Reference list | upload_1 Mapped IDs: 14997 out of 15062 | 636 out of 658 Unmapped IDs: 6702 | 91 Multiple mapping information: 944 | 23 Analysis Type: PANTHER Overrepresentation Test (Released 20181010) Annotation Version and Release Date: GO Ontology database Released 2018-09-06 Analyzed List: upload_1 (Homo sapiens) Reference List: measured_genes.txt (Homo sapiens) There are duplicate IDs in the file. The unique set of IDs will be used. Test Type: FISHER Correction: BONFERRONI Bonferroni count: 7833 GO biological process complete measured_genes.txt - REFLIST (15062) upload_1 (658) upload_1 (expected) upload_1 (over/under) upload_1 (fold Enrichment) upload_1 (P-value) macrophage activation (GO:0042116) 30 12 1.31 + 9.16 7.15E-04 T cell activation involved in immune response (GO:0002286) 39 12 1.70 + 7.04 7.26E-03 regulation of myeloid leukocyte mediated immunity (GO:0002886) 40 12 1.75 + 6.87 9.08E-03 regulation of leukocyte degranulation (GO:0043300) 37 11 1.62 + 6.81 2.73E-02 neutrophil degranulation (GO:0043312) 439 111 19.18 + 5.79 5.32E-42 neutrophil activation involved in immune response (GO:0002283) 443 112 19.35 + 5.79 2.01E-42 leukocyte degranulation (GO:0043299) 459 116 20.05 + 5.78 4.07E-44 neutrophil activation (GO:0042119) 448 113 19.57 + 5.77 9.18E-43 myeloid cell activation involved in immune response (GO:0002275) 471 118 20.58 + 5.73 1.22E-44 granulocyte chemotaxis (GO:0071621) 52 13 2.27 + 5.72 1.86E-02 granulocyte activation (GO:0036230) 453 113 19.79 + 5.71 2.34E-42 myeloid leukocyte activation (GO:0002274) 510 127 22.28 + 5.70 3.01E-48 myeloid leukocyte mediated immunity (GO:0002444) 468 116 20.45 + 5.67 2.19E-43 neutrophil mediated immunity (GO:0002446) 448 111 19.57 + 5.67 2.86E-41 regulation of interleukin-8 production (GO:0032677) 53 13 2.32 + 5.61 2.22E-02 regulation of toll-like receptor signaling pathway (GO:0034121) 55 13 2.40 + 5.41 3.16E-02 leukocyte activation involved in immune response (GO:0002366) 541 127 23.63 + 5.37 8.17E-46 cell activation involved in immune response (GO:0002263) 544 127 23.77 + 5.34 1.38E-45 cytokine production (GO:0001816) 126 29 5.50 + 5.27 7.23E-08 T cell differentiation (GO:0030217) 109 25 4.76 + 5.25 2.11E-06 granulocyte migration (GO:0097530) 62 14 2.71 + 5.17 2.15E-02 leukocyte mediated immunity (GO:0002443) 560 123 24.46 + 5.03 1.53E-41 defense response to bacterium (GO:0042742) 138 30 6.03 + 4.98 1.09E-07 Fc-gamma receptor signaling pathway (GO:0038094) 74 16 3.23 + 4.95 6.93E-03 leukocyte activation (GO:0045321) 765 162 33.42 + 4.85 4.81E-55 leukocyte chemotaxis (GO:0030595) 90 19 3.93 + 4.83 9.19E-04 myeloid leukocyte migration (GO:0097529) 81 17 3.54 + 4.80 4.56E-03 regulation of acute inflammatory response (GO:0002673) 72 15 3.15 + 4.77 2.27E-02 Fc receptor signaling pathway (GO:0038093) 122 25 5.33 + 4.69 1.60E-05 regulated exocytosis (GO:0045055) 615 126 26.87 + 4.69 6.86E-40 positive regulation of inflammatory response (GO:0050729) 104 21 4.54 + 4.62 3.89E-04 T cell activation (GO:0042110) 171 34 7.47 + 4.55 4.08E-08 adaptive immune response (GO:0002250) 225 44 9.83 + 4.48 4.72E-11 innate immune response-activating signal transduction (GO:0002758) 133 26 5.81 + 4.47 1.81E-05 immune effector process (GO:0002252) 809 156 35.34 + 4.41 5.45E-48 cell activation (GO:0001775) 878 168 38.36 + 4.38 6.44E-52 cell chemotaxis (GO:0060326) 126 24 5.50 + 4.36 1.17E-04 exocytosis (GO:0006887) 690 130 30.14 + 4.31 6.88E-38 pattern recognition receptor signaling pathway (GO:0002221) 92 17 4.02 + 4.23 2.12E-02 inflammatory response (GO:0006954) 349 64 15.25 + 4.20 4.19E-16 leukocyte migration (GO:0050900) 224 41 9.79 + 4.19 2.76E-09 lymphocyte differentiation (GO:0030098) 181 33 7.91 + 4.17 6.33E-07 myeloid leukocyte differentiation (GO:0002573) 88 16 3.84 + 4.16 4.97E-02 regulation of tumor necrosis factor superfamily cytokine production (GO:1903555) 105 19 4.59 + 4.14 7.32E-03 activation of innate immune response (GO:0002218) 150 27 6.55 + 4.12 4.27E-05 regulation of T cell differentiation (GO:0045580) 112 20 4.89 + 4.09 4.57E-03 leukocyte differentiation (GO:0002521) 258 46 11.27 + 4.08 2.23E-10 regulation of tumor necrosis factor production (GO:0032680) 101 18 4.41 + 4.08 1.71E-02 immune response (GO:0006955) 1209 215 52.82 + 4.07 1.64E-64 immune response-activating signal transduction (GO:0002757) 297 52 12.97 + 4.01 8.34E-12 positive regulation of leukocyte activation (GO:0002696) 265 46 11.58 + 3.97 5.25E-10 secretion by cell (GO:0032940) 825 143 36.04 + 3.97 1.44E-38 immune response-regulating signaling pathway (GO:0002764) 331 57 14.46 + 3.94 6.29E-13 positive regulation of cell activation (GO:0050867) 274 47 11.97 + 3.93 4.09E-10 regulation of inflammatory response (GO:0050727) 276 47 12.06 + 3.90 5.18E-10 humoral immune response (GO:0006959) 130 22 5.68 + 3.87 2.85E-03 lymphocyte activation (GO:0046649) 292 49 12.76 + 3.84 2.44E-10 immune response-activating cell surface receptor signaling pathway (GO:0002429) 222 37 9.70 + 3.82 4.43E-07 defense response to other organism (GO:0098542) 291 48 12.71 + 3.78 7.96E-10 activation of immune response (GO:0002253) 346 57 15.12 + 3.77 3.60E-12 immune response-regulating cell surface receptor signaling pathway (GO:0002768) 255 42 11.14 + 3.77 3.04E-08 positive regulation of innate immune response (GO:0045089) 213 35 9.31 + 3.76 2.08E-06 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains (GO:0002460) 116 19 5.07 + 3.75 2.71E-02 regulation of cytokine secretion (GO:0050707) 142 23 6.20 + 3.71 3.09E-03 secretion (GO:0046903) 908 147 39.67 + 3.71 1.01E-36 regulation of leukocyte mediated immunity (GO:0002703) 156 25 6.82 + 3.67 1.16E-03 regulation of lymphocyte differentiation (GO:0045619) 139 22 6.07 + 3.62 7.77E-03 positive regulation of T cell activation (GO:0050870) 171 27 7.47 + 3.61 4.85E-04 cellular response to molecule of bacterial origin (GO:0071219) 146 23 6.38 + 3.61 4.76E-03 positive regulation of immune response (GO:0050778) 517 81 22.59 + 3.59 2.17E-17 positive regulation of leukocyte cell-cell adhesion (GO:1903039) 179 28 7.82 + 3.58 3.30E-04 regulation of T cell activation (GO:0050863) 256 40 11.18 + 3.58 4.20E-07 regulation of leukocyte activation (GO:0002694) 411 64 17.95 + 3.56 5.90E-13 positive regulation of defense response (GO:0031349) 300 46 13.11 + 3.51 2.59E-08 regulation of ossification (GO:0030278) 137 21 5.98 + 3.51 2.15E-02 regulation of leukocyte differentiation (GO:1902105) 222 34 9.70 + 3.51 1.89E-05 response to bacterium (GO:0009617) 413 63 18.04 + 3.49 2.52E-12 positive regulation of immune system process (GO:0002684) 741 113 32.37 + 3.49 6.73E-25 regulation of innate immune response (GO:0045088) 302 46 13.19 + 3.49 3.18E-08 innate immune response (GO:0045087) 473 72 20.66 + 3.48 1.77E-14 phagocytosis (GO:0006909) 165 25 7.21 + 3.47 2.99E-03 regulation of cell activation (GO:0050865) 438 66 19.13 + 3.45 8.10E-13 positive regulation of immune effector process (GO:0002699) 167 25 7.30 + 3.43 3.65E-03 positive regulation of cell-cell adhesion (GO:0022409) 208 31 9.09 + 3.41 1.70E-04 defense response (GO:0006952) 886 132 38.71 + 3.41 5.14E-29 regulation of immune response (GO:0050776) 740 110 32.33 + 3.40 2.79E-23 positive regulation of lymphocyte activation (GO:0051251) 230 34 10.05 + 3.38 4.23E-05 positive regulation of cytokine production (GO:0001819) 334 48 14.59 + 3.29 6.82E-08 cellular response to biotic stimulus (GO:0071216) 165 23 7.21 + 3.19 3.08E-02 regulation of lymphocyte activation (GO:0051249) 346 48 15.12 + 3.18 2.07E-07 regulation of hemopoiesis (GO:1903706) 333 46 14.55 + 3.16 6.19E-07 regulation of immune effector process (GO:0002697) 312 43 13.63 + 3.15 2.79E-06 positive regulation of response to external stimulus (GO:0032103) 225 31 9.83 + 3.15 8.40E-04 response to molecule of bacterial origin (GO:0002237) 256 35 11.18 + 3.13 1.50E-04 regulation of defense response (GO:0031347) 557 76 24.33 + 3.12 4.67E-13 response to lipopolysaccharide (GO:0032496) 242 33 10.57 + 3.12 4.06E-04 chemotaxis (GO:0006935) 384 52 16.78 + 3.10 6.69E-08 immune system process (GO:0002376) 1921 260 83.92 + 3.10 8.27E-59 regulation of cytokine production (GO:0001817) 533 72 23.28 + 3.09 5.33E-12 taxis (GO:0042330) 386 52 16.86 + 3.08 7.96E-08 regulation of immune system process (GO:0002682) 1134 152 49.54 + 3.07 1.47E-29 regulation of leukocyte cell-cell adhesion (GO:1903037) 239 32 10.44 + 3.06 9.44E-04 response to other organism (GO:0051707) 633 82 27.65 + 2.97 3.81E-13 response to external biotic stimulus (GO:0043207) 633 82 27.65 + 2.97 3.81E-13 cytokine-mediated signaling pathway (GO:0019221) 479 61 20.93 + 2.92 1.04E-08 response to biotic stimulus (GO:0009607) 661 82 28.88 + 2.84 3.66E-12 regulation of cell-cell adhesion (GO:0022407) 315 38 13.76 + 2.76 7.39E-04 negative regulation of immune system process (GO:0002683) 336 40 14.68 + 2.73 4.68E-04 cellular response to cytokine stimulus (GO:0071345) 750 87 32.76 + 2.66 1.67E-11 positive regulation of cell adhesion (GO:0045785) 329 38 14.37 + 2.64 3.01E-03 response to cytokine (GO:0034097) 819 93 35.78 + 2.60 6.20E-12 hemopoiesis (GO:0030097) 451 51 19.70 + 2.59 3.54E-05 regulation of response to external stimulus (GO:0032101) 598 66 26.12 + 2.53 4.45E-07 regulation of endopeptidase activity (GO:0052548) 302 33 13.19 + 2.50 4.10E-02 vesicle-mediated transport (GO:0016192) 1535 166 67.06 + 2.48 8.54E-23 cell migration (GO:0016477) 639 69 27.92 + 2.47 4.79E-07 localization of cell (GO:0051674) 726 77 31.72 + 2.43 5.12E-08 cell motility (GO:0048870) 726 77 31.72 + 2.43 5.12E-08 locomotion (GO:0040011) 911 96 39.80 + 2.41 1.96E-10 hematopoietic or lymphoid organ development (GO:0048534) 488 51 21.32 + 2.39 5.09E-04 cell-cell adhesion (GO:0098609) 347 36 15.16 + 2.37 4.92E-02 immune system development (GO:0002520) 518 52 22.63 + 2.30 1.24E-03 cell surface receptor signaling pathway (GO:0007166) 1783 172 77.89 + 2.21 1.16E-18 response to external stimulus (GO:0009605) 1493 143 65.22 + 2.19 3.04E-14 regulation of cell adhesion (GO:0030155) 537 51 23.46 + 2.17 6.59E-03 cell adhesion (GO:0007155) 695 65 30.36 + 2.14 3.15E-04 biological adhesion (GO:0022610) 700 65 30.58 + 2.13 3.69E-04 import into cell (GO:0098657) 510 47 22.28 + 2.11 3.51E-02 regulation of secretion by cell (GO:1903530) 546 50 23.85 + 2.10 2.34E-02 movement of cell or subcellular component (GO:0006928) 1102 100 48.14 + 2.08 1.58E-07 regulation of secretion (GO:0051046) 591 53 25.82 + 2.05 2.05E-02 positive regulation of multicellular organismal process (GO:0051240) 1327 115 57.97 + 1.98 5.59E-08 positive regulation of response to stimulus (GO:0048584) 1758 145 76.80 + 1.89 2.14E-09 regulation of response to stress (GO:0080134) 1117 91 48.80 + 1.86 2.59E-04 cellular response to organic substance (GO:0071310) 1789 139 78.15 + 1.78 4.17E-07 signal transduction (GO:0007165) 3430 261 149.84 + 1.74 3.05E-17 signaling (GO:0023052) 3676 275 160.59 + 1.71 1.10E-17 regulation of multicellular organismal process (GO:0051239) 2351 175 102.71 + 1.70 1.83E-08 cell communication (GO:0007154) 3765 277 164.48 + 1.68 8.64E-17 response to stress (GO:0006950) 2675 195 116.86 + 1.67 3.60E-09 cellular response to chemical stimulus (GO:0070887) 2169 158 94.76 + 1.67 1.83E-06 regulation of response to stimulus (GO:0048583) 3236 232 141.37 + 1.64 2.09E-11 regulation of cell death (GO:0010941) 1356 97 59.24 + 1.64 2.73E-02 regulation of localization (GO:0032879) 2121 151 92.66 + 1.63 2.28E-05 regulation of transport (GO:0051049) 1421 101 62.08 + 1.63 2.24E-02 multi-organism process (GO:0051704) 1778 126 77.67 + 1.62 9.69E-04 response to organic substance (GO:0010033) 2277 161 99.47 + 1.62 8.38E-06 regulation of cell differentiation (GO:0045595) 1387 98 60.59 + 1.62 3.52E-02 transport (GO:0006810) 3606 252 157.53 + 1.60 1.07E-11 response to stimulus (GO:0050896) 6023 416 263.12 + 1.58 6.74E-28 establishment of localization (GO:0051234) 3707 254 161.94 + 1.57 8.51E-11 response to chemical (GO:0042221) 3064 209 133.85 + 1.56 1.43E-07 regulation of catalytic activity (GO:0050790) 1839 124 80.34 + 1.54 1.37E-02 localization (GO:0051179) 4509 297 196.98 + 1.51 8.37E-12 regulation of signaling (GO:0023051) 2810 184 122.76 + 1.50 1.17E-04 regulation of molecular function (GO:0065009) 2444 160 106.77 + 1.50 1.42E-03 regulation of cell communication (GO:0010646) 2783 182 121.58 + 1.50 1.43E-04 cellular response to stimulus (GO:0051716) 4721 308 206.24 + 1.49 4.72E-12 regulation of signal transduction (GO:0009966) 2491 159 108.82 + 1.46 9.03E-03 positive regulation of biological process (GO:0048518) 4678 289 204.36 + 1.41 1.06E-07 regulation of biological quality (GO:0065008) 3128 192 136.65 + 1.41 4.65E-03 positive regulation of cellular process (GO:0048522) 4181 253 182.65 + 1.39 5.88E-05 multicellular organismal process (GO:0032501) 4786 276 209.08 + 1.32 7.06E-04 developmental process (GO:0032502) 4217 240 184.22 + 1.30 3.20E-02 regulation of cellular process (GO:0050794) 8236 431 359.80 + 1.20 2.94E-04 biological regulation (GO:0065007) 9330 479 407.59 + 1.18 7.72E-05 regulation of biological process (GO:0050789) 8775 450 383.35 + 1.17 1.33E-03 cellular process (GO:0009987) 11652 563 509.03 + 1.11 2.16E-03 biological_process (GO:0008150) 13332 619 582.42 + 1.06 2.12E-02 cellular nitrogen compound metabolic process (GO:0034641) 4383 126 191.48 - .66 9.23E-05 macromolecule biosynthetic process (GO:0009059) 3009 84 131.45 - .64 1.79E-02 organic cyclic compound metabolic process (GO:1901360) 4192 116 183.13 - .63 1.93E-05 cellular aromatic compound metabolic process (GO:0006725) 4040 111 176.49 - .63 2.89E-05 nucleobase-containing compound metabolic process (GO:0006139) 3880 106 169.50 - .63 5.40E-05 cellular macromolecule biosynthetic process (GO:0034645) 2971 81 129.79 - .62 7.40E-03 heterocycle metabolic process (GO:0046483) 4012 109 175.27 - .62 1.95E-05 gene expression (GO:0010467) 3159 81 138.00 - .59 1.32E-04 RNA metabolic process (GO:0016070) 2879 73 125.77 - .58 4.41E-04 nucleic acid metabolic process (GO:0090304) 3337 78 145.78 - .54 2.17E-07 Unclassified (UNCLASSIFIED) 1730 39 75.58 - .52 0.00E00 RNA processing (GO:0006396) 763 6 33.33 - .18 1.24E-04