{"text_format":"3","workbook":"xls","n_sheets":1,"sheets":["DNA repair"],"read":"whole","date_system":"1900","formulas":"cached_only"}

{"sheet":"DNA repair","index":0,"n_rows":25,"n_cols":7,"rows_kept":25,"flags":["formulas_cached_only"]}
[null,null,"DEGs related to DNA repair"]
[]
[1,"effect of p53 on this target","→","P53 is a transcriptional inducer of this gene"]
[null,null,"┤","P53 is a transcriptional repressor of this gene"]
[null,null,"→ ┤","P53 can be both a transcriptional inducer and a repressor of this gene"]
[2,"Description",null,"Short description of DEG function as arised from the literature"]
[3,"Leukemic subtype","A (CN-AML), B (APL)","DEG expressed in either of the subtypes or in both (in the same direction)"]
[4,"Differential expression",null,"up- gene expression is upregulated"]
[{"$nulls":3},"down- gene expression is downregulated"]
[5,null,null,"Genes that suggest activation of  DNA repair"]
[{"$nulls":3},"Genes that suggest inhibition of  DNA repair"]
[]
["Genes that suggest activation of DNA repair-"]
["Official Symbol","Official Full Name","Other Aliases:","effect of p53 on this target","Description","Leukemic subtype","Differential expression"]
["CASP2","caspase 2, apoptosis-related cysteine peptidase","ICH1; NEDD2; CASP-2; ICH-1L; ICH-1L/1S",null,"recruits components of NHEJ (catalitic subunit of DNA-PK)","A, B","up"]
[]
["Genes that suggest inhibition of DNA repair-"]
["GADD45A","growth arrest and DNA-damage-inducible, alpha","DDIT1; GADD45","┤→","induced by p53 in hypoxia. In response to nitric oxide, FoxO1 translocates from the cytoplasm to the nucleus and stimulates the expression of the DNA repair gene GADD45α, resulting in FoxO1-dependent DNA repair. GADD45  interaction with PCNA plays a role in nucleotide excision repair of DNA","B","down"]
["RRM2","ribonucleotide reductase M2 polypeptide","p53R2 ; R2; RR2M","┤→","p53-dependent DNA repair↑","A, B","down"]
["RAD23A","RAD23 homolog A (S. cerevisiae)","HHR23A; MGC111083",null,"nucleotide excision repair (NER),a role in DNA damage recognition in BER","A, B","down"]
["RAD51","RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae)","RECA; BRCC5; HRAD51; RAD51A; HsRad51; HsT16930"," ┤","homologous recombination and repair of DNA, p53-dependent antirecombinogenic activity can be attributed to p53 binding to hRAD51 directly","B","down"]
["PCNA","proliferating cell nuclear antigen","MGC8367"," ┤","speeds DNA replication and repair ","B","down"]
["DUT","deoxyuridine triphosphatase","dUTPase; FLJ20622","┤","Part of repair process which is self-defeating and leads to DNA fragmentation and cell death. ","B","down"]
["S100A11","S100 calcium binding protein A11","MLN70; S100C",null,"targets Rad54B (HR) to sites of DNA DSB repair sites","A","down"]
["GTF2B","general transcription factor IIB","TF2B; TFIIB",null,"differential cofactor for p53 action after distinct types of DNA damage","B","down"]