Drug pairs with common pharmacological targets that reduce the overall side effect of 50% for both drugs Drug1 : DB00001 Lepirudin Drug2 : DB00006 Bivalirudin Pharmacological target (-,-) : BE0000048 Prothrombin --------------------------------------------------- Drug1 : DB00001 Lepirudin Drug2 : DB00278 Argatroban Pharmacological target (-,-) : BE0000048 Prothrombin --------------------------------------------------- Drug1 : DB00001 Lepirudin Drug2 : DB04898 Ximelagatran Pharmacological target (-,-) : BE0000048 Prothrombin --------------------------------------------------- Drug1 : DB00001 Lepirudin Drug2 : DB06695 Dabigatran etexilate Pharmacological target (-,-) : BE0000048 Prothrombin --------------------------------------------------- Drug1 : DB00002 Cetuximab Drug2 : DB00317 Gefitinib Pharmacological target (-,-) : BE0000767 Epidermal growth factor receptor --------------------------------------------------- Drug1 : DB00002 Cetuximab Drug2 : DB00530 Erlotinib Pharmacological target (-,-) : BE0000767 Epidermal growth factor receptor Non-common off-target(s) (drug2) : BE0000956 Nuclear receptor subfamily 1 group I member 2 (1) --------------------------------------------------- Drug1 : DB00002 Cetuximab Drug2 : DB01259 Lapatinib Pharmacological target (-,-) : BE0000767 Epidermal growth factor receptor Non-common off-target(s) (drug2) : BE0000511 Receptor tyrosine-protein kinase erbB-2 (-1) --------------------------------------------------- Drug1 : DB00002 Cetuximab Drug2 : DB01269 Panitumumab Pharmacological target (-,-) : BE0000767 Epidermal growth factor receptor --------------------------------------------------- Drug1 : DB00006 Bivalirudin Drug2 : DB00278 Argatroban Pharmacological target (-,-) : BE0000048 Prothrombin --------------------------------------------------- Drug1 : DB00006 Bivalirudin Drug2 : DB04898 Ximelagatran Pharmacological target (-,-) : BE0000048 Prothrombin --------------------------------------------------- Drug1 : DB00006 Bivalirudin Drug2 : DB06695 Dabigatran etexilate Pharmacological target (-,-) : BE0000048 Prothrombin --------------------------------------------------- Drug1 : DB00007 Leuprolide Drug2 : DB00014 Goserelin Pharmacological target (+,+) : BE0000203 Gonadotropin-releasing hormone receptor Non-common off-target(s) (drug2) : BE0000134 Lutropin-choriogonadotropic hormone receptor (1) --------------------------------------------------- Drug1 : DB00007 Leuprolide Drug2 : DB00644 Gonadorelin Pharmacological target (+,+) : BE0000203 Gonadotropin-releasing hormone receptor Non-common off-target(s) (drug2) : BE0000472 Putative gonadotropin-releasing hormone II receptor (1) --------------------------------------------------- Drug1 : DB00007 Leuprolide Drug2 : DB00666 Nafarelin Pharmacological target (+,+) : BE0000203 Gonadotropin-releasing hormone receptor Non-common off-target(s) (drug2) : BE0000472 Putative gonadotropin-releasing hormone II receptor (1) --------------------------------------------------- Drug1 : DB00008 Peginterferon alfa-2a Drug2 : DB00011 Interferon alfa-n1 Pharmacological target (+,+) : BE0000385 Interferon alpha/beta receptor 2 Pharmacological target (+,+) : BE0000661 Interferon alpha/beta receptor 1 --------------------------------------------------- Drug1 : DB00008 Peginterferon alfa-2a Drug2 : DB00018 Interferon alfa-n3 Pharmacological target (+,+) : BE0000385 Interferon alpha/beta receptor 2 Pharmacological target (+,+) : BE0000661 Interferon alpha/beta receptor 1 --------------------------------------------------- Drug1 : DB00008 Peginterferon alfa-2a Drug2 : DB00022 Peginterferon alfa-2b Pharmacological target (+,+) : BE0000385 Interferon alpha/beta receptor 2 Pharmacological target (+,+) : BE0000661 Interferon alpha/beta receptor 1 --------------------------------------------------- Drug1 : DB00008 Peginterferon alfa-2a Drug2 : DB00060 Interferon beta-1a Pharmacological target (+,+) : BE0000661 Interferon alpha/beta receptor 1 Non-common off-target(s) (drug1) : BE0000385 Interferon alpha/beta receptor 2 (1) --------------------------------------------------- Drug1 : DB00008 Peginterferon alfa-2a Drug2 : DB00068 Interferon beta-1b Pharmacological target (+,+) : BE0000385 Interferon alpha/beta receptor 2 Pharmacological target (+,+) : BE0000661 Interferon alpha/beta receptor 1 --------------------------------------------------- Drug1 : DB00009 Alteplase Drug2 : DB00013 Urokinase Pharmacological target (+,+) : BE0000211 Plasminogen --------------------------------------------------- Drug1 : DB00009 Alteplase Drug2 : DB00015 Reteplase Pharmacological target (+,+) : BE0000211 Plasminogen --------------------------------------------------- Drug1 : DB00009 Alteplase Drug2 : DB00029 Anistreplase Pharmacological target (+,+) : BE0000211 Plasminogen --------------------------------------------------- Drug1 : DB00009 Alteplase Drug2 : DB00031 Tenecteplase Pharmacological target (+,+) : BE0000211 Plasminogen --------------------------------------------------- Drug1 : DB00009 Alteplase Drug2 : DB00086 Streptokinase Pharmacological target (+,+) : BE0000211 Plasminogen --------------------------------------------------- Drug1 : DB00011 Interferon alfa-n1 Drug2 : DB00018 Interferon alfa-n3 Pharmacological target (+,+) : BE0000385 Interferon alpha/beta receptor 2 Pharmacological target (+,+) : BE0000661 Interferon alpha/beta receptor 1 --------------------------------------------------- Drug1 : DB00011 Interferon alfa-n1 Drug2 : DB00022 Peginterferon alfa-2b Pharmacological target (+,+) : BE0000385 Interferon alpha/beta receptor 2 Pharmacological target (+,+) : BE0000661 Interferon alpha/beta receptor 1 --------------------------------------------------- Drug1 : DB00011 Interferon alfa-n1 Drug2 : DB00060 Interferon beta-1a Pharmacological target (+,+) : BE0000661 Interferon alpha/beta receptor 1 Non-common off-target(s) (drug1) : BE0000385 Interferon alpha/beta receptor 2 (1) --------------------------------------------------- Drug1 : DB00011 Interferon alfa-n1 Drug2 : DB00068 Interferon beta-1b Pharmacological target (+,+) : BE0000385 Interferon alpha/beta receptor 2 Pharmacological target (+,+) : BE0000661 Interferon alpha/beta receptor 1 --------------------------------------------------- Drug1 : DB00012 Darbepoetin alfa Drug2 : DB00016 Epoetin alfa Pharmacological target (+,+) : BE0000654 Erythropoietin receptor --------------------------------------------------- Drug1 : DB00012 Darbepoetin alfa Drug2 : DB08894 Peginesatide Pharmacological target (+,+) : BE0000654 Erythropoietin receptor --------------------------------------------------- Drug1 : DB00012 Darbepoetin alfa Drug2 : DB08923 Epoetin Zeta Pharmacological target (+,+) : BE0000654 Erythropoietin receptor --------------------------------------------------- Drug1 : DB00013 Urokinase Drug2 : DB00015 Reteplase Pharmacological target (+,+) : BE0000211 Plasminogen --------------------------------------------------- Drug1 : DB00013 Urokinase Drug2 : DB00029 Anistreplase Pharmacological target (+,+) : BE0000211 Plasminogen --------------------------------------------------- Drug1 : DB00013 Urokinase Drug2 : DB00031 Tenecteplase Pharmacological target (+,+) : BE0000211 Plasminogen --------------------------------------------------- Drug1 : DB00013 Urokinase Drug2 : DB00086 Streptokinase Pharmacological target (+,+) : BE0000211 Plasminogen --------------------------------------------------- Drug1 : DB00014 Goserelin Drug2 : DB00044 Lutropin alfa Pharmacological target (+,+) : BE0000134 Lutropin-choriogonadotropic hormone receptor Non-common off-target(s) (drug1) : BE0000203 Gonadotropin-releasing hormone receptor (1) --------------------------------------------------- Drug1 : DB00014 Goserelin Drug2 : DB00644 Gonadorelin Pharmacological target (+,+) : BE0000203 Gonadotropin-releasing hormone receptor Non-common off-target(s) (drug1) : BE0000134 Lutropin-choriogonadotropic hormone receptor (1) Non-common off-target(s) (drug2) : BE0000472 Putative gonadotropin-releasing hormone II receptor (1) --------------------------------------------------- Drug1 : DB00014 Goserelin Drug2 : DB00666 Nafarelin Pharmacological target (+,+) : BE0000203 Gonadotropin-releasing hormone receptor Non-common off-target(s) (drug1) : BE0000134 Lutropin-choriogonadotropic hormone receptor (1) Non-common off-target(s) (drug2) : BE0000472 Putative gonadotropin-releasing hormone II receptor (1) --------------------------------------------------- Drug1 : DB00015 Reteplase Drug2 : DB00029 Anistreplase Pharmacological target (+,+) : BE0000211 Plasminogen --------------------------------------------------- Drug1 : DB00015 Reteplase Drug2 : DB00031 Tenecteplase Pharmacological target (+,+) : BE0000211 Plasminogen --------------------------------------------------- Drug1 : DB00015 Reteplase Drug2 : DB00086 Streptokinase Pharmacological target (+,+) : BE0000211 Plasminogen --------------------------------------------------- Drug1 : DB00016 Epoetin alfa Drug2 : DB08894 Peginesatide Pharmacological target (+,+) : BE0000654 Erythropoietin receptor --------------------------------------------------- Drug1 : DB00016 Epoetin alfa Drug2 : DB08923 Epoetin Zeta Pharmacological target (+,+) : BE0000654 Erythropoietin receptor --------------------------------------------------- Drug1 : DB00018 Interferon alfa-n3 Drug2 : DB00022 Peginterferon alfa-2b Pharmacological target (+,+) : BE0000385 Interferon alpha/beta receptor 2 Pharmacological target (+,+) : BE0000661 Interferon alpha/beta receptor 1 --------------------------------------------------- Drug1 : DB00018 Interferon alfa-n3 Drug2 : DB00060 Interferon beta-1a Pharmacological target (+,+) : BE0000661 Interferon alpha/beta receptor 1 Non-common off-target(s) (drug1) : BE0000385 Interferon alpha/beta receptor 2 (1) --------------------------------------------------- Drug1 : DB00018 Interferon alfa-n3 Drug2 : DB00068 Interferon beta-1b Pharmacological target (+,+) : BE0000385 Interferon alpha/beta receptor 2 Pharmacological target (+,+) : BE0000661 Interferon alpha/beta receptor 1 --------------------------------------------------- Drug1 : DB00019 Pegfilgrastim Drug2 : DB00099 Filgrastim Pharmacological target (+,+) : BE0000793 Granulocyte colony-stimulating factor receptor --------------------------------------------------- Drug1 : DB00022 Peginterferon alfa-2b Drug2 : DB00060 Interferon beta-1a Pharmacological target (+,+) : BE0000661 Interferon alpha/beta receptor 1 Non-common off-target(s) (drug1) : BE0000385 Interferon alpha/beta receptor 2 (1) --------------------------------------------------- Drug1 : DB00022 Peginterferon alfa-2b Drug2 : DB00068 Interferon beta-1b Pharmacological target (+,+) : BE0000385 Interferon alpha/beta receptor 2 Pharmacological target (+,+) : BE0000661 Interferon alpha/beta receptor 1 --------------------------------------------------- Drug1 : DB00025 Antihemophilic Factor Drug2 : DB00100 Coagulation Factor IX Pharmacological target (+,+) : BE0000216 Coagulation factor X Non-common off-target(s) (drug1) : BE0002117 Phytanoyl-CoA dioxygenase, peroxisomal (-1) --------------------------------------------------- Drug1 : DB00029 Anistreplase Drug2 : DB00031 Tenecteplase Pharmacological target (+,+) : BE0000211 Plasminogen --------------------------------------------------- Drug1 : DB00029 Anistreplase Drug2 : DB00086 Streptokinase Pharmacological target (+,+) : BE0000211 Plasminogen --------------------------------------------------- Drug1 : DB00030 Insulin Regular Drug2 : DB00046 Insulin Lispro Pharmacological target (+,+) : BE0000033 Insulin receptor --------------------------------------------------- Drug1 : DB00030 Insulin Regular Drug2 : DB00047 Insulin Glargine Pharmacological target (+,+) : BE0000033 Insulin receptor Non-common off-target(s) (drug2) : BE0000858 Insulin-like growth factor 1 receptor (1) --------------------------------------------------- Drug1 : DB00030 Insulin Regular Drug2 : DB01306 Insulin Aspart Pharmacological target (+,+) : BE0000033 Insulin receptor --------------------------------------------------- Drug1 : DB00030 Insulin Regular Drug2 : DB01307 Insulin Detemir Pharmacological target (+,+) : BE0000033 Insulin receptor --------------------------------------------------- Drug1 : DB00030 Insulin Regular Drug2 : DB01309 Insulin Glulisine Pharmacological target (+,+) : BE0000033 Insulin receptor --------------------------------------------------- Drug1 : DB00030 Insulin Regular Drug2 : DB08914 Insulin, isophane Pharmacological target (+,+) : BE0000033 Insulin receptor --------------------------------------------------- Drug1 : DB00031 Tenecteplase Drug2 : DB00086 Streptokinase Pharmacological target (+,+) : BE0000211 Plasminogen --------------------------------------------------- Drug1 : DB00035 Desmopressin Drug2 : DB00067 Vasopressin Pharmacological target (+,+) : BE0000293 Vasopressin V2 receptor --------------------------------------------------- Drug1 : DB00035 Desmopressin Drug2 : DB02638 Terlipressin Pharmacological target (+,+) : BE0000293 Vasopressin V2 receptor Non-common off-target(s) (drug2) : BE0000165 Vasopressin V1a receptor (1) --------------------------------------------------- Drug1 : DB00046 Insulin Lispro Drug2 : DB00047 Insulin Glargine Pharmacological target (+,+) : BE0000033 Insulin receptor Non-common off-target(s) (drug2) : BE0000858 Insulin-like growth factor 1 receptor (1) --------------------------------------------------- Drug1 : DB00046 Insulin Lispro Drug2 : DB01306 Insulin Aspart Pharmacological target (+,+) : BE0000033 Insulin receptor --------------------------------------------------- Drug1 : DB00046 Insulin Lispro Drug2 : DB01307 Insulin Detemir Pharmacological target (+,+) : BE0000033 Insulin receptor --------------------------------------------------- Drug1 : DB00046 Insulin Lispro Drug2 : DB01309 Insulin Glulisine Pharmacological target (+,+) : BE0000033 Insulin receptor --------------------------------------------------- Drug1 : DB00046 Insulin Lispro Drug2 : DB08914 Insulin, isophane Pharmacological target (+,+) : BE0000033 Insulin receptor --------------------------------------------------- Drug1 : DB00047 Insulin Glargine Drug2 : DB01306 Insulin Aspart Pharmacological target (+,+) : BE0000033 Insulin receptor Non-common off-target(s) (drug1) : BE0000858 Insulin-like growth factor 1 receptor (1) --------------------------------------------------- Drug1 : DB00047 Insulin Glargine Drug2 : DB01307 Insulin Detemir Pharmacological target (+,+) : BE0000033 Insulin receptor Non-common off-target(s) (drug1) : BE0000858 Insulin-like growth factor 1 receptor (1) --------------------------------------------------- Drug1 : DB00047 Insulin Glargine Drug2 : DB01309 Insulin Glulisine Pharmacological target (+,+) : BE0000033 Insulin receptor Non-common off-target(s) (drug1) : BE0000858 Insulin-like growth factor 1 receptor (1) --------------------------------------------------- Drug1 : DB00047 Insulin Glargine Drug2 : DB08914 Insulin, isophane Pharmacological target (+,+) : BE0000033 Insulin receptor Non-common off-target(s) (drug1) : BE0000858 Insulin-like growth factor 1 receptor (1) --------------------------------------------------- Drug1 : DB00050 Cetrorelix Drug2 : DB00106 Abarelix Pharmacological target (-,-) : BE0000203 Gonadotropin-releasing hormone receptor --------------------------------------------------- Drug1 : DB00050 Cetrorelix Drug2 : DB06699 Degarelix Pharmacological target (-,-) : BE0000203 Gonadotropin-releasing hormone receptor --------------------------------------------------- Drug1 : DB00054 Abciximab Drug2 : DB00775 Tirofiban Pharmacological target (-,-) : BE0001155 Integrin beta-3 Pharmacological target (-,-) : BE0000439 Integrin alpha-IIb --------------------------------------------------- Drug1 : DB00060 Interferon beta-1a Drug2 : DB00068 Interferon beta-1b Pharmacological target (+,+) : BE0000661 Interferon alpha/beta receptor 1 Non-common off-target(s) (drug2) : BE0000385 Interferon alpha/beta receptor 2 (1) --------------------------------------------------- Drug1 : DB00065 Infliximab Drug2 : DB08904 Certolizumab pegol Pharmacological target (-,-) : BE0000704 Tumor necrosis factor --------------------------------------------------- Drug1 : DB00066 Follitropin beta Drug2 : DB00094 Urofollitropin Pharmacological target (+,+) : BE0000387 Follicle-stimulating hormone receptor --------------------------------------------------- Drug1 : DB00067 Vasopressin Drug2 : DB02638 Terlipressin Pharmacological target (+,+) : BE0000293 Vasopressin V2 receptor Non-common off-target(s) (drug2) : BE0000165 Vasopressin V1a receptor (1) --------------------------------------------------- Drug1 : DB00106 Abarelix Drug2 : DB06699 Degarelix Pharmacological target (-,-) : BE0000203 Gonadotropin-releasing hormone receptor --------------------------------------------------- Drug1 : DB00107 Oxytocin Drug2 : DB01282 Carbetocin Pharmacological target (+,+) : BE0000844 Oxytocin receptor --------------------------------------------------- Drug1 : DB00146 Calcidiol Drug2 : DB00153 Ergocalciferol Pharmacological target (+,+) : BE0000779 Vitamin D3 receptor --------------------------------------------------- Drug1 : DB00146 Calcidiol Drug2 : DB00169 Cholecalciferol Pharmacological target (+,+) : BE0000779 Vitamin D3 receptor --------------------------------------------------- Drug1 : DB00146 Calcidiol Drug2 : DB00910 Paricalcitol Pharmacological target (+,+) : BE0000779 Vitamin D3 receptor --------------------------------------------------- Drug1 : DB00146 Calcidiol Drug2 : DB01070 Dihydrotachysterol Pharmacological target (+,+) : BE0000779 Vitamin D3 receptor --------------------------------------------------- Drug1 : DB00146 Calcidiol Drug2 : DB01436 Alfacalcidol Pharmacological target (+,+) : BE0000779 Vitamin D3 receptor --------------------------------------------------- Drug1 : DB00153 Ergocalciferol Drug2 : DB00169 Cholecalciferol Pharmacological target (+,+) : BE0000779 Vitamin D3 receptor --------------------------------------------------- Drug1 : DB00153 Ergocalciferol Drug2 : DB00910 Paricalcitol Pharmacological target (+,+) : BE0000779 Vitamin D3 receptor --------------------------------------------------- Drug1 : DB00153 Ergocalciferol Drug2 : DB01070 Dihydrotachysterol Pharmacological target (+,+) : BE0000779 Vitamin D3 receptor --------------------------------------------------- Drug1 : DB00153 Ergocalciferol Drug2 : DB01436 Alfacalcidol Pharmacological target (+,+) : BE0000779 Vitamin D3 receptor --------------------------------------------------- Drug1 : DB00154 Dihomo-gamma-linolenic acid Drug2 : DB00316 Acetaminophen Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Non-common off-target(s) (drug2) : BE0000262 Prostaglandin G/H synthase 2 (-1) --------------------------------------------------- Drug1 : DB00154 Dihomo-gamma-linolenic acid Drug2 : DB00788 Naproxen Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Non-common off-target(s) (drug2) : BE0000262 Prostaglandin G/H synthase 2 (-1) --------------------------------------------------- Drug1 : DB00154 Dihomo-gamma-linolenic acid Drug2 : DB00870 Suprofen Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Non-common off-target(s) (drug2) : BE0000262 Prostaglandin G/H synthase 2 (-1) --------------------------------------------------- Drug1 : DB00154 Dihomo-gamma-linolenic acid Drug2 : DB00936 Salicylic acid Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Non-common off-target(s) (drug2) : BE0000262 Prostaglandin G/H synthase 2 (-1) BE0000126 Aldo-keto reductase family 1 member C1 (-1) --------------------------------------------------- Drug1 : DB00154 Dihomo-gamma-linolenic acid Drug2 : DB00945 Acetylsalicylic acid Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Non-common off-target(s) (drug2) : BE0000262 Prostaglandin G/H synthase 2 (-1) BE0000126 Aldo-keto reductase family 1 member C1 (-1) BE0004907 5'-AMP-activated protein kinase (1) BE0004903 Nuclear factor NF-kappa-B (-1) --------------------------------------------------- Drug1 : DB00154 Dihomo-gamma-linolenic acid Drug2 : DB00991 Oxaprozin Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Non-common off-target(s) (drug2) : BE0000262 Prostaglandin G/H synthase 2 (-1) --------------------------------------------------- Drug1 : DB00154 Dihomo-gamma-linolenic acid Drug2 : DB01283 Lumiracoxib Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Non-common off-target(s) (drug2) : BE0000262 Prostaglandin G/H synthase 2 (-1) --------------------------------------------------- Drug1 : DB00154 Dihomo-gamma-linolenic acid Drug2 : DB01397 Magnesium salicylate Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Non-common off-target(s) (drug2) : BE0000262 Prostaglandin G/H synthase 2 (-1) --------------------------------------------------- Drug1 : DB00154 Dihomo-gamma-linolenic acid Drug2 : DB01398 Salicylate-sodium Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Non-common off-target(s) (drug2) : BE0000262 Prostaglandin G/H synthase 2 (-1) --------------------------------------------------- Drug1 : DB00154 Dihomo-gamma-linolenic acid Drug2 : DB01399 Salsalate Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Non-common off-target(s) (drug2) : BE0000262 Prostaglandin G/H synthase 2 (-1) --------------------------------------------------- Drug1 : DB00154 Dihomo-gamma-linolenic acid Drug2 : DB01600 Tiaprofenic acid Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Non-common off-target(s) (drug2) : BE0000262 Prostaglandin G/H synthase 2 (-1) --------------------------------------------------- Drug1 : DB00154 Dihomo-gamma-linolenic acid Drug2 : DB06725 Lornoxicam Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Non-common off-target(s) (drug2) : BE0000262 Prostaglandin G/H synthase 2 (-1) --------------------------------------------------- Drug1 : DB00159 Icosapent Drug2 : DB00244 Mesalazine Pharmacological target (+,+) : BE0000215 Peroxisome proliferator-activated receptor gamma Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000888 Fatty acid desaturase 1 (1) BE0000986 Sodium/calcium exchanger 1 (-1) BE0001023 Transient receptor potential cation channel subfamily V member 1 (1) BE0001007 Peroxisome proliferator-activated receptor delta (1) BE0000996 Long-chain-fatty-acid--CoA ligase 4 (1) BE0001093 Long-chain-fatty-acid--CoA ligase 3 (1) BE0000688 Free fatty acid receptor 1 (1) Non-common off-target(s) (drug2) : BE0000248 Arachidonate 5-lipoxygenase (-1) BE0004655 Inhibitor of nuclear factor kappa-B kinase subunit alpha (-1) BE0001154 Inhibitor of nuclear factor kappa-B kinase subunit beta (-1) --------------------------------------------------- Drug1 : DB00159 Icosapent Drug2 : DB00795 Sulfasalazine Pharmacological target (+,+) : BE0000215 Peroxisome proliferator-activated receptor gamma Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000888 Fatty acid desaturase 1 (1) BE0000986 Sodium/calcium exchanger 1 (-1) BE0001023 Transient receptor potential cation channel subfamily V member 1 (1) BE0001007 Peroxisome proliferator-activated receptor delta (1) BE0000996 Long-chain-fatty-acid--CoA ligase 4 (1) BE0001093 Long-chain-fatty-acid--CoA ligase 3 (1) BE0000688 Free fatty acid receptor 1 (1) Non-common off-target(s) (drug2) : BE0000030 Cystine/glutamate transporter (-1) BE0000248 Arachidonate 5-lipoxygenase (-1) BE0004655 Inhibitor of nuclear factor kappa-B kinase subunit alpha (-1) BE0001154 Inhibitor of nuclear factor kappa-B kinase subunit beta (-1) BE0000069 Acetyl-CoA acetyltransferase, mitochondrial (-1) BE0001893 Thromboxane-A synthase (-1) BE0003997 Phospholipase A2 (-1) --------------------------------------------------- Drug1 : DB00159 Icosapent Drug2 : DB01014 Balsalazide Pharmacological target (+,+) : BE0000215 Peroxisome proliferator-activated receptor gamma Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000888 Fatty acid desaturase 1 (1) BE0000986 Sodium/calcium exchanger 1 (-1) BE0001023 Transient receptor potential cation channel subfamily V member 1 (1) BE0001007 Peroxisome proliferator-activated receptor delta (1) BE0000996 Long-chain-fatty-acid--CoA ligase 4 (1) BE0001093 Long-chain-fatty-acid--CoA ligase 3 (1) BE0000688 Free fatty acid receptor 1 (1) Non-common off-target(s) (drug2) : BE0000248 Arachidonate 5-lipoxygenase (-1) --------------------------------------------------- Drug1 : DB00169 Cholecalciferol Drug2 : DB00910 Paricalcitol Pharmacological target (+,+) : BE0000779 Vitamin D3 receptor --------------------------------------------------- Drug1 : DB00169 Cholecalciferol Drug2 : DB01070 Dihydrotachysterol Pharmacological target (+,+) : BE0000779 Vitamin D3 receptor --------------------------------------------------- Drug1 : DB00169 Cholecalciferol Drug2 : DB01436 Alfacalcidol Pharmacological target (+,+) : BE0000779 Vitamin D3 receptor --------------------------------------------------- Drug1 : DB00175 Pravastatin Drug2 : DB00227 Lovastatin Pharmacological target (-,-) : BE0000574 3-hydroxy-3-methylglutaryl-coenzyme A reductase --------------------------------------------------- Drug1 : DB00175 Pravastatin Drug2 : DB00439 Cerivastatin Pharmacological target (-,-) : BE0000574 3-hydroxy-3-methylglutaryl-coenzyme A reductase --------------------------------------------------- Drug1 : DB00175 Pravastatin Drug2 : DB00641 Simvastatin Pharmacological target (-,-) : BE0000574 3-hydroxy-3-methylglutaryl-coenzyme A reductase --------------------------------------------------- Drug1 : DB00175 Pravastatin Drug2 : DB01076 Atorvastatin Pharmacological target (-,-) : BE0000574 3-hydroxy-3-methylglutaryl-coenzyme A reductase Non-common off-target(s) (drug2) : BE0003721 Aryl hydrocarbon receptor (1) BE0000854 Dipeptidyl peptidase 4 (-1) --------------------------------------------------- Drug1 : DB00175 Pravastatin Drug2 : DB01095 Fluvastatin Pharmacological target (-,-) : BE0000574 3-hydroxy-3-methylglutaryl-coenzyme A reductase --------------------------------------------------- Drug1 : DB00175 Pravastatin Drug2 : DB01098 Rosuvastatin Pharmacological target (-,-) : BE0000574 3-hydroxy-3-methylglutaryl-coenzyme A reductase --------------------------------------------------- Drug1 : DB00175 Pravastatin Drug2 : DB06693 Mevastatin Pharmacological target (-,-) : BE0000574 3-hydroxy-3-methylglutaryl-coenzyme A reductase --------------------------------------------------- Drug1 : DB00175 Pravastatin Drug2 : DB08860 Pitavastatin Pharmacological target (-,-) : BE0000574 3-hydroxy-3-methylglutaryl-coenzyme A reductase --------------------------------------------------- Drug1 : DB00176 Fluvoxamine Drug2 : DB00215 Citalopram Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter --------------------------------------------------- Drug1 : DB00176 Fluvoxamine Drug2 : DB00285 Venlafaxine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB00176 Fluvoxamine Drug2 : DB00344 Protriptyline Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug2) : BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB00176 Fluvoxamine Drug2 : DB00458 Imipramine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug2) : BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0003603 Potassium voltage-gated channel subfamily D member 2 (-1) BE0003604 Potassium voltage-gated channel subfamily D member 3 (-1) --------------------------------------------------- Drug1 : DB00176 Fluvoxamine Drug2 : DB00472 Fluoxetine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter --------------------------------------------------- Drug1 : DB00176 Fluvoxamine Drug2 : DB00476 Duloxetine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB00176 Fluvoxamine Drug2 : DB00543 Amoxapine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug2) : BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000756 D(2) dopamine receptor (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000797 5-hydroxytryptamine receptor 1B (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0004864 Alpha-2 adrenergic receptor (-1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0004863 Alpha-1 adrenergic receptor (-1) BE0004890 Muscarinic acetylcholine receptor (-1) --------------------------------------------------- Drug1 : DB00176 Fluvoxamine Drug2 : DB00715 Paroxetine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug2) : BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00176 Fluvoxamine Drug2 : DB00726 Trimipramine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (1) BE0000289 Alpha-2A adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00176 Fluvoxamine Drug2 : DB01104 Sertraline Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB00176 Fluvoxamine Drug2 : DB01175 Escitalopram Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) --------------------------------------------------- Drug1 : DB00176 Fluvoxamine Drug2 : DB01191 Dexfenfluramine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug2) : BE0000533 5-hydroxytryptamine receptor 2C (1) --------------------------------------------------- Drug1 : DB00176 Fluvoxamine Drug2 : DB04896 Milnacipran Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug2) : BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0004956 NMDA receptor (-1) --------------------------------------------------- Drug1 : DB00176 Fluvoxamine Drug2 : DB06700 Desvenlafaxine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug2) : BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB00176 Fluvoxamine Drug2 : DB08918 Levomilnacipran Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug2) : BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB00177 Valsartan Drug2 : DB00275 Olmesartan Pharmacological target (-,-) : BE0000062 Type-1 angiotensin II receptor --------------------------------------------------- Drug1 : DB00177 Valsartan Drug2 : DB00678 Losartan Pharmacological target (-,-) : BE0000062 Type-1 angiotensin II receptor --------------------------------------------------- Drug1 : DB00177 Valsartan Drug2 : DB00796 Candesartan Pharmacological target (-,-) : BE0000062 Type-1 angiotensin II receptor --------------------------------------------------- Drug1 : DB00177 Valsartan Drug2 : DB00876 Eprosartan Pharmacological target (-,-) : BE0000062 Type-1 angiotensin II receptor --------------------------------------------------- Drug1 : DB00177 Valsartan Drug2 : DB00966 Telmisartan Pharmacological target (-,-) : BE0000062 Type-1 angiotensin II receptor Non-common off-target(s) (drug2) : BE0000215 Peroxisome proliferator-activated receptor gamma (1) --------------------------------------------------- Drug1 : DB00177 Valsartan Drug2 : DB01029 Irbesartan Pharmacological target (-,-) : BE0000062 Type-1 angiotensin II receptor --------------------------------------------------- Drug1 : DB00177 Valsartan Drug2 : DB01342 Forasartan Pharmacological target (-,-) : BE0000062 Type-1 angiotensin II receptor --------------------------------------------------- Drug1 : DB00177 Valsartan Drug2 : DB01347 Saprisartan Pharmacological target (-,-) : BE0000062 Type-1 angiotensin II receptor --------------------------------------------------- Drug1 : DB00177 Valsartan Drug2 : DB01349 Tasosartan Pharmacological target (-,-) : BE0000062 Type-1 angiotensin II receptor Non-common off-target(s) (drug2) : BE0003426 Type-2 angiotensin II receptor (-1) --------------------------------------------------- Drug1 : DB00177 Valsartan Drug2 : DB08822 Azilsartan medoxomil Pharmacological target (-,-) : BE0000062 Type-1 angiotensin II receptor --------------------------------------------------- Drug1 : DB00178 Ramipril Drug2 : DB00492 Fosinopril Pharmacological target (-,-) : BE0000221 Angiotensin-converting enzyme --------------------------------------------------- Drug1 : DB00178 Ramipril Drug2 : DB00519 Trandolapril Pharmacological target (-,-) : BE0000221 Angiotensin-converting enzyme --------------------------------------------------- Drug1 : DB00178 Ramipril Drug2 : DB00542 Benazepril Pharmacological target (-,-) : BE0000221 Angiotensin-converting enzyme --------------------------------------------------- Drug1 : DB00178 Ramipril Drug2 : DB00584 Enalapril Pharmacological target (-,-) : BE0000221 Angiotensin-converting enzyme --------------------------------------------------- Drug1 : DB00178 Ramipril Drug2 : DB00691 Moexipril Pharmacological target (-,-) : BE0000221 Angiotensin-converting enzyme Non-common off-target(s) (drug2) : BE0000982 Angiotensin-converting enzyme 2 (-1) --------------------------------------------------- Drug1 : DB00178 Ramipril Drug2 : DB00722 Lisinopril Pharmacological target (-,-) : BE0000221 Angiotensin-converting enzyme Non-common off-target(s) (drug2) : BE0000982 Angiotensin-converting enzyme 2 (-1) --------------------------------------------------- Drug1 : DB00178 Ramipril Drug2 : DB00790 Perindopril Pharmacological target (-,-) : BE0000221 Angiotensin-converting enzyme --------------------------------------------------- Drug1 : DB00178 Ramipril Drug2 : DB00881 Quinapril Pharmacological target (-,-) : BE0000221 Angiotensin-converting enzyme --------------------------------------------------- Drug1 : DB00178 Ramipril Drug2 : DB01180 Rescinnamine Pharmacological target (-,-) : BE0000221 Angiotensin-converting enzyme --------------------------------------------------- Drug1 : DB00178 Ramipril Drug2 : DB01197 Captopril Pharmacological target (-,-) : BE0000221 Angiotensin-converting enzyme Non-common off-target(s) (drug2) : BE0000642 72 kDa type IV collagenase (-1) BE0000058 Matrix metalloproteinase-9 (-1) --------------------------------------------------- Drug1 : DB00178 Ramipril Drug2 : DB01340 Cilazapril Pharmacological target (-,-) : BE0000221 Angiotensin-converting enzyme --------------------------------------------------- Drug1 : DB00178 Ramipril Drug2 : DB01348 Spirapril Pharmacological target (-,-) : BE0000221 Angiotensin-converting enzyme --------------------------------------------------- Drug1 : DB00179 Masoprocol Drug2 : DB00711 Diethylcarbamazine Pharmacological target (-,-) : BE0000248 Arachidonate 5-lipoxygenase Non-common off-target(s) (drug2) : BE0000017 Prostaglandin G/H synthase 1 (-1) --------------------------------------------------- Drug1 : DB00179 Masoprocol Drug2 : DB00744 Zileuton Pharmacological target (-,-) : BE0000248 Arachidonate 5-lipoxygenase --------------------------------------------------- Drug1 : DB00180 Flunisolide Drug2 : DB00223 Diflorasone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00180 Flunisolide Drug2 : DB00240 Alclometasone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00180 Flunisolide Drug2 : DB00253 Medrysone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00180 Flunisolide Drug2 : DB00288 Amcinonide Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug2) : BE0000422 Annexin A1 (1) --------------------------------------------------- Drug1 : DB00180 Flunisolide Drug2 : DB00324 Fluorometholone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00180 Flunisolide Drug2 : DB00394 Beclomethasone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00180 Flunisolide Drug2 : DB00443 Betamethasone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00180 Flunisolide Drug2 : DB00547 Desoximetasone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00180 Flunisolide Drug2 : DB00588 Fluticasone Propionate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug2) : BE0000557 Progesterone receptor (1) BE0000668 Mineralocorticoid receptor (-1) BE0000657 Cytosolic phospholipase A2 (-1) --------------------------------------------------- Drug1 : DB00180 Flunisolide Drug2 : DB00591 Fluocinolone Acetonide Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00180 Flunisolide Drug2 : DB00596 Halobetasol Propionate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00180 Flunisolide Drug2 : DB00620 Triamcinolone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00180 Flunisolide Drug2 : DB00635 Prednisone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00180 Flunisolide Drug2 : DB00663 Flumethasone Pivalate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00180 Flunisolide Drug2 : DB00741 Hydrocortisone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug2) : BE0000422 Annexin A1 (1) --------------------------------------------------- Drug1 : DB00180 Flunisolide Drug2 : DB00764 Mometasone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00180 Flunisolide Drug2 : DB00769 Hydrocortamate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00180 Flunisolide Drug2 : DB00838 Clocortolone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00180 Flunisolide Drug2 : DB00846 Flurandrenolide Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00180 Flunisolide Drug2 : DB00860 Prednisolone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00180 Flunisolide Drug2 : DB00873 Loteprednol Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00180 Flunisolide Drug2 : DB00896 Rimexolone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00180 Flunisolide Drug2 : DB00959 Methylprednisolone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00180 Flunisolide Drug2 : DB01013 Clobetasol propionate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00180 Flunisolide Drug2 : DB01047 Fluocinonide Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug2) : BE0004659 Smoothened homolog (1) --------------------------------------------------- Drug1 : DB00180 Flunisolide Drug2 : DB01130 Prednicarbate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00180 Flunisolide Drug2 : DB01234 Dexamethasone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug2) : BE0000005 Nitric oxide synthase, inducible (-1) BE0000422 Annexin A1 (1) BE0000074 Nuclear receptor subfamily 0 group B member 1 (1) --------------------------------------------------- Drug1 : DB00180 Flunisolide Drug2 : DB01260 Desonide Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00180 Flunisolide Drug2 : DB01380 Cortisone acetate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00180 Flunisolide Drug2 : DB01384 Paramethasone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00180 Flunisolide Drug2 : DB01410 Ciclesonide Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00180 Flunisolide Drug2 : DB06781 Difluprednate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00180 Flunisolide Drug2 : DB08906 Fluticasone furoate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00181 Baclofen Drug2 : DB00837 Progabide Pharmacological target (+,+) : BE0000217 Gamma-aminobutyric acid type B receptor subunit 1 Non-common off-target(s) (drug1) : BE0002340 Gamma-aminobutyric acid type B receptor subunit 2 (1) Non-common off-target(s) (drug2) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) --------------------------------------------------- Drug1 : DB00181 Baclofen Drug2 : DB01080 Vigabatrin Pharmacological target (+,+) : BE0000217 Gamma-aminobutyric acid type B receptor subunit 1 Non-common off-target(s) (drug1) : BE0002340 Gamma-aminobutyric acid type B receptor subunit 2 (1) Non-common off-target(s) (drug2) : BE0000253 4-aminobutyrate aminotransferase, mitochondrial (-1) --------------------------------------------------- Drug1 : DB00181 Baclofen Drug2 : DB08891 Arbaclofen Pharmacological target (+,+) : BE0000217 Gamma-aminobutyric acid type B receptor subunit 1 Pharmacological target (+,+) : BE0002340 Gamma-aminobutyric acid type B receptor subunit 2 --------------------------------------------------- Drug1 : DB00181 Baclofen Drug2 : DB08892 Arbaclofen Placarbil Pharmacological target (+,+) : BE0000217 Gamma-aminobutyric acid type B receptor subunit 1 Pharmacological target (+,+) : BE0002340 Gamma-aminobutyric acid type B receptor subunit 2 --------------------------------------------------- Drug1 : DB00185 Cevimeline Drug2 : DB01085 Pilocarpine Pharmacological target (+,+) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (+,+) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug2) : BE0000560 Muscarinic acetylcholine receptor M2 (1) --------------------------------------------------- Drug1 : DB00185 Cevimeline Drug2 : DB01233 Metoclopramide Pharmacological target (+,+) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000311 5-hydroxytryptamine receptor 3A (1) BE0000084 5-hydroxytryptamine receptor 4 (1) --------------------------------------------------- Drug1 : DB00185 Cevimeline Drug2 : DB06709 Methacholine Pharmacological target (+,+) : BE0000045 Muscarinic acetylcholine receptor M3 Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (1) --------------------------------------------------- Drug1 : DB00186 Lorazepam Drug2 : DB00189 Ethchlorvynol Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) --------------------------------------------------- Drug1 : DB00186 Lorazepam Drug2 : DB00237 Butabarbital Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) --------------------------------------------------- Drug1 : DB00186 Lorazepam Drug2 : DB00349 Clobazam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) --------------------------------------------------- Drug1 : DB00186 Lorazepam Drug2 : DB00404 Alprazolam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) --------------------------------------------------- Drug1 : DB00186 Lorazepam Drug2 : DB00475 Chlordiazepoxide Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) --------------------------------------------------- Drug1 : DB00186 Lorazepam Drug2 : DB00628 Clorazepate Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug2) : BE0000736 Translocator protein (1) --------------------------------------------------- Drug1 : DB00186 Lorazepam Drug2 : DB01068 Clonazepam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) --------------------------------------------------- Drug1 : DB00186 Lorazepam Drug2 : DB01107 Methyprylon Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug2) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) --------------------------------------------------- Drug1 : DB00186 Lorazepam Drug2 : DB01159 Halothane Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug2) : BE0000534 Glutamate receptor ionotropic, NMDA 3B (-1) BE0000760 Glutamate receptor ionotropic, NMDA 2A (-1) BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000503 NADH-ubiquinone oxidoreductase chain 1 (-1) BE0000415 Intermediate conductance calcium-activated potassium channel protein 4 (-1) BE0000553 Calcium-activated potassium channel subunit alpha-1 (-1) BE0001028 G protein-activated inward rectifier potassium channel 1 (-1) BE0001030 G protein-activated inward rectifier potassium channel 2 (-1) --------------------------------------------------- Drug1 : DB00186 Lorazepam Drug2 : DB01437 Glutethimide Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug2) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) --------------------------------------------------- Drug1 : DB00187 Esmolol Drug2 : DB00195 Betaxolol Pharmacological target (-,-) : BE0000172 Beta-1 adrenergic receptor Non-common off-target(s) (drug2) : BE0000694 Beta-2 adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00187 Esmolol Drug2 : DB00264 Metoprolol Pharmacological target (-,-) : BE0000172 Beta-1 adrenergic receptor Non-common off-target(s) (drug2) : BE0000694 Beta-2 adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00187 Esmolol Drug2 : DB00335 Atenolol Pharmacological target (-,-) : BE0000172 Beta-1 adrenergic receptor --------------------------------------------------- Drug1 : DB00187 Esmolol Drug2 : DB00373 Timolol Pharmacological target (-,-) : BE0000172 Beta-1 adrenergic receptor Non-common off-target(s) (drug2) : BE0000694 Beta-2 adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00187 Esmolol Drug2 : DB00571 Propranolol Pharmacological target (-,-) : BE0000172 Beta-1 adrenergic receptor Non-common off-target(s) (drug2) : BE0000694 Beta-2 adrenergic receptor (-1) BE0001012 Beta-3 adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00187 Esmolol Drug2 : DB00612 Bisoprolol Pharmacological target (-,-) : BE0000172 Beta-1 adrenergic receptor Non-common off-target(s) (drug2) : BE0000694 Beta-2 adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00187 Esmolol Drug2 : DB01136 Carvedilol Pharmacological target (-,-) : BE0000172 Beta-1 adrenergic receptor Non-common off-target(s) (drug2) : BE0000173 NADH dehydrogenase [ubiquinone] 1 subunit C2 (-1) BE0000694 Beta-2 adrenergic receptor (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0001114 Vascular cell adhesion protein 1 (-1) BE0001074 E-selectin (-1) --------------------------------------------------- Drug1 : DB00187 Esmolol Drug2 : DB01203 Nadolol Pharmacological target (-,-) : BE0000172 Beta-1 adrenergic receptor Non-common off-target(s) (drug2) : BE0000694 Beta-2 adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00187 Esmolol Drug2 : DB01210 Levobunolol Pharmacological target (-,-) : BE0000172 Beta-1 adrenergic receptor Non-common off-target(s) (drug2) : BE0000694 Beta-2 adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00187 Esmolol Drug2 : DB01214 Metipranolol Pharmacological target (-,-) : BE0000172 Beta-1 adrenergic receptor Non-common off-target(s) (drug2) : BE0000694 Beta-2 adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00187 Esmolol Drug2 : DB01295 Bevantolol Pharmacological target (-,-) : BE0000172 Beta-1 adrenergic receptor Non-common off-target(s) (drug2) : BE0000694 Beta-2 adrenergic receptor (-1) BE0000501 Alpha-1A adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00187 Esmolol Drug2 : DB01297 Practolol Pharmacological target (-,-) : BE0000172 Beta-1 adrenergic receptor --------------------------------------------------- Drug1 : DB00187 Esmolol Drug2 : DB01580 Oxprenolol Pharmacological target (-,-) : BE0000172 Beta-1 adrenergic receptor Non-common off-target(s) (drug2) : BE0000694 Beta-2 adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00187 Esmolol Drug2 : DB04861 Nebivolol Pharmacological target (-,-) : BE0000172 Beta-1 adrenergic receptor Non-common off-target(s) (drug2) : BE0000694 Beta-2 adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00187 Esmolol Drug2 : DB08808 Bupranolol Pharmacological target (-,-) : BE0000172 Beta-1 adrenergic receptor Non-common off-target(s) (drug2) : BE0000694 Beta-2 adrenergic receptor (-1) BE0001012 Beta-3 adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00188 Bortezomib Drug2 : DB08889 Carfilzomib Pharmacological target (-,-) : BE0002347 Proteasome subunit beta type-1 Pharmacological target (-,-) : BE0002348 Proteasome subunit beta type-5 Pharmacological target (-,-) : BE0002349 Proteasome subunit beta type-2 Non-common off-target(s) (drug1) : BE0000470 26S proteasome non-ATPase regulatory subunit 2 (-1) BE0000463 26S proteasome non-ATPase regulatory subunit 1 (-1) Non-common off-target(s) (drug2) : BE0004739 Proteasome subunit beta type-8 (-1) BE0004737 Proteasome subunit beta type-9 (-1) BE0004738 Proteasome subunit beta type-10 (-1) --------------------------------------------------- Drug1 : DB00189 Ethchlorvynol Drug2 : DB00237 Butabarbital Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) --------------------------------------------------- Drug1 : DB00189 Ethchlorvynol Drug2 : DB00349 Clobazam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) --------------------------------------------------- Drug1 : DB00189 Ethchlorvynol Drug2 : DB00404 Alprazolam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) --------------------------------------------------- Drug1 : DB00189 Ethchlorvynol Drug2 : DB00475 Chlordiazepoxide Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) --------------------------------------------------- Drug1 : DB00189 Ethchlorvynol Drug2 : DB00628 Clorazepate Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug2) : BE0000736 Translocator protein (1) --------------------------------------------------- Drug1 : DB00189 Ethchlorvynol Drug2 : DB01068 Clonazepam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) --------------------------------------------------- Drug1 : DB00189 Ethchlorvynol Drug2 : DB01107 Methyprylon Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug2) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) --------------------------------------------------- Drug1 : DB00189 Ethchlorvynol Drug2 : DB01159 Halothane Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug2) : BE0000534 Glutamate receptor ionotropic, NMDA 3B (-1) BE0000760 Glutamate receptor ionotropic, NMDA 2A (-1) BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000503 NADH-ubiquinone oxidoreductase chain 1 (-1) BE0000415 Intermediate conductance calcium-activated potassium channel protein 4 (-1) BE0000553 Calcium-activated potassium channel subunit alpha-1 (-1) BE0001028 G protein-activated inward rectifier potassium channel 1 (-1) BE0001030 G protein-activated inward rectifier potassium channel 2 (-1) --------------------------------------------------- Drug1 : DB00189 Ethchlorvynol Drug2 : DB01437 Glutethimide Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug2) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) --------------------------------------------------- Drug1 : DB00191 Phentermine Drug2 : DB00579 Mazindol Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) --------------------------------------------------- Drug1 : DB00191 Phentermine Drug2 : DB00852 Pseudoephedrine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) Non-common off-target(s) (drug2) : BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00191 Phentermine Drug2 : DB00907 Cocaine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) Non-common off-target(s) (drug2) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000197 Sodium channel protein type 5 subunit alpha (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) BE0000192 Sodium channel protein type 11 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00191 Phentermine Drug2 : DB01105 Sibutramine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) --------------------------------------------------- Drug1 : DB00191 Phentermine Drug2 : DB01442 MMDA Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Pharmacological target (-,-) : BE0002196 Amine oxidase [flavin-containing] B Pharmacological target (-,-) : BE0002198 Amine oxidase [flavin-containing] A Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (-1) BE0004674 Chromaffin granule amine transporter (-1) BE0000451 5-hydroxytryptamine receptor 2A (1) --------------------------------------------------- Drug1 : DB00192 Indecainide Drug2 : DB00243 Ranolazine Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug2) : BE0001143 Sodium channel protein type 9 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00192 Indecainide Drug2 : DB00252 Phenytoin Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug2) : BE0000141 Sodium channel protein type 1 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00192 Indecainide Drug2 : DB00280 Disopyramide Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0003603 Potassium voltage-gated channel subfamily D member 2 (-1) BE0003604 Potassium voltage-gated channel subfamily D member 3 (-1) --------------------------------------------------- Drug1 : DB00192 Indecainide Drug2 : DB00379 Mexiletine Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug2) : BE0003721 Aryl hydrocarbon receptor (1) --------------------------------------------------- Drug1 : DB00192 Indecainide Drug2 : DB00473 Hexylcaine Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug2) : BE0000177 Sodium channel protein type 10 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00192 Indecainide Drug2 : DB00527 Cinchocaine Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug2) : BE0000177 Sodium channel protein type 10 subunit alpha (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00192 Indecainide Drug2 : DB00532 Mephenytoin Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha --------------------------------------------------- Drug1 : DB00192 Indecainide Drug2 : DB00564 Carbamazepine Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha --------------------------------------------------- Drug1 : DB00192 Indecainide Drug2 : DB00680 Moricizine Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha --------------------------------------------------- Drug1 : DB00192 Indecainide Drug2 : DB00740 Riluzole Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug2) : BE0000030 Cystine/glutamate transporter (1) --------------------------------------------------- Drug1 : DB00192 Indecainide Drug2 : DB00750 Prilocaine Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha --------------------------------------------------- Drug1 : DB00192 Indecainide Drug2 : DB00754 Ethotoin Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha --------------------------------------------------- Drug1 : DB00192 Indecainide Drug2 : DB00776 Oxcarbazepine Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha --------------------------------------------------- Drug1 : DB00192 Indecainide Drug2 : DB00908 Quinidine Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug2) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000154 Potassium channel subfamily K member 1 (-1) BE0000680 Potassium channel subfamily K member 6 (-1) --------------------------------------------------- Drug1 : DB00192 Indecainide Drug2 : DB01056 Tocainide Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha --------------------------------------------------- Drug1 : DB00192 Indecainide Drug2 : DB01182 Propafenone Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug2) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) --------------------------------------------------- Drug1 : DB00192 Indecainide Drug2 : DB01195 Flecainide Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug2) : BE0002083 Sodium channel protein type 4 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00192 Indecainide Drug2 : DB01228 Encainide Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha --------------------------------------------------- Drug1 : DB00192 Indecainide Drug2 : DB01320 Fosphenytoin Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha --------------------------------------------------- Drug1 : DB00192 Indecainide Drug2 : DB01426 Ajmaline Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha --------------------------------------------------- Drug1 : DB00192 Indecainide Drug2 : DB01429 Aprindine Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug2) : BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00193 Tramadol Drug2 : DB00285 Venlafaxine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000770 Mu-type opioid receptor (1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) BE0003438 Alpha-7 nicotinic cholinergic receptor subunit (-1) Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB00193 Tramadol Drug2 : DB00344 Protriptyline Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000770 Mu-type opioid receptor (1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) BE0003438 Alpha-7 nicotinic cholinergic receptor subunit (-1) --------------------------------------------------- Drug1 : DB00193 Tramadol Drug2 : DB00476 Duloxetine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000770 Mu-type opioid receptor (1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) BE0003438 Alpha-7 nicotinic cholinergic receptor subunit (-1) Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB00193 Tramadol Drug2 : DB00579 Mazindol Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000770 Mu-type opioid receptor (1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) BE0003438 Alpha-7 nicotinic cholinergic receptor subunit (-1) Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB00193 Tramadol Drug2 : DB00907 Cocaine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000770 Mu-type opioid receptor (1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) BE0003438 Alpha-7 nicotinic cholinergic receptor subunit (-1) Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000197 Sodium channel protein type 5 subunit alpha (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) BE0000192 Sodium channel protein type 11 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00193 Tramadol Drug2 : DB01105 Sibutramine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000770 Mu-type opioid receptor (1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) BE0003438 Alpha-7 nicotinic cholinergic receptor subunit (-1) Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB00193 Tramadol Drug2 : DB04896 Milnacipran Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000770 Mu-type opioid receptor (1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) BE0003438 Alpha-7 nicotinic cholinergic receptor subunit (-1) Non-common off-target(s) (drug2) : BE0004956 NMDA receptor (-1) --------------------------------------------------- Drug1 : DB00193 Tramadol Drug2 : DB06700 Desvenlafaxine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000770 Mu-type opioid receptor (1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) BE0003438 Alpha-7 nicotinic cholinergic receptor subunit (-1) --------------------------------------------------- Drug1 : DB00193 Tramadol Drug2 : DB08918 Levomilnacipran Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000770 Mu-type opioid receptor (1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) BE0003438 Alpha-7 nicotinic cholinergic receptor subunit (-1) --------------------------------------------------- Drug1 : DB00195 Betaxolol Drug2 : DB00335 Atenolol Pharmacological target (-,-) : BE0000172 Beta-1 adrenergic receptor Non-common off-target(s) (drug1) : BE0000694 Beta-2 adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00195 Betaxolol Drug2 : DB01297 Practolol Pharmacological target (-,-) : BE0000172 Beta-1 adrenergic receptor Non-common off-target(s) (drug1) : BE0000694 Beta-2 adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00197 Troglitazone Drug2 : DB00966 Telmisartan Pharmacological target (+,+) : BE0000215 Peroxisome proliferator-activated receptor gamma Non-common off-target(s) (drug1) : BE0000240 Plasminogen activator inhibitor 1 (-1) BE0000996 Long-chain-fatty-acid--CoA ligase 4 (-1) BE0001204 Equilibrative nucleoside transporter 1 (-1) BE0002088 Estrogen-related receptor gamma (-1) BE0003722 Steroid hormone receptor ERR1 (-1) Non-common off-target(s) (drug2) : BE0000062 Type-1 angiotensin II receptor (-1) --------------------------------------------------- Drug1 : DB00197 Troglitazone Drug2 : DB01132 Pioglitazone Pharmacological target (+,+) : BE0000215 Peroxisome proliferator-activated receptor gamma Non-common off-target(s) (drug1) : BE0000240 Plasminogen activator inhibitor 1 (-1) BE0000996 Long-chain-fatty-acid--CoA ligase 4 (-1) BE0001204 Equilibrative nucleoside transporter 1 (-1) BE0002088 Estrogen-related receptor gamma (-1) BE0003722 Steroid hormone receptor ERR1 (-1) --------------------------------------------------- Drug1 : DB00197 Troglitazone Drug2 : DB08915 Aleglitazar Pharmacological target (+,+) : BE0000215 Peroxisome proliferator-activated receptor gamma Non-common off-target(s) (drug1) : BE0000240 Plasminogen activator inhibitor 1 (-1) BE0000996 Long-chain-fatty-acid--CoA ligase 4 (-1) BE0001204 Equilibrative nucleoside transporter 1 (-1) BE0002088 Estrogen-related receptor gamma (-1) BE0003722 Steroid hormone receptor ERR1 (-1) Non-common off-target(s) (drug2) : BE0000071 Peroxisome proliferator-activated receptor alpha (1) --------------------------------------------------- Drug1 : DB00203 Sildenafil Drug2 : DB00820 Tadalafil Pharmacological target (-,-) : BE0000182 cGMP-specific 3',5'-cyclic phosphodiesterase Non-common off-target(s) (drug1) : BE0003556 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (-1) BE0003557 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (-1) Non-common off-target(s) (drug2) : BE0003558 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (-1) --------------------------------------------------- Drug1 : DB00203 Sildenafil Drug2 : DB00862 Vardenafil Pharmacological target (-,-) : BE0000182 cGMP-specific 3',5'-cyclic phosphodiesterase Non-common off-target(s) (drug1) : BE0003556 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (-1) BE0003557 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (-1) --------------------------------------------------- Drug1 : DB00203 Sildenafil Drug2 : DB06237 Avanafil Pharmacological target (-,-) : BE0000182 cGMP-specific 3',5'-cyclic phosphodiesterase Non-common off-target(s) (drug1) : BE0003556 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (-1) BE0003557 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (-1) --------------------------------------------------- Drug1 : DB00203 Sildenafil Drug2 : DB06267 Udenafil Pharmacological target (-,-) : BE0000182 cGMP-specific 3',5'-cyclic phosphodiesterase Non-common off-target(s) (drug1) : BE0003556 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (-1) BE0003557 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (-1) --------------------------------------------------- Drug1 : DB00205 Pyrimethamine Drug2 : DB00563 Methotrexate Pharmacological target (-,-) : BE0000330 Dihydrofolate reductase --------------------------------------------------- Drug1 : DB00205 Pyrimethamine Drug2 : DB01131 Proguanil Pharmacological target (-,-) : BE0000330 Dihydrofolate reductase --------------------------------------------------- Drug1 : DB00205 Pyrimethamine Drug2 : DB01157 Trimetrexate Pharmacological target (-,-) : BE0000330 Dihydrofolate reductase --------------------------------------------------- Drug1 : DB00205 Pyrimethamine Drug2 : DB06813 Pralatrexate Pharmacological target (-,-) : BE0000330 Dihydrofolate reductase Non-common off-target(s) (drug2) : BE0000324 Thymidylate synthase (-1) --------------------------------------------------- Drug1 : DB00206 Reserpine Drug2 : DB00386 Alseroxylon Pharmacological target (-,-) : BE0000118 Synaptic vesicular amine transporter --------------------------------------------------- Drug1 : DB00206 Reserpine Drug2 : DB01089 Deserpidine Pharmacological target (-,-) : BE0000118 Synaptic vesicular amine transporter --------------------------------------------------- Drug1 : DB00206 Reserpine Drug2 : DB04844 Tetrabenazine Pharmacological target (-,-) : BE0000118 Synaptic vesicular amine transporter Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00206 Reserpine Drug2 : DB06706 Isometheptene Pharmacological target (-,-) : BE0000118 Synaptic vesicular amine transporter Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00208 Ticlopidine Drug2 : DB00758 Clopidogrel Pharmacological target (-,-) : BE0000110 P2Y purinoceptor 12 --------------------------------------------------- Drug1 : DB00208 Ticlopidine Drug2 : DB06209 Prasugrel Pharmacological target (-,-) : BE0000110 P2Y purinoceptor 12 --------------------------------------------------- Drug1 : DB00208 Ticlopidine Drug2 : DB08816 Ticagrelor Pharmacological target (-,-) : BE0000110 P2Y purinoceptor 12 --------------------------------------------------- Drug1 : DB00210 Adapalene Drug2 : DB00307 Bexarotene Pharmacological target (+,+) : BE0000707 Retinoic acid receptor RXR-gamma Pharmacological target (+,+) : BE0000078 Retinoic acid receptor RXR-beta Non-common off-target(s) (drug1) : BE0000144 Retinoic acid receptor gamma (1) BE0000206 Retinoic acid receptor beta (1) BE0000663 Retinoic acid receptor alpha (1) Non-common off-target(s) (drug2) : BE0000412 Retinoic acid receptor RXR-alpha (1) --------------------------------------------------- Drug1 : DB00210 Adapalene Drug2 : DB00755 Tretinoin Pharmacological target (+,+) : BE0000144 Retinoic acid receptor gamma Pharmacological target (+,+) : BE0000707 Retinoic acid receptor RXR-gamma Pharmacological target (+,+) : BE0000078 Retinoic acid receptor RXR-beta Non-common off-target(s) (drug1) : BE0000206 Retinoic acid receptor beta (1) BE0000663 Retinoic acid receptor alpha (1) Non-common off-target(s) (drug2) : BE0000653 Retinoic acid receptor responder protein 1 (1) --------------------------------------------------- Drug1 : DB00211 Midodrine Drug2 : DB00397 Phenylpropanolamine Pharmacological target (+,+) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000020 D(1A) dopamine receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00211 Midodrine Drug2 : DB00610 Metaraminol Pharmacological target (+,+) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00211 Midodrine Drug2 : DB00964 Apraclonidine Pharmacological target (+,+) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00211 Midodrine Drug2 : DB01253 Ergonovine Pharmacological target (+,+) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00211 Midodrine Drug2 : DB06706 Isometheptene Pharmacological target (+,+) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (-1) --------------------------------------------------- Drug1 : DB00211 Midodrine Drug2 : DB06707 Levonordefrin Pharmacological target (+,+) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB00211 Midodrine Drug2 : DB06711 Naphazoline Pharmacological target (+,+) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00213 Pantoprazole Drug2 : DB00338 Omeprazole Pharmacological target (-,-) : BE0000349 Potassium-transporting ATPase alpha chain 1 --------------------------------------------------- Drug1 : DB00213 Pantoprazole Drug2 : DB00448 Lansoprazole Pharmacological target (-,-) : BE0000349 Potassium-transporting ATPase alpha chain 1 --------------------------------------------------- Drug1 : DB00213 Pantoprazole Drug2 : DB00736 Esomeprazole Pharmacological target (-,-) : BE0000349 Potassium-transporting ATPase alpha chain 1 --------------------------------------------------- Drug1 : DB00213 Pantoprazole Drug2 : DB01129 Rabeprazole Pharmacological target (-,-) : BE0000349 Potassium-transporting ATPase alpha chain 1 --------------------------------------------------- Drug1 : DB00214 Torasemide Drug2 : DB00232 Methyclothiazide Pharmacological target (-,-) : BE0000502 Solute carrier family 12 member 1 Non-common off-target(s) (drug2) : BE0000267 Carbonic anhydrase 1 (-1) BE0000322 Carbonic anhydrase 2 (-1) BE0000535 Carbonic anhydrase 4 (-1) --------------------------------------------------- Drug1 : DB00214 Torasemide Drug2 : DB00310 Chlorthalidone Pharmacological target (-,-) : BE0000502 Solute carrier family 12 member 1 --------------------------------------------------- Drug1 : DB00214 Torasemide Drug2 : DB00695 Furosemide Pharmacological target (-,-) : BE0000502 Solute carrier family 12 member 1 --------------------------------------------------- Drug1 : DB00214 Torasemide Drug2 : DB00774 Hydroflumethiazide Pharmacological target (-,-) : BE0000502 Solute carrier family 12 member 1 Non-common off-target(s) (drug2) : BE0000267 Carbonic anhydrase 1 (-1) BE0000322 Carbonic anhydrase 2 (-1) BE0000535 Carbonic anhydrase 4 (-1) BE0002437 Carbonic anhydrase 9 (-1) BE0001653 Carbonic anhydrase 12 (-1) --------------------------------------------------- Drug1 : DB00214 Torasemide Drug2 : DB00903 Ethacrynic acid Pharmacological target (-,-) : BE0000502 Solute carrier family 12 member 1 Non-common off-target(s) (drug2) : BE0000732 Sodium/potassium-transporting ATPase subunit alpha-1 (-1) --------------------------------------------------- Drug1 : DB00214 Torasemide Drug2 : DB01021 Trichlormethiazide Pharmacological target (-,-) : BE0000502 Solute carrier family 12 member 1 Non-common off-target(s) (drug2) : BE0000267 Carbonic anhydrase 1 (-1) BE0000322 Carbonic anhydrase 2 (-1) BE0000535 Carbonic anhydrase 4 (-1) BE0000732 Sodium/potassium-transporting ATPase subunit alpha-1 (-1) --------------------------------------------------- Drug1 : DB00215 Citalopram Drug2 : DB00285 Venlafaxine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB00215 Citalopram Drug2 : DB00344 Protriptyline Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug2) : BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB00215 Citalopram Drug2 : DB00458 Imipramine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug2) : BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0003603 Potassium voltage-gated channel subfamily D member 2 (-1) BE0003604 Potassium voltage-gated channel subfamily D member 3 (-1) --------------------------------------------------- Drug1 : DB00215 Citalopram Drug2 : DB00472 Fluoxetine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter --------------------------------------------------- Drug1 : DB00215 Citalopram Drug2 : DB00476 Duloxetine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB00215 Citalopram Drug2 : DB00543 Amoxapine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug2) : BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000756 D(2) dopamine receptor (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000797 5-hydroxytryptamine receptor 1B (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0004864 Alpha-2 adrenergic receptor (-1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0004863 Alpha-1 adrenergic receptor (-1) BE0004890 Muscarinic acetylcholine receptor (-1) --------------------------------------------------- Drug1 : DB00215 Citalopram Drug2 : DB00715 Paroxetine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug2) : BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00215 Citalopram Drug2 : DB00726 Trimipramine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (1) BE0000289 Alpha-2A adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00215 Citalopram Drug2 : DB01104 Sertraline Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB00215 Citalopram Drug2 : DB01175 Escitalopram Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) --------------------------------------------------- Drug1 : DB00215 Citalopram Drug2 : DB01191 Dexfenfluramine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug2) : BE0000533 5-hydroxytryptamine receptor 2C (1) --------------------------------------------------- Drug1 : DB00215 Citalopram Drug2 : DB04896 Milnacipran Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug2) : BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0004956 NMDA receptor (-1) --------------------------------------------------- Drug1 : DB00215 Citalopram Drug2 : DB06700 Desvenlafaxine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug2) : BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB00215 Citalopram Drug2 : DB08918 Levomilnacipran Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug2) : BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB00216 Eletriptan Drug2 : DB00953 Rizatriptan Pharmacological target (+,+) : BE0000659 5-hydroxytryptamine receptor 1D Pharmacological target (+,+) : BE0000797 5-hydroxytryptamine receptor 1B Pharmacological target (+,+) : BE0000460 5-hydroxytryptamine receptor 1F Non-common off-target(s) (drug1) : BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000476 5-hydroxytryptamine receptor 1E (1) BE0000393 5-hydroxytryptamine receptor 2B (1) BE0000650 5-hydroxytryptamine receptor 7 (1) --------------------------------------------------- Drug1 : DB00216 Eletriptan Drug2 : DB00998 Frovatriptan Pharmacological target (+,+) : BE0000659 5-hydroxytryptamine receptor 1D Pharmacological target (+,+) : BE0000797 5-hydroxytryptamine receptor 1B Non-common off-target(s) (drug1) : BE0000460 5-hydroxytryptamine receptor 1F (1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000476 5-hydroxytryptamine receptor 1E (1) BE0000393 5-hydroxytryptamine receptor 2B (1) BE0000650 5-hydroxytryptamine receptor 7 (1) --------------------------------------------------- Drug1 : DB00217 Bethanidine Drug2 : DB00414 Acetohexamide Pharmacological target (-,-) : BE0000644 ATP-sensitive inward rectifier potassium channel 1 Non-common off-target(s) (drug1) : BE0004872 Beta adrenergic receptor (-1) BE0004864 Alpha-2 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00217 Bethanidine Drug2 : DB00839 Tolazamide Pharmacological target (-,-) : BE0000644 ATP-sensitive inward rectifier potassium channel 1 Non-common off-target(s) (drug1) : BE0004872 Beta adrenergic receptor (-1) BE0004864 Alpha-2 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00219 Oxyphenonium Drug2 : DB00245 Benzatropine Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0000442 Histamine H1 receptor (-1) --------------------------------------------------- Drug1 : DB00219 Oxyphenonium Drug2 : DB00354 Buclizine Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug2) : BE0000442 Histamine H1 receptor (-1) --------------------------------------------------- Drug1 : DB00219 Oxyphenonium Drug2 : DB00376 Trihexyphenidyl Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00219 Oxyphenonium Drug2 : DB00392 Ethopropazine Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug2) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00219 Oxyphenonium Drug2 : DB00424 Hyoscyamine Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) --------------------------------------------------- Drug1 : DB00219 Oxyphenonium Drug2 : DB00462 Methylscopolamine bromide Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00219 Oxyphenonium Drug2 : DB00670 Pirenzepine Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 --------------------------------------------------- Drug1 : DB00219 Oxyphenonium Drug2 : DB00747 Scopolamine Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0001176 Sucrase-isomaltase, intestinal (-1) --------------------------------------------------- Drug1 : DB00219 Oxyphenonium Drug2 : DB00771 Clidinium Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 --------------------------------------------------- Drug1 : DB00219 Oxyphenonium Drug2 : DB00782 Propantheline Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 --------------------------------------------------- Drug1 : DB00219 Oxyphenonium Drug2 : DB00804 Dicyclomine Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug2) : BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00219 Oxyphenonium Drug2 : DB00810 Biperiden Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug2) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) --------------------------------------------------- Drug1 : DB00219 Oxyphenonium Drug2 : DB00942 Cycrimine Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 --------------------------------------------------- Drug1 : DB00219 Oxyphenonium Drug2 : DB00979 Cyclopentolate Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 --------------------------------------------------- Drug1 : DB00219 Oxyphenonium Drug2 : DB00986 Glycopyrrolate Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) --------------------------------------------------- Drug1 : DB00219 Oxyphenonium Drug2 : DB01148 Flavoxate Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug2) : BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00219 Oxyphenonium Drug2 : DB04843 Mepenzolate Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) --------------------------------------------------- Drug1 : DB00223 Diflorasone Drug2 : DB00240 Alclometasone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00223 Diflorasone Drug2 : DB00253 Medrysone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00223 Diflorasone Drug2 : DB00288 Amcinonide Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug2) : BE0000422 Annexin A1 (1) --------------------------------------------------- Drug1 : DB00223 Diflorasone Drug2 : DB00324 Fluorometholone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00223 Diflorasone Drug2 : DB00394 Beclomethasone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00223 Diflorasone Drug2 : DB00443 Betamethasone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00223 Diflorasone Drug2 : DB00547 Desoximetasone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00223 Diflorasone Drug2 : DB00588 Fluticasone Propionate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug2) : BE0000557 Progesterone receptor (1) BE0000668 Mineralocorticoid receptor (-1) BE0000657 Cytosolic phospholipase A2 (-1) --------------------------------------------------- Drug1 : DB00223 Diflorasone Drug2 : DB00591 Fluocinolone Acetonide Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00223 Diflorasone Drug2 : DB00596 Halobetasol Propionate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00223 Diflorasone Drug2 : DB00620 Triamcinolone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00223 Diflorasone Drug2 : DB00635 Prednisone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00223 Diflorasone Drug2 : DB00663 Flumethasone Pivalate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00223 Diflorasone Drug2 : DB00741 Hydrocortisone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug2) : BE0000422 Annexin A1 (1) --------------------------------------------------- Drug1 : DB00223 Diflorasone Drug2 : DB00764 Mometasone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00223 Diflorasone Drug2 : DB00769 Hydrocortamate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00223 Diflorasone Drug2 : DB00838 Clocortolone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00223 Diflorasone Drug2 : DB00846 Flurandrenolide Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00223 Diflorasone Drug2 : DB00860 Prednisolone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00223 Diflorasone Drug2 : DB00873 Loteprednol Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00223 Diflorasone Drug2 : DB00896 Rimexolone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00223 Diflorasone Drug2 : DB00959 Methylprednisolone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00223 Diflorasone Drug2 : DB01013 Clobetasol propionate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00223 Diflorasone Drug2 : DB01047 Fluocinonide Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug2) : BE0004659 Smoothened homolog (1) --------------------------------------------------- Drug1 : DB00223 Diflorasone Drug2 : DB01130 Prednicarbate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00223 Diflorasone Drug2 : DB01234 Dexamethasone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug2) : BE0000005 Nitric oxide synthase, inducible (-1) BE0000422 Annexin A1 (1) BE0000074 Nuclear receptor subfamily 0 group B member 1 (1) --------------------------------------------------- Drug1 : DB00223 Diflorasone Drug2 : DB01260 Desonide Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00223 Diflorasone Drug2 : DB01380 Cortisone acetate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00223 Diflorasone Drug2 : DB01384 Paramethasone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00223 Diflorasone Drug2 : DB01410 Ciclesonide Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00223 Diflorasone Drug2 : DB06781 Difluprednate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00223 Diflorasone Drug2 : DB08906 Fluticasone furoate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00226 Guanadrel Drug2 : DB01170 Guanethidine Pharmacological target (+,+) : BE0000486 Sodium-dependent noradrenaline transporter --------------------------------------------------- Drug1 : DB00226 Guanadrel Drug2 : DB04840 Debrisoquin Pharmacological target (+,+) : BE0000486 Sodium-dependent noradrenaline transporter --------------------------------------------------- Drug1 : DB00227 Lovastatin Drug2 : DB00439 Cerivastatin Pharmacological target (-,-) : BE0000574 3-hydroxy-3-methylglutaryl-coenzyme A reductase --------------------------------------------------- Drug1 : DB00227 Lovastatin Drug2 : DB00641 Simvastatin Pharmacological target (-,-) : BE0000574 3-hydroxy-3-methylglutaryl-coenzyme A reductase --------------------------------------------------- Drug1 : DB00227 Lovastatin Drug2 : DB01076 Atorvastatin Pharmacological target (-,-) : BE0000574 3-hydroxy-3-methylglutaryl-coenzyme A reductase Non-common off-target(s) (drug2) : BE0003721 Aryl hydrocarbon receptor (1) BE0000854 Dipeptidyl peptidase 4 (-1) --------------------------------------------------- Drug1 : DB00227 Lovastatin Drug2 : DB01095 Fluvastatin Pharmacological target (-,-) : BE0000574 3-hydroxy-3-methylglutaryl-coenzyme A reductase --------------------------------------------------- Drug1 : DB00227 Lovastatin Drug2 : DB01098 Rosuvastatin Pharmacological target (-,-) : BE0000574 3-hydroxy-3-methylglutaryl-coenzyme A reductase --------------------------------------------------- Drug1 : DB00227 Lovastatin Drug2 : DB06693 Mevastatin Pharmacological target (-,-) : BE0000574 3-hydroxy-3-methylglutaryl-coenzyme A reductase --------------------------------------------------- Drug1 : DB00227 Lovastatin Drug2 : DB08860 Pitavastatin Pharmacological target (-,-) : BE0000574 3-hydroxy-3-methylglutaryl-coenzyme A reductase --------------------------------------------------- Drug1 : DB00228 Enflurane Drug2 : DB00753 Isoflurane Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000781 Potassium voltage-gated channel subfamily A member 1 Pharmacological target (-,-) : BE0000640 Glutamate receptor 1 Pharmacological target (-,-) : BE0000218 Calcium-transporting ATPase type 2C member 1 Non-common off-target(s) (drug1) : BE0004857 Glycine receptor (alpha-1/beta) (1) BE0000415 Intermediate conductance calcium-activated potassium channel protein 4 (-1) Non-common off-target(s) (drug2) : BE0000433 Glycine receptor subunit alpha-1 (1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) --------------------------------------------------- Drug1 : DB00228 Enflurane Drug2 : DB01189 Desflurane Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000781 Potassium voltage-gated channel subfamily A member 1 Pharmacological target (-,-) : BE0000640 Glutamate receptor 1 Pharmacological target (-,-) : BE0000218 Calcium-transporting ATPase type 2C member 1 Non-common off-target(s) (drug1) : BE0004857 Glycine receptor (alpha-1/beta) (1) BE0000415 Intermediate conductance calcium-activated potassium channel protein 4 (-1) Non-common off-target(s) (drug2) : BE0000433 Glycine receptor subunit alpha-1 (1) --------------------------------------------------- Drug1 : DB00228 Enflurane Drug2 : DB01236 Sevoflurane Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000781 Potassium voltage-gated channel subfamily A member 1 Pharmacological target (-,-) : BE0000640 Glutamate receptor 1 Pharmacological target (-,-) : BE0000218 Calcium-transporting ATPase type 2C member 1 Non-common off-target(s) (drug1) : BE0004857 Glycine receptor (alpha-1/beta) (1) BE0000415 Intermediate conductance calcium-activated potassium channel protein 4 (-1) Non-common off-target(s) (drug2) : BE0000433 Glycine receptor subunit alpha-1 (1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) --------------------------------------------------- Drug1 : DB00231 Temazepam Drug2 : DB00546 Adinazolam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Pharmacological target (+,+) : BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Pharmacological target (+,+) : BE0003596 Gamma-aminobutyric acid receptor subunit pi Pharmacological target (+,+) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Pharmacological target (+,+) : BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 Pharmacological target (+,+) : BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00231 Temazepam Drug2 : DB00683 Midazolam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Pharmacological target (+,+) : BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Pharmacological target (+,+) : BE0003596 Gamma-aminobutyric acid receptor subunit pi Pharmacological target (+,+) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Pharmacological target (+,+) : BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 Pharmacological target (+,+) : BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 Pharmacological target (+,+) : BE0003597 Gamma-aminobutyric acid receptor subunit theta Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) --------------------------------------------------- Drug1 : DB00231 Temazepam Drug2 : DB00690 Flurazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Pharmacological target (+,+) : BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Pharmacological target (+,+) : BE0003596 Gamma-aminobutyric acid receptor subunit pi Pharmacological target (+,+) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Pharmacological target (+,+) : BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 Pharmacological target (+,+) : BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 Pharmacological target (+,+) : BE0003597 Gamma-aminobutyric acid receptor subunit theta Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) --------------------------------------------------- Drug1 : DB00231 Temazepam Drug2 : DB00801 Halazepam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Pharmacological target (+,+) : BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Pharmacological target (+,+) : BE0003596 Gamma-aminobutyric acid receptor subunit pi Pharmacological target (+,+) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Pharmacological target (+,+) : BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 Pharmacological target (+,+) : BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 Non-common off-target(s) (drug1) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00231 Temazepam Drug2 : DB00829 Diazepam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Pharmacological target (+,+) : BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Pharmacological target (+,+) : BE0003596 Gamma-aminobutyric acid receptor subunit pi Pharmacological target (+,+) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Pharmacological target (+,+) : BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 Pharmacological target (+,+) : BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 Pharmacological target (+,+) : BE0003597 Gamma-aminobutyric acid receptor subunit theta Non-common off-target(s) (drug1) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0000736 Translocator protein (1) --------------------------------------------------- Drug1 : DB00231 Temazepam Drug2 : DB00842 Oxazepam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Pharmacological target (+,+) : BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Pharmacological target (+,+) : BE0003596 Gamma-aminobutyric acid receptor subunit pi Pharmacological target (+,+) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Pharmacological target (+,+) : BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 Pharmacological target (+,+) : BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 Pharmacological target (+,+) : BE0003597 Gamma-aminobutyric acid receptor subunit theta --------------------------------------------------- Drug1 : DB00231 Temazepam Drug2 : DB00897 Triazolam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Pharmacological target (+,+) : BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Pharmacological target (+,+) : BE0003596 Gamma-aminobutyric acid receptor subunit pi Pharmacological target (+,+) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Pharmacological target (+,+) : BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 Pharmacological target (+,+) : BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 Pharmacological target (+,+) : BE0003597 Gamma-aminobutyric acid receptor subunit theta --------------------------------------------------- Drug1 : DB00231 Temazepam Drug2 : DB01215 Estazolam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Pharmacological target (+,+) : BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Pharmacological target (+,+) : BE0003596 Gamma-aminobutyric acid receptor subunit pi Pharmacological target (+,+) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Pharmacological target (+,+) : BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 Pharmacological target (+,+) : BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 Non-common off-target(s) (drug1) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00231 Temazepam Drug2 : DB01558 Bromazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Pharmacological target (+,+) : BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Pharmacological target (+,+) : BE0003596 Gamma-aminobutyric acid receptor subunit pi Pharmacological target (+,+) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Pharmacological target (+,+) : BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 Pharmacological target (+,+) : BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 Pharmacological target (+,+) : BE0003597 Gamma-aminobutyric acid receptor subunit theta Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) --------------------------------------------------- Drug1 : DB00231 Temazepam Drug2 : DB01559 Clotiazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Pharmacological target (+,+) : BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Pharmacological target (+,+) : BE0003596 Gamma-aminobutyric acid receptor subunit pi Pharmacological target (+,+) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Pharmacological target (+,+) : BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 Pharmacological target (+,+) : BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00231 Temazepam Drug2 : DB01567 Fludiazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Pharmacological target (+,+) : BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Pharmacological target (+,+) : BE0003596 Gamma-aminobutyric acid receptor subunit pi Pharmacological target (+,+) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Pharmacological target (+,+) : BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 Pharmacological target (+,+) : BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00231 Temazepam Drug2 : DB01588 Prazepam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Pharmacological target (+,+) : BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Pharmacological target (+,+) : BE0003596 Gamma-aminobutyric acid receptor subunit pi Pharmacological target (+,+) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Pharmacological target (+,+) : BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 Pharmacological target (+,+) : BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 Non-common off-target(s) (drug1) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00231 Temazepam Drug2 : DB01589 Quazepam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Pharmacological target (+,+) : BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Pharmacological target (+,+) : BE0003596 Gamma-aminobutyric acid receptor subunit pi Pharmacological target (+,+) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Pharmacological target (+,+) : BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 Pharmacological target (+,+) : BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 Non-common off-target(s) (drug1) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00231 Temazepam Drug2 : DB01594 Cinolazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Pharmacological target (+,+) : BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Pharmacological target (+,+) : BE0003596 Gamma-aminobutyric acid receptor subunit pi Pharmacological target (+,+) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Pharmacological target (+,+) : BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 Pharmacological target (+,+) : BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00231 Temazepam Drug2 : DB01595 Nitrazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Pharmacological target (+,+) : BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Pharmacological target (+,+) : BE0003596 Gamma-aminobutyric acid receptor subunit pi Pharmacological target (+,+) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Pharmacological target (+,+) : BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 Pharmacological target (+,+) : BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 Pharmacological target (+,+) : BE0003597 Gamma-aminobutyric acid receptor subunit theta Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) --------------------------------------------------- Drug1 : DB00232 Methyclothiazide Drug2 : DB00310 Chlorthalidone Pharmacological target (-,-) : BE0000502 Solute carrier family 12 member 1 Non-common off-target(s) (drug1) : BE0000267 Carbonic anhydrase 1 (-1) BE0000322 Carbonic anhydrase 2 (-1) BE0000535 Carbonic anhydrase 4 (-1) --------------------------------------------------- Drug1 : DB00232 Methyclothiazide Drug2 : DB00695 Furosemide Pharmacological target (-,-) : BE0000502 Solute carrier family 12 member 1 Non-common off-target(s) (drug1) : BE0000267 Carbonic anhydrase 1 (-1) BE0000322 Carbonic anhydrase 2 (-1) BE0000535 Carbonic anhydrase 4 (-1) --------------------------------------------------- Drug1 : DB00232 Methyclothiazide Drug2 : DB00903 Ethacrynic acid Pharmacological target (-,-) : BE0000502 Solute carrier family 12 member 1 Non-common off-target(s) (drug1) : BE0000267 Carbonic anhydrase 1 (-1) BE0000322 Carbonic anhydrase 2 (-1) BE0000535 Carbonic anhydrase 4 (-1) Non-common off-target(s) (drug2) : BE0000732 Sodium/potassium-transporting ATPase subunit alpha-1 (-1) --------------------------------------------------- Drug1 : DB00234 Reboxetine Drug2 : DB00285 Venlafaxine Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB00234 Reboxetine Drug2 : DB00344 Protriptyline Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) --------------------------------------------------- Drug1 : DB00234 Reboxetine Drug2 : DB00458 Imipramine Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0003603 Potassium voltage-gated channel subfamily D member 2 (-1) BE0003604 Potassium voltage-gated channel subfamily D member 3 (-1) --------------------------------------------------- Drug1 : DB00234 Reboxetine Drug2 : DB00476 Duloxetine Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB00234 Reboxetine Drug2 : DB00726 Trimipramine Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (1) BE0000289 Alpha-2A adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00234 Reboxetine Drug2 : DB00830 Phenmetrazine Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB00234 Reboxetine Drug2 : DB00934 Maprotiline Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000442 Histamine H1 receptor (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0004864 Alpha-2 adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0004863 Alpha-1 adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00234 Reboxetine Drug2 : DB00937 Diethylpropion Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB00234 Reboxetine Drug2 : DB01156 Bupropion Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0003585 Neuronal acetylcholine receptor subunit alpha-3 (-1) --------------------------------------------------- Drug1 : DB00234 Reboxetine Drug2 : DB01579 Phendimetrazine Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00234 Reboxetine Drug2 : DB04896 Milnacipran Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0004956 NMDA receptor (-1) --------------------------------------------------- Drug1 : DB00234 Reboxetine Drug2 : DB06204 Tapentadol Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000770 Mu-type opioid receptor (1) --------------------------------------------------- Drug1 : DB00234 Reboxetine Drug2 : DB06700 Desvenlafaxine Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) --------------------------------------------------- Drug1 : DB00234 Reboxetine Drug2 : DB06701 Dexmethylphenidate Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB00234 Reboxetine Drug2 : DB08918 Levomilnacipran Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) --------------------------------------------------- Drug1 : DB00235 Milrinone Drug2 : DB00261 Anagrelide Pharmacological target (-,-) : BE0000436 cGMP-inhibited 3',5'-cyclic phosphodiesterase A --------------------------------------------------- Drug1 : DB00235 Milrinone Drug2 : DB01166 Cilostazol Pharmacological target (-,-) : BE0000436 cGMP-inhibited 3',5'-cyclic phosphodiesterase A --------------------------------------------------- Drug1 : DB00235 Milrinone Drug2 : DB01427 Amrinone Pharmacological target (-,-) : BE0000436 cGMP-inhibited 3',5'-cyclic phosphodiesterase A Non-common off-target(s) (drug2) : BE0000704 Tumor necrosis factor (-1) BE0000487 cAMP-specific 3',5'-cyclic phosphodiesterase 4B (-1) --------------------------------------------------- Drug1 : DB00235 Milrinone Drug2 : DB04880 Enoximone Pharmacological target (-,-) : BE0000436 cGMP-inhibited 3',5'-cyclic phosphodiesterase A --------------------------------------------------- Drug1 : DB00237 Butabarbital Drug2 : DB00349 Clobazam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) --------------------------------------------------- Drug1 : DB00237 Butabarbital Drug2 : DB00404 Alprazolam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) --------------------------------------------------- Drug1 : DB00237 Butabarbital Drug2 : DB00475 Chlordiazepoxide Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) --------------------------------------------------- Drug1 : DB00237 Butabarbital Drug2 : DB00628 Clorazepate Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) Non-common off-target(s) (drug2) : BE0000736 Translocator protein (1) --------------------------------------------------- Drug1 : DB00237 Butabarbital Drug2 : DB01068 Clonazepam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) --------------------------------------------------- Drug1 : DB00237 Butabarbital Drug2 : DB01107 Methyprylon Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) Non-common off-target(s) (drug2) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) --------------------------------------------------- Drug1 : DB00237 Butabarbital Drug2 : DB01159 Halothane Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) Non-common off-target(s) (drug2) : BE0000534 Glutamate receptor ionotropic, NMDA 3B (-1) BE0000760 Glutamate receptor ionotropic, NMDA 2A (-1) BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000503 NADH-ubiquinone oxidoreductase chain 1 (-1) BE0000415 Intermediate conductance calcium-activated potassium channel protein 4 (-1) BE0000553 Calcium-activated potassium channel subunit alpha-1 (-1) BE0001028 G protein-activated inward rectifier potassium channel 1 (-1) BE0001030 G protein-activated inward rectifier potassium channel 2 (-1) --------------------------------------------------- Drug1 : DB00237 Butabarbital Drug2 : DB01437 Glutethimide Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) Non-common off-target(s) (drug2) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) --------------------------------------------------- Drug1 : DB00240 Alclometasone Drug2 : DB00253 Medrysone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00240 Alclometasone Drug2 : DB00288 Amcinonide Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug2) : BE0000422 Annexin A1 (1) --------------------------------------------------- Drug1 : DB00240 Alclometasone Drug2 : DB00324 Fluorometholone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00240 Alclometasone Drug2 : DB00394 Beclomethasone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00240 Alclometasone Drug2 : DB00443 Betamethasone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00240 Alclometasone Drug2 : DB00547 Desoximetasone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00240 Alclometasone Drug2 : DB00588 Fluticasone Propionate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug2) : BE0000557 Progesterone receptor (1) BE0000668 Mineralocorticoid receptor (-1) BE0000657 Cytosolic phospholipase A2 (-1) --------------------------------------------------- Drug1 : DB00240 Alclometasone Drug2 : DB00591 Fluocinolone Acetonide Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00240 Alclometasone Drug2 : DB00596 Halobetasol Propionate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00240 Alclometasone Drug2 : DB00620 Triamcinolone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00240 Alclometasone Drug2 : DB00635 Prednisone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00240 Alclometasone Drug2 : DB00663 Flumethasone Pivalate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00240 Alclometasone Drug2 : DB00741 Hydrocortisone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug2) : BE0000422 Annexin A1 (1) --------------------------------------------------- Drug1 : DB00240 Alclometasone Drug2 : DB00764 Mometasone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00240 Alclometasone Drug2 : DB00769 Hydrocortamate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00240 Alclometasone Drug2 : DB00838 Clocortolone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00240 Alclometasone Drug2 : DB00846 Flurandrenolide Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00240 Alclometasone Drug2 : DB00860 Prednisolone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00240 Alclometasone Drug2 : DB00873 Loteprednol Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00240 Alclometasone Drug2 : DB00896 Rimexolone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00240 Alclometasone Drug2 : DB00959 Methylprednisolone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00240 Alclometasone Drug2 : DB01013 Clobetasol propionate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00240 Alclometasone Drug2 : DB01047 Fluocinonide Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug2) : BE0004659 Smoothened homolog (1) --------------------------------------------------- Drug1 : DB00240 Alclometasone Drug2 : DB01130 Prednicarbate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00240 Alclometasone Drug2 : DB01234 Dexamethasone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug2) : BE0000005 Nitric oxide synthase, inducible (-1) BE0000422 Annexin A1 (1) BE0000074 Nuclear receptor subfamily 0 group B member 1 (1) --------------------------------------------------- Drug1 : DB00240 Alclometasone Drug2 : DB01260 Desonide Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00240 Alclometasone Drug2 : DB01380 Cortisone acetate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00240 Alclometasone Drug2 : DB01384 Paramethasone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00240 Alclometasone Drug2 : DB01410 Ciclesonide Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00240 Alclometasone Drug2 : DB06781 Difluprednate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00240 Alclometasone Drug2 : DB08906 Fluticasone furoate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00241 Butalbital Drug2 : DB00371 Meprobamate Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) --------------------------------------------------- Drug1 : DB00241 Butalbital Drug2 : DB01198 Zopiclone Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0004797 GABA-A receptor (anion channel) (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0000736 Translocator protein (1) --------------------------------------------------- Drug1 : DB00241 Butalbital Drug2 : DB01544 Flunitrazepam Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0004797 GABA-A receptor (anion channel) (1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) Non-common off-target(s) (drug2) : BE0000736 Translocator protein (1) --------------------------------------------------- Drug1 : DB00243 Ranolazine Drug2 : DB00252 Phenytoin Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0001143 Sodium channel protein type 9 subunit alpha (-1) Non-common off-target(s) (drug2) : BE0000141 Sodium channel protein type 1 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00243 Ranolazine Drug2 : DB00280 Disopyramide Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0001143 Sodium channel protein type 9 subunit alpha (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0003603 Potassium voltage-gated channel subfamily D member 2 (-1) BE0003604 Potassium voltage-gated channel subfamily D member 3 (-1) --------------------------------------------------- Drug1 : DB00243 Ranolazine Drug2 : DB00379 Mexiletine Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0001143 Sodium channel protein type 9 subunit alpha (-1) Non-common off-target(s) (drug2) : BE0003721 Aryl hydrocarbon receptor (1) --------------------------------------------------- Drug1 : DB00243 Ranolazine Drug2 : DB00473 Hexylcaine Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0001143 Sodium channel protein type 9 subunit alpha (-1) Non-common off-target(s) (drug2) : BE0000177 Sodium channel protein type 10 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00243 Ranolazine Drug2 : DB00527 Cinchocaine Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0001143 Sodium channel protein type 9 subunit alpha (-1) Non-common off-target(s) (drug2) : BE0000177 Sodium channel protein type 10 subunit alpha (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00243 Ranolazine Drug2 : DB00532 Mephenytoin Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0001143 Sodium channel protein type 9 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00243 Ranolazine Drug2 : DB00564 Carbamazepine Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0001143 Sodium channel protein type 9 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00243 Ranolazine Drug2 : DB00680 Moricizine Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0001143 Sodium channel protein type 9 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00243 Ranolazine Drug2 : DB00740 Riluzole Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0001143 Sodium channel protein type 9 subunit alpha (-1) Non-common off-target(s) (drug2) : BE0000030 Cystine/glutamate transporter (1) --------------------------------------------------- Drug1 : DB00243 Ranolazine Drug2 : DB00750 Prilocaine Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0001143 Sodium channel protein type 9 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00243 Ranolazine Drug2 : DB00754 Ethotoin Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0001143 Sodium channel protein type 9 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00243 Ranolazine Drug2 : DB00776 Oxcarbazepine Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0001143 Sodium channel protein type 9 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00243 Ranolazine Drug2 : DB00908 Quinidine Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0001143 Sodium channel protein type 9 subunit alpha (-1) Non-common off-target(s) (drug2) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000154 Potassium channel subfamily K member 1 (-1) BE0000680 Potassium channel subfamily K member 6 (-1) --------------------------------------------------- Drug1 : DB00243 Ranolazine Drug2 : DB01056 Tocainide Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0001143 Sodium channel protein type 9 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00243 Ranolazine Drug2 : DB01182 Propafenone Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0001143 Sodium channel protein type 9 subunit alpha (-1) Non-common off-target(s) (drug2) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) --------------------------------------------------- Drug1 : DB00243 Ranolazine Drug2 : DB01195 Flecainide Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0001143 Sodium channel protein type 9 subunit alpha (-1) Non-common off-target(s) (drug2) : BE0002083 Sodium channel protein type 4 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00243 Ranolazine Drug2 : DB01228 Encainide Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0001143 Sodium channel protein type 9 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00243 Ranolazine Drug2 : DB01320 Fosphenytoin Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0001143 Sodium channel protein type 9 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00243 Ranolazine Drug2 : DB01426 Ajmaline Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0001143 Sodium channel protein type 9 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00243 Ranolazine Drug2 : DB01429 Aprindine Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0001143 Sodium channel protein type 9 subunit alpha (-1) Non-common off-target(s) (drug2) : BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00244 Mesalazine Drug2 : DB00316 Acetaminophen Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0000248 Arachidonate 5-lipoxygenase (-1) BE0004655 Inhibitor of nuclear factor kappa-B kinase subunit alpha (-1) BE0001154 Inhibitor of nuclear factor kappa-B kinase subunit beta (-1) --------------------------------------------------- Drug1 : DB00244 Mesalazine Drug2 : DB00788 Naproxen Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0000248 Arachidonate 5-lipoxygenase (-1) BE0004655 Inhibitor of nuclear factor kappa-B kinase subunit alpha (-1) BE0001154 Inhibitor of nuclear factor kappa-B kinase subunit beta (-1) --------------------------------------------------- Drug1 : DB00244 Mesalazine Drug2 : DB00812 Phenylbutazone Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0000248 Arachidonate 5-lipoxygenase (-1) BE0004655 Inhibitor of nuclear factor kappa-B kinase subunit alpha (-1) BE0001154 Inhibitor of nuclear factor kappa-B kinase subunit beta (-1) Non-common off-target(s) (drug2) : BE0000117 Prostacyclin synthase (-1) --------------------------------------------------- Drug1 : DB00244 Mesalazine Drug2 : DB00870 Suprofen Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0000248 Arachidonate 5-lipoxygenase (-1) BE0004655 Inhibitor of nuclear factor kappa-B kinase subunit alpha (-1) BE0001154 Inhibitor of nuclear factor kappa-B kinase subunit beta (-1) --------------------------------------------------- Drug1 : DB00244 Mesalazine Drug2 : DB00936 Salicylic acid Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0000248 Arachidonate 5-lipoxygenase (-1) BE0004655 Inhibitor of nuclear factor kappa-B kinase subunit alpha (-1) BE0001154 Inhibitor of nuclear factor kappa-B kinase subunit beta (-1) Non-common off-target(s) (drug2) : BE0000126 Aldo-keto reductase family 1 member C1 (-1) --------------------------------------------------- Drug1 : DB00244 Mesalazine Drug2 : DB00939 Meclofenamic acid Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Pharmacological target (-,-) : BE0000248 Arachidonate 5-lipoxygenase Non-common off-target(s) (drug1) : BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0004655 Inhibitor of nuclear factor kappa-B kinase subunit alpha (-1) BE0001154 Inhibitor of nuclear factor kappa-B kinase subunit beta (-1) --------------------------------------------------- Drug1 : DB00244 Mesalazine Drug2 : DB00945 Acetylsalicylic acid Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0000248 Arachidonate 5-lipoxygenase (-1) BE0004655 Inhibitor of nuclear factor kappa-B kinase subunit alpha (-1) BE0001154 Inhibitor of nuclear factor kappa-B kinase subunit beta (-1) Non-common off-target(s) (drug2) : BE0000126 Aldo-keto reductase family 1 member C1 (-1) BE0004907 5'-AMP-activated protein kinase (1) BE0004903 Nuclear factor NF-kappa-B (-1) --------------------------------------------------- Drug1 : DB00244 Mesalazine Drug2 : DB00991 Oxaprozin Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0000248 Arachidonate 5-lipoxygenase (-1) BE0004655 Inhibitor of nuclear factor kappa-B kinase subunit alpha (-1) BE0001154 Inhibitor of nuclear factor kappa-B kinase subunit beta (-1) --------------------------------------------------- Drug1 : DB00244 Mesalazine Drug2 : DB01014 Balsalazide Pharmacological target (+,+) : BE0000215 Peroxisome proliferator-activated receptor gamma Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Pharmacological target (-,-) : BE0000248 Arachidonate 5-lipoxygenase Non-common off-target(s) (drug1) : BE0004655 Inhibitor of nuclear factor kappa-B kinase subunit alpha (-1) BE0001154 Inhibitor of nuclear factor kappa-B kinase subunit beta (-1) --------------------------------------------------- Drug1 : DB00244 Mesalazine Drug2 : DB01283 Lumiracoxib Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0000248 Arachidonate 5-lipoxygenase (-1) BE0004655 Inhibitor of nuclear factor kappa-B kinase subunit alpha (-1) BE0001154 Inhibitor of nuclear factor kappa-B kinase subunit beta (-1) --------------------------------------------------- Drug1 : DB00244 Mesalazine Drug2 : DB01397 Magnesium salicylate Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0000248 Arachidonate 5-lipoxygenase (-1) BE0004655 Inhibitor of nuclear factor kappa-B kinase subunit alpha (-1) BE0001154 Inhibitor of nuclear factor kappa-B kinase subunit beta (-1) --------------------------------------------------- Drug1 : DB00244 Mesalazine Drug2 : DB01398 Salicylate-sodium Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0000248 Arachidonate 5-lipoxygenase (-1) BE0004655 Inhibitor of nuclear factor kappa-B kinase subunit alpha (-1) BE0001154 Inhibitor of nuclear factor kappa-B kinase subunit beta (-1) --------------------------------------------------- Drug1 : DB00244 Mesalazine Drug2 : DB01399 Salsalate Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0000248 Arachidonate 5-lipoxygenase (-1) BE0004655 Inhibitor of nuclear factor kappa-B kinase subunit alpha (-1) BE0001154 Inhibitor of nuclear factor kappa-B kinase subunit beta (-1) --------------------------------------------------- Drug1 : DB00244 Mesalazine Drug2 : DB01600 Tiaprofenic acid Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0000248 Arachidonate 5-lipoxygenase (-1) BE0004655 Inhibitor of nuclear factor kappa-B kinase subunit alpha (-1) BE0001154 Inhibitor of nuclear factor kappa-B kinase subunit beta (-1) --------------------------------------------------- Drug1 : DB00244 Mesalazine Drug2 : DB06725 Lornoxicam Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0000248 Arachidonate 5-lipoxygenase (-1) BE0004655 Inhibitor of nuclear factor kappa-B kinase subunit alpha (-1) BE0001154 Inhibitor of nuclear factor kappa-B kinase subunit beta (-1) --------------------------------------------------- Drug1 : DB00245 Benzatropine Drug2 : DB00376 Trihexyphenidyl Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0000442 Histamine H1 receptor (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00245 Benzatropine Drug2 : DB00392 Ethopropazine Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0000442 Histamine H1 receptor (-1) Non-common off-target(s) (drug2) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00245 Benzatropine Drug2 : DB00422 Methylphenidate Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000442 Histamine H1 receptor (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB00245 Benzatropine Drug2 : DB00424 Hyoscyamine Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0000442 Histamine H1 receptor (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) --------------------------------------------------- Drug1 : DB00245 Benzatropine Drug2 : DB00462 Methylscopolamine bromide Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0000442 Histamine H1 receptor (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00245 Benzatropine Drug2 : DB00670 Pirenzepine Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0000442 Histamine H1 receptor (-1) --------------------------------------------------- Drug1 : DB00245 Benzatropine Drug2 : DB00745 Modafinil Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000442 Histamine H1 receptor (-1) Non-common off-target(s) (drug2) : BE0000575 Alpha-1B adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00245 Benzatropine Drug2 : DB00747 Scopolamine Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0000442 Histamine H1 receptor (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0001176 Sucrase-isomaltase, intestinal (-1) --------------------------------------------------- Drug1 : DB00245 Benzatropine Drug2 : DB00771 Clidinium Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0000442 Histamine H1 receptor (-1) --------------------------------------------------- Drug1 : DB00245 Benzatropine Drug2 : DB00782 Propantheline Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0000442 Histamine H1 receptor (-1) --------------------------------------------------- Drug1 : DB00245 Benzatropine Drug2 : DB00804 Dicyclomine Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0000442 Histamine H1 receptor (-1) Non-common off-target(s) (drug2) : BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00245 Benzatropine Drug2 : DB00810 Biperiden Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0000442 Histamine H1 receptor (-1) Non-common off-target(s) (drug2) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) --------------------------------------------------- Drug1 : DB00245 Benzatropine Drug2 : DB00830 Phenmetrazine Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000442 Histamine H1 receptor (-1) Non-common off-target(s) (drug2) : BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB00245 Benzatropine Drug2 : DB00937 Diethylpropion Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000442 Histamine H1 receptor (-1) Non-common off-target(s) (drug2) : BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB00245 Benzatropine Drug2 : DB00942 Cycrimine Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0000442 Histamine H1 receptor (-1) --------------------------------------------------- Drug1 : DB00245 Benzatropine Drug2 : DB00979 Cyclopentolate Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0000442 Histamine H1 receptor (-1) --------------------------------------------------- Drug1 : DB00245 Benzatropine Drug2 : DB00986 Glycopyrrolate Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0000442 Histamine H1 receptor (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) --------------------------------------------------- Drug1 : DB00245 Benzatropine Drug2 : DB01148 Flavoxate Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0000442 Histamine H1 receptor (-1) Non-common off-target(s) (drug2) : BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00245 Benzatropine Drug2 : DB01156 Bupropion Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000442 Histamine H1 receptor (-1) Non-common off-target(s) (drug2) : BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0003585 Neuronal acetylcholine receptor subunit alpha-3 (-1) --------------------------------------------------- Drug1 : DB00245 Benzatropine Drug2 : DB01255 Lisdexamfetamine Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000442 Histamine H1 receptor (-1) Non-common off-target(s) (drug2) : BE0000575 Alpha-1B adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00245 Benzatropine Drug2 : DB01463 Fencamfamine Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000442 Histamine H1 receptor (-1) --------------------------------------------------- Drug1 : DB00245 Benzatropine Drug2 : DB04843 Mepenzolate Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0000442 Histamine H1 receptor (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) --------------------------------------------------- Drug1 : DB00245 Benzatropine Drug2 : DB06701 Dexmethylphenidate Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000442 Histamine H1 receptor (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB00246 Ziprasidone Drug2 : DB00433 Prochlorperazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000659 5-hydroxytryptamine receptor 1D (-1) BE0000797 5-hydroxytryptamine receptor 1B (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000476 5-hydroxytryptamine receptor 1E (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000145 D(1B) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00246 Ziprasidone Drug2 : DB00924 Cyclobenzaprine Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000659 5-hydroxytryptamine receptor 1D (-1) BE0000797 5-hydroxytryptamine receptor 1B (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000476 5-hydroxytryptamine receptor 1E (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000145 D(1B) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00246 Ziprasidone Drug2 : DB00933 Mesoridazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000659 5-hydroxytryptamine receptor 1D (-1) BE0000797 5-hydroxytryptamine receptor 1B (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000476 5-hydroxytryptamine receptor 1E (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000145 D(1B) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00246 Ziprasidone Drug2 : DB01425 Alizapride Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000659 5-hydroxytryptamine receptor 1D (-1) BE0000797 5-hydroxytryptamine receptor 1B (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000476 5-hydroxytryptamine receptor 1E (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000145 D(1B) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00246 Ziprasidone Drug2 : DB09018 Bromopride Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000659 5-hydroxytryptamine receptor 1D (-1) BE0000797 5-hydroxytryptamine receptor 1B (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000476 5-hydroxytryptamine receptor 1E (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000145 D(1B) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00247 Methysergide Drug2 : DB00805 Minaprine Pharmacological target (-,-) : BE0000533 5-hydroxytryptamine receptor 2C Pharmacological target (-,-) : BE0000393 5-hydroxytryptamine receptor 2B Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000650 5-hydroxytryptamine receptor 7 (-1) Non-common off-target(s) (drug2) : BE0000426 Acetylcholinesterase (-1) BE0000749 Sodium-dependent serotonin transporter (-1) BE0000756 D(2) dopamine receptor (1) BE0000092 Muscarinic acetylcholine receptor M1 (1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000020 D(1A) dopamine receptor (1) --------------------------------------------------- Drug1 : DB00247 Methysergide Drug2 : DB01239 Chlorprothixene Pharmacological target (-,-) : BE0000533 5-hydroxytryptamine receptor 2C Pharmacological target (-,-) : BE0000393 5-hydroxytryptamine receptor 2B Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000650 5-hydroxytryptamine receptor 7 (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000442 Histamine H1 receptor (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00247 Methysergide Drug2 : DB01242 Clomipramine Pharmacological target (-,-) : BE0000533 5-hydroxytryptamine receptor 2C Pharmacological target (-,-) : BE0000393 5-hydroxytryptamine receptor 2B Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000650 5-hydroxytryptamine receptor 7 (-1) Non-common off-target(s) (drug2) : BE0000814 Glutathione S-transferase P (-1) BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB00248 Cabergoline Drug2 : DB00915 Amantadine Pharmacological target (+,+) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (1) BE0000659 5-hydroxytryptamine receptor 1D (1) BE0000797 5-hydroxytryptamine receptor 1B (1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000393 5-hydroxytryptamine receptor 2B (1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (1) BE0000020 D(1A) dopamine receptor (1) BE0000145 D(1B) dopamine receptor (1) BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0004889 D(1) dopamine receptor (1) BE0004916 D(2S) dopamine receptor (1) BE0004915 D(2L) dopamine receptor (1) Non-common off-target(s) (drug2) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) --------------------------------------------------- Drug1 : DB00252 Phenytoin Drug2 : DB00280 Disopyramide Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0000141 Sodium channel protein type 1 subunit alpha (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0003603 Potassium voltage-gated channel subfamily D member 2 (-1) BE0003604 Potassium voltage-gated channel subfamily D member 3 (-1) --------------------------------------------------- Drug1 : DB00252 Phenytoin Drug2 : DB00379 Mexiletine Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0000141 Sodium channel protein type 1 subunit alpha (-1) Non-common off-target(s) (drug2) : BE0003721 Aryl hydrocarbon receptor (1) --------------------------------------------------- Drug1 : DB00252 Phenytoin Drug2 : DB00473 Hexylcaine Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0000141 Sodium channel protein type 1 subunit alpha (-1) Non-common off-target(s) (drug2) : BE0000177 Sodium channel protein type 10 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00252 Phenytoin Drug2 : DB00527 Cinchocaine Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0000141 Sodium channel protein type 1 subunit alpha (-1) Non-common off-target(s) (drug2) : BE0000177 Sodium channel protein type 10 subunit alpha (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00252 Phenytoin Drug2 : DB00532 Mephenytoin Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0000141 Sodium channel protein type 1 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00252 Phenytoin Drug2 : DB00564 Carbamazepine Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0000141 Sodium channel protein type 1 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00252 Phenytoin Drug2 : DB00680 Moricizine Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0000141 Sodium channel protein type 1 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00252 Phenytoin Drug2 : DB00740 Riluzole Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0000141 Sodium channel protein type 1 subunit alpha (-1) Non-common off-target(s) (drug2) : BE0000030 Cystine/glutamate transporter (1) --------------------------------------------------- Drug1 : DB00252 Phenytoin Drug2 : DB00750 Prilocaine Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0000141 Sodium channel protein type 1 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00252 Phenytoin Drug2 : DB00754 Ethotoin Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0000141 Sodium channel protein type 1 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00252 Phenytoin Drug2 : DB00776 Oxcarbazepine Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0000141 Sodium channel protein type 1 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00252 Phenytoin Drug2 : DB00908 Quinidine Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0000141 Sodium channel protein type 1 subunit alpha (-1) Non-common off-target(s) (drug2) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000154 Potassium channel subfamily K member 1 (-1) BE0000680 Potassium channel subfamily K member 6 (-1) --------------------------------------------------- Drug1 : DB00252 Phenytoin Drug2 : DB01056 Tocainide Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0000141 Sodium channel protein type 1 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00252 Phenytoin Drug2 : DB01121 Phenacemide Pharmacological target (-,-) : BE0000141 Sodium channel protein type 1 subunit alpha Non-common off-target(s) (drug1) : BE0000197 Sodium channel protein type 5 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00252 Phenytoin Drug2 : DB01182 Propafenone Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0000141 Sodium channel protein type 1 subunit alpha (-1) Non-common off-target(s) (drug2) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) --------------------------------------------------- Drug1 : DB00252 Phenytoin Drug2 : DB01195 Flecainide Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0000141 Sodium channel protein type 1 subunit alpha (-1) Non-common off-target(s) (drug2) : BE0002083 Sodium channel protein type 4 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00252 Phenytoin Drug2 : DB01228 Encainide Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0000141 Sodium channel protein type 1 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00252 Phenytoin Drug2 : DB01320 Fosphenytoin Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0000141 Sodium channel protein type 1 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00252 Phenytoin Drug2 : DB01426 Ajmaline Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0000141 Sodium channel protein type 1 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00252 Phenytoin Drug2 : DB01429 Aprindine Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0000141 Sodium channel protein type 1 subunit alpha (-1) Non-common off-target(s) (drug2) : BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00252 Phenytoin Drug2 : DB01438 Phenazopyridine Pharmacological target (-,-) : BE0000141 Sodium channel protein type 1 subunit alpha Non-common off-target(s) (drug1) : BE0000197 Sodium channel protein type 5 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00252 Phenytoin Drug2 : DB04930 Permethrin Pharmacological target (-,-) : BE0000141 Sodium channel protein type 1 subunit alpha Non-common off-target(s) (drug1) : BE0000197 Sodium channel protein type 5 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00253 Medrysone Drug2 : DB00288 Amcinonide Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug2) : BE0000422 Annexin A1 (1) --------------------------------------------------- Drug1 : DB00253 Medrysone Drug2 : DB00324 Fluorometholone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00253 Medrysone Drug2 : DB00394 Beclomethasone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00253 Medrysone Drug2 : DB00443 Betamethasone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00253 Medrysone Drug2 : DB00547 Desoximetasone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00253 Medrysone Drug2 : DB00588 Fluticasone Propionate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug2) : BE0000557 Progesterone receptor (1) BE0000668 Mineralocorticoid receptor (-1) BE0000657 Cytosolic phospholipase A2 (-1) --------------------------------------------------- Drug1 : DB00253 Medrysone Drug2 : DB00591 Fluocinolone Acetonide Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00253 Medrysone Drug2 : DB00596 Halobetasol Propionate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00253 Medrysone Drug2 : DB00620 Triamcinolone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00253 Medrysone Drug2 : DB00635 Prednisone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00253 Medrysone Drug2 : DB00663 Flumethasone Pivalate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00253 Medrysone Drug2 : DB00741 Hydrocortisone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug2) : BE0000422 Annexin A1 (1) --------------------------------------------------- Drug1 : DB00253 Medrysone Drug2 : DB00764 Mometasone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00253 Medrysone Drug2 : DB00769 Hydrocortamate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00253 Medrysone Drug2 : DB00838 Clocortolone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00253 Medrysone Drug2 : DB00846 Flurandrenolide Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00253 Medrysone Drug2 : DB00860 Prednisolone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00253 Medrysone Drug2 : DB00873 Loteprednol Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00253 Medrysone Drug2 : DB00896 Rimexolone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00253 Medrysone Drug2 : DB00959 Methylprednisolone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00253 Medrysone Drug2 : DB01013 Clobetasol propionate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00253 Medrysone Drug2 : DB01047 Fluocinonide Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug2) : BE0004659 Smoothened homolog (1) --------------------------------------------------- Drug1 : DB00253 Medrysone Drug2 : DB01130 Prednicarbate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00253 Medrysone Drug2 : DB01234 Dexamethasone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug2) : BE0000005 Nitric oxide synthase, inducible (-1) BE0000422 Annexin A1 (1) BE0000074 Nuclear receptor subfamily 0 group B member 1 (1) --------------------------------------------------- Drug1 : DB00253 Medrysone Drug2 : DB01260 Desonide Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00253 Medrysone Drug2 : DB01380 Cortisone acetate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00253 Medrysone Drug2 : DB01384 Paramethasone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00253 Medrysone Drug2 : DB01410 Ciclesonide Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00253 Medrysone Drug2 : DB06781 Difluprednate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00253 Medrysone Drug2 : DB08906 Fluticasone furoate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00255 Diethylstilbestrol Drug2 : DB00481 Raloxifene Pharmacological target (+,+) : BE0000123 Estrogen receptor Pharmacological target (+,+) : BE0000792 Estrogen receptor beta Non-common off-target(s) (drug1) : BE0002088 Estrogen-related receptor gamma (1) --------------------------------------------------- Drug1 : DB00255 Diethylstilbestrol Drug2 : DB00783 Estradiol Pharmacological target (+,+) : BE0000123 Estrogen receptor Pharmacological target (+,+) : BE0000792 Estrogen receptor beta Non-common off-target(s) (drug1) : BE0002088 Estrogen-related receptor gamma (1) --------------------------------------------------- Drug1 : DB00261 Anagrelide Drug2 : DB01166 Cilostazol Pharmacological target (-,-) : BE0000436 cGMP-inhibited 3',5'-cyclic phosphodiesterase A --------------------------------------------------- Drug1 : DB00261 Anagrelide Drug2 : DB01427 Amrinone Pharmacological target (-,-) : BE0000436 cGMP-inhibited 3',5'-cyclic phosphodiesterase A Non-common off-target(s) (drug2) : BE0000704 Tumor necrosis factor (-1) BE0000487 cAMP-specific 3',5'-cyclic phosphodiesterase 4B (-1) --------------------------------------------------- Drug1 : DB00261 Anagrelide Drug2 : DB04880 Enoximone Pharmacological target (-,-) : BE0000436 cGMP-inhibited 3',5'-cyclic phosphodiesterase A --------------------------------------------------- Drug1 : DB00264 Metoprolol Drug2 : DB00335 Atenolol Pharmacological target (-,-) : BE0000172 Beta-1 adrenergic receptor Non-common off-target(s) (drug1) : BE0000694 Beta-2 adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00264 Metoprolol Drug2 : DB01297 Practolol Pharmacological target (-,-) : BE0000172 Beta-1 adrenergic receptor Non-common off-target(s) (drug1) : BE0000694 Beta-2 adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00266 Dicoumarol Drug2 : DB00498 Phenindione Pharmacological target (-,-) : BE0000713 Vitamin K epoxide reductase complex subunit 1 Non-common off-target(s) (drug1) : BE0001184 NAD(P)H dehydrogenase [quinone] 1 (-1) BE0001185 Quinone oxidoreductase (-1) --------------------------------------------------- Drug1 : DB00266 Dicoumarol Drug2 : DB00682 Warfarin Pharmacological target (-,-) : BE0000713 Vitamin K epoxide reductase complex subunit 1 Non-common off-target(s) (drug1) : BE0001184 NAD(P)H dehydrogenase [quinone] 1 (-1) BE0001185 Quinone oxidoreductase (-1) --------------------------------------------------- Drug1 : DB00266 Dicoumarol Drug2 : DB00946 Phenprocoumon Pharmacological target (-,-) : BE0000713 Vitamin K epoxide reductase complex subunit 1 Non-common off-target(s) (drug1) : BE0001184 NAD(P)H dehydrogenase [quinone] 1 (-1) BE0001185 Quinone oxidoreductase (-1) --------------------------------------------------- Drug1 : DB00266 Dicoumarol Drug2 : DB01418 Acenocoumarol Pharmacological target (-,-) : BE0000713 Vitamin K epoxide reductase complex subunit 1 Non-common off-target(s) (drug1) : BE0001184 NAD(P)H dehydrogenase [quinone] 1 (-1) BE0001185 Quinone oxidoreductase (-1) --------------------------------------------------- Drug1 : DB00268 Ropinirole Drug2 : DB00915 Amantadine Pharmacological target (+,+) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (1) BE0000659 5-hydroxytryptamine receptor 1D (1) BE0000797 5-hydroxytryptamine receptor 1B (1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000393 5-hydroxytryptamine receptor 2B (1) BE0000451 5-hydroxytryptamine receptor 2A (1) BE0000020 D(1A) dopamine receptor (1) BE0000145 D(1B) dopamine receptor (1) BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) --------------------------------------------------- Drug1 : DB00269 Chlorotrianisene Drug2 : DB00286 Conjugated Estrogens Pharmacological target (+,+) : BE0000123 Estrogen receptor --------------------------------------------------- Drug1 : DB00269 Chlorotrianisene Drug2 : DB00294 Etonogestrel Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug2) : BE0000557 Progesterone receptor (1) --------------------------------------------------- Drug1 : DB00269 Chlorotrianisene Drug2 : DB00304 Desogestrel Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug2) : BE0000557 Progesterone receptor (1) --------------------------------------------------- Drug1 : DB00269 Chlorotrianisene Drug2 : DB00481 Raloxifene Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug2) : BE0000792 Estrogen receptor beta (1) --------------------------------------------------- Drug1 : DB00269 Chlorotrianisene Drug2 : DB00603 Medroxyprogesterone Acetate Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug2) : BE0000557 Progesterone receptor (1) --------------------------------------------------- Drug1 : DB00269 Chlorotrianisene Drug2 : DB00655 Estrone Pharmacological target (+,+) : BE0000123 Estrogen receptor --------------------------------------------------- Drug1 : DB00269 Chlorotrianisene Drug2 : DB00783 Estradiol Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug2) : BE0000792 Estrogen receptor beta (1) --------------------------------------------------- Drug1 : DB00269 Chlorotrianisene Drug2 : DB00823 Ethynodiol Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug2) : BE0000557 Progesterone receptor (1) --------------------------------------------------- Drug1 : DB00269 Chlorotrianisene Drug2 : DB00890 Dienestrol Pharmacological target (+,+) : BE0000123 Estrogen receptor --------------------------------------------------- Drug1 : DB00269 Chlorotrianisene Drug2 : DB00957 Norgestimate Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug2) : BE0000557 Progesterone receptor (1) --------------------------------------------------- Drug1 : DB00269 Chlorotrianisene Drug2 : DB00977 Ethinyl Estradiol Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug2) : BE0000956 Nuclear receptor subfamily 1 group I member 2 (1) --------------------------------------------------- Drug1 : DB00269 Chlorotrianisene Drug2 : DB01357 Mestranol Pharmacological target (+,+) : BE0000123 Estrogen receptor --------------------------------------------------- Drug1 : DB00269 Chlorotrianisene Drug2 : DB04573 Estriol Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug2) : BE0000792 Estrogen receptor beta (1) --------------------------------------------------- Drug1 : DB00269 Chlorotrianisene Drug2 : DB04574 Estropipate Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug2) : BE0000792 Estrogen receptor beta (1) --------------------------------------------------- Drug1 : DB00269 Chlorotrianisene Drug2 : DB04575 Quinestrol Pharmacological target (+,+) : BE0000123 Estrogen receptor --------------------------------------------------- Drug1 : DB00270 Isradipine Drug2 : DB00381 Amlodipine Pharmacological target (-,-) : BE0000430 Voltage-dependent L-type calcium channel subunit alpha-1C Pharmacological target (-,-) : BE0000691 Voltage-dependent calcium channel subunit alpha-2/delta-1 Pharmacological target (-,-) : BE0002354 Voltage-dependent L-type calcium channel subunit beta-2 Pharmacological target (-,-) : BE0002359 Voltage-dependent L-type calcium channel subunit alpha-1D Pharmacological target (-,-) : BE0002355 Voltage-dependent L-type calcium channel subunit alpha-1S Non-common off-target(s) (drug1) : BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0002396 Voltage-dependent calcium channel subunit alpha-2/delta-2 (-1) Non-common off-target(s) (drug2) : BE0000267 Carbonic anhydrase 1 (-1) BE0002226 Voltage-dependent N-type calcium channel subunit alpha-1B (-1) BE0003563 Voltage-dependent calcium channel subunit alpha-2/delta-3 (-1) BE0003564 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d (-1) --------------------------------------------------- Drug1 : DB00270 Isradipine Drug2 : DB00393 Nimodipine Pharmacological target (-,-) : BE0000430 Voltage-dependent L-type calcium channel subunit alpha-1C Pharmacological target (-,-) : BE0002354 Voltage-dependent L-type calcium channel subunit beta-2 Pharmacological target (-,-) : BE0002359 Voltage-dependent L-type calcium channel subunit alpha-1D Pharmacological target (-,-) : BE0002355 Voltage-dependent L-type calcium channel subunit alpha-1S Non-common off-target(s) (drug1) : BE0000691 Voltage-dependent calcium channel subunit alpha-2/delta-1 (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0002396 Voltage-dependent calcium channel subunit alpha-2/delta-2 (-1) Non-common off-target(s) (drug2) : BE0000303 Voltage-dependent L-type calcium channel subunit beta-1 (-1) BE0003721 Aryl hydrocarbon receptor (1) BE0002357 Voltage-dependent L-type calcium channel subunit alpha-1F (-1) BE0002358 Voltage-dependent L-type calcium channel subunit beta-3 (-1) BE0002356 Voltage-dependent L-type calcium channel subunit beta-4 (-1) BE0000668 Mineralocorticoid receptor (-1) --------------------------------------------------- Drug1 : DB00270 Isradipine Drug2 : DB00401 Nisoldipine Pharmacological target (-,-) : BE0000430 Voltage-dependent L-type calcium channel subunit alpha-1C Pharmacological target (-,-) : BE0000691 Voltage-dependent calcium channel subunit alpha-2/delta-1 Pharmacological target (-,-) : BE0002354 Voltage-dependent L-type calcium channel subunit beta-2 Pharmacological target (-,-) : BE0002359 Voltage-dependent L-type calcium channel subunit alpha-1D Pharmacological target (-,-) : BE0002355 Voltage-dependent L-type calcium channel subunit alpha-1S Non-common off-target(s) (drug1) : BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0002396 Voltage-dependent calcium channel subunit alpha-2/delta-2 (-1) --------------------------------------------------- Drug1 : DB00270 Isradipine Drug2 : DB00568 Cinnarizine Pharmacological target (-,-) : BE0000430 Voltage-dependent L-type calcium channel subunit alpha-1C Pharmacological target (-,-) : BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H Pharmacological target (-,-) : BE0002359 Voltage-dependent L-type calcium channel subunit alpha-1D Pharmacological target (-,-) : BE0002355 Voltage-dependent L-type calcium channel subunit alpha-1S Non-common off-target(s) (drug1) : BE0000691 Voltage-dependent calcium channel subunit alpha-2/delta-1 (-1) BE0002354 Voltage-dependent L-type calcium channel subunit beta-2 (-1) BE0002396 Voltage-dependent calcium channel subunit alpha-2/delta-2 (-1) Non-common off-target(s) (drug2) : BE0000442 Histamine H1 receptor (-1) BE0000483 Voltage-dependent T-type calcium channel subunit alpha-1G (-1) BE0002357 Voltage-dependent L-type calcium channel subunit alpha-1F (-1) BE0000012 Voltage-dependent T-type calcium channel subunit alpha-1I (-1) --------------------------------------------------- Drug1 : DB00270 Isradipine Drug2 : DB00622 Nicardipine Pharmacological target (-,-) : BE0000430 Voltage-dependent L-type calcium channel subunit alpha-1C Pharmacological target (-,-) : BE0000691 Voltage-dependent calcium channel subunit alpha-2/delta-1 Pharmacological target (-,-) : BE0002354 Voltage-dependent L-type calcium channel subunit beta-2 Pharmacological target (-,-) : BE0002359 Voltage-dependent L-type calcium channel subunit alpha-1D Non-common off-target(s) (drug1) : BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0002396 Voltage-dependent calcium channel subunit alpha-2/delta-2 (-1) BE0002355 Voltage-dependent L-type calcium channel subunit alpha-1S (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0003565 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (-1) BE0003323 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (-1) --------------------------------------------------- Drug1 : DB00270 Isradipine Drug2 : DB00661 Verapamil Pharmacological target (-,-) : BE0000430 Voltage-dependent L-type calcium channel subunit alpha-1C Pharmacological target (-,-) : BE0002354 Voltage-dependent L-type calcium channel subunit beta-2 Pharmacological target (-,-) : BE0002359 Voltage-dependent L-type calcium channel subunit alpha-1D Pharmacological target (-,-) : BE0002355 Voltage-dependent L-type calcium channel subunit alpha-1S Non-common off-target(s) (drug1) : BE0000691 Voltage-dependent calcium channel subunit alpha-2/delta-1 (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0002396 Voltage-dependent calcium channel subunit alpha-2/delta-2 (-1) Non-common off-target(s) (drug2) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000708 ATP-sensitive inward rectifier potassium channel 11 (-1) BE0000356 Voltage-dependent P/Q-type calcium channel subunit alpha-1A (-1) BE0000303 Voltage-dependent L-type calcium channel subunit beta-1 (-1) BE0000483 Voltage-dependent T-type calcium channel subunit alpha-1G (-1) BE0002226 Voltage-dependent N-type calcium channel subunit alpha-1B (-1) BE0002357 Voltage-dependent L-type calcium channel subunit alpha-1F (-1) BE0002358 Voltage-dependent L-type calcium channel subunit beta-3 (-1) BE0002356 Voltage-dependent L-type calcium channel subunit beta-4 (-1) BE0000012 Voltage-dependent T-type calcium channel subunit alpha-1I (-1) --------------------------------------------------- Drug1 : DB00275 Olmesartan Drug2 : DB00678 Losartan Pharmacological target (-,-) : BE0000062 Type-1 angiotensin II receptor --------------------------------------------------- Drug1 : DB00275 Olmesartan Drug2 : DB00796 Candesartan Pharmacological target (-,-) : BE0000062 Type-1 angiotensin II receptor --------------------------------------------------- Drug1 : DB00275 Olmesartan Drug2 : DB00876 Eprosartan Pharmacological target (-,-) : BE0000062 Type-1 angiotensin II receptor --------------------------------------------------- Drug1 : DB00275 Olmesartan Drug2 : DB00966 Telmisartan Pharmacological target (-,-) : BE0000062 Type-1 angiotensin II receptor Non-common off-target(s) (drug2) : BE0000215 Peroxisome proliferator-activated receptor gamma (1) --------------------------------------------------- Drug1 : DB00275 Olmesartan Drug2 : DB01029 Irbesartan Pharmacological target (-,-) : BE0000062 Type-1 angiotensin II receptor --------------------------------------------------- Drug1 : DB00275 Olmesartan Drug2 : DB01342 Forasartan Pharmacological target (-,-) : BE0000062 Type-1 angiotensin II receptor --------------------------------------------------- Drug1 : DB00275 Olmesartan Drug2 : DB01347 Saprisartan Pharmacological target (-,-) : BE0000062 Type-1 angiotensin II receptor --------------------------------------------------- Drug1 : DB00275 Olmesartan Drug2 : DB01349 Tasosartan Pharmacological target (-,-) : BE0000062 Type-1 angiotensin II receptor Non-common off-target(s) (drug2) : BE0003426 Type-2 angiotensin II receptor (-1) --------------------------------------------------- Drug1 : DB00275 Olmesartan Drug2 : DB08822 Azilsartan medoxomil Pharmacological target (-,-) : BE0000062 Type-1 angiotensin II receptor --------------------------------------------------- Drug1 : DB00276 Amsacrine Drug2 : DB00380 Dexrazoxane Pharmacological target (-,-) : BE0000742 DNA topoisomerase 2-alpha Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) --------------------------------------------------- Drug1 : DB00276 Amsacrine Drug2 : DB00385 Valrubicin Pharmacological target (-,-) : BE0000742 DNA topoisomerase 2-alpha Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) --------------------------------------------------- Drug1 : DB00276 Amsacrine Drug2 : DB00444 Teniposide Pharmacological target (-,-) : BE0000742 DNA topoisomerase 2-alpha Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) --------------------------------------------------- Drug1 : DB00276 Amsacrine Drug2 : DB00694 Daunorubicin Pharmacological target (-,-) : BE0000742 DNA topoisomerase 2-alpha Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) Non-common off-target(s) (drug2) : BE0002425 DNA topoisomerase 2-beta (-1) --------------------------------------------------- Drug1 : DB00276 Amsacrine Drug2 : DB00773 Etoposide Pharmacological target (-,-) : BE0000742 DNA topoisomerase 2-alpha Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) Non-common off-target(s) (drug2) : BE0002425 DNA topoisomerase 2-beta (-1) --------------------------------------------------- Drug1 : DB00276 Amsacrine Drug2 : DB00997 Doxorubicin Pharmacological target (-,-) : BE0000742 DNA topoisomerase 2-alpha Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) --------------------------------------------------- Drug1 : DB00276 Amsacrine Drug2 : DB01137 Levofloxacin Pharmacological target (-,-) : BE0000742 DNA topoisomerase 2-alpha Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) --------------------------------------------------- Drug1 : DB00276 Amsacrine Drug2 : DB01177 Idarubicin Pharmacological target (-,-) : BE0000742 DNA topoisomerase 2-alpha Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) --------------------------------------------------- Drug1 : DB00276 Amsacrine Drug2 : DB01204 Mitoxantrone Pharmacological target (-,-) : BE0000742 DNA topoisomerase 2-alpha Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) --------------------------------------------------- Drug1 : DB00276 Amsacrine Drug2 : DB01208 Sparfloxacin Pharmacological target (-,-) : BE0000742 DNA topoisomerase 2-alpha Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) --------------------------------------------------- Drug1 : DB00276 Amsacrine Drug2 : DB04576 Fleroxacin Pharmacological target (-,-) : BE0000742 DNA topoisomerase 2-alpha Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) --------------------------------------------------- Drug1 : DB00276 Amsacrine Drug2 : DB09047 Finafloxacin Pharmacological target (-,-) : BE0000742 DNA topoisomerase 2-alpha Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) --------------------------------------------------- Drug1 : DB00277 Theophylline Drug2 : DB00651 Dyphylline Pharmacological target (-,-) : BE0000487 cAMP-specific 3',5'-cyclic phosphodiesterase 4B Pharmacological target (-,-) : BE0000013 Adenosine receptor A1 Pharmacological target (-,-) : BE0000924 Adenosine receptor A2a Pharmacological target (-,-) : BE0001133 cAMP-specific 3',5'-cyclic phosphodiesterase 4A Non-common off-target(s) (drug1) : BE0000182 cGMP-specific 3',5'-cyclic phosphodiesterase (-1) BE0002366 Histone deacetylase 2 (1) BE0000436 cGMP-inhibited 3',5'-cyclic phosphodiesterase A (-1) BE0000241 Adenosine receptor A2b (-1) Non-common off-target(s) (drug2) : BE0001287 cAMP-specific 3',5'-cyclic phosphodiesterase 4D (-1) BE0002353 cAMP-specific 3',5'-cyclic phosphodiesterase 4C (-1) BE0000706 High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (-1) BE0000627 cAMP-specific 3',5'-cyclic phosphodiesterase 7B (-1) --------------------------------------------------- Drug1 : DB00277 Theophylline Drug2 : DB00806 Pentoxifylline Pharmacological target (-,-) : BE0000487 cAMP-specific 3',5'-cyclic phosphodiesterase 4B Pharmacological target (-,-) : BE0000013 Adenosine receptor A1 Pharmacological target (-,-) : BE0000924 Adenosine receptor A2a Pharmacological target (-,-) : BE0000182 cGMP-specific 3',5'-cyclic phosphodiesterase Pharmacological target (-,-) : BE0001133 cAMP-specific 3',5'-cyclic phosphodiesterase 4A Non-common off-target(s) (drug1) : BE0002366 Histone deacetylase 2 (1) BE0000436 cGMP-inhibited 3',5'-cyclic phosphodiesterase A (-1) BE0000241 Adenosine receptor A2b (-1) Non-common off-target(s) (drug2) : BE0001096 5'-nucleotidase (-1) --------------------------------------------------- Drug1 : DB00277 Theophylline Drug2 : DB01303 Oxtriphylline Pharmacological target (+,+) : BE0002366 Histone deacetylase 2 Pharmacological target (-,-) : BE0000013 Adenosine receptor A1 Pharmacological target (-,-) : BE0000924 Adenosine receptor A2a Pharmacological target (-,-) : BE0000436 cGMP-inhibited 3',5'-cyclic phosphodiesterase A Pharmacological target (-,-) : BE0001133 cAMP-specific 3',5'-cyclic phosphodiesterase 4A Non-common off-target(s) (drug1) : BE0000487 cAMP-specific 3',5'-cyclic phosphodiesterase 4B (-1) BE0000182 cGMP-specific 3',5'-cyclic phosphodiesterase (-1) BE0000241 Adenosine receptor A2b (-1) --------------------------------------------------- Drug1 : DB00278 Argatroban Drug2 : DB04898 Ximelagatran Pharmacological target (-,-) : BE0000048 Prothrombin --------------------------------------------------- Drug1 : DB00278 Argatroban Drug2 : DB06695 Dabigatran etexilate Pharmacological target (-,-) : BE0000048 Prothrombin --------------------------------------------------- Drug1 : DB00279 Liothyronine Drug2 : DB00451 Levothyroxine Pharmacological target (+,+) : BE0000687 Thyroid hormone receptor alpha Pharmacological target (+,+) : BE0000315 Thyroid hormone receptor beta --------------------------------------------------- Drug1 : DB00279 Liothyronine Drug2 : DB00509 Dextrothyroxine Pharmacological target (+,+) : BE0000687 Thyroid hormone receptor alpha Pharmacological target (+,+) : BE0000315 Thyroid hormone receptor beta --------------------------------------------------- Drug1 : DB00279 Liothyronine Drug2 : DB01583 Liotrix Pharmacological target (+,+) : BE0000687 Thyroid hormone receptor alpha Pharmacological target (+,+) : BE0000315 Thyroid hormone receptor beta --------------------------------------------------- Drug1 : DB00280 Disopyramide Drug2 : DB00379 Mexiletine Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0003603 Potassium voltage-gated channel subfamily D member 2 (-1) BE0003604 Potassium voltage-gated channel subfamily D member 3 (-1) Non-common off-target(s) (drug2) : BE0003721 Aryl hydrocarbon receptor (1) --------------------------------------------------- Drug1 : DB00280 Disopyramide Drug2 : DB00473 Hexylcaine Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0003603 Potassium voltage-gated channel subfamily D member 2 (-1) BE0003604 Potassium voltage-gated channel subfamily D member 3 (-1) Non-common off-target(s) (drug2) : BE0000177 Sodium channel protein type 10 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00280 Disopyramide Drug2 : DB00527 Cinchocaine Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0003603 Potassium voltage-gated channel subfamily D member 2 (-1) BE0003604 Potassium voltage-gated channel subfamily D member 3 (-1) Non-common off-target(s) (drug2) : BE0000177 Sodium channel protein type 10 subunit alpha (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00280 Disopyramide Drug2 : DB00532 Mephenytoin Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0003603 Potassium voltage-gated channel subfamily D member 2 (-1) BE0003604 Potassium voltage-gated channel subfamily D member 3 (-1) --------------------------------------------------- Drug1 : DB00280 Disopyramide Drug2 : DB00564 Carbamazepine Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0003603 Potassium voltage-gated channel subfamily D member 2 (-1) BE0003604 Potassium voltage-gated channel subfamily D member 3 (-1) --------------------------------------------------- Drug1 : DB00280 Disopyramide Drug2 : DB00680 Moricizine Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0003603 Potassium voltage-gated channel subfamily D member 2 (-1) BE0003604 Potassium voltage-gated channel subfamily D member 3 (-1) --------------------------------------------------- Drug1 : DB00280 Disopyramide Drug2 : DB00740 Riluzole Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0003603 Potassium voltage-gated channel subfamily D member 2 (-1) BE0003604 Potassium voltage-gated channel subfamily D member 3 (-1) Non-common off-target(s) (drug2) : BE0000030 Cystine/glutamate transporter (1) --------------------------------------------------- Drug1 : DB00280 Disopyramide Drug2 : DB00750 Prilocaine Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0003603 Potassium voltage-gated channel subfamily D member 2 (-1) BE0003604 Potassium voltage-gated channel subfamily D member 3 (-1) --------------------------------------------------- Drug1 : DB00280 Disopyramide Drug2 : DB00754 Ethotoin Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0003603 Potassium voltage-gated channel subfamily D member 2 (-1) BE0003604 Potassium voltage-gated channel subfamily D member 3 (-1) --------------------------------------------------- Drug1 : DB00280 Disopyramide Drug2 : DB00776 Oxcarbazepine Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0003603 Potassium voltage-gated channel subfamily D member 2 (-1) BE0003604 Potassium voltage-gated channel subfamily D member 3 (-1) --------------------------------------------------- Drug1 : DB00280 Disopyramide Drug2 : DB00908 Quinidine Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0003603 Potassium voltage-gated channel subfamily D member 2 (-1) BE0003604 Potassium voltage-gated channel subfamily D member 3 (-1) Non-common off-target(s) (drug2) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000154 Potassium channel subfamily K member 1 (-1) BE0000680 Potassium channel subfamily K member 6 (-1) --------------------------------------------------- Drug1 : DB00280 Disopyramide Drug2 : DB01056 Tocainide Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0003603 Potassium voltage-gated channel subfamily D member 2 (-1) BE0003604 Potassium voltage-gated channel subfamily D member 3 (-1) --------------------------------------------------- Drug1 : DB00280 Disopyramide Drug2 : DB01182 Propafenone Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0003603 Potassium voltage-gated channel subfamily D member 2 (-1) BE0003604 Potassium voltage-gated channel subfamily D member 3 (-1) Non-common off-target(s) (drug2) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) --------------------------------------------------- Drug1 : DB00280 Disopyramide Drug2 : DB01195 Flecainide Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0003603 Potassium voltage-gated channel subfamily D member 2 (-1) BE0003604 Potassium voltage-gated channel subfamily D member 3 (-1) Non-common off-target(s) (drug2) : BE0002083 Sodium channel protein type 4 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00280 Disopyramide Drug2 : DB01228 Encainide Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0003603 Potassium voltage-gated channel subfamily D member 2 (-1) BE0003604 Potassium voltage-gated channel subfamily D member 3 (-1) --------------------------------------------------- Drug1 : DB00280 Disopyramide Drug2 : DB01320 Fosphenytoin Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0003603 Potassium voltage-gated channel subfamily D member 2 (-1) BE0003604 Potassium voltage-gated channel subfamily D member 3 (-1) --------------------------------------------------- Drug1 : DB00280 Disopyramide Drug2 : DB01426 Ajmaline Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0003603 Potassium voltage-gated channel subfamily D member 2 (-1) BE0003604 Potassium voltage-gated channel subfamily D member 3 (-1) --------------------------------------------------- Drug1 : DB00280 Disopyramide Drug2 : DB01429 Aprindine Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0003603 Potassium voltage-gated channel subfamily D member 2 (-1) BE0003604 Potassium voltage-gated channel subfamily D member 3 (-1) Non-common off-target(s) (drug2) : BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00281 Lidocaine Drug2 : DB00527 Cinchocaine Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Pharmacological target (-,-) : BE0000177 Sodium channel protein type 10 subunit alpha Non-common off-target(s) (drug1) : BE0000767 Epidermal growth factor receptor (-1) BE0001143 Sodium channel protein type 9 subunit alpha (-1) Non-common off-target(s) (drug2) : BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00282 Pamidronate Drug2 : DB00399 Zoledronate Pharmacological target (-,-) : BE0000776 Farnesyl pyrophosphate synthase Pharmacological target (-,-) : BE0004801 Hydroxylapatite Non-common off-target(s) (drug2) : BE0003570 Geranylgeranyl pyrophosphate synthase (-1) --------------------------------------------------- Drug1 : DB00282 Pamidronate Drug2 : DB00630 Alendronate Pharmacological target (-,-) : BE0000776 Farnesyl pyrophosphate synthase Pharmacological target (-,-) : BE0004801 Hydroxylapatite Non-common off-target(s) (drug2) : BE0000980 Tyrosine-protein phosphatase non-receptor type 4 (-1) BE0003567 Receptor-type tyrosine-protein phosphatase S (-1) BE0003568 Receptor-type tyrosine-protein phosphatase epsilon (-1) BE0003569 V-type proton ATPase catalytic subunit A (-1) --------------------------------------------------- Drug1 : DB00282 Pamidronate Drug2 : DB00710 Ibandronate Pharmacological target (-,-) : BE0000776 Farnesyl pyrophosphate synthase Pharmacological target (-,-) : BE0004801 Hydroxylapatite --------------------------------------------------- Drug1 : DB00282 Pamidronate Drug2 : DB00884 Risedronate Pharmacological target (-,-) : BE0000776 Farnesyl pyrophosphate synthase Pharmacological target (-,-) : BE0004801 Hydroxylapatite --------------------------------------------------- Drug1 : DB00282 Pamidronate Drug2 : DB01077 Etidronic acid Pharmacological target (-,-) : BE0004801 Hydroxylapatite Non-common off-target(s) (drug1) : BE0000776 Farnesyl pyrophosphate synthase (-1) Non-common off-target(s) (drug2) : BE0003567 Receptor-type tyrosine-protein phosphatase S (-1) BE0003569 V-type proton ATPase catalytic subunit A (-1) --------------------------------------------------- Drug1 : DB00282 Pamidronate Drug2 : DB01133 Tiludronate Pharmacological target (-,-) : BE0004801 Hydroxylapatite Non-common off-target(s) (drug1) : BE0000776 Farnesyl pyrophosphate synthase (-1) Non-common off-target(s) (drug2) : BE0003569 V-type proton ATPase catalytic subunit A (-1) BE0000623 Tyrosine-protein phosphatase non-receptor type 1 (-1) --------------------------------------------------- Drug1 : DB00283 Clemastine Drug2 : DB00341 Cetirizine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00283 Clemastine Drug2 : DB00342 Terfenadine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) --------------------------------------------------- Drug1 : DB00283 Clemastine Drug2 : DB00354 Buclizine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) --------------------------------------------------- Drug1 : DB00283 Clemastine Drug2 : DB00366 Doxylamine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) --------------------------------------------------- Drug1 : DB00283 Clemastine Drug2 : DB00405 Dexbrompheniramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00283 Clemastine Drug2 : DB00427 Triprolidine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00283 Clemastine Drug2 : DB00455 Loratadine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00283 Clemastine Drug2 : DB00557 Hydroxyzine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00283 Clemastine Drug2 : DB00637 Astemizole Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) --------------------------------------------------- Drug1 : DB00283 Clemastine Drug2 : DB00719 Azatadine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00283 Clemastine Drug2 : DB00737 Meclizine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00283 Clemastine Drug2 : DB00748 Carbinoxamine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00283 Clemastine Drug2 : DB00751 Epinastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000112 Histamine H2 receptor (-1) --------------------------------------------------- Drug1 : DB00283 Clemastine Drug2 : DB00768 Olopatadine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0001090 Protein S100-A1 (-1) BE0001206 Protein S100-A12 (-1) BE0003602 Protein S100-A2 (-1) --------------------------------------------------- Drug1 : DB00283 Clemastine Drug2 : DB00777 Propiomazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00283 Clemastine Drug2 : DB00792 Tripelennamine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00283 Clemastine Drug2 : DB00835 Brompheniramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00283 Clemastine Drug2 : DB00902 Methdilazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00283 Clemastine Drug2 : DB00950 Fexofenadine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00283 Clemastine Drug2 : DB00967 Desloratadine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00283 Clemastine Drug2 : DB00972 Azelastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00283 Clemastine Drug2 : DB00985 Dimenhydrinate Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00283 Clemastine Drug2 : DB01069 Promethazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00283 Clemastine Drug2 : DB01071 Mequitazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00283 Clemastine Drug2 : DB01075 Diphenhydramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00283 Clemastine Drug2 : DB01084 Emedastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00283 Clemastine Drug2 : DB01106 Levocabastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000464 Neurotensin receptor type 2 (-1) --------------------------------------------------- Drug1 : DB00283 Clemastine Drug2 : DB01114 Chlorphenamine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB00283 Clemastine Drug2 : DB01146 Diphenylpyraline Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB00283 Clemastine Drug2 : DB01176 Cyclizine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000951 Estrogen sulfotransferase (-1) --------------------------------------------------- Drug1 : DB00283 Clemastine Drug2 : DB01237 Bromodiphenhydramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00283 Clemastine Drug2 : DB01246 Alimemazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00283 Clemastine Drug2 : DB01615 Aceprometazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00283 Clemastine Drug2 : DB01619 Phenindamine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00283 Clemastine Drug2 : DB01620 Pheniramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00283 Clemastine Drug2 : DB04837 Clofedanol Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00283 Clemastine Drug2 : DB04890 Bepotastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00283 Clemastine Drug2 : DB06691 Mepyramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00283 Clemastine Drug2 : DB08799 Antazoline Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00283 Clemastine Drug2 : DB08800 Chloropyramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00283 Clemastine Drug2 : DB08801 Dimetindene Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00283 Clemastine Drug2 : DB08802 Isothipendyl Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00283 Clemastine Drug2 : DB08936 Chlorcyclizine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00284 Acarbose Drug2 : DB00491 Miglitol Pharmacological target (-,-) : BE0000837 Maltase-glucoamylase, intestinal Pharmacological target (-,-) : BE0000876 Lysosomal alpha-glucosidase Non-common off-target(s) (drug1) : BE0002639 Pancreatic alpha-amylase (-1) BE0001176 Sucrase-isomaltase, intestinal (-1) Non-common off-target(s) (drug2) : BE0004698 Neutral alpha-glucosidase AB (-1) BE0004699 Neutral alpha-glucosidase C (-1) --------------------------------------------------- Drug1 : DB00285 Venlafaxine Drug2 : DB00321 Amitriptyline Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000781 Potassium voltage-gated channel subfamily A member 1 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000112 Histamine H2 receptor (-1) BE0003603 Potassium voltage-gated channel subfamily D member 2 (-1) BE0003604 Potassium voltage-gated channel subfamily D member 3 (-1) BE0001039 High affinity nerve growth factor receptor (1) BE0003605 BDNF/NT-3 growth factors receptor (1) BE0000897 Potassium voltage-gated channel subfamily KQT member 2 (-1) BE0000156 Sigma non-opioid intracellular receptor 1 (1) --------------------------------------------------- Drug1 : DB00285 Venlafaxine Drug2 : DB00344 Protriptyline Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB00285 Venlafaxine Drug2 : DB00458 Imipramine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0003603 Potassium voltage-gated channel subfamily D member 2 (-1) BE0003604 Potassium voltage-gated channel subfamily D member 3 (-1) --------------------------------------------------- Drug1 : DB00285 Venlafaxine Drug2 : DB00472 Fluoxetine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB00285 Venlafaxine Drug2 : DB00540 Nortriptyline Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) Non-common off-target(s) (drug2) : BE0004872 Beta adrenergic receptor (-1) BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0004864 Alpha-2 adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00285 Venlafaxine Drug2 : DB00934 Maprotiline Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000442 Histamine H1 receptor (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0004864 Alpha-2 adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0004863 Alpha-1 adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00285 Venlafaxine Drug2 : DB01151 Desipramine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000694 Beta-2 adrenergic receptor (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000442 Histamine H1 receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0004863 Alpha-1 adrenergic receptor (-1) BE0000973 Sphingomyelin phosphodiesterase (-1) --------------------------------------------------- Drug1 : DB00285 Venlafaxine Drug2 : DB01191 Dexfenfluramine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) Non-common off-target(s) (drug2) : BE0000533 5-hydroxytryptamine receptor 2C (1) --------------------------------------------------- Drug1 : DB00285 Venlafaxine Drug2 : DB01579 Phendimetrazine Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00285 Venlafaxine Drug2 : DB04896 Milnacipran Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) Non-common off-target(s) (drug2) : BE0004956 NMDA receptor (-1) --------------------------------------------------- Drug1 : DB00285 Venlafaxine Drug2 : DB06700 Desvenlafaxine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB00285 Venlafaxine Drug2 : DB08918 Levomilnacipran Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB00286 Conjugated Estrogens Drug2 : DB00294 Etonogestrel Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug2) : BE0000557 Progesterone receptor (1) --------------------------------------------------- Drug1 : DB00286 Conjugated Estrogens Drug2 : DB00304 Desogestrel Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug2) : BE0000557 Progesterone receptor (1) --------------------------------------------------- Drug1 : DB00286 Conjugated Estrogens Drug2 : DB00481 Raloxifene Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug2) : BE0000792 Estrogen receptor beta (1) --------------------------------------------------- Drug1 : DB00286 Conjugated Estrogens Drug2 : DB00603 Medroxyprogesterone Acetate Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug2) : BE0000557 Progesterone receptor (1) --------------------------------------------------- Drug1 : DB00286 Conjugated Estrogens Drug2 : DB00655 Estrone Pharmacological target (+,+) : BE0000123 Estrogen receptor --------------------------------------------------- Drug1 : DB00286 Conjugated Estrogens Drug2 : DB00783 Estradiol Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug2) : BE0000792 Estrogen receptor beta (1) --------------------------------------------------- Drug1 : DB00286 Conjugated Estrogens Drug2 : DB00823 Ethynodiol Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug2) : BE0000557 Progesterone receptor (1) --------------------------------------------------- Drug1 : DB00286 Conjugated Estrogens Drug2 : DB00890 Dienestrol Pharmacological target (+,+) : BE0000123 Estrogen receptor --------------------------------------------------- Drug1 : DB00286 Conjugated Estrogens Drug2 : DB00957 Norgestimate Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug2) : BE0000557 Progesterone receptor (1) --------------------------------------------------- Drug1 : DB00286 Conjugated Estrogens Drug2 : DB00977 Ethinyl Estradiol Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug2) : BE0000956 Nuclear receptor subfamily 1 group I member 2 (1) --------------------------------------------------- Drug1 : DB00286 Conjugated Estrogens Drug2 : DB01357 Mestranol Pharmacological target (+,+) : BE0000123 Estrogen receptor --------------------------------------------------- Drug1 : DB00286 Conjugated Estrogens Drug2 : DB04573 Estriol Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug2) : BE0000792 Estrogen receptor beta (1) --------------------------------------------------- Drug1 : DB00286 Conjugated Estrogens Drug2 : DB04574 Estropipate Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug2) : BE0000792 Estrogen receptor beta (1) --------------------------------------------------- Drug1 : DB00286 Conjugated Estrogens Drug2 : DB04575 Quinestrol Pharmacological target (+,+) : BE0000123 Estrogen receptor --------------------------------------------------- Drug1 : DB00287 Travoprost Drug2 : DB00654 Latanoprost Pharmacological target (+,+) : BE0000610 Prostaglandin F2-alpha receptor --------------------------------------------------- Drug1 : DB00287 Travoprost Drug2 : DB01160 Dinoprost Tromethamine Pharmacological target (+,+) : BE0000610 Prostaglandin F2-alpha receptor Non-common off-target(s) (drug2) : BE0000475 Prostacyclin receptor (-1) --------------------------------------------------- Drug1 : DB00287 Travoprost Drug2 : DB08819 Tafluprost Pharmacological target (+,+) : BE0000610 Prostaglandin F2-alpha receptor --------------------------------------------------- Drug1 : DB00288 Amcinonide Drug2 : DB00324 Fluorometholone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug1) : BE0000422 Annexin A1 (1) --------------------------------------------------- Drug1 : DB00288 Amcinonide Drug2 : DB00394 Beclomethasone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug1) : BE0000422 Annexin A1 (1) --------------------------------------------------- Drug1 : DB00288 Amcinonide Drug2 : DB00443 Betamethasone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug1) : BE0000422 Annexin A1 (1) --------------------------------------------------- Drug1 : DB00288 Amcinonide Drug2 : DB00547 Desoximetasone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug1) : BE0000422 Annexin A1 (1) --------------------------------------------------- Drug1 : DB00288 Amcinonide Drug2 : DB00588 Fluticasone Propionate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug1) : BE0000422 Annexin A1 (1) Non-common off-target(s) (drug2) : BE0000557 Progesterone receptor (1) BE0000668 Mineralocorticoid receptor (-1) BE0000657 Cytosolic phospholipase A2 (-1) --------------------------------------------------- Drug1 : DB00288 Amcinonide Drug2 : DB00591 Fluocinolone Acetonide Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug1) : BE0000422 Annexin A1 (1) --------------------------------------------------- Drug1 : DB00288 Amcinonide Drug2 : DB00596 Halobetasol Propionate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug1) : BE0000422 Annexin A1 (1) --------------------------------------------------- Drug1 : DB00288 Amcinonide Drug2 : DB00620 Triamcinolone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug1) : BE0000422 Annexin A1 (1) --------------------------------------------------- Drug1 : DB00288 Amcinonide Drug2 : DB00635 Prednisone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug1) : BE0000422 Annexin A1 (1) --------------------------------------------------- Drug1 : DB00288 Amcinonide Drug2 : DB00663 Flumethasone Pivalate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug1) : BE0000422 Annexin A1 (1) --------------------------------------------------- Drug1 : DB00288 Amcinonide Drug2 : DB00764 Mometasone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug1) : BE0000422 Annexin A1 (1) --------------------------------------------------- Drug1 : DB00288 Amcinonide Drug2 : DB00769 Hydrocortamate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug1) : BE0000422 Annexin A1 (1) --------------------------------------------------- Drug1 : DB00288 Amcinonide Drug2 : DB00838 Clocortolone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug1) : BE0000422 Annexin A1 (1) --------------------------------------------------- Drug1 : DB00288 Amcinonide Drug2 : DB00846 Flurandrenolide Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug1) : BE0000422 Annexin A1 (1) --------------------------------------------------- Drug1 : DB00288 Amcinonide Drug2 : DB00860 Prednisolone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug1) : BE0000422 Annexin A1 (1) --------------------------------------------------- Drug1 : DB00288 Amcinonide Drug2 : DB00873 Loteprednol Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug1) : BE0000422 Annexin A1 (1) --------------------------------------------------- Drug1 : DB00288 Amcinonide Drug2 : DB00896 Rimexolone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug1) : BE0000422 Annexin A1 (1) --------------------------------------------------- Drug1 : DB00288 Amcinonide Drug2 : DB00959 Methylprednisolone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug1) : BE0000422 Annexin A1 (1) --------------------------------------------------- Drug1 : DB00288 Amcinonide Drug2 : DB01013 Clobetasol propionate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug1) : BE0000422 Annexin A1 (1) --------------------------------------------------- Drug1 : DB00288 Amcinonide Drug2 : DB01047 Fluocinonide Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug1) : BE0000422 Annexin A1 (1) Non-common off-target(s) (drug2) : BE0004659 Smoothened homolog (1) --------------------------------------------------- Drug1 : DB00288 Amcinonide Drug2 : DB01130 Prednicarbate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug1) : BE0000422 Annexin A1 (1) --------------------------------------------------- Drug1 : DB00288 Amcinonide Drug2 : DB01260 Desonide Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug1) : BE0000422 Annexin A1 (1) --------------------------------------------------- Drug1 : DB00288 Amcinonide Drug2 : DB01380 Cortisone acetate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug1) : BE0000422 Annexin A1 (1) --------------------------------------------------- Drug1 : DB00288 Amcinonide Drug2 : DB01384 Paramethasone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug1) : BE0000422 Annexin A1 (1) --------------------------------------------------- Drug1 : DB00288 Amcinonide Drug2 : DB01410 Ciclesonide Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug1) : BE0000422 Annexin A1 (1) --------------------------------------------------- Drug1 : DB00288 Amcinonide Drug2 : DB06781 Difluprednate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug1) : BE0000422 Annexin A1 (1) --------------------------------------------------- Drug1 : DB00288 Amcinonide Drug2 : DB08906 Fluticasone furoate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug1) : BE0000422 Annexin A1 (1) --------------------------------------------------- Drug1 : DB00292 Etomidate Drug2 : DB00402 Eszopiclone Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000572 Alpha-2B adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000736 Translocator protein (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) --------------------------------------------------- Drug1 : DB00292 Etomidate Drug2 : DB01107 Methyprylon Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000572 Alpha-2B adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00292 Etomidate Drug2 : DB01437 Glutethimide Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000572 Alpha-2B adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00293 Raltitrexed Drug2 : DB00432 Trifluridine Pharmacological target (-,-) : BE0000324 Thymidylate synthase Non-common off-target(s) (drug1) : BE0000700 Folylpolyglutamate synthase, mitochondrial (-1) --------------------------------------------------- Drug1 : DB00293 Raltitrexed Drug2 : DB00440 Trimethoprim Pharmacological target (-,-) : BE0000324 Thymidylate synthase Non-common off-target(s) (drug1) : BE0000700 Folylpolyglutamate synthase, mitochondrial (-1) Non-common off-target(s) (drug2) : BE0000330 Dihydrofolate reductase (-1) --------------------------------------------------- Drug1 : DB00293 Raltitrexed Drug2 : DB00650 Leucovorin Pharmacological target (-,-) : BE0000324 Thymidylate synthase Non-common off-target(s) (drug1) : BE0000700 Folylpolyglutamate synthase, mitochondrial (-1) --------------------------------------------------- Drug1 : DB00293 Raltitrexed Drug2 : DB01101 Capecitabine Pharmacological target (-,-) : BE0000324 Thymidylate synthase Non-common off-target(s) (drug1) : BE0000700 Folylpolyglutamate synthase, mitochondrial (-1) --------------------------------------------------- Drug1 : DB00293 Raltitrexed Drug2 : DB06813 Pralatrexate Pharmacological target (-,-) : BE0000324 Thymidylate synthase Non-common off-target(s) (drug1) : BE0000700 Folylpolyglutamate synthase, mitochondrial (-1) Non-common off-target(s) (drug2) : BE0000330 Dihydrofolate reductase (-1) --------------------------------------------------- Drug1 : DB00294 Etonogestrel Drug2 : DB00304 Desogestrel Pharmacological target (+,+) : BE0000123 Estrogen receptor Pharmacological target (+,+) : BE0000557 Progesterone receptor --------------------------------------------------- Drug1 : DB00294 Etonogestrel Drug2 : DB00351 Megestrol acetate Pharmacological target (+,+) : BE0000557 Progesterone receptor Non-common off-target(s) (drug1) : BE0000123 Estrogen receptor (1) Non-common off-target(s) (drug2) : BE0000794 Glucocorticoid receptor (1) --------------------------------------------------- Drug1 : DB00294 Etonogestrel Drug2 : DB00378 Dydrogesterone Pharmacological target (+,+) : BE0000557 Progesterone receptor Non-common off-target(s) (drug1) : BE0000123 Estrogen receptor (1) --------------------------------------------------- Drug1 : DB00294 Etonogestrel Drug2 : DB00396 Progesterone Pharmacological target (+,+) : BE0000123 Estrogen receptor Pharmacological target (+,+) : BE0000557 Progesterone receptor Non-common off-target(s) (drug2) : BE0000344 Steroid 17-alpha-hydroxylase/17,20 lyase (-1) BE0000632 Kappa-type opioid receptor (1) BE0000668 Mineralocorticoid receptor (-1) --------------------------------------------------- Drug1 : DB00294 Etonogestrel Drug2 : DB00481 Raloxifene Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug1) : BE0000557 Progesterone receptor (1) Non-common off-target(s) (drug2) : BE0000792 Estrogen receptor beta (1) --------------------------------------------------- Drug1 : DB00294 Etonogestrel Drug2 : DB00603 Medroxyprogesterone Acetate Pharmacological target (+,+) : BE0000123 Estrogen receptor Pharmacological target (+,+) : BE0000557 Progesterone receptor --------------------------------------------------- Drug1 : DB00294 Etonogestrel Drug2 : DB00655 Estrone Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug1) : BE0000557 Progesterone receptor (1) --------------------------------------------------- Drug1 : DB00294 Etonogestrel Drug2 : DB00783 Estradiol Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug1) : BE0000557 Progesterone receptor (1) Non-common off-target(s) (drug2) : BE0000792 Estrogen receptor beta (1) --------------------------------------------------- Drug1 : DB00294 Etonogestrel Drug2 : DB00823 Ethynodiol Pharmacological target (+,+) : BE0000123 Estrogen receptor Pharmacological target (+,+) : BE0000557 Progesterone receptor --------------------------------------------------- Drug1 : DB00294 Etonogestrel Drug2 : DB00890 Dienestrol Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug1) : BE0000557 Progesterone receptor (1) --------------------------------------------------- Drug1 : DB00294 Etonogestrel Drug2 : DB00957 Norgestimate Pharmacological target (+,+) : BE0000123 Estrogen receptor Pharmacological target (+,+) : BE0000557 Progesterone receptor --------------------------------------------------- Drug1 : DB00294 Etonogestrel Drug2 : DB00977 Ethinyl Estradiol Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug1) : BE0000557 Progesterone receptor (1) Non-common off-target(s) (drug2) : BE0000956 Nuclear receptor subfamily 1 group I member 2 (1) --------------------------------------------------- Drug1 : DB00294 Etonogestrel Drug2 : DB01357 Mestranol Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug1) : BE0000557 Progesterone receptor (1) --------------------------------------------------- Drug1 : DB00294 Etonogestrel Drug2 : DB04573 Estriol Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug1) : BE0000557 Progesterone receptor (1) Non-common off-target(s) (drug2) : BE0000792 Estrogen receptor beta (1) --------------------------------------------------- Drug1 : DB00294 Etonogestrel Drug2 : DB04574 Estropipate Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug1) : BE0000557 Progesterone receptor (1) Non-common off-target(s) (drug2) : BE0000792 Estrogen receptor beta (1) --------------------------------------------------- Drug1 : DB00294 Etonogestrel Drug2 : DB04575 Quinestrol Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug1) : BE0000557 Progesterone receptor (1) --------------------------------------------------- Drug1 : DB00294 Etonogestrel Drug2 : DB06713 Norelgestromin Pharmacological target (+,+) : BE0000557 Progesterone receptor Non-common off-target(s) (drug1) : BE0000123 Estrogen receptor (1) --------------------------------------------------- Drug1 : DB00295 Morphine Drug2 : DB00318 Codeine Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Pharmacological target (+,+) : BE0000632 Kappa-type opioid receptor Pharmacological target (+,+) : BE0000420 Delta-type opioid receptor --------------------------------------------------- Drug1 : DB00295 Morphine Drug2 : DB00327 Hydromorphone Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Pharmacological target (+,+) : BE0000632 Kappa-type opioid receptor Pharmacological target (+,+) : BE0000420 Delta-type opioid receptor --------------------------------------------------- Drug1 : DB00295 Morphine Drug2 : DB00333 Methadone Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Pharmacological target (+,+) : BE0000420 Delta-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (1) Non-common off-target(s) (drug2) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000411 Neuronal acetylcholine receptor subunit alpha-10 (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) --------------------------------------------------- Drug1 : DB00295 Morphine Drug2 : DB00497 Oxycodone Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Pharmacological target (+,+) : BE0000632 Kappa-type opioid receptor Pharmacological target (+,+) : BE0000420 Delta-type opioid receptor Non-common off-target(s) (drug2) : BE0004899 Kappa-type opioid receptor 2b (1) --------------------------------------------------- Drug1 : DB00295 Morphine Drug2 : DB00836 Loperamide Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Pharmacological target (+,+) : BE0000632 Kappa-type opioid receptor Pharmacological target (+,+) : BE0000420 Delta-type opioid receptor Non-common off-target(s) (drug2) : BE0000356 Voltage-dependent P/Q-type calcium channel subunit alpha-1A (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00295 Morphine Drug2 : DB00956 Hydrocodone Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Pharmacological target (+,+) : BE0000420 Delta-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (1) --------------------------------------------------- Drug1 : DB00295 Morphine Drug2 : DB01439 3-Methylthiofentanyl Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Pharmacological target (+,+) : BE0000632 Kappa-type opioid receptor Pharmacological target (+,+) : BE0000420 Delta-type opioid receptor --------------------------------------------------- Drug1 : DB00295 Morphine Drug2 : DB01497 Etorphine Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Pharmacological target (+,+) : BE0000632 Kappa-type opioid receptor Pharmacological target (+,+) : BE0000420 Delta-type opioid receptor Non-common off-target(s) (drug2) : BE0002378 Nociceptin receptor (1) BE0001063 E3 ubiquitin-protein ligase TRIM13 (1) --------------------------------------------------- Drug1 : DB00295 Morphine Drug2 : DB01571 3-Methylfentanyl Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Pharmacological target (+,+) : BE0000632 Kappa-type opioid receptor Pharmacological target (+,+) : BE0000420 Delta-type opioid receptor --------------------------------------------------- Drug1 : DB00295 Morphine Drug2 : DB06738 Ketobemidone Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Pharmacological target (+,+) : BE0000632 Kappa-type opioid receptor Pharmacological target (+,+) : BE0000420 Delta-type opioid receptor Non-common off-target(s) (drug2) : BE0004956 NMDA receptor (-1) --------------------------------------------------- Drug1 : DB00296 Ropivacaine Drug2 : DB00297 Bupivacaine Pharmacological target (-,-) : BE0000177 Sodium channel protein type 10 subunit alpha --------------------------------------------------- Drug1 : DB00296 Ropivacaine Drug2 : DB00527 Cinchocaine Pharmacological target (-,-) : BE0000177 Sodium channel protein type 10 subunit alpha Non-common off-target(s) (drug2) : BE0000197 Sodium channel protein type 5 subunit alpha (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00296 Ropivacaine Drug2 : DB00645 Dyclonine Pharmacological target (-,-) : BE0000177 Sodium channel protein type 10 subunit alpha --------------------------------------------------- Drug1 : DB00296 Ropivacaine Drug2 : DB00807 Proparacaine Pharmacological target (-,-) : BE0000177 Sodium channel protein type 10 subunit alpha --------------------------------------------------- Drug1 : DB00296 Ropivacaine Drug2 : DB00892 Oxybuprocaine Pharmacological target (-,-) : BE0000177 Sodium channel protein type 10 subunit alpha --------------------------------------------------- Drug1 : DB00296 Ropivacaine Drug2 : DB00961 Mepivacaine Pharmacological target (-,-) : BE0000177 Sodium channel protein type 10 subunit alpha --------------------------------------------------- Drug1 : DB00296 Ropivacaine Drug2 : DB01002 Levobupivacaine Pharmacological target (-,-) : BE0000177 Sodium channel protein type 10 subunit alpha --------------------------------------------------- Drug1 : DB00296 Ropivacaine Drug2 : DB01086 Benzocaine Pharmacological target (-,-) : BE0000177 Sodium channel protein type 10 subunit alpha --------------------------------------------------- Drug1 : DB00296 Ropivacaine Drug2 : DB01161 Chloroprocaine Pharmacological target (-,-) : BE0000177 Sodium channel protein type 10 subunit alpha Non-common off-target(s) (drug2) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000411 Neuronal acetylcholine receptor subunit alpha-10 (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) --------------------------------------------------- Drug1 : DB00297 Bupivacaine Drug2 : DB00527 Cinchocaine Pharmacological target (-,-) : BE0000177 Sodium channel protein type 10 subunit alpha Non-common off-target(s) (drug2) : BE0000197 Sodium channel protein type 5 subunit alpha (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00297 Bupivacaine Drug2 : DB00645 Dyclonine Pharmacological target (-,-) : BE0000177 Sodium channel protein type 10 subunit alpha --------------------------------------------------- Drug1 : DB00297 Bupivacaine Drug2 : DB00807 Proparacaine Pharmacological target (-,-) : BE0000177 Sodium channel protein type 10 subunit alpha --------------------------------------------------- Drug1 : DB00297 Bupivacaine Drug2 : DB00892 Oxybuprocaine Pharmacological target (-,-) : BE0000177 Sodium channel protein type 10 subunit alpha --------------------------------------------------- Drug1 : DB00297 Bupivacaine Drug2 : DB00961 Mepivacaine Pharmacological target (-,-) : BE0000177 Sodium channel protein type 10 subunit alpha --------------------------------------------------- Drug1 : DB00297 Bupivacaine Drug2 : DB01002 Levobupivacaine Pharmacological target (-,-) : BE0000177 Sodium channel protein type 10 subunit alpha --------------------------------------------------- Drug1 : DB00297 Bupivacaine Drug2 : DB01086 Benzocaine Pharmacological target (-,-) : BE0000177 Sodium channel protein type 10 subunit alpha --------------------------------------------------- Drug1 : DB00297 Bupivacaine Drug2 : DB01161 Chloroprocaine Pharmacological target (-,-) : BE0000177 Sodium channel protein type 10 subunit alpha Non-common off-target(s) (drug2) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000411 Neuronal acetylcholine receptor subunit alpha-10 (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) --------------------------------------------------- Drug1 : DB00298 Dapiprazole Drug2 : DB00346 Alfuzosin Pharmacological target (-,-) : BE0000501 Alpha-1A adrenergic receptor Pharmacological target (-,-) : BE0000575 Alpha-1B adrenergic receptor Pharmacological target (-,-) : BE0000715 Alpha-1D adrenergic receptor --------------------------------------------------- Drug1 : DB00298 Dapiprazole Drug2 : DB00457 Prazosin Pharmacological target (-,-) : BE0000501 Alpha-1A adrenergic receptor Pharmacological target (-,-) : BE0000575 Alpha-1B adrenergic receptor Pharmacological target (-,-) : BE0000715 Alpha-1D adrenergic receptor Non-common off-target(s) (drug2) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000462 Potassium voltage-gated channel subfamily H member 6 (-1) BE0000699 Potassium voltage-gated channel subfamily H member 7 (-1) --------------------------------------------------- Drug1 : DB00298 Dapiprazole Drug2 : DB00590 Doxazosin Pharmacological target (-,-) : BE0000501 Alpha-1A adrenergic receptor Pharmacological target (-,-) : BE0000575 Alpha-1B adrenergic receptor Pharmacological target (-,-) : BE0000715 Alpha-1D adrenergic receptor Non-common off-target(s) (drug2) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000462 Potassium voltage-gated channel subfamily H member 6 (-1) BE0000699 Potassium voltage-gated channel subfamily H member 7 (-1) --------------------------------------------------- Drug1 : DB00298 Dapiprazole Drug2 : DB01162 Terazosin Pharmacological target (-,-) : BE0000501 Alpha-1A adrenergic receptor Pharmacological target (-,-) : BE0000575 Alpha-1B adrenergic receptor Pharmacological target (-,-) : BE0000715 Alpha-1D adrenergic receptor Non-common off-target(s) (drug2) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000462 Potassium voltage-gated channel subfamily H member 6 (-1) BE0000699 Potassium voltage-gated channel subfamily H member 7 (-1) --------------------------------------------------- Drug1 : DB00302 Tranexamic Acid Drug2 : DB00513 Aminocaproic Acid Pharmacological target (-,-) : BE0000211 Plasminogen Non-common off-target(s) (drug2) : BE0001088 Tissue-type plasminogen activator (-1) --------------------------------------------------- Drug1 : DB00304 Desogestrel Drug2 : DB00351 Megestrol acetate Pharmacological target (+,+) : BE0000557 Progesterone receptor Non-common off-target(s) (drug1) : BE0000123 Estrogen receptor (1) Non-common off-target(s) (drug2) : BE0000794 Glucocorticoid receptor (1) --------------------------------------------------- Drug1 : DB00304 Desogestrel Drug2 : DB00378 Dydrogesterone Pharmacological target (+,+) : BE0000557 Progesterone receptor Non-common off-target(s) (drug1) : BE0000123 Estrogen receptor (1) --------------------------------------------------- Drug1 : DB00304 Desogestrel Drug2 : DB00396 Progesterone Pharmacological target (+,+) : BE0000123 Estrogen receptor Pharmacological target (+,+) : BE0000557 Progesterone receptor Non-common off-target(s) (drug2) : BE0000344 Steroid 17-alpha-hydroxylase/17,20 lyase (-1) BE0000632 Kappa-type opioid receptor (1) BE0000668 Mineralocorticoid receptor (-1) --------------------------------------------------- Drug1 : DB00304 Desogestrel Drug2 : DB00481 Raloxifene Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug1) : BE0000557 Progesterone receptor (1) Non-common off-target(s) (drug2) : BE0000792 Estrogen receptor beta (1) --------------------------------------------------- Drug1 : DB00304 Desogestrel Drug2 : DB00603 Medroxyprogesterone Acetate Pharmacological target (+,+) : BE0000123 Estrogen receptor Pharmacological target (+,+) : BE0000557 Progesterone receptor --------------------------------------------------- Drug1 : DB00304 Desogestrel Drug2 : DB00655 Estrone Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug1) : BE0000557 Progesterone receptor (1) --------------------------------------------------- Drug1 : DB00304 Desogestrel Drug2 : DB00783 Estradiol Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug1) : BE0000557 Progesterone receptor (1) Non-common off-target(s) (drug2) : BE0000792 Estrogen receptor beta (1) --------------------------------------------------- Drug1 : DB00304 Desogestrel Drug2 : DB00823 Ethynodiol Pharmacological target (+,+) : BE0000123 Estrogen receptor Pharmacological target (+,+) : BE0000557 Progesterone receptor --------------------------------------------------- Drug1 : DB00304 Desogestrel Drug2 : DB00890 Dienestrol Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug1) : BE0000557 Progesterone receptor (1) --------------------------------------------------- Drug1 : DB00304 Desogestrel Drug2 : DB00957 Norgestimate Pharmacological target (+,+) : BE0000123 Estrogen receptor Pharmacological target (+,+) : BE0000557 Progesterone receptor --------------------------------------------------- Drug1 : DB00304 Desogestrel Drug2 : DB00977 Ethinyl Estradiol Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug1) : BE0000557 Progesterone receptor (1) Non-common off-target(s) (drug2) : BE0000956 Nuclear receptor subfamily 1 group I member 2 (1) --------------------------------------------------- Drug1 : DB00304 Desogestrel Drug2 : DB01357 Mestranol Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug1) : BE0000557 Progesterone receptor (1) --------------------------------------------------- Drug1 : DB00304 Desogestrel Drug2 : DB04573 Estriol Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug1) : BE0000557 Progesterone receptor (1) Non-common off-target(s) (drug2) : BE0000792 Estrogen receptor beta (1) --------------------------------------------------- Drug1 : DB00304 Desogestrel Drug2 : DB04574 Estropipate Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug1) : BE0000557 Progesterone receptor (1) Non-common off-target(s) (drug2) : BE0000792 Estrogen receptor beta (1) --------------------------------------------------- Drug1 : DB00304 Desogestrel Drug2 : DB04575 Quinestrol Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug1) : BE0000557 Progesterone receptor (1) --------------------------------------------------- Drug1 : DB00304 Desogestrel Drug2 : DB06713 Norelgestromin Pharmacological target (+,+) : BE0000557 Progesterone receptor Non-common off-target(s) (drug1) : BE0000123 Estrogen receptor (1) --------------------------------------------------- Drug1 : DB00305 Mitomycin Drug2 : DB06810 Plicamycin Pharmacological target (-,-) : BE0004796 DNA --------------------------------------------------- Drug1 : DB00306 Talbutal Drug2 : DB00371 Meprobamate Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) --------------------------------------------------- Drug1 : DB00306 Talbutal Drug2 : DB01198 Zopiclone Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0004797 GABA-A receptor (anion channel) (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0000736 Translocator protein (1) --------------------------------------------------- Drug1 : DB00306 Talbutal Drug2 : DB01544 Flunitrazepam Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0004797 GABA-A receptor (anion channel) (1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) Non-common off-target(s) (drug2) : BE0000736 Translocator protein (1) --------------------------------------------------- Drug1 : DB00307 Bexarotene Drug2 : DB00459 Acitretin Pharmacological target (+,+) : BE0000707 Retinoic acid receptor RXR-gamma Pharmacological target (+,+) : BE0000078 Retinoic acid receptor RXR-beta Pharmacological target (+,+) : BE0000412 Retinoic acid receptor RXR-alpha Non-common off-target(s) (drug2) : BE0000301 Retinol-binding protein 1 (1) BE0000144 Retinoic acid receptor gamma (1) BE0000206 Retinoic acid receptor beta (1) BE0000663 Retinoic acid receptor alpha (1) --------------------------------------------------- Drug1 : DB00307 Bexarotene Drug2 : DB00523 Alitretinoin Pharmacological target (+,+) : BE0000707 Retinoic acid receptor RXR-gamma Pharmacological target (+,+) : BE0000078 Retinoic acid receptor RXR-beta Pharmacological target (+,+) : BE0000412 Retinoic acid receptor RXR-alpha Non-common off-target(s) (drug2) : BE0000144 Retinoic acid receptor gamma (1) BE0000206 Retinoic acid receptor beta (1) BE0000663 Retinoic acid receptor alpha (1) --------------------------------------------------- Drug1 : DB00307 Bexarotene Drug2 : DB00755 Tretinoin Pharmacological target (+,+) : BE0000707 Retinoic acid receptor RXR-gamma Pharmacological target (+,+) : BE0000078 Retinoic acid receptor RXR-beta Non-common off-target(s) (drug1) : BE0000412 Retinoic acid receptor RXR-alpha (1) Non-common off-target(s) (drug2) : BE0000144 Retinoic acid receptor gamma (1) BE0000653 Retinoic acid receptor responder protein 1 (1) --------------------------------------------------- Drug1 : DB00307 Bexarotene Drug2 : DB00926 Etretinate Pharmacological target (+,+) : BE0000707 Retinoic acid receptor RXR-gamma Pharmacological target (+,+) : BE0000078 Retinoic acid receptor RXR-beta Pharmacological target (+,+) : BE0000412 Retinoic acid receptor RXR-alpha Non-common off-target(s) (drug2) : BE0000144 Retinoic acid receptor gamma (1) BE0000206 Retinoic acid receptor beta (1) BE0000663 Retinoic acid receptor alpha (1) --------------------------------------------------- Drug1 : DB00309 Vindesine Drug2 : DB01229 Paclitaxel Pharmacological target (-,-) : BE0000026 Tubulin beta-1 chain Non-common off-target(s) (drug2) : BE0000956 Nuclear receptor subfamily 1 group I member 2 (1) BE0000246 Apoptosis regulator Bcl-2 (-1) --------------------------------------------------- Drug1 : DB00309 Vindesine Drug2 : DB01394 Colchicine Pharmacological target (-,-) : BE0000026 Tubulin beta-1 chain Non-common off-target(s) (drug2) : BE0000143 Tubulin beta chain (-1) --------------------------------------------------- Drug1 : DB00310 Chlorthalidone Drug2 : DB00695 Furosemide Pharmacological target (-,-) : BE0000502 Solute carrier family 12 member 1 --------------------------------------------------- Drug1 : DB00310 Chlorthalidone Drug2 : DB00774 Hydroflumethiazide Pharmacological target (-,-) : BE0000502 Solute carrier family 12 member 1 Non-common off-target(s) (drug2) : BE0000267 Carbonic anhydrase 1 (-1) BE0000322 Carbonic anhydrase 2 (-1) BE0000535 Carbonic anhydrase 4 (-1) BE0002437 Carbonic anhydrase 9 (-1) BE0001653 Carbonic anhydrase 12 (-1) --------------------------------------------------- Drug1 : DB00310 Chlorthalidone Drug2 : DB00903 Ethacrynic acid Pharmacological target (-,-) : BE0000502 Solute carrier family 12 member 1 Non-common off-target(s) (drug2) : BE0000732 Sodium/potassium-transporting ATPase subunit alpha-1 (-1) --------------------------------------------------- Drug1 : DB00310 Chlorthalidone Drug2 : DB01021 Trichlormethiazide Pharmacological target (-,-) : BE0000502 Solute carrier family 12 member 1 Non-common off-target(s) (drug2) : BE0000267 Carbonic anhydrase 1 (-1) BE0000322 Carbonic anhydrase 2 (-1) BE0000535 Carbonic anhydrase 4 (-1) BE0000732 Sodium/potassium-transporting ATPase subunit alpha-1 (-1) --------------------------------------------------- Drug1 : DB00311 Ethoxzolamide Drug2 : DB00703 Methazolamide Pharmacological target (-,-) : BE0000267 Carbonic anhydrase 1 Pharmacological target (-,-) : BE0000322 Carbonic anhydrase 2 Pharmacological target (-,-) : BE0000535 Carbonic anhydrase 4 Pharmacological target (-,-) : BE0003629 Carbonic anhydrase 7 --------------------------------------------------- Drug1 : DB00311 Ethoxzolamide Drug2 : DB00819 Acetazolamide Pharmacological target (-,-) : BE0000267 Carbonic anhydrase 1 Pharmacological target (-,-) : BE0000322 Carbonic anhydrase 2 Pharmacological target (-,-) : BE0000535 Carbonic anhydrase 4 Pharmacological target (-,-) : BE0003629 Carbonic anhydrase 7 Non-common off-target(s) (drug2) : BE0003634 Carbonic anhydrase 14 (-1) BE0003625 Carbonic anhydrase 3 (-1) BE0000880 Aquaporin-1 (-1) --------------------------------------------------- Drug1 : DB00311 Ethoxzolamide Drug2 : DB00880 Chlorothiazide Pharmacological target (-,-) : BE0000267 Carbonic anhydrase 1 Pharmacological target (-,-) : BE0000322 Carbonic anhydrase 2 Pharmacological target (-,-) : BE0000535 Carbonic anhydrase 4 Non-common off-target(s) (drug1) : BE0003629 Carbonic anhydrase 7 (-1) Non-common off-target(s) (drug2) : BE0000419 Solute carrier family 12 member 3 (-1) --------------------------------------------------- Drug1 : DB00311 Ethoxzolamide Drug2 : DB01031 Ethinamate Pharmacological target (-,-) : BE0000267 Carbonic anhydrase 1 Pharmacological target (-,-) : BE0000322 Carbonic anhydrase 2 Non-common off-target(s) (drug1) : BE0000535 Carbonic anhydrase 4 (-1) BE0003629 Carbonic anhydrase 7 (-1) --------------------------------------------------- Drug1 : DB00311 Ethoxzolamide Drug2 : DB01119 Diazoxide Pharmacological target (-,-) : BE0000267 Carbonic anhydrase 1 Pharmacological target (-,-) : BE0000322 Carbonic anhydrase 2 Non-common off-target(s) (drug1) : BE0000535 Carbonic anhydrase 4 (-1) BE0003629 Carbonic anhydrase 7 (-1) Non-common off-target(s) (drug2) : BE0000708 ATP-sensitive inward rectifier potassium channel 11 (1) --------------------------------------------------- Drug1 : DB00311 Ethoxzolamide Drug2 : DB01144 Diclofenamide Pharmacological target (-,-) : BE0000267 Carbonic anhydrase 1 Pharmacological target (-,-) : BE0000322 Carbonic anhydrase 2 Pharmacological target (-,-) : BE0000535 Carbonic anhydrase 4 Pharmacological target (-,-) : BE0003629 Carbonic anhydrase 7 --------------------------------------------------- Drug1 : DB00312 Pentobarbital Drug2 : DB00371 Meprobamate Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0004956 NMDA receptor (-1) --------------------------------------------------- Drug1 : DB00312 Pentobarbital Drug2 : DB01198 Zopiclone Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0004797 GABA-A receptor (anion channel) (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0004956 NMDA receptor (-1) Non-common off-target(s) (drug2) : BE0000736 Translocator protein (1) --------------------------------------------------- Drug1 : DB00312 Pentobarbital Drug2 : DB01544 Flunitrazepam Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0004797 GABA-A receptor (anion channel) (1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0004956 NMDA receptor (-1) Non-common off-target(s) (drug2) : BE0000736 Translocator protein (1) --------------------------------------------------- Drug1 : DB00313 Valproic Acid Drug2 : DB01080 Vigabatrin Pharmacological target (-,-) : BE0000253 4-aminobutyrate aminotransferase, mitochondrial Non-common off-target(s) (drug1) : BE0000152 Succinate-semialdehyde dehydrogenase, mitochondrial (-1) BE0000162 2-oxoglutarate dehydrogenase, mitochondrial (-1) BE0000573 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial (-1) BE0000881 Histone deacetylase 9 (-1) Non-common off-target(s) (drug2) : BE0000217 Gamma-aminobutyric acid type B receptor subunit 1 (1) --------------------------------------------------- Drug1 : DB00315 Zolmitriptan Drug2 : DB00320 Dihydroergotamine Pharmacological target (+,+) : BE0000659 5-hydroxytryptamine receptor 1D Pharmacological target (+,+) : BE0000797 5-hydroxytryptamine receptor 1B Non-common off-target(s) (drug1) : BE0000460 5-hydroxytryptamine receptor 1F (1) BE0000291 5-hydroxytryptamine receptor 1A (1) Non-common off-target(s) (drug2) : BE0000393 5-hydroxytryptamine receptor 2B (1) BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00315 Zolmitriptan Drug2 : DB00669 Sumatriptan Pharmacological target (+,+) : BE0000659 5-hydroxytryptamine receptor 1D Pharmacological target (+,+) : BE0000797 5-hydroxytryptamine receptor 1B Pharmacological target (+,+) : BE0000460 5-hydroxytryptamine receptor 1F Pharmacological target (+,+) : BE0000291 5-hydroxytryptamine receptor 1A --------------------------------------------------- Drug1 : DB00315 Zolmitriptan Drug2 : DB00952 Naratriptan Pharmacological target (+,+) : BE0000659 5-hydroxytryptamine receptor 1D Pharmacological target (+,+) : BE0000797 5-hydroxytryptamine receptor 1B Pharmacological target (+,+) : BE0000460 5-hydroxytryptamine receptor 1F Pharmacological target (+,+) : BE0000291 5-hydroxytryptamine receptor 1A --------------------------------------------------- Drug1 : DB00315 Zolmitriptan Drug2 : DB00953 Rizatriptan Pharmacological target (+,+) : BE0000659 5-hydroxytryptamine receptor 1D Pharmacological target (+,+) : BE0000797 5-hydroxytryptamine receptor 1B Pharmacological target (+,+) : BE0000460 5-hydroxytryptamine receptor 1F Non-common off-target(s) (drug1) : BE0000291 5-hydroxytryptamine receptor 1A (1) --------------------------------------------------- Drug1 : DB00315 Zolmitriptan Drug2 : DB00998 Frovatriptan Pharmacological target (+,+) : BE0000659 5-hydroxytryptamine receptor 1D Pharmacological target (+,+) : BE0000797 5-hydroxytryptamine receptor 1B Non-common off-target(s) (drug1) : BE0000460 5-hydroxytryptamine receptor 1F (1) BE0000291 5-hydroxytryptamine receptor 1A (1) --------------------------------------------------- Drug1 : DB00316 Acetaminophen Drug2 : DB00482 Celecoxib Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) Non-common off-target(s) (drug2) : BE0001193 3-phosphoinositide-dependent protein kinase 1 (-1) --------------------------------------------------- Drug1 : DB00316 Acetaminophen Drug2 : DB00533 Rofecoxib Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) --------------------------------------------------- Drug1 : DB00316 Acetaminophen Drug2 : DB00580 Valdecoxib Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) --------------------------------------------------- Drug1 : DB00316 Acetaminophen Drug2 : DB00788 Naproxen Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 --------------------------------------------------- Drug1 : DB00316 Acetaminophen Drug2 : DB00795 Sulfasalazine Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug2) : BE0000030 Cystine/glutamate transporter (-1) BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0000248 Arachidonate 5-lipoxygenase (-1) BE0004655 Inhibitor of nuclear factor kappa-B kinase subunit alpha (-1) BE0001154 Inhibitor of nuclear factor kappa-B kinase subunit beta (-1) BE0000069 Acetyl-CoA acetyltransferase, mitochondrial (-1) BE0001893 Thromboxane-A synthase (-1) BE0003997 Phospholipase A2 (-1) --------------------------------------------------- Drug1 : DB00316 Acetaminophen Drug2 : DB00812 Phenylbutazone Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug2) : BE0000117 Prostacyclin synthase (-1) --------------------------------------------------- Drug1 : DB00316 Acetaminophen Drug2 : DB00870 Suprofen Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 --------------------------------------------------- Drug1 : DB00316 Acetaminophen Drug2 : DB00936 Salicylic acid Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug2) : BE0000126 Aldo-keto reductase family 1 member C1 (-1) --------------------------------------------------- Drug1 : DB00316 Acetaminophen Drug2 : DB00939 Meclofenamic acid Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug2) : BE0000248 Arachidonate 5-lipoxygenase (-1) --------------------------------------------------- Drug1 : DB00316 Acetaminophen Drug2 : DB00945 Acetylsalicylic acid Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug2) : BE0000126 Aldo-keto reductase family 1 member C1 (-1) BE0004907 5'-AMP-activated protein kinase (1) BE0004903 Nuclear factor NF-kappa-B (-1) --------------------------------------------------- Drug1 : DB00316 Acetaminophen Drug2 : DB00991 Oxaprozin Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 --------------------------------------------------- Drug1 : DB00316 Acetaminophen Drug2 : DB01014 Balsalazide Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug2) : BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0000248 Arachidonate 5-lipoxygenase (-1) --------------------------------------------------- Drug1 : DB00316 Acetaminophen Drug2 : DB01050 Ibuprofen Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) Non-common off-target(s) (drug2) : BE0001088 Tissue-type plasminogen activator (-1) BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0001195 Cystic fibrosis transmembrane conductance regulator (-1) --------------------------------------------------- Drug1 : DB00316 Acetaminophen Drug2 : DB01283 Lumiracoxib Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 --------------------------------------------------- Drug1 : DB00316 Acetaminophen Drug2 : DB01397 Magnesium salicylate Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 --------------------------------------------------- Drug1 : DB00316 Acetaminophen Drug2 : DB01398 Salicylate-sodium Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 --------------------------------------------------- Drug1 : DB00316 Acetaminophen Drug2 : DB01399 Salsalate Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 --------------------------------------------------- Drug1 : DB00316 Acetaminophen Drug2 : DB01600 Tiaprofenic acid Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 --------------------------------------------------- Drug1 : DB00316 Acetaminophen Drug2 : DB01628 Etoricoxib Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) --------------------------------------------------- Drug1 : DB00316 Acetaminophen Drug2 : DB04552 Niflumic Acid Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) Non-common off-target(s) (drug2) : BE0003997 Phospholipase A2 (-1) BE0002376 Chloride channel protein ClC-Ka (1) --------------------------------------------------- Drug1 : DB00316 Acetaminophen Drug2 : DB04743 Nimesulide Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) --------------------------------------------------- Drug1 : DB00316 Acetaminophen Drug2 : DB06725 Lornoxicam Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 --------------------------------------------------- Drug1 : DB00317 Gefitinib Drug2 : DB00530 Erlotinib Pharmacological target (-,-) : BE0000767 Epidermal growth factor receptor Non-common off-target(s) (drug2) : BE0000956 Nuclear receptor subfamily 1 group I member 2 (1) --------------------------------------------------- Drug1 : DB00317 Gefitinib Drug2 : DB01259 Lapatinib Pharmacological target (-,-) : BE0000767 Epidermal growth factor receptor Non-common off-target(s) (drug2) : BE0000511 Receptor tyrosine-protein kinase erbB-2 (-1) --------------------------------------------------- Drug1 : DB00317 Gefitinib Drug2 : DB01269 Panitumumab Pharmacological target (-,-) : BE0000767 Epidermal growth factor receptor --------------------------------------------------- Drug1 : DB00318 Codeine Drug2 : DB00327 Hydromorphone Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Pharmacological target (+,+) : BE0000632 Kappa-type opioid receptor Pharmacological target (+,+) : BE0000420 Delta-type opioid receptor --------------------------------------------------- Drug1 : DB00318 Codeine Drug2 : DB00333 Methadone Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Pharmacological target (+,+) : BE0000420 Delta-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (1) Non-common off-target(s) (drug2) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000411 Neuronal acetylcholine receptor subunit alpha-10 (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) --------------------------------------------------- Drug1 : DB00318 Codeine Drug2 : DB00497 Oxycodone Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Pharmacological target (+,+) : BE0000632 Kappa-type opioid receptor Pharmacological target (+,+) : BE0000420 Delta-type opioid receptor Non-common off-target(s) (drug2) : BE0004899 Kappa-type opioid receptor 2b (1) --------------------------------------------------- Drug1 : DB00318 Codeine Drug2 : DB00836 Loperamide Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Pharmacological target (+,+) : BE0000632 Kappa-type opioid receptor Pharmacological target (+,+) : BE0000420 Delta-type opioid receptor Non-common off-target(s) (drug2) : BE0000356 Voltage-dependent P/Q-type calcium channel subunit alpha-1A (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00318 Codeine Drug2 : DB00956 Hydrocodone Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Pharmacological target (+,+) : BE0000420 Delta-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (1) --------------------------------------------------- Drug1 : DB00318 Codeine Drug2 : DB01439 3-Methylthiofentanyl Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Pharmacological target (+,+) : BE0000632 Kappa-type opioid receptor Pharmacological target (+,+) : BE0000420 Delta-type opioid receptor --------------------------------------------------- Drug1 : DB00318 Codeine Drug2 : DB01497 Etorphine Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Pharmacological target (+,+) : BE0000632 Kappa-type opioid receptor Pharmacological target (+,+) : BE0000420 Delta-type opioid receptor Non-common off-target(s) (drug2) : BE0002378 Nociceptin receptor (1) BE0001063 E3 ubiquitin-protein ligase TRIM13 (1) --------------------------------------------------- Drug1 : DB00318 Codeine Drug2 : DB01571 3-Methylfentanyl Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Pharmacological target (+,+) : BE0000632 Kappa-type opioid receptor Pharmacological target (+,+) : BE0000420 Delta-type opioid receptor --------------------------------------------------- Drug1 : DB00318 Codeine Drug2 : DB06738 Ketobemidone Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Pharmacological target (+,+) : BE0000632 Kappa-type opioid receptor Pharmacological target (+,+) : BE0000420 Delta-type opioid receptor Non-common off-target(s) (drug2) : BE0004956 NMDA receptor (-1) --------------------------------------------------- Drug1 : DB00320 Dihydroergotamine Drug2 : DB00669 Sumatriptan Pharmacological target (+,+) : BE0000659 5-hydroxytryptamine receptor 1D Pharmacological target (+,+) : BE0000797 5-hydroxytryptamine receptor 1B Non-common off-target(s) (drug1) : BE0000393 5-hydroxytryptamine receptor 2B (1) BE0000289 Alpha-2A adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000460 5-hydroxytryptamine receptor 1F (1) BE0000291 5-hydroxytryptamine receptor 1A (1) --------------------------------------------------- Drug1 : DB00320 Dihydroergotamine Drug2 : DB00952 Naratriptan Pharmacological target (+,+) : BE0000659 5-hydroxytryptamine receptor 1D Pharmacological target (+,+) : BE0000797 5-hydroxytryptamine receptor 1B Non-common off-target(s) (drug1) : BE0000393 5-hydroxytryptamine receptor 2B (1) BE0000289 Alpha-2A adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000460 5-hydroxytryptamine receptor 1F (1) BE0000291 5-hydroxytryptamine receptor 1A (1) --------------------------------------------------- Drug1 : DB00320 Dihydroergotamine Drug2 : DB00953 Rizatriptan Pharmacological target (+,+) : BE0000659 5-hydroxytryptamine receptor 1D Pharmacological target (+,+) : BE0000797 5-hydroxytryptamine receptor 1B Non-common off-target(s) (drug1) : BE0000393 5-hydroxytryptamine receptor 2B (1) BE0000289 Alpha-2A adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000460 5-hydroxytryptamine receptor 1F (1) --------------------------------------------------- Drug1 : DB00320 Dihydroergotamine Drug2 : DB00998 Frovatriptan Pharmacological target (+,+) : BE0000659 5-hydroxytryptamine receptor 1D Pharmacological target (+,+) : BE0000797 5-hydroxytryptamine receptor 1B Non-common off-target(s) (drug1) : BE0000393 5-hydroxytryptamine receptor 2B (1) BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00321 Amitriptyline Drug2 : DB00344 Protriptyline Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000781 Potassium voltage-gated channel subfamily A member 1 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000112 Histamine H2 receptor (-1) BE0003603 Potassium voltage-gated channel subfamily D member 2 (-1) BE0003604 Potassium voltage-gated channel subfamily D member 3 (-1) BE0001039 High affinity nerve growth factor receptor (1) BE0003605 BDNF/NT-3 growth factors receptor (1) BE0000897 Potassium voltage-gated channel subfamily KQT member 2 (-1) BE0000156 Sigma non-opioid intracellular receptor 1 (1) --------------------------------------------------- Drug1 : DB00321 Amitriptyline Drug2 : DB00476 Duloxetine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000781 Potassium voltage-gated channel subfamily A member 1 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000112 Histamine H2 receptor (-1) BE0003603 Potassium voltage-gated channel subfamily D member 2 (-1) BE0003604 Potassium voltage-gated channel subfamily D member 3 (-1) BE0001039 High affinity nerve growth factor receptor (1) BE0003605 BDNF/NT-3 growth factors receptor (1) BE0000897 Potassium voltage-gated channel subfamily KQT member 2 (-1) BE0000156 Sigma non-opioid intracellular receptor 1 (1) Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB00321 Amitriptyline Drug2 : DB00579 Mazindol Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000781 Potassium voltage-gated channel subfamily A member 1 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000112 Histamine H2 receptor (-1) BE0003603 Potassium voltage-gated channel subfamily D member 2 (-1) BE0003604 Potassium voltage-gated channel subfamily D member 3 (-1) BE0001039 High affinity nerve growth factor receptor (1) BE0003605 BDNF/NT-3 growth factors receptor (1) BE0000897 Potassium voltage-gated channel subfamily KQT member 2 (-1) BE0000156 Sigma non-opioid intracellular receptor 1 (1) Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB00321 Amitriptyline Drug2 : DB01105 Sibutramine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000781 Potassium voltage-gated channel subfamily A member 1 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000112 Histamine H2 receptor (-1) BE0003603 Potassium voltage-gated channel subfamily D member 2 (-1) BE0003604 Potassium voltage-gated channel subfamily D member 3 (-1) BE0001039 High affinity nerve growth factor receptor (1) BE0003605 BDNF/NT-3 growth factors receptor (1) BE0000897 Potassium voltage-gated channel subfamily KQT member 2 (-1) BE0000156 Sigma non-opioid intracellular receptor 1 (1) Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB00321 Amitriptyline Drug2 : DB04896 Milnacipran Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000781 Potassium voltage-gated channel subfamily A member 1 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000112 Histamine H2 receptor (-1) BE0003603 Potassium voltage-gated channel subfamily D member 2 (-1) BE0003604 Potassium voltage-gated channel subfamily D member 3 (-1) BE0001039 High affinity nerve growth factor receptor (1) BE0003605 BDNF/NT-3 growth factors receptor (1) BE0000897 Potassium voltage-gated channel subfamily KQT member 2 (-1) BE0000156 Sigma non-opioid intracellular receptor 1 (1) Non-common off-target(s) (drug2) : BE0004956 NMDA receptor (-1) --------------------------------------------------- Drug1 : DB00321 Amitriptyline Drug2 : DB06700 Desvenlafaxine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000781 Potassium voltage-gated channel subfamily A member 1 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000112 Histamine H2 receptor (-1) BE0003603 Potassium voltage-gated channel subfamily D member 2 (-1) BE0003604 Potassium voltage-gated channel subfamily D member 3 (-1) BE0001039 High affinity nerve growth factor receptor (1) BE0003605 BDNF/NT-3 growth factors receptor (1) BE0000897 Potassium voltage-gated channel subfamily KQT member 2 (-1) BE0000156 Sigma non-opioid intracellular receptor 1 (1) --------------------------------------------------- Drug1 : DB00321 Amitriptyline Drug2 : DB08918 Levomilnacipran Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000781 Potassium voltage-gated channel subfamily A member 1 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000112 Histamine H2 receptor (-1) BE0003603 Potassium voltage-gated channel subfamily D member 2 (-1) BE0003604 Potassium voltage-gated channel subfamily D member 3 (-1) BE0001039 High affinity nerve growth factor receptor (1) BE0003605 BDNF/NT-3 growth factors receptor (1) BE0000897 Potassium voltage-gated channel subfamily KQT member 2 (-1) BE0000156 Sigma non-opioid intracellular receptor 1 (1) --------------------------------------------------- Drug1 : DB00323 Tolcapone Drug2 : DB00494 Entacapone Pharmacological target (-,-) : BE0002089 Catechol O-methyltransferase --------------------------------------------------- Drug1 : DB00324 Fluorometholone Drug2 : DB00394 Beclomethasone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00324 Fluorometholone Drug2 : DB00443 Betamethasone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00324 Fluorometholone Drug2 : DB00547 Desoximetasone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00324 Fluorometholone Drug2 : DB00588 Fluticasone Propionate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug2) : BE0000557 Progesterone receptor (1) BE0000668 Mineralocorticoid receptor (-1) BE0000657 Cytosolic phospholipase A2 (-1) --------------------------------------------------- Drug1 : DB00324 Fluorometholone Drug2 : DB00591 Fluocinolone Acetonide Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00324 Fluorometholone Drug2 : DB00596 Halobetasol Propionate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00324 Fluorometholone Drug2 : DB00620 Triamcinolone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00324 Fluorometholone Drug2 : DB00635 Prednisone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00324 Fluorometholone Drug2 : DB00663 Flumethasone Pivalate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00324 Fluorometholone Drug2 : DB00741 Hydrocortisone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug2) : BE0000422 Annexin A1 (1) --------------------------------------------------- Drug1 : DB00324 Fluorometholone Drug2 : DB00764 Mometasone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00324 Fluorometholone Drug2 : DB00769 Hydrocortamate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00324 Fluorometholone Drug2 : DB00838 Clocortolone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00324 Fluorometholone Drug2 : DB00846 Flurandrenolide Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00324 Fluorometholone Drug2 : DB00860 Prednisolone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00324 Fluorometholone Drug2 : DB00873 Loteprednol Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00324 Fluorometholone Drug2 : DB00896 Rimexolone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00324 Fluorometholone Drug2 : DB00959 Methylprednisolone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00324 Fluorometholone Drug2 : DB01013 Clobetasol propionate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00324 Fluorometholone Drug2 : DB01047 Fluocinonide Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug2) : BE0004659 Smoothened homolog (1) --------------------------------------------------- Drug1 : DB00324 Fluorometholone Drug2 : DB01130 Prednicarbate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00324 Fluorometholone Drug2 : DB01234 Dexamethasone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug2) : BE0000005 Nitric oxide synthase, inducible (-1) BE0000422 Annexin A1 (1) BE0000074 Nuclear receptor subfamily 0 group B member 1 (1) --------------------------------------------------- Drug1 : DB00324 Fluorometholone Drug2 : DB01260 Desonide Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00324 Fluorometholone Drug2 : DB01380 Cortisone acetate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00324 Fluorometholone Drug2 : DB01384 Paramethasone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00324 Fluorometholone Drug2 : DB01410 Ciclesonide Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00324 Fluorometholone Drug2 : DB06781 Difluprednate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00324 Fluorometholone Drug2 : DB08906 Fluticasone furoate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00325 Nitroprusside Drug2 : DB00727 Nitroglycerin Pharmacological target (+,+) : BE0000556 Atrial natriuretic peptide receptor 1 --------------------------------------------------- Drug1 : DB00325 Nitroprusside Drug2 : DB00883 Isosorbide Dinitrate Pharmacological target (+,+) : BE0000556 Atrial natriuretic peptide receptor 1 --------------------------------------------------- Drug1 : DB00325 Nitroprusside Drug2 : DB01612 Amyl Nitrite Pharmacological target (+,+) : BE0000556 Atrial natriuretic peptide receptor 1 --------------------------------------------------- Drug1 : DB00325 Nitroprusside Drug2 : DB01613 Erythrityl Tetranitrate Pharmacological target (+,+) : BE0000556 Atrial natriuretic peptide receptor 1 Non-common off-target(s) (drug2) : BE0000997 Atrial natriuretic peptide receptor 2 (1) --------------------------------------------------- Drug1 : DB00327 Hydromorphone Drug2 : DB00333 Methadone Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Pharmacological target (+,+) : BE0000420 Delta-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (1) Non-common off-target(s) (drug2) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000411 Neuronal acetylcholine receptor subunit alpha-10 (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) --------------------------------------------------- Drug1 : DB00327 Hydromorphone Drug2 : DB00497 Oxycodone Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Pharmacological target (+,+) : BE0000632 Kappa-type opioid receptor Pharmacological target (+,+) : BE0000420 Delta-type opioid receptor Non-common off-target(s) (drug2) : BE0004899 Kappa-type opioid receptor 2b (1) --------------------------------------------------- Drug1 : DB00327 Hydromorphone Drug2 : DB00836 Loperamide Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Pharmacological target (+,+) : BE0000632 Kappa-type opioid receptor Pharmacological target (+,+) : BE0000420 Delta-type opioid receptor Non-common off-target(s) (drug2) : BE0000356 Voltage-dependent P/Q-type calcium channel subunit alpha-1A (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00327 Hydromorphone Drug2 : DB00956 Hydrocodone Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Pharmacological target (+,+) : BE0000420 Delta-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (1) --------------------------------------------------- Drug1 : DB00327 Hydromorphone Drug2 : DB01439 3-Methylthiofentanyl Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Pharmacological target (+,+) : BE0000632 Kappa-type opioid receptor Pharmacological target (+,+) : BE0000420 Delta-type opioid receptor --------------------------------------------------- Drug1 : DB00327 Hydromorphone Drug2 : DB01497 Etorphine Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Pharmacological target (+,+) : BE0000632 Kappa-type opioid receptor Pharmacological target (+,+) : BE0000420 Delta-type opioid receptor Non-common off-target(s) (drug2) : BE0002378 Nociceptin receptor (1) BE0001063 E3 ubiquitin-protein ligase TRIM13 (1) --------------------------------------------------- Drug1 : DB00327 Hydromorphone Drug2 : DB01571 3-Methylfentanyl Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Pharmacological target (+,+) : BE0000632 Kappa-type opioid receptor Pharmacological target (+,+) : BE0000420 Delta-type opioid receptor --------------------------------------------------- Drug1 : DB00327 Hydromorphone Drug2 : DB06738 Ketobemidone Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Pharmacological target (+,+) : BE0000632 Kappa-type opioid receptor Pharmacological target (+,+) : BE0000420 Delta-type opioid receptor Non-common off-target(s) (drug2) : BE0004956 NMDA receptor (-1) --------------------------------------------------- Drug1 : DB00328 Indomethacin Drug2 : DB00482 Celecoxib Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000962 Lactoylglutathione lyase (-1) BE0000017 Prostaglandin G/H synthase 1 (-1) BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0001640 Phospholipase A2, membrane associated (-1) BE0003560 Prostaglandin reductase 2 (-1) BE0000071 Peroxisome proliferator-activated receptor alpha (1) Non-common off-target(s) (drug2) : BE0001193 3-phosphoinositide-dependent protein kinase 1 (-1) --------------------------------------------------- Drug1 : DB00328 Indomethacin Drug2 : DB00533 Rofecoxib Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000962 Lactoylglutathione lyase (-1) BE0000017 Prostaglandin G/H synthase 1 (-1) BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0001640 Phospholipase A2, membrane associated (-1) BE0003560 Prostaglandin reductase 2 (-1) BE0000071 Peroxisome proliferator-activated receptor alpha (1) --------------------------------------------------- Drug1 : DB00328 Indomethacin Drug2 : DB00580 Valdecoxib Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000962 Lactoylglutathione lyase (-1) BE0000017 Prostaglandin G/H synthase 1 (-1) BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0001640 Phospholipase A2, membrane associated (-1) BE0003560 Prostaglandin reductase 2 (-1) BE0000071 Peroxisome proliferator-activated receptor alpha (1) --------------------------------------------------- Drug1 : DB00328 Indomethacin Drug2 : DB01628 Etoricoxib Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000962 Lactoylglutathione lyase (-1) BE0000017 Prostaglandin G/H synthase 1 (-1) BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0001640 Phospholipase A2, membrane associated (-1) BE0003560 Prostaglandin reductase 2 (-1) BE0000071 Peroxisome proliferator-activated receptor alpha (1) --------------------------------------------------- Drug1 : DB00328 Indomethacin Drug2 : DB04552 Niflumic Acid Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000962 Lactoylglutathione lyase (-1) BE0000017 Prostaglandin G/H synthase 1 (-1) BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0001640 Phospholipase A2, membrane associated (-1) BE0003560 Prostaglandin reductase 2 (-1) BE0000071 Peroxisome proliferator-activated receptor alpha (1) Non-common off-target(s) (drug2) : BE0003997 Phospholipase A2 (-1) BE0002376 Chloride channel protein ClC-Ka (1) --------------------------------------------------- Drug1 : DB00328 Indomethacin Drug2 : DB04743 Nimesulide Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000962 Lactoylglutathione lyase (-1) BE0000017 Prostaglandin G/H synthase 1 (-1) BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0001640 Phospholipase A2, membrane associated (-1) BE0003560 Prostaglandin reductase 2 (-1) BE0000071 Peroxisome proliferator-activated receptor alpha (1) --------------------------------------------------- Drug1 : DB00332 Ipratropium bromide Drug2 : DB00383 Oxyphencyclimine Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 --------------------------------------------------- Drug1 : DB00332 Ipratropium bromide Drug2 : DB00387 Procyclidine Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug2) : BE0000405 Muscarinic acetylcholine receptor M4 (-1) --------------------------------------------------- Drug1 : DB00332 Ipratropium bromide Drug2 : DB00505 Tridihexethyl Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 --------------------------------------------------- Drug1 : DB00332 Ipratropium bromide Drug2 : DB00517 Anisotropine Methylbromide Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 --------------------------------------------------- Drug1 : DB00332 Ipratropium bromide Drug2 : DB00572 Atropine Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug2) : BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00332 Ipratropium bromide Drug2 : DB00725 Homatropine Methylbromide Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug2) : BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00332 Ipratropium bromide Drug2 : DB00767 Benzquinamide Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug2) : BE0000442 Histamine H1 receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00332 Ipratropium bromide Drug2 : DB00785 Cryptenamine Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug2) : BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00332 Ipratropium bromide Drug2 : DB01036 Tolterodine Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug2) : BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00332 Ipratropium bromide Drug2 : DB01062 Oxybutynin Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 --------------------------------------------------- Drug1 : DB00332 Ipratropium bromide Drug2 : DB01148 Flavoxate Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) --------------------------------------------------- Drug1 : DB00332 Ipratropium bromide Drug2 : DB01231 Diphenidol Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 --------------------------------------------------- Drug1 : DB00332 Ipratropium bromide Drug2 : DB04843 Mepenzolate Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00332 Ipratropium bromide Drug2 : DB08897 Aclidinium Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug2) : BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00333 Methadone Drug2 : DB00497 Oxycodone Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Pharmacological target (+,+) : BE0000420 Delta-type opioid receptor Non-common off-target(s) (drug1) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000411 Neuronal acetylcholine receptor subunit alpha-10 (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) Non-common off-target(s) (drug2) : BE0000632 Kappa-type opioid receptor (1) BE0004899 Kappa-type opioid receptor 2b (1) --------------------------------------------------- Drug1 : DB00333 Methadone Drug2 : DB00647 Dextropropoxyphene Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Pharmacological target (+,+) : BE0000420 Delta-type opioid receptor Non-common off-target(s) (drug1) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000411 Neuronal acetylcholine receptor subunit alpha-10 (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) Non-common off-target(s) (drug2) : BE0000632 Kappa-type opioid receptor (-1) --------------------------------------------------- Drug1 : DB00333 Methadone Drug2 : DB00813 Fentanyl Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Pharmacological target (+,+) : BE0000420 Delta-type opioid receptor Non-common off-target(s) (drug1) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000411 Neuronal acetylcholine receptor subunit alpha-10 (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) Non-common off-target(s) (drug2) : BE0000632 Kappa-type opioid receptor (1) --------------------------------------------------- Drug1 : DB00333 Methadone Drug2 : DB00836 Loperamide Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Pharmacological target (+,+) : BE0000420 Delta-type opioid receptor Non-common off-target(s) (drug1) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000411 Neuronal acetylcholine receptor subunit alpha-10 (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) Non-common off-target(s) (drug2) : BE0000632 Kappa-type opioid receptor (1) BE0000356 Voltage-dependent P/Q-type calcium channel subunit alpha-1A (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00333 Methadone Drug2 : DB00956 Hydrocodone Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Pharmacological target (+,+) : BE0000420 Delta-type opioid receptor Non-common off-target(s) (drug1) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000411 Neuronal acetylcholine receptor subunit alpha-10 (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) --------------------------------------------------- Drug1 : DB00333 Methadone Drug2 : DB01439 3-Methylthiofentanyl Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Pharmacological target (+,+) : BE0000420 Delta-type opioid receptor Non-common off-target(s) (drug1) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000411 Neuronal acetylcholine receptor subunit alpha-10 (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) Non-common off-target(s) (drug2) : BE0000632 Kappa-type opioid receptor (1) --------------------------------------------------- Drug1 : DB00333 Methadone Drug2 : DB01497 Etorphine Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Pharmacological target (+,+) : BE0000420 Delta-type opioid receptor Non-common off-target(s) (drug1) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000411 Neuronal acetylcholine receptor subunit alpha-10 (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) Non-common off-target(s) (drug2) : BE0000632 Kappa-type opioid receptor (1) BE0002378 Nociceptin receptor (1) BE0001063 E3 ubiquitin-protein ligase TRIM13 (1) --------------------------------------------------- Drug1 : DB00333 Methadone Drug2 : DB01535 Carfentanil Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Pharmacological target (+,+) : BE0000420 Delta-type opioid receptor Non-common off-target(s) (drug1) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000411 Neuronal acetylcholine receptor subunit alpha-10 (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) Non-common off-target(s) (drug2) : BE0000632 Kappa-type opioid receptor (1) --------------------------------------------------- Drug1 : DB00333 Methadone Drug2 : DB01571 3-Methylfentanyl Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Pharmacological target (+,+) : BE0000420 Delta-type opioid receptor Non-common off-target(s) (drug1) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000411 Neuronal acetylcholine receptor subunit alpha-10 (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) Non-common off-target(s) (drug2) : BE0000632 Kappa-type opioid receptor (1) --------------------------------------------------- Drug1 : DB00333 Methadone Drug2 : DB06738 Ketobemidone Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Pharmacological target (+,+) : BE0000420 Delta-type opioid receptor Non-common off-target(s) (drug1) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000411 Neuronal acetylcholine receptor subunit alpha-10 (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) Non-common off-target(s) (drug2) : BE0000632 Kappa-type opioid receptor (1) BE0004956 NMDA receptor (-1) --------------------------------------------------- Drug1 : DB00334 Olanzapine Drug2 : DB00924 Cyclobenzaprine Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000659 5-hydroxytryptamine receptor 1D (-1) BE0000797 5-hydroxytryptamine receptor 1B (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000476 5-hydroxytryptamine receptor 1E (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000145 D(1B) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0004889 D(1) dopamine receptor (-1) BE0000112 Histamine H2 receptor (-1) BE0000146 Histamine H4 receptor (-1) BE0004688 5-hydroxytryptamine receptor 5A (-1) --------------------------------------------------- Drug1 : DB00334 Olanzapine Drug2 : DB00933 Mesoridazine Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000659 5-hydroxytryptamine receptor 1D (-1) BE0000797 5-hydroxytryptamine receptor 1B (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000476 5-hydroxytryptamine receptor 1E (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000145 D(1B) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0004889 D(1) dopamine receptor (-1) BE0000112 Histamine H2 receptor (-1) BE0000146 Histamine H4 receptor (-1) BE0004688 5-hydroxytryptamine receptor 5A (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00335 Atenolol Drug2 : DB00373 Timolol Pharmacological target (-,-) : BE0000172 Beta-1 adrenergic receptor Non-common off-target(s) (drug2) : BE0000694 Beta-2 adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00335 Atenolol Drug2 : DB00571 Propranolol Pharmacological target (-,-) : BE0000172 Beta-1 adrenergic receptor Non-common off-target(s) (drug2) : BE0000694 Beta-2 adrenergic receptor (-1) BE0001012 Beta-3 adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00335 Atenolol Drug2 : DB00612 Bisoprolol Pharmacological target (-,-) : BE0000172 Beta-1 adrenergic receptor Non-common off-target(s) (drug2) : BE0000694 Beta-2 adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00335 Atenolol Drug2 : DB01136 Carvedilol Pharmacological target (-,-) : BE0000172 Beta-1 adrenergic receptor Non-common off-target(s) (drug2) : BE0000173 NADH dehydrogenase [ubiquinone] 1 subunit C2 (-1) BE0000694 Beta-2 adrenergic receptor (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0001114 Vascular cell adhesion protein 1 (-1) BE0001074 E-selectin (-1) --------------------------------------------------- Drug1 : DB00335 Atenolol Drug2 : DB01203 Nadolol Pharmacological target (-,-) : BE0000172 Beta-1 adrenergic receptor Non-common off-target(s) (drug2) : BE0000694 Beta-2 adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00335 Atenolol Drug2 : DB01210 Levobunolol Pharmacological target (-,-) : BE0000172 Beta-1 adrenergic receptor Non-common off-target(s) (drug2) : BE0000694 Beta-2 adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00335 Atenolol Drug2 : DB01214 Metipranolol Pharmacological target (-,-) : BE0000172 Beta-1 adrenergic receptor Non-common off-target(s) (drug2) : BE0000694 Beta-2 adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00335 Atenolol Drug2 : DB01295 Bevantolol Pharmacological target (-,-) : BE0000172 Beta-1 adrenergic receptor Non-common off-target(s) (drug2) : BE0000694 Beta-2 adrenergic receptor (-1) BE0000501 Alpha-1A adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00335 Atenolol Drug2 : DB01297 Practolol Pharmacological target (-,-) : BE0000172 Beta-1 adrenergic receptor --------------------------------------------------- Drug1 : DB00335 Atenolol Drug2 : DB01580 Oxprenolol Pharmacological target (-,-) : BE0000172 Beta-1 adrenergic receptor Non-common off-target(s) (drug2) : BE0000694 Beta-2 adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00335 Atenolol Drug2 : DB04861 Nebivolol Pharmacological target (-,-) : BE0000172 Beta-1 adrenergic receptor Non-common off-target(s) (drug2) : BE0000694 Beta-2 adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00335 Atenolol Drug2 : DB08808 Bupranolol Pharmacological target (-,-) : BE0000172 Beta-1 adrenergic receptor Non-common off-target(s) (drug2) : BE0000694 Beta-2 adrenergic receptor (-1) BE0001012 Beta-3 adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00338 Omeprazole Drug2 : DB00448 Lansoprazole Pharmacological target (-,-) : BE0000349 Potassium-transporting ATPase alpha chain 1 --------------------------------------------------- Drug1 : DB00338 Omeprazole Drug2 : DB00736 Esomeprazole Pharmacological target (-,-) : BE0000349 Potassium-transporting ATPase alpha chain 1 --------------------------------------------------- Drug1 : DB00338 Omeprazole Drug2 : DB01129 Rabeprazole Pharmacological target (-,-) : BE0000349 Potassium-transporting ATPase alpha chain 1 --------------------------------------------------- Drug1 : DB00341 Cetirizine Drug2 : DB00342 Terfenadine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) --------------------------------------------------- Drug1 : DB00341 Cetirizine Drug2 : DB00354 Buclizine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) --------------------------------------------------- Drug1 : DB00341 Cetirizine Drug2 : DB00366 Doxylamine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) --------------------------------------------------- Drug1 : DB00341 Cetirizine Drug2 : DB00405 Dexbrompheniramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00341 Cetirizine Drug2 : DB00427 Triprolidine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00341 Cetirizine Drug2 : DB00455 Loratadine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00341 Cetirizine Drug2 : DB00557 Hydroxyzine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00341 Cetirizine Drug2 : DB00637 Astemizole Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) --------------------------------------------------- Drug1 : DB00341 Cetirizine Drug2 : DB00719 Azatadine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00341 Cetirizine Drug2 : DB00737 Meclizine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00341 Cetirizine Drug2 : DB00748 Carbinoxamine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00341 Cetirizine Drug2 : DB00751 Epinastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000112 Histamine H2 receptor (-1) --------------------------------------------------- Drug1 : DB00341 Cetirizine Drug2 : DB00768 Olopatadine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0001090 Protein S100-A1 (-1) BE0001206 Protein S100-A12 (-1) BE0003602 Protein S100-A2 (-1) --------------------------------------------------- Drug1 : DB00341 Cetirizine Drug2 : DB00777 Propiomazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00341 Cetirizine Drug2 : DB00792 Tripelennamine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00341 Cetirizine Drug2 : DB00835 Brompheniramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00341 Cetirizine Drug2 : DB00902 Methdilazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00341 Cetirizine Drug2 : DB00950 Fexofenadine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00341 Cetirizine Drug2 : DB00967 Desloratadine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00341 Cetirizine Drug2 : DB00972 Azelastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00341 Cetirizine Drug2 : DB00985 Dimenhydrinate Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00341 Cetirizine Drug2 : DB01069 Promethazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00341 Cetirizine Drug2 : DB01071 Mequitazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00341 Cetirizine Drug2 : DB01075 Diphenhydramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00341 Cetirizine Drug2 : DB01084 Emedastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00341 Cetirizine Drug2 : DB01106 Levocabastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000464 Neurotensin receptor type 2 (-1) --------------------------------------------------- Drug1 : DB00341 Cetirizine Drug2 : DB01114 Chlorphenamine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB00341 Cetirizine Drug2 : DB01146 Diphenylpyraline Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB00341 Cetirizine Drug2 : DB01176 Cyclizine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000951 Estrogen sulfotransferase (-1) --------------------------------------------------- Drug1 : DB00341 Cetirizine Drug2 : DB01237 Bromodiphenhydramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00341 Cetirizine Drug2 : DB01246 Alimemazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00341 Cetirizine Drug2 : DB01615 Aceprometazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00341 Cetirizine Drug2 : DB01619 Phenindamine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00341 Cetirizine Drug2 : DB01620 Pheniramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00341 Cetirizine Drug2 : DB04837 Clofedanol Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00341 Cetirizine Drug2 : DB04890 Bepotastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00341 Cetirizine Drug2 : DB06691 Mepyramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00341 Cetirizine Drug2 : DB08799 Antazoline Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00341 Cetirizine Drug2 : DB08800 Chloropyramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00341 Cetirizine Drug2 : DB08801 Dimetindene Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00341 Cetirizine Drug2 : DB08802 Isothipendyl Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00341 Cetirizine Drug2 : DB08936 Chlorcyclizine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00342 Terfenadine Drug2 : DB00354 Buclizine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) Non-common off-target(s) (drug2) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) --------------------------------------------------- Drug1 : DB00342 Terfenadine Drug2 : DB00366 Doxylamine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) Non-common off-target(s) (drug2) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) --------------------------------------------------- Drug1 : DB00342 Terfenadine Drug2 : DB00405 Dexbrompheniramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) --------------------------------------------------- Drug1 : DB00342 Terfenadine Drug2 : DB00427 Triprolidine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) --------------------------------------------------- Drug1 : DB00342 Terfenadine Drug2 : DB00455 Loratadine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) --------------------------------------------------- Drug1 : DB00342 Terfenadine Drug2 : DB00557 Hydroxyzine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) --------------------------------------------------- Drug1 : DB00342 Terfenadine Drug2 : DB00719 Azatadine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) --------------------------------------------------- Drug1 : DB00342 Terfenadine Drug2 : DB00737 Meclizine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) --------------------------------------------------- Drug1 : DB00342 Terfenadine Drug2 : DB00748 Carbinoxamine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) --------------------------------------------------- Drug1 : DB00342 Terfenadine Drug2 : DB00751 Epinastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) Non-common off-target(s) (drug2) : BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000112 Histamine H2 receptor (-1) --------------------------------------------------- Drug1 : DB00342 Terfenadine Drug2 : DB00768 Olopatadine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) Non-common off-target(s) (drug2) : BE0001090 Protein S100-A1 (-1) BE0001206 Protein S100-A12 (-1) BE0003602 Protein S100-A2 (-1) --------------------------------------------------- Drug1 : DB00342 Terfenadine Drug2 : DB00792 Tripelennamine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) --------------------------------------------------- Drug1 : DB00342 Terfenadine Drug2 : DB00902 Methdilazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) --------------------------------------------------- Drug1 : DB00342 Terfenadine Drug2 : DB00950 Fexofenadine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) --------------------------------------------------- Drug1 : DB00342 Terfenadine Drug2 : DB00967 Desloratadine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) --------------------------------------------------- Drug1 : DB00342 Terfenadine Drug2 : DB00972 Azelastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) --------------------------------------------------- Drug1 : DB00342 Terfenadine Drug2 : DB00985 Dimenhydrinate Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) --------------------------------------------------- Drug1 : DB00342 Terfenadine Drug2 : DB01071 Mequitazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) --------------------------------------------------- Drug1 : DB00342 Terfenadine Drug2 : DB01075 Diphenhydramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) --------------------------------------------------- Drug1 : DB00342 Terfenadine Drug2 : DB01084 Emedastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) --------------------------------------------------- Drug1 : DB00342 Terfenadine Drug2 : DB01106 Levocabastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) Non-common off-target(s) (drug2) : BE0000464 Neurotensin receptor type 2 (-1) --------------------------------------------------- Drug1 : DB00342 Terfenadine Drug2 : DB01114 Chlorphenamine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB00342 Terfenadine Drug2 : DB01146 Diphenylpyraline Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB00342 Terfenadine Drug2 : DB01176 Cyclizine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) Non-common off-target(s) (drug2) : BE0000951 Estrogen sulfotransferase (-1) --------------------------------------------------- Drug1 : DB00342 Terfenadine Drug2 : DB01237 Bromodiphenhydramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) --------------------------------------------------- Drug1 : DB00342 Terfenadine Drug2 : DB01246 Alimemazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) --------------------------------------------------- Drug1 : DB00342 Terfenadine Drug2 : DB01615 Aceprometazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) --------------------------------------------------- Drug1 : DB00342 Terfenadine Drug2 : DB01619 Phenindamine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) --------------------------------------------------- Drug1 : DB00342 Terfenadine Drug2 : DB01620 Pheniramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) --------------------------------------------------- Drug1 : DB00342 Terfenadine Drug2 : DB04837 Clofedanol Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) --------------------------------------------------- Drug1 : DB00342 Terfenadine Drug2 : DB04890 Bepotastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) --------------------------------------------------- Drug1 : DB00342 Terfenadine Drug2 : DB06691 Mepyramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) --------------------------------------------------- Drug1 : DB00342 Terfenadine Drug2 : DB08799 Antazoline Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) --------------------------------------------------- Drug1 : DB00342 Terfenadine Drug2 : DB08800 Chloropyramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) --------------------------------------------------- Drug1 : DB00342 Terfenadine Drug2 : DB08801 Dimetindene Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) Non-common off-target(s) (drug2) : BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00342 Terfenadine Drug2 : DB08802 Isothipendyl Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) --------------------------------------------------- Drug1 : DB00342 Terfenadine Drug2 : DB08936 Chlorcyclizine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) --------------------------------------------------- Drug1 : DB00343 Diltiazem Drug2 : DB00528 Lercanidipine Pharmacological target (-,-) : BE0000679 Voltage-dependent calcium channel gamma-1 subunit --------------------------------------------------- Drug1 : DB00344 Protriptyline Drug2 : DB00458 Imipramine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0003603 Potassium voltage-gated channel subfamily D member 2 (-1) BE0003604 Potassium voltage-gated channel subfamily D member 3 (-1) --------------------------------------------------- Drug1 : DB00344 Protriptyline Drug2 : DB00472 Fluoxetine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug1) : BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB00344 Protriptyline Drug2 : DB00476 Duloxetine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB00344 Protriptyline Drug2 : DB00540 Nortriptyline Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug2) : BE0004872 Beta adrenergic receptor (-1) BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0004864 Alpha-2 adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00344 Protriptyline Drug2 : DB00579 Mazindol Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB00344 Protriptyline Drug2 : DB00726 Trimipramine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (1) BE0000289 Alpha-2A adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00344 Protriptyline Drug2 : DB00830 Phenmetrazine Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB00344 Protriptyline Drug2 : DB00907 Cocaine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000197 Sodium channel protein type 5 subunit alpha (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) BE0000192 Sodium channel protein type 11 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00344 Protriptyline Drug2 : DB00934 Maprotiline Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000442 Histamine H1 receptor (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0004864 Alpha-2 adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0004863 Alpha-1 adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00344 Protriptyline Drug2 : DB00937 Diethylpropion Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB00344 Protriptyline Drug2 : DB01104 Sertraline Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug1) : BE0000486 Sodium-dependent noradrenaline transporter (-1) Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB00344 Protriptyline Drug2 : DB01105 Sibutramine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB00344 Protriptyline Drug2 : DB01151 Desipramine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000694 Beta-2 adrenergic receptor (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000442 Histamine H1 receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0004863 Alpha-1 adrenergic receptor (-1) BE0000973 Sphingomyelin phosphodiesterase (-1) --------------------------------------------------- Drug1 : DB00344 Protriptyline Drug2 : DB01156 Bupropion Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0003585 Neuronal acetylcholine receptor subunit alpha-3 (-1) --------------------------------------------------- Drug1 : DB00344 Protriptyline Drug2 : DB01191 Dexfenfluramine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug1) : BE0000486 Sodium-dependent noradrenaline transporter (-1) Non-common off-target(s) (drug2) : BE0000533 5-hydroxytryptamine receptor 2C (1) --------------------------------------------------- Drug1 : DB00344 Protriptyline Drug2 : DB01454 3,4-Methylenedioxymethamphetamine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000533 5-hydroxytryptamine receptor 2C (1) BE0000393 5-hydroxytryptamine receptor 2B (1) BE0000451 5-hydroxytryptamine receptor 2A (1) --------------------------------------------------- Drug1 : DB00344 Protriptyline Drug2 : DB01579 Phendimetrazine Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00344 Protriptyline Drug2 : DB04896 Milnacipran Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug2) : BE0004956 NMDA receptor (-1) --------------------------------------------------- Drug1 : DB00344 Protriptyline Drug2 : DB06700 Desvenlafaxine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter --------------------------------------------------- Drug1 : DB00344 Protriptyline Drug2 : DB08918 Levomilnacipran Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter --------------------------------------------------- Drug1 : DB00346 Alfuzosin Drug2 : DB00457 Prazosin Pharmacological target (-,-) : BE0000501 Alpha-1A adrenergic receptor Pharmacological target (-,-) : BE0000575 Alpha-1B adrenergic receptor Pharmacological target (-,-) : BE0000715 Alpha-1D adrenergic receptor Non-common off-target(s) (drug2) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000462 Potassium voltage-gated channel subfamily H member 6 (-1) BE0000699 Potassium voltage-gated channel subfamily H member 7 (-1) --------------------------------------------------- Drug1 : DB00346 Alfuzosin Drug2 : DB00590 Doxazosin Pharmacological target (-,-) : BE0000501 Alpha-1A adrenergic receptor Pharmacological target (-,-) : BE0000575 Alpha-1B adrenergic receptor Pharmacological target (-,-) : BE0000715 Alpha-1D adrenergic receptor Non-common off-target(s) (drug2) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000462 Potassium voltage-gated channel subfamily H member 6 (-1) BE0000699 Potassium voltage-gated channel subfamily H member 7 (-1) --------------------------------------------------- Drug1 : DB00346 Alfuzosin Drug2 : DB01162 Terazosin Pharmacological target (-,-) : BE0000501 Alpha-1A adrenergic receptor Pharmacological target (-,-) : BE0000575 Alpha-1B adrenergic receptor Pharmacological target (-,-) : BE0000715 Alpha-1D adrenergic receptor Non-common off-target(s) (drug2) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000462 Potassium voltage-gated channel subfamily H member 6 (-1) BE0000699 Potassium voltage-gated channel subfamily H member 7 (-1) --------------------------------------------------- Drug1 : DB00347 Trimethadione Drug2 : DB00593 Ethosuximide Pharmacological target (-,-) : BE0000483 Voltage-dependent T-type calcium channel subunit alpha-1G --------------------------------------------------- Drug1 : DB00347 Trimethadione Drug2 : DB05246 Methsuximide Pharmacological target (-,-) : BE0000483 Voltage-dependent T-type calcium channel subunit alpha-1G --------------------------------------------------- Drug1 : DB00349 Clobazam Drug2 : DB00404 Alprazolam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) --------------------------------------------------- Drug1 : DB00349 Clobazam Drug2 : DB00475 Chlordiazepoxide Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) --------------------------------------------------- Drug1 : DB00349 Clobazam Drug2 : DB00628 Clorazepate Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug2) : BE0000736 Translocator protein (1) --------------------------------------------------- Drug1 : DB00349 Clobazam Drug2 : DB01068 Clonazepam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) --------------------------------------------------- Drug1 : DB00349 Clobazam Drug2 : DB01107 Methyprylon Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug2) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) --------------------------------------------------- Drug1 : DB00349 Clobazam Drug2 : DB01159 Halothane Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug2) : BE0000534 Glutamate receptor ionotropic, NMDA 3B (-1) BE0000760 Glutamate receptor ionotropic, NMDA 2A (-1) BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000503 NADH-ubiquinone oxidoreductase chain 1 (-1) BE0000415 Intermediate conductance calcium-activated potassium channel protein 4 (-1) BE0000553 Calcium-activated potassium channel subunit alpha-1 (-1) BE0001028 G protein-activated inward rectifier potassium channel 1 (-1) BE0001030 G protein-activated inward rectifier potassium channel 2 (-1) --------------------------------------------------- Drug1 : DB00349 Clobazam Drug2 : DB01437 Glutethimide Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug2) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) --------------------------------------------------- Drug1 : DB00351 Megestrol acetate Drug2 : DB00378 Dydrogesterone Pharmacological target (+,+) : BE0000557 Progesterone receptor Non-common off-target(s) (drug1) : BE0000794 Glucocorticoid receptor (1) --------------------------------------------------- Drug1 : DB00351 Megestrol acetate Drug2 : DB00603 Medroxyprogesterone Acetate Pharmacological target (+,+) : BE0000557 Progesterone receptor Non-common off-target(s) (drug1) : BE0000794 Glucocorticoid receptor (1) Non-common off-target(s) (drug2) : BE0000123 Estrogen receptor (1) --------------------------------------------------- Drug1 : DB00351 Megestrol acetate Drug2 : DB00823 Ethynodiol Pharmacological target (+,+) : BE0000557 Progesterone receptor Non-common off-target(s) (drug1) : BE0000794 Glucocorticoid receptor (1) Non-common off-target(s) (drug2) : BE0000123 Estrogen receptor (1) --------------------------------------------------- Drug1 : DB00351 Megestrol acetate Drug2 : DB00957 Norgestimate Pharmacological target (+,+) : BE0000557 Progesterone receptor Non-common off-target(s) (drug1) : BE0000794 Glucocorticoid receptor (1) Non-common off-target(s) (drug2) : BE0000123 Estrogen receptor (1) --------------------------------------------------- Drug1 : DB00351 Megestrol acetate Drug2 : DB01431 Allylestrenol Pharmacological target (+,+) : BE0000557 Progesterone receptor Non-common off-target(s) (drug1) : BE0000794 Glucocorticoid receptor (1) Non-common off-target(s) (drug2) : BE0000123 Estrogen receptor (1) --------------------------------------------------- Drug1 : DB00351 Megestrol acetate Drug2 : DB06713 Norelgestromin Pharmacological target (+,+) : BE0000557 Progesterone receptor Non-common off-target(s) (drug1) : BE0000794 Glucocorticoid receptor (1) --------------------------------------------------- Drug1 : DB00353 Methylergometrine Drug2 : DB00623 Fluphenazine Pharmacological target (-,-) : BE0000020 D(1A) dopamine receptor Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00353 Methylergometrine Drug2 : DB00850 Perphenazine Pharmacological target (-,-) : BE0000020 D(1A) dopamine receptor Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00353 Methylergometrine Drug2 : DB01063 Acetophenazine Pharmacological target (-,-) : BE0000020 D(1A) dopamine receptor Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00353 Methylergometrine Drug2 : DB01608 Propericiazine Pharmacological target (-,-) : BE0000020 D(1A) dopamine receptor Non-common off-target(s) (drug2) : BE0000575 Alpha-1B adrenergic receptor (-1) BE0000289 Alpha-2A adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00354 Buclizine Drug2 : DB00376 Trihexyphenidyl Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000442 Histamine H1 receptor (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00354 Buclizine Drug2 : DB00392 Ethopropazine Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000442 Histamine H1 receptor (-1) Non-common off-target(s) (drug2) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00354 Buclizine Drug2 : DB00405 Dexbrompheniramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) --------------------------------------------------- Drug1 : DB00354 Buclizine Drug2 : DB00424 Hyoscyamine Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000442 Histamine H1 receptor (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) --------------------------------------------------- Drug1 : DB00354 Buclizine Drug2 : DB00427 Triprolidine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) --------------------------------------------------- Drug1 : DB00354 Buclizine Drug2 : DB00455 Loratadine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) --------------------------------------------------- Drug1 : DB00354 Buclizine Drug2 : DB00462 Methylscopolamine bromide Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000442 Histamine H1 receptor (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00354 Buclizine Drug2 : DB00557 Hydroxyzine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) --------------------------------------------------- Drug1 : DB00354 Buclizine Drug2 : DB00637 Astemizole Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) Non-common off-target(s) (drug2) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) --------------------------------------------------- Drug1 : DB00354 Buclizine Drug2 : DB00670 Pirenzepine Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000442 Histamine H1 receptor (-1) --------------------------------------------------- Drug1 : DB00354 Buclizine Drug2 : DB00719 Azatadine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) --------------------------------------------------- Drug1 : DB00354 Buclizine Drug2 : DB00737 Meclizine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) --------------------------------------------------- Drug1 : DB00354 Buclizine Drug2 : DB00747 Scopolamine Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000442 Histamine H1 receptor (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0001176 Sucrase-isomaltase, intestinal (-1) --------------------------------------------------- Drug1 : DB00354 Buclizine Drug2 : DB00748 Carbinoxamine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) --------------------------------------------------- Drug1 : DB00354 Buclizine Drug2 : DB00751 Epinastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) Non-common off-target(s) (drug2) : BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000112 Histamine H2 receptor (-1) --------------------------------------------------- Drug1 : DB00354 Buclizine Drug2 : DB00768 Olopatadine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) Non-common off-target(s) (drug2) : BE0001090 Protein S100-A1 (-1) BE0001206 Protein S100-A12 (-1) BE0003602 Protein S100-A2 (-1) --------------------------------------------------- Drug1 : DB00354 Buclizine Drug2 : DB00771 Clidinium Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000442 Histamine H1 receptor (-1) --------------------------------------------------- Drug1 : DB00354 Buclizine Drug2 : DB00782 Propantheline Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000442 Histamine H1 receptor (-1) --------------------------------------------------- Drug1 : DB00354 Buclizine Drug2 : DB00792 Tripelennamine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) --------------------------------------------------- Drug1 : DB00354 Buclizine Drug2 : DB00804 Dicyclomine Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000442 Histamine H1 receptor (-1) Non-common off-target(s) (drug2) : BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00354 Buclizine Drug2 : DB00810 Biperiden Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000442 Histamine H1 receptor (-1) Non-common off-target(s) (drug2) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) --------------------------------------------------- Drug1 : DB00354 Buclizine Drug2 : DB00902 Methdilazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) --------------------------------------------------- Drug1 : DB00354 Buclizine Drug2 : DB00942 Cycrimine Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000442 Histamine H1 receptor (-1) --------------------------------------------------- Drug1 : DB00354 Buclizine Drug2 : DB00950 Fexofenadine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) --------------------------------------------------- Drug1 : DB00354 Buclizine Drug2 : DB00967 Desloratadine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) --------------------------------------------------- Drug1 : DB00354 Buclizine Drug2 : DB00972 Azelastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) --------------------------------------------------- Drug1 : DB00354 Buclizine Drug2 : DB00979 Cyclopentolate Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000442 Histamine H1 receptor (-1) --------------------------------------------------- Drug1 : DB00354 Buclizine Drug2 : DB00985 Dimenhydrinate Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) --------------------------------------------------- Drug1 : DB00354 Buclizine Drug2 : DB00986 Glycopyrrolate Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000442 Histamine H1 receptor (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) --------------------------------------------------- Drug1 : DB00354 Buclizine Drug2 : DB01071 Mequitazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) --------------------------------------------------- Drug1 : DB00354 Buclizine Drug2 : DB01075 Diphenhydramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) --------------------------------------------------- Drug1 : DB00354 Buclizine Drug2 : DB01084 Emedastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) --------------------------------------------------- Drug1 : DB00354 Buclizine Drug2 : DB01106 Levocabastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) Non-common off-target(s) (drug2) : BE0000464 Neurotensin receptor type 2 (-1) --------------------------------------------------- Drug1 : DB00354 Buclizine Drug2 : DB01114 Chlorphenamine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB00354 Buclizine Drug2 : DB01146 Diphenylpyraline Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB00354 Buclizine Drug2 : DB01148 Flavoxate Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000442 Histamine H1 receptor (-1) Non-common off-target(s) (drug2) : BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00354 Buclizine Drug2 : DB01176 Cyclizine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) Non-common off-target(s) (drug2) : BE0000951 Estrogen sulfotransferase (-1) --------------------------------------------------- Drug1 : DB00354 Buclizine Drug2 : DB01237 Bromodiphenhydramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) --------------------------------------------------- Drug1 : DB00354 Buclizine Drug2 : DB01246 Alimemazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) --------------------------------------------------- Drug1 : DB00354 Buclizine Drug2 : DB01615 Aceprometazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) --------------------------------------------------- Drug1 : DB00354 Buclizine Drug2 : DB01619 Phenindamine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) --------------------------------------------------- Drug1 : DB00354 Buclizine Drug2 : DB01620 Pheniramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) --------------------------------------------------- Drug1 : DB00354 Buclizine Drug2 : DB04837 Clofedanol Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) --------------------------------------------------- Drug1 : DB00354 Buclizine Drug2 : DB04843 Mepenzolate Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000442 Histamine H1 receptor (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) --------------------------------------------------- Drug1 : DB00354 Buclizine Drug2 : DB04890 Bepotastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) --------------------------------------------------- Drug1 : DB00354 Buclizine Drug2 : DB06691 Mepyramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) --------------------------------------------------- Drug1 : DB00354 Buclizine Drug2 : DB08799 Antazoline Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) --------------------------------------------------- Drug1 : DB00354 Buclizine Drug2 : DB08800 Chloropyramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) --------------------------------------------------- Drug1 : DB00354 Buclizine Drug2 : DB08801 Dimetindene Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) Non-common off-target(s) (drug2) : BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00354 Buclizine Drug2 : DB08802 Isothipendyl Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) --------------------------------------------------- Drug1 : DB00354 Buclizine Drug2 : DB08936 Chlorcyclizine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) --------------------------------------------------- Drug1 : DB00357 Aminoglutethimide Drug2 : DB00894 Testolactone Pharmacological target (-,-) : BE0002090 Cytochrome P450 19A1 Non-common off-target(s) (drug1) : BE0003537 Cholesterol side-chain cleavage enzyme, mitochondrial (-1) --------------------------------------------------- Drug1 : DB00357 Aminoglutethimide Drug2 : DB00990 Exemestane Pharmacological target (-,-) : BE0002090 Cytochrome P450 19A1 Non-common off-target(s) (drug1) : BE0003537 Cholesterol side-chain cleavage enzyme, mitochondrial (-1) --------------------------------------------------- Drug1 : DB00357 Aminoglutethimide Drug2 : DB01006 Letrozole Pharmacological target (-,-) : BE0002090 Cytochrome P450 19A1 Non-common off-target(s) (drug1) : BE0003537 Cholesterol side-chain cleavage enzyme, mitochondrial (-1) --------------------------------------------------- Drug1 : DB00357 Aminoglutethimide Drug2 : DB01217 Anastrozole Pharmacological target (-,-) : BE0002090 Cytochrome P450 19A1 Non-common off-target(s) (drug1) : BE0003537 Cholesterol side-chain cleavage enzyme, mitochondrial (-1) --------------------------------------------------- Drug1 : DB00361 Vinorelbine Drug2 : DB00541 Vincristine Pharmacological target (-,-) : BE0000143 Tubulin beta chain Non-common off-target(s) (drug2) : BE0001391 Tubulin alpha-4A chain (-1) --------------------------------------------------- Drug1 : DB00361 Vinorelbine Drug2 : DB01394 Colchicine Pharmacological target (-,-) : BE0000143 Tubulin beta chain Non-common off-target(s) (drug2) : BE0000026 Tubulin beta-1 chain (-1) --------------------------------------------------- Drug1 : DB00363 Clozapine Drug2 : DB00433 Prochlorperazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000659 5-hydroxytryptamine receptor 1D (-1) BE0000797 5-hydroxytryptamine receptor 1B (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000476 5-hydroxytryptamine receptor 1E (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000146 Histamine H4 receptor (-1) --------------------------------------------------- Drug1 : DB00363 Clozapine Drug2 : DB00924 Cyclobenzaprine Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000659 5-hydroxytryptamine receptor 1D (-1) BE0000797 5-hydroxytryptamine receptor 1B (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000476 5-hydroxytryptamine receptor 1E (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000146 Histamine H4 receptor (-1) --------------------------------------------------- Drug1 : DB00363 Clozapine Drug2 : DB00933 Mesoridazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000659 5-hydroxytryptamine receptor 1D (-1) BE0000797 5-hydroxytryptamine receptor 1B (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000476 5-hydroxytryptamine receptor 1E (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000146 Histamine H4 receptor (-1) --------------------------------------------------- Drug1 : DB00363 Clozapine Drug2 : DB01425 Alizapride Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000659 5-hydroxytryptamine receptor 1D (-1) BE0000797 5-hydroxytryptamine receptor 1B (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000476 5-hydroxytryptamine receptor 1E (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000146 Histamine H4 receptor (-1) --------------------------------------------------- Drug1 : DB00363 Clozapine Drug2 : DB09018 Bromopride Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000659 5-hydroxytryptamine receptor 1D (-1) BE0000797 5-hydroxytryptamine receptor 1B (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000476 5-hydroxytryptamine receptor 1E (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000146 Histamine H4 receptor (-1) --------------------------------------------------- Drug1 : DB00366 Doxylamine Drug2 : DB00405 Dexbrompheniramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) --------------------------------------------------- Drug1 : DB00366 Doxylamine Drug2 : DB00427 Triprolidine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) --------------------------------------------------- Drug1 : DB00366 Doxylamine Drug2 : DB00455 Loratadine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) --------------------------------------------------- Drug1 : DB00366 Doxylamine Drug2 : DB00557 Hydroxyzine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) --------------------------------------------------- Drug1 : DB00366 Doxylamine Drug2 : DB00637 Astemizole Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) Non-common off-target(s) (drug2) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) --------------------------------------------------- Drug1 : DB00366 Doxylamine Drug2 : DB00719 Azatadine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) --------------------------------------------------- Drug1 : DB00366 Doxylamine Drug2 : DB00737 Meclizine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) --------------------------------------------------- Drug1 : DB00366 Doxylamine Drug2 : DB00748 Carbinoxamine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) --------------------------------------------------- Drug1 : DB00366 Doxylamine Drug2 : DB00751 Epinastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) Non-common off-target(s) (drug2) : BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000112 Histamine H2 receptor (-1) --------------------------------------------------- Drug1 : DB00366 Doxylamine Drug2 : DB00768 Olopatadine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) Non-common off-target(s) (drug2) : BE0001090 Protein S100-A1 (-1) BE0001206 Protein S100-A12 (-1) BE0003602 Protein S100-A2 (-1) --------------------------------------------------- Drug1 : DB00366 Doxylamine Drug2 : DB00792 Tripelennamine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) --------------------------------------------------- Drug1 : DB00366 Doxylamine Drug2 : DB00902 Methdilazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) --------------------------------------------------- Drug1 : DB00366 Doxylamine Drug2 : DB00950 Fexofenadine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) --------------------------------------------------- Drug1 : DB00366 Doxylamine Drug2 : DB00967 Desloratadine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) --------------------------------------------------- Drug1 : DB00366 Doxylamine Drug2 : DB00972 Azelastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) --------------------------------------------------- Drug1 : DB00366 Doxylamine Drug2 : DB00985 Dimenhydrinate Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) --------------------------------------------------- Drug1 : DB00366 Doxylamine Drug2 : DB01071 Mequitazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) --------------------------------------------------- Drug1 : DB00366 Doxylamine Drug2 : DB01075 Diphenhydramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) --------------------------------------------------- Drug1 : DB00366 Doxylamine Drug2 : DB01084 Emedastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) --------------------------------------------------- Drug1 : DB00366 Doxylamine Drug2 : DB01106 Levocabastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) Non-common off-target(s) (drug2) : BE0000464 Neurotensin receptor type 2 (-1) --------------------------------------------------- Drug1 : DB00366 Doxylamine Drug2 : DB01114 Chlorphenamine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB00366 Doxylamine Drug2 : DB01146 Diphenylpyraline Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB00366 Doxylamine Drug2 : DB01176 Cyclizine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) Non-common off-target(s) (drug2) : BE0000951 Estrogen sulfotransferase (-1) --------------------------------------------------- Drug1 : DB00366 Doxylamine Drug2 : DB01237 Bromodiphenhydramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) --------------------------------------------------- Drug1 : DB00366 Doxylamine Drug2 : DB01246 Alimemazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) --------------------------------------------------- Drug1 : DB00366 Doxylamine Drug2 : DB01615 Aceprometazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) --------------------------------------------------- Drug1 : DB00366 Doxylamine Drug2 : DB01619 Phenindamine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) --------------------------------------------------- Drug1 : DB00366 Doxylamine Drug2 : DB01620 Pheniramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) --------------------------------------------------- Drug1 : DB00366 Doxylamine Drug2 : DB04837 Clofedanol Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) --------------------------------------------------- Drug1 : DB00366 Doxylamine Drug2 : DB04890 Bepotastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) --------------------------------------------------- Drug1 : DB00366 Doxylamine Drug2 : DB06691 Mepyramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) --------------------------------------------------- Drug1 : DB00366 Doxylamine Drug2 : DB08799 Antazoline Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) --------------------------------------------------- Drug1 : DB00366 Doxylamine Drug2 : DB08800 Chloropyramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) --------------------------------------------------- Drug1 : DB00366 Doxylamine Drug2 : DB08801 Dimetindene Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) Non-common off-target(s) (drug2) : BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00366 Doxylamine Drug2 : DB08802 Isothipendyl Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) --------------------------------------------------- Drug1 : DB00366 Doxylamine Drug2 : DB08936 Chlorcyclizine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) --------------------------------------------------- Drug1 : DB00367 Levonorgestrel Drug2 : DB01126 Dutasteride Pharmacological target (-,-) : BE0000539 3-oxo-5-alpha-steroid 4-dehydrogenase 1 Non-common off-target(s) (drug1) : BE0000132 Androgen receptor (1) Non-common off-target(s) (drug2) : BE0000585 3-oxo-5-alpha-steroid 4-dehydrogenase 2 (-1) --------------------------------------------------- Drug1 : DB00371 Meprobamate Drug2 : DB00418 Secobarbital Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0004956 NMDA receptor (-1) --------------------------------------------------- Drug1 : DB00371 Meprobamate Drug2 : DB00463 Metharbital Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) --------------------------------------------------- Drug1 : DB00371 Meprobamate Drug2 : DB00599 Thiopental Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0002194 Fatty-acid amide hydrolase 1 (-1) --------------------------------------------------- Drug1 : DB00371 Meprobamate Drug2 : DB00794 Primidone Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) --------------------------------------------------- Drug1 : DB00371 Meprobamate Drug2 : DB00849 Methylphenobarbital Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) --------------------------------------------------- Drug1 : DB00371 Meprobamate Drug2 : DB01198 Zopiclone Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0000736 Translocator protein (1) --------------------------------------------------- Drug1 : DB00371 Meprobamate Drug2 : DB01351 Amobarbital Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) --------------------------------------------------- Drug1 : DB00371 Meprobamate Drug2 : DB01352 Aprobarbital Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) --------------------------------------------------- Drug1 : DB00371 Meprobamate Drug2 : DB01353 Butethal Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) --------------------------------------------------- Drug1 : DB00371 Meprobamate Drug2 : DB01354 Heptabarbital Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) --------------------------------------------------- Drug1 : DB00371 Meprobamate Drug2 : DB01355 Hexobarbital Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) --------------------------------------------------- Drug1 : DB00371 Meprobamate Drug2 : DB01483 Barbital Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) --------------------------------------------------- Drug1 : DB00371 Meprobamate Drug2 : DB01496 Barbituric acid derivative Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) --------------------------------------------------- Drug1 : DB00371 Meprobamate Drug2 : DB01544 Flunitrazepam Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) Non-common off-target(s) (drug2) : BE0000736 Translocator protein (1) --------------------------------------------------- Drug1 : DB00373 Timolol Drug2 : DB00489 Sotalol Pharmacological target (-,-) : BE0000172 Beta-1 adrenergic receptor Pharmacological target (-,-) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug2) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) --------------------------------------------------- Drug1 : DB00373 Timolol Drug2 : DB00598 Labetalol Pharmacological target (-,-) : BE0000172 Beta-1 adrenergic receptor Pharmacological target (-,-) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug2) : BE0004863 Alpha-1 adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00373 Timolol Drug2 : DB00866 Alprenolol Pharmacological target (-,-) : BE0000172 Beta-1 adrenergic receptor Pharmacological target (-,-) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug2) : BE0000291 5-hydroxytryptamine receptor 1A (-1) --------------------------------------------------- Drug1 : DB00373 Timolol Drug2 : DB01210 Levobunolol Pharmacological target (-,-) : BE0000172 Beta-1 adrenergic receptor Pharmacological target (-,-) : BE0000694 Beta-2 adrenergic receptor --------------------------------------------------- Drug1 : DB00373 Timolol Drug2 : DB01214 Metipranolol Pharmacological target (-,-) : BE0000172 Beta-1 adrenergic receptor Pharmacological target (-,-) : BE0000694 Beta-2 adrenergic receptor --------------------------------------------------- Drug1 : DB00373 Timolol Drug2 : DB01297 Practolol Pharmacological target (-,-) : BE0000172 Beta-1 adrenergic receptor Non-common off-target(s) (drug1) : BE0000694 Beta-2 adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00374 Treprostinil Drug2 : DB01240 Epoprostenol Pharmacological target (+,+) : BE0000110 P2Y purinoceptor 12 Pharmacological target (+,+) : BE0000475 Prostacyclin receptor Non-common off-target(s) (drug1) : BE0001007 Peroxisome proliferator-activated receptor delta (1) Non-common off-target(s) (drug2) : BE0000117 Prostacyclin synthase (1) --------------------------------------------------- Drug1 : DB00376 Trihexyphenidyl Drug2 : DB00670 Pirenzepine Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00376 Trihexyphenidyl Drug2 : DB00771 Clidinium Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00376 Trihexyphenidyl Drug2 : DB00782 Propantheline Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00376 Trihexyphenidyl Drug2 : DB00810 Biperiden Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) Non-common off-target(s) (drug2) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) --------------------------------------------------- Drug1 : DB00376 Trihexyphenidyl Drug2 : DB00942 Cycrimine Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00376 Trihexyphenidyl Drug2 : DB00979 Cyclopentolate Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00377 Palonosetron Drug2 : DB00757 Dolasetron Pharmacological target (-,-) : BE0000311 5-hydroxytryptamine receptor 3A --------------------------------------------------- Drug1 : DB00377 Palonosetron Drug2 : DB00889 Granisetron Pharmacological target (-,-) : BE0000311 5-hydroxytryptamine receptor 3A --------------------------------------------------- Drug1 : DB00377 Palonosetron Drug2 : DB00904 Ondansetron Pharmacological target (-,-) : BE0000311 5-hydroxytryptamine receptor 3A Non-common off-target(s) (drug2) : BE0000084 5-hydroxytryptamine receptor 4 (1) --------------------------------------------------- Drug1 : DB00377 Palonosetron Drug2 : DB00969 Alosetron Pharmacological target (-,-) : BE0000311 5-hydroxytryptamine receptor 3A --------------------------------------------------- Drug1 : DB00377 Palonosetron Drug2 : DB01199 Tubocurarine Pharmacological target (-,-) : BE0000311 5-hydroxytryptamine receptor 3A Non-common off-target(s) (drug2) : BE0000426 Acetylcholinesterase (-1) BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) --------------------------------------------------- Drug1 : DB00378 Dydrogesterone Drug2 : DB00603 Medroxyprogesterone Acetate Pharmacological target (+,+) : BE0000557 Progesterone receptor Non-common off-target(s) (drug2) : BE0000123 Estrogen receptor (1) --------------------------------------------------- Drug1 : DB00378 Dydrogesterone Drug2 : DB00823 Ethynodiol Pharmacological target (+,+) : BE0000557 Progesterone receptor Non-common off-target(s) (drug2) : BE0000123 Estrogen receptor (1) --------------------------------------------------- Drug1 : DB00378 Dydrogesterone Drug2 : DB00957 Norgestimate Pharmacological target (+,+) : BE0000557 Progesterone receptor Non-common off-target(s) (drug2) : BE0000123 Estrogen receptor (1) --------------------------------------------------- Drug1 : DB00378 Dydrogesterone Drug2 : DB01431 Allylestrenol Pharmacological target (+,+) : BE0000557 Progesterone receptor Non-common off-target(s) (drug2) : BE0000123 Estrogen receptor (1) --------------------------------------------------- Drug1 : DB00378 Dydrogesterone Drug2 : DB06713 Norelgestromin Pharmacological target (+,+) : BE0000557 Progesterone receptor --------------------------------------------------- Drug1 : DB00379 Mexiletine Drug2 : DB00473 Hexylcaine Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0003721 Aryl hydrocarbon receptor (1) Non-common off-target(s) (drug2) : BE0000177 Sodium channel protein type 10 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00379 Mexiletine Drug2 : DB00527 Cinchocaine Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0003721 Aryl hydrocarbon receptor (1) Non-common off-target(s) (drug2) : BE0000177 Sodium channel protein type 10 subunit alpha (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00379 Mexiletine Drug2 : DB00532 Mephenytoin Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0003721 Aryl hydrocarbon receptor (1) --------------------------------------------------- Drug1 : DB00379 Mexiletine Drug2 : DB00564 Carbamazepine Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0003721 Aryl hydrocarbon receptor (1) --------------------------------------------------- Drug1 : DB00379 Mexiletine Drug2 : DB00680 Moricizine Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0003721 Aryl hydrocarbon receptor (1) --------------------------------------------------- Drug1 : DB00379 Mexiletine Drug2 : DB00740 Riluzole Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0003721 Aryl hydrocarbon receptor (1) Non-common off-target(s) (drug2) : BE0000030 Cystine/glutamate transporter (1) --------------------------------------------------- Drug1 : DB00379 Mexiletine Drug2 : DB00750 Prilocaine Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0003721 Aryl hydrocarbon receptor (1) --------------------------------------------------- Drug1 : DB00379 Mexiletine Drug2 : DB00754 Ethotoin Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0003721 Aryl hydrocarbon receptor (1) --------------------------------------------------- Drug1 : DB00379 Mexiletine Drug2 : DB00776 Oxcarbazepine Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0003721 Aryl hydrocarbon receptor (1) --------------------------------------------------- Drug1 : DB00379 Mexiletine Drug2 : DB00908 Quinidine Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0003721 Aryl hydrocarbon receptor (1) Non-common off-target(s) (drug2) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000154 Potassium channel subfamily K member 1 (-1) BE0000680 Potassium channel subfamily K member 6 (-1) --------------------------------------------------- Drug1 : DB00379 Mexiletine Drug2 : DB01056 Tocainide Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0003721 Aryl hydrocarbon receptor (1) --------------------------------------------------- Drug1 : DB00379 Mexiletine Drug2 : DB01182 Propafenone Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0003721 Aryl hydrocarbon receptor (1) Non-common off-target(s) (drug2) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) --------------------------------------------------- Drug1 : DB00379 Mexiletine Drug2 : DB01195 Flecainide Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0003721 Aryl hydrocarbon receptor (1) Non-common off-target(s) (drug2) : BE0002083 Sodium channel protein type 4 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00379 Mexiletine Drug2 : DB01228 Encainide Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0003721 Aryl hydrocarbon receptor (1) --------------------------------------------------- Drug1 : DB00379 Mexiletine Drug2 : DB01320 Fosphenytoin Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0003721 Aryl hydrocarbon receptor (1) --------------------------------------------------- Drug1 : DB00379 Mexiletine Drug2 : DB01426 Ajmaline Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0003721 Aryl hydrocarbon receptor (1) --------------------------------------------------- Drug1 : DB00379 Mexiletine Drug2 : DB01429 Aprindine Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0003721 Aryl hydrocarbon receptor (1) Non-common off-target(s) (drug2) : BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00380 Dexrazoxane Drug2 : DB00385 Valrubicin Pharmacological target (-,-) : BE0000742 DNA topoisomerase 2-alpha --------------------------------------------------- Drug1 : DB00380 Dexrazoxane Drug2 : DB00444 Teniposide Pharmacological target (-,-) : BE0000742 DNA topoisomerase 2-alpha --------------------------------------------------- Drug1 : DB00380 Dexrazoxane Drug2 : DB00694 Daunorubicin Pharmacological target (-,-) : BE0000742 DNA topoisomerase 2-alpha Non-common off-target(s) (drug2) : BE0002425 DNA topoisomerase 2-beta (-1) --------------------------------------------------- Drug1 : DB00380 Dexrazoxane Drug2 : DB00773 Etoposide Pharmacological target (-,-) : BE0000742 DNA topoisomerase 2-alpha Non-common off-target(s) (drug2) : BE0002425 DNA topoisomerase 2-beta (-1) --------------------------------------------------- Drug1 : DB00380 Dexrazoxane Drug2 : DB00997 Doxorubicin Pharmacological target (-,-) : BE0000742 DNA topoisomerase 2-alpha --------------------------------------------------- Drug1 : DB00380 Dexrazoxane Drug2 : DB01137 Levofloxacin Pharmacological target (-,-) : BE0000742 DNA topoisomerase 2-alpha --------------------------------------------------- Drug1 : DB00380 Dexrazoxane Drug2 : DB01177 Idarubicin Pharmacological target (-,-) : BE0000742 DNA topoisomerase 2-alpha --------------------------------------------------- Drug1 : DB00380 Dexrazoxane Drug2 : DB01204 Mitoxantrone Pharmacological target (-,-) : BE0000742 DNA topoisomerase 2-alpha --------------------------------------------------- Drug1 : DB00380 Dexrazoxane Drug2 : DB01208 Sparfloxacin Pharmacological target (-,-) : BE0000742 DNA topoisomerase 2-alpha --------------------------------------------------- Drug1 : DB00380 Dexrazoxane Drug2 : DB04576 Fleroxacin Pharmacological target (-,-) : BE0000742 DNA topoisomerase 2-alpha --------------------------------------------------- Drug1 : DB00380 Dexrazoxane Drug2 : DB09047 Finafloxacin Pharmacological target (-,-) : BE0000742 DNA topoisomerase 2-alpha --------------------------------------------------- Drug1 : DB00381 Amlodipine Drug2 : DB00393 Nimodipine Pharmacological target (-,-) : BE0000430 Voltage-dependent L-type calcium channel subunit alpha-1C Pharmacological target (-,-) : BE0002354 Voltage-dependent L-type calcium channel subunit beta-2 Pharmacological target (-,-) : BE0002359 Voltage-dependent L-type calcium channel subunit alpha-1D Pharmacological target (-,-) : BE0002355 Voltage-dependent L-type calcium channel subunit alpha-1S Non-common off-target(s) (drug1) : BE0000267 Carbonic anhydrase 1 (-1) BE0000691 Voltage-dependent calcium channel subunit alpha-2/delta-1 (-1) BE0002226 Voltage-dependent N-type calcium channel subunit alpha-1B (-1) BE0003563 Voltage-dependent calcium channel subunit alpha-2/delta-3 (-1) BE0003564 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d (-1) Non-common off-target(s) (drug2) : BE0000303 Voltage-dependent L-type calcium channel subunit beta-1 (-1) BE0003721 Aryl hydrocarbon receptor (1) BE0002357 Voltage-dependent L-type calcium channel subunit alpha-1F (-1) BE0002358 Voltage-dependent L-type calcium channel subunit beta-3 (-1) BE0002356 Voltage-dependent L-type calcium channel subunit beta-4 (-1) BE0000668 Mineralocorticoid receptor (-1) --------------------------------------------------- Drug1 : DB00381 Amlodipine Drug2 : DB00401 Nisoldipine Pharmacological target (-,-) : BE0000430 Voltage-dependent L-type calcium channel subunit alpha-1C Pharmacological target (-,-) : BE0000691 Voltage-dependent calcium channel subunit alpha-2/delta-1 Pharmacological target (-,-) : BE0002354 Voltage-dependent L-type calcium channel subunit beta-2 Pharmacological target (-,-) : BE0002359 Voltage-dependent L-type calcium channel subunit alpha-1D Pharmacological target (-,-) : BE0002355 Voltage-dependent L-type calcium channel subunit alpha-1S Non-common off-target(s) (drug1) : BE0000267 Carbonic anhydrase 1 (-1) BE0002226 Voltage-dependent N-type calcium channel subunit alpha-1B (-1) BE0003563 Voltage-dependent calcium channel subunit alpha-2/delta-3 (-1) BE0003564 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d (-1) --------------------------------------------------- Drug1 : DB00381 Amlodipine Drug2 : DB00622 Nicardipine Pharmacological target (-,-) : BE0000430 Voltage-dependent L-type calcium channel subunit alpha-1C Pharmacological target (-,-) : BE0000691 Voltage-dependent calcium channel subunit alpha-2/delta-1 Pharmacological target (-,-) : BE0002354 Voltage-dependent L-type calcium channel subunit beta-2 Pharmacological target (-,-) : BE0002359 Voltage-dependent L-type calcium channel subunit alpha-1D Non-common off-target(s) (drug1) : BE0000267 Carbonic anhydrase 1 (-1) BE0002355 Voltage-dependent L-type calcium channel subunit alpha-1S (-1) BE0002226 Voltage-dependent N-type calcium channel subunit alpha-1B (-1) BE0003563 Voltage-dependent calcium channel subunit alpha-2/delta-3 (-1) BE0003564 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0003565 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (-1) BE0003323 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (-1) --------------------------------------------------- Drug1 : DB00381 Amlodipine Drug2 : DB01023 Felodipine Pharmacological target (-,-) : BE0000430 Voltage-dependent L-type calcium channel subunit alpha-1C Pharmacological target (-,-) : BE0000691 Voltage-dependent calcium channel subunit alpha-2/delta-1 Pharmacological target (-,-) : BE0002354 Voltage-dependent L-type calcium channel subunit beta-2 Pharmacological target (-,-) : BE0002359 Voltage-dependent L-type calcium channel subunit alpha-1D Pharmacological target (-,-) : BE0002355 Voltage-dependent L-type calcium channel subunit alpha-1S Non-common off-target(s) (drug1) : BE0000267 Carbonic anhydrase 1 (-1) BE0002226 Voltage-dependent N-type calcium channel subunit alpha-1B (-1) BE0003563 Voltage-dependent calcium channel subunit alpha-2/delta-3 (-1) BE0003564 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d (-1) Non-common off-target(s) (drug2) : BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0002396 Voltage-dependent calcium channel subunit alpha-2/delta-2 (-1) BE0000668 Mineralocorticoid receptor (-1) BE0003565 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (-1) BE0003323 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (-1) --------------------------------------------------- Drug1 : DB00381 Amlodipine Drug2 : DB01054 Nitrendipine Pharmacological target (-,-) : BE0000430 Voltage-dependent L-type calcium channel subunit alpha-1C Pharmacological target (-,-) : BE0000691 Voltage-dependent calcium channel subunit alpha-2/delta-1 Pharmacological target (-,-) : BE0002354 Voltage-dependent L-type calcium channel subunit beta-2 Pharmacological target (-,-) : BE0002359 Voltage-dependent L-type calcium channel subunit alpha-1D Pharmacological target (-,-) : BE0002355 Voltage-dependent L-type calcium channel subunit alpha-1S Non-common off-target(s) (drug1) : BE0000267 Carbonic anhydrase 1 (-1) BE0002226 Voltage-dependent N-type calcium channel subunit alpha-1B (-1) BE0003563 Voltage-dependent calcium channel subunit alpha-2/delta-3 (-1) BE0003564 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d (-1) Non-common off-target(s) (drug2) : BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0002396 Voltage-dependent calcium channel subunit alpha-2/delta-2 (-1) BE0000679 Voltage-dependent calcium channel gamma-1 subunit (-1) --------------------------------------------------- Drug1 : DB00381 Amlodipine Drug2 : DB01115 Nifedipine Pharmacological target (-,-) : BE0000430 Voltage-dependent L-type calcium channel subunit alpha-1C Pharmacological target (-,-) : BE0000691 Voltage-dependent calcium channel subunit alpha-2/delta-1 Pharmacological target (-,-) : BE0002354 Voltage-dependent L-type calcium channel subunit beta-2 Pharmacological target (-,-) : BE0002359 Voltage-dependent L-type calcium channel subunit alpha-1D Pharmacological target (-,-) : BE0002355 Voltage-dependent L-type calcium channel subunit alpha-1S Non-common off-target(s) (drug1) : BE0000267 Carbonic anhydrase 1 (-1) BE0002226 Voltage-dependent N-type calcium channel subunit alpha-1B (-1) BE0003563 Voltage-dependent calcium channel subunit alpha-2/delta-3 (-1) BE0003564 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d (-1) Non-common off-target(s) (drug2) : BE0000781 Potassium voltage-gated channel subfamily A member 1 (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00382 Tacrine Drug2 : DB00483 Gallamine Triethiodide Pharmacological target (-,-) : BE0000426 Acetylcholinesterase Non-common off-target(s) (drug1) : BE0002180 Cholinesterase (-1) Non-common off-target(s) (drug2) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00382 Tacrine Drug2 : DB00545 Pyridostigmine Pharmacological target (-,-) : BE0000426 Acetylcholinesterase Pharmacological target (-,-) : BE0002180 Cholinesterase --------------------------------------------------- Drug1 : DB00382 Tacrine Drug2 : DB00677 Isoflurophate Pharmacological target (-,-) : BE0000426 Acetylcholinesterase Pharmacological target (-,-) : BE0002180 Cholinesterase --------------------------------------------------- Drug1 : DB00382 Tacrine Drug2 : DB00772 Malathion Pharmacological target (-,-) : BE0002180 Cholinesterase Non-common off-target(s) (drug1) : BE0000426 Acetylcholinesterase (-1) --------------------------------------------------- Drug1 : DB00382 Tacrine Drug2 : DB00843 Donepezil Pharmacological target (-,-) : BE0000426 Acetylcholinesterase Non-common off-target(s) (drug1) : BE0002180 Cholinesterase (-1) --------------------------------------------------- Drug1 : DB00382 Tacrine Drug2 : DB00941 Hexafluronium Pharmacological target (-,-) : BE0002180 Cholinesterase Non-common off-target(s) (drug1) : BE0000426 Acetylcholinesterase (-1) --------------------------------------------------- Drug1 : DB00382 Tacrine Drug2 : DB00981 Physostigmine Pharmacological target (-,-) : BE0000426 Acetylcholinesterase Non-common off-target(s) (drug1) : BE0002180 Cholinesterase (-1) --------------------------------------------------- Drug1 : DB00382 Tacrine Drug2 : DB00989 Rivastigmine Pharmacological target (-,-) : BE0000426 Acetylcholinesterase Pharmacological target (-,-) : BE0002180 Cholinesterase --------------------------------------------------- Drug1 : DB00382 Tacrine Drug2 : DB01010 Edrophonium Pharmacological target (-,-) : BE0000426 Acetylcholinesterase Pharmacological target (-,-) : BE0002180 Cholinesterase --------------------------------------------------- Drug1 : DB00382 Tacrine Drug2 : DB01057 Echothiophate Pharmacological target (-,-) : BE0002180 Cholinesterase Non-common off-target(s) (drug1) : BE0000426 Acetylcholinesterase (-1) --------------------------------------------------- Drug1 : DB00382 Tacrine Drug2 : DB01122 Ambenonium Pharmacological target (-,-) : BE0000426 Acetylcholinesterase Non-common off-target(s) (drug1) : BE0002180 Cholinesterase (-1) --------------------------------------------------- Drug1 : DB00382 Tacrine Drug2 : DB01400 Neostigmine Pharmacological target (-,-) : BE0000426 Acetylcholinesterase Non-common off-target(s) (drug1) : BE0002180 Cholinesterase (-1) --------------------------------------------------- Drug1 : DB00382 Tacrine Drug2 : DB08996 Dimetacrine Pharmacological target (-,-) : BE0000426 Acetylcholinesterase Non-common off-target(s) (drug1) : BE0002180 Cholinesterase (-1) --------------------------------------------------- Drug1 : DB00383 Oxyphencyclimine Drug2 : DB00387 Procyclidine Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug2) : BE0000405 Muscarinic acetylcholine receptor M4 (-1) --------------------------------------------------- Drug1 : DB00383 Oxyphencyclimine Drug2 : DB00505 Tridihexethyl Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 --------------------------------------------------- Drug1 : DB00383 Oxyphencyclimine Drug2 : DB00517 Anisotropine Methylbromide Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 --------------------------------------------------- Drug1 : DB00383 Oxyphencyclimine Drug2 : DB00572 Atropine Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug2) : BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00383 Oxyphencyclimine Drug2 : DB00725 Homatropine Methylbromide Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug2) : BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00383 Oxyphencyclimine Drug2 : DB00767 Benzquinamide Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug2) : BE0000442 Histamine H1 receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00383 Oxyphencyclimine Drug2 : DB00785 Cryptenamine Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug2) : BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00383 Oxyphencyclimine Drug2 : DB01036 Tolterodine Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug2) : BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00383 Oxyphencyclimine Drug2 : DB01062 Oxybutynin Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 --------------------------------------------------- Drug1 : DB00383 Oxyphencyclimine Drug2 : DB01148 Flavoxate Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) --------------------------------------------------- Drug1 : DB00383 Oxyphencyclimine Drug2 : DB01231 Diphenidol Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 --------------------------------------------------- Drug1 : DB00383 Oxyphencyclimine Drug2 : DB04843 Mepenzolate Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00383 Oxyphencyclimine Drug2 : DB08897 Aclidinium Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug2) : BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00385 Valrubicin Drug2 : DB00444 Teniposide Pharmacological target (-,-) : BE0000742 DNA topoisomerase 2-alpha --------------------------------------------------- Drug1 : DB00385 Valrubicin Drug2 : DB00694 Daunorubicin Pharmacological target (-,-) : BE0000742 DNA topoisomerase 2-alpha Non-common off-target(s) (drug2) : BE0002425 DNA topoisomerase 2-beta (-1) --------------------------------------------------- Drug1 : DB00385 Valrubicin Drug2 : DB00773 Etoposide Pharmacological target (-,-) : BE0000742 DNA topoisomerase 2-alpha Non-common off-target(s) (drug2) : BE0002425 DNA topoisomerase 2-beta (-1) --------------------------------------------------- Drug1 : DB00385 Valrubicin Drug2 : DB00997 Doxorubicin Pharmacological target (-,-) : BE0000742 DNA topoisomerase 2-alpha --------------------------------------------------- Drug1 : DB00385 Valrubicin Drug2 : DB01137 Levofloxacin Pharmacological target (-,-) : BE0000742 DNA topoisomerase 2-alpha --------------------------------------------------- Drug1 : DB00385 Valrubicin Drug2 : DB01177 Idarubicin Pharmacological target (-,-) : BE0000742 DNA topoisomerase 2-alpha --------------------------------------------------- Drug1 : DB00385 Valrubicin Drug2 : DB01204 Mitoxantrone Pharmacological target (-,-) : BE0000742 DNA topoisomerase 2-alpha --------------------------------------------------- Drug1 : DB00385 Valrubicin Drug2 : DB01208 Sparfloxacin Pharmacological target (-,-) : BE0000742 DNA topoisomerase 2-alpha --------------------------------------------------- Drug1 : DB00385 Valrubicin Drug2 : DB04576 Fleroxacin Pharmacological target (-,-) : BE0000742 DNA topoisomerase 2-alpha --------------------------------------------------- Drug1 : DB00385 Valrubicin Drug2 : DB09047 Finafloxacin Pharmacological target (-,-) : BE0000742 DNA topoisomerase 2-alpha --------------------------------------------------- Drug1 : DB00386 Alseroxylon Drug2 : DB01089 Deserpidine Pharmacological target (-,-) : BE0000118 Synaptic vesicular amine transporter --------------------------------------------------- Drug1 : DB00386 Alseroxylon Drug2 : DB04844 Tetrabenazine Pharmacological target (-,-) : BE0000118 Synaptic vesicular amine transporter Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00386 Alseroxylon Drug2 : DB06706 Isometheptene Pharmacological target (-,-) : BE0000118 Synaptic vesicular amine transporter Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00387 Procyclidine Drug2 : DB00505 Tridihexethyl Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000405 Muscarinic acetylcholine receptor M4 (-1) --------------------------------------------------- Drug1 : DB00387 Procyclidine Drug2 : DB00517 Anisotropine Methylbromide Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000405 Muscarinic acetylcholine receptor M4 (-1) --------------------------------------------------- Drug1 : DB00387 Procyclidine Drug2 : DB00572 Atropine Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Pharmacological target (-,-) : BE0000405 Muscarinic acetylcholine receptor M4 Non-common off-target(s) (drug2) : BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00387 Procyclidine Drug2 : DB00725 Homatropine Methylbromide Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Pharmacological target (-,-) : BE0000405 Muscarinic acetylcholine receptor M4 Non-common off-target(s) (drug2) : BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00387 Procyclidine Drug2 : DB00767 Benzquinamide Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Pharmacological target (-,-) : BE0000405 Muscarinic acetylcholine receptor M4 Non-common off-target(s) (drug2) : BE0000442 Histamine H1 receptor (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00387 Procyclidine Drug2 : DB00785 Cryptenamine Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Pharmacological target (-,-) : BE0000405 Muscarinic acetylcholine receptor M4 Non-common off-target(s) (drug2) : BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00387 Procyclidine Drug2 : DB01036 Tolterodine Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Pharmacological target (-,-) : BE0000405 Muscarinic acetylcholine receptor M4 Non-common off-target(s) (drug2) : BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00387 Procyclidine Drug2 : DB01062 Oxybutynin Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000405 Muscarinic acetylcholine receptor M4 (-1) --------------------------------------------------- Drug1 : DB00387 Procyclidine Drug2 : DB01148 Flavoxate Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) --------------------------------------------------- Drug1 : DB00387 Procyclidine Drug2 : DB01231 Diphenidol Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000405 Muscarinic acetylcholine receptor M4 (-1) --------------------------------------------------- Drug1 : DB00387 Procyclidine Drug2 : DB04843 Mepenzolate Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) --------------------------------------------------- Drug1 : DB00387 Procyclidine Drug2 : DB08897 Aclidinium Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Pharmacological target (-,-) : BE0000405 Muscarinic acetylcholine receptor M4 Non-common off-target(s) (drug2) : BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00389 Carbimazole Drug2 : DB00550 Propylthiouracil Pharmacological target (-,-) : BE0000507 Thyroid peroxidase --------------------------------------------------- Drug1 : DB00389 Carbimazole Drug2 : DB00763 Methimazole Pharmacological target (-,-) : BE0000507 Thyroid peroxidase --------------------------------------------------- Drug1 : DB00391 Sulpiride Drug2 : DB00408 Loxapine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000581 D(3) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00391 Sulpiride Drug2 : DB00420 Promazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000581 D(3) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00391 Sulpiride Drug2 : DB00433 Prochlorperazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000581 D(3) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00391 Sulpiride Drug2 : DB00450 Droperidol Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000581 D(3) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00391 Sulpiride Drug2 : DB00490 Buspirone Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000581 D(3) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000291 5-hydroxytryptamine receptor 1A (1) --------------------------------------------------- Drug1 : DB00391 Sulpiride Drug2 : DB00623 Fluphenazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000581 D(3) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000020 D(1A) dopamine receptor (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00391 Sulpiride Drug2 : DB00850 Perphenazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000581 D(3) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000020 D(1A) dopamine receptor (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00391 Sulpiride Drug2 : DB00933 Mesoridazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000581 D(3) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB00391 Sulpiride Drug2 : DB01063 Acetophenazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000581 D(3) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00391 Sulpiride Drug2 : DB01233 Metoclopramide Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000581 D(3) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000092 Muscarinic acetylcholine receptor M1 (1) BE0000311 5-hydroxytryptamine receptor 3A (1) BE0000084 5-hydroxytryptamine receptor 4 (1) --------------------------------------------------- Drug1 : DB00391 Sulpiride Drug2 : DB01425 Alizapride Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000581 D(3) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00391 Sulpiride Drug2 : DB01618 Molindone Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000581 D(3) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB00391 Sulpiride Drug2 : DB04842 Fluspirilene Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000581 D(3) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000679 Voltage-dependent calcium channel gamma-1 subunit (-1) --------------------------------------------------- Drug1 : DB00391 Sulpiride Drug2 : DB08815 Lurasidone Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000581 D(3) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000342 Alpha-2C adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00391 Sulpiride Drug2 : DB09018 Bromopride Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000581 D(3) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00392 Ethopropazine Drug2 : DB00670 Pirenzepine Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00392 Ethopropazine Drug2 : DB00771 Clidinium Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00392 Ethopropazine Drug2 : DB00782 Propantheline Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00392 Ethopropazine Drug2 : DB00810 Biperiden Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) Non-common off-target(s) (drug2) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) --------------------------------------------------- Drug1 : DB00392 Ethopropazine Drug2 : DB00915 Amantadine Pharmacological target (-,-) : BE0000641 Glutamate receptor ionotropic, NMDA 3A Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (1) --------------------------------------------------- Drug1 : DB00392 Ethopropazine Drug2 : DB00942 Cycrimine Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00392 Ethopropazine Drug2 : DB00979 Cyclopentolate Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00392 Ethopropazine Drug2 : DB00986 Glycopyrrolate Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) --------------------------------------------------- Drug1 : DB00392 Ethopropazine Drug2 : DB01221 Ketamine Pharmacological target (-,-) : BE0000641 Glutamate receptor ionotropic, NMDA 3A Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (1) BE0000632 Kappa-type opioid receptor (1) BE0000384 Substance-P receptor (-1) BE0004957 5-hydroxytryptamine receptor 2 (-1) BE0004958 5-hydroxytryptamine receptor 1 (-1) --------------------------------------------------- Drug1 : DB00392 Ethopropazine Drug2 : DB03575 Phencyclidine Pharmacological target (-,-) : BE0000641 Glutamate receptor ionotropic, NMDA 3A Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00392 Ethopropazine Drug2 : DB04843 Mepenzolate Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) --------------------------------------------------- Drug1 : DB00393 Nimodipine Drug2 : DB00401 Nisoldipine Pharmacological target (-,-) : BE0000430 Voltage-dependent L-type calcium channel subunit alpha-1C Pharmacological target (-,-) : BE0002354 Voltage-dependent L-type calcium channel subunit beta-2 Pharmacological target (-,-) : BE0002359 Voltage-dependent L-type calcium channel subunit alpha-1D Pharmacological target (-,-) : BE0002355 Voltage-dependent L-type calcium channel subunit alpha-1S Non-common off-target(s) (drug1) : BE0000303 Voltage-dependent L-type calcium channel subunit beta-1 (-1) BE0003721 Aryl hydrocarbon receptor (1) BE0002357 Voltage-dependent L-type calcium channel subunit alpha-1F (-1) BE0002358 Voltage-dependent L-type calcium channel subunit beta-3 (-1) BE0002356 Voltage-dependent L-type calcium channel subunit beta-4 (-1) BE0000668 Mineralocorticoid receptor (-1) Non-common off-target(s) (drug2) : BE0000691 Voltage-dependent calcium channel subunit alpha-2/delta-1 (-1) --------------------------------------------------- Drug1 : DB00393 Nimodipine Drug2 : DB00568 Cinnarizine Pharmacological target (-,-) : BE0000430 Voltage-dependent L-type calcium channel subunit alpha-1C Pharmacological target (-,-) : BE0002359 Voltage-dependent L-type calcium channel subunit alpha-1D Pharmacological target (-,-) : BE0002355 Voltage-dependent L-type calcium channel subunit alpha-1S Pharmacological target (-,-) : BE0002357 Voltage-dependent L-type calcium channel subunit alpha-1F Non-common off-target(s) (drug1) : BE0002354 Voltage-dependent L-type calcium channel subunit beta-2 (-1) BE0000303 Voltage-dependent L-type calcium channel subunit beta-1 (-1) BE0003721 Aryl hydrocarbon receptor (1) BE0002358 Voltage-dependent L-type calcium channel subunit beta-3 (-1) BE0002356 Voltage-dependent L-type calcium channel subunit beta-4 (-1) BE0000668 Mineralocorticoid receptor (-1) Non-common off-target(s) (drug2) : BE0000442 Histamine H1 receptor (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0000483 Voltage-dependent T-type calcium channel subunit alpha-1G (-1) BE0000012 Voltage-dependent T-type calcium channel subunit alpha-1I (-1) --------------------------------------------------- Drug1 : DB00393 Nimodipine Drug2 : DB00661 Verapamil Pharmacological target (-,-) : BE0000430 Voltage-dependent L-type calcium channel subunit alpha-1C Pharmacological target (-,-) : BE0002354 Voltage-dependent L-type calcium channel subunit beta-2 Pharmacological target (-,-) : BE0002359 Voltage-dependent L-type calcium channel subunit alpha-1D Pharmacological target (-,-) : BE0002355 Voltage-dependent L-type calcium channel subunit alpha-1S Pharmacological target (-,-) : BE0000303 Voltage-dependent L-type calcium channel subunit beta-1 Pharmacological target (-,-) : BE0002357 Voltage-dependent L-type calcium channel subunit alpha-1F Pharmacological target (-,-) : BE0002358 Voltage-dependent L-type calcium channel subunit beta-3 Pharmacological target (-,-) : BE0002356 Voltage-dependent L-type calcium channel subunit beta-4 Non-common off-target(s) (drug1) : BE0003721 Aryl hydrocarbon receptor (1) BE0000668 Mineralocorticoid receptor (-1) Non-common off-target(s) (drug2) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000708 ATP-sensitive inward rectifier potassium channel 11 (-1) BE0000356 Voltage-dependent P/Q-type calcium channel subunit alpha-1A (-1) BE0000483 Voltage-dependent T-type calcium channel subunit alpha-1G (-1) BE0002226 Voltage-dependent N-type calcium channel subunit alpha-1B (-1) BE0000012 Voltage-dependent T-type calcium channel subunit alpha-1I (-1) --------------------------------------------------- Drug1 : DB00393 Nimodipine Drug2 : DB01054 Nitrendipine Pharmacological target (-,-) : BE0000430 Voltage-dependent L-type calcium channel subunit alpha-1C Pharmacological target (-,-) : BE0002354 Voltage-dependent L-type calcium channel subunit beta-2 Pharmacological target (-,-) : BE0002359 Voltage-dependent L-type calcium channel subunit alpha-1D Pharmacological target (-,-) : BE0002355 Voltage-dependent L-type calcium channel subunit alpha-1S Non-common off-target(s) (drug1) : BE0000303 Voltage-dependent L-type calcium channel subunit beta-1 (-1) BE0003721 Aryl hydrocarbon receptor (1) BE0002357 Voltage-dependent L-type calcium channel subunit alpha-1F (-1) BE0002358 Voltage-dependent L-type calcium channel subunit beta-3 (-1) BE0002356 Voltage-dependent L-type calcium channel subunit beta-4 (-1) BE0000668 Mineralocorticoid receptor (-1) Non-common off-target(s) (drug2) : BE0000691 Voltage-dependent calcium channel subunit alpha-2/delta-1 (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0002396 Voltage-dependent calcium channel subunit alpha-2/delta-2 (-1) BE0000679 Voltage-dependent calcium channel gamma-1 subunit (-1) --------------------------------------------------- Drug1 : DB00393 Nimodipine Drug2 : DB01115 Nifedipine Pharmacological target (-,-) : BE0000430 Voltage-dependent L-type calcium channel subunit alpha-1C Pharmacological target (-,-) : BE0002354 Voltage-dependent L-type calcium channel subunit beta-2 Pharmacological target (-,-) : BE0002359 Voltage-dependent L-type calcium channel subunit alpha-1D Pharmacological target (-,-) : BE0002355 Voltage-dependent L-type calcium channel subunit alpha-1S Non-common off-target(s) (drug1) : BE0000303 Voltage-dependent L-type calcium channel subunit beta-1 (-1) BE0003721 Aryl hydrocarbon receptor (1) BE0002357 Voltage-dependent L-type calcium channel subunit alpha-1F (-1) BE0002358 Voltage-dependent L-type calcium channel subunit beta-3 (-1) BE0002356 Voltage-dependent L-type calcium channel subunit beta-4 (-1) BE0000668 Mineralocorticoid receptor (-1) Non-common off-target(s) (drug2) : BE0000781 Potassium voltage-gated channel subfamily A member 1 (-1) BE0000691 Voltage-dependent calcium channel subunit alpha-2/delta-1 (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00393 Nimodipine Drug2 : DB01388 Mibefradil Pharmacological target (-,-) : BE0000430 Voltage-dependent L-type calcium channel subunit alpha-1C Pharmacological target (-,-) : BE0002354 Voltage-dependent L-type calcium channel subunit beta-2 Pharmacological target (-,-) : BE0002359 Voltage-dependent L-type calcium channel subunit alpha-1D Pharmacological target (-,-) : BE0002355 Voltage-dependent L-type calcium channel subunit alpha-1S Pharmacological target (-,-) : BE0000303 Voltage-dependent L-type calcium channel subunit beta-1 Pharmacological target (-,-) : BE0002357 Voltage-dependent L-type calcium channel subunit alpha-1F Pharmacological target (-,-) : BE0002358 Voltage-dependent L-type calcium channel subunit beta-3 Pharmacological target (-,-) : BE0002356 Voltage-dependent L-type calcium channel subunit beta-4 Non-common off-target(s) (drug1) : BE0003721 Aryl hydrocarbon receptor (1) BE0000668 Mineralocorticoid receptor (-1) Non-common off-target(s) (drug2) : BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0000483 Voltage-dependent T-type calcium channel subunit alpha-1G (-1) BE0000012 Voltage-dependent T-type calcium channel subunit alpha-1I (-1) --------------------------------------------------- Drug1 : DB00394 Beclomethasone Drug2 : DB00443 Betamethasone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00394 Beclomethasone Drug2 : DB00547 Desoximetasone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00394 Beclomethasone Drug2 : DB00588 Fluticasone Propionate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug2) : BE0000557 Progesterone receptor (1) BE0000668 Mineralocorticoid receptor (-1) BE0000657 Cytosolic phospholipase A2 (-1) --------------------------------------------------- Drug1 : DB00394 Beclomethasone Drug2 : DB00591 Fluocinolone Acetonide Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00394 Beclomethasone Drug2 : DB00596 Halobetasol Propionate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00394 Beclomethasone Drug2 : DB00620 Triamcinolone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00394 Beclomethasone Drug2 : DB00635 Prednisone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00394 Beclomethasone Drug2 : DB00663 Flumethasone Pivalate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00394 Beclomethasone Drug2 : DB00741 Hydrocortisone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug2) : BE0000422 Annexin A1 (1) --------------------------------------------------- Drug1 : DB00394 Beclomethasone Drug2 : DB00764 Mometasone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00394 Beclomethasone Drug2 : DB00769 Hydrocortamate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00394 Beclomethasone Drug2 : DB00838 Clocortolone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00394 Beclomethasone Drug2 : DB00846 Flurandrenolide Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00394 Beclomethasone Drug2 : DB00860 Prednisolone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00394 Beclomethasone Drug2 : DB00873 Loteprednol Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00394 Beclomethasone Drug2 : DB00896 Rimexolone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00394 Beclomethasone Drug2 : DB00959 Methylprednisolone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00394 Beclomethasone Drug2 : DB01013 Clobetasol propionate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00394 Beclomethasone Drug2 : DB01047 Fluocinonide Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug2) : BE0004659 Smoothened homolog (1) --------------------------------------------------- Drug1 : DB00394 Beclomethasone Drug2 : DB01130 Prednicarbate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00394 Beclomethasone Drug2 : DB01234 Dexamethasone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug2) : BE0000005 Nitric oxide synthase, inducible (-1) BE0000422 Annexin A1 (1) BE0000074 Nuclear receptor subfamily 0 group B member 1 (1) --------------------------------------------------- Drug1 : DB00394 Beclomethasone Drug2 : DB01260 Desonide Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00394 Beclomethasone Drug2 : DB01380 Cortisone acetate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00394 Beclomethasone Drug2 : DB01384 Paramethasone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00394 Beclomethasone Drug2 : DB01410 Ciclesonide Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00394 Beclomethasone Drug2 : DB06781 Difluprednate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00394 Beclomethasone Drug2 : DB08906 Fluticasone furoate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00396 Progesterone Drug2 : DB00603 Medroxyprogesterone Acetate Pharmacological target (+,+) : BE0000123 Estrogen receptor Pharmacological target (+,+) : BE0000557 Progesterone receptor Non-common off-target(s) (drug1) : BE0000344 Steroid 17-alpha-hydroxylase/17,20 lyase (-1) BE0000632 Kappa-type opioid receptor (1) BE0000668 Mineralocorticoid receptor (-1) --------------------------------------------------- Drug1 : DB00396 Progesterone Drug2 : DB00823 Ethynodiol Pharmacological target (+,+) : BE0000123 Estrogen receptor Pharmacological target (+,+) : BE0000557 Progesterone receptor Non-common off-target(s) (drug1) : BE0000344 Steroid 17-alpha-hydroxylase/17,20 lyase (-1) BE0000632 Kappa-type opioid receptor (1) BE0000668 Mineralocorticoid receptor (-1) --------------------------------------------------- Drug1 : DB00396 Progesterone Drug2 : DB00957 Norgestimate Pharmacological target (+,+) : BE0000123 Estrogen receptor Pharmacological target (+,+) : BE0000557 Progesterone receptor Non-common off-target(s) (drug1) : BE0000344 Steroid 17-alpha-hydroxylase/17,20 lyase (-1) BE0000632 Kappa-type opioid receptor (1) BE0000668 Mineralocorticoid receptor (-1) --------------------------------------------------- Drug1 : DB00396 Progesterone Drug2 : DB01395 Drospirenone Pharmacological target (+,+) : BE0000557 Progesterone receptor Pharmacological target (-,-) : BE0000668 Mineralocorticoid receptor Non-common off-target(s) (drug1) : BE0000344 Steroid 17-alpha-hydroxylase/17,20 lyase (-1) BE0000632 Kappa-type opioid receptor (1) BE0000123 Estrogen receptor (1) Non-common off-target(s) (drug2) : BE0000132 Androgen receptor (-1) --------------------------------------------------- Drug1 : DB00397 Phenylpropanolamine Drug2 : DB00610 Metaraminol Pharmacological target (+,+) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000020 D(1A) dopamine receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00397 Phenylpropanolamine Drug2 : DB00629 Guanabenz Pharmacological target (+,+) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000020 D(1A) dopamine receptor (1) --------------------------------------------------- Drug1 : DB00397 Phenylpropanolamine Drug2 : DB00633 Dexmedetomidine Pharmacological target (+,+) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000020 D(1A) dopamine receptor (1) --------------------------------------------------- Drug1 : DB00397 Phenylpropanolamine Drug2 : DB00723 Methoxamine Pharmacological target (+,+) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000020 D(1A) dopamine receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000575 Alpha-1B adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00397 Phenylpropanolamine Drug2 : DB00865 Benzphetamine Pharmacological target (+,+) : BE0000501 Alpha-1A adrenergic receptor Pharmacological target (+,+) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000020 D(1A) dopamine receptor (1) Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (1) BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB00397 Phenylpropanolamine Drug2 : DB00935 Oxymetazoline Pharmacological target (+,+) : BE0000501 Alpha-1A adrenergic receptor Pharmacological target (+,+) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000020 D(1A) dopamine receptor (1) Non-common off-target(s) (drug2) : BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00397 Phenylpropanolamine Drug2 : DB00964 Apraclonidine Pharmacological target (+,+) : BE0000501 Alpha-1A adrenergic receptor Pharmacological target (+,+) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000020 D(1A) dopamine receptor (1) Non-common off-target(s) (drug2) : BE0000572 Alpha-2B adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00397 Phenylpropanolamine Drug2 : DB01018 Guanfacine Pharmacological target (+,+) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000020 D(1A) dopamine receptor (1) --------------------------------------------------- Drug1 : DB00397 Phenylpropanolamine Drug2 : DB01253 Ergonovine Pharmacological target (+,+) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000020 D(1A) dopamine receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00397 Phenylpropanolamine Drug2 : DB01579 Phendimetrazine Pharmacological target (+,+) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000020 D(1A) dopamine receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000575 Alpha-1B adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00397 Phenylpropanolamine Drug2 : DB04948 Lofexidine Pharmacological target (+,+) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000020 D(1A) dopamine receptor (1) --------------------------------------------------- Drug1 : DB00397 Phenylpropanolamine Drug2 : DB06694 Xylometazoline Pharmacological target (+,+) : BE0000501 Alpha-1A adrenergic receptor Pharmacological target (+,+) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000020 D(1A) dopamine receptor (1) Non-common off-target(s) (drug2) : BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00397 Phenylpropanolamine Drug2 : DB06706 Isometheptene Pharmacological target (+,+) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000020 D(1A) dopamine receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (-1) --------------------------------------------------- Drug1 : DB00397 Phenylpropanolamine Drug2 : DB06707 Levonordefrin Pharmacological target (+,+) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000020 D(1A) dopamine receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB00397 Phenylpropanolamine Drug2 : DB06711 Naphazoline Pharmacological target (+,+) : BE0000501 Alpha-1A adrenergic receptor Pharmacological target (+,+) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000020 D(1A) dopamine receptor (1) --------------------------------------------------- Drug1 : DB00398 Sorafenib Drug2 : DB08896 Regorafenib Pharmacological target (-,-) : BE0002131 Fibroblast growth factor receptor 1 Pharmacological target (-,-) : BE0000205 Platelet-derived growth factor receptor beta Pharmacological target (-,-) : BE0000634 Serine/threonine-protein kinase B-raf Pharmacological target (-,-) : BE0000036 RAF proto-oncogene serine/threonine-protein kinase Pharmacological target (-,-) : BE0000023 Vascular endothelial growth factor receptor 3 Pharmacological target (-,-) : BE0000369 Vascular endothelial growth factor receptor 2 Pharmacological target (-,-) : BE0000453 Mast/stem cell growth factor receptor Kit Pharmacological target (-,-) : BE0002411 Proto-oncogene tyrosine-protein kinase receptor Ret Pharmacological target (-,-) : BE0000029 Vascular endothelial growth factor receptor 1 Non-common off-target(s) (drug1) : BE0000147 Receptor-type tyrosine-protein kinase FLT3 (-1) Non-common off-target(s) (drug2) : BE0000748 Fibroblast growth factor receptor 2 (-1) BE0000852 Platelet-derived growth factor receptor alpha (-1) BE0000014 Tyrosine-protein kinase ABL1 (-1) BE0001039 High affinity nerve growth factor receptor (-1) BE0003379 Angiopoietin-1 receptor (-1) BE0000841 Ephrin type-A receptor 2 (-1) BE0003390 Mitogen-activated protein kinase 11 (-1) BE0004741 Discoidin domain-containing receptor 2 (-1) BE0004742 Tyrosine-protein kinase FRK (-1) --------------------------------------------------- Drug1 : DB00398 Sorafenib Drug2 : DB09078 Lenvatinib Pharmacological target (-,-) : BE0002131 Fibroblast growth factor receptor 1 Pharmacological target (-,-) : BE0000023 Vascular endothelial growth factor receptor 3 Pharmacological target (-,-) : BE0000369 Vascular endothelial growth factor receptor 2 Pharmacological target (-,-) : BE0000453 Mast/stem cell growth factor receptor Kit Pharmacological target (-,-) : BE0000029 Vascular endothelial growth factor receptor 1 Non-common off-target(s) (drug1) : BE0000205 Platelet-derived growth factor receptor beta (-1) BE0000634 Serine/threonine-protein kinase B-raf (-1) BE0000036 RAF proto-oncogene serine/threonine-protein kinase (-1) BE0000147 Receptor-type tyrosine-protein kinase FLT3 (-1) BE0002411 Proto-oncogene tyrosine-protein kinase receptor Ret (-1) Non-common off-target(s) (drug2) : BE0000748 Fibroblast growth factor receptor 2 (-1) BE0001203 Fibroblast growth factor receptor 4 (-1) BE0002133 Fibroblast growth factor receptor 3 (-1) BE0008625 Platelet derived growth factor receptor alpha (-1) BE0008626 RET (-1) --------------------------------------------------- Drug1 : DB00399 Zoledronate Drug2 : DB00630 Alendronate Pharmacological target (-,-) : BE0000776 Farnesyl pyrophosphate synthase Pharmacological target (-,-) : BE0004801 Hydroxylapatite Non-common off-target(s) (drug1) : BE0003570 Geranylgeranyl pyrophosphate synthase (-1) Non-common off-target(s) (drug2) : BE0000980 Tyrosine-protein phosphatase non-receptor type 4 (-1) BE0003567 Receptor-type tyrosine-protein phosphatase S (-1) BE0003568 Receptor-type tyrosine-protein phosphatase epsilon (-1) BE0003569 V-type proton ATPase catalytic subunit A (-1) --------------------------------------------------- Drug1 : DB00399 Zoledronate Drug2 : DB00710 Ibandronate Pharmacological target (-,-) : BE0000776 Farnesyl pyrophosphate synthase Pharmacological target (-,-) : BE0004801 Hydroxylapatite Non-common off-target(s) (drug1) : BE0003570 Geranylgeranyl pyrophosphate synthase (-1) --------------------------------------------------- Drug1 : DB00399 Zoledronate Drug2 : DB00884 Risedronate Pharmacological target (-,-) : BE0000776 Farnesyl pyrophosphate synthase Pharmacological target (-,-) : BE0004801 Hydroxylapatite Non-common off-target(s) (drug1) : BE0003570 Geranylgeranyl pyrophosphate synthase (-1) --------------------------------------------------- Drug1 : DB00401 Nisoldipine Drug2 : DB00622 Nicardipine Pharmacological target (-,-) : BE0000430 Voltage-dependent L-type calcium channel subunit alpha-1C Pharmacological target (-,-) : BE0000691 Voltage-dependent calcium channel subunit alpha-2/delta-1 Pharmacological target (-,-) : BE0002354 Voltage-dependent L-type calcium channel subunit beta-2 Pharmacological target (-,-) : BE0002359 Voltage-dependent L-type calcium channel subunit alpha-1D Non-common off-target(s) (drug1) : BE0002355 Voltage-dependent L-type calcium channel subunit alpha-1S (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0003565 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (-1) BE0003323 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (-1) --------------------------------------------------- Drug1 : DB00401 Nisoldipine Drug2 : DB00661 Verapamil Pharmacological target (-,-) : BE0000430 Voltage-dependent L-type calcium channel subunit alpha-1C Pharmacological target (-,-) : BE0002354 Voltage-dependent L-type calcium channel subunit beta-2 Pharmacological target (-,-) : BE0002359 Voltage-dependent L-type calcium channel subunit alpha-1D Pharmacological target (-,-) : BE0002355 Voltage-dependent L-type calcium channel subunit alpha-1S Non-common off-target(s) (drug1) : BE0000691 Voltage-dependent calcium channel subunit alpha-2/delta-1 (-1) Non-common off-target(s) (drug2) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000708 ATP-sensitive inward rectifier potassium channel 11 (-1) BE0000356 Voltage-dependent P/Q-type calcium channel subunit alpha-1A (-1) BE0000303 Voltage-dependent L-type calcium channel subunit beta-1 (-1) BE0000483 Voltage-dependent T-type calcium channel subunit alpha-1G (-1) BE0002226 Voltage-dependent N-type calcium channel subunit alpha-1B (-1) BE0002357 Voltage-dependent L-type calcium channel subunit alpha-1F (-1) BE0002358 Voltage-dependent L-type calcium channel subunit beta-3 (-1) BE0002356 Voltage-dependent L-type calcium channel subunit beta-4 (-1) BE0000012 Voltage-dependent T-type calcium channel subunit alpha-1I (-1) --------------------------------------------------- Drug1 : DB00401 Nisoldipine Drug2 : DB01023 Felodipine Pharmacological target (-,-) : BE0000430 Voltage-dependent L-type calcium channel subunit alpha-1C Pharmacological target (-,-) : BE0000691 Voltage-dependent calcium channel subunit alpha-2/delta-1 Pharmacological target (-,-) : BE0002354 Voltage-dependent L-type calcium channel subunit beta-2 Pharmacological target (-,-) : BE0002359 Voltage-dependent L-type calcium channel subunit alpha-1D Pharmacological target (-,-) : BE0002355 Voltage-dependent L-type calcium channel subunit alpha-1S Non-common off-target(s) (drug2) : BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0002396 Voltage-dependent calcium channel subunit alpha-2/delta-2 (-1) BE0000668 Mineralocorticoid receptor (-1) BE0003565 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (-1) BE0003323 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (-1) --------------------------------------------------- Drug1 : DB00401 Nisoldipine Drug2 : DB01054 Nitrendipine Pharmacological target (-,-) : BE0000430 Voltage-dependent L-type calcium channel subunit alpha-1C Pharmacological target (-,-) : BE0000691 Voltage-dependent calcium channel subunit alpha-2/delta-1 Pharmacological target (-,-) : BE0002354 Voltage-dependent L-type calcium channel subunit beta-2 Pharmacological target (-,-) : BE0002359 Voltage-dependent L-type calcium channel subunit alpha-1D Pharmacological target (-,-) : BE0002355 Voltage-dependent L-type calcium channel subunit alpha-1S Non-common off-target(s) (drug2) : BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0002396 Voltage-dependent calcium channel subunit alpha-2/delta-2 (-1) BE0000679 Voltage-dependent calcium channel gamma-1 subunit (-1) --------------------------------------------------- Drug1 : DB00401 Nisoldipine Drug2 : DB01115 Nifedipine Pharmacological target (-,-) : BE0000430 Voltage-dependent L-type calcium channel subunit alpha-1C Pharmacological target (-,-) : BE0000691 Voltage-dependent calcium channel subunit alpha-2/delta-1 Pharmacological target (-,-) : BE0002354 Voltage-dependent L-type calcium channel subunit beta-2 Pharmacological target (-,-) : BE0002359 Voltage-dependent L-type calcium channel subunit alpha-1D Pharmacological target (-,-) : BE0002355 Voltage-dependent L-type calcium channel subunit alpha-1S Non-common off-target(s) (drug2) : BE0000781 Potassium voltage-gated channel subfamily A member 1 (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00402 Eszopiclone Drug2 : DB01107 Methyprylon Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000736 Translocator protein (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) --------------------------------------------------- Drug1 : DB00402 Eszopiclone Drug2 : DB01437 Glutethimide Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000736 Translocator protein (1) BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) --------------------------------------------------- Drug1 : DB00404 Alprazolam Drug2 : DB00475 Chlordiazepoxide Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) --------------------------------------------------- Drug1 : DB00404 Alprazolam Drug2 : DB00628 Clorazepate Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug2) : BE0000736 Translocator protein (1) --------------------------------------------------- Drug1 : DB00404 Alprazolam Drug2 : DB01068 Clonazepam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) --------------------------------------------------- Drug1 : DB00404 Alprazolam Drug2 : DB01107 Methyprylon Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug2) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) --------------------------------------------------- Drug1 : DB00404 Alprazolam Drug2 : DB01159 Halothane Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug2) : BE0000534 Glutamate receptor ionotropic, NMDA 3B (-1) BE0000760 Glutamate receptor ionotropic, NMDA 2A (-1) BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000503 NADH-ubiquinone oxidoreductase chain 1 (-1) BE0000415 Intermediate conductance calcium-activated potassium channel protein 4 (-1) BE0000553 Calcium-activated potassium channel subunit alpha-1 (-1) BE0001028 G protein-activated inward rectifier potassium channel 1 (-1) BE0001030 G protein-activated inward rectifier potassium channel 2 (-1) --------------------------------------------------- Drug1 : DB00404 Alprazolam Drug2 : DB01437 Glutethimide Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug2) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) --------------------------------------------------- Drug1 : DB00405 Dexbrompheniramine Drug2 : DB00427 Triprolidine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00405 Dexbrompheniramine Drug2 : DB00455 Loratadine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00405 Dexbrompheniramine Drug2 : DB00557 Hydroxyzine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00405 Dexbrompheniramine Drug2 : DB00637 Astemizole Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) --------------------------------------------------- Drug1 : DB00405 Dexbrompheniramine Drug2 : DB00719 Azatadine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00405 Dexbrompheniramine Drug2 : DB00737 Meclizine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00405 Dexbrompheniramine Drug2 : DB00748 Carbinoxamine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00405 Dexbrompheniramine Drug2 : DB00751 Epinastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000112 Histamine H2 receptor (-1) --------------------------------------------------- Drug1 : DB00405 Dexbrompheniramine Drug2 : DB00768 Olopatadine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0001090 Protein S100-A1 (-1) BE0001206 Protein S100-A12 (-1) BE0003602 Protein S100-A2 (-1) --------------------------------------------------- Drug1 : DB00405 Dexbrompheniramine Drug2 : DB00777 Propiomazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00405 Dexbrompheniramine Drug2 : DB00792 Tripelennamine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00405 Dexbrompheniramine Drug2 : DB00835 Brompheniramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00405 Dexbrompheniramine Drug2 : DB00902 Methdilazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00405 Dexbrompheniramine Drug2 : DB00950 Fexofenadine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00405 Dexbrompheniramine Drug2 : DB00967 Desloratadine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00405 Dexbrompheniramine Drug2 : DB00972 Azelastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00405 Dexbrompheniramine Drug2 : DB00985 Dimenhydrinate Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00405 Dexbrompheniramine Drug2 : DB01069 Promethazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00405 Dexbrompheniramine Drug2 : DB01071 Mequitazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00405 Dexbrompheniramine Drug2 : DB01075 Diphenhydramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00405 Dexbrompheniramine Drug2 : DB01084 Emedastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00405 Dexbrompheniramine Drug2 : DB01106 Levocabastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000464 Neurotensin receptor type 2 (-1) --------------------------------------------------- Drug1 : DB00405 Dexbrompheniramine Drug2 : DB01114 Chlorphenamine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB00405 Dexbrompheniramine Drug2 : DB01146 Diphenylpyraline Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB00405 Dexbrompheniramine Drug2 : DB01176 Cyclizine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000951 Estrogen sulfotransferase (-1) --------------------------------------------------- Drug1 : DB00405 Dexbrompheniramine Drug2 : DB01237 Bromodiphenhydramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00405 Dexbrompheniramine Drug2 : DB01246 Alimemazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00405 Dexbrompheniramine Drug2 : DB01615 Aceprometazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00405 Dexbrompheniramine Drug2 : DB01619 Phenindamine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00405 Dexbrompheniramine Drug2 : DB01620 Pheniramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00405 Dexbrompheniramine Drug2 : DB04837 Clofedanol Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00405 Dexbrompheniramine Drug2 : DB04890 Bepotastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00405 Dexbrompheniramine Drug2 : DB06691 Mepyramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00405 Dexbrompheniramine Drug2 : DB08799 Antazoline Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00405 Dexbrompheniramine Drug2 : DB08800 Chloropyramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00405 Dexbrompheniramine Drug2 : DB08801 Dimetindene Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00405 Dexbrompheniramine Drug2 : DB08802 Isothipendyl Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00405 Dexbrompheniramine Drug2 : DB08936 Chlorcyclizine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00407 Ardeparin Drug2 : DB00569 Fondaparinux sodium Pharmacological target (+,+) : BE0000280 Antithrombin-III Non-common off-target(s) (drug1) : BE0000775 Heparin cofactor 2 (1) Non-common off-target(s) (drug2) : BE0000216 Coagulation factor X (-1) --------------------------------------------------- Drug1 : DB00407 Ardeparin Drug2 : DB01109 Heparin Pharmacological target (+,+) : BE0000280 Antithrombin-III Non-common off-target(s) (drug1) : BE0000775 Heparin cofactor 2 (1) Non-common off-target(s) (drug2) : BE0000216 Coagulation factor X (-1) BE0001159 P-selectin (-1) --------------------------------------------------- Drug1 : DB00407 Ardeparin Drug2 : DB01225 Enoxaparin Pharmacological target (+,+) : BE0000280 Antithrombin-III Non-common off-target(s) (drug1) : BE0000775 Heparin cofactor 2 (1) Non-common off-target(s) (drug2) : BE0000216 Coagulation factor X (-1) --------------------------------------------------- Drug1 : DB00407 Ardeparin Drug2 : DB06271 Sulodexide Pharmacological target (+,+) : BE0000280 Antithrombin-III Pharmacological target (+,+) : BE0000775 Heparin cofactor 2 --------------------------------------------------- Drug1 : DB00407 Ardeparin Drug2 : DB06822 Tinzaparin Pharmacological target (+,+) : BE0000280 Antithrombin-III Non-common off-target(s) (drug1) : BE0000775 Heparin cofactor 2 (1) Non-common off-target(s) (drug2) : BE0000590 Integrin alpha-4 (-1) --------------------------------------------------- Drug1 : DB00407 Ardeparin Drug2 : DB08813 Nadroparin Pharmacological target (+,+) : BE0000280 Antithrombin-III Non-common off-target(s) (drug1) : BE0000775 Heparin cofactor 2 (1) Non-common off-target(s) (drug2) : BE0001159 P-selectin (-1) BE0001126 Proto-oncogene c-Fos (-1) BE0004689 Myc proto-oncogene protein (-1) --------------------------------------------------- Drug1 : DB00408 Loxapine Drug2 : DB00409 Remoxipride Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000581 D(3) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000156 Sigma non-opioid intracellular receptor 1 (-1) --------------------------------------------------- Drug1 : DB00408 Loxapine Drug2 : DB00433 Prochlorperazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00408 Loxapine Drug2 : DB00450 Droperidol Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00408 Loxapine Drug2 : DB00490 Buspirone Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000291 5-hydroxytryptamine receptor 1A (1) --------------------------------------------------- Drug1 : DB00408 Loxapine Drug2 : DB00924 Cyclobenzaprine Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00408 Loxapine Drug2 : DB00933 Mesoridazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00408 Loxapine Drug2 : DB01184 Domperidone Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000581 D(3) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00408 Loxapine Drug2 : DB01233 Metoclopramide Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000092 Muscarinic acetylcholine receptor M1 (1) BE0000311 5-hydroxytryptamine receptor 3A (1) BE0000084 5-hydroxytryptamine receptor 4 (1) --------------------------------------------------- Drug1 : DB00408 Loxapine Drug2 : DB01425 Alizapride Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00408 Loxapine Drug2 : DB08810 Cinitapride Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000020 D(1A) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000084 5-hydroxytryptamine receptor 4 (1) --------------------------------------------------- Drug1 : DB00408 Loxapine Drug2 : DB08815 Lurasidone Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000020 D(1A) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000342 Alpha-2C adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00408 Loxapine Drug2 : DB09018 Bromopride Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00409 Remoxipride Drug2 : DB00433 Prochlorperazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000581 D(3) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000156 Sigma non-opioid intracellular receptor 1 (-1) --------------------------------------------------- Drug1 : DB00409 Remoxipride Drug2 : DB00450 Droperidol Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000581 D(3) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000156 Sigma non-opioid intracellular receptor 1 (-1) Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00409 Remoxipride Drug2 : DB00490 Buspirone Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000581 D(3) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000156 Sigma non-opioid intracellular receptor 1 (-1) Non-common off-target(s) (drug2) : BE0000291 5-hydroxytryptamine receptor 1A (1) --------------------------------------------------- Drug1 : DB00409 Remoxipride Drug2 : DB00623 Fluphenazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000581 D(3) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000156 Sigma non-opioid intracellular receptor 1 (-1) Non-common off-target(s) (drug2) : BE0000020 D(1A) dopamine receptor (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00409 Remoxipride Drug2 : DB00850 Perphenazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000581 D(3) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000156 Sigma non-opioid intracellular receptor 1 (-1) Non-common off-target(s) (drug2) : BE0000020 D(1A) dopamine receptor (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00409 Remoxipride Drug2 : DB00933 Mesoridazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000581 D(3) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000156 Sigma non-opioid intracellular receptor 1 (-1) Non-common off-target(s) (drug2) : BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB00409 Remoxipride Drug2 : DB01063 Acetophenazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000581 D(3) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000156 Sigma non-opioid intracellular receptor 1 (-1) Non-common off-target(s) (drug2) : BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00409 Remoxipride Drug2 : DB01233 Metoclopramide Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000581 D(3) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000156 Sigma non-opioid intracellular receptor 1 (-1) Non-common off-target(s) (drug2) : BE0000092 Muscarinic acetylcholine receptor M1 (1) BE0000311 5-hydroxytryptamine receptor 3A (1) BE0000084 5-hydroxytryptamine receptor 4 (1) --------------------------------------------------- Drug1 : DB00409 Remoxipride Drug2 : DB01425 Alizapride Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000581 D(3) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000156 Sigma non-opioid intracellular receptor 1 (-1) --------------------------------------------------- Drug1 : DB00409 Remoxipride Drug2 : DB01618 Molindone Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000581 D(3) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000156 Sigma non-opioid intracellular receptor 1 (-1) Non-common off-target(s) (drug2) : BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB00409 Remoxipride Drug2 : DB04842 Fluspirilene Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000581 D(3) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000156 Sigma non-opioid intracellular receptor 1 (-1) Non-common off-target(s) (drug2) : BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000679 Voltage-dependent calcium channel gamma-1 subunit (-1) --------------------------------------------------- Drug1 : DB00409 Remoxipride Drug2 : DB08815 Lurasidone Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000581 D(3) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000156 Sigma non-opioid intracellular receptor 1 (-1) Non-common off-target(s) (drug2) : BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000342 Alpha-2C adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00409 Remoxipride Drug2 : DB09018 Bromopride Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000581 D(3) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000156 Sigma non-opioid intracellular receptor 1 (-1) --------------------------------------------------- Drug1 : DB00411 Carbachol Drug2 : DB01085 Pilocarpine Pharmacological target (+,+) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (+,+) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (1) --------------------------------------------------- Drug1 : DB00412 Rosiglitazone Drug2 : DB00966 Telmisartan Pharmacological target (+,+) : BE0000215 Peroxisome proliferator-activated receptor gamma Non-common off-target(s) (drug1) : BE0000996 Long-chain-fatty-acid--CoA ligase 4 (-1) Non-common off-target(s) (drug2) : BE0000062 Type-1 angiotensin II receptor (-1) --------------------------------------------------- Drug1 : DB00412 Rosiglitazone Drug2 : DB01132 Pioglitazone Pharmacological target (+,+) : BE0000215 Peroxisome proliferator-activated receptor gamma Non-common off-target(s) (drug1) : BE0000996 Long-chain-fatty-acid--CoA ligase 4 (-1) --------------------------------------------------- Drug1 : DB00412 Rosiglitazone Drug2 : DB08915 Aleglitazar Pharmacological target (+,+) : BE0000215 Peroxisome proliferator-activated receptor gamma Non-common off-target(s) (drug1) : BE0000996 Long-chain-fatty-acid--CoA ligase 4 (-1) Non-common off-target(s) (drug2) : BE0000071 Peroxisome proliferator-activated receptor alpha (1) --------------------------------------------------- Drug1 : DB00413 Pramipexole Drug2 : DB00589 Lisuride Pharmacological target (+,+) : BE0000756 D(2) dopamine receptor Pharmacological target (+,+) : BE0000581 D(3) dopamine receptor Pharmacological target (+,+) : BE0000389 D(4) dopamine receptor Non-common off-target(s) (drug1) : BE0000289 Alpha-2A adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000533 5-hydroxytryptamine receptor 2C (1) BE0000659 5-hydroxytryptamine receptor 1D (1) BE0000797 5-hydroxytryptamine receptor 1B (1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000451 5-hydroxytryptamine receptor 2A (1) BE0000020 D(1A) dopamine receptor (-1) BE0000145 D(1B) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00413 Pramipexole Drug2 : DB00988 Dopamine Pharmacological target (+,+) : BE0000756 D(2) dopamine receptor Pharmacological target (+,+) : BE0000581 D(3) dopamine receptor Pharmacological target (+,+) : BE0000389 D(4) dopamine receptor Non-common off-target(s) (drug1) : BE0000289 Alpha-2A adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (1) BE0000020 D(1A) dopamine receptor (1) BE0000145 D(1B) dopamine receptor (1) BE0004889 D(1) dopamine receptor (1) --------------------------------------------------- Drug1 : DB00413 Pramipexole Drug2 : DB01235 L-DOPA Pharmacological target (+,+) : BE0000756 D(2) dopamine receptor Pharmacological target (+,+) : BE0000581 D(3) dopamine receptor Pharmacological target (+,+) : BE0000389 D(4) dopamine receptor Non-common off-target(s) (drug1) : BE0000289 Alpha-2A adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000020 D(1A) dopamine receptor (1) BE0000145 D(1B) dopamine receptor (1) --------------------------------------------------- Drug1 : DB00413 Pramipexole Drug2 : DB05271 Rotigotine Pharmacological target (+,+) : BE0000756 D(2) dopamine receptor Pharmacological target (+,+) : BE0000581 D(3) dopamine receptor Pharmacological target (+,+) : BE0000389 D(4) dopamine receptor Non-common off-target(s) (drug1) : BE0000289 Alpha-2A adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000020 D(1A) dopamine receptor (1) BE0000145 D(1B) dopamine receptor (1) BE0000572 Alpha-2B adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00414 Acetohexamide Drug2 : DB00839 Tolazamide Pharmacological target (-,-) : BE0000644 ATP-sensitive inward rectifier potassium channel 1 --------------------------------------------------- Drug1 : DB00416 Metocurine Iodide Drug2 : DB00565 Cisatracurium Besylate Pharmacological target (-,-) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 --------------------------------------------------- Drug1 : DB00416 Metocurine Iodide Drug2 : DB00657 Mecamylamine Pharmacological target (-,-) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 --------------------------------------------------- Drug1 : DB00416 Metocurine Iodide Drug2 : DB00728 Rocuronium Pharmacological target (-,-) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 Non-common off-target(s) (drug2) : BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) --------------------------------------------------- Drug1 : DB00416 Metocurine Iodide Drug2 : DB00732 Atracurium Pharmacological target (-,-) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 --------------------------------------------------- Drug1 : DB00416 Metocurine Iodide Drug2 : DB00810 Biperiden Pharmacological target (-,-) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 Non-common off-target(s) (drug2) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) --------------------------------------------------- Drug1 : DB00416 Metocurine Iodide Drug2 : DB01135 Doxacurium chloride Pharmacological target (-,-) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 Non-common off-target(s) (drug2) : BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00416 Metocurine Iodide Drug2 : DB01199 Tubocurarine Pharmacological target (-,-) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 Non-common off-target(s) (drug2) : BE0000426 Acetylcholinesterase (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) --------------------------------------------------- Drug1 : DB00416 Metocurine Iodide Drug2 : DB01226 Mivacurium Pharmacological target (-,-) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) --------------------------------------------------- Drug1 : DB00416 Metocurine Iodide Drug2 : DB01336 Metocurine Pharmacological target (-,-) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 Non-common off-target(s) (drug2) : BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00416 Metocurine Iodide Drug2 : DB01337 Pancuronium Pharmacological target (-,-) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00416 Metocurine Iodide Drug2 : DB01338 Pipecuronium Pharmacological target (-,-) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00416 Metocurine Iodide Drug2 : DB01339 Vecuronium Pharmacological target (-,-) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 --------------------------------------------------- Drug1 : DB00418 Secobarbital Drug2 : DB01198 Zopiclone Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0004956 NMDA receptor (-1) Non-common off-target(s) (drug2) : BE0000736 Translocator protein (1) --------------------------------------------------- Drug1 : DB00418 Secobarbital Drug2 : DB01544 Flunitrazepam Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0004956 NMDA receptor (-1) Non-common off-target(s) (drug2) : BE0000736 Translocator protein (1) --------------------------------------------------- Drug1 : DB00419 Miglustat Drug2 : DB09039 Eliglustat Pharmacological target (-,-) : BE0000477 Ceramide glucosyltransferase --------------------------------------------------- Drug1 : DB00420 Promazine Drug2 : DB00433 Prochlorperazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00420 Promazine Drug2 : DB00490 Buspirone Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) Non-common off-target(s) (drug2) : BE0000291 5-hydroxytryptamine receptor 1A (1) --------------------------------------------------- Drug1 : DB00420 Promazine Drug2 : DB01184 Domperidone Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) Non-common off-target(s) (drug2) : BE0000581 D(3) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00420 Promazine Drug2 : DB01425 Alizapride Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00420 Promazine Drug2 : DB09018 Bromopride Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00421 Spironolactone Drug2 : DB00700 Eplerenone Pharmacological target (-,-) : BE0000668 Mineralocorticoid receptor Non-common off-target(s) (drug1) : BE0000794 Glucocorticoid receptor (-1) BE0000557 Progesterone receptor (1) BE0000132 Androgen receptor (-1) BE0003542 Cytochrome P450 11B2, mitochondrial (-1) BE0004886 17alpha-hydroxylase (-1) BE0004885 17,20-desmolase (-1) --------------------------------------------------- Drug1 : DB00422 Methylphenidate Drug2 : DB00745 Modafinil Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) Non-common off-target(s) (drug2) : BE0000575 Alpha-1B adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00422 Methylphenidate Drug2 : DB01255 Lisdexamfetamine Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) Non-common off-target(s) (drug2) : BE0000575 Alpha-1B adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00422 Methylphenidate Drug2 : DB01463 Fencamfamine Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB00424 Hyoscyamine Drug2 : DB00483 Gallamine Triethiodide Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) Non-common off-target(s) (drug2) : BE0000426 Acetylcholinesterase (-1) BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) --------------------------------------------------- Drug1 : DB00424 Hyoscyamine Drug2 : DB00670 Pirenzepine Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) --------------------------------------------------- Drug1 : DB00424 Hyoscyamine Drug2 : DB00728 Rocuronium Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) Non-common off-target(s) (drug2) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) --------------------------------------------------- Drug1 : DB00424 Hyoscyamine Drug2 : DB00771 Clidinium Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) --------------------------------------------------- Drug1 : DB00424 Hyoscyamine Drug2 : DB00782 Propantheline Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) --------------------------------------------------- Drug1 : DB00424 Hyoscyamine Drug2 : DB00810 Biperiden Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) Non-common off-target(s) (drug2) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) --------------------------------------------------- Drug1 : DB00424 Hyoscyamine Drug2 : DB00942 Cycrimine Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) --------------------------------------------------- Drug1 : DB00424 Hyoscyamine Drug2 : DB00979 Cyclopentolate Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) --------------------------------------------------- Drug1 : DB00424 Hyoscyamine Drug2 : DB01148 Flavoxate Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) --------------------------------------------------- Drug1 : DB00424 Hyoscyamine Drug2 : DB08801 Dimetindene Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) Non-common off-target(s) (drug2) : BE0000442 Histamine H1 receptor (-1) --------------------------------------------------- Drug1 : DB00425 Zolpidem Drug2 : DB00837 Progabide Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) Non-common off-target(s) (drug2) : BE0000217 Gamma-aminobutyric acid type B receptor subunit 1 (1) --------------------------------------------------- Drug1 : DB00425 Zolpidem Drug2 : DB00962 Zaleplon Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) --------------------------------------------------- Drug1 : DB00425 Zolpidem Drug2 : DB01107 Methyprylon Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) --------------------------------------------------- Drug1 : DB00425 Zolpidem Drug2 : DB01174 Phenobarbital Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0004956 NMDA receptor (-1) --------------------------------------------------- Drug1 : DB00425 Zolpidem Drug2 : DB01341 Dihydroquinidine barbiturate Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) --------------------------------------------------- Drug1 : DB00425 Zolpidem Drug2 : DB01437 Glutethimide Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) --------------------------------------------------- Drug1 : DB00427 Triprolidine Drug2 : DB00455 Loratadine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00427 Triprolidine Drug2 : DB00557 Hydroxyzine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00427 Triprolidine Drug2 : DB00637 Astemizole Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) --------------------------------------------------- Drug1 : DB00427 Triprolidine Drug2 : DB00719 Azatadine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00427 Triprolidine Drug2 : DB00737 Meclizine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00427 Triprolidine Drug2 : DB00748 Carbinoxamine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00427 Triprolidine Drug2 : DB00751 Epinastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000112 Histamine H2 receptor (-1) --------------------------------------------------- Drug1 : DB00427 Triprolidine Drug2 : DB00768 Olopatadine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0001090 Protein S100-A1 (-1) BE0001206 Protein S100-A12 (-1) BE0003602 Protein S100-A2 (-1) --------------------------------------------------- Drug1 : DB00427 Triprolidine Drug2 : DB00777 Propiomazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00427 Triprolidine Drug2 : DB00792 Tripelennamine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00427 Triprolidine Drug2 : DB00835 Brompheniramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00427 Triprolidine Drug2 : DB00902 Methdilazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00427 Triprolidine Drug2 : DB00950 Fexofenadine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00427 Triprolidine Drug2 : DB00967 Desloratadine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00427 Triprolidine Drug2 : DB00972 Azelastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00427 Triprolidine Drug2 : DB00985 Dimenhydrinate Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00427 Triprolidine Drug2 : DB01069 Promethazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00427 Triprolidine Drug2 : DB01071 Mequitazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00427 Triprolidine Drug2 : DB01075 Diphenhydramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00427 Triprolidine Drug2 : DB01084 Emedastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00427 Triprolidine Drug2 : DB01106 Levocabastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000464 Neurotensin receptor type 2 (-1) --------------------------------------------------- Drug1 : DB00427 Triprolidine Drug2 : DB01114 Chlorphenamine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB00427 Triprolidine Drug2 : DB01146 Diphenylpyraline Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB00427 Triprolidine Drug2 : DB01176 Cyclizine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000951 Estrogen sulfotransferase (-1) --------------------------------------------------- Drug1 : DB00427 Triprolidine Drug2 : DB01237 Bromodiphenhydramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00427 Triprolidine Drug2 : DB01246 Alimemazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00427 Triprolidine Drug2 : DB01615 Aceprometazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00427 Triprolidine Drug2 : DB01619 Phenindamine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00427 Triprolidine Drug2 : DB01620 Pheniramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00427 Triprolidine Drug2 : DB04837 Clofedanol Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00427 Triprolidine Drug2 : DB04890 Bepotastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00427 Triprolidine Drug2 : DB06691 Mepyramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00427 Triprolidine Drug2 : DB08799 Antazoline Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00427 Triprolidine Drug2 : DB08800 Chloropyramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00427 Triprolidine Drug2 : DB08801 Dimetindene Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00427 Triprolidine Drug2 : DB08802 Isothipendyl Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00427 Triprolidine Drug2 : DB08936 Chlorcyclizine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00429 Carboprost Tromethamine Drug2 : DB00770 Alprostadil Pharmacological target (+,+) : BE0000064 Prostaglandin E2 receptor EP1 subtype Non-common off-target(s) (drug2) : BE0000368 Prostaglandin E2 receptor EP2 subtype (1) --------------------------------------------------- Drug1 : DB00429 Carboprost Tromethamine Drug2 : DB01088 Iloprost Pharmacological target (+,+) : BE0000064 Prostaglandin E2 receptor EP1 subtype Non-common off-target(s) (drug2) : BE0000487 cAMP-specific 3',5'-cyclic phosphodiesterase 4B (1) BE0001287 cAMP-specific 3',5'-cyclic phosphodiesterase 4D (1) BE0001133 cAMP-specific 3',5'-cyclic phosphodiesterase 4A (1) BE0000475 Prostacyclin receptor (1) BE0002353 cAMP-specific 3',5'-cyclic phosphodiesterase 4C (1) --------------------------------------------------- Drug1 : DB00432 Trifluridine Drug2 : DB00440 Trimethoprim Pharmacological target (-,-) : BE0000324 Thymidylate synthase Non-common off-target(s) (drug2) : BE0000330 Dihydrofolate reductase (-1) --------------------------------------------------- Drug1 : DB00432 Trifluridine Drug2 : DB00650 Leucovorin Pharmacological target (-,-) : BE0000324 Thymidylate synthase --------------------------------------------------- Drug1 : DB00432 Trifluridine Drug2 : DB01101 Capecitabine Pharmacological target (-,-) : BE0000324 Thymidylate synthase --------------------------------------------------- Drug1 : DB00432 Trifluridine Drug2 : DB06813 Pralatrexate Pharmacological target (-,-) : BE0000324 Thymidylate synthase Non-common off-target(s) (drug2) : BE0000330 Dihydrofolate reductase (-1) --------------------------------------------------- Drug1 : DB00433 Prochlorperazine Drug2 : DB00450 Droperidol Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00433 Prochlorperazine Drug2 : DB00490 Buspirone Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug2) : BE0000291 5-hydroxytryptamine receptor 1A (1) --------------------------------------------------- Drug1 : DB00433 Prochlorperazine Drug2 : DB00502 Haloperidol Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug2) : BE0000417 Glutamate receptor ionotropic, NMDA 2B (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00433 Prochlorperazine Drug2 : DB00623 Fluphenazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug2) : BE0000020 D(1A) dopamine receptor (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00433 Prochlorperazine Drug2 : DB00734 Risperidone Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug2) : BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000659 5-hydroxytryptamine receptor 1D (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00433 Prochlorperazine Drug2 : DB00850 Perphenazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug2) : BE0000020 D(1A) dopamine receptor (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00433 Prochlorperazine Drug2 : DB00933 Mesoridazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug2) : BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB00433 Prochlorperazine Drug2 : DB01063 Acetophenazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug2) : BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00433 Prochlorperazine Drug2 : DB01184 Domperidone Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug2) : BE0000581 D(3) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00433 Prochlorperazine Drug2 : DB01224 Quetiapine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000145 D(1B) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00433 Prochlorperazine Drug2 : DB01233 Metoclopramide Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug2) : BE0000092 Muscarinic acetylcholine receptor M1 (1) BE0000311 5-hydroxytryptamine receptor 3A (1) BE0000084 5-hydroxytryptamine receptor 4 (1) --------------------------------------------------- Drug1 : DB00433 Prochlorperazine Drug2 : DB01403 Methotrimeprazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000145 D(1B) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00433 Prochlorperazine Drug2 : DB01425 Alizapride Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor --------------------------------------------------- Drug1 : DB00433 Prochlorperazine Drug2 : DB01618 Molindone Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug2) : BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB00433 Prochlorperazine Drug2 : DB04842 Fluspirilene Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug2) : BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000679 Voltage-dependent calcium channel gamma-1 subunit (-1) --------------------------------------------------- Drug1 : DB00433 Prochlorperazine Drug2 : DB04946 Iloperidone Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) BE0000342 Alpha-2C adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00433 Prochlorperazine Drug2 : DB06216 Asenapine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug2) : BE0000172 Beta-1 adrenergic receptor (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000694 Beta-2 adrenergic receptor (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000797 5-hydroxytryptamine receptor 1B (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000112 Histamine H2 receptor (-1) BE0004688 5-hydroxytryptamine receptor 5A (-1) --------------------------------------------------- Drug1 : DB00433 Prochlorperazine Drug2 : DB06288 Amisulpride Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug2) : BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000581 D(3) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00433 Prochlorperazine Drug2 : DB08815 Lurasidone Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug2) : BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000342 Alpha-2C adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00433 Prochlorperazine Drug2 : DB09018 Bromopride Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor --------------------------------------------------- Drug1 : DB00434 Cyproheptadine Drug2 : DB01242 Clomipramine Pharmacological target (-,-) : BE0000533 5-hydroxytryptamine receptor 2C Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000442 Histamine H1 receptor (-1) Non-common off-target(s) (drug2) : BE0000814 Glutathione S-transferase P (-1) BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) --------------------------------------------------- Drug1 : DB00434 Cyproheptadine Drug2 : DB06144 Sertindole Pharmacological target (-,-) : BE0000533 5-hydroxytryptamine receptor 2C Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000442 Histamine H1 receptor (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) --------------------------------------------------- Drug1 : DB00434 Cyproheptadine Drug2 : DB09016 Butriptyline Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) --------------------------------------------------- Drug1 : DB00435 Nitric Oxide Drug2 : DB01020 Isosorbide Mononitrate Pharmacological target (+,+) : BE0003578 Guanylate cyclase soluble subunit alpha-2 --------------------------------------------------- Drug1 : DB00436 Bendroflumethiazide Drug2 : DB00524 Metolazone Pharmacological target (-,-) : BE0000419 Solute carrier family 12 member 3 Non-common off-target(s) (drug1) : BE0000267 Carbonic anhydrase 1 (-1) BE0000322 Carbonic anhydrase 2 (-1) BE0000535 Carbonic anhydrase 4 (-1) BE0000553 Calcium-activated potassium channel subunit alpha-1 (1) --------------------------------------------------- Drug1 : DB00436 Bendroflumethiazide Drug2 : DB01324 Polythiazide Pharmacological target (-,-) : BE0000419 Solute carrier family 12 member 3 Non-common off-target(s) (drug1) : BE0000267 Carbonic anhydrase 1 (-1) BE0000322 Carbonic anhydrase 2 (-1) BE0000535 Carbonic anhydrase 4 (-1) BE0000553 Calcium-activated potassium channel subunit alpha-1 (1) --------------------------------------------------- Drug1 : DB00439 Cerivastatin Drug2 : DB00641 Simvastatin Pharmacological target (-,-) : BE0000574 3-hydroxy-3-methylglutaryl-coenzyme A reductase --------------------------------------------------- Drug1 : DB00439 Cerivastatin Drug2 : DB01076 Atorvastatin Pharmacological target (-,-) : BE0000574 3-hydroxy-3-methylglutaryl-coenzyme A reductase Non-common off-target(s) (drug2) : BE0003721 Aryl hydrocarbon receptor (1) BE0000854 Dipeptidyl peptidase 4 (-1) --------------------------------------------------- Drug1 : DB00439 Cerivastatin Drug2 : DB01095 Fluvastatin Pharmacological target (-,-) : BE0000574 3-hydroxy-3-methylglutaryl-coenzyme A reductase --------------------------------------------------- Drug1 : DB00439 Cerivastatin Drug2 : DB01098 Rosuvastatin Pharmacological target (-,-) : BE0000574 3-hydroxy-3-methylglutaryl-coenzyme A reductase --------------------------------------------------- Drug1 : DB00439 Cerivastatin Drug2 : DB06693 Mevastatin Pharmacological target (-,-) : BE0000574 3-hydroxy-3-methylglutaryl-coenzyme A reductase --------------------------------------------------- Drug1 : DB00439 Cerivastatin Drug2 : DB08860 Pitavastatin Pharmacological target (-,-) : BE0000574 3-hydroxy-3-methylglutaryl-coenzyme A reductase --------------------------------------------------- Drug1 : DB00440 Trimethoprim Drug2 : DB00650 Leucovorin Pharmacological target (-,-) : BE0000324 Thymidylate synthase Non-common off-target(s) (drug1) : BE0000330 Dihydrofolate reductase (-1) --------------------------------------------------- Drug1 : DB00440 Trimethoprim Drug2 : DB01101 Capecitabine Pharmacological target (-,-) : BE0000324 Thymidylate synthase Non-common off-target(s) (drug1) : BE0000330 Dihydrofolate reductase (-1) --------------------------------------------------- Drug1 : DB00441 Gemcitabine Drug2 : DB00631 Clofarabine Pharmacological target (-,-) : BE0000325 Ribonucleoside-diphosphate reductase large subunit Non-common off-target(s) (drug1) : BE0000324 Thymidylate synthase (-1) BE0000637 UMP-CMP kinase (-1) Non-common off-target(s) (drug2) : BE0000546 DNA polymerase alpha catalytic subunit (-1) --------------------------------------------------- Drug1 : DB00441 Gemcitabine Drug2 : DB01005 Hydroxyurea Pharmacological target (-,-) : BE0000325 Ribonucleoside-diphosphate reductase large subunit Non-common off-target(s) (drug1) : BE0000324 Thymidylate synthase (-1) BE0000637 UMP-CMP kinase (-1) --------------------------------------------------- Drug1 : DB00443 Betamethasone Drug2 : DB00547 Desoximetasone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00443 Betamethasone Drug2 : DB00588 Fluticasone Propionate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug2) : BE0000557 Progesterone receptor (1) BE0000668 Mineralocorticoid receptor (-1) BE0000657 Cytosolic phospholipase A2 (-1) --------------------------------------------------- Drug1 : DB00443 Betamethasone Drug2 : DB00591 Fluocinolone Acetonide Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00443 Betamethasone Drug2 : DB00596 Halobetasol Propionate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00443 Betamethasone Drug2 : DB00620 Triamcinolone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00443 Betamethasone Drug2 : DB00635 Prednisone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00443 Betamethasone Drug2 : DB00663 Flumethasone Pivalate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00443 Betamethasone Drug2 : DB00741 Hydrocortisone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug2) : BE0000422 Annexin A1 (1) --------------------------------------------------- Drug1 : DB00443 Betamethasone Drug2 : DB00764 Mometasone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00443 Betamethasone Drug2 : DB00769 Hydrocortamate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00443 Betamethasone Drug2 : DB00838 Clocortolone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00443 Betamethasone Drug2 : DB00846 Flurandrenolide Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00443 Betamethasone Drug2 : DB00860 Prednisolone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00443 Betamethasone Drug2 : DB00873 Loteprednol Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00443 Betamethasone Drug2 : DB00896 Rimexolone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00443 Betamethasone Drug2 : DB00959 Methylprednisolone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00443 Betamethasone Drug2 : DB01013 Clobetasol propionate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00443 Betamethasone Drug2 : DB01047 Fluocinonide Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug2) : BE0004659 Smoothened homolog (1) --------------------------------------------------- Drug1 : DB00443 Betamethasone Drug2 : DB01130 Prednicarbate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00443 Betamethasone Drug2 : DB01234 Dexamethasone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug2) : BE0000005 Nitric oxide synthase, inducible (-1) BE0000422 Annexin A1 (1) BE0000074 Nuclear receptor subfamily 0 group B member 1 (1) --------------------------------------------------- Drug1 : DB00443 Betamethasone Drug2 : DB01260 Desonide Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00443 Betamethasone Drug2 : DB01380 Cortisone acetate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00443 Betamethasone Drug2 : DB01384 Paramethasone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00443 Betamethasone Drug2 : DB01410 Ciclesonide Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00443 Betamethasone Drug2 : DB06781 Difluprednate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00443 Betamethasone Drug2 : DB08906 Fluticasone furoate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00444 Teniposide Drug2 : DB00694 Daunorubicin Pharmacological target (-,-) : BE0000742 DNA topoisomerase 2-alpha Non-common off-target(s) (drug2) : BE0002425 DNA topoisomerase 2-beta (-1) --------------------------------------------------- Drug1 : DB00444 Teniposide Drug2 : DB00773 Etoposide Pharmacological target (-,-) : BE0000742 DNA topoisomerase 2-alpha Non-common off-target(s) (drug2) : BE0002425 DNA topoisomerase 2-beta (-1) --------------------------------------------------- Drug1 : DB00444 Teniposide Drug2 : DB00997 Doxorubicin Pharmacological target (-,-) : BE0000742 DNA topoisomerase 2-alpha --------------------------------------------------- Drug1 : DB00444 Teniposide Drug2 : DB01137 Levofloxacin Pharmacological target (-,-) : BE0000742 DNA topoisomerase 2-alpha --------------------------------------------------- Drug1 : DB00444 Teniposide Drug2 : DB01177 Idarubicin Pharmacological target (-,-) : BE0000742 DNA topoisomerase 2-alpha --------------------------------------------------- Drug1 : DB00444 Teniposide Drug2 : DB01204 Mitoxantrone Pharmacological target (-,-) : BE0000742 DNA topoisomerase 2-alpha --------------------------------------------------- Drug1 : DB00444 Teniposide Drug2 : DB01208 Sparfloxacin Pharmacological target (-,-) : BE0000742 DNA topoisomerase 2-alpha --------------------------------------------------- Drug1 : DB00444 Teniposide Drug2 : DB04576 Fleroxacin Pharmacological target (-,-) : BE0000742 DNA topoisomerase 2-alpha --------------------------------------------------- Drug1 : DB00444 Teniposide Drug2 : DB09047 Finafloxacin Pharmacological target (-,-) : BE0000742 DNA topoisomerase 2-alpha --------------------------------------------------- Drug1 : DB00448 Lansoprazole Drug2 : DB00736 Esomeprazole Pharmacological target (-,-) : BE0000349 Potassium-transporting ATPase alpha chain 1 --------------------------------------------------- Drug1 : DB00448 Lansoprazole Drug2 : DB01129 Rabeprazole Pharmacological target (-,-) : BE0000349 Potassium-transporting ATPase alpha chain 1 --------------------------------------------------- Drug1 : DB00449 Dipivefrin Drug2 : DB00668 Epinephrine Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor Pharmacological target (+,+) : BE0000501 Alpha-1A adrenergic receptor Pharmacological target (+,+) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0002180 Cholinesterase (1) Non-common off-target(s) (drug2) : BE0000704 Tumor necrosis factor (-1) BE0000753 Phenylalanine-4-hydroxylase (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00449 Dipivefrin Drug2 : DB00865 Benzphetamine Pharmacological target (+,+) : BE0000501 Alpha-1A adrenergic receptor Pharmacological target (+,+) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0002180 Cholinesterase (1) BE0000694 Beta-2 adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (1) BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB00449 Dipivefrin Drug2 : DB00935 Oxymetazoline Pharmacological target (+,+) : BE0000501 Alpha-1A adrenergic receptor Pharmacological target (+,+) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0002180 Cholinesterase (1) BE0000694 Beta-2 adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00449 Dipivefrin Drug2 : DB00964 Apraclonidine Pharmacological target (+,+) : BE0000501 Alpha-1A adrenergic receptor Pharmacological target (+,+) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0002180 Cholinesterase (1) BE0000694 Beta-2 adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000572 Alpha-2B adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00449 Dipivefrin Drug2 : DB06694 Xylometazoline Pharmacological target (+,+) : BE0000501 Alpha-1A adrenergic receptor Pharmacological target (+,+) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0002180 Cholinesterase (1) BE0000694 Beta-2 adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00449 Dipivefrin Drug2 : DB06711 Naphazoline Pharmacological target (+,+) : BE0000501 Alpha-1A adrenergic receptor Pharmacological target (+,+) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0002180 Cholinesterase (1) BE0000694 Beta-2 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00450 Droperidol Drug2 : DB00490 Buspirone Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000501 Alpha-1A adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000291 5-hydroxytryptamine receptor 1A (1) --------------------------------------------------- Drug1 : DB00450 Droperidol Drug2 : DB00502 Haloperidol Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000501 Alpha-1A adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000417 Glutamate receptor ionotropic, NMDA 2B (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00450 Droperidol Drug2 : DB00623 Fluphenazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000501 Alpha-1A adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000020 D(1A) dopamine receptor (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00450 Droperidol Drug2 : DB00692 Phentolamine Pharmacological target (-,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000289 Alpha-2A adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00450 Droperidol Drug2 : DB00699 Nicergoline Pharmacological target (-,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00450 Droperidol Drug2 : DB00706 Tamsulosin Pharmacological target (-,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00450 Droperidol Drug2 : DB00797 Tolazoline Pharmacological target (-,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000442 Histamine H1 receptor (1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000112 Histamine H2 receptor (1) --------------------------------------------------- Drug1 : DB00450 Droperidol Drug2 : DB00831 Trifluoperazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Pharmacological target (-,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug2) : BE0000666 Neuron-specific vesicular protein calcyon (-1) BE0000418 Calmodulin (-1) BE0004350 Protein S100-A4 (-1) --------------------------------------------------- Drug1 : DB00450 Droperidol Drug2 : DB00850 Perphenazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000501 Alpha-1A adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000020 D(1A) dopamine receptor (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00450 Droperidol Drug2 : DB00875 Flupentixol Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Pharmacological target (-,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug2) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00450 Droperidol Drug2 : DB00925 Phenoxybenzamine Pharmacological target (-,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00450 Droperidol Drug2 : DB00933 Mesoridazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000501 Alpha-1A adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB00450 Droperidol Drug2 : DB01063 Acetophenazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000501 Alpha-1A adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00450 Droperidol Drug2 : DB01136 Carvedilol Pharmacological target (-,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000173 NADH dehydrogenase [ubiquinone] 1 subunit C2 (-1) BE0000172 Beta-1 adrenergic receptor (-1) BE0000694 Beta-2 adrenergic receptor (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0001114 Vascular cell adhesion protein 1 (-1) BE0001074 E-selectin (-1) --------------------------------------------------- Drug1 : DB00450 Droperidol Drug2 : DB01184 Domperidone Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000501 Alpha-1A adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000581 D(3) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00450 Droperidol Drug2 : DB01233 Metoclopramide Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000501 Alpha-1A adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000092 Muscarinic acetylcholine receptor M1 (1) BE0000311 5-hydroxytryptamine receptor 3A (1) BE0000084 5-hydroxytryptamine receptor 4 (1) --------------------------------------------------- Drug1 : DB00450 Droperidol Drug2 : DB01425 Alizapride Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000501 Alpha-1A adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00450 Droperidol Drug2 : DB01618 Molindone Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000501 Alpha-1A adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB00450 Droperidol Drug2 : DB04842 Fluspirilene Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000501 Alpha-1A adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000679 Voltage-dependent calcium channel gamma-1 subunit (-1) --------------------------------------------------- Drug1 : DB00450 Droperidol Drug2 : DB06207 Silodosin Pharmacological target (-,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00450 Droperidol Drug2 : DB06288 Amisulpride Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000501 Alpha-1A adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000581 D(3) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00450 Droperidol Drug2 : DB08815 Lurasidone Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000501 Alpha-1A adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000342 Alpha-2C adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00450 Droperidol Drug2 : DB09018 Bromopride Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000501 Alpha-1A adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00451 Levothyroxine Drug2 : DB00509 Dextrothyroxine Pharmacological target (+,+) : BE0000687 Thyroid hormone receptor alpha Pharmacological target (+,+) : BE0000315 Thyroid hormone receptor beta --------------------------------------------------- Drug1 : DB00451 Levothyroxine Drug2 : DB01583 Liotrix Pharmacological target (+,+) : BE0000687 Thyroid hormone receptor alpha Pharmacological target (+,+) : BE0000315 Thyroid hormone receptor beta --------------------------------------------------- Drug1 : DB00455 Loratadine Drug2 : DB00557 Hydroxyzine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00455 Loratadine Drug2 : DB00637 Astemizole Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) --------------------------------------------------- Drug1 : DB00455 Loratadine Drug2 : DB00719 Azatadine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00455 Loratadine Drug2 : DB00737 Meclizine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00455 Loratadine Drug2 : DB00748 Carbinoxamine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00455 Loratadine Drug2 : DB00751 Epinastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000112 Histamine H2 receptor (-1) --------------------------------------------------- Drug1 : DB00455 Loratadine Drug2 : DB00768 Olopatadine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0001090 Protein S100-A1 (-1) BE0001206 Protein S100-A12 (-1) BE0003602 Protein S100-A2 (-1) --------------------------------------------------- Drug1 : DB00455 Loratadine Drug2 : DB00777 Propiomazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00455 Loratadine Drug2 : DB00792 Tripelennamine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00455 Loratadine Drug2 : DB00835 Brompheniramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00455 Loratadine Drug2 : DB00902 Methdilazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00455 Loratadine Drug2 : DB00950 Fexofenadine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00455 Loratadine Drug2 : DB00967 Desloratadine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00455 Loratadine Drug2 : DB00972 Azelastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00455 Loratadine Drug2 : DB00985 Dimenhydrinate Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00455 Loratadine Drug2 : DB01069 Promethazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00455 Loratadine Drug2 : DB01071 Mequitazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00455 Loratadine Drug2 : DB01075 Diphenhydramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00455 Loratadine Drug2 : DB01084 Emedastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00455 Loratadine Drug2 : DB01106 Levocabastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000464 Neurotensin receptor type 2 (-1) --------------------------------------------------- Drug1 : DB00455 Loratadine Drug2 : DB01114 Chlorphenamine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB00455 Loratadine Drug2 : DB01146 Diphenylpyraline Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB00455 Loratadine Drug2 : DB01176 Cyclizine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000951 Estrogen sulfotransferase (-1) --------------------------------------------------- Drug1 : DB00455 Loratadine Drug2 : DB01237 Bromodiphenhydramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00455 Loratadine Drug2 : DB01246 Alimemazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00455 Loratadine Drug2 : DB01615 Aceprometazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00455 Loratadine Drug2 : DB01619 Phenindamine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00455 Loratadine Drug2 : DB01620 Pheniramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00455 Loratadine Drug2 : DB04837 Clofedanol Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00455 Loratadine Drug2 : DB04890 Bepotastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00455 Loratadine Drug2 : DB06691 Mepyramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00455 Loratadine Drug2 : DB08799 Antazoline Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00455 Loratadine Drug2 : DB08800 Chloropyramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00455 Loratadine Drug2 : DB08801 Dimetindene Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00455 Loratadine Drug2 : DB08802 Isothipendyl Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00455 Loratadine Drug2 : DB08936 Chlorcyclizine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00458 Imipramine Drug2 : DB00472 Fluoxetine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug1) : BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0003603 Potassium voltage-gated channel subfamily D member 2 (-1) BE0003604 Potassium voltage-gated channel subfamily D member 3 (-1) --------------------------------------------------- Drug1 : DB00458 Imipramine Drug2 : DB00476 Duloxetine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0003603 Potassium voltage-gated channel subfamily D member 2 (-1) BE0003604 Potassium voltage-gated channel subfamily D member 3 (-1) Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB00458 Imipramine Drug2 : DB00579 Mazindol Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0003603 Potassium voltage-gated channel subfamily D member 2 (-1) BE0003604 Potassium voltage-gated channel subfamily D member 3 (-1) Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB00458 Imipramine Drug2 : DB00830 Phenmetrazine Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0003603 Potassium voltage-gated channel subfamily D member 2 (-1) BE0003604 Potassium voltage-gated channel subfamily D member 3 (-1) Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB00458 Imipramine Drug2 : DB00937 Diethylpropion Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0003603 Potassium voltage-gated channel subfamily D member 2 (-1) BE0003604 Potassium voltage-gated channel subfamily D member 3 (-1) Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB00458 Imipramine Drug2 : DB01104 Sertraline Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug1) : BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0003603 Potassium voltage-gated channel subfamily D member 2 (-1) BE0003604 Potassium voltage-gated channel subfamily D member 3 (-1) Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB00458 Imipramine Drug2 : DB01105 Sibutramine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0003603 Potassium voltage-gated channel subfamily D member 2 (-1) BE0003604 Potassium voltage-gated channel subfamily D member 3 (-1) Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB00458 Imipramine Drug2 : DB01156 Bupropion Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0003603 Potassium voltage-gated channel subfamily D member 2 (-1) BE0003604 Potassium voltage-gated channel subfamily D member 3 (-1) Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0003585 Neuronal acetylcholine receptor subunit alpha-3 (-1) --------------------------------------------------- Drug1 : DB00458 Imipramine Drug2 : DB04896 Milnacipran Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0003603 Potassium voltage-gated channel subfamily D member 2 (-1) BE0003604 Potassium voltage-gated channel subfamily D member 3 (-1) Non-common off-target(s) (drug2) : BE0004956 NMDA receptor (-1) --------------------------------------------------- Drug1 : DB00458 Imipramine Drug2 : DB06700 Desvenlafaxine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0003603 Potassium voltage-gated channel subfamily D member 2 (-1) BE0003604 Potassium voltage-gated channel subfamily D member 3 (-1) --------------------------------------------------- Drug1 : DB00458 Imipramine Drug2 : DB08918 Levomilnacipran Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0003603 Potassium voltage-gated channel subfamily D member 2 (-1) BE0003604 Potassium voltage-gated channel subfamily D member 3 (-1) --------------------------------------------------- Drug1 : DB00459 Acitretin Drug2 : DB00523 Alitretinoin Pharmacological target (+,+) : BE0000144 Retinoic acid receptor gamma Pharmacological target (+,+) : BE0000206 Retinoic acid receptor beta Pharmacological target (+,+) : BE0000707 Retinoic acid receptor RXR-gamma Pharmacological target (+,+) : BE0000078 Retinoic acid receptor RXR-beta Pharmacological target (+,+) : BE0000663 Retinoic acid receptor alpha Pharmacological target (+,+) : BE0000412 Retinoic acid receptor RXR-alpha Non-common off-target(s) (drug1) : BE0000301 Retinol-binding protein 1 (1) --------------------------------------------------- Drug1 : DB00459 Acitretin Drug2 : DB00755 Tretinoin Pharmacological target (+,+) : BE0000144 Retinoic acid receptor gamma Pharmacological target (+,+) : BE0000707 Retinoic acid receptor RXR-gamma Pharmacological target (+,+) : BE0000078 Retinoic acid receptor RXR-beta Non-common off-target(s) (drug1) : BE0000301 Retinol-binding protein 1 (1) BE0000206 Retinoic acid receptor beta (1) BE0000663 Retinoic acid receptor alpha (1) BE0000412 Retinoic acid receptor RXR-alpha (1) Non-common off-target(s) (drug2) : BE0000653 Retinoic acid receptor responder protein 1 (1) --------------------------------------------------- Drug1 : DB00459 Acitretin Drug2 : DB00799 Tazarotene Pharmacological target (+,+) : BE0000144 Retinoic acid receptor gamma Pharmacological target (+,+) : BE0000206 Retinoic acid receptor beta Pharmacological target (+,+) : BE0000078 Retinoic acid receptor RXR-beta Pharmacological target (+,+) : BE0000663 Retinoic acid receptor alpha Non-common off-target(s) (drug1) : BE0000301 Retinol-binding protein 1 (1) BE0000707 Retinoic acid receptor RXR-gamma (1) BE0000412 Retinoic acid receptor RXR-alpha (1) --------------------------------------------------- Drug1 : DB00459 Acitretin Drug2 : DB00926 Etretinate Pharmacological target (+,+) : BE0000144 Retinoic acid receptor gamma Pharmacological target (+,+) : BE0000206 Retinoic acid receptor beta Pharmacological target (+,+) : BE0000707 Retinoic acid receptor RXR-gamma Pharmacological target (+,+) : BE0000078 Retinoic acid receptor RXR-beta Pharmacological target (+,+) : BE0000663 Retinoic acid receptor alpha Pharmacological target (+,+) : BE0000412 Retinoic acid receptor RXR-alpha Non-common off-target(s) (drug1) : BE0000301 Retinol-binding protein 1 (1) --------------------------------------------------- Drug1 : DB00461 Nabumetone Drug2 : DB00482 Celecoxib Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) Non-common off-target(s) (drug2) : BE0001193 3-phosphoinositide-dependent protein kinase 1 (-1) --------------------------------------------------- Drug1 : DB00461 Nabumetone Drug2 : DB00533 Rofecoxib Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) --------------------------------------------------- Drug1 : DB00461 Nabumetone Drug2 : DB00580 Valdecoxib Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) --------------------------------------------------- Drug1 : DB00461 Nabumetone Drug2 : DB01050 Ibuprofen Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) Non-common off-target(s) (drug2) : BE0001088 Tissue-type plasminogen activator (-1) BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0001195 Cystic fibrosis transmembrane conductance regulator (-1) --------------------------------------------------- Drug1 : DB00461 Nabumetone Drug2 : DB01628 Etoricoxib Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) --------------------------------------------------- Drug1 : DB00461 Nabumetone Drug2 : DB04552 Niflumic Acid Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) Non-common off-target(s) (drug2) : BE0003997 Phospholipase A2 (-1) BE0002376 Chloride channel protein ClC-Ka (1) --------------------------------------------------- Drug1 : DB00461 Nabumetone Drug2 : DB04743 Nimesulide Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) --------------------------------------------------- Drug1 : DB00462 Methylscopolamine bromide Drug2 : DB00483 Gallamine Triethiodide Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) Non-common off-target(s) (drug2) : BE0000426 Acetylcholinesterase (-1) BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) --------------------------------------------------- Drug1 : DB00462 Methylscopolamine bromide Drug2 : DB00670 Pirenzepine Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00462 Methylscopolamine bromide Drug2 : DB00728 Rocuronium Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) Non-common off-target(s) (drug2) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) --------------------------------------------------- Drug1 : DB00462 Methylscopolamine bromide Drug2 : DB00771 Clidinium Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00462 Methylscopolamine bromide Drug2 : DB00782 Propantheline Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00462 Methylscopolamine bromide Drug2 : DB00810 Biperiden Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) Non-common off-target(s) (drug2) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) --------------------------------------------------- Drug1 : DB00462 Methylscopolamine bromide Drug2 : DB00942 Cycrimine Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00462 Methylscopolamine bromide Drug2 : DB00979 Cyclopentolate Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00462 Methylscopolamine bromide Drug2 : DB01148 Flavoxate Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) --------------------------------------------------- Drug1 : DB00462 Methylscopolamine bromide Drug2 : DB08801 Dimetindene Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) Non-common off-target(s) (drug2) : BE0000442 Histamine H1 receptor (-1) --------------------------------------------------- Drug1 : DB00463 Metharbital Drug2 : DB01198 Zopiclone Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0004797 GABA-A receptor (anion channel) (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0000736 Translocator protein (1) --------------------------------------------------- Drug1 : DB00463 Metharbital Drug2 : DB01544 Flunitrazepam Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0004797 GABA-A receptor (anion channel) (1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) Non-common off-target(s) (drug2) : BE0000736 Translocator protein (1) --------------------------------------------------- Drug1 : DB00465 Ketorolac Drug2 : DB00482 Celecoxib Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) Non-common off-target(s) (drug2) : BE0001193 3-phosphoinositide-dependent protein kinase 1 (-1) --------------------------------------------------- Drug1 : DB00465 Ketorolac Drug2 : DB00533 Rofecoxib Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) --------------------------------------------------- Drug1 : DB00465 Ketorolac Drug2 : DB00580 Valdecoxib Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) --------------------------------------------------- Drug1 : DB00465 Ketorolac Drug2 : DB01050 Ibuprofen Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) Non-common off-target(s) (drug2) : BE0001088 Tissue-type plasminogen activator (-1) BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0001195 Cystic fibrosis transmembrane conductance regulator (-1) --------------------------------------------------- Drug1 : DB00465 Ketorolac Drug2 : DB01628 Etoricoxib Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) --------------------------------------------------- Drug1 : DB00465 Ketorolac Drug2 : DB04552 Niflumic Acid Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) Non-common off-target(s) (drug2) : BE0003997 Phospholipase A2 (-1) BE0002376 Chloride channel protein ClC-Ka (1) --------------------------------------------------- Drug1 : DB00465 Ketorolac Drug2 : DB04743 Nimesulide Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) --------------------------------------------------- Drug1 : DB00466 Picrotoxin Drug2 : DB00474 Methohexital Pharmacological target (-,-) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000414 Glycine receptor subunit alpha-3 (-1) BE0000745 Glycine receptor subunit alpha-2 (-1) BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 (-1) --------------------------------------------------- Drug1 : DB00469 Tenoxicam Drug2 : DB00482 Celecoxib Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) Non-common off-target(s) (drug2) : BE0001193 3-phosphoinositide-dependent protein kinase 1 (-1) --------------------------------------------------- Drug1 : DB00469 Tenoxicam Drug2 : DB00533 Rofecoxib Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) --------------------------------------------------- Drug1 : DB00469 Tenoxicam Drug2 : DB00580 Valdecoxib Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) --------------------------------------------------- Drug1 : DB00469 Tenoxicam Drug2 : DB01050 Ibuprofen Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) Non-common off-target(s) (drug2) : BE0001088 Tissue-type plasminogen activator (-1) BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0001195 Cystic fibrosis transmembrane conductance regulator (-1) --------------------------------------------------- Drug1 : DB00469 Tenoxicam Drug2 : DB01628 Etoricoxib Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) --------------------------------------------------- Drug1 : DB00469 Tenoxicam Drug2 : DB04552 Niflumic Acid Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) Non-common off-target(s) (drug2) : BE0003997 Phospholipase A2 (-1) BE0002376 Chloride channel protein ClC-Ka (1) --------------------------------------------------- Drug1 : DB00469 Tenoxicam Drug2 : DB04743 Nimesulide Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) --------------------------------------------------- Drug1 : DB00471 Montelukast Drug2 : DB00549 Zafirlukast Pharmacological target (-,-) : BE0000705 Cysteinyl leukotriene receptor 1 --------------------------------------------------- Drug1 : DB00471 Montelukast Drug2 : DB00587 Cinalukast Pharmacological target (-,-) : BE0000705 Cysteinyl leukotriene receptor 1 --------------------------------------------------- Drug1 : DB00471 Montelukast Drug2 : DB00716 Nedocromil Pharmacological target (-,-) : BE0000705 Cysteinyl leukotriene receptor 1 Non-common off-target(s) (drug2) : BE0000099 Cysteinyl leukotriene receptor 2 (-1) BE0000995 fMet-Leu-Phe receptor (-1) --------------------------------------------------- Drug1 : DB00471 Montelukast Drug2 : DB01411 Pranlukast Pharmacological target (-,-) : BE0000705 Cysteinyl leukotriene receptor 1 Non-common off-target(s) (drug2) : BE0001208 Interleukin-5 (-1) --------------------------------------------------- Drug1 : DB00472 Fluoxetine Drug2 : DB00476 Duloxetine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB00472 Fluoxetine Drug2 : DB00543 Amoxapine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug2) : BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000756 D(2) dopamine receptor (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000797 5-hydroxytryptamine receptor 1B (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0004864 Alpha-2 adrenergic receptor (-1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0004863 Alpha-1 adrenergic receptor (-1) BE0004890 Muscarinic acetylcholine receptor (-1) --------------------------------------------------- Drug1 : DB00472 Fluoxetine Drug2 : DB00715 Paroxetine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug2) : BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00472 Fluoxetine Drug2 : DB00726 Trimipramine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (1) BE0000289 Alpha-2A adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00472 Fluoxetine Drug2 : DB01104 Sertraline Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB00472 Fluoxetine Drug2 : DB01175 Escitalopram Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) --------------------------------------------------- Drug1 : DB00472 Fluoxetine Drug2 : DB01191 Dexfenfluramine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug2) : BE0000533 5-hydroxytryptamine receptor 2C (1) --------------------------------------------------- Drug1 : DB00472 Fluoxetine Drug2 : DB04896 Milnacipran Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug2) : BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0004956 NMDA receptor (-1) --------------------------------------------------- Drug1 : DB00472 Fluoxetine Drug2 : DB06700 Desvenlafaxine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug2) : BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB00472 Fluoxetine Drug2 : DB08918 Levomilnacipran Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug2) : BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB00473 Hexylcaine Drug2 : DB00532 Mephenytoin Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0000177 Sodium channel protein type 10 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00473 Hexylcaine Drug2 : DB00564 Carbamazepine Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0000177 Sodium channel protein type 10 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00473 Hexylcaine Drug2 : DB00680 Moricizine Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0000177 Sodium channel protein type 10 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00473 Hexylcaine Drug2 : DB00740 Riluzole Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0000177 Sodium channel protein type 10 subunit alpha (-1) Non-common off-target(s) (drug2) : BE0000030 Cystine/glutamate transporter (1) --------------------------------------------------- Drug1 : DB00473 Hexylcaine Drug2 : DB00750 Prilocaine Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0000177 Sodium channel protein type 10 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00473 Hexylcaine Drug2 : DB00754 Ethotoin Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0000177 Sodium channel protein type 10 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00473 Hexylcaine Drug2 : DB00776 Oxcarbazepine Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0000177 Sodium channel protein type 10 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00473 Hexylcaine Drug2 : DB00908 Quinidine Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0000177 Sodium channel protein type 10 subunit alpha (-1) Non-common off-target(s) (drug2) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000154 Potassium channel subfamily K member 1 (-1) BE0000680 Potassium channel subfamily K member 6 (-1) --------------------------------------------------- Drug1 : DB00473 Hexylcaine Drug2 : DB01056 Tocainide Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0000177 Sodium channel protein type 10 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00473 Hexylcaine Drug2 : DB01182 Propafenone Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0000177 Sodium channel protein type 10 subunit alpha (-1) Non-common off-target(s) (drug2) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) --------------------------------------------------- Drug1 : DB00473 Hexylcaine Drug2 : DB01195 Flecainide Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0000177 Sodium channel protein type 10 subunit alpha (-1) Non-common off-target(s) (drug2) : BE0002083 Sodium channel protein type 4 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00473 Hexylcaine Drug2 : DB01228 Encainide Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0000177 Sodium channel protein type 10 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00473 Hexylcaine Drug2 : DB01320 Fosphenytoin Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0000177 Sodium channel protein type 10 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00473 Hexylcaine Drug2 : DB01426 Ajmaline Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0000177 Sodium channel protein type 10 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00473 Hexylcaine Drug2 : DB01429 Aprindine Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0000177 Sodium channel protein type 10 subunit alpha (-1) Non-common off-target(s) (drug2) : BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00475 Chlordiazepoxide Drug2 : DB00628 Clorazepate Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug2) : BE0000736 Translocator protein (1) --------------------------------------------------- Drug1 : DB00475 Chlordiazepoxide Drug2 : DB01068 Clonazepam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) --------------------------------------------------- Drug1 : DB00475 Chlordiazepoxide Drug2 : DB01107 Methyprylon Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug2) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) --------------------------------------------------- Drug1 : DB00475 Chlordiazepoxide Drug2 : DB01159 Halothane Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug2) : BE0000534 Glutamate receptor ionotropic, NMDA 3B (-1) BE0000760 Glutamate receptor ionotropic, NMDA 2A (-1) BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000503 NADH-ubiquinone oxidoreductase chain 1 (-1) BE0000415 Intermediate conductance calcium-activated potassium channel protein 4 (-1) BE0000553 Calcium-activated potassium channel subunit alpha-1 (-1) BE0001028 G protein-activated inward rectifier potassium channel 1 (-1) BE0001030 G protein-activated inward rectifier potassium channel 2 (-1) --------------------------------------------------- Drug1 : DB00475 Chlordiazepoxide Drug2 : DB01437 Glutethimide Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug2) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) --------------------------------------------------- Drug1 : DB00476 Duloxetine Drug2 : DB00540 Nortriptyline Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) Non-common off-target(s) (drug2) : BE0004872 Beta adrenergic receptor (-1) BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0004864 Alpha-2 adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00476 Duloxetine Drug2 : DB00934 Maprotiline Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000442 Histamine H1 receptor (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0004864 Alpha-2 adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0004863 Alpha-1 adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00476 Duloxetine Drug2 : DB01151 Desipramine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000694 Beta-2 adrenergic receptor (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000442 Histamine H1 receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0004863 Alpha-1 adrenergic receptor (-1) BE0000973 Sphingomyelin phosphodiesterase (-1) --------------------------------------------------- Drug1 : DB00476 Duloxetine Drug2 : DB01191 Dexfenfluramine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) Non-common off-target(s) (drug2) : BE0000533 5-hydroxytryptamine receptor 2C (1) --------------------------------------------------- Drug1 : DB00476 Duloxetine Drug2 : DB01579 Phendimetrazine Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00476 Duloxetine Drug2 : DB04896 Milnacipran Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) Non-common off-target(s) (drug2) : BE0004956 NMDA receptor (-1) --------------------------------------------------- Drug1 : DB00476 Duloxetine Drug2 : DB06700 Desvenlafaxine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB00476 Duloxetine Drug2 : DB08918 Levomilnacipran Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB00477 Chlorpromazine Drug2 : DB00679 Thioridazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Pharmacological target (-,-) : BE0000501 Alpha-1A adrenergic receptor Pharmacological target (-,-) : BE0000575 Alpha-1B adrenergic receptor Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Pharmacological target (-,-) : BE0000020 D(1A) dopamine receptor Non-common off-target(s) (drug1) : BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) Non-common off-target(s) (drug2) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) --------------------------------------------------- Drug1 : DB00477 Chlorpromazine Drug2 : DB00875 Flupentixol Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Pharmacological target (-,-) : BE0000501 Alpha-1A adrenergic receptor Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Pharmacological target (-,-) : BE0000020 D(1A) dopamine receptor Non-common off-target(s) (drug1) : BE0000575 Alpha-1B adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) Non-common off-target(s) (drug2) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) --------------------------------------------------- Drug1 : DB00477 Chlorpromazine Drug2 : DB01621 Pipotiazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Pharmacological target (-,-) : BE0000291 5-hydroxytryptamine receptor 1A Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Pharmacological target (-,-) : BE0000020 D(1A) dopamine receptor Non-common off-target(s) (drug1) : BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) --------------------------------------------------- Drug1 : DB00481 Raloxifene Drug2 : DB00603 Medroxyprogesterone Acetate Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug1) : BE0000792 Estrogen receptor beta (1) Non-common off-target(s) (drug2) : BE0000557 Progesterone receptor (1) --------------------------------------------------- Drug1 : DB00481 Raloxifene Drug2 : DB00655 Estrone Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug1) : BE0000792 Estrogen receptor beta (1) --------------------------------------------------- Drug1 : DB00481 Raloxifene Drug2 : DB00783 Estradiol Pharmacological target (+,+) : BE0000123 Estrogen receptor Pharmacological target (+,+) : BE0000792 Estrogen receptor beta --------------------------------------------------- Drug1 : DB00481 Raloxifene Drug2 : DB00823 Ethynodiol Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug1) : BE0000792 Estrogen receptor beta (1) Non-common off-target(s) (drug2) : BE0000557 Progesterone receptor (1) --------------------------------------------------- Drug1 : DB00481 Raloxifene Drug2 : DB00890 Dienestrol Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug1) : BE0000792 Estrogen receptor beta (1) --------------------------------------------------- Drug1 : DB00481 Raloxifene Drug2 : DB00957 Norgestimate Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug1) : BE0000792 Estrogen receptor beta (1) Non-common off-target(s) (drug2) : BE0000557 Progesterone receptor (1) --------------------------------------------------- Drug1 : DB00481 Raloxifene Drug2 : DB00977 Ethinyl Estradiol Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug1) : BE0000792 Estrogen receptor beta (1) Non-common off-target(s) (drug2) : BE0000956 Nuclear receptor subfamily 1 group I member 2 (1) --------------------------------------------------- Drug1 : DB00481 Raloxifene Drug2 : DB01357 Mestranol Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug1) : BE0000792 Estrogen receptor beta (1) --------------------------------------------------- Drug1 : DB00481 Raloxifene Drug2 : DB04575 Quinestrol Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug1) : BE0000792 Estrogen receptor beta (1) --------------------------------------------------- Drug1 : DB00482 Celecoxib Drug2 : DB00500 Tolmetin Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0001193 3-phosphoinositide-dependent protein kinase 1 (-1) Non-common off-target(s) (drug2) : BE0000017 Prostaglandin G/H synthase 1 (-1) --------------------------------------------------- Drug1 : DB00482 Celecoxib Drug2 : DB00533 Rofecoxib Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0001193 3-phosphoinositide-dependent protein kinase 1 (-1) --------------------------------------------------- Drug1 : DB00482 Celecoxib Drug2 : DB00554 Piroxicam Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0001193 3-phosphoinositide-dependent protein kinase 1 (-1) Non-common off-target(s) (drug2) : BE0000017 Prostaglandin G/H synthase 1 (-1) --------------------------------------------------- Drug1 : DB00482 Celecoxib Drug2 : DB00573 Fenoprofen Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0001193 3-phosphoinositide-dependent protein kinase 1 (-1) Non-common off-target(s) (drug2) : BE0000017 Prostaglandin G/H synthase 1 (-1) --------------------------------------------------- Drug1 : DB00482 Celecoxib Drug2 : DB00580 Valdecoxib Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0001193 3-phosphoinositide-dependent protein kinase 1 (-1) --------------------------------------------------- Drug1 : DB00482 Celecoxib Drug2 : DB00605 Sulindac Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0001193 3-phosphoinositide-dependent protein kinase 1 (-1) Non-common off-target(s) (drug2) : BE0000017 Prostaglandin G/H synthase 1 (-1) BE0000747 Aldose reductase (-1) BE0001007 Peroxisome proliferator-activated receptor delta (-1) BE0003561 Prostaglandin D2 receptor 2 (-1) BE0001062 Mitogen-activated protein kinase 3 (-1) --------------------------------------------------- Drug1 : DB00482 Celecoxib Drug2 : DB00712 Flurbiprofen Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0001193 3-phosphoinositide-dependent protein kinase 1 (-1) Non-common off-target(s) (drug2) : BE0000017 Prostaglandin G/H synthase 1 (-1) --------------------------------------------------- Drug1 : DB00482 Celecoxib Drug2 : DB00749 Etodolac Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0001193 3-phosphoinositide-dependent protein kinase 1 (-1) Non-common off-target(s) (drug2) : BE0000017 Prostaglandin G/H synthase 1 (-1) --------------------------------------------------- Drug1 : DB00482 Celecoxib Drug2 : DB00784 Mefenamic acid Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0001193 3-phosphoinositide-dependent protein kinase 1 (-1) Non-common off-target(s) (drug2) : BE0000017 Prostaglandin G/H synthase 1 (-1) --------------------------------------------------- Drug1 : DB00482 Celecoxib Drug2 : DB00788 Naproxen Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0001193 3-phosphoinositide-dependent protein kinase 1 (-1) Non-common off-target(s) (drug2) : BE0000017 Prostaglandin G/H synthase 1 (-1) --------------------------------------------------- Drug1 : DB00482 Celecoxib Drug2 : DB00814 Meloxicam Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0001193 3-phosphoinositide-dependent protein kinase 1 (-1) Non-common off-target(s) (drug2) : BE0000017 Prostaglandin G/H synthase 1 (-1) --------------------------------------------------- Drug1 : DB00482 Celecoxib Drug2 : DB00821 Carprofen Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0001193 3-phosphoinositide-dependent protein kinase 1 (-1) Non-common off-target(s) (drug2) : BE0000017 Prostaglandin G/H synthase 1 (-1) --------------------------------------------------- Drug1 : DB00482 Celecoxib Drug2 : DB00861 Diflunisal Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0001193 3-phosphoinositide-dependent protein kinase 1 (-1) Non-common off-target(s) (drug2) : BE0000017 Prostaglandin G/H synthase 1 (-1) --------------------------------------------------- Drug1 : DB00482 Celecoxib Drug2 : DB00870 Suprofen Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0001193 3-phosphoinositide-dependent protein kinase 1 (-1) Non-common off-target(s) (drug2) : BE0000017 Prostaglandin G/H synthase 1 (-1) --------------------------------------------------- Drug1 : DB00482 Celecoxib Drug2 : DB00936 Salicylic acid Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0001193 3-phosphoinositide-dependent protein kinase 1 (-1) Non-common off-target(s) (drug2) : BE0000017 Prostaglandin G/H synthase 1 (-1) BE0000126 Aldo-keto reductase family 1 member C1 (-1) --------------------------------------------------- Drug1 : DB00482 Celecoxib Drug2 : DB00945 Acetylsalicylic acid Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0001193 3-phosphoinositide-dependent protein kinase 1 (-1) Non-common off-target(s) (drug2) : BE0000017 Prostaglandin G/H synthase 1 (-1) BE0000126 Aldo-keto reductase family 1 member C1 (-1) BE0004907 5'-AMP-activated protein kinase (1) BE0004903 Nuclear factor NF-kappa-B (-1) --------------------------------------------------- Drug1 : DB00482 Celecoxib Drug2 : DB00963 Bromfenac Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0001193 3-phosphoinositide-dependent protein kinase 1 (-1) Non-common off-target(s) (drug2) : BE0000017 Prostaglandin G/H synthase 1 (-1) --------------------------------------------------- Drug1 : DB00482 Celecoxib Drug2 : DB00991 Oxaprozin Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0001193 3-phosphoinositide-dependent protein kinase 1 (-1) Non-common off-target(s) (drug2) : BE0000017 Prostaglandin G/H synthase 1 (-1) --------------------------------------------------- Drug1 : DB00482 Celecoxib Drug2 : DB01009 Ketoprofen Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0001193 3-phosphoinositide-dependent protein kinase 1 (-1) Non-common off-target(s) (drug2) : BE0000017 Prostaglandin G/H synthase 1 (-1) --------------------------------------------------- Drug1 : DB00482 Celecoxib Drug2 : DB01050 Ibuprofen Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0001193 3-phosphoinositide-dependent protein kinase 1 (-1) Non-common off-target(s) (drug2) : BE0001088 Tissue-type plasminogen activator (-1) BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0001195 Cystic fibrosis transmembrane conductance regulator (-1) --------------------------------------------------- Drug1 : DB00482 Celecoxib Drug2 : DB01283 Lumiracoxib Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0001193 3-phosphoinositide-dependent protein kinase 1 (-1) Non-common off-target(s) (drug2) : BE0000017 Prostaglandin G/H synthase 1 (-1) --------------------------------------------------- Drug1 : DB00482 Celecoxib Drug2 : DB01397 Magnesium salicylate Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0001193 3-phosphoinositide-dependent protein kinase 1 (-1) Non-common off-target(s) (drug2) : BE0000017 Prostaglandin G/H synthase 1 (-1) --------------------------------------------------- Drug1 : DB00482 Celecoxib Drug2 : DB01398 Salicylate-sodium Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0001193 3-phosphoinositide-dependent protein kinase 1 (-1) Non-common off-target(s) (drug2) : BE0000017 Prostaglandin G/H synthase 1 (-1) --------------------------------------------------- Drug1 : DB00482 Celecoxib Drug2 : DB01399 Salsalate Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0001193 3-phosphoinositide-dependent protein kinase 1 (-1) Non-common off-target(s) (drug2) : BE0000017 Prostaglandin G/H synthase 1 (-1) --------------------------------------------------- Drug1 : DB00482 Celecoxib Drug2 : DB01600 Tiaprofenic acid Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0001193 3-phosphoinositide-dependent protein kinase 1 (-1) Non-common off-target(s) (drug2) : BE0000017 Prostaglandin G/H synthase 1 (-1) --------------------------------------------------- Drug1 : DB00482 Celecoxib Drug2 : DB01628 Etoricoxib Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0001193 3-phosphoinositide-dependent protein kinase 1 (-1) --------------------------------------------------- Drug1 : DB00482 Celecoxib Drug2 : DB04552 Niflumic Acid Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0001193 3-phosphoinositide-dependent protein kinase 1 (-1) Non-common off-target(s) (drug2) : BE0003997 Phospholipase A2 (-1) BE0002376 Chloride channel protein ClC-Ka (1) --------------------------------------------------- Drug1 : DB00482 Celecoxib Drug2 : DB04743 Nimesulide Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0001193 3-phosphoinositide-dependent protein kinase 1 (-1) --------------------------------------------------- Drug1 : DB00482 Celecoxib Drug2 : DB06725 Lornoxicam Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0001193 3-phosphoinositide-dependent protein kinase 1 (-1) Non-common off-target(s) (drug2) : BE0000017 Prostaglandin G/H synthase 1 (-1) --------------------------------------------------- Drug1 : DB00483 Gallamine Triethiodide Drug2 : DB00545 Pyridostigmine Pharmacological target (-,-) : BE0000426 Acetylcholinesterase Non-common off-target(s) (drug1) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) Non-common off-target(s) (drug2) : BE0002180 Cholinesterase (-1) --------------------------------------------------- Drug1 : DB00483 Gallamine Triethiodide Drug2 : DB00674 Galantamine Pharmacological target (-,-) : BE0000426 Acetylcholinesterase Non-common off-target(s) (drug1) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) Non-common off-target(s) (drug2) : BE0002180 Cholinesterase (-1) --------------------------------------------------- Drug1 : DB00483 Gallamine Triethiodide Drug2 : DB00677 Isoflurophate Pharmacological target (-,-) : BE0000426 Acetylcholinesterase Non-common off-target(s) (drug1) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) Non-common off-target(s) (drug2) : BE0002180 Cholinesterase (-1) --------------------------------------------------- Drug1 : DB00483 Gallamine Triethiodide Drug2 : DB00843 Donepezil Pharmacological target (-,-) : BE0000426 Acetylcholinesterase Non-common off-target(s) (drug1) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00483 Gallamine Triethiodide Drug2 : DB00944 Demecarium Pharmacological target (-,-) : BE0000426 Acetylcholinesterase Non-common off-target(s) (drug1) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) Non-common off-target(s) (drug2) : BE0002180 Cholinesterase (-1) --------------------------------------------------- Drug1 : DB00483 Gallamine Triethiodide Drug2 : DB00981 Physostigmine Pharmacological target (-,-) : BE0000426 Acetylcholinesterase Non-common off-target(s) (drug1) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00483 Gallamine Triethiodide Drug2 : DB00989 Rivastigmine Pharmacological target (-,-) : BE0000426 Acetylcholinesterase Non-common off-target(s) (drug1) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) Non-common off-target(s) (drug2) : BE0002180 Cholinesterase (-1) --------------------------------------------------- Drug1 : DB00483 Gallamine Triethiodide Drug2 : DB01010 Edrophonium Pharmacological target (-,-) : BE0000426 Acetylcholinesterase Non-common off-target(s) (drug1) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) Non-common off-target(s) (drug2) : BE0002180 Cholinesterase (-1) --------------------------------------------------- Drug1 : DB00483 Gallamine Triethiodide Drug2 : DB01122 Ambenonium Pharmacological target (-,-) : BE0000426 Acetylcholinesterase Non-common off-target(s) (drug1) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00483 Gallamine Triethiodide Drug2 : DB01148 Flavoxate Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000426 Acetylcholinesterase (-1) BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) Non-common off-target(s) (drug2) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) --------------------------------------------------- Drug1 : DB00483 Gallamine Triethiodide Drug2 : DB01400 Neostigmine Pharmacological target (-,-) : BE0000426 Acetylcholinesterase Non-common off-target(s) (drug1) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00483 Gallamine Triethiodide Drug2 : DB08801 Dimetindene Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000426 Acetylcholinesterase (-1) BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) Non-common off-target(s) (drug2) : BE0000442 Histamine H1 receptor (-1) --------------------------------------------------- Drug1 : DB00483 Gallamine Triethiodide Drug2 : DB08996 Dimetacrine Pharmacological target (-,-) : BE0000426 Acetylcholinesterase Non-common off-target(s) (drug1) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00483 Gallamine Triethiodide Drug2 : DB09076 Umeclidinium Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000426 Acetylcholinesterase (-1) BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00484 Brimonidine Drug2 : DB00575 Clonidine Pharmacological target (+,+) : BE0000289 Alpha-2A adrenergic receptor Pharmacological target (+,+) : BE0000572 Alpha-2B adrenergic receptor Pharmacological target (+,+) : BE0000342 Alpha-2C adrenergic receptor Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00489 Sotalol Drug2 : DB00598 Labetalol Pharmacological target (-,-) : BE0000172 Beta-1 adrenergic receptor Pharmacological target (-,-) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) Non-common off-target(s) (drug2) : BE0004863 Alpha-1 adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00489 Sotalol Drug2 : DB00866 Alprenolol Pharmacological target (-,-) : BE0000172 Beta-1 adrenergic receptor Pharmacological target (-,-) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) Non-common off-target(s) (drug2) : BE0000291 5-hydroxytryptamine receptor 1A (-1) --------------------------------------------------- Drug1 : DB00489 Sotalol Drug2 : DB01118 Amiodarone Pharmacological target (-,-) : BE0000172 Beta-1 adrenergic receptor Pharmacological target (-,-) : BE0000090 Potassium voltage-gated channel subfamily H member 2 Non-common off-target(s) (drug1) : BE0000694 Beta-2 adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0002396 Voltage-dependent calcium channel subunit alpha-2/delta-2 (-1) --------------------------------------------------- Drug1 : DB00489 Sotalol Drug2 : DB01210 Levobunolol Pharmacological target (-,-) : BE0000172 Beta-1 adrenergic receptor Pharmacological target (-,-) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) --------------------------------------------------- Drug1 : DB00489 Sotalol Drug2 : DB01214 Metipranolol Pharmacological target (-,-) : BE0000172 Beta-1 adrenergic receptor Pharmacological target (-,-) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) --------------------------------------------------- Drug1 : DB00490 Buspirone Drug2 : DB00502 Haloperidol Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000291 5-hydroxytryptamine receptor 1A (1) Non-common off-target(s) (drug2) : BE0000417 Glutamate receptor ionotropic, NMDA 2B (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00490 Buspirone Drug2 : DB00623 Fluphenazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000291 5-hydroxytryptamine receptor 1A (1) Non-common off-target(s) (drug2) : BE0000020 D(1A) dopamine receptor (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00490 Buspirone Drug2 : DB00850 Perphenazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000291 5-hydroxytryptamine receptor 1A (1) Non-common off-target(s) (drug2) : BE0000020 D(1A) dopamine receptor (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00490 Buspirone Drug2 : DB00933 Mesoridazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000291 5-hydroxytryptamine receptor 1A (1) Non-common off-target(s) (drug2) : BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB00490 Buspirone Drug2 : DB01063 Acetophenazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000291 5-hydroxytryptamine receptor 1A (1) Non-common off-target(s) (drug2) : BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00490 Buspirone Drug2 : DB01184 Domperidone Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000291 5-hydroxytryptamine receptor 1A (1) Non-common off-target(s) (drug2) : BE0000581 D(3) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00490 Buspirone Drug2 : DB01233 Metoclopramide Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000291 5-hydroxytryptamine receptor 1A (1) Non-common off-target(s) (drug2) : BE0000092 Muscarinic acetylcholine receptor M1 (1) BE0000311 5-hydroxytryptamine receptor 3A (1) BE0000084 5-hydroxytryptamine receptor 4 (1) --------------------------------------------------- Drug1 : DB00490 Buspirone Drug2 : DB01403 Methotrimeprazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000291 5-hydroxytryptamine receptor 1A (1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000145 D(1B) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00490 Buspirone Drug2 : DB01425 Alizapride Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000291 5-hydroxytryptamine receptor 1A (1) --------------------------------------------------- Drug1 : DB00490 Buspirone Drug2 : DB04842 Fluspirilene Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000291 5-hydroxytryptamine receptor 1A (1) Non-common off-target(s) (drug2) : BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000679 Voltage-dependent calcium channel gamma-1 subunit (-1) --------------------------------------------------- Drug1 : DB00490 Buspirone Drug2 : DB06288 Amisulpride Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000291 5-hydroxytryptamine receptor 1A (1) Non-common off-target(s) (drug2) : BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000581 D(3) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00490 Buspirone Drug2 : DB08810 Cinitapride Pharmacological target (+,+) : BE0000291 5-hydroxytryptamine receptor 1A Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000084 5-hydroxytryptamine receptor 4 (1) --------------------------------------------------- Drug1 : DB00490 Buspirone Drug2 : DB09018 Bromopride Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000291 5-hydroxytryptamine receptor 1A (1) --------------------------------------------------- Drug1 : DB00492 Fosinopril Drug2 : DB00519 Trandolapril Pharmacological target (-,-) : BE0000221 Angiotensin-converting enzyme --------------------------------------------------- Drug1 : DB00492 Fosinopril Drug2 : DB00542 Benazepril Pharmacological target (-,-) : BE0000221 Angiotensin-converting enzyme --------------------------------------------------- Drug1 : DB00492 Fosinopril Drug2 : DB00584 Enalapril Pharmacological target (-,-) : BE0000221 Angiotensin-converting enzyme --------------------------------------------------- Drug1 : DB00492 Fosinopril Drug2 : DB00691 Moexipril Pharmacological target (-,-) : BE0000221 Angiotensin-converting enzyme Non-common off-target(s) (drug2) : BE0000982 Angiotensin-converting enzyme 2 (-1) --------------------------------------------------- Drug1 : DB00492 Fosinopril Drug2 : DB00722 Lisinopril Pharmacological target (-,-) : BE0000221 Angiotensin-converting enzyme Non-common off-target(s) (drug2) : BE0000982 Angiotensin-converting enzyme 2 (-1) --------------------------------------------------- Drug1 : DB00492 Fosinopril Drug2 : DB00790 Perindopril Pharmacological target (-,-) : BE0000221 Angiotensin-converting enzyme --------------------------------------------------- Drug1 : DB00492 Fosinopril Drug2 : DB00881 Quinapril Pharmacological target (-,-) : BE0000221 Angiotensin-converting enzyme --------------------------------------------------- Drug1 : DB00492 Fosinopril Drug2 : DB01180 Rescinnamine Pharmacological target (-,-) : BE0000221 Angiotensin-converting enzyme --------------------------------------------------- Drug1 : DB00492 Fosinopril Drug2 : DB01197 Captopril Pharmacological target (-,-) : BE0000221 Angiotensin-converting enzyme Non-common off-target(s) (drug2) : BE0000642 72 kDa type IV collagenase (-1) BE0000058 Matrix metalloproteinase-9 (-1) --------------------------------------------------- Drug1 : DB00492 Fosinopril Drug2 : DB01340 Cilazapril Pharmacological target (-,-) : BE0000221 Angiotensin-converting enzyme --------------------------------------------------- Drug1 : DB00492 Fosinopril Drug2 : DB01348 Spirapril Pharmacological target (-,-) : BE0000221 Angiotensin-converting enzyme --------------------------------------------------- Drug1 : DB00496 Darifenacin Drug2 : DB00729 Diphemanil Methylsulfate Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00497 Oxycodone Drug2 : DB00836 Loperamide Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Pharmacological target (+,+) : BE0000632 Kappa-type opioid receptor Pharmacological target (+,+) : BE0000420 Delta-type opioid receptor Non-common off-target(s) (drug1) : BE0004899 Kappa-type opioid receptor 2b (1) Non-common off-target(s) (drug2) : BE0000356 Voltage-dependent P/Q-type calcium channel subunit alpha-1A (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00497 Oxycodone Drug2 : DB00956 Hydrocodone Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Pharmacological target (+,+) : BE0000420 Delta-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (1) BE0004899 Kappa-type opioid receptor 2b (1) --------------------------------------------------- Drug1 : DB00497 Oxycodone Drug2 : DB01439 3-Methylthiofentanyl Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Pharmacological target (+,+) : BE0000632 Kappa-type opioid receptor Pharmacological target (+,+) : BE0000420 Delta-type opioid receptor Non-common off-target(s) (drug1) : BE0004899 Kappa-type opioid receptor 2b (1) --------------------------------------------------- Drug1 : DB00497 Oxycodone Drug2 : DB01497 Etorphine Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Pharmacological target (+,+) : BE0000632 Kappa-type opioid receptor Pharmacological target (+,+) : BE0000420 Delta-type opioid receptor Non-common off-target(s) (drug1) : BE0004899 Kappa-type opioid receptor 2b (1) Non-common off-target(s) (drug2) : BE0002378 Nociceptin receptor (1) BE0001063 E3 ubiquitin-protein ligase TRIM13 (1) --------------------------------------------------- Drug1 : DB00497 Oxycodone Drug2 : DB01571 3-Methylfentanyl Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Pharmacological target (+,+) : BE0000632 Kappa-type opioid receptor Pharmacological target (+,+) : BE0000420 Delta-type opioid receptor Non-common off-target(s) (drug1) : BE0004899 Kappa-type opioid receptor 2b (1) --------------------------------------------------- Drug1 : DB00497 Oxycodone Drug2 : DB06738 Ketobemidone Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Pharmacological target (+,+) : BE0000632 Kappa-type opioid receptor Pharmacological target (+,+) : BE0000420 Delta-type opioid receptor Non-common off-target(s) (drug1) : BE0004899 Kappa-type opioid receptor 2b (1) Non-common off-target(s) (drug2) : BE0004956 NMDA receptor (-1) --------------------------------------------------- Drug1 : DB00498 Phenindione Drug2 : DB00682 Warfarin Pharmacological target (-,-) : BE0000713 Vitamin K epoxide reductase complex subunit 1 --------------------------------------------------- Drug1 : DB00498 Phenindione Drug2 : DB00946 Phenprocoumon Pharmacological target (-,-) : BE0000713 Vitamin K epoxide reductase complex subunit 1 --------------------------------------------------- Drug1 : DB00498 Phenindione Drug2 : DB01418 Acenocoumarol Pharmacological target (-,-) : BE0000713 Vitamin K epoxide reductase complex subunit 1 --------------------------------------------------- Drug1 : DB00499 Flutamide Drug2 : DB00665 Nilutamide Pharmacological target (-,-) : BE0000132 Androgen receptor Non-common off-target(s) (drug1) : BE0003721 Aryl hydrocarbon receptor (1) --------------------------------------------------- Drug1 : DB00499 Flutamide Drug2 : DB01128 Bicalutamide Pharmacological target (-,-) : BE0000132 Androgen receptor Non-common off-target(s) (drug1) : BE0003721 Aryl hydrocarbon receptor (1) --------------------------------------------------- Drug1 : DB00499 Flutamide Drug2 : DB04839 Cyproterone acetate Pharmacological target (-,-) : BE0000132 Androgen receptor Non-common off-target(s) (drug1) : BE0003721 Aryl hydrocarbon receptor (1) --------------------------------------------------- Drug1 : DB00499 Flutamide Drug2 : DB08899 Enzalutamide Pharmacological target (-,-) : BE0000132 Androgen receptor Non-common off-target(s) (drug1) : BE0003721 Aryl hydrocarbon receptor (1) --------------------------------------------------- Drug1 : DB00500 Tolmetin Drug2 : DB00533 Rofecoxib Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) --------------------------------------------------- Drug1 : DB00500 Tolmetin Drug2 : DB00580 Valdecoxib Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) --------------------------------------------------- Drug1 : DB00500 Tolmetin Drug2 : DB01050 Ibuprofen Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) Non-common off-target(s) (drug2) : BE0001088 Tissue-type plasminogen activator (-1) BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0001195 Cystic fibrosis transmembrane conductance regulator (-1) --------------------------------------------------- Drug1 : DB00500 Tolmetin Drug2 : DB01628 Etoricoxib Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) --------------------------------------------------- Drug1 : DB00500 Tolmetin Drug2 : DB04552 Niflumic Acid Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) Non-common off-target(s) (drug2) : BE0003997 Phospholipase A2 (-1) BE0002376 Chloride channel protein ClC-Ka (1) --------------------------------------------------- Drug1 : DB00500 Tolmetin Drug2 : DB04743 Nimesulide Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) --------------------------------------------------- Drug1 : DB00501 Cimetidine Drug2 : DB00585 Nizatidine Pharmacological target (-,-) : BE0000112 Histamine H2 receptor --------------------------------------------------- Drug1 : DB00501 Cimetidine Drug2 : DB00751 Epinastine Pharmacological target (-,-) : BE0000112 Histamine H2 receptor Non-common off-target(s) (drug2) : BE0000442 Histamine H1 receptor (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB00501 Cimetidine Drug2 : DB00863 Ranitidine Pharmacological target (-,-) : BE0000112 Histamine H2 receptor --------------------------------------------------- Drug1 : DB00501 Cimetidine Drug2 : DB00927 Famotidine Pharmacological target (-,-) : BE0000112 Histamine H2 receptor --------------------------------------------------- Drug1 : DB00501 Cimetidine Drug2 : DB00940 Methantheline Pharmacological target (-,-) : BE0000112 Histamine H2 receptor Non-common off-target(s) (drug2) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) --------------------------------------------------- Drug1 : DB00501 Cimetidine Drug2 : DB08805 Metiamide Pharmacological target (-,-) : BE0000112 Histamine H2 receptor --------------------------------------------------- Drug1 : DB00501 Cimetidine Drug2 : DB08806 Roxatidine acetate Pharmacological target (-,-) : BE0000112 Histamine H2 receptor --------------------------------------------------- Drug1 : DB00502 Haloperidol Drug2 : DB00933 Mesoridazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000417 Glutamate receptor ionotropic, NMDA 2B (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB00502 Haloperidol Drug2 : DB01233 Metoclopramide Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000417 Glutamate receptor ionotropic, NMDA 2B (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000092 Muscarinic acetylcholine receptor M1 (1) BE0000311 5-hydroxytryptamine receptor 3A (1) BE0000084 5-hydroxytryptamine receptor 4 (1) --------------------------------------------------- Drug1 : DB00502 Haloperidol Drug2 : DB01425 Alizapride Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000417 Glutamate receptor ionotropic, NMDA 2B (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00502 Haloperidol Drug2 : DB01618 Molindone Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000417 Glutamate receptor ionotropic, NMDA 2B (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB00502 Haloperidol Drug2 : DB04842 Fluspirilene Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000417 Glutamate receptor ionotropic, NMDA 2B (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000679 Voltage-dependent calcium channel gamma-1 subunit (-1) --------------------------------------------------- Drug1 : DB00502 Haloperidol Drug2 : DB08815 Lurasidone Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000417 Glutamate receptor ionotropic, NMDA 2B (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000342 Alpha-2C adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00502 Haloperidol Drug2 : DB09018 Bromopride Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000417 Glutamate receptor ionotropic, NMDA 2B (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00504 Levallorphan Drug2 : DB00708 Sufentanil Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug2) : BE0000420 Delta-type opioid receptor (1) --------------------------------------------------- Drug1 : DB00504 Levallorphan Drug2 : DB00802 Alfentanil Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor --------------------------------------------------- Drug1 : DB00504 Levallorphan Drug2 : DB00813 Fentanyl Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug2) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) --------------------------------------------------- Drug1 : DB00504 Levallorphan Drug2 : DB00854 Levorphanol Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug2) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) --------------------------------------------------- Drug1 : DB00504 Levallorphan Drug2 : DB00899 Remifentanil Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug2) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) --------------------------------------------------- Drug1 : DB00504 Levallorphan Drug2 : DB00913 Anileridine Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor --------------------------------------------------- Drug1 : DB00504 Levallorphan Drug2 : DB00921 Buprenorphine Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug2) : BE0000632 Kappa-type opioid receptor (-1) BE0000420 Delta-type opioid receptor (-1) --------------------------------------------------- Drug1 : DB00504 Levallorphan Drug2 : DB00956 Hydrocodone Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug2) : BE0000420 Delta-type opioid receptor (1) --------------------------------------------------- Drug1 : DB00504 Levallorphan Drug2 : DB01081 Diphenoxylate Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug2) : BE0000420 Delta-type opioid receptor (1) --------------------------------------------------- Drug1 : DB00504 Levallorphan Drug2 : DB01192 Oxymorphone Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug2) : BE0000420 Delta-type opioid receptor (-1) --------------------------------------------------- Drug1 : DB00504 Levallorphan Drug2 : DB01209 Dezocine Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug2) : BE0000632 Kappa-type opioid receptor (-1) --------------------------------------------------- Drug1 : DB00504 Levallorphan Drug2 : DB01227 Levomethadyl Acetate Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug2) : BE0003585 Neuronal acetylcholine receptor subunit alpha-3 (-1) --------------------------------------------------- Drug1 : DB00504 Levallorphan Drug2 : DB01433 Methadyl Acetate Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor --------------------------------------------------- Drug1 : DB00504 Levallorphan Drug2 : DB01444 Dimethylthiambutene Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug2) : BE0000420 Delta-type opioid receptor (1) --------------------------------------------------- Drug1 : DB00504 Levallorphan Drug2 : DB01452 Heroin Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug2) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) --------------------------------------------------- Drug1 : DB00504 Levallorphan Drug2 : DB01466 Ethylmorphine Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor --------------------------------------------------- Drug1 : DB00504 Levallorphan Drug2 : DB01535 Carfentanil Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug2) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) --------------------------------------------------- Drug1 : DB00504 Levallorphan Drug2 : DB01565 Dihydromorphine Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug2) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) BE0000947 Pro-opiomelanocortin (1) BE0001063 E3 ubiquitin-protein ligase TRIM13 (1) --------------------------------------------------- Drug1 : DB00504 Levallorphan Drug2 : DB06204 Tapentadol Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB00505 Tridihexethyl Drug2 : DB00517 Anisotropine Methylbromide Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 --------------------------------------------------- Drug1 : DB00505 Tridihexethyl Drug2 : DB00572 Atropine Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug2) : BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00505 Tridihexethyl Drug2 : DB00725 Homatropine Methylbromide Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug2) : BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00505 Tridihexethyl Drug2 : DB00767 Benzquinamide Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug2) : BE0000442 Histamine H1 receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00505 Tridihexethyl Drug2 : DB00785 Cryptenamine Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug2) : BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00505 Tridihexethyl Drug2 : DB01036 Tolterodine Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug2) : BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00505 Tridihexethyl Drug2 : DB01062 Oxybutynin Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 --------------------------------------------------- Drug1 : DB00505 Tridihexethyl Drug2 : DB01148 Flavoxate Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) --------------------------------------------------- Drug1 : DB00505 Tridihexethyl Drug2 : DB01231 Diphenidol Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 --------------------------------------------------- Drug1 : DB00505 Tridihexethyl Drug2 : DB04843 Mepenzolate Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00505 Tridihexethyl Drug2 : DB08897 Aclidinium Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug2) : BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00509 Dextrothyroxine Drug2 : DB01583 Liotrix Pharmacological target (+,+) : BE0000687 Thyroid hormone receptor alpha Pharmacological target (+,+) : BE0000315 Thyroid hormone receptor beta --------------------------------------------------- Drug1 : DB00511 Acetyldigitoxin Drug2 : DB00903 Ethacrynic acid Pharmacological target (-,-) : BE0000732 Sodium/potassium-transporting ATPase subunit alpha-1 Non-common off-target(s) (drug2) : BE0000502 Solute carrier family 12 member 1 (-1) --------------------------------------------------- Drug1 : DB00511 Acetyldigitoxin Drug2 : DB01021 Trichlormethiazide Pharmacological target (-,-) : BE0000732 Sodium/potassium-transporting ATPase subunit alpha-1 Non-common off-target(s) (drug2) : BE0000502 Solute carrier family 12 member 1 (-1) BE0000267 Carbonic anhydrase 1 (-1) BE0000322 Carbonic anhydrase 2 (-1) BE0000535 Carbonic anhydrase 4 (-1) --------------------------------------------------- Drug1 : DB00511 Acetyldigitoxin Drug2 : DB01078 Deslanoside Pharmacological target (-,-) : BE0000732 Sodium/potassium-transporting ATPase subunit alpha-1 --------------------------------------------------- Drug1 : DB00511 Acetyldigitoxin Drug2 : DB01092 Ouabain Pharmacological target (-,-) : BE0000732 Sodium/potassium-transporting ATPase subunit alpha-1 --------------------------------------------------- Drug1 : DB00511 Acetyldigitoxin Drug2 : DB01158 Bretylium Pharmacological target (-,-) : BE0000732 Sodium/potassium-transporting ATPase subunit alpha-1 --------------------------------------------------- Drug1 : DB00511 Acetyldigitoxin Drug2 : DB01396 Digitoxin Pharmacological target (-,-) : BE0000732 Sodium/potassium-transporting ATPase subunit alpha-1 --------------------------------------------------- Drug1 : DB00517 Anisotropine Methylbromide Drug2 : DB00572 Atropine Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug2) : BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00517 Anisotropine Methylbromide Drug2 : DB00725 Homatropine Methylbromide Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug2) : BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00517 Anisotropine Methylbromide Drug2 : DB00767 Benzquinamide Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug2) : BE0000442 Histamine H1 receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00517 Anisotropine Methylbromide Drug2 : DB00785 Cryptenamine Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug2) : BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00517 Anisotropine Methylbromide Drug2 : DB01036 Tolterodine Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug2) : BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00517 Anisotropine Methylbromide Drug2 : DB01062 Oxybutynin Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 --------------------------------------------------- Drug1 : DB00517 Anisotropine Methylbromide Drug2 : DB01148 Flavoxate Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) --------------------------------------------------- Drug1 : DB00517 Anisotropine Methylbromide Drug2 : DB01231 Diphenidol Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 --------------------------------------------------- Drug1 : DB00517 Anisotropine Methylbromide Drug2 : DB04843 Mepenzolate Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00517 Anisotropine Methylbromide Drug2 : DB08897 Aclidinium Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug2) : BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00519 Trandolapril Drug2 : DB00542 Benazepril Pharmacological target (-,-) : BE0000221 Angiotensin-converting enzyme --------------------------------------------------- Drug1 : DB00519 Trandolapril Drug2 : DB00584 Enalapril Pharmacological target (-,-) : BE0000221 Angiotensin-converting enzyme --------------------------------------------------- Drug1 : DB00519 Trandolapril Drug2 : DB00691 Moexipril Pharmacological target (-,-) : BE0000221 Angiotensin-converting enzyme Non-common off-target(s) (drug2) : BE0000982 Angiotensin-converting enzyme 2 (-1) --------------------------------------------------- Drug1 : DB00519 Trandolapril Drug2 : DB00722 Lisinopril Pharmacological target (-,-) : BE0000221 Angiotensin-converting enzyme Non-common off-target(s) (drug2) : BE0000982 Angiotensin-converting enzyme 2 (-1) --------------------------------------------------- Drug1 : DB00519 Trandolapril Drug2 : DB00790 Perindopril Pharmacological target (-,-) : BE0000221 Angiotensin-converting enzyme --------------------------------------------------- Drug1 : DB00519 Trandolapril Drug2 : DB00881 Quinapril Pharmacological target (-,-) : BE0000221 Angiotensin-converting enzyme --------------------------------------------------- Drug1 : DB00519 Trandolapril Drug2 : DB01180 Rescinnamine Pharmacological target (-,-) : BE0000221 Angiotensin-converting enzyme --------------------------------------------------- Drug1 : DB00519 Trandolapril Drug2 : DB01197 Captopril Pharmacological target (-,-) : BE0000221 Angiotensin-converting enzyme Non-common off-target(s) (drug2) : BE0000642 72 kDa type IV collagenase (-1) BE0000058 Matrix metalloproteinase-9 (-1) --------------------------------------------------- Drug1 : DB00519 Trandolapril Drug2 : DB01340 Cilazapril Pharmacological target (-,-) : BE0000221 Angiotensin-converting enzyme --------------------------------------------------- Drug1 : DB00519 Trandolapril Drug2 : DB01348 Spirapril Pharmacological target (-,-) : BE0000221 Angiotensin-converting enzyme --------------------------------------------------- Drug1 : DB00523 Alitretinoin Drug2 : DB00755 Tretinoin Pharmacological target (+,+) : BE0000144 Retinoic acid receptor gamma Pharmacological target (+,+) : BE0000707 Retinoic acid receptor RXR-gamma Pharmacological target (+,+) : BE0000078 Retinoic acid receptor RXR-beta Non-common off-target(s) (drug1) : BE0000206 Retinoic acid receptor beta (1) BE0000663 Retinoic acid receptor alpha (1) BE0000412 Retinoic acid receptor RXR-alpha (1) Non-common off-target(s) (drug2) : BE0000653 Retinoic acid receptor responder protein 1 (1) --------------------------------------------------- Drug1 : DB00523 Alitretinoin Drug2 : DB00799 Tazarotene Pharmacological target (+,+) : BE0000144 Retinoic acid receptor gamma Pharmacological target (+,+) : BE0000206 Retinoic acid receptor beta Pharmacological target (+,+) : BE0000078 Retinoic acid receptor RXR-beta Pharmacological target (+,+) : BE0000663 Retinoic acid receptor alpha Non-common off-target(s) (drug1) : BE0000707 Retinoic acid receptor RXR-gamma (1) BE0000412 Retinoic acid receptor RXR-alpha (1) --------------------------------------------------- Drug1 : DB00523 Alitretinoin Drug2 : DB00926 Etretinate Pharmacological target (+,+) : BE0000144 Retinoic acid receptor gamma Pharmacological target (+,+) : BE0000206 Retinoic acid receptor beta Pharmacological target (+,+) : BE0000707 Retinoic acid receptor RXR-gamma Pharmacological target (+,+) : BE0000078 Retinoic acid receptor RXR-beta Pharmacological target (+,+) : BE0000663 Retinoic acid receptor alpha Pharmacological target (+,+) : BE0000412 Retinoic acid receptor RXR-alpha --------------------------------------------------- Drug1 : DB00524 Metolazone Drug2 : DB00562 Benzthiazide Pharmacological target (-,-) : BE0000419 Solute carrier family 12 member 3 Non-common off-target(s) (drug2) : BE0000267 Carbonic anhydrase 1 (-1) BE0000322 Carbonic anhydrase 2 (-1) BE0000535 Carbonic anhydrase 4 (-1) BE0002437 Carbonic anhydrase 9 (-1) BE0001653 Carbonic anhydrase 12 (-1) --------------------------------------------------- Drug1 : DB00524 Metolazone Drug2 : DB00999 Hydrochlorothiazide Pharmacological target (-,-) : BE0000419 Solute carrier family 12 member 3 Non-common off-target(s) (drug2) : BE0000267 Carbonic anhydrase 1 (-1) BE0000322 Carbonic anhydrase 2 (-1) BE0000535 Carbonic anhydrase 4 (-1) BE0002437 Carbonic anhydrase 9 (-1) BE0001653 Carbonic anhydrase 12 (-1) --------------------------------------------------- Drug1 : DB00524 Metolazone Drug2 : DB01324 Polythiazide Pharmacological target (-,-) : BE0000419 Solute carrier family 12 member 3 --------------------------------------------------- Drug1 : DB00527 Cinchocaine Drug2 : DB00532 Mephenytoin Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0000177 Sodium channel protein type 10 subunit alpha (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00527 Cinchocaine Drug2 : DB00564 Carbamazepine Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0000177 Sodium channel protein type 10 subunit alpha (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00527 Cinchocaine Drug2 : DB00645 Dyclonine Pharmacological target (-,-) : BE0000177 Sodium channel protein type 10 subunit alpha Non-common off-target(s) (drug1) : BE0000197 Sodium channel protein type 5 subunit alpha (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00527 Cinchocaine Drug2 : DB00680 Moricizine Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0000177 Sodium channel protein type 10 subunit alpha (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00527 Cinchocaine Drug2 : DB00740 Riluzole Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0000177 Sodium channel protein type 10 subunit alpha (-1) BE0000418 Calmodulin (-1) Non-common off-target(s) (drug2) : BE0000030 Cystine/glutamate transporter (1) --------------------------------------------------- Drug1 : DB00527 Cinchocaine Drug2 : DB00750 Prilocaine Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0000177 Sodium channel protein type 10 subunit alpha (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00527 Cinchocaine Drug2 : DB00754 Ethotoin Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0000177 Sodium channel protein type 10 subunit alpha (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00527 Cinchocaine Drug2 : DB00776 Oxcarbazepine Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0000177 Sodium channel protein type 10 subunit alpha (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00527 Cinchocaine Drug2 : DB00807 Proparacaine Pharmacological target (-,-) : BE0000177 Sodium channel protein type 10 subunit alpha Non-common off-target(s) (drug1) : BE0000197 Sodium channel protein type 5 subunit alpha (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00527 Cinchocaine Drug2 : DB00892 Oxybuprocaine Pharmacological target (-,-) : BE0000177 Sodium channel protein type 10 subunit alpha Non-common off-target(s) (drug1) : BE0000197 Sodium channel protein type 5 subunit alpha (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00527 Cinchocaine Drug2 : DB00908 Quinidine Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0000177 Sodium channel protein type 10 subunit alpha (-1) BE0000418 Calmodulin (-1) Non-common off-target(s) (drug2) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000154 Potassium channel subfamily K member 1 (-1) BE0000680 Potassium channel subfamily K member 6 (-1) --------------------------------------------------- Drug1 : DB00527 Cinchocaine Drug2 : DB00961 Mepivacaine Pharmacological target (-,-) : BE0000177 Sodium channel protein type 10 subunit alpha Non-common off-target(s) (drug1) : BE0000197 Sodium channel protein type 5 subunit alpha (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00527 Cinchocaine Drug2 : DB01002 Levobupivacaine Pharmacological target (-,-) : BE0000177 Sodium channel protein type 10 subunit alpha Non-common off-target(s) (drug1) : BE0000197 Sodium channel protein type 5 subunit alpha (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00527 Cinchocaine Drug2 : DB01056 Tocainide Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0000177 Sodium channel protein type 10 subunit alpha (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00527 Cinchocaine Drug2 : DB01086 Benzocaine Pharmacological target (-,-) : BE0000177 Sodium channel protein type 10 subunit alpha Non-common off-target(s) (drug1) : BE0000197 Sodium channel protein type 5 subunit alpha (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00527 Cinchocaine Drug2 : DB01161 Chloroprocaine Pharmacological target (-,-) : BE0000177 Sodium channel protein type 10 subunit alpha Non-common off-target(s) (drug1) : BE0000197 Sodium channel protein type 5 subunit alpha (-1) BE0000418 Calmodulin (-1) Non-common off-target(s) (drug2) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000411 Neuronal acetylcholine receptor subunit alpha-10 (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) --------------------------------------------------- Drug1 : DB00527 Cinchocaine Drug2 : DB01182 Propafenone Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0000177 Sodium channel protein type 10 subunit alpha (-1) BE0000418 Calmodulin (-1) Non-common off-target(s) (drug2) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) --------------------------------------------------- Drug1 : DB00527 Cinchocaine Drug2 : DB01195 Flecainide Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0000177 Sodium channel protein type 10 subunit alpha (-1) BE0000418 Calmodulin (-1) Non-common off-target(s) (drug2) : BE0002083 Sodium channel protein type 4 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00527 Cinchocaine Drug2 : DB01228 Encainide Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0000177 Sodium channel protein type 10 subunit alpha (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00527 Cinchocaine Drug2 : DB01320 Fosphenytoin Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0000177 Sodium channel protein type 10 subunit alpha (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00527 Cinchocaine Drug2 : DB01426 Ajmaline Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0000177 Sodium channel protein type 10 subunit alpha (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00530 Erlotinib Drug2 : DB01259 Lapatinib Pharmacological target (-,-) : BE0000767 Epidermal growth factor receptor Non-common off-target(s) (drug1) : BE0000956 Nuclear receptor subfamily 1 group I member 2 (1) Non-common off-target(s) (drug2) : BE0000511 Receptor tyrosine-protein kinase erbB-2 (-1) --------------------------------------------------- Drug1 : DB00530 Erlotinib Drug2 : DB01269 Panitumumab Pharmacological target (-,-) : BE0000767 Epidermal growth factor receptor Non-common off-target(s) (drug1) : BE0000956 Nuclear receptor subfamily 1 group I member 2 (1) --------------------------------------------------- Drug1 : DB00532 Mephenytoin Drug2 : DB00564 Carbamazepine Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha --------------------------------------------------- Drug1 : DB00532 Mephenytoin Drug2 : DB00680 Moricizine Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha --------------------------------------------------- Drug1 : DB00532 Mephenytoin Drug2 : DB00740 Riluzole Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug2) : BE0000030 Cystine/glutamate transporter (1) --------------------------------------------------- Drug1 : DB00532 Mephenytoin Drug2 : DB00750 Prilocaine Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha --------------------------------------------------- Drug1 : DB00532 Mephenytoin Drug2 : DB00754 Ethotoin Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha --------------------------------------------------- Drug1 : DB00532 Mephenytoin Drug2 : DB00776 Oxcarbazepine Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha --------------------------------------------------- Drug1 : DB00532 Mephenytoin Drug2 : DB00908 Quinidine Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug2) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000154 Potassium channel subfamily K member 1 (-1) BE0000680 Potassium channel subfamily K member 6 (-1) --------------------------------------------------- Drug1 : DB00532 Mephenytoin Drug2 : DB01056 Tocainide Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha --------------------------------------------------- Drug1 : DB00532 Mephenytoin Drug2 : DB01182 Propafenone Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug2) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) --------------------------------------------------- Drug1 : DB00532 Mephenytoin Drug2 : DB01195 Flecainide Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug2) : BE0002083 Sodium channel protein type 4 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00532 Mephenytoin Drug2 : DB01228 Encainide Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha --------------------------------------------------- Drug1 : DB00532 Mephenytoin Drug2 : DB01320 Fosphenytoin Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha --------------------------------------------------- Drug1 : DB00532 Mephenytoin Drug2 : DB01426 Ajmaline Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha --------------------------------------------------- Drug1 : DB00532 Mephenytoin Drug2 : DB01429 Aprindine Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug2) : BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00533 Rofecoxib Drug2 : DB00554 Piroxicam Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug2) : BE0000017 Prostaglandin G/H synthase 1 (-1) --------------------------------------------------- Drug1 : DB00533 Rofecoxib Drug2 : DB00573 Fenoprofen Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug2) : BE0000017 Prostaglandin G/H synthase 1 (-1) --------------------------------------------------- Drug1 : DB00533 Rofecoxib Drug2 : DB00580 Valdecoxib Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 --------------------------------------------------- Drug1 : DB00533 Rofecoxib Drug2 : DB00605 Sulindac Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug2) : BE0000017 Prostaglandin G/H synthase 1 (-1) BE0000747 Aldose reductase (-1) BE0001007 Peroxisome proliferator-activated receptor delta (-1) BE0003561 Prostaglandin D2 receptor 2 (-1) BE0001062 Mitogen-activated protein kinase 3 (-1) --------------------------------------------------- Drug1 : DB00533 Rofecoxib Drug2 : DB00712 Flurbiprofen Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug2) : BE0000017 Prostaglandin G/H synthase 1 (-1) --------------------------------------------------- Drug1 : DB00533 Rofecoxib Drug2 : DB00749 Etodolac Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug2) : BE0000017 Prostaglandin G/H synthase 1 (-1) --------------------------------------------------- Drug1 : DB00533 Rofecoxib Drug2 : DB00784 Mefenamic acid Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug2) : BE0000017 Prostaglandin G/H synthase 1 (-1) --------------------------------------------------- Drug1 : DB00533 Rofecoxib Drug2 : DB00788 Naproxen Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug2) : BE0000017 Prostaglandin G/H synthase 1 (-1) --------------------------------------------------- Drug1 : DB00533 Rofecoxib Drug2 : DB00814 Meloxicam Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug2) : BE0000017 Prostaglandin G/H synthase 1 (-1) --------------------------------------------------- Drug1 : DB00533 Rofecoxib Drug2 : DB00821 Carprofen Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug2) : BE0000017 Prostaglandin G/H synthase 1 (-1) --------------------------------------------------- Drug1 : DB00533 Rofecoxib Drug2 : DB00861 Diflunisal Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug2) : BE0000017 Prostaglandin G/H synthase 1 (-1) --------------------------------------------------- Drug1 : DB00533 Rofecoxib Drug2 : DB00870 Suprofen Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug2) : BE0000017 Prostaglandin G/H synthase 1 (-1) --------------------------------------------------- Drug1 : DB00533 Rofecoxib Drug2 : DB00936 Salicylic acid Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug2) : BE0000017 Prostaglandin G/H synthase 1 (-1) BE0000126 Aldo-keto reductase family 1 member C1 (-1) --------------------------------------------------- Drug1 : DB00533 Rofecoxib Drug2 : DB00945 Acetylsalicylic acid Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug2) : BE0000017 Prostaglandin G/H synthase 1 (-1) BE0000126 Aldo-keto reductase family 1 member C1 (-1) BE0004907 5'-AMP-activated protein kinase (1) BE0004903 Nuclear factor NF-kappa-B (-1) --------------------------------------------------- Drug1 : DB00533 Rofecoxib Drug2 : DB00963 Bromfenac Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug2) : BE0000017 Prostaglandin G/H synthase 1 (-1) --------------------------------------------------- Drug1 : DB00533 Rofecoxib Drug2 : DB00991 Oxaprozin Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug2) : BE0000017 Prostaglandin G/H synthase 1 (-1) --------------------------------------------------- Drug1 : DB00533 Rofecoxib Drug2 : DB01009 Ketoprofen Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug2) : BE0000017 Prostaglandin G/H synthase 1 (-1) --------------------------------------------------- Drug1 : DB00533 Rofecoxib Drug2 : DB01050 Ibuprofen Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug2) : BE0001088 Tissue-type plasminogen activator (-1) BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0001195 Cystic fibrosis transmembrane conductance regulator (-1) --------------------------------------------------- Drug1 : DB00533 Rofecoxib Drug2 : DB01283 Lumiracoxib Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug2) : BE0000017 Prostaglandin G/H synthase 1 (-1) --------------------------------------------------- Drug1 : DB00533 Rofecoxib Drug2 : DB01397 Magnesium salicylate Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug2) : BE0000017 Prostaglandin G/H synthase 1 (-1) --------------------------------------------------- Drug1 : DB00533 Rofecoxib Drug2 : DB01398 Salicylate-sodium Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug2) : BE0000017 Prostaglandin G/H synthase 1 (-1) --------------------------------------------------- Drug1 : DB00533 Rofecoxib Drug2 : DB01399 Salsalate Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug2) : BE0000017 Prostaglandin G/H synthase 1 (-1) --------------------------------------------------- Drug1 : DB00533 Rofecoxib Drug2 : DB01600 Tiaprofenic acid Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug2) : BE0000017 Prostaglandin G/H synthase 1 (-1) --------------------------------------------------- Drug1 : DB00533 Rofecoxib Drug2 : DB01628 Etoricoxib Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 --------------------------------------------------- Drug1 : DB00533 Rofecoxib Drug2 : DB04552 Niflumic Acid Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug2) : BE0003997 Phospholipase A2 (-1) BE0002376 Chloride channel protein ClC-Ka (1) --------------------------------------------------- Drug1 : DB00533 Rofecoxib Drug2 : DB04743 Nimesulide Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 --------------------------------------------------- Drug1 : DB00533 Rofecoxib Drug2 : DB06725 Lornoxicam Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug2) : BE0000017 Prostaglandin G/H synthase 1 (-1) --------------------------------------------------- Drug1 : DB00540 Nortriptyline Drug2 : DB00579 Mazindol Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0004872 Beta adrenergic receptor (-1) BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0004864 Alpha-2 adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB00540 Nortriptyline Drug2 : DB01105 Sibutramine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0004872 Beta adrenergic receptor (-1) BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0004864 Alpha-2 adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB00540 Nortriptyline Drug2 : DB04896 Milnacipran Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0004872 Beta adrenergic receptor (-1) BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0004864 Alpha-2 adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) Non-common off-target(s) (drug2) : BE0004956 NMDA receptor (-1) --------------------------------------------------- Drug1 : DB00540 Nortriptyline Drug2 : DB06700 Desvenlafaxine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0004872 Beta adrenergic receptor (-1) BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0004864 Alpha-2 adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00540 Nortriptyline Drug2 : DB08918 Levomilnacipran Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0004872 Beta adrenergic receptor (-1) BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0004864 Alpha-2 adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00541 Vincristine Drug2 : DB01394 Colchicine Pharmacological target (-,-) : BE0000143 Tubulin beta chain Non-common off-target(s) (drug1) : BE0001391 Tubulin alpha-4A chain (-1) Non-common off-target(s) (drug2) : BE0000026 Tubulin beta-1 chain (-1) --------------------------------------------------- Drug1 : DB00542 Benazepril Drug2 : DB00584 Enalapril Pharmacological target (-,-) : BE0000221 Angiotensin-converting enzyme --------------------------------------------------- Drug1 : DB00542 Benazepril Drug2 : DB00691 Moexipril Pharmacological target (-,-) : BE0000221 Angiotensin-converting enzyme Non-common off-target(s) (drug2) : BE0000982 Angiotensin-converting enzyme 2 (-1) --------------------------------------------------- Drug1 : DB00542 Benazepril Drug2 : DB00722 Lisinopril Pharmacological target (-,-) : BE0000221 Angiotensin-converting enzyme Non-common off-target(s) (drug2) : BE0000982 Angiotensin-converting enzyme 2 (-1) --------------------------------------------------- Drug1 : DB00542 Benazepril Drug2 : DB00790 Perindopril Pharmacological target (-,-) : BE0000221 Angiotensin-converting enzyme --------------------------------------------------- Drug1 : DB00542 Benazepril Drug2 : DB00881 Quinapril Pharmacological target (-,-) : BE0000221 Angiotensin-converting enzyme --------------------------------------------------- Drug1 : DB00542 Benazepril Drug2 : DB01180 Rescinnamine Pharmacological target (-,-) : BE0000221 Angiotensin-converting enzyme --------------------------------------------------- Drug1 : DB00542 Benazepril Drug2 : DB01197 Captopril Pharmacological target (-,-) : BE0000221 Angiotensin-converting enzyme Non-common off-target(s) (drug2) : BE0000642 72 kDa type IV collagenase (-1) BE0000058 Matrix metalloproteinase-9 (-1) --------------------------------------------------- Drug1 : DB00542 Benazepril Drug2 : DB01340 Cilazapril Pharmacological target (-,-) : BE0000221 Angiotensin-converting enzyme --------------------------------------------------- Drug1 : DB00542 Benazepril Drug2 : DB01348 Spirapril Pharmacological target (-,-) : BE0000221 Angiotensin-converting enzyme --------------------------------------------------- Drug1 : DB00543 Amoxapine Drug2 : DB01104 Sertraline Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug1) : BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000756 D(2) dopamine receptor (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000797 5-hydroxytryptamine receptor 1B (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0004864 Alpha-2 adrenergic receptor (-1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0004863 Alpha-1 adrenergic receptor (-1) BE0004890 Muscarinic acetylcholine receptor (-1) Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB00545 Pyridostigmine Drug2 : DB00677 Isoflurophate Pharmacological target (-,-) : BE0000426 Acetylcholinesterase Pharmacological target (-,-) : BE0002180 Cholinesterase --------------------------------------------------- Drug1 : DB00545 Pyridostigmine Drug2 : DB00772 Malathion Pharmacological target (-,-) : BE0002180 Cholinesterase Non-common off-target(s) (drug1) : BE0000426 Acetylcholinesterase (-1) --------------------------------------------------- Drug1 : DB00545 Pyridostigmine Drug2 : DB00843 Donepezil Pharmacological target (-,-) : BE0000426 Acetylcholinesterase Non-common off-target(s) (drug1) : BE0002180 Cholinesterase (-1) --------------------------------------------------- Drug1 : DB00545 Pyridostigmine Drug2 : DB00941 Hexafluronium Pharmacological target (-,-) : BE0002180 Cholinesterase Non-common off-target(s) (drug1) : BE0000426 Acetylcholinesterase (-1) --------------------------------------------------- Drug1 : DB00545 Pyridostigmine Drug2 : DB00981 Physostigmine Pharmacological target (-,-) : BE0000426 Acetylcholinesterase Non-common off-target(s) (drug1) : BE0002180 Cholinesterase (-1) --------------------------------------------------- Drug1 : DB00545 Pyridostigmine Drug2 : DB00989 Rivastigmine Pharmacological target (-,-) : BE0000426 Acetylcholinesterase Pharmacological target (-,-) : BE0002180 Cholinesterase --------------------------------------------------- Drug1 : DB00545 Pyridostigmine Drug2 : DB01010 Edrophonium Pharmacological target (-,-) : BE0000426 Acetylcholinesterase Pharmacological target (-,-) : BE0002180 Cholinesterase --------------------------------------------------- Drug1 : DB00545 Pyridostigmine Drug2 : DB01057 Echothiophate Pharmacological target (-,-) : BE0002180 Cholinesterase Non-common off-target(s) (drug1) : BE0000426 Acetylcholinesterase (-1) --------------------------------------------------- Drug1 : DB00545 Pyridostigmine Drug2 : DB01122 Ambenonium Pharmacological target (-,-) : BE0000426 Acetylcholinesterase Non-common off-target(s) (drug1) : BE0002180 Cholinesterase (-1) --------------------------------------------------- Drug1 : DB00545 Pyridostigmine Drug2 : DB01400 Neostigmine Pharmacological target (-,-) : BE0000426 Acetylcholinesterase Non-common off-target(s) (drug1) : BE0002180 Cholinesterase (-1) --------------------------------------------------- Drug1 : DB00545 Pyridostigmine Drug2 : DB08996 Dimetacrine Pharmacological target (-,-) : BE0000426 Acetylcholinesterase Non-common off-target(s) (drug1) : BE0002180 Cholinesterase (-1) --------------------------------------------------- Drug1 : DB00546 Adinazolam Drug2 : DB00683 Midazolam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Pharmacological target (+,+) : BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Pharmacological target (+,+) : BE0003596 Gamma-aminobutyric acid receptor subunit pi Pharmacological target (+,+) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Pharmacological target (+,+) : BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 Pharmacological target (+,+) : BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 Non-common off-target(s) (drug2) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00546 Adinazolam Drug2 : DB00690 Flurazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Pharmacological target (+,+) : BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Pharmacological target (+,+) : BE0003596 Gamma-aminobutyric acid receptor subunit pi Pharmacological target (+,+) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Pharmacological target (+,+) : BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 Pharmacological target (+,+) : BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 Non-common off-target(s) (drug2) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00546 Adinazolam Drug2 : DB00801 Halazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Pharmacological target (+,+) : BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Pharmacological target (+,+) : BE0003596 Gamma-aminobutyric acid receptor subunit pi Pharmacological target (+,+) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Pharmacological target (+,+) : BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 Pharmacological target (+,+) : BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) --------------------------------------------------- Drug1 : DB00546 Adinazolam Drug2 : DB00829 Diazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Pharmacological target (+,+) : BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Pharmacological target (+,+) : BE0003596 Gamma-aminobutyric acid receptor subunit pi Pharmacological target (+,+) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Pharmacological target (+,+) : BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 Pharmacological target (+,+) : BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) BE0000736 Translocator protein (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00546 Adinazolam Drug2 : DB00842 Oxazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Pharmacological target (+,+) : BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Pharmacological target (+,+) : BE0003596 Gamma-aminobutyric acid receptor subunit pi Pharmacological target (+,+) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Pharmacological target (+,+) : BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 Pharmacological target (+,+) : BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00546 Adinazolam Drug2 : DB00897 Triazolam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Pharmacological target (+,+) : BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Pharmacological target (+,+) : BE0003596 Gamma-aminobutyric acid receptor subunit pi Pharmacological target (+,+) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Pharmacological target (+,+) : BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 Pharmacological target (+,+) : BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00546 Adinazolam Drug2 : DB01215 Estazolam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Pharmacological target (+,+) : BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Pharmacological target (+,+) : BE0003596 Gamma-aminobutyric acid receptor subunit pi Pharmacological target (+,+) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Pharmacological target (+,+) : BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 Pharmacological target (+,+) : BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) --------------------------------------------------- Drug1 : DB00546 Adinazolam Drug2 : DB01558 Bromazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Pharmacological target (+,+) : BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Pharmacological target (+,+) : BE0003596 Gamma-aminobutyric acid receptor subunit pi Pharmacological target (+,+) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Pharmacological target (+,+) : BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 Pharmacological target (+,+) : BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 Non-common off-target(s) (drug2) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00546 Adinazolam Drug2 : DB01559 Clotiazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Pharmacological target (+,+) : BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Pharmacological target (+,+) : BE0003596 Gamma-aminobutyric acid receptor subunit pi Pharmacological target (+,+) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Pharmacological target (+,+) : BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 Pharmacological target (+,+) : BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 --------------------------------------------------- Drug1 : DB00546 Adinazolam Drug2 : DB01567 Fludiazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Pharmacological target (+,+) : BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Pharmacological target (+,+) : BE0003596 Gamma-aminobutyric acid receptor subunit pi Pharmacological target (+,+) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Pharmacological target (+,+) : BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 Pharmacological target (+,+) : BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 --------------------------------------------------- Drug1 : DB00546 Adinazolam Drug2 : DB01588 Prazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Pharmacological target (+,+) : BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Pharmacological target (+,+) : BE0003596 Gamma-aminobutyric acid receptor subunit pi Pharmacological target (+,+) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Pharmacological target (+,+) : BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 Pharmacological target (+,+) : BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) --------------------------------------------------- Drug1 : DB00546 Adinazolam Drug2 : DB01589 Quazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Pharmacological target (+,+) : BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Pharmacological target (+,+) : BE0003596 Gamma-aminobutyric acid receptor subunit pi Pharmacological target (+,+) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Pharmacological target (+,+) : BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 Pharmacological target (+,+) : BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 Non-common off-target(s) (drug1) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) --------------------------------------------------- Drug1 : DB00546 Adinazolam Drug2 : DB01594 Cinolazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Pharmacological target (+,+) : BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Pharmacological target (+,+) : BE0003596 Gamma-aminobutyric acid receptor subunit pi Pharmacological target (+,+) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Pharmacological target (+,+) : BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 Pharmacological target (+,+) : BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 --------------------------------------------------- Drug1 : DB00546 Adinazolam Drug2 : DB01595 Nitrazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Pharmacological target (+,+) : BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Pharmacological target (+,+) : BE0003596 Gamma-aminobutyric acid receptor subunit pi Pharmacological target (+,+) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Pharmacological target (+,+) : BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 Pharmacological target (+,+) : BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 Non-common off-target(s) (drug2) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00547 Desoximetasone Drug2 : DB00588 Fluticasone Propionate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug2) : BE0000557 Progesterone receptor (1) BE0000668 Mineralocorticoid receptor (-1) BE0000657 Cytosolic phospholipase A2 (-1) --------------------------------------------------- Drug1 : DB00547 Desoximetasone Drug2 : DB00591 Fluocinolone Acetonide Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00547 Desoximetasone Drug2 : DB00596 Halobetasol Propionate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00547 Desoximetasone Drug2 : DB00620 Triamcinolone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00547 Desoximetasone Drug2 : DB00635 Prednisone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00547 Desoximetasone Drug2 : DB00663 Flumethasone Pivalate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00547 Desoximetasone Drug2 : DB00741 Hydrocortisone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug2) : BE0000422 Annexin A1 (1) --------------------------------------------------- Drug1 : DB00547 Desoximetasone Drug2 : DB00764 Mometasone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00547 Desoximetasone Drug2 : DB00769 Hydrocortamate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00547 Desoximetasone Drug2 : DB00838 Clocortolone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00547 Desoximetasone Drug2 : DB00846 Flurandrenolide Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00547 Desoximetasone Drug2 : DB00860 Prednisolone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00547 Desoximetasone Drug2 : DB00873 Loteprednol Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00547 Desoximetasone Drug2 : DB00896 Rimexolone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00547 Desoximetasone Drug2 : DB00959 Methylprednisolone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00547 Desoximetasone Drug2 : DB01013 Clobetasol propionate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00547 Desoximetasone Drug2 : DB01047 Fluocinonide Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug2) : BE0004659 Smoothened homolog (1) --------------------------------------------------- Drug1 : DB00547 Desoximetasone Drug2 : DB01130 Prednicarbate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00547 Desoximetasone Drug2 : DB01234 Dexamethasone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug2) : BE0000005 Nitric oxide synthase, inducible (-1) BE0000422 Annexin A1 (1) BE0000074 Nuclear receptor subfamily 0 group B member 1 (1) --------------------------------------------------- Drug1 : DB00547 Desoximetasone Drug2 : DB01260 Desonide Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00547 Desoximetasone Drug2 : DB01380 Cortisone acetate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00547 Desoximetasone Drug2 : DB01384 Paramethasone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00547 Desoximetasone Drug2 : DB01410 Ciclesonide Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00547 Desoximetasone Drug2 : DB06781 Difluprednate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00547 Desoximetasone Drug2 : DB08906 Fluticasone furoate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00549 Zafirlukast Drug2 : DB00587 Cinalukast Pharmacological target (-,-) : BE0000705 Cysteinyl leukotriene receptor 1 --------------------------------------------------- Drug1 : DB00549 Zafirlukast Drug2 : DB00716 Nedocromil Pharmacological target (-,-) : BE0000705 Cysteinyl leukotriene receptor 1 Non-common off-target(s) (drug2) : BE0000099 Cysteinyl leukotriene receptor 2 (-1) BE0000995 fMet-Leu-Phe receptor (-1) --------------------------------------------------- Drug1 : DB00549 Zafirlukast Drug2 : DB01411 Pranlukast Pharmacological target (-,-) : BE0000705 Cysteinyl leukotriene receptor 1 Non-common off-target(s) (drug2) : BE0001208 Interleukin-5 (-1) --------------------------------------------------- Drug1 : DB00550 Propylthiouracil Drug2 : DB00763 Methimazole Pharmacological target (-,-) : BE0000507 Thyroid peroxidase --------------------------------------------------- Drug1 : DB00554 Piroxicam Drug2 : DB00580 Valdecoxib Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) --------------------------------------------------- Drug1 : DB00554 Piroxicam Drug2 : DB01050 Ibuprofen Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) Non-common off-target(s) (drug2) : BE0001088 Tissue-type plasminogen activator (-1) BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0001195 Cystic fibrosis transmembrane conductance regulator (-1) --------------------------------------------------- Drug1 : DB00554 Piroxicam Drug2 : DB01628 Etoricoxib Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) --------------------------------------------------- Drug1 : DB00554 Piroxicam Drug2 : DB04552 Niflumic Acid Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) Non-common off-target(s) (drug2) : BE0003997 Phospholipase A2 (-1) BE0002376 Chloride channel protein ClC-Ka (1) --------------------------------------------------- Drug1 : DB00554 Piroxicam Drug2 : DB04743 Nimesulide Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) --------------------------------------------------- Drug1 : DB00557 Hydroxyzine Drug2 : DB00637 Astemizole Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) --------------------------------------------------- Drug1 : DB00557 Hydroxyzine Drug2 : DB00719 Azatadine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00557 Hydroxyzine Drug2 : DB00737 Meclizine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00557 Hydroxyzine Drug2 : DB00748 Carbinoxamine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00557 Hydroxyzine Drug2 : DB00751 Epinastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000112 Histamine H2 receptor (-1) --------------------------------------------------- Drug1 : DB00557 Hydroxyzine Drug2 : DB00768 Olopatadine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0001090 Protein S100-A1 (-1) BE0001206 Protein S100-A12 (-1) BE0003602 Protein S100-A2 (-1) --------------------------------------------------- Drug1 : DB00557 Hydroxyzine Drug2 : DB00777 Propiomazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00557 Hydroxyzine Drug2 : DB00792 Tripelennamine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00557 Hydroxyzine Drug2 : DB00835 Brompheniramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00557 Hydroxyzine Drug2 : DB00902 Methdilazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00557 Hydroxyzine Drug2 : DB00950 Fexofenadine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00557 Hydroxyzine Drug2 : DB00967 Desloratadine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00557 Hydroxyzine Drug2 : DB00972 Azelastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00557 Hydroxyzine Drug2 : DB00985 Dimenhydrinate Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00557 Hydroxyzine Drug2 : DB01069 Promethazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00557 Hydroxyzine Drug2 : DB01071 Mequitazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00557 Hydroxyzine Drug2 : DB01075 Diphenhydramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00557 Hydroxyzine Drug2 : DB01084 Emedastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00557 Hydroxyzine Drug2 : DB01106 Levocabastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000464 Neurotensin receptor type 2 (-1) --------------------------------------------------- Drug1 : DB00557 Hydroxyzine Drug2 : DB01114 Chlorphenamine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB00557 Hydroxyzine Drug2 : DB01146 Diphenylpyraline Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB00557 Hydroxyzine Drug2 : DB01176 Cyclizine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000951 Estrogen sulfotransferase (-1) --------------------------------------------------- Drug1 : DB00557 Hydroxyzine Drug2 : DB01237 Bromodiphenhydramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00557 Hydroxyzine Drug2 : DB01246 Alimemazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00557 Hydroxyzine Drug2 : DB01615 Aceprometazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00557 Hydroxyzine Drug2 : DB01619 Phenindamine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00557 Hydroxyzine Drug2 : DB01620 Pheniramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00557 Hydroxyzine Drug2 : DB04837 Clofedanol Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00557 Hydroxyzine Drug2 : DB04890 Bepotastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00557 Hydroxyzine Drug2 : DB06691 Mepyramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00557 Hydroxyzine Drug2 : DB08799 Antazoline Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00557 Hydroxyzine Drug2 : DB08800 Chloropyramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00557 Hydroxyzine Drug2 : DB08801 Dimetindene Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00557 Hydroxyzine Drug2 : DB08802 Isothipendyl Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00557 Hydroxyzine Drug2 : DB08936 Chlorcyclizine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00559 Bosentan Drug2 : DB08932 MACITENTAN Pharmacological target (-,-) : BE0000521 Endothelin-1 receptor Pharmacological target (-,-) : BE0000043 Endothelin B receptor --------------------------------------------------- Drug1 : DB00562 Benzthiazide Drug2 : DB01324 Polythiazide Pharmacological target (-,-) : BE0000419 Solute carrier family 12 member 3 Non-common off-target(s) (drug1) : BE0000267 Carbonic anhydrase 1 (-1) BE0000322 Carbonic anhydrase 2 (-1) BE0000535 Carbonic anhydrase 4 (-1) BE0002437 Carbonic anhydrase 9 (-1) BE0001653 Carbonic anhydrase 12 (-1) --------------------------------------------------- Drug1 : DB00563 Methotrexate Drug2 : DB01131 Proguanil Pharmacological target (-,-) : BE0000330 Dihydrofolate reductase --------------------------------------------------- Drug1 : DB00563 Methotrexate Drug2 : DB01157 Trimetrexate Pharmacological target (-,-) : BE0000330 Dihydrofolate reductase --------------------------------------------------- Drug1 : DB00563 Methotrexate Drug2 : DB06813 Pralatrexate Pharmacological target (-,-) : BE0000330 Dihydrofolate reductase Non-common off-target(s) (drug2) : BE0000324 Thymidylate synthase (-1) --------------------------------------------------- Drug1 : DB00564 Carbamazepine Drug2 : DB00680 Moricizine Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha --------------------------------------------------- Drug1 : DB00564 Carbamazepine Drug2 : DB00740 Riluzole Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug2) : BE0000030 Cystine/glutamate transporter (1) --------------------------------------------------- Drug1 : DB00564 Carbamazepine Drug2 : DB00750 Prilocaine Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha --------------------------------------------------- Drug1 : DB00564 Carbamazepine Drug2 : DB00754 Ethotoin Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha --------------------------------------------------- Drug1 : DB00564 Carbamazepine Drug2 : DB00776 Oxcarbazepine Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha --------------------------------------------------- Drug1 : DB00564 Carbamazepine Drug2 : DB00908 Quinidine Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug2) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000154 Potassium channel subfamily K member 1 (-1) BE0000680 Potassium channel subfamily K member 6 (-1) --------------------------------------------------- Drug1 : DB00564 Carbamazepine Drug2 : DB01056 Tocainide Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha --------------------------------------------------- Drug1 : DB00564 Carbamazepine Drug2 : DB01182 Propafenone Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug2) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) --------------------------------------------------- Drug1 : DB00564 Carbamazepine Drug2 : DB01195 Flecainide Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug2) : BE0002083 Sodium channel protein type 4 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00564 Carbamazepine Drug2 : DB01228 Encainide Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha --------------------------------------------------- Drug1 : DB00564 Carbamazepine Drug2 : DB01320 Fosphenytoin Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha --------------------------------------------------- Drug1 : DB00564 Carbamazepine Drug2 : DB01426 Ajmaline Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha --------------------------------------------------- Drug1 : DB00564 Carbamazepine Drug2 : DB01429 Aprindine Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug2) : BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00565 Cisatracurium Besylate Drug2 : DB00657 Mecamylamine Pharmacological target (-,-) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 --------------------------------------------------- Drug1 : DB00565 Cisatracurium Besylate Drug2 : DB00728 Rocuronium Pharmacological target (-,-) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 Non-common off-target(s) (drug2) : BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) --------------------------------------------------- Drug1 : DB00565 Cisatracurium Besylate Drug2 : DB00732 Atracurium Pharmacological target (-,-) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 --------------------------------------------------- Drug1 : DB00565 Cisatracurium Besylate Drug2 : DB00810 Biperiden Pharmacological target (-,-) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 Non-common off-target(s) (drug2) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) --------------------------------------------------- Drug1 : DB00565 Cisatracurium Besylate Drug2 : DB01135 Doxacurium chloride Pharmacological target (-,-) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 Non-common off-target(s) (drug2) : BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00565 Cisatracurium Besylate Drug2 : DB01199 Tubocurarine Pharmacological target (-,-) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 Non-common off-target(s) (drug2) : BE0000426 Acetylcholinesterase (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) --------------------------------------------------- Drug1 : DB00565 Cisatracurium Besylate Drug2 : DB01226 Mivacurium Pharmacological target (-,-) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) --------------------------------------------------- Drug1 : DB00565 Cisatracurium Besylate Drug2 : DB01336 Metocurine Pharmacological target (-,-) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 Non-common off-target(s) (drug2) : BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00565 Cisatracurium Besylate Drug2 : DB01337 Pancuronium Pharmacological target (-,-) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00565 Cisatracurium Besylate Drug2 : DB01338 Pipecuronium Pharmacological target (-,-) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00565 Cisatracurium Besylate Drug2 : DB01339 Vecuronium Pharmacological target (-,-) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 --------------------------------------------------- Drug1 : DB00568 Cinnarizine Drug2 : DB01388 Mibefradil Pharmacological target (-,-) : BE0000430 Voltage-dependent L-type calcium channel subunit alpha-1C Pharmacological target (-,-) : BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H Pharmacological target (-,-) : BE0002359 Voltage-dependent L-type calcium channel subunit alpha-1D Pharmacological target (-,-) : BE0002355 Voltage-dependent L-type calcium channel subunit alpha-1S Pharmacological target (-,-) : BE0000483 Voltage-dependent T-type calcium channel subunit alpha-1G Pharmacological target (-,-) : BE0002357 Voltage-dependent L-type calcium channel subunit alpha-1F Pharmacological target (-,-) : BE0000012 Voltage-dependent T-type calcium channel subunit alpha-1I Non-common off-target(s) (drug1) : BE0000442 Histamine H1 receptor (-1) Non-common off-target(s) (drug2) : BE0002354 Voltage-dependent L-type calcium channel subunit beta-2 (-1) BE0000303 Voltage-dependent L-type calcium channel subunit beta-1 (-1) BE0002358 Voltage-dependent L-type calcium channel subunit beta-3 (-1) BE0002356 Voltage-dependent L-type calcium channel subunit beta-4 (-1) --------------------------------------------------- Drug1 : DB00569 Fondaparinux sodium Drug2 : DB01109 Heparin Pharmacological target (+,+) : BE0000280 Antithrombin-III Pharmacological target (-,-) : BE0000216 Coagulation factor X Non-common off-target(s) (drug2) : BE0001159 P-selectin (-1) --------------------------------------------------- Drug1 : DB00569 Fondaparinux sodium Drug2 : DB01225 Enoxaparin Pharmacological target (+,+) : BE0000280 Antithrombin-III Pharmacological target (-,-) : BE0000216 Coagulation factor X --------------------------------------------------- Drug1 : DB00569 Fondaparinux sodium Drug2 : DB06228 Rivaroxaban Pharmacological target (-,-) : BE0000216 Coagulation factor X Non-common off-target(s) (drug1) : BE0000280 Antithrombin-III (1) --------------------------------------------------- Drug1 : DB00569 Fondaparinux sodium Drug2 : DB06271 Sulodexide Pharmacological target (+,+) : BE0000280 Antithrombin-III Non-common off-target(s) (drug1) : BE0000216 Coagulation factor X (-1) Non-common off-target(s) (drug2) : BE0000775 Heparin cofactor 2 (1) --------------------------------------------------- Drug1 : DB00569 Fondaparinux sodium Drug2 : DB06605 Apixaban Pharmacological target (-,-) : BE0000216 Coagulation factor X Non-common off-target(s) (drug1) : BE0000280 Antithrombin-III (1) --------------------------------------------------- Drug1 : DB00569 Fondaparinux sodium Drug2 : DB06822 Tinzaparin Pharmacological target (+,+) : BE0000280 Antithrombin-III Non-common off-target(s) (drug1) : BE0000216 Coagulation factor X (-1) Non-common off-target(s) (drug2) : BE0000590 Integrin alpha-4 (-1) --------------------------------------------------- Drug1 : DB00569 Fondaparinux sodium Drug2 : DB08813 Nadroparin Pharmacological target (+,+) : BE0000280 Antithrombin-III Non-common off-target(s) (drug1) : BE0000216 Coagulation factor X (-1) Non-common off-target(s) (drug2) : BE0001159 P-selectin (-1) BE0001126 Proto-oncogene c-Fos (-1) BE0004689 Myc proto-oncogene protein (-1) --------------------------------------------------- Drug1 : DB00569 Fondaparinux sodium Drug2 : DB09075 Edoxaban Pharmacological target (-,-) : BE0000216 Coagulation factor X Non-common off-target(s) (drug1) : BE0000280 Antithrombin-III (1) --------------------------------------------------- Drug1 : DB00571 Propranolol Drug2 : DB01297 Practolol Pharmacological target (-,-) : BE0000172 Beta-1 adrenergic receptor Non-common off-target(s) (drug1) : BE0000694 Beta-2 adrenergic receptor (-1) BE0001012 Beta-3 adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00572 Atropine Drug2 : DB00725 Homatropine Methylbromide Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Pharmacological target (-,-) : BE0000405 Muscarinic acetylcholine receptor M4 Pharmacological target (-,-) : BE0000247 Muscarinic acetylcholine receptor M5 --------------------------------------------------- Drug1 : DB00572 Atropine Drug2 : DB00767 Benzquinamide Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Pharmacological target (-,-) : BE0000405 Muscarinic acetylcholine receptor M4 Pharmacological target (-,-) : BE0000247 Muscarinic acetylcholine receptor M5 Non-common off-target(s) (drug2) : BE0000442 Histamine H1 receptor (-1) --------------------------------------------------- Drug1 : DB00572 Atropine Drug2 : DB00785 Cryptenamine Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Pharmacological target (-,-) : BE0000405 Muscarinic acetylcholine receptor M4 Pharmacological target (-,-) : BE0000247 Muscarinic acetylcholine receptor M5 --------------------------------------------------- Drug1 : DB00572 Atropine Drug2 : DB01036 Tolterodine Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Pharmacological target (-,-) : BE0000405 Muscarinic acetylcholine receptor M4 Pharmacological target (-,-) : BE0000247 Muscarinic acetylcholine receptor M5 --------------------------------------------------- Drug1 : DB00572 Atropine Drug2 : DB01062 Oxybutynin Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00572 Atropine Drug2 : DB01231 Diphenidol Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00572 Atropine Drug2 : DB08897 Aclidinium Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Pharmacological target (-,-) : BE0000405 Muscarinic acetylcholine receptor M4 Pharmacological target (-,-) : BE0000247 Muscarinic acetylcholine receptor M5 --------------------------------------------------- Drug1 : DB00573 Fenoprofen Drug2 : DB00580 Valdecoxib Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) --------------------------------------------------- Drug1 : DB00573 Fenoprofen Drug2 : DB01050 Ibuprofen Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) Non-common off-target(s) (drug2) : BE0001088 Tissue-type plasminogen activator (-1) BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0001195 Cystic fibrosis transmembrane conductance regulator (-1) --------------------------------------------------- Drug1 : DB00573 Fenoprofen Drug2 : DB01628 Etoricoxib Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) --------------------------------------------------- Drug1 : DB00573 Fenoprofen Drug2 : DB04552 Niflumic Acid Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) Non-common off-target(s) (drug2) : BE0003997 Phospholipase A2 (-1) BE0002376 Chloride channel protein ClC-Ka (1) --------------------------------------------------- Drug1 : DB00573 Fenoprofen Drug2 : DB04743 Nimesulide Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) --------------------------------------------------- Drug1 : DB00574 Fenfluramine Drug2 : DB00656 Trazodone Pharmacological target (+,+) : BE0000533 5-hydroxytryptamine receptor 2C Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug1) : BE0000393 5-hydroxytryptamine receptor 2B (1) Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00579 Mazindol Drug2 : DB00830 Phenmetrazine Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) --------------------------------------------------- Drug1 : DB00579 Mazindol Drug2 : DB00852 Pseudoephedrine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug2) : BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00579 Mazindol Drug2 : DB00907 Cocaine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug2) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000197 Sodium channel protein type 5 subunit alpha (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) BE0000192 Sodium channel protein type 11 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00579 Mazindol Drug2 : DB00937 Diethylpropion Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) --------------------------------------------------- Drug1 : DB00579 Mazindol Drug2 : DB01105 Sibutramine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter --------------------------------------------------- Drug1 : DB00579 Mazindol Drug2 : DB01151 Desipramine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000694 Beta-2 adrenergic receptor (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000442 Histamine H1 receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0004863 Alpha-1 adrenergic receptor (-1) BE0000973 Sphingomyelin phosphodiesterase (-1) --------------------------------------------------- Drug1 : DB00579 Mazindol Drug2 : DB01156 Bupropion Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) Non-common off-target(s) (drug2) : BE0003585 Neuronal acetylcholine receptor subunit alpha-3 (-1) --------------------------------------------------- Drug1 : DB00579 Mazindol Drug2 : DB01576 Dextroamphetamine Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (1) BE0001044 Trace amine-associated receptor 1 (1) BE0000575 Alpha-1B adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00579 Mazindol Drug2 : DB04896 Milnacipran Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) Non-common off-target(s) (drug2) : BE0004956 NMDA receptor (-1) --------------------------------------------------- Drug1 : DB00579 Mazindol Drug2 : DB06700 Desvenlafaxine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB00579 Mazindol Drug2 : DB08918 Levomilnacipran Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB00580 Valdecoxib Drug2 : DB00605 Sulindac Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug2) : BE0000017 Prostaglandin G/H synthase 1 (-1) BE0000747 Aldose reductase (-1) BE0001007 Peroxisome proliferator-activated receptor delta (-1) BE0003561 Prostaglandin D2 receptor 2 (-1) BE0001062 Mitogen-activated protein kinase 3 (-1) --------------------------------------------------- Drug1 : DB00580 Valdecoxib Drug2 : DB00712 Flurbiprofen Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug2) : BE0000017 Prostaglandin G/H synthase 1 (-1) --------------------------------------------------- Drug1 : DB00580 Valdecoxib Drug2 : DB00749 Etodolac Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug2) : BE0000017 Prostaglandin G/H synthase 1 (-1) --------------------------------------------------- Drug1 : DB00580 Valdecoxib Drug2 : DB00784 Mefenamic acid Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug2) : BE0000017 Prostaglandin G/H synthase 1 (-1) --------------------------------------------------- Drug1 : DB00580 Valdecoxib Drug2 : DB00788 Naproxen Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug2) : BE0000017 Prostaglandin G/H synthase 1 (-1) --------------------------------------------------- Drug1 : DB00580 Valdecoxib Drug2 : DB00814 Meloxicam Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug2) : BE0000017 Prostaglandin G/H synthase 1 (-1) --------------------------------------------------- Drug1 : DB00580 Valdecoxib Drug2 : DB00821 Carprofen Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug2) : BE0000017 Prostaglandin G/H synthase 1 (-1) --------------------------------------------------- Drug1 : DB00580 Valdecoxib Drug2 : DB00861 Diflunisal Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug2) : BE0000017 Prostaglandin G/H synthase 1 (-1) --------------------------------------------------- Drug1 : DB00580 Valdecoxib Drug2 : DB00870 Suprofen Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug2) : BE0000017 Prostaglandin G/H synthase 1 (-1) --------------------------------------------------- Drug1 : DB00580 Valdecoxib Drug2 : DB00936 Salicylic acid Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug2) : BE0000017 Prostaglandin G/H synthase 1 (-1) BE0000126 Aldo-keto reductase family 1 member C1 (-1) --------------------------------------------------- Drug1 : DB00580 Valdecoxib Drug2 : DB00945 Acetylsalicylic acid Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug2) : BE0000017 Prostaglandin G/H synthase 1 (-1) BE0000126 Aldo-keto reductase family 1 member C1 (-1) BE0004907 5'-AMP-activated protein kinase (1) BE0004903 Nuclear factor NF-kappa-B (-1) --------------------------------------------------- Drug1 : DB00580 Valdecoxib Drug2 : DB00963 Bromfenac Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug2) : BE0000017 Prostaglandin G/H synthase 1 (-1) --------------------------------------------------- Drug1 : DB00580 Valdecoxib Drug2 : DB00991 Oxaprozin Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug2) : BE0000017 Prostaglandin G/H synthase 1 (-1) --------------------------------------------------- Drug1 : DB00580 Valdecoxib Drug2 : DB01009 Ketoprofen Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug2) : BE0000017 Prostaglandin G/H synthase 1 (-1) --------------------------------------------------- Drug1 : DB00580 Valdecoxib Drug2 : DB01050 Ibuprofen Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug2) : BE0001088 Tissue-type plasminogen activator (-1) BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0001195 Cystic fibrosis transmembrane conductance regulator (-1) --------------------------------------------------- Drug1 : DB00580 Valdecoxib Drug2 : DB01283 Lumiracoxib Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug2) : BE0000017 Prostaglandin G/H synthase 1 (-1) --------------------------------------------------- Drug1 : DB00580 Valdecoxib Drug2 : DB01397 Magnesium salicylate Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug2) : BE0000017 Prostaglandin G/H synthase 1 (-1) --------------------------------------------------- Drug1 : DB00580 Valdecoxib Drug2 : DB01398 Salicylate-sodium Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug2) : BE0000017 Prostaglandin G/H synthase 1 (-1) --------------------------------------------------- Drug1 : DB00580 Valdecoxib Drug2 : DB01399 Salsalate Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug2) : BE0000017 Prostaglandin G/H synthase 1 (-1) --------------------------------------------------- Drug1 : DB00580 Valdecoxib Drug2 : DB01600 Tiaprofenic acid Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug2) : BE0000017 Prostaglandin G/H synthase 1 (-1) --------------------------------------------------- Drug1 : DB00580 Valdecoxib Drug2 : DB01628 Etoricoxib Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 --------------------------------------------------- Drug1 : DB00580 Valdecoxib Drug2 : DB04552 Niflumic Acid Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug2) : BE0003997 Phospholipase A2 (-1) BE0002376 Chloride channel protein ClC-Ka (1) --------------------------------------------------- Drug1 : DB00580 Valdecoxib Drug2 : DB04743 Nimesulide Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 --------------------------------------------------- Drug1 : DB00580 Valdecoxib Drug2 : DB06725 Lornoxicam Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug2) : BE0000017 Prostaglandin G/H synthase 1 (-1) --------------------------------------------------- Drug1 : DB00584 Enalapril Drug2 : DB00691 Moexipril Pharmacological target (-,-) : BE0000221 Angiotensin-converting enzyme Non-common off-target(s) (drug2) : BE0000982 Angiotensin-converting enzyme 2 (-1) --------------------------------------------------- Drug1 : DB00584 Enalapril Drug2 : DB00722 Lisinopril Pharmacological target (-,-) : BE0000221 Angiotensin-converting enzyme Non-common off-target(s) (drug2) : BE0000982 Angiotensin-converting enzyme 2 (-1) --------------------------------------------------- Drug1 : DB00584 Enalapril Drug2 : DB00790 Perindopril Pharmacological target (-,-) : BE0000221 Angiotensin-converting enzyme --------------------------------------------------- Drug1 : DB00584 Enalapril Drug2 : DB00881 Quinapril Pharmacological target (-,-) : BE0000221 Angiotensin-converting enzyme --------------------------------------------------- Drug1 : DB00584 Enalapril Drug2 : DB01180 Rescinnamine Pharmacological target (-,-) : BE0000221 Angiotensin-converting enzyme --------------------------------------------------- Drug1 : DB00584 Enalapril Drug2 : DB01197 Captopril Pharmacological target (-,-) : BE0000221 Angiotensin-converting enzyme Non-common off-target(s) (drug2) : BE0000642 72 kDa type IV collagenase (-1) BE0000058 Matrix metalloproteinase-9 (-1) --------------------------------------------------- Drug1 : DB00584 Enalapril Drug2 : DB01340 Cilazapril Pharmacological target (-,-) : BE0000221 Angiotensin-converting enzyme --------------------------------------------------- Drug1 : DB00584 Enalapril Drug2 : DB01348 Spirapril Pharmacological target (-,-) : BE0000221 Angiotensin-converting enzyme --------------------------------------------------- Drug1 : DB00585 Nizatidine Drug2 : DB00751 Epinastine Pharmacological target (-,-) : BE0000112 Histamine H2 receptor Non-common off-target(s) (drug2) : BE0000442 Histamine H1 receptor (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB00585 Nizatidine Drug2 : DB00863 Ranitidine Pharmacological target (-,-) : BE0000112 Histamine H2 receptor --------------------------------------------------- Drug1 : DB00585 Nizatidine Drug2 : DB00927 Famotidine Pharmacological target (-,-) : BE0000112 Histamine H2 receptor --------------------------------------------------- Drug1 : DB00585 Nizatidine Drug2 : DB00940 Methantheline Pharmacological target (-,-) : BE0000112 Histamine H2 receptor Non-common off-target(s) (drug2) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) --------------------------------------------------- Drug1 : DB00585 Nizatidine Drug2 : DB08805 Metiamide Pharmacological target (-,-) : BE0000112 Histamine H2 receptor --------------------------------------------------- Drug1 : DB00585 Nizatidine Drug2 : DB08806 Roxatidine acetate Pharmacological target (-,-) : BE0000112 Histamine H2 receptor --------------------------------------------------- Drug1 : DB00587 Cinalukast Drug2 : DB00716 Nedocromil Pharmacological target (-,-) : BE0000705 Cysteinyl leukotriene receptor 1 Non-common off-target(s) (drug2) : BE0000099 Cysteinyl leukotriene receptor 2 (-1) BE0000995 fMet-Leu-Phe receptor (-1) --------------------------------------------------- Drug1 : DB00587 Cinalukast Drug2 : DB01411 Pranlukast Pharmacological target (-,-) : BE0000705 Cysteinyl leukotriene receptor 1 Non-common off-target(s) (drug2) : BE0001208 Interleukin-5 (-1) --------------------------------------------------- Drug1 : DB00588 Fluticasone Propionate Drug2 : DB00591 Fluocinolone Acetonide Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug1) : BE0000557 Progesterone receptor (1) BE0000668 Mineralocorticoid receptor (-1) BE0000657 Cytosolic phospholipase A2 (-1) --------------------------------------------------- Drug1 : DB00588 Fluticasone Propionate Drug2 : DB00596 Halobetasol Propionate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug1) : BE0000557 Progesterone receptor (1) BE0000668 Mineralocorticoid receptor (-1) BE0000657 Cytosolic phospholipase A2 (-1) --------------------------------------------------- Drug1 : DB00588 Fluticasone Propionate Drug2 : DB00620 Triamcinolone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug1) : BE0000557 Progesterone receptor (1) BE0000668 Mineralocorticoid receptor (-1) BE0000657 Cytosolic phospholipase A2 (-1) --------------------------------------------------- Drug1 : DB00588 Fluticasone Propionate Drug2 : DB00635 Prednisone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug1) : BE0000557 Progesterone receptor (1) BE0000668 Mineralocorticoid receptor (-1) BE0000657 Cytosolic phospholipase A2 (-1) --------------------------------------------------- Drug1 : DB00588 Fluticasone Propionate Drug2 : DB00663 Flumethasone Pivalate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug1) : BE0000557 Progesterone receptor (1) BE0000668 Mineralocorticoid receptor (-1) BE0000657 Cytosolic phospholipase A2 (-1) --------------------------------------------------- Drug1 : DB00588 Fluticasone Propionate Drug2 : DB00741 Hydrocortisone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug1) : BE0000557 Progesterone receptor (1) BE0000668 Mineralocorticoid receptor (-1) BE0000657 Cytosolic phospholipase A2 (-1) Non-common off-target(s) (drug2) : BE0000422 Annexin A1 (1) --------------------------------------------------- Drug1 : DB00588 Fluticasone Propionate Drug2 : DB00764 Mometasone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug1) : BE0000557 Progesterone receptor (1) BE0000668 Mineralocorticoid receptor (-1) BE0000657 Cytosolic phospholipase A2 (-1) --------------------------------------------------- Drug1 : DB00588 Fluticasone Propionate Drug2 : DB00769 Hydrocortamate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug1) : BE0000557 Progesterone receptor (1) BE0000668 Mineralocorticoid receptor (-1) BE0000657 Cytosolic phospholipase A2 (-1) --------------------------------------------------- Drug1 : DB00588 Fluticasone Propionate Drug2 : DB00838 Clocortolone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug1) : BE0000557 Progesterone receptor (1) BE0000668 Mineralocorticoid receptor (-1) BE0000657 Cytosolic phospholipase A2 (-1) --------------------------------------------------- Drug1 : DB00588 Fluticasone Propionate Drug2 : DB00846 Flurandrenolide Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug1) : BE0000557 Progesterone receptor (1) BE0000668 Mineralocorticoid receptor (-1) BE0000657 Cytosolic phospholipase A2 (-1) --------------------------------------------------- Drug1 : DB00588 Fluticasone Propionate Drug2 : DB00860 Prednisolone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug1) : BE0000557 Progesterone receptor (1) BE0000668 Mineralocorticoid receptor (-1) BE0000657 Cytosolic phospholipase A2 (-1) --------------------------------------------------- Drug1 : DB00588 Fluticasone Propionate Drug2 : DB00873 Loteprednol Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug1) : BE0000557 Progesterone receptor (1) BE0000668 Mineralocorticoid receptor (-1) BE0000657 Cytosolic phospholipase A2 (-1) --------------------------------------------------- Drug1 : DB00588 Fluticasone Propionate Drug2 : DB00896 Rimexolone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug1) : BE0000557 Progesterone receptor (1) BE0000668 Mineralocorticoid receptor (-1) BE0000657 Cytosolic phospholipase A2 (-1) --------------------------------------------------- Drug1 : DB00588 Fluticasone Propionate Drug2 : DB00959 Methylprednisolone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug1) : BE0000557 Progesterone receptor (1) BE0000668 Mineralocorticoid receptor (-1) BE0000657 Cytosolic phospholipase A2 (-1) --------------------------------------------------- Drug1 : DB00588 Fluticasone Propionate Drug2 : DB01013 Clobetasol propionate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug1) : BE0000557 Progesterone receptor (1) BE0000668 Mineralocorticoid receptor (-1) BE0000657 Cytosolic phospholipase A2 (-1) --------------------------------------------------- Drug1 : DB00588 Fluticasone Propionate Drug2 : DB01047 Fluocinonide Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug1) : BE0000557 Progesterone receptor (1) BE0000668 Mineralocorticoid receptor (-1) BE0000657 Cytosolic phospholipase A2 (-1) Non-common off-target(s) (drug2) : BE0004659 Smoothened homolog (1) --------------------------------------------------- Drug1 : DB00588 Fluticasone Propionate Drug2 : DB01130 Prednicarbate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug1) : BE0000557 Progesterone receptor (1) BE0000668 Mineralocorticoid receptor (-1) BE0000657 Cytosolic phospholipase A2 (-1) --------------------------------------------------- Drug1 : DB00588 Fluticasone Propionate Drug2 : DB01234 Dexamethasone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug1) : BE0000557 Progesterone receptor (1) BE0000668 Mineralocorticoid receptor (-1) BE0000657 Cytosolic phospholipase A2 (-1) Non-common off-target(s) (drug2) : BE0000005 Nitric oxide synthase, inducible (-1) BE0000422 Annexin A1 (1) BE0000074 Nuclear receptor subfamily 0 group B member 1 (1) --------------------------------------------------- Drug1 : DB00588 Fluticasone Propionate Drug2 : DB01260 Desonide Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug1) : BE0000557 Progesterone receptor (1) BE0000668 Mineralocorticoid receptor (-1) BE0000657 Cytosolic phospholipase A2 (-1) --------------------------------------------------- Drug1 : DB00588 Fluticasone Propionate Drug2 : DB01380 Cortisone acetate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug1) : BE0000557 Progesterone receptor (1) BE0000668 Mineralocorticoid receptor (-1) BE0000657 Cytosolic phospholipase A2 (-1) --------------------------------------------------- Drug1 : DB00588 Fluticasone Propionate Drug2 : DB01384 Paramethasone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug1) : BE0000557 Progesterone receptor (1) BE0000668 Mineralocorticoid receptor (-1) BE0000657 Cytosolic phospholipase A2 (-1) --------------------------------------------------- Drug1 : DB00588 Fluticasone Propionate Drug2 : DB01410 Ciclesonide Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug1) : BE0000557 Progesterone receptor (1) BE0000668 Mineralocorticoid receptor (-1) BE0000657 Cytosolic phospholipase A2 (-1) --------------------------------------------------- Drug1 : DB00588 Fluticasone Propionate Drug2 : DB06781 Difluprednate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug1) : BE0000557 Progesterone receptor (1) BE0000668 Mineralocorticoid receptor (-1) BE0000657 Cytosolic phospholipase A2 (-1) --------------------------------------------------- Drug1 : DB00588 Fluticasone Propionate Drug2 : DB08906 Fluticasone furoate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug1) : BE0000557 Progesterone receptor (1) BE0000668 Mineralocorticoid receptor (-1) BE0000657 Cytosolic phospholipase A2 (-1) --------------------------------------------------- Drug1 : DB00591 Fluocinolone Acetonide Drug2 : DB00596 Halobetasol Propionate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00591 Fluocinolone Acetonide Drug2 : DB00620 Triamcinolone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00591 Fluocinolone Acetonide Drug2 : DB00635 Prednisone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00591 Fluocinolone Acetonide Drug2 : DB00663 Flumethasone Pivalate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00591 Fluocinolone Acetonide Drug2 : DB00741 Hydrocortisone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug2) : BE0000422 Annexin A1 (1) --------------------------------------------------- Drug1 : DB00591 Fluocinolone Acetonide Drug2 : DB00764 Mometasone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00591 Fluocinolone Acetonide Drug2 : DB00769 Hydrocortamate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00591 Fluocinolone Acetonide Drug2 : DB00838 Clocortolone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00591 Fluocinolone Acetonide Drug2 : DB00846 Flurandrenolide Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00591 Fluocinolone Acetonide Drug2 : DB00860 Prednisolone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00591 Fluocinolone Acetonide Drug2 : DB00873 Loteprednol Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00591 Fluocinolone Acetonide Drug2 : DB00896 Rimexolone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00591 Fluocinolone Acetonide Drug2 : DB00959 Methylprednisolone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00591 Fluocinolone Acetonide Drug2 : DB01013 Clobetasol propionate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00591 Fluocinolone Acetonide Drug2 : DB01047 Fluocinonide Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug2) : BE0004659 Smoothened homolog (1) --------------------------------------------------- Drug1 : DB00591 Fluocinolone Acetonide Drug2 : DB01130 Prednicarbate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00591 Fluocinolone Acetonide Drug2 : DB01234 Dexamethasone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug2) : BE0000005 Nitric oxide synthase, inducible (-1) BE0000422 Annexin A1 (1) BE0000074 Nuclear receptor subfamily 0 group B member 1 (1) --------------------------------------------------- Drug1 : DB00591 Fluocinolone Acetonide Drug2 : DB01260 Desonide Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00591 Fluocinolone Acetonide Drug2 : DB01380 Cortisone acetate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00591 Fluocinolone Acetonide Drug2 : DB01384 Paramethasone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00591 Fluocinolone Acetonide Drug2 : DB01410 Ciclesonide Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00591 Fluocinolone Acetonide Drug2 : DB06781 Difluprednate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00591 Fluocinolone Acetonide Drug2 : DB08906 Fluticasone furoate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00592 Piperazine Drug2 : DB06716 Fospropofol Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Non-common off-target(s) (drug2) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) --------------------------------------------------- Drug1 : DB00593 Ethosuximide Drug2 : DB05246 Methsuximide Pharmacological target (-,-) : BE0000483 Voltage-dependent T-type calcium channel subunit alpha-1G --------------------------------------------------- Drug1 : DB00596 Halobetasol Propionate Drug2 : DB00620 Triamcinolone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00596 Halobetasol Propionate Drug2 : DB00635 Prednisone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00596 Halobetasol Propionate Drug2 : DB00663 Flumethasone Pivalate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00596 Halobetasol Propionate Drug2 : DB00741 Hydrocortisone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug2) : BE0000422 Annexin A1 (1) --------------------------------------------------- Drug1 : DB00596 Halobetasol Propionate Drug2 : DB00764 Mometasone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00596 Halobetasol Propionate Drug2 : DB00769 Hydrocortamate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00596 Halobetasol Propionate Drug2 : DB00838 Clocortolone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00596 Halobetasol Propionate Drug2 : DB00846 Flurandrenolide Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00596 Halobetasol Propionate Drug2 : DB00860 Prednisolone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00596 Halobetasol Propionate Drug2 : DB00873 Loteprednol Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00596 Halobetasol Propionate Drug2 : DB00896 Rimexolone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00596 Halobetasol Propionate Drug2 : DB00959 Methylprednisolone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00596 Halobetasol Propionate Drug2 : DB01013 Clobetasol propionate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00596 Halobetasol Propionate Drug2 : DB01047 Fluocinonide Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug2) : BE0004659 Smoothened homolog (1) --------------------------------------------------- Drug1 : DB00596 Halobetasol Propionate Drug2 : DB01130 Prednicarbate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00596 Halobetasol Propionate Drug2 : DB01234 Dexamethasone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug2) : BE0000005 Nitric oxide synthase, inducible (-1) BE0000422 Annexin A1 (1) BE0000074 Nuclear receptor subfamily 0 group B member 1 (1) --------------------------------------------------- Drug1 : DB00596 Halobetasol Propionate Drug2 : DB01260 Desonide Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00596 Halobetasol Propionate Drug2 : DB01380 Cortisone acetate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00596 Halobetasol Propionate Drug2 : DB01384 Paramethasone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00596 Halobetasol Propionate Drug2 : DB01410 Ciclesonide Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00596 Halobetasol Propionate Drug2 : DB06781 Difluprednate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00596 Halobetasol Propionate Drug2 : DB08906 Fluticasone furoate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00598 Labetalol Drug2 : DB00866 Alprenolol Pharmacological target (-,-) : BE0000172 Beta-1 adrenergic receptor Pharmacological target (-,-) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0004863 Alpha-1 adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000291 5-hydroxytryptamine receptor 1A (-1) --------------------------------------------------- Drug1 : DB00598 Labetalol Drug2 : DB01210 Levobunolol Pharmacological target (-,-) : BE0000172 Beta-1 adrenergic receptor Pharmacological target (-,-) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0004863 Alpha-1 adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00598 Labetalol Drug2 : DB01214 Metipranolol Pharmacological target (-,-) : BE0000172 Beta-1 adrenergic receptor Pharmacological target (-,-) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0004863 Alpha-1 adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00599 Thiopental Drug2 : DB01198 Zopiclone Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002194 Fatty-acid amide hydrolase 1 (-1) Non-common off-target(s) (drug2) : BE0000736 Translocator protein (1) --------------------------------------------------- Drug1 : DB00599 Thiopental Drug2 : DB01544 Flunitrazepam Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) BE0002194 Fatty-acid amide hydrolase 1 (-1) Non-common off-target(s) (drug2) : BE0000736 Translocator protein (1) --------------------------------------------------- Drug1 : DB00603 Medroxyprogesterone Acetate Drug2 : DB00655 Estrone Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug1) : BE0000557 Progesterone receptor (1) --------------------------------------------------- Drug1 : DB00603 Medroxyprogesterone Acetate Drug2 : DB00783 Estradiol Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug1) : BE0000557 Progesterone receptor (1) Non-common off-target(s) (drug2) : BE0000792 Estrogen receptor beta (1) --------------------------------------------------- Drug1 : DB00603 Medroxyprogesterone Acetate Drug2 : DB00823 Ethynodiol Pharmacological target (+,+) : BE0000123 Estrogen receptor Pharmacological target (+,+) : BE0000557 Progesterone receptor --------------------------------------------------- Drug1 : DB00603 Medroxyprogesterone Acetate Drug2 : DB00890 Dienestrol Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug1) : BE0000557 Progesterone receptor (1) --------------------------------------------------- Drug1 : DB00603 Medroxyprogesterone Acetate Drug2 : DB00957 Norgestimate Pharmacological target (+,+) : BE0000123 Estrogen receptor Pharmacological target (+,+) : BE0000557 Progesterone receptor --------------------------------------------------- Drug1 : DB00603 Medroxyprogesterone Acetate Drug2 : DB00977 Ethinyl Estradiol Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug1) : BE0000557 Progesterone receptor (1) Non-common off-target(s) (drug2) : BE0000956 Nuclear receptor subfamily 1 group I member 2 (1) --------------------------------------------------- Drug1 : DB00603 Medroxyprogesterone Acetate Drug2 : DB01357 Mestranol Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug1) : BE0000557 Progesterone receptor (1) --------------------------------------------------- Drug1 : DB00603 Medroxyprogesterone Acetate Drug2 : DB04573 Estriol Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug1) : BE0000557 Progesterone receptor (1) Non-common off-target(s) (drug2) : BE0000792 Estrogen receptor beta (1) --------------------------------------------------- Drug1 : DB00603 Medroxyprogesterone Acetate Drug2 : DB04574 Estropipate Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug1) : BE0000557 Progesterone receptor (1) Non-common off-target(s) (drug2) : BE0000792 Estrogen receptor beta (1) --------------------------------------------------- Drug1 : DB00603 Medroxyprogesterone Acetate Drug2 : DB04575 Quinestrol Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug1) : BE0000557 Progesterone receptor (1) --------------------------------------------------- Drug1 : DB00603 Medroxyprogesterone Acetate Drug2 : DB06713 Norelgestromin Pharmacological target (+,+) : BE0000557 Progesterone receptor Non-common off-target(s) (drug1) : BE0000123 Estrogen receptor (1) --------------------------------------------------- Drug1 : DB00605 Sulindac Drug2 : DB01050 Ibuprofen Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) BE0000747 Aldose reductase (-1) BE0001007 Peroxisome proliferator-activated receptor delta (-1) BE0003561 Prostaglandin D2 receptor 2 (-1) BE0001062 Mitogen-activated protein kinase 3 (-1) Non-common off-target(s) (drug2) : BE0001088 Tissue-type plasminogen activator (-1) BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0001195 Cystic fibrosis transmembrane conductance regulator (-1) --------------------------------------------------- Drug1 : DB00605 Sulindac Drug2 : DB01628 Etoricoxib Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) BE0000747 Aldose reductase (-1) BE0001007 Peroxisome proliferator-activated receptor delta (-1) BE0003561 Prostaglandin D2 receptor 2 (-1) BE0001062 Mitogen-activated protein kinase 3 (-1) --------------------------------------------------- Drug1 : DB00605 Sulindac Drug2 : DB04552 Niflumic Acid Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) BE0000747 Aldose reductase (-1) BE0001007 Peroxisome proliferator-activated receptor delta (-1) BE0003561 Prostaglandin D2 receptor 2 (-1) BE0001062 Mitogen-activated protein kinase 3 (-1) Non-common off-target(s) (drug2) : BE0003997 Phospholipase A2 (-1) BE0002376 Chloride channel protein ClC-Ka (1) --------------------------------------------------- Drug1 : DB00605 Sulindac Drug2 : DB04743 Nimesulide Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) BE0000747 Aldose reductase (-1) BE0001007 Peroxisome proliferator-activated receptor delta (-1) BE0003561 Prostaglandin D2 receptor 2 (-1) BE0001062 Mitogen-activated protein kinase 3 (-1) --------------------------------------------------- Drug1 : DB00610 Metaraminol Drug2 : DB00723 Methoxamine Pharmacological target (+,+) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug2) : BE0000575 Alpha-1B adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00610 Metaraminol Drug2 : DB00935 Oxymetazoline Pharmacological target (+,+) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug2) : BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00610 Metaraminol Drug2 : DB00964 Apraclonidine Pharmacological target (+,+) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug2) : BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00610 Metaraminol Drug2 : DB01253 Ergonovine Pharmacological target (+,+) : BE0000501 Alpha-1A adrenergic receptor --------------------------------------------------- Drug1 : DB00610 Metaraminol Drug2 : DB01579 Phendimetrazine Pharmacological target (+,+) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug2) : BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000575 Alpha-1B adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00610 Metaraminol Drug2 : DB06706 Isometheptene Pharmacological target (+,+) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (-1) --------------------------------------------------- Drug1 : DB00610 Metaraminol Drug2 : DB06707 Levonordefrin Pharmacological target (+,+) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug2) : BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB00610 Metaraminol Drug2 : DB06711 Naphazoline Pharmacological target (+,+) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug2) : BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00611 Butorphanol Drug2 : DB00652 Pentazocine Pharmacological target (+,+) : BE0000632 Kappa-type opioid receptor Pharmacological target (-,-) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000420 Delta-type opioid receptor (1) Non-common off-target(s) (drug2) : BE0000156 Sigma non-opioid intracellular receptor 1 (1) --------------------------------------------------- Drug1 : DB00612 Bisoprolol Drug2 : DB01297 Practolol Pharmacological target (-,-) : BE0000172 Beta-1 adrenergic receptor Non-common off-target(s) (drug1) : BE0000694 Beta-2 adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00620 Triamcinolone Drug2 : DB00635 Prednisone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00620 Triamcinolone Drug2 : DB00663 Flumethasone Pivalate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00620 Triamcinolone Drug2 : DB00741 Hydrocortisone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug2) : BE0000422 Annexin A1 (1) --------------------------------------------------- Drug1 : DB00620 Triamcinolone Drug2 : DB00764 Mometasone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00620 Triamcinolone Drug2 : DB00769 Hydrocortamate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00620 Triamcinolone Drug2 : DB00838 Clocortolone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00620 Triamcinolone Drug2 : DB00846 Flurandrenolide Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00620 Triamcinolone Drug2 : DB00860 Prednisolone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00620 Triamcinolone Drug2 : DB00873 Loteprednol Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00620 Triamcinolone Drug2 : DB00896 Rimexolone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00620 Triamcinolone Drug2 : DB00959 Methylprednisolone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00620 Triamcinolone Drug2 : DB01013 Clobetasol propionate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00620 Triamcinolone Drug2 : DB01047 Fluocinonide Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug2) : BE0004659 Smoothened homolog (1) --------------------------------------------------- Drug1 : DB00620 Triamcinolone Drug2 : DB01130 Prednicarbate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00620 Triamcinolone Drug2 : DB01234 Dexamethasone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug2) : BE0000005 Nitric oxide synthase, inducible (-1) BE0000422 Annexin A1 (1) BE0000074 Nuclear receptor subfamily 0 group B member 1 (1) --------------------------------------------------- Drug1 : DB00620 Triamcinolone Drug2 : DB01260 Desonide Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00620 Triamcinolone Drug2 : DB01380 Cortisone acetate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00620 Triamcinolone Drug2 : DB01384 Paramethasone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00620 Triamcinolone Drug2 : DB01410 Ciclesonide Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00620 Triamcinolone Drug2 : DB06781 Difluprednate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00620 Triamcinolone Drug2 : DB08906 Fluticasone furoate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00621 Oxandrolone Drug2 : DB00624 Testosterone Pharmacological target (+,+) : BE0000132 Androgen receptor --------------------------------------------------- Drug1 : DB00621 Oxandrolone Drug2 : DB00858 Drostanolone Pharmacological target (+,+) : BE0000132 Androgen receptor --------------------------------------------------- Drug1 : DB00621 Oxandrolone Drug2 : DB00984 Nandrolone phenpropionate Pharmacological target (+,+) : BE0000132 Androgen receptor --------------------------------------------------- Drug1 : DB00621 Oxandrolone Drug2 : DB01420 Testosterone Propionate Pharmacological target (+,+) : BE0000132 Androgen receptor --------------------------------------------------- Drug1 : DB00621 Oxandrolone Drug2 : DB01481 Delta1-dihydrotestosterone Pharmacological target (+,+) : BE0000132 Androgen receptor --------------------------------------------------- Drug1 : DB00621 Oxandrolone Drug2 : DB01541 Boldenone Pharmacological target (+,+) : BE0000132 Androgen receptor --------------------------------------------------- Drug1 : DB00621 Oxandrolone Drug2 : DB06710 Methyltestosterone Pharmacological target (+,+) : BE0000132 Androgen receptor --------------------------------------------------- Drug1 : DB00621 Oxandrolone Drug2 : DB08804 Nandrolone decanoate Pharmacological target (+,+) : BE0000132 Androgen receptor --------------------------------------------------- Drug1 : DB00622 Nicardipine Drug2 : DB01054 Nitrendipine Pharmacological target (-,-) : BE0000430 Voltage-dependent L-type calcium channel subunit alpha-1C Pharmacological target (-,-) : BE0000691 Voltage-dependent calcium channel subunit alpha-2/delta-1 Pharmacological target (-,-) : BE0002354 Voltage-dependent L-type calcium channel subunit beta-2 Pharmacological target (-,-) : BE0002359 Voltage-dependent L-type calcium channel subunit alpha-1D Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0003565 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (-1) BE0003323 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (-1) Non-common off-target(s) (drug2) : BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0002396 Voltage-dependent calcium channel subunit alpha-2/delta-2 (-1) BE0002355 Voltage-dependent L-type calcium channel subunit alpha-1S (-1) BE0000679 Voltage-dependent calcium channel gamma-1 subunit (-1) --------------------------------------------------- Drug1 : DB00622 Nicardipine Drug2 : DB01115 Nifedipine Pharmacological target (-,-) : BE0000430 Voltage-dependent L-type calcium channel subunit alpha-1C Pharmacological target (-,-) : BE0000691 Voltage-dependent calcium channel subunit alpha-2/delta-1 Pharmacological target (-,-) : BE0002354 Voltage-dependent L-type calcium channel subunit beta-2 Pharmacological target (-,-) : BE0002359 Voltage-dependent L-type calcium channel subunit alpha-1D Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0003565 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (-1) BE0003323 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (-1) Non-common off-target(s) (drug2) : BE0000781 Potassium voltage-gated channel subfamily A member 1 (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0002355 Voltage-dependent L-type calcium channel subunit alpha-1S (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00623 Fluphenazine Drug2 : DB00875 Flupentixol Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Pharmacological target (-,-) : BE0000020 D(1A) dopamine receptor Non-common off-target(s) (drug1) : BE0000418 Calmodulin (-1) Non-common off-target(s) (drug2) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB00623 Fluphenazine Drug2 : DB00933 Mesoridazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000020 D(1A) dopamine receptor (-1) BE0000418 Calmodulin (-1) Non-common off-target(s) (drug2) : BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB00623 Fluphenazine Drug2 : DB01038 Carphenazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Pharmacological target (-,-) : BE0000020 D(1A) dopamine receptor Non-common off-target(s) (drug1) : BE0000418 Calmodulin (-1) Non-common off-target(s) (drug2) : BE0000145 D(1B) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00623 Fluphenazine Drug2 : DB01063 Acetophenazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Pharmacological target (-,-) : BE0000020 D(1A) dopamine receptor Non-common off-target(s) (drug1) : BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00623 Fluphenazine Drug2 : DB01184 Domperidone Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000020 D(1A) dopamine receptor (-1) BE0000418 Calmodulin (-1) Non-common off-target(s) (drug2) : BE0000581 D(3) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00623 Fluphenazine Drug2 : DB01233 Metoclopramide Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000020 D(1A) dopamine receptor (-1) BE0000418 Calmodulin (-1) Non-common off-target(s) (drug2) : BE0000092 Muscarinic acetylcholine receptor M1 (1) BE0000311 5-hydroxytryptamine receptor 3A (1) BE0000084 5-hydroxytryptamine receptor 4 (1) --------------------------------------------------- Drug1 : DB00623 Fluphenazine Drug2 : DB01425 Alizapride Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000020 D(1A) dopamine receptor (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00623 Fluphenazine Drug2 : DB01608 Propericiazine Pharmacological target (-,-) : BE0000020 D(1A) dopamine receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000418 Calmodulin (-1) Non-common off-target(s) (drug2) : BE0000575 Alpha-1B adrenergic receptor (-1) BE0000289 Alpha-2A adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00623 Fluphenazine Drug2 : DB01614 Acepromazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Pharmacological target (-,-) : BE0000020 D(1A) dopamine receptor Non-common off-target(s) (drug1) : BE0000418 Calmodulin (-1) Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB00623 Fluphenazine Drug2 : DB01618 Molindone Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000020 D(1A) dopamine receptor (-1) BE0000418 Calmodulin (-1) Non-common off-target(s) (drug2) : BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB00623 Fluphenazine Drug2 : DB01621 Pipotiazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Pharmacological target (-,-) : BE0000020 D(1A) dopamine receptor Non-common off-target(s) (drug1) : BE0000418 Calmodulin (-1) Non-common off-target(s) (drug2) : BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB00623 Fluphenazine Drug2 : DB01623 Thiothixene Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Pharmacological target (-,-) : BE0000020 D(1A) dopamine receptor Non-common off-target(s) (drug1) : BE0000418 Calmodulin (-1) Non-common off-target(s) (drug2) : BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB00623 Fluphenazine Drug2 : DB01624 Zuclopenthixol Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Pharmacological target (-,-) : BE0000020 D(1A) dopamine receptor Non-common off-target(s) (drug1) : BE0000418 Calmodulin (-1) Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000145 D(1B) dopamine receptor (-1) BE0000289 Alpha-2A adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00623 Fluphenazine Drug2 : DB04842 Fluspirilene Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000020 D(1A) dopamine receptor (-1) BE0000418 Calmodulin (-1) Non-common off-target(s) (drug2) : BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000679 Voltage-dependent calcium channel gamma-1 subunit (-1) --------------------------------------------------- Drug1 : DB00623 Fluphenazine Drug2 : DB06288 Amisulpride Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000020 D(1A) dopamine receptor (-1) BE0000418 Calmodulin (-1) Non-common off-target(s) (drug2) : BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000581 D(3) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00623 Fluphenazine Drug2 : DB08815 Lurasidone Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000020 D(1A) dopamine receptor (-1) BE0000418 Calmodulin (-1) Non-common off-target(s) (drug2) : BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000342 Alpha-2C adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00623 Fluphenazine Drug2 : DB09018 Bromopride Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000020 D(1A) dopamine receptor (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00624 Testosterone Drug2 : DB00858 Drostanolone Pharmacological target (+,+) : BE0000132 Androgen receptor --------------------------------------------------- Drug1 : DB00624 Testosterone Drug2 : DB00984 Nandrolone phenpropionate Pharmacological target (+,+) : BE0000132 Androgen receptor --------------------------------------------------- Drug1 : DB00624 Testosterone Drug2 : DB01420 Testosterone Propionate Pharmacological target (+,+) : BE0000132 Androgen receptor --------------------------------------------------- Drug1 : DB00624 Testosterone Drug2 : DB01481 Delta1-dihydrotestosterone Pharmacological target (+,+) : BE0000132 Androgen receptor --------------------------------------------------- Drug1 : DB00624 Testosterone Drug2 : DB01541 Boldenone Pharmacological target (+,+) : BE0000132 Androgen receptor --------------------------------------------------- Drug1 : DB00624 Testosterone Drug2 : DB06710 Methyltestosterone Pharmacological target (+,+) : BE0000132 Androgen receptor --------------------------------------------------- Drug1 : DB00624 Testosterone Drug2 : DB08804 Nandrolone decanoate Pharmacological target (+,+) : BE0000132 Androgen receptor --------------------------------------------------- Drug1 : DB00628 Clorazepate Drug2 : DB01068 Clonazepam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0000736 Translocator protein (1) --------------------------------------------------- Drug1 : DB00628 Clorazepate Drug2 : DB01107 Methyprylon Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0000736 Translocator protein (1) Non-common off-target(s) (drug2) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) --------------------------------------------------- Drug1 : DB00628 Clorazepate Drug2 : DB01159 Halothane Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0000736 Translocator protein (1) Non-common off-target(s) (drug2) : BE0000534 Glutamate receptor ionotropic, NMDA 3B (-1) BE0000760 Glutamate receptor ionotropic, NMDA 2A (-1) BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000503 NADH-ubiquinone oxidoreductase chain 1 (-1) BE0000415 Intermediate conductance calcium-activated potassium channel protein 4 (-1) BE0000553 Calcium-activated potassium channel subunit alpha-1 (-1) BE0001028 G protein-activated inward rectifier potassium channel 1 (-1) BE0001030 G protein-activated inward rectifier potassium channel 2 (-1) --------------------------------------------------- Drug1 : DB00628 Clorazepate Drug2 : DB01437 Glutethimide Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0000736 Translocator protein (1) Non-common off-target(s) (drug2) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) --------------------------------------------------- Drug1 : DB00629 Guanabenz Drug2 : DB00633 Dexmedetomidine Pharmacological target (+,+) : BE0000289 Alpha-2A adrenergic receptor --------------------------------------------------- Drug1 : DB00629 Guanabenz Drug2 : DB00935 Oxymetazoline Pharmacological target (+,+) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00629 Guanabenz Drug2 : DB00964 Apraclonidine Pharmacological target (+,+) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00629 Guanabenz Drug2 : DB01018 Guanfacine Pharmacological target (+,+) : BE0000289 Alpha-2A adrenergic receptor --------------------------------------------------- Drug1 : DB00629 Guanabenz Drug2 : DB04948 Lofexidine Pharmacological target (+,+) : BE0000289 Alpha-2A adrenergic receptor --------------------------------------------------- Drug1 : DB00629 Guanabenz Drug2 : DB06711 Naphazoline Pharmacological target (+,+) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00630 Alendronate Drug2 : DB00710 Ibandronate Pharmacological target (-,-) : BE0000776 Farnesyl pyrophosphate synthase Pharmacological target (-,-) : BE0004801 Hydroxylapatite Non-common off-target(s) (drug1) : BE0000980 Tyrosine-protein phosphatase non-receptor type 4 (-1) BE0003567 Receptor-type tyrosine-protein phosphatase S (-1) BE0003568 Receptor-type tyrosine-protein phosphatase epsilon (-1) BE0003569 V-type proton ATPase catalytic subunit A (-1) --------------------------------------------------- Drug1 : DB00630 Alendronate Drug2 : DB00884 Risedronate Pharmacological target (-,-) : BE0000776 Farnesyl pyrophosphate synthase Pharmacological target (-,-) : BE0004801 Hydroxylapatite Non-common off-target(s) (drug1) : BE0000980 Tyrosine-protein phosphatase non-receptor type 4 (-1) BE0003567 Receptor-type tyrosine-protein phosphatase S (-1) BE0003568 Receptor-type tyrosine-protein phosphatase epsilon (-1) BE0003569 V-type proton ATPase catalytic subunit A (-1) --------------------------------------------------- Drug1 : DB00631 Clofarabine Drug2 : DB01005 Hydroxyurea Pharmacological target (-,-) : BE0000325 Ribonucleoside-diphosphate reductase large subunit Non-common off-target(s) (drug1) : BE0000546 DNA polymerase alpha catalytic subunit (-1) --------------------------------------------------- Drug1 : DB00631 Clofarabine Drug2 : DB01073 Fludarabine Pharmacological target (-,-) : BE0000325 Ribonucleoside-diphosphate reductase large subunit Pharmacological target (-,-) : BE0000546 DNA polymerase alpha catalytic subunit Non-common off-target(s) (drug2) : BE0002804 Deoxycytidine kinase (1) --------------------------------------------------- Drug1 : DB00633 Dexmedetomidine Drug2 : DB00935 Oxymetazoline Pharmacological target (+,+) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00633 Dexmedetomidine Drug2 : DB00964 Apraclonidine Pharmacological target (+,+) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00633 Dexmedetomidine Drug2 : DB01018 Guanfacine Pharmacological target (+,+) : BE0000289 Alpha-2A adrenergic receptor --------------------------------------------------- Drug1 : DB00633 Dexmedetomidine Drug2 : DB04948 Lofexidine Pharmacological target (+,+) : BE0000289 Alpha-2A adrenergic receptor --------------------------------------------------- Drug1 : DB00633 Dexmedetomidine Drug2 : DB06711 Naphazoline Pharmacological target (+,+) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00635 Prednisone Drug2 : DB00663 Flumethasone Pivalate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00635 Prednisone Drug2 : DB00741 Hydrocortisone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug2) : BE0000422 Annexin A1 (1) --------------------------------------------------- Drug1 : DB00635 Prednisone Drug2 : DB00764 Mometasone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00635 Prednisone Drug2 : DB00769 Hydrocortamate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00635 Prednisone Drug2 : DB00838 Clocortolone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00635 Prednisone Drug2 : DB00846 Flurandrenolide Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00635 Prednisone Drug2 : DB00860 Prednisolone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00635 Prednisone Drug2 : DB00873 Loteprednol Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00635 Prednisone Drug2 : DB00896 Rimexolone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00635 Prednisone Drug2 : DB00959 Methylprednisolone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00635 Prednisone Drug2 : DB01013 Clobetasol propionate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00635 Prednisone Drug2 : DB01047 Fluocinonide Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug2) : BE0004659 Smoothened homolog (1) --------------------------------------------------- Drug1 : DB00635 Prednisone Drug2 : DB01130 Prednicarbate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00635 Prednisone Drug2 : DB01234 Dexamethasone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug2) : BE0000005 Nitric oxide synthase, inducible (-1) BE0000422 Annexin A1 (1) BE0000074 Nuclear receptor subfamily 0 group B member 1 (1) --------------------------------------------------- Drug1 : DB00635 Prednisone Drug2 : DB01260 Desonide Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00635 Prednisone Drug2 : DB01380 Cortisone acetate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00635 Prednisone Drug2 : DB01384 Paramethasone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00635 Prednisone Drug2 : DB01410 Ciclesonide Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00635 Prednisone Drug2 : DB06781 Difluprednate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00635 Prednisone Drug2 : DB08906 Fluticasone furoate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00636 Clofibrate Drug2 : DB01039 Fenofibrate Pharmacological target (+,+) : BE0000071 Peroxisome proliferator-activated receptor alpha Non-common off-target(s) (drug2) : BE0001020 Metalloproteinase (-1) --------------------------------------------------- Drug1 : DB00636 Clofibrate Drug2 : DB01241 Gemfibrozil Pharmacological target (+,+) : BE0000071 Peroxisome proliferator-activated receptor alpha --------------------------------------------------- Drug1 : DB00636 Clofibrate Drug2 : DB08915 Aleglitazar Pharmacological target (+,+) : BE0000071 Peroxisome proliferator-activated receptor alpha Non-common off-target(s) (drug2) : BE0000215 Peroxisome proliferator-activated receptor gamma (1) --------------------------------------------------- Drug1 : DB00637 Astemizole Drug2 : DB00719 Azatadine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) --------------------------------------------------- Drug1 : DB00637 Astemizole Drug2 : DB00737 Meclizine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) --------------------------------------------------- Drug1 : DB00637 Astemizole Drug2 : DB00748 Carbinoxamine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) --------------------------------------------------- Drug1 : DB00637 Astemizole Drug2 : DB00751 Epinastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) Non-common off-target(s) (drug2) : BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000112 Histamine H2 receptor (-1) --------------------------------------------------- Drug1 : DB00637 Astemizole Drug2 : DB00768 Olopatadine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) Non-common off-target(s) (drug2) : BE0001090 Protein S100-A1 (-1) BE0001206 Protein S100-A12 (-1) BE0003602 Protein S100-A2 (-1) --------------------------------------------------- Drug1 : DB00637 Astemizole Drug2 : DB00777 Propiomazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00637 Astemizole Drug2 : DB00792 Tripelennamine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) --------------------------------------------------- Drug1 : DB00637 Astemizole Drug2 : DB00835 Brompheniramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00637 Astemizole Drug2 : DB00902 Methdilazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) --------------------------------------------------- Drug1 : DB00637 Astemizole Drug2 : DB00950 Fexofenadine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) --------------------------------------------------- Drug1 : DB00637 Astemizole Drug2 : DB00967 Desloratadine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) --------------------------------------------------- Drug1 : DB00637 Astemizole Drug2 : DB00972 Azelastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) --------------------------------------------------- Drug1 : DB00637 Astemizole Drug2 : DB00985 Dimenhydrinate Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) --------------------------------------------------- Drug1 : DB00637 Astemizole Drug2 : DB01069 Promethazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00637 Astemizole Drug2 : DB01071 Mequitazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) --------------------------------------------------- Drug1 : DB00637 Astemizole Drug2 : DB01075 Diphenhydramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) --------------------------------------------------- Drug1 : DB00637 Astemizole Drug2 : DB01084 Emedastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) --------------------------------------------------- Drug1 : DB00637 Astemizole Drug2 : DB01106 Levocabastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) Non-common off-target(s) (drug2) : BE0000464 Neurotensin receptor type 2 (-1) --------------------------------------------------- Drug1 : DB00637 Astemizole Drug2 : DB01114 Chlorphenamine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB00637 Astemizole Drug2 : DB01146 Diphenylpyraline Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB00637 Astemizole Drug2 : DB01176 Cyclizine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) Non-common off-target(s) (drug2) : BE0000951 Estrogen sulfotransferase (-1) --------------------------------------------------- Drug1 : DB00637 Astemizole Drug2 : DB01237 Bromodiphenhydramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) --------------------------------------------------- Drug1 : DB00637 Astemizole Drug2 : DB01246 Alimemazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) --------------------------------------------------- Drug1 : DB00637 Astemizole Drug2 : DB01615 Aceprometazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) --------------------------------------------------- Drug1 : DB00637 Astemizole Drug2 : DB01619 Phenindamine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) --------------------------------------------------- Drug1 : DB00637 Astemizole Drug2 : DB01620 Pheniramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) --------------------------------------------------- Drug1 : DB00637 Astemizole Drug2 : DB04837 Clofedanol Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) --------------------------------------------------- Drug1 : DB00637 Astemizole Drug2 : DB04890 Bepotastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) --------------------------------------------------- Drug1 : DB00637 Astemizole Drug2 : DB06691 Mepyramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) --------------------------------------------------- Drug1 : DB00637 Astemizole Drug2 : DB08799 Antazoline Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) --------------------------------------------------- Drug1 : DB00637 Astemizole Drug2 : DB08800 Chloropyramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) --------------------------------------------------- Drug1 : DB00637 Astemizole Drug2 : DB08801 Dimetindene Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) Non-common off-target(s) (drug2) : BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00637 Astemizole Drug2 : DB08802 Isothipendyl Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) --------------------------------------------------- Drug1 : DB00637 Astemizole Drug2 : DB08936 Chlorcyclizine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) --------------------------------------------------- Drug1 : DB00641 Simvastatin Drug2 : DB01076 Atorvastatin Pharmacological target (-,-) : BE0000574 3-hydroxy-3-methylglutaryl-coenzyme A reductase Non-common off-target(s) (drug2) : BE0003721 Aryl hydrocarbon receptor (1) BE0000854 Dipeptidyl peptidase 4 (-1) --------------------------------------------------- Drug1 : DB00641 Simvastatin Drug2 : DB01095 Fluvastatin Pharmacological target (-,-) : BE0000574 3-hydroxy-3-methylglutaryl-coenzyme A reductase --------------------------------------------------- Drug1 : DB00641 Simvastatin Drug2 : DB01098 Rosuvastatin Pharmacological target (-,-) : BE0000574 3-hydroxy-3-methylglutaryl-coenzyme A reductase --------------------------------------------------- Drug1 : DB00641 Simvastatin Drug2 : DB06693 Mevastatin Pharmacological target (-,-) : BE0000574 3-hydroxy-3-methylglutaryl-coenzyme A reductase --------------------------------------------------- Drug1 : DB00641 Simvastatin Drug2 : DB08860 Pitavastatin Pharmacological target (-,-) : BE0000574 3-hydroxy-3-methylglutaryl-coenzyme A reductase --------------------------------------------------- Drug1 : DB00642 Pemetrexed Drug2 : DB06813 Pralatrexate Pharmacological target (-,-) : BE0000330 Dihydrofolate reductase Pharmacological target (-,-) : BE0000324 Thymidylate synthase Non-common off-target(s) (drug1) : BE0001240 Bifunctional purine biosynthesis protein PURH (-1) BE0000882 Trifunctional purine biosynthetic protein adenosine-3 (-1) --------------------------------------------------- Drug1 : DB00644 Gonadorelin Drug2 : DB00666 Nafarelin Pharmacological target (+,+) : BE0000203 Gonadotropin-releasing hormone receptor Pharmacological target (+,+) : BE0000472 Putative gonadotropin-releasing hormone II receptor --------------------------------------------------- Drug1 : DB00645 Dyclonine Drug2 : DB00807 Proparacaine Pharmacological target (-,-) : BE0000177 Sodium channel protein type 10 subunit alpha --------------------------------------------------- Drug1 : DB00645 Dyclonine Drug2 : DB00892 Oxybuprocaine Pharmacological target (-,-) : BE0000177 Sodium channel protein type 10 subunit alpha --------------------------------------------------- Drug1 : DB00645 Dyclonine Drug2 : DB00961 Mepivacaine Pharmacological target (-,-) : BE0000177 Sodium channel protein type 10 subunit alpha --------------------------------------------------- Drug1 : DB00645 Dyclonine Drug2 : DB01002 Levobupivacaine Pharmacological target (-,-) : BE0000177 Sodium channel protein type 10 subunit alpha --------------------------------------------------- Drug1 : DB00645 Dyclonine Drug2 : DB01086 Benzocaine Pharmacological target (-,-) : BE0000177 Sodium channel protein type 10 subunit alpha --------------------------------------------------- Drug1 : DB00645 Dyclonine Drug2 : DB01161 Chloroprocaine Pharmacological target (-,-) : BE0000177 Sodium channel protein type 10 subunit alpha Non-common off-target(s) (drug2) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000411 Neuronal acetylcholine receptor subunit alpha-10 (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) --------------------------------------------------- Drug1 : DB00647 Dextropropoxyphene Drug2 : DB00956 Hydrocodone Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Pharmacological target (+,+) : BE0000420 Delta-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (-1) --------------------------------------------------- Drug1 : DB00647 Dextropropoxyphene Drug2 : DB01209 Dezocine Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Pharmacological target (-,-) : BE0000632 Kappa-type opioid receptor Non-common off-target(s) (drug1) : BE0000420 Delta-type opioid receptor (1) --------------------------------------------------- Drug1 : DB00650 Leucovorin Drug2 : DB01101 Capecitabine Pharmacological target (-,-) : BE0000324 Thymidylate synthase --------------------------------------------------- Drug1 : DB00650 Leucovorin Drug2 : DB06813 Pralatrexate Pharmacological target (-,-) : BE0000324 Thymidylate synthase Non-common off-target(s) (drug2) : BE0000330 Dihydrofolate reductase (-1) --------------------------------------------------- Drug1 : DB00651 Dyphylline Drug2 : DB00806 Pentoxifylline Pharmacological target (-,-) : BE0000487 cAMP-specific 3',5'-cyclic phosphodiesterase 4B Pharmacological target (-,-) : BE0000013 Adenosine receptor A1 Pharmacological target (-,-) : BE0000924 Adenosine receptor A2a Pharmacological target (-,-) : BE0001133 cAMP-specific 3',5'-cyclic phosphodiesterase 4A Non-common off-target(s) (drug1) : BE0001287 cAMP-specific 3',5'-cyclic phosphodiesterase 4D (-1) BE0002353 cAMP-specific 3',5'-cyclic phosphodiesterase 4C (-1) BE0000706 High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (-1) BE0000627 cAMP-specific 3',5'-cyclic phosphodiesterase 7B (-1) Non-common off-target(s) (drug2) : BE0000182 cGMP-specific 3',5'-cyclic phosphodiesterase (-1) BE0001096 5'-nucleotidase (-1) --------------------------------------------------- Drug1 : DB00651 Dyphylline Drug2 : DB00920 Ketotifen Pharmacological target (-,-) : BE0000487 cAMP-specific 3',5'-cyclic phosphodiesterase 4B Pharmacological target (-,-) : BE0001287 cAMP-specific 3',5'-cyclic phosphodiesterase 4D Pharmacological target (-,-) : BE0001133 cAMP-specific 3',5'-cyclic phosphodiesterase 4A Pharmacological target (-,-) : BE0002353 cAMP-specific 3',5'-cyclic phosphodiesterase 4C Pharmacological target (-,-) : BE0000706 High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A Pharmacological target (-,-) : BE0000627 cAMP-specific 3',5'-cyclic phosphodiesterase 7B Non-common off-target(s) (drug1) : BE0000013 Adenosine receptor A1 (-1) BE0000924 Adenosine receptor A2a (-1) Non-common off-target(s) (drug2) : BE0000442 Histamine H1 receptor (-1) BE0003559 6-phosphogluconate dehydrogenase, decarboxylating (-1) BE0003717 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (-1) BE0003718 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (-1) --------------------------------------------------- Drug1 : DB00652 Pentazocine Drug2 : DB00844 Nalbuphine Pharmacological target (+,+) : BE0000632 Kappa-type opioid receptor Pharmacological target (-,-) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000156 Sigma non-opioid intracellular receptor 1 (1) Non-common off-target(s) (drug2) : BE0000420 Delta-type opioid receptor (-1) --------------------------------------------------- Drug1 : DB00654 Latanoprost Drug2 : DB01160 Dinoprost Tromethamine Pharmacological target (+,+) : BE0000610 Prostaglandin F2-alpha receptor Non-common off-target(s) (drug2) : BE0000475 Prostacyclin receptor (-1) --------------------------------------------------- Drug1 : DB00654 Latanoprost Drug2 : DB08819 Tafluprost Pharmacological target (+,+) : BE0000610 Prostaglandin F2-alpha receptor --------------------------------------------------- Drug1 : DB00655 Estrone Drug2 : DB00783 Estradiol Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug2) : BE0000792 Estrogen receptor beta (1) --------------------------------------------------- Drug1 : DB00655 Estrone Drug2 : DB00823 Ethynodiol Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug2) : BE0000557 Progesterone receptor (1) --------------------------------------------------- Drug1 : DB00655 Estrone Drug2 : DB00890 Dienestrol Pharmacological target (+,+) : BE0000123 Estrogen receptor --------------------------------------------------- Drug1 : DB00655 Estrone Drug2 : DB00957 Norgestimate Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug2) : BE0000557 Progesterone receptor (1) --------------------------------------------------- Drug1 : DB00655 Estrone Drug2 : DB00977 Ethinyl Estradiol Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug2) : BE0000956 Nuclear receptor subfamily 1 group I member 2 (1) --------------------------------------------------- Drug1 : DB00655 Estrone Drug2 : DB01357 Mestranol Pharmacological target (+,+) : BE0000123 Estrogen receptor --------------------------------------------------- Drug1 : DB00655 Estrone Drug2 : DB04573 Estriol Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug2) : BE0000792 Estrogen receptor beta (1) --------------------------------------------------- Drug1 : DB00655 Estrone Drug2 : DB04574 Estropipate Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug2) : BE0000792 Estrogen receptor beta (1) --------------------------------------------------- Drug1 : DB00655 Estrone Drug2 : DB04575 Quinestrol Pharmacological target (+,+) : BE0000123 Estrogen receptor --------------------------------------------------- Drug1 : DB00656 Trazodone Drug2 : DB08810 Cinitapride Pharmacological target (+,+) : BE0000291 5-hydroxytryptamine receptor 1A Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000533 5-hydroxytryptamine receptor 2C (1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000289 Alpha-2A adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000084 5-hydroxytryptamine receptor 4 (1) --------------------------------------------------- Drug1 : DB00657 Mecamylamine Drug2 : DB00728 Rocuronium Pharmacological target (-,-) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 Non-common off-target(s) (drug2) : BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) --------------------------------------------------- Drug1 : DB00657 Mecamylamine Drug2 : DB00732 Atracurium Pharmacological target (-,-) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 --------------------------------------------------- Drug1 : DB00657 Mecamylamine Drug2 : DB00810 Biperiden Pharmacological target (-,-) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 Non-common off-target(s) (drug2) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) --------------------------------------------------- Drug1 : DB00657 Mecamylamine Drug2 : DB01135 Doxacurium chloride Pharmacological target (-,-) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 Non-common off-target(s) (drug2) : BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00657 Mecamylamine Drug2 : DB01199 Tubocurarine Pharmacological target (-,-) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 Non-common off-target(s) (drug2) : BE0000426 Acetylcholinesterase (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) --------------------------------------------------- Drug1 : DB00657 Mecamylamine Drug2 : DB01226 Mivacurium Pharmacological target (-,-) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) --------------------------------------------------- Drug1 : DB00657 Mecamylamine Drug2 : DB01336 Metocurine Pharmacological target (-,-) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 Non-common off-target(s) (drug2) : BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00657 Mecamylamine Drug2 : DB01337 Pancuronium Pharmacological target (-,-) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00657 Mecamylamine Drug2 : DB01338 Pipecuronium Pharmacological target (-,-) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00657 Mecamylamine Drug2 : DB01339 Vecuronium Pharmacological target (-,-) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 --------------------------------------------------- Drug1 : DB00661 Verapamil Drug2 : DB01023 Felodipine Pharmacological target (-,-) : BE0000430 Voltage-dependent L-type calcium channel subunit alpha-1C Pharmacological target (-,-) : BE0002354 Voltage-dependent L-type calcium channel subunit beta-2 Pharmacological target (-,-) : BE0002359 Voltage-dependent L-type calcium channel subunit alpha-1D Pharmacological target (-,-) : BE0002355 Voltage-dependent L-type calcium channel subunit alpha-1S Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000708 ATP-sensitive inward rectifier potassium channel 11 (-1) BE0000356 Voltage-dependent P/Q-type calcium channel subunit alpha-1A (-1) BE0000303 Voltage-dependent L-type calcium channel subunit beta-1 (-1) BE0000483 Voltage-dependent T-type calcium channel subunit alpha-1G (-1) BE0002226 Voltage-dependent N-type calcium channel subunit alpha-1B (-1) BE0002357 Voltage-dependent L-type calcium channel subunit alpha-1F (-1) BE0002358 Voltage-dependent L-type calcium channel subunit beta-3 (-1) BE0002356 Voltage-dependent L-type calcium channel subunit beta-4 (-1) BE0000012 Voltage-dependent T-type calcium channel subunit alpha-1I (-1) Non-common off-target(s) (drug2) : BE0000691 Voltage-dependent calcium channel subunit alpha-2/delta-1 (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0002396 Voltage-dependent calcium channel subunit alpha-2/delta-2 (-1) BE0000668 Mineralocorticoid receptor (-1) BE0003565 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (-1) BE0003323 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (-1) --------------------------------------------------- Drug1 : DB00661 Verapamil Drug2 : DB01054 Nitrendipine Pharmacological target (-,-) : BE0000430 Voltage-dependent L-type calcium channel subunit alpha-1C Pharmacological target (-,-) : BE0002354 Voltage-dependent L-type calcium channel subunit beta-2 Pharmacological target (-,-) : BE0002359 Voltage-dependent L-type calcium channel subunit alpha-1D Pharmacological target (-,-) : BE0002355 Voltage-dependent L-type calcium channel subunit alpha-1S Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000708 ATP-sensitive inward rectifier potassium channel 11 (-1) BE0000356 Voltage-dependent P/Q-type calcium channel subunit alpha-1A (-1) BE0000303 Voltage-dependent L-type calcium channel subunit beta-1 (-1) BE0000483 Voltage-dependent T-type calcium channel subunit alpha-1G (-1) BE0002226 Voltage-dependent N-type calcium channel subunit alpha-1B (-1) BE0002357 Voltage-dependent L-type calcium channel subunit alpha-1F (-1) BE0002358 Voltage-dependent L-type calcium channel subunit beta-3 (-1) BE0002356 Voltage-dependent L-type calcium channel subunit beta-4 (-1) BE0000012 Voltage-dependent T-type calcium channel subunit alpha-1I (-1) Non-common off-target(s) (drug2) : BE0000691 Voltage-dependent calcium channel subunit alpha-2/delta-1 (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0002396 Voltage-dependent calcium channel subunit alpha-2/delta-2 (-1) BE0000679 Voltage-dependent calcium channel gamma-1 subunit (-1) --------------------------------------------------- Drug1 : DB00661 Verapamil Drug2 : DB01115 Nifedipine Pharmacological target (-,-) : BE0000430 Voltage-dependent L-type calcium channel subunit alpha-1C Pharmacological target (-,-) : BE0002354 Voltage-dependent L-type calcium channel subunit beta-2 Pharmacological target (-,-) : BE0002359 Voltage-dependent L-type calcium channel subunit alpha-1D Pharmacological target (-,-) : BE0002355 Voltage-dependent L-type calcium channel subunit alpha-1S Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000708 ATP-sensitive inward rectifier potassium channel 11 (-1) BE0000356 Voltage-dependent P/Q-type calcium channel subunit alpha-1A (-1) BE0000303 Voltage-dependent L-type calcium channel subunit beta-1 (-1) BE0000483 Voltage-dependent T-type calcium channel subunit alpha-1G (-1) BE0002226 Voltage-dependent N-type calcium channel subunit alpha-1B (-1) BE0002357 Voltage-dependent L-type calcium channel subunit alpha-1F (-1) BE0002358 Voltage-dependent L-type calcium channel subunit beta-3 (-1) BE0002356 Voltage-dependent L-type calcium channel subunit beta-4 (-1) BE0000012 Voltage-dependent T-type calcium channel subunit alpha-1I (-1) Non-common off-target(s) (drug2) : BE0000781 Potassium voltage-gated channel subfamily A member 1 (-1) BE0000691 Voltage-dependent calcium channel subunit alpha-2/delta-1 (-1) BE0000864 Voltage-dependent T-type calcium channel subunit alpha-1H (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00663 Flumethasone Pivalate Drug2 : DB00741 Hydrocortisone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug2) : BE0000422 Annexin A1 (1) --------------------------------------------------- Drug1 : DB00663 Flumethasone Pivalate Drug2 : DB00764 Mometasone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00663 Flumethasone Pivalate Drug2 : DB00769 Hydrocortamate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00663 Flumethasone Pivalate Drug2 : DB00838 Clocortolone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00663 Flumethasone Pivalate Drug2 : DB00846 Flurandrenolide Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00663 Flumethasone Pivalate Drug2 : DB00860 Prednisolone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00663 Flumethasone Pivalate Drug2 : DB00873 Loteprednol Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00663 Flumethasone Pivalate Drug2 : DB00896 Rimexolone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00663 Flumethasone Pivalate Drug2 : DB00959 Methylprednisolone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00663 Flumethasone Pivalate Drug2 : DB01013 Clobetasol propionate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00663 Flumethasone Pivalate Drug2 : DB01047 Fluocinonide Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug2) : BE0004659 Smoothened homolog (1) --------------------------------------------------- Drug1 : DB00663 Flumethasone Pivalate Drug2 : DB01130 Prednicarbate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00663 Flumethasone Pivalate Drug2 : DB01234 Dexamethasone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug2) : BE0000005 Nitric oxide synthase, inducible (-1) BE0000422 Annexin A1 (1) BE0000074 Nuclear receptor subfamily 0 group B member 1 (1) --------------------------------------------------- Drug1 : DB00663 Flumethasone Pivalate Drug2 : DB01260 Desonide Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00663 Flumethasone Pivalate Drug2 : DB01380 Cortisone acetate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00663 Flumethasone Pivalate Drug2 : DB01384 Paramethasone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00663 Flumethasone Pivalate Drug2 : DB01410 Ciclesonide Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00663 Flumethasone Pivalate Drug2 : DB06781 Difluprednate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00663 Flumethasone Pivalate Drug2 : DB08906 Fluticasone furoate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00665 Nilutamide Drug2 : DB01128 Bicalutamide Pharmacological target (-,-) : BE0000132 Androgen receptor --------------------------------------------------- Drug1 : DB00665 Nilutamide Drug2 : DB04839 Cyproterone acetate Pharmacological target (-,-) : BE0000132 Androgen receptor --------------------------------------------------- Drug1 : DB00665 Nilutamide Drug2 : DB08899 Enzalutamide Pharmacological target (-,-) : BE0000132 Androgen receptor --------------------------------------------------- Drug1 : DB00669 Sumatriptan Drug2 : DB00952 Naratriptan Pharmacological target (+,+) : BE0000659 5-hydroxytryptamine receptor 1D Pharmacological target (+,+) : BE0000797 5-hydroxytryptamine receptor 1B Pharmacological target (+,+) : BE0000460 5-hydroxytryptamine receptor 1F Pharmacological target (+,+) : BE0000291 5-hydroxytryptamine receptor 1A --------------------------------------------------- Drug1 : DB00669 Sumatriptan Drug2 : DB00953 Rizatriptan Pharmacological target (+,+) : BE0000659 5-hydroxytryptamine receptor 1D Pharmacological target (+,+) : BE0000797 5-hydroxytryptamine receptor 1B Pharmacological target (+,+) : BE0000460 5-hydroxytryptamine receptor 1F Non-common off-target(s) (drug1) : BE0000291 5-hydroxytryptamine receptor 1A (1) --------------------------------------------------- Drug1 : DB00669 Sumatriptan Drug2 : DB00998 Frovatriptan Pharmacological target (+,+) : BE0000659 5-hydroxytryptamine receptor 1D Pharmacological target (+,+) : BE0000797 5-hydroxytryptamine receptor 1B Non-common off-target(s) (drug1) : BE0000460 5-hydroxytryptamine receptor 1F (1) BE0000291 5-hydroxytryptamine receptor 1A (1) --------------------------------------------------- Drug1 : DB00670 Pirenzepine Drug2 : DB00747 Scopolamine Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0001176 Sucrase-isomaltase, intestinal (-1) --------------------------------------------------- Drug1 : DB00670 Pirenzepine Drug2 : DB00771 Clidinium Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 --------------------------------------------------- Drug1 : DB00670 Pirenzepine Drug2 : DB00782 Propantheline Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 --------------------------------------------------- Drug1 : DB00670 Pirenzepine Drug2 : DB00804 Dicyclomine Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug2) : BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00670 Pirenzepine Drug2 : DB00810 Biperiden Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug2) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) --------------------------------------------------- Drug1 : DB00670 Pirenzepine Drug2 : DB00942 Cycrimine Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 --------------------------------------------------- Drug1 : DB00670 Pirenzepine Drug2 : DB00979 Cyclopentolate Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 --------------------------------------------------- Drug1 : DB00670 Pirenzepine Drug2 : DB00986 Glycopyrrolate Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) --------------------------------------------------- Drug1 : DB00670 Pirenzepine Drug2 : DB01148 Flavoxate Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug2) : BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00670 Pirenzepine Drug2 : DB04843 Mepenzolate Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) --------------------------------------------------- Drug1 : DB00672 Chlorpropamide Drug2 : DB00731 Nateglinide Pharmacological target (-,-) : BE0000207 ATP-binding cassette sub-family C member 8 Non-common off-target(s) (drug2) : BE0000215 Peroxisome proliferator-activated receptor gamma (1) --------------------------------------------------- Drug1 : DB00672 Chlorpropamide Drug2 : DB00912 Repaglinide Pharmacological target (-,-) : BE0000207 ATP-binding cassette sub-family C member 8 Non-common off-target(s) (drug2) : BE0000215 Peroxisome proliferator-activated receptor gamma (1) --------------------------------------------------- Drug1 : DB00672 Chlorpropamide Drug2 : DB01067 Glipizide Pharmacological target (-,-) : BE0000207 ATP-binding cassette sub-family C member 8 Non-common off-target(s) (drug2) : BE0000215 Peroxisome proliferator-activated receptor gamma (1) --------------------------------------------------- Drug1 : DB00672 Chlorpropamide Drug2 : DB01124 Tolbutamide Pharmacological target (-,-) : BE0000207 ATP-binding cassette sub-family C member 8 Non-common off-target(s) (drug2) : BE0000644 ATP-sensitive inward rectifier potassium channel 1 (-1) --------------------------------------------------- Drug1 : DB00672 Chlorpropamide Drug2 : DB01251 Gliquidone Pharmacological target (-,-) : BE0000207 ATP-binding cassette sub-family C member 8 Non-common off-target(s) (drug2) : BE0002441 ATP-sensitive inward rectifier potassium channel 8 (-1) --------------------------------------------------- Drug1 : DB00672 Chlorpropamide Drug2 : DB01252 Mitiglinide Pharmacological target (-,-) : BE0000207 ATP-binding cassette sub-family C member 8 Non-common off-target(s) (drug2) : BE0000215 Peroxisome proliferator-activated receptor gamma (1) --------------------------------------------------- Drug1 : DB00673 Aprepitant Drug2 : DB09048 Netupitant Pharmacological target (-,-) : BE0000384 Substance-P receptor --------------------------------------------------- Drug1 : DB00674 Galantamine Drug2 : DB00843 Donepezil Pharmacological target (-,-) : BE0000426 Acetylcholinesterase Non-common off-target(s) (drug1) : BE0002180 Cholinesterase (-1) --------------------------------------------------- Drug1 : DB00674 Galantamine Drug2 : DB00981 Physostigmine Pharmacological target (-,-) : BE0000426 Acetylcholinesterase Non-common off-target(s) (drug1) : BE0002180 Cholinesterase (-1) --------------------------------------------------- Drug1 : DB00674 Galantamine Drug2 : DB01122 Ambenonium Pharmacological target (-,-) : BE0000426 Acetylcholinesterase Non-common off-target(s) (drug1) : BE0002180 Cholinesterase (-1) --------------------------------------------------- Drug1 : DB00674 Galantamine Drug2 : DB01400 Neostigmine Pharmacological target (-,-) : BE0000426 Acetylcholinesterase Non-common off-target(s) (drug1) : BE0002180 Cholinesterase (-1) --------------------------------------------------- Drug1 : DB00674 Galantamine Drug2 : DB08996 Dimetacrine Pharmacological target (-,-) : BE0000426 Acetylcholinesterase Non-common off-target(s) (drug1) : BE0002180 Cholinesterase (-1) --------------------------------------------------- Drug1 : DB00677 Isoflurophate Drug2 : DB00772 Malathion Pharmacological target (-,-) : BE0002180 Cholinesterase Non-common off-target(s) (drug1) : BE0000426 Acetylcholinesterase (-1) --------------------------------------------------- Drug1 : DB00677 Isoflurophate Drug2 : DB00843 Donepezil Pharmacological target (-,-) : BE0000426 Acetylcholinesterase Non-common off-target(s) (drug1) : BE0002180 Cholinesterase (-1) --------------------------------------------------- Drug1 : DB00677 Isoflurophate Drug2 : DB00941 Hexafluronium Pharmacological target (-,-) : BE0002180 Cholinesterase Non-common off-target(s) (drug1) : BE0000426 Acetylcholinesterase (-1) --------------------------------------------------- Drug1 : DB00677 Isoflurophate Drug2 : DB00981 Physostigmine Pharmacological target (-,-) : BE0000426 Acetylcholinesterase Non-common off-target(s) (drug1) : BE0002180 Cholinesterase (-1) --------------------------------------------------- Drug1 : DB00677 Isoflurophate Drug2 : DB00989 Rivastigmine Pharmacological target (-,-) : BE0000426 Acetylcholinesterase Pharmacological target (-,-) : BE0002180 Cholinesterase --------------------------------------------------- Drug1 : DB00677 Isoflurophate Drug2 : DB01010 Edrophonium Pharmacological target (-,-) : BE0000426 Acetylcholinesterase Pharmacological target (-,-) : BE0002180 Cholinesterase --------------------------------------------------- Drug1 : DB00677 Isoflurophate Drug2 : DB01057 Echothiophate Pharmacological target (-,-) : BE0002180 Cholinesterase Non-common off-target(s) (drug1) : BE0000426 Acetylcholinesterase (-1) --------------------------------------------------- Drug1 : DB00677 Isoflurophate Drug2 : DB01122 Ambenonium Pharmacological target (-,-) : BE0000426 Acetylcholinesterase Non-common off-target(s) (drug1) : BE0002180 Cholinesterase (-1) --------------------------------------------------- Drug1 : DB00677 Isoflurophate Drug2 : DB01400 Neostigmine Pharmacological target (-,-) : BE0000426 Acetylcholinesterase Non-common off-target(s) (drug1) : BE0002180 Cholinesterase (-1) --------------------------------------------------- Drug1 : DB00677 Isoflurophate Drug2 : DB08996 Dimetacrine Pharmacological target (-,-) : BE0000426 Acetylcholinesterase Non-common off-target(s) (drug1) : BE0002180 Cholinesterase (-1) --------------------------------------------------- Drug1 : DB00678 Losartan Drug2 : DB00796 Candesartan Pharmacological target (-,-) : BE0000062 Type-1 angiotensin II receptor --------------------------------------------------- Drug1 : DB00678 Losartan Drug2 : DB00876 Eprosartan Pharmacological target (-,-) : BE0000062 Type-1 angiotensin II receptor --------------------------------------------------- Drug1 : DB00678 Losartan Drug2 : DB00966 Telmisartan Pharmacological target (-,-) : BE0000062 Type-1 angiotensin II receptor Non-common off-target(s) (drug2) : BE0000215 Peroxisome proliferator-activated receptor gamma (1) --------------------------------------------------- Drug1 : DB00678 Losartan Drug2 : DB01029 Irbesartan Pharmacological target (-,-) : BE0000062 Type-1 angiotensin II receptor --------------------------------------------------- Drug1 : DB00678 Losartan Drug2 : DB01342 Forasartan Pharmacological target (-,-) : BE0000062 Type-1 angiotensin II receptor --------------------------------------------------- Drug1 : DB00678 Losartan Drug2 : DB01347 Saprisartan Pharmacological target (-,-) : BE0000062 Type-1 angiotensin II receptor --------------------------------------------------- Drug1 : DB00678 Losartan Drug2 : DB01349 Tasosartan Pharmacological target (-,-) : BE0000062 Type-1 angiotensin II receptor Non-common off-target(s) (drug2) : BE0003426 Type-2 angiotensin II receptor (-1) --------------------------------------------------- Drug1 : DB00678 Losartan Drug2 : DB08822 Azilsartan medoxomil Pharmacological target (-,-) : BE0000062 Type-1 angiotensin II receptor --------------------------------------------------- Drug1 : DB00679 Thioridazine Drug2 : DB00875 Flupentixol Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Pharmacological target (-,-) : BE0000501 Alpha-1A adrenergic receptor Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Pharmacological target (-,-) : BE0000020 D(1A) dopamine receptor Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000575 Alpha-1B adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) --------------------------------------------------- Drug1 : DB00679 Thioridazine Drug2 : DB01239 Chlorprothixene Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Pharmacological target (-,-) : BE0000020 D(1A) dopamine receptor Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000442 Histamine H1 receptor (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000581 D(3) dopamine receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00679 Thioridazine Drug2 : DB01621 Pipotiazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Pharmacological target (-,-) : BE0000020 D(1A) dopamine receptor Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000291 5-hydroxytryptamine receptor 1A (-1) --------------------------------------------------- Drug1 : DB00679 Thioridazine Drug2 : DB01623 Thiothixene Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Pharmacological target (-,-) : BE0000020 D(1A) dopamine receptor Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00680 Moricizine Drug2 : DB00740 Riluzole Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug2) : BE0000030 Cystine/glutamate transporter (1) --------------------------------------------------- Drug1 : DB00680 Moricizine Drug2 : DB00750 Prilocaine Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha --------------------------------------------------- Drug1 : DB00680 Moricizine Drug2 : DB00754 Ethotoin Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha --------------------------------------------------- Drug1 : DB00680 Moricizine Drug2 : DB00776 Oxcarbazepine Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha --------------------------------------------------- Drug1 : DB00680 Moricizine Drug2 : DB00908 Quinidine Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug2) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000154 Potassium channel subfamily K member 1 (-1) BE0000680 Potassium channel subfamily K member 6 (-1) --------------------------------------------------- Drug1 : DB00680 Moricizine Drug2 : DB01056 Tocainide Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha --------------------------------------------------- Drug1 : DB00680 Moricizine Drug2 : DB01182 Propafenone Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug2) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) --------------------------------------------------- Drug1 : DB00680 Moricizine Drug2 : DB01195 Flecainide Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug2) : BE0002083 Sodium channel protein type 4 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00680 Moricizine Drug2 : DB01228 Encainide Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha --------------------------------------------------- Drug1 : DB00680 Moricizine Drug2 : DB01320 Fosphenytoin Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha --------------------------------------------------- Drug1 : DB00680 Moricizine Drug2 : DB01426 Ajmaline Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha --------------------------------------------------- Drug1 : DB00680 Moricizine Drug2 : DB01429 Aprindine Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug2) : BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00682 Warfarin Drug2 : DB00946 Phenprocoumon Pharmacological target (-,-) : BE0000713 Vitamin K epoxide reductase complex subunit 1 --------------------------------------------------- Drug1 : DB00682 Warfarin Drug2 : DB01418 Acenocoumarol Pharmacological target (-,-) : BE0000713 Vitamin K epoxide reductase complex subunit 1 --------------------------------------------------- Drug1 : DB00683 Midazolam Drug2 : DB00690 Flurazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Pharmacological target (+,+) : BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Pharmacological target (+,+) : BE0003596 Gamma-aminobutyric acid receptor subunit pi Pharmacological target (+,+) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Pharmacological target (+,+) : BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 Pharmacological target (+,+) : BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 Pharmacological target (+,+) : BE0003597 Gamma-aminobutyric acid receptor subunit theta --------------------------------------------------- Drug1 : DB00683 Midazolam Drug2 : DB00801 Halazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Pharmacological target (+,+) : BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Pharmacological target (+,+) : BE0003596 Gamma-aminobutyric acid receptor subunit pi Pharmacological target (+,+) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Pharmacological target (+,+) : BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 Pharmacological target (+,+) : BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 Non-common off-target(s) (drug1) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) --------------------------------------------------- Drug1 : DB00683 Midazolam Drug2 : DB00829 Diazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Pharmacological target (+,+) : BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Pharmacological target (+,+) : BE0003596 Gamma-aminobutyric acid receptor subunit pi Pharmacological target (+,+) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Pharmacological target (+,+) : BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 Pharmacological target (+,+) : BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 Pharmacological target (+,+) : BE0003597 Gamma-aminobutyric acid receptor subunit theta Non-common off-target(s) (drug1) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) BE0000736 Translocator protein (1) --------------------------------------------------- Drug1 : DB00683 Midazolam Drug2 : DB00842 Oxazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Pharmacological target (+,+) : BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Pharmacological target (+,+) : BE0003596 Gamma-aminobutyric acid receptor subunit pi Pharmacological target (+,+) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Pharmacological target (+,+) : BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 Pharmacological target (+,+) : BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 Pharmacological target (+,+) : BE0003597 Gamma-aminobutyric acid receptor subunit theta Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) --------------------------------------------------- Drug1 : DB00683 Midazolam Drug2 : DB00897 Triazolam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Pharmacological target (+,+) : BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Pharmacological target (+,+) : BE0003596 Gamma-aminobutyric acid receptor subunit pi Pharmacological target (+,+) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Pharmacological target (+,+) : BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 Pharmacological target (+,+) : BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 Pharmacological target (+,+) : BE0003597 Gamma-aminobutyric acid receptor subunit theta Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) --------------------------------------------------- Drug1 : DB00683 Midazolam Drug2 : DB01215 Estazolam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Pharmacological target (+,+) : BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Pharmacological target (+,+) : BE0003596 Gamma-aminobutyric acid receptor subunit pi Pharmacological target (+,+) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Pharmacological target (+,+) : BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 Pharmacological target (+,+) : BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 Non-common off-target(s) (drug1) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) --------------------------------------------------- Drug1 : DB00683 Midazolam Drug2 : DB01558 Bromazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Pharmacological target (+,+) : BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Pharmacological target (+,+) : BE0003596 Gamma-aminobutyric acid receptor subunit pi Pharmacological target (+,+) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Pharmacological target (+,+) : BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 Pharmacological target (+,+) : BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 Pharmacological target (+,+) : BE0003597 Gamma-aminobutyric acid receptor subunit theta --------------------------------------------------- Drug1 : DB00683 Midazolam Drug2 : DB01559 Clotiazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Pharmacological target (+,+) : BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Pharmacological target (+,+) : BE0003596 Gamma-aminobutyric acid receptor subunit pi Pharmacological target (+,+) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Pharmacological target (+,+) : BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 Pharmacological target (+,+) : BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 Non-common off-target(s) (drug1) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00683 Midazolam Drug2 : DB01567 Fludiazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Pharmacological target (+,+) : BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Pharmacological target (+,+) : BE0003596 Gamma-aminobutyric acid receptor subunit pi Pharmacological target (+,+) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Pharmacological target (+,+) : BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 Pharmacological target (+,+) : BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 Non-common off-target(s) (drug1) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00683 Midazolam Drug2 : DB01588 Prazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Pharmacological target (+,+) : BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Pharmacological target (+,+) : BE0003596 Gamma-aminobutyric acid receptor subunit pi Pharmacological target (+,+) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Pharmacological target (+,+) : BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 Pharmacological target (+,+) : BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 Non-common off-target(s) (drug1) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) --------------------------------------------------- Drug1 : DB00683 Midazolam Drug2 : DB01589 Quazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Pharmacological target (+,+) : BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Pharmacological target (+,+) : BE0003596 Gamma-aminobutyric acid receptor subunit pi Pharmacological target (+,+) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Pharmacological target (+,+) : BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 Pharmacological target (+,+) : BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 Non-common off-target(s) (drug1) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) --------------------------------------------------- Drug1 : DB00683 Midazolam Drug2 : DB01594 Cinolazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Pharmacological target (+,+) : BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Pharmacological target (+,+) : BE0003596 Gamma-aminobutyric acid receptor subunit pi Pharmacological target (+,+) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Pharmacological target (+,+) : BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 Pharmacological target (+,+) : BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 Non-common off-target(s) (drug1) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00683 Midazolam Drug2 : DB01595 Nitrazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Pharmacological target (+,+) : BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Pharmacological target (+,+) : BE0003596 Gamma-aminobutyric acid receptor subunit pi Pharmacological target (+,+) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Pharmacological target (+,+) : BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 Pharmacological target (+,+) : BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 Pharmacological target (+,+) : BE0003597 Gamma-aminobutyric acid receptor subunit theta --------------------------------------------------- Drug1 : DB00687 Fludrocortisone Drug2 : DB01134 Desoxycorticosterone Pivalate Pharmacological target (+,+) : BE0000668 Mineralocorticoid receptor Non-common off-target(s) (drug1) : BE0000794 Glucocorticoid receptor (1) BE0000132 Androgen receptor (1) --------------------------------------------------- Drug1 : DB00688 Mycophenolate mofetil Drug2 : DB00811 Ribavirin Pharmacological target (-,-) : BE0000761 Inosine-5'-monophosphate dehydrogenase 1 Non-common off-target(s) (drug1) : BE0000722 Inosine-5'-monophosphate dehydrogenase 2 (-1) Non-common off-target(s) (drug2) : BE0003540 Adenosine kinase (1) BE0000261 Cytosolic purine 5'-nucleotidase (1) BE0000457 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (-1) --------------------------------------------------- Drug1 : DB00688 Mycophenolate mofetil Drug2 : DB01024 Mycophenolic acid Pharmacological target (-,-) : BE0000722 Inosine-5'-monophosphate dehydrogenase 2 Pharmacological target (-,-) : BE0000761 Inosine-5'-monophosphate dehydrogenase 1 --------------------------------------------------- Drug1 : DB00690 Flurazepam Drug2 : DB00801 Halazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Pharmacological target (+,+) : BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Pharmacological target (+,+) : BE0003596 Gamma-aminobutyric acid receptor subunit pi Pharmacological target (+,+) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Pharmacological target (+,+) : BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 Pharmacological target (+,+) : BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 Non-common off-target(s) (drug1) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) --------------------------------------------------- Drug1 : DB00690 Flurazepam Drug2 : DB00829 Diazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Pharmacological target (+,+) : BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Pharmacological target (+,+) : BE0003596 Gamma-aminobutyric acid receptor subunit pi Pharmacological target (+,+) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Pharmacological target (+,+) : BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 Pharmacological target (+,+) : BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 Pharmacological target (+,+) : BE0003597 Gamma-aminobutyric acid receptor subunit theta Non-common off-target(s) (drug1) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) BE0000736 Translocator protein (1) --------------------------------------------------- Drug1 : DB00690 Flurazepam Drug2 : DB00842 Oxazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Pharmacological target (+,+) : BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Pharmacological target (+,+) : BE0003596 Gamma-aminobutyric acid receptor subunit pi Pharmacological target (+,+) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Pharmacological target (+,+) : BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 Pharmacological target (+,+) : BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 Pharmacological target (+,+) : BE0003597 Gamma-aminobutyric acid receptor subunit theta Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) --------------------------------------------------- Drug1 : DB00690 Flurazepam Drug2 : DB00897 Triazolam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Pharmacological target (+,+) : BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Pharmacological target (+,+) : BE0003596 Gamma-aminobutyric acid receptor subunit pi Pharmacological target (+,+) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Pharmacological target (+,+) : BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 Pharmacological target (+,+) : BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 Pharmacological target (+,+) : BE0003597 Gamma-aminobutyric acid receptor subunit theta Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) --------------------------------------------------- Drug1 : DB00690 Flurazepam Drug2 : DB01215 Estazolam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Pharmacological target (+,+) : BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Pharmacological target (+,+) : BE0003596 Gamma-aminobutyric acid receptor subunit pi Pharmacological target (+,+) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Pharmacological target (+,+) : BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 Pharmacological target (+,+) : BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 Non-common off-target(s) (drug1) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) --------------------------------------------------- Drug1 : DB00690 Flurazepam Drug2 : DB01558 Bromazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Pharmacological target (+,+) : BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Pharmacological target (+,+) : BE0003596 Gamma-aminobutyric acid receptor subunit pi Pharmacological target (+,+) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Pharmacological target (+,+) : BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 Pharmacological target (+,+) : BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 Pharmacological target (+,+) : BE0003597 Gamma-aminobutyric acid receptor subunit theta --------------------------------------------------- Drug1 : DB00690 Flurazepam Drug2 : DB01559 Clotiazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Pharmacological target (+,+) : BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Pharmacological target (+,+) : BE0003596 Gamma-aminobutyric acid receptor subunit pi Pharmacological target (+,+) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Pharmacological target (+,+) : BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 Pharmacological target (+,+) : BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 Non-common off-target(s) (drug1) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00690 Flurazepam Drug2 : DB01567 Fludiazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Pharmacological target (+,+) : BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Pharmacological target (+,+) : BE0003596 Gamma-aminobutyric acid receptor subunit pi Pharmacological target (+,+) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Pharmacological target (+,+) : BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 Pharmacological target (+,+) : BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 Non-common off-target(s) (drug1) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00690 Flurazepam Drug2 : DB01588 Prazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Pharmacological target (+,+) : BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Pharmacological target (+,+) : BE0003596 Gamma-aminobutyric acid receptor subunit pi Pharmacological target (+,+) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Pharmacological target (+,+) : BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 Pharmacological target (+,+) : BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 Non-common off-target(s) (drug1) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) --------------------------------------------------- Drug1 : DB00690 Flurazepam Drug2 : DB01589 Quazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Pharmacological target (+,+) : BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Pharmacological target (+,+) : BE0003596 Gamma-aminobutyric acid receptor subunit pi Pharmacological target (+,+) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Pharmacological target (+,+) : BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 Pharmacological target (+,+) : BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 Non-common off-target(s) (drug1) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) --------------------------------------------------- Drug1 : DB00690 Flurazepam Drug2 : DB01594 Cinolazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Pharmacological target (+,+) : BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Pharmacological target (+,+) : BE0003596 Gamma-aminobutyric acid receptor subunit pi Pharmacological target (+,+) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Pharmacological target (+,+) : BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 Pharmacological target (+,+) : BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 Non-common off-target(s) (drug1) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00690 Flurazepam Drug2 : DB01595 Nitrazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Pharmacological target (+,+) : BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Pharmacological target (+,+) : BE0003596 Gamma-aminobutyric acid receptor subunit pi Pharmacological target (+,+) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Pharmacological target (+,+) : BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 Pharmacological target (+,+) : BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 Pharmacological target (+,+) : BE0003597 Gamma-aminobutyric acid receptor subunit theta --------------------------------------------------- Drug1 : DB00691 Moexipril Drug2 : DB00722 Lisinopril Pharmacological target (-,-) : BE0000221 Angiotensin-converting enzyme Pharmacological target (-,-) : BE0000982 Angiotensin-converting enzyme 2 --------------------------------------------------- Drug1 : DB00691 Moexipril Drug2 : DB00790 Perindopril Pharmacological target (-,-) : BE0000221 Angiotensin-converting enzyme Non-common off-target(s) (drug1) : BE0000982 Angiotensin-converting enzyme 2 (-1) --------------------------------------------------- Drug1 : DB00691 Moexipril Drug2 : DB00881 Quinapril Pharmacological target (-,-) : BE0000221 Angiotensin-converting enzyme Non-common off-target(s) (drug1) : BE0000982 Angiotensin-converting enzyme 2 (-1) --------------------------------------------------- Drug1 : DB00691 Moexipril Drug2 : DB01180 Rescinnamine Pharmacological target (-,-) : BE0000221 Angiotensin-converting enzyme Non-common off-target(s) (drug1) : BE0000982 Angiotensin-converting enzyme 2 (-1) --------------------------------------------------- Drug1 : DB00691 Moexipril Drug2 : DB01197 Captopril Pharmacological target (-,-) : BE0000221 Angiotensin-converting enzyme Non-common off-target(s) (drug1) : BE0000982 Angiotensin-converting enzyme 2 (-1) Non-common off-target(s) (drug2) : BE0000642 72 kDa type IV collagenase (-1) BE0000058 Matrix metalloproteinase-9 (-1) --------------------------------------------------- Drug1 : DB00691 Moexipril Drug2 : DB01340 Cilazapril Pharmacological target (-,-) : BE0000221 Angiotensin-converting enzyme Non-common off-target(s) (drug1) : BE0000982 Angiotensin-converting enzyme 2 (-1) --------------------------------------------------- Drug1 : DB00691 Moexipril Drug2 : DB01348 Spirapril Pharmacological target (-,-) : BE0000221 Angiotensin-converting enzyme Non-common off-target(s) (drug1) : BE0000982 Angiotensin-converting enzyme 2 (-1) --------------------------------------------------- Drug1 : DB00692 Phentolamine Drug2 : DB00699 Nicergoline Pharmacological target (-,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000289 Alpha-2A adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00692 Phentolamine Drug2 : DB00706 Tamsulosin Pharmacological target (-,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000289 Alpha-2A adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00692 Phentolamine Drug2 : DB00925 Phenoxybenzamine Pharmacological target (-,-) : BE0000501 Alpha-1A adrenergic receptor Pharmacological target (-,-) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug2) : BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00692 Phentolamine Drug2 : DB01608 Propericiazine Pharmacological target (-,-) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0000501 Alpha-1A adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000575 Alpha-1B adrenergic receptor (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00692 Phentolamine Drug2 : DB06207 Silodosin Pharmacological target (-,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000289 Alpha-2A adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00694 Daunorubicin Drug2 : DB00997 Doxorubicin Pharmacological target (-,-) : BE0000742 DNA topoisomerase 2-alpha Non-common off-target(s) (drug1) : BE0002425 DNA topoisomerase 2-beta (-1) --------------------------------------------------- Drug1 : DB00694 Daunorubicin Drug2 : DB01137 Levofloxacin Pharmacological target (-,-) : BE0000742 DNA topoisomerase 2-alpha Non-common off-target(s) (drug1) : BE0002425 DNA topoisomerase 2-beta (-1) --------------------------------------------------- Drug1 : DB00694 Daunorubicin Drug2 : DB01177 Idarubicin Pharmacological target (-,-) : BE0000742 DNA topoisomerase 2-alpha Non-common off-target(s) (drug1) : BE0002425 DNA topoisomerase 2-beta (-1) --------------------------------------------------- Drug1 : DB00694 Daunorubicin Drug2 : DB01204 Mitoxantrone Pharmacological target (-,-) : BE0000742 DNA topoisomerase 2-alpha Non-common off-target(s) (drug1) : BE0002425 DNA topoisomerase 2-beta (-1) --------------------------------------------------- Drug1 : DB00694 Daunorubicin Drug2 : DB01208 Sparfloxacin Pharmacological target (-,-) : BE0000742 DNA topoisomerase 2-alpha Non-common off-target(s) (drug1) : BE0002425 DNA topoisomerase 2-beta (-1) --------------------------------------------------- Drug1 : DB00694 Daunorubicin Drug2 : DB04576 Fleroxacin Pharmacological target (-,-) : BE0000742 DNA topoisomerase 2-alpha Non-common off-target(s) (drug1) : BE0002425 DNA topoisomerase 2-beta (-1) --------------------------------------------------- Drug1 : DB00694 Daunorubicin Drug2 : DB09047 Finafloxacin Pharmacological target (-,-) : BE0000742 DNA topoisomerase 2-alpha Non-common off-target(s) (drug1) : BE0002425 DNA topoisomerase 2-beta (-1) --------------------------------------------------- Drug1 : DB00695 Furosemide Drug2 : DB00774 Hydroflumethiazide Pharmacological target (-,-) : BE0000502 Solute carrier family 12 member 1 Non-common off-target(s) (drug2) : BE0000267 Carbonic anhydrase 1 (-1) BE0000322 Carbonic anhydrase 2 (-1) BE0000535 Carbonic anhydrase 4 (-1) BE0002437 Carbonic anhydrase 9 (-1) BE0001653 Carbonic anhydrase 12 (-1) --------------------------------------------------- Drug1 : DB00695 Furosemide Drug2 : DB00903 Ethacrynic acid Pharmacological target (-,-) : BE0000502 Solute carrier family 12 member 1 Non-common off-target(s) (drug2) : BE0000732 Sodium/potassium-transporting ATPase subunit alpha-1 (-1) --------------------------------------------------- Drug1 : DB00695 Furosemide Drug2 : DB01021 Trichlormethiazide Pharmacological target (-,-) : BE0000502 Solute carrier family 12 member 1 Non-common off-target(s) (drug2) : BE0000267 Carbonic anhydrase 1 (-1) BE0000322 Carbonic anhydrase 2 (-1) BE0000535 Carbonic anhydrase 4 (-1) BE0000732 Sodium/potassium-transporting ATPase subunit alpha-1 (-1) --------------------------------------------------- Drug1 : DB00699 Nicergoline Drug2 : DB00706 Tamsulosin Pharmacological target (-,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug2) : BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00699 Nicergoline Drug2 : DB00797 Tolazoline Pharmacological target (-,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug2) : BE0000442 Histamine H1 receptor (1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000112 Histamine H2 receptor (1) --------------------------------------------------- Drug1 : DB00699 Nicergoline Drug2 : DB00925 Phenoxybenzamine Pharmacological target (-,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug2) : BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00699 Nicergoline Drug2 : DB01136 Carvedilol Pharmacological target (-,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug2) : BE0000173 NADH dehydrogenase [ubiquinone] 1 subunit C2 (-1) BE0000172 Beta-1 adrenergic receptor (-1) BE0000694 Beta-2 adrenergic receptor (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0001114 Vascular cell adhesion protein 1 (-1) BE0001074 E-selectin (-1) --------------------------------------------------- Drug1 : DB00699 Nicergoline Drug2 : DB06207 Silodosin Pharmacological target (-,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug2) : BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00703 Methazolamide Drug2 : DB00819 Acetazolamide Pharmacological target (-,-) : BE0000267 Carbonic anhydrase 1 Pharmacological target (-,-) : BE0000322 Carbonic anhydrase 2 Pharmacological target (-,-) : BE0000535 Carbonic anhydrase 4 Pharmacological target (-,-) : BE0003629 Carbonic anhydrase 7 Non-common off-target(s) (drug2) : BE0003634 Carbonic anhydrase 14 (-1) BE0003625 Carbonic anhydrase 3 (-1) BE0000880 Aquaporin-1 (-1) --------------------------------------------------- Drug1 : DB00703 Methazolamide Drug2 : DB00880 Chlorothiazide Pharmacological target (-,-) : BE0000267 Carbonic anhydrase 1 Pharmacological target (-,-) : BE0000322 Carbonic anhydrase 2 Pharmacological target (-,-) : BE0000535 Carbonic anhydrase 4 Non-common off-target(s) (drug1) : BE0003629 Carbonic anhydrase 7 (-1) Non-common off-target(s) (drug2) : BE0000419 Solute carrier family 12 member 3 (-1) --------------------------------------------------- Drug1 : DB00703 Methazolamide Drug2 : DB01031 Ethinamate Pharmacological target (-,-) : BE0000267 Carbonic anhydrase 1 Pharmacological target (-,-) : BE0000322 Carbonic anhydrase 2 Non-common off-target(s) (drug1) : BE0000535 Carbonic anhydrase 4 (-1) BE0003629 Carbonic anhydrase 7 (-1) --------------------------------------------------- Drug1 : DB00703 Methazolamide Drug2 : DB01119 Diazoxide Pharmacological target (-,-) : BE0000267 Carbonic anhydrase 1 Pharmacological target (-,-) : BE0000322 Carbonic anhydrase 2 Non-common off-target(s) (drug1) : BE0000535 Carbonic anhydrase 4 (-1) BE0003629 Carbonic anhydrase 7 (-1) Non-common off-target(s) (drug2) : BE0000708 ATP-sensitive inward rectifier potassium channel 11 (1) --------------------------------------------------- Drug1 : DB00703 Methazolamide Drug2 : DB01144 Diclofenamide Pharmacological target (-,-) : BE0000267 Carbonic anhydrase 1 Pharmacological target (-,-) : BE0000322 Carbonic anhydrase 2 Pharmacological target (-,-) : BE0000535 Carbonic anhydrase 4 Pharmacological target (-,-) : BE0003629 Carbonic anhydrase 7 --------------------------------------------------- Drug1 : DB00704 Naltrexone Drug2 : DB01183 Naloxone Pharmacological target (-,-) : BE0000770 Mu-type opioid receptor Pharmacological target (-,-) : BE0000632 Kappa-type opioid receptor Pharmacological target (-,-) : BE0000420 Delta-type opioid receptor Non-common off-target(s) (drug1) : BE0000290 HCG20471, isoform CRA_c (-1) Non-common off-target(s) (drug2) : BE0000123 Estrogen receptor (-1) BE0002442 Toll-like receptor 4 (-1) --------------------------------------------------- Drug1 : DB00706 Tamsulosin Drug2 : DB00797 Tolazoline Pharmacological target (-,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000442 Histamine H1 receptor (1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000112 Histamine H2 receptor (1) --------------------------------------------------- Drug1 : DB00708 Sufentanil Drug2 : DB00802 Alfentanil Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000420 Delta-type opioid receptor (1) --------------------------------------------------- Drug1 : DB00708 Sufentanil Drug2 : DB00913 Anileridine Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000420 Delta-type opioid receptor (1) --------------------------------------------------- Drug1 : DB00708 Sufentanil Drug2 : DB01209 Dezocine Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000420 Delta-type opioid receptor (1) Non-common off-target(s) (drug2) : BE0000632 Kappa-type opioid receptor (-1) --------------------------------------------------- Drug1 : DB00708 Sufentanil Drug2 : DB01227 Levomethadyl Acetate Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000420 Delta-type opioid receptor (1) Non-common off-target(s) (drug2) : BE0003585 Neuronal acetylcholine receptor subunit alpha-3 (-1) --------------------------------------------------- Drug1 : DB00708 Sufentanil Drug2 : DB01433 Methadyl Acetate Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000420 Delta-type opioid receptor (1) --------------------------------------------------- Drug1 : DB00708 Sufentanil Drug2 : DB01466 Ethylmorphine Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000420 Delta-type opioid receptor (1) --------------------------------------------------- Drug1 : DB00708 Sufentanil Drug2 : DB06204 Tapentadol Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000420 Delta-type opioid receptor (1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB00710 Ibandronate Drug2 : DB00884 Risedronate Pharmacological target (-,-) : BE0000776 Farnesyl pyrophosphate synthase Pharmacological target (-,-) : BE0004801 Hydroxylapatite --------------------------------------------------- Drug1 : DB00710 Ibandronate Drug2 : DB01077 Etidronic acid Pharmacological target (-,-) : BE0004801 Hydroxylapatite Non-common off-target(s) (drug1) : BE0000776 Farnesyl pyrophosphate synthase (-1) Non-common off-target(s) (drug2) : BE0003567 Receptor-type tyrosine-protein phosphatase S (-1) BE0003569 V-type proton ATPase catalytic subunit A (-1) --------------------------------------------------- Drug1 : DB00710 Ibandronate Drug2 : DB01133 Tiludronate Pharmacological target (-,-) : BE0004801 Hydroxylapatite Non-common off-target(s) (drug1) : BE0000776 Farnesyl pyrophosphate synthase (-1) Non-common off-target(s) (drug2) : BE0003569 V-type proton ATPase catalytic subunit A (-1) BE0000623 Tyrosine-protein phosphatase non-receptor type 1 (-1) --------------------------------------------------- Drug1 : DB00711 Diethylcarbamazine Drug2 : DB00744 Zileuton Pharmacological target (-,-) : BE0000248 Arachidonate 5-lipoxygenase Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) --------------------------------------------------- Drug1 : DB00712 Flurbiprofen Drug2 : DB01050 Ibuprofen Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) Non-common off-target(s) (drug2) : BE0001088 Tissue-type plasminogen activator (-1) BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0001195 Cystic fibrosis transmembrane conductance regulator (-1) --------------------------------------------------- Drug1 : DB00712 Flurbiprofen Drug2 : DB01628 Etoricoxib Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) --------------------------------------------------- Drug1 : DB00712 Flurbiprofen Drug2 : DB04552 Niflumic Acid Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) Non-common off-target(s) (drug2) : BE0003997 Phospholipase A2 (-1) BE0002376 Chloride channel protein ClC-Ka (1) --------------------------------------------------- Drug1 : DB00712 Flurbiprofen Drug2 : DB04743 Nimesulide Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) --------------------------------------------------- Drug1 : DB00715 Paroxetine Drug2 : DB01104 Sertraline Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug1) : BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB00715 Paroxetine Drug2 : DB01191 Dexfenfluramine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug1) : BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) Non-common off-target(s) (drug2) : BE0000533 5-hydroxytryptamine receptor 2C (1) --------------------------------------------------- Drug1 : DB00716 Nedocromil Drug2 : DB01411 Pranlukast Pharmacological target (-,-) : BE0000705 Cysteinyl leukotriene receptor 1 Non-common off-target(s) (drug1) : BE0000099 Cysteinyl leukotriene receptor 2 (-1) BE0000995 fMet-Leu-Phe receptor (-1) Non-common off-target(s) (drug2) : BE0001208 Interleukin-5 (-1) --------------------------------------------------- Drug1 : DB00719 Azatadine Drug2 : DB00737 Meclizine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00719 Azatadine Drug2 : DB00748 Carbinoxamine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00719 Azatadine Drug2 : DB00751 Epinastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000112 Histamine H2 receptor (-1) --------------------------------------------------- Drug1 : DB00719 Azatadine Drug2 : DB00768 Olopatadine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0001090 Protein S100-A1 (-1) BE0001206 Protein S100-A12 (-1) BE0003602 Protein S100-A2 (-1) --------------------------------------------------- Drug1 : DB00719 Azatadine Drug2 : DB00777 Propiomazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00719 Azatadine Drug2 : DB00792 Tripelennamine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00719 Azatadine Drug2 : DB00835 Brompheniramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00719 Azatadine Drug2 : DB00902 Methdilazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00719 Azatadine Drug2 : DB00950 Fexofenadine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00719 Azatadine Drug2 : DB00967 Desloratadine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00719 Azatadine Drug2 : DB00972 Azelastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00719 Azatadine Drug2 : DB00985 Dimenhydrinate Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00719 Azatadine Drug2 : DB01069 Promethazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00719 Azatadine Drug2 : DB01071 Mequitazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00719 Azatadine Drug2 : DB01075 Diphenhydramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00719 Azatadine Drug2 : DB01084 Emedastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00719 Azatadine Drug2 : DB01106 Levocabastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000464 Neurotensin receptor type 2 (-1) --------------------------------------------------- Drug1 : DB00719 Azatadine Drug2 : DB01114 Chlorphenamine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB00719 Azatadine Drug2 : DB01146 Diphenylpyraline Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB00719 Azatadine Drug2 : DB01176 Cyclizine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000951 Estrogen sulfotransferase (-1) --------------------------------------------------- Drug1 : DB00719 Azatadine Drug2 : DB01237 Bromodiphenhydramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00719 Azatadine Drug2 : DB01246 Alimemazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00719 Azatadine Drug2 : DB01615 Aceprometazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00719 Azatadine Drug2 : DB01619 Phenindamine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00719 Azatadine Drug2 : DB01620 Pheniramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00719 Azatadine Drug2 : DB04837 Clofedanol Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00719 Azatadine Drug2 : DB04890 Bepotastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00719 Azatadine Drug2 : DB06691 Mepyramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00719 Azatadine Drug2 : DB08799 Antazoline Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00719 Azatadine Drug2 : DB08800 Chloropyramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00719 Azatadine Drug2 : DB08801 Dimetindene Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00719 Azatadine Drug2 : DB08802 Isothipendyl Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00719 Azatadine Drug2 : DB08936 Chlorcyclizine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00722 Lisinopril Drug2 : DB00790 Perindopril Pharmacological target (-,-) : BE0000221 Angiotensin-converting enzyme Non-common off-target(s) (drug1) : BE0000982 Angiotensin-converting enzyme 2 (-1) --------------------------------------------------- Drug1 : DB00722 Lisinopril Drug2 : DB00881 Quinapril Pharmacological target (-,-) : BE0000221 Angiotensin-converting enzyme Non-common off-target(s) (drug1) : BE0000982 Angiotensin-converting enzyme 2 (-1) --------------------------------------------------- Drug1 : DB00722 Lisinopril Drug2 : DB01180 Rescinnamine Pharmacological target (-,-) : BE0000221 Angiotensin-converting enzyme Non-common off-target(s) (drug1) : BE0000982 Angiotensin-converting enzyme 2 (-1) --------------------------------------------------- Drug1 : DB00722 Lisinopril Drug2 : DB01197 Captopril Pharmacological target (-,-) : BE0000221 Angiotensin-converting enzyme Non-common off-target(s) (drug1) : BE0000982 Angiotensin-converting enzyme 2 (-1) Non-common off-target(s) (drug2) : BE0000642 72 kDa type IV collagenase (-1) BE0000058 Matrix metalloproteinase-9 (-1) --------------------------------------------------- Drug1 : DB00722 Lisinopril Drug2 : DB01340 Cilazapril Pharmacological target (-,-) : BE0000221 Angiotensin-converting enzyme Non-common off-target(s) (drug1) : BE0000982 Angiotensin-converting enzyme 2 (-1) --------------------------------------------------- Drug1 : DB00722 Lisinopril Drug2 : DB01348 Spirapril Pharmacological target (-,-) : BE0000221 Angiotensin-converting enzyme Non-common off-target(s) (drug1) : BE0000982 Angiotensin-converting enzyme 2 (-1) --------------------------------------------------- Drug1 : DB00723 Methoxamine Drug2 : DB00964 Apraclonidine Pharmacological target (+,+) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000575 Alpha-1B adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00723 Methoxamine Drug2 : DB01253 Ergonovine Pharmacological target (+,+) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000575 Alpha-1B adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00723 Methoxamine Drug2 : DB06706 Isometheptene Pharmacological target (+,+) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000575 Alpha-1B adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (-1) --------------------------------------------------- Drug1 : DB00723 Methoxamine Drug2 : DB06707 Levonordefrin Pharmacological target (+,+) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000575 Alpha-1B adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB00723 Methoxamine Drug2 : DB06711 Naphazoline Pharmacological target (+,+) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000575 Alpha-1B adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00725 Homatropine Methylbromide Drug2 : DB00767 Benzquinamide Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Pharmacological target (-,-) : BE0000405 Muscarinic acetylcholine receptor M4 Pharmacological target (-,-) : BE0000247 Muscarinic acetylcholine receptor M5 Non-common off-target(s) (drug2) : BE0000442 Histamine H1 receptor (-1) --------------------------------------------------- Drug1 : DB00725 Homatropine Methylbromide Drug2 : DB00785 Cryptenamine Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Pharmacological target (-,-) : BE0000405 Muscarinic acetylcholine receptor M4 Pharmacological target (-,-) : BE0000247 Muscarinic acetylcholine receptor M5 --------------------------------------------------- Drug1 : DB00725 Homatropine Methylbromide Drug2 : DB01036 Tolterodine Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Pharmacological target (-,-) : BE0000405 Muscarinic acetylcholine receptor M4 Pharmacological target (-,-) : BE0000247 Muscarinic acetylcholine receptor M5 --------------------------------------------------- Drug1 : DB00725 Homatropine Methylbromide Drug2 : DB01062 Oxybutynin Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00725 Homatropine Methylbromide Drug2 : DB01231 Diphenidol Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00725 Homatropine Methylbromide Drug2 : DB08897 Aclidinium Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Pharmacological target (-,-) : BE0000405 Muscarinic acetylcholine receptor M4 Pharmacological target (-,-) : BE0000247 Muscarinic acetylcholine receptor M5 --------------------------------------------------- Drug1 : DB00726 Trimipramine Drug2 : DB04896 Milnacipran Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (1) BE0000289 Alpha-2A adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0004956 NMDA receptor (-1) --------------------------------------------------- Drug1 : DB00726 Trimipramine Drug2 : DB06700 Desvenlafaxine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (1) BE0000289 Alpha-2A adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00726 Trimipramine Drug2 : DB08918 Levomilnacipran Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (1) BE0000289 Alpha-2A adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00727 Nitroglycerin Drug2 : DB00883 Isosorbide Dinitrate Pharmacological target (+,+) : BE0000556 Atrial natriuretic peptide receptor 1 --------------------------------------------------- Drug1 : DB00727 Nitroglycerin Drug2 : DB01612 Amyl Nitrite Pharmacological target (+,+) : BE0000556 Atrial natriuretic peptide receptor 1 --------------------------------------------------- Drug1 : DB00727 Nitroglycerin Drug2 : DB01613 Erythrityl Tetranitrate Pharmacological target (+,+) : BE0000556 Atrial natriuretic peptide receptor 1 Non-common off-target(s) (drug2) : BE0000997 Atrial natriuretic peptide receptor 2 (1) --------------------------------------------------- Drug1 : DB00728 Rocuronium Drug2 : DB00732 Atracurium Pharmacological target (-,-) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 Non-common off-target(s) (drug1) : BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) --------------------------------------------------- Drug1 : DB00728 Rocuronium Drug2 : DB00810 Biperiden Pharmacological target (-,-) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 Non-common off-target(s) (drug1) : BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) Non-common off-target(s) (drug2) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) --------------------------------------------------- Drug1 : DB00728 Rocuronium Drug2 : DB01148 Flavoxate Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) Non-common off-target(s) (drug2) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) --------------------------------------------------- Drug1 : DB00728 Rocuronium Drug2 : DB01226 Mivacurium Pharmacological target (-,-) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 Non-common off-target(s) (drug1) : BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) --------------------------------------------------- Drug1 : DB00728 Rocuronium Drug2 : DB01339 Vecuronium Pharmacological target (-,-) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 Non-common off-target(s) (drug1) : BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) --------------------------------------------------- Drug1 : DB00728 Rocuronium Drug2 : DB08801 Dimetindene Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) Non-common off-target(s) (drug2) : BE0000442 Histamine H1 receptor (-1) --------------------------------------------------- Drug1 : DB00728 Rocuronium Drug2 : DB09076 Umeclidinium Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00729 Diphemanil Methylsulfate Drug2 : DB01409 Tiotropium Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Non-common off-target(s) (drug2) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00729 Diphemanil Methylsulfate Drug2 : DB01591 Solifenacin Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Non-common off-target(s) (drug2) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00729 Diphemanil Methylsulfate Drug2 : DB01625 Isopropamide Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Non-common off-target(s) (drug2) : BE0000405 Muscarinic acetylcholine receptor M4 (-1) --------------------------------------------------- Drug1 : DB00729 Diphemanil Methylsulfate Drug2 : DB04843 Mepenzolate Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Non-common off-target(s) (drug2) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) --------------------------------------------------- Drug1 : DB00729 Diphemanil Methylsulfate Drug2 : DB06702 Fesoterodine Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Non-common off-target(s) (drug2) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00729 Diphemanil Methylsulfate Drug2 : DB09076 Umeclidinium Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Non-common off-target(s) (drug2) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00731 Nateglinide Drug2 : DB01124 Tolbutamide Pharmacological target (-,-) : BE0000207 ATP-binding cassette sub-family C member 8 Non-common off-target(s) (drug1) : BE0000215 Peroxisome proliferator-activated receptor gamma (1) Non-common off-target(s) (drug2) : BE0000644 ATP-sensitive inward rectifier potassium channel 1 (-1) --------------------------------------------------- Drug1 : DB00731 Nateglinide Drug2 : DB01251 Gliquidone Pharmacological target (-,-) : BE0000207 ATP-binding cassette sub-family C member 8 Non-common off-target(s) (drug1) : BE0000215 Peroxisome proliferator-activated receptor gamma (1) Non-common off-target(s) (drug2) : BE0002441 ATP-sensitive inward rectifier potassium channel 8 (-1) --------------------------------------------------- Drug1 : DB00732 Atracurium Drug2 : DB00810 Biperiden Pharmacological target (-,-) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 Non-common off-target(s) (drug2) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) --------------------------------------------------- Drug1 : DB00732 Atracurium Drug2 : DB01135 Doxacurium chloride Pharmacological target (-,-) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 Non-common off-target(s) (drug2) : BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00732 Atracurium Drug2 : DB01199 Tubocurarine Pharmacological target (-,-) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 Non-common off-target(s) (drug2) : BE0000426 Acetylcholinesterase (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) --------------------------------------------------- Drug1 : DB00732 Atracurium Drug2 : DB01226 Mivacurium Pharmacological target (-,-) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) --------------------------------------------------- Drug1 : DB00732 Atracurium Drug2 : DB01336 Metocurine Pharmacological target (-,-) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 Non-common off-target(s) (drug2) : BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00732 Atracurium Drug2 : DB01337 Pancuronium Pharmacological target (-,-) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00732 Atracurium Drug2 : DB01338 Pipecuronium Pharmacological target (-,-) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00732 Atracurium Drug2 : DB01339 Vecuronium Pharmacological target (-,-) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 --------------------------------------------------- Drug1 : DB00734 Risperidone Drug2 : DB00924 Cyclobenzaprine Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000659 5-hydroxytryptamine receptor 1D (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00734 Risperidone Drug2 : DB00933 Mesoridazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000659 5-hydroxytryptamine receptor 1D (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00734 Risperidone Drug2 : DB01233 Metoclopramide Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000659 5-hydroxytryptamine receptor 1D (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000092 Muscarinic acetylcholine receptor M1 (1) BE0000311 5-hydroxytryptamine receptor 3A (1) BE0000084 5-hydroxytryptamine receptor 4 (1) --------------------------------------------------- Drug1 : DB00734 Risperidone Drug2 : DB01425 Alizapride Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000659 5-hydroxytryptamine receptor 1D (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00734 Risperidone Drug2 : DB09018 Bromopride Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000659 5-hydroxytryptamine receptor 1D (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00735 Naftifine Drug2 : DB00857 Terbinafine Pharmacological target (-,-) : BE0000577 Squalene monooxygenase --------------------------------------------------- Drug1 : DB00735 Naftifine Drug2 : DB01091 Butenafine Pharmacological target (-,-) : BE0000577 Squalene monooxygenase --------------------------------------------------- Drug1 : DB00736 Esomeprazole Drug2 : DB01129 Rabeprazole Pharmacological target (-,-) : BE0000349 Potassium-transporting ATPase alpha chain 1 --------------------------------------------------- Drug1 : DB00737 Meclizine Drug2 : DB00748 Carbinoxamine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00737 Meclizine Drug2 : DB00751 Epinastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000112 Histamine H2 receptor (-1) --------------------------------------------------- Drug1 : DB00737 Meclizine Drug2 : DB00768 Olopatadine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0001090 Protein S100-A1 (-1) BE0001206 Protein S100-A12 (-1) BE0003602 Protein S100-A2 (-1) --------------------------------------------------- Drug1 : DB00737 Meclizine Drug2 : DB00777 Propiomazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00737 Meclizine Drug2 : DB00792 Tripelennamine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00737 Meclizine Drug2 : DB00835 Brompheniramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00737 Meclizine Drug2 : DB00902 Methdilazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00737 Meclizine Drug2 : DB00950 Fexofenadine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00737 Meclizine Drug2 : DB00967 Desloratadine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00737 Meclizine Drug2 : DB00972 Azelastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00737 Meclizine Drug2 : DB00985 Dimenhydrinate Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00737 Meclizine Drug2 : DB01069 Promethazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00737 Meclizine Drug2 : DB01071 Mequitazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00737 Meclizine Drug2 : DB01075 Diphenhydramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00737 Meclizine Drug2 : DB01084 Emedastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00737 Meclizine Drug2 : DB01106 Levocabastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000464 Neurotensin receptor type 2 (-1) --------------------------------------------------- Drug1 : DB00737 Meclizine Drug2 : DB01114 Chlorphenamine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB00737 Meclizine Drug2 : DB01146 Diphenylpyraline Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB00737 Meclizine Drug2 : DB01176 Cyclizine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000951 Estrogen sulfotransferase (-1) --------------------------------------------------- Drug1 : DB00737 Meclizine Drug2 : DB01237 Bromodiphenhydramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00737 Meclizine Drug2 : DB01246 Alimemazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00737 Meclizine Drug2 : DB01615 Aceprometazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00737 Meclizine Drug2 : DB01619 Phenindamine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00737 Meclizine Drug2 : DB01620 Pheniramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00737 Meclizine Drug2 : DB04837 Clofedanol Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00737 Meclizine Drug2 : DB04890 Bepotastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00737 Meclizine Drug2 : DB06691 Mepyramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00737 Meclizine Drug2 : DB08799 Antazoline Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00737 Meclizine Drug2 : DB08800 Chloropyramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00737 Meclizine Drug2 : DB08801 Dimetindene Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00737 Meclizine Drug2 : DB08802 Isothipendyl Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00737 Meclizine Drug2 : DB08936 Chlorcyclizine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00740 Riluzole Drug2 : DB00750 Prilocaine Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0000030 Cystine/glutamate transporter (1) --------------------------------------------------- Drug1 : DB00740 Riluzole Drug2 : DB00754 Ethotoin Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0000030 Cystine/glutamate transporter (1) --------------------------------------------------- Drug1 : DB00740 Riluzole Drug2 : DB00776 Oxcarbazepine Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0000030 Cystine/glutamate transporter (1) --------------------------------------------------- Drug1 : DB00740 Riluzole Drug2 : DB00908 Quinidine Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0000030 Cystine/glutamate transporter (1) Non-common off-target(s) (drug2) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000154 Potassium channel subfamily K member 1 (-1) BE0000680 Potassium channel subfamily K member 6 (-1) --------------------------------------------------- Drug1 : DB00740 Riluzole Drug2 : DB01056 Tocainide Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0000030 Cystine/glutamate transporter (1) --------------------------------------------------- Drug1 : DB00740 Riluzole Drug2 : DB01182 Propafenone Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0000030 Cystine/glutamate transporter (1) Non-common off-target(s) (drug2) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) --------------------------------------------------- Drug1 : DB00740 Riluzole Drug2 : DB01195 Flecainide Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0000030 Cystine/glutamate transporter (1) Non-common off-target(s) (drug2) : BE0002083 Sodium channel protein type 4 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00740 Riluzole Drug2 : DB01228 Encainide Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0000030 Cystine/glutamate transporter (1) --------------------------------------------------- Drug1 : DB00740 Riluzole Drug2 : DB01320 Fosphenytoin Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0000030 Cystine/glutamate transporter (1) --------------------------------------------------- Drug1 : DB00740 Riluzole Drug2 : DB01426 Ajmaline Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0000030 Cystine/glutamate transporter (1) --------------------------------------------------- Drug1 : DB00740 Riluzole Drug2 : DB01429 Aprindine Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0000030 Cystine/glutamate transporter (1) Non-common off-target(s) (drug2) : BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00740 Riluzole Drug2 : DB06151 Acetylcysteine Pharmacological target (+,+) : BE0000030 Cystine/glutamate transporter Non-common off-target(s) (drug1) : BE0000197 Sodium channel protein type 5 subunit alpha (-1) Non-common off-target(s) (drug2) : BE0000396 Glutamate receptor ionotropic, NMDA 2D (1) BE0000365 Glutamate receptor ionotropic, NMDA 1 (1) BE0000760 Glutamate receptor ionotropic, NMDA 2A (1) BE0000417 Glutamate receptor ionotropic, NMDA 2B (1) BE0000641 Glutamate receptor ionotropic, NMDA 3A (1) BE0000185 Glutathione synthetase (1) BE0004655 Inhibitor of nuclear factor kappa-B kinase subunit alpha (-1) BE0001154 Inhibitor of nuclear factor kappa-B kinase subunit beta (-1) BE0004839 NAPQI (N-acetyl-p-benzoquinone imine) (-1) --------------------------------------------------- Drug1 : DB00741 Hydrocortisone Drug2 : DB00764 Mometasone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug1) : BE0000422 Annexin A1 (1) --------------------------------------------------- Drug1 : DB00741 Hydrocortisone Drug2 : DB00769 Hydrocortamate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug1) : BE0000422 Annexin A1 (1) --------------------------------------------------- Drug1 : DB00741 Hydrocortisone Drug2 : DB00838 Clocortolone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug1) : BE0000422 Annexin A1 (1) --------------------------------------------------- Drug1 : DB00741 Hydrocortisone Drug2 : DB00846 Flurandrenolide Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug1) : BE0000422 Annexin A1 (1) --------------------------------------------------- Drug1 : DB00741 Hydrocortisone Drug2 : DB00860 Prednisolone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug1) : BE0000422 Annexin A1 (1) --------------------------------------------------- Drug1 : DB00741 Hydrocortisone Drug2 : DB00873 Loteprednol Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug1) : BE0000422 Annexin A1 (1) --------------------------------------------------- Drug1 : DB00741 Hydrocortisone Drug2 : DB00896 Rimexolone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug1) : BE0000422 Annexin A1 (1) --------------------------------------------------- Drug1 : DB00741 Hydrocortisone Drug2 : DB00959 Methylprednisolone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug1) : BE0000422 Annexin A1 (1) --------------------------------------------------- Drug1 : DB00741 Hydrocortisone Drug2 : DB01013 Clobetasol propionate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug1) : BE0000422 Annexin A1 (1) --------------------------------------------------- Drug1 : DB00741 Hydrocortisone Drug2 : DB01047 Fluocinonide Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug1) : BE0000422 Annexin A1 (1) Non-common off-target(s) (drug2) : BE0004659 Smoothened homolog (1) --------------------------------------------------- Drug1 : DB00741 Hydrocortisone Drug2 : DB01130 Prednicarbate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug1) : BE0000422 Annexin A1 (1) --------------------------------------------------- Drug1 : DB00741 Hydrocortisone Drug2 : DB01260 Desonide Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug1) : BE0000422 Annexin A1 (1) --------------------------------------------------- Drug1 : DB00741 Hydrocortisone Drug2 : DB01380 Cortisone acetate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug1) : BE0000422 Annexin A1 (1) --------------------------------------------------- Drug1 : DB00741 Hydrocortisone Drug2 : DB01384 Paramethasone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug1) : BE0000422 Annexin A1 (1) --------------------------------------------------- Drug1 : DB00741 Hydrocortisone Drug2 : DB01410 Ciclesonide Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug1) : BE0000422 Annexin A1 (1) --------------------------------------------------- Drug1 : DB00741 Hydrocortisone Drug2 : DB06781 Difluprednate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug1) : BE0000422 Annexin A1 (1) --------------------------------------------------- Drug1 : DB00741 Hydrocortisone Drug2 : DB08906 Fluticasone furoate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug1) : BE0000422 Annexin A1 (1) --------------------------------------------------- Drug1 : DB00745 Modafinil Drug2 : DB00830 Phenmetrazine Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Non-common off-target(s) (drug1) : BE0000575 Alpha-1B adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB00745 Modafinil Drug2 : DB00937 Diethylpropion Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Non-common off-target(s) (drug1) : BE0000575 Alpha-1B adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB00745 Modafinil Drug2 : DB01156 Bupropion Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Non-common off-target(s) (drug1) : BE0000575 Alpha-1B adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0003585 Neuronal acetylcholine receptor subunit alpha-3 (-1) --------------------------------------------------- Drug1 : DB00745 Modafinil Drug2 : DB01463 Fencamfamine Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Non-common off-target(s) (drug1) : BE0000575 Alpha-1B adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00745 Modafinil Drug2 : DB06701 Dexmethylphenidate Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Non-common off-target(s) (drug1) : BE0000575 Alpha-1B adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB00747 Scopolamine Drug2 : DB00771 Clidinium Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0001176 Sucrase-isomaltase, intestinal (-1) --------------------------------------------------- Drug1 : DB00747 Scopolamine Drug2 : DB00782 Propantheline Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0001176 Sucrase-isomaltase, intestinal (-1) --------------------------------------------------- Drug1 : DB00747 Scopolamine Drug2 : DB00810 Biperiden Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0001176 Sucrase-isomaltase, intestinal (-1) Non-common off-target(s) (drug2) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) --------------------------------------------------- Drug1 : DB00747 Scopolamine Drug2 : DB00942 Cycrimine Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0001176 Sucrase-isomaltase, intestinal (-1) --------------------------------------------------- Drug1 : DB00747 Scopolamine Drug2 : DB00979 Cyclopentolate Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0001176 Sucrase-isomaltase, intestinal (-1) --------------------------------------------------- Drug1 : DB00748 Carbinoxamine Drug2 : DB00751 Epinastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000112 Histamine H2 receptor (-1) --------------------------------------------------- Drug1 : DB00748 Carbinoxamine Drug2 : DB00768 Olopatadine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0001090 Protein S100-A1 (-1) BE0001206 Protein S100-A12 (-1) BE0003602 Protein S100-A2 (-1) --------------------------------------------------- Drug1 : DB00748 Carbinoxamine Drug2 : DB00777 Propiomazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00748 Carbinoxamine Drug2 : DB00792 Tripelennamine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00748 Carbinoxamine Drug2 : DB00835 Brompheniramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00748 Carbinoxamine Drug2 : DB00902 Methdilazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00748 Carbinoxamine Drug2 : DB00950 Fexofenadine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00748 Carbinoxamine Drug2 : DB00967 Desloratadine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00748 Carbinoxamine Drug2 : DB00972 Azelastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00748 Carbinoxamine Drug2 : DB00985 Dimenhydrinate Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00748 Carbinoxamine Drug2 : DB01069 Promethazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00748 Carbinoxamine Drug2 : DB01071 Mequitazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00748 Carbinoxamine Drug2 : DB01075 Diphenhydramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00748 Carbinoxamine Drug2 : DB01084 Emedastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00748 Carbinoxamine Drug2 : DB01106 Levocabastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000464 Neurotensin receptor type 2 (-1) --------------------------------------------------- Drug1 : DB00748 Carbinoxamine Drug2 : DB01114 Chlorphenamine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB00748 Carbinoxamine Drug2 : DB01146 Diphenylpyraline Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB00748 Carbinoxamine Drug2 : DB01176 Cyclizine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000951 Estrogen sulfotransferase (-1) --------------------------------------------------- Drug1 : DB00748 Carbinoxamine Drug2 : DB01237 Bromodiphenhydramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00748 Carbinoxamine Drug2 : DB01246 Alimemazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00748 Carbinoxamine Drug2 : DB01615 Aceprometazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00748 Carbinoxamine Drug2 : DB01619 Phenindamine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00748 Carbinoxamine Drug2 : DB01620 Pheniramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00748 Carbinoxamine Drug2 : DB04837 Clofedanol Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00748 Carbinoxamine Drug2 : DB04890 Bepotastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00748 Carbinoxamine Drug2 : DB06691 Mepyramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00748 Carbinoxamine Drug2 : DB08799 Antazoline Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00748 Carbinoxamine Drug2 : DB08800 Chloropyramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00748 Carbinoxamine Drug2 : DB08801 Dimetindene Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00748 Carbinoxamine Drug2 : DB08802 Isothipendyl Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00748 Carbinoxamine Drug2 : DB08936 Chlorcyclizine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00749 Etodolac Drug2 : DB01050 Ibuprofen Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) Non-common off-target(s) (drug2) : BE0001088 Tissue-type plasminogen activator (-1) BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0001195 Cystic fibrosis transmembrane conductance regulator (-1) --------------------------------------------------- Drug1 : DB00749 Etodolac Drug2 : DB01628 Etoricoxib Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) --------------------------------------------------- Drug1 : DB00749 Etodolac Drug2 : DB04552 Niflumic Acid Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) Non-common off-target(s) (drug2) : BE0003997 Phospholipase A2 (-1) BE0002376 Chloride channel protein ClC-Ka (1) --------------------------------------------------- Drug1 : DB00749 Etodolac Drug2 : DB04743 Nimesulide Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) --------------------------------------------------- Drug1 : DB00750 Prilocaine Drug2 : DB00754 Ethotoin Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha --------------------------------------------------- Drug1 : DB00750 Prilocaine Drug2 : DB00776 Oxcarbazepine Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha --------------------------------------------------- Drug1 : DB00750 Prilocaine Drug2 : DB00908 Quinidine Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug2) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000154 Potassium channel subfamily K member 1 (-1) BE0000680 Potassium channel subfamily K member 6 (-1) --------------------------------------------------- Drug1 : DB00750 Prilocaine Drug2 : DB01056 Tocainide Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha --------------------------------------------------- Drug1 : DB00750 Prilocaine Drug2 : DB01182 Propafenone Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug2) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) --------------------------------------------------- Drug1 : DB00750 Prilocaine Drug2 : DB01195 Flecainide Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug2) : BE0002083 Sodium channel protein type 4 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00750 Prilocaine Drug2 : DB01228 Encainide Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha --------------------------------------------------- Drug1 : DB00750 Prilocaine Drug2 : DB01320 Fosphenytoin Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha --------------------------------------------------- Drug1 : DB00750 Prilocaine Drug2 : DB01426 Ajmaline Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha --------------------------------------------------- Drug1 : DB00750 Prilocaine Drug2 : DB01429 Aprindine Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug2) : BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00751 Epinastine Drug2 : DB00768 Olopatadine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000112 Histamine H2 receptor (-1) Non-common off-target(s) (drug2) : BE0001090 Protein S100-A1 (-1) BE0001206 Protein S100-A12 (-1) BE0003602 Protein S100-A2 (-1) --------------------------------------------------- Drug1 : DB00751 Epinastine Drug2 : DB00792 Tripelennamine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000112 Histamine H2 receptor (-1) --------------------------------------------------- Drug1 : DB00751 Epinastine Drug2 : DB00835 Brompheniramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000112 Histamine H2 receptor (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00751 Epinastine Drug2 : DB00863 Ranitidine Pharmacological target (-,-) : BE0000112 Histamine H2 receptor Non-common off-target(s) (drug1) : BE0000442 Histamine H1 receptor (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB00751 Epinastine Drug2 : DB00902 Methdilazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000112 Histamine H2 receptor (-1) --------------------------------------------------- Drug1 : DB00751 Epinastine Drug2 : DB00927 Famotidine Pharmacological target (-,-) : BE0000112 Histamine H2 receptor Non-common off-target(s) (drug1) : BE0000442 Histamine H1 receptor (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB00751 Epinastine Drug2 : DB00940 Methantheline Pharmacological target (-,-) : BE0000112 Histamine H2 receptor Non-common off-target(s) (drug1) : BE0000442 Histamine H1 receptor (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) Non-common off-target(s) (drug2) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) --------------------------------------------------- Drug1 : DB00751 Epinastine Drug2 : DB00950 Fexofenadine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000112 Histamine H2 receptor (-1) --------------------------------------------------- Drug1 : DB00751 Epinastine Drug2 : DB00967 Desloratadine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000112 Histamine H2 receptor (-1) --------------------------------------------------- Drug1 : DB00751 Epinastine Drug2 : DB00972 Azelastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000112 Histamine H2 receptor (-1) --------------------------------------------------- Drug1 : DB00751 Epinastine Drug2 : DB00985 Dimenhydrinate Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000112 Histamine H2 receptor (-1) --------------------------------------------------- Drug1 : DB00751 Epinastine Drug2 : DB01071 Mequitazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000112 Histamine H2 receptor (-1) --------------------------------------------------- Drug1 : DB00751 Epinastine Drug2 : DB01075 Diphenhydramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000112 Histamine H2 receptor (-1) --------------------------------------------------- Drug1 : DB00751 Epinastine Drug2 : DB01084 Emedastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000112 Histamine H2 receptor (-1) --------------------------------------------------- Drug1 : DB00751 Epinastine Drug2 : DB01106 Levocabastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000112 Histamine H2 receptor (-1) Non-common off-target(s) (drug2) : BE0000464 Neurotensin receptor type 2 (-1) --------------------------------------------------- Drug1 : DB00751 Epinastine Drug2 : DB01114 Chlorphenamine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000112 Histamine H2 receptor (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB00751 Epinastine Drug2 : DB01146 Diphenylpyraline Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000112 Histamine H2 receptor (-1) Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB00751 Epinastine Drug2 : DB01176 Cyclizine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000112 Histamine H2 receptor (-1) Non-common off-target(s) (drug2) : BE0000951 Estrogen sulfotransferase (-1) --------------------------------------------------- Drug1 : DB00751 Epinastine Drug2 : DB01237 Bromodiphenhydramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000112 Histamine H2 receptor (-1) --------------------------------------------------- Drug1 : DB00751 Epinastine Drug2 : DB01246 Alimemazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000112 Histamine H2 receptor (-1) --------------------------------------------------- Drug1 : DB00751 Epinastine Drug2 : DB01615 Aceprometazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000112 Histamine H2 receptor (-1) --------------------------------------------------- Drug1 : DB00751 Epinastine Drug2 : DB01619 Phenindamine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000112 Histamine H2 receptor (-1) --------------------------------------------------- Drug1 : DB00751 Epinastine Drug2 : DB01620 Pheniramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000112 Histamine H2 receptor (-1) --------------------------------------------------- Drug1 : DB00751 Epinastine Drug2 : DB04837 Clofedanol Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000112 Histamine H2 receptor (-1) --------------------------------------------------- Drug1 : DB00751 Epinastine Drug2 : DB04890 Bepotastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000112 Histamine H2 receptor (-1) --------------------------------------------------- Drug1 : DB00751 Epinastine Drug2 : DB06691 Mepyramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000112 Histamine H2 receptor (-1) --------------------------------------------------- Drug1 : DB00751 Epinastine Drug2 : DB08799 Antazoline Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000112 Histamine H2 receptor (-1) --------------------------------------------------- Drug1 : DB00751 Epinastine Drug2 : DB08800 Chloropyramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000112 Histamine H2 receptor (-1) --------------------------------------------------- Drug1 : DB00751 Epinastine Drug2 : DB08801 Dimetindene Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000112 Histamine H2 receptor (-1) Non-common off-target(s) (drug2) : BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00751 Epinastine Drug2 : DB08802 Isothipendyl Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000112 Histamine H2 receptor (-1) --------------------------------------------------- Drug1 : DB00751 Epinastine Drug2 : DB08805 Metiamide Pharmacological target (-,-) : BE0000112 Histamine H2 receptor Non-common off-target(s) (drug1) : BE0000442 Histamine H1 receptor (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB00751 Epinastine Drug2 : DB08806 Roxatidine acetate Pharmacological target (-,-) : BE0000112 Histamine H2 receptor Non-common off-target(s) (drug1) : BE0000442 Histamine H1 receptor (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB00751 Epinastine Drug2 : DB08936 Chlorcyclizine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000112 Histamine H2 receptor (-1) --------------------------------------------------- Drug1 : DB00752 Tranylcypromine Drug2 : DB00780 Phenelzine Pharmacological target (-,-) : BE0002196 Amine oxidase [flavin-containing] B Pharmacological target (-,-) : BE0002198 Amine oxidase [flavin-containing] A Non-common off-target(s) (drug2) : BE0000253 4-aminobutyrate aminotransferase, mitochondrial (-1) BE0000667 Alanine aminotransferase 1 (-1) BE0002166 Alanine aminotransferase 2 (-1) BE0002173 Glutamic acid decarboxylase (-1) BE0001002 Membrane primary amine oxidase (-1) --------------------------------------------------- Drug1 : DB00752 Tranylcypromine Drug2 : DB01171 Moclobemide Pharmacological target (-,-) : BE0002198 Amine oxidase [flavin-containing] A Non-common off-target(s) (drug1) : BE0002196 Amine oxidase [flavin-containing] B (-1) --------------------------------------------------- Drug1 : DB00752 Tranylcypromine Drug2 : DB01247 Isocarboxazid Pharmacological target (-,-) : BE0002196 Amine oxidase [flavin-containing] B Pharmacological target (-,-) : BE0002198 Amine oxidase [flavin-containing] A --------------------------------------------------- Drug1 : DB00752 Tranylcypromine Drug2 : DB01367 Rasagiline Pharmacological target (-,-) : BE0002196 Amine oxidase [flavin-containing] B Non-common off-target(s) (drug1) : BE0002198 Amine oxidase [flavin-containing] A (-1) Non-common off-target(s) (drug2) : BE0000246 Apoptosis regulator Bcl-2 (1) --------------------------------------------------- Drug1 : DB00753 Isoflurane Drug2 : DB01189 Desflurane Pharmacological target (+,+) : BE0000433 Glycine receptor subunit alpha-1 Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000781 Potassium voltage-gated channel subfamily A member 1 Pharmacological target (-,-) : BE0000640 Glutamate receptor 1 Pharmacological target (-,-) : BE0000218 Calcium-transporting ATPase type 2C member 1 Non-common off-target(s) (drug1) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) --------------------------------------------------- Drug1 : DB00753 Isoflurane Drug2 : DB01236 Sevoflurane Pharmacological target (+,+) : BE0000433 Glycine receptor subunit alpha-1 Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000781 Potassium voltage-gated channel subfamily A member 1 Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (-,-) : BE0000640 Glutamate receptor 1 Pharmacological target (-,-) : BE0000218 Calcium-transporting ATPase type 2C member 1 --------------------------------------------------- Drug1 : DB00754 Ethotoin Drug2 : DB00776 Oxcarbazepine Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha --------------------------------------------------- Drug1 : DB00754 Ethotoin Drug2 : DB00908 Quinidine Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug2) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000154 Potassium channel subfamily K member 1 (-1) BE0000680 Potassium channel subfamily K member 6 (-1) --------------------------------------------------- Drug1 : DB00754 Ethotoin Drug2 : DB01056 Tocainide Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha --------------------------------------------------- Drug1 : DB00754 Ethotoin Drug2 : DB01182 Propafenone Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug2) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) --------------------------------------------------- Drug1 : DB00754 Ethotoin Drug2 : DB01195 Flecainide Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug2) : BE0002083 Sodium channel protein type 4 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00754 Ethotoin Drug2 : DB01228 Encainide Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha --------------------------------------------------- Drug1 : DB00754 Ethotoin Drug2 : DB01320 Fosphenytoin Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha --------------------------------------------------- Drug1 : DB00754 Ethotoin Drug2 : DB01426 Ajmaline Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha --------------------------------------------------- Drug1 : DB00754 Ethotoin Drug2 : DB01429 Aprindine Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug2) : BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00755 Tretinoin Drug2 : DB00799 Tazarotene Pharmacological target (+,+) : BE0000144 Retinoic acid receptor gamma Pharmacological target (+,+) : BE0000078 Retinoic acid receptor RXR-beta Non-common off-target(s) (drug1) : BE0000707 Retinoic acid receptor RXR-gamma (1) BE0000653 Retinoic acid receptor responder protein 1 (1) Non-common off-target(s) (drug2) : BE0000206 Retinoic acid receptor beta (1) BE0000663 Retinoic acid receptor alpha (1) --------------------------------------------------- Drug1 : DB00755 Tretinoin Drug2 : DB00926 Etretinate Pharmacological target (+,+) : BE0000144 Retinoic acid receptor gamma Pharmacological target (+,+) : BE0000707 Retinoic acid receptor RXR-gamma Pharmacological target (+,+) : BE0000078 Retinoic acid receptor RXR-beta Non-common off-target(s) (drug1) : BE0000653 Retinoic acid receptor responder protein 1 (1) Non-common off-target(s) (drug2) : BE0000206 Retinoic acid receptor beta (1) BE0000663 Retinoic acid receptor alpha (1) BE0000412 Retinoic acid receptor RXR-alpha (1) --------------------------------------------------- Drug1 : DB00757 Dolasetron Drug2 : DB00889 Granisetron Pharmacological target (-,-) : BE0000311 5-hydroxytryptamine receptor 3A --------------------------------------------------- Drug1 : DB00757 Dolasetron Drug2 : DB00904 Ondansetron Pharmacological target (-,-) : BE0000311 5-hydroxytryptamine receptor 3A Non-common off-target(s) (drug2) : BE0000084 5-hydroxytryptamine receptor 4 (1) --------------------------------------------------- Drug1 : DB00757 Dolasetron Drug2 : DB00969 Alosetron Pharmacological target (-,-) : BE0000311 5-hydroxytryptamine receptor 3A --------------------------------------------------- Drug1 : DB00757 Dolasetron Drug2 : DB01199 Tubocurarine Pharmacological target (-,-) : BE0000311 5-hydroxytryptamine receptor 3A Non-common off-target(s) (drug2) : BE0000426 Acetylcholinesterase (-1) BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) --------------------------------------------------- Drug1 : DB00758 Clopidogrel Drug2 : DB06209 Prasugrel Pharmacological target (-,-) : BE0000110 P2Y purinoceptor 12 --------------------------------------------------- Drug1 : DB00758 Clopidogrel Drug2 : DB08816 Ticagrelor Pharmacological target (-,-) : BE0000110 P2Y purinoceptor 12 --------------------------------------------------- Drug1 : DB00762 Irinotecan Drug2 : DB05630 Sodium stibogluconate Pharmacological target (-,-) : BE0000971 DNA topoisomerase 1 Non-common off-target(s) (drug1) : BE0000091 DNA topoisomerase I, mitochondrial (-1) --------------------------------------------------- Drug1 : DB00764 Mometasone Drug2 : DB00769 Hydrocortamate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00764 Mometasone Drug2 : DB00838 Clocortolone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00764 Mometasone Drug2 : DB00846 Flurandrenolide Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00764 Mometasone Drug2 : DB00860 Prednisolone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00764 Mometasone Drug2 : DB00873 Loteprednol Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00764 Mometasone Drug2 : DB00896 Rimexolone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00764 Mometasone Drug2 : DB00959 Methylprednisolone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00764 Mometasone Drug2 : DB01013 Clobetasol propionate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00764 Mometasone Drug2 : DB01047 Fluocinonide Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug2) : BE0004659 Smoothened homolog (1) --------------------------------------------------- Drug1 : DB00764 Mometasone Drug2 : DB01130 Prednicarbate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00764 Mometasone Drug2 : DB01234 Dexamethasone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug2) : BE0000005 Nitric oxide synthase, inducible (-1) BE0000422 Annexin A1 (1) BE0000074 Nuclear receptor subfamily 0 group B member 1 (1) --------------------------------------------------- Drug1 : DB00764 Mometasone Drug2 : DB01260 Desonide Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00764 Mometasone Drug2 : DB01380 Cortisone acetate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00764 Mometasone Drug2 : DB01384 Paramethasone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00764 Mometasone Drug2 : DB01410 Ciclesonide Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00764 Mometasone Drug2 : DB06781 Difluprednate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00764 Mometasone Drug2 : DB08906 Fluticasone furoate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00767 Benzquinamide Drug2 : DB00785 Cryptenamine Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Pharmacological target (-,-) : BE0000405 Muscarinic acetylcholine receptor M4 Pharmacological target (-,-) : BE0000247 Muscarinic acetylcholine receptor M5 Non-common off-target(s) (drug1) : BE0000442 Histamine H1 receptor (-1) --------------------------------------------------- Drug1 : DB00767 Benzquinamide Drug2 : DB01036 Tolterodine Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Pharmacological target (-,-) : BE0000405 Muscarinic acetylcholine receptor M4 Pharmacological target (-,-) : BE0000247 Muscarinic acetylcholine receptor M5 Non-common off-target(s) (drug1) : BE0000442 Histamine H1 receptor (-1) --------------------------------------------------- Drug1 : DB00767 Benzquinamide Drug2 : DB01062 Oxybutynin Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000442 Histamine H1 receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00767 Benzquinamide Drug2 : DB01231 Diphenidol Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000442 Histamine H1 receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00767 Benzquinamide Drug2 : DB08897 Aclidinium Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Pharmacological target (-,-) : BE0000405 Muscarinic acetylcholine receptor M4 Pharmacological target (-,-) : BE0000247 Muscarinic acetylcholine receptor M5 Non-common off-target(s) (drug1) : BE0000442 Histamine H1 receptor (-1) --------------------------------------------------- Drug1 : DB00768 Olopatadine Drug2 : DB00777 Propiomazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0001090 Protein S100-A1 (-1) BE0001206 Protein S100-A12 (-1) BE0003602 Protein S100-A2 (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00768 Olopatadine Drug2 : DB00792 Tripelennamine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0001090 Protein S100-A1 (-1) BE0001206 Protein S100-A12 (-1) BE0003602 Protein S100-A2 (-1) --------------------------------------------------- Drug1 : DB00768 Olopatadine Drug2 : DB00835 Brompheniramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0001090 Protein S100-A1 (-1) BE0001206 Protein S100-A12 (-1) BE0003602 Protein S100-A2 (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00768 Olopatadine Drug2 : DB00902 Methdilazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0001090 Protein S100-A1 (-1) BE0001206 Protein S100-A12 (-1) BE0003602 Protein S100-A2 (-1) --------------------------------------------------- Drug1 : DB00768 Olopatadine Drug2 : DB00950 Fexofenadine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0001090 Protein S100-A1 (-1) BE0001206 Protein S100-A12 (-1) BE0003602 Protein S100-A2 (-1) --------------------------------------------------- Drug1 : DB00768 Olopatadine Drug2 : DB00967 Desloratadine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0001090 Protein S100-A1 (-1) BE0001206 Protein S100-A12 (-1) BE0003602 Protein S100-A2 (-1) --------------------------------------------------- Drug1 : DB00768 Olopatadine Drug2 : DB00972 Azelastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0001090 Protein S100-A1 (-1) BE0001206 Protein S100-A12 (-1) BE0003602 Protein S100-A2 (-1) --------------------------------------------------- Drug1 : DB00768 Olopatadine Drug2 : DB00985 Dimenhydrinate Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0001090 Protein S100-A1 (-1) BE0001206 Protein S100-A12 (-1) BE0003602 Protein S100-A2 (-1) --------------------------------------------------- Drug1 : DB00768 Olopatadine Drug2 : DB01069 Promethazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0001090 Protein S100-A1 (-1) BE0001206 Protein S100-A12 (-1) BE0003602 Protein S100-A2 (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00768 Olopatadine Drug2 : DB01071 Mequitazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0001090 Protein S100-A1 (-1) BE0001206 Protein S100-A12 (-1) BE0003602 Protein S100-A2 (-1) --------------------------------------------------- Drug1 : DB00768 Olopatadine Drug2 : DB01075 Diphenhydramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0001090 Protein S100-A1 (-1) BE0001206 Protein S100-A12 (-1) BE0003602 Protein S100-A2 (-1) --------------------------------------------------- Drug1 : DB00768 Olopatadine Drug2 : DB01084 Emedastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0001090 Protein S100-A1 (-1) BE0001206 Protein S100-A12 (-1) BE0003602 Protein S100-A2 (-1) --------------------------------------------------- Drug1 : DB00768 Olopatadine Drug2 : DB01106 Levocabastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0001090 Protein S100-A1 (-1) BE0001206 Protein S100-A12 (-1) BE0003602 Protein S100-A2 (-1) Non-common off-target(s) (drug2) : BE0000464 Neurotensin receptor type 2 (-1) --------------------------------------------------- Drug1 : DB00768 Olopatadine Drug2 : DB01114 Chlorphenamine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0001090 Protein S100-A1 (-1) BE0001206 Protein S100-A12 (-1) BE0003602 Protein S100-A2 (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB00768 Olopatadine Drug2 : DB01146 Diphenylpyraline Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0001090 Protein S100-A1 (-1) BE0001206 Protein S100-A12 (-1) BE0003602 Protein S100-A2 (-1) Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB00768 Olopatadine Drug2 : DB01176 Cyclizine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0001090 Protein S100-A1 (-1) BE0001206 Protein S100-A12 (-1) BE0003602 Protein S100-A2 (-1) Non-common off-target(s) (drug2) : BE0000951 Estrogen sulfotransferase (-1) --------------------------------------------------- Drug1 : DB00768 Olopatadine Drug2 : DB01237 Bromodiphenhydramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0001090 Protein S100-A1 (-1) BE0001206 Protein S100-A12 (-1) BE0003602 Protein S100-A2 (-1) --------------------------------------------------- Drug1 : DB00768 Olopatadine Drug2 : DB01246 Alimemazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0001090 Protein S100-A1 (-1) BE0001206 Protein S100-A12 (-1) BE0003602 Protein S100-A2 (-1) --------------------------------------------------- Drug1 : DB00768 Olopatadine Drug2 : DB01615 Aceprometazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0001090 Protein S100-A1 (-1) BE0001206 Protein S100-A12 (-1) BE0003602 Protein S100-A2 (-1) --------------------------------------------------- Drug1 : DB00768 Olopatadine Drug2 : DB01619 Phenindamine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0001090 Protein S100-A1 (-1) BE0001206 Protein S100-A12 (-1) BE0003602 Protein S100-A2 (-1) --------------------------------------------------- Drug1 : DB00768 Olopatadine Drug2 : DB01620 Pheniramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0001090 Protein S100-A1 (-1) BE0001206 Protein S100-A12 (-1) BE0003602 Protein S100-A2 (-1) --------------------------------------------------- Drug1 : DB00768 Olopatadine Drug2 : DB04837 Clofedanol Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0001090 Protein S100-A1 (-1) BE0001206 Protein S100-A12 (-1) BE0003602 Protein S100-A2 (-1) --------------------------------------------------- Drug1 : DB00768 Olopatadine Drug2 : DB04890 Bepotastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0001090 Protein S100-A1 (-1) BE0001206 Protein S100-A12 (-1) BE0003602 Protein S100-A2 (-1) --------------------------------------------------- Drug1 : DB00768 Olopatadine Drug2 : DB06691 Mepyramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0001090 Protein S100-A1 (-1) BE0001206 Protein S100-A12 (-1) BE0003602 Protein S100-A2 (-1) --------------------------------------------------- Drug1 : DB00768 Olopatadine Drug2 : DB08799 Antazoline Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0001090 Protein S100-A1 (-1) BE0001206 Protein S100-A12 (-1) BE0003602 Protein S100-A2 (-1) --------------------------------------------------- Drug1 : DB00768 Olopatadine Drug2 : DB08800 Chloropyramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0001090 Protein S100-A1 (-1) BE0001206 Protein S100-A12 (-1) BE0003602 Protein S100-A2 (-1) --------------------------------------------------- Drug1 : DB00768 Olopatadine Drug2 : DB08801 Dimetindene Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0001090 Protein S100-A1 (-1) BE0001206 Protein S100-A12 (-1) BE0003602 Protein S100-A2 (-1) Non-common off-target(s) (drug2) : BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00768 Olopatadine Drug2 : DB08802 Isothipendyl Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0001090 Protein S100-A1 (-1) BE0001206 Protein S100-A12 (-1) BE0003602 Protein S100-A2 (-1) --------------------------------------------------- Drug1 : DB00768 Olopatadine Drug2 : DB08936 Chlorcyclizine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0001090 Protein S100-A1 (-1) BE0001206 Protein S100-A12 (-1) BE0003602 Protein S100-A2 (-1) --------------------------------------------------- Drug1 : DB00769 Hydrocortamate Drug2 : DB00838 Clocortolone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00769 Hydrocortamate Drug2 : DB00846 Flurandrenolide Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00769 Hydrocortamate Drug2 : DB00860 Prednisolone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00769 Hydrocortamate Drug2 : DB00873 Loteprednol Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00769 Hydrocortamate Drug2 : DB00896 Rimexolone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00769 Hydrocortamate Drug2 : DB00959 Methylprednisolone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00769 Hydrocortamate Drug2 : DB01013 Clobetasol propionate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00769 Hydrocortamate Drug2 : DB01047 Fluocinonide Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug2) : BE0004659 Smoothened homolog (1) --------------------------------------------------- Drug1 : DB00769 Hydrocortamate Drug2 : DB01130 Prednicarbate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00769 Hydrocortamate Drug2 : DB01234 Dexamethasone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug2) : BE0000005 Nitric oxide synthase, inducible (-1) BE0000422 Annexin A1 (1) BE0000074 Nuclear receptor subfamily 0 group B member 1 (1) --------------------------------------------------- Drug1 : DB00769 Hydrocortamate Drug2 : DB01260 Desonide Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00769 Hydrocortamate Drug2 : DB01380 Cortisone acetate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00769 Hydrocortamate Drug2 : DB01384 Paramethasone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00769 Hydrocortamate Drug2 : DB01410 Ciclesonide Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00769 Hydrocortamate Drug2 : DB06781 Difluprednate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00769 Hydrocortamate Drug2 : DB08906 Fluticasone furoate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00770 Alprostadil Drug2 : DB00917 Dinoprostone Pharmacological target (+,+) : BE0000064 Prostaglandin E2 receptor EP1 subtype Pharmacological target (+,+) : BE0000368 Prostaglandin E2 receptor EP2 subtype Non-common off-target(s) (drug2) : BE0002375 Prostaglandin E2 receptor EP3 subtype (1) BE0003522 Prostaglandin E2 receptor EP4 subtype (1) --------------------------------------------------- Drug1 : DB00770 Alprostadil Drug2 : DB00929 Misoprostol Pharmacological target (+,+) : BE0000368 Prostaglandin E2 receptor EP2 subtype Non-common off-target(s) (drug1) : BE0000064 Prostaglandin E2 receptor EP1 subtype (1) Non-common off-target(s) (drug2) : BE0002375 Prostaglandin E2 receptor EP3 subtype (1) BE0003522 Prostaglandin E2 receptor EP4 subtype (1) --------------------------------------------------- Drug1 : DB00770 Alprostadil Drug2 : DB01088 Iloprost Pharmacological target (+,+) : BE0000064 Prostaglandin E2 receptor EP1 subtype Non-common off-target(s) (drug1) : BE0000368 Prostaglandin E2 receptor EP2 subtype (1) Non-common off-target(s) (drug2) : BE0000487 cAMP-specific 3',5'-cyclic phosphodiesterase 4B (1) BE0001287 cAMP-specific 3',5'-cyclic phosphodiesterase 4D (1) BE0001133 cAMP-specific 3',5'-cyclic phosphodiesterase 4A (1) BE0000475 Prostacyclin receptor (1) BE0002353 cAMP-specific 3',5'-cyclic phosphodiesterase 4C (1) --------------------------------------------------- Drug1 : DB00771 Clidinium Drug2 : DB00782 Propantheline Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 --------------------------------------------------- Drug1 : DB00771 Clidinium Drug2 : DB00804 Dicyclomine Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug2) : BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00771 Clidinium Drug2 : DB00810 Biperiden Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug2) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) --------------------------------------------------- Drug1 : DB00771 Clidinium Drug2 : DB00942 Cycrimine Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 --------------------------------------------------- Drug1 : DB00771 Clidinium Drug2 : DB00979 Cyclopentolate Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 --------------------------------------------------- Drug1 : DB00771 Clidinium Drug2 : DB00986 Glycopyrrolate Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) --------------------------------------------------- Drug1 : DB00771 Clidinium Drug2 : DB01148 Flavoxate Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug2) : BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00771 Clidinium Drug2 : DB04843 Mepenzolate Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) --------------------------------------------------- Drug1 : DB00772 Malathion Drug2 : DB00941 Hexafluronium Pharmacological target (-,-) : BE0002180 Cholinesterase --------------------------------------------------- Drug1 : DB00772 Malathion Drug2 : DB00989 Rivastigmine Pharmacological target (-,-) : BE0002180 Cholinesterase Non-common off-target(s) (drug2) : BE0000426 Acetylcholinesterase (-1) --------------------------------------------------- Drug1 : DB00772 Malathion Drug2 : DB01010 Edrophonium Pharmacological target (-,-) : BE0002180 Cholinesterase Non-common off-target(s) (drug2) : BE0000426 Acetylcholinesterase (-1) --------------------------------------------------- Drug1 : DB00772 Malathion Drug2 : DB01057 Echothiophate Pharmacological target (-,-) : BE0002180 Cholinesterase --------------------------------------------------- Drug1 : DB00773 Etoposide Drug2 : DB00997 Doxorubicin Pharmacological target (-,-) : BE0000742 DNA topoisomerase 2-alpha Non-common off-target(s) (drug1) : BE0002425 DNA topoisomerase 2-beta (-1) --------------------------------------------------- Drug1 : DB00773 Etoposide Drug2 : DB01137 Levofloxacin Pharmacological target (-,-) : BE0000742 DNA topoisomerase 2-alpha Non-common off-target(s) (drug1) : BE0002425 DNA topoisomerase 2-beta (-1) --------------------------------------------------- Drug1 : DB00773 Etoposide Drug2 : DB01177 Idarubicin Pharmacological target (-,-) : BE0000742 DNA topoisomerase 2-alpha Non-common off-target(s) (drug1) : BE0002425 DNA topoisomerase 2-beta (-1) --------------------------------------------------- Drug1 : DB00773 Etoposide Drug2 : DB01204 Mitoxantrone Pharmacological target (-,-) : BE0000742 DNA topoisomerase 2-alpha Non-common off-target(s) (drug1) : BE0002425 DNA topoisomerase 2-beta (-1) --------------------------------------------------- Drug1 : DB00773 Etoposide Drug2 : DB01208 Sparfloxacin Pharmacological target (-,-) : BE0000742 DNA topoisomerase 2-alpha Non-common off-target(s) (drug1) : BE0002425 DNA topoisomerase 2-beta (-1) --------------------------------------------------- Drug1 : DB00773 Etoposide Drug2 : DB04576 Fleroxacin Pharmacological target (-,-) : BE0000742 DNA topoisomerase 2-alpha Non-common off-target(s) (drug1) : BE0002425 DNA topoisomerase 2-beta (-1) --------------------------------------------------- Drug1 : DB00773 Etoposide Drug2 : DB09047 Finafloxacin Pharmacological target (-,-) : BE0000742 DNA topoisomerase 2-alpha Non-common off-target(s) (drug1) : BE0002425 DNA topoisomerase 2-beta (-1) --------------------------------------------------- Drug1 : DB00774 Hydroflumethiazide Drug2 : DB00903 Ethacrynic acid Pharmacological target (-,-) : BE0000502 Solute carrier family 12 member 1 Non-common off-target(s) (drug1) : BE0000267 Carbonic anhydrase 1 (-1) BE0000322 Carbonic anhydrase 2 (-1) BE0000535 Carbonic anhydrase 4 (-1) BE0002437 Carbonic anhydrase 9 (-1) BE0001653 Carbonic anhydrase 12 (-1) Non-common off-target(s) (drug2) : BE0000732 Sodium/potassium-transporting ATPase subunit alpha-1 (-1) --------------------------------------------------- Drug1 : DB00776 Oxcarbazepine Drug2 : DB00908 Quinidine Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug2) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000154 Potassium channel subfamily K member 1 (-1) BE0000680 Potassium channel subfamily K member 6 (-1) --------------------------------------------------- Drug1 : DB00776 Oxcarbazepine Drug2 : DB01056 Tocainide Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha --------------------------------------------------- Drug1 : DB00776 Oxcarbazepine Drug2 : DB01182 Propafenone Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug2) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) --------------------------------------------------- Drug1 : DB00776 Oxcarbazepine Drug2 : DB01195 Flecainide Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug2) : BE0002083 Sodium channel protein type 4 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00776 Oxcarbazepine Drug2 : DB01228 Encainide Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha --------------------------------------------------- Drug1 : DB00776 Oxcarbazepine Drug2 : DB01320 Fosphenytoin Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha --------------------------------------------------- Drug1 : DB00776 Oxcarbazepine Drug2 : DB01426 Ajmaline Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha --------------------------------------------------- Drug1 : DB00776 Oxcarbazepine Drug2 : DB01429 Aprindine Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug2) : BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00777 Propiomazine Drug2 : DB00792 Tripelennamine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00777 Propiomazine Drug2 : DB00902 Methdilazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00777 Propiomazine Drug2 : DB00950 Fexofenadine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00777 Propiomazine Drug2 : DB00967 Desloratadine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00777 Propiomazine Drug2 : DB00972 Azelastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00777 Propiomazine Drug2 : DB00985 Dimenhydrinate Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00777 Propiomazine Drug2 : DB01071 Mequitazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00777 Propiomazine Drug2 : DB01075 Diphenhydramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00777 Propiomazine Drug2 : DB01084 Emedastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00777 Propiomazine Drug2 : DB01106 Levocabastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) Non-common off-target(s) (drug2) : BE0000464 Neurotensin receptor type 2 (-1) --------------------------------------------------- Drug1 : DB00777 Propiomazine Drug2 : DB01114 Chlorphenamine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB00777 Propiomazine Drug2 : DB01146 Diphenylpyraline Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB00777 Propiomazine Drug2 : DB01176 Cyclizine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) Non-common off-target(s) (drug2) : BE0000951 Estrogen sulfotransferase (-1) --------------------------------------------------- Drug1 : DB00777 Propiomazine Drug2 : DB01237 Bromodiphenhydramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00777 Propiomazine Drug2 : DB01246 Alimemazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00777 Propiomazine Drug2 : DB01615 Aceprometazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00777 Propiomazine Drug2 : DB01619 Phenindamine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00777 Propiomazine Drug2 : DB01620 Pheniramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00777 Propiomazine Drug2 : DB04837 Clofedanol Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00777 Propiomazine Drug2 : DB04890 Bepotastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00777 Propiomazine Drug2 : DB06691 Mepyramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00777 Propiomazine Drug2 : DB08799 Antazoline Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00777 Propiomazine Drug2 : DB08800 Chloropyramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00777 Propiomazine Drug2 : DB08802 Isothipendyl Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00777 Propiomazine Drug2 : DB08936 Chlorcyclizine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00780 Phenelzine Drug2 : DB01171 Moclobemide Pharmacological target (-,-) : BE0002198 Amine oxidase [flavin-containing] A Non-common off-target(s) (drug1) : BE0000253 4-aminobutyrate aminotransferase, mitochondrial (-1) BE0000667 Alanine aminotransferase 1 (-1) BE0002166 Alanine aminotransferase 2 (-1) BE0002173 Glutamic acid decarboxylase (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0001002 Membrane primary amine oxidase (-1) --------------------------------------------------- Drug1 : DB00780 Phenelzine Drug2 : DB01247 Isocarboxazid Pharmacological target (-,-) : BE0002196 Amine oxidase [flavin-containing] B Pharmacological target (-,-) : BE0002198 Amine oxidase [flavin-containing] A Non-common off-target(s) (drug1) : BE0000253 4-aminobutyrate aminotransferase, mitochondrial (-1) BE0000667 Alanine aminotransferase 1 (-1) BE0002166 Alanine aminotransferase 2 (-1) BE0002173 Glutamic acid decarboxylase (-1) BE0001002 Membrane primary amine oxidase (-1) --------------------------------------------------- Drug1 : DB00780 Phenelzine Drug2 : DB01367 Rasagiline Pharmacological target (-,-) : BE0002196 Amine oxidase [flavin-containing] B Non-common off-target(s) (drug1) : BE0000253 4-aminobutyrate aminotransferase, mitochondrial (-1) BE0000667 Alanine aminotransferase 1 (-1) BE0002166 Alanine aminotransferase 2 (-1) BE0002173 Glutamic acid decarboxylase (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0001002 Membrane primary amine oxidase (-1) Non-common off-target(s) (drug2) : BE0000246 Apoptosis regulator Bcl-2 (1) --------------------------------------------------- Drug1 : DB00782 Propantheline Drug2 : DB00804 Dicyclomine Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug2) : BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00782 Propantheline Drug2 : DB00810 Biperiden Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug2) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) --------------------------------------------------- Drug1 : DB00782 Propantheline Drug2 : DB00942 Cycrimine Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 --------------------------------------------------- Drug1 : DB00782 Propantheline Drug2 : DB00979 Cyclopentolate Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 --------------------------------------------------- Drug1 : DB00782 Propantheline Drug2 : DB00986 Glycopyrrolate Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) --------------------------------------------------- Drug1 : DB00782 Propantheline Drug2 : DB01148 Flavoxate Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug2) : BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00782 Propantheline Drug2 : DB04843 Mepenzolate Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) --------------------------------------------------- Drug1 : DB00783 Estradiol Drug2 : DB00823 Ethynodiol Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug1) : BE0000792 Estrogen receptor beta (1) Non-common off-target(s) (drug2) : BE0000557 Progesterone receptor (1) --------------------------------------------------- Drug1 : DB00783 Estradiol Drug2 : DB00890 Dienestrol Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug1) : BE0000792 Estrogen receptor beta (1) --------------------------------------------------- Drug1 : DB00783 Estradiol Drug2 : DB00957 Norgestimate Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug1) : BE0000792 Estrogen receptor beta (1) Non-common off-target(s) (drug2) : BE0000557 Progesterone receptor (1) --------------------------------------------------- Drug1 : DB00783 Estradiol Drug2 : DB00977 Ethinyl Estradiol Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug1) : BE0000792 Estrogen receptor beta (1) Non-common off-target(s) (drug2) : BE0000956 Nuclear receptor subfamily 1 group I member 2 (1) --------------------------------------------------- Drug1 : DB00783 Estradiol Drug2 : DB01357 Mestranol Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug1) : BE0000792 Estrogen receptor beta (1) --------------------------------------------------- Drug1 : DB00783 Estradiol Drug2 : DB04575 Quinestrol Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug1) : BE0000792 Estrogen receptor beta (1) --------------------------------------------------- Drug1 : DB00784 Mefenamic acid Drug2 : DB01050 Ibuprofen Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) Non-common off-target(s) (drug2) : BE0001088 Tissue-type plasminogen activator (-1) BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0001195 Cystic fibrosis transmembrane conductance regulator (-1) --------------------------------------------------- Drug1 : DB00784 Mefenamic acid Drug2 : DB01628 Etoricoxib Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) --------------------------------------------------- Drug1 : DB00784 Mefenamic acid Drug2 : DB04552 Niflumic Acid Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) Non-common off-target(s) (drug2) : BE0003997 Phospholipase A2 (-1) BE0002376 Chloride channel protein ClC-Ka (1) --------------------------------------------------- Drug1 : DB00784 Mefenamic acid Drug2 : DB04743 Nimesulide Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) --------------------------------------------------- Drug1 : DB00785 Cryptenamine Drug2 : DB01036 Tolterodine Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Pharmacological target (-,-) : BE0000405 Muscarinic acetylcholine receptor M4 Pharmacological target (-,-) : BE0000247 Muscarinic acetylcholine receptor M5 --------------------------------------------------- Drug1 : DB00785 Cryptenamine Drug2 : DB01062 Oxybutynin Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00785 Cryptenamine Drug2 : DB01231 Diphenidol Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00785 Cryptenamine Drug2 : DB08897 Aclidinium Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Pharmacological target (-,-) : BE0000405 Muscarinic acetylcholine receptor M4 Pharmacological target (-,-) : BE0000247 Muscarinic acetylcholine receptor M5 --------------------------------------------------- Drug1 : DB00788 Naproxen Drug2 : DB00795 Sulfasalazine Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug2) : BE0000030 Cystine/glutamate transporter (-1) BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0000248 Arachidonate 5-lipoxygenase (-1) BE0004655 Inhibitor of nuclear factor kappa-B kinase subunit alpha (-1) BE0001154 Inhibitor of nuclear factor kappa-B kinase subunit beta (-1) BE0000069 Acetyl-CoA acetyltransferase, mitochondrial (-1) BE0001893 Thromboxane-A synthase (-1) BE0003997 Phospholipase A2 (-1) --------------------------------------------------- Drug1 : DB00788 Naproxen Drug2 : DB00812 Phenylbutazone Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug2) : BE0000117 Prostacyclin synthase (-1) --------------------------------------------------- Drug1 : DB00788 Naproxen Drug2 : DB00870 Suprofen Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 --------------------------------------------------- Drug1 : DB00788 Naproxen Drug2 : DB00936 Salicylic acid Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug2) : BE0000126 Aldo-keto reductase family 1 member C1 (-1) --------------------------------------------------- Drug1 : DB00788 Naproxen Drug2 : DB00939 Meclofenamic acid Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug2) : BE0000248 Arachidonate 5-lipoxygenase (-1) --------------------------------------------------- Drug1 : DB00788 Naproxen Drug2 : DB00945 Acetylsalicylic acid Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug2) : BE0000126 Aldo-keto reductase family 1 member C1 (-1) BE0004907 5'-AMP-activated protein kinase (1) BE0004903 Nuclear factor NF-kappa-B (-1) --------------------------------------------------- Drug1 : DB00788 Naproxen Drug2 : DB00991 Oxaprozin Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 --------------------------------------------------- Drug1 : DB00788 Naproxen Drug2 : DB01014 Balsalazide Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug2) : BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0000248 Arachidonate 5-lipoxygenase (-1) --------------------------------------------------- Drug1 : DB00788 Naproxen Drug2 : DB01050 Ibuprofen Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) Non-common off-target(s) (drug2) : BE0001088 Tissue-type plasminogen activator (-1) BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0001195 Cystic fibrosis transmembrane conductance regulator (-1) --------------------------------------------------- Drug1 : DB00788 Naproxen Drug2 : DB01283 Lumiracoxib Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 --------------------------------------------------- Drug1 : DB00788 Naproxen Drug2 : DB01397 Magnesium salicylate Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 --------------------------------------------------- Drug1 : DB00788 Naproxen Drug2 : DB01398 Salicylate-sodium Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 --------------------------------------------------- Drug1 : DB00788 Naproxen Drug2 : DB01399 Salsalate Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 --------------------------------------------------- Drug1 : DB00788 Naproxen Drug2 : DB01600 Tiaprofenic acid Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 --------------------------------------------------- Drug1 : DB00788 Naproxen Drug2 : DB01628 Etoricoxib Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) --------------------------------------------------- Drug1 : DB00788 Naproxen Drug2 : DB04552 Niflumic Acid Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) Non-common off-target(s) (drug2) : BE0003997 Phospholipase A2 (-1) BE0002376 Chloride channel protein ClC-Ka (1) --------------------------------------------------- Drug1 : DB00788 Naproxen Drug2 : DB04743 Nimesulide Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) --------------------------------------------------- Drug1 : DB00788 Naproxen Drug2 : DB06725 Lornoxicam Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 --------------------------------------------------- Drug1 : DB00790 Perindopril Drug2 : DB00881 Quinapril Pharmacological target (-,-) : BE0000221 Angiotensin-converting enzyme --------------------------------------------------- Drug1 : DB00790 Perindopril Drug2 : DB01180 Rescinnamine Pharmacological target (-,-) : BE0000221 Angiotensin-converting enzyme --------------------------------------------------- Drug1 : DB00790 Perindopril Drug2 : DB01197 Captopril Pharmacological target (-,-) : BE0000221 Angiotensin-converting enzyme Non-common off-target(s) (drug2) : BE0000642 72 kDa type IV collagenase (-1) BE0000058 Matrix metalloproteinase-9 (-1) --------------------------------------------------- Drug1 : DB00790 Perindopril Drug2 : DB01340 Cilazapril Pharmacological target (-,-) : BE0000221 Angiotensin-converting enzyme --------------------------------------------------- Drug1 : DB00790 Perindopril Drug2 : DB01348 Spirapril Pharmacological target (-,-) : BE0000221 Angiotensin-converting enzyme --------------------------------------------------- Drug1 : DB00792 Tripelennamine Drug2 : DB00835 Brompheniramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00792 Tripelennamine Drug2 : DB00902 Methdilazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00792 Tripelennamine Drug2 : DB00950 Fexofenadine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00792 Tripelennamine Drug2 : DB00967 Desloratadine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00792 Tripelennamine Drug2 : DB00972 Azelastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00792 Tripelennamine Drug2 : DB00985 Dimenhydrinate Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00792 Tripelennamine Drug2 : DB01069 Promethazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00792 Tripelennamine Drug2 : DB01071 Mequitazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00792 Tripelennamine Drug2 : DB01075 Diphenhydramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00792 Tripelennamine Drug2 : DB01084 Emedastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00792 Tripelennamine Drug2 : DB01106 Levocabastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000464 Neurotensin receptor type 2 (-1) --------------------------------------------------- Drug1 : DB00792 Tripelennamine Drug2 : DB01114 Chlorphenamine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB00792 Tripelennamine Drug2 : DB01146 Diphenylpyraline Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB00792 Tripelennamine Drug2 : DB01176 Cyclizine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000951 Estrogen sulfotransferase (-1) --------------------------------------------------- Drug1 : DB00792 Tripelennamine Drug2 : DB01237 Bromodiphenhydramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00792 Tripelennamine Drug2 : DB01246 Alimemazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00792 Tripelennamine Drug2 : DB01615 Aceprometazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00792 Tripelennamine Drug2 : DB01619 Phenindamine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00792 Tripelennamine Drug2 : DB01620 Pheniramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00792 Tripelennamine Drug2 : DB04837 Clofedanol Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00792 Tripelennamine Drug2 : DB04890 Bepotastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00792 Tripelennamine Drug2 : DB06691 Mepyramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00792 Tripelennamine Drug2 : DB08799 Antazoline Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00792 Tripelennamine Drug2 : DB08800 Chloropyramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00792 Tripelennamine Drug2 : DB08801 Dimetindene Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00792 Tripelennamine Drug2 : DB08802 Isothipendyl Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00792 Tripelennamine Drug2 : DB08936 Chlorcyclizine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00794 Primidone Drug2 : DB01198 Zopiclone Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0004797 GABA-A receptor (anion channel) (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0000736 Translocator protein (1) --------------------------------------------------- Drug1 : DB00794 Primidone Drug2 : DB01544 Flunitrazepam Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0004797 GABA-A receptor (anion channel) (1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) Non-common off-target(s) (drug2) : BE0000736 Translocator protein (1) --------------------------------------------------- Drug1 : DB00795 Sulfasalazine Drug2 : DB00812 Phenylbutazone Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000030 Cystine/glutamate transporter (-1) BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0000248 Arachidonate 5-lipoxygenase (-1) BE0004655 Inhibitor of nuclear factor kappa-B kinase subunit alpha (-1) BE0001154 Inhibitor of nuclear factor kappa-B kinase subunit beta (-1) BE0000069 Acetyl-CoA acetyltransferase, mitochondrial (-1) BE0001893 Thromboxane-A synthase (-1) BE0003997 Phospholipase A2 (-1) Non-common off-target(s) (drug2) : BE0000117 Prostacyclin synthase (-1) --------------------------------------------------- Drug1 : DB00795 Sulfasalazine Drug2 : DB00870 Suprofen Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000030 Cystine/glutamate transporter (-1) BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0000248 Arachidonate 5-lipoxygenase (-1) BE0004655 Inhibitor of nuclear factor kappa-B kinase subunit alpha (-1) BE0001154 Inhibitor of nuclear factor kappa-B kinase subunit beta (-1) BE0000069 Acetyl-CoA acetyltransferase, mitochondrial (-1) BE0001893 Thromboxane-A synthase (-1) BE0003997 Phospholipase A2 (-1) --------------------------------------------------- Drug1 : DB00795 Sulfasalazine Drug2 : DB00936 Salicylic acid Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000030 Cystine/glutamate transporter (-1) BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0000248 Arachidonate 5-lipoxygenase (-1) BE0004655 Inhibitor of nuclear factor kappa-B kinase subunit alpha (-1) BE0001154 Inhibitor of nuclear factor kappa-B kinase subunit beta (-1) BE0000069 Acetyl-CoA acetyltransferase, mitochondrial (-1) BE0001893 Thromboxane-A synthase (-1) BE0003997 Phospholipase A2 (-1) Non-common off-target(s) (drug2) : BE0000126 Aldo-keto reductase family 1 member C1 (-1) --------------------------------------------------- Drug1 : DB00795 Sulfasalazine Drug2 : DB00939 Meclofenamic acid Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Pharmacological target (-,-) : BE0000248 Arachidonate 5-lipoxygenase Non-common off-target(s) (drug1) : BE0000030 Cystine/glutamate transporter (-1) BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0004655 Inhibitor of nuclear factor kappa-B kinase subunit alpha (-1) BE0001154 Inhibitor of nuclear factor kappa-B kinase subunit beta (-1) BE0000069 Acetyl-CoA acetyltransferase, mitochondrial (-1) BE0001893 Thromboxane-A synthase (-1) BE0003997 Phospholipase A2 (-1) --------------------------------------------------- Drug1 : DB00795 Sulfasalazine Drug2 : DB00945 Acetylsalicylic acid Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000030 Cystine/glutamate transporter (-1) BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0000248 Arachidonate 5-lipoxygenase (-1) BE0004655 Inhibitor of nuclear factor kappa-B kinase subunit alpha (-1) BE0001154 Inhibitor of nuclear factor kappa-B kinase subunit beta (-1) BE0000069 Acetyl-CoA acetyltransferase, mitochondrial (-1) BE0001893 Thromboxane-A synthase (-1) BE0003997 Phospholipase A2 (-1) Non-common off-target(s) (drug2) : BE0000126 Aldo-keto reductase family 1 member C1 (-1) BE0004907 5'-AMP-activated protein kinase (1) BE0004903 Nuclear factor NF-kappa-B (-1) --------------------------------------------------- Drug1 : DB00795 Sulfasalazine Drug2 : DB00991 Oxaprozin Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000030 Cystine/glutamate transporter (-1) BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0000248 Arachidonate 5-lipoxygenase (-1) BE0004655 Inhibitor of nuclear factor kappa-B kinase subunit alpha (-1) BE0001154 Inhibitor of nuclear factor kappa-B kinase subunit beta (-1) BE0000069 Acetyl-CoA acetyltransferase, mitochondrial (-1) BE0001893 Thromboxane-A synthase (-1) BE0003997 Phospholipase A2 (-1) --------------------------------------------------- Drug1 : DB00795 Sulfasalazine Drug2 : DB01014 Balsalazide Pharmacological target (+,+) : BE0000215 Peroxisome proliferator-activated receptor gamma Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Pharmacological target (-,-) : BE0000248 Arachidonate 5-lipoxygenase Non-common off-target(s) (drug1) : BE0000030 Cystine/glutamate transporter (-1) BE0004655 Inhibitor of nuclear factor kappa-B kinase subunit alpha (-1) BE0001154 Inhibitor of nuclear factor kappa-B kinase subunit beta (-1) BE0000069 Acetyl-CoA acetyltransferase, mitochondrial (-1) BE0001893 Thromboxane-A synthase (-1) BE0003997 Phospholipase A2 (-1) --------------------------------------------------- Drug1 : DB00795 Sulfasalazine Drug2 : DB01283 Lumiracoxib Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000030 Cystine/glutamate transporter (-1) BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0000248 Arachidonate 5-lipoxygenase (-1) BE0004655 Inhibitor of nuclear factor kappa-B kinase subunit alpha (-1) BE0001154 Inhibitor of nuclear factor kappa-B kinase subunit beta (-1) BE0000069 Acetyl-CoA acetyltransferase, mitochondrial (-1) BE0001893 Thromboxane-A synthase (-1) BE0003997 Phospholipase A2 (-1) --------------------------------------------------- Drug1 : DB00795 Sulfasalazine Drug2 : DB01397 Magnesium salicylate Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000030 Cystine/glutamate transporter (-1) BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0000248 Arachidonate 5-lipoxygenase (-1) BE0004655 Inhibitor of nuclear factor kappa-B kinase subunit alpha (-1) BE0001154 Inhibitor of nuclear factor kappa-B kinase subunit beta (-1) BE0000069 Acetyl-CoA acetyltransferase, mitochondrial (-1) BE0001893 Thromboxane-A synthase (-1) BE0003997 Phospholipase A2 (-1) --------------------------------------------------- Drug1 : DB00795 Sulfasalazine Drug2 : DB01398 Salicylate-sodium Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000030 Cystine/glutamate transporter (-1) BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0000248 Arachidonate 5-lipoxygenase (-1) BE0004655 Inhibitor of nuclear factor kappa-B kinase subunit alpha (-1) BE0001154 Inhibitor of nuclear factor kappa-B kinase subunit beta (-1) BE0000069 Acetyl-CoA acetyltransferase, mitochondrial (-1) BE0001893 Thromboxane-A synthase (-1) BE0003997 Phospholipase A2 (-1) --------------------------------------------------- Drug1 : DB00795 Sulfasalazine Drug2 : DB01399 Salsalate Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000030 Cystine/glutamate transporter (-1) BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0000248 Arachidonate 5-lipoxygenase (-1) BE0004655 Inhibitor of nuclear factor kappa-B kinase subunit alpha (-1) BE0001154 Inhibitor of nuclear factor kappa-B kinase subunit beta (-1) BE0000069 Acetyl-CoA acetyltransferase, mitochondrial (-1) BE0001893 Thromboxane-A synthase (-1) BE0003997 Phospholipase A2 (-1) --------------------------------------------------- Drug1 : DB00795 Sulfasalazine Drug2 : DB01600 Tiaprofenic acid Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000030 Cystine/glutamate transporter (-1) BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0000248 Arachidonate 5-lipoxygenase (-1) BE0004655 Inhibitor of nuclear factor kappa-B kinase subunit alpha (-1) BE0001154 Inhibitor of nuclear factor kappa-B kinase subunit beta (-1) BE0000069 Acetyl-CoA acetyltransferase, mitochondrial (-1) BE0001893 Thromboxane-A synthase (-1) BE0003997 Phospholipase A2 (-1) --------------------------------------------------- Drug1 : DB00795 Sulfasalazine Drug2 : DB06725 Lornoxicam Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000030 Cystine/glutamate transporter (-1) BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0000248 Arachidonate 5-lipoxygenase (-1) BE0004655 Inhibitor of nuclear factor kappa-B kinase subunit alpha (-1) BE0001154 Inhibitor of nuclear factor kappa-B kinase subunit beta (-1) BE0000069 Acetyl-CoA acetyltransferase, mitochondrial (-1) BE0001893 Thromboxane-A synthase (-1) BE0003997 Phospholipase A2 (-1) --------------------------------------------------- Drug1 : DB00796 Candesartan Drug2 : DB00876 Eprosartan Pharmacological target (-,-) : BE0000062 Type-1 angiotensin II receptor --------------------------------------------------- Drug1 : DB00796 Candesartan Drug2 : DB00966 Telmisartan Pharmacological target (-,-) : BE0000062 Type-1 angiotensin II receptor Non-common off-target(s) (drug2) : BE0000215 Peroxisome proliferator-activated receptor gamma (1) --------------------------------------------------- Drug1 : DB00796 Candesartan Drug2 : DB01029 Irbesartan Pharmacological target (-,-) : BE0000062 Type-1 angiotensin II receptor --------------------------------------------------- Drug1 : DB00796 Candesartan Drug2 : DB01342 Forasartan Pharmacological target (-,-) : BE0000062 Type-1 angiotensin II receptor --------------------------------------------------- Drug1 : DB00796 Candesartan Drug2 : DB01347 Saprisartan Pharmacological target (-,-) : BE0000062 Type-1 angiotensin II receptor --------------------------------------------------- Drug1 : DB00796 Candesartan Drug2 : DB01349 Tasosartan Pharmacological target (-,-) : BE0000062 Type-1 angiotensin II receptor Non-common off-target(s) (drug2) : BE0003426 Type-2 angiotensin II receptor (-1) --------------------------------------------------- Drug1 : DB00796 Candesartan Drug2 : DB08822 Azilsartan medoxomil Pharmacological target (-,-) : BE0000062 Type-1 angiotensin II receptor --------------------------------------------------- Drug1 : DB00797 Tolazoline Drug2 : DB06207 Silodosin Pharmacological target (-,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000442 Histamine H1 receptor (1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000112 Histamine H2 receptor (1) Non-common off-target(s) (drug2) : BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00799 Tazarotene Drug2 : DB00926 Etretinate Pharmacological target (+,+) : BE0000144 Retinoic acid receptor gamma Pharmacological target (+,+) : BE0000206 Retinoic acid receptor beta Pharmacological target (+,+) : BE0000078 Retinoic acid receptor RXR-beta Pharmacological target (+,+) : BE0000663 Retinoic acid receptor alpha Non-common off-target(s) (drug2) : BE0000707 Retinoic acid receptor RXR-gamma (1) BE0000412 Retinoic acid receptor RXR-alpha (1) --------------------------------------------------- Drug1 : DB00799 Tazarotene Drug2 : DB04942 Tamibarotene Pharmacological target (+,+) : BE0000206 Retinoic acid receptor beta Pharmacological target (+,+) : BE0000663 Retinoic acid receptor alpha Non-common off-target(s) (drug1) : BE0000144 Retinoic acid receptor gamma (1) BE0000078 Retinoic acid receptor RXR-beta (1) --------------------------------------------------- Drug1 : DB00801 Halazepam Drug2 : DB00829 Diazepam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Pharmacological target (+,+) : BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Pharmacological target (+,+) : BE0003596 Gamma-aminobutyric acid receptor subunit pi Pharmacological target (+,+) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Pharmacological target (+,+) : BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 Pharmacological target (+,+) : BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 Non-common off-target(s) (drug2) : BE0000736 Translocator protein (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00801 Halazepam Drug2 : DB00842 Oxazepam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Pharmacological target (+,+) : BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Pharmacological target (+,+) : BE0003596 Gamma-aminobutyric acid receptor subunit pi Pharmacological target (+,+) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Pharmacological target (+,+) : BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 Pharmacological target (+,+) : BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 Non-common off-target(s) (drug2) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00801 Halazepam Drug2 : DB00897 Triazolam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Pharmacological target (+,+) : BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Pharmacological target (+,+) : BE0003596 Gamma-aminobutyric acid receptor subunit pi Pharmacological target (+,+) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Pharmacological target (+,+) : BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 Pharmacological target (+,+) : BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 Non-common off-target(s) (drug2) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00801 Halazepam Drug2 : DB01215 Estazolam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Pharmacological target (+,+) : BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Pharmacological target (+,+) : BE0003596 Gamma-aminobutyric acid receptor subunit pi Pharmacological target (+,+) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Pharmacological target (+,+) : BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 Pharmacological target (+,+) : BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 --------------------------------------------------- Drug1 : DB00801 Halazepam Drug2 : DB01558 Bromazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Pharmacological target (+,+) : BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Pharmacological target (+,+) : BE0003596 Gamma-aminobutyric acid receptor subunit pi Pharmacological target (+,+) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Pharmacological target (+,+) : BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 Pharmacological target (+,+) : BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) Non-common off-target(s) (drug2) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00801 Halazepam Drug2 : DB01559 Clotiazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Pharmacological target (+,+) : BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Pharmacological target (+,+) : BE0003596 Gamma-aminobutyric acid receptor subunit pi Pharmacological target (+,+) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Pharmacological target (+,+) : BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 Pharmacological target (+,+) : BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) --------------------------------------------------- Drug1 : DB00801 Halazepam Drug2 : DB01567 Fludiazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Pharmacological target (+,+) : BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Pharmacological target (+,+) : BE0003596 Gamma-aminobutyric acid receptor subunit pi Pharmacological target (+,+) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Pharmacological target (+,+) : BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 Pharmacological target (+,+) : BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) --------------------------------------------------- Drug1 : DB00801 Halazepam Drug2 : DB01588 Prazepam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Pharmacological target (+,+) : BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Pharmacological target (+,+) : BE0003596 Gamma-aminobutyric acid receptor subunit pi Pharmacological target (+,+) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Pharmacological target (+,+) : BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 Pharmacological target (+,+) : BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 --------------------------------------------------- Drug1 : DB00801 Halazepam Drug2 : DB01589 Quazepam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Pharmacological target (+,+) : BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Pharmacological target (+,+) : BE0003596 Gamma-aminobutyric acid receptor subunit pi Pharmacological target (+,+) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Pharmacological target (+,+) : BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 Pharmacological target (+,+) : BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 Non-common off-target(s) (drug1) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) --------------------------------------------------- Drug1 : DB00801 Halazepam Drug2 : DB01594 Cinolazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Pharmacological target (+,+) : BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Pharmacological target (+,+) : BE0003596 Gamma-aminobutyric acid receptor subunit pi Pharmacological target (+,+) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Pharmacological target (+,+) : BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 Pharmacological target (+,+) : BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) --------------------------------------------------- Drug1 : DB00801 Halazepam Drug2 : DB01595 Nitrazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Pharmacological target (+,+) : BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Pharmacological target (+,+) : BE0003596 Gamma-aminobutyric acid receptor subunit pi Pharmacological target (+,+) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Pharmacological target (+,+) : BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 Pharmacological target (+,+) : BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) Non-common off-target(s) (drug2) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00802 Alfentanil Drug2 : DB00813 Fentanyl Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug2) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) --------------------------------------------------- Drug1 : DB00802 Alfentanil Drug2 : DB00854 Levorphanol Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug2) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) --------------------------------------------------- Drug1 : DB00802 Alfentanil Drug2 : DB00899 Remifentanil Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug2) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) --------------------------------------------------- Drug1 : DB00802 Alfentanil Drug2 : DB00913 Anileridine Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor --------------------------------------------------- Drug1 : DB00802 Alfentanil Drug2 : DB00921 Buprenorphine Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug2) : BE0000632 Kappa-type opioid receptor (-1) BE0000420 Delta-type opioid receptor (-1) --------------------------------------------------- Drug1 : DB00802 Alfentanil Drug2 : DB00956 Hydrocodone Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug2) : BE0000420 Delta-type opioid receptor (1) --------------------------------------------------- Drug1 : DB00802 Alfentanil Drug2 : DB01081 Diphenoxylate Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug2) : BE0000420 Delta-type opioid receptor (1) --------------------------------------------------- Drug1 : DB00802 Alfentanil Drug2 : DB01192 Oxymorphone Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug2) : BE0000420 Delta-type opioid receptor (-1) --------------------------------------------------- Drug1 : DB00802 Alfentanil Drug2 : DB01209 Dezocine Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug2) : BE0000632 Kappa-type opioid receptor (-1) --------------------------------------------------- Drug1 : DB00802 Alfentanil Drug2 : DB01227 Levomethadyl Acetate Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug2) : BE0003585 Neuronal acetylcholine receptor subunit alpha-3 (-1) --------------------------------------------------- Drug1 : DB00802 Alfentanil Drug2 : DB01433 Methadyl Acetate Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor --------------------------------------------------- Drug1 : DB00802 Alfentanil Drug2 : DB01444 Dimethylthiambutene Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug2) : BE0000420 Delta-type opioid receptor (1) --------------------------------------------------- Drug1 : DB00802 Alfentanil Drug2 : DB01452 Heroin Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug2) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) --------------------------------------------------- Drug1 : DB00802 Alfentanil Drug2 : DB01466 Ethylmorphine Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor --------------------------------------------------- Drug1 : DB00802 Alfentanil Drug2 : DB01535 Carfentanil Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug2) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) --------------------------------------------------- Drug1 : DB00802 Alfentanil Drug2 : DB01565 Dihydromorphine Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug2) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) BE0000947 Pro-opiomelanocortin (1) BE0001063 E3 ubiquitin-protein ligase TRIM13 (1) --------------------------------------------------- Drug1 : DB00802 Alfentanil Drug2 : DB06204 Tapentadol Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB00804 Dicyclomine Drug2 : DB00810 Biperiden Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000560 Muscarinic acetylcholine receptor M2 (-1) Non-common off-target(s) (drug2) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) --------------------------------------------------- Drug1 : DB00804 Dicyclomine Drug2 : DB00942 Cycrimine Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00804 Dicyclomine Drug2 : DB00979 Cyclopentolate Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00804 Dicyclomine Drug2 : DB00986 Glycopyrrolate Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000560 Muscarinic acetylcholine receptor M2 (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) --------------------------------------------------- Drug1 : DB00804 Dicyclomine Drug2 : DB04843 Mepenzolate Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000560 Muscarinic acetylcholine receptor M2 (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) --------------------------------------------------- Drug1 : DB00806 Pentoxifylline Drug2 : DB01303 Oxtriphylline Pharmacological target (-,-) : BE0000013 Adenosine receptor A1 Pharmacological target (-,-) : BE0000924 Adenosine receptor A2a Pharmacological target (-,-) : BE0001133 cAMP-specific 3',5'-cyclic phosphodiesterase 4A Non-common off-target(s) (drug1) : BE0000487 cAMP-specific 3',5'-cyclic phosphodiesterase 4B (-1) BE0000182 cGMP-specific 3',5'-cyclic phosphodiesterase (-1) BE0001096 5'-nucleotidase (-1) Non-common off-target(s) (drug2) : BE0002366 Histone deacetylase 2 (1) BE0000436 cGMP-inhibited 3',5'-cyclic phosphodiesterase A (-1) --------------------------------------------------- Drug1 : DB00807 Proparacaine Drug2 : DB00892 Oxybuprocaine Pharmacological target (-,-) : BE0000177 Sodium channel protein type 10 subunit alpha --------------------------------------------------- Drug1 : DB00807 Proparacaine Drug2 : DB00961 Mepivacaine Pharmacological target (-,-) : BE0000177 Sodium channel protein type 10 subunit alpha --------------------------------------------------- Drug1 : DB00807 Proparacaine Drug2 : DB01002 Levobupivacaine Pharmacological target (-,-) : BE0000177 Sodium channel protein type 10 subunit alpha --------------------------------------------------- Drug1 : DB00807 Proparacaine Drug2 : DB01086 Benzocaine Pharmacological target (-,-) : BE0000177 Sodium channel protein type 10 subunit alpha --------------------------------------------------- Drug1 : DB00807 Proparacaine Drug2 : DB01161 Chloroprocaine Pharmacological target (-,-) : BE0000177 Sodium channel protein type 10 subunit alpha Non-common off-target(s) (drug2) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000411 Neuronal acetylcholine receptor subunit alpha-10 (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) --------------------------------------------------- Drug1 : DB00810 Biperiden Drug2 : DB00942 Cycrimine Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) --------------------------------------------------- Drug1 : DB00810 Biperiden Drug2 : DB00979 Cyclopentolate Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) --------------------------------------------------- Drug1 : DB00810 Biperiden Drug2 : DB00986 Glycopyrrolate Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) --------------------------------------------------- Drug1 : DB00810 Biperiden Drug2 : DB01135 Doxacurium chloride Pharmacological target (-,-) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) Non-common off-target(s) (drug2) : BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00810 Biperiden Drug2 : DB01148 Flavoxate Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) Non-common off-target(s) (drug2) : BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00810 Biperiden Drug2 : DB01199 Tubocurarine Pharmacological target (-,-) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) Non-common off-target(s) (drug2) : BE0000426 Acetylcholinesterase (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) --------------------------------------------------- Drug1 : DB00810 Biperiden Drug2 : DB01226 Mivacurium Pharmacological target (-,-) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) --------------------------------------------------- Drug1 : DB00810 Biperiden Drug2 : DB01336 Metocurine Pharmacological target (-,-) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) Non-common off-target(s) (drug2) : BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00810 Biperiden Drug2 : DB01337 Pancuronium Pharmacological target (-,-) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00810 Biperiden Drug2 : DB01338 Pipecuronium Pharmacological target (-,-) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00810 Biperiden Drug2 : DB01339 Vecuronium Pharmacological target (-,-) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) --------------------------------------------------- Drug1 : DB00810 Biperiden Drug2 : DB04843 Mepenzolate Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) --------------------------------------------------- Drug1 : DB00811 Ribavirin Drug2 : DB01024 Mycophenolic acid Pharmacological target (-,-) : BE0000761 Inosine-5'-monophosphate dehydrogenase 1 Non-common off-target(s) (drug1) : BE0003540 Adenosine kinase (1) BE0000261 Cytosolic purine 5'-nucleotidase (1) BE0000457 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (-1) Non-common off-target(s) (drug2) : BE0000722 Inosine-5'-monophosphate dehydrogenase 2 (-1) --------------------------------------------------- Drug1 : DB00812 Phenylbutazone Drug2 : DB00870 Suprofen Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000117 Prostacyclin synthase (-1) --------------------------------------------------- Drug1 : DB00812 Phenylbutazone Drug2 : DB00936 Salicylic acid Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000117 Prostacyclin synthase (-1) Non-common off-target(s) (drug2) : BE0000126 Aldo-keto reductase family 1 member C1 (-1) --------------------------------------------------- Drug1 : DB00812 Phenylbutazone Drug2 : DB00939 Meclofenamic acid Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000117 Prostacyclin synthase (-1) Non-common off-target(s) (drug2) : BE0000248 Arachidonate 5-lipoxygenase (-1) --------------------------------------------------- Drug1 : DB00812 Phenylbutazone Drug2 : DB00945 Acetylsalicylic acid Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000117 Prostacyclin synthase (-1) Non-common off-target(s) (drug2) : BE0000126 Aldo-keto reductase family 1 member C1 (-1) BE0004907 5'-AMP-activated protein kinase (1) BE0004903 Nuclear factor NF-kappa-B (-1) --------------------------------------------------- Drug1 : DB00812 Phenylbutazone Drug2 : DB00991 Oxaprozin Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000117 Prostacyclin synthase (-1) --------------------------------------------------- Drug1 : DB00812 Phenylbutazone Drug2 : DB01014 Balsalazide Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000117 Prostacyclin synthase (-1) Non-common off-target(s) (drug2) : BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0000248 Arachidonate 5-lipoxygenase (-1) --------------------------------------------------- Drug1 : DB00812 Phenylbutazone Drug2 : DB01283 Lumiracoxib Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000117 Prostacyclin synthase (-1) --------------------------------------------------- Drug1 : DB00812 Phenylbutazone Drug2 : DB01397 Magnesium salicylate Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000117 Prostacyclin synthase (-1) --------------------------------------------------- Drug1 : DB00812 Phenylbutazone Drug2 : DB01398 Salicylate-sodium Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000117 Prostacyclin synthase (-1) --------------------------------------------------- Drug1 : DB00812 Phenylbutazone Drug2 : DB01399 Salsalate Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000117 Prostacyclin synthase (-1) --------------------------------------------------- Drug1 : DB00812 Phenylbutazone Drug2 : DB01600 Tiaprofenic acid Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000117 Prostacyclin synthase (-1) --------------------------------------------------- Drug1 : DB00812 Phenylbutazone Drug2 : DB06725 Lornoxicam Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000117 Prostacyclin synthase (-1) --------------------------------------------------- Drug1 : DB00813 Fentanyl Drug2 : DB00913 Anileridine Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) --------------------------------------------------- Drug1 : DB00813 Fentanyl Drug2 : DB00956 Hydrocodone Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Pharmacological target (+,+) : BE0000420 Delta-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (1) --------------------------------------------------- Drug1 : DB00813 Fentanyl Drug2 : DB01227 Levomethadyl Acetate Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) Non-common off-target(s) (drug2) : BE0003585 Neuronal acetylcholine receptor subunit alpha-3 (-1) --------------------------------------------------- Drug1 : DB00813 Fentanyl Drug2 : DB01433 Methadyl Acetate Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) --------------------------------------------------- Drug1 : DB00813 Fentanyl Drug2 : DB01466 Ethylmorphine Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) --------------------------------------------------- Drug1 : DB00813 Fentanyl Drug2 : DB06204 Tapentadol Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB00814 Meloxicam Drug2 : DB01050 Ibuprofen Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) Non-common off-target(s) (drug2) : BE0001088 Tissue-type plasminogen activator (-1) BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0001195 Cystic fibrosis transmembrane conductance regulator (-1) --------------------------------------------------- Drug1 : DB00814 Meloxicam Drug2 : DB01628 Etoricoxib Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) --------------------------------------------------- Drug1 : DB00814 Meloxicam Drug2 : DB04552 Niflumic Acid Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) Non-common off-target(s) (drug2) : BE0003997 Phospholipase A2 (-1) BE0002376 Chloride channel protein ClC-Ka (1) --------------------------------------------------- Drug1 : DB00814 Meloxicam Drug2 : DB04743 Nimesulide Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) --------------------------------------------------- Drug1 : DB00816 Orciprenaline Drug2 : DB00867 Ritodrine Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor --------------------------------------------------- Drug1 : DB00816 Orciprenaline Drug2 : DB00871 Terbutaline Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor --------------------------------------------------- Drug1 : DB00816 Orciprenaline Drug2 : DB00938 Salmeterol Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor --------------------------------------------------- Drug1 : DB00816 Orciprenaline Drug2 : DB00983 Formoterol Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor --------------------------------------------------- Drug1 : DB00816 Orciprenaline Drug2 : DB01001 Salbutamol Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug2) : BE0000172 Beta-1 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00816 Orciprenaline Drug2 : DB01274 Arformoterol Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor --------------------------------------------------- Drug1 : DB00816 Orciprenaline Drug2 : DB01288 Fenoterol Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug2) : BE0000172 Beta-1 adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00816 Orciprenaline Drug2 : DB01291 Pirbuterol Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug2) : BE0000172 Beta-1 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00816 Orciprenaline Drug2 : DB01366 Procaterol Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor --------------------------------------------------- Drug1 : DB00816 Orciprenaline Drug2 : DB01407 Clenbuterol Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug2) : BE0000172 Beta-1 adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) BE0001094 Beta-nerve growth factor (1) --------------------------------------------------- Drug1 : DB00816 Orciprenaline Drug2 : DB01408 Bambuterol Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor --------------------------------------------------- Drug1 : DB00816 Orciprenaline Drug2 : DB05039 Indacaterol Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor --------------------------------------------------- Drug1 : DB00816 Orciprenaline Drug2 : DB09080 Olodaterol Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor --------------------------------------------------- Drug1 : DB00818 Propofol Drug2 : DB06716 Fospropofol Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0002081 Sodium channel protein type 2 subunit alpha (-1) BE0002083 Sodium channel protein type 4 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00819 Acetazolamide Drug2 : DB00880 Chlorothiazide Pharmacological target (-,-) : BE0000267 Carbonic anhydrase 1 Pharmacological target (-,-) : BE0000322 Carbonic anhydrase 2 Pharmacological target (-,-) : BE0000535 Carbonic anhydrase 4 Non-common off-target(s) (drug1) : BE0003629 Carbonic anhydrase 7 (-1) BE0003634 Carbonic anhydrase 14 (-1) BE0003625 Carbonic anhydrase 3 (-1) BE0000880 Aquaporin-1 (-1) Non-common off-target(s) (drug2) : BE0000419 Solute carrier family 12 member 3 (-1) --------------------------------------------------- Drug1 : DB00819 Acetazolamide Drug2 : DB01144 Diclofenamide Pharmacological target (-,-) : BE0000267 Carbonic anhydrase 1 Pharmacological target (-,-) : BE0000322 Carbonic anhydrase 2 Pharmacological target (-,-) : BE0000535 Carbonic anhydrase 4 Pharmacological target (-,-) : BE0003629 Carbonic anhydrase 7 Non-common off-target(s) (drug1) : BE0003634 Carbonic anhydrase 14 (-1) BE0003625 Carbonic anhydrase 3 (-1) BE0000880 Aquaporin-1 (-1) --------------------------------------------------- Drug1 : DB00820 Tadalafil Drug2 : DB00862 Vardenafil Pharmacological target (-,-) : BE0000182 cGMP-specific 3',5'-cyclic phosphodiesterase Non-common off-target(s) (drug1) : BE0003558 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (-1) --------------------------------------------------- Drug1 : DB00820 Tadalafil Drug2 : DB06237 Avanafil Pharmacological target (-,-) : BE0000182 cGMP-specific 3',5'-cyclic phosphodiesterase Non-common off-target(s) (drug1) : BE0003558 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (-1) --------------------------------------------------- Drug1 : DB00820 Tadalafil Drug2 : DB06267 Udenafil Pharmacological target (-,-) : BE0000182 cGMP-specific 3',5'-cyclic phosphodiesterase Non-common off-target(s) (drug1) : BE0003558 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (-1) --------------------------------------------------- Drug1 : DB00821 Carprofen Drug2 : DB01050 Ibuprofen Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) Non-common off-target(s) (drug2) : BE0001088 Tissue-type plasminogen activator (-1) BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0001195 Cystic fibrosis transmembrane conductance regulator (-1) --------------------------------------------------- Drug1 : DB00821 Carprofen Drug2 : DB01628 Etoricoxib Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) --------------------------------------------------- Drug1 : DB00821 Carprofen Drug2 : DB04552 Niflumic Acid Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) Non-common off-target(s) (drug2) : BE0003997 Phospholipase A2 (-1) BE0002376 Chloride channel protein ClC-Ka (1) --------------------------------------------------- Drug1 : DB00821 Carprofen Drug2 : DB04743 Nimesulide Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) --------------------------------------------------- Drug1 : DB00823 Ethynodiol Drug2 : DB00890 Dienestrol Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug1) : BE0000557 Progesterone receptor (1) --------------------------------------------------- Drug1 : DB00823 Ethynodiol Drug2 : DB00957 Norgestimate Pharmacological target (+,+) : BE0000123 Estrogen receptor Pharmacological target (+,+) : BE0000557 Progesterone receptor --------------------------------------------------- Drug1 : DB00823 Ethynodiol Drug2 : DB00977 Ethinyl Estradiol Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug1) : BE0000557 Progesterone receptor (1) Non-common off-target(s) (drug2) : BE0000956 Nuclear receptor subfamily 1 group I member 2 (1) --------------------------------------------------- Drug1 : DB00823 Ethynodiol Drug2 : DB01357 Mestranol Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug1) : BE0000557 Progesterone receptor (1) --------------------------------------------------- Drug1 : DB00823 Ethynodiol Drug2 : DB04573 Estriol Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug1) : BE0000557 Progesterone receptor (1) Non-common off-target(s) (drug2) : BE0000792 Estrogen receptor beta (1) --------------------------------------------------- Drug1 : DB00823 Ethynodiol Drug2 : DB04574 Estropipate Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug1) : BE0000557 Progesterone receptor (1) Non-common off-target(s) (drug2) : BE0000792 Estrogen receptor beta (1) --------------------------------------------------- Drug1 : DB00823 Ethynodiol Drug2 : DB04575 Quinestrol Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug1) : BE0000557 Progesterone receptor (1) --------------------------------------------------- Drug1 : DB00823 Ethynodiol Drug2 : DB06713 Norelgestromin Pharmacological target (+,+) : BE0000557 Progesterone receptor Non-common off-target(s) (drug1) : BE0000123 Estrogen receptor (1) --------------------------------------------------- Drug1 : DB00824 Enprofylline Drug2 : DB05266 Ibudilast Pharmacological target (-,-) : BE0000487 cAMP-specific 3',5'-cyclic phosphodiesterase 4B Pharmacological target (-,-) : BE0001133 cAMP-specific 3',5'-cyclic phosphodiesterase 4A Non-common off-target(s) (drug1) : BE0000241 Adenosine receptor A2b (-1) Non-common off-target(s) (drug2) : BE0001287 cAMP-specific 3',5'-cyclic phosphodiesterase 4D (-1) BE0000436 cGMP-inhibited 3',5'-cyclic phosphodiesterase A (-1) BE0002353 cAMP-specific 3',5'-cyclic phosphodiesterase 4C (-1) --------------------------------------------------- Drug1 : DB00829 Diazepam Drug2 : DB00842 Oxazepam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Pharmacological target (+,+) : BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Pharmacological target (+,+) : BE0003596 Gamma-aminobutyric acid receptor subunit pi Pharmacological target (+,+) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Pharmacological target (+,+) : BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 Pharmacological target (+,+) : BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 Pharmacological target (+,+) : BE0003597 Gamma-aminobutyric acid receptor subunit theta Non-common off-target(s) (drug1) : BE0000736 Translocator protein (1) Non-common off-target(s) (drug2) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB00829 Diazepam Drug2 : DB00897 Triazolam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Pharmacological target (+,+) : BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Pharmacological target (+,+) : BE0003596 Gamma-aminobutyric acid receptor subunit pi Pharmacological target (+,+) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Pharmacological target (+,+) : BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 Pharmacological target (+,+) : BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 Pharmacological target (+,+) : BE0003597 Gamma-aminobutyric acid receptor subunit theta Non-common off-target(s) (drug1) : BE0000736 Translocator protein (1) Non-common off-target(s) (drug2) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB00829 Diazepam Drug2 : DB01215 Estazolam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Pharmacological target (+,+) : BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Pharmacological target (+,+) : BE0003596 Gamma-aminobutyric acid receptor subunit pi Pharmacological target (+,+) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Pharmacological target (+,+) : BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 Pharmacological target (+,+) : BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 Non-common off-target(s) (drug1) : BE0000736 Translocator protein (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00829 Diazepam Drug2 : DB01558 Bromazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Pharmacological target (+,+) : BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Pharmacological target (+,+) : BE0003596 Gamma-aminobutyric acid receptor subunit pi Pharmacological target (+,+) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Pharmacological target (+,+) : BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 Pharmacological target (+,+) : BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 Pharmacological target (+,+) : BE0003597 Gamma-aminobutyric acid receptor subunit theta Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0000736 Translocator protein (1) Non-common off-target(s) (drug2) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB00829 Diazepam Drug2 : DB01559 Clotiazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Pharmacological target (+,+) : BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Pharmacological target (+,+) : BE0003596 Gamma-aminobutyric acid receptor subunit pi Pharmacological target (+,+) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Pharmacological target (+,+) : BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 Pharmacological target (+,+) : BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0000736 Translocator protein (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00829 Diazepam Drug2 : DB01567 Fludiazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Pharmacological target (+,+) : BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Pharmacological target (+,+) : BE0003596 Gamma-aminobutyric acid receptor subunit pi Pharmacological target (+,+) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Pharmacological target (+,+) : BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 Pharmacological target (+,+) : BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0000736 Translocator protein (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00829 Diazepam Drug2 : DB01588 Prazepam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Pharmacological target (+,+) : BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Pharmacological target (+,+) : BE0003596 Gamma-aminobutyric acid receptor subunit pi Pharmacological target (+,+) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Pharmacological target (+,+) : BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 Pharmacological target (+,+) : BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 Non-common off-target(s) (drug1) : BE0000736 Translocator protein (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00829 Diazepam Drug2 : DB01589 Quazepam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Pharmacological target (+,+) : BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Pharmacological target (+,+) : BE0003596 Gamma-aminobutyric acid receptor subunit pi Pharmacological target (+,+) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Pharmacological target (+,+) : BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 Pharmacological target (+,+) : BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 Non-common off-target(s) (drug1) : BE0000736 Translocator protein (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00829 Diazepam Drug2 : DB01594 Cinolazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Pharmacological target (+,+) : BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Pharmacological target (+,+) : BE0003596 Gamma-aminobutyric acid receptor subunit pi Pharmacological target (+,+) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Pharmacological target (+,+) : BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 Pharmacological target (+,+) : BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0000736 Translocator protein (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00829 Diazepam Drug2 : DB01595 Nitrazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Pharmacological target (+,+) : BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Pharmacological target (+,+) : BE0003596 Gamma-aminobutyric acid receptor subunit pi Pharmacological target (+,+) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Pharmacological target (+,+) : BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 Pharmacological target (+,+) : BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 Pharmacological target (+,+) : BE0003597 Gamma-aminobutyric acid receptor subunit theta Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0000736 Translocator protein (1) Non-common off-target(s) (drug2) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB00830 Phenmetrazine Drug2 : DB00907 Cocaine Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000197 Sodium channel protein type 5 subunit alpha (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) BE0000192 Sodium channel protein type 11 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00830 Phenmetrazine Drug2 : DB00934 Maprotiline Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000442 Histamine H1 receptor (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0004864 Alpha-2 adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0004863 Alpha-1 adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00830 Phenmetrazine Drug2 : DB00937 Diethylpropion Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter --------------------------------------------------- Drug1 : DB00830 Phenmetrazine Drug2 : DB01105 Sibutramine Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) --------------------------------------------------- Drug1 : DB00830 Phenmetrazine Drug2 : DB01156 Bupropion Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug2) : BE0003585 Neuronal acetylcholine receptor subunit alpha-3 (-1) --------------------------------------------------- Drug1 : DB00830 Phenmetrazine Drug2 : DB01255 Lisdexamfetamine Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Non-common off-target(s) (drug1) : BE0000486 Sodium-dependent noradrenaline transporter (-1) Non-common off-target(s) (drug2) : BE0000575 Alpha-1B adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00830 Phenmetrazine Drug2 : DB01463 Fencamfamine Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Non-common off-target(s) (drug1) : BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB00830 Phenmetrazine Drug2 : DB01576 Dextroamphetamine Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (1) BE0001044 Trace amine-associated receptor 1 (1) BE0000575 Alpha-1B adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00830 Phenmetrazine Drug2 : DB01579 Phendimetrazine Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00830 Phenmetrazine Drug2 : DB04896 Milnacipran Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0004956 NMDA receptor (-1) --------------------------------------------------- Drug1 : DB00830 Phenmetrazine Drug2 : DB06204 Tapentadol Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000770 Mu-type opioid receptor (1) --------------------------------------------------- Drug1 : DB00830 Phenmetrazine Drug2 : DB06700 Desvenlafaxine Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) --------------------------------------------------- Drug1 : DB00830 Phenmetrazine Drug2 : DB06701 Dexmethylphenidate Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) --------------------------------------------------- Drug1 : DB00830 Phenmetrazine Drug2 : DB08918 Levomilnacipran Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) --------------------------------------------------- Drug1 : DB00831 Trifluoperazine Drug2 : DB00875 Flupentixol Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Pharmacological target (-,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000666 Neuron-specific vesicular protein calcyon (-1) BE0000418 Calmodulin (-1) BE0004350 Protein S100-A4 (-1) Non-common off-target(s) (drug2) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00834 Mifepristone Drug2 : DB01222 Budesonide Pharmacological target (-,-) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug1) : BE0000557 Progesterone receptor (-1) --------------------------------------------------- Drug1 : DB00835 Brompheniramine Drug2 : DB00902 Methdilazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00835 Brompheniramine Drug2 : DB00950 Fexofenadine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00835 Brompheniramine Drug2 : DB00967 Desloratadine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00835 Brompheniramine Drug2 : DB00972 Azelastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00835 Brompheniramine Drug2 : DB00985 Dimenhydrinate Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00835 Brompheniramine Drug2 : DB01071 Mequitazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00835 Brompheniramine Drug2 : DB01075 Diphenhydramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00835 Brompheniramine Drug2 : DB01084 Emedastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00835 Brompheniramine Drug2 : DB01106 Levocabastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) Non-common off-target(s) (drug2) : BE0000464 Neurotensin receptor type 2 (-1) --------------------------------------------------- Drug1 : DB00835 Brompheniramine Drug2 : DB01114 Chlorphenamine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB00835 Brompheniramine Drug2 : DB01146 Diphenylpyraline Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB00835 Brompheniramine Drug2 : DB01176 Cyclizine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) Non-common off-target(s) (drug2) : BE0000951 Estrogen sulfotransferase (-1) --------------------------------------------------- Drug1 : DB00835 Brompheniramine Drug2 : DB01237 Bromodiphenhydramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00835 Brompheniramine Drug2 : DB01246 Alimemazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00835 Brompheniramine Drug2 : DB01615 Aceprometazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00835 Brompheniramine Drug2 : DB01619 Phenindamine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00835 Brompheniramine Drug2 : DB01620 Pheniramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00835 Brompheniramine Drug2 : DB04837 Clofedanol Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00835 Brompheniramine Drug2 : DB04890 Bepotastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00835 Brompheniramine Drug2 : DB06691 Mepyramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00835 Brompheniramine Drug2 : DB08799 Antazoline Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00835 Brompheniramine Drug2 : DB08800 Chloropyramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00835 Brompheniramine Drug2 : DB08802 Isothipendyl Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00835 Brompheniramine Drug2 : DB08936 Chlorcyclizine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00836 Loperamide Drug2 : DB00956 Hydrocodone Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Pharmacological target (+,+) : BE0000420 Delta-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (1) BE0000356 Voltage-dependent P/Q-type calcium channel subunit alpha-1A (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00836 Loperamide Drug2 : DB01439 3-Methylthiofentanyl Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Pharmacological target (+,+) : BE0000632 Kappa-type opioid receptor Pharmacological target (+,+) : BE0000420 Delta-type opioid receptor Non-common off-target(s) (drug1) : BE0000356 Voltage-dependent P/Q-type calcium channel subunit alpha-1A (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00836 Loperamide Drug2 : DB01497 Etorphine Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Pharmacological target (+,+) : BE0000632 Kappa-type opioid receptor Pharmacological target (+,+) : BE0000420 Delta-type opioid receptor Non-common off-target(s) (drug1) : BE0000356 Voltage-dependent P/Q-type calcium channel subunit alpha-1A (-1) BE0000418 Calmodulin (-1) Non-common off-target(s) (drug2) : BE0002378 Nociceptin receptor (1) BE0001063 E3 ubiquitin-protein ligase TRIM13 (1) --------------------------------------------------- Drug1 : DB00836 Loperamide Drug2 : DB01571 3-Methylfentanyl Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Pharmacological target (+,+) : BE0000632 Kappa-type opioid receptor Pharmacological target (+,+) : BE0000420 Delta-type opioid receptor Non-common off-target(s) (drug1) : BE0000356 Voltage-dependent P/Q-type calcium channel subunit alpha-1A (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00836 Loperamide Drug2 : DB06738 Ketobemidone Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Pharmacological target (+,+) : BE0000632 Kappa-type opioid receptor Pharmacological target (+,+) : BE0000420 Delta-type opioid receptor Non-common off-target(s) (drug1) : BE0000356 Voltage-dependent P/Q-type calcium channel subunit alpha-1A (-1) BE0000418 Calmodulin (-1) Non-common off-target(s) (drug2) : BE0004956 NMDA receptor (-1) --------------------------------------------------- Drug1 : DB00837 Progabide Drug2 : DB00962 Zaleplon Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000217 Gamma-aminobutyric acid type B receptor subunit 1 (1) --------------------------------------------------- Drug1 : DB00837 Progabide Drug2 : DB01080 Vigabatrin Pharmacological target (+,+) : BE0000217 Gamma-aminobutyric acid type B receptor subunit 1 Non-common off-target(s) (drug1) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) Non-common off-target(s) (drug2) : BE0000253 4-aminobutyrate aminotransferase, mitochondrial (-1) --------------------------------------------------- Drug1 : DB00837 Progabide Drug2 : DB01107 Methyprylon Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000217 Gamma-aminobutyric acid type B receptor subunit 1 (1) Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) --------------------------------------------------- Drug1 : DB00837 Progabide Drug2 : DB01174 Phenobarbital Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000217 Gamma-aminobutyric acid type B receptor subunit 1 (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0004956 NMDA receptor (-1) --------------------------------------------------- Drug1 : DB00837 Progabide Drug2 : DB01341 Dihydroquinidine barbiturate Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000217 Gamma-aminobutyric acid type B receptor subunit 1 (1) --------------------------------------------------- Drug1 : DB00837 Progabide Drug2 : DB01437 Glutethimide Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000217 Gamma-aminobutyric acid type B receptor subunit 1 (1) Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) --------------------------------------------------- Drug1 : DB00837 Progabide Drug2 : DB08891 Arbaclofen Pharmacological target (+,+) : BE0000217 Gamma-aminobutyric acid type B receptor subunit 1 Non-common off-target(s) (drug1) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) Non-common off-target(s) (drug2) : BE0002340 Gamma-aminobutyric acid type B receptor subunit 2 (1) --------------------------------------------------- Drug1 : DB00837 Progabide Drug2 : DB08892 Arbaclofen Placarbil Pharmacological target (+,+) : BE0000217 Gamma-aminobutyric acid type B receptor subunit 1 Non-common off-target(s) (drug1) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) Non-common off-target(s) (drug2) : BE0002340 Gamma-aminobutyric acid type B receptor subunit 2 (1) --------------------------------------------------- Drug1 : DB00838 Clocortolone Drug2 : DB00846 Flurandrenolide Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00838 Clocortolone Drug2 : DB00860 Prednisolone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00838 Clocortolone Drug2 : DB00873 Loteprednol Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00838 Clocortolone Drug2 : DB00896 Rimexolone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00838 Clocortolone Drug2 : DB00959 Methylprednisolone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00838 Clocortolone Drug2 : DB01013 Clobetasol propionate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00838 Clocortolone Drug2 : DB01047 Fluocinonide Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug2) : BE0004659 Smoothened homolog (1) --------------------------------------------------- Drug1 : DB00838 Clocortolone Drug2 : DB01130 Prednicarbate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00838 Clocortolone Drug2 : DB01234 Dexamethasone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug2) : BE0000005 Nitric oxide synthase, inducible (-1) BE0000422 Annexin A1 (1) BE0000074 Nuclear receptor subfamily 0 group B member 1 (1) --------------------------------------------------- Drug1 : DB00838 Clocortolone Drug2 : DB01260 Desonide Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00838 Clocortolone Drug2 : DB01380 Cortisone acetate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00838 Clocortolone Drug2 : DB01384 Paramethasone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00838 Clocortolone Drug2 : DB01410 Ciclesonide Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00838 Clocortolone Drug2 : DB06781 Difluprednate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00838 Clocortolone Drug2 : DB08906 Fluticasone furoate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00842 Oxazepam Drug2 : DB00897 Triazolam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Pharmacological target (+,+) : BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Pharmacological target (+,+) : BE0003596 Gamma-aminobutyric acid receptor subunit pi Pharmacological target (+,+) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Pharmacological target (+,+) : BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 Pharmacological target (+,+) : BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 Pharmacological target (+,+) : BE0003597 Gamma-aminobutyric acid receptor subunit theta --------------------------------------------------- Drug1 : DB00842 Oxazepam Drug2 : DB01215 Estazolam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Pharmacological target (+,+) : BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Pharmacological target (+,+) : BE0003596 Gamma-aminobutyric acid receptor subunit pi Pharmacological target (+,+) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Pharmacological target (+,+) : BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 Pharmacological target (+,+) : BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 Non-common off-target(s) (drug1) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00842 Oxazepam Drug2 : DB01558 Bromazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Pharmacological target (+,+) : BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Pharmacological target (+,+) : BE0003596 Gamma-aminobutyric acid receptor subunit pi Pharmacological target (+,+) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Pharmacological target (+,+) : BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 Pharmacological target (+,+) : BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 Pharmacological target (+,+) : BE0003597 Gamma-aminobutyric acid receptor subunit theta Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) --------------------------------------------------- Drug1 : DB00842 Oxazepam Drug2 : DB01559 Clotiazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Pharmacological target (+,+) : BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Pharmacological target (+,+) : BE0003596 Gamma-aminobutyric acid receptor subunit pi Pharmacological target (+,+) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Pharmacological target (+,+) : BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 Pharmacological target (+,+) : BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00842 Oxazepam Drug2 : DB01567 Fludiazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Pharmacological target (+,+) : BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Pharmacological target (+,+) : BE0003596 Gamma-aminobutyric acid receptor subunit pi Pharmacological target (+,+) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Pharmacological target (+,+) : BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 Pharmacological target (+,+) : BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00842 Oxazepam Drug2 : DB01588 Prazepam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Pharmacological target (+,+) : BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Pharmacological target (+,+) : BE0003596 Gamma-aminobutyric acid receptor subunit pi Pharmacological target (+,+) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Pharmacological target (+,+) : BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 Pharmacological target (+,+) : BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 Non-common off-target(s) (drug1) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00842 Oxazepam Drug2 : DB01589 Quazepam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Pharmacological target (+,+) : BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Pharmacological target (+,+) : BE0003596 Gamma-aminobutyric acid receptor subunit pi Pharmacological target (+,+) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Pharmacological target (+,+) : BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 Pharmacological target (+,+) : BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 Non-common off-target(s) (drug1) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00842 Oxazepam Drug2 : DB01594 Cinolazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Pharmacological target (+,+) : BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Pharmacological target (+,+) : BE0003596 Gamma-aminobutyric acid receptor subunit pi Pharmacological target (+,+) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Pharmacological target (+,+) : BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 Pharmacological target (+,+) : BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00842 Oxazepam Drug2 : DB01595 Nitrazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Pharmacological target (+,+) : BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Pharmacological target (+,+) : BE0003596 Gamma-aminobutyric acid receptor subunit pi Pharmacological target (+,+) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Pharmacological target (+,+) : BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 Pharmacological target (+,+) : BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 Pharmacological target (+,+) : BE0003597 Gamma-aminobutyric acid receptor subunit theta Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) --------------------------------------------------- Drug1 : DB00843 Donepezil Drug2 : DB00944 Demecarium Pharmacological target (-,-) : BE0000426 Acetylcholinesterase Non-common off-target(s) (drug2) : BE0002180 Cholinesterase (-1) --------------------------------------------------- Drug1 : DB00843 Donepezil Drug2 : DB00981 Physostigmine Pharmacological target (-,-) : BE0000426 Acetylcholinesterase --------------------------------------------------- Drug1 : DB00843 Donepezil Drug2 : DB00989 Rivastigmine Pharmacological target (-,-) : BE0000426 Acetylcholinesterase Non-common off-target(s) (drug2) : BE0002180 Cholinesterase (-1) --------------------------------------------------- Drug1 : DB00843 Donepezil Drug2 : DB01010 Edrophonium Pharmacological target (-,-) : BE0000426 Acetylcholinesterase Non-common off-target(s) (drug2) : BE0002180 Cholinesterase (-1) --------------------------------------------------- Drug1 : DB00843 Donepezil Drug2 : DB01122 Ambenonium Pharmacological target (-,-) : BE0000426 Acetylcholinesterase --------------------------------------------------- Drug1 : DB00843 Donepezil Drug2 : DB01400 Neostigmine Pharmacological target (-,-) : BE0000426 Acetylcholinesterase --------------------------------------------------- Drug1 : DB00843 Donepezil Drug2 : DB08996 Dimetacrine Pharmacological target (-,-) : BE0000426 Acetylcholinesterase --------------------------------------------------- Drug1 : DB00846 Flurandrenolide Drug2 : DB00860 Prednisolone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00846 Flurandrenolide Drug2 : DB00873 Loteprednol Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00846 Flurandrenolide Drug2 : DB00896 Rimexolone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00846 Flurandrenolide Drug2 : DB00959 Methylprednisolone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00846 Flurandrenolide Drug2 : DB01013 Clobetasol propionate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00846 Flurandrenolide Drug2 : DB01047 Fluocinonide Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug2) : BE0004659 Smoothened homolog (1) --------------------------------------------------- Drug1 : DB00846 Flurandrenolide Drug2 : DB01130 Prednicarbate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00846 Flurandrenolide Drug2 : DB01234 Dexamethasone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug2) : BE0000005 Nitric oxide synthase, inducible (-1) BE0000422 Annexin A1 (1) BE0000074 Nuclear receptor subfamily 0 group B member 1 (1) --------------------------------------------------- Drug1 : DB00846 Flurandrenolide Drug2 : DB01260 Desonide Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00846 Flurandrenolide Drug2 : DB01380 Cortisone acetate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00846 Flurandrenolide Drug2 : DB01384 Paramethasone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00846 Flurandrenolide Drug2 : DB01410 Ciclesonide Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00846 Flurandrenolide Drug2 : DB06781 Difluprednate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00846 Flurandrenolide Drug2 : DB08906 Fluticasone furoate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00849 Methylphenobarbital Drug2 : DB01198 Zopiclone Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) Non-common off-target(s) (drug2) : BE0000736 Translocator protein (1) --------------------------------------------------- Drug1 : DB00849 Methylphenobarbital Drug2 : DB01544 Flunitrazepam Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) Non-common off-target(s) (drug2) : BE0000736 Translocator protein (1) --------------------------------------------------- Drug1 : DB00850 Perphenazine Drug2 : DB00875 Flupentixol Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Pharmacological target (-,-) : BE0000020 D(1A) dopamine receptor Non-common off-target(s) (drug1) : BE0000418 Calmodulin (-1) Non-common off-target(s) (drug2) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB00850 Perphenazine Drug2 : DB00933 Mesoridazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000020 D(1A) dopamine receptor (-1) BE0000418 Calmodulin (-1) Non-common off-target(s) (drug2) : BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB00850 Perphenazine Drug2 : DB01038 Carphenazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Pharmacological target (-,-) : BE0000020 D(1A) dopamine receptor Non-common off-target(s) (drug1) : BE0000418 Calmodulin (-1) Non-common off-target(s) (drug2) : BE0000145 D(1B) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00850 Perphenazine Drug2 : DB01063 Acetophenazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Pharmacological target (-,-) : BE0000020 D(1A) dopamine receptor Non-common off-target(s) (drug1) : BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00850 Perphenazine Drug2 : DB01184 Domperidone Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000020 D(1A) dopamine receptor (-1) BE0000418 Calmodulin (-1) Non-common off-target(s) (drug2) : BE0000581 D(3) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00850 Perphenazine Drug2 : DB01233 Metoclopramide Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000020 D(1A) dopamine receptor (-1) BE0000418 Calmodulin (-1) Non-common off-target(s) (drug2) : BE0000092 Muscarinic acetylcholine receptor M1 (1) BE0000311 5-hydroxytryptamine receptor 3A (1) BE0000084 5-hydroxytryptamine receptor 4 (1) --------------------------------------------------- Drug1 : DB00850 Perphenazine Drug2 : DB01425 Alizapride Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000020 D(1A) dopamine receptor (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00850 Perphenazine Drug2 : DB01608 Propericiazine Pharmacological target (-,-) : BE0000020 D(1A) dopamine receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000418 Calmodulin (-1) Non-common off-target(s) (drug2) : BE0000575 Alpha-1B adrenergic receptor (-1) BE0000289 Alpha-2A adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00850 Perphenazine Drug2 : DB01614 Acepromazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Pharmacological target (-,-) : BE0000020 D(1A) dopamine receptor Non-common off-target(s) (drug1) : BE0000418 Calmodulin (-1) Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB00850 Perphenazine Drug2 : DB01618 Molindone Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000020 D(1A) dopamine receptor (-1) BE0000418 Calmodulin (-1) Non-common off-target(s) (drug2) : BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB00850 Perphenazine Drug2 : DB01621 Pipotiazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Pharmacological target (-,-) : BE0000020 D(1A) dopamine receptor Non-common off-target(s) (drug1) : BE0000418 Calmodulin (-1) Non-common off-target(s) (drug2) : BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB00850 Perphenazine Drug2 : DB01623 Thiothixene Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Pharmacological target (-,-) : BE0000020 D(1A) dopamine receptor Non-common off-target(s) (drug1) : BE0000418 Calmodulin (-1) Non-common off-target(s) (drug2) : BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB00850 Perphenazine Drug2 : DB01624 Zuclopenthixol Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Pharmacological target (-,-) : BE0000020 D(1A) dopamine receptor Non-common off-target(s) (drug1) : BE0000418 Calmodulin (-1) Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000145 D(1B) dopamine receptor (-1) BE0000289 Alpha-2A adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00850 Perphenazine Drug2 : DB04842 Fluspirilene Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000020 D(1A) dopamine receptor (-1) BE0000418 Calmodulin (-1) Non-common off-target(s) (drug2) : BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000679 Voltage-dependent calcium channel gamma-1 subunit (-1) --------------------------------------------------- Drug1 : DB00850 Perphenazine Drug2 : DB06288 Amisulpride Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000020 D(1A) dopamine receptor (-1) BE0000418 Calmodulin (-1) Non-common off-target(s) (drug2) : BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000581 D(3) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00850 Perphenazine Drug2 : DB08815 Lurasidone Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000020 D(1A) dopamine receptor (-1) BE0000418 Calmodulin (-1) Non-common off-target(s) (drug2) : BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000342 Alpha-2C adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00850 Perphenazine Drug2 : DB09018 Bromopride Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000020 D(1A) dopamine receptor (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00852 Pseudoephedrine Drug2 : DB00907 Cocaine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000197 Sodium channel protein type 5 subunit alpha (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) BE0000192 Sodium channel protein type 11 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00852 Pseudoephedrine Drug2 : DB01105 Sibutramine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00852 Pseudoephedrine Drug2 : DB01472 4-Methoxyamphetamine Pharmacological target (+,+) : BE0000501 Alpha-1A adrenergic receptor Pharmacological target (+,+) : BE0000289 Alpha-2A adrenergic receptor Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Non-common off-target(s) (drug1) : BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) --------------------------------------------------- Drug1 : DB00854 Levorphanol Drug2 : DB00913 Anileridine Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) --------------------------------------------------- Drug1 : DB00854 Levorphanol Drug2 : DB01227 Levomethadyl Acetate Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) Non-common off-target(s) (drug2) : BE0003585 Neuronal acetylcholine receptor subunit alpha-3 (-1) --------------------------------------------------- Drug1 : DB00854 Levorphanol Drug2 : DB01433 Methadyl Acetate Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) --------------------------------------------------- Drug1 : DB00854 Levorphanol Drug2 : DB01466 Ethylmorphine Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) --------------------------------------------------- Drug1 : DB00854 Levorphanol Drug2 : DB06204 Tapentadol Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB00857 Terbinafine Drug2 : DB01091 Butenafine Pharmacological target (-,-) : BE0000577 Squalene monooxygenase --------------------------------------------------- Drug1 : DB00858 Drostanolone Drug2 : DB00984 Nandrolone phenpropionate Pharmacological target (+,+) : BE0000132 Androgen receptor --------------------------------------------------- Drug1 : DB00858 Drostanolone Drug2 : DB01420 Testosterone Propionate Pharmacological target (+,+) : BE0000132 Androgen receptor --------------------------------------------------- Drug1 : DB00858 Drostanolone Drug2 : DB01481 Delta1-dihydrotestosterone Pharmacological target (+,+) : BE0000132 Androgen receptor --------------------------------------------------- Drug1 : DB00858 Drostanolone Drug2 : DB01541 Boldenone Pharmacological target (+,+) : BE0000132 Androgen receptor --------------------------------------------------- Drug1 : DB00858 Drostanolone Drug2 : DB06710 Methyltestosterone Pharmacological target (+,+) : BE0000132 Androgen receptor --------------------------------------------------- Drug1 : DB00858 Drostanolone Drug2 : DB08804 Nandrolone decanoate Pharmacological target (+,+) : BE0000132 Androgen receptor --------------------------------------------------- Drug1 : DB00860 Prednisolone Drug2 : DB00873 Loteprednol Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00860 Prednisolone Drug2 : DB00896 Rimexolone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00860 Prednisolone Drug2 : DB00959 Methylprednisolone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00860 Prednisolone Drug2 : DB01013 Clobetasol propionate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00860 Prednisolone Drug2 : DB01047 Fluocinonide Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug2) : BE0004659 Smoothened homolog (1) --------------------------------------------------- Drug1 : DB00860 Prednisolone Drug2 : DB01130 Prednicarbate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00860 Prednisolone Drug2 : DB01234 Dexamethasone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug2) : BE0000005 Nitric oxide synthase, inducible (-1) BE0000422 Annexin A1 (1) BE0000074 Nuclear receptor subfamily 0 group B member 1 (1) --------------------------------------------------- Drug1 : DB00860 Prednisolone Drug2 : DB01260 Desonide Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00860 Prednisolone Drug2 : DB01380 Cortisone acetate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00860 Prednisolone Drug2 : DB01384 Paramethasone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00860 Prednisolone Drug2 : DB01410 Ciclesonide Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00860 Prednisolone Drug2 : DB06781 Difluprednate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00860 Prednisolone Drug2 : DB08906 Fluticasone furoate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00861 Diflunisal Drug2 : DB01050 Ibuprofen Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) Non-common off-target(s) (drug2) : BE0001088 Tissue-type plasminogen activator (-1) BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0001195 Cystic fibrosis transmembrane conductance regulator (-1) --------------------------------------------------- Drug1 : DB00861 Diflunisal Drug2 : DB01628 Etoricoxib Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) --------------------------------------------------- Drug1 : DB00861 Diflunisal Drug2 : DB04552 Niflumic Acid Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) Non-common off-target(s) (drug2) : BE0003997 Phospholipase A2 (-1) BE0002376 Chloride channel protein ClC-Ka (1) --------------------------------------------------- Drug1 : DB00861 Diflunisal Drug2 : DB04743 Nimesulide Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) --------------------------------------------------- Drug1 : DB00862 Vardenafil Drug2 : DB06237 Avanafil Pharmacological target (-,-) : BE0000182 cGMP-specific 3',5'-cyclic phosphodiesterase --------------------------------------------------- Drug1 : DB00862 Vardenafil Drug2 : DB06267 Udenafil Pharmacological target (-,-) : BE0000182 cGMP-specific 3',5'-cyclic phosphodiesterase --------------------------------------------------- Drug1 : DB00863 Ranitidine Drug2 : DB00927 Famotidine Pharmacological target (-,-) : BE0000112 Histamine H2 receptor --------------------------------------------------- Drug1 : DB00863 Ranitidine Drug2 : DB00940 Methantheline Pharmacological target (-,-) : BE0000112 Histamine H2 receptor Non-common off-target(s) (drug2) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) --------------------------------------------------- Drug1 : DB00863 Ranitidine Drug2 : DB08805 Metiamide Pharmacological target (-,-) : BE0000112 Histamine H2 receptor --------------------------------------------------- Drug1 : DB00863 Ranitidine Drug2 : DB08806 Roxatidine acetate Pharmacological target (-,-) : BE0000112 Histamine H2 receptor --------------------------------------------------- Drug1 : DB00865 Benzphetamine Drug2 : DB00935 Oxymetazoline Pharmacological target (+,+) : BE0000501 Alpha-1A adrenergic receptor Pharmacological target (+,+) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0000118 Synaptic vesicular amine transporter (1) BE0000647 Sodium-dependent dopamine transporter (-1) Non-common off-target(s) (drug2) : BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00865 Benzphetamine Drug2 : DB00964 Apraclonidine Pharmacological target (+,+) : BE0000501 Alpha-1A adrenergic receptor Pharmacological target (+,+) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0000118 Synaptic vesicular amine transporter (1) BE0000647 Sodium-dependent dopamine transporter (-1) Non-common off-target(s) (drug2) : BE0000572 Alpha-2B adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00865 Benzphetamine Drug2 : DB06694 Xylometazoline Pharmacological target (+,+) : BE0000501 Alpha-1A adrenergic receptor Pharmacological target (+,+) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0000118 Synaptic vesicular amine transporter (1) BE0000647 Sodium-dependent dopamine transporter (-1) Non-common off-target(s) (drug2) : BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00865 Benzphetamine Drug2 : DB06711 Naphazoline Pharmacological target (+,+) : BE0000501 Alpha-1A adrenergic receptor Pharmacological target (+,+) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0000118 Synaptic vesicular amine transporter (1) BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB00866 Alprenolol Drug2 : DB01210 Levobunolol Pharmacological target (-,-) : BE0000172 Beta-1 adrenergic receptor Pharmacological target (-,-) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0000291 5-hydroxytryptamine receptor 1A (-1) --------------------------------------------------- Drug1 : DB00866 Alprenolol Drug2 : DB01214 Metipranolol Pharmacological target (-,-) : BE0000172 Beta-1 adrenergic receptor Pharmacological target (-,-) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0000291 5-hydroxytryptamine receptor 1A (-1) --------------------------------------------------- Drug1 : DB00867 Ritodrine Drug2 : DB00871 Terbutaline Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor --------------------------------------------------- Drug1 : DB00867 Ritodrine Drug2 : DB00938 Salmeterol Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor --------------------------------------------------- Drug1 : DB00867 Ritodrine Drug2 : DB00983 Formoterol Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor --------------------------------------------------- Drug1 : DB00867 Ritodrine Drug2 : DB01001 Salbutamol Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug2) : BE0000172 Beta-1 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00867 Ritodrine Drug2 : DB01274 Arformoterol Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor --------------------------------------------------- Drug1 : DB00867 Ritodrine Drug2 : DB01288 Fenoterol Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug2) : BE0000172 Beta-1 adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00867 Ritodrine Drug2 : DB01291 Pirbuterol Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug2) : BE0000172 Beta-1 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00867 Ritodrine Drug2 : DB01366 Procaterol Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor --------------------------------------------------- Drug1 : DB00867 Ritodrine Drug2 : DB01407 Clenbuterol Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug2) : BE0000172 Beta-1 adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) BE0001094 Beta-nerve growth factor (1) --------------------------------------------------- Drug1 : DB00867 Ritodrine Drug2 : DB01408 Bambuterol Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor --------------------------------------------------- Drug1 : DB00867 Ritodrine Drug2 : DB05039 Indacaterol Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor --------------------------------------------------- Drug1 : DB00867 Ritodrine Drug2 : DB09080 Olodaterol Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor --------------------------------------------------- Drug1 : DB00870 Suprofen Drug2 : DB00936 Salicylic acid Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug2) : BE0000126 Aldo-keto reductase family 1 member C1 (-1) --------------------------------------------------- Drug1 : DB00870 Suprofen Drug2 : DB00939 Meclofenamic acid Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug2) : BE0000248 Arachidonate 5-lipoxygenase (-1) --------------------------------------------------- Drug1 : DB00870 Suprofen Drug2 : DB00945 Acetylsalicylic acid Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug2) : BE0000126 Aldo-keto reductase family 1 member C1 (-1) BE0004907 5'-AMP-activated protein kinase (1) BE0004903 Nuclear factor NF-kappa-B (-1) --------------------------------------------------- Drug1 : DB00870 Suprofen Drug2 : DB00991 Oxaprozin Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 --------------------------------------------------- Drug1 : DB00870 Suprofen Drug2 : DB01014 Balsalazide Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug2) : BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0000248 Arachidonate 5-lipoxygenase (-1) --------------------------------------------------- Drug1 : DB00870 Suprofen Drug2 : DB01050 Ibuprofen Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) Non-common off-target(s) (drug2) : BE0001088 Tissue-type plasminogen activator (-1) BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0001195 Cystic fibrosis transmembrane conductance regulator (-1) --------------------------------------------------- Drug1 : DB00870 Suprofen Drug2 : DB01283 Lumiracoxib Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 --------------------------------------------------- Drug1 : DB00870 Suprofen Drug2 : DB01397 Magnesium salicylate Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 --------------------------------------------------- Drug1 : DB00870 Suprofen Drug2 : DB01398 Salicylate-sodium Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 --------------------------------------------------- Drug1 : DB00870 Suprofen Drug2 : DB01399 Salsalate Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 --------------------------------------------------- Drug1 : DB00870 Suprofen Drug2 : DB01600 Tiaprofenic acid Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 --------------------------------------------------- Drug1 : DB00870 Suprofen Drug2 : DB01628 Etoricoxib Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) --------------------------------------------------- Drug1 : DB00870 Suprofen Drug2 : DB04552 Niflumic Acid Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) Non-common off-target(s) (drug2) : BE0003997 Phospholipase A2 (-1) BE0002376 Chloride channel protein ClC-Ka (1) --------------------------------------------------- Drug1 : DB00870 Suprofen Drug2 : DB04743 Nimesulide Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) --------------------------------------------------- Drug1 : DB00870 Suprofen Drug2 : DB06725 Lornoxicam Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 --------------------------------------------------- Drug1 : DB00871 Terbutaline Drug2 : DB00938 Salmeterol Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor --------------------------------------------------- Drug1 : DB00871 Terbutaline Drug2 : DB00983 Formoterol Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor --------------------------------------------------- Drug1 : DB00871 Terbutaline Drug2 : DB01001 Salbutamol Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug2) : BE0000172 Beta-1 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00871 Terbutaline Drug2 : DB01274 Arformoterol Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor --------------------------------------------------- Drug1 : DB00871 Terbutaline Drug2 : DB01288 Fenoterol Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug2) : BE0000172 Beta-1 adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00871 Terbutaline Drug2 : DB01291 Pirbuterol Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug2) : BE0000172 Beta-1 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00871 Terbutaline Drug2 : DB01366 Procaterol Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor --------------------------------------------------- Drug1 : DB00871 Terbutaline Drug2 : DB01407 Clenbuterol Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug2) : BE0000172 Beta-1 adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) BE0001094 Beta-nerve growth factor (1) --------------------------------------------------- Drug1 : DB00871 Terbutaline Drug2 : DB01408 Bambuterol Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor --------------------------------------------------- Drug1 : DB00871 Terbutaline Drug2 : DB05039 Indacaterol Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor --------------------------------------------------- Drug1 : DB00871 Terbutaline Drug2 : DB09080 Olodaterol Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor --------------------------------------------------- Drug1 : DB00873 Loteprednol Drug2 : DB00896 Rimexolone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00873 Loteprednol Drug2 : DB00959 Methylprednisolone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00873 Loteprednol Drug2 : DB01013 Clobetasol propionate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00873 Loteprednol Drug2 : DB01047 Fluocinonide Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug2) : BE0004659 Smoothened homolog (1) --------------------------------------------------- Drug1 : DB00873 Loteprednol Drug2 : DB01130 Prednicarbate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00873 Loteprednol Drug2 : DB01234 Dexamethasone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug2) : BE0000005 Nitric oxide synthase, inducible (-1) BE0000422 Annexin A1 (1) BE0000074 Nuclear receptor subfamily 0 group B member 1 (1) --------------------------------------------------- Drug1 : DB00873 Loteprednol Drug2 : DB01260 Desonide Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00873 Loteprednol Drug2 : DB01380 Cortisone acetate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00873 Loteprednol Drug2 : DB01384 Paramethasone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00873 Loteprednol Drug2 : DB01410 Ciclesonide Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00873 Loteprednol Drug2 : DB06781 Difluprednate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00873 Loteprednol Drug2 : DB08906 Fluticasone furoate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00875 Flupentixol Drug2 : DB00933 Mesoridazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00875 Flupentixol Drug2 : DB01038 Carphenazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Pharmacological target (-,-) : BE0000020 D(1A) dopamine receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) Non-common off-target(s) (drug2) : BE0000145 D(1B) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00875 Flupentixol Drug2 : DB01063 Acetophenazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Pharmacological target (-,-) : BE0000020 D(1A) dopamine receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB00875 Flupentixol Drug2 : DB01621 Pipotiazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Pharmacological target (-,-) : BE0000020 D(1A) dopamine receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000291 5-hydroxytryptamine receptor 1A (-1) --------------------------------------------------- Drug1 : DB00875 Flupentixol Drug2 : DB01623 Thiothixene Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Pharmacological target (-,-) : BE0000020 D(1A) dopamine receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00875 Flupentixol Drug2 : DB06144 Sertindole Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000020 D(1A) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) --------------------------------------------------- Drug1 : DB00875 Flupentixol Drug2 : DB08815 Lurasidone Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000020 D(1A) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000342 Alpha-2C adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00876 Eprosartan Drug2 : DB00966 Telmisartan Pharmacological target (-,-) : BE0000062 Type-1 angiotensin II receptor Non-common off-target(s) (drug2) : BE0000215 Peroxisome proliferator-activated receptor gamma (1) --------------------------------------------------- Drug1 : DB00876 Eprosartan Drug2 : DB01029 Irbesartan Pharmacological target (-,-) : BE0000062 Type-1 angiotensin II receptor --------------------------------------------------- Drug1 : DB00876 Eprosartan Drug2 : DB01342 Forasartan Pharmacological target (-,-) : BE0000062 Type-1 angiotensin II receptor --------------------------------------------------- Drug1 : DB00876 Eprosartan Drug2 : DB01347 Saprisartan Pharmacological target (-,-) : BE0000062 Type-1 angiotensin II receptor --------------------------------------------------- Drug1 : DB00876 Eprosartan Drug2 : DB01349 Tasosartan Pharmacological target (-,-) : BE0000062 Type-1 angiotensin II receptor Non-common off-target(s) (drug2) : BE0003426 Type-2 angiotensin II receptor (-1) --------------------------------------------------- Drug1 : DB00876 Eprosartan Drug2 : DB08822 Azilsartan medoxomil Pharmacological target (-,-) : BE0000062 Type-1 angiotensin II receptor --------------------------------------------------- Drug1 : DB00877 Sirolimus Drug2 : DB01590 Everolimus Pharmacological target (-,-) : BE0002386 Serine/threonine-protein kinase mTOR --------------------------------------------------- Drug1 : DB00877 Sirolimus Drug2 : DB06287 Temsirolimus Pharmacological target (-,-) : BE0002386 Serine/threonine-protein kinase mTOR --------------------------------------------------- Drug1 : DB00880 Chlorothiazide Drug2 : DB01031 Ethinamate Pharmacological target (-,-) : BE0000267 Carbonic anhydrase 1 Pharmacological target (-,-) : BE0000322 Carbonic anhydrase 2 Non-common off-target(s) (drug1) : BE0000535 Carbonic anhydrase 4 (-1) BE0000419 Solute carrier family 12 member 3 (-1) --------------------------------------------------- Drug1 : DB00880 Chlorothiazide Drug2 : DB01119 Diazoxide Pharmacological target (-,-) : BE0000267 Carbonic anhydrase 1 Pharmacological target (-,-) : BE0000322 Carbonic anhydrase 2 Non-common off-target(s) (drug1) : BE0000535 Carbonic anhydrase 4 (-1) BE0000419 Solute carrier family 12 member 3 (-1) Non-common off-target(s) (drug2) : BE0000708 ATP-sensitive inward rectifier potassium channel 11 (1) --------------------------------------------------- Drug1 : DB00880 Chlorothiazide Drug2 : DB01144 Diclofenamide Pharmacological target (-,-) : BE0000267 Carbonic anhydrase 1 Pharmacological target (-,-) : BE0000322 Carbonic anhydrase 2 Pharmacological target (-,-) : BE0000535 Carbonic anhydrase 4 Non-common off-target(s) (drug1) : BE0000419 Solute carrier family 12 member 3 (-1) Non-common off-target(s) (drug2) : BE0003629 Carbonic anhydrase 7 (-1) --------------------------------------------------- Drug1 : DB00880 Chlorothiazide Drug2 : DB01325 Quinethazone Pharmacological target (-,-) : BE0000267 Carbonic anhydrase 1 Pharmacological target (-,-) : BE0000322 Carbonic anhydrase 2 Pharmacological target (-,-) : BE0000419 Solute carrier family 12 member 3 Non-common off-target(s) (drug1) : BE0000535 Carbonic anhydrase 4 (-1) Non-common off-target(s) (drug2) : BE0000502 Solute carrier family 12 member 1 (-1) BE0000281 Solute carrier family 12 member 2 (-1) --------------------------------------------------- Drug1 : DB00881 Quinapril Drug2 : DB01180 Rescinnamine Pharmacological target (-,-) : BE0000221 Angiotensin-converting enzyme --------------------------------------------------- Drug1 : DB00881 Quinapril Drug2 : DB01197 Captopril Pharmacological target (-,-) : BE0000221 Angiotensin-converting enzyme Non-common off-target(s) (drug2) : BE0000642 72 kDa type IV collagenase (-1) BE0000058 Matrix metalloproteinase-9 (-1) --------------------------------------------------- Drug1 : DB00881 Quinapril Drug2 : DB01340 Cilazapril Pharmacological target (-,-) : BE0000221 Angiotensin-converting enzyme --------------------------------------------------- Drug1 : DB00881 Quinapril Drug2 : DB01348 Spirapril Pharmacological target (-,-) : BE0000221 Angiotensin-converting enzyme --------------------------------------------------- Drug1 : DB00883 Isosorbide Dinitrate Drug2 : DB01612 Amyl Nitrite Pharmacological target (+,+) : BE0000556 Atrial natriuretic peptide receptor 1 --------------------------------------------------- Drug1 : DB00883 Isosorbide Dinitrate Drug2 : DB01613 Erythrityl Tetranitrate Pharmacological target (+,+) : BE0000556 Atrial natriuretic peptide receptor 1 Non-common off-target(s) (drug2) : BE0000997 Atrial natriuretic peptide receptor 2 (1) --------------------------------------------------- Drug1 : DB00884 Risedronate Drug2 : DB01077 Etidronic acid Pharmacological target (-,-) : BE0004801 Hydroxylapatite Non-common off-target(s) (drug1) : BE0000776 Farnesyl pyrophosphate synthase (-1) Non-common off-target(s) (drug2) : BE0003567 Receptor-type tyrosine-protein phosphatase S (-1) BE0003569 V-type proton ATPase catalytic subunit A (-1) --------------------------------------------------- Drug1 : DB00884 Risedronate Drug2 : DB01133 Tiludronate Pharmacological target (-,-) : BE0004801 Hydroxylapatite Non-common off-target(s) (drug1) : BE0000776 Farnesyl pyrophosphate synthase (-1) Non-common off-target(s) (drug2) : BE0003569 V-type proton ATPase catalytic subunit A (-1) BE0000623 Tyrosine-protein phosphatase non-receptor type 1 (-1) --------------------------------------------------- Drug1 : DB00889 Granisetron Drug2 : DB00904 Ondansetron Pharmacological target (-,-) : BE0000311 5-hydroxytryptamine receptor 3A Non-common off-target(s) (drug2) : BE0000084 5-hydroxytryptamine receptor 4 (1) --------------------------------------------------- Drug1 : DB00889 Granisetron Drug2 : DB00969 Alosetron Pharmacological target (-,-) : BE0000311 5-hydroxytryptamine receptor 3A --------------------------------------------------- Drug1 : DB00889 Granisetron Drug2 : DB01199 Tubocurarine Pharmacological target (-,-) : BE0000311 5-hydroxytryptamine receptor 3A Non-common off-target(s) (drug2) : BE0000426 Acetylcholinesterase (-1) BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) --------------------------------------------------- Drug1 : DB00890 Dienestrol Drug2 : DB00957 Norgestimate Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug2) : BE0000557 Progesterone receptor (1) --------------------------------------------------- Drug1 : DB00890 Dienestrol Drug2 : DB00977 Ethinyl Estradiol Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug2) : BE0000956 Nuclear receptor subfamily 1 group I member 2 (1) --------------------------------------------------- Drug1 : DB00890 Dienestrol Drug2 : DB01357 Mestranol Pharmacological target (+,+) : BE0000123 Estrogen receptor --------------------------------------------------- Drug1 : DB00890 Dienestrol Drug2 : DB04573 Estriol Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug2) : BE0000792 Estrogen receptor beta (1) --------------------------------------------------- Drug1 : DB00890 Dienestrol Drug2 : DB04574 Estropipate Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug2) : BE0000792 Estrogen receptor beta (1) --------------------------------------------------- Drug1 : DB00890 Dienestrol Drug2 : DB04575 Quinestrol Pharmacological target (+,+) : BE0000123 Estrogen receptor --------------------------------------------------- Drug1 : DB00892 Oxybuprocaine Drug2 : DB00961 Mepivacaine Pharmacological target (-,-) : BE0000177 Sodium channel protein type 10 subunit alpha --------------------------------------------------- Drug1 : DB00892 Oxybuprocaine Drug2 : DB01002 Levobupivacaine Pharmacological target (-,-) : BE0000177 Sodium channel protein type 10 subunit alpha --------------------------------------------------- Drug1 : DB00892 Oxybuprocaine Drug2 : DB01086 Benzocaine Pharmacological target (-,-) : BE0000177 Sodium channel protein type 10 subunit alpha --------------------------------------------------- Drug1 : DB00892 Oxybuprocaine Drug2 : DB01161 Chloroprocaine Pharmacological target (-,-) : BE0000177 Sodium channel protein type 10 subunit alpha Non-common off-target(s) (drug2) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000411 Neuronal acetylcholine receptor subunit alpha-10 (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) --------------------------------------------------- Drug1 : DB00894 Testolactone Drug2 : DB00990 Exemestane Pharmacological target (-,-) : BE0002090 Cytochrome P450 19A1 --------------------------------------------------- Drug1 : DB00894 Testolactone Drug2 : DB01006 Letrozole Pharmacological target (-,-) : BE0002090 Cytochrome P450 19A1 --------------------------------------------------- Drug1 : DB00894 Testolactone Drug2 : DB01217 Anastrozole Pharmacological target (-,-) : BE0002090 Cytochrome P450 19A1 --------------------------------------------------- Drug1 : DB00896 Rimexolone Drug2 : DB00959 Methylprednisolone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00896 Rimexolone Drug2 : DB01013 Clobetasol propionate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00896 Rimexolone Drug2 : DB01047 Fluocinonide Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug2) : BE0004659 Smoothened homolog (1) --------------------------------------------------- Drug1 : DB00896 Rimexolone Drug2 : DB01130 Prednicarbate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00896 Rimexolone Drug2 : DB01234 Dexamethasone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug2) : BE0000005 Nitric oxide synthase, inducible (-1) BE0000422 Annexin A1 (1) BE0000074 Nuclear receptor subfamily 0 group B member 1 (1) --------------------------------------------------- Drug1 : DB00896 Rimexolone Drug2 : DB01260 Desonide Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00896 Rimexolone Drug2 : DB01380 Cortisone acetate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00896 Rimexolone Drug2 : DB01384 Paramethasone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00896 Rimexolone Drug2 : DB01410 Ciclesonide Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00896 Rimexolone Drug2 : DB06781 Difluprednate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00896 Rimexolone Drug2 : DB08906 Fluticasone furoate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00897 Triazolam Drug2 : DB01215 Estazolam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Pharmacological target (+,+) : BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Pharmacological target (+,+) : BE0003596 Gamma-aminobutyric acid receptor subunit pi Pharmacological target (+,+) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Pharmacological target (+,+) : BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 Pharmacological target (+,+) : BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 Non-common off-target(s) (drug1) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00897 Triazolam Drug2 : DB01558 Bromazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Pharmacological target (+,+) : BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Pharmacological target (+,+) : BE0003596 Gamma-aminobutyric acid receptor subunit pi Pharmacological target (+,+) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Pharmacological target (+,+) : BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 Pharmacological target (+,+) : BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 Pharmacological target (+,+) : BE0003597 Gamma-aminobutyric acid receptor subunit theta Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) --------------------------------------------------- Drug1 : DB00897 Triazolam Drug2 : DB01559 Clotiazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Pharmacological target (+,+) : BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Pharmacological target (+,+) : BE0003596 Gamma-aminobutyric acid receptor subunit pi Pharmacological target (+,+) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Pharmacological target (+,+) : BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 Pharmacological target (+,+) : BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00897 Triazolam Drug2 : DB01567 Fludiazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Pharmacological target (+,+) : BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Pharmacological target (+,+) : BE0003596 Gamma-aminobutyric acid receptor subunit pi Pharmacological target (+,+) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Pharmacological target (+,+) : BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 Pharmacological target (+,+) : BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00897 Triazolam Drug2 : DB01588 Prazepam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Pharmacological target (+,+) : BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Pharmacological target (+,+) : BE0003596 Gamma-aminobutyric acid receptor subunit pi Pharmacological target (+,+) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Pharmacological target (+,+) : BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 Pharmacological target (+,+) : BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 Non-common off-target(s) (drug1) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00897 Triazolam Drug2 : DB01589 Quazepam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Pharmacological target (+,+) : BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Pharmacological target (+,+) : BE0003596 Gamma-aminobutyric acid receptor subunit pi Pharmacological target (+,+) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Pharmacological target (+,+) : BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 Pharmacological target (+,+) : BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 Non-common off-target(s) (drug1) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00897 Triazolam Drug2 : DB01594 Cinolazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Pharmacological target (+,+) : BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Pharmacological target (+,+) : BE0003596 Gamma-aminobutyric acid receptor subunit pi Pharmacological target (+,+) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Pharmacological target (+,+) : BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 Pharmacological target (+,+) : BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB00897 Triazolam Drug2 : DB01595 Nitrazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Pharmacological target (+,+) : BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Pharmacological target (+,+) : BE0003596 Gamma-aminobutyric acid receptor subunit pi Pharmacological target (+,+) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Pharmacological target (+,+) : BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 Pharmacological target (+,+) : BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 Pharmacological target (+,+) : BE0003597 Gamma-aminobutyric acid receptor subunit theta Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) --------------------------------------------------- Drug1 : DB00899 Remifentanil Drug2 : DB00913 Anileridine Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) --------------------------------------------------- Drug1 : DB00899 Remifentanil Drug2 : DB01227 Levomethadyl Acetate Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) Non-common off-target(s) (drug2) : BE0003585 Neuronal acetylcholine receptor subunit alpha-3 (-1) --------------------------------------------------- Drug1 : DB00899 Remifentanil Drug2 : DB01433 Methadyl Acetate Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) --------------------------------------------------- Drug1 : DB00899 Remifentanil Drug2 : DB01466 Ethylmorphine Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) --------------------------------------------------- Drug1 : DB00899 Remifentanil Drug2 : DB06204 Tapentadol Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB00902 Methdilazine Drug2 : DB00950 Fexofenadine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00902 Methdilazine Drug2 : DB00967 Desloratadine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00902 Methdilazine Drug2 : DB00972 Azelastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00902 Methdilazine Drug2 : DB00985 Dimenhydrinate Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00902 Methdilazine Drug2 : DB01069 Promethazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00902 Methdilazine Drug2 : DB01071 Mequitazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00902 Methdilazine Drug2 : DB01075 Diphenhydramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00902 Methdilazine Drug2 : DB01084 Emedastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00902 Methdilazine Drug2 : DB01106 Levocabastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000464 Neurotensin receptor type 2 (-1) --------------------------------------------------- Drug1 : DB00902 Methdilazine Drug2 : DB01114 Chlorphenamine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB00902 Methdilazine Drug2 : DB01146 Diphenylpyraline Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB00902 Methdilazine Drug2 : DB01176 Cyclizine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000951 Estrogen sulfotransferase (-1) --------------------------------------------------- Drug1 : DB00902 Methdilazine Drug2 : DB01237 Bromodiphenhydramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00902 Methdilazine Drug2 : DB01246 Alimemazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00902 Methdilazine Drug2 : DB01615 Aceprometazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00902 Methdilazine Drug2 : DB01619 Phenindamine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00902 Methdilazine Drug2 : DB01620 Pheniramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00902 Methdilazine Drug2 : DB04837 Clofedanol Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00902 Methdilazine Drug2 : DB04890 Bepotastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00902 Methdilazine Drug2 : DB06691 Mepyramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00902 Methdilazine Drug2 : DB08799 Antazoline Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00902 Methdilazine Drug2 : DB08800 Chloropyramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00902 Methdilazine Drug2 : DB08801 Dimetindene Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00902 Methdilazine Drug2 : DB08802 Isothipendyl Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00902 Methdilazine Drug2 : DB08936 Chlorcyclizine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00903 Ethacrynic acid Drug2 : DB01021 Trichlormethiazide Pharmacological target (-,-) : BE0000502 Solute carrier family 12 member 1 Pharmacological target (-,-) : BE0000732 Sodium/potassium-transporting ATPase subunit alpha-1 Non-common off-target(s) (drug2) : BE0000267 Carbonic anhydrase 1 (-1) BE0000322 Carbonic anhydrase 2 (-1) BE0000535 Carbonic anhydrase 4 (-1) --------------------------------------------------- Drug1 : DB00903 Ethacrynic acid Drug2 : DB01078 Deslanoside Pharmacological target (-,-) : BE0000732 Sodium/potassium-transporting ATPase subunit alpha-1 Non-common off-target(s) (drug1) : BE0000502 Solute carrier family 12 member 1 (-1) --------------------------------------------------- Drug1 : DB00903 Ethacrynic acid Drug2 : DB01092 Ouabain Pharmacological target (-,-) : BE0000732 Sodium/potassium-transporting ATPase subunit alpha-1 Non-common off-target(s) (drug1) : BE0000502 Solute carrier family 12 member 1 (-1) --------------------------------------------------- Drug1 : DB00903 Ethacrynic acid Drug2 : DB01158 Bretylium Pharmacological target (-,-) : BE0000732 Sodium/potassium-transporting ATPase subunit alpha-1 Non-common off-target(s) (drug1) : BE0000502 Solute carrier family 12 member 1 (-1) --------------------------------------------------- Drug1 : DB00903 Ethacrynic acid Drug2 : DB01396 Digitoxin Pharmacological target (-,-) : BE0000732 Sodium/potassium-transporting ATPase subunit alpha-1 Non-common off-target(s) (drug1) : BE0000502 Solute carrier family 12 member 1 (-1) --------------------------------------------------- Drug1 : DB00904 Ondansetron Drug2 : DB00969 Alosetron Pharmacological target (-,-) : BE0000311 5-hydroxytryptamine receptor 3A Non-common off-target(s) (drug1) : BE0000084 5-hydroxytryptamine receptor 4 (1) --------------------------------------------------- Drug1 : DB00904 Ondansetron Drug2 : DB01199 Tubocurarine Pharmacological target (-,-) : BE0000311 5-hydroxytryptamine receptor 3A Non-common off-target(s) (drug1) : BE0000084 5-hydroxytryptamine receptor 4 (1) Non-common off-target(s) (drug2) : BE0000426 Acetylcholinesterase (-1) BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) --------------------------------------------------- Drug1 : DB00905 Bimatoprost Drug2 : DB00917 Dinoprostone Pharmacological target (+,+) : BE0000064 Prostaglandin E2 receptor EP1 subtype Pharmacological target (+,+) : BE0002375 Prostaglandin E2 receptor EP3 subtype Non-common off-target(s) (drug1) : BE0000610 Prostaglandin F2-alpha receptor (1) Non-common off-target(s) (drug2) : BE0000368 Prostaglandin E2 receptor EP2 subtype (1) BE0003522 Prostaglandin E2 receptor EP4 subtype (1) --------------------------------------------------- Drug1 : DB00907 Cocaine Drug2 : DB00937 Diethylpropion Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000197 Sodium channel protein type 5 subunit alpha (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) BE0000192 Sodium channel protein type 11 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00907 Cocaine Drug2 : DB01105 Sibutramine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000197 Sodium channel protein type 5 subunit alpha (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) BE0000192 Sodium channel protein type 11 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00907 Cocaine Drug2 : DB01156 Bupropion Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000197 Sodium channel protein type 5 subunit alpha (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) BE0000192 Sodium channel protein type 11 subunit alpha (-1) Non-common off-target(s) (drug2) : BE0003585 Neuronal acetylcholine receptor subunit alpha-3 (-1) --------------------------------------------------- Drug1 : DB00907 Cocaine Drug2 : DB01576 Dextroamphetamine Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000197 Sodium channel protein type 5 subunit alpha (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) BE0000192 Sodium channel protein type 11 subunit alpha (-1) Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (1) BE0001044 Trace amine-associated receptor 1 (1) BE0000575 Alpha-1B adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00907 Cocaine Drug2 : DB04896 Milnacipran Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000197 Sodium channel protein type 5 subunit alpha (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) BE0000192 Sodium channel protein type 11 subunit alpha (-1) Non-common off-target(s) (drug2) : BE0004956 NMDA receptor (-1) --------------------------------------------------- Drug1 : DB00907 Cocaine Drug2 : DB06700 Desvenlafaxine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000197 Sodium channel protein type 5 subunit alpha (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) BE0000192 Sodium channel protein type 11 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00907 Cocaine Drug2 : DB08918 Levomilnacipran Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000197 Sodium channel protein type 5 subunit alpha (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000177 Sodium channel protein type 10 subunit alpha (-1) BE0000192 Sodium channel protein type 11 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00908 Quinidine Drug2 : DB01056 Tocainide Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000154 Potassium channel subfamily K member 1 (-1) BE0000680 Potassium channel subfamily K member 6 (-1) --------------------------------------------------- Drug1 : DB00908 Quinidine Drug2 : DB01195 Flecainide Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000154 Potassium channel subfamily K member 1 (-1) BE0000680 Potassium channel subfamily K member 6 (-1) Non-common off-target(s) (drug2) : BE0002083 Sodium channel protein type 4 subunit alpha (-1) --------------------------------------------------- Drug1 : DB00908 Quinidine Drug2 : DB01228 Encainide Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000154 Potassium channel subfamily K member 1 (-1) BE0000680 Potassium channel subfamily K member 6 (-1) --------------------------------------------------- Drug1 : DB00908 Quinidine Drug2 : DB01320 Fosphenytoin Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000154 Potassium channel subfamily K member 1 (-1) BE0000680 Potassium channel subfamily K member 6 (-1) --------------------------------------------------- Drug1 : DB00908 Quinidine Drug2 : DB01426 Ajmaline Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000154 Potassium channel subfamily K member 1 (-1) BE0000680 Potassium channel subfamily K member 6 (-1) --------------------------------------------------- Drug1 : DB00908 Quinidine Drug2 : DB01429 Aprindine Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000154 Potassium channel subfamily K member 1 (-1) BE0000680 Potassium channel subfamily K member 6 (-1) Non-common off-target(s) (drug2) : BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00910 Paricalcitol Drug2 : DB01070 Dihydrotachysterol Pharmacological target (+,+) : BE0000779 Vitamin D3 receptor --------------------------------------------------- Drug1 : DB00910 Paricalcitol Drug2 : DB01436 Alfacalcidol Pharmacological target (+,+) : BE0000779 Vitamin D3 receptor --------------------------------------------------- Drug1 : DB00912 Repaglinide Drug2 : DB01124 Tolbutamide Pharmacological target (-,-) : BE0000207 ATP-binding cassette sub-family C member 8 Non-common off-target(s) (drug1) : BE0000215 Peroxisome proliferator-activated receptor gamma (1) Non-common off-target(s) (drug2) : BE0000644 ATP-sensitive inward rectifier potassium channel 1 (-1) --------------------------------------------------- Drug1 : DB00912 Repaglinide Drug2 : DB01251 Gliquidone Pharmacological target (-,-) : BE0000207 ATP-binding cassette sub-family C member 8 Non-common off-target(s) (drug1) : BE0000215 Peroxisome proliferator-activated receptor gamma (1) Non-common off-target(s) (drug2) : BE0002441 ATP-sensitive inward rectifier potassium channel 8 (-1) --------------------------------------------------- Drug1 : DB00913 Anileridine Drug2 : DB00921 Buprenorphine Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug2) : BE0000632 Kappa-type opioid receptor (-1) BE0000420 Delta-type opioid receptor (-1) --------------------------------------------------- Drug1 : DB00913 Anileridine Drug2 : DB00956 Hydrocodone Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug2) : BE0000420 Delta-type opioid receptor (1) --------------------------------------------------- Drug1 : DB00913 Anileridine Drug2 : DB01081 Diphenoxylate Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug2) : BE0000420 Delta-type opioid receptor (1) --------------------------------------------------- Drug1 : DB00913 Anileridine Drug2 : DB01192 Oxymorphone Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug2) : BE0000420 Delta-type opioid receptor (-1) --------------------------------------------------- Drug1 : DB00913 Anileridine Drug2 : DB01209 Dezocine Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug2) : BE0000632 Kappa-type opioid receptor (-1) --------------------------------------------------- Drug1 : DB00913 Anileridine Drug2 : DB01227 Levomethadyl Acetate Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug2) : BE0003585 Neuronal acetylcholine receptor subunit alpha-3 (-1) --------------------------------------------------- Drug1 : DB00913 Anileridine Drug2 : DB01433 Methadyl Acetate Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor --------------------------------------------------- Drug1 : DB00913 Anileridine Drug2 : DB01444 Dimethylthiambutene Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug2) : BE0000420 Delta-type opioid receptor (1) --------------------------------------------------- Drug1 : DB00913 Anileridine Drug2 : DB01452 Heroin Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug2) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) --------------------------------------------------- Drug1 : DB00913 Anileridine Drug2 : DB01466 Ethylmorphine Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor --------------------------------------------------- Drug1 : DB00913 Anileridine Drug2 : DB01535 Carfentanil Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug2) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) --------------------------------------------------- Drug1 : DB00913 Anileridine Drug2 : DB01565 Dihydromorphine Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug2) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) BE0000947 Pro-opiomelanocortin (1) BE0001063 E3 ubiquitin-protein ligase TRIM13 (1) --------------------------------------------------- Drug1 : DB00913 Anileridine Drug2 : DB06204 Tapentadol Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB00915 Amantadine Drug2 : DB01186 Pergolide Pharmacological target (+,+) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) Non-common off-target(s) (drug2) : BE0000533 5-hydroxytryptamine receptor 2C (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000659 5-hydroxytryptamine receptor 1D (1) BE0000797 5-hydroxytryptamine receptor 1B (1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000393 5-hydroxytryptamine receptor 2B (1) BE0000451 5-hydroxytryptamine receptor 2A (1) BE0000020 D(1A) dopamine receptor (1) BE0000145 D(1B) dopamine receptor (1) BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00915 Amantadine Drug2 : DB01200 Bromocriptine Pharmacological target (+,+) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) Non-common off-target(s) (drug2) : BE0000533 5-hydroxytryptamine receptor 2C (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000659 5-hydroxytryptamine receptor 1D (1) BE0000797 5-hydroxytryptamine receptor 1B (1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000393 5-hydroxytryptamine receptor 2B (1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (1) BE0000020 D(1A) dopamine receptor (1) BE0000145 D(1B) dopamine receptor (1) BE0000581 D(3) dopamine receptor (1) BE0000389 D(4) dopamine receptor (-1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00915 Amantadine Drug2 : DB03575 Phencyclidine Pharmacological target (-,-) : BE0000641 Glutamate receptor ionotropic, NMDA 3A Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (1) --------------------------------------------------- Drug1 : DB00921 Buprenorphine Drug2 : DB01209 Dezocine Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Pharmacological target (-,-) : BE0000632 Kappa-type opioid receptor Non-common off-target(s) (drug1) : BE0000420 Delta-type opioid receptor (-1) --------------------------------------------------- Drug1 : DB00921 Buprenorphine Drug2 : DB01227 Levomethadyl Acetate Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (-1) BE0000420 Delta-type opioid receptor (-1) Non-common off-target(s) (drug2) : BE0003585 Neuronal acetylcholine receptor subunit alpha-3 (-1) --------------------------------------------------- Drug1 : DB00921 Buprenorphine Drug2 : DB01433 Methadyl Acetate Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (-1) BE0000420 Delta-type opioid receptor (-1) --------------------------------------------------- Drug1 : DB00921 Buprenorphine Drug2 : DB01466 Ethylmorphine Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (-1) BE0000420 Delta-type opioid receptor (-1) --------------------------------------------------- Drug1 : DB00921 Buprenorphine Drug2 : DB06204 Tapentadol Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (-1) BE0000420 Delta-type opioid receptor (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB00924 Cyclobenzaprine Drug2 : DB00933 Mesoridazine Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00924 Cyclobenzaprine Drug2 : DB01224 Quetiapine Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000145 D(1B) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00924 Cyclobenzaprine Drug2 : DB01238 Aripiprazole Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000659 5-hydroxytryptamine receptor 1D (-1) BE0000797 5-hydroxytryptamine receptor 1B (-1) BE0000476 5-hydroxytryptamine receptor 1E (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00924 Cyclobenzaprine Drug2 : DB04946 Iloperidone Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) BE0000342 Alpha-2C adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00924 Cyclobenzaprine Drug2 : DB06216 Asenapine Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000172 Beta-1 adrenergic receptor (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000694 Beta-2 adrenergic receptor (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000797 5-hydroxytryptamine receptor 1B (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000112 Histamine H2 receptor (-1) BE0004688 5-hydroxytryptamine receptor 5A (-1) --------------------------------------------------- Drug1 : DB00924 Cyclobenzaprine Drug2 : DB08810 Cinitapride Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug2) : BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000084 5-hydroxytryptamine receptor 4 (1) --------------------------------------------------- Drug1 : DB00924 Cyclobenzaprine Drug2 : DB08815 Lurasidone Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000342 Alpha-2C adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00927 Famotidine Drug2 : DB00940 Methantheline Pharmacological target (-,-) : BE0000112 Histamine H2 receptor Non-common off-target(s) (drug2) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) --------------------------------------------------- Drug1 : DB00927 Famotidine Drug2 : DB08805 Metiamide Pharmacological target (-,-) : BE0000112 Histamine H2 receptor --------------------------------------------------- Drug1 : DB00927 Famotidine Drug2 : DB08806 Roxatidine acetate Pharmacological target (-,-) : BE0000112 Histamine H2 receptor --------------------------------------------------- Drug1 : DB00928 Azacitidine Drug2 : DB01262 Decitabine Pharmacological target (-,-) : BE0000892 DNA (cytosine-5)-methyltransferase 1 --------------------------------------------------- Drug1 : DB00933 Mesoridazine Drug2 : DB01063 Acetophenazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000451 5-hydroxytryptamine receptor 2A (-1) Non-common off-target(s) (drug2) : BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00933 Mesoridazine Drug2 : DB01184 Domperidone Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000451 5-hydroxytryptamine receptor 2A (-1) Non-common off-target(s) (drug2) : BE0000581 D(3) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00933 Mesoridazine Drug2 : DB01224 Quetiapine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000145 D(1B) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00933 Mesoridazine Drug2 : DB01233 Metoclopramide Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000451 5-hydroxytryptamine receptor 2A (-1) Non-common off-target(s) (drug2) : BE0000092 Muscarinic acetylcholine receptor M1 (1) BE0000311 5-hydroxytryptamine receptor 3A (1) BE0000084 5-hydroxytryptamine receptor 4 (1) --------------------------------------------------- Drug1 : DB00933 Mesoridazine Drug2 : DB01238 Aripiprazole Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000659 5-hydroxytryptamine receptor 1D (-1) BE0000797 5-hydroxytryptamine receptor 1B (-1) BE0000476 5-hydroxytryptamine receptor 1E (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00933 Mesoridazine Drug2 : DB01425 Alizapride Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB00933 Mesoridazine Drug2 : DB01614 Acepromazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00933 Mesoridazine Drug2 : DB01621 Pipotiazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug2) : BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00933 Mesoridazine Drug2 : DB01623 Thiothixene Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug2) : BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB00933 Mesoridazine Drug2 : DB04946 Iloperidone Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) BE0000342 Alpha-2C adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00933 Mesoridazine Drug2 : DB06144 Sertindole Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug2) : BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) --------------------------------------------------- Drug1 : DB00933 Mesoridazine Drug2 : DB06216 Asenapine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug2) : BE0000172 Beta-1 adrenergic receptor (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000694 Beta-2 adrenergic receptor (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000797 5-hydroxytryptamine receptor 1B (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000112 Histamine H2 receptor (-1) BE0004688 5-hydroxytryptamine receptor 5A (-1) --------------------------------------------------- Drug1 : DB00933 Mesoridazine Drug2 : DB08810 Cinitapride Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000084 5-hydroxytryptamine receptor 4 (1) --------------------------------------------------- Drug1 : DB00933 Mesoridazine Drug2 : DB08815 Lurasidone Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug2) : BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000342 Alpha-2C adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00933 Mesoridazine Drug2 : DB09018 Bromopride Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB00934 Maprotiline Drug2 : DB00937 Diethylpropion Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000442 Histamine H1 receptor (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0004864 Alpha-2 adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0004863 Alpha-1 adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB00934 Maprotiline Drug2 : DB01156 Bupropion Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000442 Histamine H1 receptor (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0004864 Alpha-2 adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0004863 Alpha-1 adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0003585 Neuronal acetylcholine receptor subunit alpha-3 (-1) --------------------------------------------------- Drug1 : DB00934 Maprotiline Drug2 : DB01579 Phendimetrazine Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000442 Histamine H1 receptor (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0004864 Alpha-2 adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0004863 Alpha-1 adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00934 Maprotiline Drug2 : DB04896 Milnacipran Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000442 Histamine H1 receptor (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0004864 Alpha-2 adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0004863 Alpha-1 adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0004956 NMDA receptor (-1) --------------------------------------------------- Drug1 : DB00934 Maprotiline Drug2 : DB06204 Tapentadol Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000442 Histamine H1 receptor (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0004864 Alpha-2 adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0004863 Alpha-1 adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000770 Mu-type opioid receptor (1) --------------------------------------------------- Drug1 : DB00934 Maprotiline Drug2 : DB06700 Desvenlafaxine Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000442 Histamine H1 receptor (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0004864 Alpha-2 adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0004863 Alpha-1 adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) --------------------------------------------------- Drug1 : DB00934 Maprotiline Drug2 : DB06701 Dexmethylphenidate Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000442 Histamine H1 receptor (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0004864 Alpha-2 adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0004863 Alpha-1 adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB00934 Maprotiline Drug2 : DB08918 Levomilnacipran Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000442 Histamine H1 receptor (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0004864 Alpha-2 adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0004863 Alpha-1 adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) --------------------------------------------------- Drug1 : DB00935 Oxymetazoline Drug2 : DB00964 Apraclonidine Pharmacological target (+,+) : BE0000501 Alpha-1A adrenergic receptor Pharmacological target (+,+) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000572 Alpha-2B adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00935 Oxymetazoline Drug2 : DB01018 Guanfacine Pharmacological target (+,+) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00935 Oxymetazoline Drug2 : DB01253 Ergonovine Pharmacological target (+,+) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00935 Oxymetazoline Drug2 : DB04948 Lofexidine Pharmacological target (+,+) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00935 Oxymetazoline Drug2 : DB06706 Isometheptene Pharmacological target (+,+) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (-1) --------------------------------------------------- Drug1 : DB00935 Oxymetazoline Drug2 : DB06707 Levonordefrin Pharmacological target (+,+) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB00935 Oxymetazoline Drug2 : DB06711 Naphazoline Pharmacological target (+,+) : BE0000501 Alpha-1A adrenergic receptor Pharmacological target (+,+) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00936 Salicylic acid Drug2 : DB00939 Meclofenamic acid Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000126 Aldo-keto reductase family 1 member C1 (-1) Non-common off-target(s) (drug2) : BE0000248 Arachidonate 5-lipoxygenase (-1) --------------------------------------------------- Drug1 : DB00936 Salicylic acid Drug2 : DB00991 Oxaprozin Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000126 Aldo-keto reductase family 1 member C1 (-1) --------------------------------------------------- Drug1 : DB00936 Salicylic acid Drug2 : DB01014 Balsalazide Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000126 Aldo-keto reductase family 1 member C1 (-1) Non-common off-target(s) (drug2) : BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0000248 Arachidonate 5-lipoxygenase (-1) --------------------------------------------------- Drug1 : DB00936 Salicylic acid Drug2 : DB01050 Ibuprofen Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) BE0000126 Aldo-keto reductase family 1 member C1 (-1) Non-common off-target(s) (drug2) : BE0001088 Tissue-type plasminogen activator (-1) BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0001195 Cystic fibrosis transmembrane conductance regulator (-1) --------------------------------------------------- Drug1 : DB00936 Salicylic acid Drug2 : DB01283 Lumiracoxib Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000126 Aldo-keto reductase family 1 member C1 (-1) --------------------------------------------------- Drug1 : DB00936 Salicylic acid Drug2 : DB01397 Magnesium salicylate Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000126 Aldo-keto reductase family 1 member C1 (-1) --------------------------------------------------- Drug1 : DB00936 Salicylic acid Drug2 : DB01398 Salicylate-sodium Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000126 Aldo-keto reductase family 1 member C1 (-1) --------------------------------------------------- Drug1 : DB00936 Salicylic acid Drug2 : DB01399 Salsalate Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000126 Aldo-keto reductase family 1 member C1 (-1) --------------------------------------------------- Drug1 : DB00936 Salicylic acid Drug2 : DB01600 Tiaprofenic acid Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000126 Aldo-keto reductase family 1 member C1 (-1) --------------------------------------------------- Drug1 : DB00936 Salicylic acid Drug2 : DB01628 Etoricoxib Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) BE0000126 Aldo-keto reductase family 1 member C1 (-1) --------------------------------------------------- Drug1 : DB00936 Salicylic acid Drug2 : DB04552 Niflumic Acid Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) BE0000126 Aldo-keto reductase family 1 member C1 (-1) Non-common off-target(s) (drug2) : BE0003997 Phospholipase A2 (-1) BE0002376 Chloride channel protein ClC-Ka (1) --------------------------------------------------- Drug1 : DB00936 Salicylic acid Drug2 : DB04743 Nimesulide Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) BE0000126 Aldo-keto reductase family 1 member C1 (-1) --------------------------------------------------- Drug1 : DB00936 Salicylic acid Drug2 : DB06725 Lornoxicam Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000126 Aldo-keto reductase family 1 member C1 (-1) --------------------------------------------------- Drug1 : DB00937 Diethylpropion Drug2 : DB01105 Sibutramine Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) --------------------------------------------------- Drug1 : DB00937 Diethylpropion Drug2 : DB01156 Bupropion Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug2) : BE0003585 Neuronal acetylcholine receptor subunit alpha-3 (-1) --------------------------------------------------- Drug1 : DB00937 Diethylpropion Drug2 : DB01255 Lisdexamfetamine Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Non-common off-target(s) (drug1) : BE0000486 Sodium-dependent noradrenaline transporter (-1) Non-common off-target(s) (drug2) : BE0000575 Alpha-1B adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00937 Diethylpropion Drug2 : DB01463 Fencamfamine Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Non-common off-target(s) (drug1) : BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB00937 Diethylpropion Drug2 : DB01576 Dextroamphetamine Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (1) BE0001044 Trace amine-associated receptor 1 (1) BE0000575 Alpha-1B adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00937 Diethylpropion Drug2 : DB01579 Phendimetrazine Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00937 Diethylpropion Drug2 : DB04896 Milnacipran Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0004956 NMDA receptor (-1) --------------------------------------------------- Drug1 : DB00937 Diethylpropion Drug2 : DB06204 Tapentadol Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000770 Mu-type opioid receptor (1) --------------------------------------------------- Drug1 : DB00937 Diethylpropion Drug2 : DB06700 Desvenlafaxine Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) --------------------------------------------------- Drug1 : DB00937 Diethylpropion Drug2 : DB06701 Dexmethylphenidate Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) --------------------------------------------------- Drug1 : DB00937 Diethylpropion Drug2 : DB08918 Levomilnacipran Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) --------------------------------------------------- Drug1 : DB00938 Salmeterol Drug2 : DB00983 Formoterol Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor --------------------------------------------------- Drug1 : DB00938 Salmeterol Drug2 : DB01001 Salbutamol Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug2) : BE0000172 Beta-1 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00938 Salmeterol Drug2 : DB01274 Arformoterol Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor --------------------------------------------------- Drug1 : DB00938 Salmeterol Drug2 : DB01288 Fenoterol Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug2) : BE0000172 Beta-1 adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00938 Salmeterol Drug2 : DB01291 Pirbuterol Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug2) : BE0000172 Beta-1 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00938 Salmeterol Drug2 : DB01366 Procaterol Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor --------------------------------------------------- Drug1 : DB00938 Salmeterol Drug2 : DB01407 Clenbuterol Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug2) : BE0000172 Beta-1 adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) BE0001094 Beta-nerve growth factor (1) --------------------------------------------------- Drug1 : DB00938 Salmeterol Drug2 : DB01408 Bambuterol Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor --------------------------------------------------- Drug1 : DB00938 Salmeterol Drug2 : DB05039 Indacaterol Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor --------------------------------------------------- Drug1 : DB00938 Salmeterol Drug2 : DB09080 Olodaterol Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor --------------------------------------------------- Drug1 : DB00939 Meclofenamic acid Drug2 : DB00945 Acetylsalicylic acid Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000248 Arachidonate 5-lipoxygenase (-1) Non-common off-target(s) (drug2) : BE0000126 Aldo-keto reductase family 1 member C1 (-1) BE0004907 5'-AMP-activated protein kinase (1) BE0004903 Nuclear factor NF-kappa-B (-1) --------------------------------------------------- Drug1 : DB00939 Meclofenamic acid Drug2 : DB00991 Oxaprozin Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000248 Arachidonate 5-lipoxygenase (-1) --------------------------------------------------- Drug1 : DB00939 Meclofenamic acid Drug2 : DB01014 Balsalazide Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Pharmacological target (-,-) : BE0000248 Arachidonate 5-lipoxygenase Non-common off-target(s) (drug2) : BE0000215 Peroxisome proliferator-activated receptor gamma (1) --------------------------------------------------- Drug1 : DB00939 Meclofenamic acid Drug2 : DB01283 Lumiracoxib Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000248 Arachidonate 5-lipoxygenase (-1) --------------------------------------------------- Drug1 : DB00939 Meclofenamic acid Drug2 : DB01397 Magnesium salicylate Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000248 Arachidonate 5-lipoxygenase (-1) --------------------------------------------------- Drug1 : DB00939 Meclofenamic acid Drug2 : DB01398 Salicylate-sodium Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000248 Arachidonate 5-lipoxygenase (-1) --------------------------------------------------- Drug1 : DB00939 Meclofenamic acid Drug2 : DB01399 Salsalate Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000248 Arachidonate 5-lipoxygenase (-1) --------------------------------------------------- Drug1 : DB00939 Meclofenamic acid Drug2 : DB01600 Tiaprofenic acid Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000248 Arachidonate 5-lipoxygenase (-1) --------------------------------------------------- Drug1 : DB00939 Meclofenamic acid Drug2 : DB06725 Lornoxicam Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000248 Arachidonate 5-lipoxygenase (-1) --------------------------------------------------- Drug1 : DB00940 Methantheline Drug2 : DB08805 Metiamide Pharmacological target (-,-) : BE0000112 Histamine H2 receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) --------------------------------------------------- Drug1 : DB00940 Methantheline Drug2 : DB08806 Roxatidine acetate Pharmacological target (-,-) : BE0000112 Histamine H2 receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) --------------------------------------------------- Drug1 : DB00941 Hexafluronium Drug2 : DB00989 Rivastigmine Pharmacological target (-,-) : BE0002180 Cholinesterase Non-common off-target(s) (drug2) : BE0000426 Acetylcholinesterase (-1) --------------------------------------------------- Drug1 : DB00941 Hexafluronium Drug2 : DB01010 Edrophonium Pharmacological target (-,-) : BE0002180 Cholinesterase Non-common off-target(s) (drug2) : BE0000426 Acetylcholinesterase (-1) --------------------------------------------------- Drug1 : DB00941 Hexafluronium Drug2 : DB01057 Echothiophate Pharmacological target (-,-) : BE0002180 Cholinesterase --------------------------------------------------- Drug1 : DB00942 Cycrimine Drug2 : DB00979 Cyclopentolate Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 --------------------------------------------------- Drug1 : DB00942 Cycrimine Drug2 : DB00986 Glycopyrrolate Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) --------------------------------------------------- Drug1 : DB00942 Cycrimine Drug2 : DB01148 Flavoxate Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug2) : BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00942 Cycrimine Drug2 : DB04843 Mepenzolate Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) --------------------------------------------------- Drug1 : DB00944 Demecarium Drug2 : DB00981 Physostigmine Pharmacological target (-,-) : BE0000426 Acetylcholinesterase Non-common off-target(s) (drug1) : BE0002180 Cholinesterase (-1) --------------------------------------------------- Drug1 : DB00944 Demecarium Drug2 : DB01122 Ambenonium Pharmacological target (-,-) : BE0000426 Acetylcholinesterase Non-common off-target(s) (drug1) : BE0002180 Cholinesterase (-1) --------------------------------------------------- Drug1 : DB00944 Demecarium Drug2 : DB01400 Neostigmine Pharmacological target (-,-) : BE0000426 Acetylcholinesterase Non-common off-target(s) (drug1) : BE0002180 Cholinesterase (-1) --------------------------------------------------- Drug1 : DB00944 Demecarium Drug2 : DB08996 Dimetacrine Pharmacological target (-,-) : BE0000426 Acetylcholinesterase Non-common off-target(s) (drug1) : BE0002180 Cholinesterase (-1) --------------------------------------------------- Drug1 : DB00945 Acetylsalicylic acid Drug2 : DB00991 Oxaprozin Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000126 Aldo-keto reductase family 1 member C1 (-1) BE0004907 5'-AMP-activated protein kinase (1) BE0004903 Nuclear factor NF-kappa-B (-1) --------------------------------------------------- Drug1 : DB00945 Acetylsalicylic acid Drug2 : DB01014 Balsalazide Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000126 Aldo-keto reductase family 1 member C1 (-1) BE0004907 5'-AMP-activated protein kinase (1) BE0004903 Nuclear factor NF-kappa-B (-1) Non-common off-target(s) (drug2) : BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0000248 Arachidonate 5-lipoxygenase (-1) --------------------------------------------------- Drug1 : DB00945 Acetylsalicylic acid Drug2 : DB01050 Ibuprofen Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) BE0000126 Aldo-keto reductase family 1 member C1 (-1) BE0004907 5'-AMP-activated protein kinase (1) BE0004903 Nuclear factor NF-kappa-B (-1) Non-common off-target(s) (drug2) : BE0001088 Tissue-type plasminogen activator (-1) BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0001195 Cystic fibrosis transmembrane conductance regulator (-1) --------------------------------------------------- Drug1 : DB00945 Acetylsalicylic acid Drug2 : DB01283 Lumiracoxib Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000126 Aldo-keto reductase family 1 member C1 (-1) BE0004907 5'-AMP-activated protein kinase (1) BE0004903 Nuclear factor NF-kappa-B (-1) --------------------------------------------------- Drug1 : DB00945 Acetylsalicylic acid Drug2 : DB01397 Magnesium salicylate Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000126 Aldo-keto reductase family 1 member C1 (-1) BE0004907 5'-AMP-activated protein kinase (1) BE0004903 Nuclear factor NF-kappa-B (-1) --------------------------------------------------- Drug1 : DB00945 Acetylsalicylic acid Drug2 : DB01398 Salicylate-sodium Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000126 Aldo-keto reductase family 1 member C1 (-1) BE0004907 5'-AMP-activated protein kinase (1) BE0004903 Nuclear factor NF-kappa-B (-1) --------------------------------------------------- Drug1 : DB00945 Acetylsalicylic acid Drug2 : DB01399 Salsalate Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000126 Aldo-keto reductase family 1 member C1 (-1) BE0004907 5'-AMP-activated protein kinase (1) BE0004903 Nuclear factor NF-kappa-B (-1) --------------------------------------------------- Drug1 : DB00945 Acetylsalicylic acid Drug2 : DB01600 Tiaprofenic acid Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000126 Aldo-keto reductase family 1 member C1 (-1) BE0004907 5'-AMP-activated protein kinase (1) BE0004903 Nuclear factor NF-kappa-B (-1) --------------------------------------------------- Drug1 : DB00945 Acetylsalicylic acid Drug2 : DB01628 Etoricoxib Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) BE0000126 Aldo-keto reductase family 1 member C1 (-1) BE0004907 5'-AMP-activated protein kinase (1) BE0004903 Nuclear factor NF-kappa-B (-1) --------------------------------------------------- Drug1 : DB00945 Acetylsalicylic acid Drug2 : DB04552 Niflumic Acid Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) BE0000126 Aldo-keto reductase family 1 member C1 (-1) BE0004907 5'-AMP-activated protein kinase (1) BE0004903 Nuclear factor NF-kappa-B (-1) Non-common off-target(s) (drug2) : BE0003997 Phospholipase A2 (-1) BE0002376 Chloride channel protein ClC-Ka (1) --------------------------------------------------- Drug1 : DB00945 Acetylsalicylic acid Drug2 : DB04743 Nimesulide Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) BE0000126 Aldo-keto reductase family 1 member C1 (-1) BE0004907 5'-AMP-activated protein kinase (1) BE0004903 Nuclear factor NF-kappa-B (-1) --------------------------------------------------- Drug1 : DB00945 Acetylsalicylic acid Drug2 : DB06725 Lornoxicam Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000126 Aldo-keto reductase family 1 member C1 (-1) BE0004907 5'-AMP-activated protein kinase (1) BE0004903 Nuclear factor NF-kappa-B (-1) --------------------------------------------------- Drug1 : DB00946 Phenprocoumon Drug2 : DB01418 Acenocoumarol Pharmacological target (-,-) : BE0000713 Vitamin K epoxide reductase complex subunit 1 --------------------------------------------------- Drug1 : DB00949 Felbamate Drug2 : DB01043 Memantine Pharmacological target (-,-) : BE0000760 Glutamate receptor ionotropic, NMDA 2A Pharmacological target (-,-) : BE0000417 Glutamate receptor ionotropic, NMDA 2B Pharmacological target (-,-) : BE0000641 Glutamate receptor ionotropic, NMDA 3A Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (1) BE0003438 Alpha-7 nicotinic cholinergic receptor subunit (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) --------------------------------------------------- Drug1 : DB00949 Felbamate Drug2 : DB01520 Tenocyclidine Pharmacological target (-,-) : BE0000760 Glutamate receptor ionotropic, NMDA 2A Pharmacological target (-,-) : BE0000417 Glutamate receptor ionotropic, NMDA 2B Pharmacological target (-,-) : BE0000641 Glutamate receptor ionotropic, NMDA 3A Non-common off-target(s) (drug2) : BE0000396 Glutamate receptor ionotropic, NMDA 2D (-1) BE0000534 Glutamate receptor ionotropic, NMDA 3B (-1) BE0000454 Glutamate receptor ionotropic, NMDA 2C (-1) BE0003438 Alpha-7 nicotinic cholinergic receptor subunit (-1) --------------------------------------------------- Drug1 : DB00950 Fexofenadine Drug2 : DB00967 Desloratadine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00950 Fexofenadine Drug2 : DB00972 Azelastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00950 Fexofenadine Drug2 : DB00985 Dimenhydrinate Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00950 Fexofenadine Drug2 : DB01069 Promethazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00950 Fexofenadine Drug2 : DB01071 Mequitazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00950 Fexofenadine Drug2 : DB01075 Diphenhydramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00950 Fexofenadine Drug2 : DB01084 Emedastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00950 Fexofenadine Drug2 : DB01106 Levocabastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000464 Neurotensin receptor type 2 (-1) --------------------------------------------------- Drug1 : DB00950 Fexofenadine Drug2 : DB01114 Chlorphenamine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB00950 Fexofenadine Drug2 : DB01146 Diphenylpyraline Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB00950 Fexofenadine Drug2 : DB01176 Cyclizine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000951 Estrogen sulfotransferase (-1) --------------------------------------------------- Drug1 : DB00950 Fexofenadine Drug2 : DB01237 Bromodiphenhydramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00950 Fexofenadine Drug2 : DB01246 Alimemazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00950 Fexofenadine Drug2 : DB01615 Aceprometazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00950 Fexofenadine Drug2 : DB01619 Phenindamine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00950 Fexofenadine Drug2 : DB01620 Pheniramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00950 Fexofenadine Drug2 : DB04837 Clofedanol Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00950 Fexofenadine Drug2 : DB04890 Bepotastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00950 Fexofenadine Drug2 : DB06691 Mepyramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00950 Fexofenadine Drug2 : DB08799 Antazoline Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00950 Fexofenadine Drug2 : DB08800 Chloropyramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00950 Fexofenadine Drug2 : DB08801 Dimetindene Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00950 Fexofenadine Drug2 : DB08802 Isothipendyl Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00950 Fexofenadine Drug2 : DB08936 Chlorcyclizine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00952 Naratriptan Drug2 : DB00953 Rizatriptan Pharmacological target (+,+) : BE0000659 5-hydroxytryptamine receptor 1D Pharmacological target (+,+) : BE0000797 5-hydroxytryptamine receptor 1B Pharmacological target (+,+) : BE0000460 5-hydroxytryptamine receptor 1F Non-common off-target(s) (drug1) : BE0000291 5-hydroxytryptamine receptor 1A (1) --------------------------------------------------- Drug1 : DB00952 Naratriptan Drug2 : DB00998 Frovatriptan Pharmacological target (+,+) : BE0000659 5-hydroxytryptamine receptor 1D Pharmacological target (+,+) : BE0000797 5-hydroxytryptamine receptor 1B Non-common off-target(s) (drug1) : BE0000460 5-hydroxytryptamine receptor 1F (1) BE0000291 5-hydroxytryptamine receptor 1A (1) --------------------------------------------------- Drug1 : DB00953 Rizatriptan Drug2 : DB00998 Frovatriptan Pharmacological target (+,+) : BE0000659 5-hydroxytryptamine receptor 1D Pharmacological target (+,+) : BE0000797 5-hydroxytryptamine receptor 1B Non-common off-target(s) (drug1) : BE0000460 5-hydroxytryptamine receptor 1F (1) --------------------------------------------------- Drug1 : DB00956 Hydrocodone Drug2 : DB01209 Dezocine Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000420 Delta-type opioid receptor (1) Non-common off-target(s) (drug2) : BE0000632 Kappa-type opioid receptor (-1) --------------------------------------------------- Drug1 : DB00956 Hydrocodone Drug2 : DB01227 Levomethadyl Acetate Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000420 Delta-type opioid receptor (1) Non-common off-target(s) (drug2) : BE0003585 Neuronal acetylcholine receptor subunit alpha-3 (-1) --------------------------------------------------- Drug1 : DB00956 Hydrocodone Drug2 : DB01433 Methadyl Acetate Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000420 Delta-type opioid receptor (1) --------------------------------------------------- Drug1 : DB00956 Hydrocodone Drug2 : DB01439 3-Methylthiofentanyl Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Pharmacological target (+,+) : BE0000420 Delta-type opioid receptor Non-common off-target(s) (drug2) : BE0000632 Kappa-type opioid receptor (1) --------------------------------------------------- Drug1 : DB00956 Hydrocodone Drug2 : DB01466 Ethylmorphine Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000420 Delta-type opioid receptor (1) --------------------------------------------------- Drug1 : DB00956 Hydrocodone Drug2 : DB01497 Etorphine Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Pharmacological target (+,+) : BE0000420 Delta-type opioid receptor Non-common off-target(s) (drug2) : BE0000632 Kappa-type opioid receptor (1) BE0002378 Nociceptin receptor (1) BE0001063 E3 ubiquitin-protein ligase TRIM13 (1) --------------------------------------------------- Drug1 : DB00956 Hydrocodone Drug2 : DB01535 Carfentanil Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Pharmacological target (+,+) : BE0000420 Delta-type opioid receptor Non-common off-target(s) (drug2) : BE0000632 Kappa-type opioid receptor (1) --------------------------------------------------- Drug1 : DB00956 Hydrocodone Drug2 : DB01571 3-Methylfentanyl Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Pharmacological target (+,+) : BE0000420 Delta-type opioid receptor Non-common off-target(s) (drug2) : BE0000632 Kappa-type opioid receptor (1) --------------------------------------------------- Drug1 : DB00956 Hydrocodone Drug2 : DB06204 Tapentadol Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000420 Delta-type opioid receptor (1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB00956 Hydrocodone Drug2 : DB06738 Ketobemidone Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Pharmacological target (+,+) : BE0000420 Delta-type opioid receptor Non-common off-target(s) (drug2) : BE0000632 Kappa-type opioid receptor (1) BE0004956 NMDA receptor (-1) --------------------------------------------------- Drug1 : DB00957 Norgestimate Drug2 : DB00977 Ethinyl Estradiol Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug1) : BE0000557 Progesterone receptor (1) Non-common off-target(s) (drug2) : BE0000956 Nuclear receptor subfamily 1 group I member 2 (1) --------------------------------------------------- Drug1 : DB00957 Norgestimate Drug2 : DB01357 Mestranol Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug1) : BE0000557 Progesterone receptor (1) --------------------------------------------------- Drug1 : DB00957 Norgestimate Drug2 : DB04573 Estriol Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug1) : BE0000557 Progesterone receptor (1) Non-common off-target(s) (drug2) : BE0000792 Estrogen receptor beta (1) --------------------------------------------------- Drug1 : DB00957 Norgestimate Drug2 : DB04574 Estropipate Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug1) : BE0000557 Progesterone receptor (1) Non-common off-target(s) (drug2) : BE0000792 Estrogen receptor beta (1) --------------------------------------------------- Drug1 : DB00957 Norgestimate Drug2 : DB04575 Quinestrol Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug1) : BE0000557 Progesterone receptor (1) --------------------------------------------------- Drug1 : DB00957 Norgestimate Drug2 : DB06713 Norelgestromin Pharmacological target (+,+) : BE0000557 Progesterone receptor Non-common off-target(s) (drug1) : BE0000123 Estrogen receptor (1) --------------------------------------------------- Drug1 : DB00959 Methylprednisolone Drug2 : DB01013 Clobetasol propionate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00959 Methylprednisolone Drug2 : DB01047 Fluocinonide Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug2) : BE0004659 Smoothened homolog (1) --------------------------------------------------- Drug1 : DB00959 Methylprednisolone Drug2 : DB01130 Prednicarbate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00959 Methylprednisolone Drug2 : DB01234 Dexamethasone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug2) : BE0000005 Nitric oxide synthase, inducible (-1) BE0000422 Annexin A1 (1) BE0000074 Nuclear receptor subfamily 0 group B member 1 (1) --------------------------------------------------- Drug1 : DB00959 Methylprednisolone Drug2 : DB01260 Desonide Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00959 Methylprednisolone Drug2 : DB01380 Cortisone acetate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00959 Methylprednisolone Drug2 : DB01384 Paramethasone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00959 Methylprednisolone Drug2 : DB01410 Ciclesonide Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00959 Methylprednisolone Drug2 : DB06781 Difluprednate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00959 Methylprednisolone Drug2 : DB08906 Fluticasone furoate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB00961 Mepivacaine Drug2 : DB01002 Levobupivacaine Pharmacological target (-,-) : BE0000177 Sodium channel protein type 10 subunit alpha --------------------------------------------------- Drug1 : DB00961 Mepivacaine Drug2 : DB01086 Benzocaine Pharmacological target (-,-) : BE0000177 Sodium channel protein type 10 subunit alpha --------------------------------------------------- Drug1 : DB00961 Mepivacaine Drug2 : DB01161 Chloroprocaine Pharmacological target (-,-) : BE0000177 Sodium channel protein type 10 subunit alpha Non-common off-target(s) (drug2) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000411 Neuronal acetylcholine receptor subunit alpha-10 (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) --------------------------------------------------- Drug1 : DB00962 Zaleplon Drug2 : DB01107 Methyprylon Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) --------------------------------------------------- Drug1 : DB00962 Zaleplon Drug2 : DB01174 Phenobarbital Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0004956 NMDA receptor (-1) --------------------------------------------------- Drug1 : DB00962 Zaleplon Drug2 : DB01341 Dihydroquinidine barbiturate Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 --------------------------------------------------- Drug1 : DB00962 Zaleplon Drug2 : DB01437 Glutethimide Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) --------------------------------------------------- Drug1 : DB00963 Bromfenac Drug2 : DB01050 Ibuprofen Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) Non-common off-target(s) (drug2) : BE0001088 Tissue-type plasminogen activator (-1) BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0001195 Cystic fibrosis transmembrane conductance regulator (-1) --------------------------------------------------- Drug1 : DB00963 Bromfenac Drug2 : DB01628 Etoricoxib Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) --------------------------------------------------- Drug1 : DB00963 Bromfenac Drug2 : DB04552 Niflumic Acid Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) Non-common off-target(s) (drug2) : BE0003997 Phospholipase A2 (-1) BE0002376 Chloride channel protein ClC-Ka (1) --------------------------------------------------- Drug1 : DB00963 Bromfenac Drug2 : DB04743 Nimesulide Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) --------------------------------------------------- Drug1 : DB00964 Apraclonidine Drug2 : DB01018 Guanfacine Pharmacological target (+,+) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0000501 Alpha-1A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00964 Apraclonidine Drug2 : DB01253 Ergonovine Pharmacological target (+,+) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00964 Apraclonidine Drug2 : DB01579 Phendimetrazine Pharmacological target (+,+) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000575 Alpha-1B adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00964 Apraclonidine Drug2 : DB04948 Lofexidine Pharmacological target (+,+) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0000501 Alpha-1A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00964 Apraclonidine Drug2 : DB06706 Isometheptene Pharmacological target (+,+) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (-1) --------------------------------------------------- Drug1 : DB00964 Apraclonidine Drug2 : DB06707 Levonordefrin Pharmacological target (+,+) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB00964 Apraclonidine Drug2 : DB06711 Naphazoline Pharmacological target (+,+) : BE0000501 Alpha-1A adrenergic receptor Pharmacological target (+,+) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0000572 Alpha-2B adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00966 Telmisartan Drug2 : DB01029 Irbesartan Pharmacological target (-,-) : BE0000062 Type-1 angiotensin II receptor Non-common off-target(s) (drug1) : BE0000215 Peroxisome proliferator-activated receptor gamma (1) --------------------------------------------------- Drug1 : DB00966 Telmisartan Drug2 : DB01132 Pioglitazone Pharmacological target (+,+) : BE0000215 Peroxisome proliferator-activated receptor gamma Non-common off-target(s) (drug1) : BE0000062 Type-1 angiotensin II receptor (-1) --------------------------------------------------- Drug1 : DB00966 Telmisartan Drug2 : DB01342 Forasartan Pharmacological target (-,-) : BE0000062 Type-1 angiotensin II receptor Non-common off-target(s) (drug1) : BE0000215 Peroxisome proliferator-activated receptor gamma (1) --------------------------------------------------- Drug1 : DB00966 Telmisartan Drug2 : DB01347 Saprisartan Pharmacological target (-,-) : BE0000062 Type-1 angiotensin II receptor Non-common off-target(s) (drug1) : BE0000215 Peroxisome proliferator-activated receptor gamma (1) --------------------------------------------------- Drug1 : DB00966 Telmisartan Drug2 : DB01349 Tasosartan Pharmacological target (-,-) : BE0000062 Type-1 angiotensin II receptor Non-common off-target(s) (drug1) : BE0000215 Peroxisome proliferator-activated receptor gamma (1) Non-common off-target(s) (drug2) : BE0003426 Type-2 angiotensin II receptor (-1) --------------------------------------------------- Drug1 : DB00966 Telmisartan Drug2 : DB08822 Azilsartan medoxomil Pharmacological target (-,-) : BE0000062 Type-1 angiotensin II receptor Non-common off-target(s) (drug1) : BE0000215 Peroxisome proliferator-activated receptor gamma (1) --------------------------------------------------- Drug1 : DB00966 Telmisartan Drug2 : DB08915 Aleglitazar Pharmacological target (+,+) : BE0000215 Peroxisome proliferator-activated receptor gamma Non-common off-target(s) (drug1) : BE0000062 Type-1 angiotensin II receptor (-1) Non-common off-target(s) (drug2) : BE0000071 Peroxisome proliferator-activated receptor alpha (1) --------------------------------------------------- Drug1 : DB00967 Desloratadine Drug2 : DB00972 Azelastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00967 Desloratadine Drug2 : DB00985 Dimenhydrinate Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00967 Desloratadine Drug2 : DB01069 Promethazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00967 Desloratadine Drug2 : DB01071 Mequitazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00967 Desloratadine Drug2 : DB01075 Diphenhydramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00967 Desloratadine Drug2 : DB01084 Emedastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00967 Desloratadine Drug2 : DB01106 Levocabastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000464 Neurotensin receptor type 2 (-1) --------------------------------------------------- Drug1 : DB00967 Desloratadine Drug2 : DB01114 Chlorphenamine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB00967 Desloratadine Drug2 : DB01146 Diphenylpyraline Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB00967 Desloratadine Drug2 : DB01176 Cyclizine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000951 Estrogen sulfotransferase (-1) --------------------------------------------------- Drug1 : DB00967 Desloratadine Drug2 : DB01237 Bromodiphenhydramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00967 Desloratadine Drug2 : DB01246 Alimemazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00967 Desloratadine Drug2 : DB01615 Aceprometazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00967 Desloratadine Drug2 : DB01619 Phenindamine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00967 Desloratadine Drug2 : DB01620 Pheniramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00967 Desloratadine Drug2 : DB04837 Clofedanol Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00967 Desloratadine Drug2 : DB04890 Bepotastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00967 Desloratadine Drug2 : DB06691 Mepyramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00967 Desloratadine Drug2 : DB08799 Antazoline Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00967 Desloratadine Drug2 : DB08800 Chloropyramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00967 Desloratadine Drug2 : DB08801 Dimetindene Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00967 Desloratadine Drug2 : DB08802 Isothipendyl Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00967 Desloratadine Drug2 : DB08936 Chlorcyclizine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00969 Alosetron Drug2 : DB01199 Tubocurarine Pharmacological target (-,-) : BE0000311 5-hydroxytryptamine receptor 3A Non-common off-target(s) (drug2) : BE0000426 Acetylcholinesterase (-1) BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) --------------------------------------------------- Drug1 : DB00972 Azelastine Drug2 : DB00985 Dimenhydrinate Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00972 Azelastine Drug2 : DB01069 Promethazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00972 Azelastine Drug2 : DB01071 Mequitazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00972 Azelastine Drug2 : DB01075 Diphenhydramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00972 Azelastine Drug2 : DB01084 Emedastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00972 Azelastine Drug2 : DB01106 Levocabastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000464 Neurotensin receptor type 2 (-1) --------------------------------------------------- Drug1 : DB00972 Azelastine Drug2 : DB01114 Chlorphenamine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB00972 Azelastine Drug2 : DB01146 Diphenylpyraline Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB00972 Azelastine Drug2 : DB01176 Cyclizine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000951 Estrogen sulfotransferase (-1) --------------------------------------------------- Drug1 : DB00972 Azelastine Drug2 : DB01237 Bromodiphenhydramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00972 Azelastine Drug2 : DB01246 Alimemazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00972 Azelastine Drug2 : DB01615 Aceprometazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00972 Azelastine Drug2 : DB01619 Phenindamine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00972 Azelastine Drug2 : DB01620 Pheniramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00972 Azelastine Drug2 : DB04837 Clofedanol Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00972 Azelastine Drug2 : DB04890 Bepotastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00972 Azelastine Drug2 : DB06691 Mepyramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00972 Azelastine Drug2 : DB08799 Antazoline Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00972 Azelastine Drug2 : DB08800 Chloropyramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00972 Azelastine Drug2 : DB08801 Dimetindene Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00972 Azelastine Drug2 : DB08802 Isothipendyl Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00972 Azelastine Drug2 : DB08936 Chlorcyclizine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00973 Ezetimibe Drug2 : DB01094 Hesperetin Pharmacological target (-,-) : BE0000105 Sterol O-acyltransferase 1 Non-common off-target(s) (drug1) : BE0000802 Niemann-Pick C1-like protein 1 (-1) Non-common off-target(s) (drug2) : BE0004608 Sterol O-acyltransferase 2 (-1) BE0000232 Microsomal triglyceride transfer protein large subunit (-1) --------------------------------------------------- Drug1 : DB00977 Ethinyl Estradiol Drug2 : DB01357 Mestranol Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug1) : BE0000956 Nuclear receptor subfamily 1 group I member 2 (1) --------------------------------------------------- Drug1 : DB00977 Ethinyl Estradiol Drug2 : DB04573 Estriol Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug1) : BE0000956 Nuclear receptor subfamily 1 group I member 2 (1) Non-common off-target(s) (drug2) : BE0000792 Estrogen receptor beta (1) --------------------------------------------------- Drug1 : DB00977 Ethinyl Estradiol Drug2 : DB04574 Estropipate Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug1) : BE0000956 Nuclear receptor subfamily 1 group I member 2 (1) Non-common off-target(s) (drug2) : BE0000792 Estrogen receptor beta (1) --------------------------------------------------- Drug1 : DB00977 Ethinyl Estradiol Drug2 : DB04575 Quinestrol Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug1) : BE0000956 Nuclear receptor subfamily 1 group I member 2 (1) --------------------------------------------------- Drug1 : DB00979 Cyclopentolate Drug2 : DB00986 Glycopyrrolate Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) --------------------------------------------------- Drug1 : DB00979 Cyclopentolate Drug2 : DB01148 Flavoxate Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug2) : BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00979 Cyclopentolate Drug2 : DB04843 Mepenzolate Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) --------------------------------------------------- Drug1 : DB00981 Physostigmine Drug2 : DB00989 Rivastigmine Pharmacological target (-,-) : BE0000426 Acetylcholinesterase Non-common off-target(s) (drug2) : BE0002180 Cholinesterase (-1) --------------------------------------------------- Drug1 : DB00981 Physostigmine Drug2 : DB01010 Edrophonium Pharmacological target (-,-) : BE0000426 Acetylcholinesterase Non-common off-target(s) (drug2) : BE0002180 Cholinesterase (-1) --------------------------------------------------- Drug1 : DB00981 Physostigmine Drug2 : DB01122 Ambenonium Pharmacological target (-,-) : BE0000426 Acetylcholinesterase --------------------------------------------------- Drug1 : DB00981 Physostigmine Drug2 : DB01400 Neostigmine Pharmacological target (-,-) : BE0000426 Acetylcholinesterase --------------------------------------------------- Drug1 : DB00981 Physostigmine Drug2 : DB08996 Dimetacrine Pharmacological target (-,-) : BE0000426 Acetylcholinesterase --------------------------------------------------- Drug1 : DB00983 Formoterol Drug2 : DB01001 Salbutamol Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug2) : BE0000172 Beta-1 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00983 Formoterol Drug2 : DB01274 Arformoterol Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor --------------------------------------------------- Drug1 : DB00983 Formoterol Drug2 : DB01288 Fenoterol Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug2) : BE0000172 Beta-1 adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00983 Formoterol Drug2 : DB01291 Pirbuterol Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug2) : BE0000172 Beta-1 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00983 Formoterol Drug2 : DB01366 Procaterol Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor --------------------------------------------------- Drug1 : DB00983 Formoterol Drug2 : DB01407 Clenbuterol Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug2) : BE0000172 Beta-1 adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) BE0001094 Beta-nerve growth factor (1) --------------------------------------------------- Drug1 : DB00983 Formoterol Drug2 : DB01408 Bambuterol Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor --------------------------------------------------- Drug1 : DB00983 Formoterol Drug2 : DB05039 Indacaterol Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor --------------------------------------------------- Drug1 : DB00983 Formoterol Drug2 : DB09080 Olodaterol Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor --------------------------------------------------- Drug1 : DB00984 Nandrolone phenpropionate Drug2 : DB01420 Testosterone Propionate Pharmacological target (+,+) : BE0000132 Androgen receptor --------------------------------------------------- Drug1 : DB00984 Nandrolone phenpropionate Drug2 : DB01481 Delta1-dihydrotestosterone Pharmacological target (+,+) : BE0000132 Androgen receptor --------------------------------------------------- Drug1 : DB00984 Nandrolone phenpropionate Drug2 : DB01541 Boldenone Pharmacological target (+,+) : BE0000132 Androgen receptor --------------------------------------------------- Drug1 : DB00984 Nandrolone phenpropionate Drug2 : DB06710 Methyltestosterone Pharmacological target (+,+) : BE0000132 Androgen receptor --------------------------------------------------- Drug1 : DB00984 Nandrolone phenpropionate Drug2 : DB08804 Nandrolone decanoate Pharmacological target (+,+) : BE0000132 Androgen receptor --------------------------------------------------- Drug1 : DB00985 Dimenhydrinate Drug2 : DB01069 Promethazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB00985 Dimenhydrinate Drug2 : DB01071 Mequitazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00985 Dimenhydrinate Drug2 : DB01075 Diphenhydramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00985 Dimenhydrinate Drug2 : DB01084 Emedastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00985 Dimenhydrinate Drug2 : DB01106 Levocabastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000464 Neurotensin receptor type 2 (-1) --------------------------------------------------- Drug1 : DB00985 Dimenhydrinate Drug2 : DB01114 Chlorphenamine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB00985 Dimenhydrinate Drug2 : DB01146 Diphenylpyraline Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB00985 Dimenhydrinate Drug2 : DB01176 Cyclizine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000951 Estrogen sulfotransferase (-1) --------------------------------------------------- Drug1 : DB00985 Dimenhydrinate Drug2 : DB01237 Bromodiphenhydramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00985 Dimenhydrinate Drug2 : DB01246 Alimemazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00985 Dimenhydrinate Drug2 : DB01615 Aceprometazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00985 Dimenhydrinate Drug2 : DB01619 Phenindamine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00985 Dimenhydrinate Drug2 : DB01620 Pheniramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00985 Dimenhydrinate Drug2 : DB04837 Clofedanol Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00985 Dimenhydrinate Drug2 : DB04890 Bepotastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00985 Dimenhydrinate Drug2 : DB06691 Mepyramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00985 Dimenhydrinate Drug2 : DB08799 Antazoline Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00985 Dimenhydrinate Drug2 : DB08800 Chloropyramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00985 Dimenhydrinate Drug2 : DB08801 Dimetindene Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00985 Dimenhydrinate Drug2 : DB08802 Isothipendyl Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00985 Dimenhydrinate Drug2 : DB08936 Chlorcyclizine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB00986 Glycopyrrolate Drug2 : DB01148 Flavoxate Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) Non-common off-target(s) (drug2) : BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB00988 Dopamine Drug2 : DB01235 L-DOPA Pharmacological target (+,+) : BE0000756 D(2) dopamine receptor Pharmacological target (+,+) : BE0000020 D(1A) dopamine receptor Pharmacological target (+,+) : BE0000145 D(1B) dopamine receptor Pharmacological target (+,+) : BE0000581 D(3) dopamine receptor Pharmacological target (+,+) : BE0000389 D(4) dopamine receptor Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (1) BE0004889 D(1) dopamine receptor (1) --------------------------------------------------- Drug1 : DB00989 Rivastigmine Drug2 : DB01010 Edrophonium Pharmacological target (-,-) : BE0000426 Acetylcholinesterase Pharmacological target (-,-) : BE0002180 Cholinesterase --------------------------------------------------- Drug1 : DB00989 Rivastigmine Drug2 : DB01057 Echothiophate Pharmacological target (-,-) : BE0002180 Cholinesterase Non-common off-target(s) (drug1) : BE0000426 Acetylcholinesterase (-1) --------------------------------------------------- Drug1 : DB00989 Rivastigmine Drug2 : DB01122 Ambenonium Pharmacological target (-,-) : BE0000426 Acetylcholinesterase Non-common off-target(s) (drug1) : BE0002180 Cholinesterase (-1) --------------------------------------------------- Drug1 : DB00989 Rivastigmine Drug2 : DB01400 Neostigmine Pharmacological target (-,-) : BE0000426 Acetylcholinesterase Non-common off-target(s) (drug1) : BE0002180 Cholinesterase (-1) --------------------------------------------------- Drug1 : DB00989 Rivastigmine Drug2 : DB08996 Dimetacrine Pharmacological target (-,-) : BE0000426 Acetylcholinesterase Non-common off-target(s) (drug1) : BE0002180 Cholinesterase (-1) --------------------------------------------------- Drug1 : DB00990 Exemestane Drug2 : DB01006 Letrozole Pharmacological target (-,-) : BE0002090 Cytochrome P450 19A1 --------------------------------------------------- Drug1 : DB00990 Exemestane Drug2 : DB01217 Anastrozole Pharmacological target (-,-) : BE0002090 Cytochrome P450 19A1 --------------------------------------------------- Drug1 : DB00991 Oxaprozin Drug2 : DB01014 Balsalazide Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug2) : BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0000248 Arachidonate 5-lipoxygenase (-1) --------------------------------------------------- Drug1 : DB00991 Oxaprozin Drug2 : DB01050 Ibuprofen Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) Non-common off-target(s) (drug2) : BE0001088 Tissue-type plasminogen activator (-1) BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0001195 Cystic fibrosis transmembrane conductance regulator (-1) --------------------------------------------------- Drug1 : DB00991 Oxaprozin Drug2 : DB01283 Lumiracoxib Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 --------------------------------------------------- Drug1 : DB00991 Oxaprozin Drug2 : DB01397 Magnesium salicylate Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 --------------------------------------------------- Drug1 : DB00991 Oxaprozin Drug2 : DB01398 Salicylate-sodium Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 --------------------------------------------------- Drug1 : DB00991 Oxaprozin Drug2 : DB01399 Salsalate Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 --------------------------------------------------- Drug1 : DB00991 Oxaprozin Drug2 : DB01600 Tiaprofenic acid Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 --------------------------------------------------- Drug1 : DB00991 Oxaprozin Drug2 : DB01628 Etoricoxib Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) --------------------------------------------------- Drug1 : DB00991 Oxaprozin Drug2 : DB04552 Niflumic Acid Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) Non-common off-target(s) (drug2) : BE0003997 Phospholipase A2 (-1) BE0002376 Chloride channel protein ClC-Ka (1) --------------------------------------------------- Drug1 : DB00991 Oxaprozin Drug2 : DB04743 Nimesulide Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) --------------------------------------------------- Drug1 : DB00991 Oxaprozin Drug2 : DB06725 Lornoxicam Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 --------------------------------------------------- Drug1 : DB00993 Azathioprine Drug2 : DB01033 Mercaptopurine Pharmacological target (-,-) : BE0000077 Hypoxanthine-guanine phosphoribosyltransferase Non-common off-target(s) (drug2) : BE0004941 Inosine-5'-monophosphate dehydrogenase (-1) --------------------------------------------------- Drug1 : DB00997 Doxorubicin Drug2 : DB01137 Levofloxacin Pharmacological target (-,-) : BE0000742 DNA topoisomerase 2-alpha --------------------------------------------------- Drug1 : DB00997 Doxorubicin Drug2 : DB01177 Idarubicin Pharmacological target (-,-) : BE0000742 DNA topoisomerase 2-alpha --------------------------------------------------- Drug1 : DB00997 Doxorubicin Drug2 : DB01204 Mitoxantrone Pharmacological target (-,-) : BE0000742 DNA topoisomerase 2-alpha --------------------------------------------------- Drug1 : DB00997 Doxorubicin Drug2 : DB01208 Sparfloxacin Pharmacological target (-,-) : BE0000742 DNA topoisomerase 2-alpha --------------------------------------------------- Drug1 : DB00997 Doxorubicin Drug2 : DB04576 Fleroxacin Pharmacological target (-,-) : BE0000742 DNA topoisomerase 2-alpha --------------------------------------------------- Drug1 : DB00997 Doxorubicin Drug2 : DB09047 Finafloxacin Pharmacological target (-,-) : BE0000742 DNA topoisomerase 2-alpha --------------------------------------------------- Drug1 : DB00999 Hydrochlorothiazide Drug2 : DB01324 Polythiazide Pharmacological target (-,-) : BE0000419 Solute carrier family 12 member 3 Non-common off-target(s) (drug1) : BE0000267 Carbonic anhydrase 1 (-1) BE0000322 Carbonic anhydrase 2 (-1) BE0000535 Carbonic anhydrase 4 (-1) BE0002437 Carbonic anhydrase 9 (-1) BE0001653 Carbonic anhydrase 12 (-1) --------------------------------------------------- Drug1 : DB01001 Salbutamol Drug2 : DB01274 Arformoterol Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0000172 Beta-1 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01001 Salbutamol Drug2 : DB01366 Procaterol Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0000172 Beta-1 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01001 Salbutamol Drug2 : DB01408 Bambuterol Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0000172 Beta-1 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01001 Salbutamol Drug2 : DB05039 Indacaterol Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0000172 Beta-1 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01001 Salbutamol Drug2 : DB09080 Olodaterol Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0000172 Beta-1 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01002 Levobupivacaine Drug2 : DB01086 Benzocaine Pharmacological target (-,-) : BE0000177 Sodium channel protein type 10 subunit alpha --------------------------------------------------- Drug1 : DB01002 Levobupivacaine Drug2 : DB01161 Chloroprocaine Pharmacological target (-,-) : BE0000177 Sodium channel protein type 10 subunit alpha Non-common off-target(s) (drug2) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000411 Neuronal acetylcholine receptor subunit alpha-10 (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) --------------------------------------------------- Drug1 : DB01006 Letrozole Drug2 : DB01217 Anastrozole Pharmacological target (-,-) : BE0002090 Cytochrome P450 19A1 --------------------------------------------------- Drug1 : DB01009 Ketoprofen Drug2 : DB01050 Ibuprofen Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) Non-common off-target(s) (drug2) : BE0001088 Tissue-type plasminogen activator (-1) BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0001195 Cystic fibrosis transmembrane conductance regulator (-1) --------------------------------------------------- Drug1 : DB01009 Ketoprofen Drug2 : DB01628 Etoricoxib Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) --------------------------------------------------- Drug1 : DB01009 Ketoprofen Drug2 : DB04552 Niflumic Acid Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) Non-common off-target(s) (drug2) : BE0003997 Phospholipase A2 (-1) BE0002376 Chloride channel protein ClC-Ka (1) --------------------------------------------------- Drug1 : DB01009 Ketoprofen Drug2 : DB04743 Nimesulide Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) --------------------------------------------------- Drug1 : DB01010 Edrophonium Drug2 : DB01057 Echothiophate Pharmacological target (-,-) : BE0002180 Cholinesterase Non-common off-target(s) (drug1) : BE0000426 Acetylcholinesterase (-1) --------------------------------------------------- Drug1 : DB01010 Edrophonium Drug2 : DB01122 Ambenonium Pharmacological target (-,-) : BE0000426 Acetylcholinesterase Non-common off-target(s) (drug1) : BE0002180 Cholinesterase (-1) --------------------------------------------------- Drug1 : DB01010 Edrophonium Drug2 : DB01400 Neostigmine Pharmacological target (-,-) : BE0000426 Acetylcholinesterase Non-common off-target(s) (drug1) : BE0002180 Cholinesterase (-1) --------------------------------------------------- Drug1 : DB01010 Edrophonium Drug2 : DB08996 Dimetacrine Pharmacological target (-,-) : BE0000426 Acetylcholinesterase Non-common off-target(s) (drug1) : BE0002180 Cholinesterase (-1) --------------------------------------------------- Drug1 : DB01013 Clobetasol propionate Drug2 : DB01047 Fluocinonide Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug2) : BE0004659 Smoothened homolog (1) --------------------------------------------------- Drug1 : DB01013 Clobetasol propionate Drug2 : DB01130 Prednicarbate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB01013 Clobetasol propionate Drug2 : DB01234 Dexamethasone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug2) : BE0000005 Nitric oxide synthase, inducible (-1) BE0000422 Annexin A1 (1) BE0000074 Nuclear receptor subfamily 0 group B member 1 (1) --------------------------------------------------- Drug1 : DB01013 Clobetasol propionate Drug2 : DB01260 Desonide Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB01013 Clobetasol propionate Drug2 : DB01380 Cortisone acetate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB01013 Clobetasol propionate Drug2 : DB01384 Paramethasone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB01013 Clobetasol propionate Drug2 : DB01410 Ciclesonide Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB01013 Clobetasol propionate Drug2 : DB06781 Difluprednate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB01013 Clobetasol propionate Drug2 : DB08906 Fluticasone furoate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB01014 Balsalazide Drug2 : DB01283 Lumiracoxib Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0000248 Arachidonate 5-lipoxygenase (-1) --------------------------------------------------- Drug1 : DB01014 Balsalazide Drug2 : DB01397 Magnesium salicylate Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0000248 Arachidonate 5-lipoxygenase (-1) --------------------------------------------------- Drug1 : DB01014 Balsalazide Drug2 : DB01398 Salicylate-sodium Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0000248 Arachidonate 5-lipoxygenase (-1) --------------------------------------------------- Drug1 : DB01014 Balsalazide Drug2 : DB01399 Salsalate Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0000248 Arachidonate 5-lipoxygenase (-1) --------------------------------------------------- Drug1 : DB01014 Balsalazide Drug2 : DB01600 Tiaprofenic acid Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0000248 Arachidonate 5-lipoxygenase (-1) --------------------------------------------------- Drug1 : DB01014 Balsalazide Drug2 : DB06725 Lornoxicam Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0000248 Arachidonate 5-lipoxygenase (-1) --------------------------------------------------- Drug1 : DB01018 Guanfacine Drug2 : DB04948 Lofexidine Pharmacological target (+,+) : BE0000289 Alpha-2A adrenergic receptor --------------------------------------------------- Drug1 : DB01018 Guanfacine Drug2 : DB06711 Naphazoline Pharmacological target (+,+) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01021 Trichlormethiazide Drug2 : DB01078 Deslanoside Pharmacological target (-,-) : BE0000732 Sodium/potassium-transporting ATPase subunit alpha-1 Non-common off-target(s) (drug1) : BE0000502 Solute carrier family 12 member 1 (-1) BE0000267 Carbonic anhydrase 1 (-1) BE0000322 Carbonic anhydrase 2 (-1) BE0000535 Carbonic anhydrase 4 (-1) --------------------------------------------------- Drug1 : DB01021 Trichlormethiazide Drug2 : DB01092 Ouabain Pharmacological target (-,-) : BE0000732 Sodium/potassium-transporting ATPase subunit alpha-1 Non-common off-target(s) (drug1) : BE0000502 Solute carrier family 12 member 1 (-1) BE0000267 Carbonic anhydrase 1 (-1) BE0000322 Carbonic anhydrase 2 (-1) BE0000535 Carbonic anhydrase 4 (-1) --------------------------------------------------- Drug1 : DB01021 Trichlormethiazide Drug2 : DB01158 Bretylium Pharmacological target (-,-) : BE0000732 Sodium/potassium-transporting ATPase subunit alpha-1 Non-common off-target(s) (drug1) : BE0000502 Solute carrier family 12 member 1 (-1) BE0000267 Carbonic anhydrase 1 (-1) BE0000322 Carbonic anhydrase 2 (-1) BE0000535 Carbonic anhydrase 4 (-1) --------------------------------------------------- Drug1 : DB01021 Trichlormethiazide Drug2 : DB01396 Digitoxin Pharmacological target (-,-) : BE0000732 Sodium/potassium-transporting ATPase subunit alpha-1 Non-common off-target(s) (drug1) : BE0000502 Solute carrier family 12 member 1 (-1) BE0000267 Carbonic anhydrase 1 (-1) BE0000322 Carbonic anhydrase 2 (-1) BE0000535 Carbonic anhydrase 4 (-1) --------------------------------------------------- Drug1 : DB01029 Irbesartan Drug2 : DB01342 Forasartan Pharmacological target (-,-) : BE0000062 Type-1 angiotensin II receptor --------------------------------------------------- Drug1 : DB01029 Irbesartan Drug2 : DB01347 Saprisartan Pharmacological target (-,-) : BE0000062 Type-1 angiotensin II receptor --------------------------------------------------- Drug1 : DB01029 Irbesartan Drug2 : DB01349 Tasosartan Pharmacological target (-,-) : BE0000062 Type-1 angiotensin II receptor Non-common off-target(s) (drug2) : BE0003426 Type-2 angiotensin II receptor (-1) --------------------------------------------------- Drug1 : DB01029 Irbesartan Drug2 : DB08822 Azilsartan medoxomil Pharmacological target (-,-) : BE0000062 Type-1 angiotensin II receptor --------------------------------------------------- Drug1 : DB01030 Topotecan Drug2 : DB05630 Sodium stibogluconate Pharmacological target (-,-) : BE0000971 DNA topoisomerase 1 Non-common off-target(s) (drug1) : BE0000091 DNA topoisomerase I, mitochondrial (-1) --------------------------------------------------- Drug1 : DB01031 Ethinamate Drug2 : DB01119 Diazoxide Pharmacological target (-,-) : BE0000267 Carbonic anhydrase 1 Pharmacological target (-,-) : BE0000322 Carbonic anhydrase 2 Non-common off-target(s) (drug2) : BE0000708 ATP-sensitive inward rectifier potassium channel 11 (1) --------------------------------------------------- Drug1 : DB01031 Ethinamate Drug2 : DB01144 Diclofenamide Pharmacological target (-,-) : BE0000267 Carbonic anhydrase 1 Pharmacological target (-,-) : BE0000322 Carbonic anhydrase 2 Non-common off-target(s) (drug2) : BE0000535 Carbonic anhydrase 4 (-1) BE0003629 Carbonic anhydrase 7 (-1) --------------------------------------------------- Drug1 : DB01036 Tolterodine Drug2 : DB01062 Oxybutynin Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB01036 Tolterodine Drug2 : DB01231 Diphenidol Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB01036 Tolterodine Drug2 : DB08897 Aclidinium Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Pharmacological target (-,-) : BE0000405 Muscarinic acetylcholine receptor M4 Pharmacological target (-,-) : BE0000247 Muscarinic acetylcholine receptor M5 --------------------------------------------------- Drug1 : DB01037 Selegiline Drug2 : DB01367 Rasagiline Pharmacological target (-,-) : BE0002196 Amine oxidase [flavin-containing] B Non-common off-target(s) (drug1) : BE0002198 Amine oxidase [flavin-containing] A (-1) Non-common off-target(s) (drug2) : BE0000246 Apoptosis regulator Bcl-2 (1) --------------------------------------------------- Drug1 : DB01038 Carphenazine Drug2 : DB01063 Acetophenazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Pharmacological target (-,-) : BE0000020 D(1A) dopamine receptor Non-common off-target(s) (drug1) : BE0000145 D(1B) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB01038 Carphenazine Drug2 : DB01614 Acepromazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Pharmacological target (-,-) : BE0000020 D(1A) dopamine receptor Non-common off-target(s) (drug1) : BE0000145 D(1B) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB01038 Carphenazine Drug2 : DB01621 Pipotiazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Pharmacological target (-,-) : BE0000020 D(1A) dopamine receptor Non-common off-target(s) (drug1) : BE0000145 D(1B) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB01038 Carphenazine Drug2 : DB01623 Thiothixene Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Pharmacological target (-,-) : BE0000020 D(1A) dopamine receptor Non-common off-target(s) (drug1) : BE0000145 D(1B) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB01038 Carphenazine Drug2 : DB01624 Zuclopenthixol Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Pharmacological target (-,-) : BE0000020 D(1A) dopamine receptor Pharmacological target (-,-) : BE0000145 D(1B) dopamine receptor Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB01039 Fenofibrate Drug2 : DB01241 Gemfibrozil Pharmacological target (+,+) : BE0000071 Peroxisome proliferator-activated receptor alpha Non-common off-target(s) (drug1) : BE0001020 Metalloproteinase (-1) --------------------------------------------------- Drug1 : DB01039 Fenofibrate Drug2 : DB08915 Aleglitazar Pharmacological target (+,+) : BE0000071 Peroxisome proliferator-activated receptor alpha Non-common off-target(s) (drug1) : BE0001020 Metalloproteinase (-1) Non-common off-target(s) (drug2) : BE0000215 Peroxisome proliferator-activated receptor gamma (1) --------------------------------------------------- Drug1 : DB01047 Fluocinonide Drug2 : DB01130 Prednicarbate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug1) : BE0004659 Smoothened homolog (1) --------------------------------------------------- Drug1 : DB01047 Fluocinonide Drug2 : DB01234 Dexamethasone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug1) : BE0004659 Smoothened homolog (1) Non-common off-target(s) (drug2) : BE0000005 Nitric oxide synthase, inducible (-1) BE0000422 Annexin A1 (1) BE0000074 Nuclear receptor subfamily 0 group B member 1 (1) --------------------------------------------------- Drug1 : DB01047 Fluocinonide Drug2 : DB01260 Desonide Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug1) : BE0004659 Smoothened homolog (1) --------------------------------------------------- Drug1 : DB01047 Fluocinonide Drug2 : DB01380 Cortisone acetate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug1) : BE0004659 Smoothened homolog (1) --------------------------------------------------- Drug1 : DB01047 Fluocinonide Drug2 : DB01384 Paramethasone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug1) : BE0004659 Smoothened homolog (1) --------------------------------------------------- Drug1 : DB01047 Fluocinonide Drug2 : DB01410 Ciclesonide Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug1) : BE0004659 Smoothened homolog (1) --------------------------------------------------- Drug1 : DB01047 Fluocinonide Drug2 : DB06781 Difluprednate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug1) : BE0004659 Smoothened homolog (1) --------------------------------------------------- Drug1 : DB01047 Fluocinonide Drug2 : DB08906 Fluticasone furoate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug1) : BE0004659 Smoothened homolog (1) --------------------------------------------------- Drug1 : DB01050 Ibuprofen Drug2 : DB01283 Lumiracoxib Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0001088 Tissue-type plasminogen activator (-1) BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0001195 Cystic fibrosis transmembrane conductance regulator (-1) Non-common off-target(s) (drug2) : BE0000017 Prostaglandin G/H synthase 1 (-1) --------------------------------------------------- Drug1 : DB01050 Ibuprofen Drug2 : DB01397 Magnesium salicylate Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0001088 Tissue-type plasminogen activator (-1) BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0001195 Cystic fibrosis transmembrane conductance regulator (-1) Non-common off-target(s) (drug2) : BE0000017 Prostaglandin G/H synthase 1 (-1) --------------------------------------------------- Drug1 : DB01050 Ibuprofen Drug2 : DB01398 Salicylate-sodium Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0001088 Tissue-type plasminogen activator (-1) BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0001195 Cystic fibrosis transmembrane conductance regulator (-1) Non-common off-target(s) (drug2) : BE0000017 Prostaglandin G/H synthase 1 (-1) --------------------------------------------------- Drug1 : DB01050 Ibuprofen Drug2 : DB01399 Salsalate Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0001088 Tissue-type plasminogen activator (-1) BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0001195 Cystic fibrosis transmembrane conductance regulator (-1) Non-common off-target(s) (drug2) : BE0000017 Prostaglandin G/H synthase 1 (-1) --------------------------------------------------- Drug1 : DB01050 Ibuprofen Drug2 : DB01600 Tiaprofenic acid Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0001088 Tissue-type plasminogen activator (-1) BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0001195 Cystic fibrosis transmembrane conductance regulator (-1) Non-common off-target(s) (drug2) : BE0000017 Prostaglandin G/H synthase 1 (-1) --------------------------------------------------- Drug1 : DB01050 Ibuprofen Drug2 : DB01628 Etoricoxib Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0001088 Tissue-type plasminogen activator (-1) BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0001195 Cystic fibrosis transmembrane conductance regulator (-1) --------------------------------------------------- Drug1 : DB01050 Ibuprofen Drug2 : DB04552 Niflumic Acid Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0001088 Tissue-type plasminogen activator (-1) BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0001195 Cystic fibrosis transmembrane conductance regulator (-1) Non-common off-target(s) (drug2) : BE0003997 Phospholipase A2 (-1) BE0002376 Chloride channel protein ClC-Ka (1) --------------------------------------------------- Drug1 : DB01050 Ibuprofen Drug2 : DB04743 Nimesulide Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0001088 Tissue-type plasminogen activator (-1) BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0001195 Cystic fibrosis transmembrane conductance regulator (-1) --------------------------------------------------- Drug1 : DB01050 Ibuprofen Drug2 : DB06725 Lornoxicam Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0001088 Tissue-type plasminogen activator (-1) BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0001195 Cystic fibrosis transmembrane conductance regulator (-1) Non-common off-target(s) (drug2) : BE0000017 Prostaglandin G/H synthase 1 (-1) --------------------------------------------------- Drug1 : DB01056 Tocainide Drug2 : DB01182 Propafenone Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug2) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) --------------------------------------------------- Drug1 : DB01056 Tocainide Drug2 : DB01195 Flecainide Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug2) : BE0002083 Sodium channel protein type 4 subunit alpha (-1) --------------------------------------------------- Drug1 : DB01056 Tocainide Drug2 : DB01228 Encainide Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha --------------------------------------------------- Drug1 : DB01056 Tocainide Drug2 : DB01320 Fosphenytoin Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha --------------------------------------------------- Drug1 : DB01056 Tocainide Drug2 : DB01426 Ajmaline Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha --------------------------------------------------- Drug1 : DB01056 Tocainide Drug2 : DB01429 Aprindine Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug2) : BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB01062 Oxybutynin Drug2 : DB01148 Flavoxate Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) --------------------------------------------------- Drug1 : DB01062 Oxybutynin Drug2 : DB01231 Diphenidol Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 --------------------------------------------------- Drug1 : DB01062 Oxybutynin Drug2 : DB04843 Mepenzolate Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB01062 Oxybutynin Drug2 : DB08897 Aclidinium Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug2) : BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB01063 Acetophenazine Drug2 : DB01184 Domperidone Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000020 D(1A) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000581 D(3) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB01063 Acetophenazine Drug2 : DB01233 Metoclopramide Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000020 D(1A) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000092 Muscarinic acetylcholine receptor M1 (1) BE0000311 5-hydroxytryptamine receptor 3A (1) BE0000084 5-hydroxytryptamine receptor 4 (1) --------------------------------------------------- Drug1 : DB01063 Acetophenazine Drug2 : DB01425 Alizapride Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB01063 Acetophenazine Drug2 : DB01608 Propericiazine Pharmacological target (-,-) : BE0000020 D(1A) dopamine receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000575 Alpha-1B adrenergic receptor (-1) BE0000289 Alpha-2A adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB01063 Acetophenazine Drug2 : DB01614 Acepromazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Pharmacological target (-,-) : BE0000020 D(1A) dopamine receptor Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB01063 Acetophenazine Drug2 : DB01618 Molindone Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000020 D(1A) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB01063 Acetophenazine Drug2 : DB01621 Pipotiazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Pharmacological target (-,-) : BE0000020 D(1A) dopamine receptor Non-common off-target(s) (drug2) : BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB01063 Acetophenazine Drug2 : DB01623 Thiothixene Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Pharmacological target (-,-) : BE0000020 D(1A) dopamine receptor Non-common off-target(s) (drug2) : BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB01063 Acetophenazine Drug2 : DB01624 Zuclopenthixol Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Pharmacological target (-,-) : BE0000020 D(1A) dopamine receptor Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000145 D(1B) dopamine receptor (-1) BE0000289 Alpha-2A adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB01063 Acetophenazine Drug2 : DB04842 Fluspirilene Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000020 D(1A) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000679 Voltage-dependent calcium channel gamma-1 subunit (-1) --------------------------------------------------- Drug1 : DB01063 Acetophenazine Drug2 : DB06288 Amisulpride Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000020 D(1A) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000581 D(3) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB01063 Acetophenazine Drug2 : DB08815 Lurasidone Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000020 D(1A) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000342 Alpha-2C adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB01063 Acetophenazine Drug2 : DB09018 Bromopride Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000020 D(1A) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB01065 Melatonin Drug2 : DB06594 Agomelatine Pharmacological target (+,+) : BE0000515 Melatonin receptor type 1A Pharmacological target (+,+) : BE0000327 Melatonin receptor type 1B Non-common off-target(s) (drug1) : BE0001075 Myeloperoxidase (-1) BE0000123 Estrogen receptor (-1) BE0003554 Nuclear receptor ROR-beta (1) BE0003555 Eosinophil peroxidase (-1) Non-common off-target(s) (drug2) : BE0000533 5-hydroxytryptamine receptor 2C (-1) --------------------------------------------------- Drug1 : DB01065 Melatonin Drug2 : DB09071 Tasimelteon Pharmacological target (+,+) : BE0000515 Melatonin receptor type 1A Pharmacological target (+,+) : BE0000327 Melatonin receptor type 1B Non-common off-target(s) (drug1) : BE0001075 Myeloperoxidase (-1) BE0000123 Estrogen receptor (-1) BE0003554 Nuclear receptor ROR-beta (1) BE0003555 Eosinophil peroxidase (-1) --------------------------------------------------- Drug1 : DB01067 Glipizide Drug2 : DB01124 Tolbutamide Pharmacological target (-,-) : BE0000207 ATP-binding cassette sub-family C member 8 Non-common off-target(s) (drug1) : BE0000215 Peroxisome proliferator-activated receptor gamma (1) Non-common off-target(s) (drug2) : BE0000644 ATP-sensitive inward rectifier potassium channel 1 (-1) --------------------------------------------------- Drug1 : DB01067 Glipizide Drug2 : DB01251 Gliquidone Pharmacological target (-,-) : BE0000207 ATP-binding cassette sub-family C member 8 Non-common off-target(s) (drug1) : BE0000215 Peroxisome proliferator-activated receptor gamma (1) Non-common off-target(s) (drug2) : BE0002441 ATP-sensitive inward rectifier potassium channel 8 (-1) --------------------------------------------------- Drug1 : DB01068 Clonazepam Drug2 : DB01107 Methyprylon Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug2) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) --------------------------------------------------- Drug1 : DB01068 Clonazepam Drug2 : DB01159 Halothane Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug2) : BE0000534 Glutamate receptor ionotropic, NMDA 3B (-1) BE0000760 Glutamate receptor ionotropic, NMDA 2A (-1) BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000503 NADH-ubiquinone oxidoreductase chain 1 (-1) BE0000415 Intermediate conductance calcium-activated potassium channel protein 4 (-1) BE0000553 Calcium-activated potassium channel subunit alpha-1 (-1) BE0001028 G protein-activated inward rectifier potassium channel 1 (-1) BE0001030 G protein-activated inward rectifier potassium channel 2 (-1) --------------------------------------------------- Drug1 : DB01068 Clonazepam Drug2 : DB01437 Glutethimide Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug2) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) --------------------------------------------------- Drug1 : DB01069 Promethazine Drug2 : DB01071 Mequitazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB01069 Promethazine Drug2 : DB01075 Diphenhydramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB01069 Promethazine Drug2 : DB01084 Emedastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB01069 Promethazine Drug2 : DB01106 Levocabastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000418 Calmodulin (-1) Non-common off-target(s) (drug2) : BE0000464 Neurotensin receptor type 2 (-1) --------------------------------------------------- Drug1 : DB01069 Promethazine Drug2 : DB01114 Chlorphenamine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000418 Calmodulin (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB01069 Promethazine Drug2 : DB01146 Diphenylpyraline Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000418 Calmodulin (-1) Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB01069 Promethazine Drug2 : DB01176 Cyclizine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000418 Calmodulin (-1) Non-common off-target(s) (drug2) : BE0000951 Estrogen sulfotransferase (-1) --------------------------------------------------- Drug1 : DB01069 Promethazine Drug2 : DB01237 Bromodiphenhydramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB01069 Promethazine Drug2 : DB01246 Alimemazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB01069 Promethazine Drug2 : DB01615 Aceprometazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB01069 Promethazine Drug2 : DB01619 Phenindamine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB01069 Promethazine Drug2 : DB01620 Pheniramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB01069 Promethazine Drug2 : DB04837 Clofedanol Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB01069 Promethazine Drug2 : DB04890 Bepotastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB01069 Promethazine Drug2 : DB06691 Mepyramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB01069 Promethazine Drug2 : DB08799 Antazoline Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB01069 Promethazine Drug2 : DB08800 Chloropyramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB01069 Promethazine Drug2 : DB08802 Isothipendyl Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB01069 Promethazine Drug2 : DB08936 Chlorcyclizine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB01070 Dihydrotachysterol Drug2 : DB01436 Alfacalcidol Pharmacological target (+,+) : BE0000779 Vitamin D3 receptor --------------------------------------------------- Drug1 : DB01071 Mequitazine Drug2 : DB01075 Diphenhydramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB01071 Mequitazine Drug2 : DB01084 Emedastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB01071 Mequitazine Drug2 : DB01106 Levocabastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000464 Neurotensin receptor type 2 (-1) --------------------------------------------------- Drug1 : DB01071 Mequitazine Drug2 : DB01114 Chlorphenamine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB01071 Mequitazine Drug2 : DB01146 Diphenylpyraline Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB01071 Mequitazine Drug2 : DB01176 Cyclizine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000951 Estrogen sulfotransferase (-1) --------------------------------------------------- Drug1 : DB01071 Mequitazine Drug2 : DB01237 Bromodiphenhydramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB01071 Mequitazine Drug2 : DB01246 Alimemazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB01071 Mequitazine Drug2 : DB01615 Aceprometazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB01071 Mequitazine Drug2 : DB01619 Phenindamine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB01071 Mequitazine Drug2 : DB01620 Pheniramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB01071 Mequitazine Drug2 : DB04837 Clofedanol Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB01071 Mequitazine Drug2 : DB04890 Bepotastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB01071 Mequitazine Drug2 : DB06691 Mepyramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB01071 Mequitazine Drug2 : DB08799 Antazoline Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB01071 Mequitazine Drug2 : DB08800 Chloropyramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB01071 Mequitazine Drug2 : DB08801 Dimetindene Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB01071 Mequitazine Drug2 : DB08802 Isothipendyl Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB01071 Mequitazine Drug2 : DB08936 Chlorcyclizine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB01075 Diphenhydramine Drug2 : DB01084 Emedastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB01075 Diphenhydramine Drug2 : DB01106 Levocabastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000464 Neurotensin receptor type 2 (-1) --------------------------------------------------- Drug1 : DB01075 Diphenhydramine Drug2 : DB01114 Chlorphenamine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB01075 Diphenhydramine Drug2 : DB01146 Diphenylpyraline Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB01075 Diphenhydramine Drug2 : DB01176 Cyclizine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000951 Estrogen sulfotransferase (-1) --------------------------------------------------- Drug1 : DB01075 Diphenhydramine Drug2 : DB01237 Bromodiphenhydramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB01075 Diphenhydramine Drug2 : DB01246 Alimemazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB01075 Diphenhydramine Drug2 : DB01615 Aceprometazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB01075 Diphenhydramine Drug2 : DB01619 Phenindamine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB01075 Diphenhydramine Drug2 : DB01620 Pheniramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB01075 Diphenhydramine Drug2 : DB04837 Clofedanol Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB01075 Diphenhydramine Drug2 : DB04890 Bepotastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB01075 Diphenhydramine Drug2 : DB06691 Mepyramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB01075 Diphenhydramine Drug2 : DB08799 Antazoline Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB01075 Diphenhydramine Drug2 : DB08800 Chloropyramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB01075 Diphenhydramine Drug2 : DB08801 Dimetindene Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB01075 Diphenhydramine Drug2 : DB08802 Isothipendyl Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB01075 Diphenhydramine Drug2 : DB08936 Chlorcyclizine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB01076 Atorvastatin Drug2 : DB01095 Fluvastatin Pharmacological target (-,-) : BE0000574 3-hydroxy-3-methylglutaryl-coenzyme A reductase Non-common off-target(s) (drug1) : BE0003721 Aryl hydrocarbon receptor (1) BE0000854 Dipeptidyl peptidase 4 (-1) --------------------------------------------------- Drug1 : DB01076 Atorvastatin Drug2 : DB01098 Rosuvastatin Pharmacological target (-,-) : BE0000574 3-hydroxy-3-methylglutaryl-coenzyme A reductase Non-common off-target(s) (drug1) : BE0003721 Aryl hydrocarbon receptor (1) BE0000854 Dipeptidyl peptidase 4 (-1) --------------------------------------------------- Drug1 : DB01076 Atorvastatin Drug2 : DB06693 Mevastatin Pharmacological target (-,-) : BE0000574 3-hydroxy-3-methylglutaryl-coenzyme A reductase Non-common off-target(s) (drug1) : BE0003721 Aryl hydrocarbon receptor (1) BE0000854 Dipeptidyl peptidase 4 (-1) --------------------------------------------------- Drug1 : DB01076 Atorvastatin Drug2 : DB08860 Pitavastatin Pharmacological target (-,-) : BE0000574 3-hydroxy-3-methylglutaryl-coenzyme A reductase Non-common off-target(s) (drug1) : BE0003721 Aryl hydrocarbon receptor (1) BE0000854 Dipeptidyl peptidase 4 (-1) --------------------------------------------------- Drug1 : DB01078 Deslanoside Drug2 : DB01092 Ouabain Pharmacological target (-,-) : BE0000732 Sodium/potassium-transporting ATPase subunit alpha-1 --------------------------------------------------- Drug1 : DB01078 Deslanoside Drug2 : DB01158 Bretylium Pharmacological target (-,-) : BE0000732 Sodium/potassium-transporting ATPase subunit alpha-1 --------------------------------------------------- Drug1 : DB01078 Deslanoside Drug2 : DB01396 Digitoxin Pharmacological target (-,-) : BE0000732 Sodium/potassium-transporting ATPase subunit alpha-1 --------------------------------------------------- Drug1 : DB01080 Vigabatrin Drug2 : DB08891 Arbaclofen Pharmacological target (+,+) : BE0000217 Gamma-aminobutyric acid type B receptor subunit 1 Non-common off-target(s) (drug1) : BE0000253 4-aminobutyrate aminotransferase, mitochondrial (-1) Non-common off-target(s) (drug2) : BE0002340 Gamma-aminobutyric acid type B receptor subunit 2 (1) --------------------------------------------------- Drug1 : DB01080 Vigabatrin Drug2 : DB08892 Arbaclofen Placarbil Pharmacological target (+,+) : BE0000217 Gamma-aminobutyric acid type B receptor subunit 1 Non-common off-target(s) (drug1) : BE0000253 4-aminobutyrate aminotransferase, mitochondrial (-1) Non-common off-target(s) (drug2) : BE0002340 Gamma-aminobutyric acid type B receptor subunit 2 (1) --------------------------------------------------- Drug1 : DB01081 Diphenoxylate Drug2 : DB01209 Dezocine Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000420 Delta-type opioid receptor (1) Non-common off-target(s) (drug2) : BE0000632 Kappa-type opioid receptor (-1) --------------------------------------------------- Drug1 : DB01081 Diphenoxylate Drug2 : DB01227 Levomethadyl Acetate Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000420 Delta-type opioid receptor (1) Non-common off-target(s) (drug2) : BE0003585 Neuronal acetylcholine receptor subunit alpha-3 (-1) --------------------------------------------------- Drug1 : DB01081 Diphenoxylate Drug2 : DB01433 Methadyl Acetate Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000420 Delta-type opioid receptor (1) --------------------------------------------------- Drug1 : DB01081 Diphenoxylate Drug2 : DB01466 Ethylmorphine Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000420 Delta-type opioid receptor (1) --------------------------------------------------- Drug1 : DB01081 Diphenoxylate Drug2 : DB06204 Tapentadol Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000420 Delta-type opioid receptor (1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB01084 Emedastine Drug2 : DB01106 Levocabastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000464 Neurotensin receptor type 2 (-1) --------------------------------------------------- Drug1 : DB01084 Emedastine Drug2 : DB01114 Chlorphenamine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB01084 Emedastine Drug2 : DB01146 Diphenylpyraline Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB01084 Emedastine Drug2 : DB01176 Cyclizine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000951 Estrogen sulfotransferase (-1) --------------------------------------------------- Drug1 : DB01084 Emedastine Drug2 : DB01237 Bromodiphenhydramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB01084 Emedastine Drug2 : DB01246 Alimemazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB01084 Emedastine Drug2 : DB01615 Aceprometazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB01084 Emedastine Drug2 : DB01619 Phenindamine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB01084 Emedastine Drug2 : DB01620 Pheniramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB01084 Emedastine Drug2 : DB04837 Clofedanol Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB01084 Emedastine Drug2 : DB04890 Bepotastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB01084 Emedastine Drug2 : DB06691 Mepyramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB01084 Emedastine Drug2 : DB08799 Antazoline Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB01084 Emedastine Drug2 : DB08800 Chloropyramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB01084 Emedastine Drug2 : DB08801 Dimetindene Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB01084 Emedastine Drug2 : DB08802 Isothipendyl Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB01084 Emedastine Drug2 : DB08936 Chlorcyclizine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB01086 Benzocaine Drug2 : DB01161 Chloroprocaine Pharmacological target (-,-) : BE0000177 Sodium channel protein type 10 subunit alpha Non-common off-target(s) (drug2) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000411 Neuronal acetylcholine receptor subunit alpha-10 (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) --------------------------------------------------- Drug1 : DB01089 Deserpidine Drug2 : DB04844 Tetrabenazine Pharmacological target (-,-) : BE0000118 Synaptic vesicular amine transporter Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB01089 Deserpidine Drug2 : DB06706 Isometheptene Pharmacological target (-,-) : BE0000118 Synaptic vesicular amine transporter Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01092 Ouabain Drug2 : DB01158 Bretylium Pharmacological target (-,-) : BE0000732 Sodium/potassium-transporting ATPase subunit alpha-1 --------------------------------------------------- Drug1 : DB01092 Ouabain Drug2 : DB01396 Digitoxin Pharmacological target (-,-) : BE0000732 Sodium/potassium-transporting ATPase subunit alpha-1 --------------------------------------------------- Drug1 : DB01094 Hesperetin Drug2 : DB08827 Lomitapide Pharmacological target (-,-) : BE0000232 Microsomal triglyceride transfer protein large subunit Non-common off-target(s) (drug1) : BE0000105 Sterol O-acyltransferase 1 (-1) BE0004608 Sterol O-acyltransferase 2 (-1) --------------------------------------------------- Drug1 : DB01095 Fluvastatin Drug2 : DB01098 Rosuvastatin Pharmacological target (-,-) : BE0000574 3-hydroxy-3-methylglutaryl-coenzyme A reductase --------------------------------------------------- Drug1 : DB01095 Fluvastatin Drug2 : DB06693 Mevastatin Pharmacological target (-,-) : BE0000574 3-hydroxy-3-methylglutaryl-coenzyme A reductase --------------------------------------------------- Drug1 : DB01095 Fluvastatin Drug2 : DB08860 Pitavastatin Pharmacological target (-,-) : BE0000574 3-hydroxy-3-methylglutaryl-coenzyme A reductase --------------------------------------------------- Drug1 : DB01098 Rosuvastatin Drug2 : DB06693 Mevastatin Pharmacological target (-,-) : BE0000574 3-hydroxy-3-methylglutaryl-coenzyme A reductase --------------------------------------------------- Drug1 : DB01098 Rosuvastatin Drug2 : DB08860 Pitavastatin Pharmacological target (-,-) : BE0000574 3-hydroxy-3-methylglutaryl-coenzyme A reductase --------------------------------------------------- Drug1 : DB01100 Pimozide Drug2 : DB01184 Domperidone Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Pharmacological target (-,-) : BE0000581 D(3) dopamine receptor Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB01101 Capecitabine Drug2 : DB06813 Pralatrexate Pharmacological target (-,-) : BE0000324 Thymidylate synthase Non-common off-target(s) (drug2) : BE0000330 Dihydrofolate reductase (-1) --------------------------------------------------- Drug1 : DB01104 Sertraline Drug2 : DB01191 Dexfenfluramine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) Non-common off-target(s) (drug2) : BE0000533 5-hydroxytryptamine receptor 2C (1) --------------------------------------------------- Drug1 : DB01104 Sertraline Drug2 : DB04896 Milnacipran Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) Non-common off-target(s) (drug2) : BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0004956 NMDA receptor (-1) --------------------------------------------------- Drug1 : DB01104 Sertraline Drug2 : DB06700 Desvenlafaxine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) Non-common off-target(s) (drug2) : BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB01104 Sertraline Drug2 : DB08918 Levomilnacipran Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) Non-common off-target(s) (drug2) : BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB01105 Sibutramine Drug2 : DB01151 Desipramine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000694 Beta-2 adrenergic receptor (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000442 Histamine H1 receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0004863 Alpha-1 adrenergic receptor (-1) BE0000973 Sphingomyelin phosphodiesterase (-1) --------------------------------------------------- Drug1 : DB01105 Sibutramine Drug2 : DB01156 Bupropion Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) Non-common off-target(s) (drug2) : BE0003585 Neuronal acetylcholine receptor subunit alpha-3 (-1) --------------------------------------------------- Drug1 : DB01105 Sibutramine Drug2 : DB01576 Dextroamphetamine Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (1) BE0001044 Trace amine-associated receptor 1 (1) BE0000575 Alpha-1B adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB01105 Sibutramine Drug2 : DB04896 Milnacipran Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) Non-common off-target(s) (drug2) : BE0004956 NMDA receptor (-1) --------------------------------------------------- Drug1 : DB01105 Sibutramine Drug2 : DB06700 Desvenlafaxine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB01105 Sibutramine Drug2 : DB08918 Levomilnacipran Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB01106 Levocabastine Drug2 : DB01114 Chlorphenamine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000464 Neurotensin receptor type 2 (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB01106 Levocabastine Drug2 : DB01146 Diphenylpyraline Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000464 Neurotensin receptor type 2 (-1) Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB01106 Levocabastine Drug2 : DB01176 Cyclizine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000464 Neurotensin receptor type 2 (-1) Non-common off-target(s) (drug2) : BE0000951 Estrogen sulfotransferase (-1) --------------------------------------------------- Drug1 : DB01106 Levocabastine Drug2 : DB01237 Bromodiphenhydramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000464 Neurotensin receptor type 2 (-1) --------------------------------------------------- Drug1 : DB01106 Levocabastine Drug2 : DB01246 Alimemazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000464 Neurotensin receptor type 2 (-1) --------------------------------------------------- Drug1 : DB01106 Levocabastine Drug2 : DB01615 Aceprometazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000464 Neurotensin receptor type 2 (-1) --------------------------------------------------- Drug1 : DB01106 Levocabastine Drug2 : DB01619 Phenindamine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000464 Neurotensin receptor type 2 (-1) --------------------------------------------------- Drug1 : DB01106 Levocabastine Drug2 : DB01620 Pheniramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000464 Neurotensin receptor type 2 (-1) --------------------------------------------------- Drug1 : DB01106 Levocabastine Drug2 : DB04837 Clofedanol Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000464 Neurotensin receptor type 2 (-1) --------------------------------------------------- Drug1 : DB01106 Levocabastine Drug2 : DB04890 Bepotastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000464 Neurotensin receptor type 2 (-1) --------------------------------------------------- Drug1 : DB01106 Levocabastine Drug2 : DB06691 Mepyramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000464 Neurotensin receptor type 2 (-1) --------------------------------------------------- Drug1 : DB01106 Levocabastine Drug2 : DB08799 Antazoline Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000464 Neurotensin receptor type 2 (-1) --------------------------------------------------- Drug1 : DB01106 Levocabastine Drug2 : DB08800 Chloropyramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000464 Neurotensin receptor type 2 (-1) --------------------------------------------------- Drug1 : DB01106 Levocabastine Drug2 : DB08801 Dimetindene Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000464 Neurotensin receptor type 2 (-1) Non-common off-target(s) (drug2) : BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB01106 Levocabastine Drug2 : DB08802 Isothipendyl Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000464 Neurotensin receptor type 2 (-1) --------------------------------------------------- Drug1 : DB01106 Levocabastine Drug2 : DB08936 Chlorcyclizine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000464 Neurotensin receptor type 2 (-1) --------------------------------------------------- Drug1 : DB01107 Methyprylon Drug2 : DB01159 Halothane Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) Non-common off-target(s) (drug2) : BE0000534 Glutamate receptor ionotropic, NMDA 3B (-1) BE0000760 Glutamate receptor ionotropic, NMDA 2A (-1) BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000503 NADH-ubiquinone oxidoreductase chain 1 (-1) BE0000415 Intermediate conductance calcium-activated potassium channel protein 4 (-1) BE0000553 Calcium-activated potassium channel subunit alpha-1 (-1) BE0001028 G protein-activated inward rectifier potassium channel 1 (-1) BE0001030 G protein-activated inward rectifier potassium channel 2 (-1) --------------------------------------------------- Drug1 : DB01107 Methyprylon Drug2 : DB01174 Phenobarbital Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0004956 NMDA receptor (-1) --------------------------------------------------- Drug1 : DB01107 Methyprylon Drug2 : DB01341 Dihydroquinidine barbiturate Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) --------------------------------------------------- Drug1 : DB01107 Methyprylon Drug2 : DB01437 Glutethimide Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 --------------------------------------------------- Drug1 : DB01109 Heparin Drug2 : DB01225 Enoxaparin Pharmacological target (+,+) : BE0000280 Antithrombin-III Pharmacological target (-,-) : BE0000216 Coagulation factor X Non-common off-target(s) (drug1) : BE0001159 P-selectin (-1) --------------------------------------------------- Drug1 : DB01109 Heparin Drug2 : DB06228 Rivaroxaban Pharmacological target (-,-) : BE0000216 Coagulation factor X Non-common off-target(s) (drug1) : BE0000280 Antithrombin-III (1) BE0001159 P-selectin (-1) --------------------------------------------------- Drug1 : DB01109 Heparin Drug2 : DB06271 Sulodexide Pharmacological target (+,+) : BE0000280 Antithrombin-III Non-common off-target(s) (drug1) : BE0000216 Coagulation factor X (-1) BE0001159 P-selectin (-1) Non-common off-target(s) (drug2) : BE0000775 Heparin cofactor 2 (1) --------------------------------------------------- Drug1 : DB01109 Heparin Drug2 : DB06605 Apixaban Pharmacological target (-,-) : BE0000216 Coagulation factor X Non-common off-target(s) (drug1) : BE0000280 Antithrombin-III (1) BE0001159 P-selectin (-1) --------------------------------------------------- Drug1 : DB01109 Heparin Drug2 : DB06822 Tinzaparin Pharmacological target (+,+) : BE0000280 Antithrombin-III Non-common off-target(s) (drug1) : BE0000216 Coagulation factor X (-1) BE0001159 P-selectin (-1) Non-common off-target(s) (drug2) : BE0000590 Integrin alpha-4 (-1) --------------------------------------------------- Drug1 : DB01109 Heparin Drug2 : DB09075 Edoxaban Pharmacological target (-,-) : BE0000216 Coagulation factor X Non-common off-target(s) (drug1) : BE0000280 Antithrombin-III (1) BE0001159 P-selectin (-1) --------------------------------------------------- Drug1 : DB01114 Chlorphenamine Drug2 : DB01176 Cyclizine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) Non-common off-target(s) (drug2) : BE0000951 Estrogen sulfotransferase (-1) --------------------------------------------------- Drug1 : DB01114 Chlorphenamine Drug2 : DB01237 Bromodiphenhydramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB01114 Chlorphenamine Drug2 : DB01246 Alimemazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB01114 Chlorphenamine Drug2 : DB01615 Aceprometazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB01114 Chlorphenamine Drug2 : DB01619 Phenindamine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB01114 Chlorphenamine Drug2 : DB01620 Pheniramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB01114 Chlorphenamine Drug2 : DB04837 Clofedanol Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB01114 Chlorphenamine Drug2 : DB04890 Bepotastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB01114 Chlorphenamine Drug2 : DB06691 Mepyramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB01114 Chlorphenamine Drug2 : DB08799 Antazoline Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB01114 Chlorphenamine Drug2 : DB08800 Chloropyramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB01114 Chlorphenamine Drug2 : DB08801 Dimetindene Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) Non-common off-target(s) (drug2) : BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB01114 Chlorphenamine Drug2 : DB08802 Isothipendyl Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB01114 Chlorphenamine Drug2 : DB08936 Chlorcyclizine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB01119 Diazoxide Drug2 : DB01144 Diclofenamide Pharmacological target (-,-) : BE0000267 Carbonic anhydrase 1 Pharmacological target (-,-) : BE0000322 Carbonic anhydrase 2 Non-common off-target(s) (drug1) : BE0000708 ATP-sensitive inward rectifier potassium channel 11 (1) Non-common off-target(s) (drug2) : BE0000535 Carbonic anhydrase 4 (-1) BE0003629 Carbonic anhydrase 7 (-1) --------------------------------------------------- Drug1 : DB01121 Phenacemide Drug2 : DB01438 Phenazopyridine Pharmacological target (-,-) : BE0000141 Sodium channel protein type 1 subunit alpha --------------------------------------------------- Drug1 : DB01121 Phenacemide Drug2 : DB04930 Permethrin Pharmacological target (-,-) : BE0000141 Sodium channel protein type 1 subunit alpha --------------------------------------------------- Drug1 : DB01122 Ambenonium Drug2 : DB01400 Neostigmine Pharmacological target (-,-) : BE0000426 Acetylcholinesterase --------------------------------------------------- Drug1 : DB01122 Ambenonium Drug2 : DB08996 Dimetacrine Pharmacological target (-,-) : BE0000426 Acetylcholinesterase --------------------------------------------------- Drug1 : DB01124 Tolbutamide Drug2 : DB01251 Gliquidone Pharmacological target (-,-) : BE0000207 ATP-binding cassette sub-family C member 8 Non-common off-target(s) (drug1) : BE0000644 ATP-sensitive inward rectifier potassium channel 1 (-1) Non-common off-target(s) (drug2) : BE0002441 ATP-sensitive inward rectifier potassium channel 8 (-1) --------------------------------------------------- Drug1 : DB01124 Tolbutamide Drug2 : DB01252 Mitiglinide Pharmacological target (-,-) : BE0000207 ATP-binding cassette sub-family C member 8 Non-common off-target(s) (drug1) : BE0000644 ATP-sensitive inward rectifier potassium channel 1 (-1) Non-common off-target(s) (drug2) : BE0000215 Peroxisome proliferator-activated receptor gamma (1) --------------------------------------------------- Drug1 : DB01128 Bicalutamide Drug2 : DB04839 Cyproterone acetate Pharmacological target (-,-) : BE0000132 Androgen receptor --------------------------------------------------- Drug1 : DB01128 Bicalutamide Drug2 : DB08899 Enzalutamide Pharmacological target (-,-) : BE0000132 Androgen receptor --------------------------------------------------- Drug1 : DB01130 Prednicarbate Drug2 : DB01234 Dexamethasone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug2) : BE0000005 Nitric oxide synthase, inducible (-1) BE0000422 Annexin A1 (1) BE0000074 Nuclear receptor subfamily 0 group B member 1 (1) --------------------------------------------------- Drug1 : DB01130 Prednicarbate Drug2 : DB01260 Desonide Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB01130 Prednicarbate Drug2 : DB01380 Cortisone acetate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB01130 Prednicarbate Drug2 : DB01384 Paramethasone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB01130 Prednicarbate Drug2 : DB01410 Ciclesonide Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB01130 Prednicarbate Drug2 : DB06781 Difluprednate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB01130 Prednicarbate Drug2 : DB08906 Fluticasone furoate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB01131 Proguanil Drug2 : DB01157 Trimetrexate Pharmacological target (-,-) : BE0000330 Dihydrofolate reductase --------------------------------------------------- Drug1 : DB01131 Proguanil Drug2 : DB06813 Pralatrexate Pharmacological target (-,-) : BE0000330 Dihydrofolate reductase Non-common off-target(s) (drug2) : BE0000324 Thymidylate synthase (-1) --------------------------------------------------- Drug1 : DB01132 Pioglitazone Drug2 : DB08915 Aleglitazar Pharmacological target (+,+) : BE0000215 Peroxisome proliferator-activated receptor gamma Non-common off-target(s) (drug2) : BE0000071 Peroxisome proliferator-activated receptor alpha (1) --------------------------------------------------- Drug1 : DB01135 Doxacurium chloride Drug2 : DB01199 Tubocurarine Pharmacological target (-,-) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 Non-common off-target(s) (drug1) : BE0000560 Muscarinic acetylcholine receptor M2 (-1) Non-common off-target(s) (drug2) : BE0000426 Acetylcholinesterase (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) --------------------------------------------------- Drug1 : DB01135 Doxacurium chloride Drug2 : DB01226 Mivacurium Pharmacological target (-,-) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 Non-common off-target(s) (drug1) : BE0000560 Muscarinic acetylcholine receptor M2 (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) --------------------------------------------------- Drug1 : DB01135 Doxacurium chloride Drug2 : DB01339 Vecuronium Pharmacological target (-,-) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 Non-common off-target(s) (drug1) : BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB01136 Carvedilol Drug2 : DB01297 Practolol Pharmacological target (-,-) : BE0000172 Beta-1 adrenergic receptor Non-common off-target(s) (drug1) : BE0000173 NADH dehydrogenase [ubiquinone] 1 subunit C2 (-1) BE0000694 Beta-2 adrenergic receptor (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0001114 Vascular cell adhesion protein 1 (-1) BE0001074 E-selectin (-1) --------------------------------------------------- Drug1 : DB01137 Levofloxacin Drug2 : DB01177 Idarubicin Pharmacological target (-,-) : BE0000742 DNA topoisomerase 2-alpha --------------------------------------------------- Drug1 : DB01137 Levofloxacin Drug2 : DB01204 Mitoxantrone Pharmacological target (-,-) : BE0000742 DNA topoisomerase 2-alpha --------------------------------------------------- Drug1 : DB01137 Levofloxacin Drug2 : DB01208 Sparfloxacin Pharmacological target (-,-) : BE0000742 DNA topoisomerase 2-alpha --------------------------------------------------- Drug1 : DB01137 Levofloxacin Drug2 : DB04576 Fleroxacin Pharmacological target (-,-) : BE0000742 DNA topoisomerase 2-alpha --------------------------------------------------- Drug1 : DB01137 Levofloxacin Drug2 : DB09047 Finafloxacin Pharmacological target (-,-) : BE0000742 DNA topoisomerase 2-alpha --------------------------------------------------- Drug1 : DB01146 Diphenylpyraline Drug2 : DB01176 Cyclizine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) Non-common off-target(s) (drug2) : BE0000951 Estrogen sulfotransferase (-1) --------------------------------------------------- Drug1 : DB01146 Diphenylpyraline Drug2 : DB01237 Bromodiphenhydramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB01146 Diphenylpyraline Drug2 : DB01246 Alimemazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB01146 Diphenylpyraline Drug2 : DB01615 Aceprometazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB01146 Diphenylpyraline Drug2 : DB01619 Phenindamine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB01146 Diphenylpyraline Drug2 : DB01620 Pheniramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB01146 Diphenylpyraline Drug2 : DB04837 Clofedanol Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB01146 Diphenylpyraline Drug2 : DB04890 Bepotastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB01146 Diphenylpyraline Drug2 : DB06691 Mepyramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB01146 Diphenylpyraline Drug2 : DB08799 Antazoline Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB01146 Diphenylpyraline Drug2 : DB08800 Chloropyramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB01146 Diphenylpyraline Drug2 : DB08801 Dimetindene Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) Non-common off-target(s) (drug2) : BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB01146 Diphenylpyraline Drug2 : DB08802 Isothipendyl Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB01146 Diphenylpyraline Drug2 : DB08936 Chlorcyclizine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB01148 Flavoxate Drug2 : DB01231 Diphenidol Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) --------------------------------------------------- Drug1 : DB01148 Flavoxate Drug2 : DB04843 Mepenzolate Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000560 Muscarinic acetylcholine receptor M2 (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) --------------------------------------------------- Drug1 : DB01148 Flavoxate Drug2 : DB08801 Dimetindene Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) Non-common off-target(s) (drug2) : BE0000442 Histamine H1 receptor (-1) --------------------------------------------------- Drug1 : DB01149 Nefazodone Drug2 : DB01151 Desipramine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000694 Beta-2 adrenergic receptor (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000442 Histamine H1 receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0004863 Alpha-1 adrenergic receptor (-1) BE0000973 Sphingomyelin phosphodiesterase (-1) --------------------------------------------------- Drug1 : DB01151 Desipramine Drug2 : DB04896 Milnacipran Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000694 Beta-2 adrenergic receptor (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000442 Histamine H1 receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0004863 Alpha-1 adrenergic receptor (-1) BE0000973 Sphingomyelin phosphodiesterase (-1) Non-common off-target(s) (drug2) : BE0004956 NMDA receptor (-1) --------------------------------------------------- Drug1 : DB01151 Desipramine Drug2 : DB06700 Desvenlafaxine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000694 Beta-2 adrenergic receptor (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000442 Histamine H1 receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0004863 Alpha-1 adrenergic receptor (-1) BE0000973 Sphingomyelin phosphodiesterase (-1) --------------------------------------------------- Drug1 : DB01151 Desipramine Drug2 : DB08918 Levomilnacipran Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000694 Beta-2 adrenergic receptor (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000442 Histamine H1 receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0004863 Alpha-1 adrenergic receptor (-1) BE0000973 Sphingomyelin phosphodiesterase (-1) --------------------------------------------------- Drug1 : DB01156 Bupropion Drug2 : DB01255 Lisdexamfetamine Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Non-common off-target(s) (drug1) : BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0003585 Neuronal acetylcholine receptor subunit alpha-3 (-1) Non-common off-target(s) (drug2) : BE0000575 Alpha-1B adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB01156 Bupropion Drug2 : DB01463 Fencamfamine Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Non-common off-target(s) (drug1) : BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0003585 Neuronal acetylcholine receptor subunit alpha-3 (-1) --------------------------------------------------- Drug1 : DB01156 Bupropion Drug2 : DB01576 Dextroamphetamine Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0003585 Neuronal acetylcholine receptor subunit alpha-3 (-1) Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (1) BE0001044 Trace amine-associated receptor 1 (1) BE0000575 Alpha-1B adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB01156 Bupropion Drug2 : DB01579 Phendimetrazine Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0003585 Neuronal acetylcholine receptor subunit alpha-3 (-1) Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01156 Bupropion Drug2 : DB04896 Milnacipran Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0003585 Neuronal acetylcholine receptor subunit alpha-3 (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0004956 NMDA receptor (-1) --------------------------------------------------- Drug1 : DB01156 Bupropion Drug2 : DB06204 Tapentadol Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0003585 Neuronal acetylcholine receptor subunit alpha-3 (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000770 Mu-type opioid receptor (1) --------------------------------------------------- Drug1 : DB01156 Bupropion Drug2 : DB06700 Desvenlafaxine Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0003585 Neuronal acetylcholine receptor subunit alpha-3 (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) --------------------------------------------------- Drug1 : DB01156 Bupropion Drug2 : DB06701 Dexmethylphenidate Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0003585 Neuronal acetylcholine receptor subunit alpha-3 (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) --------------------------------------------------- Drug1 : DB01156 Bupropion Drug2 : DB08918 Levomilnacipran Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0003585 Neuronal acetylcholine receptor subunit alpha-3 (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) --------------------------------------------------- Drug1 : DB01157 Trimetrexate Drug2 : DB06813 Pralatrexate Pharmacological target (-,-) : BE0000330 Dihydrofolate reductase Non-common off-target(s) (drug2) : BE0000324 Thymidylate synthase (-1) --------------------------------------------------- Drug1 : DB01158 Bretylium Drug2 : DB01396 Digitoxin Pharmacological target (-,-) : BE0000732 Sodium/potassium-transporting ATPase subunit alpha-1 --------------------------------------------------- Drug1 : DB01159 Halothane Drug2 : DB01437 Glutethimide Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Non-common off-target(s) (drug1) : BE0000534 Glutamate receptor ionotropic, NMDA 3B (-1) BE0000760 Glutamate receptor ionotropic, NMDA 2A (-1) BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000503 NADH-ubiquinone oxidoreductase chain 1 (-1) BE0000415 Intermediate conductance calcium-activated potassium channel protein 4 (-1) BE0000553 Calcium-activated potassium channel subunit alpha-1 (-1) BE0001028 G protein-activated inward rectifier potassium channel 1 (-1) BE0001030 G protein-activated inward rectifier potassium channel 2 (-1) Non-common off-target(s) (drug2) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) --------------------------------------------------- Drug1 : DB01160 Dinoprost Tromethamine Drug2 : DB08819 Tafluprost Pharmacological target (+,+) : BE0000610 Prostaglandin F2-alpha receptor Non-common off-target(s) (drug1) : BE0000475 Prostacyclin receptor (-1) --------------------------------------------------- Drug1 : DB01166 Cilostazol Drug2 : DB01427 Amrinone Pharmacological target (-,-) : BE0000436 cGMP-inhibited 3',5'-cyclic phosphodiesterase A Non-common off-target(s) (drug2) : BE0000704 Tumor necrosis factor (-1) BE0000487 cAMP-specific 3',5'-cyclic phosphodiesterase 4B (-1) --------------------------------------------------- Drug1 : DB01166 Cilostazol Drug2 : DB04880 Enoximone Pharmacological target (-,-) : BE0000436 cGMP-inhibited 3',5'-cyclic phosphodiesterase A --------------------------------------------------- Drug1 : DB01170 Guanethidine Drug2 : DB04840 Debrisoquin Pharmacological target (+,+) : BE0000486 Sodium-dependent noradrenaline transporter --------------------------------------------------- Drug1 : DB01171 Moclobemide Drug2 : DB01247 Isocarboxazid Pharmacological target (-,-) : BE0002198 Amine oxidase [flavin-containing] A Non-common off-target(s) (drug2) : BE0002196 Amine oxidase [flavin-containing] B (-1) --------------------------------------------------- Drug1 : DB01174 Phenobarbital Drug2 : DB01341 Dihydroquinidine barbiturate Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0004956 NMDA receptor (-1) --------------------------------------------------- Drug1 : DB01174 Phenobarbital Drug2 : DB01437 Glutethimide Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0004956 NMDA receptor (-1) Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) --------------------------------------------------- Drug1 : DB01175 Escitalopram Drug2 : DB01191 Dexfenfluramine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) Non-common off-target(s) (drug2) : BE0000533 5-hydroxytryptamine receptor 2C (1) --------------------------------------------------- Drug1 : DB01176 Cyclizine Drug2 : DB01237 Bromodiphenhydramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000951 Estrogen sulfotransferase (-1) --------------------------------------------------- Drug1 : DB01176 Cyclizine Drug2 : DB01246 Alimemazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000951 Estrogen sulfotransferase (-1) --------------------------------------------------- Drug1 : DB01176 Cyclizine Drug2 : DB01615 Aceprometazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000951 Estrogen sulfotransferase (-1) --------------------------------------------------- Drug1 : DB01176 Cyclizine Drug2 : DB01619 Phenindamine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000951 Estrogen sulfotransferase (-1) --------------------------------------------------- Drug1 : DB01176 Cyclizine Drug2 : DB01620 Pheniramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000951 Estrogen sulfotransferase (-1) --------------------------------------------------- Drug1 : DB01176 Cyclizine Drug2 : DB04837 Clofedanol Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000951 Estrogen sulfotransferase (-1) --------------------------------------------------- Drug1 : DB01176 Cyclizine Drug2 : DB04890 Bepotastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000951 Estrogen sulfotransferase (-1) --------------------------------------------------- Drug1 : DB01176 Cyclizine Drug2 : DB06691 Mepyramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000951 Estrogen sulfotransferase (-1) --------------------------------------------------- Drug1 : DB01176 Cyclizine Drug2 : DB08799 Antazoline Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000951 Estrogen sulfotransferase (-1) --------------------------------------------------- Drug1 : DB01176 Cyclizine Drug2 : DB08800 Chloropyramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000951 Estrogen sulfotransferase (-1) --------------------------------------------------- Drug1 : DB01176 Cyclizine Drug2 : DB08801 Dimetindene Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000951 Estrogen sulfotransferase (-1) Non-common off-target(s) (drug2) : BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB01176 Cyclizine Drug2 : DB08802 Isothipendyl Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000951 Estrogen sulfotransferase (-1) --------------------------------------------------- Drug1 : DB01176 Cyclizine Drug2 : DB08936 Chlorcyclizine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000951 Estrogen sulfotransferase (-1) --------------------------------------------------- Drug1 : DB01177 Idarubicin Drug2 : DB01204 Mitoxantrone Pharmacological target (-,-) : BE0000742 DNA topoisomerase 2-alpha --------------------------------------------------- Drug1 : DB01177 Idarubicin Drug2 : DB01208 Sparfloxacin Pharmacological target (-,-) : BE0000742 DNA topoisomerase 2-alpha --------------------------------------------------- Drug1 : DB01177 Idarubicin Drug2 : DB04576 Fleroxacin Pharmacological target (-,-) : BE0000742 DNA topoisomerase 2-alpha --------------------------------------------------- Drug1 : DB01177 Idarubicin Drug2 : DB09047 Finafloxacin Pharmacological target (-,-) : BE0000742 DNA topoisomerase 2-alpha --------------------------------------------------- Drug1 : DB01180 Rescinnamine Drug2 : DB01197 Captopril Pharmacological target (-,-) : BE0000221 Angiotensin-converting enzyme Non-common off-target(s) (drug2) : BE0000642 72 kDa type IV collagenase (-1) BE0000058 Matrix metalloproteinase-9 (-1) --------------------------------------------------- Drug1 : DB01180 Rescinnamine Drug2 : DB01340 Cilazapril Pharmacological target (-,-) : BE0000221 Angiotensin-converting enzyme --------------------------------------------------- Drug1 : DB01180 Rescinnamine Drug2 : DB01348 Spirapril Pharmacological target (-,-) : BE0000221 Angiotensin-converting enzyme --------------------------------------------------- Drug1 : DB01182 Propafenone Drug2 : DB01195 Flecainide Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) Non-common off-target(s) (drug2) : BE0002083 Sodium channel protein type 4 subunit alpha (-1) --------------------------------------------------- Drug1 : DB01182 Propafenone Drug2 : DB01218 Halofantrine Pharmacological target (-,-) : BE0000090 Potassium voltage-gated channel subfamily H member 2 Non-common off-target(s) (drug1) : BE0000197 Sodium channel protein type 5 subunit alpha (-1) --------------------------------------------------- Drug1 : DB01182 Propafenone Drug2 : DB01228 Encainide Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) --------------------------------------------------- Drug1 : DB01182 Propafenone Drug2 : DB01320 Fosphenytoin Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) --------------------------------------------------- Drug1 : DB01182 Propafenone Drug2 : DB01426 Ajmaline Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) --------------------------------------------------- Drug1 : DB01182 Propafenone Drug2 : DB01429 Aprindine Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) Non-common off-target(s) (drug2) : BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB01184 Domperidone Drug2 : DB01233 Metoclopramide Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000581 D(3) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000092 Muscarinic acetylcholine receptor M1 (1) BE0000311 5-hydroxytryptamine receptor 3A (1) BE0000084 5-hydroxytryptamine receptor 4 (1) --------------------------------------------------- Drug1 : DB01184 Domperidone Drug2 : DB01425 Alizapride Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000581 D(3) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB01184 Domperidone Drug2 : DB01618 Molindone Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000581 D(3) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB01184 Domperidone Drug2 : DB04842 Fluspirilene Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000581 D(3) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000679 Voltage-dependent calcium channel gamma-1 subunit (-1) --------------------------------------------------- Drug1 : DB01184 Domperidone Drug2 : DB08815 Lurasidone Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000581 D(3) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000342 Alpha-2C adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB01184 Domperidone Drug2 : DB09018 Bromopride Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000581 D(3) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB01189 Desflurane Drug2 : DB01236 Sevoflurane Pharmacological target (+,+) : BE0000433 Glycine receptor subunit alpha-1 Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000781 Potassium voltage-gated channel subfamily A member 1 Pharmacological target (-,-) : BE0000640 Glutamate receptor 1 Pharmacological target (-,-) : BE0000218 Calcium-transporting ATPase type 2C member 1 Non-common off-target(s) (drug2) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) --------------------------------------------------- Drug1 : DB01191 Dexfenfluramine Drug2 : DB04896 Milnacipran Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (1) Non-common off-target(s) (drug2) : BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0004956 NMDA receptor (-1) --------------------------------------------------- Drug1 : DB01191 Dexfenfluramine Drug2 : DB06700 Desvenlafaxine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (1) Non-common off-target(s) (drug2) : BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB01191 Dexfenfluramine Drug2 : DB08918 Levomilnacipran Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (1) Non-common off-target(s) (drug2) : BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB01192 Oxymorphone Drug2 : DB01209 Dezocine Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000420 Delta-type opioid receptor (-1) Non-common off-target(s) (drug2) : BE0000632 Kappa-type opioid receptor (-1) --------------------------------------------------- Drug1 : DB01192 Oxymorphone Drug2 : DB01227 Levomethadyl Acetate Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000420 Delta-type opioid receptor (-1) Non-common off-target(s) (drug2) : BE0003585 Neuronal acetylcholine receptor subunit alpha-3 (-1) --------------------------------------------------- Drug1 : DB01192 Oxymorphone Drug2 : DB01433 Methadyl Acetate Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000420 Delta-type opioid receptor (-1) --------------------------------------------------- Drug1 : DB01192 Oxymorphone Drug2 : DB01466 Ethylmorphine Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000420 Delta-type opioid receptor (-1) --------------------------------------------------- Drug1 : DB01192 Oxymorphone Drug2 : DB06204 Tapentadol Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000420 Delta-type opioid receptor (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB01195 Flecainide Drug2 : DB01228 Encainide Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0002083 Sodium channel protein type 4 subunit alpha (-1) --------------------------------------------------- Drug1 : DB01195 Flecainide Drug2 : DB01320 Fosphenytoin Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0002083 Sodium channel protein type 4 subunit alpha (-1) --------------------------------------------------- Drug1 : DB01195 Flecainide Drug2 : DB01426 Ajmaline Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0002083 Sodium channel protein type 4 subunit alpha (-1) --------------------------------------------------- Drug1 : DB01195 Flecainide Drug2 : DB01429 Aprindine Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug1) : BE0002083 Sodium channel protein type 4 subunit alpha (-1) Non-common off-target(s) (drug2) : BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB01197 Captopril Drug2 : DB01340 Cilazapril Pharmacological target (-,-) : BE0000221 Angiotensin-converting enzyme Non-common off-target(s) (drug1) : BE0000642 72 kDa type IV collagenase (-1) BE0000058 Matrix metalloproteinase-9 (-1) --------------------------------------------------- Drug1 : DB01197 Captopril Drug2 : DB01348 Spirapril Pharmacological target (-,-) : BE0000221 Angiotensin-converting enzyme Non-common off-target(s) (drug1) : BE0000642 72 kDa type IV collagenase (-1) BE0000058 Matrix metalloproteinase-9 (-1) --------------------------------------------------- Drug1 : DB01198 Zopiclone Drug2 : DB01346 Quinidine barbiturate Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Non-common off-target(s) (drug1) : BE0000736 Translocator protein (1) BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 (1) BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000197 Sodium channel protein type 5 subunit alpha (-1) BE0000154 Potassium channel subfamily K member 1 (-1) --------------------------------------------------- Drug1 : DB01198 Zopiclone Drug2 : DB01351 Amobarbital Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000736 Translocator protein (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB01198 Zopiclone Drug2 : DB01352 Aprobarbital Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000736 Translocator protein (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB01198 Zopiclone Drug2 : DB01353 Butethal Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000736 Translocator protein (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB01198 Zopiclone Drug2 : DB01354 Heptabarbital Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000736 Translocator protein (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB01198 Zopiclone Drug2 : DB01355 Hexobarbital Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000736 Translocator protein (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB01198 Zopiclone Drug2 : DB01483 Barbital Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000736 Translocator protein (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB01198 Zopiclone Drug2 : DB01496 Barbituric acid derivative Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Non-common off-target(s) (drug1) : BE0000736 Translocator protein (1) Non-common off-target(s) (drug2) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) --------------------------------------------------- Drug1 : DB01199 Tubocurarine Drug2 : DB01226 Mivacurium Pharmacological target (-,-) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 Non-common off-target(s) (drug1) : BE0000426 Acetylcholinesterase (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) --------------------------------------------------- Drug1 : DB01199 Tubocurarine Drug2 : DB01336 Metocurine Pharmacological target (-,-) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 Non-common off-target(s) (drug1) : BE0000426 Acetylcholinesterase (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) Non-common off-target(s) (drug2) : BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB01199 Tubocurarine Drug2 : DB01337 Pancuronium Pharmacological target (-,-) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 Non-common off-target(s) (drug1) : BE0000426 Acetylcholinesterase (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB01199 Tubocurarine Drug2 : DB01338 Pipecuronium Pharmacological target (-,-) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 Non-common off-target(s) (drug1) : BE0000426 Acetylcholinesterase (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB01199 Tubocurarine Drug2 : DB01339 Vecuronium Pharmacological target (-,-) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 Non-common off-target(s) (drug1) : BE0000426 Acetylcholinesterase (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) --------------------------------------------------- Drug1 : DB01203 Nadolol Drug2 : DB01297 Practolol Pharmacological target (-,-) : BE0000172 Beta-1 adrenergic receptor Non-common off-target(s) (drug1) : BE0000694 Beta-2 adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB01204 Mitoxantrone Drug2 : DB01208 Sparfloxacin Pharmacological target (-,-) : BE0000742 DNA topoisomerase 2-alpha --------------------------------------------------- Drug1 : DB01204 Mitoxantrone Drug2 : DB04576 Fleroxacin Pharmacological target (-,-) : BE0000742 DNA topoisomerase 2-alpha --------------------------------------------------- Drug1 : DB01204 Mitoxantrone Drug2 : DB09047 Finafloxacin Pharmacological target (-,-) : BE0000742 DNA topoisomerase 2-alpha --------------------------------------------------- Drug1 : DB01208 Sparfloxacin Drug2 : DB04576 Fleroxacin Pharmacological target (-,-) : BE0000742 DNA topoisomerase 2-alpha --------------------------------------------------- Drug1 : DB01208 Sparfloxacin Drug2 : DB09047 Finafloxacin Pharmacological target (-,-) : BE0000742 DNA topoisomerase 2-alpha --------------------------------------------------- Drug1 : DB01209 Dezocine Drug2 : DB01227 Levomethadyl Acetate Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (-1) Non-common off-target(s) (drug2) : BE0003585 Neuronal acetylcholine receptor subunit alpha-3 (-1) --------------------------------------------------- Drug1 : DB01209 Dezocine Drug2 : DB01433 Methadyl Acetate Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (-1) --------------------------------------------------- Drug1 : DB01209 Dezocine Drug2 : DB01444 Dimethylthiambutene Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (-1) Non-common off-target(s) (drug2) : BE0000420 Delta-type opioid receptor (1) --------------------------------------------------- Drug1 : DB01209 Dezocine Drug2 : DB01466 Ethylmorphine Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (-1) --------------------------------------------------- Drug1 : DB01209 Dezocine Drug2 : DB06204 Tapentadol Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB01210 Levobunolol Drug2 : DB01214 Metipranolol Pharmacological target (-,-) : BE0000172 Beta-1 adrenergic receptor Pharmacological target (-,-) : BE0000694 Beta-2 adrenergic receptor --------------------------------------------------- Drug1 : DB01210 Levobunolol Drug2 : DB01297 Practolol Pharmacological target (-,-) : BE0000172 Beta-1 adrenergic receptor Non-common off-target(s) (drug1) : BE0000694 Beta-2 adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB01214 Metipranolol Drug2 : DB01297 Practolol Pharmacological target (-,-) : BE0000172 Beta-1 adrenergic receptor Non-common off-target(s) (drug1) : BE0000694 Beta-2 adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB01215 Estazolam Drug2 : DB01558 Bromazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Pharmacological target (+,+) : BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Pharmacological target (+,+) : BE0003596 Gamma-aminobutyric acid receptor subunit pi Pharmacological target (+,+) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Pharmacological target (+,+) : BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 Pharmacological target (+,+) : BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) Non-common off-target(s) (drug2) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB01215 Estazolam Drug2 : DB01559 Clotiazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Pharmacological target (+,+) : BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Pharmacological target (+,+) : BE0003596 Gamma-aminobutyric acid receptor subunit pi Pharmacological target (+,+) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Pharmacological target (+,+) : BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 Pharmacological target (+,+) : BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) --------------------------------------------------- Drug1 : DB01215 Estazolam Drug2 : DB01567 Fludiazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Pharmacological target (+,+) : BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Pharmacological target (+,+) : BE0003596 Gamma-aminobutyric acid receptor subunit pi Pharmacological target (+,+) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Pharmacological target (+,+) : BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 Pharmacological target (+,+) : BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) --------------------------------------------------- Drug1 : DB01215 Estazolam Drug2 : DB01588 Prazepam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Pharmacological target (+,+) : BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Pharmacological target (+,+) : BE0003596 Gamma-aminobutyric acid receptor subunit pi Pharmacological target (+,+) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Pharmacological target (+,+) : BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 Pharmacological target (+,+) : BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 --------------------------------------------------- Drug1 : DB01215 Estazolam Drug2 : DB01589 Quazepam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Pharmacological target (+,+) : BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Pharmacological target (+,+) : BE0003596 Gamma-aminobutyric acid receptor subunit pi Pharmacological target (+,+) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Pharmacological target (+,+) : BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 Pharmacological target (+,+) : BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 Non-common off-target(s) (drug1) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) --------------------------------------------------- Drug1 : DB01215 Estazolam Drug2 : DB01594 Cinolazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Pharmacological target (+,+) : BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Pharmacological target (+,+) : BE0003596 Gamma-aminobutyric acid receptor subunit pi Pharmacological target (+,+) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Pharmacological target (+,+) : BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 Pharmacological target (+,+) : BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) --------------------------------------------------- Drug1 : DB01215 Estazolam Drug2 : DB01595 Nitrazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Pharmacological target (+,+) : BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Pharmacological target (+,+) : BE0003596 Gamma-aminobutyric acid receptor subunit pi Pharmacological target (+,+) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Pharmacological target (+,+) : BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 Pharmacological target (+,+) : BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) Non-common off-target(s) (drug2) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB01221 Ketamine Drug2 : DB03575 Phencyclidine Pharmacological target (-,-) : BE0000641 Glutamate receptor ionotropic, NMDA 3A Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (1) BE0000632 Kappa-type opioid receptor (1) BE0000384 Substance-P receptor (-1) BE0004957 5-hydroxytryptamine receptor 2 (-1) BE0004958 5-hydroxytryptamine receptor 1 (-1) --------------------------------------------------- Drug1 : DB01223 Aminophylline Drug2 : DB01303 Oxtriphylline Pharmacological target (+,+) : BE0002366 Histone deacetylase 2 Pharmacological target (-,-) : BE0000013 Adenosine receptor A1 Pharmacological target (-,-) : BE0000436 cGMP-inhibited 3',5'-cyclic phosphodiesterase A Non-common off-target(s) (drug1) : BE0000354 Adenosine receptor A3 (-1) Non-common off-target(s) (drug2) : BE0000924 Adenosine receptor A2a (-1) BE0001133 cAMP-specific 3',5'-cyclic phosphodiesterase 4A (-1) --------------------------------------------------- Drug1 : DB01224 Quetiapine Drug2 : DB01425 Alizapride Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000145 D(1B) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB01224 Quetiapine Drug2 : DB09018 Bromopride Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000145 D(1B) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB01225 Enoxaparin Drug2 : DB06228 Rivaroxaban Pharmacological target (-,-) : BE0000216 Coagulation factor X Non-common off-target(s) (drug1) : BE0000280 Antithrombin-III (1) --------------------------------------------------- Drug1 : DB01225 Enoxaparin Drug2 : DB06271 Sulodexide Pharmacological target (+,+) : BE0000280 Antithrombin-III Non-common off-target(s) (drug1) : BE0000216 Coagulation factor X (-1) Non-common off-target(s) (drug2) : BE0000775 Heparin cofactor 2 (1) --------------------------------------------------- Drug1 : DB01225 Enoxaparin Drug2 : DB06605 Apixaban Pharmacological target (-,-) : BE0000216 Coagulation factor X Non-common off-target(s) (drug1) : BE0000280 Antithrombin-III (1) --------------------------------------------------- Drug1 : DB01225 Enoxaparin Drug2 : DB06822 Tinzaparin Pharmacological target (+,+) : BE0000280 Antithrombin-III Non-common off-target(s) (drug1) : BE0000216 Coagulation factor X (-1) Non-common off-target(s) (drug2) : BE0000590 Integrin alpha-4 (-1) --------------------------------------------------- Drug1 : DB01225 Enoxaparin Drug2 : DB08813 Nadroparin Pharmacological target (+,+) : BE0000280 Antithrombin-III Non-common off-target(s) (drug1) : BE0000216 Coagulation factor X (-1) Non-common off-target(s) (drug2) : BE0001159 P-selectin (-1) BE0001126 Proto-oncogene c-Fos (-1) BE0004689 Myc proto-oncogene protein (-1) --------------------------------------------------- Drug1 : DB01225 Enoxaparin Drug2 : DB09075 Edoxaban Pharmacological target (-,-) : BE0000216 Coagulation factor X Non-common off-target(s) (drug1) : BE0000280 Antithrombin-III (1) --------------------------------------------------- Drug1 : DB01226 Mivacurium Drug2 : DB01336 Metocurine Pharmacological target (-,-) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) Non-common off-target(s) (drug2) : BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB01226 Mivacurium Drug2 : DB01339 Vecuronium Pharmacological target (-,-) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) --------------------------------------------------- Drug1 : DB01227 Levomethadyl Acetate Drug2 : DB01433 Methadyl Acetate Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0003585 Neuronal acetylcholine receptor subunit alpha-3 (-1) --------------------------------------------------- Drug1 : DB01227 Levomethadyl Acetate Drug2 : DB01444 Dimethylthiambutene Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0003585 Neuronal acetylcholine receptor subunit alpha-3 (-1) Non-common off-target(s) (drug2) : BE0000420 Delta-type opioid receptor (1) --------------------------------------------------- Drug1 : DB01227 Levomethadyl Acetate Drug2 : DB01452 Heroin Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0003585 Neuronal acetylcholine receptor subunit alpha-3 (-1) Non-common off-target(s) (drug2) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) --------------------------------------------------- Drug1 : DB01227 Levomethadyl Acetate Drug2 : DB01466 Ethylmorphine Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0003585 Neuronal acetylcholine receptor subunit alpha-3 (-1) --------------------------------------------------- Drug1 : DB01227 Levomethadyl Acetate Drug2 : DB01535 Carfentanil Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0003585 Neuronal acetylcholine receptor subunit alpha-3 (-1) Non-common off-target(s) (drug2) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) --------------------------------------------------- Drug1 : DB01227 Levomethadyl Acetate Drug2 : DB01565 Dihydromorphine Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0003585 Neuronal acetylcholine receptor subunit alpha-3 (-1) Non-common off-target(s) (drug2) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) BE0000947 Pro-opiomelanocortin (1) BE0001063 E3 ubiquitin-protein ligase TRIM13 (1) --------------------------------------------------- Drug1 : DB01227 Levomethadyl Acetate Drug2 : DB06204 Tapentadol Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0003585 Neuronal acetylcholine receptor subunit alpha-3 (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB01228 Encainide Drug2 : DB01320 Fosphenytoin Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha --------------------------------------------------- Drug1 : DB01228 Encainide Drug2 : DB01426 Ajmaline Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha --------------------------------------------------- Drug1 : DB01228 Encainide Drug2 : DB01429 Aprindine Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug2) : BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB01229 Paclitaxel Drug2 : DB01394 Colchicine Pharmacological target (-,-) : BE0000026 Tubulin beta-1 chain Non-common off-target(s) (drug1) : BE0000956 Nuclear receptor subfamily 1 group I member 2 (1) BE0000246 Apoptosis regulator Bcl-2 (-1) Non-common off-target(s) (drug2) : BE0000143 Tubulin beta chain (-1) --------------------------------------------------- Drug1 : DB01231 Diphenidol Drug2 : DB04843 Mepenzolate Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB01231 Diphenidol Drug2 : DB08897 Aclidinium Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Pharmacological target (-,-) : BE0000092 Muscarinic acetylcholine receptor M1 Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug2) : BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB01233 Metoclopramide Drug2 : DB01425 Alizapride Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (1) BE0000311 5-hydroxytryptamine receptor 3A (1) BE0000084 5-hydroxytryptamine receptor 4 (1) --------------------------------------------------- Drug1 : DB01233 Metoclopramide Drug2 : DB01618 Molindone Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (1) BE0000311 5-hydroxytryptamine receptor 3A (1) BE0000084 5-hydroxytryptamine receptor 4 (1) Non-common off-target(s) (drug2) : BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB01233 Metoclopramide Drug2 : DB04842 Fluspirilene Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (1) BE0000311 5-hydroxytryptamine receptor 3A (1) BE0000084 5-hydroxytryptamine receptor 4 (1) Non-common off-target(s) (drug2) : BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000679 Voltage-dependent calcium channel gamma-1 subunit (-1) --------------------------------------------------- Drug1 : DB01233 Metoclopramide Drug2 : DB04946 Iloperidone Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (1) BE0000311 5-hydroxytryptamine receptor 3A (1) BE0000084 5-hydroxytryptamine receptor 4 (1) Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) BE0000342 Alpha-2C adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB01233 Metoclopramide Drug2 : DB06216 Asenapine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (1) BE0000311 5-hydroxytryptamine receptor 3A (1) BE0000084 5-hydroxytryptamine receptor 4 (1) Non-common off-target(s) (drug2) : BE0000172 Beta-1 adrenergic receptor (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000694 Beta-2 adrenergic receptor (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000797 5-hydroxytryptamine receptor 1B (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000112 Histamine H2 receptor (-1) BE0004688 5-hydroxytryptamine receptor 5A (-1) --------------------------------------------------- Drug1 : DB01233 Metoclopramide Drug2 : DB06288 Amisulpride Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (1) BE0000311 5-hydroxytryptamine receptor 3A (1) BE0000084 5-hydroxytryptamine receptor 4 (1) Non-common off-target(s) (drug2) : BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000581 D(3) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB01233 Metoclopramide Drug2 : DB08815 Lurasidone Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (1) BE0000311 5-hydroxytryptamine receptor 3A (1) BE0000084 5-hydroxytryptamine receptor 4 (1) Non-common off-target(s) (drug2) : BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000342 Alpha-2C adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB01233 Metoclopramide Drug2 : DB09018 Bromopride Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (1) BE0000311 5-hydroxytryptamine receptor 3A (1) BE0000084 5-hydroxytryptamine receptor 4 (1) --------------------------------------------------- Drug1 : DB01234 Dexamethasone Drug2 : DB01260 Desonide Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug1) : BE0000005 Nitric oxide synthase, inducible (-1) BE0000422 Annexin A1 (1) BE0000074 Nuclear receptor subfamily 0 group B member 1 (1) --------------------------------------------------- Drug1 : DB01234 Dexamethasone Drug2 : DB01380 Cortisone acetate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug1) : BE0000005 Nitric oxide synthase, inducible (-1) BE0000422 Annexin A1 (1) BE0000074 Nuclear receptor subfamily 0 group B member 1 (1) --------------------------------------------------- Drug1 : DB01234 Dexamethasone Drug2 : DB01384 Paramethasone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug1) : BE0000005 Nitric oxide synthase, inducible (-1) BE0000422 Annexin A1 (1) BE0000074 Nuclear receptor subfamily 0 group B member 1 (1) --------------------------------------------------- Drug1 : DB01234 Dexamethasone Drug2 : DB01410 Ciclesonide Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug1) : BE0000005 Nitric oxide synthase, inducible (-1) BE0000422 Annexin A1 (1) BE0000074 Nuclear receptor subfamily 0 group B member 1 (1) --------------------------------------------------- Drug1 : DB01234 Dexamethasone Drug2 : DB06781 Difluprednate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug1) : BE0000005 Nitric oxide synthase, inducible (-1) BE0000422 Annexin A1 (1) BE0000074 Nuclear receptor subfamily 0 group B member 1 (1) --------------------------------------------------- Drug1 : DB01234 Dexamethasone Drug2 : DB08906 Fluticasone furoate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor Non-common off-target(s) (drug1) : BE0000005 Nitric oxide synthase, inducible (-1) BE0000422 Annexin A1 (1) BE0000074 Nuclear receptor subfamily 0 group B member 1 (1) --------------------------------------------------- Drug1 : DB01237 Bromodiphenhydramine Drug2 : DB01246 Alimemazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB01237 Bromodiphenhydramine Drug2 : DB01615 Aceprometazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB01237 Bromodiphenhydramine Drug2 : DB01619 Phenindamine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB01237 Bromodiphenhydramine Drug2 : DB01620 Pheniramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB01237 Bromodiphenhydramine Drug2 : DB04837 Clofedanol Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB01237 Bromodiphenhydramine Drug2 : DB04890 Bepotastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB01237 Bromodiphenhydramine Drug2 : DB06691 Mepyramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB01237 Bromodiphenhydramine Drug2 : DB08799 Antazoline Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB01237 Bromodiphenhydramine Drug2 : DB08800 Chloropyramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB01237 Bromodiphenhydramine Drug2 : DB08801 Dimetindene Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB01237 Bromodiphenhydramine Drug2 : DB08802 Isothipendyl Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB01237 Bromodiphenhydramine Drug2 : DB08936 Chlorcyclizine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB01238 Aripiprazole Drug2 : DB08810 Cinitapride Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000659 5-hydroxytryptamine receptor 1D (-1) BE0000797 5-hydroxytryptamine receptor 1B (-1) BE0000476 5-hydroxytryptamine receptor 1E (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) Non-common off-target(s) (drug2) : BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000084 5-hydroxytryptamine receptor 4 (1) --------------------------------------------------- Drug1 : DB01239 Chlorprothixene Drug2 : DB01242 Clomipramine Pharmacological target (-,-) : BE0000533 5-hydroxytryptamine receptor 2C Pharmacological target (-,-) : BE0000393 5-hydroxytryptamine receptor 2B Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000442 Histamine H1 receptor (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) Non-common off-target(s) (drug2) : BE0000814 Glutathione S-transferase P (-1) BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB01239 Chlorprothixene Drug2 : DB01614 Acepromazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Pharmacological target (-,-) : BE0000020 D(1A) dopamine receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000442 Histamine H1 receptor (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000581 D(3) dopamine receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) --------------------------------------------------- Drug1 : DB01239 Chlorprothixene Drug2 : DB01621 Pipotiazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Pharmacological target (-,-) : BE0000020 D(1A) dopamine receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000442 Histamine H1 receptor (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000581 D(3) dopamine receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) Non-common off-target(s) (drug2) : BE0000291 5-hydroxytryptamine receptor 1A (-1) --------------------------------------------------- Drug1 : DB01239 Chlorprothixene Drug2 : DB01623 Thiothixene Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Pharmacological target (-,-) : BE0000020 D(1A) dopamine receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000442 Histamine H1 receptor (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000581 D(3) dopamine receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB01239 Chlorprothixene Drug2 : DB06144 Sertindole Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Pharmacological target (-,-) : BE0000533 5-hydroxytryptamine receptor 2C Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000442 Histamine H1 receptor (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) Non-common off-target(s) (drug2) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) --------------------------------------------------- Drug1 : DB01241 Gemfibrozil Drug2 : DB08915 Aleglitazar Pharmacological target (+,+) : BE0000071 Peroxisome proliferator-activated receptor alpha Non-common off-target(s) (drug2) : BE0000215 Peroxisome proliferator-activated receptor gamma (1) --------------------------------------------------- Drug1 : DB01242 Clomipramine Drug2 : DB06144 Sertindole Pharmacological target (-,-) : BE0000533 5-hydroxytryptamine receptor 2C Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000814 Glutathione S-transferase P (-1) BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) --------------------------------------------------- Drug1 : DB01242 Clomipramine Drug2 : DB09016 Butriptyline Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000814 Glutathione S-transferase P (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) Non-common off-target(s) (drug2) : BE0000442 Histamine H1 receptor (-1) --------------------------------------------------- Drug1 : DB01246 Alimemazine Drug2 : DB01615 Aceprometazine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB01246 Alimemazine Drug2 : DB01619 Phenindamine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB01246 Alimemazine Drug2 : DB01620 Pheniramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB01246 Alimemazine Drug2 : DB04837 Clofedanol Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB01246 Alimemazine Drug2 : DB04890 Bepotastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB01246 Alimemazine Drug2 : DB06691 Mepyramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB01246 Alimemazine Drug2 : DB08799 Antazoline Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB01246 Alimemazine Drug2 : DB08800 Chloropyramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB01246 Alimemazine Drug2 : DB08801 Dimetindene Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB01246 Alimemazine Drug2 : DB08802 Isothipendyl Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB01246 Alimemazine Drug2 : DB08936 Chlorcyclizine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB01247 Isocarboxazid Drug2 : DB01367 Rasagiline Pharmacological target (-,-) : BE0002196 Amine oxidase [flavin-containing] B Non-common off-target(s) (drug1) : BE0002198 Amine oxidase [flavin-containing] A (-1) Non-common off-target(s) (drug2) : BE0000246 Apoptosis regulator Bcl-2 (1) --------------------------------------------------- Drug1 : DB01251 Gliquidone Drug2 : DB01252 Mitiglinide Pharmacological target (-,-) : BE0000207 ATP-binding cassette sub-family C member 8 Non-common off-target(s) (drug1) : BE0002441 ATP-sensitive inward rectifier potassium channel 8 (-1) Non-common off-target(s) (drug2) : BE0000215 Peroxisome proliferator-activated receptor gamma (1) --------------------------------------------------- Drug1 : DB01251 Gliquidone Drug2 : DB01289 Glisoxepide Pharmacological target (-,-) : BE0002441 ATP-sensitive inward rectifier potassium channel 8 Non-common off-target(s) (drug1) : BE0000207 ATP-binding cassette sub-family C member 8 (-1) --------------------------------------------------- Drug1 : DB01253 Ergonovine Drug2 : DB01579 Phendimetrazine Pharmacological target (+,+) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug2) : BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000575 Alpha-1B adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01253 Ergonovine Drug2 : DB06706 Isometheptene Pharmacological target (+,+) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (-1) --------------------------------------------------- Drug1 : DB01253 Ergonovine Drug2 : DB06707 Levonordefrin Pharmacological target (+,+) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug2) : BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB01253 Ergonovine Drug2 : DB06711 Naphazoline Pharmacological target (+,+) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug2) : BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01255 Lisdexamfetamine Drug2 : DB01463 Fencamfamine Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Non-common off-target(s) (drug1) : BE0000575 Alpha-1B adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB01255 Lisdexamfetamine Drug2 : DB06701 Dexmethylphenidate Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Non-common off-target(s) (drug1) : BE0000575 Alpha-1B adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB01259 Lapatinib Drug2 : DB01269 Panitumumab Pharmacological target (-,-) : BE0000767 Epidermal growth factor receptor Non-common off-target(s) (drug1) : BE0000511 Receptor tyrosine-protein kinase erbB-2 (-1) --------------------------------------------------- Drug1 : DB01259 Lapatinib Drug2 : DB08916 Afatinib Pharmacological target (-,-) : BE0000767 Epidermal growth factor receptor Pharmacological target (-,-) : BE0000511 Receptor tyrosine-protein kinase erbB-2 Non-common off-target(s) (drug2) : BE0004772 Receptor tyrosine-protein kinase erbB-4 (-1) --------------------------------------------------- Drug1 : DB01260 Desonide Drug2 : DB01380 Cortisone acetate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB01260 Desonide Drug2 : DB01384 Paramethasone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB01260 Desonide Drug2 : DB01410 Ciclesonide Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB01260 Desonide Drug2 : DB06781 Difluprednate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB01260 Desonide Drug2 : DB08906 Fluticasone furoate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB01261 Sitagliptin Drug2 : DB04876 Vildagliptin Pharmacological target (-,-) : BE0000854 Dipeptidyl peptidase 4 --------------------------------------------------- Drug1 : DB01261 Sitagliptin Drug2 : DB06203 Alogliptin Pharmacological target (-,-) : BE0000854 Dipeptidyl peptidase 4 --------------------------------------------------- Drug1 : DB01261 Sitagliptin Drug2 : DB06335 Saxagliptin Pharmacological target (-,-) : BE0000854 Dipeptidyl peptidase 4 --------------------------------------------------- Drug1 : DB01261 Sitagliptin Drug2 : DB08882 Linagliptin Pharmacological target (-,-) : BE0000854 Dipeptidyl peptidase 4 --------------------------------------------------- Drug1 : DB01267 Paliperidone Drug2 : DB06144 Sertindole Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Pharmacological target (-,-) : BE0000533 5-hydroxytryptamine receptor 2C Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000442 Histamine H1 receptor (1) BE0000659 5-hydroxytryptamine receptor 1D (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) --------------------------------------------------- Drug1 : DB01274 Arformoterol Drug2 : DB01288 Fenoterol Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug2) : BE0000172 Beta-1 adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01274 Arformoterol Drug2 : DB01291 Pirbuterol Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug2) : BE0000172 Beta-1 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01274 Arformoterol Drug2 : DB01366 Procaterol Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor --------------------------------------------------- Drug1 : DB01274 Arformoterol Drug2 : DB01407 Clenbuterol Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug2) : BE0000172 Beta-1 adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) BE0001094 Beta-nerve growth factor (1) --------------------------------------------------- Drug1 : DB01274 Arformoterol Drug2 : DB01408 Bambuterol Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor --------------------------------------------------- Drug1 : DB01274 Arformoterol Drug2 : DB05039 Indacaterol Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor --------------------------------------------------- Drug1 : DB01274 Arformoterol Drug2 : DB09080 Olodaterol Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor --------------------------------------------------- Drug1 : DB01276 Exenatide Drug2 : DB06655 Liraglutide Pharmacological target (+,+) : BE0000857 Glucagon-like peptide 1 receptor --------------------------------------------------- Drug1 : DB01276 Exenatide Drug2 : DB09043 Albiglutide Pharmacological target (+,+) : BE0000857 Glucagon-like peptide 1 receptor --------------------------------------------------- Drug1 : DB01276 Exenatide Drug2 : DB09045 Dulaglutide Pharmacological target (+,+) : BE0000857 Glucagon-like peptide 1 receptor --------------------------------------------------- Drug1 : DB01283 Lumiracoxib Drug2 : DB01397 Magnesium salicylate Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 --------------------------------------------------- Drug1 : DB01283 Lumiracoxib Drug2 : DB01398 Salicylate-sodium Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 --------------------------------------------------- Drug1 : DB01283 Lumiracoxib Drug2 : DB01399 Salsalate Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 --------------------------------------------------- Drug1 : DB01283 Lumiracoxib Drug2 : DB01600 Tiaprofenic acid Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 --------------------------------------------------- Drug1 : DB01283 Lumiracoxib Drug2 : DB01628 Etoricoxib Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) --------------------------------------------------- Drug1 : DB01283 Lumiracoxib Drug2 : DB04552 Niflumic Acid Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) Non-common off-target(s) (drug2) : BE0003997 Phospholipase A2 (-1) BE0002376 Chloride channel protein ClC-Ka (1) --------------------------------------------------- Drug1 : DB01283 Lumiracoxib Drug2 : DB04743 Nimesulide Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) --------------------------------------------------- Drug1 : DB01283 Lumiracoxib Drug2 : DB06725 Lornoxicam Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 --------------------------------------------------- Drug1 : DB01288 Fenoterol Drug2 : DB01366 Procaterol Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0000172 Beta-1 adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01288 Fenoterol Drug2 : DB01408 Bambuterol Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0000172 Beta-1 adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01288 Fenoterol Drug2 : DB05039 Indacaterol Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0000172 Beta-1 adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01288 Fenoterol Drug2 : DB09080 Olodaterol Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0000172 Beta-1 adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01291 Pirbuterol Drug2 : DB01366 Procaterol Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0000172 Beta-1 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01291 Pirbuterol Drug2 : DB01408 Bambuterol Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0000172 Beta-1 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01291 Pirbuterol Drug2 : DB05039 Indacaterol Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0000172 Beta-1 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01291 Pirbuterol Drug2 : DB09080 Olodaterol Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0000172 Beta-1 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01295 Bevantolol Drug2 : DB01297 Practolol Pharmacological target (-,-) : BE0000172 Beta-1 adrenergic receptor Non-common off-target(s) (drug1) : BE0000694 Beta-2 adrenergic receptor (-1) BE0000501 Alpha-1A adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB01297 Practolol Drug2 : DB01580 Oxprenolol Pharmacological target (-,-) : BE0000172 Beta-1 adrenergic receptor Non-common off-target(s) (drug2) : BE0000694 Beta-2 adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB01297 Practolol Drug2 : DB04861 Nebivolol Pharmacological target (-,-) : BE0000172 Beta-1 adrenergic receptor Non-common off-target(s) (drug2) : BE0000694 Beta-2 adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB01297 Practolol Drug2 : DB08808 Bupranolol Pharmacological target (-,-) : BE0000172 Beta-1 adrenergic receptor Non-common off-target(s) (drug2) : BE0000694 Beta-2 adrenergic receptor (-1) BE0001012 Beta-3 adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB01306 Insulin Aspart Drug2 : DB01307 Insulin Detemir Pharmacological target (+,+) : BE0000033 Insulin receptor --------------------------------------------------- Drug1 : DB01306 Insulin Aspart Drug2 : DB01309 Insulin Glulisine Pharmacological target (+,+) : BE0000033 Insulin receptor --------------------------------------------------- Drug1 : DB01306 Insulin Aspart Drug2 : DB08914 Insulin, isophane Pharmacological target (+,+) : BE0000033 Insulin receptor --------------------------------------------------- Drug1 : DB01307 Insulin Detemir Drug2 : DB01309 Insulin Glulisine Pharmacological target (+,+) : BE0000033 Insulin receptor --------------------------------------------------- Drug1 : DB01307 Insulin Detemir Drug2 : DB08914 Insulin, isophane Pharmacological target (+,+) : BE0000033 Insulin receptor --------------------------------------------------- Drug1 : DB01309 Insulin Glulisine Drug2 : DB08914 Insulin, isophane Pharmacological target (+,+) : BE0000033 Insulin receptor --------------------------------------------------- Drug1 : DB01320 Fosphenytoin Drug2 : DB01426 Ajmaline Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha --------------------------------------------------- Drug1 : DB01320 Fosphenytoin Drug2 : DB01429 Aprindine Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug2) : BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB01336 Metocurine Drug2 : DB01339 Vecuronium Pharmacological target (-,-) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 Non-common off-target(s) (drug1) : BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB01337 Pancuronium Drug2 : DB01339 Vecuronium Pharmacological target (-,-) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB01338 Pipecuronium Drug2 : DB01339 Vecuronium Pharmacological target (-,-) : BE0000738 Neuronal acetylcholine receptor subunit alpha-2 Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB01340 Cilazapril Drug2 : DB01348 Spirapril Pharmacological target (-,-) : BE0000221 Angiotensin-converting enzyme --------------------------------------------------- Drug1 : DB01341 Dihydroquinidine barbiturate Drug2 : DB01437 Glutethimide Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) --------------------------------------------------- Drug1 : DB01342 Forasartan Drug2 : DB01347 Saprisartan Pharmacological target (-,-) : BE0000062 Type-1 angiotensin II receptor --------------------------------------------------- Drug1 : DB01342 Forasartan Drug2 : DB01349 Tasosartan Pharmacological target (-,-) : BE0000062 Type-1 angiotensin II receptor Non-common off-target(s) (drug2) : BE0003426 Type-2 angiotensin II receptor (-1) --------------------------------------------------- Drug1 : DB01342 Forasartan Drug2 : DB08822 Azilsartan medoxomil Pharmacological target (-,-) : BE0000062 Type-1 angiotensin II receptor --------------------------------------------------- Drug1 : DB01347 Saprisartan Drug2 : DB01349 Tasosartan Pharmacological target (-,-) : BE0000062 Type-1 angiotensin II receptor Non-common off-target(s) (drug2) : BE0003426 Type-2 angiotensin II receptor (-1) --------------------------------------------------- Drug1 : DB01347 Saprisartan Drug2 : DB08822 Azilsartan medoxomil Pharmacological target (-,-) : BE0000062 Type-1 angiotensin II receptor --------------------------------------------------- Drug1 : DB01349 Tasosartan Drug2 : DB08822 Azilsartan medoxomil Pharmacological target (-,-) : BE0000062 Type-1 angiotensin II receptor Non-common off-target(s) (drug1) : BE0003426 Type-2 angiotensin II receptor (-1) --------------------------------------------------- Drug1 : DB01351 Amobarbital Drug2 : DB01544 Flunitrazepam Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) Non-common off-target(s) (drug2) : BE0000736 Translocator protein (1) --------------------------------------------------- Drug1 : DB01352 Aprobarbital Drug2 : DB01544 Flunitrazepam Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) Non-common off-target(s) (drug2) : BE0000736 Translocator protein (1) --------------------------------------------------- Drug1 : DB01353 Butethal Drug2 : DB01544 Flunitrazepam Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) Non-common off-target(s) (drug2) : BE0000736 Translocator protein (1) --------------------------------------------------- Drug1 : DB01354 Heptabarbital Drug2 : DB01544 Flunitrazepam Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) Non-common off-target(s) (drug2) : BE0000736 Translocator protein (1) --------------------------------------------------- Drug1 : DB01355 Hexobarbital Drug2 : DB01544 Flunitrazepam Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) Non-common off-target(s) (drug2) : BE0000736 Translocator protein (1) --------------------------------------------------- Drug1 : DB01357 Mestranol Drug2 : DB04573 Estriol Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug2) : BE0000792 Estrogen receptor beta (1) --------------------------------------------------- Drug1 : DB01357 Mestranol Drug2 : DB04574 Estropipate Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug2) : BE0000792 Estrogen receptor beta (1) --------------------------------------------------- Drug1 : DB01357 Mestranol Drug2 : DB04575 Quinestrol Pharmacological target (+,+) : BE0000123 Estrogen receptor --------------------------------------------------- Drug1 : DB01359 Penbutolol Drug2 : DB01616 Alverine Pharmacological target (-,-) : BE0000291 5-hydroxytryptamine receptor 1A Non-common off-target(s) (drug1) : BE0000797 5-hydroxytryptamine receptor 1B (-1) --------------------------------------------------- Drug1 : DB01363 Ephedra Drug2 : DB01442 MMDA Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000118 Synaptic vesicular amine transporter Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Pharmacological target (-,-) : BE0002196 Amine oxidase [flavin-containing] B Pharmacological target (-,-) : BE0002198 Amine oxidase [flavin-containing] A Pharmacological target (-,-) : BE0004674 Chromaffin granule amine transporter Non-common off-target(s) (drug1) : BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000451 5-hydroxytryptamine receptor 2A (1) --------------------------------------------------- Drug1 : DB01363 Ephedra Drug2 : DB01577 Methamphetamine Pharmacological target (+,+) : BE0000289 Alpha-2A adrenergic receptor Pharmacological target (+,+) : BE0000572 Alpha-2B adrenergic receptor Pharmacological target (+,+) : BE0000342 Alpha-2C adrenergic receptor Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000118 Synaptic vesicular amine transporter Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Pharmacological target (-,-) : BE0002196 Amine oxidase [flavin-containing] B Pharmacological target (-,-) : BE0002198 Amine oxidase [flavin-containing] A Pharmacological target (-,-) : BE0004674 Chromaffin granule amine transporter Non-common off-target(s) (drug1) : BE0000172 Beta-1 adrenergic receptor (1) BE0000694 Beta-2 adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0001044 Trace amine-associated receptor 1 (1) --------------------------------------------------- Drug1 : DB01366 Procaterol Drug2 : DB01407 Clenbuterol Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug2) : BE0000172 Beta-1 adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) BE0001094 Beta-nerve growth factor (1) --------------------------------------------------- Drug1 : DB01366 Procaterol Drug2 : DB01408 Bambuterol Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor --------------------------------------------------- Drug1 : DB01366 Procaterol Drug2 : DB05039 Indacaterol Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor --------------------------------------------------- Drug1 : DB01366 Procaterol Drug2 : DB09080 Olodaterol Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor --------------------------------------------------- Drug1 : DB01367 Rasagiline Drug2 : DB01626 Pargyline Pharmacological target (-,-) : BE0002196 Amine oxidase [flavin-containing] B Non-common off-target(s) (drug1) : BE0000246 Apoptosis regulator Bcl-2 (1) Non-common off-target(s) (drug2) : BE0002198 Amine oxidase [flavin-containing] A (-1) --------------------------------------------------- Drug1 : DB01380 Cortisone acetate Drug2 : DB01384 Paramethasone Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB01380 Cortisone acetate Drug2 : DB01410 Ciclesonide Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB01380 Cortisone acetate Drug2 : DB06781 Difluprednate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB01380 Cortisone acetate Drug2 : DB08906 Fluticasone furoate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB01384 Paramethasone Drug2 : DB01410 Ciclesonide Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB01384 Paramethasone Drug2 : DB06781 Difluprednate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB01384 Paramethasone Drug2 : DB08906 Fluticasone furoate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB01393 Bezafibrate Drug2 : DB08915 Aleglitazar Pharmacological target (+,+) : BE0000215 Peroxisome proliferator-activated receptor gamma Pharmacological target (+,+) : BE0000071 Peroxisome proliferator-activated receptor alpha Non-common off-target(s) (drug1) : BE0001007 Peroxisome proliferator-activated receptor delta (1) --------------------------------------------------- Drug1 : DB01397 Magnesium salicylate Drug2 : DB01398 Salicylate-sodium Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 --------------------------------------------------- Drug1 : DB01397 Magnesium salicylate Drug2 : DB01399 Salsalate Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 --------------------------------------------------- Drug1 : DB01397 Magnesium salicylate Drug2 : DB01600 Tiaprofenic acid Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 --------------------------------------------------- Drug1 : DB01397 Magnesium salicylate Drug2 : DB01628 Etoricoxib Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) --------------------------------------------------- Drug1 : DB01397 Magnesium salicylate Drug2 : DB04552 Niflumic Acid Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) Non-common off-target(s) (drug2) : BE0003997 Phospholipase A2 (-1) BE0002376 Chloride channel protein ClC-Ka (1) --------------------------------------------------- Drug1 : DB01397 Magnesium salicylate Drug2 : DB04743 Nimesulide Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) --------------------------------------------------- Drug1 : DB01397 Magnesium salicylate Drug2 : DB06725 Lornoxicam Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 --------------------------------------------------- Drug1 : DB01398 Salicylate-sodium Drug2 : DB01399 Salsalate Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 --------------------------------------------------- Drug1 : DB01398 Salicylate-sodium Drug2 : DB01600 Tiaprofenic acid Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 --------------------------------------------------- Drug1 : DB01398 Salicylate-sodium Drug2 : DB01628 Etoricoxib Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) --------------------------------------------------- Drug1 : DB01398 Salicylate-sodium Drug2 : DB04552 Niflumic Acid Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) Non-common off-target(s) (drug2) : BE0003997 Phospholipase A2 (-1) BE0002376 Chloride channel protein ClC-Ka (1) --------------------------------------------------- Drug1 : DB01398 Salicylate-sodium Drug2 : DB04743 Nimesulide Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) --------------------------------------------------- Drug1 : DB01398 Salicylate-sodium Drug2 : DB06725 Lornoxicam Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 --------------------------------------------------- Drug1 : DB01399 Salsalate Drug2 : DB01600 Tiaprofenic acid Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 --------------------------------------------------- Drug1 : DB01399 Salsalate Drug2 : DB01628 Etoricoxib Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) --------------------------------------------------- Drug1 : DB01399 Salsalate Drug2 : DB04552 Niflumic Acid Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) Non-common off-target(s) (drug2) : BE0003997 Phospholipase A2 (-1) BE0002376 Chloride channel protein ClC-Ka (1) --------------------------------------------------- Drug1 : DB01399 Salsalate Drug2 : DB04743 Nimesulide Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) --------------------------------------------------- Drug1 : DB01399 Salsalate Drug2 : DB06725 Lornoxicam Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 --------------------------------------------------- Drug1 : DB01400 Neostigmine Drug2 : DB08996 Dimetacrine Pharmacological target (-,-) : BE0000426 Acetylcholinesterase --------------------------------------------------- Drug1 : DB01403 Methotrimeprazine Drug2 : DB01425 Alizapride Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000145 D(1B) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB01403 Methotrimeprazine Drug2 : DB09018 Bromopride Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000145 D(1B) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB01407 Clenbuterol Drug2 : DB01408 Bambuterol Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0000172 Beta-1 adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) BE0001094 Beta-nerve growth factor (1) --------------------------------------------------- Drug1 : DB01407 Clenbuterol Drug2 : DB05039 Indacaterol Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0000172 Beta-1 adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) BE0001094 Beta-nerve growth factor (1) --------------------------------------------------- Drug1 : DB01407 Clenbuterol Drug2 : DB09080 Olodaterol Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor Non-common off-target(s) (drug1) : BE0000172 Beta-1 adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) BE0001094 Beta-nerve growth factor (1) --------------------------------------------------- Drug1 : DB01408 Bambuterol Drug2 : DB05039 Indacaterol Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor --------------------------------------------------- Drug1 : DB01408 Bambuterol Drug2 : DB09080 Olodaterol Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor --------------------------------------------------- Drug1 : DB01409 Tiotropium Drug2 : DB01625 Isopropamide Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Non-common off-target(s) (drug1) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) Non-common off-target(s) (drug2) : BE0000405 Muscarinic acetylcholine receptor M4 (-1) --------------------------------------------------- Drug1 : DB01410 Ciclesonide Drug2 : DB06781 Difluprednate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB01410 Ciclesonide Drug2 : DB08906 Fluticasone furoate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB01420 Testosterone Propionate Drug2 : DB01481 Delta1-dihydrotestosterone Pharmacological target (+,+) : BE0000132 Androgen receptor --------------------------------------------------- Drug1 : DB01420 Testosterone Propionate Drug2 : DB01541 Boldenone Pharmacological target (+,+) : BE0000132 Androgen receptor --------------------------------------------------- Drug1 : DB01420 Testosterone Propionate Drug2 : DB06710 Methyltestosterone Pharmacological target (+,+) : BE0000132 Androgen receptor --------------------------------------------------- Drug1 : DB01420 Testosterone Propionate Drug2 : DB08804 Nandrolone decanoate Pharmacological target (+,+) : BE0000132 Androgen receptor --------------------------------------------------- Drug1 : DB01425 Alizapride Drug2 : DB01618 Molindone Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug2) : BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB01425 Alizapride Drug2 : DB04842 Fluspirilene Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug2) : BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000679 Voltage-dependent calcium channel gamma-1 subunit (-1) --------------------------------------------------- Drug1 : DB01425 Alizapride Drug2 : DB04946 Iloperidone Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) BE0000342 Alpha-2C adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB01425 Alizapride Drug2 : DB06216 Asenapine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug2) : BE0000172 Beta-1 adrenergic receptor (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000694 Beta-2 adrenergic receptor (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000797 5-hydroxytryptamine receptor 1B (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000112 Histamine H2 receptor (-1) BE0004688 5-hydroxytryptamine receptor 5A (-1) --------------------------------------------------- Drug1 : DB01425 Alizapride Drug2 : DB06288 Amisulpride Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug2) : BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000581 D(3) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB01425 Alizapride Drug2 : DB08815 Lurasidone Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug2) : BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000342 Alpha-2C adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB01425 Alizapride Drug2 : DB09018 Bromopride Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor --------------------------------------------------- Drug1 : DB01426 Ajmaline Drug2 : DB01429 Aprindine Pharmacological target (-,-) : BE0000197 Sodium channel protein type 5 subunit alpha Non-common off-target(s) (drug2) : BE0000418 Calmodulin (-1) --------------------------------------------------- Drug1 : DB01427 Amrinone Drug2 : DB04880 Enoximone Pharmacological target (-,-) : BE0000436 cGMP-inhibited 3',5'-cyclic phosphodiesterase A Non-common off-target(s) (drug1) : BE0000704 Tumor necrosis factor (-1) BE0000487 cAMP-specific 3',5'-cyclic phosphodiesterase 4B (-1) --------------------------------------------------- Drug1 : DB01431 Allylestrenol Drug2 : DB06713 Norelgestromin Pharmacological target (+,+) : BE0000557 Progesterone receptor Non-common off-target(s) (drug1) : BE0000123 Estrogen receptor (1) --------------------------------------------------- Drug1 : DB01433 Methadyl Acetate Drug2 : DB01444 Dimethylthiambutene Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug2) : BE0000420 Delta-type opioid receptor (1) --------------------------------------------------- Drug1 : DB01433 Methadyl Acetate Drug2 : DB01452 Heroin Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug2) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) --------------------------------------------------- Drug1 : DB01433 Methadyl Acetate Drug2 : DB01466 Ethylmorphine Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor --------------------------------------------------- Drug1 : DB01433 Methadyl Acetate Drug2 : DB01535 Carfentanil Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug2) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) --------------------------------------------------- Drug1 : DB01433 Methadyl Acetate Drug2 : DB01565 Dihydromorphine Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug2) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) BE0000947 Pro-opiomelanocortin (1) BE0001063 E3 ubiquitin-protein ligase TRIM13 (1) --------------------------------------------------- Drug1 : DB01433 Methadyl Acetate Drug2 : DB06204 Tapentadol Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB01438 Phenazopyridine Drug2 : DB04930 Permethrin Pharmacological target (-,-) : BE0000141 Sodium channel protein type 1 subunit alpha --------------------------------------------------- Drug1 : DB01439 3-Methylthiofentanyl Drug2 : DB01497 Etorphine Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Pharmacological target (+,+) : BE0000632 Kappa-type opioid receptor Pharmacological target (+,+) : BE0000420 Delta-type opioid receptor Non-common off-target(s) (drug2) : BE0002378 Nociceptin receptor (1) BE0001063 E3 ubiquitin-protein ligase TRIM13 (1) --------------------------------------------------- Drug1 : DB01439 3-Methylthiofentanyl Drug2 : DB01571 3-Methylfentanyl Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Pharmacological target (+,+) : BE0000632 Kappa-type opioid receptor Pharmacological target (+,+) : BE0000420 Delta-type opioid receptor --------------------------------------------------- Drug1 : DB01439 3-Methylthiofentanyl Drug2 : DB06738 Ketobemidone Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Pharmacological target (+,+) : BE0000632 Kappa-type opioid receptor Pharmacological target (+,+) : BE0000420 Delta-type opioid receptor Non-common off-target(s) (drug2) : BE0004956 NMDA receptor (-1) --------------------------------------------------- Drug1 : DB01442 MMDA Drug2 : DB01577 Methamphetamine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000118 Synaptic vesicular amine transporter Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Pharmacological target (-,-) : BE0002196 Amine oxidase [flavin-containing] B Pharmacological target (-,-) : BE0002198 Amine oxidase [flavin-containing] A Pharmacological target (-,-) : BE0004674 Chromaffin granule amine transporter Non-common off-target(s) (drug1) : BE0000451 5-hydroxytryptamine receptor 2A (1) Non-common off-target(s) (drug2) : BE0001044 Trace amine-associated receptor 1 (1) BE0000289 Alpha-2A adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01444 Dimethylthiambutene Drug2 : DB01466 Ethylmorphine Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000420 Delta-type opioid receptor (1) --------------------------------------------------- Drug1 : DB01444 Dimethylthiambutene Drug2 : DB06204 Tapentadol Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000420 Delta-type opioid receptor (1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB01452 Heroin Drug2 : DB01466 Ethylmorphine Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) --------------------------------------------------- Drug1 : DB01452 Heroin Drug2 : DB06204 Tapentadol Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB01454 3,4-Methylenedioxymethamphetamine Drug2 : DB04896 Milnacipran Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000533 5-hydroxytryptamine receptor 2C (1) BE0000393 5-hydroxytryptamine receptor 2B (1) BE0000451 5-hydroxytryptamine receptor 2A (1) Non-common off-target(s) (drug2) : BE0004956 NMDA receptor (-1) --------------------------------------------------- Drug1 : DB01454 3,4-Methylenedioxymethamphetamine Drug2 : DB06700 Desvenlafaxine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000533 5-hydroxytryptamine receptor 2C (1) BE0000393 5-hydroxytryptamine receptor 2B (1) BE0000451 5-hydroxytryptamine receptor 2A (1) --------------------------------------------------- Drug1 : DB01454 3,4-Methylenedioxymethamphetamine Drug2 : DB08918 Levomilnacipran Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000533 5-hydroxytryptamine receptor 2C (1) BE0000393 5-hydroxytryptamine receptor 2B (1) BE0000451 5-hydroxytryptamine receptor 2A (1) --------------------------------------------------- Drug1 : DB01463 Fencamfamine Drug2 : DB06701 Dexmethylphenidate Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB01466 Ethylmorphine Drug2 : DB01535 Carfentanil Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug2) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) --------------------------------------------------- Drug1 : DB01466 Ethylmorphine Drug2 : DB01565 Dihydromorphine Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug2) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) BE0000947 Pro-opiomelanocortin (1) BE0001063 E3 ubiquitin-protein ligase TRIM13 (1) --------------------------------------------------- Drug1 : DB01466 Ethylmorphine Drug2 : DB06204 Tapentadol Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB01481 Delta1-dihydrotestosterone Drug2 : DB01541 Boldenone Pharmacological target (+,+) : BE0000132 Androgen receptor --------------------------------------------------- Drug1 : DB01481 Delta1-dihydrotestosterone Drug2 : DB06710 Methyltestosterone Pharmacological target (+,+) : BE0000132 Androgen receptor --------------------------------------------------- Drug1 : DB01481 Delta1-dihydrotestosterone Drug2 : DB08804 Nandrolone decanoate Pharmacological target (+,+) : BE0000132 Androgen receptor --------------------------------------------------- Drug1 : DB01483 Barbital Drug2 : DB01544 Flunitrazepam Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) Non-common off-target(s) (drug2) : BE0000736 Translocator protein (1) --------------------------------------------------- Drug1 : DB01496 Barbituric acid derivative Drug2 : DB01544 Flunitrazepam Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Non-common off-target(s) (drug1) : BE0000829 Glutamate receptor 2 (-1) BE0000826 Glutamate receptor ionotropic, kainate 2 (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (1) Non-common off-target(s) (drug2) : BE0000736 Translocator protein (1) --------------------------------------------------- Drug1 : DB01497 Etorphine Drug2 : DB01571 3-Methylfentanyl Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Pharmacological target (+,+) : BE0000632 Kappa-type opioid receptor Pharmacological target (+,+) : BE0000420 Delta-type opioid receptor Non-common off-target(s) (drug1) : BE0002378 Nociceptin receptor (1) BE0001063 E3 ubiquitin-protein ligase TRIM13 (1) --------------------------------------------------- Drug1 : DB01497 Etorphine Drug2 : DB06738 Ketobemidone Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Pharmacological target (+,+) : BE0000632 Kappa-type opioid receptor Pharmacological target (+,+) : BE0000420 Delta-type opioid receptor Non-common off-target(s) (drug1) : BE0002378 Nociceptin receptor (1) BE0001063 E3 ubiquitin-protein ligase TRIM13 (1) Non-common off-target(s) (drug2) : BE0004956 NMDA receptor (-1) --------------------------------------------------- Drug1 : DB01535 Carfentanil Drug2 : DB06204 Tapentadol Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB01541 Boldenone Drug2 : DB06710 Methyltestosterone Pharmacological target (+,+) : BE0000132 Androgen receptor --------------------------------------------------- Drug1 : DB01541 Boldenone Drug2 : DB08804 Nandrolone decanoate Pharmacological target (+,+) : BE0000132 Androgen receptor --------------------------------------------------- Drug1 : DB01548 Diprenorphine Drug2 : DB09049 Naloxegol Pharmacological target (-,-) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (-1) BE0000420 Delta-type opioid receptor (-1) --------------------------------------------------- Drug1 : DB01558 Bromazepam Drug2 : DB01559 Clotiazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Pharmacological target (+,+) : BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Pharmacological target (+,+) : BE0003596 Gamma-aminobutyric acid receptor subunit pi Pharmacological target (+,+) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Pharmacological target (+,+) : BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 Pharmacological target (+,+) : BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 Non-common off-target(s) (drug1) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB01558 Bromazepam Drug2 : DB01567 Fludiazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Pharmacological target (+,+) : BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Pharmacological target (+,+) : BE0003596 Gamma-aminobutyric acid receptor subunit pi Pharmacological target (+,+) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Pharmacological target (+,+) : BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 Pharmacological target (+,+) : BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 Non-common off-target(s) (drug1) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB01558 Bromazepam Drug2 : DB01588 Prazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Pharmacological target (+,+) : BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Pharmacological target (+,+) : BE0003596 Gamma-aminobutyric acid receptor subunit pi Pharmacological target (+,+) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Pharmacological target (+,+) : BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 Pharmacological target (+,+) : BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 Non-common off-target(s) (drug1) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) --------------------------------------------------- Drug1 : DB01558 Bromazepam Drug2 : DB01589 Quazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Pharmacological target (+,+) : BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Pharmacological target (+,+) : BE0003596 Gamma-aminobutyric acid receptor subunit pi Pharmacological target (+,+) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Pharmacological target (+,+) : BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 Pharmacological target (+,+) : BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 Non-common off-target(s) (drug1) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) --------------------------------------------------- Drug1 : DB01558 Bromazepam Drug2 : DB01594 Cinolazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Pharmacological target (+,+) : BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Pharmacological target (+,+) : BE0003596 Gamma-aminobutyric acid receptor subunit pi Pharmacological target (+,+) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Pharmacological target (+,+) : BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 Pharmacological target (+,+) : BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 Non-common off-target(s) (drug1) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB01558 Bromazepam Drug2 : DB01595 Nitrazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Pharmacological target (+,+) : BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Pharmacological target (+,+) : BE0003596 Gamma-aminobutyric acid receptor subunit pi Pharmacological target (+,+) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Pharmacological target (+,+) : BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 Pharmacological target (+,+) : BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 Pharmacological target (+,+) : BE0003597 Gamma-aminobutyric acid receptor subunit theta --------------------------------------------------- Drug1 : DB01559 Clotiazepam Drug2 : DB01567 Fludiazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Pharmacological target (+,+) : BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Pharmacological target (+,+) : BE0003596 Gamma-aminobutyric acid receptor subunit pi Pharmacological target (+,+) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Pharmacological target (+,+) : BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 Pharmacological target (+,+) : BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 --------------------------------------------------- Drug1 : DB01559 Clotiazepam Drug2 : DB01588 Prazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Pharmacological target (+,+) : BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Pharmacological target (+,+) : BE0003596 Gamma-aminobutyric acid receptor subunit pi Pharmacological target (+,+) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Pharmacological target (+,+) : BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 Pharmacological target (+,+) : BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) --------------------------------------------------- Drug1 : DB01559 Clotiazepam Drug2 : DB01589 Quazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Pharmacological target (+,+) : BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Pharmacological target (+,+) : BE0003596 Gamma-aminobutyric acid receptor subunit pi Pharmacological target (+,+) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Pharmacological target (+,+) : BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 Pharmacological target (+,+) : BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 Non-common off-target(s) (drug1) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) --------------------------------------------------- Drug1 : DB01559 Clotiazepam Drug2 : DB01594 Cinolazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Pharmacological target (+,+) : BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Pharmacological target (+,+) : BE0003596 Gamma-aminobutyric acid receptor subunit pi Pharmacological target (+,+) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Pharmacological target (+,+) : BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 Pharmacological target (+,+) : BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 --------------------------------------------------- Drug1 : DB01559 Clotiazepam Drug2 : DB01595 Nitrazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Pharmacological target (+,+) : BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Pharmacological target (+,+) : BE0003596 Gamma-aminobutyric acid receptor subunit pi Pharmacological target (+,+) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Pharmacological target (+,+) : BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 Pharmacological target (+,+) : BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 Non-common off-target(s) (drug2) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB01565 Dihydromorphine Drug2 : DB06204 Tapentadol Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) BE0000947 Pro-opiomelanocortin (1) BE0001063 E3 ubiquitin-protein ligase TRIM13 (1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB01567 Fludiazepam Drug2 : DB01588 Prazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Pharmacological target (+,+) : BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Pharmacological target (+,+) : BE0003596 Gamma-aminobutyric acid receptor subunit pi Pharmacological target (+,+) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Pharmacological target (+,+) : BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 Pharmacological target (+,+) : BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) --------------------------------------------------- Drug1 : DB01567 Fludiazepam Drug2 : DB01589 Quazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Pharmacological target (+,+) : BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Pharmacological target (+,+) : BE0003596 Gamma-aminobutyric acid receptor subunit pi Pharmacological target (+,+) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Pharmacological target (+,+) : BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 Pharmacological target (+,+) : BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 Non-common off-target(s) (drug1) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) Non-common off-target(s) (drug2) : BE0004797 GABA-A receptor (anion channel) (1) --------------------------------------------------- Drug1 : DB01567 Fludiazepam Drug2 : DB01594 Cinolazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Pharmacological target (+,+) : BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Pharmacological target (+,+) : BE0003596 Gamma-aminobutyric acid receptor subunit pi Pharmacological target (+,+) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Pharmacological target (+,+) : BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 Pharmacological target (+,+) : BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 --------------------------------------------------- Drug1 : DB01567 Fludiazepam Drug2 : DB01595 Nitrazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Pharmacological target (+,+) : BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Pharmacological target (+,+) : BE0003596 Gamma-aminobutyric acid receptor subunit pi Pharmacological target (+,+) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Pharmacological target (+,+) : BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 Pharmacological target (+,+) : BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 Non-common off-target(s) (drug2) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB01571 3-Methylfentanyl Drug2 : DB06738 Ketobemidone Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Pharmacological target (+,+) : BE0000632 Kappa-type opioid receptor Pharmacological target (+,+) : BE0000420 Delta-type opioid receptor Non-common off-target(s) (drug2) : BE0004956 NMDA receptor (-1) --------------------------------------------------- Drug1 : DB01576 Dextroamphetamine Drug2 : DB06701 Dexmethylphenidate Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000118 Synaptic vesicular amine transporter (1) BE0001044 Trace amine-associated receptor 1 (1) BE0000575 Alpha-1B adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) --------------------------------------------------- Drug1 : DB01579 Phendimetrazine Drug2 : DB04896 Milnacipran Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0004956 NMDA receptor (-1) --------------------------------------------------- Drug1 : DB01579 Phendimetrazine Drug2 : DB06204 Tapentadol Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000770 Mu-type opioid receptor (1) --------------------------------------------------- Drug1 : DB01579 Phendimetrazine Drug2 : DB06700 Desvenlafaxine Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) --------------------------------------------------- Drug1 : DB01579 Phendimetrazine Drug2 : DB06701 Dexmethylphenidate Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) --------------------------------------------------- Drug1 : DB01579 Phendimetrazine Drug2 : DB06706 Isometheptene Pharmacological target (+,+) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000575 Alpha-1B adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (-1) --------------------------------------------------- Drug1 : DB01579 Phendimetrazine Drug2 : DB06711 Naphazoline Pharmacological target (+,+) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000575 Alpha-1B adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01579 Phendimetrazine Drug2 : DB08918 Levomilnacipran Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) --------------------------------------------------- Drug1 : DB01588 Prazepam Drug2 : DB01589 Quazepam Pharmacological target (+,+) : BE0004797 GABA-A receptor (anion channel) Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Pharmacological target (+,+) : BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Pharmacological target (+,+) : BE0003596 Gamma-aminobutyric acid receptor subunit pi Pharmacological target (+,+) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Pharmacological target (+,+) : BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 Pharmacological target (+,+) : BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 Non-common off-target(s) (drug1) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) --------------------------------------------------- Drug1 : DB01588 Prazepam Drug2 : DB01594 Cinolazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Pharmacological target (+,+) : BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Pharmacological target (+,+) : BE0003596 Gamma-aminobutyric acid receptor subunit pi Pharmacological target (+,+) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Pharmacological target (+,+) : BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 Pharmacological target (+,+) : BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) --------------------------------------------------- Drug1 : DB01588 Prazepam Drug2 : DB01595 Nitrazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Pharmacological target (+,+) : BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Pharmacological target (+,+) : BE0003596 Gamma-aminobutyric acid receptor subunit pi Pharmacological target (+,+) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Pharmacological target (+,+) : BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 Pharmacological target (+,+) : BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) Non-common off-target(s) (drug2) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB01589 Quazepam Drug2 : DB01594 Cinolazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Pharmacological target (+,+) : BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Pharmacological target (+,+) : BE0003596 Gamma-aminobutyric acid receptor subunit pi Pharmacological target (+,+) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Pharmacological target (+,+) : BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 Pharmacological target (+,+) : BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) Non-common off-target(s) (drug2) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) --------------------------------------------------- Drug1 : DB01589 Quazepam Drug2 : DB01595 Nitrazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Pharmacological target (+,+) : BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Pharmacological target (+,+) : BE0003596 Gamma-aminobutyric acid receptor subunit pi Pharmacological target (+,+) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Pharmacological target (+,+) : BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 Pharmacological target (+,+) : BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 Non-common off-target(s) (drug1) : BE0004797 GABA-A receptor (anion channel) (1) Non-common off-target(s) (drug2) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB01590 Everolimus Drug2 : DB06287 Temsirolimus Pharmacological target (-,-) : BE0002386 Serine/threonine-protein kinase mTOR --------------------------------------------------- Drug1 : DB01594 Cinolazepam Drug2 : DB01595 Nitrazepam Pharmacological target (+,+) : BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 Pharmacological target (+,+) : BE0000381 Gamma-aminobutyric acid receptor subunit alpha-2 Pharmacological target (+,+) : BE0000523 Gamma-aminobutyric acid receptor subunit alpha-3 Pharmacological target (+,+) : BE0000471 Gamma-aminobutyric acid receptor subunit alpha-5 Pharmacological target (+,+) : BE0002344 Gamma-aminobutyric acid receptor subunit beta-1 Pharmacological target (+,+) : BE0002346 Gamma-aminobutyric acid receptor subunit beta-2 Pharmacological target (+,+) : BE0002345 Gamma-aminobutyric acid receptor subunit beta-3 Pharmacological target (+,+) : BE0003593 Gamma-aminobutyric acid receptor subunit gamma-1 Pharmacological target (+,+) : BE0003592 Gamma-aminobutyric acid receptor subunit gamma-2 Pharmacological target (+,+) : BE0003594 Gamma-aminobutyric acid receptor subunit gamma-3 Pharmacological target (+,+) : BE0003599 Gamma-aminobutyric acid receptor subunit delta Pharmacological target (+,+) : BE0003595 Gamma-aminobutyric acid receptor subunit epsilon Pharmacological target (+,+) : BE0003596 Gamma-aminobutyric acid receptor subunit pi Pharmacological target (+,+) : BE0000129 Gamma-aminobutyric acid receptor subunit rho-1 Pharmacological target (+,+) : BE0003598 Gamma-aminobutyric acid receptor subunit rho-2 Pharmacological target (+,+) : BE0003619 Gamma-aminobutyric acid receptor subunit rho-3 Non-common off-target(s) (drug2) : BE0000478 Gamma-aminobutyric acid receptor subunit alpha-4 (1) BE0000764 Gamma-aminobutyric acid receptor subunit alpha-6 (1) BE0003597 Gamma-aminobutyric acid receptor subunit theta (1) --------------------------------------------------- Drug1 : DB01600 Tiaprofenic acid Drug2 : DB01628 Etoricoxib Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) --------------------------------------------------- Drug1 : DB01600 Tiaprofenic acid Drug2 : DB04552 Niflumic Acid Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) Non-common off-target(s) (drug2) : BE0003997 Phospholipase A2 (-1) BE0002376 Chloride channel protein ClC-Ka (1) --------------------------------------------------- Drug1 : DB01600 Tiaprofenic acid Drug2 : DB04743 Nimesulide Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0000017 Prostaglandin G/H synthase 1 (-1) --------------------------------------------------- Drug1 : DB01600 Tiaprofenic acid Drug2 : DB06725 Lornoxicam Pharmacological target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 --------------------------------------------------- Drug1 : DB01612 Amyl Nitrite Drug2 : DB01613 Erythrityl Tetranitrate Pharmacological target (+,+) : BE0000556 Atrial natriuretic peptide receptor 1 Non-common off-target(s) (drug2) : BE0000997 Atrial natriuretic peptide receptor 2 (1) --------------------------------------------------- Drug1 : DB01614 Acepromazine Drug2 : DB01621 Pipotiazine Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Pharmacological target (-,-) : BE0000291 5-hydroxytryptamine receptor 1A Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Pharmacological target (-,-) : BE0000020 D(1A) dopamine receptor Non-common off-target(s) (drug1) : BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB01614 Acepromazine Drug2 : DB01623 Thiothixene Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Pharmacological target (-,-) : BE0000020 D(1A) dopamine receptor Non-common off-target(s) (drug1) : BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) --------------------------------------------------- Drug1 : DB01614 Acepromazine Drug2 : DB06144 Sertindole Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000020 D(1A) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) --------------------------------------------------- Drug1 : DB01615 Aceprometazine Drug2 : DB01619 Phenindamine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB01615 Aceprometazine Drug2 : DB01620 Pheniramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB01615 Aceprometazine Drug2 : DB04837 Clofedanol Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB01615 Aceprometazine Drug2 : DB04890 Bepotastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB01615 Aceprometazine Drug2 : DB06691 Mepyramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB01615 Aceprometazine Drug2 : DB08799 Antazoline Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB01615 Aceprometazine Drug2 : DB08800 Chloropyramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB01615 Aceprometazine Drug2 : DB08801 Dimetindene Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB01615 Aceprometazine Drug2 : DB08802 Isothipendyl Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB01615 Aceprometazine Drug2 : DB08936 Chlorcyclizine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB01618 Molindone Drug2 : DB09018 Bromopride Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) --------------------------------------------------- Drug1 : DB01619 Phenindamine Drug2 : DB01620 Pheniramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB01619 Phenindamine Drug2 : DB04837 Clofedanol Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB01619 Phenindamine Drug2 : DB04890 Bepotastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB01619 Phenindamine Drug2 : DB06691 Mepyramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB01619 Phenindamine Drug2 : DB08799 Antazoline Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB01619 Phenindamine Drug2 : DB08800 Chloropyramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB01619 Phenindamine Drug2 : DB08801 Dimetindene Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB01619 Phenindamine Drug2 : DB08802 Isothipendyl Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB01619 Phenindamine Drug2 : DB08936 Chlorcyclizine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB01620 Pheniramine Drug2 : DB04837 Clofedanol Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB01620 Pheniramine Drug2 : DB04890 Bepotastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB01620 Pheniramine Drug2 : DB06691 Mepyramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB01620 Pheniramine Drug2 : DB08799 Antazoline Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB01620 Pheniramine Drug2 : DB08800 Chloropyramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB01620 Pheniramine Drug2 : DB08801 Dimetindene Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB01620 Pheniramine Drug2 : DB08802 Isothipendyl Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB01620 Pheniramine Drug2 : DB08936 Chlorcyclizine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB01621 Pipotiazine Drug2 : DB01623 Thiothixene Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Pharmacological target (-,-) : BE0000020 D(1A) dopamine receptor Non-common off-target(s) (drug1) : BE0000291 5-hydroxytryptamine receptor 1A (-1) --------------------------------------------------- Drug1 : DB01621 Pipotiazine Drug2 : DB06144 Sertindole Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000020 D(1A) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) --------------------------------------------------- Drug1 : DB01623 Thiothixene Drug2 : DB06144 Sertindole Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000020 D(1A) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) --------------------------------------------------- Drug1 : DB01623 Thiothixene Drug2 : DB08815 Lurasidone Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000020 D(1A) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000342 Alpha-2C adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB01625 Isopropamide Drug2 : DB04843 Mepenzolate Pharmacological target (-,-) : BE0000045 Muscarinic acetylcholine receptor M3 Non-common off-target(s) (drug1) : BE0000405 Muscarinic acetylcholine receptor M4 (-1) Non-common off-target(s) (drug2) : BE0000092 Muscarinic acetylcholine receptor M1 (-1) --------------------------------------------------- Drug1 : DB01628 Etoricoxib Drug2 : DB04552 Niflumic Acid Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug2) : BE0003997 Phospholipase A2 (-1) BE0002376 Chloride channel protein ClC-Ka (1) --------------------------------------------------- Drug1 : DB01628 Etoricoxib Drug2 : DB04743 Nimesulide Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 --------------------------------------------------- Drug1 : DB01628 Etoricoxib Drug2 : DB06725 Lornoxicam Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug2) : BE0000017 Prostaglandin G/H synthase 1 (-1) --------------------------------------------------- Drug1 : DB04552 Niflumic Acid Drug2 : DB04743 Nimesulide Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0003997 Phospholipase A2 (-1) BE0002376 Chloride channel protein ClC-Ka (1) --------------------------------------------------- Drug1 : DB04552 Niflumic Acid Drug2 : DB06725 Lornoxicam Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug1) : BE0003997 Phospholipase A2 (-1) BE0002376 Chloride channel protein ClC-Ka (1) Non-common off-target(s) (drug2) : BE0000017 Prostaglandin G/H synthase 1 (-1) --------------------------------------------------- Drug1 : DB04573 Estriol Drug2 : DB04575 Quinestrol Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug1) : BE0000792 Estrogen receptor beta (1) --------------------------------------------------- Drug1 : DB04574 Estropipate Drug2 : DB04575 Quinestrol Pharmacological target (+,+) : BE0000123 Estrogen receptor Non-common off-target(s) (drug1) : BE0000792 Estrogen receptor beta (1) --------------------------------------------------- Drug1 : DB04576 Fleroxacin Drug2 : DB09047 Finafloxacin Pharmacological target (-,-) : BE0000742 DNA topoisomerase 2-alpha --------------------------------------------------- Drug1 : DB04743 Nimesulide Drug2 : DB06725 Lornoxicam Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Non-common off-target(s) (drug2) : BE0000017 Prostaglandin G/H synthase 1 (-1) --------------------------------------------------- Drug1 : DB04837 Clofedanol Drug2 : DB04890 Bepotastine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB04837 Clofedanol Drug2 : DB06691 Mepyramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB04837 Clofedanol Drug2 : DB08799 Antazoline Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB04837 Clofedanol Drug2 : DB08800 Chloropyramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB04837 Clofedanol Drug2 : DB08801 Dimetindene Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB04837 Clofedanol Drug2 : DB08802 Isothipendyl Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB04837 Clofedanol Drug2 : DB08936 Chlorcyclizine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB04839 Cyproterone acetate Drug2 : DB08899 Enzalutamide Pharmacological target (-,-) : BE0000132 Androgen receptor --------------------------------------------------- Drug1 : DB04842 Fluspirilene Drug2 : DB09018 Bromopride Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000679 Voltage-dependent calcium channel gamma-1 subunit (-1) --------------------------------------------------- Drug1 : DB04844 Tetrabenazine Drug2 : DB06706 Isometheptene Pharmacological target (-,-) : BE0000118 Synaptic vesicular amine transporter Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB04868 Nilotinib Drug2 : DB06616 Bosutinib Pharmacological target (-,-) : BE0000014 Tyrosine-protein kinase ABL1 Non-common off-target(s) (drug1) : BE0000453 Mast/stem cell growth factor receptor Kit (-1) Non-common off-target(s) (drug2) : BE0000838 Proto-oncogene tyrosine-protein kinase Src (-1) BE0001072 Cyclin-dependent kinase 2 (-1) BE0001424 Tyrosine-protein kinase HCK (-1) BE0000870 Dual specificity mitogen-activated protein kinase kinase 1 (-1) BE0004743 Breakpoint cluster region protein (-1) BE0004744 Dual specificity mitogen-activated protein kinase kinase 2 (-1) BE0004745 Mitogen-activated protein kinase kinase kinase 2 (-1) BE0004384 Calcium/calmodulin-dependent protein kinase type II subunit gamma (-1) --------------------------------------------------- Drug1 : DB04876 Vildagliptin Drug2 : DB06203 Alogliptin Pharmacological target (-,-) : BE0000854 Dipeptidyl peptidase 4 --------------------------------------------------- Drug1 : DB04876 Vildagliptin Drug2 : DB06335 Saxagliptin Pharmacological target (-,-) : BE0000854 Dipeptidyl peptidase 4 --------------------------------------------------- Drug1 : DB04876 Vildagliptin Drug2 : DB08882 Linagliptin Pharmacological target (-,-) : BE0000854 Dipeptidyl peptidase 4 --------------------------------------------------- Drug1 : DB04890 Bepotastine Drug2 : DB06691 Mepyramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB04890 Bepotastine Drug2 : DB08799 Antazoline Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB04890 Bepotastine Drug2 : DB08800 Chloropyramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB04890 Bepotastine Drug2 : DB08801 Dimetindene Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB04890 Bepotastine Drug2 : DB08802 Isothipendyl Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB04890 Bepotastine Drug2 : DB08936 Chlorcyclizine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB04896 Milnacipran Drug2 : DB06700 Desvenlafaxine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0004956 NMDA receptor (-1) --------------------------------------------------- Drug1 : DB04896 Milnacipran Drug2 : DB08918 Levomilnacipran Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0004956 NMDA receptor (-1) --------------------------------------------------- Drug1 : DB04898 Ximelagatran Drug2 : DB06695 Dabigatran etexilate Pharmacological target (-,-) : BE0000048 Prothrombin --------------------------------------------------- Drug1 : DB04946 Iloperidone Drug2 : DB09018 Bromopride Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000501 Alpha-1A adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) BE0000342 Alpha-2C adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB04948 Lofexidine Drug2 : DB06711 Naphazoline Pharmacological target (+,+) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB05039 Indacaterol Drug2 : DB09080 Olodaterol Pharmacological target (+,+) : BE0000694 Beta-2 adrenergic receptor --------------------------------------------------- Drug1 : DB06073 CTS-21166 Drug2 : DB08929 MK-8931 Pharmacological target (-,-) : BE0000988 Beta-secretase 1 --------------------------------------------------- Drug1 : DB06144 Sertindole Drug2 : DB08815 Lurasidone Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000090 Potassium voltage-gated channel subfamily H member 2 (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) Non-common off-target(s) (drug2) : BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000342 Alpha-2C adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB06203 Alogliptin Drug2 : DB06335 Saxagliptin Pharmacological target (-,-) : BE0000854 Dipeptidyl peptidase 4 --------------------------------------------------- Drug1 : DB06203 Alogliptin Drug2 : DB08882 Linagliptin Pharmacological target (-,-) : BE0000854 Dipeptidyl peptidase 4 --------------------------------------------------- Drug1 : DB06209 Prasugrel Drug2 : DB08816 Ticagrelor Pharmacological target (-,-) : BE0000110 P2Y purinoceptor 12 --------------------------------------------------- Drug1 : DB06216 Asenapine Drug2 : DB09018 Bromopride Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000172 Beta-1 adrenergic receptor (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000694 Beta-2 adrenergic receptor (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000797 5-hydroxytryptamine receptor 1B (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000112 Histamine H2 receptor (-1) BE0004688 5-hydroxytryptamine receptor 5A (-1) --------------------------------------------------- Drug1 : DB06228 Rivaroxaban Drug2 : DB06605 Apixaban Pharmacological target (-,-) : BE0000216 Coagulation factor X --------------------------------------------------- Drug1 : DB06228 Rivaroxaban Drug2 : DB09075 Edoxaban Pharmacological target (-,-) : BE0000216 Coagulation factor X --------------------------------------------------- Drug1 : DB06237 Avanafil Drug2 : DB06267 Udenafil Pharmacological target (-,-) : BE0000182 cGMP-specific 3',5'-cyclic phosphodiesterase --------------------------------------------------- Drug1 : DB06271 Sulodexide Drug2 : DB06822 Tinzaparin Pharmacological target (+,+) : BE0000280 Antithrombin-III Non-common off-target(s) (drug1) : BE0000775 Heparin cofactor 2 (1) Non-common off-target(s) (drug2) : BE0000590 Integrin alpha-4 (-1) --------------------------------------------------- Drug1 : DB06271 Sulodexide Drug2 : DB08813 Nadroparin Pharmacological target (+,+) : BE0000280 Antithrombin-III Non-common off-target(s) (drug1) : BE0000775 Heparin cofactor 2 (1) Non-common off-target(s) (drug2) : BE0001159 P-selectin (-1) BE0001126 Proto-oncogene c-Fos (-1) BE0004689 Myc proto-oncogene protein (-1) --------------------------------------------------- Drug1 : DB06274 Alvimopan Drug2 : DB09049 Naloxegol Pharmacological target (-,-) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (-1) BE0000420 Delta-type opioid receptor (-1) --------------------------------------------------- Drug1 : DB06288 Amisulpride Drug2 : DB09018 Bromopride Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000581 D(3) dopamine receptor (-1) --------------------------------------------------- Drug1 : DB06292 Dapagliflozin Drug2 : DB08907 Canagliflozin Pharmacological target (-,-) : BE0004753 Sodium/glucose cotransporter 2 Non-common off-target(s) (drug2) : BE0004754 Sodium/glucose cotransporter 1 (-1) --------------------------------------------------- Drug1 : DB06335 Saxagliptin Drug2 : DB08882 Linagliptin Pharmacological target (-,-) : BE0000854 Dipeptidyl peptidase 4 --------------------------------------------------- Drug1 : DB06594 Agomelatine Drug2 : DB09071 Tasimelteon Pharmacological target (+,+) : BE0000515 Melatonin receptor type 1A Pharmacological target (+,+) : BE0000327 Melatonin receptor type 1B Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (-1) --------------------------------------------------- Drug1 : DB06605 Apixaban Drug2 : DB09075 Edoxaban Pharmacological target (-,-) : BE0000216 Coagulation factor X --------------------------------------------------- Drug1 : DB06655 Liraglutide Drug2 : DB09043 Albiglutide Pharmacological target (+,+) : BE0000857 Glucagon-like peptide 1 receptor --------------------------------------------------- Drug1 : DB06655 Liraglutide Drug2 : DB09045 Dulaglutide Pharmacological target (+,+) : BE0000857 Glucagon-like peptide 1 receptor --------------------------------------------------- Drug1 : DB06691 Mepyramine Drug2 : DB08799 Antazoline Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB06691 Mepyramine Drug2 : DB08800 Chloropyramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB06691 Mepyramine Drug2 : DB08801 Dimetindene Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB06691 Mepyramine Drug2 : DB08802 Isothipendyl Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB06691 Mepyramine Drug2 : DB08936 Chlorcyclizine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB06693 Mevastatin Drug2 : DB08860 Pitavastatin Pharmacological target (-,-) : BE0000574 3-hydroxy-3-methylglutaryl-coenzyme A reductase --------------------------------------------------- Drug1 : DB06694 Xylometazoline Drug2 : DB06711 Naphazoline Pharmacological target (+,+) : BE0000501 Alpha-1A adrenergic receptor Pharmacological target (+,+) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB06700 Desvenlafaxine Drug2 : DB08918 Levomilnacipran Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter --------------------------------------------------- Drug1 : DB06706 Isometheptene Drug2 : DB06707 Levonordefrin Pharmacological target (+,+) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000118 Synaptic vesicular amine transporter (-1) Non-common off-target(s) (drug2) : BE0000486 Sodium-dependent noradrenaline transporter (-1) --------------------------------------------------- Drug1 : DB06706 Isometheptene Drug2 : DB06711 Naphazoline Pharmacological target (+,+) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000118 Synaptic vesicular amine transporter (-1) Non-common off-target(s) (drug2) : BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB06707 Levonordefrin Drug2 : DB06711 Naphazoline Pharmacological target (+,+) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000486 Sodium-dependent noradrenaline transporter (-1) Non-common off-target(s) (drug2) : BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB06710 Methyltestosterone Drug2 : DB08804 Nandrolone decanoate Pharmacological target (+,+) : BE0000132 Androgen receptor --------------------------------------------------- Drug1 : DB06733 Bafilomycin A1 Drug2 : DB06734 Bafilomycin B1 Pharmacological target (-,-) : BE0003569 V-type proton ATPase catalytic subunit A --------------------------------------------------- Drug1 : DB06781 Difluprednate Drug2 : DB08906 Fluticasone furoate Pharmacological target (+,+) : BE0000794 Glucocorticoid receptor --------------------------------------------------- Drug1 : DB06800 Methylnaltrexone Drug2 : DB09049 Naloxegol Pharmacological target (-,-) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000632 Kappa-type opioid receptor (-1) --------------------------------------------------- Drug1 : DB06822 Tinzaparin Drug2 : DB08813 Nadroparin Pharmacological target (+,+) : BE0000280 Antithrombin-III Non-common off-target(s) (drug1) : BE0000590 Integrin alpha-4 (-1) Non-common off-target(s) (drug2) : BE0001159 P-selectin (-1) BE0001126 Proto-oncogene c-Fos (-1) BE0004689 Myc proto-oncogene protein (-1) --------------------------------------------------- Drug1 : DB08799 Antazoline Drug2 : DB08800 Chloropyramine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB08799 Antazoline Drug2 : DB08801 Dimetindene Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB08799 Antazoline Drug2 : DB08802 Isothipendyl Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB08799 Antazoline Drug2 : DB08936 Chlorcyclizine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB08800 Chloropyramine Drug2 : DB08801 Dimetindene Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug2) : BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB08800 Chloropyramine Drug2 : DB08802 Isothipendyl Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB08800 Chloropyramine Drug2 : DB08936 Chlorcyclizine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB08801 Dimetindene Drug2 : DB08802 Isothipendyl Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB08801 Dimetindene Drug2 : DB08936 Chlorcyclizine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000560 Muscarinic acetylcholine receptor M2 (-1) --------------------------------------------------- Drug1 : DB08801 Dimetindene Drug2 : DB09076 Umeclidinium Pharmacological target (-,-) : BE0000560 Muscarinic acetylcholine receptor M2 Non-common off-target(s) (drug1) : BE0000442 Histamine H1 receptor (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB08802 Isothipendyl Drug2 : DB08936 Chlorcyclizine Pharmacological target (-,-) : BE0000442 Histamine H1 receptor --------------------------------------------------- Drug1 : DB08805 Metiamide Drug2 : DB08806 Roxatidine acetate Pharmacological target (-,-) : BE0000112 Histamine H2 receptor --------------------------------------------------- Drug1 : DB08815 Lurasidone Drug2 : DB09018 Bromopride Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Non-common off-target(s) (drug1) : BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000342 Alpha-2C adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB08865 Crizotinib Drug2 : DB09063 Ceritinib Pharmacological target (-,-) : BE0000359 ALK tyrosine kinase receptor Non-common off-target(s) (drug1) : BE0000915 Hepatocyte growth factor receptor (-1) --------------------------------------------------- Drug1 : DB08877 Ruxolitinib Drug2 : DB08895 Tofacitinib Pharmacological target (-,-) : BE0002408 Tyrosine-protein kinase JAK2 Pharmacological target (-,-) : BE0004145 Tyrosine-protein kinase JAK1 Non-common off-target(s) (drug2) : BE0003493 Tyrosine-protein kinase JAK3 (-1) --------------------------------------------------- Drug1 : DB08881 Vemurafenib Drug2 : DB08912 Dabrafenib Pharmacological target (-,-) : BE0000634 Serine/threonine-protein kinase B-raf Non-common off-target(s) (drug2) : BE0000036 RAF proto-oncogene serine/threonine-protein kinase (-1) BE0004757 Serine/threonine-protein kinase SIK1 (-1) BE0004758 Serine/threonine-protein kinase Nek11 (-1) BE0004759 LIM domain kinase 1 (-1) --------------------------------------------------- Drug1 : DB08891 Arbaclofen Drug2 : DB08892 Arbaclofen Placarbil Pharmacological target (+,+) : BE0000217 Gamma-aminobutyric acid type B receptor subunit 1 Pharmacological target (+,+) : BE0002340 Gamma-aminobutyric acid type B receptor subunit 2 --------------------------------------------------- Drug1 : DB08894 Peginesatide Drug2 : DB08923 Epoetin Zeta Pharmacological target (+,+) : BE0000654 Erythropoietin receptor --------------------------------------------------- Drug1 : DB09043 Albiglutide Drug2 : DB09045 Dulaglutide Pharmacological target (+,+) : BE0000857 Glucagon-like peptide 1 receptor --------------------------------------------------- Drug1 : DB09078 Lenvatinib Drug2 : DB09079 Nintedanib Pharmacological target (-,-) : BE0000748 Fibroblast growth factor receptor 2 Pharmacological target (-,-) : BE0002131 Fibroblast growth factor receptor 1 Pharmacological target (-,-) : BE0002133 Fibroblast growth factor receptor 3 Pharmacological target (-,-) : BE0000023 Vascular endothelial growth factor receptor 3 Pharmacological target (-,-) : BE0000369 Vascular endothelial growth factor receptor 2 Pharmacological target (-,-) : BE0000029 Vascular endothelial growth factor receptor 1 Pharmacological target (-,-) : BE0008625 Platelet derived growth factor receptor alpha Non-common off-target(s) (drug1) : BE0001203 Fibroblast growth factor receptor 4 (-1) BE0000453 Mast/stem cell growth factor receptor Kit (-1) BE0008626 RET (-1) Non-common off-target(s) (drug2) : BE0000147 Receptor-type tyrosine-protein kinase FLT3 (-1) BE0000838 Proto-oncogene tyrosine-protein kinase Src (-1) BE0000842 Tyrosine-protein kinase Lck (-1) BE0004315 Tyrosine-protein kinase Lyn (-1) BE0008628 Platelet derived growth factor receptor beta (-1) ---------------------------------------------------