{"text_format":"3","workbook":"xls","n_sheets":1,"sheets":["cell cycle genes"],"read":"whole","date_system":"1900","formulas":"cached_only"}

{"sheet":"cell cycle genes","index":0,"n_rows":94,"n_cols":7,"rows_kept":94,"flags":["formulas_cached_only"]}
[null,null,"DEGs related to cell cycle"]
[]
[1,"effect of p53 on this target","→","P53 is a transcriptional inducer of this gene"]
[null,null,"┤","P53 is a transcriptional repressor of this gene"]
[null,null,"→ ┤","P53 can be both a transcriptional inducer and a repressor of this gene"]
[2,"Description",null,"Short description of DEG function as arised from the literature"]
[3,"Leukemic subtype","A (CN-AML), B (APL)","DEG expressed in either of the subtypes or in both (in the same direction)"]
[4,"Differential expression",null,"up- gene expression is upregulated"]
[{"$nulls":3},"down- gene expression is downregulated"]
[5,null,null,"Genes that suggest stimulation of cell cycle arrest"]
[{"$nulls":3},"Genes that suggest inhibition of cell cycle arrest"]
[{"$nulls":3},"Genes that appear more than once"]
[]
["DEGs that suggest stimulation of cell cycle arrest via induction by p53-"]
["Official Symbol","Official Full Name","Other Aliases:","effect of p53 on this target ","Description","Leukemic subtype","Differential expression"]
["EGR1","early growth response 1","TIS8; AT225; G0S30; NGFI-A; ZNF225; KROX-24; ZIF-268","→","p53-target gene,anti-proliferative ","A","up"]
["ZMAT3","zinc finger, matrin type 3","WIG1; WIG-1; PAG608; FLJ12296; MGC10613","→","Overexpression of human wig-1 inhibits cell growth","A","up"]
["PLAGL1","pleiomorphic adenoma gene-like 1","ZAC; LOT1; ZAC1; MGC126275; MGC126276; DKFZp781P1017","→","enhances expression of p21Cip1 and p57Kip2à inhibit cell proliferation. ","A","up"]
["SIAH1","seven in absentia homolog 1 (Drosophila)","Siah-1; hSIAH1; HUMSIAH; Siah-1a; FLJ08065","→","induction of cell cycle arrest","B","up"]
["LATS2","large tumor suppressor, homolog 2 (Drosophila)","FLJ13161, KPM","→","mediator of G1/S, G2/M and the postmitotic checkpoint, activated by p53 in G2/M ","A, B","up"]
["CCNA1","cyclin A1",null,"→","S and G2/M arrest in some cancers, high in AML/APL= better prognosis. ","B","up"]
[]
["DEGs that suggest stimulation of cell cycle arrest via repression by p53-"]
["CDC25A","cell division cycle 25 homolog A (S. pombe)","CDC25A2","┤","activate the G1/S cyclin-dependent kinases CDK4 and CDK2, also G2/M","A","down"]
["E2F8","E2F transcription factor 8","FLJ23311","┤","Expression of E2F8 is being induced at the G1/S transition","A, B","down"]
["RRM2","ribonucleotide reductase M2 polypeptide","p53R2 ; R2; RR2M","┤→","DNA synthesis and cell proliferation, expressed during the late G1/early S phase, and degraded in late S phase.  ","A,B","down"]
["TOP2A","topoisomerase (DNA) II alpha 170kDa","TOP2; TP2A","┤","S phase mainly-markely upregulated in proliferating cells, inhibited by Rb\nduring cell cycle","A,B","down"]
["HMMR","hyaluronan-mediated motility receptor (RHAMM)","CD168; IHABP; RHAMM; MGC119494; MGC119495","┤","participates in the control of mitotic spindle stability and integrity, mRNA highly expressed in S and G(2)/M and protein in S","A,B","down"]
["SKP2","S-phase kinase-associated protein 2 (p45)","FBL1; FLB1; FBXL1; MGC1366"," ┤","forms a stable complex with the cyclin A-CDK2 S-phase kinase. It specifically recognizes and promotes the degradation of p27 predominantly in S, G2, and the initial part of the M phase","B","down"]
["ECT2","epithelial cell transforming sequence 2 oncogene","ARHGEF31; FLJ10461; MGC138291","┤","elevated in S and G2/ M , knockdown triggers cell cycle arrest in G1.","A","down"]
["GTSE1","G-2 and S-phase expressed 1","B99","┤→","Accumulates at S and G2 phases (can be p53-dep and indep)","A, B","down"]
["CCNA2","cyclin A2","CCN1; CCNA","┤","promotes both cell cycle G1/S and G2/M transitions","A, B","down"]
["CDC2","cell division cycle 2, G1 to S and G2 to M","CDK1; CDC28A; MGC111195; DKFZp686L20222","┤","essential for G1/S and G2/M phase transitions","B","down"]
["CCNB1","cyclin B1","CCNB","┤","G2/M phase","A, B","down"]
["CCNB2","cyclin B2","HsT17299","┤","G2/M phase","A, B","down"]
["FOXM1","forkhead box M1","MPP2; TGT3; HFH11; HNF-3; INS-1; MPP-2; PIG29; FKHL16; FOXM1B; HFH-11; TRIDENT; MPHOSPH2","┤","transcription factor that regulates many G2/M-specific genes , p53 is a  repressor after DDR","A","down"]
["BIRC5","baculoviral IAP repeat-containing 5","Survivin; API4; EPR-1","┤","key regulator of mitosis, expressed only in the G2-M phase","A, B","down"]
["CDC20","cell division cycle 20 homolog (S. cerevisiae)","CDC20A; p55CDC; MGC102824; bA276H19.3","┤","M phase-Promotes entry into anaphase","A, B","down"]
["AURKA","aurora kinase A","STK15; BTAK;AIK; ARK1; AURA; STK6; STK7; AURORA2; MGC34538","┤","M phase-bipolar spindle formation and centrosome maturation. mRNA and protein levels peak in G2/M phase. Also important for G1/S.","A, B","down"]
["AURKB","aurora kinase B","AIK2; AIM1; ARK2; AurB; IPL1; STK5; AIM-1; STK12","┤","M phase-coordination and completion of mitosis","A","down"]
["DLGAP5","discs, large (Drosophila) homolog-associated protein 5","DLG7; HURP; KIAA0008","┤","G2/M, knockdown of HURP inhibits the proliferation ","A, B","down"]
["CENPA","centromere protein A","CENP-A","┤","M phase-assembly of active kinetochores","A, B","down"]
["MAD2L1","MAD2 mitotic arrest deficient-like 1 (yeast)","MAD2; HSMAD2"," ┤","component of the mitotic spindle assembly checkpoint , P53 Represses Mad2 expression by induction of P21 ","B","down"]
["BUB1","budding uninhibited by benzimidazoles 1 homolog (yeast)","BUB1A; BUB1L; hBUB1","┤","kinase involved in spindle checkpoint function ","B","down"]
["BUB1B","budding uninhibited by benzimidazoles 1 homolog beta (yeast)","BUBR1; SSK1; Bub1A; MAD3L; hBUBR1; BUB1beta","┤","delaying the onset of anaphase and ensuring proper chromosome segregation","B","down"]
["TTK","TTK protein kinase","MPS1; ESK; PYT; CT96; MPS1L1; FLJ38280","┤","M phase-spindle checkpoint kinase , activates postmitotic checkpoint","A, B","down"]
["PTTG1","pituitary tumor-transforming 1","Securin; EAP1; PTTG; HPTTG; TUTR1; MGC126883; MGC138276, ","┤","M-phase- anaphase-promoting complex (APC) substrate","A, B","down"]
["PRC1","protein regulator of cytokinesis 1","ASE1; MGC1671; MGC3669","┤","M phase","A","down"]
[]
["Other DEGs that suggest stimulation of cell cycle arrest-"]
["SOX4","SRY (sex determining region Y)-box 4","EVI16",null,"transcription regulator, promotes p53-dependent cell cycle arrest ","A","up"]
["ZNF148","zinc finger protein 148","ZBP-89;BERF-1; BFCOL1; ZFP148; pHZ-52; HT-BETA",null,"binds p53 and Mdm2→ nuclear retention of p53 →cell cycle arrest","A","up"]
["CEBPA","CCAAT/enhancer binding protein (C/EBP), alpha","CEBP; C/EBP-alpha",null,"Tr.f. interact with CDK2 and CDK4, thereby inhibiting these kinases and causing growth arrest in cultured cells (G1/S arrest),  ","B","up"]
["CCNE1","cyclin E1",null,null,"regulatory subunit of CDK2, late G1/S","A","down"]
["FHL2","four and a half LIM domains 2","DRAL; AAG11; SLIM3",null,"Positively regulate cell growth and tissue homeostasis,  cyclin D1 expression","A, B","down"]
["E2F2","E2F transcription factor 2","E2F-2",null,"E2F activator, promotes proliferation (amoung others)","A","down"]
["CDH1","cadherin 1, type 1, E-cadherin (epithelial)","UVO; CDHE; ECAD; LCAM; Arc-1; CD324",null,"Cdh1 plays an essential role from late mitosis to the G1/S transition. depletion of Cdh1 can activate the p53/p21 pathway in G1 phase","A","down"]
["ASPM","asp (abnormal spindle) homolog, microcephaly associated (Drosophila)","ASP; MCPH5; Calmbp1; FLJ10517; FLJ10549; FLJ43117; DKFZp686N06184",null,"M phase-mitotic spindle regulation,  negative p53 modulator= cell cycle arrest↓","A, B","down"]
["ANLN","anillin, actin binding protein","scra; Scraps; DKFZp779A055",null,"proliferation marker whose mRNA correlates with Ki67","B","down"]
["PCNA","proliferating cell nuclear antigen","MGC8367","→ ┤","involved in DNA proliferation and in DNA repair, marker of proliferation","B","down"]
["CDC14B","CDC14 cell division cycle 14 homolog B (S. cerevisiae)","CDC14B3; Cdc14B1; Cdc14B2; hCDC14B",null,"involved in  initiation of DNA replication","B","down"]
[]
["DEGs that suggest inhibition of cell cycle arrest since no induction by p53-"]
["PADI4","peptidyl arginine deiminase, type IV","PAD4; PAD; PDI4; PDI5; PADI5","→","knockdown of PADI4 attenuated p53-mediated growth-inhibitory activity.","A, B","down"]
["BID","BH3 interacting domain death agonist","FP497; MGC15319; MGC42355","→","intra-S phase checkpoint after replicative stress in response to DNA-damaging agents ","A, B","down"]
["BTG3","BTG family, member 3","ANA; TOB5; TOFA; TOB55; MGC8928","→","Anti-proliferative,blocks G2/M-phase progression following DNA damage","A, B","down"]
["RPS27L","ribosomal protein S27-like",null,"→","facilitates p21-mediated cell cycle arrest","B","down"]
["GADD45A","growth arrest and DNA-damage-inducible, alpha","DDIT1; GADD45","→","mediate G2/M arrest by wt p53","B","down"]
[]
["Other DEGs that suggest inhibition of cell cycle arrest-"]
["KLF4","Kruppel-like factor 4 (gut)","EZF; GKLF",null,"an essential positive mediator of p53 in the transcriptional induction of p21→G1/S and G2/M arrest","A, B","down"]
["SP3","Sp3 transcription factor","SPR-2; DKFZp686O1631",null,"co-operate functionally with p53 for the synergistic transactivation of the p21Cip1 promoter","A, B","down"]
["GADD45G","growth arrest and DNA-damage-inducible, gamma","CR6; DDIT2; GRP17; GADD45gamma",null,"cdc2/cyclinB1 kinase inhibitor (S and G2/M)","A, B","down"]
["SERPINB2","serpin peptidase inhibitor, clade B (ovalbumin), member 2","PAI-2; PAI; PAI2; PLANH2; HsT1201","┤","overexpression of PAI-2 resulted in the retardation of cell growth, with the increase of Rb and p53","A","down"]
["MXD1","MAX dimerization protein 1","MAD; MAD1; bHLHc58; MGC104659",null,"G1/S arrest induction and  regulates cell cycle exit during a late stage of granulocyte differentiation","A","down"]
["CDKN1B","cyclin-dependent kinase inhibitor 1B (p27, Kip1)","P27KIP1; KIP1; MEN4; CDKN4; MEN1B; ",null,"Inhibits cell cycle in G1. P53-independent.","B","down"]
["CCNG2","cyclin G2",null,null,"repressed by mitogenic signals and induced by DDR, induces p53-dependent G1/S and G2/M arrest","B","down"]
[]
["DEGs that suggest induction of proliferation-"]
["CCND2","cyclin D2","KIAK0002; MGC102758",null,"cell cycle G1 phase progression and G1/S transition","A, B","up"]
["CDK6","cyclin-dependent kinase 6","PLSTIRE; MGC59692",null,"cell cycle G1 phase progression and G1/S transition","A, B","up"]
["ELK3","ELK3, ETS-domain protein (SRF accessory protein 2)","ERP; NET; SAP2",null,"represses EGR-1 gene, that is anti-proliferative","A","up"]
["NAP1L1","nucleosome assembly protein 1-like 1","NRP; NAP1; NAP1L; MGC8688; FLJ16112; MGC23410",null,"participates in DNA replication and thereby plays an important role in the process of cell proliferation","A","up"]
["BTG1","B-cell translocation gene 1, anti-proliferative","involved in a t(8;12) in a case of B-CLL",null,"anti-proliferative, high in quiscent cells, high in AML/APL- complete remission","A, B","down"]
[]
["Genes which impact is not clear-"]
["BCL6","B-cell CLL/lymphoma 6","BCL5; LAZ3; BCL6A; ZNF51; ZBTB27","→","context-related","A, B","down"]
["C13orf15","chromosome 13 open reading frame 15","RGC32; RGC-32; KIAA0564; MGC87338; bA157L14.2","→","Concentrate at the centrosome during mitosis, can both activate or suppress cell cycle progression, Induced by p53 in response to DNA damage","A, B","down"]
["HDAC4","histone deacetylase 4","HD4; AHO3; BDMR; HDACA; HA6116; HDAC-A; KIAA0288",null,"needed for repression of G2/M promotors together with p53/PCAF/P300","A","down"]
["WT1","Wilms tumor 1","GUD; WAGR; WT33; WIT-2",null,"WT1 protects p53 from degradation, inhibited p53-mediated apoptosis, but did not affect p53-mediated cell cycle arrest","A","up"]
["WTAP","Wilms tumor 1 associated protein","MGC3925; KIAA0105; DKFZp686F20131",null,"regulates G2/M transition through stabilization of cyclin A2 mRNA- seems to be not functional here","A","up"]
["BCL2L1","BCL2-like 1","bcl-xL; BCLX; BCL2L; Bcl-X; bcl-xS; BCL-XL/S; DKFZp781P2092",null,"binds and inhibits cdk1 (cdc2) during the G2/M cell-cycle checkpoint, and its overexpression stabilizes a G2/M-arrest senescence program in surviving cells after DNA damage","B","up"]
["EID1","EP300 interacting inhibitor of differentiation 1","CRI1; EID-1; RBP21; PTD014; C15orf3; PNAS-22; IRO45620; MGC138883; MGC138884",null,"is rapidly degraded by the proteasome as cells exit the cell cycle","A","up"]
["EID1","EP300 interacting inhibitor of differentiation 1","CRI1; EID-1; RBP21; PTD014; C15orf3; PNAS-22; IRO45620; MGC138883; MGC138884",null,"is rapidly degraded by the proteasome as cells exit the cell cycle","B","down"]