPRVRHVAAASLIRLVPK----------- --------------LF--------------YKCDQG---------QADPVVAVARDQSSV Y-----LKLLMHETQPPSHFSVSTI-TRIYRGYNLLPSITDV-TMEN-NLSRVIAAVSHE LITSTTRALTFGCCEALCLLSTAFPVCIWSLGWHC-G----------------------- VPPLSAS----------DESRKSCTV------GMATMILTL--LSSA-------WFPLDL SAHQDA----LILAGNLLAASAPKSLR--SSWASEEEANPAAT-------KQEEVWPALG DRALVPMVEQLFSHLLKVINICAHVLDDV-APGPAI--------------KAALPSLTNP P----SLSPIR-------RKGKEKEPGEQASVPLSPK----K---GSEASAASRQSDTSG PVTT--SKSSSLGSFYHLPSYLKLHDVLKATHANYKVTLDLQNSTEKFGGFLRSALDVLS QILE--LATLQDIGKCVEEILGYLKSCFSREPMMATVCVQQLLKTLFGTNLASQFDGLSS N--PS---KSQGRAQRLGSSS--VRP-------GLYHYCFMAPYTHFTQALADASLRNMV -QAEQEHDTSGWFDVLQKVSTQLKTNLTSVTKN-RADKNAIHNHIRLFEPLVIKALKQYT TTTCVQL-QKQVLDLLAQLVQLRVNYCLLDSDQVFIGFVLKQFEYIEVGQF--------- -RESEAIIPNIFFFLVLLSYER--Y-----HSKQIIGIPKIIQLCDGIMASGRKAVTHAI PALQPIVHDLFVL-------------------------------RG--TNKADAG----- ------------------KELETQKEVVVSMLL-RLIQ---YHQVLEMFILVLQQCHKEN -----------EDKWKR---------LSRQIADIILP----------------MLAKQQM HIDSHEALGVLNTLFEILAPSSL---RPVDMLLRSMF----------------------V TPNT----MASVSTVQLWISGILAILRVLISQSTEDIVLSRIQ----------ELSFSPY LISCTVI-NRLRDGDSN-STLE--------EHSEGKQIKNLPEETFSRFLLQLVGILLED IV--TKQLKVEMSEQQHT-FYCQELGTLLMCLIHIFKSGMFRRITAAATRLFRSD---GC GGS-FYTLDSLNLR---------ARSMITTHPALVLLWC-----------------QILL LVNHTDYR-WWAEVQQTPKRHSLSSTKLLSPQMSGEEEDSDLAAKLGM---CNREIVRRG ALILFCDYVCQNLHDS------EHLTWLIVNHIQDLISLSH------EPPVQDFISAVHR NSAAS----GLFIQAIQ-----SRCENLSTPTTLKKTL-QCLEGIHLSQS---GAVLTLY VD-RLLCTPFRVLAR-------MVDILACRRVEMLLAANLQSSMAQLPVEELNRIQEYLQ SSGLAQRH---QRLYSLLDRFRLSTMQDSLSPS-------------PPVSSHPLDGDGHV SLETVSPDKDWYIHLVKSQ----CWTRSDSAL-------LEGAELVNRIPAED-MSAFMM NS--EFNLSLLAPCL-SLGMSEISGGQK----------------------------SAL- ----FEAAREVTLARV----SGTVQQLPAVH---------HVFQPELPAEPAA------- ------------YLSKLNDLFGDAALYQSLPTLARALAQYLVVVSKLPSHLHLPPEKEKD IVKFVVATLEALSWHLIHEQIPLSLDLQAGLDCCCLALQ-LPGLW--------------- -------------------SVVSSTEFVTHACSLIHCV---------------HFILEAV AVQPG------------------EQLLSPERRTNTPKAIREEEEEVDPNTHNP-KYITAA ---CEMVAEMVE-----------SLQSVLALGHKRN------------------------ ---------------------SGVPAFLTP--VLRNIIISLARLPLVNSYTRVPPLVW-- --------KLGWSPKPGGDFGTA-------------FPEIPVEFLQEKEVFKEFIYRINT LGWTSRTQFEETWATLLGVLVTQP--------LVMEQEES----PPEEDTERTQINVLAV QAITSLVLSAMTVPVAGNPAVSCLEQQPRNK-PLKALDTRFGRKLSIIRGIVEQEIQAMV S--------KRENIATHHLYQAWDPVP-SLSPAT-TGALISH---------EKLLLQ--- --INPERELGSMSYKLGQVS----------------IHSVWLG----------NSITPLR EEEWDEE--------------------------EEEEADAPAPSSPPTSPVNSRKHR--- --AGV-------------DIHSCSQFLLELYSRWI--------LPSSSA-RRTPAILISE VVRSLLVVSDLFTERNQFELMYVTLTELRRVHPSEDE----ILAQYLVPATCKAAAVLGM DK-------AVAEPVSR-----------------------LLES-TLRSSH--------- ---LPSRVGALHGVLYVLECDLLDDTAKQ--------LIPVISDYLLSNLKGIAHCVNI- ------------------------------------------------------------ -------------------HSQ-QHVLVMCATAFYLIENYPLDVG----------PEFSA SIIQMCGVMLSGSE-ESTPSI----IYH------------------CALRGLERLLLSE- -----------------------------QLSRLDAESLVKLSVDRVNVHS-PHRAMAAL GLMLTCMYT-------------------------------------GKEKVSP-GRTSDP NPAA-PDSESVI----VAMERVS-----VLFDRIR--------------KGFPCEARVVA RILPQFLDDF---------FPPQD-------IMNKVIGEFLSN-QQPYPQFMATVVYKVF QTLHSTGQSSMV-RDWVMLSLSNFTQRTPVAMATWSLSCFFVSASTSPWVAAILPHVIS- ------------------------------------------------------------ ---RMGKLE-QVDVNLFCLVATDFYRHQIEEE------LDRRAFQSVLEVVAA---PGSP YHRLLTCLRNVHKVTTC-------------------- Homo_sapiens -----MATLEK------------------------------------------------- ---------------------------------LMKAFESLKSFQQQQQQQQQQQQQQQQ QQQQQQQPPPPPPPPPPPQLPQPPPQAQPLL-PQPQ-PPPPPPPPPPGPAVAEEPLHRPK KELSATKKDRVNH-CLTICENIVAQSVRNSPE-FQKLLGIAMELFLLCSDDAESDVRMVA DECLNKVIKA-----LMDSNLPRLQLELYKEIKKNGAPRSLRAALWRFAELAHLVRPQKC -RPYLVNLLPCLTRTSKRPEESV-QETLAAAVPKIMASFGNFANDNE-IKVLLKAFIANL KSSSPTIRRTAAGSAVSICQHSRRT-QYFYSWLLNVLLGLLVPVEDE-HSTLLILGVLLT LRYLVPLLQQQV-KDTSLKGSFG----------VTRKEMEVSP-SAEQLVQVYELTLHHT QHQ---DHNVVTGALELLQQLFRTPPP-----------ELLQTLTAVGGIGQ-------- -------------LTAAKEESGGRSRSGSIVELIAGGGSSCSPVLSRKQKGKVLLGEEEA LEDDSESRSDVSSSALTASVKDEISGELAA-SSG----VSTPG--------SAGHDIITE QPR-SQHTLQA-DSVDLASCD-----------LTSSATDGDEEDILSHSSSQVSAVPSDP AMDLNDG-TQ--------------ASSPISDSSQTTTEGPDSAVTPSDSSEI-------- -------------------------------------------------------VLDGT DNQYLGLQIGQPQDED-EE-ATGIL----------------------------------- --PDEASEAFRNSSMALQQAHLLKNM-------------------SHCRQPSDSSVDKFV LRDEATEPGDQENKPCRIKGDI----GQSTDD---DSAPLVHCV---------------- -------RLLSASF-LLTGGKNVLVPDRDVRVSVKALALSCVGA-AVALHPESFFSKLYK VP---------------------------------------------------------- ------------------------------------------------------------ -----------------------------LDTT-EYPEEQ-----YVSDI---LNYIDHG DPQVRGATAILCGTLICSI----------------------------------------- --------------------------------------------LSRSRFHVGDWMGTIR TLTGNT-F---SLADCIPLLRKTLKDE-SSVTCKLACTAVRNCVMSLC------------ -SSSYSELGLQ--------------------------------------------LIIDV LTLRNSSYWLVRTELLETLAEIDFRLVSFLEAK----AENLHRGAHHYTG---------- -----------LLKLQERVLNNVVIHLLGDEDPRVRHVAAASLIRLVPK----------- --------------LF--------------YKCDQG---------QADPVVAVARDQSSV Y-----LKLLMHETQPPSHFSVSTI-TRIYRGYNLLPSITDV-TMEN-NLSRVIAAVSHE LITSTTRALTFGCCEALCLLSTAFPVCIWSLGWHC-G----------------------- VPPLSAS----------DESRKSCTV------GMATMILTL--LSSA-------WFPLDL SAHQDA----LILAGNLLAASAPKSLR--SSWASEEEANPAAT-------KQEEVWPALG DRALVPMVEQLFSHLLKVINICAHVLDDV-APGPAI--------------KAALPSLTNP P----SLSPIR-------RKGKEKEPGEQASVPLSPK----K---GSEASAASRQSDTSG PVTT--SKSSSLGSFYHLPSYLKLHDVLKATHANYKVTLDLQNSTEKFGGFLRSALDVLS QILE--LATLQDIGKCVEEILGYLKSCFSREPMMATVCVQQLLKTLFGTNLASQFDGLSS N--PS---KSQGRAQRLGSSS--VRP-------GLYHYCFMAPYTHFTQALADASLRNMV -QAEQENDTSGWFDVLQKVSTQLKTNLTSVTKN-RADKNAIHNHIRLFEPLVIKALKQYT TTTCVQL-QKQVLDLLAQLVQLRVNYCLLDSDQVFIGFVLKQFEYIEVGQF--------- -RESEAIIPNIFFFLVLLSYER--Y-----HSKQIIGIPKIIQLCDGIMASGRKAVTHAI PALQPIVHDLFVL-------------------------------RG--TNKADAG----- ------------------KELETQKEVVVSMLL-RLIQ---YHQVLEMFILVLQQCHKEN -----------EDKWKR---------LSRQIADIILP----------------MLAKQQM HIDSHEALGVLNTLFEILAPSSL---RPVDMLLRSMF----------------------V TPNT----MASVSTVQLWISGILAILRVLISQSTEDIVLSRIQ----------ELSFSPY LISCTVI-NRLRDGDST-STLE--------EHSEGKQIKNLPEETFSRFLLQLVGILLED IV--TKQLKVEMSEQQHT-FYCQELGTLLMCLIHIFKSGMFRRITAAATRLFRSD---GC GGS-FYTLDSLNLR---------ARSMITTHPALVLLWC-----------------QILL LVNHTDYR-WWAEVQQTPKRHSLSSTKLLSPQMSGEEEDSDLAAKLGM---CNREIVRRG ALILFCDYVCQNLHDS------EHLTWLIVNHIQDLISLSH------EPPVQDFISAVHR NSAAS----GLFIQAIQ-----SRCENLSTPTMLKKTL-QCLEGIHLSQS---GAVLTLY VD-RLLCTPFRVLAR-------MVDILACRRVEMLLAANLQSSMAQLPMEELNRIQEYLQ SSGLAQRH---QRLYSLLDRFRLSTMQDSLSPS-------------PPVSSHPLDGDGHV SLETVSPDKDWYVHLVKSQ----CWTRSDSAL-------LEGAELVNRIPAED-MNAFMM NS--EFNLSLLAPCL-SLGMSEISGGQK----------------------------SAL- ----FEAAREVTLARV----SGTVQQLPAVH---------HVFQPELPAEPAA------- ------------YWSKLNDLFGDAALYQSLPTLARALAQYLVVVSKLPSHLHLPPEKEKD IVKFVVATLEALSWHLIHEQIPLSLDLQAGLDCCCLALQ-LPGLW--------------- -------------------SVVSSTEFVTHACSLIYCV---------------HFILEAV AVQPG------------------EQLLSPERRTNTPKAISEEEEEVDPNTQNP-KYITAA ---CEMVAEMVE-----------SLQSVLALGHKRN------------------------ ---------------------SGVPAFLTP--LLRNIIISLARLPLVNSYTRVPPLVW-- --------KLGWSPKPGGDFGTA-------------FPEIPVEFLQEKEVFKEFIYRINT LGWTSRTQFEETWATLLGVLVTQP--------LVMEQEES----PPEEDTERTQINVLAV QAITSLVLSAMTVPVAGNPAVSCLEQQPRNK-PLKALDTRFGRKLSIIRGIVEQEIQAMV S--------KRENIATHHLYQAWDPVP-SLSPAT-TGALISH---------EKLLLQ--- --INPERELGSMSYKLGQVS----------------IHSVWLG----------NSITPLR EEEWDEE--------------------------EEEEADAPAPSSPPTSPVNSRKHR--- --AGV-------------DIHSCSQFLLELYSRWI--------LPSSSA-RRTPAILISE VVRSLLVVSDLFTERNQFELMYVTLTELRRVHPSEDE----ILAQYLVPATCKAAAVLGM DK-------AVAEPVSR-----------------------LLES-TLRSSH--------- ---LPSRVGALHGVLYVLECDLLDDTAKQ--------LIPVISDYLLSNLKGIAHCVNI- ------------------------------------------------------------ -------------------HSQ-QHVLVMCATAFYLIENYPLDVG----------PEFSA SIIQMCGVMLSGSE-ESTPSI----IYH------------------CALRGLERLLLSE- -----------------------------QLSRLDAESLVKLSVDRVNVHS-PHRAMAAL GLMLTCMYT-------------------------------------GKEKVSP-GRTSDP NPAA-PDSESVI----VAMERVS-----VLFDRIR--------------KGFPCEARVVA RILPQFLDDF---------FPPQD-------IMNKVIGEFLSN-QQPYPQFMATVVYKVF QTLHSTGQSSMV-RDWVMLSLSNFTQRAPVAMATWSLSCFFVSASTSPWVAAILPHVIS- ------------------------------------------------------------ ---RMGKLE-QVDVNLFCLVATDFYRHQIEEE------LDRRAFQSVLEVVAA---PGSP YHRLLTCLRNVHKVTTC-------------------- Hydra_vulgaris -------MADK------------------------------------------------- ---------------------------------IVKAFEALRNH---------------- ------------------------------------YLQEPTHTLTQVQTSESDGAVIKK KDALLSVRERISH-CNTIADFLPLSSVKDISD-FPRLFTLAIELLLICCDDNEADVRLLA GECLNKIMKG-----FLHSNIGRIQVELYKEIKKNGSSRSLRAAMQ-------------- -RPYVANLLPCIVKIAKREDDAI-QETLGVMMSKLCPVIGKFMNEDD-VK---------- ------------------------------------------------------------ ---------------------------------------------------IYEVTMFCT KHG---DHNIVTAALETLNQILLCQAK-----------FLTSILLSPTGIAA-------- -------------T---------------------------------------ITGQLPD LLDESLSSSQMGDS-------------------------------------GLSNDLYSL SSS-TSDIFNS----------------------------KKSDDDIAESSLEPSVNNLWE VPKIDYF-----------------SNIMITDKNDFVSTESISSY---------------- -------------------------------------------------------NLDVP NDFEGGLDLPRTYTQ-----GSMVN----------------------------------- --IESHTDGY---------------V-------------------TDQSFGIDSQDDLSS CTFEDPRQKDLLNKDSFVALQS----LFNFDPVSCTGVPALHCV---------------- -------RVMC-SF-LLQGKPGCVLPDNQTRVSVKALALSCICS-ALKIFPEAFVAKALP DD---------------------------------------------------------- ------------------------------------------------------------ -----------------------------I----DFSNGQ-----LVRDI---MLFSTHD DPHLRGLVAAIVSSFICCT----------------------------------------- --------------------------------------------VKQAGGEFTNWIDKVT TFYETDLL---DLKQVINVLLVILNDE-SATAVKQCCQAISQCIHAIL------------ -ESTCNLLGYE--------------------------------------------LVWKL LDHSSSTYWLVKVEIMEIFQVLNYPLLHILQNS-WVHLKSIPRINVKHAS---------- --------------IQDQVI-DVLLKLLGDEDPRVRSKAASALVNVVPK----------- --------------LY--------------C----------------------------- ----------------PNEINICCL-----PSLSVHVLNNKN-SIHT-NLTYLLRKLMLH QKKFSLKYVQLGCLECFYLLSISYPVSLHPFSWEM--------------------LPGYS VKESQSS----------NNFRKKLDFSEVQKSSLGLLVFTLDQLSSS-------WIGLDL VAHEQA----LKLSVHLLCGASKRYLNDKAQLSKEHNQSNLLD-----TAVGENMWSSLG NAELTSCAQKLFLHLLKLFSILLHVIEQI---NPLILKNKDKVPDSVSSPQQPLTTGVTP T----SNSPRKFSIVKSATKKQEAESEKLKASEKDPNLPNLK---DPNFPNLNHDSKVTS PYTHVFDKNEKLGFFQSSPHFMNIYVMLKGVFKNYQVS-PVSSSLDKFTSFVKSVLETFS MLLE--LATFVELGPYVEEILEYIKTTVLVDEEASFLALQQLLKGLFGTNAANQPETFKL PESTQQLVKYHGDPTYFYEENNFSNS-LEYETEDVFESCFLVPYNHVYESLKRVP----- -QVVENRSRAVSFLKSFKNPFTANRPLDKVSKE---KMSSIQSYIRMFEPLVIRALKSYT TTSSTSL-QCQTIHLIDQLIRLRVNYSLLDSDQVFIGYVLKQFELVEQGQI--------- -RNPELFIPTVFQFLVLLSYEC--FQPKFTQAKAIIGMPRIMRLCDSVMACGQPVHLYAI PALKPIVQDLFGS-------------------------------SS--QVRSDSG----- ------------------KDLDIQREVVVSMLL-RVIH---YPQVLTMLRHVLINSKADD ------------ERWKR---------LSRQIIDTLLP----------------SLAKLEL TVDTLSDLYLLFDLFDSVAPLAL---RPADIILKSMF--------------------TLT TPTT-------CQEEIRMIAAVISLLRTLIMQNSEEIILSHIP----------SFDTSQT LFSGVLDQEKIAGSSIDSDTAA--------------------TNYLAAFLLNILSMAINN VC--QRYGEVTIYNTHVS-LLVQTLRVFLSLLTYIGKSGSFKKLTSVLLSLLVFS---KT PNT-SSLHIQLTMK---------LSGIKSLEPQLFLLWV-----------------YFIH SLGLMNFD-FWMQCMNHTKEKHYCT--------------------------WKYDLIDQA TFLLHCDLMTAKLKDL------------------------------------AYPSFILR NTALS----QCLLSMLS-----DAVSTIMEKHLIMKSLLVLLEHVELGLS---ANVIYFL LS-LLPSIKIYGLAR-------KAETLACRRMEYL--QSLDDQDYKLPIENLEKFSDVAI HN---KRY---PRLCSLIKRVTKQKVS-------------------EKIVSHPLD-LVAV DLKKFSIDENWMVDFVQKL----CFCDPGNEQEA-----VCSIYLLSSLKNQV-ANGILE NQ--KFSVVLLETLLRETSFRDVRKSKK----------------------------SDL- -----ELSYSYEYSQI-------------------------------------------- ----------------------------------------------------LPPENQD- -------------YLFTSAKTSLIKHIKCFLDDLRLFVE-HDSF---------------- -------------------------QYVSYNVNFLK------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------NSLSDKNLLTKYQYL--- -----------------------------------------------------------V RCVLQILY-----P-------SCYFNQP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------SYL------------- ----------TKEDISK-----------------------ILE----------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------LVLVYP------------------- --------------------------YV------------------CMLQ---------- -----------------------------------------VETNKICVTS--------- --IQQCFHS--------------------------------------------------- ------------------------------------------------------------ -------------------FG--------------LVGIFIMT-----------ILYT-- ----------------------------------------YVPIYINPW----------- ------------------------------------------------------------ ----------------------------NKEK---------------------------- ------------------------------------- Mus_musculus -----MATLEK------------------------------------------------- ---------------------------------LMKAFESLKSF------------QQQQ QQQPPPQAPPPPPPPPPPQPPQPPPQGQPP----------PPPPPLPGP--AEEPLHRPK KELSATKKDRVNH-CLTICENIVAQSLRNSPE-FQKLLGIAMELFLLCSDDAESDVRMVA DECLNKVIKA-----LMDSNLPRLQLELYKEIKKNGAPRSLRAALWRFAELAHLVRPQKC -RPYLVNLLPCLTRTSKRPEESV-QETLAAAVPKIMASFGNFANDNE-IKVLLKAFIANL KSSSPTVRRTAAGSAVSICQHSRRT-QYFYNWLLNVLLGLLVPMEEE-HSTLLILGVLLT LRCLVPLLQQQV-KDTSLKGSFG----------VTRKEMEVSP-STEQLVQVYELTLHHT QHQ---DHNVVTGALELLQQLFRTPPP-----------ELLQALTTPGGLGQ-------- -------------LTLVQEEARGRGRSGSIVELLAGGGSSCSPVLSRKQKGKVLLGEEEA LEDDSESRSDVSSSAFAASVKSEIGGELAA-SSG----VSTPG--------SVGHDIITE QPR-SQHTLQA-DSVDLSGCD-----------LTSAATDGDEEDILSHSSSQFSAVPSDP AMDLNDG-TQ--------------ASSPISDSSQTTTEGPDSAVTPSDSSEI-------- -------------------------------------------------------VLDGA DSQYLGMQIGQPQEDD-EEGAAGVL----------------------------------- --SGEVSDVFRNSSLALQQAHLLERM-------------------GHSRQPSDSSIDKYV TRDEVAEASDPESKPCRIKGDI----GQPNDD---DSAPLVHCV---------------- -------RLLSASF-LLTGEKKALVPDRDVRVSVKALALSCIGA-AVALHPESFFSRLYK VP---------------------------------------------------------- ------------------------------------------------------------ -----------------------------LNTT-ESTEEQ-----YVSDI---LNYIDHG DPQVRGATAILCGTLVYSI----------------------------------------- --------------------------------------------LSRSRLRVGDWLGNIR TLTGNT-F---SLVDCIPLLQKTLKDE-SSVTCKLACTAVRHCVLSLC------------ -SSSYSDLGLQ--------------------------------------------LLIDM LPLKNSSYWLVRTELLDTLAEIDFRLVSFLEAK----AESLHRGAHHYTG---------- -----------FLKLQERVLNNVVIYLLGDEDPRVRHVAATSLTRLVPK----------- --------------LF--------------YKCDQG---------QADPVVAVARDQSSV Y-----LKLLMHETQPPSHFSVSTI-TRIYRGYSLLPSITDV-TMEN-NLSRVVAAVSHE LITSTTRALTFGCCEALCLLSAAFPVCTWSLGWHC-G----------------------- VPPLSAS----------DESRKSCTV------GMASMILTL--LSSA-------WFPLDL SAHQDA----LILAGNLLAASAPKSLR--SSWTSEEEANSAAT-------RQEEIWPALG DRTLVPLVEQLFSHLLKVINICAHVLDDV-TPGPAI--------------KAALPSLTNP P----SLSPIR-------RKGKEKEPGEQASTPMSPK----K---VGEASAASRQSDTSG PVTA--SKSSSLGSFYHLPSYLKLHDVLKATHANYKVTLDLQNSTEKFGGFLRSALDVLS QILE--LATLQDIGKCVEEVLGYLKSCFSREPMMATVCVQQLLKTLFGTNLASQFDGLSS N--PS---KSQCRAQRLGSSS--VRP-------GLYHYCFMAPYTHFTQALADASLRNMV -QAEQERDASGWFDVLQKVSAQLKTNLTSVTKN-RADKNAIHNHIRLFEPLVIKALKQYT TTTSVQL-QKQVLDLLAQLVQLRVNYCLLDSDQVFIGFVLKQFEYIEVGQF--------- -RESEAIIPNIFFFLVLLSYER--Y-----HSKQIIGIPKIIQLCDGIMASGRKAVTHAI PALQPIVHDLFVL-------------------------------RG--TNKADAG----- ------------------KELETQKEVVVSMLL-RLIQ---YHQVLEMFILVLQQCHKEN -----------EDKWKR---------LSRQVADIILP----------------MLAKQQM HIDSHEALGVLNTLFEILAPSSL---RPVDMLLRSMF----------------------I TPST----MASVSTVQLWISGILAILRVLISQSTEDIVLCRIQ----------ELSFSPH LLSCPVI-NRLRGGGGN-VTLG--------ECSEGKQ-KSLPEDTFSRFLLQLVGILLED IV--TKQLKVDMSEQQHT-FYCQELGTLLMCLIHIFKSGMFRRITAAATRLFTSD---GC EGS-FYTLESLNAR---------VRSMVPTHPALVLLWC-----------------QILL LINHTDHR-WWAEVQQTPKRHSLSCTKSLNPQKSGEEEDSGSAAQLGM---CNREIVRRG ALILFCDYVCQNLHDS------EHLTWLIVNHIQDLISLSH------EPPVQDFISAIHR NSAAS----GLFIQAIQ-----SRCENLSTPTTLKKTL-QCLEGIHLSQS---GAVLTLY VD-RLLGTPFRALAR-------MVDTLACRRVEMLLAANLQSSMAQLPEEELNRIQEHLQ NSGLAQRH---QRLYSLLDRFRLSTVQDSLSPL-------------PPVTSHPLDGDGHT SLETVSPDKDWYLQLVRSQ----CWTRSDSAL-------LEGAELVNRIPAED-MNDFMM SS--EFNLSLLAPCL-SLGMSEIANGQK----------------------------SPL- ----FEAARGVILNRV----TSVVQQLPAVH---------QVFQPFLPIEPTA------- ------------YWNKLNDLLGDTTSYQSLTILARALAQYLVVLSKVPAHLHLPPEKEGD TVKFVVMTVEALSWHLIHEQIPLSLDLQAGLDCCCLALQ-VPGLW--------------- -------------------GVLSSPEYVTHACSLIHCV---------------RFILEAI AVQPG------------------DQLLGPESRSHTPRAVR--KEEVDSDIQNL-SHVTSA ---CEMVADMVE-----------SLQSVLALGHKRN------------------------ ---------------------STLPSFLTA--VLKNIVISLARLPLVNSYTRVPPLVW-- --------KLGWSPKPGGDFGTV-------------FPEIPVEFLQEKEILKEFIYRINT LGWTNRTQFEETWATLLGVLVTQP--------LVMEQEES----PPEEDTERTQIHVLAV QAITSLVLSAMTVPVAGNPAVSCLEQQPRNK-PLKALDTRFGRKLSMIRGIVEQEIQEMV S--------QRENTATHHSHQAWDPVP-SLLPAT-TGALISH---------DKLLLQ--- --INPEREPGNMSYKLGQVS----------------IHSVWLG----------NNITPLR EEEWDEE--------------------------EEEESDVPAPTSPPVSPVNSRKHR--- --AGV-------------DIHSCSQFLLELYSRWI--------LPSSAA-RRTPVILISE VVRSLLVVSDLFTERTQFEMMYLTLTELRRVHPSEDE----ILIQYLVPATCKAAAVLGM DK-------TVAEPVSR-----------------------LLES-TLRSSH--------- ---LPSQIGALHGILYVLECDLLDDTAKQ--------LIPVVSDYLLSNLKGIAHCVNI- ------------------------------------------------------------ -------------------HSQ-QHVLVMCATAFYLMENYPLDVG----------PEFSA SVIQMCGVMLSGSE-ESTPSI----IYH------------------CALRGLERLLLSE- -----------------------------QLSRLDTESLVKLSVDRVNVQS-PHRAMAAL GLMLTCMYT-------------------------------------GKEKASP-GRASDP SPAT-PDSESVI----VAMERVS-----VLFDRIR--------------KGFPCEARVVA RILPQFLDDF---------FPPQD-------VMNKVIGEFLSN-QQPYPQFMATVVYKVF QTLHSAGQSSMV-RDWVMLSLSNFTQRTPVAMAMWSLSCFLVSASTSPWVSAILPHVIS- ------------------------------------------------------------ ---RMGKLE-QVDVNLFCLVATDFYRHQIEEE------FDRRAFQSVFEVVAA---PGSP YHRLLACLQNVHKVTTC-------------------- Nomascus_leucogenys -----MTPLGGTATRSEQRCAPIQKRPQVGTHSCGRHLVAIAASRCTNHSASVGSRRRPP GPAPDPLLPSGALRWDRWGAPGAPQQAPRRAVQLMKAFESLKSF--------------QQ QQQQQQQQPPPPPPPPP?SASQPPPQAQPLL-?QPQ-PPPPPPPPPPGPAVAEEPLHRPK KELSATKKDRVNH-CLTICENIVAQSVRNSPE-FQKLLGIAMELFLLCSDDAESDVRMVA DECLNKVIKA-----LMDSNLPRLQLELYKEIKKNGAPRSLRAALWRFAELAHLVRPQKC -RPYLVNLLPCLTRTSKRPEESV-QETLAAAVPKIMASFGNFANDNE-IKVLLKAFIANL KSSSPTIRRTAAGSAVSICQHSRRT-QYFYSWLLNVLLGLLVPVEDE-HSTLLILGVLLT LRYLVPLLQQQV-KDTSLKGSFG----------VTRKEMEVSP-SAEQLVQVYELTLHHT QHQ---DHNVVTGALELLQQLFRTPPP-----------ELLQTLTTVGGIGQ-------- -------------LTAAKEQSGGRSRSGSIVELIAGGGSSCSPVLSRKQKGKVLLGEEEA LEDDSESRSDVSSSALAASVKDEISGELAA-SSG----VSTPG--------SAGHDIITE QPR-SQHTLQA-DSVDLAGCD-----------LTSSATDGDEEDILSHSSSQVSAVPSDP AMDLNDG-TQ--------------ASSPISDSSQTTTEGPDSAITPSDSSEI-------- -------------------------------------------------------VLDGT DNQYLGLQIGQPQDED-EE-ATGIL----------------------------------- --PDEASEAFRNSSMALQQAQLLKNT-------------------SHSRQPSDSSVDKFV LRDEATELGDQENKPCRVKGDI----GQSTDD---DSAPLVHCV---------------- -------RLLSASF-LLTGGKNVLVPDRDVRVSVKALALSCVGA-AVALHPESFFSKLYK VP---------------------------------------------------------- ------------------------------------------------------------ -----------------------------LDTT-EYPEEQ-----YVSDI---LNYIDHG DPQVRGATAILCGTLICSI----------------------------------------- --------------------------------------------LSRSRFHVGDWMGTIR TLTGNT-F---SLADCIPLLRKTLKDE-SSVTCKLACTAVRHCVMSLC------------ -SSSYSELGLQ--------------------------------------------LIIDV LTLRNSSYWLVRTELLETLAEIDFRLVSFLEAK----AENLHRGAHHYTG---------- -----------LLKLQERVLHNVVIHLLGDEDPRVRHVAAASLIRLVPK----------- --------------LF--------------YKCDQG---------QADPVVAVARDQSSV Y-----LKLLMHETQPPSHFSVSTI-TRIYRGYNLLPSITDV-TMEN-NLSRVIAAVSHE LITSTTRALTFGCCEALCLLSTAFPVCIWSLGWHC-G----------------------- VPPLSAS----------DESRKSCTV------GMATMILTL--LSSA-------WFPLDL SAHQDA----LILAGNLLAASAPKSLR--SSWASEEEANPAAT-------KQEEVWPALG DRALVPMVEQLFSHLLKVINICAHVLDDV-APGPAI--------------KAALPSLTNP P----SLSPIR-------RKGKEKEPGEQASVPLSPK----K---GSEASAASRQSDTSG PVIT--SKSSSLGSFYHLPSYLKLHDVLKATHANYKVTLDLQNSTEKFGGFLRSALDVLS QILE--LATLQDIGKCVEEILGYLKSCFSREPMMATVCVQQLLKTLFGTNLASQFDGLSS N--PS---KSQGRAQRLGSSS--VRP-------GLYHYCFMAPYTHFTQALADASLRNMV -QAEQEHDTSGWFDVLQKVSTQLKTNLTSVTKN-RADKNAIHNHIRLFEPLVIKALKQYT TTTSVQL-QKQVLDLLAQLVQLRVNYCLLDSDQVFIGFVLKQFEYIEVGQF--------- -RESEAIIPNIFFFLVLLSYER--Y-----HSKQIIGIPKIIQLCDGIMASGRKAVTHGD ------------------------------------------------------------ -------------------------------------------------VICPAAVHKEN -----------EDKWKR---------LSRQIADIILP----------------MLAKQQM HIDSHEALGVLNTLFEILAPSSL---RPVDMLLRSMF----------------------V TPNT----MASVSTVQLWISGILAILRVLISQSTEDIVLSRIQ----------ELSFSPY LISCPVI-NRLRDGDCN-SVLE--------EHSEGKQMKNLPEETFSRFLLQLVGILLED IV--TKQLKVEMSEQQHT-FYCQELGTLLMCLIHIFKSGMFRRITAAATRLFRSD---GC GGS-FYTLDSLNLR---------ARSMITTHPALVLLWC-----------------QILL LVNHTDYR-WWAEVQQTPKRHSLSSTKLLSPQMSGEEEDSDLAAKLGM---CNREIVRRG ALILFCDYVCQNLHDS------EHLTWLIVNHIQDLISPPR-------APVQNFISAVHR KLCCQ----RLFIQTIQ-----SRCENLSTPTTLKKTL-QCLEGIHLSQS---GAVLTLY VD-RLLCTPFRVLAR-------MVDILACRRVEMLLAANLQSSMAQLPMEELNRIQEYLQ SSGLAQRH---QRLYSLLDRFRLSTMQDSLSPS-------------PPVSSHPLDGDGHV SLETVSPDKDWYIHLVKSQ----CWTRSDSAL-------LEGAELVNRIPAED-MSAFMM NS--EFNLSLLAPCL-SLGMSEISGGQK----------------------------SPL- ----FEAAREVTLARV----SGTVQQLPAVH---------HVFQPDLPAEPAA------- ------------YWSKLNDLFGDAALYQSLPTLARALAQYLVVVSKLPSHLHLPPEKEKD IVKFVVATLEALSWHLIREQIPLSLDLQAGLDCCCLALQ-LPGLW--------------- -------------------SVVSSTEFVTHACSLIHCV---------------HFILEAV AVQPG------------------EQLLSPERRTNTPKAIREEEEEVDPNTQNP-KYITAA ---CEMVAEMVE-----------SLQSVLALGHKRN------------------------ ---------------------SGVPAFLTS--VLRNIIISLARLPLVNSYTRVPPLVW-- --------KLGWSPKPGGDFGTA-------------FPEIPVEFLQEKEVFKEFIYRINT LGWTSRTQFEETWATLLGVLVTQP--------LVMEQEES----PPEEDTERTQINVLAV QAITSLVLSAMTVPVAGNPAVSCLEQQPRNK-PLKALDTRFGRKLSIIRGIVEQEIQAMV S--------KRENIATHHLYQAWDPVP-SLSPAT-TGALISH---------EKLLLQ--- --INPERELGSMSYKLGQVS----------------IHSMWLG----------NSITPLR EEEWDEE--------------------------EEEEADAPAPSSPPTSPVNSRKHR--- --AGV-------------DIHSCSQFLLELYSRWI--------LPSSSA-RRTPAILISE VVRSLLVVSDLFTERNQFELMYVTLTELRRVHPSEDE----ILAQYLVPATCKAAAVLGM DK-------AVAEPVSR-----------------------LLES-TLRSSH--------- ---LPSRVGALHGVLYVLECDLLDDTAKQ--------LIPVISDYLLSNLKGIAHCVNI- ------------------------------------------------------------ -------------------HSQ-QHVLVMCATAFYLIENYPLDVG----------PEFSA SIIQMCGVMLSGSE-ESTPSI----IYH------------------CALRGLERLLLSE- -----------------------------QLSRLDAESLVKLSVDRVNVHS-PHRAMAAL GLMLTCMYT-------------------------------------GKEKVSP-GRTSDP NSAA-PDSESVI----VAMERVS-----VLFDRIR--------------KGFPCEARVVA RILPQFLDDF---------FPPQD-------IMNKVIGEFLSN-QQPYPQFMATVVYKVF QTLHSTGQSSMV-RDWVMLSLSNFTQRTPVAMATWSLSCFFVSASTSPWVAAILPHVIS- ------------------------------------------------------------ ---RMGKLE-QVDVNLFCLVATDFYRHQIEEE------LDRRAFQSVFEVVAA---PGSP YHRLLTCLRNVHQVPTC-------------------- Pan_troglodytes MYYVPGTVLGA------------------------------------------------- -----------------------GLSSEQTKLCPHEAFILMKDI---------------- -----------------------------------------------------DSKQDRK KELSATKKDRVNH-CLTICENIVAQSVRNSPE-FQKLLGIAMELFLLCSDDGESDVRMVA DECLNKVIKA-----LMDSNLPRLQLELYKEIKKNGAPRSLRAALWRFAELAHLVRPQKC -RPYLVNLLPCLTRTSKRPEESV-QETLAAAVPKIMASFGNFANDNE-IKVLLKAFIANL KSSSPTIRRTAAGSAVSICQHSRRT-QYFYSWLLNVLLGLLIPVEDE-HSTLLILGVLLT LRYLVPLLQQQV-KDTSLKGSFG----------VTRKEMEVSP-SAEQLVQVYELTLHHT QHQ---DHNVVTGALELLQQLFRTPPP-----------ELLQTLTAVGGIGQ-------- -------------LTAAKEESGGRSRSGSIVELIAGGGSSCSPVLSRKQKGKVLLGEEEA LEDDSESRSDVSSSALTASVKDEISGELAA-SSG----VSTPG--------SAGHDIITE QPR-SQHTLQA-DSVDLASCD-----------LTSSATDGDEEDILSHSSSQVSAVPSDP AMDLNDG-TQ--------------ASSPISDSSQTTTEGPDSAVTPSDSSEI-------- -------------------------------------------------------VLDGT DNQYLGLQIGQSQDED-EE-ATGIL----------------------------------- --PEEASEAFRNSSMALQQAHLLKNM-------------------SHSRQPSDSSVDKFV LRDEATEPGDQENKPCRIKGDI----GQSTDD---DSAPLVHCV---------------- -------RLLSASF-LLTGGKNVLVPDRDVRVSVKALALSCVGA-AVALHPESFFSKLYK VP---------------------------------------------------------- ------------------------------------------------------------ -----------------------------LDTT-EYPEEQ-----YVSDI---LNYIDHG DPQVRGATAILCGTLICSI----------------------------------------- --------------------------------------------LSRSRFHVGDWMGTIR TLTGNT-F---SLADCIPLLRKTLKDE-SSVTCKLACTAVRHCVMSLC------------ -SSSYSELGLQ--------------------------------------------LIIDV LTLRNSSYWLVRTELLETLAEIDFRLVSFLEAK----AENLHRGAHHYTG---------- -----------LLKLQERVLNNVVIHLLGDEDPRVRHVAAASLIRLVPK----------- --------------LF--------------YKCDQG---------QADPVVAVARDQSSV Y-----LKLLMHETQPPSHFSVSTI-TRIYRGYNLLPSITDV-TMEN-NLSRVIAAVSHE LITSTTRALTFGCCEALCLLSTAFPVCIWSLGWHC-G----------------------- VPPLSAS----------DESRKSCTV------GMATMILTL--LSSA-------WFPLDL SAHQDA----LILAGNLLAASAPKSLR--SSWASEEEANPAAT-------KQEEVWPALG DRALVPMVEQLFSHLLKVINICAHVLDDV-APGPAI--------------KAALPSLTNP P----SLSPIR-------RKGKEKEPGEQASVPLSPK----K---GSEASAASRQSDTSG PVTT--SKSSSLGSFYHLPSYLKLHDVLKATHANYKVTLDLQNSTEKFGGFLRSALDVLS QILE--LATLQDIGKCVEEILGYLKSCFSREPMMATVCVQQLLKTLFGTNLASQFDGLSS N--PS---KSQGRAQRLGSSS--VRP-------GLYHYCFMAPYTHFTQALADASLRNMV -QAEQEHDTSGWFDVLQKVSTQLKTNLTSVTKN-RADKNAIHNHIRLFEPLVIKALKQYT TTTSVQL-QKQVLDLLAQLVQLRVNYCLLDSDQVFIGFVLKQFEYIEVGQF--------- -RESEAIIPNIFFFLVLLSYER--Y-----HSKQIIGIPKIIQLCDGIMASGRKAVTHAI PALQPIVHDLFVL-------------------------------RG--TNKADAG----- ------------------KELETQKEVVVSMLL-RLIQ---YHQVLEMFILVLQQCHKEN -----------EDKWKR---------LSRQIADIILP----------------MLAKQQM HIDSHEALGVLNTLFEILAPSSL---RPVDMLLRSMF----------------------V TPNT----MASVSTVQLWISGILAILRVLISQSTEDIVLSRIQ----------ELSFSPY LISCTVI-NRLRDGDSN-STLE--------EHSEGKQIKNLPEETFSRFLLQLVGILLED IV--TKQLKVEMSEQQHT-FYCQELGTLLMCLIHIFKSGMFRRITAAATRLFRSD---GC GGS-FYTLDSLNLR---------ARSMITTHPALVLLWC-----------------QILL LVNHTDYR-WWAEVQQTPKRHSLSSTKLLSPQMSGEEEDSDLAAKLGM---CNREIVRRG ALILFCDYVCQNLHDS------EHLTWLIVNHIQDLISLSH------EPPVQDFISAVHR NSAAS----GLFIQAIQ-----SRCENLSTPTTLKKTL-QCLEGIHLSQS---GAVLTLY VD-RLLCTPFRVLAR-------MVDILACRRVEMLLAANLQSSMAQLPMEELNRIQEYLQ SSGLAQRH---QRLYSLLDRFRLSTMQDSLSPS-------------PPVSSHPLDGDGHV SLETVSPDKDWYIHLVKSQ----CWIRSDSAL-------LEGAELVNRIPAED-MSAFMM NS--AFNLSLLAPCL-SLGMSEISGGQK----------------------------SAL- ----FEAAREVTLARV----SGTVQQLPAVH---------HVFQPELPAEPAA------- ------------YWSKLNDLFGDAALYQSLPTLARALAQYLVVVSKLPSHLHLPPEKEKD IVKFVVATLEALSWHLIHEQIPLSLDLQAGLDCCCLALQ-LPGLW--------------- -------------------SVVSSTEFVTHACSLIHCV---------------HFILEAV AVQPG------------------EQLLSPERRTNTPKAISEEEEEVDPNTQNP-KYITAA ---CEMVAEMVE-----------SLQSVLALGHKRN------------------------ ---------------------SGVPAFLTP--VLRNIIISLARLPLVNSYTRVPPLVW-- --------KLGWSPKPGGDFGTA-------------FPEIPVEFLQEKEVFKEFIYRINT LGWTSRTQFEETWATLLGVLVTQP--------LVMEQEES----PPEEDTERTQINVLAV QAITSLVLSAMTVPVAGNPAVSCLEQQPRNK-PLKALDTRFGRKLSIIRGIVEQEIQAMV S--------KRENIATHHLYQAWDPVP-SLSPAT-TGALISH---------EKLLLQ--- --INPERELGSMSYKLGQVS----------------IHSVWLG----------NSITPLR EEEWDEE--------------------------EEEEADAPAPSSPPTSPVNSRKHR--- --AGV-------------DIHSCSQFLLELYSRWI--------LPSSSA-RRTPAILISE VVRSLLVVSDLFTERNQFELMYVTLTELRRVHPSEDE----ILAQYLVPATCKAAAVLGM DK-------AVAEPVSR-----------------------LLES-TLRSSH--------- ---LPSRVGALHGVLYVLECDLLDDTAKQ--------LIPVISDYLLSNLKGIAHCVNI- ------------------------------------------------------------ -------------------HSQ-QHVLVMCATAFYLIENYPLDVG----------PEFSA SIIQMCGVMLSGSE-ESTPSI----IYH------------------CALRGLERLLLSE- -----------------------------QLSRLDAESLVKLSVDRVNVHS-PHRAMAAL GLMLTCMYT-------------------------------------GKEKVSP-GRTSDP NPAA-PDSESVI----VAMERVS-----VLFDRIR--------------KGFPCEARVVA RILPQFLDDF---------FPPQD-------IMNKVIGEFLSN-QQPYPQFMATVVYKVF QTLHSTGQSSMV-RDWVMLSLSNFTQRAPVAMATWSLSCFFVSASTSPWVAAILPHVIS- ------------------------------------------------------------ ---RMGKLE-QVDVNLFCLVATDFYRHQIEEE------LDRRAFQSVLEVVAA---PGSP YHRLLTCLRNVHKVTTC-------------------- Panthera_pardus -----MATLEK------------------------------------------------- ---------------------------------LMKAFESLKSF---------QQQQQQQ QQQQQPQPQPPPPPPPPPQPPQPLPQAQPPL-----PQPQP?PPPPPGPAVAEEPLHRPK KELSATKKDRVNH-CLTICENIVAQSLRNSPE-FQKLLGIAMELFLLCSDDAESDVRMVA DECLNRVIKA-----LMDSNLPRLQLELYKEIKKNGAPRSLRAALWRFAELAHLVRPQKC -RPYLVNLLPCLTRISKRPEESV-QETLAAAVPKIMASFGNFANDNE-IKVLLKAFIANL KSSSPTIRRTAAGSAVTICQHSRRT-QYFYSWLLNVLLGLLVPVEDE-HSTLLILGVLLT LRYLVPLLQQQV-KDTSLKGSFG----------VTRKEMEVCP-STEQLIQVYELTLHYT QHQ---DHNAVTGALELLQQLFRTPPP-----------ELLQALTAPGG-GQ-------- -------------RSGAQYGPGGRSRSGSIAELLAGGGSSCSPVLSRKQKGKVLFGDAAA LEDDSESRSEGSSPAFAASVKGEIGGELAA-SSG----VSTPG-------DSVGHDIITE QPR-SQHTLQP-DSVDLAGCD-----------LASAATDGDEEDILSHSSSQISAVPSDP AMDLNDG-TQ--------------ASSPVSDSSQTTTEGPDSAVTPSDSSEI-------- -------------------------------------------------------VLDGA DSQYSGMQIGQPQDED-EE-AAGIL----------------------------------- --PEEDVDAFRNSAAALQQAHLLKSM-------------------GHSRRPSDSSVDTFV SRDEAAEAGDQENKPCRIKGDI----GQSTDD---DSVPLVHCV---------------- -------RLLSASF-LLTGEKNVLVPDRDVRVSVKALALSCVGA-AVALHPESFFSKLYK VP---------------------------------------------------------- ------------------------------------------------------------ -----------------------------LDSV-EYPEEP-----YVSDI---LNYIDHG DPQVRGATAVLCGTLISST----------------------------------------- --------------------------------------------LSRSRFQVGDWMGTVR ALTGNT-F---SLEDCIPLLRKTLKDE-SSVTCKLACTAVRHCVMSLC------------ -SSSSSELGLQ--------------------------------------------LITDV LSLRDSSYWLVRTELLETLAEIDFRLVSFLEAK----AENLHRGAHHYTG---------- -----------LLKLQDRVLHDVVIYLLGDEDPRVRHVAAAALMRLVPK----------- --------------LF--------------YKCDQG---------QADPVVAVARDQSSV Y-----LKLLMHETQPPSHFSVSTI-TRIYRGYNLLPSMTDV-TVEN-NLSRVIAAVSHE LVTSTTRALTFGCCEALCLLSTAFPVCVWSLGWHC-G----------------------- APPLSVS----------GESRKSCTV------GMATVILTL--LSSA-------WFPLDL AAHQDA----LVLAGNLLAASAPRSLR--SSWTSEEEANPAAA-------KQEEVWPALG DRTLVPMVEQLFSHLLKVINICAHVLDDV-APGPAI--------------KAALPSLTNP P----SLSPIR-------RKGKEKEPGEQASAPLSPK----K---GSEASPASRQSDASG PVTA--NKSSSLGSFYHLPSYLKLHDVLKATHANYKVTLDLQNSAEKFGGFLRSALDVLS QILE--LATLQDIGKCVEEILGYLKSCFSREPMMATVCVQQLLKTLFGTNLASQFDGLSS N--PS---KSQGRAQRLGSSS--VRP-------GLYHYCFMAPYTHFTQALADASLRNMV -QAEQDHDASGWFDVLQKVSTQLKTNLTSTTKN-RADKNAIHNHIRLFEPLVIKALKQYT TTTSVQL-QRQVLDLLAQLVQLRVNYCLLDSDQVFIGFVLKQFEYIEVGQF--------- -RESEAIIPNIFFFLVLLSYER--Y-----HSKQIIGIPKIIQLCDGIMASGRKAVTHAI PALQPIVHDLFVL-------------------------------RG--ANKADAG----- ------------------KELETQKEVVVSMLL-RLIQ---YHQVLEMFILVLQQCHKES -----------EDKWKR---------LSRQIADVILP----------------MLAKQQM HIDSHEALGVLNTLFEILAPSSL---RPVDMLLRSMF----------------------V TPDT----MAPVSTVQLWISGILAILRVLISQSTEDIVLSRIQ----------ELSFSPY LISCPII-NRLREGDST-STPE--------EHNEGRQMKSLPEETFSRFLLQLVGILLED IV--TKQLKVEMSEQQHT-FYCQELGTLLMCLIHIFKSGMFRRITAAASRLLTVD---SS DSS-FYGLDRLNAQ---------VRAMVPTHPALVLLWC-----------------QILL LVSHTDHR-WWAEVQQTPRRRSLSSTKSLSPQMSGEEGDSDAASKPGM---CNREIVRRG ALILFCDYVCQNLHDS------EHLTWLIVNHIQDLINLSH------EPPVQDFISAVHR NSAAS----GLFIQAIQ-----SRCENLSAPTTLKKTL-QCLEGIHLSQS---GAVLTLY VD-KLLCTPIRVLAR-------MVDTLACRRVEMLLAANLQSSMAQLPVEELTRIQEYLQ SSGLAQRH---QRLYSLLDRLRLATAPGSRGPS-------------PPVTSHPLDGDGPL ALETVIPDKDWYLRLVKSQ----CWTRSDSAL-------LEGAELVNRIPPSD-MSTFMM NS--EFNLSLLAPCL-GLGVREVSGGQR----------------------------SPL- ----FEAARLATLDRV----TGLVQQLPAAH---------HVFQPFLPAEPTA------- ------------YWNKLNDLFGDAVLYRSLTTLARALAQYLLVFSKLPGHLHLPPEKERD TVKFVVMTLEALSWHLIHEQIPLSLDLQAGLDCCCLALQ-LPSVW--------------- -------------------SALSSPEMVTHACSLIHCV---------------RFILEAI VVQPG------------------DQLLSPDRRMNTPKAAR--EDEVDSNTQNP-AYITAA ---CGMVAEMVE-----------ALPSVLALGHKRN------------------------ ---------------------SSTPAFLTS--VLRNIIISLARLPLVNSYTRVPPLVW-- --------KLGWSPKPGGDFGTA-------------FPEIPVEFLQEKEVFKEFIYRINT LGWTSRTQFEETWATLLGVLVTQP--------LVMEQEES----PPEEDTERTQINVLAV QAITSLVLSAMTVPVAGNPAVSCLEQQPRNK-PLKALDTRFGRKLSIIRGIVEQEIQAMV S--------KRENVATHHLYQAWDPVP-SLSPAT-TGALIGH---------DKLLLQ--- --INPERELGNMSYKLGQVS----------------IHSVWLG----------NSITPLR EEEWEEE--------------------------EEEEADVPTSASPPTSPVNSRKHR--- --AGV-------------DIHSCSQFLLELYSRWI--------LPSGSA-RRTPIILISE VVRSLLVVSDLFTERTQFEMMYLTLTELRRAHPAEDE----ILIQYLVPATCKAAAVLGM DK-------AVAEPVSR-----------------------LLES-TLRSSH--------- ---LPSRVGALHGALYVLECDLLDETAKQ--------LVPVISDYLLSNLKGAAHCVNV- ------------------------------------------------------------ -------------------HSQ-QHVLVMCATAFYLIENYPLDVG----------PEFSA SVIQMCGVMLSGSE-ESTPSI----IYH------------------CVLRGLERLLLSE- -----------------------------QLCRLDAESLVKLSVDRVNVHS-PHRAMAAL GLMLTCMYT-------------------------------------GKEKISP-GRTSDP SPAA-PDSESVI----VAMERVS-----VLFDRVR--------------KGFPCEARVVA RILPQFLDDF---------FPPQD-------VMNKVIGEFLSN-QQPYPQFMATVVYKVF QTLHSSGQSSMV-RDWVMLSLSNFTQRSPVAMAVWSLSCFFVSASTSPWVSAVLPHVIS- ------------------------------------------------------------ ---RMGKLE-RVDVNLFCLVATDFYRHQIEEE------LDRRAFQSVFEVVAA---PGNP YHRLLTCLRNVHKVASC-------------------- Pongo_abelii -----MATLEK------------------------------------------------- ---------------------------------LMKAFESLKSF------------QQQQ QQQQQQPPPPPPPPPPPPQLPQPPPQAQPLL-PQQQ-PPPPPPPPPPGPAVAEEPLHRPK KELSATKKDRVNH-CLTICENIVAQSVRNSPE-FQKLLGIAMELFLLCSDDAESDVRMVA DECLNKVIKA-----LMDSNLPRLQLELYKEIKKNGAPRSLRAALWRFAELAHLVRPQKC -RPYLVNLLPCLTRTSKRPEESV-QETLAAAVPKIMASFGNFANDNE-IKVLLKAFIANL KSSSPTIRRTAAGSAVSICQHSRRT-QYFYSWLLNVLLGLLVPVEDE-HSTLLILGVLLT LRYLVPLLQQQV-KDTSLKGSFG----------VTRKEMEVSP-SAEQLVQVYELTLHHT QHQ---DHNVVTGALELLQQLFRTPPP-----------ELLQTLTTVGGIGQ-------- -------------LTAAKEESGGRSRSGSIVELIAGGGSSCSPVLSRKQKGKVLLGEEEA LEDDSESRSDVSSSALAASVKDEISGELAA-SSG----VSTPG--------SAGHDIITE QPR-SQHTLQA-DSVDLAGCD-----------LTSSATDGDEEDILSHSSSQVSAVPSDP AMDLNDG-TQ--------------ASSPISDSSQTTTEGPDSAVTPSDSSEI-------- -------------------------------------------------------VLDGT DNQYLGLQIGQPQDED-EE-ATGIL----------------------------------- --PDEASEAFRNSSMALQQAHLLKNM-------------------SHSRQPSDSSVDKFV LRDEATEPGDQENKPCRIKGDI----GQSTDD---DSAPLVHCV---------------- -------RLLSASF-LLTGGKNVLVPDRDVRVSVKALALSCVGA-AVALHPESFFSKLYK VP---------------------------------------------------------- ------------------------------------------------------------ -----------------------------LDTT-EYPEEQ-----YVSDI---LNYIDHG DPQVRGATAILCGTLICSI----------------------------------------- --------------------------------------------LSRSRFHVGDWMGTIR TLTGNT-F---SLADCIPLLRKTLKDE-SSVTCKLACTAVRHCAMSLC------------ -SSSYSELGLQ--------------------------------------------LIIDV LTLRNSSYWLVRTELLETLAEMDFRLVSFLEAK----AENLHRGAHHYTG---------- -----------LLKLQERVLNNVVIHLLGDEDPRVRHVAAASLIRLVPK----------- --------------LF--------------YKCDQG---------QADPVVAVARDQSSV Y-----LKLLMHETQPPSHFSVSTI-TRIYRGYNLLPSITDV-TMEN-NLSRVIAAVSHE LITSTTRALTFGCCEALCLLSTAFPVCIWSLGWHC-G----------------------- VPPLSAS----------DESRKSCTV------GMATMILTL--LSSA-------WFPLDL SAHQDA----LILAGNLLAASAPKSLR--SSWASEEEANPAAT-------KQEEVWPALG DRALVPMVEQLFSHLLKVINICAHVLDDV-APGPAI--------------KAALPSLTNP P----SLSPIR-------RKGKEKEPGEQASVPLSPK----K---GSEASAASRQSDTSG PVTT--SKSSSLGSFYHLPSYLKLHDVLKATHANYKVTLDLQNSTEKFGGFLRSALDVLS QILE--LATLQDIGKCVEEILGYLKSCFSREPMMATVCVQQLLKTLFGTNLASQFDGLSS N--PS---KSQGRAQRLGSSS--VRP-------GLYHYCFMAPYTHFTQALADASLRNMV -QAEQEHDTSGWFDVLQKVSTQLKTNLTSVTKN-RADKNAIHNHIRLFEPLVIKALKQYT TTTSVQL-QKQVLDLLAQLVQLRVNYCLLDSDQVFIGFVLKQFEYIEVGQF--------- -RESEAIIPNIFFFLVLLSYER--Y-----HSKQIIGIPKIIQLCDGIMASGRKAVTHAI PALQPIVHDLFVL-------------------------------RG--TNKADAG----- ------------------KELETQKEVVVSMLL-RLIQ---YHQVLEMFILVLQQCHKEN -----------EDKWKR---------LSRQIADIILP----------------MLAKQQM HIDSHEALGVLNTLFEILAPSSL---RPVDMLLRSMF----------------------V TPNT----MASVSTVQLWISGILAILRVLISQSTEDIVLSRIQ----------ELSFSPY LISCPVI-NRLRDGDSN-STLE--------EHSEGKQIKNLPEETFSRFLLQLVGILLED IV--TKQLKVEMSEQQHT-FYCQELGTLLMCLIHIFKSGMFRRITAAATRLFRSD---GC GGS-FYTLDSLNLR---------ARSMITTHPALVLLWC-----------------QILL LVNHTDYR-WWAEVQQTPKRHSLSSTKLLSPQMSGEEEDSDLAAKLGI---CNREIVRRG ALILFCDYVCQNLHDS------EHLTWLIVNHIQDLISLSH------EPPVQDFISAVHR NSAAS----GLFIQAIQ-----SRCENLSTPTTLKKTL-QCLEGIHLSQS---GAVLTLY VD-RLLCTPFRVLAR-------MVDILACRRVEMLLAANLQSSMAQLPMEELNRIQEYLQ SSGLAQRH---QRLYSLLDRFRLSSMQDSLSPS-------------PPVSSHPLDGDGHV SLETVSPDKDWYIHLVKSQ----CWTRSDSAL-------LEGAELVNRIPAED-MSAFMM NS--EFNLSLLAPCL-SLGMSEISGGQK----------------------------SPL- ----FEAAREVTLARV----SGTVQQLPAVH---------HVFQPGLPAEPAA------- ------------YWSKLNDLFGDAALYQSLPTLARALAQYLVVVSKLPSHLHLPPEKEKD IVKFVVATLEALSWHLIHEQIPLSLDLQAGLDCCCLALQ-LPGLW--------------- -------------------SVVSSTEFVTHACSVIHCV---------------HFILEAV AVQPG------------------EQLLSPERRTNTPKVIR-EEEQVDPNTQNP-KYITAA ---CEMVAEMVE-----------SLQSVLALGHKRN------------------------ ---------------------SGVPAFLTS--VLRNIIISLARLPLVNSYTRVPPLVW-- --------KLGWSPKPGGDFGTA-------------FPEIPVEFLQEKEVFKEFIYRINT LGWTSRTQFEETWATLLGVLVTQP--------LVMEQEES----PPEEDTERTQINVLAV QAITSLVLSAMTVPVAGNPAVSCLEQQPRNK-PLKALDTRFGRKLSIIRGIVEQEIQAMV S--------KRENIATHHLYQAWDPVP-SLSPAT-TGALISH---------EKLLLQ--- --INPERELGSMSYKLGQVS----------------IHSMWLG----------NSITPLR EEEWDEE--------------------------EEEEADAPAPSSPPTSPVNSRKHR--- --AGV-------------DIHSCSQFLLELYSRWI--------LPSSSA-RRTPAILISE VVRSLLVVSDLFTERNQFELMYVTLTELRRVHPSEDE----ILAQYLVPATCKAAAVLGM DK-------AVAEPVSR-----------------------LLES-TLRSSH--------- ---LPSRVGALHGVLYVLECDLLDDTAKQ--------LIPVISDYLLSNLKGIAHCVNI- ------------------------------------------------------------ -------------------HSQ-QHVLVMCATAFYLIENYPLDVG----------PEFSA SIIQMCGVMLSGSE-ESTPSI----IYH------------------CALRGLERLLLSE- -----------------------------QLSRLDAESLVKLSVDRVNVHS-PHRAMAAL GLMLTCMYT-------------------------------------GKEKVSP-GRTSDP NPAA-PDSESVI----VAMERVS-----VLFDRIR--------------KGFPCEARVVA RILPQFLDDF---------FPPQD-------IMNKVIGEFLSN-QQPYPQFMATVVYKVF QTLHSTGQSSMV-RDWVMLSLSNFTQRTPVAMATWSLSCFFVSASTSPWVAAILPHVIS- ------------------------------------------------------------ ---RMGKLE-QVDVNLFCLVATDFYRHQIEEE------LDRRAFQSVFEVVAA---PGSP YHRLLTCLRNVHKVTTC-------------------- Rattus_norvegicus -----MATLEK------------------------------------------------- ---------------------------------LMKAFESLKSF------------QQQQ QQQQPPPQAPPPPPPPPPQPPQPPPQGQ-P----------PPPPPLPGP--AEEPLHRPK KELSATKKDRVNH-CLTICENIVAQSLRNSPE-FQKLLGIAMELFLLCSDDAESDVRMVA DECLNKVIKA-----LMDSNLPRLQLELYKEIKKNGAPRSLRAALWRFAELAHLVRPQKC -RPYLVNLLPCLTRTSKRPEESV-QETLAAAVPKIMASFGNFANDNE-IKVLLKAFIANL KSSSPTVRRTAAGSAVSICQHSRRT-QYFYNWLLNVLLGLLVPMEED-HPTLLILGVLLT LRCLVPLLQQQV-KDTSLKGSFG----------VTRKEMEVSP-SAEQLVQVYELTLHHT QHQ---DHNVVTGALELLQQLFRTPPP-----------ELLQALTTPGGLGQ-------- -------------LTLVREEAGGRGRSGSIVELLAGGGSSCSPVLSRKQKGKVLLGEEEA LEDDSESRSDVSSSAFAASVKSEIGGELAASSSG----VSTPG--------SVGHDIITE QPR-SQHTLQA-DSVDLSGCD-----------LTSAATDGDEEDILSHSSSQFSAVPSDP AMDLNDG-TQ--------------ASSPISDSSQTTTEGPDSAVTPSDSSEI-------- -------------------------------------------------------VLDGA DSQYLGVQIGQPQEED-EEEAAGVL----------------------------------- --SGEVSDVFRNSSLALQQAHLLERM-------------------GHSRQPSDSSVDKFV SKDEVAEAGDPESKPCRIKGDI----GQPNDD---DSAPLVHCV---------------- -------RLLSASF-LLTGEKKALVPDRDVRVSVKALALSCIGA-AVALHPESFFSKLYK VP---------------------------------------------------------- ------------------------------------------------------------ -----------------------------LSTM-ESTEEQ-----YVSDI---LNYIDHG DPQVRGATAILCGTLVYSI----------------------------------------- --------------------------------------------LSRSRLRVGDWLGTIR ALTGNT-F---SLVDCIPLLQKTLKDE-SSVTCKLACTAVRHCVLSLC------------ -SSSYSDLGLQ--------------------------------------------LLIDM LPLKNSSYWLVRTELLETLAEIDFRLVSFLEAK----AESLHRGAHHYTG---------- -----------FLKLQERVLNNVVIYLLGDEDPRVRHVAATTLTRLVPK----------- --------------LF--------------YKCDQG---------QADPVVAVARDQSSV Y-----LKLLMHETQPPSHFSVSTI-TRIYRGYSLLPSVTDV-TMEN-NLSRVVAAVSHE LITSTTRALTFGCCEALCVLSAAFPVCTWSLGWHC-G----------------------- VPPLSAS----------DESRKSCTV------GMASMILTL--LSSA-------WFPLDL SAHQDA----LILAGNLLAASAPKSLR--SSWASEEEGSSAAT-------RQEEIWPALG DRTLVPMVEQLFSHLLKVINICAHVLDDV-TPGPAI--------------KAALPSLTNP P----SLSPIR-------RKGKEKEPGEQTSTPMSPK----K---GGEASTASRQSDTSG PVTA--SKSSSLGSFYHLPSYLRLHDVLKATHANYKVTLDLQNSTEKFGGFLRSALDVLS QILE--LATLQDIGKCVEEVLGYLKSCFSREPMMATVCVQQLLKTLFGTNLASQFDGLSS N--PS---KSQCRAQRLGSSS--VRP-------GLYHYCFMAPYTHFTQALADASLRNMV -QADQEHDASGWFDVLQKVSAQLKTNLTSVTKN-RADKNAIHNHIRLFEPLVIKALKQYT TTTSVQL-QKQVLDLLAQLVQLRVNYCLLDSDQVFIGFVLKQFEYIEVGQF--------- -RESEAIIPNIFFFLVLLSYER--Y-----HSKQIIGIPKIIQLCDGIMASGRKAVTHAI PALQPIVHDLFVL-------------------------------RG--TNKADAG----- ------------------KELETQKEVVVSMLL-RLIQ---YHQVLEMFILVLQQCHKEN -----------EDKWKR---------LSRQVADIILP----------------MLAKQQM HIDSHEALGVLNTLFEILAPSSL---RPVDMLLRSMF----------------------I TPST----MASVSTVQLWISGILAILRVLISQSTEDIVLSRIQ----------ELSFSPY LISCPVI-NRLRDGDSN-PTLG--------ERSEGKQVKNLPEDTFSRFLLQLVGILLED IV--TKQLKVDMSEQQHT-FYCQELGTLLMCLIHIFKSGMFRRITAAATRLFTSD---GC EGS-FYTLDSLNAR---------VRAMVPTHPALVLLWC-----------------QILL LINHTDHR-WWAEVQQTPKRHSLSCTKSLNPQISA-EEDSGSAAQLGM---CNREIVRRG ALILFCDYVCQNLHDS------EHLTWLIVNHIQDLISLSH------EPPVQDFISAIHR NSAAS----GLFIQAIQ-----SRCENLSTPTTLKKTL-QCLEGIHLSQS---GAVLTLY VD-RLLGTPFRALAR-------MVDTLACRRVEMLLAANLQSSMAQLPEEELNRIQEHLQ NTGLAQRH---QRLYSLLDRFRLSTVQDSLSPL-------------PPVTSHPLDGDGHT SLETVNPDKDWYLQLVRSQ----CWTRSDSAL-------LEGAELVNRIPAED-MSDFMM SS--EFNLSLLAPCL-SLGMSEIANGQK----------------------------SPL- ----FEAARRVTLDRV----TNVVQQLPAVH---------QVFQPFLPTEPTA------- ------------YWSKLNDLFGDTTSYQSLTTLARALAQYLVVLSKVPAPLHLPPEKEGH TVKFVVMTLEALSWHLIHEQIPLSLDLQAGLDCCCLALQ-VPGLW--------------- -------------------GVLSSPEYVTHTCSLIHCV---------------RFILEAI AVQPG------------------DQLLGPESRSHTPRAVR--KEEVDSDIQNL-SHITSA ---CEMVADMVE-----------SLQSVLALGHKRN------------------------ ---------------------STLPSFLTA--VLKNIVVSLARLPLVNSYTRVPPLVW-- --------KLGWSPKPGGDFGTV-------------FPEIPVEFLQEKEVLKEFIYRINT LGWTSRTQFEETWATLLGVLVTQP--------LVMEQEES----PPEEDTERTQIHVLAV QAITSLVLSAMAVPVAGNPAVSCLEQQPRNK-PLKALDTRFGRKLSMIRGIVEQEIQEMV S--------QRENTATHHSHQAWDPVP-SLLPAT-TGALISH---------DKLLLQ--- --INSEREPGNMSYKLGQVS----------------IHSVWLG----------NNITPLR EEEWDEE--------------------------EEEEADAPAPTSPPVSPVNSRKHR--- --AGV-------------DIHSCSQFLLELYSRWI--------LPSSAA-RRTPVILISE VVRSLLVVSDLFTERTQFEMMYLTLTELRRVHPSEDE----ILIQYLVPATCKAAAVLGM DK-------TVAEPVSR-----------------------LLES-TLRSTH--------- ---LPSQIGALHGILYVLECDLLDDTVKQ--------LIPVVSDYLLSNLKGIAHCVNI- ------------------------------------------------------------ -------------------HSQ-QHVLVMCATAFYLMENYPLDVG----------PEFSA SVIQMCGVMLSGSE-ESTPSI----IYH------------------CALRGLERLLLSE- -----------------------------QLSRLDTESLVKLSVDRVNVQS-PHRAMAAL GLMLTCMYT-------------------------------------GKEKASP-GRASDP SPAT-PDSESVI----VAMERVS-----VLFDRIR--------------KGFPCEARVVA RILPQFLDDF---------FPPQD-------VMNKVIGEFLSN-QQPYPQFMATVVYKVF QTLHSAGQSSMV-RDWVMLSLSNFTQRTPVAMAMWSLSCFLVSASTSPWVSAILPHVIS- ------------------------------------------------------------ ---RMGKLE-QVDVNLFCLVATDFYRHQIEEE------FDRRAFQSVFEVVAA---PGSP YHRLLACLQNVHKVTAC-------------------- Sus_scrofa -----MATLEK------------------------------------------------- ---------------------------------LMKAFESLKSF----------QQQQQQ QQQQQQQQQQQQLPPPPPQPPQPPPQTQPP--PQPPPPPPPPPPPPPGPAVAEEPLHRPK KELSATKKDRVNH-CLTICENIVAQSLRNSPE-FQKLLGIAMELFLLCSDDAESDVRMVA DECLNKVIKA-----LMDSNLPRLQLELYKEIKKNGAPRSLRAALWRFAELAHLVRPQKC -RPYLVNLLPCLTRTSKRPEESV-QETLAAAVPKIMASFGNFANDNE-IKVLLKAFVANL KSGSPTVRRTAAGAAVSVCQHSRRT-RYFYSWLLSVLLGLLVPVEEE-HGTLLILGVLLT LRYLVPLLQQQV-KDTSLKGSFG----------VTRKEMEVSP-STEQLVQVYELTLHYT QHQ---DHNVVTGALELLQQLLRTPPP-----------ELLQALTSPGGIAQ-------- -------------LTANNDEPRCRSRSGSIVELIAGGGSSCSPVLSRKQKGKVLLGDAAA LEDEPASRSEGSSPALTASVTGELGGELAP-SSG----VSTPGS-ASSAADSVGHDIITE QPR-SQHTLQP-DSVDLSGCD-----------LSSAATDGDEEDILSHSSSQMSAVPSDP AMDLNDG-TQ--------------ASSPVSDSSQTTTEGPDSAVTPSDSSEI-------- -------------------------------------------------------VLDGA DGQYSGLRLGQPQDADADEDAAGLL----------------------------------- --PHGGPDAFRSSPTALQQSHVLKSL-------------------GHSRQPSDSSVDKFV SRDEAAEAGEPENKPCRIKGDI----GQSTDE---DSAPLVHCV---------------- -------RLLSASF-LLTGKRNALVPDRDVRVSVKALALSCVGA-AVALHPESFFSKLYK AP---------------------------------------------------------- ------------------------------------------------------------ -----------------------------LDSV-EYPDEQ-----YVSDI---LSYIHHG DPQVRGATAILCGTLVSSI----------------------------------------- --------------------------------------------LSRSRFHVGDWMGAVR ALTGNA-F---SLVDCIPLLQKTLKDE-SSVTCKLACTAVRLCVAALC------------ -GSSYSQWGLQ--------------------------------------------LITDL LTLRSSSYWLVRTELLETVAEIDFRLVSFLEAK----AENLHRGAHHYTG---------- -----------LLRLQERVLNNVVIYLLGDEDPRVRHVAAASLVRLVPK----------- --------------LF--------------YKCDQG---------QADPVVAVARDQSSV Y-----LKLLMHETQPPSHFSVSTV-TRTYRGYNLLPSVTDV-TLEN-NLSRVTAAVSHE LITSTTRALTFGCCEALCLLSTAFPVCVWSLGWHC-G----------------------- VPPLGAA----------DESRKSCTV------GMATTVLTL--LSSA-------WFPLDL SAHQDA----LILAGNLLAASAPRSLR--SSWTLEEEASPAAT-------RQEEVWPALG DRSLVPMVEQLFSHLLKVLNICAHVLDDV-APGPAV--------------KAALPSLANP P----SLSPIR-------RKGKEKEPGEQASVPVSPK----K---GGEASPAARQSDTSG PVAA--NKSSSLGSFCHLPSYLKLHDVLKATHANYKVTLDLQSGTEKFRGLLCSALDVLS QVLE--VATLQDIGKCVEEILGYLKSCFSREPTMATVCVQQLLKTLFGTNLASQFDGLAS T--PS---KCQGRAQRLGSSS--VRP-------GLYHYCFMAPYTHFTQALADASLRNLV -QAEQDHDASGWFDVLQKVSTQLKTNLTSVTKN-RADKTALHNHIRLFEPLVIKALKQYT TTTSVQL-QKQVLDLLAQLVQLRVNYCLLDSDQVFIGFVLKQFEYIEVGQF--------- -RESEAIIPNIFFFLVLLSYER--Y-----HSKQIIGIPKIIQLCDGIMASGRKAVTHAI PALQPIVHDLFVL-------------------------------RG--TNKADAG----- ------------------KELETQKEVVVSMLL-RLVQ---YHQVLEMLILVLQQCHKES -----------EDKWKR---------LSRQVADVILP----------------MLARQQM HIDSHDALGVLNTLFEVLAPSSL---RPVDMLLRTMF----------------------L TPDS----LAAVSTVQLWVSGILAILRVLISQSTEDIVLSRIQ----------ELSFSPS LISCPMI-IRLRGGNSD-SAPE--------EHSEGRQGKNLPEETFSRFLLQLVGILLED IV--TKRLRVEVSEQQHT-FYCQELGTLLMCLIHIFKSGMFRRVTAAASRLLT-D---GA DGA-FFGLERLNAW---------VRAMVPTHPALVLLWC-----------------QILL LVSHTDYR-WWAEVQQTPRRRSLSSTKSLGPQMSGEDEDSDAASRLGM---CSREIVRRG ALILFCDYVCQNLHDS------EHLTWLIVNHIQDLIHLSH------EPPVQDFISAVHR NAAAS----GLFIQAIQ-----SRCENLSAPTTLKKTL-QCLEGIHLSQS---GAVLTLY VD-KLLRTPFRVLAR-------MVDTLACRRVEMLLAANLQSSMAQLPVEELTRIQEYLQ SSGLAQRH---QRLSSLLDRLRLATAPGSRGPA-------------PRVSSHPLDGDGPL ALETVSPDKDWYLRLVKSQ----CWTRSDSAL-------LEGAELVSRIPPGD-MGAFLM NP--EFNLSLLAPCL-GLGMREISAGQK----------------------------SPL- ----FEAARAATLDRV----TSVVQQLPAVH---------QVFQPFLPTEPAA------- ------------YWSKLDDLFGDAVLYRSLTTLARALAQYLLVLSKLPGPLQLPPEKEAD TVRFVVMTLEALAWHLVHEQIPLSLDLQAGLDCCCLALQ-LPGLW--------------- -------------------SALSSPEMVTHACSLILCV---------------RFILEAI VVQPG------------------DQLLSPERKADTPKAAG--EDEVDSNTQSP-PYLGAA ---CRMVAEMVA-----------SLPSVLALGRERS------------------------ ---------------------SRTPAFLAP--VLRNVIVSLARLPLVNSYTRVPPLVW-- --------KLGWSPRPGGDFGTA-------------FPEIPVEFLQEKEVFREFIFRINT LGWTSRTQFEETWATLLGVLVTQP--------LVMEQEEN----PPEEDTERTQIHVLAV QAITSLVLSAMTVPVAGNPAVSCLEQQPRNK-PLKALDTRFGRKLSVIRGVVEQEVQAMV S--------KRENVATHHLYQAWDPVP-SLSPAT-TGALISH---------DRLLLQ--- --VNPERELGDTGYQLGQVS----------------IHSVWLG----------NSITPLR EEEWDEE--------------------------EEEEADVPVP-SPPTSPLNSRKHR--- --AGV-------------DIHSCSQFLLELYSRWI--------LPSSAA-RRTPVILISE VVRSLLVVSDLFTERSQFEMMYLTLTELRRAHPPEDE----ILLQYLVPATCKAAAVLGM DK-------AVAEPVSR-----------------------LLES-TLRSSH--------- ---LPSRIGALHGALYVLECDLLDDTAKQ--------LIPAISDYLLSNLRGVAHCVNV- ------------------------------------------------------------ -------------------HSQ-QHVLVMCATAFYLIENYPLDVG----------PEFSA SVIQMCGVMLSGSE-ESTPSI----VYH------------------CVLRGLERLLLSE- -----------------------------QLSRLDAESLVKLSVDRVNAHS-PHRAMAAL GLMLTCMYT-------------------------------------GKEKISP-GRSSDP SPAA-PDSESVI----VAMERVS-----VLFDRIR--------------KGFPCEARVVA RILPQFLDDF---------FPPQD-------VMNKVIGEFLSN-QQPYPQFMATVVYQVF QTLHSTGQSSMV-RDWVMLSLSNFTQRTPVAMAVWSLSCFFVSASTSPWVSAILPHVVS- ------------------------------------------------------------ ---RMGKLE-QVDVNLFCLVATDFYRHQIEEE------LDRRAFQSVFEVVAV---PGNP YHRLLTCLQDVHRVAAC-------------------- Taeniopygia_guttata -----MATMEK------------------------------------------------- ---------------------------------LTKAFESLRSF---------------Q QQQGP-------------------------------------------AALPEEPLQRPK KELSATKKDRVNH-CLTICENIVAQSLRNSPE-FQKLLGIAMELFLLCSEDAESDVRMVA DECLNKVIKA-----LMDSNLPRLQLELYKEIKKNGASRSLRAALWRFAELAHLVRPQKC -RPYLVNLLPCLTRISKRPEESV-QETLAAAIPKIMAAFGNFANDNE-IKVLLKAFIANL KSSSPTIRRTAAGSAVSICQHSRRT-QYFYAWLLNVLL---------------------- ------------------------------------------------VCSQFDFA---- ------------------------------------------------------------ -----------------------------------------------------YLGQ--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------VLEGA EGQYSGMQIGQLQDEE-DE-ATNIL----------------------------------- --QDDSSESFRNSSLALQQSHLLKTT-------------------SHSRQPSDSSVDRFT SKEEAADAGDHENKPSRVKGDI----GHYTDR---DCAPLVHCV---------------- -------RLLSASF-LLTGDKGALVPDRDVRVSVKALAVSCVGA-AVALHPESFFSKLYK TP---------------------------------------------------------- ------------------------------------------------------------ -----------------------------LEAMGEEYEEQ-----YVSDI---LNYIDHG DPQIRGATAILCGTIVNSI----------------------------------------- --------------------------------------------LIKSRFDVEKWLINVR SSTGNL-F---SLIDCIPLLQKTLKDE-SSVTCKLACTAVRHCIMSLC------------ -SSSYSELGLQ--------------------------------------------LIVDL LALKNSSYWLVRTELLETLAEVDFRLVNFLEGK----TESLHRGIHHYTG---------- -----------LLKLQERVLENVVISLLGDEDPRVRHVAAACLMRLVPK----------- --------------LF--------------YNCDQG---------QADPVVAVARDQSSV Y-----LKLLMHETQPPSHFAVSTI-TRAYRGYNMLQSPTDV-TMEN-NLSRVIAAISHA LTISTTRALTFGCCEALCLLSTTFPVCTWSVGWHC-G----------------------- VSQSSSS----------DEAQKGCTI------GMAGLVLSL--LSSA-------WFPLDL SAHQDA----LILTGNLLAASAPKCLK--NPWSAEEDINQGAA-------KQEEPWPALS DRALVTLVEQLFSHLLKVINICAHVMDDV-APGPAV--------------KAALPSLTNP P----SLSPIR-------RKGKERESVEQASVPMSPK----K---SGEASPASRQTDATG PVPT--SKSSSVGSFYHLPSYLKLYDVLKATHANYKVTLDLQNTNEKFGCFLRSALDVLS QILE--LATLQDIGKCVEEILGYLKSCFNREPTMATVCVQQLLKTLFGTNLASQYDGLSS N--PS---KAQGKAQRLGSSN--LRP-------GLYHYCFMAPYTHFTQALADASLRNMV -QAEQEHDASGWFDVLQKVSTQLKTSISSAAKH-RADKNAIHNHIRLFEPLVIKALKQYT TTTSVQL-QRQVLDLLAQLVQLRVNYCLLDSDQVFIGFVLKQFEYIEVGQF--------- -RESEAIIPNIFFFLVLLSYER--Y-----HSKQIIGIPKIIQLCDGIMASGRKAVTHAI PALQPIVHDLFVL-------------------------------RG--TNKADAG----- ------------------KELETQKEVVVSMLL-RLIQ---YHQVLEMFILVLQQCHKEN -----------EDKWKR---------LSRQIADIILP----------------MLAKQQM HIDSHDALGVLNTLFEILAPSSL---RPVDMLLRSMF----------------------V TPKT----MASVSTVQLWISGILAILRVLISQSTEDIVLSRIQ----------ELSFSPY LISCQAI-NRLRCGENNLSTPE--------ERTEVKQVKYPPEETFSRFLLQLVGILLED IV--TKQLKVDMNEQQHT-FYCQELGTLLMCLIHIFKSGMFRRITAAATRLFTGD---GS DGS-FYTLESLSDL---------VQSMIPTHPSLVLLWC-----------------HILL LVNYTNYN-WWSEVHQTPKRHSLSTTKLLSPHVSGDSDESNLESKRGM---CNREIVRRG ALILFCDYVCQNLHDS------EHLTWLIVNHVQDLINLSH------EPPVQDFISAVHR NSAAS----GLFIQAIQ-----SRCENLAAPTTLKKTL-QCLEGIHLSQS---GAVLTLY VD-KLLCTPFRVLAR-------MVDTLACRRVEMLLAATLQNSITQLPVEELDRIQEYLQ NSGLAARH---QRLYSLLDRFRLMVAPDTTSPS-------------PLVTSHPLDGEDQP PLENVVLDKDWYVSLVRSQ----CYVRSDSAL-------LEGAELVNRIPQPD-LNSFMT SK--EFNLSLLAPCL-SLGMNELSRDQK----------------------------SSL- ----FETVRRVTLDHV----SSAVQNLPANH---------QVFQPLLPTEPSA------- ------------YWKKLSDIFGDEVMYQSMMTLCRALAQYLLLLSKLPAGLRVPPDKEGD ILKFVVMSVEALSWHLVHDQIPLSVDLQAGLDCCCLTLQ-QPSLW--------------- -------------------NLLSSATHVTYACSLINCI---------------RFIIEAV AVEPG------------------NQLLSPERK-NTSKPLS--EGEIDLNVQKT-KHVIAA ---CEMIAEMVE-----------CLQTVLSLGHRRN------------------------ ---------------------SSIPAFLTP--VLKNIIISLARLPLVNSYTRVPPLVW-- --------KLGWSPKPSGDFGTV-------------FPEIPVEFLQEKEIFKEFIYRINT LGWISRTQFEETWATLLGVLVTQP--------IVMDQEEN----QQEEDTERTQINVLAV QAITSLVLSAMTIPVAGNPAVSCLEQQPRNK-ALKALDTRFGRKLSVIRGIVEQEIQAMV S--------KRDNIATHHLYQAWDPVP-SLSPAT-TGALISH---------EKLLLQ--- --INTEREIGDMDYKLGQVS----------------IHSIWLG----------NNITPLR EEEWGED--------------------------EEDENDVPAPSSPPTSPINTRKHR--- --AGV-------------DIHSCSQFLLELYSQWI--------LPSNPS-KRTPVILISE VVRSLLAVSDLFTERNQFEMMYTTLTELRKVHPSEDE----ILVQYLIPATCKAAAVLGM DK-------AVAEPVSR-----------------------LLES-TLRSTH--------- ---MPSRIGALHGILYILECDLLDETAKQ--------LIPIISEYLLSNLKGVAHCVNI- ------------------------------------------------------------ -------------------HNQ-EHILVMCAAAFYLIENYPLDVG----------PEFSA GIIQMCGVMVSGSD-ESTPSI----IYH------------------CVLRGLERLLLSE- -----------------------------QLSRLDSESLVKLSVDRVNVQS-PHRAMAAL GLMLTCMYT-------------------------------------GKEKISP-SRIPDA NPGA-PDSESVI----VAMERVS-----VLFDRIR--------------KGFPFEARVVA RILPQFLDDF---------FPPQD-------VMNKVIGEFLSN-QQPYPQFMATVVYKVF QTLHSTGQSSMV-RDWVMLSLSNFTQRTPVAMAMWSLSCFFVSASTSQWISAILPHIIS- ------------------------------------------------------------ ---RMGKSE-QVDVNIFCLVAIDFYRHQIDEE------LDRRAFQSVFEVVAS---PGTP YHRLLTCLQNVHKVTAC-------------------- Takifugu_rubripes -----MATMEK------------------------------------------------- ---------------------------------LMKAFESLKSF---------------Q QQQ--------------------------------------------GPPTAEEIVQRQK KEQATTKKDRVSH-CLTICENIVAQSLRTSPE-FQKLLGIAMEMFLLCSDDSESDVRMVA DECLNRIIKA-----LMDSNLPRLQLELYKEIKKNGASRSLRAALWRFAELAHLIRPQKC -RPYLVNLLPCLTRITKRQEETI-QETLAAAMPKIMAALGHFANDGE-IKMLLKSFVANL KSSSPTIRRTAASSAVSVCQHSRRT-SYFYTWLLNVLLGLLVPVDEE-HHSHLILGVLLT LRYLMPLLQQQV-NTISLKGSFG----------VMQKEADVQP-APEQLLQVYELTLHYT QHW---DHNVVTAALELLQQTLRTPPP-----------ELLHVLITAGSIQH-------- -------------ASVFRQDIESRARSGSILELI----------------GKMLSGEEDA LEDDPE-KTDVTTGYFTA-VGADNSSAA-------------------------QVDIITQ QPRSSQHTIQPGDSVDLSASSEQGGRGGGASASDTPESPNDEEDMLSRSSSCGANITPET VEDATPE-NPAQEGRPVGGSGAYDHSLPPSDSSQTTTEGPDSAVTPSDVAEL-------- -------------------------------------------------------VLDGS ESQYSGMQIGTLQDEE-DEGTATSS----------------------------------- --QEDPPDPFLRSALALSKPHLFESR-------------------GHNRQGSDSSVDRFI PKDEPPEP-EPDNKMSRIKGAI----GHYTDR---GAEPVVHCV---------------- -------RLLSASF-LLTGQKNGLTPDRDVRVSVKALAVSCVGA-AAALHPEAFFNSLYL EP---------------------------------------------------------- ------------------------------------------------------------ -----------------------------LDGL-RAEEQQ-----YISDV---LGFIDHG DPQIRGATAILCAAIIQAA----------------------------------------- --------------------------------------------LSKMRYNIHSWLASVQ SKTGNP-L---SLVDLVPLLQKALKDE-SSVTCKMACSAVRHCIMSLC------------ -GSTLSELGLR--------------------------------------------LVVDL FALKDSSYWLVRTELLETLAEMDFRLVNFLERK----SEALHKGEHHYTG---------- -----------RLRLQERVLNDVVIQLLGDDDPRVRHVAASAVSRLVSR----------- --------------LF--------------FDCDQG---------QADPVVAIARDQSSV Y-----LQLLMHETQPPSQLTVSTI-TRTYRGFNLSNNVADV-TVEN-NLSRVVTAVSHA FTSSTSRALTFGCCEALCLLAVHFPICTWTTGWHC-GHISSQSSFSSRVG--RSRGRTLS VSQSGSTPASSTTSSAVDPERRTLTV------GTANMVLSL--LSSA-------WFPLDL SAHQDA----LLLCGNLLAAVAPKCLR--NPWAGEDDSSSSSTNTSGGTHKMEEPWAALS DRAFVAMVEQLFSHLLKVLNICAHVLDDT-PPGPPV--------------KATLPSLTNT P----SLSPIR-------RKGKDKDAVDSSSAPLSPK----K---GNEAN-TGRPTESTG STAV--HKSTTLGSFYHLPPYLKLYDVLKATHANFKVMLDLHSNQEKFGSFLRAALDVLS QLLE--LATLNDINKCVEEILGYLKSCFSREPTMATVCVQQLLKTLFGTNLASQYEGFLS G--PS---RSQGKALRLGSSS--LRP-------GLYHYCFMAPYTHFTQALADASLRNMV -QAEHEQDTSGWFDVMQKTSNQLRSNIANAARH-RGDKNAIHNHIRLFEPLVIKALKQYT TSTSVAL-QRQVLDLLAQLVQLRVNYCLLDSDQVFIGFVLKQFEYIEVGQF--------- -RDSEAIIPNIFFFLVLLSYER--Y-----HSKQIISIPKIIQLCDGIMASGRKAVTHAI PALQPIVHDLFVL-------------------------------RG--SNKADAG----- ------------------KELETQKEVVVSMLL-RLVQ---YHQVLEMFILVLQQCHKEN -----------EDKWKR---------LSRQIADVILP----------------MIAKQQM HLDSPEALGVLNTLFETVAPSSL---RPVDMLLKSMF----------------------T TPVT----MASVATVQLWVSGILAVLRVLVSQSTEDIVLSRIH----------ELSLSPH LLSCHTI-KRLQQPNLSPSDQPAGDGQQN-QEPNGEAQKSLPEETFARFLIQLVGVLLDD IS--SRHVKVDITEQQHT-FYCQQLGTLLMCLIHVFKSGMFRRITVAASRLLKGESGSGH SGIEFYPLEGLNSM---------VHCLITTHPSLVLLWC-----------------QVLL IIDYTNYS-WWTEVHQTPKGHSLSCTKLLSPHSSGEGEEKP-ETRLAM---INREIVRRG ALILFCDYVCQNLHDS------EHLTWLIVNHVRDLIDLSH------EPPVQDFISAVHR NSAAS----GLFIQAIQ-----SRCDNLNSPTMLKKTL-QCLEGIHLSQS---GSLLMLY VD-KLLSTPFRVLAR-------MVDTLACRRVEMLLAETLQNSVAQLPLEELHRIQEYLQ TSGLAQRH---QRFYSLLDRFR-ATVSDTSSPS-------------TPVTSHPLDGDPPP APELVIADKEWYVALVKSQ----CCLHGDVSL-------LETTELLTKLPPAD-LLSVMS CK-QEFNLSLLCPCL-SLGVQRLLRGQG----------------------------SLL- ----LETALQVTLEQL----AGATGLLPVPH------------HSFIPTSHPQ------- -----------SHWKQLAEVYGDPGFYSRVLSLCRALSQYLLTVKQLPSSLRIPSDKEHL ITTFTCAATEVVVWHLLQDQLPLSVDLQWALSCLCLALQ-QPCVW--------------- -------------------NKLSTPEYNTHTCSLIYCL---------------HHIILAV AVSPG------------------DQLLHPERKKTKALRHSDDEDQVDSVHDNH-TLEWQA ---CEIMAELVE-----------GLQSVLSLGHHRN------------------------ ---------------------TAFPAFLTP--TLRNIIISLSRLPLVNSHTRVPPLVW-- --------KLGWSPQPGGEFGTT-------------LPEIPVDFLQEKDVFREFLYRINT LGWSNRTQFEETWATLLGVLVTQP--------ITMDQEEE---TQQEEDLERTQLNVLAV QAITSLVLSAMTLPTAGNPAVSCLEQQPRNK-SLKALETRFGRKLAVIRGEVEREIQALV S--------KRDNVHTYHPYHAWDPVP-SLSAASPAGTLISH---------EKLLLQ--- --INTERELGNMDYKLGQVS----------------IHSVWLG----------NNITPLR EEEWGED--------------------------EDDEADPPAPTSPPLSPINSRKHR--- --AGV-------------DIHSCSQFLLELYSQWV--------IPGSPSNRKTPTILISE VVRSLLAVSDLFTERNQFDMMFSTLMELQKLHPPEDE----ILNQYLVPAICKAAAVLGM DK-------AIAEPVCR-----------------------LLET-TLRSTH--------- ---LPSRMGALHGVLYVLECDLLDDTAKQ--------LIPTVSEYLLSNLRAIAHCVNL- ------------------------------------------------------------ -------------------HNQ-QHVLVMCAVAFYMMENYPLDVG----------TEFMA GIIQLCGVMVSASE-DSTPSI----IYH------------------CVLRGLERLLLSE- -----------------------------QLSRVDGEALVKLSVDRVNMPS-PHRAMAAL GLMLTCMYTAVLTSGSDVAGVRGQVESGSAVAEALGVTAGHVGLFSGKEKASPAARSAHS DPQV-PDSESII----VAMERVS-----VLFDRIR--------------KGLPSEARVVA RILPQFLDDF---------FPPQD-------IMNKVIGEFLSN-QQPYPQFMATVVYKVF QTLHATGQSSMV-RDWVLLSLSNFTQRTPVAMAMWSLSCFFVSASTSQWISALLPHVIS- ------------------------------------------------------------ ---RMGSSD-VVDVNLFCLVAMDFYRHQIDEE------LDRRAFQSVFETVAS---PGSP YFQLLACLQSIHQDKSL-------------------- Trichoplax_adhaerens -----MSAADK------------------------------------------------- ---------------------------------LLRAFEALKNY---------------- --------------------------------------------------YEGAPEEDPR KKEVLTTKERIFF-CSSIPELINTPSIKSLPE-FGKLISIAIEILLIACDDSESDVRMIA DEVLNKTIKV-----LMDINIGRVHIELYKEIKKNGTSRSLRAALWRFADLCHLIRPQKC -RTFALNALPRIVRICKRQDDSV-QDTVASALQKICPVFGKFINDSE-VKILIRNFLINI KSSSATARRTAASAVTLLCRHTTKP-NYFFSWLVSELIDILLPLQNVYQQNFLLLGTLLC LRSIVPYLSKPI-KDTVSGGIHG------TIGGIITENADSSPVNIMHLIKMYGIVMACL KHT---NHNVVTAALETLQLILKSPPK-----------SLLSLLLS-------------- ------------------------------------------------------------ ---DPDDTLMINIARI-----------------------------------GSSHEIVPN KSSSNLDQLES------------------------------------------------K ADNVEAS-----------------IDPAISAVENKDSLAPDAVVKGGNNISV-------- -------------------------------------------------------EIDLA DNVAVQLNLNQSSD------ATTTN----------------------------------- --QDSAG----------------------------------------VSQPVTEANEEDS LADDSSDISRPSIEGSDISRIW----DRLVDS---NKAPIVSCI---------------- -------RMLCTSF-LLDGENGQLIPDKIIRVSVKVLSLNCVSQ-ALGFCPQAFIAPLYA QS---------------------------------------------------------- ------------------------------------------------------------ -----------------------------IASYQEGRNDQAFEIYRVRDV---LQYANHS DPKLRGNIALLIGNYIKTS----------------------------------------- --------------------------------------------LIVAGYHYDLWLHSCL SQQFKN-EHEVYLENFVNLLLLLLKDE-SSVVIGMAIQGVKLCLNSLM------------ -KSDESQLSWN--------------------------------------------IIATV LQLKIHPYWLVRVKLLDILTELDFTLLHYWHQS-RANIDFLRSYCSPCT----------- ---------------QQQVVDEVIMLLLGDEDIRVRQATTTTLVKIIPH----------- --------------LF--------------YPIDHP---------KGDYITAAAQQSLVD D-----VNILNYEHDMSKNLSLLTKGSAVTKTDDRHEYVDDI-TLA--NLSRIINSLLAK LHITSSKYFMTGCLHALSILSNNYPVDKYSSAWGY-------HRSKPKGDLSANTNNVSR QNSFGSL----------DDISGSNGS------GPLPLMVSL--LTSS-------WVTFDL QTHNDV----LILACNLLVGASFNSIL-----TSDGENGKFEI---------TESWPALS DFLLVPLANQLFAHISRLLNIFTHVIDDL-PTTIPQTQKAKEFLREKSGSIAGLTASASA GSLAAVVSPKK--------RFSFRNRGESGAAVNDKK----------ELTPSNDTSDFTS TRSGRIADNGIVGQFVNVAHYFKLYEELRNVQSSYQSSLATNESEDKFANLLKTTLTSFS KILE--VATLNETGRYVEEFVNYMQACIKRESAATLRCVQQFIRCLFSINAATNPWQIPV N-------VCRNRYTNKAAKD--IFT-------GFHQIYSELPLKQF--AIKMIGIKNSQ DDFQLEEDA---------VTIKSHSRLPASETGGRADNKRPVQLIRIFEPLVIHALKQYT FTSSVDL-QQQILHLLAQLIKIRVNYSLLDADQSFVNFILRQFELIEAGQM--------- -KESENIIPSIFQFLILLSYER--M-----NLEPIVGIPRILQLSDGIMASGQLAPAHVI PAFRPVVFDLFNV-------------------------------RSLLKPKGEEG----- ------------------KQLDAQREVVIATLM-KLMD---HHETVELCLVILSSCRDE- -----------ENRWKR---------ISRQMVDFLLP----------------LLTKLQV NVDSIHALHVLHRFFEMVMPISL---RPIDMLVKAFF----------------------- TPAN----MESEVKVHRWLASILIIFHIFLLRADEDTILGRIE----------EMHIDDR QFTL--------------------------SNEDLERSNYNAVDVLTQFIFYVIKNAIGK LV---ESITTPSNEESKYAFLGAEIHLLFLYLKYIIKKAVYRKFTQQAKSLIKNY---QQ EGYGNTIIGQINSL---------ILDLRQSMPRLVLDWC-----------------ELLL QLEFTDKG-WWEQLLLRGEYVSKIALRAVNKLPS-----------------CSHEVIRRG IILLLSDSLQSYYQGPTFK---QILPWFISNYALNIVELSF------EPPAINLLNNING DVELS----GIFLQGVADGLKFSMINLLSKPSFGRKLV-RCLSDIHDSLT---GSLISLI VT-KLLDTHHRCIGR-------LFETLACNRLDFLLTESVEDCQQQLADGKADVLTQFLK DTFKLNRH---LRLKSLIIRVLNHVTINADEIS-------------QLSRQCSLN----- --PTIQVDKVWFLDMIKHR----CFQDKNSINAS-----RKYSLLLRNLPLSD-AVEILN SH--DFDISLLEDCI-TVCLAEFQRSKSDDAEVSGSNGHNDKSQHQLDNGSYQHEPSKF- ----FLECQKVLMGRI----TDQLNMILTEQKNRDDYQREQAAQPQNIDLSSADHDTVET KTSATQFSSLIEFKNIIRDFQ----RVKDINSLTKCLTLVLESEVDLTTDYHLPDEFCEA AARFALLSL-GVSCRMITELTYCYEELYSALSCASVALF-SKKYV--------------- -------------------SIYSNPDYHRVICQGVQFV---------------YDLIISI GLSPG------------------SVLVPSNLSTDLIQQSI--NNDHDIMIFNA------- ---CDKLSQLLH-----------SHRTIFSYSASHR------------------------ -------------------SVFQIPQFLIG--PCISVLLGLARLPLFNSYCCVPLLAW-- --------KMGWLADNQYHPSEP-------------LPPLSPDYLCEKDILEDFVFRINL LGWTSRQQFEEIWVALLGVLGT----------SIPENASN------DEISELNHSNCIAV EGLTSLLLHTSLIPIAGRPNRCIYLHSSRHK-PLPFMNSVIGKKLEKVRGIVEKSIEKFS I--------RRTAGCRSVPINYYNNMG-CMQSTMTSMSKKSHFWLRSNHNSSRMLYN--- --SNTERDISCLEYVLGQVP----------------VCVLRMQ----------VSETDNK DDAYSRA-----------------------TIFEED------------------------ --IGL-------------DIHSCLQFLLELFERWL--------TPQTS--QNITINLKRE AAKSVLVLSDIFVNREHFQWMYDIFMELYKYHPAEDD----VMMQYIVIGICKAVSVLGL DG-------QSVDKICR-----------------------VIEF-SLKSSY--------- ---LSLQICGLFGVLYILEPHPMSSLTA---------FLDPLINYLTTKLSEVQLMSFG- ------------------------------------------------------------ -------------------TSY-QHTLVMLSAAFFIIEHYVDDIKD---------TNFFQ LVLQIVVTMISASD-EVTPPV----IYH------------------AIMRGLERIILSF- -----------------------------TLTPDESDMIIKLSIDRLSMPS-PERALSAL GLLLTCMYA-------------------------------------GKIE-------SEA NPGQELDAMANV----HTIERVT-----ILFDRIR--------------KGLPSEATVVA HILPSVLEDF---------FSPQE-------IMNKVIGEFLSS-QQPHPQLMAEVLFKVF ENLQRQSQQTAV-TKWVMLSIGSFTQRTPLAMAVWGLNCLLISASTNYWIRSLLPYVIS- ------------------------------------------------------------ ---RIGKLE-QVDKQIFYTTALDFFVNKDLDQ------TQKRTFLSTFASSVS---PYSD LNR--YCQQYISNQ----------------------- Xenopus_tropicalis -----MATMEK------------------------------------------------- ---------------------------------LMRAFESLKSF---------------Q QQQV--------------------------------------------PVVPEEPAPKAK KDPSTNKKDRVNH-CLTICENIVAQSLRNSPE-FQKLLGIAMELFLLCSDDAESDVRMVA DECLNKVVKA-----LMDSNLPRLQLELYKEIKKNGAPRSLRAALWRFAELAHLVRPQKC -RPYLVNLLPCLTRISKRHEESV-QETLAAAIPKIMAAFGNFANDNE-IKVLLKAFIANL KSSSPAIRRTAAGSAVSICLHSRRT-QYFYTWLLNVLLGLLIPVEDE-HPTLLILGVLLT LRYLMPLLQQQV-KDTSLKGSFG----------VTQKEADISP-SAEQLIQIYELTLHYT QHR---DHNVVTGALELLQQIFRTPPL-----------DLLHVLTTPGSIEQ-------- -------------VSVCRDEPYSRSRSGSIVELIAGGSSTCSPVIARKQKGKIHLGEEEG LDDDLEGKSDAPATPFAAT-KNEVPSDVTNLSS------TAPG----ANLEGASHDIITE QPR-SQHTLQS-DSVDISSSD-----------LASTVTEGDEEDILSHSSSQISTVQSDT NMELNEGTTQ--------------ASSPVSDSSQTTTEGPDSAVTPSDSSEI-------- -------------------------------------------------------VLDAA ESQYSGMQIGQLQDEE-DE-GAILH----------------------------------- --QEEAGEHFGSSSLGLNQTHLLKTM-------------------GHSRQSSDSSVERFV PKEEPVDPGDLENKPSRIKGDI----GHYMDK---DAAPLIHCV---------------- -------RLLSASF-LLTGQKSVLVPDRDVRVSVKALAVSCVGA-AVALLPESFFSKLYK LP---------------------------------------------------------- ------------------------------------------------------------ -----------------------------TETT-ESQEIQ-----YVSDI---LNYINHG DPQVRGATAILSGTIVFSV----------------------------------------- --------------------------------------------LSKAHFEAETWISKVK ANTGNT-F---SVQDCIPLLQKSLKDE-SSVTCKLACMAVRHCIMTLC------------ -CSTYSELGLQ--------------------------------------------LIIDL LTLKNSSYWLVRTELLETLAEIDFRLVNFMEAR----TENLHRGLHYYTG---------- -----------LLHLQDRVLNNVIISLLGDDDARVRHVAAASLARLVPK----------- --------------LF--------------YNCDQV---------QADPVVAAARDQSSI Y-----LKLLMHETQPPSHFAVSTI-TRIYRGYNIQQSPTDI-SMEN-NISKVITAVSHA LTTSTTRALTFGCCEALCLLSITYPVCTWSIGWHC-GYVTSTSAQTSRIQVYKNRGRSFS ISQQSPS----------EEPRKSCTA------GMSSMILSL--LSSA-------WFPLDL SAHQDA----LVLVGNLLAATAPKSLK--NPWTSEEETSQGAN-------KQEEPWPALG DRAVVGMVDQLFIHLLKAINICAHVIDDI-TPGPVV--------------KATLPSLTNP P----SLSPIR-------RKGKERDTAEQAAVPLSPK----K---SGEATPASRQTEASG PAQT--SK--SIGSFYHLPSYLKLYDVLKATYANYKVSLDLQNNNEKFGGFLRSALDVLS QILE--LATLTDIAKCVEEILGYLKSCFSREPVMATVCVQQLLKTLFGTNLASQFEAMSS N--PS---KCQGKAQRLGSSN--LRP-------GLYHYCFMAPYTHFTQALADASLRNMV -QADQEQDTSGWFDVLQKVSSQLKNSISNVTKH-RTDKNAIHNHIRLFEPLVIKALKQYT TTTSVQL-QRQVLDLLAQLVQLRVNYCLLDSDQVFIGFVLKQFEYIEVGQF--------- -RESEAIIPNVFFFLVLLSYER--Y-----HSKQIIGIPKIIQLCDGIMASGRKAVTHAI PALQPIVHDLFVL-------------------------------RG--ANKADAG----- ------------------KELETQKEVVVSMLL-RLIQ---YHQVLEMFILVLQQCHKEN -----------EDKWKR---------LSRQIADVILP----------------MLSKQQM HIDSHDALGVINTLFETLAPSAL---RPVDMLLRSMF----------------------V VPCT----MASVSTVQLWISGILAILRVLISQSTEDIVLSRIQ----------ELSLSPK LICCQNI-MNLREGDNP-LPPE--------VYPEQSENKPAPEETFSRFLLQLVGILLED IV--YKELKVDLSEQQHT-FYCQQLGTLLMCLIHIFKSGTFRRITNAAMRLFKGD---GS NGS-FYTLESLNGL---------VESMFPTHPSLVLLWC-----------------QFLL LINYTNYS-WWSEVHQTPKRNSLSSTKLLSPHMSTESDDPDLTSKPGI---CNREIVRRG ALILFCDYVCQNLHDS------EHLTWLIVNHVQDLINLSH------EPPVQDFISAIHR NSAAS----GLFIQAIQ-----SRCENLAAPTSLKKTL-QCLEGIHLSQS---GAVLLLY ID-KLLCTPFRVLAR-------MVDTLACRRVEMLLAATPQNSISQLPMEELDRMQEYLQ SSGLAQRH---QRLYSLLDRFRMTVAPDTVSPL-------------PSVTSHPLDGENQA TLETLDPDKEWYVSLVRSQ----CFTHSDSAL-------LEGAELVNKIPAAE-RHSFMT SK--NFNVSLLAPCL-ALGVHQISGEQD----------------------------SSF- ----FKTTLTVIVDLL----SGSVEQLPAGH---------QVLQPLQQVESTA------- ------------YWEKLSLLFGDSSVYCSLVALCRALAQYLVSLPKLPAEFHIQQEKEVD FVKFMVLCVEAISWHLVHEQVPLSMDLQAVIDYCCLTLQ-QPALW--------------- -------------------NLLASSEYVTHACSLIMCV---------------RFILEAV AVEPG------------------DQLLSPERRKNKMSEDS-EEDQVDSSEQKH-VFIKTA ---CEMMAEMVE-----------SLQTILVFGHQKN------------------------ ---------------------RNFSAFLTP--VFRNIIISLARLPLVNSYTRVPPLVW-- --------KLGWAPKWGGEFGTS-------------LPEIPVEFLQEKEVFREFIYCINT LGWTSRTQFEETWATLLGVLVTQP--------MVMDQDEN----QQEEDTERTQINVLAV QAITSLVLSAMTITVAGNPAISFLEQQPRNK-SLKALDTRFGRKLSVVRGIVEEEIQAMV S--------KRDNIATHHSCQAWDPVP-SLSAPT-TGTLINQ---------ERLLLQ--- --INTEREIGNMSYKLGQVS----------------IHSVWLG----------NNITPLR QEELDED--------------------------EEDENENPTPSSPPMSPINSRKHR--- --AGV-------------DIHSCSQFLLELYSQWI--------LPTNTG-KKTPAILISE VVRSLLTVSDLFTERNQFEMMYTALTELQKQHPSEDE----ILNQYLVPAICKAAAVLGM DK-------VIAEPVSR-----------------------IIET-TLRSTH--------- ---MPSRIGALHGILYILECDLLDDTAKQ--------LIPVISDYLLSNLRGIAHCVNL- ------------------------------------------------------------ -------------------HNQ-QHVLVMCATAFYLIENYPLDVG----------PEFTS GIIQMCGVMVSGSE-ESTPSM----VYH------------------CVMRGLERLLLSE- -----------------------------QLSRLDGEALVKLSVDRVNMHS-PHRAMTAL GLMLTCMYT-------------------------------------GKEKISP-GRATEP SPAA-PDSESVI----VAMERVS-----VLFDRIR--------------KGFPFEARVVA RILPQFLDDF---------FPPQD-------VMNKVIGEFLSN-QQPYPQFMATVVYKVF QTLHATGQSSMV-RDWVMLSLSNFTQRTPVAMAMWSLSCFFVSASTSKWISAILPHVIS- ------------------------------------------------------------ ---RMGKSE-PVDVNLFCLVAIDFYKHQIDEE------LDRRSFQSVFELVAS---PGSP YYRLLLCLQNVHKITVF-------------------- ; end; begin mrbayes; prset aamodelpr=mixed; lset rates=Adgamma; mcmc ngen = 1000000 samplefreq=500 printfreq=500 diagnfreq=5000; sump; sumt; end;