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{"sheet":"SupplementaryTable1","index":0,"n_rows":56,"n_cols":49,"rows_kept":56,"merged":[[0,0,1,0],[0,1,0,4],[0,5,0,8],[0,9,0,11],[0,12,0,26],[0,28,0,45],[0,46,0,50]],"flags":["formulas_cached_only"]}
["Patient ID","Basic information",{"$nulls":3},"Comorbidity",{"$nulls":3},"Tumor treatment",null,null,"irAEs Characteristics",{"$nulls":33},"Clinical outcomes"]
[null,"Age","Gender","Cancer type","Tumor stage","HBP","DM","CAD","AD","ICI type","Regimen","Treatment line","Time to irAEs onset from ICI therapy initiation(days)","Doses of ICI","Heart","Muscle","Liver","Thyroid","Lung","Nerve","Skin","Bone marrow","Vessel","Adrenal gland","CMR","Biopsy site","EMG/NCS","Initial dose of corticorsteroid","Dosage of Tofacitinib","Time to steroid initiation from irAEs onset(days)","Time to tofacitinib initiation from irAEs onset(days)","Duration of steroids(days)","Duration of tofacitinib(days)","IVIG","Tocilizumab","Abatacept","CyclosporineA","Hydroxychloroquine","Tacrolimus","Mycophenolate mofetil","Plasmapheresis","Infectious adverse events ","Group","Outcome of irAEs","Progression status","Survival status","PFS(months)","OS(months)","Cause of death"]
["P01",45,"F","Others","IV",0,0,0,0,"anti-PD-1","ICI+chemotherapy",1,237,12,"G3",null,null,"G2",{"$nulls":6},1,"NA",0,"10-20mg/day","5mg bid",81,144,124,61,"20g qd*5d",0,0,0,0,0,0,0,0,"Steroid Resistance","Clinical Remission",1,1,{"v":16.0333333333333,"d":"16.0"},{"v":35.3666666666667,"d":"35.4"},"Tumor Progression"]
["P02",69,"F","Colorectal","IV",0,0,0,0,"anti-PD-1","ICI+targeted therapy","3 or more",32,1,"G5",null,"G3","G1","G3",{"$nulls":5},1,"NA",0,"500-1000mg/day","5mg qd",81,84,6,3,"20g qd*5d",0,0,0,0,0,0,0,0,"Life-threatening Consequence","Clinical Failure",1,1,{"v":3.96666666666667,"d":"4.0"},{"v":3.96666666666667,"d":"4.0"},"IrAE Related"]
["P03",71,"M","Gastric","III",0,0,0,0,"anti-PD-1","ICI+chemotherapy","neoadjuvant",42,2,"G3","G4","G1",null,null,"G2",{"$nulls":4},1,"NA",0,"500-1000mg/day","5mg qd",0,13,57,44,"20g qd*3d",0,0,0,0,0,0,0,0,"Steroid Resistance","Clinical Remission",0,0,{"v":50.6333333333333,"d":"50.6"},{"v":50.6333333333333,"d":"50.6"},"NA"]
["P04",71,"M","Gastric","IV",0,0,0,0,"anti-PD-1","ICI alone","3 or more",59,2,"G3",{"$nulls":9},1,"NA",0,"1-2mg/kg/day","5mg bid",2,20,121,103,0,0,0,0,0,0,0,0,0,"Steroid Resistance","Clinical Remission",1,1,{"v":1.76666666666667,"d":"1.8"},21.6,"Tumor Progression"]
["P05",69,"F","Others","IV",1,1,0,0,"anti-PD-1","ICI alone",2,17,1,"G4","G3","G3","G1",{"$nulls":6},1,"NA",0,"500-1000mg/day","5mg bid",4,8,62,58,0,0,0,0,0,0,0,1,1,"Life-threatening Consequence","Clinical Remission",1,1,3.1,3.1,"Infection"]
["P06",63,"F","Gastric","IV",0,0,0,0,"anti-PD-1","ICI+targeted therapy","3 or more",35,3,"G3","G3","G1",{"$nulls":7},1,"NA",0,"500-1000mg/day","5mg bid",5,18,79,73,"20g qd*3d",0,0,0,0,0,0,0,0,"Steroid Resistance","Clinical Remission",1,1,{"v":6.26666666666667,"d":"6.3"},7.8,"Tumor Progression"]
["P07",63,"F","Melanoma","III",0,0,0,0,"anti-PD-1","ICI alone","adjuvant",49,2,"G3","G4","G1",{"$nulls":7},1,"NA",0,"0.5-1mg/kg/day","5mg qd",0,25,63,38,0,0,0,0,0,0,0,0,0,"Steroid Resistance","Clinical Remission",0,0,{"v":45.7333333333333,"d":"45.7"},{"v":45.7333333333333,"d":"45.7"},"NA"]
["P08",60,"M","Esophageal","IV",0,0,0,0,"anti-PD-L1+anti-CTLA-4","ICI alone",2,28,4,"G3","G2",{"$nulls":8},1,"NA",0,"2-4mg/kg/day","5mg qd",16,29,96,82,"10g qd*3d",0,0,0,0,0,0,0,1,"Steroid taper failure","Clinical Remission",1,1,5.6,{"v":24.6666666666667,"d":"24.7"},"Tumor Progression"]
["P09",53,"M","Hepatic","IV",0,0,0,0,"anti-PD-1","ICI+targeted therapy",1,72,2,"G2","G1",{"$nulls":8},1,"NA",0,"0.5-1mg/kg/day","5mg bid",22,30,77,113,0,0,0,0,0,0,0,0,0,"Steroid taper failure","Clinical Remission",1,0,{"v":11.8666666666667,"d":"11.9"},41.7,"NA"]
["P10",76,"M","Colorectal","IV",1,1,0,0,"anti-PD-1","ICI+targeted therapy","3 or more",19,1,"G5","G4","G3",{"$nulls":7},0,"NA",0,"500-1000mg/day","5mg tid",0,3,25,22,"20g qd*5d",0,0,0,0,0,0,0,0,"Life-threatening Consequence","Clinical Failure",1,1,{"v":1.46666666666667,"d":"1.5"},{"v":1.46666666666667,"d":"1.5"},"IrAE Related"]
["P11",66,"M","Hepatic","IV",0,0,0,0,"anti-PD-1","ICI+targeted therapy",1,23,1,"G3","G1",{"$nulls":8},1,"NA",0,"1-2mg/kg/day","5mg bid",2,10,71,63,0,0,0,0,0,0,0,0,0,"Steroid Resistance","Clinical Remission",1,0,3.2,{"v":36.7666666666667,"d":"36.8"},"NA"]
["P12",82,"M","Gastric","IV",1,0,1,0,"anti-PD-1","ICI+chemotherapy",1,439,3,"G3",{"$nulls":9},1,"NA",0,"1-2mg/kg/day","5mg qd",5,8,59,56,"20g qd*3d",0,0,0,0,0,0,0,0,"Steroid Resistance","Clinical Remission",1,1,{"v":17.4666666666667,"d":"17.5"},{"v":26.9333333333333,"d":"26.9"},"Tumor Progression"]
["P13",73,"F","Gastric","IV",1,1,0,0,"anti-PD-1","ICI+chemotherapy",2,20,1,"G3","G2","G1",{"$nulls":7},0,"NA",0,"1-2mg/kg/day","5mg bid",0,37,135,84,"10g qd*3d",0,0,0,0,0,"0.5g bid*10d",0,0,"Steroid taper failure","Clinical Remission",1,1,{"v":9.23333333333333,"d":"9.2"},{"v":20.3666666666667,"d":"20.4"},"Tumor Progression"]
["P14",62,"F","Gastric","IV",1,0,0,0,"anti-PD-1","ICI+chemotherapy",1,43,2,"G3","G4","G2",{"$nulls":7},1,"NA",0,"2-4mg/kg/day","5mg bid",14,30,146,130,"10g qd*3d",0,0,0,0,0,0,0,0,"Steroid taper failure","Clinical Remission",1,1,{"v":20.7666666666667,"d":"20.8"},{"v":20.7666666666667,"d":"20.8"},"Tumor Progression"]
["P15",62,"F","Gastric","IV",0,1,0,0,"anti-PD-1","ICI alone",1,30,2,"G4","G4","G2",{"$nulls":7},1,"NA",0,"500-1000mg/day","5mg bid",5,10,59,37,"20g qd*3d",0,0,0,0,0,0,0,0,"Life-threatening Consequence","Clinical Remission",0,0,35.2,35.2,"NA"]
["P16",74,"M","Colorectal","IV",1,0,0,0,"anti-PD-1","ICI+targeted therapy+chemotherapy","3 or more",23,1,"G3",{"$nulls":9},0,"NA",0,"1-2mg/kg/day","5mg qd",2,6,40,36,"15g qd*3d",0,0,0,0,0,0,0,1,"Steroid Resistance","Clinical Remission",1,1,2.8,2.8,"Infection"]
["P17",58,"M","Pulmonary","III",0,0,0,0,"anti-PD-1","ICI+chemotherapy",1,17,1,null,null,"G4",{"$nulls":7},0,"liver",0,"1-2mg/kg/day","5mg bid",24,26,72,69,"20g qd*3d",0,0,0,0,0,0,1,0,"Life-threatening Consequence","Clinical Remission",1,1,{"v":4,"d":"4.0"},{"v":12.8666666666667,"d":"12.9"},"Tumor Progression"]
["P18",68,"M","Pulmonary","IV",1,0,1,0,"anti-PD-1","ICI+chemotherapy",1,44,2,"G3",{"$nulls":9},0,"NA",0,"2-4mg/kg/day","5mg bid",4,10,86,80,"20g qd*3d",0,0,0,0,0,0,0,0,"Steroid Resistance","Clinical Remission",1,1,{"v":7.96666666666667,"d":"8.0"},{"v":15.1333333333333,"d":"15.1"},"Tumor Progression"]
["P19",58,"F","Gallbladder","IV",0,0,0,0,"anti-PD-1","ICI+targeted therapy+chemotherapy",1,40,2,"G3","G3",{"$nulls":3},"G2",{"$nulls":4},0,"NA",1,"1-2mg/kg/day","5mg bid",42,92,110,60,"10g qd*3d",0,0,0,0,0,0,0,0,"Steroid taper failure","Clinical Remission",1,1,{"v":5,"d":"5.0"},6.4,"Tumor Progression"]
["P20",54,"M","Colorectal","IV",1,0,0,0,"anti-PD-1","ICI+targeted therapy","3 or more",54,3,"G3",null,"G3",{"$nulls":7},1,"liver",0,"500-1000mg/day","5mg bid",0,52,73,21,"20g qd*3d",0,0,0,0,0,0,0,1,"Steroid Resistance","Clinical Failure",1,1,{"v":3.23333333333333,"d":"3.2"},{"v":4.23333333333333,"d":"4.2"},"Tumor Progression"]
["P21",58,"M","Gastric","IV",0,0,0,0,"anti-PD-1","ICI+targeted therapy",1,13,1,"G5","G4",{"$nulls":8},1,"NA",0,"500-1000mg/day","5mg bid",9,16,36,29,"20g qd*3d",0,0,0,0,0,0,0,0,"Life-threatening Consequence","Clinical Failure",1,1,{"v":1.93333333333333,"d":"1.9"},{"v":1.93333333333333,"d":"1.9"},"IrAE Related"]
["P22",66,"M","Gastric","IV",1,0,1,0,"anti-PD-1","ICI+targeted therapy","3 or more",41,2,"G3","G1","G1",{"$nulls":7},1,"NA",0,"0.5-1mg/kg/day","5mg bid",3,9,55,49,0,0,0,0,0,0,0,0,0,"Steroid Resistance","Clinical Remission",1,1,3.3,13.7,"Tumor Progression"]
["P23",71,"M","Renal","IV",0,1,0,0,"anti-PD-L1","ICI alone","3 or more",77,4,"G4","G3",null,"G2",null,"G2",{"$nulls":4},1,"NA",1,"500-1000mg/day","5mg bid",0,6,88,82,"20g qd*5d",0,0,0,0,0,0,0,0,"Life-threatening Consequence","Clinical Remission",0,0,{"v":35.2333333333333,"d":"35.2"},{"v":35.2333333333333,"d":"35.2"},"NA"]
["P24",41,"F","Others","IV",0,0,0,0,"anti-PD-1","ICI+chemotherapy",1,21,1,{"$nulls":4},"G3",{"$nulls":5},0,"NA",0,"0.5-1mg/kg/day","5mg bid",6,83,118,14,0,0,0,0,0,0,0,0,0,"Steroid taper failure","Clinical Remission",1,1,0.9,{"v":7.66666666666667,"d":"7.7"},"Tumor Progression"]
["P25",58,"F","Pulmonary","IV",1,1,0,0,"anti-PD-1","ICI+chemotherapy",1,34,1,"G3","G2","G3",{"$nulls":7},0,"NA",1,"1-2mg/kg/day","5mg bid",2,9,117,110,0,0,0,0,0,0,0,0,0,"Steroid Resistance","Clinical Remission",1,1,17.7,{"v":30.8666666666667,"d":"30.9"},"Tumor Progression"]
["P26",74,"M","Hepatic","IV",1,0,0,0,"anti-PD-1","ICI+targeted therapy",1,41,2,"G4","G3","G2",null,null,"G2",{"$nulls":4},0,"NA",0,"500-1000mg/day","5mg bid",5,5,92,92,0,0,0,0,0,0,0,0,0,"Life-threatening Consequence","Clinical Remission",1,1,{"v":4.46666666666667,"d":"4.5"},{"v":6.56666666666667,"d":"6.6"},"Tumor Progression"]
["P27",66,"F","Gastric","IV",0,0,0,0,"anti-PD-1","ICI+chemotherapy",1,126,5,"G3",{"$nulls":9},1,"NA",0,"10-20mg/day","5mg bid",6,9,72,69,"20g qd*3d",0,0,0,0,0,0,0,0,"Steroid Resistance","Clinical Remission",1,1,{"v":4,"d":"4.0"},6.8,"Others"]
["P28",66,"F","Gastric","IV",0,0,0,0,"anti-PD-1","ICI+targeted therapy+chemotherapy",1,73,3,"G2",{"$nulls":9},1,"NA",0,"0.5-1mg/kg/day","5mg bid",4,25,34,13,0,0,0,0,0,0,0,0,0,"Steroid Resistance","Clinical Remission",1,1,{"v":3.36666666666667,"d":"3.4"},{"v":4.26666666666667,"d":"4.3"},"Tumor Progression"]
["P29",87,"M","Hepatic","IV",1,0,0,0,"anti-PD-1","ICI alone",2,33,2,"G3",{"$nulls":5},"G3",{"$nulls":3},1,"NA",0,"2-4mg/kg/day","5mg bid",2,28,158,132,"10g qd*3d",0,0,"50mg qd*14d",0,0,0,0,0,"Steroid Resistance","Clinical Remission",1,1,{"v":6.43333333333333,"d":"6.4"},{"v":6.66666666666667,"d":"6.7"},"Tumor Progression"]
["P30",58,"F","Gallbladder","IV",0,0,0,0,"anti-PD-1","ICI+targeted therapy+chemotherapy",2,17,1,"G3",{"$nulls":9},0,"NA",0,"2-4mg/kg/day","5mg bid",1,8,20,13,"20g qd*3d",0,0,0,0,0,0,0,0,"Steroid Resistance","Clinical Remission",1,1,{"v":0.533333333333333,"d":"0.5"},2.3,"Tumor Progression"]
["P31",77,"M","Gastric","IV",1,0,0,0,"anti-PD-1","ICI alone",1,11,1,null,null,"G4",{"$nulls":7},0,"NA",0,"1-2mg/kg/day","5mg bid",19,35,62,14,0,0,0,0,0,0,0,0,0,"Steroid Resistance","Clinical Remission",1,1,{"v":2.76666666666667,"d":"2.8"},3.1,"Tumor Progression"]
["P32",56,"F","Others","IV",1,0,0,0,"anti-PD-1","ICI+chemotherapy",1,237,10,{"$nulls":3},"G2","G3",{"$nulls":5},0,"NA",0,"1-2mg/kg/day","5mg bid",53,76,125,75,0,0,0,0,0,0,0,0,0,"Steroid taper failure","Clinical Remission",1,1,{"v":20.3666666666667,"d":"20.4"},{"v":36.0333333333333,"d":"36.0"},"Tumor Progression"]
["P33",58,"M","Hepatic","IV",1,1,1,0,"anti-PD-1","ICI+targeted therapy",1,34,2,"G2",{"$nulls":9},0,"NA",0,"10-20mg/day","5mg bid",10,13,16,13,0,0,0,0,0,0,0,0,0,"Steroid Resistance","Clinical Remission",1,0,1.5,{"v":26.8333333333333,"d":"26.8"},"NA"]
["P34",53,"M","Biliary","III",0,0,0,0,"anti-PD-L1","ICI+chemotherapy","adjuvant",22,2,"G2",null,null,"G2",{"$nulls":6},1,"NA",0,"10-20mg/day","5mg qd",21,24,22,19,0,0,0,0,0,0,0,0,0,"Steroid Resistance","Clinical Remission",0,0,28.8,28.8,"NA"]
["P35",67,"F","Others","IV",1,0,0,0,"anti-PD-1","ICI+targeted therapy+chemotherapy",1,102,8,"G2","G3",{"$nulls":4},"G3",{"$nulls":3},0,"NA",1,"2-4mg/kg/day","5mg bid",35,42,284,277,"20g qd*3d",0,0,0,0,0,0,0,0,"Steroid Resistance","Clinical Remission",1,1,8.3,16.9,"Tumor Progression"]
["P36",58,"M","Gallbladder","III",1,0,0,0,"anti-PD-1","ICI+targeted therapy+chemotherapy",1,20,1,"G3","G2",{"$nulls":8},0,"NA",0,"2-4mg/kg/day","5mg bid",0,9,57,48,0,0,0,0,0,0,0,0,0,"Steroid Resistance","Clinical Remission",1,0,6.6,{"v":35,"d":"35.0"},"NA"]
["P37",71,"M","Gastric","IV",0,0,0,0,"anti-PD-1","ICI+targeted therapy+chemotherapy",1,429,11,"G3",{"$nulls":6},"G3",null,null,0,"bone marrow",0,"0.5-1mg/kg/day","5mg bid",2,9,51,44,"20g qd*3d",0,0,0,0,0,0,0,0,"Steroid Resistance","Clinical Remission",1,1,{"v":14.0666666666667,"d":"14.1"},{"v":16.0666666666667,"d":"16.1"},"Tumor Progression"]
["P38",82,"F","Biliary","IV",1,0,0,0,"anti-PD-1","ICI+targeted therapy",1,24,1,"G3","G2",{"$nulls":8},1,"NA",0,"0.5-1mg/kg/day","5mg qd",18,33,52,37,0,0,0,0,0,0,0,0,0,"Steroid taper failure","Clinical Remission",1,1,{"v":3.13333333333333,"d":"3.1"},3.7,"Tumor Progression"]
["P39",62,"M","Hepatic","IV",0,0,0,0,"anti-PD-1","ICI+targeted therapy",1,30,2,"G3","G3","G3",{"$nulls":7},1,"NA",0,"500-1000mg/day","5mg qd",8,17,78,69,"10g qd*3d",0,0,0,0,0,0,0,0,"Steroid Resistance","Clinical Remission",0,0,{"v":26.1666666666667,"d":"26.2"},{"v":26.1666666666667,"d":"26.2"},"NA"]
["P40",43,"M","Others","IV",1,0,0,0,"anti-PD-1","ICI+targeted therapy+chemotherapy",2,48,2,"G3","G1",{"$nulls":8},0,"NA",0,"1-2mg/kg/day","5mg bid",2,20,66,48,0,0,0,0,0,0,0,0,0,"Steroid taper failure","Clinical Remission",1,1,{"v":2.23333333333333,"d":"2.2"},{"v":3.86666666666667,"d":"3.9"},"Tumor Progression"]
["P41",72,"M","Pulmonary","IV",0,0,0,0,"anti-PD-1","ICI+chemotherapy",1,16,1,"G3",{"$nulls":9},0,"NA",0,"2-4mg/kg/day","5mg bid",2,11,122,113,0,0,0,0,0,0,0,0,0,"Steroid Resistance","Clinical Remission",1,1,4.3,{"v":5.46666666666667,"d":"5.5"},"Others"]
["P42",71,"M","Hepatic","IV",1,0,0,0,"anti-PD-1","ICI+targeted therapy",1,19,2,"G3","G2","G3",{"$nulls":7},0,"NA",0,"500-1000mg/day","5mg bid",17,98,130,186,0,0,0,0,0,0,0,0,0,"Steroid taper failure","Clinical Remission",0,0,24.3,24.3,"NA"]
["P43",67,"M","Pulmonary","IV",1,1,0,0,"anti-PD-1","ICI+chemotherapy",1,20,1,"G5",{"$nulls":9},0,"NA",0,"1-2mg/kg/day","5mg bid",0,2,33,31,0,0,0,0,0,0,0,0,0,"Life-threatening Consequence","Clinical Failure",1,1,{"v":1.76666666666667,"d":"1.8"},{"v":1.76666666666667,"d":"1.8"},"IrAE Related"]
["P44",68,"M","Pulmonary","IV",0,0,0,0,"anti-PD-1","ICI+chemotherapy",1,23,1,"G3","G1",{"$nulls":8},1,"NA",0,"2-4mg/kg/day","5mg bid",0,13,45,32,"20g qd*3d",0,0,0,0,0,0,0,0,"Steroid Resistance","Clinical Remission",1,1,{"v":1.56666666666667,"d":"1.6"},{"v":2.66666666666667,"d":"2.7"},"Tumor Progression"]
["P45",58,"M","Pulmonary","IV",0,0,0,0,"anti-PD-1","ICI+chemotherapy",1,399,19,{"$nulls":5},"G3","G3",null,"G3",null,0,"skin",1,"10-20mg/day","5mg qd",57,57,189,"NA",0,0,0,"50mg qd*116d","100mg bid*14d",0,0,0,0,"Steroid Resistance","Clinical Remission",0,0,53.5,53.5,"NA"]
["P46",66,"M","Pulmonary","IV",0,1,0,0,"anti-PD-L1","ICI+chemotherapy",1,21,1,"G3","G3","G3",{"$nulls":3},"G3",{"$nulls":3},1,"NA",0,"2-4mg/kg/day","5mg bid",0,12,119,7,"20g qd*3d",0,0,0,0,0,0,0,0,"Steroid Resistance","Clinical Remission",1,1,7.4,{"v":16.2666666666667,"d":"16.3"},"Tumor Progression"]
["P47",44,"F","Pulmonary","IV",0,0,0,0,"anti-PD-L1+anti-CTLA-4","ICI+chemotherapy",1,116,6,"G2","G3",{"$nulls":4},"G3",{"$nulls":3},1,"NA",1,"0.5-1mg/kg/day","5mg bid",2,43,162,121,0,0,0,0,"100mg bid*92d","0.5mg bid*7d",0,0,0,"Steroid Resistance","Clinical Remission",1,1,{"v":6.43333333333333,"d":"6.4"},{"v":11.3666666666667,"d":"11.4"},"Tumor Progression"]
["P48",64,"M","Pulmonary","IV",1,0,0,0,"anti-PD-L1+anti-TIGIT","ICI alone",1,28,1,"G2","G3","G2","G2",{"$nulls":3},"G4",null,"G2",0,"liver, bone marrow",0,"2-4mg/kg/day","5mg qd",0,186,233,47,"20g qd*5d",0,0,0,0,0,0,0,0,"Steroid taper failure","Clinical Remission",0,0,{"v":24.3666666666667,"d":"24.4"},{"v":24.3666666666667,"d":"24.4"},"NA"]
["P49",67,"M","Nasopharyngeal","IV",0,1,0,0,"anti-PD-1","ICI+chemotherapy",1,86,4,"G3",{"$nulls":9},0,"NA",0,"500-1000mg/day","5mg qd",1,7,22,16,"20g qd*3d",0,0,0,0,0,0,0,0,"Steroid Resistance","Clinical Remission",1,0,6.7,35.8,"NA"]
["P50",82,"M","Esophageal","IV",1,0,0,0,"anti-PD-1","ICI+chemotherapy",1,47,2,"G3","G2","G2",null,null,"G2",{"$nulls":4},0,"NA",0,"1-2mg/kg/day","5mg qd",0,6,42,61,"20g qd*3d",0,0,0,0,0,0,0,0,"Steroid Resistance","Clinical Remission",1,1,16.1,18.9,"Tumor Progression"]
["P51",73,"F","Others","IV",0,0,1,0,"anti-PD-1","ICI alone","3 or more",861,31,"G3",{"$nulls":9},0,"NA",0,"0.5-1mg/kg/day","5mg bid",0,21,63,92,0,0,0,0,0,0,0,0,0,"Steroid taper failure","Clinical Remission",1,1,{"v":32.9666666666667,"d":"33.0"},{"v":39.5333333333333,"d":"39.5"},"Tumor Progression"]
["P52",75,"M","Gastric","IV",1,1,1,0,"anti-PD-L1","ICI+chemotherapy",1,51,2,"G5","G4","G3",{"$nulls":7},0,"NA",1,"500-1000mg/day","5mg bid",10,12,14,12,"30g qd*5d","480mg*1",0,0,0,0,0,0,0,"Life-threatening Consequence","Clinical Failure",1,1,2.5,2.5,"IrAE Related"]
["P53",65,"F","Others","III",1,1,0,0,"anti-PD-1","ICI+chemotherapy",1,29,1,"G4","G4","G2",{"$nulls":7},0,"NA",0,"500-1000mg/day","5mg bid",2,4,70,14,"20g qd*3d","480mg*1","250mg qd*2d",0,0,0,0,0,0,"Life-threatening Consequence","Clinical Remission",1,1,2.6,{"v":13,"d":"13.0"},"Tumor Progression"]
["irAE, immune-related adverse event; HBP, hypertension; DM, diabetes mellitus; CAD, coronary atherosclerotic heart disease; AD, autoimmune diseases; ICI, immune checkpoint inhibitor; CT, chemotherapy; TT, targeted therapy; IVIG, intravenous immune globulin. "]