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["Supplementary Table S5. Horizontal pleiotropy assessment for nominally significant gene–cell type MR associations"]
["egger_intercept","se","pval","gene_cell"]
[0.00372184284823763,0.0550151487540802,0.956997408417577,"AC069513.4_Excitatory neurons"]
[0.0383090048131604,0.0605563791761314,0.640909471073905,"AC114765.1_Excitatory neurons"]
[-0.00200540888044904,0.200581597749712,0.993635306413833,"AC159540.1_Excitatory neurons"]
[0.232339105899423,0.0707589979189241,0.0815641127291343,"ACADM_Excitatory neurons"]
[-0.431324007705407,0.413670884393169,0.48670205833584,"ACSS2_Oligodendrocytes"]
[-0.0143449984023341,0.0268593569855558,0.616169682776043,"ACTR1B_Excitatory neurons"]
[-0.0222547591218065,0.0269481113754112,0.45530502583118,"ACTR1B_Oligodendrocytes"]
[0.0016242791972404,0.0374383106955721,0.967473641426354,"ADAL_Excitatory neurons"]
[-0.0273055888075467,0.0885431731749729,0.777961219369993,"ADAL_Inhibitory neurons"]
[-0.135517896809837,0.75990591864865,0.887649457332936,"ADAL_Oligodendrocyte precursor cell (OPC)"]
[0.00164623071292846,0.56343936474547,0.997934012976267,"ADAL_Oligodendrocytes"]
[-0.07677968350462,0.0874004504301211,0.541125452107211,"ADAM15_Oligodendrocytes"]
[-0.448195114814644,9.67205788695542,0.970520657893135,"ADAM32_Excitatory neurons"]
[-0.134429956392632,0.195558260199523,0.616608105353627,"AHI1_Oligodendrocytes"]
[-0.0377891547132825,0.0551276165357442,0.617443854038293,"ANAPC2_Oligodendrocytes"]
[-0.0423414012312437,0.177511104812021,0.826836475565831,"ANKRD36_Astrocytes"]
[-0.0141689905883418,0.0307651627243521,0.659085056443273,"ANKRD36_Excitatory neurons"]
[-0.0334535099111051,0.0420362840650746,0.462226667835826,"ANKRD36_Inhibitory neurons"]
[-0.0157774314576242,0.072490000851816,0.841665217342928,"ANKRD36_Oligodendrocyte precursor cell (OPC)"]
[-0.0188419001268841,0.0201588544421471,0.37002235964832,"ANKRD36_Oligodendrocytes"]
[-0.0623688209474018,0.0787684681820068,0.472786035463384,"ANKRD36B_Astrocytes"]
[-0.00947451999756705,0.17816289826099,0.966177073938147,"ANKRD36B_Endothelial cell (Endo)"]
[0.0283631336119916,0.0258022015538471,0.300191643515511,"ANKRD36B_Excitatory neurons"]
[-0.121976459038435,0.0542076060398898,0.0742608700682783,"ANKRD36B_Inhibitory neurons"]
[0.0101191993855638,0.0770393390529634,0.900619201386117,"ANKRD36B_Oligodendrocyte precursor cell (OPC)"]
[-0.00901094261865083,0.0390866069573573,0.85575522536998,"ANO7_Excitatory neurons"]
[0.0429126594354154,0.0662703606256217,0.63417065196978,"ARFIP1_Oligodendrocytes"]
[-0.0567107185371213,0.0391536907195701,0.243338124585172,"ARL17A_Oligodendrocytes"]
[0.058192716018832,0.153212229533477,0.76891485346698,"ARNT_Oligodendrocytes"]
[0.0908957314931774,0.305728954528895,0.794268454381952,"ARPC3_Excitatory neurons"]
[-0.0315273332285685,0.0662000041250333,0.717046337227778,"ASPN_Astrocytes"]
[0.0463091691001804,0.237718561353557,0.863539433365237,"ASPN_Excitatory neurons"]
[0.0490484856086032,0.254171286639586,0.878640606872418,"ASPN_Oligodendrocytes"]
[-0.107443528026089,0.198459320096715,0.642482623150679,"ASRGL1_Inhibitory neurons"]
[-0.0719380903498813,0.0997251867134498,0.545616737746525,"ASRGL1_Oligodendrocytes"]
[0.0730158489607305,0.11580263708294,0.641863992238558,"ATAD3C_Oligodendrocytes"]
[0.0207865612498143,0.103756700424593,0.874126302550508,"ATG7_Astrocytes"]
[0.146294045896274,0.174960262738307,0.55665690270549,"ATG7_Excitatory neurons"]
[-0.0125325428924507,0.217640590789973,0.963381538627439,"ATG7_Oligodendrocyte precursor cell (OPC)"]
[0.0154453095756315,0.0742814749473897,0.869487651076832,"ATG7_Oligodendrocytes"]
[-0.0761700243168601,0.092926199412755,0.498538692464487,"BLMH_Excitatory neurons"]
[0.0283911139101128,0.0405793713057968,0.611351903482347,"BOLA3_Excitatory neurons"]
[-0.0351611002018383,0.0617126766359788,0.670305112988234,"CBY1_Excitatory neurons"]
[-0.0645553187330245,0.0609286760793828,0.400412027416889,"CBY1_Oligodendrocytes"]
[0.0290995835305477,0.096999681001203,0.814454773266656,"CCDC125_Excitatory neurons"]
[0.0230016912641126,0.033003282010448,0.524214826583798,"CCDC163_Oligodendrocytes"]
[0.0672492150733776,0.0499347379820548,0.406612136894713,"CCDC58_Excitatory neurons"]
[0.0220649382858856,0.0443288651722712,0.667997710591646,"CCHCR1_Excitatory neurons"]
[-0.0218087354234025,0.0316478818051545,0.528646737651007,"CENPP_Astrocytes"]
[0.0516820538434933,0.244683103899165,0.867480767093987,"CENPP_Endothelial cell (Endo)"]
[-0.0470450451677117,0.0302696227805359,0.195105101266533,"CENPP_Oligodendrocyte precursor cell (OPC)"]
[-0.0216836441996432,0.0187783248987213,0.300392283649537,"CENPP_Oligodendrocytes"]
[0.043521219814395,0.176766453310535,0.846316140114024,"CENPP_Pericyte"]
[-0.0320534169674256,0.117390419445064,0.8104258646575,"CKAP2_Excitatory neurons"]
[-0.0966574985903043,0.185087492614586,0.69361407263155,"CKAP2_Inhibitory neurons"]
[0.103687172703528,0.304326051993466,0.79094965449769,"CKAP2_Oligodendrocyte precursor cell (OPC)"]
[0.0992935798909979,0.320750608738058,0.786166611000522,"CKMT1A_Inhibitory neurons"]
[-0.00707831820812379,0.132432378116279,0.966005944254032,"CLDN9_Excitatory neurons"]
[0.0138566669420769,0.0325471971223129,0.743761896634142,"CLNS1A_Excitatory neurons"]
[-0.129474111988381,0.140562278328862,0.454230141188247,"CPNE1_Excitatory neurons"]
[-0.0457706872355753,0.036459876834495,0.428222455825256,"CR1_Oligodendrocytes"]
[-0.0670335102088322,0.0655623308119568,0.381827309083889,"CRCP_Oligodendrocytes"]
[-0.00106761107950466,0.0297532726440538,0.973095611572306,"CSDC2_Astrocytes"]
[0.41766524410148,0.338410251771603,0.433509680449378,"CTB-127M13.1_Excitatory neurons"]
[0.0387821868854331,0.0309086749649458,0.42837986325311,"CTC-459F4.3_Excitatory neurons"]
[0.0405468186341618,0.0362347126936521,0.464284494076326,"CTC-459F4.3_Inhibitory neurons"]
[-0.112402251949361,0.100796942169898,0.465380331676723,"CTD-2192J16.17_Oligodendrocytes"]
[-0.00194309884340048,0.054620831634244,0.973856485542375,"CTD-3162L10.1_Oligodendrocytes"]
[0.0272848135887685,0.103200510732336,0.835451407379496,"CTSS_Excitatory neurons"]
[0.0370987205465317,0.0975626323137078,0.768671352645027,"CTSS_Inhibitory neurons"]
[0.187149143127023,0.793534877566141,0.852552436233258,"CYP2D6_Astrocytes"]
[-0.101160891179799,0.114466513296626,0.539233860139958,"DDHD1_Oligodendrocytes"]
[0.105368984908834,0.198841916490941,0.689780962439689,"DHRS7_Excitatory neurons"]
[-0.0340232981989391,0.041952378150595,0.476733800981438,"ECM2_Oligodendrocytes"]
[-0.0320600018044662,0.0780422791845783,0.721048988098671,"EFCAB5_Oligodendrocytes"]
[0.0338989124452497,0.0538287078252647,0.642212347902319,"EIF2AK3_Excitatory neurons"]
[-0.140989616024354,0.0923445443785729,0.369152884878166,"FAM177A1_Excitatory neurons"]
[-0.0267011034964389,0.0266622771572375,0.355268265031679,"FAM178B_Excitatory neurons"]
[0.0219239212720449,0.0340894251762905,0.555153980926658,"FAM221A_Oligodendrocytes"]
[0.0433569358092652,0.087432201953759,0.706928350966635,"FAM227A_Excitatory neurons"]
[-0.0835743620541167,0.0450291209929365,0.204591629760821,"FARP2_Excitatory neurons"]
[0.105719991047247,0.195969454808679,0.627028703156159,"FHOD1_Excitatory neurons"]
[0.053345696347106,0.0327357842820804,0.154312052891065,"FLOT1_Excitatory neurons"]
[0.0574467232103261,0.0551368930513439,0.37403998227685,"FLOT1_Inhibitory neurons"]
[0.00128307041387204,0.0228601463137924,0.960343468750376,"FOXN2_Oligodendrocytes"]
[-0.0392032534120752,0.0686879047392919,0.669829643812702,"FZD9_Oligodendrocyte precursor cell (OPC)"]
[-0.0365420506263098,0.0376004109237122,0.509086929661702,"GAS8_Astrocytes"]
[0.0912970461904534,0.0718785138740379,0.424594376305174,"GLIPR1L2_Oligodendrocyte precursor cell (OPC)"]
[-0.0737843958098374,0.0591073043832441,0.429972970285175,"GNMT_Excitatory neurons"]
[-0.037496539443995,0.0375133549907666,0.391187612427928,"GOLGA6L10_Excitatory neurons"]
[0.157281411057041,0.265748660799108,0.659790449872647,"GOLGA6L10_Inhibitory neurons"]
[-0.195375768189577,0.120339097885044,0.245955091303629,"GOLGA6L10_Oligodendrocyte precursor cell (OPC)"]
[0.12758231430647,0.275140778636544,0.723588053426852,"GOLGA6L4_Oligodendrocyte precursor cell (OPC)"]
[-0.109429000333416,0.155659776889155,0.609919311557547,"GSTO2_Oligodendrocytes"]
[0.0713791503770268,0.0534477086938763,0.313417524266962,"HLA-B_Oligodendrocyte precursor cell (OPC)"]
[-0.016053944590212,0.0187850887655586,0.431798383627054,"HLA-DMA_Excitatory neurons"]
[-0.0239451265581728,0.0189643164518611,0.242277861533533,"HLA-DMA_Oligodendrocytes"]
[0.0524004383136485,0.0647258767530265,0.463592564250528,"HLA-F_Excitatory neurons"]
[0.0754565349273171,0.0557792465215481,0.308765408954619,"HORMAD1_Excitatory neurons"]
[-0.0941476665576541,0.0951246791283412,0.503286164145041,"HSD17B1_Excitatory neurons"]
[-0.0334227526220847,0.040911376290911,0.563919160407082,"HSD17B13_Excitatory neurons"]
[-0.0628468986450247,0.0439307300554184,0.288834262298349,"HSD17B13_Oligodendrocytes"]
[-0.0224090844452735,0.0262166537283371,0.440854844576093,"ICA1L_Excitatory neurons"]
[-0.186354159582732,0.119641080133978,0.363342612955934,"IGHMBP2_Astrocytes"]
[0.0737949497934679,0.146846193630561,0.703544401203163,"IPP_Oligodendrocytes"]
[-0.0142846318980395,0.0376309851266166,0.729521716087513,"IQCH_Excitatory neurons"]
[-0.0801497829314557,0.11026745672536,0.599864793928215,"KIFC2_Inhibitory neurons"]
[-0.0623296561882608,0.0727654337999167,0.549079910121033,"KNOP1_Excitatory neurons"]
[-0.0250750407614654,0.0658161140506635,0.739875943684506,"KNOP1_Oligodendrocytes"]
[0.0126884428319456,0.0628421059653336,0.858661388407505,"KRTCAP3_Excitatory neurons"]
[-0.247496247351711,0.318614022745259,0.579558775358479,"LAMC1_Inhibitory neurons"]
[0.0111428166047718,0.0657088352625936,0.893060210300312,"LEKR1_Excitatory neurons"]
[-0.0222523937116829,0.0695762053024295,0.77007842356271,"LINC00839_Oligodendrocyte precursor cell (OPC)"]
[0.06380621280475,0.147173289014287,0.739567863711182,"LINC01125_Excitatory neurons"]
[0.0617879875139908,0.101760599739229,0.605477971453044,"LRRC8A_Oligodendrocytes"]
[-0.0810381964491991,0.0649498689443529,0.300660182516243,"MAP1LC3A_Excitatory neurons"]
[-0.0129247847306421,0.0714717784645353,0.865287968618708,"MAP1LC3A_Inhibitory neurons"]
[0.0137168057236859,0.0379860464014215,0.741955443146019,"MAP2K5_Excitatory neurons"]
[0.103169482450256,0.17905341693368,0.667219079853068,"MAP2K5_Inhibitory neurons"]
[-0.102023925202537,0.296842173557566,0.789247558540301,"MAP2K5_Oligodendrocyte precursor cell (OPC)"]
[0.100343348414814,0.0749519765129315,0.312529468454532,"MAP2K5_Oligodendrocytes"]
[-0.22563472548522,0.154816339712071,0.382838453766539,"MARK3_Astrocytes"]
[-0.187080559865617,0.121694431859782,0.264045076940045,"MARK3_Excitatory neurons"]
[-0.11521028314476,0.0777439058810965,0.234968698886456,"MARK3_Oligodendrocytes"]
[0.481322728213688,0.469657536965791,0.492191300669154,"METTL18_Excitatory neurons"]
[0.0633823725446542,0.118108288255138,0.686443718905346,"METTL18_Oligodendrocytes"]
[0.00917680780679604,0.0753738413309907,0.914226621714937,"MSH3_Excitatory neurons"]
[-0.0802590182572439,0.0858935941721144,0.5215808120686,"MTFR1_Oligodendrocytes"]
[0.00339570580222815,0.0340695905205471,0.936757166700872,"MYO1H_Excitatory neurons"]
[-0.0897401711818835,0.131373234450853,0.618480892841519,"NAGA_Excitatory neurons"]
[-0.0124509927300555,0.0508091242340667,0.847008512341404,"NPIPA5_Excitatory neurons"]
[-0.0363208519865813,0.134899372411767,0.832564476527319,"NUDT2_Astrocytes"]
[0.113207876111104,0.0676470418682898,0.342892303056713,"NUP43_Oligodendrocytes"]
[-0.032736389579669,0.305296384004015,0.921376684405775,"OGN_Excitatory neurons"]
[0.0405136653351724,0.166598252538197,0.848133510143942,"OGN_Oligodendrocytes"]
[-0.142345925850337,0.324045314529105,0.736502002368461,"ORC4_Excitatory neurons"]
[0.040197693535835,0.0358673503964112,0.463796647084491,"ORC4_Oligodendrocytes"]
[-0.0577024242640922,0.0862066387922792,0.572195827340441,"P2RY14_Excitatory neurons"]
[0.0802217013001872,0.0473562276164228,0.339489693717084,"PCBP2_Excitatory neurons"]
[0.00454518156166712,0.0664353934864549,0.94975997016285,"PCDHB9_Excitatory neurons"]
[-0.260743106184462,0.252228998062977,0.409874861365445,"PCNX4_Excitatory neurons"]
[-0.121632418330194,0.113107506253334,0.476890409382482,"PEAK1_Oligodendrocytes"]
[-0.0232723155524879,0.0734195403101121,0.781289703804968,"PKN2_Oligodendrocytes"]
[-0.10270707356453,0.150928046467963,0.619606368917573,"POLI_Excitatory neurons"]
[-0.24275948191561,1.75420050907191,0.912455790321202,"PRMT7_Oligodendrocytes"]
[0.117734301535913,0.159410267016465,0.595020539242072,"PRPF40B_Oligodendrocytes"]
[-0.0596012006077885,0.0577386987723217,0.410432639827486,"RAPH1_Astrocytes"]
[0.00155904420465425,0.0998604448832694,0.990061753277263,"RBBP5_Excitatory neurons"]
[-0.014511803587571,0.226998168861392,0.959356737600758,"RBM6_Oligodendrocytes"]
[-0.0212761843487766,0.147185756823527,0.89831520565856,"RBPMS2_Excitatory neurons"]
[-0.0778859009785649,0.116609137915325,0.625112616640861,"RFWD2_Oligodendrocytes"]
[-0.0125684657794427,0.06602722984802,0.880250293851416,"RGPD1_Inhibitory neurons"]
[-0.159528938091138,0.40957291091012,0.763545013920215,"RNF169_Oligodendrocytes"]
[-0.0383631207454457,0.0961864544893363,0.728564767928969,"RP11-142A5.1_Oligodendrocytes"]
[-0.0850537271419276,0.128050798055532,0.626746070406928,"RP11-307C19.2_Inhibitory neurons"]
[0.0193661882883769,0.0596044128229173,0.776086065738296,"RP11-307C19.2_Oligodendrocytes"]
[-0.00427208635448374,0.0708497949517788,0.961659653272632,"RP11-379B18.6_Oligodendrocyte precursor cell (OPC)"]
[0.0309977721979403,0.0322985052923577,0.381269256994927,"RP11-457M11.5_Oligodendrocytes"]
[0.0260078836112086,0.0353015613877051,0.514668327464564,"RP11-486O12.2_Oligodendrocytes"]
[0.127746399765782,0.0752343087055008,0.338836825580587,"RP11-499F3.2_Excitatory neurons"]
[0.00437553768324831,0.0240788710812294,0.87255453934495,"RP11-535M15.1_Excitatory neurons"]
[0.0202631110754023,0.0456359693997676,0.733977802014163,"RP11-535M15.1_Inhibitory neurons"]
[0.0446212387969901,0.0368183473659614,0.264855020087861,"RP11-734K23.9_Excitatory neurons"]
[-0.00753261928861731,0.231717162696307,0.977019572032524,"RP11-734K23.9_Inhibitory neurons"]
[0.0662575954584597,0.127118390861469,0.694113746865453,"RP11-886D15.1_Oligodendrocyte precursor cell (OPC)"]
[-0.062082816002786,0.0674760431589238,0.526485675365173,"RPUSD2_Excitatory neurons"]
[-0.0733832114983073,0.0988085885072729,0.593327197483732,"SFI1_Oligodendrocytes"]
[0.0292120364576987,0.0927775329094651,0.782680564100251,"SKAP1_Excitatory neurons"]
[-0.0261576931626628,0.0262220585279133,0.357014490592627,"SLC7A6OS_Excitatory neurons"]
[{"v":1.09196068608425e-05,"d":"1.09E-05"},0.247748511022101,0.999971940749105,"SLC7A6OS_Inhibitory neurons"]
[-0.201311754401584,0.161478284396767,0.430379562816635,"SMIM8_Excitatory neurons"]
[0.000934592043197826,0.0325902253753153,0.978495884611135,"SPATA7_Excitatory neurons"]
[0.0489556984771257,0.0445661500581879,0.470141480340129,"SPATA7_Oligodendrocytes"]
[0.00823321327791774,0.0323765613688314,0.841470621278106,"SRPRB_Oligodendrocytes"]
[-0.141192586954965,0.134934244668361,0.405207445513846,"SSH2_Oligodendrocytes"]
[0.0215169124697773,0.0287000585546004,0.507862292543311,"STK31_Oligodendrocytes"]
[0.0492483761612422,0.106805452616802,0.724948935983533,"TCTN3_Excitatory neurons"]
[0.016628661404423,0.0275959751621697,0.589293238132712,"TESK2_Astrocytes"]
[0.0720327431459103,0.151469660856338,0.666871039110694,"TIPIN_Excitatory neurons"]
[-0.030049811260437,0.0753471890257464,0.75841110365332,"TMC5_Inhibitory neurons"]
[-0.198016884919598,0.129685697049442,0.266339636192493,"TSPAN15_Oligodendrocytes"]
[0.0884440203197678,0.232366872072607,0.768467307846445,"TSPOAP1_Oligodendrocyte precursor cell (OPC)"]
[-0.0208039198598737,0.258540824269514,0.939731265625089,"UBA7_Astrocytes"]
[0.0927196550966803,0.344869317323659,0.832795747673335,"UHRF1BP1_Oligodendrocytes"]
[-0.0783158402435275,0.052871481527693,0.198627960088672,"WDR6_Excitatory neurons"]
[-0.0222424623402105,0.0345024020651373,0.532358620492805,"WDR6_Oligodendrocytes"]
[-0.175301730025116,0.413763221699357,0.744875231741429,"XRRA1_Astrocytes"]
[-0.107777902214315,0.28612767899085,0.77066366261464,"XRRA1_Endothelial cell (Endo)"]
[-0.196962569666794,0.476224669277716,0.750337988436628,"XRRA1_Excitatory neurons"]
[-0.220045303715575,0.520009382785452,0.745155964674546,"XRRA1_Inhibitory neurons"]
[-0.19510569268962,0.487207592814896,0.757511348203451,"XRRA1_Oligodendrocyte precursor cell (OPC)"]
[-0.186219075527125,0.448490417387395,0.749457079707826,"XRRA1_Oligodendrocytes"]
[-0.134897855668101,0.337085174702231,0.757658273618935,"XRRA1_Pericyte"]
[-0.056121505242545,0.0973189237721215,0.666988614296155,"ZKSCAN1_Astrocytes"]
[0.107310340361806,0.0731552313530831,0.238684663234176,"ZKSCAN8_Oligodendrocytes"]
[0.0998417251379647,0.0808313483615443,0.271632958037203,"ZNF257_Excitatory neurons"]
[0.0533928429517913,0.10217727451504,0.653404181088005,"ZNF257_Oligodendrocytes"]
[-0.173472541403354,0.102489266914086,0.339722305343789,"ZNF260_Excitatory neurons"]
[-0.0456902637145911,0.11658207901363,0.762211587850148,"ZNF429_Excitatory neurons"]
[-0.332404316602632,0.667520693295204,0.705868210441874,"ZNF429_Inhibitory neurons"]
[0.0721830330598993,0.089821444796438,0.569040716454468,"ZNF566_Excitatory neurons"]
[0.0654315025435425,0.054662163595859,0.443063735004246,"ZNF682_Excitatory neurons"]
[-0.103841126017143,0.194945317398593,0.688413350278428,"ZNF738_Inhibitory neurons"]
[0.00254459239960906,0.0442352623918049,0.959357946348338,"ZP3_Excitatory neurons"]
[0.100838665885731,0.0470633759014409,0.165406365667404,"ZSCAN23_Endothelial cell (Endo)"]
[-0.0565016920522221,0.0454207399853037,0.259906829939724,"ZSCAN23_Excitatory neurons"]
[-0.0147450603435049,0.0341781541313221,0.681234994093425,"ZSCAN23_Oligodendrocytes"]
[-0.00274941168070501,0.0517362340572857,0.959675999919087,"ZSCAN31_Astrocytes"]
[-0.149911201174226,0.0476697686259485,0.0162700741676767,"ZSCAN31_Inhibitory neurons"]

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