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{"sheet":"p53 stability","index":0,"n_rows":41,"n_cols":7,"rows_kept":41,"flags":["formulas_cached_only"]}
[null,null,"DEGs related to stability of p53 protein"]
[]
[1,"effect of p53 on this target","→","P53 is a transcriptional inducer of this gene"]
[null,null,"┤","P53 is a transcriptional repressor of this gene"]
[null,null,"→ ┤","P53 can be both a transcriptional inducer and a repressor of this gene"]
[2,"Description",null,"Short description of DEG function as arised from the literature"]
[3,"Leukemic subtype","A (CN-AML), B (APL)","DEG expressed in either of the subtypes or in both (in the same direction)"]
[4,"Differential expression",null,"up- gene expression is upregulated"]
[{"$nulls":3},"down- gene expression is downregulated"]
[5,null,null,"Genes that suggest increased stability of p53 protein"]
[{"$nulls":3},"Genes that suggest decreased stability of p53 protein"]
[]
["Genes that suggest increased p53 protein stability-"]
["Official Symbol","Official Full Name","Other Aliases:","effect of p53 on this target","Description","Leukemic subtype","Differential expression"]
["WT1","Wilms tumor 1","GUD; WAGR; WT33; WIT-2",null,"WT1 protects p53 from degradation","A, B","up"]
["LATS2","large tumor suppressor, homolog 2 (Drosophila)","FLJ13161, KPM","→","prevents Mdm2-driven p53 degradation","A, B","up"]
["SOX4","SRY (sex determining region Y)-box 4","EVI16",null,"stabilizes p53 protein by blocking Mdm2-mediated p53 ubiquitination and degradation","A","up"]
["CASP2","caspase 2, apoptosis-related cysteine peptidase","ICH1; NEDD2; CASP-2; ICH-1L; ICH-1L/1S",null,"Caspase-2 directly cleaves tMdm2 at Asp 367→ loss of the C-terminal RING domain responsible for p53 ubiquitination→ p53stability","A, B","up"]
["ZNF148","zinc finger protein 148","ZBP-89;BERF-1; BFCOL1; ZFP148; pHZ-52; HT-BETA",null,"binds p53 and Mdm2→nuclear retention of p53->stabilize p53","A","up"]
["S100B","S100 calcium binding protein B","NEF; S100; S100beta",null,"Can protect p53 from acquiring the modifications that target it for degradation","B","up"]
["DHCR24","24-dehydrocholesterol reductase","seladin-1; KIAA0018; SELADIN1; Nbla03646; ",null,"Required for p53-mediated cellular response to ROS by p53 accumulation","B","up"]
["MEG3","maternally expressed 3 (non-protein coding)","GTL2; FP504; prebp1; PRO0518; PRO2160; FLJ31163; FLJ42589; FLJ44703; NCRNA00023",null,"induce p53 accumulation","B","up"]
["RPS27","ribosomal protein S27","MPS1; MPS-1","┤","in vivo triplex with MDM2-p53 and competes with p53 for MDM2 binding","B","up"]
["GTSE1","G-2 and S-phase expressed 1","B99",null,"hGTSE-1↓-->  S/G2-specific increase of p53 levels, after DNA damage shuttling p53 out of the nucleus ","A","down"]
["EP300","E1A binding protein p300","p300; KAT3B",null,"also targets p53 for ubiquitination","A, B","down"]
["SGK1","serum/glucocorticoid regulated kinase 1","SGK","┤→","activates MDM2-dependent p53 ubiquitylation","A, B","down"]
["UBE2D1","ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast)","SFT; UBCH5; UBC4/5; UBCH5A; E2(17)KB1",null,"p53 is polyubiquitinated in the presence of E1, UbcH5 as E2 and MDM2 oncoprotein","A, B","down"]
["DLGAP5","discs, large (Drosophila) homolog-associated protein 5","DLG7; HURP; KIAA0008","┤","Overexpression of HURP in HEK293 cells promoted the ubiquitination of p53 and its degradation by the proteasome","A, B","down"]
["RAD23A","RAD23 homolog A (S. cerevisiae)","HHR23A; MGC111083",null,"hHR23 binds to polyubiquitin chains formed on p53 and protects them from deubiquitylation→  delivers the polyubiquitylated p53 molecules to the proteasome","A, B","down"]
["PTK2","PTK2 protein tyrosine kinase 2","FAK; FADK; FAK1; pp125FAK","┤","enhanced Mdm2-dependent p53 ubiquitination","B","down"]
[]
["Genes that suggest decreased p53 protein stability-"]
["CUL4A","cullin 4A",null,null,"E3 ubiquitin ligase component of a multimeric complex,   physically associates with MDM2 and participates in the proteolysis of p53","B","up"]
["UBE2I","ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)","P18; UBC9; C358B7.1",null,"E2 ligase for sumoylation,  direct interaction of Ubc9 with p53","B","up"]
["TTK","TTK protein kinase","MPS1; ESK; PYT; CT96; MPS1L1; FLJ38280",null,"phoshorylates p53 at Thr18-->abrogates MDM2-mediated p53 ubiquitination","A, B","down"]
["MAPK1","mitogen-activated protein kinase 1","ERK; ERK2;p38; MAPK1; p40; p41; ERK2; ERT1; MAPK2; PRKM1; PRKM2; P42MAPK; p41mapk",null,"ERK1/2 activation→Ser15 p.P53→ dissociation of p53 from Mdm2","A, B","down"]
["NQO2","NAD(P)H dehydrogenase, quinone 2","QR2; DHQV; DIA6; NMOR2",null,"protects p53 against 20s proteasomal degradation leading to stabilization and activation of p53","A, B","down"]
["VRK1","vaccinia related kinase 1","MGC117401; MGC138280; MGC142070",null,"stability and nuclear localization↑","B","down"]
["GADD45A","growth arrest and DNA-damage-inducible, alpha","DDIT1; GADD45","→","stabilizes p53","B","down"]
["FTH1","ferritin, heavy polypeptide 1","FHC; FTH; PLIF; FTHL6; PIG15; MGC104426","┤","heavy subunit of ferritin, Ferritin stabilize p53","B","down"]
["BUB1B","budding uninhibited by benzimidazoles 1 homolog beta (yeast)","BUBR1; SSK1; Bub1A; MAD3L; hBUBR1; BUB1beta","┤","At mitotic spindle damage p53 expression and stability↑ via BUB1B-mediated phosp","B","down"]