Analysis Type: PANTHER Overrepresentation Test (Released 20181113) Annotation Version and Release Date: GO Ontology database Released 2018-11-15 Analyzed List: upload_1 (Homo sapiens) Reference List: measured_genes.txt (Homo sapiens) There are duplicate IDs in the file. The unique set of IDs will be used. Test Type: FISHER Correction: BONFERRONI Bonferroni count: 7931 GO biological process complete measured_genes.txt - REFLIST (15062) upload_1 (543) upload_1 (expected) upload_1 (over/under) upload_1 (fold Enrichment) upload_1 (P-value) regulation of tumor necrosis factor secretion (GO:1904467) 19 8 .68 + 11.68 2.00E-02 response to type I interferon (GO:0034340) 56 22 2.02 + 10.90 9.85E-11 type I interferon signaling pathway (GO:0060337) 51 20 1.84 + 10.88 1.64E-09 cellular response to type I interferon (GO:0071357) 51 20 1.84 + 10.88 1.64E-09 defense response to fungus (GO:0050832) 21 8 .76 + 10.57 3.64E-02 disruption of cells of other organism (GO:0044364) 27 9 .97 + 9.25 2.26E-02 killing of cells of other organism (GO:0031640) 27 9 .97 + 9.25 2.26E-02 negative regulation of viral genome replication (GO:0045071) 47 15 1.69 + 8.85 1.79E-05 antimicrobial humoral immune response mediated by antimicrobial peptide (GO:0061844) 36 11 1.30 + 8.48 3.62E-03 negative regulation of viral life cycle (GO:1903901) 62 16 2.24 + 7.16 6.87E-05 regulation of viral genome replication (GO:0045069) 82 21 2.96 + 7.10 3.64E-07 SRP-dependent cotranslational protein targeting to membrane (GO:0006614) 90 23 3.24 + 7.09 4.47E-08 defense response to virus (GO:0051607) 157 40 5.66 + 7.07 5.90E-16 cotranslational protein targeting to membrane (GO:0006613) 93 23 3.35 + 6.86 7.92E-08 antimicrobial humoral response (GO:0019730) 59 14 2.13 + 6.58 1.43E-03 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) 114 26 4.11 + 6.33 1.71E-08 protein targeting to ER (GO:0045047) 102 23 3.68 + 6.25 3.95E-07 negative regulation of viral process (GO:0048525) 76 17 2.74 + 6.20 1.48E-04 response to virus (GO:0009615) 230 50 8.29 + 6.03 4.78E-18 establishment of protein localization to endoplasmic reticulum (GO:0072599) 106 23 3.82 + 6.02 7.68E-07 regulation of viral life cycle (GO:1903900) 118 25 4.25 + 5.88 1.83E-07 defense response to other organism (GO:0098542) 306 62 11.03 + 5.62 1.06E-21 protein localization to endoplasmic reticulum (GO:0070972) 129 24 4.65 + 5.16 4.70E-06 protein targeting to membrane (GO:0006612) 144 26 5.19 + 5.01 1.59E-06 nuclear-transcribed mRNA catabolic process (GO:0000956) 186 32 6.71 + 4.77 3.89E-08 regulation of viral process (GO:0050792) 153 26 5.52 + 4.71 5.06E-06 translational initiation (GO:0006413) 137 23 4.94 + 4.66 6.08E-05 regulation of symbiosis, encompassing mutualism through parasitism (GO:0043903) 173 28 6.24 + 4.49 2.97E-06 defense response to bacterium (GO:0042742) 143 23 5.16 + 4.46 1.24E-04 mRNA catabolic process (GO:0006402) 201 32 7.25 + 4.42 2.36E-07 humoral immune response (GO:0006959) 131 20 4.72 + 4.23 2.28E-03 RNA catabolic process (GO:0006401) 230 34 8.29 + 4.10 3.42E-07 innate immune response (GO:0045087) 489 71 17.63 + 4.03 9.20E-18 negative regulation of multi-organism process (GO:0043901) 135 19 4.87 + 3.90 1.35E-02 response to other organism (GO:0051707) 655 87 23.61 + 3.68 3.30E-20 response to external biotic stimulus (GO:0043207) 655 87 23.61 + 3.68 3.30E-20 negative regulation of defense response (GO:0031348) 152 20 5.48 + 3.65 1.85E-02 response to biotic stimulus (GO:0009607) 679 87 24.48 + 3.55 2.99E-19 nucleobase-containing compound catabolic process (GO:0034655) 368 47 13.27 + 3.54 6.89E-09 establishment of protein localization to membrane (GO:0090150) 233 29 8.40 + 3.45 3.04E-04 immune effector process (GO:0002252) 822 100 29.63 + 3.37 3.45E-21 defense response (GO:0006952) 902 109 32.52 + 3.35 2.65E-23 heterocycle catabolic process (GO:0046700) 402 48 14.49 + 3.31 3.51E-08 regulation of multi-organism process (GO:0043900) 312 37 11.25 + 3.29 1.30E-05 neutrophil degranulation (GO:0043312) 439 52 15.83 + 3.29 5.61E-09 cellular nitrogen compound catabolic process (GO:0044270) 406 48 14.64 + 3.28 4.82E-08 aromatic compound catabolic process (GO:0019439) 415 49 14.96 + 3.28 2.99E-08 neutrophil activation involved in immune response (GO:0002283) 443 52 15.97 + 3.26 7.70E-09 neutrophil mediated immunity (GO:0002446) 448 52 16.15 + 3.22 1.14E-08 neutrophil activation (GO:0042119) 448 52 16.15 + 3.22 1.14E-08 granulocyte activation (GO:0036230) 453 52 16.33 + 3.18 1.67E-08 organic cyclic compound catabolic process (GO:1901361) 441 50 15.90 + 3.14 6.88E-08 leukocyte degranulation (GO:0043299) 459 52 16.55 + 3.14 2.63E-08 myeloid cell activation involved in immune response (GO:0002275) 472 53 17.02 + 3.11 2.19E-08 myeloid leukocyte mediated immunity (GO:0002444) 468 52 16.87 + 3.08 5.13E-08 myeloid leukocyte activation (GO:0002274) 513 56 18.49 + 3.03 1.43E-08 cytokine-mediated signaling pathway (GO:0019221) 477 52 17.20 + 3.02 9.81E-08 immune response (GO:0006955) 1226 132 44.20 + 2.99 7.98E-25 positive regulation of defense response (GO:0031349) 308 33 11.10 + 2.97 9.16E-04 leukocyte activation involved in immune response (GO:0002366) 544 58 19.61 + 2.96 1.35E-08 inflammatory response (GO:0006954) 357 38 12.87 + 2.95 1.16E-04 response to bacterium (GO:0009617) 433 46 15.61 + 2.95 3.47E-06 cell activation involved in immune response (GO:0002263) 547 58 19.72 + 2.94 1.66E-08 positive regulation of response to external stimulus (GO:0032103) 237 25 8.54 + 2.93 4.08E-02 regulation of inflammatory response (GO:0050727) 256 27 9.23 + 2.93 1.72E-02 leukocyte mediated immunity (GO:0002443) 562 59 20.26 + 2.91 1.54E-08 regulation of innate immune response (GO:0045088) 307 31 11.07 + 2.80 7.18E-03 regulation of defense response (GO:0031347) 540 53 19.47 + 2.72 2.15E-06 generation of precursor metabolites and energy (GO:0006091) 339 32 12.22 + 2.62 1.82E-02 positive regulation of cytokine production (GO:0001819) 346 32 12.47 + 2.57 3.73E-02 translation (GO:0006412) 359 33 12.94 + 2.55 2.77E-02 regulation of cytokine production (GO:0001817) 554 50 19.97 + 2.50 9.52E-05 regulated exocytosis (GO:0045055) 617 55 22.24 + 2.47 3.01E-05 cellular response to cytokine stimulus (GO:0071345) 763 68 27.51 + 2.47 2.95E-07 peptide biosynthetic process (GO:0043043) 373 33 13.45 + 2.45 4.93E-02 response to cytokine (GO:0034097) 835 73 30.10 + 2.43 1.31E-07 leukocyte activation (GO:0045321) 773 67 27.87 + 2.40 1.41E-06 regulation of response to external stimulus (GO:0032101) 595 51 21.45 + 2.38 4.88E-04 cell activation (GO:0001775) 887 72 31.98 + 2.25 3.86E-06 exocytosis (GO:0006887) 695 55 25.06 + 2.20 1.42E-03 response to external stimulus (GO:0009605) 1530 120 55.16 + 2.18 1.75E-11 immune system process (GO:0002376) 1955 153 70.48 + 2.17 3.90E-16 secretion by cell (GO:0032940) 833 64 30.03 + 2.13 3.82E-04 secretion (GO:0046903) 914 66 32.95 + 2.00 1.59E-03 organonitrogen compound biosynthetic process (GO:1901566) 1238 82 44.63 + 1.84 1.91E-03 multi-organism process (GO:0051704) 1831 121 66.01 + 1.83 1.07E-06 regulation of immune system process (GO:0002682) 1157 76 41.71 + 1.82 7.12E-03 response to stress (GO:0006950) 2692 163 97.05 + 1.68 1.29E-07 cellular response to organic substance (GO:0071310) 1810 107 65.25 + 1.64 3.98E-03 cellular response to chemical stimulus (GO:0070887) 2190 126 78.95 + 1.60 1.16E-03 positive regulation of response to stimulus (GO:0048584) 1765 101 63.63 + 1.59 4.43E-02 response to organic substance (GO:0010033) 2302 128 82.99 + 1.54 5.42E-03 response to chemical (GO:0042221) 3091 158 111.43 + 1.42 2.69E-02 transport (GO:0006810) 3625 183 130.68 + 1.40 5.77E-03 establishment of localization (GO:0051234) 3731 184 134.51 + 1.37 2.60E-02 negative regulation of biological process (GO:0048519) 4161 205 150.01 + 1.37 3.93E-03 response to stimulus (GO:0050896) 6037 284 217.64 + 1.30 1.43E-04 Unclassified (UNCLASSIFIED) 1754 52 63.23 - .82 0.00E00