{"text_format":"3","workbook":"xls","n_sheets":1,"sheets":["KEGG"],"read":"whole","date_system":"1900","formulas":"cached_only"}

{"sheet":"KEGG","index":0,"n_rows":127,"n_cols":9,"rows_kept":127,"flags":["formulas_cached_only"]}
["Supplementary Table 4: Results of KEGG pathyway analysis of LICMGs"]
["ID","Description","GeneRatio","BgRatio","pvalue","p.adjust","qvalue","geneID","Count"]
["hsa04015","Rap1 signaling pathway","37/432","210/8165",{"v":5.85676924350386e-11,"d":"5.86E-11"},{"v":1.76874431153817e-08,"d":"1.77E-08"},{"v":1.06038348408702e-08,"d":"1.06E-08"},"PRKCB/RASGRP3/MAGI1/EFNA5/PLCB1/PARD3/IGF1R/GNAQ/VAV1/ID1/LPAR1/PIK3CD/DOCK4/APBB1IP/RAPGEF1/FYB1/LCP2/CSF1R/ITGAM/VAV3/TIAM1/ITGB2/ENAH/RAPGEF5/PRKD1/MAGI3/EGFR/RALA/INSR/SIPA1L1/PDGFC/PRKCA/SKAP1/ITGAL/AKT3/EVL/RAP1A",37]
["hsa04145","Phagosome","30/432","152/8165",{"v":2.37147266944406e-10,"d":"2.37E-10"},{"v":3.58092373086053e-08,"d":"3.58E-08"},{"v":2.14680683760199e-08,"d":"2.15E-08"},"CD36/DYNC1I1/MSR1/MRC1/HLA-DRA/HLA-DRB1/TLR2/HLA-DPB1/CLEC7A/HLA-DPA1/FCGR2C/HLA-DQB1/HLA-DMB/CYBB/HLA-DQA1/FCGR2A/ITGAM/NCF2/ITGB2/TFRC/CTSL/ATP6V1B2/COLEC12/SCARB1/CTSS/STX7/HLA-B/HLA-A/HLA-C/HLA-E",30]
["hsa04380","Osteoclast differentiation","26/432","128/8165",{"v":2.03313051559414e-09,"d":"2.03E-09"},{"v":2.04668471903143e-07,"d":"2.05E-07"},{"v":1.22701210063927e-07,"d":"1.23E-07"},"PLCG2/BLNK/PPP3CC/PIK3CD/SYK/GRB2/MITF/LCP2/CSF1R/FCGR2C/SPI1/FCGR2A/SIRPA/TYROBP/NCF2/GAB2/STAT1/PPARG/FYN/CAMK4/LCK/NFATC2/SQSTM1/AKT3/JAK1/CYLD",26]
["hsa04611","Platelet activation","25/432","124/8165",{"v":4.92067245889651e-09,"d":"4.92E-09"},{"v":3.10646909765075e-07,"d":"3.11E-07"},{"v":1.86236557963029e-07,"d":"1.86E-07"},"PLCG2/PLCB1/PLA2G4A/GNAQ/PIK3CD/SYK/ITPR2/APBB1IP/COL1A1/ITPR1/COL1A2/PRKG1/COL3A1/TBXAS1/LCP2/PIK3R5/FCGR2A/LYN/GNA13/FYN/AKT3/RASGRP1/RAP1A/ARHGEF1/STIM1",25]
["hsa04062","Chemokine signaling pathway","32/432","192/8165",{"v":5.14316075769992e-09,"d":"5.14E-09"},{"v":3.10646909765075e-07,"d":"3.11E-07"},{"v":1.86236557963029e-07,"d":"1.86E-07"},"PLCG2/GNG7/PRKCB/DOCK2/PLCB1/GNGT1/PARD3/GNAQ/ELMO1/VAV1/PIK3CD/PTK2B/GRB2/FOXO3/HCK/PIK3R5/PREX1/FGR/ARRB2/VAV3/GNB4/TIAM1/GRK3/JAK2/LYN/STAT1/ITK/GNG2/PTK2/AKT3/RAP1A/STAT5B",32]
["hsa04658","Th1 and Th2 cell differentiation","21/432","92/8165",{"v":8.41559919487873e-09,"d":"8.42E-09"},{"v":4.23585159475563e-07,"d":"4.24E-07"},{"v":2.53944396757744e-07,"d":"2.54E-07"},"MAML3/PPP3CC/HLA-DRA/HLA-DRB1/HLA-DPB1/HLA-DPA1/HLA-DQB1/HLA-DMB/HLA-DQA1/CD4/JAK2/RBPJ/STAT1/CD247/STAT4/PRKCQ/LCK/NFATC2/JAK1/STAT5B/NFATC3",21]
["hsa05140","Leishmaniasis","19/432","77/8165",{"v":1.10858542071157e-08,"d":"1.11E-08"},{"v":4.78275424364134e-07,"d":"4.78E-07"},{"v":2.8673186821412e-07,"d":"2.87E-07"},"PRKCB/ITGA4/HLA-DRA/HLA-DRB1/TLR2/HLA-DPB1/HLA-DPA1/FCGR2C/HLA-DQB1/HLA-DMB/CYBB/HLA-DQA1/FCGR2A/ITGAM/NCF2/ITGB2/JAK2/STAT1/JAK1",19]
["hsa04612","Antigen processing and presentation","19/432","78/8165",{"v":1.39512065793027e-08,"d":"1.40E-08"},{"v":5.26658048368676e-07,"d":"5.27E-07"},{"v":3.15737833110534e-07,"d":"3.16E-07"},"CIITA/CTSB/HLA-DRA/CD74/HLA-DRB1/HLA-DPB1/HLA-DPA1/HLA-DQB1/HLA-DMB/HLA-DQA1/CD4/CTSL/CTSS/LGMN/B2M/HLA-B/HLA-A/HLA-C/HLA-E",19]
["hsa04514","Cell adhesion molecules","27/432","157/8165",{"v":4.2744922373584e-08,"d":"4.27E-08"},{"v":1.43432961742471e-06,"d":"1.43E-06"},{"v":8.59897853597245e-07,"d":"8.60E-07"},"ITGA4/PTPRM/PTPRC/CLDN10/PECAM1/ITGA6/VCAN/HLA-DRA/HLA-DRB1/CD86/HLA-DPB1/HLA-DPA1/HLA-DQB1/HLA-DMB/HLA-DQA1/ITGAM/CD4/ITGB2/ALCAM/CD58/CD2/ITGAL/CD6/HLA-B/HLA-A/HLA-C/HLA-E",27]
["hsa05166","Human T-cell leukemia virus 1 infection","33/432","222/8165",{"v":5.40530972207064e-08,"d":"5.41E-08"},{"v":1.63240353606533e-06,"d":"1.63E-06"},{"v":9.78645549680158e-07,"d":"9.79E-07"},"ATM/PPP3CC/PIK3CD/CREB3L2/MAP3K1/HLA-DRA/HLA-DRB1/HLA-DPB1/HLA-DPA1/HLA-DQB1/SPI1/HLA-DMB/HLA-DQA1/CD4/CREB5/ITGB2/NRP1/VAC14/ITGAL/ETS1/LCK/B2M/NFATC2/HLA-B/AKT3/HLA-A/KAT2B/CCND3/HLA-C/JAK1/HLA-E/STAT5B/NFATC3",33]
["hsa05152","Tuberculosis","29/432","180/8165",{"v":5.97829595754082e-08,"d":"5.98E-08"},{"v":1.6413139810703e-06,"d":"1.64E-06"},{"v":9.83987468609589e-07,"d":"9.84E-07"},"BCL2/PPP3CC/SYK/CASP10/CIITA/MRC1/ITGAX/HLA-DRA/CD74/HLA-DRB1/TLR2/HLA-DPB1/CLEC7A/HLA-DPA1/FCGR2C/HLA-DQB1/HLA-DMB/HLA-DQA1/FCGR2A/ITGAM/IL10RA/IL18/ITGB2/JAK2/CTSD/CTSS/STAT1/AKT3/JAK1",29]
["hsa04725","Cholinergic synapse","22/432","113/8165",{"v":8.11175851380922e-08,"d":"8.11E-08"},{"v":1.93020810483241e-06,"d":"1.93E-06"},{"v":1.1571829697845e-06,"d":"1.16E-06"},"GNG7/PRKCB/BCL2/PLCB1/GNGT1/GNAQ/KCNQ5/PIK3CD/ITPR2/KCNQ3/CREB3L2/CACNA1C/ITPR1/PIK3R5/CREB5/GNB4/JAK2/PRKCA/FYN/CAMK4/GNG2/AKT3",22]
["hsa04660","T cell receptor signaling pathway","21/432","104/8165",{"v":8.30884283537129e-08,"d":"8.31E-08"},{"v":1.93020810483241e-06,"d":"1.93E-06"},{"v":1.1571829697845e-06,"d":"1.16E-06"},"PTPRC/VAV1/PPP3CC/PIK3CD/GRB2/CARD11/LCP2/CD4/VAV3/FYN/CD247/GRAP2/PRKCQ/ITK/LCK/NFATC2/AKT3/RASGRP1/CBLB/NCK2/NFATC3",21]
["hsa04659","Th17 cell differentiation","21/432","108/8165",{"v":1.64225618979344e-07,"d":"1.64E-07"},{"v":3.38708478973914e-06,"d":"3.39E-06"},{"v":2.03059806146787e-06,"d":"2.03E-06"},"IRF4/PPP3CC/HLA-DRA/HLA-DRB1/HLA-DPB1/HLA-DPA1/HLA-DQB1/HLA-DMB/HLA-DQA1/CD4/JAK2/HIF1A/STAT1/RORA/CD247/PRKCQ/LCK/NFATC2/JAK1/STAT5B/NFATC3",21]
["hsa04640","Hematopoietic cell lineage","20/432","99/8165",{"v":1.68232688232077e-07,"d":"1.68E-07"},{"v":3.38708478973914e-06,"d":"3.39E-06"},{"v":2.03059806146787e-06,"d":"2.03E-06"},"MS4A1/CD38/ITGA4/CD36/ITGA6/HLA-DRA/HLA-DRB1/CSF2RA/HLA-DPB1/CSF1R/HLA-DPA1/HLA-DQB1/HLA-DMB/HLA-DQA1/ITGAM/CD4/TFRC/CD2/IL7R/CD44",20]
["hsa04940","Type I diabetes mellitus","13/432","43/8165",{"v":1.81293098563222e-07,"d":"1.81E-07"},{"v":3.42190723538082e-06,"d":"3.42E-06"},{"v":2.0514745363733e-06,"d":"2.05E-06"},"ICA1/HLA-DRA/HLA-DRB1/CD86/HLA-DPB1/HLA-DPA1/HLA-DQB1/HLA-DMB/HLA-DQA1/HLA-B/HLA-A/HLA-C/HLA-E",13]
["hsa05330","Allograft rejection","12/432","38/8165",{"v":3.18231659249616e-07,"d":"3.18E-07"},{"v":5.54411984072405e-06,"d":"5.54E-06"},{"v":3.32376651308657e-06,"d":"3.32E-06"},"HLA-DRA/HLA-DRB1/CD86/HLA-DPB1/HLA-DPA1/HLA-DQB1/HLA-DMB/HLA-DQA1/HLA-B/HLA-A/HLA-C/HLA-E",12]
["hsa05416","Viral myocarditis","15/432","60/8165",{"v":3.30444228917327e-07,"d":"3.30E-07"},{"v":5.54411984072405e-06,"d":"5.54E-06"},{"v":3.32376651308657e-06,"d":"3.32E-06"},"HLA-DRA/HLA-DRB1/CD86/HLA-DPB1/HLA-DPA1/HLA-DQB1/HLA-DMB/HLA-DQA1/ITGB2/FYN/ITGAL/HLA-B/HLA-A/HLA-C/HLA-E",15]
["hsa04724","Glutamatergic synapse","21/432","114/8165",{"v":4.27419705937329e-07,"d":"4.27E-07"},{"v":6.79372374700386e-06,"d":"6.79E-06"},{"v":4.07291908150806e-06,"d":"4.07E-06"},"GNG7/PRKCB/PLCB1/GNGT1/PLA2G4A/GNAQ/GRIA4/SHANK2/GRIK2/PPP3CC/ITPR2/DLGAP1/CACNA1C/ITPR1/SLC1A3/GNB4/GRK3/GLUL/PRKCA/GNG2/SLC38A1",21]
["hsa04666","Fc gamma R-mediated phagocytosis","19/432","97/8165",{"v":5.69380307674342e-07,"d":"5.69E-07"},{"v":8.59764264588256e-06,"d":"8.60E-06"},{"v":5.15439015368352e-06,"d":"5.15E-06"},"PLCG2/PRKCB/INPP5D/DOCK1/PTPRC/PLA2G4A/VAV1/PIK3CD/SYK/PIP5K1B/HCK/FCGR2A/VAV3/GAB2/ASAP1/GSN/LYN/PRKCA/AKT3",19]
["hsa05135","Yersinia infection","23/432","137/8165",{"v":6.81176995565944e-07,"d":"6.81E-07"},{"v":9.79597393623405e-06,"d":"9.80E-06"},{"v":5.87280417229786e-06,"d":"5.87E-06"},"ITGA4/DOCK1/GNAQ/ELMO1/VAV1/ARHGEF28/PIK3CD/PTK2B/PIP5K1B/FN1/FYB1/LCP2/FCGR2A/CD4/IL18/VAV3/LCK/PTK2/NFATC2/AKT3/ARHGEF1/WIPF1/NFATC3",23]
["hsa05169","Epstein-Barr virus infection","29/432","202/8165",{"v":7.50636939113121e-07,"d":"7.51E-07"},{"v":1.0304197982371e-05,"d":"1.03E-05"},{"v":6.17749059939985e-06,"d":"6.18E-06"},"PLCG2/BCL2/BLNK/PIK3CD/SYK/TRAF3/HLA-DRA/HLA-DRB1/TLR2/HLA-DPB1/HLA-DPA1/HLA-DQB1/HLA-DMB/HLA-DQA1/RBPJ/LYN/CD58/STAT1/CD247/ITGAL/B2M/HLA-B/AKT3/HLA-A/CCND3/HLA-C/JAK1/CD44/HLA-E",29]
["hsa04662","B cell receptor signaling pathway","17/432","82/8165",{"v":9.7591257664619e-07,"d":"9.76E-07"},{"v":1.24383797730303e-05,"d":"1.24E-05"},{"v":7.45695824664071e-06,"d":"7.46E-06"},"PLCG2/PRKCB/INPP5D/RASGRP3/BLNK/PIK3AP1/VAV1/PPP3CC/PIK3CD/SYK/GRB2/CARD11/VAV3/LYN/NFATC2/AKT3/NFATC3",17]
["hsa05205","Proteoglycans in cancer","29/432","205/8165",{"v":1.0252205678989e-06,"d":"1.03E-06"},{"v":1.24383797730303e-05,"d":"1.24E-05"},{"v":7.45695824664071e-06,"d":"7.46E-06"},"PLCG2/PRKCB/IGF1R/VAV1/WNT5B/ESR1/PIK3CD/ITPR2/GRB2/PDCD4/GAB1/COL1A1/ITPR1/COL1A2/FN1/TLR2/PLAUR/PLAU/VAV3/TIAM1/CTSL/EGFR/HIF1A/PRKCA/PTK2/AKT3/ARHGEF1/CD44/ANK3",29]
["hsa05167","Kaposi sarcoma-associated herpesvirus infection","28/432","194/8165",{"v":1.0487610328672e-06,"d":"1.05E-06"},{"v":1.24383797730303e-05,"d":"1.24E-05"},{"v":7.45695824664071e-06,"d":"7.46E-06"},"PLCG2/GNG7/GNGT1/TCF7L2/PPP3CC/PIK3CD/SYK/ITPR2/TRAF3/ITPR1/CD86/HCK/PIK3R5/PREX1/GNB4/JAK2/LYN/HIF1A/STAT1/GNG2/NFATC2/HLA-B/AKT3/HLA-A/HLA-C/JAK1/HLA-E/NFATC3",28]
["hsa05332","Graft-versus-host disease","12/432","42/8165",{"v":1.07085388774433e-06,"d":"1.07E-06"},{"v":1.24383797730303e-05,"d":"1.24E-05"},{"v":7.45695824664071e-06,"d":"7.46E-06"},"HLA-DRA/HLA-DRB1/CD86/HLA-DPB1/HLA-DPA1/HLA-DQB1/HLA-DMB/HLA-DQA1/HLA-B/HLA-A/HLA-C/HLA-E",12]
["hsa04650","Natural killer cell mediated cytotoxicity","22/432","131/8165",{"v":1.18650826320096e-06,"d":"1.19E-06"},{"v":1.32713146476552e-05,"d":"1.33E-05"},{"v":7.9563127201e-06,"d":"7.96E-06"},"PLCG2/PRKCB/VAV1/PPP3CC/PIK3CD/SYK/PTK2B/GRB2/LCP2/TYROBP/VAV3/ITGB2/PRKCA/FYN/CD247/ITGAL/LCK/NFATC2/HLA-B/HLA-A/HLA-C/HLA-E",22]
["hsa04664","Fc epsilon RI signaling pathway","15/432","68/8165",{"v":1.86397646892709e-06,"d":"1.86E-06"},{"v":2.01043176291421e-05,"d":"2.01E-05"},{"v":1.20527801750173e-05,"d":"1.21E-05"},"PLCG2/INPP5D/PLA2G4A/VAV1/PIK3CD/SYK/GRB2/ALOX5/LCP2/VAV3/GAB2/LYN/PRKCA/FYN/AKT3",15]
["hsa05170","Human immunodeficiency virus 1 infection","29/432","212/8165",{"v":2.06407627181332e-06,"d":"2.06E-06"},{"v":2.14948632444008e-05,"d":"2.15E-05"},{"v":1.28864289928091e-05,"d":"1.29E-05"},"PLCG2/GNG7/PRKCB/BCL2/GNGT1/GNAQ/ATM/PPP3CC/PIK3CD/ITPR2/PTK2B/ITPR1/SAMHD1/TLR2/CD4/GNB4/TNFRSF1B/PRKCA/CD247/GNG2/PTK2/B2M/NFATC2/HLA-B/AKT3/HLA-A/HLA-C/HLA-E/NFATC3",29]
["hsa05163","Human cytomegalovirus infection","30/432","225/8165",{"v":2.35789784988824e-06,"d":"2.36E-06"},{"v":2.37361716888749e-05,"d":"2.37E-05"},{"v":1.42301203572202e-05,"d":"1.42E-05"},"GNG7/PRKCB/PLCB1/GNGT1/GNAQ/PPP3CC/PIK3CD/ITPR2/PTK2B/GRB2/CREB3L2/ITPR1/CREB5/IL10RA/GNB4/EGFR/GNA13/PRKCA/GNG2/PTK2/B2M/NFATC2/HLA-B/AKT3/HLA-A/HLA-C/JAK1/ARHGEF1/HLA-E/NFATC3",30]
["hsa05235","PD-L1 expression and PD-1 checkpoint pathway in cancer","17/432","89/8165",{"v":3.23818875778238e-06,"d":"3.24E-06"},{"v":3.15462259629122e-05,"d":"3.15E-05"},{"v":1.89123418111568e-05,"d":"1.89E-05"},"PPP3CC/PIK3CD/TLR2/CD4/JAK2/EGFR/EML4/HIF1A/STAT1/CD247/PRKCQ/LCK/NFATC2/AKT3/RASGRP1/JAK1/NFATC3",17]
["hsa04014","Ras signaling pathway","30/432","236/8165",{"v":6.32554768721832e-06,"d":"6.33E-06"},{"v":5.96973562981229e-05,"d":"5.97E-05"},{"v":3.57892829671563e-05,"d":"3.58E-05"},"PLCG2/GNG7/PRKCB/RASGRP3/EFNA5/GNGT1/IGF1R/PLA2G4A/RASAL2/PIK3CD/GRB2/GAB1/STK4/CSF1R/GNB4/TIAM1/GAB2/RAPGEF5/EGFR/RALA/INSR/PDGFC/PRKCA/ETS1/GNG2/AKT3/RASA3/RASGRP1/RAP1A/RASA2",30]
["hsa04670","Leukocyte transendothelial migration","19/432","114/8165",{"v":7.15336804704479e-06,"d":"7.15E-06"},{"v":6.54641560668948e-05,"d":"6.55E-05"},{"v":3.9246548774855e-05,"d":"3.92E-05"},"PLCG2/PRKCB/RHOH/ITGA4/CLDN10/PECAM1/VAV1/PIK3CD/PTK2B/CYBB/ITGAM/NCF2/VAV3/ITGB2/PRKCA/ITGAL/ITK/PTK2/RAP1A",19]
["hsa05417","Lipid and atherosclerosis","28/432","215/8165",{"v":8.14127391643788e-06,"d":"8.14E-06"},{"v":7.23136683165953e-05,"d":"7.23E-05"},{"v":4.33529137345918e-05,"d":"4.34E-05"},"POU2F2/BCL2/PLCB1/CD36/VAV1/PPP3CC/PIK3CD/TRAF3/EIF2AK3/ITPR1/XBP1/ABCA1/TLR2/ABCG1/CYBB/IL18/NCF2/VAV3/JAK2/LYN/PRKCA/PPARG/PTK2/NFATC2/AKT3/RAP1A/ARHGEF1/NFATC3",28]
["hsa04072","Phospholipase D signaling pathway","22/432","148/8165",{"v":9.42483760911893e-06,"d":"9.42E-06"},{"v":7.98795219984287e-05,"d":"7.99E-05"},{"v":4.78887339969667e-05,"d":"4.79E-05"},"PLCG2/PLCB1/PLA2G4A/LPAR1/PIK3CD/SYK/PTK2B/GRB2/PIP5K1B/GAB1/PIK3R5/CYTH4/GAB2/CYTH1/EGFR/GNA13/RALA/INSR/PDGFC/PRKCA/FYN/AKT3",22]
["hsa04928","Parathyroid hormone synthesis, secretion and action","18/432","106/8165",{"v":9.52206222497825e-06,"d":"9.52E-06"},{"v":7.98795219984287e-05,"d":"7.99E-05"},{"v":4.78887339969667e-05,"d":"4.79E-05"},"MEF2C/PRKCB/BCL2/PLCB1/GNAQ/CYP24A1/PDE4B/PDE4D/ITPR2/CREB3L2/ITPR1/ARRB2/CREB5/MEF2A/EGFR/GNA13/PRKCA/ARHGEF1",18]
["hsa01521","EGFR tyrosine kinase inhibitor resistance","15/432","79/8165",{"v":1.32425052233204e-05,"d":"1.32E-05"},0.000108087475066021,{"v":6.47997410643276e-05,"d":"6.48E-05"},"PLCG2/PRKCB/BCL2/IGF1R/PIK3CD/GRB2/GAB1/FOXO3/AXL/JAK2/EGFR/PDGFC/PRKCA/AKT3/JAK1",15]
["hsa05320","Autoimmune thyroid disease","12/432","53/8165",{"v":1.51811416759048e-05,"d":"1.52E-05"},0.000120650125950612,{"v":7.23312013367211e-05,"d":"7.23E-05"},"HLA-DRA/HLA-DRB1/CD86/HLA-DPB1/HLA-DPA1/HLA-DQB1/HLA-DMB/HLA-DQA1/HLA-B/HLA-A/HLA-C/HLA-E",12]
["hsa04933","AGE-RAGE signaling pathway in diabetic complications","17/432","100/8165",{"v":1.65746368445183e-05,"d":"1.66E-05"},0.000128347187872936,{"v":7.69456825170618e-05,"d":"7.69E-05"},"PLCG2/PRKCB/BCL2/PLCB1/F3/PIK3CD/COL1A1/COL1A2/FN1/COL3A1/CYBB/JAK2/STAT1/PRKCA/AKT3/FOXO1/STAT5B",17]
["hsa04728","Dopaminergic synapse","20/432","132/8165",{"v":1.7990683022708e-05,"d":"1.80E-05"},0.000135829656821446,{"v":8.14315126290995e-05,"d":"8.14E-05"},"GNG7/PRKCB/PLCB1/GNGT1/MAOA/GNAQ/GRIA4/PPP3CC/ITPR2/CREB3L2/CACNA1C/ITPR1/ARRB2/CREB5/GNB4/PRKCA/GNG2/AKT3/PPP2R2B/PPP2R5C",20]
["hsa05145","Toxoplasmosis","18/432","112/8165",{"v":2.08456188052628e-05,"d":"2.08E-05"},0.000150405604999312,{"v":9.01699688389046e-05,"d":"9.02E-05"},"BCL2/ITGA6/CIITA/ALOX5/HLA-DRA/HLA-DRB1/TLR2/HLA-DPB1/HLA-DPA1/PIK3R5/HLA-DQB1/HLA-DMB/HLA-DQA1/IL10RA/JAK2/STAT1/AKT3/JAK1",18]
["hsa04022","cGMP-PKG signaling pathway","23/432","167/8165",{"v":2.13149276119465e-05,"d":"2.13E-05"},0.000150405604999312,{"v":9.01699688389046e-05,"d":"9.02E-05"},"MEF2C/ATP2A3/PLCB1/ATP1B1/GNAQ/PPP3CC/ITPR2/CREB3L2/CACNA1C/ATP2B1/ITPR1/PRKG1/SLC8A1/KCNMA1/PIK3R5/CREB5/MEF2A/GNA13/INSR/NFATC2/AKT3/PDE3B/NFATC3",23]
["hsa04151","PI3K-Akt signaling pathway","38/432","354/8165",{"v":2.14153675992398e-05,"d":"2.14E-05"},0.000150405604999312,{"v":9.01699688389046e-05,"d":"9.02E-05"},"GNG7/BCL2/ITGA4/MAGI1/EFNA5/GNGT1/IGF1R/PIK3AP1/LPAR1/PIK3CD/SYK/GRB2/ITGA6/CREB3L2/COL1A1/COL1A2/FN1/FOXO3/SGK1/TLR2/CSF1R/PIK3R5/CREB5/GNB4/SPP1/JAK2/EGFR/INSR/PDGFC/PRKCA/IL7R/GNG2/PTK2/AKT3/PPP2R2B/CCND3/PPP2R5C/JAK1",38]
["hsa04810","Regulation of actin cytoskeleton","27/432","218/8165",{"v":2.96601628254611e-05,"d":"2.97E-05"},0.00020357657212021,0.000122046603013859,"ITGA4/DOCK1/NCKAP1L/VAV1/LPAR1/PIK3CD/ITGA6/PIP5K1B/PIP4K2A/FN1/ITGAX/IQGAP2/ITGAM/VAV3/TIAM1/ITGB2/ENAH/NCKAP1/EGFR/GSN/GNA13/PDGFC/ITGAL/PTK2/FGD3/ARHGEF1/CYFIP2",27]
["hsa04935","Growth hormone synthesis, secretion and action","18/432","120/8165",{"v":5.39670806620704e-05,"d":"5.40E-05"},0.000357722674269399,0.000214459044873951,"PLCG2/PRKCB/PLCB1/GNAQ/PIK3CD/ITPR2/GRB2/CREB3L2/MAP3K1/CACNA1C/ITPR1/CREB5/JAK2/STAT1/PRKCA/PTK2/AKT3/STAT5B",18]
["hsa04510","Focal adhesion","25/432","201/8165",{"v":5.44875596569283e-05,"d":"5.45E-05"},0.000357722674269399,0.000214459044873951,"PRKCB/BCL2/ITGA4/DOCK1/IGF1R/VAV1/PIK3CD/GRB2/RAPGEF1/ITGA6/PIP5K1B/COL1A1/COL1A2/FN1/PARVG/VAV3/SPP1/EGFR/PDGFC/PRKCA/FYN/PTK2/AKT3/CCND3/RAP1A",25]
["hsa05323","Rheumatoid arthritis","15/432","93/8165",{"v":9.70312867348567e-05,"d":"9.70E-05"},0.000623477629658015,0.000373782336358238,"HLA-DRA/HLA-DRB1/CD86/TLR2/HLA-DPB1/HLA-DPA1/HLA-DQB1/HLA-DMB/HLA-DQA1/IL18/ITGB2/CTSL/ATP6V1B2/TNFSF13B/ITGAL",15]
["hsa04929","GnRH secretion","12/432","64/8165",0.000110001992820401,0.000692095871495023,0.00041491979748046,"PRKCB/KCNN3/PLCB1/GNAQ/PIK3CD/ITPR2/CACNA1C/ITPR1/ARRB2/SPP1/PRKCA/AKT3",12]
["hsa05321","Inflammatory bowel disease","12/432","65/8165",0.000128573545975978,0.000792432875198886,0.000475073037763013,"HLA-DRA/HLA-DRB1/TLR2/HLA-DPB1/HLA-DPA1/HLA-DQB1/HLA-DMB/HLA-DQA1/IL18/STAT1/RORA/STAT4",12]
["hsa05165","Human papillomavirus infection","34/432","331/8165",0.000140975643453053,0.00085149288645644,0.000510480224714213,"ITGA4/MAGI1/PARD3/MAML3/TCF7L2/ATM/WNT5B/PIK3CD/TRAF3/GRB2/ITGA6/CREB3L2/COL1A1/DLG2/COL1A2/FN1/CREB5/PATJ/SPP1/ATP6V1B2/RBPJ/EGFR/STAT1/PTK2/HLA-B/AKT3/PPP2R2B/HLA-A/CCND3/HLA-C/PPP2R5C/JAK1/HLA-E/FOXO1",34]
["hsa04925","Aldosterone synthesis and secretion","15/432","98/8165",0.00017799136980968,0.00105398811142203,0.000631878547105572,"PRKCB/CAMK1D/PLCB1/ATP1B1/GNAQ/ITPR2/CREB3L2/CACNA1C/ATP2B1/ITPR1/CREB5/PRKD1/SCARB1/PRKCA/CAMK4",15]
["hsa04672","Intestinal immune network for IgA production","10/432","49/8165",0.000197747078018344,0.00114845418387577,0.000688512093505164,"ITGA4/HLA-DRA/HLA-DRB1/CD86/HLA-DPB1/HLA-DPA1/HLA-DQB1/HLA-DMB/HLA-DQA1/TNFSF13B",10]
["hsa05202","Transcriptional misregulation in cancer","23/432","193/8165",0.000206366202981109,0.00117589798679802,0.000704964983371414,"MEF2C/FUT8/PAX5/CDK14/FLI1/IGF1R/ATM/BMP2K/MITF/CD86/CSF1R/PLAU/SPI1/ITGAM/PBX3/ETV6/MLLT3/PBX1/PPARG/BCL11B/PTK2/ZEB1/FOXO1",23]
["hsa04730","Long-term depression","11/432","60/8165",0.000260695379732632,0.00145796304961583,0.00087406638039011,"PRKCB/PLCB1/IGF1R/PLA2G4A/GNAQ/ITPR2/ITPR1/PRKG1/LYN/GNA13/PRKCA",11]
["hsa05032","Morphine addiction","14/432","91/8165",0.000275290700183762,0.00151159620828175,0.000906220103954201,"GNG7/PRKCB/GNGT1/PDE10A/PDE4B/PDE4D/PDE7B/ARRB2/GNB4/GRK3/PRKCA/GNG2/PDE3B/PDE7A",14]
["hsa05161","Hepatitis B","20/432","162/8165",0.0003322462448868,0.00179175653492524,0.00107417958873176,"PRKCB/BCL2/PIK3CD/TRAF3/PTK2B/GRB2/CREB3L2/MAP3K1/CASP10/TLR2/CREB5/JAK2/STAT1/PRKCA/STAT4/NFATC2/AKT3/JAK1/STAT5B/NFATC3",20]
["hsa05223","Non-small cell lung cancer","12/432","72/8165",0.000350391841805855,0.00185646203904155,0.00111297131653937,"PLCG2/PRKCB/PIK3CD/GRB2/STK4/FOXO3/EGFR/EML4/PRKCA/FHIT/AKT3/STAT5B",12]
["hsa04371","Apelin signaling pathway","18/432","139/8165",0.000363757927277531,0.00189404989720369,0.00113550568950518,"GNG7/MEF2C/PLCB1/GNGT1/GNAQ/ITPR2/ITPR1/SLC8A1/PIK3R5/GNB4/SPP1/PRKAG2/MEF2A/GNA13/CAMK4/GNG2/AKT3/PDE3B",18]
["hsa04921","Oxytocin signaling pathway","19/432","154/8165",0.000469244080675264,0.00240189342989711,0.00143996399422204,"CD38/MEF2C/PRKCB/CAMK1D/PLCB1/PLA2G4A/GNAQ/PPP3CC/ITPR2/CACNA1C/ITPR1/TRPM2/PIK3R5/PRKAG2/EGFR/PRKCA/CAMK4/NFATC2/NFATC3",19]
["hsa04919","Thyroid hormone signaling pathway","16/432","121/8165",0.000603813055886846,0.00303919238129712,0.00182203237916732,"PLCG2/PRKCB/ATP2A3/PLCB1/ATP1B1/NCOA3/THRB/ESR1/PIK3CD/SLC16A10/HIF1A/STAT1/PRKCA/AKT3/KAT2B/FOXO1",16]
["hsa05146","Amoebiasis","14/432","102/8165",0.00090062619845208,0.00445883790053325,0.00267312693932283,"PRKCB/PLCB1/GNAQ/PIK3CD/COL1A1/COL1A2/FN1/COL3A1/TLR2/ITGAM/ITGB2/GNA14/PRKCA/PTK2",14]
["hsa05310","Asthma","7/432","31/8165",0.000959822565860711,0.00467526475628927,0.00280287744190225,"HLA-DRA/HLA-DRB1/HLA-DPB1/HLA-DPA1/HLA-DQB1/HLA-DMB/HLA-DQA1",7]
["hsa04064","NF-kappa B signaling pathway","14/432","104/8165",0.00109368865529753,0.00524276149047389,0.00314309855824855,"PLCG2/PRKCB/BCL2/BLNK/ATM/SYK/TRAF3/CARD11/PLAU/TNFSF13B/LYN/PRKCQ/LCK/CYLD",14]
["hsa04216","Ferroptosis","8/432","41/8165",0.00117425969213683,0.00554103792227065,0.00332191886591339,"SLC7A11/ACSL4/GCLC/CYBB/ATG7/TFRC/ACSL1/SAT1",8]
["hsa04926","Relaxin signaling pathway","16/432","129/8165",0.00121976916583986,0.00566723520128672,0.0033975756522179,"GNG7/PLCB1/GNGT1/PIK3CD/GRB2/CREB3L2/COL1A1/COL1A2/COL3A1/ARRB2/CREB5/GNB4/EGFR/PRKCA/GNG2/AKT3",16]
["hsa04071","Sphingolipid signaling pathway","15/432","119/8165",0.0014575089727668,0.00666920772387231,0.00399827022832359,"PRKCB/BCL2/PLCB1/GNAQ/PIK3CD/GAB2/SGPP2/CTSD/GNA13/CERS6/PRKCA/FYN/AKT3/PPP2R2B/PPP2R5C",15]
["hsa05150","Staphylococcus aureus infection","13/432","96/8165",0.00154321859274678,0.00695600022402279,0.0041702057808711,"HLA-DRA/HLA-DRB1/FPR3/HLA-DPB1/HLA-DPA1/FCGR2C/HLA-DQB1/HLA-DMB/HLA-DQA1/FCGR2A/ITGAM/ITGB2/ITGAL",13]
["hsa04012","ErbB signaling pathway","12/432","85/8165",0.00161066529865509,0.00715324882637995,0.00428845868991757,"PLCG2/PRKCB/PIK3CD/GRB2/GAB1/EGFR/PRKCA/PTK2/AKT3/CBLB/NCK2/STAT5B",12]
["hsa04144","Endocytosis","25/432","251/8165",0.00165165342717846,0.00722501090181209,0.00433148091708498,"PSD3/PARD3/IGF1R/AGAP1/SMAP2/NEDD4L/PIP5K1B/RAB31/DAB2/ARRB2/CYTH4/GRK3/TFRC/CYTH1/EGFR/ASAP1/ACAP1/HLA-B/SH3KBP1/HLA-A/ARAP2/HLA-C/CBLB/WIPF1/HLA-E",25]
["hsa04713","Circadian entrainment","13/432","97/8165",0.00169859527824059,0.00722501090181209,0.00433148091708498,"GNG7/PRKCB/PLCB1/GNGT1/GNAQ/GRIA4/RASD1/CACNA1C/ITPR1/PRKG1/GNB4/PRKCA/GNG2",13]
["hsa05215","Prostate cancer","13/432","97/8165",0.00169859527824059,0.00722501090181209,0.00433148091708498,"BCL2/IGF1R/TCF7L2/PIK3CD/GRB2/CREB3L2/PLAU/CREB5/EGFR/PDGFC/AKT3/ZEB1/FOXO1",13]
["hsa04927","Cortisol synthesis and secretion","10/432","65/8165",0.00202049377095791,0.00847484887262903,0.00508077381001113,"PLCB1/GNAQ/ITPR2/CREB3L2/CACNA1C/ITPR1/CREB5/SCARB1/PBX1/NCEH1",10]
["hsa04720","Long-term potentiation","10/432","67/8165",0.002547431275969,0.0104281996479489,0.00625183108904568,"PRKCB/PLCB1/GNAQ/PPP3CC/ITPR2/CACNA1C/ITPR1/PRKCA/CAMK4/RAP1A",10]
["hsa05203","Viral carcinogenesis","21/432","204/8165",0.00255525421837158,0.0104281996479489,0.00625183108904568,"HDAC9/PIK3CD/SYK/TRAF3/GRB2/CREB3L2/SP100/CREB5/RBPJ/GSN/LYN/VAC14/HLA-B/HLA-A/KAT2B/CCND3/HLA-C/JAK1/HLA-E/RASA2/STAT5B",21]
["hsa04960","Aldosterone-regulated sodium reabsorption","7/432","37/8165",0.00285640161905461,0.0114578823010363,0.00686913822160419,"PRKCB/ATP1B1/NEDD4L/PIK3CD/SGK1/INSR/PRKCA",7]
["hsa04726","Serotonergic synapse","14/432","115/8165",0.00288344057906874,0.0114578823010363,0.00686913822160419,"GNG7/PRKCB/PLCB1/GNGT1/MAOA/PLA2G4A/GNAQ/ITPR2/CACNA1C/ITPR1/ALOX5/GNB4/PRKCA/GNG2",14]
["hsa04970","Salivary secretion","12/432","92/8165",0.00318140606168282,0.0123440775226189,0.00740042291352542,"CD38/PRKCB/PLCB1/ATP1B1/GNAQ/ITPR2/ATP2B1/ITPR1/PRKG1/KCNMA1/LYZ/PRKCA",12]
["hsa04625","C-type lectin receptor signaling pathway","13/432","104/8165",0.00318820545286182,0.0123440775226189,0.00740042291352542,"PLCG2/PPP3CC/PIK3CD/SYK/ITPR2/ITPR1/CLEC7A/STAT1/NFATC2/AKT3/CBLB/CYLD/NFATC3",13]
["hsa04912","GnRH signaling pathway","12/432","93/8165",0.00348293607789212,0.0132525877175022,0.00794508570028015,"PRKCB/PLCB1/PLA2G4A/GNAQ/ITPR2/PTK2B/GRB2/MAP3K1/CACNA1C/ITPR1/EGFR/PRKCA",12]
["hsa04370","VEGF signaling pathway","9/432","59/8165",0.00354967919450119,0.0132525877175022,0.00794508570028015,"PLCG2/PRKCB/PLA2G4A/PPP3CC/PIK3CD/PRKCA/PTK2/NFATC2/AKT3",9]
["hsa04218","Cellular senescence","17/432","156/8165",0.00355450200370092,0.0132525877175022,0.00794508570028015,"ATM/PPP3CC/PIK3CD/ITPR2/ITPR1/FOXO3/ETS1/NFATC2/HLA-B/SQSTM1/AKT3/HLA-A/CCND3/HLA-C/HLA-E/FOXO1/NFATC3",17]
["hsa05130","Pathogenic Escherichia coli infection","20/432","197/8165",0.003758377368531,0.0138418288450776,0.00829834284194265,"NCKAP1L/CLDN10/LPAR1/MYO1D/SEC24A/MYO1F/MYO5A/FCGR2A/CYTH4/IL18/NCKAP1/MYO6/CYTH1/GNA13/MYO1E/FYN/ARHGEF1/WIPF1/NCK2/CYFIP2",20]
["hsa05164","Influenza A","18/432","171/8165",0.00398544380842461,0.0144539744449002,0.00866533149014579,"PRKCB/PIK3CD/TRAF3/CIITA/HLA-DRA/HLA-DRB1/HLA-DPB1/HLA-DPA1/HLA-DQB1/HLA-DMB/HLA-DQA1/IL18/JAK2/STAT1/PRKCA/AKT3/CCND3/JAK1",18]
["hsa04142","Lysosome","15/432","132/8165",0.00405118948430872,0.0144539744449002,0.00866533149014579,"CTSB/DMXL2/SLC11A1/CTSZ/LAPTM5/PSAP/LITAF/CTSL/MANBA/CTSC/CTSD/ARSB/CTSS/LGMN/NPC1",15]
["hsa04020","Calcium signaling pathway","23/432","240/8165",0.00406817161528647,0.0144539744449002,0.00866533149014579,"PLCG2/CD38/PRKCB/CAMK1D/ATP2A3/PLCB1/GNAQ/PPP3CC/ITPR2/PTK2B/CACNA1C/ATP2B1/ITPR1/SLC8A1/P2RX7/GNA14/EGFR/PDGFC/PRKCA/CAMK4/ASPH/ITPKB/STIM1",23]
["hsa04931","Insulin resistance","13/432","108/8165",0.00443294802585319,0.0155668639977635,0.00933252215969092,"PRKCB/CD36/OGT/PIK3CD/CREB3L2/PTPN1/CREB5/PRKAG2/NR1H3/INSR/PRKCQ/AKT3/FOXO1",13]
["hsa04270","Vascular smooth muscle contraction","15/432","134/8165",0.00466981527120678,0.0162101633552235,0.00971818786022464,"PRKCB/PLCB1/PLA2G4A/GNAQ/ITPR2/CACNA1C/CALD1/ITPR1/PRKG1/KCNMA1/GNA13/PRKCA/PRKCH/PRKCQ/ARHGEF1",15]
["hsa04066","HIF-1 signaling pathway","13/432","109/8165",0.00479854066234137,0.016467719091217,0.00987259562108511,"PLCG2/PRKCB/BCL2/PDK1/IGF1R/PIK3CD/CYBB/TFRC/EGFR/HIF1A/INSR/PRKCA/AKT3",13]
["hsa04070","Phosphatidylinositol signaling system","12/432","97/8165",0.00492778849762973,0.0167212598458897,0.0100245963523633,"PLCG2/PRKCB/INPP5D/PLCB1/PIK3CD/ITPR2/PIP5K1B/PIP4K2A/ITPR1/INPP4B/PRKCA/ITPKB",12]
["hsa04613","Neutrophil extracellular trap formation","19/432","190/8165",0.005508075143672,0.018482652148766,0.0110805722188489,"PLCG2/PRKCB/HDAC9/PLCB1/PIK3CD/SYK/TLR2/FPR3/CLEC7A/CYBB/FCGR2A/ITGAM/ATG7/NCF2/ITGB2/MACROH2A1/PRKCA/ITGAL/AKT3",19]
["hsa05131","Shigellosis","23/432","247/8165",0.00577585078401222,0.0191682080963922,0.0114915712533268,"PLCG2/BCL2/SEPTIN6/DOCK1/PLCB1/ELMO1/ATM/FNBP1L/PIK3CD/FNBP1/ITPR2/ITPR1/FOXO3/CYTH4/IL18/CYTH1/EGFR/PRKCQ/PTK2/SQSTM1/AKT3/CD44/FOXO1",23]
["hsa05214","Glioma","10/432","75/8165",0.00584770033169866,0.0191957119584021,0.0115080601493383,"PLCG2/PRKCB/CAMK1D/IGF1R/PIK3CD/GRB2/EGFR/PRKCA/CAMK4/AKT3",10]
["hsa04915","Estrogen signaling pathway","15/432","138/8165",0.00613759187370935,0.0199306746866691,0.0119486791429316,"BCL2/PLCB1/NCOA3/GNAQ/ESR1/PIK3CD/ITPR2/GRB2/CREB3L2/ITPR1/CREB5/CTSD/EGFR/AKT3/FKBP5",15]
["hsa04961","Endocrine and other factor-regulated calcium reabsorption","8/432","53/8165",0.00625801820209803,0.020105547840783,0.0120535177016894,"PRKCB/PLCB1/ATP1B1/GNAQ/ESR1/ATP2B1/SLC8A1/PRKCA",8]
["hsa04540","Gap junction","11/432","88/8165",0.00644396830577296,0.0204850360878256,0.012281025469174,"PRKCB/PLCB1/GNAQ/LPAR1/ITPR2/GRB2/ITPR1/PRKG1/EGFR/PDGFC/PRKCA",11]
["hsa04211","Longevity regulating pathway","11/432","89/8165",0.00701410458134631,0.0220652039954853,0.0132283551314865,"IGF1R/PIK3CD/CREB3L2/FOXO3/CREB5/PRKAG2/INSR/PPARG/CAMK4/AKT3/FOXO1",11]
["hsa04972","Pancreatic secretion","12/432","102/8165",0.00736647838321327,0.0229348089869114,0.0137496937809298,"CD38/PRKCB/ATP2A3/PLCB1/ATP1B1/GNAQ/ITPR2/ATP2B1/ITPR1/KCNMA1/PRKCA/RAP1A",12]
["hsa04140","Autophagy - animal","15/432","141/8165",0.00746571097062234,0.0230065787053872,0.0137927205901938,"BCL2/VMP1/IGF1R/DAPK1/PIK3CD/EIF2AK3/ITPR1/CTSB/ATG7/CTSL/CTSD/HIF1A/PRKCQ/SQSTM1/AKT3",15]
["hsa04360","Axon guidance","18/432","182/8165",0.00760940593451263,0.0232125312345739,0.0139161916080401,"DCC/PLCG2/EFNA5/PARD3/WNT5B/PPP3CC/PIK3CD/SEMA4D/PLXNC1/NRP1/ENAH/ABLIM1/PRKCA/FYN/PTK2/NFATC2/NCK2/NFATC3",18]
["hsa05221","Acute myeloid leukemia","9/432","67/8165",0.0083272584195355,0.0251483204269972,0.0150767205069485,"TCF7L2/PIK3CD/GRB2/CSF1R/SPI1/ITGAM/PPARD/AKT3/STAT5B",9]
["hsa04722","Neurotrophin signaling pathway","13/432","119/8165",0.00995280230426895,0.0294975665675558,0.0176841458683151,"PLCG2/BCL2/IRAK3/PIK3CD/GRB2/RAPGEF1/MAP3K1/GAB1/FOXO3/SH2B3/CAMK4/AKT3/RAP1A",13]
["hsa04924","Renin secretion","9/432","69/8165",0.0100604283326432,0.0294975665675558,0.0176841458683151,"PLCB1/GNAQ/PPP3CC/ITPR2/CACNA1C/ITPR1/KCNMA1/CTSB/PDE3B",9]
["hsa05031","Amphetamine addiction","9/432","69/8165",0.0100604283326432,0.0294975665675558,0.0176841458683151,"PRKCB/MAOA/GRIA4/PPP3CC/CREB3L2/CACNA1C/CREB5/PRKCA/CAMK4",9]
["hsa04152","AMPK signaling pathway","13/432","121/8165",0.0113716034957303,0.03302138707414,0.0197967186362916,"IGF1R/CD36/PIK3CD/CREB3L2/FOXO3/CREB5/PRKAG2/INSR/PPARG/AKT3/PPP2R2B/PPP2R5C/FOXO1",13]
["hsa04520","Adherens junction","9/432","71/8165",0.0120522615768367,0.0346645999638543,0.0207818445234679,"PTPRM/PARD3/IGF1R/TCF7L2/PTPN1/PTPRJ/EGFR/INSR/FYN",9]
["hsa04010","MAPK signaling pathway","25/432","294/8165",0.0125761542729628,0.0355579116236509,0.0213173956056743,"MEF2C/PRKCB/RASGRP3/MECOM/EFNA5/IGF1R/PLA2G4A/PPP3CC/GRB2/MAP3K1/CACNA1C/STK4/CSF1R/ARRB2/EGFR/INSR/PDGFC/PRKCA/STK3/AKT3/RASGRP1/RAP1A/RASA2/DUSP16/NFATC3",25]
["hsa04210","Apoptosis","14/432","136/8165",0.0125983329262604,0.0355579116236509,0.0213173956056743,"BCL2/ATM/PIK3CD/ITPR2/EIF2AK3/CASP10/ITPR1/CTSB/CTSZ/CTSL/CTSC/CTSD/CTSS/AKT3",14]
["hsa04261","Adrenergic signaling in cardiomyocytes","15/432","150/8165",0.0128698417023023,0.0359878906860677,0.0215751732241326,"BCL2/ATP2A3/PLCB1/ATP1B1/GNAQ/CREB3L2/CACNA1C/ATP2B1/SLC8A1/PIK3R5/CREB5/PRKCA/AKT3/PPP2R2B/PPP2R5C",15]
["hsa05340","Primary immunodeficiency","6/432","38/8165",0.0138440041304146,0.0383463186703378,0.0229890791610251,"PTPRC/BLNK/CIITA/CD4/IL7R/LCK",6]
["hsa04750","Inflammatory mediator regulation of TRP channels","11/432","98/8165",0.0140941767298262,0.0383463186703378,0.0229890791610251,"PLCG2/PRKCB/PLCB1/PLA2G4A/GNAQ/PIK3CD/ITPR2/ITPR1/PRKCA/PRKCH/PRKCQ",11]
["hsa05231","Choline metabolism in cancer","11/432","98/8165",0.0140941767298262,0.0383463186703378,0.0229890791610251,"PRKCB/PLA2G4A/SLC44A5/PIK3CD/GRB2/PIP5K1B/EGFR/HIF1A/PDGFC/PRKCA/AKT3",11]
["hsa00562","Inositol phosphate metabolism","9/432","73/8165",0.014324490540609,0.0386249655648564,0.0231561313250446,"PLCG2/INPP5D/PLCB1/PLCH1/PIK3CD/PIP5K1B/PIP4K2A/INPP4B/ITPKB",9]
["hsa04911","Insulin secretion","10/432","86/8165",0.0149431995881273,0.0399366927045525,0.023942527518937,"PRKCB/KCNN3/PLCB1/ATP1B1/GNAQ/CREB3L2/CACNA1C/KCNMA1/CREB5/PRKCA",10]
["hsa03320","PPAR signaling pathway","9/432","75/8165",0.016898585343687,0.043602982353663,0.0261405122510632,"CD36/ME1/ACSL4/CYP27A1/NR1H3/PPARD/ACSL1/GK/PPARG",9]
["hsa04918","Thyroid hormone synthesis","9/432","75/8165",0.016898585343687,0.043602982353663,0.0261405122510632,"PRKCB/PLCB1/ATP1B1/GNAQ/ITPR2/CREB3L2/ITPR1/CREB5/PRKCA",9]
["hsa04934","Cushing syndrome","15/432","155/8165",0.0169752017566307,0.043602982353663,0.0261405122510632,"PLCB1/TCF7L2/GNAQ/WNT5B/ITPR2/RASD1/CREB3L2/CACNA1C/ITPR1/CREB5/EGFR/SCARB1/PBX1/NCEH1/RAP1A",15]
["hsa04913","Ovarian steroidogenesis","7/432","51/8165",0.0170369268799081,0.043602982353663,0.0261405122510632,"AKR1C3/IGF1R/PLA2G4A/BMP6/ALOX5/SCARB1/INSR",7]
["hsa04979","Cholesterol metabolism","7/432","51/8165",0.0170369268799081,0.043602982353663,0.0261405122510632,"CD36/ABCA1/APOE/CYP27A1/SCARB1/NCEH1/NPC1",7]
["hsa04727","GABAergic synapse","10/432","89/8165",0.0186654032155396,0.0473693426142266,0.0283984905181142,"GNG7/PRKCB/GNGT1/CACNA1C/GNB4/PLCL1/GLUL/PRKCA/GNG2/SLC38A1",10]
["hsa04068","FoxO signaling pathway","13/432","131/8165",0.020949730091711,0.0527234873974726,0.0316083646997744,"IGF1R/ATM/PIK3CD/GRB2/STK4/FOXO3/SGK1/PRKAG2/EGFR/INSR/IL7R/AKT3/FOXO1",13]
["hsa04630","JAK-STAT signaling pathway","15/432","162/8165",0.0243255527977956,0.0607133631812749,0.036398391311186,"BCL2/PIK3CD/GRB2/CSF2RA/IL10RA/JAK2/EGFR/PIAS1/STAT1/STAT4/IL7R/AKT3/CCND3/JAK1/STAT5B",15]
["hsa04922","Glucagon signaling pathway","11/432","107/8165",0.0255820108641379,0.0633259613194234,0.0379646753117491,"PLCB1/GNAQ/PPP3CC/ITPR2/CREB3L2/ITPR1/CREB5/PRKAG2/AKT3/PDE3B/FOXO1",11]
["hsa04920","Adipocytokine signaling pathway","8/432","69/8165",0.0284334198696809,0.0692491354890615,0.0415156894531843,"CD36/ACSL4/TNFRSF1B/JAK2/PRKAG2/ACSL1/PRKCQ/AKT3",8]
["hsa05211","Renal cell carcinoma","8/432","69/8165",0.0284334198696809,0.0692491354890615,0.0415156894531843,"PIK3CD/GRB2/RAPGEF1/GAB1/HIF1A/ETS1/AKT3/RAP1A",8]
["hsa04917","Prolactin signaling pathway","8/432","70/8165",0.0306799707920344,0.0741228094335552,0.0444375155893046,"ESR1/PIK3CD/GRB2/FOXO3/JAK2/STAT1/AKT3/STAT5B",8]