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["CANCER-ASSOCIATED GENES MODULATED IN HT1376sT CELLS AS COMPARED TO HT1376T CELLS"]
["Genes differentially expressed between HT1376sT and HT1376T were selected by application of the two tail ANOVA followed by the Benjamini-Hochberg false discovery rate test with a p or q  ≤ 0.05 cut-off and by a log2 expression (log 2E) difference ≥1.0   "]
["Gene Symbol","Description","Chr","GenBank","log 2E HT1376T","log 2E HT1376sT","log 2E difference between HT1376sT and HT1376T","Fold expression change between HT1376sT and HT1376T","Role","Ref. (PubMed Identification Number)","Cellular function"]
["Changes putatively associated with increased malignancy"]
["FRMD3","ferm domain containing protein 3 ",9,"NM_174938",{"v":8.30523822097591,"d":"8.3"},{"v":5.49993802706391,"d":"5.5"},{"v":-2.805300193912,"d":"-2.8"},-7,"Putative tumor suppressor",17260017,"Apoptosis"]
["TGFB2","Transforming growth factor beta2",11,"NM_053056",8.9,6.6,-2.2,-4.6,"Tumor suppressor regulating SMAD signaling","19291273","Cell growth"]
["LOXL4","lysyl oxidase-like 4",10,"NM_032211",7.1,5.7,-1.4,-2.6,"Act as tumour suppressor by inhibiting the Ras/ERK signaling pathway","17456585","Cell growth"]
["KRT5","keratin 5",12,"NM_000424",10.4,8.6,-1.9,-3.7,"KRTs are differentially expressed during epithelial tissue differentiation","23827819; 22308455","Cytoskeleton"]
["THBS1","thrombospondin 1",15,"NM_003246",7.7,5.9,-1.8,-3.5,"Antiangiogenic factor","19662222; 19762163; 12429155; 20299037","Angiogenesis"]
["ALCAM","activated leukocyte cell adhesion molecule",3,"NM_001627",{"v":9.86733371842626,"d":"9.9"},{"v":7.59883445480719,"d":"7.6"},{"v":-2.268499263619069,"d":"-2.3"},-4.9,"Reduces invasive growth through control of metalloprotieinases","16204050; 20530423","Cell adhesion Proteolysis"]
["SERPINE2","serpin peptidase inhibitor; clade E (nexin; plasminogen activator inhibitor type 1); member 2",2,"NM_001136529",7.4,8.5,1.1,2.1,"Serine peptidase inhibitor, pleiotropic functions besides haemostasis","20942929; 20035713; 22360729","Proteolysis"]
["FRY","furry homolog (Drosophila)",13,"NM_023037",{"v":9.25838429317787,"d":"9.3"},{"v":7.98410404537723,"d":"8.0"},{"v":-1.2742802478006405,"d":"-1.3"},-2.5,"FRY is crucial for the fidelity of mitotic chromosome alignment","24023717; 19327996; 20624913","DNA stability"]
["HAUS7","HAUS augmin-like complex, subunit 7","X","NM_207107",7.9,6.5,-1.3,-2.5,"HAUS disruption results in the destabilization of kinetochore microtubules and the formation of multipolar spindles",19427217,"DNA stability"]
["KIF4A","kinesin family member 4A","X","NM_012310",9.3,8,-1.3,-2.5,"Plays an essential role for bipolar microtubule organizing centers (MTOC) formation and maintaining chromosomal stability during mitosis","20711700; 18502200; 18604178","DNA stability"]
["KIFC1","kinesin family member C1",6,"NM_002263",9.4,8.1,-1.2,-2.3,"Plays an essential role for bipolar microtubule organizing centers (MTOC) formation and maintaining chromosomal stability during mitosis","23318213","DNA stability"]
["CCNF","cyclin F",16,"NM_001761",9,7.9,-1.1,-2.1,"Fine-tunes centrosome duplication and DNA synthesis, preventing chromosome instability","23182110; 22632967; 23486064","DNA stability"]
["CDCA5","cell division cycle associated 5",11,"NM_080668",8.5,7.4,-1.1,-2.1,"Involved in maintenance of cohesion in response to the spindle checkpoint","17361102; 21878504; 21115494","DNA stability"]
["SPC24","SPC24, NDC80 kinetochore complex component, homolog (S. cerevisiae)",19,"NM_182513",8.4,7.3,-1.1,-2.1,"Required to establish and maintain kinetochore-microtubule attachment","14738735; 16765893","DNA stability"]
["FANCG","Fanconi anemia; complementation group G",9,"NM_004629",8.2,7.2,-1,-2,"Prevents accumulation  of double-strand breaks and preserves chromosome stability","18000367; 18212739","DNA stability"]
["CDC20","cell division cycle 20 homolog (S. cerevisiae)",1,"NM_001255",11.3,10.3,-1,-2,"Involved in maintenance of cohesion in response to the spindle checkpoint","28260099; 28238542","DNA stability"]
["CENPM","centromere protein M",22,"NM_024053",8.4,7.4,-1,-2,"Centromeric protein",28167779,"DNA stability"]
["CENPE","centromere protein F, 350/400ka (mitosin)",1,"NM_016343",10.1,9.1,-1,-2,"Centromeric protein",27735937,"DNA stability"]
["Changes putatively associated with decreased malignancy"]
["SH3BGRL","SH3 domain binding glutamic acid-rich protein like","X","NM_003022",6.4,8.1,1.7,3.2,"Tumor suppressor. Inhibits v-rel-mediated transformation",16186799,"Cell growth "]
["CCND1","cyclin D1",11,"NM_053056",9,7.6,-1.4,-2.6,"G(1)-phase cell cycle regulatory molecule"," 23887292","Cell growth"]
["TPTE","transmembrane phosphatase with tensin homology",21,"NM_199261",5.2,6.4,1.2,2.3,"PTEN-related tyrosine phosphatase","20043944; 20491626\n","Cell growth"]
["AIM2","Absent in melanoma 2",1,"NM_004833",4.3,5.6,1.3,2.5,"Suppress tumor growth through inihibition of NFkB signaling",25879280,"Inflammation"]
["SERPINE1","serpin peptidase inhibitor; clade E (nexin; plasminogen activator inhibitor type 1); member 1",7,"NM_000602",9.6,7.3,-2.3,-4.9,"Serine peptidase inhibitor, pleiotropic functions besides haemostasis ","23052373; 23764080","Proteolysis"]
["ADAM12","ADAM metallopeptidase domain 12",10,"NM_003474",8.6,7,-1.5,-2.8,"A disintegrin and metalloprotease, multifunctional zinc-dependent metzincin protease ","17189408","Proteolysis"]
["ANTXR1","anthrax toxin receptor 1",2,"NM_032208",{"v":8.57830362130174,"d":"8.6"},{"v":6.91838392574674,"d":"6.9"},{"v":-1.6599196955550006,"d":"-1.7"},-3.2,"Associated with cancer stem cell phenotype. Overexpressed in breast cancers",23832666,"Cell adhesion"]
["OLFML3","olfactomedin-like 3",1,"NM_020190",9,6.6,-2.5,-5.7,"Promotes angiogenesis","23002094","Angiogenesis"]
["RHOXF2","Rhox homeobox family, member 2","X","NM_032498",8.1,5.4,-2.7,-6.5,"Associated with cell growth in various tumors",21874235,"Gene expression"]
["LGALS1","lectin, galactoside-binding, soluble, 1",22,"NM_002305",{"v":10.7451950846556,"d":"10.7"},{"v":9.28839965572726,"d":"9.3"},{"v":-1.4567954289283414,"d":"-1.5"},2.8,"Strong inducer of T cells apoptosis","19365409; 15630413","Immune regulation"]
["SLC39A2","solute carrier family 39 (zinc transporter), member 2",14,"NM_014579",6.8,9,2.2,4.6,"Tumor suppressor",17550612,"Ionic homeostasis"]
["STC1","stanniocalcin 1",8,"NM_003155",7.5,5.5,-2,-4,"Induced by hypoxia, is associated with invasive growth in different cancers","25391215; 25400427; 25740019 ","Ionic homeostasis"]
["LY6E","lymphocyte antigen 6 complex, locus E",8,"NM_002346",8,6.2,-1.8,-3.5,"Overexpressed in various solid tumors",25862760,"Unclear"]
["RAI14","retinoic acid induced 14",5,"NM_001145525",9.2,7.6,-1.7,-3.2,"Its knockdown reduces cell proliferation","25742747; 23590835","Unclear"]

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