Drug pairs with common pharmacological targets that do not change the overall side effect on the 2 drugs Drug1 : DB00159 Icosapent Drug2 : DB00605 Sulindac Pharmacological target (-,-) : BE0000262 Prostaglandin G/H synthase 2 Common off-target (-,-) : BE0000017 Prostaglandin G/H synthase 1 Common off-target (+,-) : BE0001007 Peroxisome proliferator-activated receptor delta Non-common off-target(s) (drug1) : BE0000888 Fatty acid desaturase 1 (1) BE0000986 Sodium/calcium exchanger 1 (-1) BE0001023 Transient receptor potential cation channel subfamily V member 1 (1) BE0000215 Peroxisome proliferator-activated receptor gamma (1) BE0000996 Long-chain-fatty-acid--CoA ligase 4 (1) BE0001093 Long-chain-fatty-acid--CoA ligase 3 (1) BE0000688 Free fatty acid receptor 1 (1) Non-common off-target(s) (drug2) : BE0000747 Aldose reductase (-1) BE0003561 Prostaglandin D2 receptor 2 (-1) BE0001062 Mitogen-activated protein kinase 3 (-1) --------------------------------------------------- Drug1 : DB00182 Amphetamine Drug2 : DB01454 3,4-Methylenedioxymethamphetamine Pharmacological target (-,-) : BE0000118 Synaptic vesicular amine transporter Common off-target (-,-) : BE0000647 Sodium-dependent dopamine transporter Common off-target (+,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000867 Cocaine- and amphetamine-regulated transcript protein (1) BE0001044 Trace amine-associated receptor 1 (1) BE0004888 Alpha adrenergic receptor (1) BE0004872 Beta adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000533 5-hydroxytryptamine receptor 2C (1) BE0000393 5-hydroxytryptamine receptor 2B (1) BE0000451 5-hydroxytryptamine receptor 2A (1) --------------------------------------------------- Drug1 : DB00182 Amphetamine Drug2 : DB01576 Dextroamphetamine Pharmacological target (-,-) : BE0000647 Sodium-dependent dopamine transporter Pharmacological target (+,-) : BE0000118 Synaptic vesicular amine transporter Common off-target (+,+) : BE0001044 Trace amine-associated receptor 1 Common off-target (+,-) : BE0000486 Sodium-dependent noradrenaline transporter Non-common off-target(s) (drug1) : BE0000867 Cocaine- and amphetamine-regulated transcript protein (1) BE0004888 Alpha adrenergic receptor (1) BE0004872 Beta adrenergic receptor (1) Non-common off-target(s) (drug2) : BE0000575 Alpha-1B adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00193 Tramadol Drug2 : DB00647 Dextropropoxyphene Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Common off-target (+,+) : BE0000420 Delta-type opioid receptor Common off-target (+,-) : BE0000632 Kappa-type opioid receptor Non-common off-target(s) (drug1) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0003438 Alpha-7 nicotinic cholinergic receptor subunit (-1) --------------------------------------------------- Drug1 : DB00247 Methysergide Drug2 : DB00321 Amitriptyline Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Common off-target (-,-) : BE0000650 5-hydroxytryptamine receptor 7 Common off-target (+,-) : BE0000291 5-hydroxytryptamine receptor 1A Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000781 Potassium voltage-gated channel subfamily A member 1 (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000112 Histamine H2 receptor (-1) BE0003603 Potassium voltage-gated channel subfamily D member 2 (-1) BE0003604 Potassium voltage-gated channel subfamily D member 3 (-1) BE0001039 High affinity nerve growth factor receptor (1) BE0003605 BDNF/NT-3 growth factors receptor (1) BE0000897 Potassium voltage-gated channel subfamily KQT member 2 (-1) BE0000156 Sigma non-opioid intracellular receptor 1 (1) --------------------------------------------------- Drug1 : DB00247 Methysergide Drug2 : DB00540 Nortriptyline Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Common off-target (-,-) : BE0000533 5-hydroxytryptamine receptor 2C Common off-target (+,-) : BE0000291 5-hydroxytryptamine receptor 1A Non-common off-target(s) (drug1) : BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) Non-common off-target(s) (drug2) : BE0000749 Sodium-dependent serotonin transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0004872 Beta adrenergic receptor (-1) BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0004864 Alpha-2 adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00247 Methysergide Drug2 : DB00734 Risperidone Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Common off-target (-,-) : BE0000533 5-hydroxytryptamine receptor 2C Common off-target (+,-) : BE0000291 5-hydroxytryptamine receptor 1A Non-common off-target(s) (drug1) : BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000659 5-hydroxytryptamine receptor 1D (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00247 Methysergide Drug2 : DB04946 Iloperidone Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Common off-target (-,-) : BE0000650 5-hydroxytryptamine receptor 7 Common off-target (+,-) : BE0000291 5-hydroxytryptamine receptor 1A Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) BE0000342 Alpha-2C adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00247 Methysergide Drug2 : DB08815 Lurasidone Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Common off-target (-,-) : BE0000650 5-hydroxytryptamine receptor 7 Common off-target (+,-) : BE0000291 5-hydroxytryptamine receptor 1A Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00321 Amitriptyline Drug2 : DB00805 Minaprine Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Common off-target (-,-) : BE0000749 Sodium-dependent serotonin transporter Common off-target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000632 Kappa-type opioid receptor (1) BE0000420 Delta-type opioid receptor (1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000781 Potassium voltage-gated channel subfamily A member 1 (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0000112 Histamine H2 receptor (-1) BE0003603 Potassium voltage-gated channel subfamily D member 2 (-1) BE0003604 Potassium voltage-gated channel subfamily D member 3 (-1) BE0001039 High affinity nerve growth factor receptor (1) BE0003605 BDNF/NT-3 growth factors receptor (1) BE0000897 Potassium voltage-gated channel subfamily KQT member 2 (-1) BE0000156 Sigma non-opioid intracellular receptor 1 (1) Non-common off-target(s) (drug2) : BE0000426 Acetylcholinesterase (-1) BE0000756 D(2) dopamine receptor (1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000020 D(1A) dopamine receptor (1) --------------------------------------------------- Drug1 : DB00334 Olanzapine Drug2 : DB00805 Minaprine Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Common off-target (-,-) : BE0000533 5-hydroxytryptamine receptor 2C Common off-target (-,-) : BE0000393 5-hydroxytryptamine receptor 2B Common off-target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Common off-target (+,-) : BE0000020 D(1A) dopamine receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000659 5-hydroxytryptamine receptor 1D (-1) BE0000797 5-hydroxytryptamine receptor 1B (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000476 5-hydroxytryptamine receptor 1E (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000145 D(1B) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0004889 D(1) dopamine receptor (-1) BE0000112 Histamine H2 receptor (-1) BE0000146 Histamine H4 receptor (-1) BE0004688 5-hydroxytryptamine receptor 5A (-1) Non-common off-target(s) (drug2) : BE0000426 Acetylcholinesterase (-1) BE0000749 Sodium-dependent serotonin transporter (-1) BE0000756 D(2) dopamine receptor (1) BE0002198 Amine oxidase [flavin-containing] A (-1) --------------------------------------------------- Drug1 : DB00413 Pramipexole Drug2 : DB01200 Bromocriptine Pharmacological target (+,+) : BE0000756 D(2) dopamine receptor Pharmacological target (+,+) : BE0000581 D(3) dopamine receptor Common off-target (+,+) : BE0000289 Alpha-2A adrenergic receptor Common off-target (+,-) : BE0000389 D(4) dopamine receptor Non-common off-target(s) (drug2) : BE0000533 5-hydroxytryptamine receptor 2C (1) BE0000501 Alpha-1A adrenergic receptor (1) BE0000575 Alpha-1B adrenergic receptor (1) BE0000715 Alpha-1D adrenergic receptor (1) BE0000659 5-hydroxytryptamine receptor 1D (1) BE0000797 5-hydroxytryptamine receptor 1B (1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000393 5-hydroxytryptamine receptor 2B (1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000451 5-hydroxytryptamine receptor 2A (1) BE0000020 D(1A) dopamine receptor (1) BE0000145 D(1B) dopamine receptor (1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00514 Dextromethorphan Drug2 : DB00652 Pentazocine Pharmacological target (+,+) : BE0000156 Sigma non-opioid intracellular receptor 1 Common off-target (+,+) : BE0000632 Kappa-type opioid receptor Common off-target (+,-) : BE0000770 Mu-type opioid receptor Non-common off-target(s) (drug1) : BE0000641 Glutamate receptor ionotropic, NMDA 3A (-1) BE0000749 Sodium-dependent serotonin transporter (-1) BE0000849 Neuronal acetylcholine receptor subunit alpha-4 (-1) BE0002341 Neuronal acetylcholine receptor subunit alpha-7 (-1) BE0000850 Neuronal acetylcholine receptor subunit beta-2 (-1) BE0000738 Neuronal acetylcholine receptor subunit alpha-2 (-1) BE0003585 Neuronal acetylcholine receptor subunit alpha-3 (-1) BE0003584 Neuronal acetylcholine receptor subunit beta-4 (-1) BE0000420 Delta-type opioid receptor (1) BE0000290 HCG20471, isoform CRA_c (1) BE0004904 NADPH oxidase (-1) --------------------------------------------------- Drug1 : DB00540 Nortriptyline Drug2 : DB00656 Trazodone Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Common off-target (-,-) : BE0000501 Alpha-1A adrenergic receptor Common off-target (-,-) : BE0000442 Histamine H1 receptor Common off-target (+,-) : BE0000533 5-hydroxytryptamine receptor 2C Common off-target (+,-) : BE0000291 5-hydroxytryptamine receptor 1A Non-common off-target(s) (drug1) : BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0004872 Beta adrenergic receptor (-1) BE0000756 D(2) dopamine receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0004864 Alpha-2 adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) Non-common off-target(s) (drug2) : BE0000289 Alpha-2A adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00540 Nortriptyline Drug2 : DB00805 Minaprine Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Common off-target (-,-) : BE0000749 Sodium-dependent serotonin transporter Common off-target (-,-) : BE0000533 5-hydroxytryptamine receptor 2C Common off-target (+,-) : BE0000756 D(2) dopamine receptor Common off-target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0004872 Beta adrenergic receptor (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000715 Alpha-1D adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0004864 Alpha-2 adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) Non-common off-target(s) (drug2) : BE0000426 Acetylcholinesterase (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000020 D(1A) dopamine receptor (1) --------------------------------------------------- Drug1 : DB00543 Amoxapine Drug2 : DB01363 Ephedra Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Common off-target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Common off-target (+,-) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000797 5-hydroxytryptamine receptor 1B (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0004864 Alpha-2 adrenergic receptor (-1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) BE0004863 Alpha-1 adrenergic receptor (-1) BE0004890 Muscarinic acetylcholine receptor (-1) Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000694 Beta-2 adrenergic receptor (1) BE0004674 Chromaffin granule amine transporter (-1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00543 Amoxapine Drug2 : DB01442 MMDA Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Common off-target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Common off-target (+,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000797 5-hydroxytryptamine receptor 1B (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0004864 Alpha-2 adrenergic receptor (-1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0004863 Alpha-1 adrenergic receptor (-1) BE0004890 Muscarinic acetylcholine receptor (-1) Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) --------------------------------------------------- Drug1 : DB00543 Amoxapine Drug2 : DB01577 Methamphetamine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Common off-target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Common off-target (+,-) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0000756 D(2) dopamine receptor (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000797 5-hydroxytryptamine receptor 1B (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0004864 Alpha-2 adrenergic receptor (-1) BE0000795 Gamma-aminobutyric acid receptor subunit alpha-1 (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) BE0004863 Alpha-1 adrenergic receptor (-1) BE0004890 Muscarinic acetylcholine receptor (-1) Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0001044 Trace amine-associated receptor 1 (1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00647 Dextropropoxyphene Drug2 : DB00854 Levorphanol Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Common off-target (+,+) : BE0000420 Delta-type opioid receptor Common off-target (+,-) : BE0000632 Kappa-type opioid receptor --------------------------------------------------- Drug1 : DB00647 Dextropropoxyphene Drug2 : DB00899 Remifentanil Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Common off-target (+,+) : BE0000420 Delta-type opioid receptor Common off-target (+,-) : BE0000632 Kappa-type opioid receptor --------------------------------------------------- Drug1 : DB00647 Dextropropoxyphene Drug2 : DB01452 Heroin Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Common off-target (+,+) : BE0000420 Delta-type opioid receptor Common off-target (+,-) : BE0000632 Kappa-type opioid receptor --------------------------------------------------- Drug1 : DB00647 Dextropropoxyphene Drug2 : DB01565 Dihydromorphine Pharmacological target (+,+) : BE0000770 Mu-type opioid receptor Common off-target (+,+) : BE0000420 Delta-type opioid receptor Common off-target (+,-) : BE0000632 Kappa-type opioid receptor Non-common off-target(s) (drug2) : BE0000947 Pro-opiomelanocortin (1) BE0001063 E3 ubiquitin-protein ligase TRIM13 (1) --------------------------------------------------- Drug1 : DB00656 Trazodone Drug2 : DB00726 Trimipramine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Common off-target (-,-) : BE0000501 Alpha-1A adrenergic receptor Common off-target (-,-) : BE0000442 Histamine H1 receptor Common off-target (-,-) : BE0000289 Alpha-2A adrenergic receptor Common off-target (+,-) : BE0000533 5-hydroxytryptamine receptor 2C Common off-target (+,-) : BE0000291 5-hydroxytryptamine receptor 1A Common off-target (+,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug2) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000575 Alpha-1B adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00656 Trazodone Drug2 : DB01267 Paliperidone Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Pharmacological target (+,-) : BE0000533 5-hydroxytryptamine receptor 2C Common off-target (-,-) : BE0000501 Alpha-1A adrenergic receptor Common off-target (-,-) : BE0000289 Alpha-2A adrenergic receptor Common off-target (+,-) : BE0000442 Histamine H1 receptor Common off-target (+,-) : BE0000291 5-hydroxytryptamine receptor 1A Non-common off-target(s) (drug1) : BE0000749 Sodium-dependent serotonin transporter (-1) Non-common off-target(s) (drug2) : BE0000756 D(2) dopamine receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000659 5-hydroxytryptamine receptor 1D (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00656 Trazodone Drug2 : DB01454 3,4-Methylenedioxymethamphetamine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Common off-target (+,+) : BE0000533 5-hydroxytryptamine receptor 2C Common off-target (+,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000501 Alpha-1A adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (1) BE0000289 Alpha-2A adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (-1) BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000393 5-hydroxytryptamine receptor 2B (1) --------------------------------------------------- Drug1 : DB00726 Trimipramine Drug2 : DB01151 Desipramine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Common off-target (-,-) : BE0000442 Histamine H1 receptor Common off-target (+,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000694 Beta-2 adrenergic receptor (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0004863 Alpha-1 adrenergic receptor (-1) BE0000973 Sphingomyelin phosphodiesterase (-1) --------------------------------------------------- Drug1 : DB00726 Trimipramine Drug2 : DB01363 Ephedra Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Common off-target (-,-) : BE0000647 Sodium-dependent dopamine transporter Common off-target (+,-) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (1) Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000694 Beta-2 adrenergic receptor (1) BE0004674 Chromaffin granule amine transporter (-1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00726 Trimipramine Drug2 : DB01577 Methamphetamine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Common off-target (-,-) : BE0000647 Sodium-dependent dopamine transporter Common off-target (+,-) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (1) Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (-1) BE0001044 Trace amine-associated receptor 1 (1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB00726 Trimipramine Drug2 : DB09016 Butriptyline Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Common off-target (-,-) : BE0000442 Histamine H1 receptor Common off-target (+,-) : BE0000451 5-hydroxytryptamine receptor 2A Non-common off-target(s) (drug1) : BE0000647 Sodium-dependent dopamine transporter (-1) BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000289 Alpha-2A adrenergic receptor (-1) --------------------------------------------------- Drug1 : DB00734 Risperidone Drug2 : DB08815 Lurasidone Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Common off-target (-,-) : BE0000291 5-hydroxytryptamine receptor 1A Common off-target (+,-) : BE0000342 Alpha-2C adrenergic receptor Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000659 5-hydroxytryptamine receptor 1D (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000289 Alpha-2A adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000650 5-hydroxytryptamine receptor 7 (-1) --------------------------------------------------- Drug1 : DB00805 Minaprine Drug2 : DB01151 Desipramine Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Common off-target (-,-) : BE0000749 Sodium-dependent serotonin transporter Common off-target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000426 Acetylcholinesterase (-1) BE0000756 D(2) dopamine receptor (1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000020 D(1A) dopamine receptor (1) Non-common off-target(s) (drug2) : BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000694 Beta-2 adrenergic receptor (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000442 Histamine H1 receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) BE0004863 Alpha-1 adrenergic receptor (-1) BE0000973 Sphingomyelin phosphodiesterase (-1) --------------------------------------------------- Drug1 : DB00805 Minaprine Drug2 : DB01238 Aripiprazole Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Common off-target (-,-) : BE0000533 5-hydroxytryptamine receptor 2C Common off-target (+,-) : BE0000092 Muscarinic acetylcholine receptor M1 Non-common off-target(s) (drug1) : BE0000426 Acetylcholinesterase (-1) BE0000749 Sodium-dependent serotonin transporter (-1) BE0000756 D(2) dopamine receptor (1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000020 D(1A) dopamine receptor (1) Non-common off-target(s) (drug2) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000659 5-hydroxytryptamine receptor 1D (-1) BE0000797 5-hydroxytryptamine receptor 1B (-1) BE0000476 5-hydroxytryptamine receptor 1E (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000311 5-hydroxytryptamine receptor 3A (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) --------------------------------------------------- Drug1 : DB00805 Minaprine Drug2 : DB06216 Asenapine Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Common off-target (-,-) : BE0000533 5-hydroxytryptamine receptor 2C Common off-target (-,-) : BE0000393 5-hydroxytryptamine receptor 2B Common off-target (+,-) : BE0000756 D(2) dopamine receptor Common off-target (+,-) : BE0000020 D(1A) dopamine receptor Non-common off-target(s) (drug1) : BE0000426 Acetylcholinesterase (-1) BE0000749 Sodium-dependent serotonin transporter (-1) BE0000092 Muscarinic acetylcholine receptor M1 (1) BE0002198 Amine oxidase [flavin-containing] A (-1) Non-common off-target(s) (drug2) : BE0000172 Beta-1 adrenergic receptor (-1) BE0000694 Beta-2 adrenergic receptor (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000442 Histamine H1 receptor (-1) BE0000797 5-hydroxytryptamine receptor 1B (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000650 5-hydroxytryptamine receptor 7 (-1) BE0000581 D(3) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000945 5-hydroxytryptamine receptor 6 (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (-1) BE0000112 Histamine H2 receptor (-1) BE0004688 5-hydroxytryptamine receptor 5A (-1) --------------------------------------------------- Drug1 : DB00844 Nalbuphine Drug2 : DB06274 Alvimopan Pharmacological target (-,-) : BE0000770 Mu-type opioid receptor Common off-target (-,-) : BE0000420 Delta-type opioid receptor Common off-target (+,-) : BE0000632 Kappa-type opioid receptor --------------------------------------------------- Drug1 : DB01149 Nefazodone Drug2 : DB01363 Ephedra Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Common off-target (-,-) : BE0000647 Sodium-dependent dopamine transporter Common off-target (+,-) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0000172 Beta-1 adrenergic receptor (1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000694 Beta-2 adrenergic receptor (1) BE0004674 Chromaffin granule amine transporter (-1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) BE0001012 Beta-3 adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01149 Nefazodone Drug2 : DB01577 Methamphetamine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Pharmacological target (-,-) : BE0000486 Sodium-dependent noradrenaline transporter Common off-target (-,-) : BE0000647 Sodium-dependent dopamine transporter Common off-target (+,-) : BE0000289 Alpha-2A adrenergic receptor Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000451 5-hydroxytryptamine receptor 2A (-1) Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (-1) BE0001044 Trace amine-associated receptor 1 (1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0004674 Chromaffin granule amine transporter (-1) BE0000572 Alpha-2B adrenergic receptor (1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01175 Escitalopram Drug2 : DB01472 4-Methoxyamphetamine Pharmacological target (-,-) : BE0000749 Sodium-dependent serotonin transporter Common off-target (-,-) : BE0000647 Sodium-dependent dopamine transporter Common off-target (+,-) : BE0000501 Alpha-1A adrenergic receptor Non-common off-target(s) (drug1) : BE0000486 Sodium-dependent noradrenaline transporter (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000442 Histamine H1 receptor (-1) Non-common off-target(s) (drug2) : BE0000118 Synaptic vesicular amine transporter (-1) BE0002196 Amine oxidase [flavin-containing] B (-1) BE0002198 Amine oxidase [flavin-containing] A (-1) BE0000289 Alpha-2A adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01239 Chlorprothixene Drug2 : DB01267 Paliperidone Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Pharmacological target (-,-) : BE0000533 5-hydroxytryptamine receptor 2C Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Pharmacological target (-,-) : BE0000581 D(3) dopamine receptor Common off-target (-,-) : BE0000020 D(1A) dopamine receptor Common off-target (+,-) : BE0000442 Histamine H1 receptor Non-common off-target(s) (drug1) : BE0000045 Muscarinic acetylcholine receptor M3 (-1) BE0000092 Muscarinic acetylcholine receptor M1 (-1) BE0000560 Muscarinic acetylcholine receptor M2 (-1) BE0000393 5-hydroxytryptamine receptor 2B (-1) BE0000405 Muscarinic acetylcholine receptor M4 (-1) BE0000247 Muscarinic acetylcholine receptor M5 (-1) Non-common off-target(s) (drug2) : BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000659 5-hydroxytryptamine receptor 1D (-1) BE0000291 5-hydroxytryptamine receptor 1A (-1) BE0000389 D(4) dopamine receptor (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) BE0000342 Alpha-2C adrenergic receptor (1) --------------------------------------------------- Drug1 : DB01267 Paliperidone Drug2 : DB08815 Lurasidone Pharmacological target (-,-) : BE0000756 D(2) dopamine receptor Pharmacological target (-,-) : BE0000451 5-hydroxytryptamine receptor 2A Common off-target (-,-) : BE0000291 5-hydroxytryptamine receptor 1A Common off-target (+,-) : BE0000342 Alpha-2C adrenergic receptor Non-common off-target(s) (drug1) : BE0000533 5-hydroxytryptamine receptor 2C (-1) BE0000501 Alpha-1A adrenergic receptor (-1) BE0000575 Alpha-1B adrenergic receptor (-1) BE0000442 Histamine H1 receptor (1) BE0000659 5-hydroxytryptamine receptor 1D (-1) BE0000020 D(1A) dopamine receptor (-1) BE0000581 D(3) dopamine receptor (-1) BE0000389 D(4) dopamine receptor (-1) BE0000289 Alpha-2A adrenergic receptor (-1) BE0000572 Alpha-2B adrenergic receptor (-1) Non-common off-target(s) (drug2) : BE0000650 5-hydroxytryptamine receptor 7 (-1) ---------------------------------------------------