{"text_format":"3","workbook":"xls","n_sheets":3,"sheets":["Sheet1","Sheet2","Sheet3"],"read":"whole","date_system":"1900","formulas":"cached_only"}

{"sheet":"Sheet1","index":0,"n_rows":29,"n_cols":6,"rows_kept":29,"merged":[[0,0,0,5],[28,0,28,5]],"flags":["formulas_cached_only"]}
["Table S4: Predicted miRNA Targets of Key Genes (MMP3, CYP3A4, CYP3A43) from miRWalk Database Analysis."]
["miRNA ID","Target Gene","Binding Probability (BindingP)","Binding Energy (kcal/mol)","PhyloP Stem","PhyloP Flank"]
["hsa-miR-3135b","CYP3A4",1,-30.7,0.75,2.05]
["hsa-miR-3135b","MMP3",1,-24.1,5.078,4.955]
["hsa-miR-3677-5p","CYP3A4",1,-22.7,2.85,1.826]
["hsa-miR-3677-5p","MMP3",1,-22.1,5.24,4.838]
["hsa-miR-4430","CYP3A4",1,-24,1.068,2.368]
["hsa-miR-4430","MMP3",1,-21.5,1.216,2.133]
["hsa-miR-4436a","CYP3A4",1,-19.6,1.521,2.556]
["hsa-miR-4436a","MMP3",1,-24.7,1.827,2.408]
["hsa-miR-5572","CYP3A4",1,-25.4,3.534,2.053]
["hsa-miR-5572","CYP3A43",1,-23.2,0.02,0.339]
["hsa-miR-5698","CYP3A4",0.974,-23.4,3.545,1.77]
["hsa-miR-5698","MMP3",1,-19.6,4.169,4.836]
["hsa-miR-6132","CYP3A4",1,-19.1,2.282,1.121]
["hsa-miR-6132","MMP3",1,-20.7,2.857,3.024]
["hsa-miR-6760-5p","CYP3A4",1,-20.8,1.521,2.556]
["hsa-miR-6760-5p","CYP3A43",1,-22.7,-0.735,0.041]
["hsa-miR-6829-5p","CYP3A4",1,-22.5,2.866,1.644]
["hsa-miR-6829-5p","MMP3",1,-21.2,5.016,4.953]
["hsa-miR-6857-5p","CYP3A4",1,-23.6,4.843,1.599]
["hsa-miR-6857-5p","CYP3A43",1,-22.9,0.101,0.344]
["hsa-miR-7107-5p","CYP3A4",1,-22.7,-0.145,1.837]
["hsa-miR-7107-5p","CYP3A43",1,-21.2,-0.096,0.181]
["hsa-miR-769-3p","CYP3A4",1,-22.8,1.89,2.782]
["hsa-miR-769-3p","CYP3A43",1,-20.1,0.18,0.39]
["hsa-miR-936","CYP3A4",1,-18.7,0.102,-0.114]
["hsa-miR-936","MMP3",1,-21.8,3.614,2.825]
["Note: The analysis was performed using the miRWalk database to predict miRNA targets. The results indicate that multiple miRNAs can co-regulate gene combinations, including those containing MMP3 and CYP3A4, as well as CYP3A43 and CYP3A4. Binding probability (BindingP) indicates the likelihood of a functional miRNA-mRNA interaction. Binding energy is given in kcal/mol, with lower values indicating more stable binding. PhyloP scores represent evolutionary conservation at the binding site (stem and flank regions), with higher absolute values indicating stronger conservation."]

{"sheet":"Sheet2","index":1,"n_rows":0,"n_cols":0,"rows_kept":0,"flags":["formulas_cached_only"]}

{"sheet":"Sheet3","index":2,"n_rows":0,"n_cols":0,"rows_kept":0,"flags":["formulas_cached_only"]}