HGVS.p	GT	Continent	REF	ALT	count	proportion	Genetic_variants_renamed	Position	low_n_label
p.Glu454Lys	0	Africa	C	T	37	1	reference	454	NA
p.Glu454Lys	0	Asia	C	T	1	1	reference	454	NA
p.Glu454Lys	0	Europe	C	T	1640	1	reference	454	NA
p.Glu454Lys	0	Middle East	C	T	80	1	reference	454	NA
p.Glu454Lys	0	North America	C	T	209	0.995238095	reference	454	NA
p.Glu454Lys	0	Oceania	C	T	135	1	reference	454	NA
p.Glu454Lys	0	South America	C	T	50	1	reference	454	NA
p.Glu454Lys	1	North America	C	T	1	0.004761905	Most frequent Alt	454	<5
p.Leu4Val	0	Africa	G	C	37	1	reference	4	NA
p.Leu4Val	0	Asia	G	C	1	1	reference	4	NA
p.Leu4Val	0	Europe	G	C	1640	1	reference	4	NA
p.Leu4Val	0	Middle East	G	C	78	0.975	reference	4	NA
p.Leu4Val	0	North America	G	C	210	1	reference	4	NA
p.Leu4Val	0	Oceania	G	C	135	1	reference	4	NA
p.Leu4Val	0	South America	G	C	50	1	reference	4	NA
p.Leu4Val	1	Middle East	G	C	2	0.025	Most frequent Alt	4	<5
p.Tyr459del	.	Europe	CATA	"*,C"	5	0.00304878	missing	459	<5
p.Tyr459del	.	Oceania	CATA	"*,C"	1	0.007407407	missing	459	<5
p.Tyr459del	0	Africa	CATA	"*,C"	37	1	reference	459	NA
p.Tyr459del	0	Asia	CATA	"*,C"	1	1	reference	459	NA
p.Tyr459del	0	Europe	CATA	"*,C"	975	0.594512195	reference	459	NA
p.Tyr459del	0	Middle East	CATA	"*,C"	80	1	reference	459	NA
p.Tyr459del	0	North America	CATA	"*,C"	210	1	reference	459	NA
p.Tyr459del	0	Oceania	CATA	"*,C"	64	0.474074074	reference	459	NA
p.Tyr459del	0	South America	CATA	"*,C"	50	1	reference	459	NA
p.Tyr459del	1	Europe	CATA	"*,C"	656	0.4	Most frequent Alt	459	NA
p.Tyr459del	1	Oceania	CATA	"*,C"	70	0.518518519	Most frequent Alt	459	NA
p.Tyr459del	2	Europe	CATA	"*,C"	4	0.002439024	Less frequent Alt	459	<5
p.Tyr461Ser	.	Europe	TAGCCATA	"GAGCCATA,*"	1	0.000609756	missing	461	<5
p.Tyr461Ser	0	Africa	TAGCCATA	"GAGCCATA,*"	35	0.945945946	reference	461	NA
p.Tyr461Ser	0	Asia	TAGCCATA	"GAGCCATA,*"	1	1	reference	461	NA
p.Tyr461Ser	0	Europe	TAGCCATA	"GAGCCATA,*"	806	0.491463415	reference	461	NA
p.Tyr461Ser	0	Middle East	TAGCCATA	"GAGCCATA,*"	80	1	reference	461	NA
p.Tyr461Ser	0	North America	TAGCCATA	"GAGCCATA,*"	210	1	reference	461	NA
p.Tyr461Ser	0	Oceania	TAGCCATA	"GAGCCATA,*"	46	0.340740741	reference	461	NA
p.Tyr461Ser	0	South America	TAGCCATA	"GAGCCATA,*"	50	1	reference	461	NA
p.Tyr461Ser	1	Africa	TAGCCATA	"GAGCCATA,*"	1	0.027027027	Less frequent Alt	461	<5
p.Tyr461Ser	1	Europe	TAGCCATA	"GAGCCATA,*"	140	0.085365854	Less frequent Alt	461	NA
p.Tyr461Ser	1	Oceania	TAGCCATA	"GAGCCATA,*"	18	0.133333333	Less frequent Alt	461	NA
p.Tyr461Ser	2	Africa	TAGCCATA	"GAGCCATA,*"	1	0.027027027	Most frequent Alt	461	<5
p.Tyr461Ser	2	Europe	TAGCCATA	"GAGCCATA,*"	693	0.422560976	Most frequent Alt	461	NA
p.Tyr461Ser	2	Oceania	TAGCCATA	"GAGCCATA,*"	71	0.525925926	Most frequent Alt	461	NA
									
"Table S5. Allele frequency data for CYP51 mutations across continents. Raw counts and frequencies of G450R, L4V, Y461S, _Y459/G460, E454K, and G516D alleles in 2,156 Zymoseptoria tritici isolates grouped by continent. Columns provide the number of isolates carrying reference, alternative, or missing calls for each locus. The column ÒPositionÓ, correspond to the amino acid position in Cyp51. The column Òlow_n_labelÓ is <5 when the frequency is lower than 5% or NAÓ."