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{"sheet":"p53 transcriptional functioning","index":0,"n_rows":44,"n_cols":7,"rows_kept":44,"flags":["formulas_cached_only"]}
[null,null,"DEGs related to transcriptional functioning of p53"]
[]
[1,"effect of p53 on this target","→","P53 is a transcriptional inducer of this gene"]
[null,null,"┤","P53 is a transcriptional repressor of this gene"]
[null,null,"→ ┤","P53 can be both a transcriptional inducer and a repressor of this gene"]
[2,"Description",null,"Short description of DEG function as arised from the literature"]
[3,"Leukemic subtype","A (CN-AML), B (APL)","DEG expressed in either of the subtypes or in both (in the same direction)"]
[4,"Differential expression",null,"up- gene expression is upregulated"]
[{"$nulls":3},"down- gene expression is downregulated"]
[5,null,null,"Genes that suggest increased p53 transcriptional functioning"]
[{"$nulls":3},"Genes that suggest decreased p53 transcriptional functioning"]
[{"$nulls":3},"Genes that appear more than once"]
[]
["Genes that suggest increased p53 transcriptional functioning-"]
["Official Symbol","Official Full Name","Other Aliases:","effect of p53 on this target","Description","Leukemic subtype","Differential expression"]
["ZNF148","zinc finger protein 148","ZBP-89;BERF-1; BFCOL1; ZFP148; pHZ-52; HT-BETA",null,"enhance p53 transcriptional activity by retaining it in the nucleus","A","up"]
["DDX17","DEAD (Asp-Glu-Ala-Asp) box polypeptide 17","P72; RH70; DKFZp761H2016",null,"less potent co-activator of p53 transcriptional activity ","A, B","up"]
["YEATS4","YEATS domain containing 4","GAS41; YAF9; NUBI-1; 4930573H17Rik; B230215M10Rik",null,"repression of p53 transcriptional activity","B","down"]
["HIST1H1C","histone cluster 1, H1c","H1C; H1.2; H1F2; MGC3992",null,"repress p53-dependent and p300-mediated chromatin transcription","B","down"]
["ID2","inhibitor of DNA binding 2, dominant negative helix-loop-helix protein","GIG8; ID2A; ID2H; bHLHb26; MGC26389","→","negative transcriptional regulator","B","down"]
["E2F8","E2F transcription factor 8","FLJ23311",null,"repressor  of  E2F/proliferation, deficiency in E2f7 and E2f8 led to an increase in E2f1 and p53 protein and p53 tr. activity.","A, B","down"]
["TFDP1","transcription factor Dp-1","DP1; Dp-1; DRTF1",null,"transcription factors that heterodimerize with E2F proteins, p53 interacts with  E2F1 and DP1, p53 can inhibit the transcriptional activity of E2F, and the expression of both E2F1 and DP1 can also downregulate p53-dependent transcription.","A, B","down"]
["PADI4","peptidyl arginine deiminase, type IV","PAD4; PAD; PDI4; PDI5; PADI5","→","PADI4 (histone Arg citrullination) interact with  HDAC2 and p53 and sit on p21, GADD45, and PUMA p53-target gene promoters àinhibition of expression. but they dissociate after DNA damage. ","A, B","down"]
[]
["Genes that suggest decreased p53 transcriptional functioning-"]
["MDM4","Mdm4 p53 binding protein homolog (mouse)","HDMX; MDMX; MRP1; MGC132766; DKFZp781B1423",null,"inhibits p53 tr. activity","A, B","up"]
["S100A6","S100 calcium binding protein A6","2A9; PRA; 5B10; CABP; CACY",null,"higher p53 transcriptional activity ","A, B","down"]
["GTF2B","general transcription factor IIB","TF2B; TFIIB",null,"differential cofactor for p53 action after distinct types of DNA damage","B","down"]
["SP100","SP100 nuclear antigen","FLJ00340; FLJ34579; DKFZp686E07254",null,"coactivator for HIPK2-mediated p53 activation","B","down"]
["FTH1","ferritin, heavy polypeptide 1","FHC; FTH; PLIF; FTHL6; PIG15; MGC104426","┤","ferritin increases the transcriptional activity of p53","B","down"]
["TADA2B","transcriptional adaptor 2B","ADA2B; MGC21874; ADA2(beta);",null,"needed for optimal binding of  acetyltransferase GCN5L to p53","B","down"]
["HDAC4","histone deacetylase 4","HD4; AHO3; BDMR; HDACA; HA6116; HDAC-A; KIAA0288",null,"needed for repression of G2/M promotors together with p53","A","down"]
[]
["Genes that impact is not clear-"]
["MEF2C","myocyte enhancer factor 2C",null,null,"Repression of p53-dependent transactivation","B","down"]
["MEF2C","myocyte enhancer factor 2C",null,null,"Repression of p53-dependent transactivation","A","up"]
["RUNX2","runt-related transcription factor 2","CCD; AML3; CCD1; OSF2; CBFA1; PEA2aA; PEBP2A1; PEBP2A2; PEBP2aA; PEBP2aA1; MGC120022; MGC120023","┤","transcription factor, p53-dependent hypoxia-repressed genes","A","up"]
["E2F2","E2F transcription factor 2","E2F-2",null,"E2F2 can both induce and inhibit p53 function","A","down"]
["PTTG1","pituitary tumor-transforming 1","Securin; EAP1; PTTG; HPTTG; TUTR1; MGC126883; MGC138276, ",null,"anaphase-promoting complex (APC) substrate, PTTG1 can both induce and inhibit p53 function","A, B","down"]
["SP3","Sp3 transcription factor","SPR-2; DKFZp686O1631",null,"co-operate functionally with p53 for the synergistic transactivation of the p21Cip1 promoter","A, B","down"]
["TOP1","topoisomerase (DNA) I","TOPI",null,"regulation at protein level","A","down"]
["TOP2A","topoisomerase (DNA) II alpha 170kDa","TOP2; TP2A","┤","activation/or not of topoisomerase IIalpha protein,regulation at protein level ","A, B","down"]
["ASF1A","ASF1 anti-silencing function 1 homolog A (S. cerevisiae)","CIA; CGI-98; HSPC146; DKFZp547E2110",null,"cooperates with p53 to make SAHF            (senescence-associated heterochromatin foci)","B","down"]
["BCL6","B-cell CLL/lymphoma 6","BCL5; LAZ3; BCL6A; ZNF51; ZBTB27",null,"cell context-dependent","A, B","down"]