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{"sheet":"apoptosis","index":0,"n_rows":82,"n_cols":7,"rows_kept":82,"flags":["formulas_cached_only"]}
[null,null,"DEGs related to apoptosis"]
[]
[1,"effect of p53 on this target","→","P53 is a transcriptional inducer of this gene"]
[null,null,"┤","P53 is a transcriptional repressor of this gene"]
[null,null,"→ ┤","P53 can be both a transcriptional inducer and a repressor of this gene"]
[2,"Description",null,"Short description of DEG function as arised from the literature"]
[3,"Leukemic subtype","A (CN-AML), B (APL)","DEG expressed in either of the subtypes or in both (in the same direction)"]
[4,"Differential expression",null,"up- gene expression is upregulated"]
[{"$nulls":3},"down- gene expression is downregulated"]
[5,null,null,"Genes that suggest stimulation of apoptosis"]
[{"$nulls":3},"Genes that suggest inhibition of apoptosis"]
[]
["DEGs that suggest stimulation of apoptosis via induction by p53-"]
["Official Symbol","Official Full Name","Other Aliases:","effect of p53 on this target","Description","Leukemic subtype","Differential expression"]
["PMAIP","phorbol-12-myristate-13-acetate-induced protein 1","NOXA; APR; PMAIP1","→","Proapoptotic","A","up"]
["ZMAT3","zinc finger, matrin type 3","WIG1; WIG-1; PAG608; FLJ12296; MGC10613","→","Proapoptotic","A","up"]
["SIAH1","seven in absentia homolog 1 (Drosophila)","Siah-1; hSIAH1; HUMSIAH; Siah-1a; FLJ08065","→","E3 ligase,  induction of apoptosis","B","up"]
["PRODH","proline dehydrogenase (oxidase) 1","POX; PIG6; SCZD4; HSPOX2; PRODH1; PRODH2; TP53I6; FLJ33744; MGC148078; MGC148079","→","Upregulation of this pro-oxidant enzyme leads to oxidative stress (ROS-generating enzyme) and consequently to apoptosis","B","up"]
["LATS2","large tumor suppressor, homolog 2 (Drosophila)","FLJ13161, KPM","→","ATR-Chk1-mediated stress→induction of p53 activity, upregulation of proapoptotic genes, downregulation of antiapoptotic genes and eventually apoptotic cell death.","A, B","up"]
["PLAGL1","pleiomorphic adenoma gene-like 1","ZAC; LOT1; ZAC1; MGC126275; MGC126276; DKFZp781P1017","→","p53 activation of the Apaf-1 luciferase construct can be enhanced by Zac-1.","A","up"]
["EGR1","early growth response 1","TIS8; AT225; G0S30; NGFI-A; ZNF225; KROX-24; ZIF-268","→","required for apoptosis","A","up"]
[]
["DEGs that suggest stimulation of apoptosis via repression of anti-apoptotic genes by p53-"]
["BIRC5","baculoviral IAP repeat-containing 5","Survivin; API4; EPR-1","┤","anti-apoptotic gene","A, B","down"]
["SERPINB2","serpin peptidase inhibitor, clade B (ovalbumin), member 2","PAI-2; PAI; PAI2; PLANH2; HsT1201","┤","anti-apoptotic gene","A, B","down"]
["LGALS3","lectin, galactoside-binding, soluble, 3","GAL3; MAC2; CBP35; GALBP; GALIG; LGALS2","┤","anti-apoptotic gene","A, B","down"]
["PSRC1","proline/serine-rich coiled-coil 1","DDA3; FP3214; MGC1780; RP11-297O4.2","┤","anti-apoptotic","B","down"]
["BUB1","budding uninhibited by benzimidazoles 1 homolog (yeast)","BUB1A; BUB1L; hBUB1","┤","kinase involved in spindle checkpoint function, inhibits apoptosis","B","down"]
[]
["Other DEGs that suggest stimulation of apoptosis-"]
["WTAP","Wilms tumor 1 associated protein","MGC3925; KIAA0105; DKFZp686F20131",null,"inhibiting WT1 transcriptional activity, WTAP represses BCL2 and amphiregulin genes that are activated by wt-1=  buffers the ability of WT1 to stimulate proliferation and suppress apoptosis  ","A","up"]
["SOX4","SRY (sex determining region Y)-box 4","EVI16",null,"promotes p53-dependent apoptosis","A","up"]
["TXN","thioredoxin","TRX; TRX1; MGC61975; DKFZp686B1993",null,"participates in p53-dependent apoptosis following redox","A","up"]
["CASP2","caspase 2, apoptosis-related cysteine peptidase","ICH1; NEDD2; CASP-2; ICH-1L; ICH-1L/1S",null,"needed for p53- induced apoptosis, P53 stimulated caspase-2/-3 protein activities. Can be parallel to regular cascades.","A, B","up"]
["CABLES1","Cdk5 and Abl enzyme substrate 1","IK3-1; CABLES; HsT2563; FLJ35924",null,"indices p53- apoptosis","B","up"]
["GLIPR1","GLI pathogenesis-related 1","GLIPR; RTVP1; CRISP7",null,"has P53-dependent and -independent proapoptotic activities. It expression is induced by DNA-damaging agents independent of p53","A","up"]
["SESN3","sestrin 3","SEST3; MGC29667",null,"AKT activation→ROS↑→sestrin 3 repression→ ROS-mediated apoptosis.","A, B","down"]
["IER3","immediate early response 3","IEX1;DIF2; PRG1; DIF-2; GLY96; IEX-1; IEX-1L","┤→","protection of cells from Fas- or TNF alpha-induced apoptosis (anti-apoptotic), growth promoting","A, B","down"]
["GTSE1","G-2 and S-phase expressed 1","B99","┤→","hGTSE-1↓→ sensitization to DNA damage-induced apoptosis, anti-apoptotic p53 target ","A, B","down"]
["SOD2","superoxide dismutase 2, mitochondrial","IPO-B; MNSOD; MVCD6; Mn-SOD","┤→","anti-apoptotic p53 target","A, B","down"]
["RRM2","ribonucleotide reductase M2 polypeptide","p53R2 ; R2; RR2M","┤→","anti-apoptotic p53 target","A, B","down"]
["PTGS2","prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)","COX2; COX-2; PHS-2; PGG/HS; PGHS-2; hCox-2; GRIPGHS","┤→","anti-apoptotic p53 target","B","down"]
["TNFRSF10C","tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain","DCR1;LIT; TRID; CD263; TRAILR3; MGC149501; MGC149502","→","anti-apoptotic p53 target","A, B","down"]
["FHL2","four and a half LIM domains 2","DRAL; AAG11; SLIM3",null,"anti-apoptotic p53 target","A, B","down"]
["BCL2A1","BCL2-related protein A1","A1; GRS; BFL1; ACC-1; ACC-2; HBPA1; BCL2L5","┤→","anti-apoptotic gene","A","down"]
["HBXIP","hepatitis B virus x interacting protein","XIP; MGC71071",null,"decreases activation of caspase 9= anti-apoptotic","B","down"]
["MXD1","MAX dimerization protein 1","MAD; MAD1; bHLHc58; MGC104659",null,"when high- suppress p53-mediated apoptosis (anti-apoptotic)","A","down"]
[]
["DEGs that suggest inhibition of apoptosis since no induction of pro-apoptotic genes by p53-"]
["BID","BH3 interacting domain death agonist","FP497; MGC15319; MGC42355","→","Proapoptotic","A, B","down"]
["BIK","BCL2-interacting killer (apoptosis-inducing)","NBK; BP4; BIP1","→","Proapoptotic","A","down"]
["BNIP3L","BCL2/adenovirus E1B 19kDa interacting protein 3-like","NIX; BNIP3a","→","Proapoptotic","A","down"]
["NLRC4","NLR family, CARD domain containing 4","IPAF;CLAN; CLAN1; CLANA; CLANB; CLANC; CLAND; CARD12; CLR2.1","→","activator of caspase-1 (initiator caspase)","A, B","down"]
["TNFSF10","tumor necrosis factor (ligand) superfamily, member 10","TRAIL; TL2; APO2L; CD253; Apo-2L","→","Proapoptotic","A, B","down"]
["CASP1","caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)","ICE; P45; IL1BC","→","pro-apoptotic","B","down"]
["CYFIP2","cytoplasmic FMR1 interacting protein 2","PIR121","→","pro-apoptotic","B","down"]
["RNF144B","ring finger protein 144B","IBRDC2; p53RFP; KIAA0161; MGC71786; bA528A10.3","→","pro-apoptotic","B","down"]
["RPS27L","ribosomal protein S27-like",null,"→","mediates p53-dependent induction of apoptosis","B","down"]
["DUSP2","dual specificity phosphatase 2","PAC1; PAC-1","→","inactivates Erk1 and Erk2→ apoptosis induction","B","down"]
["EI24","etoposide induced 2.4 mRNA","PIG8; TP53I8","→","Proapoptotic","A, B","down"]
[]
["Other DEGs that suggest inhibition of apoptosis-"]
["BCL2","B-cell CLL/lymphoma 2","Bcl-2","┤","inhibit p53-dependent apoptosis, induced by WT1","A","up"]
["BCL2L1","BCL2-like 1","bcl-xL; BCLX; BCL2L; Bcl-X; bcl-xS; BCL-XL/S; DKFZp781P2092",null,"Anti-apoptotic, Genotoxic stress induced by oxaliplatin elicits an ATM-, CHK2-, and p53-dependent splicing switch that favors the production of the proapoptotic Bcl-xS variant.","B","up"]
["WT1","Wilms tumor 1","GUD; WAGR; WT33; WIT-2",null,"Bcl-2 is also transcriptionally activated by WT1 leading to suppressed apoptosis","A, B","up"]
["KPNB1","karyopherin (importin) beta 1","IMB1; IPO1; IPOB; Impnb; NTF97; MGC2155; MGC2156; MGC2157","┤","member of the importin beta family, p53  protein expression was found to be elevated in Kpnb1 knock-down cells→apoptosis\n","A","up"]
["IGF1R","insulin-like growth factor 1 receptor","IGFR; CD221; IGFIR; JTK13; MGC18216; MGC142170; MGC142172","┤","Anti-apoptotic,  inhibition of IGF-1R reduces p53 and Mdm2 translation","B","up"]
["BMI1","BMI1 polycomb ring finger oncogene","PCGF4; RNF51; MGC12685",null,"downregulation of p53-mediated apoptosis","A","up"]
["EGFR","epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)","ERBB; HER1; mENA; ERBB1; PIG61","→","Activation of Akt therefore anti-apoptotic","A, B","up"]
["BCL2L11","BCL2-like 11 (apoptosis facilitator)","BIM; BAM; BOD; BimL; BimEL; BIM-beta6; BIM-beta7; BIM-alpha6",null,"activator of Bax/Bak, not Puma or p53-related","A","down"]
["BTG1","B-cell translocation gene 1, anti-proliferative","involved in a t(8;12) in a case of B-CLL",null,"BTG1 expression seems to be negatively regulated by Bcl-2, and exogenous expression of BTG1 induced apoptosis","A, B","down"]
["S100A6","S100 calcium binding protein A6","2A9; PRA; 5B10; CABP; CACY",null,"Proapoptotic","A, B","down"]
["SMAD7","SMAD family member 7","CRCS3; MADH7; MADH8; FLJ16482",null,"TGFbeta1-induced activation of ATM and p53 mediates apoptosis in a Smad7-dependent manner","A, B","down"]
["STAT1","signal transducer and activator of transcription 1, 91kDa","ISGF-3; STAT91; DKFZp686B04100",null,"ATM, p53, STAT1 (transcription activator) and c-Abl1 associate together- induction of apoptosis","A, B","down"]
["MKRN1","makorin ring finger protein 1","RNF61; FLJ21334",null,"transcriptional co-regulator and an E3 ligase, stimulating cell death by repressing p21 under stress conditions","A","down"]
["KLF5","Kruppel-like factor 5 (intestinal)","CKLF; IKLF; BTEB2",null,"KLF5 T↑→cell cycle arrest and apoptosis↑, p53-independent apoptosis","A, B","down"]
["GADD45G","growth arrest and DNA-damage-inducible, gamma","CR6; DDIT2; GRP17; GADD45gamma",null,"Pro-apoptotic after stress","A, B","down"]
["PRKCD","protein kinase C, delta","MAY1; PKCD; MGC49908; nPKC-delta",null,"actively involved in cell apoptosis in a stimulus and tissue specific manner; it both regulates the expression and function of apoptotic related proteins and is itself a target for caspases.","A","down"]
["SCD","stearoyl-CoA desaturase (delta-9-desaturase)","SCD1; FADS5; SCDOS; MSTP008","┤","cell membrane fluidity and signal transduction,  induction of either apoptosis or senescence","A, B","down"]
[]
["DEGs that impact is not clear-"]
["CLU","clusterin","CLI; AAG4; APOJ; KUB1; SGP2; SGP-2; SP-40; TRPM2; TRPM-2; MGC24903","┤→","Can be both pro and anti-apoptotic","A, B","down"]