<?xml version="1.0" encoding="UTF-8"?>
<sbml level="3" sboTerm="SBO:0000624" version="1" fbc:required="false" xmlns="http://www.sbml.org/sbml/level3/version1/core" xmlns:fbc="http://www.sbml.org/sbml/level3/version1/fbc/version2">
  <model fbc:strict="true" id="model">
    <listOfUnitDefinitions>
      <unitDefinition id="mmol_per_gDW_per_hr">
        <listOfUnits>
          <unit exponent="1" kind="mole" multiplier="1" scale="-3"/>
          <unit exponent="-1" kind="gram" multiplier="1" scale="0"/>
          <unit exponent="-1" kind="second" multiplier="3600" scale="0"/>
        </listOfUnits>
      </unitDefinition>
    </listOfUnitDefinitions>
    <fbc:listOfObjectives fbc:activeObjective="obj">
      <fbc:objective fbc:id="obj" fbc:type="maximize">
        <fbc:listOfFluxObjectives>
          <fbc:fluxObjective fbc:reaction="R_biomass_Mtb_9_60atp" fbc:coefficient="1"/>
        </fbc:listOfFluxObjectives>
      </fbc:objective>
    </fbc:listOfObjectives>
    <listOfParameters>
      <parameter constant="true" id="cobra_default_lb" sboTerm="SBO:0000626" units="mmol_per_gDW_per_hr" value="-1000"/>
      <parameter constant="true" id="cobra_default_ub" sboTerm="SBO:0000626" units="mmol_per_gDW_per_hr" value="1000"/>
      <parameter constant="true" id="cobra_0_bound" sboTerm="SBO:0000626" units="mmol_per_gDW_per_hr" value="0"/>
      <parameter constant="true" id="R_EX_ca2(e)_lower_bound" sboTerm="SBO:0000625" units="mmol_per_gDW_per_hr" value="-1"/>
      <parameter constant="true" id="R_EX_cit(e)_lower_bound" sboTerm="SBO:0000625" units="mmol_per_gDW_per_hr" value="-1"/>
      <parameter constant="true" id="R_EX_cl(e)_lower_bound" sboTerm="SBO:0000625" units="mmol_per_gDW_per_hr" value="-1"/>
      <parameter constant="true" id="R_EX_cu2(e)_lower_bound" sboTerm="SBO:0000625" units="mmol_per_gDW_per_hr" value="-1"/>
      <parameter constant="true" id="R_EX_fe3(e)_lower_bound" sboTerm="SBO:0000625" units="mmol_per_gDW_per_hr" value="-1"/>
      <parameter constant="true" id="R_EX_glc(e)_lower_bound" sboTerm="SBO:0000625" units="mmol_per_gDW_per_hr" value="-1"/>
      <parameter constant="true" id="R_EX_glu_L(e)_lower_bound" sboTerm="SBO:0000625" units="mmol_per_gDW_per_hr" value="-1"/>
      <parameter constant="true" id="R_EX_glyc(e)_lower_bound" sboTerm="SBO:0000625" units="mmol_per_gDW_per_hr" value="-1"/>
      <parameter constant="true" id="R_EX_h2o(e)_lower_bound" sboTerm="SBO:0000625" units="mmol_per_gDW_per_hr" value="-1"/>
      <parameter constant="true" id="R_EX_h(e)_lower_bound" sboTerm="SBO:0000625" units="mmol_per_gDW_per_hr" value="-1"/>
      <parameter constant="true" id="R_EX_k(e)_lower_bound" sboTerm="SBO:0000625" units="mmol_per_gDW_per_hr" value="-1"/>
      <parameter constant="true" id="R_EX_na1(e)_lower_bound" sboTerm="SBO:0000625" units="mmol_per_gDW_per_hr" value="-1"/>
      <parameter constant="true" id="R_EX_nh4(e)_lower_bound" sboTerm="SBO:0000625" units="mmol_per_gDW_per_hr" value="-1"/>
      <parameter constant="true" id="R_EX_o2(e)_lower_bound" sboTerm="SBO:0000625" units="mmol_per_gDW_per_hr" value="-0.98"/>
      <parameter constant="true" id="R_EX_pi(e)_lower_bound" sboTerm="SBO:0000625" units="mmol_per_gDW_per_hr" value="-1"/>
      <parameter constant="true" id="R_EX_so4(e)_lower_bound" sboTerm="SBO:0000625" units="mmol_per_gDW_per_hr" value="-1"/>
      <parameter constant="true" id="R_EX_cholest(e)_lower_bound" sboTerm="SBO:0000625" units="mmol_per_gDW_per_hr" value="-20"/>
    </listOfParameters>
    <listOfCompartments/>
    <listOfSpecies>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_2agpe160[c]" name="2-Acyl-sn-glycero-3-phosphoethanolamine (n-C16:0)" fbc:charge="0" fbc:chemicalFormula="C21H44NO7P1"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_atp[c]" name="ATP" fbc:charge="-4" fbc:chemicalFormula="C10H12N5O13P3"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_hdca[c]" name="Hexadecanoate (n-C16:0)" fbc:charge="-1" fbc:chemicalFormula="C16H31O2"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_amp[c]" name="AMP" fbc:charge="-2" fbc:chemicalFormula="C10H12N5O7P"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_pe160[c]" name="phosphatidylethanolamine (dihexadecanoyl, n-C16:0)" fbc:charge="0" fbc:chemicalFormula="C37H74N1O8P1"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_ppi[c]" name="Diphosphate" fbc:charge="-3" fbc:chemicalFormula="HO7P2"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_2agpe180[c]" name="2-Acyl-sn-glycero-3-phosphoethanolamine (n-C18:0)" fbc:charge="0" fbc:chemicalFormula="C23H48NO7P1"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_ocdca[c]" name="octadecanoate (n-C18:0)" fbc:charge="-1" fbc:chemicalFormula="C18H35O2"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_pe180[c]" name="phosphatidylethanolamine (dioctadecanoyl, n-C18:0)" fbc:charge="0" fbc:chemicalFormula="C41H82N1O8P1"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_h2o[c]" name="H2O" fbc:charge="0" fbc:chemicalFormula="H2O"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_phthr[c]" name="O-Phospho-4-hydroxy-L-threonine" compartment="[" fbc:charge="-2" fbc:chemicalFormula="C4H8NO7P"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_4hthr[c]" name="4-Hydroxy-L-threonine" compartment="[" fbc:charge="0" fbc:chemicalFormula="C4H9NO4"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_pi[c]" name="Phosphate" fbc:charge="-2" fbc:chemicalFormula="HO4P"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_5dglcn[c]" name="5-Dehydro-D-gluconate" fbc:charge="-1" fbc:chemicalFormula="C6H9O7"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_h[c]" name="H+" fbc:charge="1" fbc:chemicalFormula="H"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_nadph[c]" name="Nicotinamide adenine dinucleotide phosphate - reduced" fbc:charge="-4" fbc:chemicalFormula="C21H26N7O17P3"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_glcn[c]" name="D-Gluconate" fbc:charge="-1" fbc:chemicalFormula="C6H11O7"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_nadp[c]" name="Nicotinamide adenine dinucleotide phosphate" fbc:charge="-3" fbc:chemicalFormula="C21H25N7O17P3"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_ACP[c]" name="acyl carrier protein" fbc:charge="-1" fbc:chemicalFormula="C11H21N2O7PRS"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_mocdca[c]" name="10-methylstearic acid" fbc:charge="-1" fbc:chemicalFormula="C19H37O2"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_mstrACP[c]" name="10methyl stearyoyl-ACP" fbc:charge="-1" fbc:chemicalFormula="C30H57N2O8PRS"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_4hbz[c]" name="4-Hydroxybenzoate" fbc:charge="-1" fbc:chemicalFormula="C7H5O3"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_4hbzACP[c]" name="4-hydroxybenzoyl ACP" fbc:charge="-1" fbc:chemicalFormula="C18H25N2O9PRS"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_palmACP[c]" name="Palmitoyl-ACP (n-C16:0ACP)" fbc:charge="-1" fbc:chemicalFormula="C27H51N2O8PRS"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_4abut[c]" name="4-Aminobutanoate" fbc:charge="0" fbc:chemicalFormula="C4H9NO2"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_akg[c]" name="2-Oxoglutarate" fbc:charge="-2" fbc:chemicalFormula="C5H4O5"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_glu-L[c]" name="L-Glutamate" fbc:charge="-1" fbc:chemicalFormula="C5H8NO4"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_sucsal[c]" name="Succinic semialdehyde" fbc:charge="-1" fbc:chemicalFormula="C4H5O3"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_acac[c]" name="Acetoacetate" fbc:charge="-1" fbc:chemicalFormula="C4H5O3"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_accoa[c]" name="Acetyl-CoA" fbc:charge="-4" fbc:chemicalFormula="C23H34N7O17P3S"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_aacoa[c]" name="Acetoacetyl-CoA" fbc:charge="-4" fbc:chemicalFormula="C25H36N7O18P3S"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_ac[c]" name="Acetate" fbc:charge="-1" fbc:chemicalFormula="C2H3O2"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_coa[c]" name="Coenzyme A" fbc:charge="-4" fbc:chemicalFormula="C21H32N7O16P3S"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_acald[c]" name="Acetaldehyde" fbc:charge="0" fbc:chemicalFormula="C2H4O"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_nad[c]" name="Nicotinamide adenine dinucleotide" fbc:charge="-1" fbc:chemicalFormula="C21H26N7O14P2"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_nadh[c]" name="Nicotinamide adenine dinucleotide - reduced" fbc:charge="-2" fbc:chemicalFormula="C21H27N7O14P2"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_adocbip[c]" name="Adenosyl cobinamide phosphate" fbc:charge="-1" fbc:chemicalFormula="C58H83CoN16O14P"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_gtp[c]" name="GTP" fbc:charge="-4" fbc:chemicalFormula="C10H12N5O14P3"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_agdpcbi[c]" name="Adenosine-GDP-cobinamide" fbc:charge="-1" fbc:chemicalFormula="C68H95CoN21O21P2"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_co2[c]" name="CO2" fbc:charge="0" fbc:chemicalFormula="CO2"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_hexccoa[c]" name="Hexacosanoyl-CoA (n-C26:0CoA)" fbc:charge="-4" fbc:chemicalFormula="C47H82N7O17P3S"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_chexccoa[c]" name="carboxy hexacosanoyl-CoA" fbc:charge="-4" fbc:chemicalFormula="C48H81N7O18P3S"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_hco3[c]" name="Bicarbonate" fbc:charge="-1" fbc:chemicalFormula="CHO3"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_adp[c]" name="ADP" fbc:charge="-3" fbc:chemicalFormula="C10H12N5O10P2"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_malcoa[c]" name="Malonyl-CoA" fbc:charge="-5" fbc:chemicalFormula="C24H33N7O19P3S"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_hexc[c]" name="hexacosanoate (n-C26:0)" fbc:charge="-1" fbc:chemicalFormula="C26H51O2"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_acgam6p[c]" name="N-Acetyl-D-glucosamine 6-phosphate" fbc:charge="-2" fbc:chemicalFormula="C8H14NO9P"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_acgam1p[c]" name="N-Acetyl-D-glucosamine 1-phosphate" fbc:charge="-2" fbc:chemicalFormula="C8H14NO9P"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_uacgam[c]" name="UDP-N-acetyl-D-glucosamine" fbc:charge="-2" fbc:chemicalFormula="C17H25N3O17P2"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_udcpp[c]" name="Undecaprenyl phosphate" fbc:charge="-2" fbc:chemicalFormula="C55H89O4P"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_ump[c]" name="UMP" fbc:charge="-2" fbc:chemicalFormula="C9H11N2O9P"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_unaga[c]" name="Undecaprenyl diphospho N-acetyl-glucosamine" fbc:charge="-2" fbc:chemicalFormula="C63H103NO12P2"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_acglu[c]" name="N-Acetyl-L-glutamate" fbc:charge="-2" fbc:chemicalFormula="C7H9NO5"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_acg5p[c]" name="N-Acetyl-L-glutamyl 5-phosphate" fbc:charge="-3" fbc:chemicalFormula="C7H9NO8P"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_2obut[c]" name="2-Oxobutanoate" fbc:charge="-1" fbc:chemicalFormula="C4H5O3"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_pyr[c]" name="Pyruvate" compartment="[" fbc:charge="-1" fbc:chemicalFormula="C3H3O3"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_2ahbut[c]" name="(S)-2-Aceto-2-hydroxybutanoate" fbc:charge="-1" fbc:chemicalFormula="C6H9O4"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_actp[c]" name="Acetyl phosphate" fbc:charge="-2" fbc:chemicalFormula="C2H3O5P"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_alac-S[c]" name="(S)-2-Acetolactate" fbc:charge="-1" fbc:chemicalFormula="C5H7O4"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_acorn[c]" name="N2-Acetyl-L-ornithine" fbc:charge="0" fbc:chemicalFormula="C7H14N2O3"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_orn[c]" name="Ornithine" fbc:charge="1" fbc:chemicalFormula="C5H13N2O2"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_cit[c]" name="Citrate" fbc:charge="-3" fbc:chemicalFormula="C6H5O7"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_icit[c]" name="Isocitrate" fbc:charge="-3" fbc:chemicalFormula="C6H5O7"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_acg5sa[c]" name="N-Acetyl-L-glutamate 5-semialdehyde" fbc:charge="-1" fbc:chemicalFormula="C7H10NO4"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_fmn[c]" name="FMN" fbc:charge="-2" fbc:chemicalFormula="C17H19N4O9P"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_ribflv[c]" name="Riboflavin" fbc:charge="0" fbc:chemicalFormula="C17H20N4O6"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_apoACP[c]" name="apoprotein [acyl carrier protein]" fbc:charge="0" fbc:chemicalFormula="RHO"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_pap[c]" name="Adenosine 3&apos;,5&apos;-bisphosphate" fbc:charge="-4" fbc:chemicalFormula="C10H11N5O10P2"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_ppa[c]" name="Propionate (n-C3:0)" fbc:charge="-1" fbc:chemicalFormula="C3H5O2"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_ppcoa[c]" name="Propanoyl-CoA" fbc:charge="-4" fbc:chemicalFormula="C24H36N7O17P3S"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_acysbmn[c]" name="acetyl-cystine-bimane" fbc:charge="-1" fbc:chemicalFormula="C15H18N3O5S"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_acysbmn[e]" name="acetyl-cystine-bimane" fbc:charge="-1" fbc:chemicalFormula="C15H18N3O5S"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_adn[c]" name="Adenosine" fbc:charge="0" fbc:chemicalFormula="C10H13N5O4"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_ins[c]" name="Inosine" fbc:charge="0" fbc:chemicalFormula="C10H12N4O5"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_nh4[c]" name="Ammonium" fbc:charge="1" fbc:chemicalFormula="H4N"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_4adcho[c]" name="4-amino-4-deoxychorismate" fbc:charge="-1" fbc:chemicalFormula="C10H10NO5"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_4abz[c]" name="4-Aminobenzoate" fbc:charge="-1" fbc:chemicalFormula="C7H6NO2"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_adcobhex[c]" name="adenosyl-cobyric acid" fbc:charge="0" fbc:chemicalFormula="C55H76CoN15O11"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_appl[c]" name="1-Aminopropan-2-ol" fbc:charge="1" fbc:chemicalFormula="C3H10NO"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_adocbi[c]" name="Adenosyl cobinamide" fbc:charge="1" fbc:chemicalFormula="C58H84CoN16O11"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_applp[c]" name="D-1-Aminopropan-2-ol O-phosphate" fbc:charge="-1" fbc:chemicalFormula="C3H9NO4P"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_chor[c]" name="chorismate" compartment="[" fbc:charge="-2" fbc:chemicalFormula="C10H8O6"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_gln-L[c]" name="L-Glutamine" fbc:charge="0" fbc:chemicalFormula="C5H10N2O3"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_adcobdam[c]" name="Adenosyl cobyrinate diamide" fbc:charge="-4" fbc:chemicalFormula="C55H68CoN11O15"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_pppi[c]" name="Inorganic triphosphate" fbc:charge="-4" fbc:chemicalFormula="HO10P3"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_gdp[c]" name="GDP" fbc:charge="-3" fbc:chemicalFormula="C10H12N5O11P2"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_itp[c]" name="ITP" fbc:charge="-4" fbc:chemicalFormula="C10H11N4O14P3"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_idp[c]" name="IDP" fbc:charge="-3" fbc:chemicalFormula="C10H11N4O11P2"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_amet[c]" name="S-Adenosyl-L-methionine" fbc:charge="1" fbc:chemicalFormula="C15H23N6O5S"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_ametam[c]" name="S-Adenosylmethioninamine" fbc:charge="2" fbc:chemicalFormula="C14H24N6O3S"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_camp[c]" name="cAMP" fbc:charge="-1" fbc:chemicalFormula="C10H11N5O6P"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_dgtp[c]" name="dGTP" fbc:charge="-4" fbc:chemicalFormula="C10H12N5O13P3"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_dgdp[c]" name="dGDP" fbc:charge="-3" fbc:chemicalFormula="C10H12N5O10P2"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_rdmbzi[c]" name="N1-(alpha-D-ribosyl)-5,6-dimethylbenzimidazole" fbc:charge="0" fbc:chemicalFormula="C14H18N2O4"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_adocbl[c]" name="Adenosylcobalamin" fbc:charge="0" fbc:chemicalFormula="C72H100CoN18O17P"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_gmp[c]" name="GMP" fbc:charge="-2" fbc:chemicalFormula="C10H12N5O8P"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_ade[c]" name="Adenine" fbc:charge="0" fbc:chemicalFormula="C5H5N5"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_prpp[c]" name="5-Phospho-alpha-D-ribose 1-diphosphate" fbc:charge="-5" fbc:chemicalFormula="C5H8O14P3"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_aps[c]" name="Adenosine 5&apos;-phosphosulfate" fbc:charge="-2" fbc:chemicalFormula="C10H12N5O10PS"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_paps[c]" name="3&apos;-Phosphoadenylyl sulfate" fbc:charge="-4" fbc:chemicalFormula="C10H11N5O13P2S"/>
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      <fbc:geneProduct fbc:id="G_Rv0489" fbc:label="Rv0489" fbc:name="Rv0489"/>
      <fbc:geneProduct fbc:id="G_Rv3068c" fbc:label="Rv3068c" fbc:name="Rv3068c"/>
      <fbc:geneProduct fbc:id="G_Rv1822" fbc:label="Rv1822" fbc:name="Rv1822"/>
      <fbc:geneProduct fbc:id="G_Rv2746c" fbc:label="Rv2746c" fbc:name="Rv2746c"/>
      <fbc:geneProduct fbc:id="G_Rv0820" fbc:label="Rv0820" fbc:name="Rv0820"/>
      <fbc:geneProduct fbc:id="G_Rv0936" fbc:label="Rv0936" fbc:name="Rv0936"/>
      <fbc:geneProduct fbc:id="G_Rv2281" fbc:label="Rv2281" fbc:name="Rv2281"/>
      <fbc:geneProduct fbc:id="G_Rv0545c" fbc:label="Rv0545c" fbc:name="Rv0545c"/>
      <fbc:geneProduct fbc:id="G_Rv3308" fbc:label="Rv3308" fbc:name="Rv3308"/>
      <fbc:geneProduct fbc:id="G_Rv1092c" fbc:label="Rv1092c" fbc:name="Rv1092c"/>
      <fbc:geneProduct fbc:id="G_Rv3628" fbc:label="Rv3628" fbc:name="Rv3628"/>
      <fbc:geneProduct fbc:id="G_Rv0512" fbc:label="Rv0512" fbc:name="Rv0512"/>
      <fbc:geneProduct fbc:id="G_Rv1391" fbc:label="Rv1391" fbc:name="Rv1391"/>
      <fbc:geneProduct fbc:id="G_Rv0973c" fbc:label="Rv0973c" fbc:name="Rv0973c"/>
      <fbc:geneProduct fbc:id="G_Rv2501c" fbc:label="Rv2501c" fbc:name="Rv2501c"/>
      <fbc:geneProduct fbc:id="G_Rv2502c" fbc:label="Rv2502c" fbc:name="Rv2502c"/>
      <fbc:geneProduct fbc:id="G_Rv0974c" fbc:label="Rv0974c" fbc:name="Rv0974c"/>
      <fbc:geneProduct fbc:id="G_Rv3285" fbc:label="Rv3285" fbc:name="Rv3285"/>
      <fbc:geneProduct fbc:id="G_Rv2247" fbc:label="Rv2247" fbc:name="Rv2247"/>
      <fbc:geneProduct fbc:id="G_Rv1127c" fbc:label="Rv1127c" fbc:name="Rv1127c"/>
      <fbc:geneProduct fbc:id="G_Rv2702" fbc:label="Rv2702" fbc:name="Rv2702"/>
      <fbc:geneProduct fbc:id="G_Rv2984" fbc:label="Rv2984" fbc:name="Rv2984"/>
      <fbc:geneProduct fbc:id="G_Rv3754" fbc:label="Rv3754" fbc:name="Rv3754"/>
      <fbc:geneProduct fbc:id="G_Rv3838c" fbc:label="Rv3838c" fbc:name="Rv3838c"/>
      <fbc:geneProduct fbc:id="G_Rv2677c" fbc:label="Rv2677c" fbc:name="Rv2677c"/>
      <fbc:geneProduct fbc:id="G_Rv2163c" fbc:label="Rv2163c" fbc:name="Rv2163c"/>
      <fbc:geneProduct fbc:id="G_Rv0772" fbc:label="Rv0772" fbc:name="Rv0772"/>
      <fbc:geneProduct fbc:id="G_Rv0809" fbc:label="Rv0809" fbc:name="Rv0809"/>
      <fbc:geneProduct fbc:id="G_Rv1603" fbc:label="Rv1603" fbc:name="Rv1603"/>
      <fbc:geneProduct fbc:id="G_Rv1606" fbc:label="Rv1606" fbc:name="Rv1606"/>
      <fbc:geneProduct fbc:id="G_Rv0780" fbc:label="Rv0780" fbc:name="Rv0780"/>
      <fbc:geneProduct fbc:id="G_Rv2122c" fbc:label="Rv2122c" fbc:name="Rv2122c"/>
      <fbc:geneProduct fbc:id="G_Rv2928" fbc:label="Rv2928" fbc:name="Rv2928"/>
      <fbc:geneProduct fbc:id="G_Rv2935" fbc:label="Rv2935" fbc:name="Rv2935"/>
      <fbc:geneProduct fbc:id="G_Rv2932" fbc:label="Rv2932" fbc:name="Rv2932"/>
      <fbc:geneProduct fbc:id="G_Rv2934" fbc:label="Rv2934" fbc:name="Rv2934"/>
      <fbc:geneProduct fbc:id="G_Rv2933" fbc:label="Rv2933" fbc:name="Rv2933"/>
      <fbc:geneProduct fbc:id="G_Rv2931" fbc:label="Rv2931" fbc:name="Rv2931"/>
      <fbc:geneProduct fbc:id="G_Rv0788" fbc:label="Rv0788" fbc:name="Rv0788"/>
      <fbc:geneProduct fbc:id="G_Rv0803" fbc:label="Rv0803" fbc:name="Rv0803"/>
      <fbc:geneProduct fbc:id="G_Rv1188" fbc:label="Rv1188" fbc:name="Rv1188"/>
      <fbc:geneProduct fbc:id="G_Rv1017c" fbc:label="Rv1017c" fbc:name="Rv1017c"/>
      <fbc:geneProduct fbc:id="G_Rv3227" fbc:label="Rv3227" fbc:name="Rv3227"/>
      <fbc:geneProduct fbc:id="G_Rv0437c" fbc:label="Rv0437c" fbc:name="Rv0437c"/>
      <fbc:geneProduct fbc:id="G_Rv3042c" fbc:label="Rv3042c" fbc:name="Rv3042c"/>
      <fbc:geneProduct fbc:id="G_Rv0505c" fbc:label="Rv0505c" fbc:name="Rv0505c"/>
      <fbc:geneProduct fbc:id="G_Rv0436c" fbc:label="Rv0436c" fbc:name="Rv0436c"/>
      <fbc:geneProduct fbc:id="G_Rv0408" fbc:label="Rv0408" fbc:name="Rv0408"/>
      <fbc:geneProduct fbc:id="G_Rv2965c" fbc:label="Rv2965c" fbc:name="Rv2965c"/>
      <fbc:geneProduct fbc:id="G_Rv3307" fbc:label="Rv3307" fbc:name="Rv3307"/>
      <fbc:geneProduct fbc:id="G_Rv1617" fbc:label="Rv1617" fbc:name="Rv1617"/>
      <fbc:geneProduct fbc:id="G_Rv0162c" fbc:label="Rv0162c" fbc:name="Rv0162c"/>
      <fbc:geneProduct fbc:id="G_Rv3777" fbc:label="Rv3777" fbc:name="Rv3777"/>
      <fbc:geneProduct fbc:id="G_Rv1594" fbc:label="Rv1594" fbc:name="Rv1594"/>
      <fbc:geneProduct fbc:id="G_Rv2064" fbc:label="Rv2064" fbc:name="Rv2064"/>
      <fbc:geneProduct fbc:id="G_Rv1416" fbc:label="Rv1416" fbc:name="Rv1416"/>
      <fbc:geneProduct fbc:id="G_Rv1412" fbc:label="Rv1412" fbc:name="Rv1412"/>
      <fbc:geneProduct fbc:id="G_Rv2436" fbc:label="Rv2436" fbc:name="Rv2436"/>
      <fbc:geneProduct fbc:id="G_Rv1981c" fbc:label="Rv1981c" fbc:name="Rv1981c"/>
      <fbc:geneProduct fbc:id="G_Rv0570" fbc:label="Rv0570" fbc:name="Rv0570"/>
      <fbc:geneProduct fbc:id="G_Rv3051c" fbc:label="Rv3051c" fbc:name="Rv3051c"/>
      <fbc:geneProduct fbc:id="G_Rv3048c" fbc:label="Rv3048c" fbc:name="Rv3048c"/>
      <fbc:geneProduct fbc:id="G_Rv1408" fbc:label="Rv1408" fbc:name="Rv1408"/>
      <fbc:geneProduct fbc:id="G_Rv2465c" fbc:label="Rv2465c" fbc:name="Rv2465c"/>
      <fbc:geneProduct fbc:id="G_Rv2962c" fbc:label="Rv2962c" fbc:name="Rv2962c"/>
      <fbc:geneProduct fbc:id="G_Rv2958c" fbc:label="Rv2958c" fbc:name="Rv2958c"/>
      <fbc:geneProduct fbc:id="G_Rv3113" fbc:label="Rv3113" fbc:name="Rv3113"/>
      <fbc:geneProduct fbc:id="G_Rv2386c" fbc:label="Rv2386c" fbc:name="Rv2386c"/>
      <fbc:geneProduct fbc:id="G_Rv1202" fbc:label="Rv1202" fbc:name="Rv1202"/>
      <fbc:geneProduct fbc:id="G_Rv0858c" fbc:label="Rv0858c" fbc:name="Rv0858c"/>
      <fbc:geneProduct fbc:id="G_Rv1464" fbc:label="Rv1464" fbc:name="Rv1464"/>
      <fbc:geneProduct fbc:id="G_Rv2335" fbc:label="Rv2335" fbc:name="Rv2335"/>
      <fbc:geneProduct fbc:id="G_Rv0069c" fbc:label="Rv0069c" fbc:name="Rv0069c"/>
      <fbc:geneProduct fbc:id="G_Rv2847c" fbc:label="Rv2847c" fbc:name="Rv2847c"/>
      <fbc:geneProduct fbc:id="G_Rv2552c" fbc:label="Rv2552c" fbc:name="Rv2552c"/>
      <fbc:geneProduct fbc:id="G_Rv2539c" fbc:label="Rv2539c" fbc:name="Rv2539c"/>
      <fbc:geneProduct fbc:id="G_Rv1079" fbc:label="Rv1079" fbc:name="Rv1079"/>
      <fbc:geneProduct fbc:id="G_Rv0391" fbc:label="Rv0391" fbc:name="Rv0391"/>
      <fbc:geneProduct fbc:id="G_Rv1200" fbc:label="Rv1200" fbc:name="Rv1200"/>
      <fbc:geneProduct fbc:id="G_Rv2601" fbc:label="Rv2601" fbc:name="Rv2601"/>
      <fbc:geneProduct fbc:id="G_Rv0432" fbc:label="Rv0432" fbc:name="Rv0432"/>
      <fbc:geneProduct fbc:id="G_Rv3846" fbc:label="Rv3846" fbc:name="Rv3846"/>
      <fbc:geneProduct fbc:id="G_Rv0234c" fbc:label="Rv0234c" fbc:name="Rv0234c"/>
      <fbc:geneProduct fbc:id="G_Rv1731" fbc:label="Rv1731" fbc:name="Rv1731"/>
      <fbc:geneProduct fbc:id="G_Rv0542c" fbc:label="Rv0542c" fbc:name="Rv0542c"/>
      <fbc:geneProduct fbc:id="G_Rv0553" fbc:label="Rv0553" fbc:name="Rv0553"/>
      <fbc:geneProduct fbc:id="G_Rv0951" fbc:label="Rv0951" fbc:name="Rv0951"/>
      <fbc:geneProduct fbc:id="G_Rv0952" fbc:label="Rv0952" fbc:name="Rv0952"/>
      <fbc:geneProduct fbc:id="G_Rv2399c" fbc:label="Rv2399c" fbc:name="Rv2399c"/>
      <fbc:geneProduct fbc:id="G_Rv1739c" fbc:label="Rv1739c" fbc:name="Rv1739c"/>
      <fbc:geneProduct fbc:id="G_Rv2398c" fbc:label="Rv2398c" fbc:name="Rv2398c"/>
      <fbc:geneProduct fbc:id="G_Rv2400c" fbc:label="Rv2400c" fbc:name="Rv2400c"/>
      <fbc:geneProduct fbc:id="G_Rv2397c" fbc:label="Rv2397c" fbc:name="Rv2397c"/>
      <fbc:geneProduct fbc:id="G_Rv1448c" fbc:label="Rv1448c" fbc:name="Rv1448c"/>
      <fbc:geneProduct fbc:id="G_Rv1672c" fbc:label="Rv1672c" fbc:name="Rv1672c"/>
      <fbc:geneProduct fbc:id="G_Rv3465" fbc:label="Rv3465" fbc:name="Rv3465"/>
      <fbc:geneProduct fbc:id="G_Rv3266c" fbc:label="Rv3266c" fbc:name="Rv3266c"/>
      <fbc:geneProduct fbc:id="G_Rv3784" fbc:label="Rv3784" fbc:name="Rv3784"/>
      <fbc:geneProduct fbc:id="G_Rv3464" fbc:label="Rv3464" fbc:name="Rv3464"/>
      <fbc:geneProduct fbc:id="G_Rv3468c" fbc:label="Rv3468c" fbc:name="Rv3468c"/>
      <fbc:geneProduct fbc:id="G_Rv2713" fbc:label="Rv2713" fbc:name="Rv2713"/>
      <fbc:geneProduct fbc:id="G_Rv1201c" fbc:label="Rv1201c" fbc:name="Rv1201c"/>
      <fbc:geneProduct fbc:id="G_Rv1559" fbc:label="Rv1559" fbc:name="Rv1559"/>
      <fbc:geneProduct fbc:id="G_Rv3737" fbc:label="Rv3737" fbc:name="Rv3737"/>
      <fbc:geneProduct fbc:id="G_Rv2291" fbc:label="Rv2291" fbc:name="Rv2291"/>
      <fbc:geneProduct fbc:id="G_Rv0417" fbc:label="Rv0417" fbc:name="Rv0417"/>
      <fbc:geneProduct fbc:id="G_Rv1449c" fbc:label="Rv1449c" fbc:name="Rv1449c"/>
      <fbc:geneProduct fbc:id="G_Rv3314c" fbc:label="Rv3314c" fbc:name="Rv3314c"/>
      <fbc:geneProduct fbc:id="G_Rv2754c" fbc:label="Rv2754c" fbc:name="Rv2754c"/>
      <fbc:geneProduct fbc:id="G_Rv2764c" fbc:label="Rv2764c" fbc:name="Rv2764c"/>
      <fbc:geneProduct fbc:id="G_Rv2977c" fbc:label="Rv2977c" fbc:name="Rv2977c"/>
      <fbc:geneProduct fbc:id="G_Rv0414c" fbc:label="Rv0414c" fbc:name="Rv0414c"/>
      <fbc:geneProduct fbc:id="G_Rv1438" fbc:label="Rv1438" fbc:name="Rv1438"/>
      <fbc:geneProduct fbc:id="G_Rv3913" fbc:label="Rv3913" fbc:name="Rv3913"/>
      <fbc:geneProduct fbc:id="G_Rv2006" fbc:label="Rv2006" fbc:name="Rv2006"/>
      <fbc:geneProduct fbc:id="G_Rv3372" fbc:label="Rv3372" fbc:name="Rv3372"/>
      <fbc:geneProduct fbc:id="G_Rv3490" fbc:label="Rv3490" fbc:name="Rv3490"/>
      <fbc:geneProduct fbc:id="G_Rv0295c" fbc:label="Rv0295c" fbc:name="Rv0295c"/>
      <fbc:geneProduct fbc:id="G_Rv1373" fbc:label="Rv1373" fbc:name="Rv1373"/>
      <fbc:geneProduct fbc:id="G_Rv1613" fbc:label="Rv1613" fbc:name="Rv1613"/>
      <fbc:geneProduct fbc:id="G_Rv1612" fbc:label="Rv1612" fbc:name="Rv1612"/>
      <fbc:geneProduct fbc:id="G_Rv2158c" fbc:label="Rv2158c" fbc:name="Rv2158c"/>
      <fbc:geneProduct fbc:id="G_Rv1315" fbc:label="Rv1315" fbc:name="Rv1315"/>
      <fbc:geneProduct fbc:id="G_Rv2153c" fbc:label="Rv2153c" fbc:name="Rv2153c"/>
      <fbc:geneProduct fbc:id="G_Rv2155c" fbc:label="Rv2155c" fbc:name="Rv2155c"/>
      <fbc:geneProduct fbc:id="G_Rv2152c" fbc:label="Rv2152c" fbc:name="Rv2152c"/>
      <fbc:geneProduct fbc:id="G_Rv3818" fbc:label="Rv3818" fbc:name="Rv3818"/>
      <fbc:geneProduct fbc:id="G_Rv0482" fbc:label="Rv0482" fbc:name="Rv0482"/>
      <fbc:geneProduct fbc:id="G_Rv2361c" fbc:label="Rv2361c" fbc:name="Rv2361c"/>
      <fbc:geneProduct fbc:id="G_Rv0501" fbc:label="Rv0501" fbc:name="Rv0501"/>
      <fbc:geneProduct fbc:id="G_Rv0536" fbc:label="Rv0536" fbc:name="Rv0536"/>
      <fbc:geneProduct fbc:id="G_Rv3634c" fbc:label="Rv3634c" fbc:name="Rv3634c"/>
      <fbc:geneProduct fbc:id="G_Rv3809c" fbc:label="Rv3809c" fbc:name="Rv3809c"/>
      <fbc:geneProduct fbc:id="G_Rv0322" fbc:label="Rv0322" fbc:name="Rv0322"/>
      <fbc:geneProduct fbc:id="G_Rv2157c" fbc:label="Rv2157c" fbc:name="Rv2157c"/>
      <fbc:geneProduct fbc:id="G_Rv2678c" fbc:label="Rv2678c" fbc:name="Rv2678c"/>
      <fbc:geneProduct fbc:id="G_Rv3309c" fbc:label="Rv3309c" fbc:name="Rv3309c"/>
      <fbc:geneProduct fbc:id="G_Rv1848" fbc:label="Rv1848" fbc:name="Rv1848"/>
      <fbc:geneProduct fbc:id="G_Rv1849" fbc:label="Rv1849" fbc:name="Rv1849"/>
      <fbc:geneProduct fbc:id="G_Rv1850" fbc:label="Rv1850" fbc:name="Rv1850"/>
      <fbc:geneProduct fbc:id="G_Rv2883c" fbc:label="Rv2883c" fbc:name="Rv2883c"/>
      <fbc:geneProduct fbc:id="G_Rv0729" fbc:label="Rv0729" fbc:name="Rv0729"/>
      <fbc:geneProduct fbc:id="G_Rv3455c" fbc:label="Rv3455c" fbc:name="Rv3455c"/>
      <fbc:geneProduct fbc:id="G_Rv2793c" fbc:label="Rv2793c" fbc:name="Rv2793c"/>
      <fbc:geneProduct fbc:id="G_Rv3409c" fbc:label="Rv3409c" fbc:name="Rv3409c"/>
      <fbc:geneProduct fbc:id="G_Rv3518c" fbc:label="Rv3518c" fbc:name="Rv3518c"/>
      <fbc:geneProduct fbc:id="G_Rv3545" fbc:label="Rv3545" fbc:name="Rv3545"/>
      <fbc:geneProduct fbc:id="G_Rv1153" fbc:label="Rv1153" fbc:name="Rv1153"/>
      <fbc:geneProduct fbc:id="G_Rv3561" fbc:label="Rv3561" fbc:name="Rv3561"/>
      <fbc:geneProduct fbc:id="G_Rv3140" fbc:label="Rv3140" fbc:name="Rv3140"/>
      <fbc:geneProduct fbc:id="G_Rv1472" fbc:label="Rv1472" fbc:name="Rv1472"/>
      <fbc:geneProduct fbc:id="G_Rv3571" fbc:label="Rv3571" fbc:name="Rv3571"/>
      <fbc:geneProduct fbc:id="G_Rv3526" fbc:label="Rv3526" fbc:name="Rv3526"/>
      <fbc:geneProduct fbc:id="G_Rv3568" fbc:label="Rv3568" fbc:name="Rv3568"/>
      <fbc:geneProduct fbc:id="G_Rv3569c" fbc:label="Rv3569c" fbc:name="Rv3569c"/>
      <fbc:geneProduct fbc:id="G_Rv3536c" fbc:label="Rv3536c" fbc:name="Rv3536c"/>
    </fbc:listOfGeneProducts>
    <listOfReactions>
      <reaction fast="false" id="R_2AGPEAT160" reversible="false" name=" 2-acyl-glycerophospho-ethanolamine acyltransferase (n-C16:0)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_2agpe160[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_hdca[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_amp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pe160[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_2AGPEAT180" reversible="false" name=" 2-acyl-glycerophospho-ethanolamine acyltransferase (n-C18:0)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_2agpe180[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ocdca[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_amp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pe180[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_4HTHRS" reversible="false" name=" 4-Hydroxy-L-threonine synthase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_phthr[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_4hthr[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv1295"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_5DGLCNR" reversible="true" name=" 5-dehydro-D-gluconate reductase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_5dglcn[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadph[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_glcn[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadp[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2573"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_AACPS10" reversible="false" name="acyl-[acyl-carrier-protein] synthetase  (tuberculostearic acid)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_ACP[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_mocdca[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_amp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_mstrACP[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv3815c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_AACPS11" reversible="false" name="acyl-[acyl-carrier-protein] synthetase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_4hbz[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ACP[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_4hbzACP[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_amp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_AACPS3" reversible="false" name="acyl-[acyl-carrier-protein] synthetase  (n-C16:0)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_ACP[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_hdca[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_amp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_palmACP[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_ABTA" reversible="false" name=" 4-aminobutyrate transaminase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_4abut[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_akg[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_glu-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_sucsal[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:or>
            <fbc:geneProductRef fbc:geneProduct="G_Rv3290c"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv2589"/>
          </fbc:or>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_ACACCT" reversible="false" name="acetyl-CoA:acetoacetyl-CoA transferase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_acac[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_accoa[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_aacoa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ac[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_ACACT1r" reversible="true" name="acetyl-CoA C-acetyltransferase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_accoa[c]" stoichiometry="2"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_aacoa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_coa[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv1323"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_ACALDi" reversible="false" name="acetaldehyde dehydrogenase (acetylating)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_acald[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_coa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nad[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_accoa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadh[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv3535c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_ACBIPGT" reversible="false" name="Adenosyl cobinamide phosphate guanyltransferase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_adocbip[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_gtp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_agdpcbi[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv0254c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_ACCC" reversible="false" name="Acyl-CoA Carboxylase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_hexccoa[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_chexccoa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv3280"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_ACCOACr" reversible="true" name="acetyl-CoA carboxylase, reversible reaction" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_accoa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_hco3[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_malcoa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:or>
            <fbc:and>
              <fbc:geneProductRef fbc:geneProduct="G_Rv3280"/>
              <fbc:geneProductRef fbc:geneProduct="G_Rv0904c"/>
            </fbc:and>
            <fbc:and>
              <fbc:geneProductRef fbc:geneProduct="G_Rv3280"/>
              <fbc:geneProductRef fbc:geneProduct="G_Rv3281"/>
            </fbc:and>
          </fbc:or>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_ACChex" reversible="false" name="Hexanoic Acid CoA Ligase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_coa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_hexc[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_hexccoa[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv3280"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_ACGAMPM" reversible="true" name="phosphoacetylglucosamine mutase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_acgam6p[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_acgam1p[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv3441c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_ACGAMT" reversible="false" name="UDP-N-acetylglucosamine:undecaprenylphosphate N-acetylglucosamine -1-phosphate transferase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_uacgam[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_udcpp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ump[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_unaga[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv1302"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_ACGK" reversible="false" name="acetylglutamate kinase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_acglu[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_acg5p[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv1654"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_ACGS" reversible="false" name="N-acetylglutamate synthase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_accoa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_glu-L[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_acglu[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_coa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv1653"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_ACHBS" reversible="false" name=" 2-aceto-2-hydroxybutanoate synthase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_2obut[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pyr[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_2ahbut[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_ACKr" reversible="true" name="acetate kinase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_ac[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_actp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv0409"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_ACLS" reversible="false" name="acetolactate synthase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pyr[c]" stoichiometry="2"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_alac-S[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:or>
            <fbc:and>
              <fbc:geneProductRef fbc:geneProduct="G_Rv3002c"/>
              <fbc:geneProductRef fbc:geneProduct="G_Rv3509c"/>
            </fbc:and>
            <fbc:and>
              <fbc:geneProductRef fbc:geneProduct="G_Rv3002c"/>
              <fbc:geneProductRef fbc:geneProduct="G_Rv3509c"/>
            </fbc:and>
            <fbc:and>
              <fbc:geneProductRef fbc:geneProduct="G_Rv3470c"/>
              <fbc:geneProductRef fbc:geneProduct="G_Rv3002c"/>
            </fbc:and>
            <fbc:and>
              <fbc:geneProductRef fbc:geneProduct="G_Rv3002c"/>
              <fbc:geneProductRef fbc:geneProduct="G_Rv3003c"/>
            </fbc:and>
            <fbc:and>
              <fbc:geneProductRef fbc:geneProduct="G_Rv1820"/>
              <fbc:geneProductRef fbc:geneProduct="G_Rv3002c"/>
            </fbc:and>
          </fbc:or>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_ACODA" reversible="false" name="acetylornithine deacetylase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_acorn[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ac[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_orn[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_ACONT" reversible="true" name="aconitase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_cit[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_icit[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv1475c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_ACOTA" reversible="true" name="acetylornithine transaminase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_acorn[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_akg[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_acg5sa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_glu-L[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv1655"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_ACP1_FMN" reversible="false" name="acid phosphatase (FMN)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_fmn[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ribflv[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv3310"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_ACPS1" reversible="false" name="acyl-carrier protein synthase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_apoACP[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_coa[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ACP[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pap[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2523c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_ACS" reversible="false" name="acetyl-CoA synthetase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_ac[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_coa[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_accoa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_amp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv3667"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_ACS2" reversible="false" name="acetyl-CoA synthase (propionate)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_coa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ppa[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_amp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ppcoa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv3667"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_ACYSBMNt" reversible="true" name="acysbmn transport (mtb)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_acysbmn[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_acysbmn[e]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_ADA" reversible="false" name="Adenosine deaminase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_adn[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ins[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nh4[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv3313c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_ADCL" reversible="false" name=" 4-aminobenzoate synthase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_4adcho[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_4abz[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pyr[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv0812"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_ADCPS1" reversible="false" name="adenosylcobinamide-phosphate synthase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_adcobhex[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_appl[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adocbi[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2236c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_ADCPS2" reversible="false" name="adenosylcobinamide-phosphate synthase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_adcobhex[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_applp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adocbip[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:or>
            <fbc:geneProductRef fbc:geneProduct="G_Rv0254c"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv2236c"/>
          </fbc:or>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_ADCS" reversible="false" name=" 4-amino-4-deoxychorismate synthase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_chor[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_gln-L[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_4adcho[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_glu-L[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_Rv0013"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1005c"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_ADCYRS" reversible="false" name="adenosylcobyric acid synthase (glutamine-hydrolysing)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_adcobdam[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="4"/>
          <speciesReference constant="true" species="M_gln-L[c]" stoichiometry="4"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="4"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adcobhex[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="4"/>
          <speciesReference constant="true" species="M_glu-L[c]" stoichiometry="4"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="4"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="4"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:or>
            <fbc:geneProductRef fbc:geneProduct="G_Rv2848c"/>
            <fbc:and>
              <fbc:geneProductRef fbc:geneProduct="G_Rv0255c"/>
              <fbc:geneProductRef fbc:geneProduct="G_Rv3713"/>
            </fbc:and>
          </fbc:or>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_ADK1" reversible="true" name="adenylate kinase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_amp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="2"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv0733"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_ADK2" reversible="true" name="adenylate kinase (Inorganic triphosphate)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_amp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pppi[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv0733"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_ADK3" reversible="true" name="adentylate kinase (GTP)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_amp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_gtp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_gdp[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv0733"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_ADK4" reversible="true" name="adentylate kinase (ITP)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_amp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_itp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_idp[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv0733"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_ADMDCr" reversible="true" name="Adenosylmethionine decarboxylase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_amet[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ametam[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_ADNCYC" reversible="false" name="adenylate cyclase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_camp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:or>
            <fbc:or>
              <fbc:geneProductRef fbc:geneProduct="G_Rv1264"/>
              <fbc:and>
                <fbc:geneProductRef fbc:geneProduct="G_Rv1320c"/>
                <fbc:geneProductRef fbc:geneProduct="G_Rv1319c"/>
                <fbc:geneProductRef fbc:geneProduct="G_Rv1318c"/>
              </fbc:and>
              <fbc:geneProductRef fbc:geneProduct="G_Rv1647"/>
              <fbc:geneProductRef fbc:geneProduct="G_Rv1625c"/>
            </fbc:or>
            <fbc:geneProductRef fbc:geneProduct="G_Rv2435c"/>
          </fbc:or>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_ADNK1" reversible="false" name="adenosine kinase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_adn[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_amp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2202c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_ADNK3" reversible="false" name="adenosine kinase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_adn[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_gtp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_amp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_gdp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2202c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_ADNK4" reversible="false" name="adenosine kinase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_adn[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_dgtp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_amp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_dgdp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2202c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_ADOCBIK" reversible="false" name="Adenosyl cobinamide kinase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_adocbi[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adocbip[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv0254c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_ADOCBLS" reversible="false" name="Adenosylcobalamin 5&apos;-phosphate synthase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_agdpcbi[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_rdmbzi[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adocbl[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_gmp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2208"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_ADPT" reversible="false" name="adenine phosphoribosyltransferase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_ade[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_prpp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_amp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2584c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_ADSK" reversible="false" name="adenylyl-sulfate kinase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_aps[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_paps[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1286"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1285"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_ADSL1r" reversible="true" name="adenylsuccinate lyase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_dcamp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_amp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_fum[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:or>
            <fbc:or>
              <fbc:geneProductRef fbc:geneProduct="G_Rv0777"/>
              <fbc:geneProductRef fbc:geneProduct="G_Rv0777"/>
            </fbc:or>
            <fbc:or>
              <fbc:geneProductRef fbc:geneProduct="G_Rv0777"/>
              <fbc:geneProductRef fbc:geneProduct="G_Rv0777"/>
            </fbc:or>
          </fbc:or>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_ADSL2r" reversible="true" name="adenylosuccinate lyase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_25aics[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_aicar[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_fum[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:or>
            <fbc:or>
              <fbc:geneProductRef fbc:geneProduct="G_Rv0777"/>
              <fbc:geneProductRef fbc:geneProduct="G_Rv0777"/>
            </fbc:or>
            <fbc:or>
              <fbc:geneProductRef fbc:geneProduct="G_Rv0777"/>
              <fbc:geneProductRef fbc:geneProduct="G_Rv0777"/>
            </fbc:or>
          </fbc:or>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_ADSS" reversible="false" name="adenylosuccinate synthase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_asp-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_gtp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_imp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_dcamp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_gdp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv0357c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_AFE" reversible="false" name="arabinofuranosyl extension (M tb)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_agalfragund[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_arabinan[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_arabinanagalfragund[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_Rv3794"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv3795"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv3793"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_AFTA" reversible="false" name="arabinofuranosyl transferase (M tb)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_decda_tb[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_galfragund[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_agalfragund[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_decd_tb[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv3792"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_AGDC" reversible="false" name="N-acetylglucosamine-6-phosphate deacetylase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_acgam6p[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ac[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_gam6p[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv3332"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_AGMT" reversible="false" name="agmatinase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_agm[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ptrc[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_urea[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_AGPAT160" reversible="false" name=" 1-hexadecanoyl-sn-glycerol 3-phosphate O-acyltransferase (n-C16:0)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_1hdecg3p[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_palmACP[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ACP[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pa160[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:or>
            <fbc:geneProductRef fbc:geneProduct="G_Rv2182c"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv2483c"/>
          </fbc:or>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_AGPAT160190" reversible="false" name=" 1-hexadecanoyl-sn-glycerol 3-phosphate O-acyltransferase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_1hdecg3p[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_mstrACP[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ACP[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pa160190[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:or>
            <fbc:geneProductRef fbc:geneProduct="G_Rv2182c"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv2483c"/>
          </fbc:or>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_AGPAT190" reversible="false" name=" 1-hexadecanoyl-sn-glycerol 3-phosphate O-acyltransferase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_1msg3p[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_mstrACP[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ACP[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pa190190[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:or>
            <fbc:geneProductRef fbc:geneProduct="G_Rv2483c"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv2182c"/>
          </fbc:or>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_AGPR" reversible="true" name="N-acetyl-g-glutamyl-phosphate reductase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_acg5sa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_acg5p[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadph[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv1652"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_AHC" reversible="true" name="adenosylhomocysteinase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_ahcys[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adn[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_hcys-L[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv3248c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_AHCYSNS" reversible="false" name="S-adenosylhomocysteine nucleosidase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_ahcys[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ade[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_rhcys[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv0091"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_AHMMPS" reversible="false" name=" 4-amino-5-hydroxymethyl-2-methylpyrimidine synthetase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_air[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="2"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_4ahmmp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_gcald[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv0423c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_AICART" reversible="true" name="phosphoribosylaminoimidazolecarboxamide formyltransferase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_10fthf[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_aicar[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_fprica[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_thf[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv0957"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_AICART2" reversible="true" name="phosphoribosylaminoimidazolecarboxamide formyltransferase 2" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_aicar[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_for[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_fprica[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_AIRC2" reversible="false" name="phosphoribosylaminoimidazole carboxylase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_air[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_hco3[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_5caiz[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_AIRC3" reversible="true" name="phosphoribosylaminoimidazole carboxylase (mutase rxn)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_5aizc[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_5caiz[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_AIRCr" reversible="true" name="phosphoribosylaminoimidazole carboxylase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_air[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_5aizc[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:or>
            <fbc:and>
              <fbc:geneProductRef fbc:geneProduct="G_Rv3276c"/>
              <fbc:geneProductRef fbc:geneProduct="G_Rv3257c"/>
            </fbc:and>
            <fbc:and>
              <fbc:geneProductRef fbc:geneProduct="G_Rv3276c"/>
              <fbc:geneProductRef fbc:geneProduct="G_Rv3275c"/>
            </fbc:and>
          </fbc:or>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_AKGDb" reversible="false" name="oxoglutarate dehydrogenase (dihydrolipoamide S-succinyltransferase)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_coa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_sdhlam[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_dhlam[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_succoa[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2215"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_ALAALAD" reversible="false" name="D-alanine-D-alanine dipeptidase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_alaala[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ala-D[c]" stoichiometry="2"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv3330"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_ALAALAr" reversible="true" name="D-alanine-D-alanine ligase (reversible)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_ala-D[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_alaala[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2981c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_ALAD_L" reversible="false" name="L-alanine dehydrogenase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_ala-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nad[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadh[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nh4[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pyr[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2780"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_ALAR" reversible="true" name="alanine racemase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_ala-L[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ala-D[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv3423c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_ALATA_L" reversible="true" name="L-alanine transaminase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_akg[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ala-L[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_glu-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pyr[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_ALATRS" reversible="false" name="Alanyl-tRNA synthetase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_ala-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_trnaala[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_alatrna[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_amp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2992c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_ALAt2r" reversible="true" name="L-alanine reversible transport via proton symport" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_ala-L[e]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ala-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_ALDD1" reversible="false" name="aldehyde dehydrogenase (formaldehyde, NAD)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_fald[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nad[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_for[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_nadh[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:or>
            <fbc:geneProductRef fbc:geneProduct="G_Rv3045"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1895"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv2259"/>
          </fbc:or>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_ALDD19x" reversible="false" name="aldehyde dehydrogenase (phenylacetaldehyde, NAD)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nad[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pacald[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_nadh[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pac[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2858c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_ALDD2x" reversible="false" name="aldehyde dehydrogenase (acetaldehyde, NAD)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_acald[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nad[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ac[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_nadh[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:or>
            <fbc:and>
              <fbc:geneProductRef fbc:geneProduct="G_Rv3293"/>
              <fbc:geneProductRef fbc:geneProduct="G_Rv0768"/>
            </fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_Rv0147"/>
          </fbc:or>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_AMAOTr" reversible="true" name="adenosylmethionine-8-amino-7-oxononanoate transaminase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_8aonn[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_amet[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_amob[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_dann[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv1568"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_AMID4" reversible="false" name="amidase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_ad[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ac[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nh4[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2363"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_AMMQT6" reversible="false" name="S-adenosylmethione" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_2dmmq6[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_amet[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ahcys[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_mqn6[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_AMMQT8" reversible="false" name="S-adenosylmethione:2-demthylmenaquinone methyltransferase (menaquinone 8)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_2dmmq8[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_amet[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ahcys[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_mql8[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv0558"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_AMMQT8_2" reversible="false" name="S-adenosylmethione:2-demethylmenaquinone methyltransferase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_2dmmq8[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_amet[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ahcys[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_mqn8[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_AMPTASECG" reversible="false" name="alanyl aminopeptidase (cys-gly)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_cgly[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_cys-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_gly[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2467"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_ANPRT" reversible="false" name="anthranilate phosphoribosyltransferase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_anth[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_prpp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pran[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2192c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_ANS" reversible="false" name="anthranilate synthase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_chor[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_gln-L[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_anth[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_glu-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pyr[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:or>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1609"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv2859c"/>
          </fbc:or>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_AOXSr" reversible="true" name=" 8-amino-7-oxononanoate synthase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_ala-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pmcoa[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_8aonn[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_coa[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:or>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1569"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv0032"/>
          </fbc:or>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_APATr" reversible="true" name="B-alanine-pyruvate aminotransferase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_ala-B[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pyr[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ala-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_msa[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_APRAUR" reversible="false" name=" 5-amino-6-(5-phosphoribosylamino)uracil reductase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_5apru[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadph[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_5aprbu[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadp[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2671"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_ARABF" reversible="false" name="arabinan complex formation (M tb)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_arab-D[c]" stoichiometry="12"/>
          <speciesReference constant="true" species="M_mharab-D[c]" stoichiometry="8"/>
          <speciesReference constant="true" species="M_tarab-D[c]" stoichiometry="12"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_arabinan[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="32"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_ARABI" reversible="true" name="arabinose isomerase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_arab-D[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_rbl-D[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_ARACHTA" reversible="true" name="transacylase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_ACP[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_arachcoa[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_arachACP[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_coa[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_ARAI" reversible="true" name="L-arabinose isomerase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_arab-L[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_rbl-L[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_ARB_Dabc" reversible="false" name="L-arabinose transport via ABC system" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_arab-D[e]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_arab-D[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_ARBabc" reversible="false" name="L-arabinose transport via ABC system" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_arab-L[e]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_arab-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_ARBt2r" reversible="true" name="L-arabinose transport via proton symport" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_arab-L[e]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_arab-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_ARGDC" reversible="false" name="arginine decarboxylase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_arg-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_agm[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2531c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_ARGDr" reversible="true" name="arginine deiminase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_arg-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_citr-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nh4[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv1001"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_ARGSL" reversible="true" name="argininosuccinate lyase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_argsuc[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_arg-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_fum[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv1659"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_ARGSS" reversible="false" name="argininosuccinate synthase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_asp-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_citr-L[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_amp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_argsuc[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv1658"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_ARGt5r" reversible="true" name="L-arginine transport via diffusion" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_arg-L[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_arg-L[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2320c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_ARI" reversible="true" name="arabinose ribose isomerase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_arpp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_prpp[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_ASAD" reversible="true" name="aspartate-semialdehyde dehydrogenase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_aspsa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_4pasp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadph[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv3708c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_ASNN" reversible="false" name="L-asparaginase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_asn-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_asp-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nh4[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv1538c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_ASNS1" reversible="false" name="asparagine synthase (glutamine-hydrolysing)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_asp-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_gln-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_amp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_asn-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_glu-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2201"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_ASNt2r" reversible="true" name="L-asparagine reversible transport via proton symport" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_asn-L[e]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_asn-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:or>
            <fbc:geneProductRef fbc:geneProduct="G_Rv2127"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv0346c"/>
          </fbc:or>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_ASP1DC" reversible="false" name="aspartate 1-decarboxylase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_asp-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ala-B[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv3601c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_ASPCT" reversible="false" name="aspartate carbamoyltransferase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_asp-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_cbp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_cbasp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv1380"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_ASPK" reversible="true" name="aspartate kinase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_asp-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_4pasp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv3709c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_ASPO1" reversible="false" name="L-aspartate oxidase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_asp-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_o2[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h2o2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nh4[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_oaa[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv1595"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_ASPO5" reversible="false" name="L-aspartate oxidase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_asp-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_fum[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_iasp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_succ[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv1595"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_ASPTA" reversible="true" name="aspartate transaminase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_akg[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_asp-L[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_glu-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_oaa[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:or>
            <fbc:geneProductRef fbc:geneProduct="G_Rv3565"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv0337c"/>
          </fbc:or>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_ASPt2r" reversible="true" name="L-aspartate reversible transport via proton symport" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_asp-L[e]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_asp-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_AST" reversible="false" name="Arginine succinyltransferase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_arg-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_succoa[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_coa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_sucarg[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_ATPPRT" reversible="false" name="ATP phosphoribosyltransferase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_prpp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_prbatp[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2121c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_ATPS1" reversible="false" name="H+-exporting ATPase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[e]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1306"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1309"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1304"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1307"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1305"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1310"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1311"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1308"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_ATPS4r" reversible="true" name="ATP synthase (four protons for one ATP)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[e]" stoichiometry="4"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="3"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1306"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1309"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1304"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1307"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1305"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1310"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1311"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1308"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_BACCL" reversible="false" name="biotin-[acetyl-CoA-carboxylase] ligase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_btn[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_btamp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv3279c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_BALAt2r" reversible="true" name="beta-alanine reversible transport via proton symport" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_ala-B[e]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ala-B[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv0522"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_BDH" reversible="true" name="(R)-3-Hydroxybutanoate:NAD+ oxidoreductase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_bhb[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nad[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_acac[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadh[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_BETALDHx" reversible="false" name="betaine-aldehyde dehydrogenase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_betald[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nad[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_glyb[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_nadh[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_BMNMSHS" reversible="false" name="conjugated mycothiol synthesis" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_bmn[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_msh[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_bmnmsh[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="2"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_BMNt" reversible="true" name="bimane transport (diffusion)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_bmn[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_bmn[e]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_BPNT" reversible="false" name=" 3&apos;,5&apos;-bisphosphate nucleotidase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pap[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_amp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_BTS2" reversible="true" name="biotin synthase (ala-L producing)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_cys-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_dtbt[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ala-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_btn[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="2"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv1589"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_BTS3r" reversible="true" name="biotin synthase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_dtbt[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_s[c]" stoichiometry="2"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_btn[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2s[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv1589"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_CAATPS" reversible="false" name="Ca ATPase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ca2[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ca2[e]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_h[e]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv0107c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_CAT" reversible="false" name="catalase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h2o2[c]" stoichiometry="2"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_o2[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv1908c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_CAt4" reversible="true" name="calcium transport in/out via proton antiporter" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_ca2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ca2[e]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv1607"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_CBIAT" reversible="true" name="Cobinamide adenyltransferase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_cbi[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adocbi[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pppi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2849c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_CBLAT" reversible="true" name="cob(I)alamin adenosyltransferase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_cbl1[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adocbl[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pppi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2849c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_CBPS" reversible="false" name="carbamoyl-phosphate synthase (glutamine-hydrolysing)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_gln-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_hco3[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_cbp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_glu-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv1383"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_CDAPPA160" reversible="false" name="CDP-Diacylglycerol pyrophostatase (n-C16:0)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_cdpdhdecg[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_cmp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_pa160[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2289"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_CDAPPA160190" reversible="false" name="CDP-Diacylglycerol pyrophostatase (C16:0, C19:0)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_cdpc16c19g[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_cmp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_pa160190[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2289"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_CDAPPA190" reversible="false" name="CDP-Diacylglycerol pyrophostatase (C19:0)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_cdpc19c19g[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_cmp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_pa190190[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2289"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_CDPMEK" reversible="false" name=" 4-(cytidine 5&apos;-diphospho)-2-C-methyl-D-erythritol kinase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_4c2me[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_2p4c2me[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv1011"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_CDPPT160" reversible="false" name="CDP diacylglycerol inositon 3-phosphatidyltransferase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_cdpdhdecg[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_inost[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_cmp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ptd1ino160[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2612c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_CDPPT160190" reversible="false" name="CDP diacylglycerol inositon 3-phosphatidyltransferase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_cdpc16c19g[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_inost[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_cmp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ptd1ino160190[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2612c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_CHLabc" reversible="false" name="choline transport via ABC system" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_chol[e]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_chol[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_Rv3757c"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv3759c"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv3756c"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv3758c"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_CHOLD" reversible="false" name="choline dehydrogenase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_chol[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nad[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_betald[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadh[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_CHORM" reversible="false" name="chorismate mutase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_chor[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_pphn[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv1885c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_CHORS" reversible="false" name="chorismate synthase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_3psme[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_chor[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2540c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_CHRPL" reversible="false" name="Chorismate pyruvate lyase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_chor[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_4hbz[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pyr[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2949c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_CIGAMS" reversible="false" name="cys-1D-myo-inositol 2-deoxy-D-glucopyranoside synthase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_cys-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_igam[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_amp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_cigam[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2130c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_CITL" reversible="false" name="Citrate lyase" fbc:upperFluxBound="cobra_0_bound" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_cit[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ac[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_oaa[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_CITLr" reversible="true" name="Citrate lyase (reversible)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_cit[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ac[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_oaa[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:or>
            <fbc:geneProductRef fbc:geneProduct="G_Rv2498c"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv2075c"/>
          </fbc:or>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_CITabc" reversible="false" name="citrate transport via ABC system" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_cit[e]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_cit[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_CLPNS160190" reversible="true" name="cardiolipin synthase (C16:0, C19:0) tuberculosis" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_pg160190[c]" stoichiometry="2"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_clpn160190[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_glyc[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_CMCBTFL" reversible="false" name="carboxymycobactin Fe3 loading" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_cmcbtt[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_fe3[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_fcmcbtt[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_CMCBTFU" reversible="false" name="carboxymycobactin Fe3 unloading" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_fcmcbtt[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_cmcbtt[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_fe3[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_CMLDC" reversible="false" name=" 4-carboxymuconolactone decarboxylase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_2c25dho[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_5odhf2a[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv0771"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_CO2t" reversible="true" name="CO2 transporter via diffusion" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_co2[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_COAt" reversible="true" name="CoA transporter" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_coa[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_coa[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_COBALTt5" reversible="true" name="cobalt transport in/out via permease (no H+)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_cobalt2[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_cobalt2[e]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv1239c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_COCHL" reversible="false" name="cobaltochelatase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_cobalt2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_hgbam[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_co2dam[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2062c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_CODH2r" reversible="true" name="carbon monoxide dehydrogenase / acetyl-CoA synthase 2" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_co[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_fdox[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_fdred[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="2"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_Rv0373c"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv0375c"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv0374c"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_CODH3" reversible="false" name="carbon monoxide dehydrogenase / acetyl-CoA synthase 2" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_adfdOX[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_co[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="2"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adfdRD[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="2"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_Rv0373c"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv0375c"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv0374c"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_COt" reversible="true" name="CO transporter via diffusion" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_co[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_co[e]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_CPC2MT" reversible="false" name="precorrin-2 C20-methyltransferase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_amet[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_copre2[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ahcys[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_copre3[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2066"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_CPC3MT" reversible="false" name="precorrin-3B C17-methyltransferase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_amet[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_copre3[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ahcys[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_copre4[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2066"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_CPC4MT" reversible="false" name="precorrin-4 C11-methyltransferase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_amet[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_copre4[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ahcys[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_copre5[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2071c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_CPC6MT" reversible="false" name="precorrin-6Y C5,15-methyltransferase (decarboxylating)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_amet[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_codhpre6[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ahcys[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_copre8[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2072c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_CPC6R" reversible="false" name="precorrin-6A reductase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_copre6[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadph[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_codhpre6[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadp[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2070c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_CPC8MM" reversible="true" name="precorrin-8X methylmutase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_copre8[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_cobya[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2065"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_CPPPGO" reversible="false" name="coproporphyrinogen oxidase (O2 required)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_cpppg3[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_o2[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_pppg9[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2388c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_CRNabc" reversible="false" name="L-carnitine transport via ABC system" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_crn[e]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_crn[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_Rv3757c"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv3759c"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv3756c"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv3758c"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_CS" reversible="false" name="citrate synthase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_accoa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_oaa[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_cit[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_coa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:or>
            <fbc:geneProductRef fbc:geneProduct="G_Rv0889c"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1131"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv0896"/>
          </fbc:or>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_CTPS1" reversible="false" name="CTP synthase (NH3)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nh4[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_utp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ctp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv1699"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_CTPS2" reversible="false" name="CTP synthase (glutamine)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_gln-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_utp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ctp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_glu-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv1699"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_CYANST" reversible="false" name="Cyanide sulfurtransferase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_cyan[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_tsul[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_so3[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_tcynt[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv3283"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_CYO1a" reversible="false" name="cytochrome-c reductase (ubiquinol: 2 protons)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_ficytc[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_qh2[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_focytc[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_h[e]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_q[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_Rv2195"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv2196"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv2194"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_CYO1b" reversible="false" name="cytochrome-c oxidase (2 protons)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_focytc[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_o2[c]" stoichiometry="0.5"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ficytc[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_Rv2193"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1451"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv3043c"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv2200c"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_CYRDAAT" reversible="false" name="cob(I)yrinic acid a,c-diamide adenosyltransferase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_co1dam[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adcobdam[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pppi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2849c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_CYRDAR" reversible="false" name="cob(II)yrinic acid a,c-diamide reductase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_co2dam[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_nadh[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_co1dam[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nad[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv0306"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_CYSS" reversible="false" name="cysteine synthase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_acser[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2s[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ac[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_cys-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:or>
            <fbc:geneProductRef fbc:geneProduct="G_Rv0848"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv2334"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1336"/>
          </fbc:or>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_CYSTGL" reversible="false" name="cystathionine g-lyase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_cyst-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_2obut[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_cys-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nh4[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_CYSTL" reversible="false" name="cystathionine b-lyase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_cyst-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_hcys-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nh4[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pyr[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv3340"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_CYSTS" reversible="false" name="cystathionine beta-synthase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_hcys-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ser-L[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_cyst-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv1077"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_CYTBD" reversible="false" name="cytochrome oxidase bd (ubiquinol-8: 2 protons)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_o2[c]" stoichiometry="0.5"/>
          <speciesReference constant="true" species="M_q8h2[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[e]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_q8[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1621c"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1622c"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1620c"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1623c"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_CYTBD2" reversible="false" name="cytochrome oxidase bd (menaquinol-8: 2 protons)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_mql8[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_o2[c]" stoichiometry="0.5"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[e]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_mqn8[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1621c"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1622c"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1620c"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1623c"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_CYTD" reversible="false" name="cytidine deaminase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_cytd[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_nh4[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_uri[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv3315c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_CYTDK2" reversible="false" name="cytidine kinase (GTP)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_cytd[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_gtp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_cmp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_gdp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_CYTDt2r" reversible="true" name="cytidine transport in via proton symport, reversible" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_cytd[e]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_cytd[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_CYTK1" reversible="true" name="cytidylate kinase (CMP)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_cmp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_cdp[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv1712"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_CYTK2" reversible="true" name="cytidylate kinase (dCMP)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_dcmp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_dcdp[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv1712"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_Clt" reversible="true" name="chlorideion transport out via diffusion" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_cl[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_cl[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv0143c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_Cuabc" reversible="false" name="Copper transport via ABC system" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_cu2[e]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_cu2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv0103c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_Cut1" reversible="false" name="Copper export via ATPase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_cu2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_cu2[e]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv0103c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_DADA" reversible="false" name="Deoxyadenosine deaminase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_dad-2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_din[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nh4[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_DADK" reversible="true" name="deoxyadenylate kinase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_damp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_dadp[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_DAGK160" reversible="false" name="diacylglycerol kinase (n-C16:0)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_12dgr160[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pa160[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv0499"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_DALAOX" reversible="false" name="D-Alanine Oxidase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_ala-D[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_o2[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h2o2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nh4[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pyr[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv1905c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_DALAt2r" reversible="true" name="D-alanine transport via proton symport" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_ala-D[e]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ala-D[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv1704c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_DAPDC" reversible="false" name="diaminopimelate decarboxylase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_26dap-M[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_lys-L[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv1293"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_DAPE" reversible="true" name="diaminopimelate epimerase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_26dap-LL[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_26dap-M[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2726c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_DASYN160" reversible="false" name="CDP-diacylglycerol synthetase (n-C16:0)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_ctp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pa160[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_cdpdhdecg[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2881c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_DASYN160190" reversible="false" name="CDP-diacylglycerol synthetase (C16:0, C19:0)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_ctp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pa160190[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_cdpc16c19g[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2881c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_DASYN190190" reversible="false" name="CDP-diacylglycerol synthetase (C19:0, C19:0)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_ctp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pa190190[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_cdpc19c19g[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2881c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_DB4PS" reversible="false" name=" 3,4-Dihydroxy-2-butanone-4-phosphate synthase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_ru5p-D[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_db4p[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_for[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_DBTSr" reversible="true" name="dethiobiotin synthase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_dann[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_dtbt[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="3"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv1570"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_DCPDP" reversible="false" name="decaprenyl-diphosphatase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_decdp_tb[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_decd_tb[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2136c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_DCPDPP" reversible="false" name="decaprenylphosphoryl ribose phosphate dephosphatase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_decdpr_tb[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_decdr_tb[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_DCPDPP2" reversible="false" name="decaprenylphosphoryl arabinose phosphate dephosphatase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_decdpa_tb[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_decda_tb[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_DCPDPS" reversible="false" name="Decaprenyl diphosphate synthase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_frdp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ipdp[c]" stoichiometry="7"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_decdp_tb[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="7"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_DCPE" reversible="true" name="decaprenylphosphoryl  ribose, arabinofuranose isomerization" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_decdr_tb[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_decda_tb[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_Rv3791"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv3790"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_DCPT" reversible="false" name="phosphoribose transferase (undecaprenyl phosphate)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_decd_tb[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_prpp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_decdpr_tb[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv3806c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_DCPT2" reversible="false" name="phosphoribose transferase (undecaprenyl phosphate)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_arpp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_decd_tb[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_decdpa_tb[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_DCTPD" reversible="false" name="dCTP deaminase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_dctp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_dutp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nh4[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv0321"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_DCTPD2" reversible="false" name="dCTP deaminase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_ctp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_nh4[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_utp[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv0321"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_DCYTD" reversible="false" name="deoxycytidine deaminase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_dcyt[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_duri[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nh4[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_DDPA" reversible="false" name=" 3-deoxy-D-arabino-heptulosonate 7-phosphate synthetase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_e4p[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pep[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_2dda7p[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2178c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_DESAT16" reversible="false" name="Palmitoyl-CoA desaturase (n-C16:0CoA -&gt; n-C16:1CoA)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadph[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_o2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pmtcoa[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_hdcoa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadp[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv3229c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_DESAT18" reversible="false" name="stearoyl-CoA desaturase (n-C18:0CoA -&gt; n-C18:1CoA)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadph[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_o2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_stcoa[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_nadp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_odecoa[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:or>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1094"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv0824c"/>
          </fbc:or>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_DGC3D" reversible="false" name=" 2-deoxy-D-gluconate 3-dehydrogenase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_2dglcn[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nad[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_3ddgc[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadh[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:or>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1928c"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1714"/>
          </fbc:or>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_DGK1" reversible="true" name="deoxyguanylate kinase (dGMP:ATP)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_dgmp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_dgdp[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv1389"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_DHAD1" reversible="false" name="dihydroxy-acid dehydratase (2,3-dihydroxy-3-methylbutanoate)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_23dhmb[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_3mob[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv0189c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_DHAD2" reversible="false" name="Dihydroxy-acid dehydratase (2,3-dihydroxy-3-methylpentanoate)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_23dhmp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_3mop[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_DHDPRy" reversible="false" name="dihydrodipicolinate reductase (NADPH)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_23dhdp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadph[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_nadp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_thdp[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2773c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_DHDPS" reversible="false" name="dihydrodipicolinate synthase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_aspsa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pyr[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_23dhdp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2753c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_DHFR" reversible="true" name="dihydrofolate reductase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_dhf[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadph[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_nadp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_thf[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2763c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_DHFS" reversible="false" name="dihydrofolate synthase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_dhpt[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_glu-L[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_dhf[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2447c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_DHNAOT" reversible="false" name=" 1,4-dihydroxy-2-naphthoate octaprenyltransferase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_dhna[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_octdp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_2dmmq8[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv0534c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_DHNAOT2" reversible="false" name=" 1,4-dihydroxy-2-naphthoate octaprenyltransferase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_dhna[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_octdp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_2dmmq6[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv0534c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_DHNPA" reversible="false" name="dihydroneopterin aldolase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_dhnpt[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_2ahhmp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_gcald[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv3607c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_DHNPA2" reversible="false" name="dihydroneopterin aldolase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_dhnpt[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_6hmhpt[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_gcald[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv3607c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_DHORD2" reversible="false" name="dihydoorotic acid dehydrogenase (quinone8)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_dhor-S[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_q8[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_orot[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_q8h2[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2139"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_DHORD3" reversible="true" name="dihydroorotic acid dehydrogenase (menaquinone 6)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_dhor-S[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_mqn6[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_mql6[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_orot[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2139"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_DHORD5" reversible="false" name="dihydroorotic acid (menaquinone-8)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_dhor-S[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_mqn8[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_mql8[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_orot[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2139"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_DHORTS" reversible="true" name="dihydroorotase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_dhor-S[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_cbasp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv1381"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_DHPPDA" reversible="false" name="diaminohydroxyphosphoribosylaminopyrimidine deaminase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_25dhpp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_5apru[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nh4[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv1409"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_DHPPDA2" reversible="false" name="diaminohydroxyphosphoribosylaminopryrimidine deaminase (25drapp)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_25drapp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_5apru[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nh4[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv1409"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_DHPS2" reversible="false" name="dihydropteroate synthase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_4abz[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_6hmhptpp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_dhpt[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:or>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1207"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv3608c"/>
          </fbc:or>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_DHQD" reversible="true" name=" 3-dehydroquinate dehydratase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_3dhq[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_3dhsk[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2537c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_DHQS" reversible="false" name=" 3-dehydroquinate synthase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_2dda7p[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_3dhq[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2538c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_DMATT" reversible="false" name="dimethylallyltranstransferase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_dmpp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ipdp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_grdp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv3398c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_DMPPS" reversible="false" name=" 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase (dmpp)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h2mb4p[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadh[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_dmpp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nad[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_DM_atp_c" reversible="false" name="atp demand" fbc:upperFluxBound="cobra_0_bound" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_DNMPPA" reversible="false" name="Dihydroneopterin monophosphate dephosphorylase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_dhpmp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_dhnpt[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_DNTPPA" reversible="false" name="Dihydroneopterin triphosphate pyrophosphatase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_ahdt[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_dhpmp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_DPCOAK" reversible="false" name="dephospho-CoA kinase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_dpcoa[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_coa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv1631"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_DPPS" reversible="false" name="decaprenyl synthase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_frdp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ipdp[c]" stoichiometry="7"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_decdp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="7"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_DPR" reversible="false" name=" 2-dehydropantoate 2-reductase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_2dhp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadph[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_nadp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pant-R[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2573"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_DRPA" reversible="false" name="deoxyribose-phosphate aldolase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_2dr5p[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_acald[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_g3p[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv0478"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_DSERt2r" reversible="true" name="D-serine transport via proton symport" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[e]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ser-D[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ser-D[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv1704c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_DTMPK" reversible="true" name="dTMP kinase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_dtmp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_dtdp[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv3247c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_DURIK1" reversible="false" name="deoxyuridine kinase (ATP:Deoxyuridine)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_duri[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_dump[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_DURIPP" reversible="true" name="deoxyuridine phosphorylase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_duri[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_2dr1p[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ura[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_DUTPDP" reversible="false" name="dUTP diphosphatase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_dutp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_dump[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2697c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_DXPRIi" reversible="false" name=" 1-deoxy-D-xylulose reductoisomerase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_dxyl5p[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadph[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_2me4p[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadp[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2870c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_DXPS" reversible="false" name=" 1-deoxy-D-xylulose 5-phosphate synthase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_g3p[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pyr[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_dxyl5p[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:or>
            <fbc:geneProductRef fbc:geneProduct="G_Rv2682c"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv3379c"/>
          </fbc:or>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_E4PD" reversible="true" name="Erythrose 4-phosphate dehydrogenase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_e4p[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nad[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_4per[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_nadh[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_ECHH_0" reversible="true" name="Ech hydrogenase (no electron transport)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_fdox[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_h2[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_fdred[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="2"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_ENO" reversible="true" name="enolase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_2pg[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pep[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv1023"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_ENTCS" reversible="false" name="enterochelin synthase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_23dhba[c]" stoichiometry="3"/>
          <speciesReference constant="true" species="M_seramp[c]" stoichiometry="3"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_amp[c]" stoichiometry="6"/>
          <speciesReference constant="true" species="M_enter[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="9"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv3214"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_ETHAt" reversible="true" name="ethanolamine transport via diffusion (extracellular)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_etha[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_etha[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_EX_acysbmn(e)" reversible="false" name="acetyl-cystine-bimane exchange" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_acysbmn[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_ala_B(e)" reversible="false" name="beta-Alanine exchange" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_ala-B[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_ala_D(e)" reversible="false" name="D-Alanine exchange" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_ala-D[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_ala_L(e)" reversible="false" name="L-Alanine exchange" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_ala-L[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_arab_D(e)" reversible="false" name="D-Arabinose exchange" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_arab-D[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_arab_L(e)" reversible="false" name="L-Arabinose exchange" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_arab-L[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_arg_L(e)" reversible="false" name="L-Arginine exchange" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_arg-L[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_asn_L(e)" reversible="false" name="L-Asparagine exchange" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_asn-L[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_asp_L(e)" reversible="false" name="L-Aspartate exchange" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_asp-L[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_atp(e)" reversible="false" name="ATP exchange" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_bmn(e)" reversible="false" name="bimane exchange" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_bmn[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_ca2(e)" reversible="true" name="Calcium exchange" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="R_EX_ca2(e)_lower_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_ca2[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_chol(e)" reversible="false" name="Choline exchange" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_chol[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_cit(e)" reversible="true" name="Citrate exchange" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="R_EX_cit(e)_lower_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_cit[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_cl(e)" reversible="true" name="Chloride exchange" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="R_EX_cl(e)_lower_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_cl[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_co2(e)" reversible="false" name="CO2 exchange" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_co2[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_co(e)" reversible="false" name="Carbon monoxide exchange" fbc:upperFluxBound="cobra_0_bound" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_co[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_coa(e)" reversible="false" name="Coenzyme A exchange" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_coa[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_cobalt2(e)" reversible="false" name="Co2+ exchange" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_cobalt2[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_crn(e)" reversible="false" name="L-Carnitine exchange" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_crn[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_cu2(e)" reversible="true" name="Cu2+ exchange" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="R_EX_cu2(e)_lower_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_cu2[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_cytd(e)" reversible="false" name="Cytidine exchange" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_cytd[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_etha(e)" reversible="false" name="Ethanolamine exchange" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_etha[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_fe2(e)" reversible="false" name="Fe2+ exchange" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_fe2[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_fe3(e)" reversible="true" name="Fe3+ exchange" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="R_EX_fe3(e)_lower_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_fe3[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_fum(e)" reversible="false" name="Fumarate exchange" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_fum[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_gal(e)" reversible="false" name="D-Galactose exchange" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_gal[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_glc(e)" reversible="true" name="D-Glucose exchange" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="R_EX_glc(e)_lower_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_glc-D[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_glu_L(e)" reversible="true" name="L-Glutamate exchange" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="R_EX_glu_L(e)_lower_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_glu-L[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_gly(e)" reversible="false" name="Glycine exchange" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_gly[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_glyb(e)" reversible="false" name="Glycine betaine exchange" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_glyb[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_glyc3p(e)" reversible="false" name="Glycerol 3-phosphate exchange" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_glyc3p[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_glyc(e)" reversible="true" name="Glycerol exchange" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="R_EX_glyc(e)_lower_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_glyc[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_gthrd(e)" reversible="false" name="Reduced glutathione exchange" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_gthrd[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_h2(e)" reversible="false" name="H2 exchange" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h2[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_h2co3(e)" reversible="true" name="carbonic acid exchange" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_h2co3[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_h2o(e)" reversible="true" name="H2O exchange" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="R_EX_h2o(e)_lower_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h2o[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_h2s(e)" reversible="false" name="Hydrogen sulfide exchange" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h2s[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_h(e)" reversible="true" name="H+ exchange" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="R_EX_h(e)_lower_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_hdca(e)" reversible="false" name="Hexadecanoate (n-C16:0) exchange" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_hdca[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_his_L(e)" reversible="false" name="L-Histidine exchange" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_his-L[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_id3acald(e)" reversible="false" name="Indole-3-acetaldehyde exchange" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_id3acald[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_ile_L(e)" reversible="false" name="L-Isoleucine exchange" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_ile-L[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_k(e)" reversible="true" name="K+ exchange" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="R_EX_k(e)_lower_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_k[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_lac_L(e)" reversible="false" name="L-Lactate exchange" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_lac-L[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_lcts(e)" reversible="false" name="Lactose exchange" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_lcts[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_leu_L(e)" reversible="false" name="L-Leucine exchange" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_leu-L[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_lys_L(e)" reversible="false" name="L-Lysine exchange" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_lys-L[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_mal_L(e)" reversible="false" name="L-Malate exchange" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_mal-L[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_malt(e)" reversible="false" name="Maltose exchange" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_malt[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_malthp(e)" reversible="false" name="Maltoheptaose exchange" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_malthp[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_meoh(e)" reversible="false" name="methanol exchange" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_meoh[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_met_L(e)" reversible="false" name="L-Methionine exchange" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_met-L[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_mg2(e)" reversible="false" name="Mg exchange" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_mg2[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_na1(e)" reversible="true" name="Sodium exchange" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="R_EX_na1(e)_lower_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_na1[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_nh4(e)" reversible="true" name="Ammonia exchange" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="R_EX_nh4(e)_lower_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_nh4[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_no2(e)" reversible="false" name="Nitrite exchange" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_no2[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_no3(e)" reversible="false" name="Nitrate exchange" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_no3[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_no(e)" reversible="false" name="Nitric oxide exchange" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_no[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_o2(e)" reversible="true" name="O2 exchange" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="R_EX_o2(e)_lower_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_o2[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_ocdca(e)" reversible="false" name="octadecanoate (n-C18:0) exchange" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_ocdca[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_orn(e)" reversible="false" name="Ornithine exchange" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_orn[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_pac(e)" reversible="false" name="Phenylacetic acid exchange" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_pac[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_pdima(e)" reversible="false" name="phthiocerol dimycocerosate A (Mtb) exchange" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_pdima[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_phdca(e)" reversible="false" name="phenol palmitic acid exchange" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_phdca[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_phe_L(e)" reversible="false" name="L-Phenylalanine exchange" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_phe-L[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_pi(e)" reversible="true" name="Phosphate exchange" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="R_EX_pi(e)_lower_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_pi[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_ppa(e)" reversible="false" name="Propionate exchange" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_ppa[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_ppdima(e)" reversible="false" name="phenol phthiocerol dimycocerosate (Mtb) exchange" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_ppdima[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_pro_L(e)" reversible="false" name="L-Proline exchange" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_pro-L[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_pyr(e)" reversible="false" name="Pyruvate exchange" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_pyr[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_rib_D(e)" reversible="false" name="D-Ribose exchange" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_rib-D[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_ser_D(e)" reversible="false" name="D-Serine exchange" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_ser-D[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_ser_L(e)" reversible="false" name="L-Serine exchange" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_ser-L[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_skm(e)" reversible="false" name="Shikimate exchange" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_skm[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_so4(e)" reversible="true" name="Sulfate exchange" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="R_EX_so4(e)_lower_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_so4[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_succ(e)" reversible="false" name="Succinate exchange" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_succ[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_tartr_L(e)" reversible="false" name="L-tartrate exchange" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_tartr-L[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_thr_L(e)" reversible="false" name="L-Threonine exchange" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_thr-L[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_tre(e)" reversible="false" name="Trehalose exchange" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_tre[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_trp_L(e)" reversible="false" name="L-Tryptophan exchange" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_trp-L[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_tsul(e)" reversible="false" name="Thiosulfate exchange" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_tsul[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_ttdca(e)" reversible="false" name="tetradecanoate (n-C14:0) exchange" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_ttdca[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_tyr_L(e)" reversible="false" name="L-Tyrosine exchange" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_tyr-L[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_val_L(e)" reversible="false" name="L-Valine exchange" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_val-L[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_xyl_D(e)" reversible="false" name="D-Xylose exchange" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_xyl-D[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_FACOAE140" reversible="false" name="fatty-acid-CoA thioesterase (tetradecanoate)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_tdcoa[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_coa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ttdca[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv1618"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_FACOAE160" reversible="false" name="fatty-acid-CoA thioesterase (hexadecanoate)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pmtcoa[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_coa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_hdca[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv1618"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_FACOAE180" reversible="false" name="fatty-acid-CoA thioesterase (octadecanoate)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_stcoa[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_coa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ocdca[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv1618"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_FACOAL140" reversible="true" name="fatty-acid--CoA ligase (tetradecanoate)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_coa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ttdca[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_amp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_tdcoa[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:or>
            <fbc:geneProductRef fbc:geneProduct="G_Rv3826"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1529"/>
          </fbc:or>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_FACOAL160" reversible="true" name="fatty-acid--CoA ligase (hexadecanoate)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_coa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_hdca[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_amp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pmtcoa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:or>
            <fbc:geneProductRef fbc:geneProduct="G_Rv2590"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv3826"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1185c"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1529"/>
          </fbc:or>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_FACOAL161" reversible="true" name="fatty-acid--CoA ligase (hexadecenoate)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_coa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_hdcea[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_amp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_hdcoa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:or>
            <fbc:geneProductRef fbc:geneProduct="G_Rv3826"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1529"/>
          </fbc:or>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_FACOAL180" reversible="true" name="fatty-acid--CoA ligase (octadecanoate)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_coa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ocdca[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_amp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_stcoa[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:or>
            <fbc:geneProductRef fbc:geneProduct="G_Rv3826"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1529"/>
          </fbc:or>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_FACOAL181" reversible="true" name="fatty-acid--CoA ligase (octadecenoate)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_coa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ocdcea[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_amp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_odecoa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:or>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1618"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1529"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv3826"/>
          </fbc:or>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_FACOAL200" reversible="true" name="fatty-acid--CoA ligase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_arach[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_coa[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_amp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_arachcoa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:or>
            <fbc:geneProductRef fbc:geneProduct="G_Rv3826"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1529"/>
          </fbc:or>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_FACOAL80" reversible="true" name="fatty-acid--CoA ligase (octanoate)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_coa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_octa[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_amp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_occoa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:or>
            <fbc:geneProductRef fbc:geneProduct="G_Rv3826"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1529"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv2590"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1185c"/>
          </fbc:or>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_FACOALPHDCA" reversible="true" name="fatty-acid--CoA ligase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_coa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_phdca[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_amp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_phdcacoa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_FACOALPREPH" reversible="true" name="fatty-acid--CoA ligase (phthiocerol precursor)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_coa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_prephth[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_amp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_prephthcoa[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2930"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_FAH4" reversible="false" name="Fatty acid hydroxylase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadph[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_o2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_omtta[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_homtta[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadp[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_FAMPL1" reversible="false" name="Fatty Acid Ligase AMP (mycolic acid)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_amp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_meroacidcyc2ACP[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ACP[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_meroacidcyc2AMP[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv3801c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_FAMPL2" reversible="false" name="Fatty Acid Ligase AMP (mycolic acid)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_amp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_mmeroacidcyc2ACP[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ACP[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_mmeroacidcyc2AMP[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv3801c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_FAMPL3" reversible="false" name="Fatty Acid Ligase AMP (mycolic acid)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_amp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_kmeroacidcyc2ACP[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ACP[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_kmeroacidcyc2AMP[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv3801c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_FAMPL4" reversible="false" name="Fatty Acid Ligase AMP (mycolic acid)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_amp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_mmmeroacidcyc1ACP[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ACP[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_mmmeroacidcyc1AMP[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv3801c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_FAMPL5" reversible="false" name="Fatty Acid Ligase AMP (mycolic acid)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_amp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_mkmeroacidcyc1ACP[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ACP[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_mkmeroacidcyc1AMP[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv3801c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_FAO1" reversible="false" name="Fatty acid oxidation (tetradecanoate)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_coa[c]" stoichiometry="7"/>
          <speciesReference constant="true" species="M_fad[c]" stoichiometry="6"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="6"/>
          <speciesReference constant="true" species="M_nad[c]" stoichiometry="6"/>
          <speciesReference constant="true" species="M_ttdca[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_accoa[c]" stoichiometry="7"/>
          <speciesReference constant="true" species="M_amp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_fadh2[c]" stoichiometry="6"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="6"/>
          <speciesReference constant="true" species="M_nadh[c]" stoichiometry="6"/>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1323"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv0468"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv0860"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv0859"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_FAO10" reversible="false" name="Fatty acid oxidation (octadecenoate)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_coa[c]" stoichiometry="9"/>
          <speciesReference constant="true" species="M_fad[c]" stoichiometry="7"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="8"/>
          <speciesReference constant="true" species="M_nad[c]" stoichiometry="8"/>
          <speciesReference constant="true" species="M_ocdcea[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_accoa[c]" stoichiometry="9"/>
          <speciesReference constant="true" species="M_amp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_fadh2[c]" stoichiometry="7"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="8"/>
          <speciesReference constant="true" species="M_nadh[c]" stoichiometry="8"/>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1323"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv0468"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv0860"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv0859"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_FAO11" reversible="false" name="Fatty acid oxidation (n-C16:1)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_coa[c]" stoichiometry="8"/>
          <speciesReference constant="true" species="M_fad[c]" stoichiometry="6"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="7"/>
          <speciesReference constant="true" species="M_hdcea[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nad[c]" stoichiometry="7"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_accoa[c]" stoichiometry="8"/>
          <speciesReference constant="true" species="M_amp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_fadh2[c]" stoichiometry="6"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="7"/>
          <speciesReference constant="true" species="M_nadh[c]" stoichiometry="7"/>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1323"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv0468"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv0860"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv0859"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_FAO2" reversible="false" name="Fatty acid oxidation (n-C16:0)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_coa[c]" stoichiometry="8"/>
          <speciesReference constant="true" species="M_fad[c]" stoichiometry="7"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="7"/>
          <speciesReference constant="true" species="M_hdca[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nad[c]" stoichiometry="7"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_accoa[c]" stoichiometry="8"/>
          <speciesReference constant="true" species="M_amp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_fadh2[c]" stoichiometry="7"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="7"/>
          <speciesReference constant="true" species="M_nadh[c]" stoichiometry="7"/>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1323"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv0468"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv0860"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv0859"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_FAO3" reversible="false" name="Fatty acid oxidation (octadecanoate)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_coa[c]" stoichiometry="9"/>
          <speciesReference constant="true" species="M_fad[c]" stoichiometry="8"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="8"/>
          <speciesReference constant="true" species="M_nad[c]" stoichiometry="8"/>
          <speciesReference constant="true" species="M_ocdca[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_accoa[c]" stoichiometry="9"/>
          <speciesReference constant="true" species="M_amp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_fadh2[c]" stoichiometry="8"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="8"/>
          <speciesReference constant="true" species="M_nadh[c]" stoichiometry="8"/>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1323"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv0468"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv0860"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv0859"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_FAS100" reversible="false" name="fatty acid synthase (n-C10:0)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="3"/>
          <speciesReference constant="true" species="M_malcoa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadph[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_octa[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_coa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_dca[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadp[c]" stoichiometry="2"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1350"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv2947c"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1484"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv2524c"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_FAS120" reversible="false" name="fatty acid synthase (n-C12:0)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_dca[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="3"/>
          <speciesReference constant="true" species="M_malcoa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadph[c]" stoichiometry="2"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_coa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ddca[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadp[c]" stoichiometry="2"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1350"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv2947c"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1484"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv2524c"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_FAS140" reversible="false" name="fatty acid synthase (n-C14:0)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_ddca[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="3"/>
          <speciesReference constant="true" species="M_malcoa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadph[c]" stoichiometry="2"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_coa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadp[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_ttdca[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:or>
            <fbc:geneProductRef fbc:geneProduct="G_Rv0533c"/>
            <fbc:and>
              <fbc:geneProductRef fbc:geneProduct="G_Rv1350"/>
              <fbc:geneProductRef fbc:geneProduct="G_Rv2947c"/>
              <fbc:geneProductRef fbc:geneProduct="G_Rv1484"/>
              <fbc:geneProductRef fbc:geneProduct="G_Rv2524c"/>
            </fbc:and>
          </fbc:or>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_FAS160" reversible="false" name="fatty acid synthase (n-C16:0)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="3"/>
          <speciesReference constant="true" species="M_malcoa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadph[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_ttdca[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_coa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_hdca[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadp[c]" stoichiometry="2"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1350"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv2947c"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1484"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv2524c"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_FAS161" reversible="false" name="fatty acid synthase (n-C16:1)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="4"/>
          <speciesReference constant="true" species="M_malcoa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadph[c]" stoichiometry="3"/>
          <speciesReference constant="true" species="M_o2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ttdca[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_coa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="3"/>
          <speciesReference constant="true" species="M_hdcea[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadp[c]" stoichiometry="3"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1350"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv2947c"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1484"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv2524c"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_FAS180" reversible="false" name="fatty acid synthase (n-C18:0)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="3"/>
          <speciesReference constant="true" species="M_hdca[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_malcoa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadph[c]" stoichiometry="2"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_coa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadp[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_ocdca[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1350"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv2947c"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1484"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv2524c"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_FAS181" reversible="false" name="fatty acid synthase (n-C18:1)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="4"/>
          <speciesReference constant="true" species="M_hdca[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_malcoa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadph[c]" stoichiometry="3"/>
          <speciesReference constant="true" species="M_o2[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_coa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="3"/>
          <speciesReference constant="true" species="M_nadp[c]" stoichiometry="3"/>
          <speciesReference constant="true" species="M_ocdcea[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1350"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv2947c"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1484"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv2524c"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_FAS200" reversible="false" name="fatty acid synthase (n-C20:0)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="3"/>
          <speciesReference constant="true" species="M_malcoa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadph[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_ocdca[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_arach[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_coa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadp[c]" stoichiometry="2"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1350"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv2947c"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1484"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv2524c"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_FAS240_L" reversible="false" name="fatty acid synthase (n-C24:0), lumped reaction" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="9"/>
          <speciesReference constant="true" species="M_malcoa[c]" stoichiometry="3"/>
          <speciesReference constant="true" species="M_nadph[c]" stoichiometry="6"/>
          <speciesReference constant="true" species="M_ocdca[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="3"/>
          <speciesReference constant="true" species="M_coa[c]" stoichiometry="3"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="3"/>
          <speciesReference constant="true" species="M_nadp[c]" stoichiometry="6"/>
          <speciesReference constant="true" species="M_ttc[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1350"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv2947c"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1484"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv2524c"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_FAS260" reversible="false" name="fatty acid synthase (n-C26:0)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="3"/>
          <speciesReference constant="true" species="M_malcoa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadph[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_ttc[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_coa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_hexc[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadp[c]" stoichiometry="2"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1350"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv2947c"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1484"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv2524c"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_FAS80_L" reversible="false" name="fatty acid synthase (n-C8:0), lumped reaction" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_accoa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="8"/>
          <speciesReference constant="true" species="M_malcoa[c]" stoichiometry="3"/>
          <speciesReference constant="true" species="M_nadph[c]" stoichiometry="6"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="3"/>
          <speciesReference constant="true" species="M_coa[c]" stoichiometry="4"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_nadp[c]" stoichiometry="6"/>
          <speciesReference constant="true" species="M_octa[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1350"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv2947c"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1484"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv2524c"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_FASPHDCA" reversible="false" name="fatty-acyl-ACP synthase (phdca)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_4hbzACP[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="24"/>
          <speciesReference constant="true" species="M_malACP[c]" stoichiometry="8"/>
          <speciesReference constant="true" species="M_nadph[c]" stoichiometry="16"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ACP[c]" stoichiometry="8"/>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="8"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="8"/>
          <speciesReference constant="true" species="M_nadp[c]" stoichiometry="16"/>
          <speciesReference constant="true" species="M_phdcaACP[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_FASm1601" reversible="false" name="fatty acid synthase - methyl octadecanoic acid" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="3"/>
          <speciesReference constant="true" species="M_hdca[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_mmcoa-S[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadph[c]" stoichiometry="2"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_coa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_m1ocdca[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadp[c]" stoichiometry="2"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1663"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1662"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_FASm180" reversible="false" name="fatty acid synthase - tuberculostearic acid" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="15"/>
          <speciesReference constant="true" species="M_malcoa[c]" stoichiometry="4"/>
          <speciesReference constant="true" species="M_mmcoa-S[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadph[c]" stoichiometry="10"/>
          <speciesReference constant="true" species="M_octa[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="5"/>
          <speciesReference constant="true" species="M_coa[c]" stoichiometry="5"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="5"/>
          <speciesReference constant="true" species="M_mocdca[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadp[c]" stoichiometry="10"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1663"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1662"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_FASm1801" reversible="false" name="fatty acid synthase - dimethyl arachic acid" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="3"/>
          <speciesReference constant="true" species="M_m1ocdca[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_mmcoa-S[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadph[c]" stoichiometry="2"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_coa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_dmarach[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadp[c]" stoichiometry="2"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1663"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1662"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_FASm2001" reversible="false" name="fatty acid synthase - tri-methyl behenic acid" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_dmarach[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="3"/>
          <speciesReference constant="true" species="M_mmcoa-S[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadph[c]" stoichiometry="2"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_coa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadp[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_tmbhn[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1663"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1662"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_FASm2002" reversible="false" name="fatty acid synthase - methyl-arachidic acid" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="3"/>
          <speciesReference constant="true" species="M_mmcoa-S[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadph[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_ocdca[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_coa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_marach[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadp[c]" stoichiometry="2"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1663"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1662"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_FASm220" reversible="false" name="fatty acid synthase - methyl-behenic acid" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_arach[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="3"/>
          <speciesReference constant="true" species="M_mmcoa-S[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadph[c]" stoichiometry="2"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_coa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_mbhn[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadp[c]" stoichiometry="2"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2940c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_FASm2201" reversible="false" name="fatty acid synthase - tri-methyl lignoceric acid" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="3"/>
          <speciesReference constant="true" species="M_mmcoa-S[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadph[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_tmbhn[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_coa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadp[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_tamlgnc[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2940c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_FASm2202" reversible="false" name="fatty acid synthase - di-methyl-behenic acid" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="3"/>
          <speciesReference constant="true" species="M_marach[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_mmcoa-S[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadph[c]" stoichiometry="2"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_coa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_dmbhn[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadp[c]" stoichiometry="2"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2940c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_FASm240" reversible="false" name="fatty acid synthase - di-methyl lignoceric acid" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="3"/>
          <speciesReference constant="true" species="M_mbhn[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_mmcoa-S[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadph[c]" stoichiometry="2"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_coa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_dmlgnc[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadp[c]" stoichiometry="2"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2940c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_FASm2401" reversible="false" name="fatty acid synthase - penta-methyl hexacosanoic acid" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="3"/>
          <speciesReference constant="true" species="M_mmcoa-S[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadph[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_tamlgnc[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_coa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadp[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_pmhexc[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2940c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_FASm2402" reversible="false" name="fatty acid synthase - tri-methyl-lignoceric acid" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_dmbhn[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="3"/>
          <speciesReference constant="true" species="M_mmcoa-S[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadph[c]" stoichiometry="2"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_coa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadp[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_tmlgnc[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2940c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_FASm260" reversible="false" name="fatty acid synthase - tri-methyl cerotic acid" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_dmlgnc[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="3"/>
          <speciesReference constant="true" species="M_mmcoa-S[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadph[c]" stoichiometry="2"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_coa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadp[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_tmhexc[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2940c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_FASm2601" reversible="false" name="fatty acid synthase - hexa-methyl octacosanoic acid" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="3"/>
          <speciesReference constant="true" species="M_mmcoa-S[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadph[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_pmhexc[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_coa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_hmocta[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadp[c]" stoichiometry="2"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2940c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_FASm2602" reversible="false" name="fatty acid synthase - tetra-methyl hexacosanoic acid" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="3"/>
          <speciesReference constant="true" species="M_mmcoa-S[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadph[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_tmlgnc[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_coa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadp[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_tamhexc[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2940c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_FASm280" reversible="false" name="fatty acid synthase - tetra-methyl octacosanoic acid" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="3"/>
          <speciesReference constant="true" species="M_mmcoa-S[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadph[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_tmhexc[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_coa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadp[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_tamocta[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2940c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_FASm2801" reversible="false" name="fatty acid synthase - hepta-methyl triacontanoic acid" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="3"/>
          <speciesReference constant="true" species="M_hmocta[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_mmcoa-S[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadph[c]" stoichiometry="2"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_coa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_hpmtria[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadp[c]" stoichiometry="2"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2940c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_FASm2802" reversible="false" name="fatty acid synthase - penta-methyl octacosanoic acid" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="3"/>
          <speciesReference constant="true" species="M_mmcoa-S[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadph[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_tamhexc[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_coa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadp[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_pmocta[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2940c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_FASm300" reversible="false" name="fatty acid synthase - hexa-methyl triacontanoic acid" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="3"/>
          <speciesReference constant="true" species="M_mmcoa-S[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadph[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_pmocta[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_coa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_hmtria[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadp[c]" stoichiometry="2"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2940c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_FASm3001" reversible="false" name="fatty acid synthase - octa-methyl dotriacontanoic acid" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="3"/>
          <speciesReference constant="true" species="M_hpmtria[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_mmcoa-S[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadph[c]" stoichiometry="2"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_coa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadp[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_omdtria[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2940c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_FASm320" reversible="false" name="fatty acid synthase - hepta-methyl dotriacontanoic acid" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="3"/>
          <speciesReference constant="true" species="M_hmtria[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_mmcoa-S[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadph[c]" stoichiometry="2"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_coa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_hpmdtria[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadp[c]" stoichiometry="2"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2940c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_FASm340" reversible="false" name="fatty acid synthase - octa-methyl tetracontatricosanoic acid" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="3"/>
          <speciesReference constant="true" species="M_hpmdtria[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_mmcoa-S[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadph[c]" stoichiometry="2"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_coa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadp[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_omtta[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2940c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_FBA" reversible="true" name="fructose-bisphosphate aldolase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_fdp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_dhap[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_g3p[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv0363c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_FBP" reversible="false" name="fructose-bisphosphatase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_fdp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_f6p[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv1099c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_FCLPA" reversible="true" name="L-fuculose 1-phosphate aldolase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_fc1p[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_dhap[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_lald-L[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv0727c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_FCLT" reversible="false" name="Ferrochelatase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_fe2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ppp9[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_pheme[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv1485"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_FCLT2" reversible="false" name="Ferrochelatase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_fmcbtt[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ppp9[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_mcbtt[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pheme[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_FCOAH2" reversible="false" name="formyl coa hydrolase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_forcoa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_coa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_for[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2605c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_FDH" reversible="false" name="formate dehydrogenase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_for[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nad[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadh[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_Rv2899c"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv2900c"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_FE2abc" reversible="false" name="iron (II) transport via ABC system" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_fe2[e]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_fe2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1349"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1348"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_FE3Ri" reversible="false" name="Fe(III) reduction" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_fadh2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_fe3[c]" stoichiometry="2"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_fad[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_fe2[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="2"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_FE3abc" reversible="false" name="iron (III) transport via ABC system" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_fe3[e]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_fe3[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1349"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1348"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_FETRANS" reversible="true" name="Mycobactin Fe transfer" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_fmcbtt[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_fe2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_mcbtt[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_FHL" reversible="false" name="Formate-hydrogen lyase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_for[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv0084"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_FMETTRS" reversible="false" name="Methionyl-tRNA formyltransferase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_10fthf[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_mettrna[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_fmettrna[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_thf[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv1406"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_FMNAT" reversible="false" name="FMN adenylyltransferase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_fmn[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_fad[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2786c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_FOLD3" reversible="false" name="dihydropteroate synthase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_2ahhmd[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_4abz[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_dhpt[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:or>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1207"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv3608c"/>
          </fbc:or>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_FOLR2" reversible="false" name="folate reductase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_fol[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadph[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_dhf[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadp[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2763c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_FOMETR" reversible="true" name="aminomethyltransferase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_5fthf[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_methf[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2211c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_FORMCOAL" reversible="true" name="formyl-coa--CoA ligase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_coa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_for[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_amp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_forcoa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_FRD" reversible="false" name="fumarate reductase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_fadh2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_fum[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_fad[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_succ[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1555"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1552"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1553"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1554"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_FRD2" reversible="false" name="fumarate reductase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_fum[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_mql8[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_mqn8[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_succ[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:or>
            <fbc:and>
              <fbc:geneProductRef fbc:geneProduct="G_Rv3319"/>
              <fbc:geneProductRef fbc:geneProduct="G_Rv3317"/>
              <fbc:geneProductRef fbc:geneProduct="G_Rv3316"/>
              <fbc:geneProductRef fbc:geneProduct="G_Rv3318"/>
            </fbc:and>
            <fbc:and>
              <fbc:geneProductRef fbc:geneProduct="G_Rv0248c"/>
              <fbc:geneProductRef fbc:geneProduct="G_Rv3317"/>
              <fbc:geneProductRef fbc:geneProduct="G_Rv3316"/>
              <fbc:geneProductRef fbc:geneProduct="G_Rv3318"/>
            </fbc:and>
            <fbc:and>
              <fbc:geneProductRef fbc:geneProduct="G_Rv3317"/>
              <fbc:geneProductRef fbc:geneProduct="G_Rv3316"/>
              <fbc:geneProductRef fbc:geneProduct="G_Rv0247c"/>
              <fbc:geneProductRef fbc:geneProduct="G_Rv3318"/>
            </fbc:and>
          </fbc:or>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_FRD3" reversible="false" name="fumarate reductase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_2dmmql8[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_fum[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_2dmmq8[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_succ[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:or>
            <fbc:and>
              <fbc:geneProductRef fbc:geneProduct="G_Rv3319"/>
              <fbc:geneProductRef fbc:geneProduct="G_Rv3317"/>
              <fbc:geneProductRef fbc:geneProduct="G_Rv3316"/>
              <fbc:geneProductRef fbc:geneProduct="G_Rv3318"/>
            </fbc:and>
            <fbc:and>
              <fbc:geneProductRef fbc:geneProduct="G_Rv0248c"/>
              <fbc:geneProductRef fbc:geneProduct="G_Rv3317"/>
              <fbc:geneProductRef fbc:geneProduct="G_Rv3316"/>
              <fbc:geneProductRef fbc:geneProduct="G_Rv3318"/>
            </fbc:and>
            <fbc:and>
              <fbc:geneProductRef fbc:geneProduct="G_Rv3317"/>
              <fbc:geneProductRef fbc:geneProduct="G_Rv3316"/>
              <fbc:geneProductRef fbc:geneProduct="G_Rv0247c"/>
              <fbc:geneProductRef fbc:geneProduct="G_Rv3318"/>
            </fbc:and>
          </fbc:or>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_FRD5" reversible="true" name="fumarate reductase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_fum[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_mql6[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_mqn6[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_succ[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1555"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1552"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1553"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1554"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_FRDO2r" reversible="true" name="ferredoxin oxidoreductase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_adfdRD[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadp[c]" stoichiometry="2"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adfdOX[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadph[c]" stoichiometry="2"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:or>
            <fbc:geneProductRef fbc:geneProduct="G_Rv3106"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv0886"/>
          </fbc:or>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_FRDO3r" reversible="true" name="ferredoxin oxidoreductase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_adfdRD[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nad[c]" stoichiometry="2"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adfdOX[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadh[c]" stoichiometry="2"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:or>
            <fbc:geneProductRef fbc:geneProduct="G_Rv3106"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv0886"/>
          </fbc:or>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_FRDOr" reversible="true" name="ferredoxin oxidoreductase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_fdxrd[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_fdxox[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadph[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_Rv2454c"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv2455c"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_FRRPPDIMAS" reversible="false" name="fucose rhamnose rhamnose phenol phthiocerol dimycocerosate synthesis" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_gdpfuc[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_rrppdima[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_frrppdima[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_gdp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2957"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_FTHFCL" reversible="false" name=" 5-formethyltetrahydrofolate cyclo-ligase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_5fthf[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_methf[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_FTHFD" reversible="false" name="formyltetrahydrofolate deformylase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_10fthf[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_for[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_thf[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2964"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_FTHFL" reversible="true" name="formate-tetrahydrofolate ligase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_for[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_thf[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_10fthf[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_FUM" reversible="true" name="fumarase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_fum[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_mal-L[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv1098c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_FUMt2r" reversible="true" name="fumarate reversible transport via symport" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_fum[e]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_fum[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2443"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_G16MTM1" reversible="false" name="Glycolipid 1,6-alpha-D-mannosyltransferase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_gdpmann[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ptd1ino160190[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_PIM1[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_gdp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2610c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_G16MTM10" reversible="false" name="Glycolipid 16-alpha-D-mannosyltransferase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_PIM5[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_gdpmann[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_PIM6[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_gdp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_G16MTM2" reversible="false" name="Glycolipid 16-alpha-D-mannosyltransferase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_Ac1PIM1[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_gdpmann[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_Ac1PIM2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_gdp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv0557"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_G16MTM4" reversible="false" name="Glycolipid 16-alpha-D-mannosyltransferase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_Ac1PIM2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_decdman1p_tb[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_Ac1PIM3[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_decd_tb[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_G16MTM5" reversible="false" name="Glycolipid 16-alpha-D-mannosyltransferase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_Ac1PIM3[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_decdman1p_tb[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_Ac1PIM4[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_decd_tb[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_G16MTM6" reversible="false" name="Glycolipid 16-alpha-D-mannosyltransferase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_PIM1[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_gdpmann[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_PIM2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_gdp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_G16MTM7" reversible="false" name="Glycolipid 16-alpha-D-mannosyltransferase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_PIM2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_gdpmann[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_PIM3[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_gdp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_G16MTM8" reversible="false" name="Glycolipid 16-alpha-D-mannosyltransferase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_PIM3[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_gdpmann[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_PIM4[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_gdp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_G16MTM9" reversible="false" name="Glycolipid 16-alpha-D-mannosyltransferase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_PIM4[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_gdpmann[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_PIM5[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_gdp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_G1PACT" reversible="false" name="glucosamine-1-phosphate N-acetyltransferase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_accoa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_gam1p[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_acgam1p[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_coa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv1018c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_G1PTT" reversible="false" name="glucose-1-phosphate thymidylyltransferase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_dttp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_g1p[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_dtdpglu[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv0334"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_G1SATi" reversible="false" name="glutamate-1-semialdehyde aminotransferase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_glu1sa[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_5aop[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv0524"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_G3PAT160" reversible="false" name="glycerol-3-phosphate acyltransferase (C16:0)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_glyc3p[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_palmACP[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_1hdecg3p[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ACP[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv1551"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_G3PAT190" reversible="false" name="glycerol-3-phosphate acyltransferase (C19:0)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_glyc3p[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_mstrACP[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_1msg3p[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ACP[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv1551"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_G3PD1" reversible="true" name="glycerol-3-phosphate dehydrogenase (NAD)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_glyc3p[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nad[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_dhap[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadh[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:or>
            <fbc:geneProductRef fbc:geneProduct="G_Rv3302c"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv0564c"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv2982c"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv2249c"/>
          </fbc:or>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_G5SADs" reversible="false" name="L-glutamate 5-semialdehyde dehydratase (spontaneous)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_glu5sa[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_1pyr5c[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_G5SD" reversible="false" name="glutamate-5-semialdehyde dehydrogenase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_glu5p[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadph[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_glu5sa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2427c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_G5SD2" reversible="false" name="glutamate-5-semialdehyde dehydrogenase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_glu5p[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadh[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_glu5sa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nad[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2427c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_G6PDH2" reversible="false" name="glucose 6-phosphate dehydrogenase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_g6p[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_6pgl[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadph[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:or>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1447c"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1121"/>
          </fbc:or>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_GALFT" reversible="false" name="galactofuranose transferse (M tb)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ragund[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_udpgalfur[c]" stoichiometry="30"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_galfragund[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="30"/>
          <speciesReference constant="true" species="M_udp[c]" stoichiometry="30"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv3808c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_GALKr" reversible="true" name="galactokinase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_gal[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_gal1p[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv0620"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_GALT" reversible="true" name="galactose-1-phosphate uridylyltransferase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_gal1p[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_utp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_udpgal[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_Rv0618"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv0619"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_GALUi" reversible="false" name="UTP-glucose-1-phosphate uridylyltransferase (irreversible)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_g1p[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_utp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_udpg[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv0993"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_GALt2" reversible="false" name="D-galactose transport in via proton symport" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_gal[e]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_gal[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv3331"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_GAPD" reversible="true" name="glyceraldehyde-3-phosphate dehydrogenase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_g3p[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nad[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_13dpg[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadh[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv1436"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_GARFT" reversible="true" name="phosphoribosylglycinamide formyltransferase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_10fthf[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_gar[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_fgam[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_thf[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:or>
            <fbc:geneProductRef fbc:geneProduct="G_Rv0389"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv0956"/>
          </fbc:or>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_GCC2" reversible="false" name="glycine-cleavage system (lipoamide) irreversible" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_alpam[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_thf[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_dhlam[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_mlthf[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nh4[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2211c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_GCCa" reversible="false" name="glycine-cleavage complex" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_gly[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_lpro[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_alpro[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv1832"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_GCCb" reversible="false" name="glycine cleavage complex" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_alpro[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_thf[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_dhlpro[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_mlthf[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nh4[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2211c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_GCCc" reversible="false" name="glycine-cleavage complex" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_dhlpro[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nad[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_lpro[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadh[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_Rv3303c"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv0794c"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_GF6PTAr" reversible="true" name="Glutamine-fructose-6-phosphate transaminase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_f6p[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_gln-L[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_gam6p[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_glu-L[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv3436c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_GFUCS" reversible="false" name="GDP-L-fucose synthase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_gdpddman[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadph[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_gdpfuc[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadp[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv1512"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_GGLUCT2" reversible="false" name="gamma-glutamylcyclotransferase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_gluala[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_5oxpro[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ala-L[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_GHMT2" reversible="false" name="glycine hydroxymethyltransferase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_ser-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_thf[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_gly[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_mlthf[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:or>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1093"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv0070c"/>
          </fbc:or>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_GK1" reversible="true" name="guanylate kinase (GMP:ATP)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_gmp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_gdp[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv1389"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_GLCP" reversible="false" name="glycogen phosphorylase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_glycogen[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_g1p[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv1328"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_GLCS1" reversible="false" name="glycogen synthase (ADPGlc)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_adpglc[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_glycogen[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_GLCabc" reversible="false" name="D-glucose transport via ABC system" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_glc-D[e]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_glc-D[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1237"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1236"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1238"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_GLGC" reversible="false" name="glucose-1-phosphate adenylyltransferase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_g1p[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adpglc[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv1213"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_GLNS" reversible="false" name="glutamine synthetase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_glu-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nh4[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_gln-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_Rv2222c"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1878"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv2860c"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv2220"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_GLNSP1" reversible="false" name="glutamine synthetase (uaaAgld)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nh4[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_uaaAgla[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_uaaAgtla[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_Rv2222c"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1878"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv2860c"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv2220"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_GLNSP2" reversible="false" name="glutamine synthetase (uaaGgla)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nh4[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_uaaGgla[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_uaaGgtla[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_Rv2222c"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1878"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv2860c"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv2220"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_GLNSP3" reversible="false" name="glutamine synthetase (uaagmda)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nh4[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_uaagmda[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_uaagtmda[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_Rv2222c"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1878"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv2860c"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv2220"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_GLU5K" reversible="false" name="glutamate 5-kinase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_glu-L[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_glu5p[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2439c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_GLUCYS" reversible="false" name="gamma-glutamylcysteine synthetase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_cys-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_glu-L[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_glucys[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv3704c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_GLUDC" reversible="false" name="Glutamate Decarboxylase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_glu-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_4abut[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv3432c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_GLUDx" reversible="true" name="glutamate dehydrogenase (NAD)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_glu-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nad[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_akg[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadh[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nh4[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2476c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_GLUPRT" reversible="false" name="glutamine phosphoribosyldiphosphate amidotransferase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_gln-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_prpp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_glu-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pram[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:or>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1602"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv0808"/>
          </fbc:or>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_GLUR" reversible="true" name="glutamate racemase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_glu-D[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_glu-L[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv1338"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_GLUSy" reversible="false" name="glutamate synthase (NADPH)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_akg[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_gln-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadph[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_glu-L[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_nadp[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_Rv3859c"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv3858c"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_GLUTRR" reversible="false" name="glutamyl-tRNA reductase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_glutrna[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadph[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_glu1sa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_trnaglu[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv0509"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_GLUt2r" reversible="true" name="L-glutamate transport via proton symport, reversible" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_glu-L[e]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_glu-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_GLXO1" reversible="false" name="glyoxylate oxidase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_glx[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nad[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_nadh[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_oxa[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_GLYBabc" reversible="false" name="Glycine betaine transport via ABC system" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_glyb[e]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_glyb[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_Rv3757c"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv3759c"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv3756c"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv3758c"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_GLYC3Pabc" reversible="false" name="sn-Glycerol 3-phosphate transport via ABC system" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_glyc3p[e]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_glyc3p[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_Rv2833c"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv2834c"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv2832c"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv2835c"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_GLYCK" reversible="false" name="glycerate kinase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_glyc-R[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_3pg[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2205c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_GLYCL" reversible="false" name="Glycine Cleavage System" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_gly[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nad[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_thf[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_mlthf[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadh[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nh4[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv1826"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_GLYCTO1" reversible="false" name="Glycolate oxidase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_glyclt[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_o2[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_glx[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o2[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv1257c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_GLYCTO2" reversible="false" name="Glycolate oxidase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_glyclt[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_q8[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_glx[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_q8h2[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv1257c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_GLYCTO3" reversible="false" name="Glycolate oxidase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_glyclt[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_mqn8[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_glx[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_mql8[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv1257c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_GLYCTO4" reversible="false" name="Glycolate oxidase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_2dmmq8[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_glyclt[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_2dmmql8[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_glx[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv1257c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_GLYCt" reversible="true" name="glycerol transport via channel" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_glyc[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_glyc[e]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_GLYK" reversible="false" name="glycerol kinase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_glyc[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_glyc3p[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv3696c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_GLYt2r" reversible="true" name="glycine reversible transport via proton symport" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_gly[e]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_gly[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv1704c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_GMAND" reversible="false" name="GDP-D-mannose dehydratase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_gdpmann[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_gdpddman[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:or>
            <fbc:geneProductRef fbc:geneProduct="G_Rv0112"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1511"/>
          </fbc:or>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_GMPS2" reversible="false" name="GMP synthase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_gln-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_xmp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_amp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_glu-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_gmp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv3396c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_GMT1" reversible="false" name="gdp mannosyl phosphate transferase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_decd_tb[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_gdpmann[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_decdman1p_tb[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_gdp[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2051c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_GMT2" reversible="false" name="gdp mannosyl phosphate transferase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_gdpmann[c]" stoichiometry="3"/>
          <speciesReference constant="true" species="M_harab-D[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_gdp[c]" stoichiometry="3"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="3"/>
          <speciesReference constant="true" species="M_mharab-D[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2051c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_GND" reversible="false" name="phosphogluconate dehydrogenase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_6pgc[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadph[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ru5p-D[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:or>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1844c"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1122"/>
          </fbc:or>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_GPDDA2" reversible="false" name="Glycerophosphodiester phosphodiesterase (Glycerophosphoethanolamine)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_g3pe[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_etha[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_glyc3p[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:or>
            <fbc:geneProductRef fbc:geneProduct="G_Rv0317c"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv3842c"/>
          </fbc:or>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_GRTT" reversible="false" name="geranyltranstransferase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_grdp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ipdp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_frdp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv1086"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_GSNK" reversible="false" name="guanosine kinase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_gsn[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_gmp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_GTHOr" reversible="true" name="glutathione oxidoreductase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_gthox[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadph[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_gthrd[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_nadp[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2855"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_GTHRDt2" reversible="false" name="glutathione transport" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_gthrd[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_gthrd[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_GTHS" reversible="false" name="glutathione synthetase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_glucys[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_gly[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_gthrd[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_GTMLT" reversible="false" name="g-glutamyltransferase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_ala-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_gthrd[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_cgly[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_gluala[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_Rv0773c"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv2394"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_GTPCI" reversible="false" name="GTP cyclohydrolase I" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_gtp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ahdt[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_for[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv3609c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_GTPCII" reversible="false" name="GTP cyclohydrolase II" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_gtp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="3"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_25dhpp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_for[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:or>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1415"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1940"/>
          </fbc:or>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_GTPCII2" reversible="false" name="GTP cyclohydrolase II (25drapp)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_gtp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="3"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_25drapp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_for[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_GTPDPK" reversible="false" name="GTP diphosphokinase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_gtp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_amp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_gdptp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2583c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_GTPH1" reversible="false" name="GTP diphosphohydrolase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_gtp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="2"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_gmp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="2"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2583c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_GUACYC" reversible="false" name="guanylate cyclase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_gtp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_35cgmp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2435c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_GUAD" reversible="false" name="guanine deaminase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_gua[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_nh4[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_xan[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_GUAPRT" reversible="false" name="guanine phosphoribosyltransferase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_gua[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_prpp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_gmp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_H2CO3D" reversible="true" name="carboxylic acid dissociation" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h2co3[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:or>
            <fbc:geneProductRef fbc:geneProduct="G_Rv3273"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv3588c"/>
          </fbc:or>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_H2CO3TP" reversible="true" name="H2CO3 transport" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_h2co3[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h2co3[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_H2Ot" reversible="true" name="H2O transport via diffusion" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_h2o[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_H2St1" reversible="false" name="h2s transport" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h2s[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h2s[e]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_H2td" reversible="true" name="hydrogen transport" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_h2[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h2[e]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_HAS" reversible="false" name="hexa-arabinofuranoside synthesis" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_arab-D[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_decda_tb[c]" stoichiometry="5"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_decd_tb[c]" stoichiometry="5"/>
          <speciesReference constant="true" species="M_harab-D[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_HCO3E" reversible="true" name="HCO3 equilibration reaction" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_hco3[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:or>
            <fbc:geneProductRef fbc:geneProduct="G_Rv3273"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv3588c"/>
          </fbc:or>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_HCYSMT" reversible="false" name="homocysteine S-methyltransferase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_amet[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_hcys-L[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ahcys[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_met-L[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:or>
            <fbc:geneProductRef fbc:geneProduct="G_Rv2458"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv0511"/>
          </fbc:or>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_HDCAt2" reversible="false" name="Hexadecanoate transport via proton symport" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[e]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_hdca[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_hdca[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_HEX1" reversible="false" name="hexokinase (D-glucose:ATP)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_glc-D[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_g6p[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv0650"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_HISTD" reversible="false" name="histidinol dehydrogenase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_histd[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nad[c]" stoichiometry="2"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="3"/>
          <speciesReference constant="true" species="M_his-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadh[c]" stoichiometry="2"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv1599"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_HISTP" reversible="false" name="histidinol-phosphatase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_hisp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_histd[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_HISt2r" reversible="true" name="L-histidine reversible transport via proton symport" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[e]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_his-L[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_his-L[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_HMBS" reversible="false" name="hydroxymethylbilane synthase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ppbng[c]" stoichiometry="4"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_hmbil[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nh4[c]" stoichiometry="4"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv0510"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_HMPK1" reversible="false" name="hydroxymethylpyrimidine kinase (ATP)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_4ahmmp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_4ampm[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv0422c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_HMPK2" reversible="false" name="hydroxymethylpyrimidine kinase (CTP)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_4ahmmp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ctp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_4ampm[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_cdp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv0422c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_HMPK3" reversible="false" name="hydroxymethylpyrimidine kinase (UTP)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_4ahmmp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_utp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_4ampm[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_udp[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv0422c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_HMPK4" reversible="false" name="hydroxymethylpyrimidine kinase (GTP)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_4ahmmp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_gtp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_4ampm[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_gdp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv0422c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_HOPNTAL" reversible="false" name=" 4-hydroxy-2-oxopentanoate aldolase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_4h2opntn[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_acald[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pyr[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:or>
            <fbc:geneProductRef fbc:geneProduct="G_Rv3469c"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv3534c"/>
          </fbc:or>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_HPPK" reversible="false" name=" 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_2ahhmp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_2ahhmd[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_amp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv3606c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_HPPK2" reversible="false" name=" 6-hydroxymethyl-dihydropterin pyrophosphokinase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_6hmhpt[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_6hmhptpp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_amp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_HSDx" reversible="true" name="homoserine dehydrogenase (NADH)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_hom-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nad[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_aspsa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadh[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv1294"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_HSDy" reversible="true" name="homoserine dehydrogenase (NADPH)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_hom-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_aspsa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadph[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv1294"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_HSERTA" reversible="true" name="homoserine O-trans-acetylase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_accoa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_hom-L[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_achms[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_coa[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv3341"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_HSK" reversible="false" name="homoserine kinase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_hom-L[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_phom[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv1296"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_HSST" reversible="false" name="homoserine O-succinyltransferase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_hom-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_succoa[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_coa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_suchms[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_HSTPT" reversible="false" name="histidinol-phosphate transaminase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_glu-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_imacp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_akg[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_hisp[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:or>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1600"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv3772"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv2231c"/>
          </fbc:or>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_HXPRT" reversible="false" name="hypoxanthine phosphoribosyltransferase (Hypoxanthine)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_hxan[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_prpp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_imp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv3624c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_IACGAMS" reversible="false" name=" 1D-myo-inositol 2-Acetamido-2-deoxy-D-glucopyranoside synthesis" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_acgam[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_mi1p-D[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_iacgam[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv0486"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_ICDHy" reversible="false" name="isocitrate dehydrogenase (NADP)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_icit[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_akg[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadph[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:or>
            <fbc:geneProductRef fbc:geneProduct="G_Rv3339c"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv0066c"/>
          </fbc:or>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_ICHORSi" reversible="false" name="Isochorismate Synthase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_chor[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ichor[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv3215"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_ICL" reversible="false" name="Isocitrate lyase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_icit[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_glx[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_succ[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:or>
            <fbc:and>
              <fbc:geneProductRef fbc:geneProduct="G_Rv1916"/>
              <fbc:geneProductRef fbc:geneProduct="G_Rv1915"/>
            </fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_Rv0467"/>
          </fbc:or>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_ID3ACALDt" reversible="true" name="Indoleacetaldehyde transport (extracellular)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_id3acald[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_id3acald[e]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_IG3PS" reversible="false" name="Imidazole-glycerol-3-phosphate synthase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_gln-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_prlp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_aicar[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_eig3p[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_glu-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv1605"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_IGAMD" reversible="false" name=" 1D-myo-inositol 2-Acetamido-2-deoxy-D-glucopyranoside deacetylase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_iacgam[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ac[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_igam[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv1170"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_IGPDH" reversible="false" name="imidazoleglycerol-phosphate dehydratase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_eig3p[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_imacp[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv1601"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_IGPS" reversible="false" name="indole-3-glycerol-phosphate synthase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_2cpr5p[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_3ig3p[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv1611"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_ILETA" reversible="true" name="isoleucine transaminase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_akg[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ile-L[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_3mop[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_glu-L[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2210c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_ILEt2r" reversible="true" name="L-isoleucine reversible transport via proton symport" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[e]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ile-L[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ile-L[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_IMPC" reversible="true" name="IMP cyclohydrolase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_imp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_fprica[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv0957"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_IMPD" reversible="false" name="IMP dehydrogenase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_imp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nad[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadh[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_xmp[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_Rv3410c"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1843c"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv3411c"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_INDPYRD" reversible="true" name="Indole-3-pyruvate decarboxylase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_indpyr[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_id3acald[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv0853c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_INSH" reversible="false" name="Inosine hydrolase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ins[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_hxan[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_rib-D[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv3393"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_INSK" reversible="false" name="insosine kinase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ins[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_imp[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_IPDDI" reversible="true" name="isopentenyl-diphosphate D-isomerase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_ipdp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_dmpp[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv1745c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_IPDPS" reversible="false" name=" 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase (ipdp)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h2mb4p[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadh[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ipdp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nad[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_IPMD" reversible="false" name=" 3-isopropylmalate dehydrogenase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_3c2hmp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nad[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_3c4mop[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadh[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2995c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_IPPMIa" reversible="true" name=" 3-isopropylmalate dehydratase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_3c2hmp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_2ippm[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_Rv2987c"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv2988c"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_IPPMIb" reversible="true" name=" 2-isopropylmalate hydratase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_2ippm[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_3c3hmp[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_Rv2987c"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv2988c"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_IPPS" reversible="false" name=" 2-isopropylmalate synthase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_3mob[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_accoa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_3c3hmp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_coa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv3710"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_KARA1i" reversible="false" name="acetohydroxy acid isomeroreductase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_alac-S[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadph[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_23dhmb[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadp[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv3001c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_KARA2i" reversible="false" name="ketol-acid reductoisomerase (2-Aceto-2-hydroxybutanoate)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_2ahbut[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadph[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_23dhmp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadp[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv3001c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_Kabc" reversible="false" name="Potassium ABC transporter" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_k[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_k[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1030"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1031"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1029"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_Kt3r" reversible="true" name="potassium proton antiporter" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[e]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_k[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_k[e]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv3236c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_LACZ" reversible="false" name="b-galactosidase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_lcts[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_gal[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_glc-D[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_LCTSabc" reversible="false" name="lactose transport via ABC system (import)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_lcts[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_lcts[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_Rv2317"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv2318"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv2316"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_LDH_L" reversible="true" name="L-lactate dehydrogenase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_lac-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nad[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadh[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pyr[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv0694"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_LEUTA" reversible="true" name="leucine transaminase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_akg[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_leu-L[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_4mop[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_glu-L[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2210c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_LEUt2r" reversible="true" name="L-leucine reversible transport via proton symport" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[e]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_leu-L[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_leu-L[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_LO" reversible="false" name="L-lactate oxidase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_lac-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_o2[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ac[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_LPLIPAL2E160" reversible="false" name="Lysophospholipase L2 (2-acylglycerophosphoethanolamine, n-C16:0)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_2agpe160[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_g3pe[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_hdca[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv0183"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_LPLIPAL2E180" reversible="false" name="Lysophospholipase L2 (2-acylglycerophosphoethanolamine, n-C18:0)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_2agpe180[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_g3pe[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ocdca[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv0183"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_LYSt5r" reversible="true" name="L-lysine transport via diffusion" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_lys-L[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_lys-L[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2320c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_L_LACD" reversible="false" name="L-Lactate dehydrogenase irreversible" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_ficytc[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_lac-L[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_focytc[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_pyr[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv0694"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_L_LACD2" reversible="false" name="L-Lactate dehydrogenase (ubiquinone)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_lac-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_q8[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_pyr[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_q8h2[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv1872c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_L_LACD3" reversible="false" name="L-Lactate dehydrogenase (menaquinone)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_lac-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_mqn8[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_mql8[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pyr[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv1872c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_L_LACt2r" reversible="true" name="L-lactate reversible transport via proton symport" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[e]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_lac-L[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_lac-L[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv1902c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_L_LACt3" reversible="false" name="L-lactate transport out via proton antiport" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[e]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_lac-L[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_lac-L[e]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv0191"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_MALS" reversible="false" name="malate synthase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_accoa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_glx[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_coa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_mal-L[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv1837c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_MALT" reversible="false" name="alpha-glucosidase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_malt[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_glc-D[c]" stoichiometry="2"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2471"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_MALTHPabc" reversible="false" name="maltoheptaose transport via ABC system" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_malthp[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_malthp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1237"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1236"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1238"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_MALTabc" reversible="false" name="maltose transport via ABC system" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_malt[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_malt[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1237"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1236"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1238"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_MALt2r" reversible="true" name="L-malate reversible transport via proton symport" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[e]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_mal-L[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_mal-L[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2443"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_MAN1PT" reversible="false" name="mannose-1-phosphate guanylyltransferase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_gtp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_man1p[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_gdpmann[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv3264c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_MAN1PT2" reversible="false" name="mannose-1-phosphate guanylyltransferase (GDP)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_gdp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_man1p[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_gdpmann[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv3264c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_MAN6PI" reversible="true" name="mannose-6-phosphate isomerase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_man6p[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_f6p[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv3255c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_MANAT1" reversible="false" name="mannosyl acyl transferase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_PIM1[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pmtcoa[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_Ac1PIM1[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_coa[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2611c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_MANAT2" reversible="false" name="mannosyl acyl transferase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_PIM2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pmtcoa[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_Ac1PIM2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_coa[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2611c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_MANAT3" reversible="false" name="mannosyl acyl transferase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_Ac1PIM2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pmtcoa[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_Ac2PIM2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_coa[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_MCBTS" reversible="false" name="mycobactin synthesis" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_bhb[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_lys-L[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_o2[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_odecoa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_salc[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_thr-L[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_coa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="5"/>
          <speciesReference constant="true" species="M_mcbts[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_Rv2384"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv2379c"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv2380c"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv2383c"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv2382c"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv2378c"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv2381c"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_MCBTS2" reversible="false" name="mycobactin synthesis" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_bhb[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_lys-L[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_o2[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_odecoa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_salc[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ser-L[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_coa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="5"/>
          <speciesReference constant="true" species="M_mcbtt[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_Rv2384"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv2379c"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv2380c"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv2383c"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv2382c"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv2378c"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv2381c"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_MCBTS3" reversible="false" name="carboxymycobactin synthesis" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_bhb[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_lys-L[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_nadp[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_o2[c]" stoichiometry="3.5"/>
          <speciesReference constant="true" species="M_occoa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_salc[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ser-L[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_cmcbtt[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_coa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="5"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_nadph[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_Rv2384"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv2379c"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv2380c"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv2383c"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv2382c"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv2378c"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv2381c"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_MCD" reversible="false" name="Malonyl-CoA Decarboxylase cytoplasmic" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_malcoa[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_accoa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv1347c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_MCOATA" reversible="true" name="Malonyl-CoA-ACP transacylase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_ACP[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_malcoa[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_coa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_malACP[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:or>
            <fbc:geneProductRef fbc:geneProduct="G_Rv2243"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv0649"/>
          </fbc:or>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_MDFDH" reversible="true" name="mycothiol dependent formaldehyde dehydrogenase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_mshfald[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nad[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_mshfaldox[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadh[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv1895"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_MDH" reversible="true" name="malate dehydrogenase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_mal-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nad[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadh[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_oaa[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv1240"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_ME1" reversible="false" name="malic enzyme (NAD)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_mal-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nad[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadh[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pyr[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2332"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_MECDPDH" reversible="false" name=" 2C-methyl-D-erythritol 2,4 cyclodiphosphate dehydratase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_2mecdp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h2mb4p[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_MECDPS" reversible="false" name=" 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_2p4c2me[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_2mecdp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_cmp[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv3581c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_MEOHt2" reversible="true" name="Methanol diffusion" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_meoh[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_meoh[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_MEPCT" reversible="false" name=" 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_2me4p[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ctp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_4c2me[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv3582c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_METAT" reversible="false" name="methionine adenosyltransferase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_met-L[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_amet[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv1392"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_METOX1s" reversible="false" name="methionine oxidation (spontaneous)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h2o2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_met-L[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_metsox-S-L[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_METOX2s" reversible="false" name="methionine oxidation 2 (spontaneous)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h2o2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_met-L[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_metsox-R-L[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_METS" reversible="false" name="methionine synthase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_5mthf[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_hcys-L[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_met-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_thf[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2124c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_METSOXR1" reversible="false" name="L-methionine-S-oxide reductase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_metsox-S-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_trdrd[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_met-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_trdox[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv0137c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_METSOXR2" reversible="false" name="L-methionine-R-sulfoxide reductase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_metsox-R-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_trdrd[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_met-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_trdox[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2674"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_METabc" reversible="false" name="L-methionine transport via ABC system" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_met-L[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_met-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_MGt5" reversible="true" name="magnesium transport in/out via permease (no H+)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_mg2[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_mg2[e]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv1239c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_MHPGLUT" reversible="false" name=" 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_hcys-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_mhpglu[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_hpglu[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_met-L[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv1133c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_MI1PP" reversible="false" name="myo-inositol 1-phosphatase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_mi1p-D[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_inost[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:or>
            <fbc:geneProductRef fbc:geneProduct="G_Rv2701c"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1604"/>
          </fbc:or>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_MI1PS" reversible="false" name="myo-Inositol-1-phosphate synthase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_g6p[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_mi1p-D[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv0046c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_MI3PP" reversible="false" name="myo-inositol 3-phosphatase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_mi3p-D[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_inost[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv1604"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_MI4PP" reversible="false" name="myo-inositol 4-phosphatase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_mi4p-D[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_inost[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv1604"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_MMCD" reversible="false" name="Methylmalonyl-CoA decarboxylase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_mmcoa-S[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ppcoa[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_MME" reversible="true" name="methylmalonyl-CoA epimerase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_mmcoa-R[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_mmcoa-S[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv0855"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_MMM2r" reversible="true" name="Methylmalonyl-CoA mutase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_succoa[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_mmcoa-R[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1493"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1492"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_MMSAD1" reversible="false" name="methylmalonate-semialdehyde dehydrogenase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_2mop[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_coa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nad[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadh[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ppcoa[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv0753c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_MMSAD2" reversible="false" name="methylmalonate-semialdehyde dehydrogenase (propanol)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_coa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nad[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ppal[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadh[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ppcoa[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv0753c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_MMSAD3" reversible="false" name="methylmalonate-semialdehyde dehydrogenase (malonic semialdehyde)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_coa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_msa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nad[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_accoa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadh[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv0753c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_MN6PP" reversible="false" name="mannose 6-phosphate phosphatase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_man6p[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_man[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv1692"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_MNDNS1" reversible="false" name="menadione synthase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_dhna[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="3"/>
          <speciesReference constant="true" species="M_nadph[c]" stoichiometry="2"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_mndn[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadp[c]" stoichiometry="2"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_MNDNS2" reversible="false" name="menadione synthase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_dhna[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="3"/>
          <speciesReference constant="true" species="M_nadh[c]" stoichiometry="2"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_mndn[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nad[c]" stoichiometry="2"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_MOHMT" reversible="false" name=" 3-methyl-2-oxobutanoate hydroxymethyltransferase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_3mob[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_mlthf[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_2dhp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_thf[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2225"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_MOTH" reversible="false" name="maltooligosyltrehalose trehalohydrolase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_motre[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_maltpt[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_tre[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv1562c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_MOTS" reversible="false" name="maltooligosyltrehalose synthase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_malthp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_motre[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv1563c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_MPML" reversible="true" name="Mg-protoporphyrin IX magnesium-lyase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_mg2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ppp9[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="3"/>
          <speciesReference constant="true" species="M_mppp9[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv0958"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_MSHAMID" reversible="false" name="conjugated glutathione amidase (Mtb)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_bmnmsh[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_acysbmn[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_igam[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv1082"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_MSHOXH" reversible="false" name="mshfaldox hydrolysis (Mtb)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_mshfaldox[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_for[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_msh[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_MSHS" reversible="false" name="mycothiol synthase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_accoa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_cigam[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_coa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_msh[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv0819"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_MTAN" reversible="false" name="methylthioadenosine nucleosidase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_5mta[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_5mtr[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ade[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv0091"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_MTHFC" reversible="true" name="methenyltetrahydrofolate cyclohydrolase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_methf[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_10fthf[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv3356c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_MTHFD" reversible="true" name="methylenetetrahydrofolate dehydrogenase (NADP)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_mlthf[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_methf[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadph[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv3356c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_MTHFD2" reversible="true" name="methylenetetrahydrofolate dehydrogenase (NAD)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_mlthf[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nad[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_methf[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadh[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv3356c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_MTHFR2" reversible="false" name=" 5,10-methylenetetrahydrofolate reductase (NADH)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_mlthf[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadh[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_5mthf[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nad[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_MTI" reversible="true" name="maltose trehalose isomerase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_tre[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_malt[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv0126"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_MYC1CYC1" reversible="false" name="Mycolic Acid Cyclopropanation" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_amet[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_meroacidACP[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ahcys[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_meroacidcyc1ACP[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv0470c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_MYC1CYC2" reversible="false" name="Mycolic Acid Cyclopropanation" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_amet[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_mmeroacidACP[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ahcys[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_mmeroacidcyc1ACP[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv0470c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_MYC1CYC3" reversible="false" name="Mycolic Acid Cyclopropanation" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_amet[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_kmeroacidACP[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ahcys[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_kmeroacidcyc1ACP[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv0470c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_MYC1CYC4" reversible="false" name="Mycolic Acid Cyclopropanation" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_amet[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_mmmeroacidACP[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ahcys[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_mmmeroacidcyc1ACP[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:or>
            <fbc:geneProductRef fbc:geneProduct="G_Rv0503c"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv0644c"/>
          </fbc:or>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_MYC1CYC5" reversible="false" name="Mycolic Acid Cyclopropanation" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_amet[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_mkmeroacidACP[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ahcys[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_mkmeroacidcyc1ACP[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:or>
            <fbc:geneProductRef fbc:geneProduct="G_Rv0644c"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv0503c"/>
          </fbc:or>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_MYC1M1" reversible="false" name="Mycolic Acid Methyl Hydroxyl Addition" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_amet[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_mmeroacidACP[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ahcys[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_mmmeroacidACP[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:or>
            <fbc:geneProductRef fbc:geneProduct="G_Rv0503c"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv0644c"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv0645c"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv0642c"/>
          </fbc:or>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_MYC1M2" reversible="false" name="Mycolic Acid Methyl Hydroxyl Addition" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_amet[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_kmeroacidACP[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ahcys[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_mkmeroacidACP[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:or>
            <fbc:geneProductRef fbc:geneProduct="G_Rv0645c"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv0644c"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv0503c"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv0642c"/>
          </fbc:or>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_MYC2CYC1" reversible="false" name="Mycolic Acid Cyclopropanation" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_amet[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_meroacidcyc1ACP[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ahcys[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_meroacidcyc2ACP[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv0644c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_MYC2CYC2" reversible="false" name="Mycolic Acid Cyclopropanation" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_amet[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_mmeroacidcyc1ACP[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ahcys[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_mmeroacidcyc2ACP[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv0644c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_MYC2CYC3" reversible="false" name="Mycolic Acid Cyclopropanation" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_amet[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_kmeroacidcyc1ACP[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ahcys[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_kmeroacidcyc2ACP[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv0644c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_MYCFLUX1" reversible="false" name="mycolic acid conglomeration flux" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_mycolate[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_rmyc[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_MYCFLUX2" reversible="false" name="mycolic acid conglomeration flux" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_mmycolate[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_rmyc[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_MYCFLUX3" reversible="false" name="mycolic acid conglomeration flux" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_kmycolate[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_rmyc[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_MYCFLUX4" reversible="false" name="mycolic acid conglomeration flux" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_mmmycolate[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_rmyc[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_MYCFLUX5" reversible="false" name="mycolic acid conglomeration flux" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_mkmycolate[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_rmyc[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_MYCON1" reversible="false" name="Mycolic Acid Condensation" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_chexccoa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_meroacidcyc2AMP[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_amp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_coa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_mycolate[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv3800c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_MYCON2" reversible="false" name="Mycolic Acid Condensation" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_chexccoa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_mmeroacidcyc2AMP[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_amp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_coa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_mmycolate[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv3800c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_MYCON3" reversible="false" name="Mycolic Acid Condensation" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_chexccoa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_kmeroacidcyc2AMP[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_amp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_coa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_kmycolate[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv3800c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_MYCON4" reversible="false" name="Mycolic Acid Condensation" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_chexccoa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_mmmeroacidcyc1AMP[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_amp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_coa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_mmmycolate[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv3800c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_MYCON5" reversible="false" name="Mycolic Acid Condensation" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_chexccoa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_mkmeroacidcyc1AMP[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_amp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_coa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_mkmycolate[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv3800c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_MYCSacp50" reversible="false" name="mycolic acid synthase (C50)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="33"/>
          <speciesReference constant="true" species="M_hexc[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_malACP[c]" stoichiometry="12"/>
          <speciesReference constant="true" species="M_nadph[c]" stoichiometry="24"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ACP[c]" stoichiometry="11"/>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="12"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="13"/>
          <speciesReference constant="true" species="M_meroacidACP[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadp[c]" stoichiometry="24"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:or>
            <fbc:and>
              <fbc:geneProductRef fbc:geneProduct="G_Rv2245"/>
              <fbc:geneProductRef fbc:geneProduct="G_Rv1483"/>
              <fbc:geneProductRef fbc:geneProduct="G_Rv2246"/>
            </fbc:and>
            <fbc:and>
              <fbc:geneProductRef fbc:geneProduct="G_Rv2245"/>
              <fbc:geneProductRef fbc:geneProduct="G_Rv2246"/>
              <fbc:geneProductRef fbc:geneProduct="G_Rv0098"/>
            </fbc:and>
          </fbc:or>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_MYCSacp56" reversible="false" name="mycolic acid synthase (C56)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="42"/>
          <speciesReference constant="true" species="M_hexc[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_malACP[c]" stoichiometry="15"/>
          <speciesReference constant="true" species="M_nadph[c]" stoichiometry="30"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ACP[c]" stoichiometry="14"/>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="15"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="16"/>
          <speciesReference constant="true" species="M_mmeroacidACP[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadp[c]" stoichiometry="30"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:or>
            <fbc:and>
              <fbc:geneProductRef fbc:geneProduct="G_Rv2245"/>
              <fbc:geneProductRef fbc:geneProduct="G_Rv1483"/>
              <fbc:geneProductRef fbc:geneProduct="G_Rv2246"/>
            </fbc:and>
            <fbc:and>
              <fbc:geneProductRef fbc:geneProduct="G_Rv2245"/>
              <fbc:geneProductRef fbc:geneProduct="G_Rv2246"/>
              <fbc:geneProductRef fbc:geneProduct="G_Rv0098"/>
            </fbc:and>
          </fbc:or>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_MYCSacp58" reversible="false" name="mycolic acid synthase (C58)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="47"/>
          <speciesReference constant="true" species="M_hexc[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_malACP[c]" stoichiometry="16"/>
          <speciesReference constant="true" species="M_nadph[c]" stoichiometry="30"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ACP[c]" stoichiometry="15"/>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="16"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="17"/>
          <speciesReference constant="true" species="M_kmeroacidACP[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadp[c]" stoichiometry="30"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:or>
            <fbc:and>
              <fbc:geneProductRef fbc:geneProduct="G_Rv2245"/>
              <fbc:geneProductRef fbc:geneProduct="G_Rv1483"/>
              <fbc:geneProductRef fbc:geneProduct="G_Rv2246"/>
            </fbc:and>
            <fbc:and>
              <fbc:geneProductRef fbc:geneProduct="G_Rv2245"/>
              <fbc:geneProductRef fbc:geneProduct="G_Rv2246"/>
              <fbc:geneProductRef fbc:geneProduct="G_Rv0098"/>
            </fbc:and>
          </fbc:or>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_MYCTR" reversible="true" name="mycothiol reductase (nadp dependent)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_msh[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_nadp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_mssg[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadph[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2855"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_MYCTR2" reversible="true" name="mycothiol reductase (glutathione exchange)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_gthox[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_msh[c]" stoichiometry="2"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_gthrd[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_mssg[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2855"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_NADH10" reversible="false" name="NADH dehydrogenase (menaquinone-8 &amp; 0 protons)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_mqn8[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadh[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_mql8[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nad[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_Rv3158"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv3149"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv3145"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv3156"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv3154"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv3152"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv3153"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv3150"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv0082"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv3148"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv3146"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv3157"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv3147"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv3155"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_NADH2r" reversible="true" name="NADH dehydrogenase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadh[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_q[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_nad[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_qh2[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_Rv3158"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv3149"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv3145"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv3156"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv3154"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv3152"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv3153"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv3150"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv0082"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv3148"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv3146"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv3157"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv3147"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv3155"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_NADH5" reversible="false" name="NADH dehydrogenase (ubiquinone-8 )" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadh[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_q8[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_nad[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_q8h2[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_Rv3158"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv3149"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv3145"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv3156"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv3154"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv3152"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv3153"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv3150"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv0082"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv3148"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv3146"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv3157"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv3147"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv3155"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_NADH9" reversible="false" name="NADH dehydrogenase (demethylmenaquinone-8 &amp; 0 protons)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_2dmmq8[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadh[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_2dmmql8[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nad[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_Rv3158"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv3149"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv3145"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv3156"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv3154"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv3152"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv3153"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv3150"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv0082"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv3148"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv3146"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv3157"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv3147"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv3155"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_NADK" reversible="false" name="NAD kinase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nad[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadp[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv1695"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_NADS2" reversible="false" name="NAD synthase (glutamine-hydrolysing)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_dnad[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_gln-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_amp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_glu-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nad[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2438c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_NADTRHD" reversible="false" name="NAD transhydrogenase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_nad[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadph[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_nadh[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadp[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_Rv0157"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv0156"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv0155"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_NAKtr" reversible="true" name="potassium sodium antiporter" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_k[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_na1[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_k[e]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_na1[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv3236c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_NAPRTr" reversible="true" name="NAPRTase (rev)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nac[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_prpp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_nicrnt[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv0573c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_NARK" reversible="false" name="nark" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_no2[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_no2[e]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:or>
            <fbc:geneProductRef fbc:geneProduct="G_Rv0261c"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv0267"/>
            <fbc:and>
              <fbc:geneProductRef fbc:geneProduct="G_Rv2329c"/>
              <fbc:geneProductRef fbc:geneProduct="G_Rv1737c"/>
            </fbc:and>
          </fbc:or>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_NAt3_1" reversible="true" name="sodium proton antiporter (H:NA is 1:1)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[e]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_na1[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_na1[e]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2287"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_NDPK1" reversible="true" name="nucleoside-diphosphate kinase (ATP:GDP)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_gdp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_gtp[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2445c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_NDPK2" reversible="true" name="nucleoside-diphosphate kinase (ATP:UDP)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_udp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_utp[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2445c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_NDPK3" reversible="true" name="nucleoside-diphosphate kinase (ATP:CDP)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_cdp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ctp[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2445c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_NDPK4" reversible="true" name="nucleoside-diphosphate kinase (ATP:dTDP)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_dtdp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_dttp[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2445c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_NDPK5" reversible="true" name="nucleoside-diphosphate kinase (ATP:dGDP)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_dgdp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_dgtp[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2445c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_NDPK6" reversible="true" name="nucleoside-diphosphate kinase (ATP:dUDP)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_dudp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_dutp[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2445c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_NDPK7" reversible="true" name="nucleoside-diphosphate kinase (ATP:dCDP)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_dcdp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_dctp[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2445c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_NDPK8" reversible="true" name="nucleoside-diphosphate kinase (ATP:dADP)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_dadp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_datp[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2445c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_NDPK9" reversible="true" name="nucleoside-diphosphate kinase (ATP:IDP)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_idp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_itp[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2445c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_NH4OHDs" reversible="true" name="NH4OH dissociation" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nh4oh[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nh4[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_NH4t" reversible="true" name="ammonia reversible transport" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_nh4[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_nh4[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2920c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_NNAM" reversible="false" name="nicotinamidase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ncam[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_nac[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nh4[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2043c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_NNAT" reversible="false" name="nicotinate-nucleotide adenylyltransferase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nicrnt[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_dnad[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2421c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_NNDMBRT" reversible="false" name="Nicotinate-nucleotide dimethylbenzimidazole phosphoribosyltransferase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_dmbzid[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nicrnt[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_5prdmbz[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nac[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2207"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_NNDPR" reversible="false" name="nicotinate-nucleotide diphosphorylase (carboxylating)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_prpp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_quln[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nicrnt[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv1596"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_NO" reversible="false" name="peroxynitrite formation (spontanous)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_no[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_o2s[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_no3[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_NO3R1" reversible="false" name="Nitrate reductase (Ubiquinol-8)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_no3[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_q8h2[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[e]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_no2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_q8[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1162"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1161"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1164"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1163"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_NO3R2" reversible="false" name="Nitrate reductase (Menaquinol-8)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_mql8[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_no3[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[e]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_mqn8[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_no2[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1162"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1161"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1164"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1163"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_NO3t7" reversible="false" name="nitrate transport in via nitrite antiport" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_no2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_no3[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_no2[e]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_no3[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:or>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1737c"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1737c"/>
          </fbc:or>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_NOt" reversible="true" name="NO transport (diffusion)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_no[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_no[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_NPHS" reversible="false" name="naphthoate synthase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_sbzcoa[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_coa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_dhna[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv0548c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_NTD1" reversible="false" name=" 5&apos;-nucleotidase (dUMP)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_dump[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_duri[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_NTD10" reversible="false" name=" 5&apos;-nucleotidase (XMP)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_xmp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_xtsn[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_NTD11" reversible="false" name=" 5&apos;-nucleotidase (IMP)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_imp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ins[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_NTD2" reversible="false" name=" 5&apos;-nucleotidase (UMP)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ump[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_uri[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_NTD3" reversible="false" name=" 5&apos;-nucleotidase (dCMP)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_dcmp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_dcyt[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_NTD4" reversible="false" name=" 5&apos;-nucleotidase (CMP)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_cmp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_cytd[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_NTD5" reversible="false" name=" 5&apos;-nucleotidase (dTMP)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_dtmp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_thymd[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_NTD6" reversible="false" name=" 5&apos;-nucleotidase (dAMP)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_damp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_dad-2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_NTD7" reversible="false" name=" 5&apos;-nucleotidase (AMP)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_amp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adn[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_NTD8" reversible="false" name=" 5&apos;-nucleotidase (dGMP)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_dgmp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_dgsn[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_NTD9" reversible="false" name=" 5&apos;-nucleotidase (GMP)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_gmp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_gsn[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_NTPP2" reversible="false" name="Nucleoside triphosphate pyrophosphorylase (gtp)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_gtp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_gmp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_NTPP3" reversible="false" name="Nucleoside triphosphate pyrophosphorylase (dctp)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_dctp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_dcmp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_NTPP4" reversible="false" name="Nucleoside triphosphate pyrophosphorylase (ctp)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_ctp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_cmp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_NTPP5" reversible="false" name="Nucleoside triphosphate pyrophosphorylase (datp)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_datp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_damp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_NTPP7" reversible="false" name="Nucleoside triphosphate pyrophosphorylase (dttp)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_dttp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_dtmp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_NTPP8" reversible="false" name="Nucleoside triphosphate pyrophosphorylase (utp)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_utp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ump[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_NTPTP1" reversible="false" name="Nucleoside triphosphate tripolyhydrolase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_dgtp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_dgsn[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pppi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2344c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_NTPTP2" reversible="false" name="Nucleoside triphosphate tripolyhydrolase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_gtp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_gsn[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pppi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2344c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_NTRIR2x" reversible="false" name="nitrite Reductase (NADH)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="5"/>
          <speciesReference constant="true" species="M_nadh[c]" stoichiometry="3"/>
          <speciesReference constant="true" species="M_no2[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_nad[c]" stoichiometry="3"/>
          <speciesReference constant="true" species="M_nh4[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_Rv0252"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv0253"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv2391"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_NTRIRx" reversible="false" name="nitrite reductase (NADH)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="4"/>
          <speciesReference constant="true" species="M_nadh[c]" stoichiometry="3"/>
          <speciesReference constant="true" species="M_no2[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nad[c]" stoichiometry="3"/>
          <speciesReference constant="true" species="M_nh4oh[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_Rv0252"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv0253"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv2391"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_NTRIRy" reversible="false" name="nitrite reductase (NADPH)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="4"/>
          <speciesReference constant="true" species="M_nadph[c]" stoichiometry="3"/>
          <speciesReference constant="true" species="M_no2[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadp[c]" stoichiometry="3"/>
          <speciesReference constant="true" species="M_nh4oh[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_Rv0252"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv0253"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv2391"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_O16RHAT" reversible="false" name="rhamnosyltransferase (LPS O16 antigen biosynthesis)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_dtdprmn[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_unaga[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_dtdp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ragund[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv3265c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_O2t" reversible="true" name="o2 transport (diffusion)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_o2[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_o2[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_OCBT" reversible="true" name="ornithine carbamoyltransferase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_cbp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_orn[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_citr-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv1656"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_OCDCAt2" reversible="false" name="Octadecanoate transport via proton symport" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[e]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ocdca[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ocdca[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_OCOAT1r" reversible="true" name=" 3-oxoacid CoA-transferase (Succinyl-CoA: acetoacetate)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_acac[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_succoa[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_aacoa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_succ[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_Rv2503c"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv2504c"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_OCTDPS" reversible="false" name="Octaprenyl pyrophosphate synthase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_frdp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ipdp[c]" stoichiometry="5"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_octdp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="5"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_OHPBAT" reversible="true" name="O-Phospho-4-hydroxy-L-threonine:2-oxoglutarate aminotransferase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_glu-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ohpb[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_akg[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_phthr[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv0884c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_OMCDC" reversible="false" name=" 2-Oxo-4-methyl-3-carboxypentanoate decarboxylation" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_3c4mop[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_4mop[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_OMPDC" reversible="false" name="orotidine-5&apos;-phosphate decarboxylase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_orot5p[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ump[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv1385"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_OPAH" reversible="true" name=" 5-Oxoproline amidohydrolase (ATP-hydrolysing)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_5oxpro[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="2"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_glu-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv0266c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_ORNTA" reversible="false" name="ornithine transaminase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_akg[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_orn[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_glu-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_glu5sa[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_Rv2322c"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv2321c"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_ORNTAC" reversible="true" name="ornithine transacetylase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_acorn[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_glu-L[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_acglu[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_orn[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv1653"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_ORNt" reversible="true" name="ornithine transport via diffusion (extracellular to periplasm)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_orn[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_orn[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2320c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_ORPT" reversible="true" name="orotate phosphoribosyltransferase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_orot5p[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_orot[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_prpp[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv0382c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_OXACOAL" reversible="true" name="oxalate-coa ligase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_coa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_oxa[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_amp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_oxalcoa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_OXCDC" reversible="false" name="Oxalyl-CoA decarboxylase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_oxalcoa[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_forcoa[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv0118c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_OXGDC" reversible="false" name=" 2-oxoglutarate decarboxylase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_akg[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_sucsal[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv1248c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_OXGDC2" reversible="false" name=" 2-oxoglutarate decarboxylase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_akg[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_thmpp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ssaltpp[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv0555"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_P5CD" reversible="false" name=" 1-pyrroline-5-carboxylate dehydrogenase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_1pyr5c[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_nad[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_glu-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadh[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:or>
            <fbc:or>
              <fbc:geneProductRef fbc:geneProduct="G_Rv1187"/>
              <fbc:geneProductRef fbc:geneProduct="G_Rv1187"/>
            </fbc:or>
            <fbc:or>
              <fbc:geneProductRef fbc:geneProduct="G_Rv1187"/>
              <fbc:geneProductRef fbc:geneProduct="G_Rv1187"/>
            </fbc:or>
          </fbc:or>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_P5CR" reversible="false" name="pyrroline-5-carboxylate reductase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_1pyr5c[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_nadph[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_nadp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pro-L[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv0500"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_P5CRx" reversible="false" name="pyrroline-5-carboxylate reductase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_1pyr5c[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_nadh[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_nad[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pro-L[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv0500"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PACt2r" reversible="true" name="phenylacetate transport in via proton symporter" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[e]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pac[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pac[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_PANTS" reversible="false" name="pantothenate synthase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_ala-B[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pant-R[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_amp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pnto-R[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv3602c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PAPA160" reversible="false" name="Phosphatidate phosphatase (n-C16:0)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pa160[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_12dgr160[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv1755c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PAPPT1" reversible="false" name="phospho-N-acetylmuramoyl-pentapeptide-transferase (alpha-glutamate)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_uAgla[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_udcpp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_uaAgla[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ump[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2156c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PAPPT2" reversible="false" name="phospho-N-acetylmuramoyl-pentapeptide-transferase (gamma-glutamate)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_uGgla[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_udcpp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_uaGgla[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ump[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2156c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PAPPT3" reversible="false" name="phospho-N-acetylmuramoyl-pentapeptide-transferase (meso-2,6-diaminopimelate)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_udcpp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ugmda[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_uagmda[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ump[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2156c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PAPR" reversible="true" name="Phosphoadenosine phosphosulfate reductase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_paps[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_trdrd[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_pap[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_so3[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_trdox[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2392"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PATS" reversible="false" name="penta-acyl trehalose synthesis" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="5"/>
          <speciesReference constant="true" species="M_ocdca[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_tmlgnc[c]" stoichiometry="4"/>
          <speciesReference constant="true" species="M_tre[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="5"/>
          <speciesReference constant="true" species="M_pat[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_PC" reversible="false" name="pyruvate carboxylase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_hco3[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pyr[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_oaa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:or>
            <fbc:geneProductRef fbc:geneProduct="G_Rv2697c"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv2967c"/>
          </fbc:or>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PC11M" reversible="false" name="precorrin-4 C11-methyltransferase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_amet[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pre4[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ahcys[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pre5[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2071c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PC17M" reversible="false" name="precorrin-3B C17-methyltransferase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_amet[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pre3b[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ahcys[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="3"/>
          <speciesReference constant="true" species="M_pre4[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2066"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PC20M" reversible="false" name="precorrin-2 C20-methyltransferase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_amet[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_dscl[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ahcys[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pre3a[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2066"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PC6AR" reversible="false" name="precorrin-6A reductase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadph[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pre6a[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_nadp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pre6b[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2070c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PC6YM" reversible="false" name="precorrin-6Y C5,15-methyltransferase (decarboxylating)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_amet[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_pre6b[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ahcys[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_pre8[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2072c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PC8XM" reversible="false" name="precorrin-8X methylmutase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pre8[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_hgbyr[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2065"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PDE1" reversible="false" name=" 3&apos;,5&apos;-cyclic-nucleotide phosphodiesterase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_camp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_amp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv0805"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PDE4" reversible="false" name=" 3&apos;,5&apos;-cyclic-nucleotide phosphodiesterase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_35cgmp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_gmp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv0805"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PDH" reversible="false" name="pyruvate dehydrogenase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_coa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nad[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pyr[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_accoa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadh[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_Rv2241"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv2215"/>
            <fbc:or>
              <fbc:geneProductRef fbc:geneProduct="G_Rv0462"/>
              <fbc:geneProductRef fbc:geneProduct="G_Rv0843"/>
            </fbc:or>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PDHa" reversible="false" name="pyruvate dehydrogenase (lipoamide)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_lpam[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pyr[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adhlam[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:or>
            <fbc:or>
              <fbc:geneProductRef fbc:geneProduct="G_Rv0462"/>
              <fbc:geneProductRef fbc:geneProduct="G_Rv0843"/>
            </fbc:or>
            <fbc:and>
              <fbc:geneProductRef fbc:geneProduct="G_Rv2496c"/>
              <fbc:geneProductRef fbc:geneProduct="G_Rv2497c"/>
            </fbc:and>
          </fbc:or>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PDHbr" reversible="true" name="pyruvate dehydrogenase (dihydrolipoamide) reversible" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_adhlam[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_coa[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_accoa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_dhlam[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2495c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PDHc" reversible="false" name="pyruvate dehydrogenase (dihydrolipoamide dehydrogenase)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_dhlam[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nad[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_lpam[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadh[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:or>
            <fbc:geneProductRef fbc:geneProduct="G_Rv0462"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv0843"/>
          </fbc:or>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PDHcr" reversible="true" name="Pyruvate dehydrogenase (dihydrolipoamide dehydrogenase) reversible" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_dhlam[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nad[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_lpam[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadh[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_Rv3303c"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv0794c"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PDIMAS" reversible="false" name="PDIM A synthesis (Mycobacterium Tuberculosis)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_phthiocerol[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_tamocta[c]" stoichiometry="2"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_pdima[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2941"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PDIMAT" reversible="false" name="pdima translocase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_pdima[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_pdima[e]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2945c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PDX5PO" reversible="true" name="pyridoxine 5&apos;-phosphate oxidase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_o2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pdx5p[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h2o2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pydx5p[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2607"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PEAMNO" reversible="false" name="Phenethylamine oxidase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_o2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_peamn[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h2o2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nh4[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pacald[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_PEPCK_re" reversible="true" name="phosphoenolpyruvate carboxykinase (GTP)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_gtp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_oaa[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_gdp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pep[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv0211"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PERD" reversible="true" name="Erythronate 4-phosphate (4per) dehydrogenase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_4per[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nad[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadh[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ohpb[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_PFK" reversible="false" name="phosphofructokinase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_f6p[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_fdp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_Rv2029c"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv3010c"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PFL" reversible="false" name="pyruvate formate lyase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_coa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pyr[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_accoa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_for[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_PGAMT" reversible="true" name="phosphoglucosamine mutase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_gam1p[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_gam6p[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_PGCD" reversible="false" name="phosphoglycerate dehydrogenase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_3pg[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nad[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_3php[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadh[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:or>
            <fbc:geneProductRef fbc:geneProduct="G_Rv0728c"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv2996c"/>
          </fbc:or>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PGI" reversible="true" name="glucose-6-phosphate isomerase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_g6p[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_f6p[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv0946c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PGK" reversible="true" name="phosphoglycerate kinase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_3pg[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_13dpg[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv1437"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PGL" reversible="false" name=" 6-phosphogluconolactonase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_6pgl[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_6pgc[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv1445c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PGLS" reversible="false" name="methoxy fucose rhamnose rhamnose phenol phthiocerol dimycocerosate synthesis" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_amet[c]" stoichiometry="4"/>
          <speciesReference constant="true" species="M_frrppdima[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ahcys[c]" stoichiometry="4"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="4"/>
          <speciesReference constant="true" species="M_mfrrppdima[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_PGLYCP" reversible="false" name="Phosphoglycolate phosphatase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_2pglyc[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_glyclt[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2233"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PGM" reversible="true" name="phosphoglycerate mutase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_2pg[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_3pg[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv0489"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PGMT" reversible="true" name="phosphoglucomutase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_g1p[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_g6p[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv3068c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PGPP160" reversible="false" name="phosphatidylglycerol phosphate phosphatase (n-C16:0)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pgp160[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_pg160[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_PGPP160190" reversible="false" name="phosphatidylglycerol phosphate phosphatase (C16:0, C19:0)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pgp160190[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_pg160190[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_PGPP190" reversible="false" name="phosphatidylglycerol phosphate phosphatase (C19:0)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pgp190[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_pg190[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_PGPPT3" reversible="false" name="phospho-N-glycolylmuramoyl-pentapeptide-transferase (meso-2,6-diaminopimelate)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_udcpp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_uggmda[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ugggmda[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ump[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2156c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PGSA160" reversible="false" name="Phosphatidylglycerol synthase (n-C16:0)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_cdpdhdecg[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_glyc3p[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_cmp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pgp160[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:or>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1822"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv2746c"/>
          </fbc:or>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PGSA160190" reversible="false" name="Phosphatidylglycerol synthase (C16:0,C19:0)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_cdpc16c19g[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_glyc3p[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_cmp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pgp160190[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:or>
            <fbc:geneProductRef fbc:geneProduct="G_Rv2746c"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1822"/>
          </fbc:or>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PGSA190" reversible="false" name="Phosphatidylglycerol synthase (C19:0)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_cdpc19c19g[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_glyc3p[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_cmp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pgp190[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:or>
            <fbc:geneProductRef fbc:geneProduct="G_Rv2746c"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1822"/>
          </fbc:or>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PHDCATA" reversible="true" name="transacylase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_ACP[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_phdcacoa[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_coa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_phdcaACP[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_PHDCAt" reversible="true" name="phenol palmitic acid via diffusion (extracellular)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_phdca[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_phdca[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_PHETA1" reversible="true" name="phenylalanine transaminase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_akg[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_phe-L[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_glu-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_phpyr[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_PHEt2r" reversible="true" name="L-phenylalanine reversible transport via proton symport" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[e]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_phe-L[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_phe-L[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_PHTHCLR1" reversible="true" name="phthiocol reductase (NAD)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_nad[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_phthclh2[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadh[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_phthcl[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_PHTHCLR2" reversible="true" name="phthiocol reductase (NAD)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_nadp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_phthclh2[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadph[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_phthcl[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_PHTHCLS" reversible="false" name="phthiocol synthesis" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_mndn[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadph[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_o2[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_phthcl[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_PHTHDLS" reversible="false" name="phthiodolone synthesis" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_prephth[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_phthdl[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_PHTHDLS2" reversible="false" name="phenolphthiodolone synthesis" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_prepphth[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pphthdl[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_PHTHS" reversible="false" name="phthiocerol synthesis" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_amet[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadph[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_phthdl[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ahcys[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_phthiocerol[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_PHTHS2" reversible="false" name="phenolphthiocerol synthesis" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_amet[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadph[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pphthdl[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ahcys[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pphthiocerol[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_PHTO" reversible="false" name="phthiocol oxygenase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_o2[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_phthclh2[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_o2s[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_phthcl[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_PHYCBOXL" reversible="false" name="L-Phenylalanine carboxy-lyase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_phe-L[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_peamn[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2531c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PIabc" reversible="false" name="phosphate transport via ABC system" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="2"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:or>
            <fbc:geneProductRef fbc:geneProduct="G_Rv0936"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv0820"/>
          </fbc:or>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PIt" reversible="true" name="Inorganic phosphate exchange, diffusion" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_pi[e]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_Rv0545c"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv2281"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PLCD" reversible="false" name="phospholipase C" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ptd1ino160[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_12dgr160[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_mi1p-D[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv1755c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PLIPA1E160" reversible="false" name="Phospholipase A1 (phosphatidylethanolamine, n-C16:0)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pe160[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_2agpe160[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_hdca[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_PLIPA1E180" reversible="false" name="Phospholipase A1 (phosphatidylethanolamine, n-C18:0)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pe180[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_2agpe180[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ocdca[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_PMANM" reversible="true" name="phosphomannomutase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_man1p[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_man6p[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:or>
            <fbc:geneProductRef fbc:geneProduct="G_Rv3257c"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv3308"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv3441c"/>
          </fbc:or>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PMDPHT" reversible="false" name="pyrimidine phosphatase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_5aprbu[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_4r5au[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_PMPK" reversible="false" name="phosphomethylpyrimidine kinase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_4ampm[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_2mahmp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv0422c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PNCDC" reversible="false" name="pantothenoylcysteine decarboxylase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ptcys[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ptth[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv1092c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PNTK" reversible="false" name="pantothenate kinase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pnto-R[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_4ppan[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv1092c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PPA" reversible="false" name="inorganic diphosphatase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="2"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv3628"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PPAtr" reversible="true" name="Propionate transport, diffusion" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_ppa[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ppa[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_PPBNGS" reversible="false" name="porphobilinogen synthase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_5aop[c]" stoichiometry="2"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ppbng[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv0512"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PPCDC" reversible="false" name="phosphopantothenoylcysteine decarboxylase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_4ppcys[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pan4p[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv1391"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PPCKr" reversible="true" name="phosphoenolpyruvate carboxykinase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_oaa[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pep[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv0211"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PPCOAC" reversible="false" name="Propionyl-CoA carboxylase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_hco3[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ppcoa[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_mmcoa-S[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:or>
            <fbc:and>
              <fbc:geneProductRef fbc:geneProduct="G_Rv3285"/>
              <fbc:geneProductRef fbc:geneProduct="G_Rv0974c"/>
            </fbc:and>
            <fbc:and>
              <fbc:geneProductRef fbc:geneProduct="G_Rv0973c"/>
              <fbc:geneProductRef fbc:geneProduct="G_Rv0974c"/>
            </fbc:and>
            <fbc:and>
              <fbc:geneProductRef fbc:geneProduct="G_Rv2501c"/>
              <fbc:geneProductRef fbc:geneProduct="G_Rv2247"/>
            </fbc:and>
            <fbc:and>
              <fbc:geneProductRef fbc:geneProduct="G_Rv0973c"/>
              <fbc:geneProductRef fbc:geneProduct="G_Rv2502c"/>
            </fbc:and>
          </fbc:or>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PPCSCT" reversible="false" name="Propanoyl-CoA: succinate CoA-transferase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_ppcoa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_succ[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ppa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_succoa[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_PPDIMAS" reversible="false" name="PPDIM synthesis (Mycobacterium Tuberculosis)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_pphthiocerol[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_tamocta[c]" stoichiometry="2"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_ppdima[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2941"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PPDIMAT" reversible="false" name="ppdima translocase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_ppdima[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ppdima[e]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2945c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PPDK" reversible="false" name="Pyruvate,phosphate dikinase." fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pyr[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_amp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pep[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv1127c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PPGKr" reversible="true" name="Polyphosphate glucokinase reversible" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_glc-D[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_g6p[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2702"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PPK2" reversible="false" name="polyphosphate kinase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pppi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2984"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PPNCL" reversible="false" name="phosphopantothenate-cysteine ligase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_4ppan[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ctp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_cys-L[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_4ppcys[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_cdp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv1391"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PPNCL2" reversible="false" name="phosphopantothenate-cysteine ligase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_4ppan[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ctp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_cys-L[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_4ppcys[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_cmp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv1391"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PPNCL3" reversible="false" name="phosphopantothenate-cysteine ligase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_4ppan[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_cys-L[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_4ppcys[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_amp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv1391"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PPND" reversible="false" name="prephenate dehydrogenase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_nad[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pphn[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_34hpp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadh[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv3754"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PPNDH" reversible="false" name="prephenate dehydratase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pphn[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_phpyr[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv3838c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PPPGO" reversible="false" name="protoporphyrinogen oxidase (aerobic)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_o2[c]" stoichiometry="1.5"/>
          <speciesReference constant="true" species="M_pppg9[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="3"/>
          <speciesReference constant="true" species="M_ppp9[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2677c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PPTGS" reversible="false" name="Peptidoglycan subunit synthesis" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_uaagmda[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_peptido_EC[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_udcpdp[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2163c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PPTGS_TB1" reversible="false" name="Peptidoglycan subunit synthesis" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_uaaAgla[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_peptido_TB1[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_udcpdp[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2163c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PPTGS_TB2" reversible="false" name="Peptidoglycan subunit synthesis" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_uaaGgla[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_peptido_TB2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_udcpdp[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2163c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PRAGSr" reversible="true" name="phosphoribosylglycinamide synthase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_gly[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pram[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_gar[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv0772"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PRAIS" reversible="false" name="phosphoribosylaminoimidazole synthase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_fpram[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_air[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv0809"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PRAIi" reversible="false" name="phosphoribosylanthranilate isomerase (irreversible)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_pran[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_2cpr5p[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv1603"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PRAMPC" reversible="false" name="phosphoribosyl-AMP cyclohydrolase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_prbamp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_prfp[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv1606"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PRASCS" reversible="true" name="phosphoribosylaminoimidazolesuccinocarboxamide synthase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_5aizc[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_asp-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_25aics[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv0780"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PRATPP" reversible="false" name="phosphoribosyl-ATP pyrophosphatase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_prbatp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_prbamp[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2122c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PRDX" reversible="false" name="Peroxidase (multiple substrates)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h2o2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_meoh[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_fald[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="2"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv1908c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PREPHACPH" reversible="false" name="fatty-acyl-ACP hydrolase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_prephthACP[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ACP[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_prephth[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2928"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PREPPACPH" reversible="false" name="fatty-acyl-ACP hydrolase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_prepphthACP[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ACP[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_prepphth[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2928"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PREPTHS" reversible="false" name="phthiocerol precursor synthesis" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_arachACP[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="14"/>
          <speciesReference constant="true" species="M_malcoa[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_mmcoa-S[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_nadph[c]" stoichiometry="10"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_coa[c]" stoichiometry="4"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="5"/>
          <speciesReference constant="true" species="M_nadp[c]" stoichiometry="10"/>
          <speciesReference constant="true" species="M_prephthACP[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_Rv2932"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv2933"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv2931"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv2935"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv2934"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PREPTHS2" reversible="false" name="phenolic phthiocerol precursor synthesis" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="14"/>
          <speciesReference constant="true" species="M_malcoa[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_mmcoa-S[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_nadph[c]" stoichiometry="10"/>
          <speciesReference constant="true" species="M_phdcaACP[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_coa[c]" stoichiometry="4"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="5"/>
          <speciesReference constant="true" species="M_nadp[c]" stoichiometry="10"/>
          <speciesReference constant="true" species="M_prepphthACP[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_Rv2932"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv2933"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv2931"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv2935"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv2934"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PREPTTA" reversible="true" name="phthiocerol precursor ACP transacylase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_ACP[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_prephthcoa[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_coa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_prephthACP[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_PRFGS" reversible="false" name="phosphoribosylformylglycinamidine synthase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_fgam[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_gln-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_fpram[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_glu-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_Rv0788"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv0803"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PRMICIi" reversible="false" name=" 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide isomerase (irreversible)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_prfp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_prlp[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv1603"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PROD2" reversible="false" name="Proline dehydrogenase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_fad[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pro-L[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_1pyr5c[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_fadh2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv1188"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PROabc" reversible="false" name="L-proline transport via ABC system" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pro-L[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pro-L[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_Rv3757c"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv3759c"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv3756c"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv3758c"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PROt2r" reversible="true" name="L-proline reversible transport via proton symport" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[e]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pro-L[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pro-L[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_PRPPS" reversible="true" name="phosphoribosylpyrophosphate synthetase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_r5p[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_amp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_prpp[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv1017c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PSCVT" reversible="true" name=" 3-phosphoshikimate 1-carboxyvinyltransferase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_pep[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_skm5p[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_3psme[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv3227"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PSD160" reversible="false" name="Phosphatidylserine decarboxylase (n-C16:0)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ps160[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pe160[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv0437c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PSD180" reversible="false" name="Phosphatidylserine decarboxylase (n-C18:0)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ps180[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pe180[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv0437c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PSERT" reversible="false" name="phosphoserine transaminase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_3php[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_glu-L[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_akg[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pser-L[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv0884c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PSP_L" reversible="false" name="phosphoserine phosphatase (L-serine)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pser-L[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ser-L[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:or>
            <fbc:geneProductRef fbc:geneProduct="G_Rv0505c"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv3042c"/>
          </fbc:or>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PSSA160" reversible="false" name="Phosphatidylserine syntase (n-C16:0)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_cdpdhdecg[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ser-L[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_cmp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ps160[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv0436c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PSSA180" reversible="false" name="Phosphatidylserine syntase (n-C18:0)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_cdpdodecg[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ser-L[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_cmp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ps180[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv0436c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PTAr" reversible="true" name="phosphotransacetylase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_accoa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_actp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_coa[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv0408"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PTPATi" reversible="false" name="pantetheine-phosphate adenylyltransferase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pan4p[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_dpcoa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2965c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PUNP1" reversible="true" name="purine-nucleoside phosphorylase (Adenosine)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_adn[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ade[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_r1p[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv3307"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PUNP2" reversible="true" name="purine-nucleoside phosphorylase (Deoxyadenosine)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_dad-2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_2dr1p[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ade[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv3307"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PUNP3" reversible="true" name="purine-nucleoside phosphorylase (Guanosine)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_gsn[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_gua[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_r1p[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv3307"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PUNP4" reversible="true" name="purine-nucleoside phosphorylase (Deoxyguanosine)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_dgsn[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_2dr1p[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_gua[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv3307"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PUNP5" reversible="true" name="purine-nucleoside phosphorylase (Inosine)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_ins[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_hxan[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_r1p[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv3307"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PUNP6" reversible="true" name="purine-nucleoside phosphorylase (Deoxyinosine)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_din[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_2dr1p[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_hxan[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv3307"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PUNP7" reversible="true" name="purine-nucleoside phosphorylase (Xanthosine)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_xtsn[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_r1p[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_xan[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv3307"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PYAM5PO" reversible="false" name="pyridoxamine 5&apos;-phosphate oxidase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_o2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pyam5p[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h2o2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nh4[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pydx5p[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2607"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PYDXNO" reversible="true" name="pyridoxine oxidase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_o2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pydxn[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h2o2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pydx[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2607"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PYDXO" reversible="true" name="pyridoxal oxidase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_nh4[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_o2[c]" stoichiometry="0.5"/>
          <speciesReference constant="true" species="M_pydx[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h2o2[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_pydam[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2607"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PYK" reversible="false" name="pyruvate kinase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pep[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pyr[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv1617"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PYRDC" reversible="false" name="pyruvate decarboxylase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pyr[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_acald[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv0162c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PYRt2r" reversible="true" name="pyruvate reversible transport via proton symport" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[e]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pyr[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pyr[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv1902c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_QRr" reversible="true" name="Quinone reductase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadph[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_q[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_nadp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_qh2[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv3777"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_QULNS" reversible="false" name="quinolinate synthase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_dhap[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_iasp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_quln[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv1594"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_R05217" reversible="false" name="Precorrin 3A + Oxygen &lt;=&gt; Precorrin 3B" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_o2[c]" stoichiometry="0.5"/>
          <speciesReference constant="true" species="M_pre3a[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_pre3b[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2064"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_R05219" reversible="false" name="Precorrin 5 &lt;=&gt; Precorrin 6X" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_amet[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pre5[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ac[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ahcys[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pre6a[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_R05224" reversible="false" name="Hydrogenobyrinate  &lt;=&gt; Hydrogenobyrinate a,c diamide" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_gln-L[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_hgbyr[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_glu-L[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_hgbam[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2848c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_RBFK" reversible="false" name="riboflavin kinase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ribflv[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_fmn[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2786c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_RBFSa" reversible="false" name="riboflavin synthase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_4r5au[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_db4p[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_dmlz[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1412"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1416"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_RBFSb" reversible="false" name="riboflavin synthase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_dmlz[c]" stoichiometry="2"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_4r5au[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ribflv[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1412"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1416"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_RBK" reversible="false" name="ribokinase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_rib-D[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_r5p[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2436"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_RBK_Dr" reversible="true" name="D-ribulokinase (reversible)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_rbl-D[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ru5p-D[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_RBK_L1r" reversible="true" name="L-ribulokinase (L-ribulose) (reversible)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_rbl-L[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ru5p-L[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_RIBabc" reversible="false" name="D-ribose transport via ABC system" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_rib-D[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_rib-D[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1237"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1236"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1238"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_RNDR1" reversible="false" name="ribonucleoside-diphosphate reductase (ADP)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_trdrd[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_dadp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_trdox[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1981c"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv0570"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_RNDR2" reversible="false" name="ribonucleoside-diphosphate reductase (GDP)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_gdp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_trdrd[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_dgdp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_trdox[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:or>
            <fbc:and>
              <fbc:geneProductRef fbc:geneProduct="G_Rv3048c"/>
              <fbc:geneProductRef fbc:geneProduct="G_Rv3051c"/>
            </fbc:and>
            <fbc:and>
              <fbc:geneProductRef fbc:geneProduct="G_Rv3048c"/>
              <fbc:geneProductRef fbc:geneProduct="G_Rv3051c"/>
            </fbc:and>
          </fbc:or>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_RNDR3" reversible="false" name="ribonucleoside-diphosphate reductase (CDP)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_cdp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_trdrd[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_dcdp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_trdox[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:or>
            <fbc:and>
              <fbc:geneProductRef fbc:geneProduct="G_Rv3048c"/>
              <fbc:geneProductRef fbc:geneProduct="G_Rv3051c"/>
            </fbc:and>
            <fbc:and>
              <fbc:geneProductRef fbc:geneProduct="G_Rv3048c"/>
              <fbc:geneProductRef fbc:geneProduct="G_Rv3051c"/>
            </fbc:and>
          </fbc:or>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_RNDR4" reversible="false" name="ribonucleoside-diphosphate reductase (UDP)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_trdrd[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_udp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_dudp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_trdox[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1981c"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv0570"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_RNTR4" reversible="false" name="ribonucleoside-triphosphate reductase (UTP)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_trdrd[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_utp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_dutp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_trdox[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_RPE" reversible="true" name="ribulose 5-phosphate 3-epimerase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_ru5p-D[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_xu5p-D[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv1408"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_RPI" reversible="true" name="ribose-5-phosphate isomerase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_r5p[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ru5p-D[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2465c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_RPPDIMAS" reversible="false" name="rhamnose phenol phthiocerol dimycocerosate synthesis" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_dtdprmn[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ppdima[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_dtdp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_rppdima[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2962c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_RRPPDIMAS" reversible="false" name="rhamnose rhamnose phenol phthiocerol dimycocerosate synthesis" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_dtdprmn[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_rppdima[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_dtdp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_rrppdima[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2958c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_RZ5PP" reversible="false" name="alpha-ribazole 5-phosphate phosphatase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_5prdmbz[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_rdmbzi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv3113"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_SADH" reversible="false" name="Succinylarginine dihydrolase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_sucarg[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nh4[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_sucorn[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_SADT" reversible="false" name="sulfate adenylyltransferase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_so4[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_aps[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1286"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1285"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_SADT2" reversible="false" name="Sulfate adenyltransferase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_gtp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_so4[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_aps[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_gdp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1286"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1285"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_SALCS" reversible="false" name="salicylate synthase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_chor[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_pyr[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_salc[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2386c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_SDPDS" reversible="false" name="succinyl-diaminopimelate desuccinylase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_sl26da[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_26dap-LL[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_succ[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv1202"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_SDPTA" reversible="true" name="succinyldiaminopimelate transaminase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_akg[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_sl26da[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_glu-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_sl2a6o[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv0858c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_SELCYSLY" reversible="false" name="selenocysteine lyase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_dtt[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_selcys[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ala-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_dttOX[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_seln[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv1464"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_SERAT" reversible="true" name="serine O-acetyltransferase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_accoa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ser-L[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_acser[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_coa[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2335"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_SERD_D" reversible="false" name="D-serine deaminase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_ser-D[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_nh4[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pyr[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv0069c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_SERD_L" reversible="false" name="L-serine deaminase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_ser-L[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_nh4[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pyr[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv0069c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_SERt2r" reversible="true" name="L-serine reversible transport via proton symport" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[e]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ser-L[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ser-L[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv1704c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_SGDS" reversible="false" name="Succinylglutamate desuccinylase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_sucglu[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_glu-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_succ[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_SGSAD" reversible="false" name="Succinylglutamic semialdehyde dehydrogenase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nad[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_sucgsa[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_nadh[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_sucglu[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_SHCHCS" reversible="false" name=" 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_ichor[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_sucsal[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_2shchc[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pyr[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv0555"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_SHCHCS2" reversible="false" name=" 2-succinyl-6-hydroxy-2,4-cyclohexadiene 1-carboxylate synthase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_ichor[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ssaltpp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_2shchc[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pyr[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_thmpp[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv0555"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_SHCHD2" reversible="false" name="sirohydrochlorin dehydrogenase (NAD)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_dscl[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nad[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadh[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_scl[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2847c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_SHCHD3" reversible="false" name="sirohydrochlorin dehydrogenase (NAD)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_nad[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pre2[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadh[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_scl2[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2847c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_SHCHF" reversible="false" name="sirohydrochlorin ferrochelatase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_fe2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_scl[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="3"/>
          <speciesReference constant="true" species="M_sheme[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2847c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_SHCHF2" reversible="false" name="sirohydrochlorin ferrochelatase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_fe2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_scl2[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_sheme[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2847c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_SHCHF3" reversible="false" name="sirohydrochlorin ferrochelatase (mycobactin)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_fmcbtt[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_scl[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="3"/>
          <speciesReference constant="true" species="M_mcbtt[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_sheme[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_SHK3Dr" reversible="true" name="shikimate dehydrogenase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_3dhsk[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadph[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_nadp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_skm[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2552c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_SHKK" reversible="false" name="shikimate kinase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_skm[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_skm5p[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2539c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_SHSL1r" reversible="true" name="O-succinylhomoserine lyase reversible" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_cys-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_suchms[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_cyst-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_succ[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_Rv0391"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1079"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_SHSL4r" reversible="true" name="O-succinylhomoserine lyase (elimination), reversible" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_suchms[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_2obut[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nh4[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_succ[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_Rv0391"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1079"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_SKMt2" reversible="true" name="shikimate transport in via proton symport" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[e]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_skm[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_skm[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv1200"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_SOTA" reversible="false" name="Succinylornithine transaminase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_akg[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_sucorn[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_glu-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_sucgsa[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_SPMS" reversible="false" name="spermidine synthase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_ametam[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ptrc[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_5mta[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_spmd[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2601"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_SPODM" reversible="false" name="superoxide dismutase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_o2s[c]" stoichiometry="2"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h2o2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_o2[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:or>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1908c"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv0432"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv3846"/>
          </fbc:or>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_SSALx" reversible="false" name="succinate-semialdehyde dehydrogenase (NAD)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nad[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_sucsal[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_nadh[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_succ[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1731"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv0234c"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_SSALy" reversible="false" name="succinate-semialdehyde dehydrogenase (NADP)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_sucsal[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_nadph[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_succ[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:or>
            <fbc:geneProductRef fbc:geneProduct="G_Rv0234c"/>
            <fbc:and>
              <fbc:geneProductRef fbc:geneProduct="G_Rv1731"/>
              <fbc:geneProductRef fbc:geneProduct="G_Rv0234c"/>
            </fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1731"/>
          </fbc:or>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_SUCBZL" reversible="false" name="o-succinylbenzoate-CoA ligase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_coa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_sucbz[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_amp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_sbzcoa[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv0542c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_SUCBZS" reversible="false" name="O-succinylbenzoate-CoA synthase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_2shchc[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_sucbz[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv0553"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_SUCCt2r" reversible="true" name="succinate transport via proton symport" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[e]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_succ[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_succ[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2443"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_SUCD1i" reversible="false" name="succinate dehydrogenase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_fad[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_succ[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_fadh2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_fum[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:or>
            <fbc:and>
              <fbc:geneProductRef fbc:geneProduct="G_Rv3319"/>
              <fbc:geneProductRef fbc:geneProduct="G_Rv3317"/>
              <fbc:geneProductRef fbc:geneProduct="G_Rv3316"/>
              <fbc:geneProductRef fbc:geneProduct="G_Rv3318"/>
            </fbc:and>
            <fbc:and>
              <fbc:geneProductRef fbc:geneProduct="G_Rv0248c"/>
              <fbc:geneProductRef fbc:geneProduct="G_Rv3317"/>
              <fbc:geneProductRef fbc:geneProduct="G_Rv3316"/>
              <fbc:geneProductRef fbc:geneProduct="G_Rv3318"/>
            </fbc:and>
            <fbc:and>
              <fbc:geneProductRef fbc:geneProduct="G_Rv3317"/>
              <fbc:geneProductRef fbc:geneProduct="G_Rv3316"/>
              <fbc:geneProductRef fbc:geneProduct="G_Rv0247c"/>
              <fbc:geneProductRef fbc:geneProduct="G_Rv3318"/>
            </fbc:and>
          </fbc:or>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_SUCOAS" reversible="true" name="succinyl-CoA synthetase (ADP-forming)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_coa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_succ[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_succoa[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_Rv0951"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv0952"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_SULR" reversible="true" name="sulfite reductase (NADPH2)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="3"/>
          <speciesReference constant="true" species="M_h2s[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadp[c]" stoichiometry="3"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="5"/>
          <speciesReference constant="true" species="M_nadph[c]" stoichiometry="3"/>
          <speciesReference constant="true" species="M_so3[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_SULabc" reversible="false" name="sulfate transport via ABC system" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_so4[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_so4[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:or>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1739c"/>
            <fbc:and>
              <fbc:geneProductRef fbc:geneProduct="G_Rv2397c"/>
              <fbc:geneProductRef fbc:geneProduct="G_Rv2400c"/>
              <fbc:geneProductRef fbc:geneProduct="G_Rv2399c"/>
              <fbc:geneProductRef fbc:geneProduct="G_Rv2398c"/>
            </fbc:and>
          </fbc:or>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_TALA" reversible="true" name="transaldolase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_g3p[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_s7p[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_e4p[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_f6p[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv1448c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_TARTD" reversible="false" name="L(+)-tartrate dehydratase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_tartr-L[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_oaa[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_TARTRt7" reversible="true" name="Tartrate/succinate antiporter" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_succ[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_tartr-L[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_succ[e]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_tartr-L[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv1672c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_TAS" reversible="false" name="tetra-arabinofuranoside synthesis" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_arab-D[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_decda_tb[c]" stoichiometry="3"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_decd_tb[c]" stoichiometry="3"/>
          <speciesReference constant="true" species="M_tarab-D[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_TATS" reversible="false" name="tetra-acyl trehalose synthesis" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="4"/>
          <speciesReference constant="true" species="M_hdca[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_hpmtria[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_omtta[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_tre[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="4"/>
          <speciesReference constant="true" species="M_tat[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_TATSO" reversible="false" name="tetra-acyl trehalose sulfate (sulfolipid-1) synthesis" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="4"/>
          <speciesReference constant="true" species="M_hdca[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_hpmtria[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_omtta[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_tres[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="4"/>
          <speciesReference constant="true" species="M_sl1[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_TDMS1" reversible="false" name="trehalose dimycolate synthesis" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_mmycolate[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_mycolate[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_tre[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_tdm1[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_TDMS2" reversible="false" name="trehalose dimycolate synthesis" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_mmmycolate[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_mycolate[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_tre[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_tdm2[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_TDMS3" reversible="false" name="trehalose dimycolate synthesis" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_mkmycolate[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_mycolate[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_tre[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_tdm3[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_TDMS4" reversible="false" name="trehalose dimycolate synthesis" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_kmycolate[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_mycolate[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_tre[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_tdm4[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_TDPDRE" reversible="false" name="dTDP-4-dehydrorhamnose 3,5-epimerase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_dtdp4d6dg[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_dtdp4d6dm[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv3465"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_TDPDRR" reversible="false" name="dTDP-4-dehydrorhamnose reductase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_dtdp4d6dm[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadph[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_dtdprmn[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadp[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv3266c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_TDPGDH" reversible="false" name="dTDPglucose 4,6-dehydratase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_dtdpglu[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_dtdp4d6dg[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:or>
            <fbc:geneProductRef fbc:geneProduct="G_Rv3784"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv3468c"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv3464"/>
          </fbc:or>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_THD1" reversible="true" name="NAD(P) transhydrogenase (B-specific)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_nad[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadph[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_nadh[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadp[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2713"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_THDPS" reversible="false" name="tetrahydrodipicolinate succinylase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_succoa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_thdp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_coa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_sl2a6o[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv1201c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_THFGLUS" reversible="true" name="Tetrahydrofolate:L-glutamate gamma-ligase (ADP-forming)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_glu-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_thf[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_thfglu[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2447c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_THMDP" reversible="false" name="thiamin diphosphatase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_thmpp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_thm[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv3113"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_THRD_Lr" reversible="true" name="L-threonine deaminse reversible" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_thr-L[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_2obut[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nh4[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv1559"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_THRS" reversible="false" name="threonine synthase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_phom[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_thr-L[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv1295"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_THRt2r" reversible="true" name="L-threonine reversible transport via proton symport" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[e]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_thr-L[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_thr-L[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv3737"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_THSFST" reversible="true" name="Thiosulfate Sulfurtransferase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_cyan[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_tsul[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_so3[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_tcynt[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2291"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_THZPSN" reversible="false" name="thiazole phosphate synthesis" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_cys-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_dxyl5p[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_tyr-L[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_4hba[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_4mpetz[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ala-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_amp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv0417"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_THZSN" reversible="false" name="thiazole synthesis from xylulose" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_cys-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_dxyl[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_tyr-L[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_4hba[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_4mhetz[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nh4[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pyr[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv0417"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_TKT1" reversible="true" name="transketolase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_r5p[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_xu5p-D[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_g3p[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_s7p[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv1449c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_TKT2" reversible="true" name="transketolase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_e4p[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_xu5p-D[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_f6p[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_g3p[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv1449c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_TMDK1" reversible="false" name="thymidine kinase (ATP:thymidine)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_thymd[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_dtmp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_TMDPP" reversible="true" name="thymidine phosphorylase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_thymd[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_2dr1p[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_thym[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv3314c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_TMDS" reversible="false" name="thymidylate synthase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_dump[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_mlthf[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_dhf[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_dtmp[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:or>
            <fbc:geneProductRef fbc:geneProduct="G_Rv2754c"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv2764c"/>
          </fbc:or>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_TMHAS1" reversible="false" name="trehalose dimycolate synthesis" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_tdm1[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_tdm2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_tre[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_tmha1[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_TMHAS2" reversible="false" name="trehalose dimycolate synthesis" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_tdm1[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_tdm3[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_tre[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_tmha2[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_TMHAS3" reversible="false" name="trehalose dimycolate synthesis" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_tdm1[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_tdm4[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_tre[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_tmha3[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_TMHAS4" reversible="false" name="trehalose dimycolate synthesis" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_tdm2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_tdm3[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_tre[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_tmha4[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_TMHAS5" reversible="false" name="trehalose dimycolate synthesis" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_tdm2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_tdm4[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_tre[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_tmha5[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_TMHAS6" reversible="false" name="trehalose dimycolate synthesis" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_tdm3[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_tdm4[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_tre[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_tmha6[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_TMN" reversible="false" name="thiaminase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_thm[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_4ahmmp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_4mhetz[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_TMPKr" reversible="true" name="thiamine-phosphate kinase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_thmmp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_thmpp[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2977c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_TMPPP" reversible="false" name="thiamine-phosphate diphosphorylase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_2mahmp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_4mpetz[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_thmmp[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv0414c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_TPI" reversible="true" name="triose-phosphate isomerase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_dhap[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_g3p[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv1438"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_TRDR" reversible="false" name="thioredoxin reductase (NADPH)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadph[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_trdox[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_nadp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_trdrd[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv3913"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_TRE6PP" reversible="false" name="trehalose-phosphatase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_tre6p[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_tre[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_Rv3372"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv2006"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_TRE6PS" reversible="false" name="alpha,alpha-trehalose-phosphate synthase (UDP-forming)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_g6p[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_udpg[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_tre6p[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_udp[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv3490"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_TRESULT" reversible="false" name="trehalose sulfotransferase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_paps[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_tre[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pap[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_tres[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:or>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1373"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv0295c"/>
          </fbc:or>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_TREabc" reversible="false" name="trehalose  transport via ABC system" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_tre[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_tre[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1237"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1236"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1238"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_TRIATS" reversible="false" name="tri-acyl trehalose sulfonation" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="3"/>
          <speciesReference constant="true" species="M_ocdca[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_tmlgnc[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_tre[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="3"/>
          <speciesReference constant="true" species="M_triat[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_TRPS1" reversible="false" name="tryptophan synthase (indoleglycerol phosphate)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_3ig3p[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ser-L[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_g3p[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_trp-L[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1613"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1612"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_TRPS2" reversible="false" name="tryptophan synthase (indole)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_indole[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ser-L[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_trp-L[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1613"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1612"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_TRPS3" reversible="false" name="tryptophan synthase (indoleglycerol phosphate)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_3ig3p[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_g3p[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_indole[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1613"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1612"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_TRPTA" reversible="true" name="tryptophan transaminase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_akg[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_trp-L[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_glu-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_indpyr[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_TRPt2r" reversible="true" name="L-tryptophan reversible transport via proton symport" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[e]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_trp-L[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_trp-L[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_TSULabc" reversible="false" name="thiosulfate transport via ABC system" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_tsul[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_tsul[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:or>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1739c"/>
            <fbc:and>
              <fbc:geneProductRef fbc:geneProduct="G_Rv2397c"/>
              <fbc:geneProductRef fbc:geneProduct="G_Rv2400c"/>
              <fbc:geneProductRef fbc:geneProduct="G_Rv2399c"/>
              <fbc:geneProductRef fbc:geneProduct="G_Rv2398c"/>
            </fbc:and>
          </fbc:or>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_TTDCAt2" reversible="false" name="Tetradecanoate transport via proton symport" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[e]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ttdca[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ttdca[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_TYRTA" reversible="true" name="tyrosine transaminase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_akg[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_tyr-L[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_34hpp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_glu-L[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_TYRt2r" reversible="true" name="L-tyrosine reversible transport via proton symport" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[e]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_tyr-L[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_tyr-L[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_UAAGDS" reversible="false" name="UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelate synthetase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_26dap-M[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_uamag[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ugmd[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2158c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_UAAGLS1" reversible="false" name="UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-lysine synthetase (alpha-glutamate)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_lys-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_uamag[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_uAgl[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_UAAGLS2" reversible="false" name="UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine synthetase (gamma-glutamate)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_lys-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_uamag[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_uGgl[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_UAGCVT" reversible="false" name="UDP-N-acetylglucosamine 1-carboxyvinyltransferase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_pep[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_uacgam[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_uaccg[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv1315"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_UAGDP" reversible="false" name="UDP-N-acetylglucosamine diphosphorylase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_acgam1p[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_utp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_uacgam[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv1018c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_UAGPT1" reversible="false" name="UDP-N-acetylglucosamine-N-acetylmuramyl-(pentapeptide)pyrophosphoryl-undecaprenol N-acetylglucosamine transferase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_uaAgla[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_uacgam[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_uaaAgla[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_udp[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2153c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_UAGPT2" reversible="false" name="UDP-N-acetylglucosamine-N-acetylmuramyl-(pentapeptide)pyrophosphoryl-undecaprenol N-acetylglucosamine transferase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_uaGgla[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_uacgam[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_uaaGgla[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_udp[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2153c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_UAGPT3" reversible="false" name="UDP-N-acetylglucosamine-N-acetylmuramyl-(pentapeptide)pyrophosphoryl-undecaprenol N-acetylglucosamine transferase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_uacgam[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_uagmda[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_uaagmda[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_udp[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2153c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_UAMAGS" reversible="false" name="UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_glu-D[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_uama[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_uamag[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2155c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_UAMAS" reversible="false" name="UDP-N-acetylmuramoyl-L-alanine synthetase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_ala-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_uamr[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_uama[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2152c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_UAMRH" reversible="false" name="UDP-MurNAc Hydroxylase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadph[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_o2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_uamr[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ugmr[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv3818"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_UAPGR" reversible="false" name="UDP-N-acetylenolpyruvoylglucosamine reductase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadph[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_uaccg[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_nadp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_uamr[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv0482"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_UDCPDP" reversible="false" name="undecaprenyl-diphosphatase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_udcpdp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_udcpp[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2136c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_UDCPDPS" reversible="false" name="Undecaprenyl diphosphate synthase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_frdp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ipdp[c]" stoichiometry="8"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="8"/>
          <speciesReference constant="true" species="M_udcpdp[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_UDPDPS" reversible="false" name="undecaprenyl-diphosphate synthase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_decdp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ipdp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_udcpdp[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2361c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_UDPDPS2" reversible="false" name="undecaprenyl-diphosphate synthase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_decdp_tb[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ipdp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_udcpdp[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2361c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_UDPG4E" reversible="true" name="UDPglucose 4-epimerase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_udpg[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_udpgal[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:or>
            <fbc:geneProductRef fbc:geneProduct="G_Rv0501"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv0536"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv3634c"/>
          </fbc:or>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_UDPGALM" reversible="false" name="UDPgalactopyranose mutase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_udpgal[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_udpgalfur[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv3809c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_UDPGD" reversible="false" name="UDPglucose 6-dehydrogenase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nad[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_udpg[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="3"/>
          <speciesReference constant="true" species="M_nadh[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_udpglcur[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv0322"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_UGAGDS" reversible="false" name="UDP-N-glycolylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelate synthetase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_26dap-M[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ugmag[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_uggmd[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2158c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_UGGPT3" reversible="false" name="UDP-N-glycolylglucosamine-N-acetylmuramyl-(pentapeptide)pyrophosphoryl-undecaprenol N-acetylglucosamine transferase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_uacgam[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ugggmda[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_udp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ugagmda[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2153c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_UGLDDS1" reversible="false" name="UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine synthetase (alpha-glutamate)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_alaala[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_uAgl[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_uAgla[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2157c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_UGLDDS2" reversible="false" name="UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine synthetase (gamma-glutamate)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_alaala[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_uGgl[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_uGgla[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2157c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_UGMAGS" reversible="false" name="UDP-N-glycolylmuramoyl-L-alanyl-D-glutamate synthetase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_glu-D[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ugma[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ugmag[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2155c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_UGMAS" reversible="false" name="UDP-N-glycolylmuramoyl-L-alanine synthetase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_ala-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ugmr[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ugma[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2152c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_UGMDDS" reversible="false" name="UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine synthetase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_alaala[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ugmd[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ugmda[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2157c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_UGMDDS2" reversible="false" name="UDP-N-glycolylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine synthetase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_alaala[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_uggmd[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_uggmda[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2157c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_UMPK" reversible="true" name="UMP kinase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ump[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_udp[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv1712"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_UPP3MT" reversible="false" name="uroporphyrinogen methyltransferase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_amet[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_uppg3[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ahcys[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_dscl[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2847c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_UPP3S" reversible="false" name="uroporphyrinogen-III synthase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_hmbil[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_uppg3[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv0511"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_UPPDC1" reversible="false" name="uroporphyrinogen decarboxylase (uroporphyrinogen III)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="4"/>
          <speciesReference constant="true" species="M_uppg3[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="4"/>
          <speciesReference constant="true" species="M_cpppg3[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2678c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_UPPDC2" reversible="false" name="uroporphyrinogen decarboxylase (uroporphyrinogen I)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="4"/>
          <speciesReference constant="true" species="M_uppg1[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="4"/>
          <speciesReference constant="true" species="M_cpppg1[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2678c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_UPPRT" reversible="false" name="uracil phosphoribosyltransferase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_prpp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ura[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ump[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv3309c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_UREA" reversible="false" name="urease" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_urea[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nh4[c]" stoichiometry="2"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1848"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1850"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1849"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_URIDK1" reversible="false" name="uridylate kinase (UMP)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ump[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_udp[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2883c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_URIDK2r" reversible="true" name="uridylate kinase (dUMP)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_dump[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_dudp[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_URIK2" reversible="false" name="uridine kinase (GTP:Uridine)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_gtp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_uri[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_gdp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ump[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_VALTA" reversible="true" name="valine transaminase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_akg[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_val-L[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_3mob[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_glu-L[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv2210c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_VALt2r" reversible="true" name="L-valine reversible transport via proton symport" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[e]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_val-L[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_val-L[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_XPPT" reversible="false" name="xanthine phosphoribosyltransferase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_prpp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_xan[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_xmp[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_XYLK" reversible="false" name="xylulokinase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_xylu-D[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_xu5p-D[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv0729"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_XYLabc" reversible="false" name="D-xylose transport via ABC system" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_xyl-D[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_xyl-D[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1237"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1236"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1238"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_YUMPS" reversible="true" name="yUMP synthetase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_r5p[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ura[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_psd5p[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_Rv3455c"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv2793c"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_Chol_deg_sup_1" reversible="true" name="cholesterol- O2 oxidoreductase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_cholest[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nad[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_o2[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_cholest-4-en-3-one[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadh[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv3409c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_Chol_deg_sup_2" reversible="false" name="Side-chain monooxygenase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_cholest-4-en-3-one[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadh[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_o2[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_26-hydroxy-4-cholesten-3-one[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nad[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv3518c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_Chol_deg_sup_3" reversible="false" name="Side-chain monooxygenase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_26-hydroxy-4-cholesten-3-one[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nad[c]" stoichiometry="2"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_26-carboxy-4-cholesten-3-one[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_nadh[c]" stoichiometry="2"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:or>
            <fbc:geneProductRef fbc:geneProduct="G_Rv3518c"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv3545"/>
          </fbc:or>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_Chol_deg_sup_4" reversible="false" name="cholesterol CoA synthase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_26-carboxy-4-cholesten-3-one[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_coa[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_4-cholesten-3-one-coa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_amp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:or>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1153"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv3561"/>
          </fbc:or>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_Chol_deg_sup_5" reversible="false" name="thiolase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_4-cholesten-3-one-coa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_coa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_fad[c]" stoichiometry="3"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_nad[c]" stoichiometry="2"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_17,20-dehydro-4-cholesten-3-one-coa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_accoa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_fadh2[c]" stoichiometry="3"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_nadh[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_ppcoa[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv3140"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_Chol_deg_sup_6" reversible="false" name="enoyl-CoA hydratase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_17,20-dehydro-4-cholesten-3-one-coa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_androst-4-ene-3,17-dione[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ppcoa[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:or>
            <fbc:geneProductRef fbc:geneProduct="G_Rv1472"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv0860"/>
          </fbc:or>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_Chol_deg_sup_7" reversible="false" name="steroid degrading rieske monooxygenase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_androst-4-ene-3,17-dione[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadh[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_o2[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_9-OHADD[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nad[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:or>
            <fbc:geneProductRef fbc:geneProduct="G_Rv3571"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv3526"/>
          </fbc:or>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_Chol_deg_sup_8" reversible="false" name="3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4,5-dioxygenase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_9-OHADD[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_o2[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_3-hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv3568"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_Chol_deg_sup_9" reversible="false" name="BPHD" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_3-hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_2-hydroxyhexa-2,4,-dienoate[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_DOHNAA[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_Rv3569c"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_Chol_deg_sup_10" reversible="false" name="hydratase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_2-hydroxyhexa-2,4,-dienoate[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_coa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nad[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadh[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ppcoa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pyr[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:or>
            <fbc:geneProductRef fbc:geneProduct="G_Rv3536c"/>
            <fbc:geneProductRef fbc:geneProduct="G_Rv3535c"/>
          </fbc:or>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_EX_cholest(e)" reversible="true" name="Cholesterol exchange" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="R_EX_cholest(e)_lower_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_cholest[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_cholest[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_biomass_Mtb_9_60atp" reversible="false" name="biomass composition for Mycobacterium tuberculosis (v 0.1) - 60 atp" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_Ac1PIM1[c]" stoichiometry="0.001681"/>
          <speciesReference constant="true" species="M_Ac1PIM2[c]" stoichiometry="0.001488"/>
          <speciesReference constant="true" species="M_Ac1PIM3[c]" stoichiometry="0.001335"/>
          <speciesReference constant="true" species="M_Ac1PIM4[c]" stoichiometry="0.001211"/>
          <speciesReference constant="true" species="M_Ac2PIM2[c]" stoichiometry="0.001274"/>
          <speciesReference constant="true" species="M_PIM1[c]" stoichiometry="0.002076"/>
          <speciesReference constant="true" species="M_PIM2[c]" stoichiometry="0.00179"/>
          <speciesReference constant="true" species="M_PIM3[c]" stoichiometry="0.001573"/>
          <speciesReference constant="true" species="M_PIM4[c]" stoichiometry="0.001403"/>
          <speciesReference constant="true" species="M_PIM5[c]" stoichiometry="0.001266"/>
          <speciesReference constant="true" species="M_PIM6[c]" stoichiometry="0.001154"/>
          <speciesReference constant="true" species="M_acgam1p[c]" stoichiometry="0.23018"/>
          <speciesReference constant="true" species="M_ala-L[c]" stoichiometry="0.40596"/>
          <speciesReference constant="true" species="M_amp[c]" stoichiometry="0.13903"/>
          <speciesReference constant="true" species="M_arabinanagalfragund[c]" stoichiometry="0.000731"/>
          <speciesReference constant="true" species="M_arach[c]" stoichiometry="0.015676"/>
          <speciesReference constant="true" species="M_arg-L[c]" stoichiometry="0.12042"/>
          <speciesReference constant="true" species="M_asn-L[c]" stoichiometry="0.047699"/>
          <speciesReference constant="true" species="M_asp-L[c]" stoichiometry="0.12031"/>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="60"/>
          <speciesReference constant="true" species="M_clpn160190[c]" stoichiometry="0.005859"/>
          <speciesReference constant="true" species="M_cmp[c]" stoichiometry="0.25095"/>
          <speciesReference constant="true" species="M_cys-L[c]" stoichiometry="0.022"/>
          <speciesReference constant="true" species="M_damp[c]" stoichiometry="0.003492"/>
          <speciesReference constant="true" species="M_dcmp[c]" stoichiometry="0.006663"/>
          <speciesReference constant="true" species="M_dgmp[c]" stoichiometry="0.006659"/>
          <speciesReference constant="true" species="M_dtmp[c]" stoichiometry="0.003653"/>
          <speciesReference constant="true" species="M_fcmcbtt[c]" stoichiometry="0.001498"/>
          <speciesReference constant="true" species="M_gal[c]" stoichiometry="0.055474"/>
          <speciesReference constant="true" species="M_glc-D[c]" stoichiometry="0.3263"/>
          <speciesReference constant="true" species="M_gln-L[c]" stoichiometry="0.05812"/>
          <speciesReference constant="true" species="M_glu-L[c]" stoichiometry="0.090007"/>
          <speciesReference constant="true" species="M_gly[c]" stoichiometry="0.33581"/>
          <speciesReference constant="true" species="M_glyc[c]" stoichiometry="0.025359"/>
          <speciesReference constant="true" species="M_gmp[c]" stoichiometry="0.24365"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="60"/>
          <speciesReference constant="true" species="M_hdca[c]" stoichiometry="0.23515"/>
          <speciesReference constant="true" species="M_hdcea[c]" stoichiometry="0.01094"/>
          <speciesReference constant="true" species="M_hexc[c]" stoichiometry="0.058352"/>
          <speciesReference constant="true" species="M_his-L[c]" stoichiometry="0.040617"/>
          <speciesReference constant="true" species="M_ile-L[c]" stoichiometry="0.087731"/>
          <speciesReference constant="true" species="M_kmycolate[c]" stoichiometry="0.003338"/>
          <speciesReference constant="true" species="M_leu-L[c]" stoichiometry="0.20471"/>
          <speciesReference constant="true" species="M_lys-L[c]" stoichiometry="0.03909"/>
          <speciesReference constant="true" species="M_man[c]" stoichiometry="0.095065"/>
          <speciesReference constant="true" species="M_mbhn[c]" stoichiometry="0.00784"/>
          <speciesReference constant="true" species="M_mcbts[c]" stoichiometry="0.001402"/>
          <speciesReference constant="true" species="M_met-L[c]" stoichiometry="0.034889"/>
          <speciesReference constant="true" species="M_mfrrppdima[c]" stoichiometry="0.001184"/>
          <speciesReference constant="true" species="M_mkmycolate[c]" stoichiometry="0.003291"/>
          <speciesReference constant="true" species="M_mmmycolate[c]" stoichiometry="0.003365"/>
          <speciesReference constant="true" species="M_mocdca[c]" stoichiometry="0.095802"/>
          <speciesReference constant="true" species="M_mycolate[c]" stoichiometry="0.011003"/>
          <speciesReference constant="true" species="M_ocdca[c]" stoichiometry="0.034837"/>
          <speciesReference constant="true" species="M_ocdcea[c]" stoichiometry="0.009849"/>
          <speciesReference constant="true" species="M_pa160190[c]" stoichiometry="0.006798"/>
          <speciesReference constant="true" species="M_pa160[c]" stoichiometry="0.00724"/>
          <speciesReference constant="true" species="M_pa190190[c]" stoichiometry="0.006407"/>
          <speciesReference constant="true" species="M_pat[c]" stoichiometry="0.001251"/>
          <speciesReference constant="true" species="M_pdima[c]" stoichiometry="0.000273"/>
          <speciesReference constant="true" species="M_pe160[c]" stoichiometry="0.004061"/>
          <speciesReference constant="true" species="M_peptido_TB1[c]" stoichiometry="0.01885"/>
          <speciesReference constant="true" species="M_peptido_TB2[c]" stoichiometry="0.01885"/>
          <speciesReference constant="true" species="M_pg160190[c]" stoichiometry="0.00613"/>
          <speciesReference constant="true" species="M_pg160[c]" stoichiometry="0.006487"/>
          <speciesReference constant="true" species="M_pg190[c]" stoichiometry="0.00581"/>
          <speciesReference constant="true" species="M_phdca[c]" stoichiometry="0.006453"/>
          <speciesReference constant="true" species="M_phe-L[c]" stoichiometry="0.048102"/>
          <speciesReference constant="true" species="M_ppdima[c]" stoichiometry="0.000263"/>
          <speciesReference constant="true" species="M_pro-L[c]" stoichiometry="0.13803"/>
          <speciesReference constant="true" species="M_rib-D[c]" stoichiometry="0.021723"/>
          <speciesReference constant="true" species="M_ser-L[c]" stoichiometry="0.1434"/>
          <speciesReference constant="true" species="M_sl1[c]" stoichiometry="0.001137"/>
          <speciesReference constant="true" species="M_tat[c]" stoichiometry="0.001176"/>
          <speciesReference constant="true" species="M_thr-L[c]" stoichiometry="0.13571"/>
          <speciesReference constant="true" species="M_tmha1[c]" stoichiometry="0.001106"/>
          <speciesReference constant="true" species="M_tmha2[c]" stoichiometry="0.0011"/>
          <speciesReference constant="true" species="M_tmha3[c]" stoichiometry="0.001104"/>
          <speciesReference constant="true" species="M_tmha4[c]" stoichiometry="0.001097"/>
          <speciesReference constant="true" species="M_tre6p[c]" stoichiometry="0.006491"/>
          <speciesReference constant="true" species="M_tre[c]" stoichiometry="0.00797"/>
          <speciesReference constant="true" species="M_tres[c]" stoichiometry="0.006474"/>
          <speciesReference constant="true" species="M_trp-L[c]" stoichiometry="0.020124"/>
          <speciesReference constant="true" species="M_ttdca[c]" stoichiometry="0.012193"/>
          <speciesReference constant="true" species="M_tyr-L[c]" stoichiometry="0.031756"/>
          <speciesReference constant="true" species="M_uaaAgla[c]" stoichiometry="0.001008"/>
          <speciesReference constant="true" species="M_uaaGgla[c]" stoichiometry="0.001008"/>
          <speciesReference constant="true" species="M_uaagmda[c]" stoichiometry="0.000986"/>
          <speciesReference constant="true" species="M_uamr[c]" stoichiometry="0.002793"/>
          <speciesReference constant="true" species="M_ugagmda[c]" stoichiometry="0.000977"/>
          <speciesReference constant="true" species="M_ump[c]" stoichiometry="0.1316"/>
          <speciesReference constant="true" species="M_val-L[c]" stoichiometry="0.20583"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="60"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="60"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="60"/>
        </listOfProducts>
      </reaction>
    </listOfReactions>
  </model>
</sbml>