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["Association between interleukin-2 cytokine levels and Plasmodium infections: A systematic review and meta-analysis\nPattamaporn Kwankaew1, Kwuntida Uthaisar Kotepui2, Nsoh Godwin Anabire3,4, Polrat Wilairatana5, Manas Kotepui2*\n\n1 Medical Technology, School of Allied Health Sciences, Walailak University, Tha Sala, Nakhon Si Thammarat, Thailand\n2 Medical Technology Program, Faculty of Science, Nakhon Phanom University, Nakhon Phanom 48000, Thailand\n3 Department of Biochemistry & Molecular Medicine, School of Medicine, University for Development studies, Tamale, Ghana.\n4 West African Centre for Cell Biology of Infectious Pathogens (WACCBIP); Department of Biochemistry, Cell & Molecular Biology, University of Ghana, Accra, Ghana.\n5 Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand\n\n*Corresponding author\nManas Kotepui: manaskote@gmail, Tel.: +66954392469\nPolrat Wilairatana: polrat.wil@mahidol.ac.th\nNsoh Godwin Anabire: nanabire@uds.edu.gh\nPattamaporn Kwankaew: pattamaporn.kw@wu.ac.th\nKwuntida Uthaisar Kotepui: kwuntida.ut@wu.ac.th\n"]
["Table S3. Quality of the included studies"]
["JBI CRITICAL APPRAISAL CHECKLIST FOR ANALYTICAL CROSS SECTIONAL STUDIES"]
["No.","Study","1. Were the criteria for inclusion in the sample clearly defined?","2. Were the study subjects and the setting described in detail?","3. Was the exposure measured in a valid and reliable way?","4. Were objective, standard criteria used for measurement of the condition?","5. Were confounding factors identified?","6. Were strategies to deal with confounding factors stated?","7. Were the outcomes measured in a valid and reliable way?","8. Was appropriate statistical analysis used?","Overall appraisal: "]
[1,"Anabire et al., 2019","Yes","Yes","Yes","Yes","Yes","Yes","Yes","Yes","Include"]
[2,"Armah et al., 2007","Yes","Yes","Yes","Yes","No","No","Yes","Yes","Include"]
[3,"Baptista et al., 1997","Yes","Yes","Yes","Yes","No","No","Yes","Yes","Include"]
[4,"Chaves et al., 2016","Yes","Yes","Yes","Yes","No","No","Yes","Yes","Include"]
[5,"Coelho et al., 2013","Yes","Yes","Yes","Yes","Yes","Yes","Yes","Yes","Include"]
[6,"Mandala et al., 2017","Yes","Yes","Yes","Yes","No","No","Yes","Yes","Include"]
[7,"Mendonça et al., 2015","Yes","Yes","Yes","Yes","Yes","Yes","Yes","Yes","Include"]
[8,"Ong'echa et al., 2011 ","Yes","Yes","Yes","Yes","Yes","Yes","Yes","Yes","Include"]
[9,"Scherer et al., 2016","Yes","Yes","Yes","Yes","No","No","Yes","Yes","Include"]
[10,"Singotamu et al., 2006","Yes","Yes","Yes","Yes","Yes","Yes","Yes","Yes","Include"]
[11,"Tatfeng et al., 2012","Yes","Yes","Yes","Yes","Yes","Yes","Yes","Yes","Include"]
[12,"Wilson et al., 2010","Yes","Yes","No","Yes","Yes","No","Yes","Yes","Include"]
[13,"Menezes et al., 2018","Yes","Yes","Yes","Yes","Yes","Yes","Yes","Yes","Include"]
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["JBI CRITICAL APPRAISAL CHECKLIST FOR CASE CONTROL STUDIES"]
["No.","Study","1. Were the groups comparable other than the presence of disease in cases or the absence of disease in controls?","2. Were cases and controls matched appropriately?","3. Were the same criteria used for identification of cases and controls?","4. Was exposure measured in a standard, valid and reliable way?","5. Was exposure measured in the same way for cases and controls?","6. Were confounding factors identified? ","7. Were strategies to deal with confounding factors stated?","8. Were outcomes assessed in a standard, valid and reliable way for cases and controls?","9. Was the exposure period of interest long enough to be meaningful?","10. Was appropriate statistical analysis used?","Overall appraisal: "]
[1,"da Costa et al., 2014 ","Yes","Yes","Yes","Yes","Yes","No","No","Yes","Yes","Yes","Include"]
[2,"Frimpong et al., 2022 ","Yes","Yes","Yes","Yes","Yes","No","No","Yes","Yes","Yes","Include"]
[3,"Kremsner et al., 1990","Yes","Yes","Yes","Yes","Yes","No","No","Yes","Yes","Yes","Include"]
[4,"Perera et al., 2013","Yes","Yes","Yes","Yes","Yes","No","No","Yes","Yes","Yes","Include"]
[5,"Prakash et al., 2006","Yes","Yes","Yes","Yes","Yes","Yes","Yes","Yes","Yes","Yes","Include"]
[6,"Rovira-Vallbona et al., 2012","Yes","Yes","Yes","Yes","Yes","Yes","Yes","Yes","Yes","Yes","Include"]
[7,"Zeyrek et al., 2006","Yes","Yes","Yes","Yes","Yes","No","No","Yes","Yes","Yes","Include"]
[8,"Tatfeng and Agbonlahor 2008","Yes","Yes","Yes","Yes","Yes","No","No","Yes","Yes","Yes","Include"]
[9,"Tatfeng and Agbonlahor 2010","Yes","Yes","Yes","Yes","Yes","No","No","Yes","Yes","Yes","Include"]
[10,"de Jesus et al., 2023","Yes","Yes","Yes","Yes","Yes","No","No","Yes","Yes","Yes","Include"]
[11,"Obeng-Aboagye et al., 2023","Yes","Yes","Yes","Yes","Yes","Yes","Yes","Yes","Yes","Yes","Include"]
[12,"Rabiu et al., 2022","Yes","Yes","Yes","Yes","Yes","Yes","Yes","Yes","Yes","Yes","Include"]
[13,"Bin Eric et al., 2024","Yes","Yes","Yes","Yes","Yes","Yes","Yes","Yes","Yes","Yes","Include"]
[14,"van den Bogaart et al., 2014","Yes","Yes","Yes","Yes","Yes","Yes","Yes","Yes","Yes","Yes","Include"]
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["CHECKLIST FOR  COHORT STUDIES"]
["No.","Study","1. Were the two groups similar and recruited from the same population?","2. Were the exposures measured similarly to assign people to both exposed and unexposed groups?","3. Was the exposure measured in a valid and reliable way?","4. Were confounding factors identified?","5. Were strategies to deal with confounding factors stated?","6. Were the groups/participants free of the outcome at the start of the study (or at the moment of exposure)?","7. Were the outcomes measured in a valid and reliable way?","8. Was the follow up time reported and sufficient to be long enough for outcomes to occur?","9. Was follow up complete, and if not, were the reasons to loss to follow up described and explored?","10. Were strategies to address incomplete follow up utilized?","11. Was appropriate statistical analysis used?","Overall appraisal: "]
[1,"Jain et al., 2008","Yes","Yes","Yes","Yes","Yes","Yes","Yes","Yes","Yes","Yes","Yes","Include"]
[2,"Acero et al., 2022","Yes","Yes","Yes","Yes","Yes","Yes","Yes","Yes","Yes","Yes","Yes","Include"]
[3,"de Roquetaillade et al., 2023","Yes","Yes","Yes","Yes","Yes","Yes","Yes","Yes","Yes","Yes","Yes","Include"]

{"sheet":"Case-control studies","index":1,"n_rows":9,"n_cols":14,"rows_kept":9,"merged":[[0,0,0,12]],"flags":["formulas_cached_only"]}
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[0,"Abdullahi et al., 2021","Yes","Yes","Yes","Yes","Yes","Yes","Yes","Yes","Yes","Yes","Include"]
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[]
[]
[]
[{"$nulls":13},"Age of each group"]
[{"$nulls":13},"Physical findings"]

{"sheet":"Cohort studies","index":2,"n_rows":6,"n_cols":15,"rows_kept":6,"merged":[[0,0,0,13]],"flags":["formulas_cached_only"]}
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[0,"Das BS and Nanda NK, 1999","Yes","Yes","Yes","Yes","Yes","Yes","Yes","Yes","Yes","Yes","Yes","Include"]
[0,"Davis et al., 1994","Yes","Yes","Yes","Yes","Yes","Yes","Yes","Yes","Yes","Unclear","Yes","Include"]
[1,"Jain et al., 2008","Yes","Yes","Yes","Yes","Yes","Yes","Yes","Yes","Yes","Yes","Yes","Include","Tribal population/nontribal"]
[2,"Tovar Acero et al., 2022","Yes","Yes","Yes","Yes","Yes","Yes","Yes","Yes","Yes","Yes","Yes","Include","GOT/GPT /Creatinine/"]