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["Past tobacco smoking"]
["MR results","method","nsnp","b","se","pval","lo_ci","up_ci","or","or_lci95","or_uci95"]
[null,"Inverse variance weighted (multiplicative random effects)",106,-0.301730202574865,0.279960678543846,0.281141222672305,-0.850453132520803,0.246992727371072,0.739537563306612,0.427221300216914,1.28016980254448]
[null,"MR Egger",106,-0.786252360666186,1.37955575985066,0.569953247902266,-3.49018164997348,1.91767692864111,0.455548832953499,0.0304953321917803,6.80513128698532]
[null,"Weighted median",106,-0.126808434158492,0.413522942632908,0.759106802230429,-0.937313401718992,0.683696533402009,0.880902407245674,0.391678706431636,1.98118773971866]
[null,"MR PRESSO",106,-0.3017302,0.2799607,0.2836111]
["Heterogeneity test",null,"Q","Q_df","Q_pval"]
[null,"MR Egger",105.183235904265,104,0.449099731697139]
[null,"Inverse variance weighted",105.313397313056,105,0.473044521678315]
["Pleiotropy test","method"]
[null,"MR Egger","egger_intercept","se","pval"]
[null,null,0.00929838704196654,0.0259192895569303,0.7205139235395]
[null,"MR PRESSO","Global Test`$Pvalue"]
[null,null,0.485]
["LDSC regression","Intercept (SE)","Heritability (se)","Rg (se)","P "]
[null,"0.0021(0.0034)","0.469(0.069)","-1.025(0.157)",0.701]
["Smoking initiation*（Suggestive)"]
["MR results","method","nsnp","b","se","pval","lo_ci","up_ci","or","or_lci95","or_uci95","Power"]
[null,"Inverse variance weighted (multiplicative random effects)",98,0.492776884147072,0.224111701734207,0.027892122904355,0.0535179487480261,0.932035819546119,1.63685527228406,1.05497592709475,2.5396742367217,{"v":0.42,"d":"42%"}]
[null,"MR Egger",98,0.582723538953244,0.474976582561083,0.219880146564723,-0.348230562866478,1.51367764077297,1.79090940612286,0.705936094799863,4.54340913372425]
[null,"Weighted median",98,0.519769549230732,0.311773143337359,0.0954865246912828,-0.091305811710491,1.13084491017195,1.68164006979384,0.91273854208011,3.09827315705491]
[null,"MR PRESSO",98,0.4927769,0.2241117,0.03026922]
["Heterogeneity test","method","Q","Q_df","Q_pval"]
[null,"MR Egger",107.311733882774,96,0.202137728152028]
[null,"Inverse variance weighted",107.865773604885,97,0.211794256672436]
["Pleiotropy test","method"]
[null,"MR Egger","egger_intercept","se","pval"]
[null,null,0.0199904805090611,0.0283949279763971,0.483127094549842]
[null,"MR PRESSO","Global Test`$Pvalue"]
[null,null,0.198]
["LDSC regression","Intercept (SE)","Heritability (se)","Rg (se)","P "]
[null,"-0.0035(0.0023)","0.284(0.051)","0.312(0.649)",0.63]
["Cigarettes per day"]
["MR results","method","nsnp","b","se","pval","lo_ci","up_ci","or","or_lci95","or_uci95"]
[null,"Inverse variance weighted (multiplicative random effects)",28,-0.0630252152053143,0.172783088084265,0.715286867734133,-0.401680067850474,0.275629637439845,0.938919798335156,0.669194808379249,1.31735987289089]
[null,"MR Egger",28,-0.303218124751137,0.305682950464288,0.330370791456159,-0.902356707661141,0.295920458158866,0.738438007195803,0.405612622080648,1.34436321945348]
[null,"Weighted median",28,-0.0894693589892764,0.248309292733178,0.718612197013534,-0.576155572746306,0.397216854767753,0.914416283334193,0.562054997955188,1.48767850525081]
[null,"MR PRESSO",28,-0.06302522,0.1722504,0.7172962]
["Heterogeneity test","method","Q","Q_df","Q_pval"]
[null,"MR Egger",25.9264958991598,26,0.467150912696845]
[null,"Inverse variance weighted",26.8337829607454,27,0.472790028059198]
["Pleiotropy test","method"]
[null,"MR Egger","egger_intercept","se","pval"]
[null,null,0.0191611513642223,0.0201163527599727,0.349607178753925]
[null,"MR PRESSO","Global Test`$Pvalue"]
[null,null,0.407]
["LDSC regression","Intercept (SE)","Heritability (se)","Rg (se)","P "]
[null,"-0.0051(0.0029)","0.011(0.031)","0.063(0.030)",0.094]
["Alcoholic drinks per week"]
["MR results","method","nsnp","b","se","pval","lo_ci","up_ci","or","or_lci95","or_uci95"]
[null,"Inverse variance weighted (multiplicative random effects)",39,0.582723538953244,0.44250636820263,0.187882069197119,-0.284588942723911,1.4500360206304,1.70090940612286,0.752323438792253,4.26326807800681]
[null,"MR Egger",39,1.27207091073594,0.777701516823428,0.110386594322908,-0.252224062237978,2.79636588370986,3.56823441109271,0.777070606382374,16.3849934715469]
[null,"Weighted median",39,0.857178537603042,0.741336028299566,0.247574084415942,-0.595840077864108,2.31019715307019,2.35650252197806,0.551099404938434,10.0764110545707]
[null,"MR PRESSO",39,0.5827235,0.4425064,0.1957688]
["Heterogeneity test","method","Q","Q_df","Q_pval"]
[null,"MR Egger",31.728987692528,37,0.71429379446917]
[null,"Inverse variance weighted",32.9820958870422,38,0.700431020134252]
["Pleiotropy test","method"]
[null,"MR Egger","egger_intercept","se","pval"]
[null,null,-0.0169862756031397,0.0151741328237778,0.270174222406925]
[null,"MR PRESSO","Global Test`$Pvalue"]
[null,null,0.742]
["LDSC regression","Intercept (SE)","Heritability (se)","Rg (se)","P "]
[null,"0.0044(0.0027)","0.250(0.145)","-0.103(0.033)",0.359]
["Coffee intake*（Suggestive)"]
["MR results","method","nsnp","b","se","pval","lo_ci","up_ci","or","or_lci95","or_uci95","Power"]
[null,"Inverse variance weighted (multiplicative random effects)",42,-1.02332544841292,0.514135869731793,0.046549156440712,-2.03103175308723,-0.015619143738602,0.359397791932166,0.131200085199329,0.984502202490771,{"v":0.43,"d":"43%"}]
[null,"MR Egger",42,-1.37119034251408,1.1228922625438,0.229188177005966,-3.57205917709993,0.829678492071763,0.253804665188332,0.0280979354435916,2.29258153862165]
[null,"Weighted median",42,-1.43989238215488,0.830807734542845,0.0830737259857026,-3.06827554185886,0.188490777549096,0.236953257709011,0.0465012752581301,1.20742594750875]
[null,"MR PRESSO",42,-1.023325,0.5141359,0.05324428]
["Heterogeneity test","method","Q","Q_df","Q_pval"]
[null,"MR Egger",36.1719173847666,40,0.643276395127666]
[null,"Inverse variance weighted",36.2976672762248,41,0.67944635607075]
["Pleiotropy test","method"]
[null,"MR Egger","egger_intercept","se","pval"]
[null,null,0.00643927736486147,0.0181586401720148,0.724742861314483]
[null,"MR PRESSO","Global Test`$Pvalue"]
[null,null,0.712]
["LDSC regression","Intercept (SE)","Heritability (se)","Rg (se)","P "]
[null,"-0.0045(0.0053)","0.369(0.176)","0.098(0.140)",0.524]
["Education level"]
["MR results","method","nsnp","b","se","pval","lo_ci","up_ci","or","or_lci95","or_uci95"]
[null,"Inverse variance weighted (multiplicative random effects)",457,-0.0391938429053031,0.20944492992802,0.851557160356147,-0.449705905564222,0.371318219753616,0.961564298662487,0.637815702090684,1.44964430544989]
[null,"MR Egger",457,-1.11349493665613,0.826842602150976,0.178752731807524,-2.73410643687204,0.507116563559785,0.328409183751567,0.0649520199110355,1.66049634976858]
[null,"Weighted median",457,-0.203831539425302,0.3106769470418,0.511767251113053,-0.81275835562723,0.405095276776626,0.815599756018626,0.443632680274718,1.49944535557146]
[null,"MR PRESSO",457,-0.03919384,0.2094449,0.8516404]
["Heterogeneity test","method","Q","Q_df","Q_pval"]
[null,"MR Egger",495.75844368806,455,0.0909853394942888]
[null,"Inverse variance weighted",497.723672463664,456,0.086362545081403]
["Pleiotropy test","method"]
[null,"MR Egger","egger_intercept","se","pval"]
[null,null,0.0147403853948538,0.0109756852123875,0.179940315275627]
[null,"MR PRESSO","Global Test`$Pvalue"]
[null,null,0.08]
["LDSC regression","Intercept (SE)","Heritability (se)","Rg (se)","P "]
[null,"0.0036(0.0042)","0.077(0.017)","-0.031(0.168)",0.074]
["Household income"]
["MR results","method","nsnp","b","se","pval","lo_ci","up_ci","or","or_lci95","or_uci95"]
[null,"Inverse variance weighted (multiplicative random effects)",155,4.57734721089829,1.18140626997983,0.00010684807016681,2.26179092173782,6.89290350005875,97.2560519001719,9.60026710705056,985.257964777076]
[null,"MR Egger",155,4.60567745887662,2.60429394165779,0.0789712026436708,-0.498738666772652,9.7100935845259,100.050740157318,0.607296179673523,16483.1443718427]
[null,"Weighted median",155,4.16439694402314,1.84876296295291,0.0242886998407369,0.540821536635423,7.78797235141085,64.3538617581482,1.71741720393317,2411.42310307729]
[null,"MR PRESSO",155,4.577347,1.181406,0.0001576747]
["Heterogeneity test","method","Q","Q_df","Q_pval"]
[null,"MR Egger",196.021023463431,153,0.0107852458865476]
[null,"Inverse variance weighted",196.021214682473,154,0.0124480978758866]
["Pleiotropy test","method"]
[null,"MR Egger","egger_intercept","se","pval"]
[null,null,-0.000144654713650975,0.0118405706190275,0.990268506006944]
[null,"MR PRESSO","Global Test`$Pvalue"]
[null,null,0.011]
["LDSC regression","Intercept (SE)","Heritability (se)","Rg (se)","P "]
[null,"0.0040(0.0019)","0.377(0.021)","-0.043(0.268)",0.874]
["Inflammatory bowel disease"]
["MR results","method","nsnp","b","se","pval","lo_ci","up_ci","or","or_lci95","or_uci95"]
[null,"Inverse variance weighted (multiplicative random effects)",181,-0.019869457,0.045036298,{"v":0.659077178,"d":"6.59E-01"},-0.1081406,0.068401687,0.98032664,0.897501399,1.070795346]
[null,"MR Egger",181,-0.151430336,0.122197142,0.216882798,-0.390936735,0.088076062,0.859477754,0.676422949,1.092071184]
[null,"Weighted median",181,-0.07786394,0.064570543,0.227866071,-0.204422204,0.048694324,0.925090286,0.815118153,1.049899373]
[null,"MR PRESSO",181,-0.01986946,0.0450363,{"v":0.6596067,"d":"6.60E-01"}]
["Heterogeneity test","method","Q","Q_df","Q_pval"]
[null,"MR Egger",205.012191153967,179,0.0888035298896569]
[null,"Inverse variance weighted",206.547978444389,180,0.0852626767392866]
["Pleiotropy test","method"]
[null,"MR Egger","egger_intercept","se","pval"]
[null,null,0.0140470657959981,0.0121306315041008,0.248413670565954]
[null,"MR PRESSO","Global Test`$Pvalue"]
[null,null,0.103]
["LDSC regression","Intercept (SE)","Heritability (se)","Rg (se)","P "]
[null,"0.0065(0.0039)","0.545(0.148)","-0.420(0.007)",0.604]
["Systemic lupus erythematosus"]
["MR results","method","nsnp","b","se","pval","lo_ci","up_ci","or","or_lci95","or_uci95"]
[null,"Inverse variance weighted (multiplicative random effects)",5,0.398568328528593,0.0988443228623049,{"v":5.52375032573495e-05,"d":"5.52E-05"},0.204833455718476,0.592303201338711,1.48969042293597,1.22732064470617,1.80814815244833]
[null,"MR Egger",5,-0.109347390143922,0.283112674885273,0.725088156127424,-0.664248232919056,0.445553452631213,0.896418956291851,0.51466028697359,1.56135409227836]
[null,"Weighted median",5,0.368012413759382,0.110016197973768,0.000822603759543401,0.152380665730797,0.583644161787967,1.44485997500662,1.16460347669712,1.79255891738942]
[null,"MR PRESSO",5,0.3985683,0.09884432,{"v":0.01570387,"d":"1.57E-02"}]
["Heterogeneity test","method","Q","Q_df","Q_pval"]
[null,"MR Egger",3.0620298896723,3,0.382159914991314]
[null,"Inverse variance weighted",6.61443996910138,4,0.157721051402945]
["Pleiotropy test","method"]
[null,"MR Egger","egger_intercept","se","pval"]
[null,null,0.240113852735726,0.128706284996394,0.158945626836276]
[null,"MR PRESSO","Global Test`$Pvalue"]
[null,null,0.233]
["LDSC regression","Intercept (SE)","Heritability (se)","Rg (se)","P "]
[null,"-0.0026(0.0030)","0.070(0.267)","0.886(0.917)",0.334]
[" Rheumatoid arthritis*"]
["MR results","method","nsnp","b","se","pval","lo_ci","up_ci","or","or_lci95","or_uci95","Power"]
[null,"Inverse variance weighted (multiplicative random effects)",46,0.482196413399791,0.0658866369073652,{"v":2.50614548584735e-13,"d":"2.51E-13"},0.353058605061355,0.611334221738226,1.61962787067927,1.42341456028689,1.8428885812102,{"v":0.54,"d":"54%"}]
[null,"MR Egger",46,0.390331363339811,0.110201335982165,0.000953531390728693,0.174336744814767,0.606325981864855,1.47747029226777,1.19045637834342,1.83368202669589]
[null,"Weighted median",46,0.31772579651154,0.0839931737696348,{"v":0.000155100590546544,"d":"1.55E-04"},0.153099175923056,0.482352417100024,1.37399945412555,1.16544055685436,1.61988055832968]
[null,"MR PRESSO",46,0.4821964,0.06588664,{"v":3.441531e-09,"d":"3.44E-09"}]
["Heterogeneity test","method","Q","Q_df","Q_pval"]
[null,"MR Egger",58.1812057293879,44,0.0744050030494611]
[null,"Inverse variance weighted",59.6098443662436,45,0.0710782859312517]
["Pleiotropy test","method"]
[null,"MR Egger","egger_intercept","se","pval"]
[null,null,0.0226904889511857,0.0218296955697361,0.304282096264829]
[null,"MR PRESSO","Global Test`$Pvalue"]
[null,null,0.081]
["LDSC regression","Intercept (SE)","Heritability (se)","Rg (se)","P "]
[null,"-0.0015(0.0028)","0.300(0.001)","0.234(0.587)",0.142]
["Cholelithiasis*（Suggestive)"]
["MR results","method","nsnp","b","se","pval","lo_ci","up_ci","or","or_lci95","or_uci95","Power"]
[null,"Inverse variance weighted (multiplicative random effects)",50,0.125797786478639,0.0525918931718414,{"v":0.0167585977781162,"d":"1.68E-02"},0.0227176758618294,0.228877897095448,1.13405282428057,1.0229776874802,1.25718852326741,{"v":0.2,"d":"20%"}]
[null,"MR Egger",50,0.204885285399589,0.0963341795976421,0.0386024188853419,0.0160702933882109,0.393700277410968,1.22738425799232,1.01620011504474,1.48245615648354]
[null,"Weighted median",50,0.19347531493972,0.0907989655664672,{"v":0.0331048244028814,"d":"3.31E-02"},0.0155093424294444,0.371441287449996,1.21345943186256,1.01563023646781,1.44982272081349]
[null,"MR PRESSO",50,0.1257978,0.05259189,{"v":0.02063996,"d":"2.06E-02"}]
["Heterogeneity test","method","Q","Q_df","Q_pval"]
[null,"MR Egger",40.1394675558048,48,0.782804660013704]
[null,"Inverse variance weighted",41.1837795931055,49,0.778635370867918]
["Pleiotropy test","method"]
[null,"MR Egger","egger_intercept","se","pval"]
[null,null,-0.016581631863045,0.0162260244838073,0.311943724738128]
[null,"MR PRESSO","Global Test`$Pvalue"]
[null,null,0.767]
["LDSC regression","Intercept (SE)","Heritability (se)","Rg (se)","P "]
[null,"-0.0007(0.0019)","0.016(0.158)","0.331(0.352)",0.271]
["Serum 25-Hydroxyvitamin D"]
["MR results","method","nsnp","b","se","pval","lo_ci","up_ci","or","or_lci95","or_uci95"]
[null,"Inverse variance weighted (multiplicative random effects)",173,-0.0746724813533461,0.181354639769663,{"v":0.680523851345731,"d":"6.81E-01"},-0.430127575301885,0.280782612595193,0.928047389383879,0.65042611112262,1.32416571569628]
[null,"MR Egger",173,-0.482571360576294,0.278708683536386,0.0851743043183944,-1.02884038030761,0.0636976591550217,0.617194320500403,0.357421193000567,1.06577012420567]
[null,"Weighted median",173,-0.342885384705501,0.269686356399476,{"v":0.203578272581685,"d":"2.04E-01"},-0.871470643248473,0.185699873837471,0.709719551614133,0.418335873810728,1.20406083598573]
[null,"MR PRESSO",173,-0.07467248,0.1813546,{"v":0.6810365,"d":"6.81E-01"}]
["Heterogeneity test","method","Q","Q_df","Q_pval"]
[null,"MR Egger",197.426419740261,171,0.0812098690983432]
[null,"Inverse variance weighted",201.667618725492,172,0.0604102964140917]
["Pleiotropy test","method"]
[null,"MR Egger","egger_intercept","se","pval"]
[null,null,0.0151282190608472,0.00789310826653281,0.0569517682592931]
[null,"MR PRESSO","Global Test`$Pvalue"]
[null,null,0.067]
["LDSC regression","Intercept (SE)","Heritability (se)","Rg (se)","P "]
[null,"0.0029(0.0045)","0.475(0.264)","-0.085(0.003)",0.15]
["Serum calcium levels"]
["MR results","method","nsnp","b","se","pval","lo_ci","up_ci","or","or_lci95","or_uci95"]
[null,"Inverse variance weighted (multiplicative random effects)",327,-0.0238388411075504,0.143615326379752,{"v":0.868164090598383,"d":"8.68E-01"},-0.305324880811865,0.257647198596764,0.976443059560428,0.736883936047879,1.29388225461571]
[null,"MR Egger",327,-0.25338917872192,0.263524250495322,0.336995421140951,-0.769896709692752,0.263118352248912,0.776165755840193,0.463060895543316,1.30098068383022]
[null,"Weighted median",327,-0.250616553299113,0.291413722916374,{"v":0.389787620799992,"d":"3.90E-01"},-0.821787450215206,0.320554343616979,0.778320758874708,0.439645108016132,1.37789137795449]
[null,"MR PRESSO",327,-0.02383884,0.1436153,{"v":0.868267,"d":"8.68E-01"}]
["Heterogeneity test","method","Q","Q_df","Q_pval"]
[null,"MR Egger",370.598986020151,325,0.0411940667723736]
[null,"Inverse variance weighted",371.829643872954,326,0.0406818303932726]
["Pleiotropy test","method"]
[null,"MR Egger","egger_intercept","se","pval"]
[null,null,0.00687302517928176,0.00661591176041387,0.299640769091067]
[null,"MR PRESSO","Global Test`$Pvalue"]
[null,null,0.043]
["LDSC regression","Intercept (SE)","Heritability (se)","Rg (se)","P "]
[null,"-0.0052(0.0021)","0.961(0.061)","0.372(0.580)",0.846]
["Testosterone"]
["MR results","method","nsnp","b","se","pval","lo_ci","up_ci","or","or_lci95","or_uci95"]
[null,"Inverse variance weighted (multiplicative random effects)",246,-0.0433137443468371,0.290563692318769,{"v":0.88149998726846,"d":"8.81E-01"},-0.612818581291624,0.52619109259795,0.957610897924947,0.541821546752244,1.69247354100508]
[null,"MR Egger",246,-0.197303620662216,0.535661564280804,0.71294181595729,-1.24720028665259,0.852593045328159,0.820941340715872,0.287308052081553,2.34572153482519]
[null,"Weighted median",246,-0.356319439176446,0.510487658097618,{"v":0.485178353194512,"d":"4.85E-01"},-1.35687524904778,0.644236370694884,0.700248897573115,0.257464032293598,1.90453211729861]
[null,"MR PRESSO",246,-0.04331374,0.2905637,{"v":0.8816226,"d":"8.82E-01"}]
["Heterogeneity test","method","Q","Q_df","Q_pval"]
[null,"MR Egger",265.1492542287,244,0.168272928795485]
[null,"Inverse variance weighted",265.276693163269,245,0.178313377211659]
["Pleiotropy test","method"]
[null,"MR Egger","egger_intercept","se","pval"]
[null,null,0.00263238236982756,0.00768684633452889,0.732304936139039]
[null,"MR PRESSO","Global Test`$Pvalue"]
[null,null,0.169]
["LDSC regression","Intercept (SE)","Heritability (se)","Rg (se)","P "]
[null,"0.0040(0.0027)","0.353(0.177)","-0.106(0.102)",0.114]
["C-reactive protein*"]
["MR results","method","nsnp","b","se","pval","lo_ci","up_ci","or","or_lci95","or_uci95","Power"]
[null,"Inverse variance weighted (multiplicative random effects)",390,0.334560696462241,0.124684332698213,{"v":0.00729079101809294,"d":"7.29E-03"},0.0901794043737426,0.578941988550739,1.39732639993849,1.0943706009669,1.78414978092427,{"v":0.46,"d":"46%"}]
[null,"MR Egger",390,0.523300203692769,0.2112244545235,0.013657102312548,0.109300272826708,0.937300134558829,1.68758785341567,1.11549725357128,2.55307913477901]
[null,"Weighted median",390,0.447893978665543,0.204375556453878,{"v":0.0284138801841319,"d":"2.84E-02"},0.0473178880159411,0.848470069315145,1.56501276211595,1.04845524746903,2.33607009121116]
[null,"MR PRESSO",390,0.3345607,0.1246843,{"v":0.007601963,"d":"7.60E-03"}]
["Heterogeneity test","method","Q","Q_df","Q_pval"]
[null,"MR Egger",430.81121850737,388,0.0658525353630802]
[null,"Inverse variance weighted",432.171434186739,389,0.0645517340014198]
["Pleiotropy test","method"]
[null,"MR Egger","egger_intercept","se","pval"]
[null,null,-0.00632873705974868,0.00571795592274553,0.269058313324116]
[null,"MR PRESSO","Global Test`$Pvalue"]
[null,null,0.052]
["LDSC regression","Intercept (SE)","Heritability (se)","Rg (se)","P "]
[null,"0.0056(0.0030)","0.048(0.034)","-0.190(0.270)",0.472]
[" Triglyceride"]
["MR results","method","nsnp","b","se","pval","lo_ci","up_ci","or","or_lci95","or_uci95"]
[null,"Inverse variance weighted (multiplicative random effects)",96,-0.0455512648626438,0.12223030394453,{"v":0.70939590929682,"d":"7.09E-01"},-0.285122660593922,0.194020130868634,0.955470619246348,0.75192201746134,1.21412072401502]
[null,"MR Egger",96,0.0544073389350028,0.200881995968577,0.787106170005956,-0.339321373163408,0.448136051033414,1.05591462970637,0.712253513139561,1.56539165431884]
[null,"Weighted median",96,-0.189778727226195,0.189898776619042,{"v":0.317616540591937,"d":"3.18E-01"},-0.561980329399517,0.182422874947128,0.827142137730885,0.570079001063997,1.20012158794324]
[null,"MR PRESSO",96,-0.04555126,0.1222303,{"v":0.7102261,"d":"7.10E-01"}]
["Heterogeneity test","method","Q","Q_df","Q_pval"]
[null,"MR Egger",102.199499651297,94,0.264426003261613]
[null,"Inverse variance weighted",102.628581494772,95,0.278483225870248]
["Pleiotropy test","method"]
[null,"MR Egger","egger_intercept","se","pval"]
[null,null,-0.00736116558306426,0.0117175543337528,0.531385261225296]
[null,"MR PRESSO","Global Test`$Pvalue"]
[null,null,0.278]
["LDSC regression","Intercept (SE)","Heritability (se)","Rg (se)","P "]
[null,"-0.0031(0.0038)","0.070(0.124)","0.470(0.020)",0.265]
[" HDL-C"]
["MR results","method","nsnp","b","se","pval","lo_ci","up_ci","or","or_lci95","or_uci95"]
[null,"Inverse variance weighted (multiplicative random effects)",129,-0.0919486661649158,0.120610480131616,{"v":0.445844873310811,"d":"4.46E-01"},-0.328345207222884,0.144447874893052,0.91215197260221,0.720114388104982,1.15540146796901]
[null,"MR Egger",129,-0.226122372531172,0.203324614557108,0.268185224639776,-0.624638617063103,0.172393872000759,0.797620488855097,0.535454897822183,1.18814571839572]
[null,"Weighted median",129,0.0319028544936393,0.195456053616405,{"v":0.870343135387492,"d":"8.70E-01"},-0.351191010594514,0.414996719581792,1.03241720574114,0.703849298341892,1.51436577293085]
[null,"MR PRESSO",129,-0.09194867,0.1206105,{"v":0.4472474,"d":"4.47E-01"}]
["Heterogeneity test","method","Q","Q_df","Q_pval"]
[null,"MR Egger",148.910127120846,127,0.0894591994665149]
[null,"Inverse variance weighted",149.699027677223,128,0.0921776664286315]
["Pleiotropy test","method"]
[null,"MR Egger","egger_intercept","se","pval"]
[null,null,0.00849436061038181,0.0103557085607991,0.413605489623218]
[null,"MR PRESSO","Global Test`$Pvalue"]
[null,null,0.108]
["LDSC regression","Intercept (SE)","Heritability (se)","Rg (se)","P "]
[null,"-0.0048(0.0042)","0.623(0.175)","0.133(0.202)",0.499]
[" LDL-C"]
["MR results","method","nsnp","b","se","pval","lo_ci","up_ci","or","or_lci95","or_uci95"]
[null,"Inverse variance weighted (multiplicative random effects)",68,-0.148009478268897,0.126524257079764,{"v":0.242077002343563,"d":"2.42E-01"},-0.395997022145234,0.0999780656074395,0.862422940626772,0.673008700056568,1.10514667708874]
[null,"MR Egger",68,0.0225756131380485,0.184249300126537,0.902853573351931,-0.338553015109964,0.383704241386062,1.02283237080583,0.712800989164347,1.46771128922643]
[null,"Weighted median",68,-0.175693014188332,0.184629671694858,{"v":0.341301479169034,"d":"3.41E-01"},-0.537567170710254,0.18618114233359,0.838875466679212,0.584167705334177,1.20464045199777]
[null,"MR PRESSO",68,-0.1480095,0.1265243,{"v":0.2462216,"d":"2.46E-01"}]
["Heterogeneity test","method","Q","Q_df","Q_pval"]
[null,"MR Egger",74.673130288898,66,0.217220569012107]
[null,"Inverse variance weighted",76.4937383903731,67,0.200090998240662]
["Pleiotropy test","method"]
[null,"MR Egger","egger_intercept","se","pval"]
[null,null,-0.0151049723154462,0.0119075361600638,0.209067646237825]
[null,"MR PRESSO","Global Test`$Pvalue"]
[null,null,0.202]
["LDSC regression","Intercept (SE)","Heritability (se)","Rg (se)","P "]
[null,"-0.0037(0.0023)","0.428(0.196)","0.400(0.480)",0.094]
[" Apolipoprotein A-I"]
["MR results","method","nsnp","b","se","pval","lo_ci","up_ci","or","or_lci95","or_uci95"]
[null,"Inverse variance weighted (multiplicative random effects)",102,-0.101330662902695,0.123028333839606,{"v":0.410145960928855,"d":"4.10E-01"},-0.342466197228323,0.139804871422932,0.903634185177016,0.710017119526491,1.15004936946462]
[null,"MR Egger",102,-0.0900730853401069,0.217572418407415,0.6797670811105,-0.516515025418641,0.336368854738427,0.913864392740526,0.596596051405734,1.39985527284531]
[null,"Weighted median",102,-0.0682357895183133,0.203477084700596,{"v":0.737362010337414,"d":"7.37E-01"},-0.467050875531481,0.330579296494854,0.934040210719027,0.626848198365872,1.39177414486375]
[null,"MR PRESSO",102,-0.1013307,0.1230283,{"v":0.4120866,"d":"4.12E-01"}]
["Heterogeneity test","method","Q","Q_df","Q_pval"]
[null,"MR Egger",101.545077025031,100,0.438095950481047]
[null,"Inverse variance weighted",101.54909222116,101,0.465943201146962]
["Pleiotropy test","method"]
[null,"MR Egger","egger_intercept","se","pval"]
[null,null,-0.000691156333486849,0.0109913831384413,0.949986263750556]
[null,"MR PRESSO","Global Test`$Pvalue"]
[null,null,0.5]
["LDSC regression","Intercept (SE)","Heritability (se)","Rg (se)","P "]
[null,"-0.0014(0.0023)","0.0031(0.0012)","0.175(0.268)",0.504]
[" Total cholesterol"]
["MR results","method","nsnp","b","se","pval","lo_ci","up_ci","or","or_lci95","or_uci95"]
[null,"Inverse variance weighted (multiplicative random effects)",82,-0.263361047894662,0.129518895111808,{"v":0.0420142110857991,"d":"4.20E-02"},-0.517218082313805,-0.00950401347551816,0.768464394766467,0.596176757849049,0.990541006922842]
[null,"MR Egger",82,0.0659380319698921,0.203864134122446,0.747205217008961,-0.333635670910102,0.465511734849886,1.06816052331159,0.716314708978722,1.59282908651704]
[null,"Weighted median",82,-0.303794787070348,0.197037699967513,{"v":0.123119659186263,"d":"1.23E-01"},-0.689988679006674,0.0823991048659786,0.73801230057826,0.501581747437528,1.08588910698481]
[null,"MR PRESSO",82,-0.263361,0.1295189,{"v":0.04528879,"d":"4.53E-02"}]
["Heterogeneity test","method","Q","Q_df","Q_pval"]
[null,"MR Egger",80.6794724604096,80,0.457686227523073]
[null,"Inverse variance weighted",84.9789987790413,81,0.359483040119386]
["Pleiotropy test","method"]
[null,"MR Egger","egger_intercept","se","pval"]
[null,null,-0.0239682278157595,0.0116081269629589,0.0421833547569165]
[null,"MR PRESSO","Global Test`$Pvalue"]
[null,null,0.366]
["LDSC regression","Intercept (SE)","Heritability (se)","Rg (se)","P "]
[null,"-0.0049(0.0030)","0.123(0.113)","0.021(0.170)",0.906]
["Fasting glucose"]
["MR results","method","nsnp","b","se","pval","lo_ci","up_ci","or","or_lci95","or_uci95"]
[null,"Inverse variance weighted (multiplicative random effects)",86,-0.0793168647370827,0.276857790034881,{"v":0.774503193183989,"d":"7.75E-01"},-0.621958133205449,0.463324403731284,0.923747175160786,0.53689210137223,1.58934884949244]
[null,"MR Egger",86,-0.469732403999848,0.501630183577737,0.351745664432851,-1.45292756381221,0.513462755812516,0.625169538769238,0.233884572834295,1.67106768722983]
[null,"Weighted median",86,0.200800318928061,0.440089407023981,{"v":0.648194649253083,"d":"6.48E-01"},-0.661774918838941,1.06337555669506,1.22238066117126,0.515934778967633,2.8961305609119]
[null,"MR PRESSO",86,-0.07931686,0.2465353,{"v":0.74845,"d":"7.48E-01"}]
["Heterogeneity test","method","Q","Q_df","Q_pval"]
[null,"MR Egger",66.5295025352278,84,0.919571423347553]
[null,"Inverse variance weighted",67.4005850816725,85,0.919847972547776]
["Pleiotropy test","method"]
[null,"MR Egger","egger_intercept","se","pval"]
[null,null,0.0110630958429648,0.0118535113208646,0.353330857898445]
[null,"MR PRESSO","Global Test`$Pvalue"]
[null,null,0.916]
["LDSC regression","Intercept (SE)","Heritability (se)","Rg (se)","P "]
[null,"-0.0038(0.0025)","0.045(0.034)","0.250(0.262)",0.338]
["Fasting insulin"]
["MR results","method","nsnp","b","se","pval","lo_ci","up_ci","or","or_lci95","or_uci95"]
[null,"Inverse variance weighted (multiplicative random effects)",43,0.610969742964364,0.539674795570334,{"v":0.257589351684252,"d":"2.58E-01"},-0.446792856353491,1.66873234228222,1.84221700983395,0.639676399453943,5.30543805308215]
[null,"MR Egger",43,1.83721058240745,1.63261879097205,0.267000090653552,-1.36272224789777,5.03714341271267,6.27899905987979,0.25596303284017,154.02938758969]
[null,"Weighted median",43,-0.114449971323403,0.785692336453883,{"v":0.884183745352268,"d":"8.84E-01"},-1.65440695077301,1.42550700812621,0.89185655570524,0.191205416312271,4.15996644496396]
[null,"MR PRESSO",43,0.6109697,0.4490872,{"v":0.1809383,"d":"1.81E-01"}]
["Heterogeneity test","method","Q","Q_df","Q_pval"]
[null,"MR Egger",28.4501492046569,41,0.931070278377641]
[null,"Inverse variance weighted",29.0834865883168,42,0.934743488425223]
["Pleiotropy test","method"]
[null,"MR Egger","egger_intercept","se","pval"]
[null,null,-0.0215500258806987,0.0270788511038472,0.43071748150681]
[null,"MR PRESSO","Global Test`$Pvalue"]
[null,null,0.92]
["LDSC regression","Intercept (SE)","Heritability (se)","Rg (se)","P "]
[null,"-0.0040(0.0011)","0.061(0.112)","0.204(0.807)",0.801]
["HbA1c"]
["MR results","method","nsnp","b","se","pval","lo_ci","up_ci","or","or_lci95","or_uci95"]
[null,"Inverse variance weighted (multiplicative random effects)",93,-0.595914782334888,0.448313570914153,{"v":0.183769941557183,"d":"1.84E-01"},-1.47460938132663,0.282779816656852,0.55105823688678,0.228868109744216,1.32681298753306]
[null,"MR Egger",93,-0.196928359272118,0.861167397385875,0.819633822966655,-1.88481645814843,1.4909597396042,0.821249466114745,0.151856928973656,4.44135601945934]
[null,"Weighted median",93,-0.930125385430176,0.636511982245717,{"v":0.143937256038455,"d":"1.44E-01"},-2.17768887063178,0.31743809977143,0.394504242186258,0.113303086369884,1.3736042158188]
[null,"MR PRESSO",93,-0.5959148,0.4483136,{"v":0.1870569,"d":"1.87E-01"}]
["Heterogeneity test","method","Q","Q_df","Q_pval"]
[null,"MR Egger",115.289315108559,91,0.043654272586415]
[null,"Inverse variance weighted",115.663439860038,92,0.0482363090418235]
["Pleiotropy test","method"]
[null,"MR Egger","egger_intercept","se","pval"]
[null,null,-0.00735929912577804,0.0135426005368911,0.588170471361167]
[null,"MR PRESSO","Global Test`$Pvalue"]
[null,null,0.053]
["LDSC regression","Intercept (SE)","Heritability (se)","Rg (se)","P "]
[null,"0.0048(0.0020)","0.024(0.087)","-0.130(0.129)",0.773]
["Type 2 diabetes "]
["MR results","method","nsnp","b","se","pval","lo_ci","up_ci","or","or_lci95","or_uci95"]
[null,"Inverse variance weighted (multiplicative random effects)",63,-0.022984896840061,0.077692994761834,{"v":0.767350295474334,"d":"7.67E-01"},-0.175263166573256,0.129293372893134,0.977277243636332,0.839236132808095,1.1380239405729]
[null,"MR Egger",63,0.189521131028251,0.171070858945095,0.272275152530332,-0.145777752504135,0.524820014560636,1.20867066417354,0.86434978141387,1.6901546177799]
[null,"Weighted median",63,-0.0493607287852607,0.114381002071278,{"v":0.666071000661202,"d":"6.66E-01"},-0.273547492844965,0.174826035274444,0.951837712500199,0.760676208820717,1.19103899981594]
[null,"MR PRESSO",63,-0.0229849,0.07769299,{"v":0.7683389,"d":"7.68E-01"}]
["Heterogeneity test","method","Q","Q_df","Q_pval"]
[null,"MR Egger",67.472085790954,61,0.265553874416402]
[null,"Inverse variance weighted",69.6141348842623,62,0.236701597134353]
["Pleiotropy test","method"]
[null,"MR Egger","egger_intercept","se","pval"]
[null,null,-0.0253765042204373,0.0182353555415489,0.169094581458148]
[null,"MR PRESSO","Global Test`$Pvalue"]
[null,null,0.266]
["LDSC regression","Intercept (SE)","Heritability (se)","Rg (se)","P "]
[null,"-0.0036(0.0009)","0.083(0.222)","0.018(0.157)",0.933]
["Body mass index "]
["MR results","method","nsnp","b","se","pval","lo_ci","up_ci","or","or_lci95","or_uci95"]
[null,"Inverse variance weighted (multiplicative random effects)",386,0.114678341447621,0.163660609479441,{"v":0.483485098076055,"d":"4.83E-01"},-0.206096453132084,0.435453136027326,1.12151263541672,0.813754583319227,1.54566329601358]
[null,"MR Egger",386,0.174885363506782,0.459700504471111,0.703834176530786,-0.726127625256596,1.07589835227016,1.19110966415062,0.483778740142033,2.93262624896762]
[null,"Weighted median",386,0.487780447398042,0.263353253178842,{"v":0.0639984431942293,"d":"6.40E-02"},-0.0283919288324885,1.00395282362857,1.6286972260016,0.972007334437583,2.72904798143337]
[null,"MR PRESSO",386,0.1146783,0.1636606,{"v":0.4839084,"d":"4.84E-01"}]
["Heterogeneity test","method","Q","Q_df","Q_pval"]
[null,"MR Egger",435.549094931788,384,0.0354085292943001]
[null,"Inverse variance weighted",435.571382936267,385,0.0381930020232097]
["Pleiotropy test","method"]
[null,"MR Egger","egger_intercept","se","pval"]
[null,null,-0.00115781141656246,0.00825952705411733,0.888592140073804]
[null,"MR PRESSO","Global Test`$Pvalue"]
[null,null,0.036]
["LDSC regression","Intercept (SE)","Heritability (se)","Rg (se)","P "]
[null,"-0.0048(0.0028)","0.480(0.054)","0.021(0.146)",0.884]
[" Whole body fat mass"]
["MR results","method","nsnp","b","se","pval","lo_ci","up_ci","or","or_lci95","or_uci95"]
[null,"Inverse variance weighted (multiplicative random effects)",253,0.340768134390777,0.180832922901807,{"v":0.0595059759408245,"d":"5.95E-02"},-0.0136643944967653,0.695200663278319,1.40602719371222,0.986428539564258,2.00411118511587]
[null,"MR Egger",253,0.0156253304798771,0.536679430868936,0.976796143986742,-1.03626635402324,1.06751701498299,1.01574804427092,0.354776823277953,2.90814963589622]
[null,"Weighted median",253,0.455949500033804,0.282944147327108,{"v":0.107082328147977,"d":"1.07E-01"},-0.0986210287273289,1.01052002879494,1.57767067043919,0.906086023539571,2.74702917791486]
[null,"MR PRESSO",253,0.3407681,0.1808329,{"v":0.06065693,"d":"6.07E-02"}]
["Heterogeneity test","method","Q","Q_df","Q_pval"]
[null,"MR Egger",278.036391051381,251,0.115964814346587]
[null,"Inverse variance weighted",278.495180845292,252,0.120871331420706]
["Pleiotropy test","method"]
[null,"MR Egger","egger_intercept","se","pval"]
[null,null,0.0070492952935631,0.0109534969076027,0.520444640289838]
[null,"MR PRESSO","Global Test`$Pvalue"]
[null,null,0.13]
["LDSC regression","Intercept (SE)","Heritability (se)","Rg (se)","P "]
[null,"-0.0050(0.0018)","0.730(0.073)","0.368(0.019)",0.28]
["Waist circumference"]
["MR results","method","nsnp","b","se","pval","lo_ci","up_ci","or","or_lci95","or_uci95"]
[null,"Inverse variance weighted (multiplicative random effects)",165,0.478865173968442,0.251668475858371,{"v":0.0570716276989511,"d":"5.71E-02"},-0.0144050387139644,0.972135386650848,1.61424147911347,0.985698217458557,2.64358350937162]
[null,"MR Egger",165,0.173339269257831,0.727538278233121,0.811982959552165,-1.25263575607909,1.59931429459475,1.1892695192343,0.285750634430892,4.94963726746108]
[null,"Weighted median",165,0.545525344761751,0.393171448361626,{"v":0.165289382000936,"d":"1.65E-01"},-0.225090694027035,1.31614138355054,1.72551463438272,0.798443801391806,3.72900478190059]
[null,"MR PRESSO",165,0.4788652,0.2516685,{"v":0.05882394,"d":"5.88E-02"}]
["Heterogeneity test","method","Q","Q_df","Q_pval"]
[null,"MR Egger",198.979041276334,163,0.028797284482562]
[null,"Inverse variance weighted",199.223746115369,164,0.0316505301882245]
["Pleiotropy test","method"]
[null,"MR Egger","egger_intercept","se","pval"]
[null,null,0.00624882317023171,0.0139568310442982,0.654946089705235]
[null,"MR PRESSO","Global Test`$Pvalue"]
[null,null,0.02]
["LDSC regression","Intercept (SE)","Heritability (se)","Rg (se)","P "]
[null,"-0.0049(0.0022)","0.700(0.114)","0.470(0.444)",0.29]
["Hip circumference"]
["MR results","method","nsnp","b","se","pval","lo_ci","up_ci","or","or_lci95","or_uci95"]
[null,"Inverse variance weighted (multiplicative random effects)",256,0.16652286982412,0.169502069072614,{"v":0.32589109720483,"d":"3.26E-01"},-0.165701185558204,0.498746925206443,1.18119054918159,0.847299381657221,1.64665659350185]
[null,"MR Egger",256,-0.184147521950782,0.491999637267815,0.708505407701929,-1.1484668109957,0.780171767094136,0.831813084086116,0.317122605736533,2.18184700283303]
[null,"Weighted median",256,0.294038488753258,0.265319000768615,{"v":0.267755968048851,"d":"2.68E-01"},-0.225986752753228,0.814063730259744,1.34183554825043,0.797728669304217,2.25706146441866]
[null,"MR PRESSO",256,0.1665229,0.1695021,{"v":0.3268223,"d":"3.27E-01"}]
["Heterogeneity test","method","Q","Q_df","Q_pval"]
[null,"MR Egger",263.13467798565,254,0.333589341604263]
[null,"Inverse variance weighted",263.731964147612,255,0.340252793508431]
["Pleiotropy test","method"]
[null,"MR Egger","egger_intercept","se","pval"]
[null,null,0.00797672729568758,0.0105052333411946,0.448371313484118]
[null,"MR PRESSO","Global Test`$Pvalue"]
[null,null,0.339]
["LDSC regression","Intercept (SE)","Heritability (se)","Rg (se)","P "]
[null,"-0.0025(0.0013)","0.593(0.160)","0.255(0.399)",0.523]
["Waist-to-hip ratio"]
["MR results","method","nsnp","b","se","pval","lo_ci","up_ci","or","or_lci95","or_uci95"]
[null,"Inverse variance weighted (multiplicative random effects)",41,0.334799583246395,0.307816826767045,{"v":0.276745901741399,"d":"2.77E-01"},-0.268521397217014,0.938120563709803,1.3976602426223,0.764509064268481,2.55517461480484]
[null,"MR Egger",41,-0.323858286809005,1.50216951991083,0.83042804762115,-3.26811054583423,2.62039397221622,0.723352743742304,0.0380783063620623,13.7411361446691]
[null,"Weighted median",41,0.350616921163973,0.44773529020668,{"v":0.433574403705646,"d":"4.34E-01"},-0.52694424764112,1.22817808996907,1.41994327149531,0.590406351589692,3.41500203857227]
[null,"MR PRESSO",41,0.3347996,0.3078168,{"v":0.2832564,"d":"2.83E-01"}]
["Heterogeneity test","method","Q","Q_df","Q_pval"]
[null,"MR Egger",43.1847245536626,39,0.297088373990617]
[null,"Inverse variance weighted",43.4071403601925,40,0.328256683843803]
["Pleiotropy test","method"]
[null,"MR Egger","egger_intercept","se","pval"]
[null,null,0.0190406914631657,0.042484710679864,0.656505114841246]
[null,"MR PRESSO","Global Test`$Pvalue"]
[null,null,0.347]
["LDSC regression","Intercept (SE)","Heritability (se)","Rg (se)","P "]
[null,"0.0052(0.0021)","0.150(0.033)","-0.070(0.200)",0.704]

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["Past tobacco smoking"]
["MR results","method","nsnp","b","se","pval","lo_ci","up_ci","or","or_lci95","or_uci95"]
[null,"Inverse variance weighted (multiplicative random effects)",39,-0.136583627238636,0.191997625317807,0.476847638732524,-0.512898972861537,0.239731718384265,0.872333366378598,0.598757279284789,1.27090814329036]
[null,"MR Egger",39,0.550983244075964,0.742661393779609,0.462829416661617,-0.904633087732069,2.006599575884,1.73495806673159,0.404690343717533,7.43798200289654]
[null,"Weighted median",39,0.0121378278003887,0.291361774913211,0.96677057270231,-0.558931251029505,0.583206906630283,1.01221179017685,0.571819869288443,1.79177528309389]
[null,"MR PRESSO",39,-0.1365836,0.1916412,0.4803821]
["Heterogeneity test",null,"Q","Q_df","Q_pval"]
[null,"MR Egger",36.94051612138,37,0.471822866858301]
[null,"Inverse variance weighted",37.8590394323323,38,0.475918301441616]
["Pleiotropy test","method"]
[null,"MR Egger","egger_intercept","se","pval"]
[null,null,-0.0140017919508431,0.0146096068471161,0.34408403405851]
[null,"MR PRESSO","Global Test`$Pvalue"]
[null,null,0.491]
["LDSC regression","Intercept (SE)","Heritability (se)","Rg (se)","P "]
[null,"0.0002(0.0011)","0.469(0.067)","-0.623(0.172)",0.288]
["Smoking initiation*（Suggestive)"]
["MR results","method","nsnp","b","se","pval","lo_ci","up_ci","or","or_lci95","or_uci95","Power"]
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[null,"MR Egger",41,0.185859440045898,0.163976212683795,0.257023786684852,-0.13553393681434,0.507252816906136,1.20425297873738,0.873249527118535,1.66072261336707]
[null,"Weighted median",41,0.0866719733038037,0.187461758870041,0.643834062599452,-0.280753074081477,0.454097020689084,1.09053889516919,0.7552147945653,1.57475077346886]
[null,"MR PRESSO",41,0.1545542,0.07621784,0.04927861]
["Heterogeneity test","method","Q","Q_df","Q_pval"]
[null,"MR Egger",16.3168162873354,39,0.999483612151587]
[null,"Inverse variance weighted",17.2867709045689,40,0.999345720486156]
["Pleiotropy test","method"]
[null,"MR Egger","egger_intercept","se","pval"]
[null,null,0.0292821881551992,0.020656557415323,0.164463385229516]
[null,"MR PRESSO","Global Test`$Pvalue"]
[null,null,0.998]
["LDSC regression","Intercept (SE)","Heritability (se)","Rg (se)","P "]
[null,"0.0045(0.0051)","0.284(0.051)","-0.372(0.679)",0.584]
["Cigarettes per day"]
["MR results","method","nsnp","b","se","pval","lo_ci","up_ci","or","or_lci95","or_uci95"]
[null,"Inverse variance weighted (multiplicative random effects)",10,0.188875163013407,0.134225138688475,0.159382342073483,-0.0742061088160052,0.451956434842819,1.20789015370354,0.928480306142036,1.57138348951773]
[null,"MR Egger",10,0.243538384360236,0.226438038637131,0.313505842683776,-0.200280171368541,0.687356940089013,1.27575528595132,0.818501400292967,1.98845298132683]
[null,"Weighted median",10,0.184859440045898,0.163976212683795,0.217023786684852,-0.13553393681434,0.507252816906136,1.20125297873738,0.863249527118535,1.6760722613367]
[null,"MR PRESSO",10,0.1888752,0.128931,0.1769794]
["Heterogeneity test","method","Q","Q_df","Q_pval"]
[null,"MR Egger",8.21050421528728,8,0.413182415530174]
[null,"Inverse variance weighted",8.30404734501671,9,0.503819752308184]
["Pleiotropy test","method"]
[null,"MR Egger","egger_intercept","se","pval"]
[null,null,-0.00463226395079781,0.0153436000837429,0.770426124937346]
[null,"MR PRESSO","Global Test`$Pvalue"]
[null,null,0.624]
["LDSC regression","Intercept (SE)","Heritability (se)","Rg (se)","P "]
[null,"-0.0008(0.0017)","0.147(0.039)","0.510(0.407)",0.461]
["Alcoholic drinks per week"]
["MR results","method","nsnp","b","se","pval","lo_ci","up_ci","or","or_lci95","or_uci95"]
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[null,"MR Egger",9,1.04035250458867,1.77037343240124,0.575228274671597,-2.42957942291776,4.5102844320951,2.83021450213064,0.0880738666438423,90.9476832720686]
[null,"Weighted median",9,0.156170741131036,0.655166688689705,0.81159572249919,-1.12795596870079,1.44029745096286,1.16902578683586,0.323694221795893,4.22195145376717]
[null,"MR PRESSO",9,0.1592126,0.2955891,0.6048029]
["Heterogeneity test","method","Q","Q_df","Q_pval"]
[null,"MR Egger",2.26461538468596,7,0.943755764242278]
[null,"Inverse variance weighted",2.5362174529033,8,0.9600206553083]
["Pleiotropy test","method"]
[null,"MR Egger","egger_intercept","se","pval"]
[null,null,-0.0125611521097373,0.0241025469987899,0.618335000429448]
[null,"MR PRESSO","Global Test`$Pvalue"]
[null,null,0.957]
["LDSC regression","Intercept (SE)","Heritability (se)","Rg (se)","P "]
[null,"0.0039(0.0013)","0.219(0.040)","-0.249(0.548)",0.649]
["Coffee intake"]
["MR results","method","nsnp","b","se","pval","lo_ci","up_ci","or","or_lci95","or_uci95"]
[null,"Inverse variance weighted (multiplicative random effects)",16,-0.214806957429707,0.384004981087177,0.575898407942372,-0.967456720360574,0.537842805501159,0.806697152039012,0.380048379321851,1.71230909146107]
[null,"MR Egger",16,0.139396318205244,0.813211309718205,0.866350687938546,-1.45449784884244,1.73329048525293,1.14957960906183,0.233517595595612,5.6592449669586]
[null,"Weighted median",16,-0.363555494314029,0.513237738405534,0.47872364921861,-1.36950146158888,0.642390472960818,0.695200146490422,0.254233673215861,1.90101978847605]
[null,"MR PRESSO",16,-0.214807,0.3405386,0.5376735]
["Heterogeneity test","method","Q","Q_df","Q_pval"]
[null,"MR Egger",11.5522626735667,14,0.642210320905569]
[null,"Inverse variance weighted",11.7964181171748,15,0.694368713114594]
["Pleiotropy test","method"]
[null,"MR Egger","egger_intercept","se","pval"]
[null,null,0.000547468808297608,0.0195668084135674,0.977970327802493]
[null,"MR PRESSO","Global Test`$Pvalue"]
[null,null,0.744]
["LDSC regression","Intercept (SE)","Heritability (se)","Rg (se)","P "]
[null,"-0.0047(0.0015)","0.036(0.076)","0.096(0.591)",0.871]
["Education level"]
["MR results","method","nsnp","b","se","pval","lo_ci","up_ci","or","or_lci95","or_uci95"]
[null,"Inverse variance weighted (multiplicative random effects)",228,-0.103526157212646,0.11394987033585,0.363601600800923,-0.326867903070912,0.11981558864562,0.901652437718851,0.721179002266264,1.12728894752844]
[null,"MR Egger",228,0.653161554424199,0.465641723266836,0.162074754145665,-0.259496223178799,1.5658193320272,1.9216064990171,0.771440121579886,4.78659514040117]
[null,"Weighted median",228,0.0136058629987934,0.221738088176814,0.951072457727479,-0.421000789827762,0.448212515825348,1.01369884396965,0.656389582974251,1.56551135624241]
[null,"MR PRESSO",228,-0.1035262,0.1139499,0.3645651,-0.326867903070912,0.11981558864562,0.901652437718851,0.721179002266264,1.12728894752844]
["Heterogeneity test","method","Q","Q_df","Q_pval"]
[null,"MR Egger",249.609640065647,226,0.134551363186109]
[null,"Inverse variance weighted",252.710508898716,227,0.116063220363124]
["Pleiotropy test","method"]
[null,"MR Egger","egger_intercept","se","pval"]
[null,null,-0.0105157654761528,0.0062758947455665,0.0952033705818289]
[null,"MR PRESSO","Global Test`$Pvalue"]
[null,null,0.115]
["LDSC regression","Intercept (SE)","Heritability (se)","Rg (se)","P "]
[null,"0.0007(0.0031)","0.213(0.271)","-0.341(0.049)",0.491]
["Household income"]
["MR results","method","nsnp","b","se","pval","lo_ci","up_ci","or","or_lci95","or_uci95"]
[null,"Inverse variance weighted (multiplicative random effects)",25,0.34753525414218,0.278100657199791,0.211418535992872,-0.197542033969411,0.89261254225377,1.41557421458964,0.82074564070549,2.44149984797803]
[null,"MR Egger",25,2.7199054441097,1.25316959596099,0.0405481596745991,0.263693036026156,5.17611785219325,15.1788869239291,1.30172855119677,176.994357262584]
[null,"Weighted median",25,0.353148600539916,0.355883677885358,0.321044040847417,-0.344383408115385,1.05068060919522,1.42354266692586,0.708657171045515,2.85959672371428]
[null,"MR PRESSO",25,0.3475353,0.2781007,0.2234684]
["Heterogeneity test","method","Q","Q_df","Q_pval"]
[null,"MR Egger",24.9916338156134,23,0.350716847961072]
[null,"Inverse variance weighted",29.0657971200142,24,0.217664416303603]
["Pleiotropy test","method"]
[null,"MR Egger","egger_intercept","se","pval"]
[null,null,-0.0470352606162681,0.0242905721650931,0.065205920697047]
[null,"MR PRESSO","Global Test`$Pvalue"]
[null,null,0.213]
["LDSC regression","Intercept (SE)","Heritability (se)","Rg (se)","P "]
[null,"-0.0014(0.0039)","0.377(0.021)","1.075(0.336)",0.615]
["Inflammatory bowel disease*"]
["MR results","method","nsnp","b","se","pval","lo_ci","up_ci","or","or_lci95","or_uci95","Power"]
[null,"Inverse variance weighted (multiplicative random effects)",87,0.191938439264268,0.0369260321933932,{"v":2.01534400743131e-07,"d":"2.02E-07"},0.119563416165217,0.264313462363319,1.21159592793231,1.12700471211809,1.30253642846202,{"v":1,"d":"100%"}]
[null,"MR Egger",87,0.075266807509336,0.102615576152296,0.465281970430879,-0.125859721749163,0.276393336767835,1.07817177683896,0.881738526846643,1.31836632400464]
[null,"Weighted median",87,0.137024757201543,0.0463947426960758,0.00314239025046138,0.046091061517234,0.227958452885851,1.14685654112747,1.04716976348286,1.25603313979604]
[null,"MR PRESSO",87,0.1919384,0.03692603,{"v":1.341796e-06,"d":"1.34E-06"}]
["Heterogeneity test","method","Q","Q_df","Q_pval"]
[null,"MR Egger",157.381918502006,85,3.05427350778996e-06]
[null,"Inverse variance weighted",160.129213236322,86,2.17190289937851e-06]
["Pleiotropy test","method"]
[null,"MR Egger","egger_intercept","se","pval"]
[null,null,0.0123882979070111,0.0101701408649372,0.226554538856131]
[null,"MR PRESSO","Global Test`$Pvalue"]
[null,null,0.097]
["LDSC regression","Intercept (SE)","Heritability (se)","Rg (se)","P "]
[null,"-0.0023(0.0027)","0.049(0.080)","1.078(0.457)",0.222]
["Systemic lupus erythematosus*（Suggestive)"]
["MR results","method","nsnp","b","se","pval","lo_ci","up_ci","or","or_lci95","or_uci95","Power"]
[null,"Inverse variance weighted (multiplicative random effects)",26,0.0823813130593717,0.0336280967256321,{"v":0.0142945006855313,"d":"1.43E-02"},0.0164702434771328,0.14829238264161,1.08586978722769,1.01660662565767,1.15985196737342,{"v":0.57,"d":"57%"}]
[null,"MR Egger",26,0.0400252072821355,0.0556091345329315,{"v":0.471673035940261,"d":"4.72E-01"},-0.0689686964024102,0.149019110966681,1.0408370105339,0.93335589701831,1.16069517100387]
[null,"Weighted median",26,0.0175298262819446,0.0324353386279067,0.588883598147873,-0.0460434374287525,0.0811030899926418,1.01768437543921,0.955000478524505,1.08448269011681]
[null,"MR PRESSO",26,0.08238131,0.0336281,{"v":0.02164173,"d":"2.16E-02"}]
["Heterogeneity test","method","Q","Q_df","Q_pval"]
[null,"MR Egger",61.428379952811,24,4.00408355565528e-05]
[null,"Inverse variance weighted",83.4459697760012,25,3.2588418657534e-08]
["Pleiotropy test","method"]
[null,"MR Egger","egger_intercept","se","pval"]
[null,null,0.0166582306063721,0.0177470834736163,0.358104315493447]
[null,"MR PRESSO","Global Test`$Pvalue"]
[null,null,"<0.001"]
["LDSC regression","Intercept (SE)","Heritability (se)","Rg (se)","P "]
[null,"-0.0008(0.0012)","0.797(0.201)","0.061(0.115)",0.713]
[" Rheumatoid arthritis*"]
["MR results","method","nsnp","b","se","pval","lo_ci","up_ci","or","or_lci95","or_uci95","Power"]
[null,"Inverse variance weighted (multiplicative random effects)",20,0.348551790290668,0.0878008771794778,{"v":7.19334395162671e-05,"d":"7.19E-05"},0.176462071018891,0.520641509562444,1.41701392858633,1.19298917703751,1.68310703270071,{"v":0.34,"d":"34%"}]
[null,"MR Egger",20,0.275382684143447,0.189861823598021,0.164139667780975,-0.096746490108674,0.647511858395568,1.31703458669464,0.907786109723295,1.91078061667923]
[null,"Weighted median",20,0.249054217306141,0.0933641350528836,{"v":0.00764047685335671,"d":"7.64E-03"},0.0660605126024891,0.432047922009793,1.28281158177267,1.06829136030054,1.54040893288433]
[null,"MR PRESSO",20,0.2490542,0.09336414,{"v":0.0152161,"d":"1.52E-02"}]
["Heterogeneity test","method","Q","Q_df","Q_pval"]
[null,"MR Egger",54.392919802334,18,1.59355401143984e-05]
[null,"Inverse variance weighted",54.4709068025194,19,2.80009317936442e-05]
["Pleiotropy test","method"]
[null,"MR Egger","egger_intercept","se","pval"]
[null,null,-0.00469720432509869,0.0292390513541955,0.87415960763718]
[null,"MR PRESSO","Global Test`$Pvalue"]
[null,null,0.117]
["LDSC regression","Intercept (SE)","Heritability (se)","Rg (se)","P "]
[null,"0.0014(0.0033)","0.125(0.039)","-0.214(0.187)",0.525]
["Cholelithiasis"]
["MR results","method","nsnp","b","se","pval","lo_ci","up_ci","or","or_lci95","or_uci95"]
[null,"Inverse variance weighted (multiplicative random effects)",24,-0.0930720036360049,0.0666763792246402,0.175531968176755,-0.2237577069163,0.0376136996442899,0.911127893413011,0.799508826362287,1.03833004812764]
[null,"MR Egger",24,-0.0619126539993251,0.122076280418926,0.617086193532505,-0.30118216362042,0.17735685562177,0.939964985387793,0.739942969778703,1.19405712310412]
[null,"Weighted median",24,-0.00866185634980244,0.0687334980208441,{"v":0.89971539137948,"d":"9.00E-01"},-0.143379512470657,0.126055799771052,0.991375549448779,0.866425187328626,1.13434546273421]
[null,"MR PRESSO",24,0.04002521,0.05560913,{"v":0.4789238,"d":"4.79E-01"}]
["Heterogeneity test","method","Q","Q_df","Q_pval"]
[null,"MR Egger",34.0068694601171,22,0.0490453296889824]
[null,"Inverse variance weighted",35.3687773292632,23,0.0477893166058645]
["Pleiotropy test","method"]
[null,"MR Egger","egger_intercept","se","pval"]
[null,null,0.0664975851577126,0.0226725253411353,0.0072732243992211]
[null,"MR PRESSO","Global Test`$Pvalue"]
[null,null,0.041]
["LDSC regression","Intercept (SE)","Heritability (se)","Rg (se)","P "]
[null,"0.0021(0.0037)","0.055(0.007)","-0.251(0.179)",0.338]
["Serum 25-Hydroxyvitamin D*（Suggestive)"]
["MR results","method","nsnp","b","se","pval","lo_ci","up_ci","or","or_lci95","or_uci95","Power"]
[null,"Inverse variance weighted (multiplicative random effects)",91,-0.299882530631309,0.142825440541968,{"v":0.0357601991405568,"d":"3.58E-02"},-0.579820394093566,-0.0199446671690518,0.740905249241911,0.55999893665026,0.980252911974817,{"v":0.65,"d":"65%"}]
[null,"MR Egger",91,-0.231157414470611,0.174820512608554,0.189471137559741,-0.573805619183377,0.111490790242154,0.793614529791038,0.563377354229579,1.11794344796968]
[null,"Weighted median",91,-0.200146659558977,0.115609324448922,{"v":0.0834102436319873,"d":"8.34E-02"},-0.426740935478863,0.0264476163609089,0.818610687191434,0.652632604282367,1.02680045830824]
[null,"MR PRESSO",91,-0.2001467,0.1156093,{"v":0.04683698,"d":"4.68E-02"}]
["Heterogeneity test","method","Q","Q_df","Q_pval"]
[null,"MR Egger",131.901782725784,89,0.00214053065783707]
[null,"Inverse variance weighted",131.98534910871,90,0.00262416289040775]
["Pleiotropy test","method"]
[null,"MR Egger","egger_intercept","se","pval"]
[null,null,0.00131999176253388,0.00555886014766961,0.812847833747096]
[null,"MR PRESSO","Global Test`$Pvalue"]
[null,null,0.005]
["LDSC regression","Intercept (SE)","Heritability (se)","Rg (se)","P "]
[null,"-0.0010(0.0013)","0.475(0.264)","0.077(0.719)",0.915]
["Serum calcium levels*（Suggestive)"]
["MR results","method","nsnp","b","se","pval","lo_ci","up_ci","or","or_lci95","or_uci95","Power"]
[null,"Inverse variance weighted (multiplicative random effects)",158,-0.181457253643207,0.0900400061817903,{"v":0.0438736561910283,"d":"4.39E-02"},-0.357935665759516,-0.00497884152689773,0.834053897306957,0.699118050788575,0.995033532360185,{"v":0.72,"d":"72%"}]
[null,"MR Egger",158,-0.285270521712161,0.156645116905114,0.0705036458421172,-0.592294950846184,0.0217539074218618,0.751810845650206,0.553056589512588,1.02199224881383]
[null,"Weighted median",158,-0.307187537954642,0.138952805448899,{"v":0.0270543391302568,"d":"2.71E-02"},-0.579535036634484,-0.0348400392748004,0.735512651434013,0.560158759326123,0.965759887554549]
[null,"MR PRESSO",158,-0.1814573,0.09004001,{"v":0.0455799,"d":"4.56E-02"}]
["Heterogeneity test","method","Q","Q_df","Q_pval"]
[null,"MR Egger",210.919435522277,156,0.0022449995100927]
[null,"Inverse variance weighted",211.80723964374,157,0.00233553780411781]
["Pleiotropy test","method"]
[null,"MR Egger","egger_intercept","se","pval"]
[null,null,0.00319434058909703,0.00394201835837663,0.418984255787064]
[null,"MR PRESSO","Global Test`$Pvalue"]
[null,null,0.002]
["LDSC regression","Intercept (SE)","Heritability (se)","Rg (se)","P "]
[null,"0.0004(0.0023)","0.960(0.061)","-0.005(0.249)",0.985]
["Testosterone"]
["MR results","method","nsnp","b","se","pval","lo_ci","up_ci","or","or_lci95","or_uci95"]
[null,"Inverse variance weighted (multiplicative random effects)",112,0.0157952702733085,0.181862962822407,{"v":0.93078868069327,"d":"9.31E-01"},-0.340656136858608,0.372246677405225,1.01592067495174,0.711303457199583,1.45099086381187]
[null,"MR Egger",112,0.436379853555034,0.366248740796069,0.236027705270169,-0.28146767840526,1.15422738551533,1.54709635319897,0.754675307590539,3.17157206815649]
[null,"Weighted median",112,-0.0261464698157061,0.282108718366998,{"v":0.926156001421964,"d":"9.26E-01"},-0.579079557815022,0.52678661818361,0.974192389378632,0.560413957890891,1.69348175247987]
[null,"MR PRESSO",112,0.01579527,0.181863,{"v":0.9309452,"d":"9.31E-01"}]
["Heterogeneity test","method","Q","Q_df","Q_pval"]
[null,"MR Egger",154.517780974914,110,0.00331320422470967]
[null,"Inverse variance weighted",156.971063701742,111,0.00269199305711922]
["Pleiotropy test","method"]
[null,"MR Egger","egger_intercept","se","pval"]
[null,null,-0.00694487939280886,0.00525513402074137,0.189062811109393]
[null,"MR PRESSO","Global Test`$Pvalue"]
[null,null,0.003]
["LDSC regression","Intercept (SE)","Heritability (se)","Rg (se)","P "]
[null,"0.0024(0.0030)","0.148(0.307)","-0.058(0.144)",0.797]
["C-reactive protein*（Suggestive)"]
["MR results","method","nsnp","b","se","pval","lo_ci","up_ci","or","or_lci95","or_uci95","Power"]
[null,"Inverse variance weighted (multiplicative random effects)",201,0.181458728871811,0.0828234944977674,{"v":0.0284583876208282,"d":"2.85E-02"},0.0191246796561871,0.343792778087435,1.1989650530482,1.01930872775688,1.41028636298869,{"v":0.73,"d":"73%"}]
[null,"MR Egger",201,0.139142103479533,0.155164714841505,0.370942244795719,-0.164980737609817,0.443264944568883,1.14928740613954,0.847910036704579,1.55778500634868]
[null,"Weighted median",201,0.063652496080842,0.124485038183517,{"v":0.609122467717877,"d":"6.09E-01"},-0.180338178758852,0.307643170920536,1.06572199183741,0.834987788525273,1.36021553787252]
[null,"MR PRESSO",201,0.1814587,0.08282349,{"v":0.02961393,"d":"2.96E-02"}]
["Heterogeneity test","method","Q","Q_df","Q_pval"]
[null,"MR Egger",272.936609725343,199,0.000391135203183631]
[null,"Inverse variance weighted",273.079521738819,200,0.000454461455138572]
["Pleiotropy test","method"]
[null,"MR Egger","egger_intercept","se","pval"]
[null,null,0.00131297968805677,0.00406750407480672,0.74718759846452]
[null,"MR PRESSO","Global Test`$Pvalue"]
[null,null,"<0.001"]
["LDSC regression","Intercept (SE)","Heritability (se)","Rg (se)","P "]
[null,"-0.0014(0.0027)","0.012(0.157)","0.011(0.182)",0.946]
[" Triglyceride"]
["MR results","method","nsnp","b","se","pval","lo_ci","up_ci","or","or_lci95","or_uci95"]
[null,"Inverse variance weighted (multiplicative random effects)",46,-0.0278761926943787,0.0729569560261055,{"v":0.702393903758884,"d":"7.02E-01"},-0.170871826505546,0.115119441116788,0.972508763037771,0.842929607781313,1.12200744339096]
[null,"MR Egger",46,0.0132875160738155,0.126652144341228,0.916921277221949,-0.234950686834992,0.261525718982623,1.01337618742091,0.79060983614076,1.29891034779499]
[null,"Weighted median",46,-0.00422126424266848,0.0876101491977257,{"v":0.961570904041796,"d":"9.62E-01"},-0.175937156670211,0.167494628184874,0.995787632769952,0.838670686539573,1.18233893886167]
[null,"MR PRESSO",46,-0.01578806,0.1176354,{"v":0.8938762,"d":"8.94E-01"}]
["Heterogeneity test","method","Q","Q_df","Q_pval"]
[null,"MR Egger",66.0220115303619,44,0.017435174841241]
[null,"Inverse variance weighted",66.2614938181846,45,0.0211890074037781]
["Pleiotropy test","method"]
[null,"MR Egger","egger_intercept","se","pval"]
[null,null,-0.0029013080196311,0.00726231658415928,0.691456226868045]
[null,"MR PRESSO","Global Test`$Pvalue"]
[null,null,0.017]
["LDSC regression","Intercept (SE)","Heritability (se)","Rg (se)","P "]
[null,"0.0007(0.0019)","0.067(0.072)","-0.160(0.314)",0.601]
[" HDL-C"]
["MR results","method","nsnp","b","se","pval","lo_ci","up_ci","or","or_lci95","or_uci95"]
[null,"Inverse variance weighted (multiplicative random effects)",65,0.0126518241593496,0.0635355694925885,{"v":0.842161224344858,"d":"8.42E-01"},-0.111877892046124,0.137181540364823,1.01273219708366,0.894153434080844,1.14703636301997]
[null,"MR Egger",65,-0.0802166446999865,0.096892779444424,0.410857546659338,-0.270126492411058,0.109693203011085,0.922916379784355,0.763282938730967,1.11593565223719]
[null,"Weighted median",65,0.00029326351988836,0.0784675151148138,{"v":0.997018003059074,"d":"9.97E-01"},-0.153503066105147,0.154089593144923,1.00029330652584,0.857698134402132,1.16659540104732]
[null,"MR PRESSO",65,0.01265182,0.0635355694925885,{"v":0.8427925,"d":"8.43E-01"}]
["Heterogeneity test","method","Q","Q_df","Q_pval"]
[null,"MR Egger",78.7215038479948,63,0.0874140950097009]
[null,"Inverse variance weighted",80.7212937949344,64,0.0772704216810863]
["Pleiotropy test","method"]
[null,"MR Egger","egger_intercept","se","pval"]
[null,null,0.0077075636587151,0.00609258148319735,0.210504337826991]
[null,"MR PRESSO","Global Test`$Pvalue"]
[null,null,0.097]
["LDSC regression","Intercept (SE)","Heritability (se)","Rg (se)","P "]
[null,"-0.0019(0.0033)","0.703(0.159)","0.129(0.042)",0.186]
[" LDL-C"]
["MR results","method","nsnp","b","se","pval","lo_ci","up_ci","or","or_lci95","or_uci95"]
[null,"Inverse variance weighted (multiplicative random effects)",34,-0.0655066239883518,0.0741969594311327,{"v":0.377303933064069,"d":"3.77E-01"},-0.210932664473372,0.0799194164966683,0.936592842758999,0.809828595280348,1.08319977612511]
[null,"MR Egger",34,0.0117612818668763,0.0987499542912924,0.905939394613896,-0.181788628544057,0.205311192277809,1.01183071769355,0.833777558567823,1.22790712072753]
[null,"Weighted median",34,0.0328801424877586,0.0927213018938934,{"v":0.722879831006124,"d":"7.23E-01"},-0.148853609224272,0.21461389419979,1.0334266678685,0.861695249902307,1.23938327150216]
[null,"MR PRESSO",34,-0.06550662,0.07419696,{"v":0.3836904,"d":"3.84E-01"}]
["Heterogeneity test","method","Q","Q_df","Q_pval"]
[null,"MR Egger",41.2763996865164,32,0.126119129180233]
[null,"Inverse variance weighted",43.0632309607358,33,0.1128331019871]
["Pleiotropy test","method"]
[null,"MR Egger","egger_intercept","se","pval"]
[null,null,-0.00846599948297137,0.00719303842760643,0.247887640609733]
[null,"MR PRESSO","Global Test`$Pvalue"]
[null,null,0.148]
["LDSC regression","Intercept (SE)","Heritability (se)","Rg (se)","P "]
[null,"-0.0009(0.0016)","0.703(0.159)","0.123(0.225)",0.938]
[" Apolipoprotein A-I"]
["MR results","method","nsnp","b","se","pval","lo_ci","up_ci","or","or_lci95","or_uci95"]
[null,"Inverse variance weighted (multiplicative random effects)",50,0.00960594816303301,0.0472516969703568,{"v":0.838905878766512,"d":"8.39E-01"},-0.0830073778988664,0.102219274224932,1.0096522333688,0.920344356987488,1.1076263190045]
[null,"MR Egger",50,-0.0632077098705982,0.0833949062582144,0.452196624226686,-0.226661726136698,0.100246306395502,0.938748466114914,0.797190405362558,1.10544316226726]
[null,"Weighted median",50,0.00430375883835631,0.0612605741440927,{"v":0.943992034345739,"d":"9.44E-01"},-0.115766966484065,0.124374484160778,1.00431303330868,0.890682758049948,1.13243987239856]
[null,"MR PRESSO",50,0.009605948,0.0472517,{"v":0.8397478,"d":"8.40E-01"}]
["Heterogeneity test","method","Q","Q_df","Q_pval"]
[null,"MR Egger",47.9348685533346,48,0.475494253039987]
[null,"Inverse variance weighted",49.0570475411171,49,0.470838473471935]
["Pleiotropy test","method"]
[null,"MR Egger","egger_intercept","se","pval"]
[null,null,0.00659570529668498,0.00622630192205428,0.294751489601101]
[null,"MR PRESSO","Global Test`$Pvalue"]
[null,null,0.557]
["LDSC regression","Intercept (SE)","Heritability (se)","Rg (se)","P "]
[null,"-0.0015(0.0026)","0.007(0.003)","0.003(0.245)",0.389]
[" Total cholesterol"]
["MR results","method","nsnp","b","se","pval","lo_ci","up_ci","or","or_lci95","or_uci95"]
[null,"Inverse variance weighted (multiplicative random effects)",46,-0.0278761926943787,0.0729569560261055,{"v":0.702393903758884,"d":"7.02E-01"},-0.170871826505546,0.115119441116788,0.972508763037771,0.842929607781313,1.12200744339096]
[null,"MR Egger",46,0.0132875160738155,0.126652144341228,0.916921277221949,-0.234950686834992,0.261525718982623,1.01337618742091,0.79060983614076,1.29891034779499]
[null,"Weighted median",46,-0.00422126424266848,0.0876101491977257,{"v":0.961570904041796,"d":"9.62E-01"},-0.175937156670211,0.167494628184874,0.995787632769952,0.838670686539573,1.18233893886167]
[null,"MR PRESSO",46,-0.02787619,0.07295696,{"v":0.7041925,"d":"7.04E-01"}]
["Heterogeneity test","method","Q","Q_df","Q_pval"]
[null,"MR Egger",66.0220115303619,44,0.017435174841241]
[null,"Inverse variance weighted",66.2614938181846,45,0.0211890074037781]
["Pleiotropy test","method"]
[null,"MR Egger","egger_intercept","se","pval"]
[null,null,-0.0029013080196311,0.00726231658415928,0.691456226868045]
[null,"MR PRESSO","Global Test`$Pvalue"]
[null,null,0.017]
["LDSC regression","Intercept (SE)","Heritability (se)","Rg (se)","P "]
[null,"0.0024(0.0016)","0.261(0.169)","-0.092(0.110)",0.354]
["Fasting glucose"]
["MR results","method","nsnp","b","se","pval","lo_ci","up_ci","or","or_lci95","or_uci95"]
[null,"Inverse variance weighted (multiplicative random effects)",52,0.226137511203774,0.216014894688783,{"v":0.295163814139145,"d":"2.95E-01"},-0.197251682386242,0.649526704793789,1.25374805782962,0.820983980101084,1.91463442723695]
[null,"MR Egger",52,0.795845287324546,0.46899322556676,0.0959288585673121,-0.123381434786302,1.7150720094354,2.21631362705343,0.883926437958343,5.55707565983476]
[null,"Weighted median",52,0.194381404932187,0.254525120679025,{"v":0.445044705292924,"d":"4.45E-01"},-0.304487831598701,0.693250641463076,1.21455943358506,0.737501002388159,2.00020693251079]
[null,"MR PRESSO",52,0.2261375,0.216014894688783,{"v":0.3001001,"d":"3.00E-01"}]
["Heterogeneity test","method","Q","Q_df","Q_pval"]
[null,"MR Egger",84.5545234410146,50,0.00163023032890162]
[null,"Inverse variance weighted",87.7076909064732,51,0.00106254602673887]
["Pleiotropy test","method"]
[null,"MR Egger","egger_intercept","se","pval"]
[null,null,-0.0135291759668272,0.00990789163465026,0.178209505502848]
[null,"MR PRESSO","Global Test`$Pvalue"]
[null,null,0.003]
["LDSC regression","Intercept (SE)","Heritability (se)","Rg (se)","P "]
[null,"-0.0035(0.0012)","0.074(0.168)","0.143(0.162)",0.629]
["Fasting insulin"]
["MR results","method","nsnp","b","se","pval","lo_ci","up_ci","or","or_lci95","or_uci95"]
[null,"Inverse variance weighted (multiplicative random effects)",32,-0.0682826464458748,0.145288721806349,{"v":0.638370029659028,"d":"6.38E-01"},-0.353048541186319,0.216483248294569,0.933996445489894,0.702543090274503,1.2417022845487]
[null,"MR Egger",32,-0.263265459210251,0.516672114349488,0.614101310162178,-1.27594280333525,0.749411884914746,0.768537854777897,0.279167643923615,2.11575534300896]
[null,"Weighted median",32,-0.00177135709535451,0.11175246861344,{"v":0.987353484756358,"d":"9.87E-01"},-0.220806195577696,0.217263481386987,0.998230210831702,0.801872071585544,1.24267147981198]
[null,"MR PRESSO",32,-0.06828265,0.1452887,{"v":0.6416595,"d":"6.42E-01"}]
["Heterogeneity test","method","Q","Q_df","Q_pval"]
[null,"MR Egger",62.4291837353576,30,0.000463154923535035]
[null,"Inverse variance weighted",62.7517734102194,31,0.000631780112606764]
["Pleiotropy test","method"]
[null,"MR Egger","egger_intercept","se","pval"]
[null,null,0.00564909453641661,0.0143478494864495,0.696569266008279]
[null,"MR PRESSO","Global Test`$Pvalue"]
[null,null,0.177]
["LDSC regression","Intercept (SE)","Heritability (se)","Rg (se)","P "]
[null,"0.0048(0.0021)","0.097(0.061)","-0.233(0.432)",0.577]
["HbA1c"]
["MR results","method","nsnp","b","se","pval","lo_ci","up_ci","or","or_lci95","or_uci95"]
[null,"Inverse variance weighted (multiplicative random effects)",61,0.120055688711153,0.309548429329926,{"v":0.698133424015294,"d":"6.98E-01"},-0.486659232775501,0.726770610197807,1.12755964217422,0.614676458850709,2.0683901723473]
[null,"MR Egger",61,0.585016692432121,0.689553194473621,0.39964443384421,-0.766507568736177,1.93654095360042,1.79502094865516,0.464632936619447,6.93472191092193]
[null,"Weighted median",61,-0.243426407563273,0.388445513866941,{"v":0.53087682619287,"d":"5.31E-01"},-1.00477961474248,0.517926799615932,0.783937165755752,0.366125314535106,1.67854408164458]
[null,"MR PRESSO",61,0.1200557,0.309548429329926,{"v":0.699506,"d":"7.00E-01"}]
["Heterogeneity test","method","Q","Q_df","Q_pval"]
[null,"MR Egger",103.039079700803,59,0.000341509687786873]
[null,"Inverse variance weighted",104.035345850782,60,0.000367341164721366]
["Pleiotropy test","method"]
[null,"MR Egger","egger_intercept","se","pval"]
[null,null,-0.00764909822402541,0.0101273898961473,0.453080770544438]
[null,"MR PRESSO","Global Test`$Pvalue"]
[null,null,0.001]
["LDSC regression","Intercept (SE)","Heritability (se)","Rg (se)","P "]
[null,"-0.0010(0.0015)","0.723(0.061)","0.044(0.167)",0.815]
["Type 2 diabetes "]
["MR results","method","nsnp","b","se","pval","lo_ci","up_ci","or","or_lci95","or_uci95"]
[null,"Inverse variance weighted (multiplicative random effects)",25,-0.0978806109580503,0.0601384888034674,{"v":0.10361252846237,"d":"1.04E-01"},-0.215752049012846,0.0199908270967459,0.906757154159752,0.80593510950719,1.02019198186148]
[null,"MR Egger",25,-0.0570984794362337,0.120503107367944,0.640085287179524,-0.293284569877404,0.179087611004937,0.944501050855383,0.745809875471679,1.19612553333748]
[null,"Weighted median",25,-0.0877025856819159,0.0677853997819612,{"v":0.195725157553467,"d":"1.96E-01"},-0.22056196925456,0.045156797890728,0.916033277625961,0.80206793376959,1.04619188773007]
[null,"MR PRESSO",25,-0.0978806109580503,0.0601384888034674,{"v":0.1166714,"d":"1.17E-01"}]
["Heterogeneity test","method","Q","Q_df","Q_pval"]
[null,"MR Egger",38.6706172007158,23,0.0215557981121441]
[null,"Inverse variance weighted",38.9302057082434,24,0.0277732629340172]
["Pleiotropy test","method"]
[null,"MR Egger","egger_intercept","se","pval"]
[null,null,-0.0052193205932265,0.0132830521277013,0.697988828555976]
[null,"MR PRESSO","Global Test`$Pvalue"]
[null,null,0.051]
["LDSC regression","Intercept (SE)","Heritability (se)","Rg (se)","P "]
[null,"-0.0037(0.0021)","0.167(0.113)","0.532(0.281)",0.115]
["Body mass index "]
["MR results","method","nsnp","b","se","pval","lo_ci","up_ci","or","or_lci95","or_uci95"]
[null,"Inverse variance weighted (multiplicative random effects)",523,0.169905592933683,0.0611996875691187,{"v":0.00549900167531039,"d":"5.50E-03"},0.0499542052982104,0.289856980569156,1.18519295544862,1.05122295483199,1.33623636659413]
[null,"MR Egger",523,0.503776394627559,0.172934999578951,0.00373224460543277,0.164823795452815,0.842728993802303,1.65495926399792,1.1791853225888,2.32269696122024]
[null,"Weighted median",523,-0.0257153169365456,0.113467886008092,{"v":0.82071084621286,"d":"8.21E-01"},-0.248112373512405,0.196681739639314,0.974612505792861,0.7802722564172,1.21735654271419]
[null,"MR PRESSO",523,0.1699056,0.0611996875691187,{"v":0.005696477,"d":"5.70E-03"}]
["Heterogeneity test","method","Q","Q_df","Q_pval"]
[null,"MR Egger",607.337195555111,521,0.00523220889634725]
[null,"Inverse variance weighted",612.299774697764,522,0.00381020273352629]
["Pleiotropy test","method"]
[null,"MR Egger","egger_intercept","se","pval"]
[null,null,-0.00480652695914044,0.00232955912685299,0.0395810967958438]
[null,"MR PRESSO","Global Test`$Pvalue"]
[null,null,0.002]
["LDSC regression","Intercept (SE)","Heritability (se)","Rg (se)","P "]
[null,"0.0021(0.0018)","0.480(0.054)","-0.278(0.019)",0.426]
[" Whole body fat mass"]
["MR results","method","nsnp","b","se","pval","lo_ci","up_ci","or","or_lci95","or_uci95"]
[null,"Inverse variance weighted (multiplicative random effects)",346,0.121238558049682,0.0615611664167328,{"v":0.0489071815209649,"d":"4.89E-02"},0.000578671872885309,0.241898444226478,1.1288941870428,1.00057883933575,1.2736648382301]
[null,"MR Egger",346,0.20505469057785,0.22332237445539,0.359157296668758,-0.232657163354715,0.642766544510415,1.22759220085414,0.792425199356996,1.901734842381]
[null,"Weighted median",346,-0.0120922469947503,0.0999053082504547,{"v":0.903661663845641,"d":"9.04E-01"},-0.207906651165642,0.183722157176141,0.987980570419694,0.812282858830972,1.20168189801718]
[null,"MR PRESSO",346,0.1212386,0.0615611664167328,{"v":0.04970697,"d":"4.97E-02"}]
["Heterogeneity test","method","Q","Q_df","Q_pval"]
[null,"MR Egger",413.42311983802,344,0.00600058490445923]
[null,"Inverse variance weighted",413.606367218734,345,0.00654469072100828]
["Pleiotropy test","method"]
[null,"MR Egger","egger_intercept","se","pval"]
[null,null,-0.00131417731553792,0.00336552822632361,0.696422049354288]
[null,"MR PRESSO","Global Test`$Pvalue"]
[null,null,0.011]
["LDSC regression","Intercept (SE)","Heritability (se)","Rg (se)","P "]
[null,"-0.0041(0.0009)","0.730(0.073)","0.086(0.222)",0.698]
["Waist circumference*（Suggestive)"]
["MR results","method","nsnp","b","se","pval","lo_ci","up_ci","or","or_lci95","or_uci95","Power"]
[null,"Inverse variance weighted (multiplicative random effects)",263,0.240645318379234,0.106457861359242,{"v":0.0237917955083546,"d":"2.38E-02"},0.0319879101151191,0.449302726643348,1.27206977551647,1.0325050223628,1.56721902434867,{"v":0.92,"d":"92%"}]
[null,"MR Egger",263,0.268409288230647,0.30064006136424,0.372790546771346,-0.320845232043264,0.857663808504558,1.307882331329,0.725535531952989,2.35764634159007]
[null,"Weighted median",263,0.29951774434087,0.164682328537624,{"v":0.0689479491467747,"d":"6.89E-02"},-0.0232596195928731,0.622295108274613,1.34920798747048,0.977008800217145,1.86319938269701]
[null,"MR PRESSO",263,0.2406453,0.106457861359242,{"v":0.0246128,"d":"2.46E-02"}]
["Heterogeneity test","method","Q","Q_df","Q_pval"]
[null,"MR Egger",301.220393849088,261,0.0439902791375243]
[null,"Inverse variance weighted",301.231653760503,262,0.0480707700830612]
["Pleiotropy test","method"]
[null,"MR Egger","egger_intercept","se","pval"]
[null,null,-0.000456359819986439,0.00462021138122633,0.921393004541299]
[null,"MR PRESSO","Global Test`$Pvalue"]
[null,null,0.053]
["LDSC regression","Intercept (SE)","Heritability (se)","Rg (se)","P "]
[null,"0.0013(0.0072)","0.241(0.064)","-0.428(0.008)",0.749]
["Hip circumference"]
["MR results","method","nsnp","b","se","pval","lo_ci","up_ci","or","or_lci95","or_uci95"]
[null,"Inverse variance weighted (multiplicative random effects)",335,0.167846008524204,0.0666503004722219,{"v":0.011792003583919,"d":"1.18E-02"},0.0372114195986492,0.298480597449759,1.18275446251835,1.03791243267331,1.34780938600376]
[null,"MR Egger",335,0.215285765839387,0.226076491855739,0.341650961100957,-0.227824158197862,0.658395689876636,1.24021625777147,0.796264264068967,1.93169081603723]
[null,"Weighted median",335,-0.00269330576846629,0.12471027681974,{"v":0.9827698237174,"d":"9.83E-01"},-0.247125448335156,0.241738836798223,0.997310317925546,0.78104270687811,1.27346156808296]
[null,"MR PRESSO",335,0.167846,0.0666503004722219,{"v":0.01225889,"d":"1.23E-02"}]
["Heterogeneity test","method","Q","Q_df","Q_pval"]
[null,"MR Egger",368.767974610789,333,0.0861477700909183]
[null,"Inverse variance weighted",368.821392889604,334,0.0919740540347529]
["Pleiotropy test","method"]
[null,"MR Egger","egger_intercept","se","pval"]
[null,null,-0.0008646305181885,0.00393677049756039,0.826294365302027]
[null,"MR PRESSO","Global Test`$Pvalue"]
[null,null,0.077]
["LDSC regression","Intercept (SE)","Heritability (se)","Rg (se)","P "]
[null,"-0.0012(0.0023)","0.035(0.226)","0.038(0.051)",0.497]
["Waist-to-hip ratio"]
["MR results","method","nsnp","b","se","pval","lo_ci","up_ci","or","or_lci95","or_uci95"]
[null,"Inverse variance weighted (multiplicative random effects)",30,-0.0224383734707733,0.158937203522484,{"v":0.887729638817674,"d":"8.88E-01"},-0.333955292374841,0.289078545433295,0.977811494465236,0.716085796006922,1.33519659800527]
[null,"MR Egger",30,0.197724666610451,0.782827521263203,0.80243969615336,-1.33661727506543,1.73206660828633,1.21862681897362,0.262732920270595,5.65232298408692]
[null,"Weighted median",30,-0.0251766316015433,0.218675885536145,{"v":0.908340352866892,"d":"9.08E-01"},-0.453781367252387,0.4034281040493,0.975137656689886,0.635221598308531,1.49694760383885]
[null,"MR PRESSO",30,-0.02243837,0.158937203522484,{"v":0.8887058,"d":"8.89E-01"}]
["Heterogeneity test","method","Q","Q_df","Q_pval"]
[null,"MR Egger",40.402674977133,28,0.0608572925767903]
[null,"Inverse variance weighted",40.5218816692783,29,0.0757589782214489]
["Pleiotropy test","method"]
[null,"MR Egger","egger_intercept","se","pval"]
[null,null,-0.00660529370267562,0.0229809437073278,0.775903613113021]
[null,"MR PRESSO","Global Test`$Pvalue"]
[null,null,0.111]
["LDSC regression","Intercept (SE)","Heritability (se)","Rg (se)","P "]
[null,"-0.0022（0.0007）","0.137(0.194)","0.007(0.161)",0.856]

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["Past tobacco smoking"]
["MR results","method","nsnp","b","se","pval","lo_ci","up_ci","or","or_lci95","or_uci95"]
[null,"Inverse variance weighted (multiplicative random effects)",90,0.509383940221071,0.191378940730743,0.00777584656276011,0.134281216388815,0.884486664053328,1.66426559196928,1.14371440565989,2.42174090568946]
[null,"MR Egger",90,-0.0708442229126509,0.838432935880179,0.932854019528763,-1.7141727772378,1.5724843314125,0.931607003850372,0.1801126523906,4.81860434624504]
[null,"Weighted median",90,0.625784143179046,0.303613269651226,0.0392913542030632,0.0307021346626429,1.22086615169545,1.86971150428071,1.03117830586302,3.39012282295242]
[null,"MR PRESSO",90,0.5093839,0.1905111,0.008922971]
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[null,"MR Egger",87.689378409265,88,0.489288785365888]
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["Pleiotropy test","method"]
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[null,null,0.0113432147240242,0.0159582975360043,0.479085674476171]
[null,"MR PRESSO","Global Test`$Pvalue"]
[null,null,0.489]
["LDSC regression","Intercept (SE)","Heritability (se)","Rg (se)","P "]
[null,"0.0015(0.0030)","0.469(0.069)","-1.095(0.193)",0.136]
["Smoking initiation*（Suggestive)"]
["MR results","method","nsnp","b","se","pval","lo_ci","up_ci","or","or_lci95","or_uci95","Power"]
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[null,"MR Egger",83,-0.824083977088186,0.863088782406802,0.342515748228188,-2.51573799060552,0.867570036429147,0.438636609676006,0.0808032581519337,2.38111778842246]
[null,"Weighted median",83,-0.439226533459784,0.219146671305345,0.0450423990085622,-0.86875400921826,-0.00969905770130769,0.64453475440276,0.419473884360788,0.990347826459013]
[null,"MR PRESSO",83,-0.4615329,0.1583699,0.004594213]
["Heterogeneity test","method","Q","Q_df","Q_pval"]
[null,"MR Egger",93.1775288427356,81,0.167421680300681]
[null,"Inverse variance weighted",93.3876550918324,82,0.183364350073103]
["Pleiotropy test","method"]
[null,"MR Egger","egger_intercept","se","pval"]
[null,null,0.00946687048099987,0.0221502874286627,0.670227387501088]
[null,"MR PRESSO","Global Test`$Pvalue"]
[null,null,0.196]
["LDSC regression","Intercept (SE)","Heritability (se)","Rg (se)","P "]
[null,"-0.0021(0.0013)","0.284(0.051)","0.090(0.134)",0.503]
["Cigarettes per day"]
["MR results","method","nsnp","b","se","pval","lo_ci","up_ci","or","or_lci95","or_uci95"]
[null,"Inverse variance weighted (multiplicative random effects)",16,0.0149043900124541,0.134933347963113,0.912046614008695,-0.249564971995247,0.279373752020155,1.01501601430782,0.779139656926629,1.32230146436808]
[null,"MR Egger",16,-0.0414644142969068,0.2203531686258,0.853441657732616,-0.473356624803474,0.390427796209661,0.959383475069522,0.622907887159006,1.47761277583811]
[null,"Weighted median",16,-0.0424007836595955,0.162095661392255,0.793646213677729,-0.360108279988415,0.275306712669224,0.958485558232912,0.697600785776351,1.31693453343613]
[null,"MR PRESSO",16,0.01490439,0.1169995,0.900325]
["Heterogeneity test","method","Q","Q_df","Q_pval"]
[null,"MR Egger",11.1730019061574,14,0.672394961666717]
[null,"Inverse variance weighted",11.2777003590199,15,0.732671722270386]
["Pleiotropy test","method"]
[null,"MR Egger","egger_intercept","se","pval"]
[null,null,0.00489770144386022,0.0151363853477463,0.751045416195426]
[null,"MR PRESSO","Global Test`$Pvalue"]
[null,null,0.761]
["LDSC regression","Intercept (SE)","Heritability (se)","Rg (se)","P "]
[null,"0.0024(0.0021)","0.147(0.107)","-0.533(0.068)",0.307]
["Alcoholic drinks per week"]
["MR results","method","nsnp","b","se","pval","lo_ci","up_ci","or","or_lci95","or_uci95"]
[null,"Inverse variance weighted (multiplicative random effects)",31,0.377671132694344,0.485827095784999,0.436935986578105,-0.574549975044255,1.32989224043294,1.4588830850259,0.562958157029374,3.7806359659225]
[null,"MR Egger",31,-0.170411625537809,1.78230037484752,0.924485357540228,-3.66372036023894,3.32289710916333,0.843317614076136,0.0256369563714133,27.7406018057618]
[null,"Weighted median",31,0.534094900908089,0.664381093529294,0.421455651732468,-0.768092042409326,1.8362818442255,1.70590353156424,0.463897320899467,6.27317022086013]
[null,"MR PRESSO",31,0.3776711,0.3776711,0.4430233]
["Heterogeneity test","method","Q","Q_df","Q_pval"]
[null,"MR Egger",39.6076183762591,29,0.0905598222572405]
[null,"Inverse variance weighted",39.7474864064765,30,0.109848380294176]
["Pleiotropy test","method"]
[null,"MR Egger","egger_intercept","se","pval"]
[null,null,0.00849292969743164,0.0265392512051253,0.751252078646374]
[null,"MR PRESSO","Global Test`$Pvalue"]
[null,null,0.116]
["LDSC regression","Intercept (SE)","Heritability (se)","Rg (se)","P "]
[null,"-0.0031(0.0016)","0.377(0.167）","0.211(0.087)",0.796]
["Coffee intake"]
["MR results","method","nsnp","b","se","pval","lo_ci","up_ci","or","or_lci95","or_uci95"]
[null,"Inverse variance weighted (multiplicative random effects)",36,0.495478830466804,0.485280668881595,0.307247343459309,-0.455671280541123,1.44662894147473,1.64128394769025,0.634022218287708,4.24876750253454]
[null,"MR Egger",36,-0.819075573280797,1.18493657292148,0.494107731525365,-3.14155125620689,1.5034001096453,0.440838989542095,0.0432157072439225,4.49695323979282]
[null,"Weighted median",36,0.605888508774716,0.690666089641279,0.380349541380834,-0.74781702692219,1.95959404447162,1.83288001559527,0.473398842528977,7.09644563899178]
[null,"MR PRESSO",36,0.4954788,0.4852807,0.3142532]
["Heterogeneity test","method","Q","Q_df","Q_pval"]
[null,"MR Egger",42.6389402313442,34,0.146980256575756]
[null,"Inverse variance weighted",44.488453094064,35,0.130632355042655]
["Pleiotropy test","method"]
[null,"MR Egger","egger_intercept","se","pval"]
[null,null,0.0208238459191225,0.0171473102661647,0.23295917317776]
[null,"MR PRESSO","Global Test`$Pvalue"]
[null,null,0.096]
["LDSC regression","Intercept (SE)","Heritability (se)","Rg (se)","P "]
[null,"-0.0014(0.0020)","0.776(0.394)","0.831(0.080)",0.442]
["Education level"]
["MR results","method","nsnp","b","se","pval","lo_ci","up_ci","or","or_lci95","or_uci95"]
[null,"Inverse variance weighted (multiplicative random effects)",381,0.0244665550729124,0.146975384436366,0.867789430896778,-0.263605198422364,0.312538308568189,1.02476831723241,0.768276796680982,1.36689030378123]
[null,"MR Egger",381,0.0788749216030318,0.605737946735585,0.896467036355568,-1.10837145399872,1.26612129720478,1.08206897015349,0.330096100262658,3.5470678243014]
[null,"Weighted median",381,0.146874815009191,0.213726494114435,0.491950901871712,-0.272029113455101,0.565778743473484,1.15820896357571,0.761832081202882,1.76081847483905]
[null,"MR PRESSO",381,0.02446656,0.1469754,0.867878]
["Heterogeneity test","method","Q","Q_df","Q_pval"]
[null,"MR Egger",422.980015373697,379,0.0589674768962494]
[null,"Inverse variance weighted",422.989584350658,380,0.0632369104638454]
["Pleiotropy test","method"]
[null,"MR Egger","egger_intercept","se","pval"]
[null,null,-0.00074227420085918,0.00801626251547528,0.926273411688835]
[null,"MR PRESSO","Global Test`$Pvalue"]
[null,null,0.073]
["LDSC regression","Intercept (SE)","Heritability (se)","Rg (se)","P "]
[null,"-0.0022(0.0008)","0.359(0.012)","0.617(0.466)",0.185]
["Household income"]
["MR results","method","nsnp","b","se","pval","lo_ci","up_ci","or","or_lci95","or_uci95"]
[null,"Inverse variance weighted (multiplicative random effects)",40,0.539231698579944,0.347949546054812,0.121203678565769,-0.142749411687488,1.22121280884738,1.71468895801447,0.866971294550945,3.39129823699598]
[null,"MR Egger",40,-0.455664743373217,1.84327264711078,0.806080957057558,-4.06847913171035,3.15714964496392,0.634026363010953,0.0171033807264966,23.5035070212834]
[null,"Weighted median",40,0.467191719793537,0.443528531412287,0.292179638701577,-0.402124201774545,1.33650764136162,1.59550726441958,0.668897662254258,3.80572929831532]
[null,"MR PRESSO",40,0.5392317,0.3479495,0.1292814]
["Heterogeneity test","method","Q","Q_df","Q_pval"]
[null,"MR Egger",52.3288203721087,38,0.0608582144196463]
[null,"Inverse variance weighted",52.7450989399377,39,0.0697876867843137]
["Pleiotropy test","method"]
[null,"MR Egger","egger_intercept","se","pval"]
[null,null,0.0190404598042165,0.034630924062036,0.585666313096835]
[null,"MR PRESSO","Global Test`$Pvalue"]
[null,null,0.071]
["LDSC regression","Intercept (SE)","Heritability (se)","Rg (se)","P "]
[null,"-0.0033(0.0012)","0.045(0.080)","0.950(0.621)",0.127]
["Inflammatory bowel disease*"]
["MR results","method","nsnp","b","se","pval","lo_ci","up_ci","or","or_lci95","or_uci95","Power"]
[null,"Inverse variance weighted (multiplicative random effects)",146,0.22468691292782,0.0371001804982515,{"v":1.39356032429803e-09,"d":"1.39E-09"},0.151970559151247,0.297403266704393,1.25193069151136,1.16412596307119,1.3463581313943,{"v":1,"d":"100%"}]
[null,"MR Egger",146,0.150122708707413,0.0893153523841062,0.0949664241467401,-0.0249353819654355,0.325180799380261,1.16197681865391,0.975372936674182,1.38428090048605]
[null,"Weighted median",146,0.214479657751112,0.0565609582978756,0.000149433552119342,0.103620179487276,0.325339136014949,1.23921691225923,1.10917908592924,1.38450010021852]
[null,"MR PRESSO",146,0.2246869,0.03710018,{"v":1.139611e-08,"d":"1.14E-08"}]
["Heterogeneity test","method","Q","Q_df","Q_pval"]
[null,"MR Egger",228.40648003508,144,9.44481883714741e-06]
[null,"Inverse variance weighted",229.742792584136,145,9.28842409150773e-06]
["Pleiotropy test","method"]
[null,"MR Egger","egger_intercept","se","pval"]
[null,null,0.00824359612329322,0.00898122646367587,0.360221848768126]
[null,"MR PRESSO","Global Test`$Pvalue"]
[null,null,"<0.001"]
["LDSC regression","Intercept (SE)","Heritability (se)","Rg (se)","P "]
[null,"-0.0019(0.0036)","0.049(0.080)","0.586(0.545)",0.282]
["Systemic lupus erythematosus"]
["MR results","method","nsnp","b","se","pval","lo_ci","up_ci","or","or_lci95","or_uci95"]
[null,"Inverse variance weighted (multiplicative random effects)",34,0.0420066910997872,0.0300083821160124,{"v":0.161563657311166,"d":"1.62E-01"},-0.0168097378475972,0.100823120047172,1.04290145688513,0.983330757464345,1.10608098090796]
[null,"MR Egger",34,-0.017502669404019,0.0694003021935758,0.802500304488109,-0.153527261703428,0.11852192289539,0.982649612572747,0.857677382133683,1.12583155531886]
[null,"Weighted median",34,0.0535075641370718,0.0331567140172135,0.106575663368716,-0.0114795953366667,0.11849472361081,1.05496497163706,0.988586043807515,1.12580093392244]
[null,"MR PRESSO",34,0.04200669,0.03000838,{"v":0.170895,"d":"1.71E-01"}]
["Heterogeneity test","method","Q","Q_df","Q_pval"]
[null,"MR Egger",63.1286426786207,32,0.000839197353580481]
[null,"Inverse variance weighted",64.9139135913683,33,0.000753361402730612]
["Pleiotropy test","method"]
[null,"MR Egger","egger_intercept","se","pval"]
[null,null,0.0231875910795465,0.0243748417609124,0.348586538688914]
[null,"MR PRESSO","Global Test`$Pvalue"]
[null,null,"<0.001"]
["LDSC regression","Intercept (SE)","Heritability (se)","Rg (se)","P "]
[null,"0.0010(0.0025)","0.246(0.132)","-0.084(0.129)",0.32]
[" Rheumatoid arthritis*"]
["MR results","method","nsnp","b","se","pval","lo_ci","up_ci","or","or_lci95","or_uci95","Power"]
[null,"Inverse variance weighted (multiplicative random effects)",23,0.433854257533378,0.0956428715893608,{"v":5.72795248739083e-06,"d":"5.73E-06"},0.246394229218231,0.621314285848525,1.5431939428346,1.27940385251503,1.86137281087592,{"v":0.38,"d":"38%"}]
[null,"MR Egger",23,0.533080516140106,0.22774789129959,0.0291978006179386,0.0866946491929098,0.979466383087301,1.70417396637677,1.09056362438862,2.66303482229609]
[null,"Weighted median",23,0.533477530197088,0.121341544899283,{"v":1.10012748675442e-05,"d":"1.10E-05"},0.295648102194493,0.771306958199682,1.70485068172082,1.34399712396879,2.16259082339484]
[null,"MR PRESSO",23,0.4338543,0.09564287,{"v":0.0001628284,"d":"1.63E-04"}]
["Heterogeneity test","method","Q","Q_df","Q_pval"]
[null,"MR Egger",28.5259985543874,21,0.12585420470794]
[null,"Inverse variance weighted",28.8415014978809,22,0.1494419170164]
["Pleiotropy test","method"]
[null,"MR Egger","egger_intercept","se","pval"]
[null,null,-0.0145175736897881,0.0301233391922856,0.634834840570814]
[null,"MR PRESSO","Global Test`$Pvalue"]
[null,null,0.161]
["LDSC regression","Intercept (SE)","Heritability (se)","Rg (se)","P "]
[null,"-0.0012(0.0029)","0.300(0.001)","1.066(0.800)",0.183]
["Cholelithiasis"]
["MR results","method","nsnp","b","se","pval","lo_ci","up_ci","or","or_lci95","or_uci95"]
[null,"Inverse variance weighted (multiplicative random effects)",39,0.0385278236950582,0.0439549480184587,{"v":0.380742059927829,"d":"3.81E-01"},-0.0476238744211209,0.124679521811237,1.03927964455561,0.953492352503506,1.1327853618875]
[null,"MR Egger",39,0.123174175873619,0.0693599637783731,0.0839798439748059,-0.0127713531319921,0.25911970487923,1.13108141088442,0.987309854520265,1.29578890779929]
[null,"Weighted median",39,0.0994396721152534,0.0568875933793982,{"v":0.0804635437828958,"d":"8.05E-02"},-0.0120600109083672,0.210939355138874,1.10455183345422,0.98801241956005,1.23483746624395]
[null,"MR PRESSO",39,0.03852782,0.04395495,{"v":0.3862497,"d":"3.86E-01"}]
["Heterogeneity test","method","Q","Q_df","Q_pval"]
[null,"MR Egger",43.163372932321,37,0.22460249336817]
[null,"Inverse variance weighted",45.9979028573192,38,0.174823249434467]
["Pleiotropy test","method"]
[null,"MR Egger","egger_intercept","se","pval"]
[null,null,-0.0187173941818263,0.012007751417323,0.12756292714937]
[null,"MR PRESSO","Global Test`$Pvalue"]
[null,null,0.162]
["LDSC regression","Intercept (SE)","Heritability (se)","Rg (se)","P "]
[null,"-0.0026(0.0044)","0.389(0.392)","0.160(0.300)",0.607]
["Serum 25-Hydroxyvitamin D"]
["MR results","method","nsnp","b","se","pval","lo_ci","up_ci","or","or_lci95","or_uci95"]
[null,"Inverse variance weighted (multiplicative random effects)",142,0.121528389648078,0.145686329308578,{"v":0.404180458877239,"d":"4.04E-01"},-0.164016815796735,0.40707359509289,1.12922142366892,0.848727749726885,1.50241467194067]
[null,"MR Egger",142,-0.251753956280153,0.230365653295177,0.276338793037024,-0.703270636738699,0.199762724178394,0.777435997783693,0.494963806762247,1.22111298319687]
[null,"Weighted median",142,-0.0121046653741326,0.217670683460671,{"v":0.955652502865397,"d":"9.56E-01"},-0.438739204957047,0.414529874208782,0.987968301378329,0.644848931106999,1.51365896327495]
[null,"MR PRESSO",142,0.1215284,0.1456863,{"v":0.4055915,"d":"4.06E-01"}]
["Heterogeneity test","method","Q","Q_df","Q_pval"]
[null,"MR Egger",191.859094225248,140,0.00239164994189337]
[null,"Inverse variance weighted",197.765389501741,141,0.0011486007446336]
["Pleiotropy test","method"]
[null,"MR Egger","egger_intercept","se","pval"]
[null,null,0.0129780731182898,0.00625143638554484,0.0397216530761686]
[null,"MR PRESSO","Global Test`$Pvalue"]
[null,null,0.002]
["LDSC regression","Intercept (SE)","Heritability (se)","Rg (se)","P "]
[null,"0.0018(0.0006)","0.475(0.264)","-0.067(0.392)",0.865]
["Serum calcium levels"]
["MR results","method","nsnp","b","se","pval","lo_ci","up_ci","or","or_lci95","or_uci95"]
[null,"Inverse variance weighted (multiplicative random effects)",257,-0.0532016521439269,0.100503621331854,{"v":0.596562261048706,"d":"5.97E-01"},-0.250188749954361,0.143785445666508,0.948188788900494,0.778653798331261,1.15463634971456]
[null,"MR Egger",257,0.102537801341781,0.177616910886856,0.564247828086289,-0.245591343996457,0.450666946680019,1.10797918421802,0.782241827436292,1.56935851497972]
[null,"Weighted median",257,0.129535148831468,0.160994432964764,{"v":0.421054027033468,"d":"4.21E-01"},-0.18601393977947,0.445084237442406,1.13829912064359,0.830262021231787,1.5606216530724]
[null,"MR PRESSO",257,-0.05320165,0.1005036,{"v":0.597021,"d":"5.97E-01"}]
["Heterogeneity test","method","Q","Q_df","Q_pval"]
[null,"MR Egger",292.136332758088,255,0.0548055706653372]
[null,"Inverse variance weighted",293.431649787681,256,0.0538075207037096]
["Pleiotropy test","method"]
[null,"MR Egger","egger_intercept","se","pval"]
[null,null,-0.00480839521827702,0.00452204432881579,0.288641256444326]
[null,"MR PRESSO","Global Test`$Pvalue"]
[null,null,0.05]
["LDSC regression","Intercept (SE)","Heritability (se)","Rg (se)","P "]
[null,"-0.0036(0.0022)","0.961(0.061)","0.658(0.619)",0.288]
["Testosterone"]
["MR results","method","nsnp","b","se","pval","lo_ci","up_ci","or","or_lci95","or_uci95"]
[null,"Inverse variance weighted (multiplicative random effects)",183,0.252677641652558,0.25642733210868,{"v":0.324438834048626,"d":"3.24E-01"},-0.249919929280455,0.75527521258557,1.28746818381776,0.778863144707125,2.12819714940586]
[null,"MR Egger",183,0.382179421254149,0.577569620902595,0.509003240707046,-0.749857035714936,1.51421587822323,1.46547499890832,0.472434089115045,4.5458552249018]
[null,"Weighted median",183,0.527957805402903,0.365802684318371,{"v":0.14893998937506,"d":"1.49E-01"},-0.189015455861105,1.24493106666691,1.69546629857515,0.827773712640333,3.47269540661667]
[null,"MR PRESSO",183,0.2526776,0.2564273,{"v":0.325747,"d":"3.26E-01"}]
["Heterogeneity test","method","Q","Q_df","Q_pval"]
[null,"MR Egger",233.248206501441,181,0.00533536273044964]
[null,"Inverse variance weighted",233.329000955977,182,0.00609622020903519]
["Pleiotropy test","method"]
[null,"MR Egger","egger_intercept","se","pval"]
[null,null,-0.00185473022966531,0.00740729844313831,0.802567999910034]
[null,"MR PRESSO","Global Test`$Pvalue"]
[null,null,0.007]
["LDSC regression","Intercept (SE)","Heritability (se)","Rg (se)","P "]
[null,"0.0028(0.0009)","0.528(0.362)","-0.092(0.108)",0.395]
["C-reactive protein"]
["MR results","method","nsnp","b","se","pval","lo_ci","up_ci","or","or_lci95","or_uci95"]
[null,"Inverse variance weighted (multiplicative random effects)",193,-0.161306075877173,0.105657941735868,{"v":0.126840110013826,"d":"1.27E-01"},-0.368395641679475,0.0457834899251293,0.851031551011249,0.691843405446791,1.04684773333771]
[null,"MR Egger",193,-0.307957683713296,0.188305131369271,0.103608256365653,-0.677035741197067,0.0611203737704749,0.734946417554373,0.508120964224574,1.06302686703806]
[null,"Weighted median",193,-0.176716680121399,0.158785940455503,{"v":0.265741081967777,"d":"2.66E-01"},-0.487937123414185,0.134503763171388,0.838017177817371,0.613891471229115,1.14396896394557]
[null,"MR PRESSO",193,-0.1613061,0.1056579,{"v":0.1284857,"d":"1.28E-01"}]
["Heterogeneity test","method","Q","Q_df","Q_pval"]
[null,"MR Egger",227.532723826393,191,0.0362981752503039]
[null,"Inverse variance weighted",228.587553689685,192,0.0364323121007505]
["Pleiotropy test","method"]
[null,"MR Egger","egger_intercept","se","pval"]
[null,null,0.00506078434361927,0.00537813713594958,0.347897511180782]
[null,"MR PRESSO","Global Test`$Pvalue"]
[null,null,0.041]
["LDSC regression","Intercept (SE)","Heritability (se)","Rg (se)","P "]
[null,"0.0027(0.0033)","0.253(0.259)","-0.219(0.202)",0.057]
[" Triglyceride"]
["MR results","method","nsnp","b","se","pval","lo_ci","up_ci","or","or_lci95","or_uci95"]
[null,"Inverse variance weighted (multiplicative random effects)",68,-0.140813110622047,0.0841747291941119,{"v":0.0943535191212027,"d":"9.44E-02"},-0.305795579842507,0.0241693585984121,0.868651638292975,0.736537167111789,1.02446380495357]
[null,"MR Egger",68,-0.183714279799264,0.136462526467234,0.182823843305387,-0.451180831675043,0.0837522720765149,0.832173538652744,0.636875664471207,1.0873594911321]
[null,"Weighted median",68,-0.131825774417803,0.131768253063705,{"v":0.317099296961115,"d":"3.17E-01"},-0.390091550422664,0.126440001587059,0.876493689400687,0.676994892492419,1.13478136405265]
[null,"MR PRESSO",68,-0.1408131,0.0766171,{"v":0.07051381,"d":"7.05E-02"}]
["Heterogeneity test","method","Q","Q_df","Q_pval"]
[null,"MR Egger",55.3493773465495,66,0.822072114681235]
[null,"Inverse variance weighted",55.5089134801008,67,0.840711701762764]
["Pleiotropy test","method"]
[null,"MR Egger","egger_intercept","se","pval"]
[null,null,0.00324051171282663,0.00811304835252531,0.690873547395357]
[null,"MR PRESSO","Global Test`$Pvalue"]
[null,null,0.814]
["LDSC regression","Intercept (SE)","Heritability (se)","Rg (se)","P "]
[null,"-0.0031(0.0014)","0.060(0.123)","0.041(0.122)",0.741]
[" HDL-C"]
["MR results","method","nsnp","b","se","pval","lo_ci","up_ci","or","or_lci95","or_uci95"]
[null,"Inverse variance weighted (multiplicative random effects)",85,0.0468102680813111,0.10056993487533,{"v":0.641609292844999,"d":"6.42E-01"},-0.150306804274335,0.243927340436957,1.04792316574391,0.860443948043525,1.2762515952372]
[null,"MR Egger",85,0.0909739560676519,0.193494721300505,0.639472010928068,-0.288275697681338,0.470223609816642,1.09524048051804,0.74955491319828,1.60035200762945]
[null,"Weighted median",85,0.130025911790717,0.158484997197679,{"v":0.411970783457958,"d":"4.12E-01"},-0.180604682716734,0.440656506298168,1.13885789278967,0.834765290624451,1.55372691526155]
[null,"MR PRESSO",85,0.04681027,0.1005699,{"v":0.6428138,"d":"6.43E-01"}]
["Heterogeneity test","method","Q","Q_df","Q_pval"]
[null,"MR Egger",92.5237829223905,83,0.222443723081917]
[null,"Inverse variance weighted",92.6036801375833,84,0.244020138615642]
["Pleiotropy test","method"]
[null,"MR Egger","egger_intercept","se","pval"]
[null,null,-0.00237535613467624,0.00887259290053713,0.789580275569283]
[null,"MR PRESSO","Global Test`$Pvalue"]
[null,null,0.244]
["LDSC regression","Intercept (SE)","Heritability (se)","Rg (se)","P "]
[null,"0.0042(0.0018)","0.043(0.192)","-0.390(0.930)",0.701]
[" LDL-C"]
["MR results","method","nsnp","b","se","pval","lo_ci","up_ci","or","or_lci95","or_uci95"]
[null,"Inverse variance weighted (multiplicative random effects)",50,0.00605498251242186,0.106174080952477,{"v":0.954522237745413,"d":"9.55E-01"},-0.202046216154433,0.214156181179277,1.00607335097389,0.817057165829477,1.23881611944773]
[null,"MR Egger",50,0.404254958360663,0.149325047793475,0.00937060528738815,0.111577864685451,0.696932052035874,1.49818587328264,1.11804079651127,2.00758408629414]
[null,"Weighted median",50,0.19946005770151,0.146764138567172,{"v":0.174130194311616,"d":"1.74E-01"},-0.0881976538901477,0.487117769293168,1.22074344915797,0.91557989091046,1.62761828154638]
[null,"MR PRESSO",50,0.006054983,0.1061741,{"v":0.9547542,"d":"9.55E-01"}]
["Heterogeneity test","method","Q","Q_df","Q_pval"]
[null,"MR Egger",50.8165020546826,48,0.363243071816733]
[null,"Inverse variance weighted",63.6242179615947,49,0.0781785089938168]
["Pleiotropy test","method"]
[null,"MR Egger","egger_intercept","se","pval"]
[null,null,-0.0325273785362737,0.00935179516561856,0.0010833437918333]
[null,"MR PRESSO","Global Test`$Pvalue"]
[null,null,0.075]
["LDSC regression","Intercept (SE)","Heritability (se)","Rg (se)","P "]
[null,"-0.0033(0.0014)","0.282(0.241)","0.051(0.170)",0.771]
[" Apolipoprotein A-I"]
["MR results","method","nsnp","b","se","pval","lo_ci","up_ci","or","or_lci95","or_uci95"]
[null,"Inverse variance weighted (multiplicative random effects)",71,0.0206778400880266,0.0996946931089567,{"v":0.835688390569168,"d":"8.36E-01"},-0.174723758405529,0.216079438581582,1.02089310782037,0.839688945747303,1.24120097432934]
[null,"MR Egger",71,-0.36483525662921,0.201586646703153,0.0746789182956279,-0.759945084167391,0.0302745709089703,0.694311024595132,0.467692110006327,1.03073750563768]
[null,"Weighted median",71,-0.185154749705276,0.152419622825023,{"v":0.22445391477054,"d":"2.24E-01"},-0.483897210442321,0.113587711031769,0.830975680660056,0.616376555729706,1.1202901463878]
[null,"MR PRESSO",71,0.02067784,0.09510279,{"v":0.8285087,"d":"8.29E-01"}]
["Heterogeneity test","method","Q","Q_df","Q_pval"]
[null,"MR Egger",58.8588020469664,69,0.80291971725728]
[null,"Inverse variance weighted",63.7001483613443,70,0.688812405533261]
["Pleiotropy test","method"]
[null,"MR Egger","egger_intercept","se","pval"]
[null,null,0.0210688859386829,0.00957543465715065,0.0311358076885753]
[null,"MR PRESSO","Global Test`$Pvalue"]
[null,null,0.666]
["LDSC regression","Intercept (SE)","Heritability (se)","Rg (se)","P "]
[null,"0.0024(0.0034)","0.033(0.0094)","-0.127(0.218)",0.562]
[" Total cholesterol"]
["MR results","method","nsnp","b","se","pval","lo_ci","up_ci","or","or_lci95","or_uci95"]
[null,"Inverse variance weighted (multiplicative random effects)",62,0.0205037780850365,0.0876557954860497,{"v":0.81505298121185,"d":"8.15E-01"},-0.151301581067621,0.192309137237694,1.02071542458558,0.859588423970386,1.21204514734463]
[null,"MR Egger",62,0.215408639435263,0.141482811409541,0.133135361791776,-0.0618976709274363,0.492714949797963,1.24036865696545,0.93997906905625,1.63675389785749]
[null,"Weighted median",62,0.130651830769197,0.136270399873883,{"v":0.337675145073652,"d":"3.38E-01"},-0.136438152983614,0.397741814522007,1.13957094869289,0.872460277656141,1.48845968161847]
[null,"MR PRESSO",62,0.02050378,0.0843935,{"v":0.8088558,"d":"8.09E-01"}]
["Heterogeneity test","method","Q","Q_df","Q_pval"]
[null,"MR Egger",53.4640356922686,60,0.711689932659071]
[null,"Inverse variance weighted",56.5440077088205,61,0.637922910208136]
["Pleiotropy test","method"]
[null,"MR Egger","egger_intercept","se","pval"]
[null,null,-0.0145586659690575,0.00829560751668776,0.084366722164686]
[null,"MR PRESSO","Global Test`$Pvalue"]
[null,null,0.616]
["LDSC regression","Intercept (SE)","Heritability (se)","Rg (se)","P "]
[null,"-0.0039(0.0027)","0.087(0.030)","0.011(0.183)",0.953]
["Fasting glucose"]
["MR results","method","nsnp","b","se","pval","lo_ci","up_ci","or","or_lci95","or_uci95"]
[null,"Inverse variance weighted (multiplicative random effects)",70,-0.283971799522001,0.237110474868184,{"v":0.231059150857988,"d":"2.31E-01"},-0.748708330263641,0.180764731219638,0.752787873384727,0.472977088542082,1.19813326277998]
[null,"MR Egger",70,-0.673911136561079,0.479740638114003,0.164650102350632,-1.61420278726452,0.266380514142368,0.509711124362154,0.199049291835359,1.30523162329774]
[null,"Weighted median",70,-0.552855879266015,0.348869659578098,{"v":0.113033124227291,"d":"1.13E-01"},-1.23664041203909,0.130928653507057,0.57530446195601,0.290358064619539,1.13988645151006]
[null,"MR PRESSO",70,-0.2839718,0.2371105,{"v":0.2351572,"d":"2.35E-01"}]
["Heterogeneity test","method","Q","Q_df","Q_pval"]
[null,"MR Egger",86.7106889591383,68,0.0626198574761219]
[null,"Inverse variance weighted",87.8261116225892,69,0.0627635865540059]
["Pleiotropy test","method"]
[null,"MR Egger","egger_intercept","se","pval"]
[null,null,0.0101109647937578,0.0108107227118444,0.352957791732713]
[null,"MR PRESSO","Global Test`$Pvalue"]
[null,null,0.059]
["LDSC regression","Intercept (SE)","Heritability (se)","Rg (se)","P "]
[null,"-0.004(0.0035)","0.158(0.034)","0.095(0.140)",0.479]
["Fasting insulin"]
["MR results","method","nsnp","b","se","pval","lo_ci","up_ci","or","or_lci95","or_uci95"]
[null,"Inverse variance weighted (multiplicative random effects)",38,-0.491114612764818,0.418018186739978,{"v":0.240049040506732,"d":"2.40E-01"},-1.31043025877517,0.328201033245538,0.611943933395802,0.269703988909025,1.3884680724772]
[null,"MR Egger",38,-0.276325596083579,1.37716505644172,0.842103012518639,-2.97556910670936,2.4229179145422,0.758565904460397,0.051018390832083,11.278721692805]
[null,"Weighted median",38,-0.400159952335214,0.573796926215213,{"v":0.485559069891645,"d":"4.86E-01"},-1.52480192771703,0.724482023046605,0.670212835353464,0.217664165833993,2.06366189377773]
[null,"MR PRESSO",38,-0.4911146,0.4180182,{"v":0.2475548,"d":"2.48E-01"}]
["Heterogeneity test","method","Q","Q_df","Q_pval"]
[null,"MR Egger",44.2708661483375,36,0.162067323454158]
[null,"Inverse variance weighted",44.3039059844643,37,0.190716743167578]
["Pleiotropy test","method"]
[null,"MR Egger","egger_intercept","se","pval"]
[null,null,-0.00355486771343926,0.0216876382615554,0.870717099476014]
[null,"MR PRESSO","Global Test`$Pvalue"]
[null,null,0.212]
["LDSC regression","Intercept (SE)","Heritability (se)","Rg (se)","P "]
[null,"0.0026(0.0034)","0.725(0.290)","-0.143(0.683)",0.834]
["HbA1c*"]
["MR results","method","nsnp","b","se","pval","lo_ci","up_ci","or","or_lci95","or_uci95","Power"]
[null,"Inverse variance weighted (multiplicative random effects)",70,-1.31670187231741,0.328670647289494,{"v":6.17180862306298e-05,"d":"6.17E-05"},-1.96089634100482,-0.672507403630005,0.268017802800516,0.14073222031034,0.510427125072072,{"v":1,"d":"100%"}]
[null,"MR Egger",70,-1.4911047965427,0.588050557868642,0.0135265773749897,-2.64368388996524,-0.338525703120164,0.225123802100301,0.0710988661210091,0.71282045744355]
[null,"Weighted median",70,-1.71466035650961,0.543886139667817,{"v":0.00161818377193412,"d":"1.62E-03"},-2.78067719025853,-0.648643522760691,0.180024854600634,0.0619965097263134,0.522754400482387]
[null,"MR PRESSO",70,-1.316702,0.3286706,{"v":0.0001536334,"d":"1.54E-04"}]
["Heterogeneity test","method","Q","Q_df","Q_pval"]
[null,"MR Egger",79.903855727079,68,0.153146953123838]
[null,"Inverse variance weighted",80.0550458781628,69,0.170774535196459]
["Pleiotropy test","method"]
[null,"MR Egger","egger_intercept","se","pval"]
[null,null,0.00328670373251458,0.00916280025847352,0.72093023212427]
[null,"MR PRESSO","Global Test`$Pvalue"]
[null,null,0.19]
["LDSC regression","Intercept (SE)","Heritability (se)","Rg (se)","P "]
[null,"-0.0030(0.0034)","0.160(0.036)","0.037(0.184)",0.265]
["Type 2 diabetes*（Suggestive)"]
["MR results","method","nsnp","b","se","pval","lo_ci","up_ci","or","or_lci95","or_uci95","Power"]
[null,"Inverse variance weighted (multiplicative random effects)",44,-0.131024728486963,0.0597170582030392,{"v":0.028228785665975,"d":"2.82E-02"},-0.24807016256492,-0.0139792944090066,0.877196082390952,0.78030519314358,0.986117962206675,{"v":0.4,"d":"40%"}]
[null,"MR Egger",44,-0.301162439839017,0.128775191826909,0.0241864041252527,-0.553561815819759,-0.0487630638582745,0.73995756439602,0.574898476823516,0.952406762550833]
[null,"Weighted median",44,-0.186388260127738,0.0895328492960284,{"v":0.0373619925939781,"d":"3.74E-02"},-0.361872644747954,-0.0109038755075225,0.82995129542197,0.69637104870509,0.98915535626226]
[null,"MR PRESSO",44,-0.1310247,0.05971706,{"v":0.03368055,"d":"3.37E-02"}]
["Heterogeneity test","method","Q","Q_df","Q_pval"]
[null,"MR Egger",45.537824871649,42,0.327076995627107]
[null,"Inverse variance weighted",47.93102307799,43,0.279621121754669]
["Pleiotropy test","method"]
[null,"MR Egger","egger_intercept","se","pval"]
[null,null,0.0203520094419128,0.0136987032305986,0.144829629550301]
[null,"MR PRESSO","Global Test`$Pvalue"]
[null,null,0.242]
["LDSC regression","Intercept (SE)","Heritability (se)","Rg (se)","P "]
[null,"-0.0044(0.0036)","0.113(0.023)","0.051(0.170)",0.771]
["Body mass index*（Suggestive)"]
["MR results","method","nsnp","b","se","pval","lo_ci","up_ci","or","or_lci95","or_uci95","Power"]
[null,"Inverse variance weighted (multiplicative random effects)",360,-0.252650402715419,0.110377181087828,{"v":0.0220809130922995,"d":"2.21E-02"},-0.468989677647561,-0.0363111277832772,0.776739380341595,0.62563404113805,0.96434021377094,{"v":0.64,"d":"64%"}]
[null,"MR Egger",360,-0.0803809930758502,0.333899042987138,0.809898761532212,-0.734823117330641,0.57406113117894,0.922764712439761,0.479590282682151,1.77546281747407]
[null,"Weighted median",360,-0.112162657273625,0.171671197407628,{"v":0.513525857693569,"d":"5.14E-01"},-0.448638204192575,0.224312889645325,0.893898846525329,0.638497062470641,1.25146252784218]
[null,"MR PRESSO",360,-0.2526504,0.1103772,{"v":0.02266105,"d":"2.27E-02"}]
["Heterogeneity test","method","Q","Q_df","Q_pval"]
[null,"MR Egger",392.751177666224,358,0.0996335407260413]
[null,"Inverse variance weighted",393.079108300254,359,0.104130702688537]
["Pleiotropy test","method"]
[null,"MR Egger","egger_intercept","se","pval"]
[null,null,-0.003212458873078,0.00587575686545657,0.584904102532654]
[null,"MR PRESSO","Global Test`$Pvalue"]
[null,null,0.09]
["LDSC regression","Intercept (SE)","Heritability (se)","Rg (se)","P "]
[null,"0.0018(0.0025)","0.480(0.054)","-0.278(0.019)",0.426]
[" Whole body fat mass"]
["MR results","method","nsnp","b","se","pval","lo_ci","up_ci","or","or_lci95","or_uci95"]
[null,"Inverse variance weighted (multiplicative random effects)",205,-0.0448686885085026,0.125714359711309,{"v":0.721159323788113,"d":"7.21E-01"},-0.291268833542668,0.201531456525663,0.956123023530661,0.747314747739779,1.2232747164301]
[null,"MR Egger",205,0.0258845884803194,0.373314282020291,0.944789422604108,-0.705811404279451,0.75758058124009,1.02622250373994,0.49370781505533,2.13310908814407]
[null,"Weighted median",205,0.137707328592917,0.194163259563574,{"v":0.478178819571222,"d":"4.78E-01"},-0.242852660151688,0.518267317337521,1.1476396198156,0.784387076730737,1.67911575297743]
[null,"MR PRESSO",205,-0.04486869,0.1257144,{"v":0.7215282,"d":"7.22E-01"}]
["Heterogeneity test","method","Q","Q_df","Q_pval"]
[null,"MR Egger",220.916907734892,203,0.184814806304766]
[null,"Inverse variance weighted",220.961025411691,204,0.197584249379136]
["Pleiotropy test","method"]
[null,"MR Egger","egger_intercept","se","pval"]
[null,null,-0.00153510123814925,0.00762425061444377,0.840630782699801]
[null,"MR PRESSO","Global Test`$Pvalue"]
[null,null,0.185]
["LDSC regression","Intercept (SE)","Heritability (se)","Rg (se)","P "]
[null,"0.0027(0.0047)","0.026(0.191)","-0.062(0.133)",0.64]
["Waist circumference"]
["MR results","method","nsnp","b","se","pval","lo_ci","up_ci","or","or_lci95","or_uci95"]
[null,"Inverse variance weighted (multiplicative random effects)",237,-0.117033581568986,0.141273641860795,{"v":0.407434001546957,"d":"4.07E-01"},-0.393929919616143,0.159862756478172,0.889555319998475,0.674401316887564,1.17334982527846]
[null,"MR Egger",237,-0.256893044916321,0.403966352449476,0.525442934560152,-1.04866709571729,0.534881005884651,0.773450933851055,0.350404493629407,1.70724507804903]
[null,"Weighted median",237,-0.00260429587197611,0.222708843822489,{"v":0.990669970369174,"d":"9.91E-01"},-0.439113629764054,0.433905038020102,0.997399092364557,0.644607528866734,1.54327230896384]
[null,"MR PRESSO",237,-0.1170336,0.1412736,{"v":0.408271,"d":"4.08E-01"}]
["Heterogeneity test","method","Q","Q_df","Q_pval"]
[null,"MR Egger",254.944331252424,235,0.177300859305642]
[null,"Inverse variance weighted",255.092565223351,236,0.187631700242102]
["Pleiotropy test","method"]
[null,"MR Egger","egger_intercept","se","pval"]
[null,null,0.00254067888352537,0.00687328979769926,0.711979716972874]
[null,"MR PRESSO","Global Test`$Pvalue"]
[null,null,0.174]
["LDSC regression","Intercept (SE)","Heritability (se)","Rg (se)","P "]
[null,"0.0042(0.0017)","0.690(0.114)","-0.428(0.008)",0.346]
["Hip circumference"]
["MR results","method","nsnp","b","se","pval","lo_ci","up_ci","or","or_lci95","or_uci95"]
[null,"Inverse variance weighted (multiplicative random effects)",209,-0.0414456524951161,0.125103144554011,{"v":0.740424045037476,"d":"7.40E-01"},-0.286647815820978,0.203756510830746,0.959401475000977,0.750776093743971,1.22599959948637]
[null,"MR Egger",209,0.233980696874705,0.366001775728078,0.523342129254938,-0.483382783552327,0.951344177301737,1.26362010015524,0.616693717975735,2.58918764854219]
[null,"Weighted median",209,0.100505584764508,0.198742767742391,{"v":0.613062438563732,"d":"6.13E-01"},-0.289030240010577,0.490041409539594,1.10572981692747,0.748989555608122,1.63238381481805]
[null,"MR PRESSO",209,-0.04144565,0.1251031,{"v":0.7407576,"d":"7.41E-01"}]
["Heterogeneity test","method","Q","Q_df","Q_pval"]
[null,"MR Egger",234.700318484062,207,0.0905409037244837]
[null,"Inverse variance weighted",235.427503518053,208,0.0930586344468798]
["Pleiotropy test","method"]
[null,"MR Egger","egger_intercept","se","pval"]
[null,null,-0.00619664391882442,0.00773759049585407,0.424137126375841]
[null,"MR PRESSO","Global Test`$Pvalue"]
[null,null,0.089]
["LDSC regression","Intercept (SE)","Heritability (se)","Rg (se)","P "]
[null,"-0.0047(0.0020)","0.081(0.141)","0.220(0.223)",0.901]
["Waist-to-hip ratio"]
["MR results","method","nsnp","b","se","pval","lo_ci","up_ci","or","or_lci95","or_uci95"]
[null,"Inverse variance weighted (multiplicative random effects)",21,-0.0659731294008637,0.237726179648625,{"v":0.781382917730181,"d":"7.81E-01"},-0.531916441512168,0.399970182710441,0.936156019026772,0.587478022888916,1.49178021613545]
[null,"MR Egger",21,0.0445886522235226,1.34395283436865,0.97387930376368,-2.58955890313903,2.67873620758607,1.04559766715989,0.0750531384887829,14.5666724081579]
[null,"Weighted median",21,-0.0571313500282178,0.342975862494633,{"v":0.867704131587281,"d":"8.68E-01"},-0.729364040517699,0.615101340461264,0.944470005056961,0.48221556215543,1.84984405410951]
[null,"MR PRESSO",21,-0.06597313,0.2115821,{"v":0.7584132,"d":"7.58E-01"}]
["Heterogeneity test","method","Q","Q_df","Q_pval"]
[null,"MR Egger",15.8358812644226,19,0.668198585871515]
[null,"Inverse variance weighted",15.8428675701336,20,0.726323394406994]
["Pleiotropy test","method"]
[null,"MR Egger","egger_intercept","se","pval"]
[null,null,-0.00351820615098558,0.042091799270216,0.93426145286095]
[null,"MR PRESSO","Global Test`$Pvalue"]
[null,null,0.721]
["LDSC regression","Intercept (SE)","Heritability (se)","Rg (se)","P "]
[null,"0.0043(0.0021)","0.105(0.023)","-0.059(0.232)",0.795]

{"sheet":"Table1-GWAS datebase summary","index":3,"n_rows":38,"n_cols":6,"rows_kept":38,"merged":[[3,1,3,5],[11,1,11,5],[16,1,16,5],[21,1,21,5],[27,1,27,5],[32,1,32,5]],"flags":["formulas_cached_only"]}
[]
[]
[null,"Exposure","GWAS ID","Sample","Ancestry","Consortium or PubMed ID  "]
[null,"Lifestyle behaviors"]
[null,"  Past tobacco smoking","ukb-b-2134",424960,"European","UK Biobank"]
[null,"  Smoking initiation","ieu-b-4877",607291,"European","GSCAN"]
[null,"  Cigarettes per day","ieu-b-25",337334,"European","GSCAN"]
[null,"  Alcoholic drinks per week","ieu-b-73",335394,"European","GSCAN"]
[null,"  Coffee intake","ukb-b-5237",428860,"European","UK Biobank"]
[null,"  Education level","ieu-a-1239",766345,"European","SSGAC"]
[null,"  Household income","ukb-b-7408",397755,"European","UK Biobank"]
[null,"Related diseases"]
[null,"  Inflammatory bowel disease ","ieu-a-294",65642,"European","IIBDGC"]
[null,"  Systemic lupus erythematosus","ebi-a-GCST003156",14267,"European",26502338]
[null,"  Rheumatoid arthritis","ebi-a-GCST90018910",417256,"European",34594039]
[null,"  Cholelithiasis","finn-b-K11_CHOLELITH",214167,"European"," FinnGen"]
[null,"Serum parameters"]
[null,"  Serum 25-Hydroxyvitamin D","ebi-a-GCST90000618",496946,"European",32242144]
[null,"  Serum calcium levels","ebi-a-GCST90025990",400792,"European","UK Biobank"]
[null,"  Testosterone","ebi-a-GCST90012114",425097,"European","UK Biobank"]
[null,"  C-reactive protein","ebi-a-GCST90029070",575531,"European","CHARGE"]
[null,"Lipid metabolism"]
[null,"  Triglyceride","met-d-Total_TG",115078,"European","UK Biobank"]
[null,"  HDL-C","met-d-HDL_C",115078,"European","UK Biobank"]
[null,"  LDL-C","met-d-LDL_C",115078,"European","UK Biobank"]
[null,"  Apolipoprotein A-I","met-d-ApoA1",115078,"European","UK Biobank"]
[null,"  Total cholesterol","met-d-Total_C",115078,"European","UK Biobank"]
[null,"Glucose metabolism"]
[null,"  Fasting glucose","ebi-a-GCST90002232",200622,"European",34059833]
[null,"  Fasting insulin","ebi-a-GCST90002238",151013,"European",34059833]
[null,"  HbA1c","ebi-a-GCST90002244",146806,"European",34059833]
[null,"  Type 2 diabetes ","finn-b-E4_DM2_STRICT",212351,"European"," FinnGen"]
[null,"Obesity traits"]
[null,"  Body mass index","ieu-b-40",681275,"European","GIANT"]
[null,"  Whole body fat mass","ukb-b-19393",454137,"European","UK Biobank"]
[null,"  Waist circumference","ukb-b-9405",462166,"European","UK Biobank"]
[null,"  Hip circumference","ukb-b-15590",462117,"European","UK Biobank"]
[null,"  Waist-to-hip ratio","ieu-a-79",210082,"European","GIANT"]

{"sheet":"Multivariable MR analysis","index":4,"n_rows":60,"n_cols":10,"rows_kept":60,"flags":["formulas_cached_only"]}
["PBC"]
["Exposure","nsnp","b","se","pval","lo_ci","up_ci","or","or_lci95","or_uci95"]
["Lipid metabolism"]
["  Triglyceride",26,{"v":0.154930834334065,"d":"0.155"},0.208062877054466,0.456492595530049,-0.25287240469269,0.562734073360819,1.16757720205757,0.776566961802672,1.75546551658604]
["  HDL-C",45,{"v":0.028309151730717,"d":"0.028"},0.122677582612971,0.81750079709997,-0.212138910190706,0.26875721365214,1.02871366387654,0.808852331930633,1.30833745601052]
["  LDL-C",22,{"v":-0.20061250602978,"d":"-0.201"},0.227949334885563,0.378818692870492,-0.647393202405482,0.246168190345923,0.818229429102608,0.523408419731673,1.27911469019318]
["  Apolipoprotein A-I",35,{"v":0.0507545953085894,"d":"0.051"},{"v":0.111195181359801,"d":"0.111"},0.648069296541586,-0.167187960156621,0.2686971507738,1.05206467999299,0.846040574472474,1.30825887585697]
["Glucose metabolism"]
["  Fasting glucose",40,{"v":0.287249783274531,"d":"0.287"},0.372224790311774,0.440285903686881,-0.442310805736546,1.01681037228561,1.33275707232834,0.642549896223326,2.76436339696155]
["  Fasting insulin",20,{"v":0.222015931026355,"d":"0.222"},0.517400581709075,0.667851378561381,-0.792089209123431,1.23612107117614,1.24859126904625,0.452897608375717,3.44223534924307]
["  HbA1c",39,{"v":-0.223275564836668,"d":"-0.223"},0.532558285317664,0.675032742775807,-1.26708980405929,0.820538674385953,0.799894396152755,0.281650087193819,2.27172322711293]
["  Type 2 diabetes ",24,{"v":-0.0916801916659659,"d":"-0.092"},0.0893347662515088,0.304771713089337,-0.266776333518923,0.0834159501869913,0.912396895022261,0.765844346020398,1.08699384982349]
["Obesity traits"]
["  Body mass index",225,{"v":0.140451237796335,"d":"0.140"},0.432122650103786,0.745161146426527,-0.706509156407086,0.987411631999756,1.15079296299584,0.493363449531804,2.68427757454977]
["  Whole body fat mass",171,{"v":-0.140336922535919,"d":"-0.140"},0.84414583453863,0.867962377635903,-1.79486275823163,1.5141889131598,0.869065378355353,0.166150253536769,4.54573264727994]
["  Waist circumference",147,{"v":0.456071563174352,"d":"0.456"},0.968823242781866,0.637820732472939,-1.4428219926781,2.35496511902681,1.57786325762964,0.236260092799085,10.5377612879159]
["  Hip circumference",167,{"v":0.0185567862024905,"d":"0.019"},0.691474493691737,0.978590105200601,-1.33673322143331,1.37384679383829,1.01873003333703,0.26270245910873,3.95051833296056]
["  Waist-to-hip ratio",8,{"v":-0.213925036142718,"d":"-0.214"},0.401796461430662,0.594434163977821,-1.00144610054682,0.57359602826138,0.807408909240329,0.367347834981045,1.77463723654257]
[]
[]
[]
["AIH"]
["Exposure","nsnp","b","se","pval","lo_ci","up_ci","or","or_lci95","or_uci95"]
["Lipid metabolism"]
["  Triglyceride",56,{"v":-0.123206071046291,"d":"-0.123"},0.160175330634473,0.441777530055402,-0.437149719089858,0.190737576997277,0.884081460196641,0.645874724395463,1.21014184135321]
["  HDL-C",74,{"v":-0.0841229206855454,"d":"-0.084"},0.149865891623694,0.574578507453072,-0.377860068267986,0.209614226896895,0.9193182459206,0.685326392865682,1.23320223193005]
["  LDL-C",43,{"v":-0.108305114956037,"d":"-0.108"},0.160457161119559,0.4996894998477,-0.422801150750373,0.206190920838299,0.897353758603945,0.655208907958546,1.228987820983]
["  Apolipoprotein A-I",60,{"v":-0.139188911882219,"d":"-0.139"},{"v":0.144195159880073,"d":"0.144"},0.334403864306251,-0.421811425247162,0.143433601482724,0.870063647570676,0.655857705937675,1.15423016909087]
["Glucose metabolism"]
["  Fasting glucose",55,{"v":0.207207769252152,"d":"0.207"},0.371969393083837,0.577489192449631,-0.521852241192168,0.936267779696472,1.23023815088967,0.593420371732067,2.55044481113262]
["  Fasting insulin",26,{"v":0.742250056575598,"d":"0.742"},0.538544525040171,0.168125504389104,-0.313297212503136,1.79779732565433,2.1006567975659,0.73103260824633,6.03633672613534]
["  HbA1c",60,{"v":-0.727354314345485,"d":"-0.727"},0.486311745651284,0.134743732515657,-1.680525335822,0.225816707131032,0.483185657878206,0.186276092826538,1.25334591485448]
["  Type 2 diabetes ",48,{"v":-0.0771333371288209,"d":"-0.077"},0.0892855970980783,0.387645843137776,-0.252133107441054,0.0978664331834125,0.925766406342046,0.777141287895936,1.10281547571853]
["Obesity traits"]
["  Body mass index",367,{"v":0.683611569879492,"d":"0.684"},0.650911677029686,0.293609131858669,-0.592175317098692,1.95939845685768,1.98101941818023,0.553122757702862,7.09505779784845]
["  Whole body fat mass",264,{"v":0.26272752028501,"d":"0.263"},1.22086958573209,0.829613699111698,-2.13017686774988,2.6556319083199,1.30047231834377,0.118816277226281,14.2339777870464]
["  Waist circumference",231,{"v":0.0168434967898876,"d":"0.017"},1.42771877032496,0.990587183849593,-2.78148529304704,2.81517228662682,1.0169861482731,0.0619464304112681,16.6960520390407]
["  Hip circumference",247,{"v":-0.829318371734935,"d":"-0.829"},0.977609345650671,0.396263876135364,-2.74543268921025,1.08679594574038,0.436346611161049,0.064220507411322,2.96475958765416]
["  Waist-to-hip ratio",10,{"v":0.233154977891311,"d":"0.233"},0.574229366979596,0.684719754127807,-0.892334581388697,1.35864453717132,1.26257713570777,0.409698161696864,3.89091573418267]
[]
[]
[]
["PSC"]
["Exposure","nsnp","b","se","pval","lo_ci","up_ci","or","or_lci95","or_uci95"]
["Lipid metabolism"]
["  Triglyceride",42,-0.485171142278355,0.213227525110652,0.228838478964177,-0.903097091495233,-0.0672451930614776,0.615591833959526,0.405312424196899,0.934965926071782]
["  HDL-C",58,{"v":-0.230823155887563,"d":"-0.231"},0.190403503344373,0.225403615576109,-0.604014022442535,0.142367710667408,0.793879846598992,0.546613109289943,1.15300054119583]
["  LDL-C",35,{"v":0.0136629099702196,"d":"0.014"},0.246941156721034,0.955876672757364,-0.470341757203007,0.497667577143446,1.01375667406814,0.624788705750965,1.64488023672331]
["  Apolipoprotein A-I",47,{"v":-0.157437254579376,"d":"-0.157"},{"v":0.188814650941256,"d":"0.189"},0.404382953671131,-0.527513970424238,0.212639461265486,0.854330417248153,0.590070079439942,1.23693860656036]
["Glucose metabolism"]
["  Fasting glucose",47,{"v":0.0268454991856144,"d":"0.027"},0.387262208874193,0.94473391385895,-0.732188430207804,0.785879428579033,1.02720908586255,0.48085551904325,2.19433585410022]
["  Fasting insulin",24,{"v":-0.322403680414895,"d":"-0.322"},0.530939260618442,0.543696494515676,-1.36304463122704,0.718237270397251,0.724405702903451,0.255880527925292,2.05081499031554]
["  HbA1c",49,-0.99693963873072,0.501519309433729,0.0468294997627227,-1.97991748522083,-0.0139617922406112,0.369007009668397,0.138080630533568,0.986135221560345]
["  Type 2 diabetes ",33,{"v":-0.130311943066345,"d":"-0.130"},0.0916203797591589,0.154938301802316,-0.309887887394296,0.0492640012616067,0.877821557857919,0.733529189483303,1.05049764683924]
["Obesity traits"]
["  Body mass index",338,{"v":-0.27087729490574,"d":"-0.271"},0.406298295965474,0.504966576203612,-1.06722195499807,0.52546736518659,0.762710079075559,0.34396273533261,1.6912490946466]
["  Whole body fat mass",244,{"v":0.208483082056875,"d":"0.208"},0.747694139463113,0.780371672102249,-1.25699743129083,1.67396359540458,1.23180809022545,0.284506997114585,5.33326486354834]
["  Waist circumference",215,{"v":-0.622313829454555,"d":"-0.622"},0.885006356752421,0.481947059987235,-2.3569262886893,1.11229862978019,0.536701164825318,0.0947108901886662,3.04134128346861]
["  Hip circumference",231,{"v":0.561866221664596,"d":"0.562"},0.623363558397951,0.367404407187761,-0.659926352795387,1.78365879612458,1.75394269374759,0.516889400549397,5.95159229359462]
["  Waist-to-hip ratio",9,{"v":0.113485760166712,"d":"0.113"},0.361952711507106,0.753872310041912,-0.595941554387216,0.822913074720639,1.1201759376602,0.551043484124308,2.27712361630947]