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{"sheet":"post-translational modification","index":0,"n_rows":45,"n_cols":7,"rows_kept":45,"flags":["formulas_cached_only"]}
[null,null,"DEGs related to post-translational regulation of p53"]
[]
[1,"effect of p53 on this target","→","P53 is a transcriptional inducer of this gene"]
[null,null,"┤","P53 is a transcriptional repressor of this gene"]
[null,null,"→ ┤","P53 can be both a transcriptional inducer and a repressor of this gene"]
[2,"Description",null,"Short description of DEG function as arised from the literature"]
[3,"Leukemic subtype","A (CN-AML), B (APL)","DEG expressed in either of the subtypes or in both (in the same direction)"]
[4,"Differential expression",null,"up- gene expression is upregulated"]
[{"$nulls":3},"down- gene expression is downregulated"]
[5,null,null,"Genes that indicate activating p53 post-translational modifications"]
[{"$nulls":3},"Genes that indicate repressing p53 post-translational modifications"]
[{"$nulls":3},"Genes that appear more than once"]
[]
["Genes that indicate activating p53 post-translational modifications-"]
["Official Symbol","Official Full Name","Other Aliases:","effect of p53 on this target","Description","Leukemic subtype","Differential expression"]
[null,"Phoshporylation-"]
["LATS2","large tumor suppressor, homolog 2 (Drosophila)","FLJ13161, KPM","→","positive feedback loop with p53 that responds to cytoskeleton damage, prevents Mdm2-driven p53 degradation","A","up"]
["HIPK1","homeodomain interacting protein kinase 1","Myak; Nbak2; KIAA0630; MGC26642; MGC33446; MGC33548",null,"specific serine phosp.of p53, might induce Mdm2 transcription ","A, B","up"]
["AURKA","aurora kinase A","STK15; BTAK;AIK; ARK1; AURA; STK6; STK7; AURORA2; MGC34538","┤","Aurora A-mediated phosphorylation of Ser215 of p53 leads to inhibition of its transcriptional activation property ","A, B","down"]
[]
[null,"Acetylation-"]
["SOX4","SRY (sex determining region Y)-box 4","EVI16",null,"enhances p53 acetylation by interacting with p300/CBP and facilitating p300/CBP/p53 complex formation","A","up"]
["SKP2","S-phase kinase-associated protein 2 (p45)","FBL1; FLB1; FBXL1; MGC1366","┤","promots p300 degradation and suppresses p300-mediated acetylation of p53","B","down"]
["HDAC4","histone deacetylase 4","HD4; AHO3; BDMR; HDACA; HA6116; HDAC-A; KIAA0288",null,"Residues at the C-terminal of p53 are necessary for HDAC4 recruitment that otherwise are acetylated by PCAF, p300 and methylated by Set9","A","down"]
["BAG2","BCL2-associated athanogene 2","BAG-2; KIAA0576; MGC149462; dJ417I1.2",null,"abrogates deacetylation of p53 by SirT3","B","down"]
[]
[null,"Sumoylation-"]
["SUMO1","SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)","GMP1; PIC1; SMT3; UBL1; DAP-1; OFC10; SENP2; SMT3C; SMT3H3; SUMO-1",null,"sumoylation has an inhibitory effect on p53 binding to DNA","B","down"]
[]
["Genes that indicate repressing p53 post-translational modifications-"]
[null,"Phoshporylation-"]
["VRK1","vaccinia related kinase 1","MGC117401; MGC138280; MGC142070",null,"phosphorylate P53 at Thr18--> promotes the stability and nuclear accumulation of a transcriptionally active p53","B","down"]
["TP53RK","TP53 regulating kinase","PRPK; BUD32; Nori-2; Nori-2p; dJ101A2; C20orf64",null,"phosphorylate p53 at Ser15--> transcriptional activity of p53 ↑","B","down"]
[]
[null,"Acetylation-"]
["EP300","E1A binding protein p300","p300; KAT3B",null,"histone acetyltransferase, transcriptional co-activator after stress","A, B","down"]
["KAT2B","K(lysine) acetyltransferase 2B","PCAF;P; CAF; P/CAF","→","histone acetyl transferase, binds p300 and CBP","A, B","down"]
["CARM1","coactivator-associated arginine methyltransferase 1","PRMT4",null,"co-activator of p53, facilitates p53-mediated transcription together with p300 ","A, B","down"]
["MDM4","Mdm4 p53 binding protein homolog (mouse)","HDMX; MDMX; MRP1; MGC132766; DKFZp781B1423",null,"inhibits p53 tr. activity by inhibition of p300/CBP-mediated acetylation of p53","A, B","up"]
["TADA2B","transcriptional adaptor 2B","ADA2B; MGC21874; ADA2(beta);",null,"needed for optimal binding of  acetyltransferase GCN5L to p53","B","down"]
[]
["Genes which impact is not clear-"]
["EID1","EP300 interacting inhibitor of differentiation 1","CRI1; EID-1; RBP21; PTD014; C15orf3; PNAS-22; IRO45620; MGC138883; MGC138884",null,"Inhibitor of CBP/p300-dependent transcription in a tissue-specific manner","A","up"]
["EID1","EP300 interacting inhibitor of differentiation 1","CRI1; EID-1; RBP21; PTD014; C15orf3; PNAS-22; IRO45620; MGC138883; MGC138884",null,"Inhibitor of CBP/p300-dependent transcription in a tissue-specific manner","B","down"]
["CDC14B","CDC14 cell division cycle 14 homolog B (S. cerevisiae)","CDC14B3; Cdc14B1; Cdc14B2; hCDC14B",null,"interacts with and dephosphorylates p53. Outcome is not clear","B","down"]