Constructing network topologies for multiple signal-encoding functions

refer to: circuit N5 in Fig.4c, Equqtions 2, Fig. 5

I1=0.4, I2=I3=0.1, output oscillation

I2=0.3, I1=I3=0.1, output adaptation

I3=0.3, I1=I2=0.1, output sustained activation

The enzymatic reactions look like these:

( the sign _ denotes enzyme in its inactive form)

reaction_1: I1 + R1_ -> R1; V1*I1*(1-R1)/(K1+1-R1);

reaction_2: R3 + R1 -> R3 + R1_; V5*R3*R1/(K5+R1);

reaction_3: I2 + R2_ -> R2; V2*I2*(1-R2)/(K2+1-R2);

reaction_4: B + R2 -> B + R2_; V6*B*R2/(K6+R2);

reaction_5: I3 + R3_ -> R3; V3*I3*(1-R3)/(K3+1-R3);

reaction_6: O + R3 -> O + R3_; V7*O*R3/(K7+R3);

reaction_7: R2 + O_ -> R2 + O; V4*R2*(1-O)/(K4+1-O);

reaction_8: R1 + O -> R1 + O_; V8*R1*O/(K8+O);