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{"sheet":"p53 transcription","index":0,"n_rows":29,"n_cols":7,"rows_kept":29,"flags":["formulas_cached_only"]}
[null,null,"DEGs related to transcription of p53 gene"]
[]
[1,"effect of p53 on this target","→","P53 is a transcriptional inducer of this gene"]
[null,null,"┤","P53 is a transcriptional repressor of this gene"]
[null,null,"→ ┤","P53 can be both a transcriptional inducer and a repressor of this gene"]
[2,"Description",null,"Short description of DEG function as arised from the literature"]
[3,"Leukemic subtype","A (CN-AML), B (APL)","DEG expressed in either of the subtypes or in both (in the same direction)"]
[4,"Differential expression",null,"up- gene expression is upregulated"]
[{"$nulls":3},"down- gene expression is downregulated"]
[5,null,null,"Genes that suggest increased transcription of p53 gene"]
[{"$nulls":3},"Genes that suggest decreased transcription of p53 gene"]
[]
["Genes that suggest increased transcription of p53 gene-"]
["Official Symbol","Official Full Name","Other Aliases:","effect of p53 on this target","Description","Leukemic subtype","Differential expression"]
["TP53","tumor protein p53","FLJ92943, LFS1, TRP53",null,"p53 mediates an autoregulatory positive loop of self transcription ","A,B","up"]
["ZMAT3","zinc finger, matrin type 3","WIG1; WIG-1; PAG608; FLJ12296; MGC10613","→","binds to double-stranded RNA and enhances p53 mRNA stability by binding to the 3'UTR in a positive feedback loop","A","up"]
["EGR1","early growth response 1","TIS8; AT225; G0S30; NGFI-A; ZNF225; KROX-24; ZIF-268","→","induce p53 expression","A","up"]
["TXN","thioredoxin","TRX; TRX1; MGC61975; DKFZp686B1993",null,"can upregulate p53 gene expression","A","up"]
["BCL6","B-cell CLL/lymphoma 6","BCL5; LAZ3; BCL6A; ZNF51; ZBTB27",null,"repression of p53-gene transcription","A, B","down"]
["SOD2","superoxide dismutase 2, mitochondrial","Mn-SOD; IPO-B; MNSOD; MVCD6 ","┤→","overexpression of MnSOD decrease p53 gene expression","A, B","down"]
["KLF4","Kruppel-like factor 4 (gut)","EZF; GKLF",null,"suppresses the expression of p53 by directly acting on its promoter","A, B","down"]
["PAX5","paired box 5","BSAP",null,"inhibits p53 gene transcription","A, B","down"]
[]
[]
["Genes that suggest decreased transcription of p53 gene-"]
["NFIC","nuclear factor I/C (CCAAT-binding transcription factor)","NFI; CTF; CTF5; NF-I; MGC20153",null,"transcription factor, activator of p53 gene promotor","A, B","down"]
["PRKCD","protein kinase C, delta","MAY1; PKCD; MGC49908; nPKC-delta",null,"transactivates TP53 expression at the transcriptional level","A","down"]
["ETS1","v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)","ETS-1; EWSR2; FLJ10768",null,"activator of p53 transcription","B","down"]
["ETS2","v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)","ETS2IT1",null,"activator of p53 transcription","B","down"]