Aggregate figure source package validation report
Date: 2026-08-13

Scope
- Statistical estimates: unchanged from the verified round-2 analysis.
- Documentation: updated to state that bootstrap-sample and original-cohort
  performance are averaged separately across five imputation indices before
  resample-specific optimism is calculated.
- Patient-level data: not included.
- Aggregate source CSV files: retained from the verified round-2 results.
- Figure regeneration scripts: corrected and tested.

Automated checks passed
- Required Figure 2 source files and columns were found.
- Figure 2 contained exactly three biomarker rows, three model rows, and one M2-M0 comparison row.
- Figure S3 contained 297 coordinates (99 probabilities for each of M0, M1, and M2).
- Every Figure S3 corrected curve coordinate lay within its corresponding 95% confidence band.
- All released figure-source files were described in DATA_DICTIONARY.csv.
- 00_regenerate_submitted_figures.R completed successfully under R 4.6.1.
- Figure 2 and Figure S3 were regenerated as PDF, PNG, and TIFF.
- Figure 2 was pixel-identical to the corresponding final round-2 reference
  TIFF. Figure S3 was regenerated successfully from the released coordinates;
  minor raster-level differences may occur across R and graphics environments.

Notes
- PDF binary checksums and rasterization may differ because PDF metadata,
  fonts, and graphics environments can vary; released source coordinates and
  validation summaries were unchanged.
- The locale warnings emitted by the local R installation did not affect file creation or the rendered figures.
