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{"sheet":"oxidative stress","index":0,"n_rows":19,"n_cols":7,"rows_kept":19,"flags":["formulas_cached_only"]}
[null,null,"DEGs related oxidative stress"]
[]
[1,"effect of p53 on this target","→","P53 is a transcriptional inducer of this gene"]
[null,null,"┤","P53 is a transcriptional repressor of this gene"]
[null,null,"→ ┤","P53 can be both a transcriptional inducer and a repressor of this gene"]
[2,"Description",null,"Short description of DEG function as arised from the literature"]
[3,"Leukemic subtype","A (CN-AML), B (APL)","DEG expressed in either of the subtypes or in both (in the same direction)"]
[4,"Differential expression",null,"up- gene expression is upregulated"]
[{"$nulls":3},"down- gene expression is downregulated"]
[5,null,null,"Genes that suggest inhibition of ROS defence"]
[]
["Genes that suggest inhibition of ROS defence since no induction by p53-"]
["Official Symbol","Official Full Name","Other Aliases:","effect of p53 on this target","Description","Leukemic subtype","Differential expression"]
["SESN2","sestrin 2","HI95; SES2; SEST2; DKFZp761M0212; DKFZp761M02121","→","decreasing the levels of ROS=anti-oxidant","A","down"]
["SOD2","superoxide dismutase 2, mitochondrial","IPO-B; MNSOD; MVCD6; Mn-SOD","┤→","mitochondrial antioxidant system, high p53 repress Mn-SOD→cellular ROS↑.  ","A, B","down"]
["C12orf5","chromosome 12 open reading frame 5","TIGAR (TP53-induced glycolysis and apoptosis regulator)","→","anti-oxidant, blocking glycolysis","B","down"]
[]
["Genes that show increase in pro-oxidant response via induction of p53-"]
["PRODH","proline dehydrogenase (oxidase) 1","POX; PIG6; SCZD4; HSPOX2; PRODH1; PRODH2; TP53I6; FLJ33744; MGC148078; MGC148079","→","ROS-generating pro-oxidant enzyme. Upregulation of this pro-oxidant enzyme leads to oxidative stress and consequently to apoptosis","B","up"]