Ingenuity Canonical Pathways -log(B-H p-value) Ratio z-score Molecules Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses 9.79E+00 2.27E-01 3.9 "C1QA,C1QB,C1QC,C5AR1,CASP1,CLEC6A,IL1A,IL1B,MBL2,NLRP3,NOD2,OSM,PIK3R6,PLCG2,PRKCB,PRKCH,RNASEL,TLR1,TLR2,TLR7,TLR9,TNF" Phagosome Formation 8.84E+00 2.22E-01 NaN "C5AR1,FCER1G,FCGR1A,FCGR2B,Fcrls,ITGAM,ITGB2,MBL2,MRC1,MSR1,PIK3R6,PLCG2,PRKCB,PRKCH,RAC2,TLR1,Tlr13,TLR2,TLR7,TLR9" TREM1 Signaling 7.97E+00 2.83E-01 3.873 "CASP1,CCL2,FCGR2B,IL1B,Naip1 (includes others),NLRP3,NOD2,PLCG2,TLR1,Tlr13,TLR2,TLR7,TLR9,TNF,TYROBP" Communication between Innate and Adaptive Immune Cells 7.62E+00 3.64E-01 NaN "CCL3L3,CCL4,CD28,FCER1G,IL1A,IL1B,TLR1,Tlr13,TLR2,TLR7,TLR9,TNF" Granulocyte Adhesion and Diapedesis 7.54E+00 2.05E-01 NaN "C5AR1,CCL2,CCL3L3,CCL4,Ccl6,CLDN1,CSF3R,Cxcl11,CXCL3,IL1A,IL1B,ITGAL,ITGAM,ITGB2,MMP3,PF4,SELPLG,TNF" Neuroinflammation Signaling Pathway 6.21E+00 1.28E-01 3.578 "CASP1,CCL2,CD200R1,CSF1R,CYBB,GABRB3,IL1B,MMP3,NAIP,Naip1 (includes others),NCF1,NFATC2,NLRP3,PIK3R6,PLCG2,TICAM2,TLR1,Tlr13,TLR2,TLR7,TLR9,TNF,TREM2,TYROBP" Agranulocyte Adhesion and Diapedesis 5.85E+00 1.80E-01 NaN "C5AR1,CCL2,CCL3L3,CCL4,Ccl6,CLDN1,Cxcl11,CXCL3,IL1A,IL1B,ITGB2,MMP3,MYH1,PF4,SELPLG,TNF" Leukocyte Extravasation Signaling 5.77E+00 1.41E-01 3 "ARHGAP4,ARHGAP9,BTK,CLDN1,CYBB,ITGAL,ITGAM,ITGB2,MMP3,NCF1,NCF4,PIK3R6,PLCG2,PRKCB,PRKCH,RAC2,SELPLG,SPN,VAV1,VAV3" Differential Regulation of Cytokine Production in Intestinal Epithelial Cells by IL-17A and IL-17F 5.07E+00 8.33E-01 NaN "CCL2,CCL4,IL1A,IL1B,TNF" Crosstalk between Dendritic Cells and Natural Killer Cells 4.66E+00 2.38E-01 3.162 "CD28,CD69,CSF2RB,IL2RG,ITGAL,TLR7,TLR9,TNF,TREM2,TYROBP" Complement System 4.41E+00 3.68E-01 1.342 "C1QA,C1QB,C1QC,C5AR1,ITGAM,ITGB2,MBL2" Production of Nitric Oxide and Reactive Oxygen Species in Macrophages 3.96E+00 1.18E-01 3.873 "APOC2,APOE,CYBB,IRF8,LYZ,MAP3K5,MAP3K9,NCF1,NCF4,PIK3R6,PLCG2,PRKCB,PRKCH,PTPN6,RAC2,TLR2,TNF" Natural Killer Cell Signaling 3.74E+00 1.19E-01 3 "CD48,FCER1G,IL12RB2,ITGAL,LAIR1,LCP2,MAP3K5,MAP3K9,NFATC2,PIK3R6,PLCG2,PTPN6,RAC2,TYROBP,VAV1,VAV3" T Helper Cell Differentiation 3.68E+00 2.35E-01 NaN "CD28,FCER1G,ICOSLG/LOC102723996,IL10RA,IL12RB2,IL21R,IL2RG,TNF" B Cell Receptor Signaling 3.68E+00 1.11E-01 2.84 "BCL2A1,BLNK,BTK,FCGR2B,INPP5D,MAP3K5,MAP3K9,NFATC2,PIK3AP1,PIK3R6,PLCG2,PRKCB,PTPN6,PTPRC,RAC2,VAV1,VAV3" LXR/RXR Activation 3.55E+00 1.57E-01 -1 "APOC2,APOE,CCL2,CD14,CD36,IL1A,IL1B,LYZ,MLXIPL,MSR1,TNF" Differential Regulation of Cytokine Production in Macrophages and T Helper Cells by IL-17A and IL-17F 3.55E+00 6.67E-01 NaN "CCL2,CCL4,IL1B,TNF" Inflammasome pathway 3.55E+00 3.33E-01 2.449 "AIM2,CASP1,IL1B,NAIP,NLRP3,NOD2" Fc Epsilon RI Signaling 3.49E+00 1.41E-01 2.714 "BTK,FCER1G,INPP5D,LCP2,PIK3R6,PLCG2,PRKCB,PRKCH,RAC2,TNF,VAV1,VAV3" MSP-RON Signaling Pathway 3.10E+00 2.26E-01 NaN "CCL2,CSF2RB,ITGAM,ITGB2,PIK3R6,TLR2,TNF" Th1 Pathway 3.10E+00 1.52E-01 2.449 "CCR5,CD28,ICOSLG/LOC102723996,IL10RA,IL12RB2,ITGB2,NFATC2,PIK3R6,RUNX3,VAV1" Fcγ Receptor-mediated Phagocytosis in Macrophages and Monocytes 2.95E+00 1.33E-01 3.317 "FCGR1A,FYB1,INPP5D,LCP2,NCF1,PLD4,PRKCB,PRKCH,RAC2,VAV1,VAV3" Dendritic Cell Maturation 2.80E+00 1.11E-01 3.162 "FCER1G,FCGR1A,FCGR2B,IL1A,IL1B,IRF8,PIK3R6,PLCG2,TLR2,TLR9,TNF,TREM2,TYROBP" iCOS-iCOSL Signaling in T Helper Cells 2.78E+00 1.37E-01 2.121 "CD28,FCER1G,ICOSLG/LOC102723996,IL2RG,INPP5D,LCP2,NFATC2,PIK3R6,PTPRC,VAV1" PKCθ Signaling in T Lymphocytes 2.66E+00 1.13E-01 3.317 "CACNA1A,CD28,FCER1G,LCP2,MAP3K5,MAP3K9,NFATC2,PIK3R6,PLCG2,RAC2,VAV1,VAV3" Th2 Pathway 2.66E+00 1.32E-01 0.707 "CCR5,CD28,ICOSLG/LOC102723996,IL12RB2,IL2RG,ITGB2,NFATC2,PIK3R6,RUNX3,VAV1" Toll-like Receptor Signaling 2.63E+00 1.43E-01 2.646 "CD14,IL1A,IL1B,TICAM2,TLR1,TLR2,TLR7,TLR9,TNF" Th1 and Th2 Activation Pathway 2.52E+00 1.16E-01 NaN "CCR5,CD28,ICOSLG/LOC102723996,IL10RA,IL12RB2,IL2RG,ITGB2,NFATC2,PIK3R6,RUNX3,VAV1" IL-12 Signaling and Production in Macrophages 2.49E+00 1.23E-01 NaN "APOC2,APOE,IL12RB2,IRF8,LYZ,PIK3R6,PRKCB,PRKCH,TLR2,TNF" Cardiac Hypertrophy Signaling (Enhanced) 2.48E+00 7.08E-02 4.899 "AGTR1,ATP2A3,CACNA1A,CSF2RB,CYBB,GNA15,GNG2,IL10RA,IL12RB2,IL1A,IL1B,IL21R,IL2RG,IL7R,MAP3K5,MAP3K9,NFATC2,OSM,PIK3R6,PLCG2,PRKCB,PRKCH,TNF,WNT2B" PI3K Signaling in B Lymphocytes 2.45E+00 1.05E-01 2.309 "BLNK,BTK,CD180,FCGR2B,INPP5D,NFATC2,PIK3AP1,PLCG2,PRKCB,PTPRC,VAV1,VAV3" CCR5 Signaling in Macrophages 2.15E+00 1.33E-01 2.236 "CACNA1A,CCL4,CCR5,FCER1G,GNG2,PLCG2,PRKCB,PRKCH" STAT3 Pathway 2.14E+00 1.03E-01 1.89 "CSF2RB,IL10RA,IL12RB2,IL1A,IL1B,IL21R,IL2RG,IL7R,MAP3K9,PTPN6,TNFRSF11A" Tec Kinase Signaling 2.09E+00 9.52E-02 2.828 "BTK,FCER1G,GNA15,GNG2,PIK3R6,PLCG2,PRKCB,PRKCH,RAC2,TNF,VAV1,VAV3" Role of NFAT in Regulation of the Immune Response 2.04E+00 9.38E-02 3.317 "BLNK,BTK,CD28,FCER1G,FCGR1A,FCGR2B,GNA15,GNG2,LCP2,NFATC2,PIK3R6,PLCG2" Macropinocytosis Signaling 2.00E+00 1.25E-01 2.236 "CD14,CSF1R,ITGB2,MRC1,PIK3R6,PLCG2,PRKCB,PRKCH" FcγRIIB Signaling in B Lymphocytes 1.84E+00 1.32E-01 1.342 "BLNK,BTK,CACNA1A,FCGR2B,INPP5D,PIK3R6,PLCG2" Coagulation System 1.77E+00 2.35E-01 2 "F13A1,F5,F9,PLAU" NF-κB Signaling 1.74E+00 8.57E-02 3.464 "FCER1G,IL1A,IL1B,PIK3R6,PLCG2,PRKCB,TLR1,TLR2,TLR7,TLR9,TNF,TNFRSF11A" IL-10 Signaling 1.67E+00 1.21E-01 NaN "CCR5,CD14,FCGR2B,IL10RA,IL1A,IL1B,TNF" Gαq Signaling 1.67E+00 8.80E-02 3.162 "AGTR1,BTK,GNA15,GNG2,NFATC2,PIK3R6,PLCG2,PLD4,PRKCB,PRKCH,RAC2" Role of Cytokines in Mediating Communication between Immune Cells 1.59E+00 3.00E-01 NaN "IL1A,IL1B,TNF" B Cell Development 1.59E+00 3.00E-01 NaN "IL7R,PTPRC,SPN" T Cell Receptor Signaling 1.59E+00 1.04E-01 NaN "BTK,CD28,LCP2,NFATC2,PIK3R6,PTPRC,VAV1,VAV3" Eicosanoid Signaling 1.59E+00 1.56E-01 NaN "ALOX5,ALOX5AP,DPEP2,HPGDS,TBXAS1" FXR/RXR Activation 1.38E+00 1.18E-01 NaN "APOC2,APOE,IL1A,IL1B,MLXIPL,TNF" Calcium-induced T Lymphocyte Apoptosis 1.38E+00 1.39E-01 2 "ATP2A3,FCER1G,NFATC2,PRKCB,PRKCH" CD28 Signaling in T Helper Cells 1.38E+00 9.52E-02 1.89 "CD28,FCER1G,LCP2,NFATC2,PIK3R6,PTPN6,PTPRC,VAV1" GPCR-Mediated Nutrient Sensing in Enteroendocrine Cells 1.29E+00 1.00E-01 2.646 "CACNA1A,GNA15,GNG2,LPAR5,PLCG2,PRKCB,PRKCH" T Cell Exhaustion Signaling Pathway 1.29E+00 8.49E-02 1 "CD28,FCER1G,IL10RA,IL12RB2,NFATC2,PIK3R6,PLCG2,PRDM1,PTPN6" GP6 Signaling Pathway 1.28E+00 9.09E-02 2.828 "BTK,FCER1G,LAMC3,LCP2,PIK3R6,PLCG2,PRKCB,PRKCH" Th17 Activation Pathway 1.27E+00 1.28E-01 2.236 "FCER1G,IL12RB2,IL1B,IL21R,NFATC2" Serotonin Degradation 1.17E+00 1.48E-01 1 "DHRS9,MAOB,UGT1A4,Ugt1a7c" Intrinsic Prothrombin Activation Pathway 1.15E+00 2.00E-01 NaN "F13A1,F5,F9" Growth Hormone Signaling 1.10E+00 1.00E-01 0.816 "IGFBP3,PIK3R6,PLCG2,PRKCB,PRKCH,PTPN6" Phospholipase C Signaling 1.09E+00 6.74E-02 3 "BLNK,BTK,FCER1G,FCGR2B,GNG2,LCP2,NFATC2,PLCG2,PLD4,PRKCB,PRKCH,RAC2" Extrinsic Prothrombin Activation Pathway 1.08E+00 3.33E-01 NaN "F13A1,F5" Leukotriene Biosynthesis 1.08E+00 3.33E-01 NaN "ALOX5,DPEP2" IL-23 Signaling Pathway 1.06E+00 1.33E-01 2 "IL12RB2,IL1B,PIK3R6,TNF" Renin-Angiotensin Signaling 1.03E+00 7.92E-02 2.828 "AGTR1,CCL2,PIK3R6,PLCG2,PRKCB,PRKCH,PTPN6,TNF" Gα12/13 Signaling 1.03E+00 7.92E-02 2.121 "BTK,CDH13,CDH8,LPAR5,MAP3K5,PIK3R6,VAV1,VAV3" IL-8 Signaling 1.00E+00 6.71E-02 3.162 "ARRB2,CYBB,GNG2,ITGAM,ITGB2,NCF1,PIK3R6,PLD4,PRKCB,PRKCH,RAC2" Superpathway of Melatonin Degradation 9.87E-01 1.67E-01 NaN "MAOB,UGT1A4,Ugt1a7c" Apoptosis Signaling 9.87E-01 8.33E-02 -0.378 "BCL2A1,CAPN3,MAP3K5,NAIP,Naip1 (includes others),PLCG2,TNF" Xenobiotic Metabolism Signaling 9.14E-01 6.25E-02 NaN "IL1A,IL1B,MAOB,MAP3K5,MAP3K9,PIK3R6,PRKCB,PRKCH,SOD3,TNF,UGT1A4,Ugt1a7c" IL-3 Signaling 9.10E-01 8.70E-02 0.816 "CSF2RB,INPP5D,PIK3R6,PRKCB,PRKCH,PTPN6" Virus Entry via Endocytic Pathways 9.10E-01 7.95E-02 NaN "ITGAL,ITGB2,PIK3R6,PLCG2,PRKCB,PRKCH,RAC2" G Beta Gamma Signaling 9.10E-01 7.95E-02 2.646 "BTK,CACNA1A,GNA15,GNG2,PLCG2,PRKCB,PRKCH" NF-κB Activation by Viruses 8.93E-01 8.57E-02 2.236 "CCR5,ITGAL,ITGB2,PIK3R6,PRKCB,PRKCH" Role of JAK1 and JAK3 in γc Cytokine Signaling 8.66E-01 9.43E-02 NaN "BLNK,IL21R,IL2RG,IL7R,PIK3R6" Hematopoiesis from Pluripotent Stem Cells 8.24E-01 2.22E-01 NaN "FCER1G,IL1A" Prostanoid Biosynthesis 8.24E-01 2.22E-01 NaN "HPGDS,TBXAS1" fMLP Signaling in Neutrophils 7.93E-01 7.37E-02 2.646 "CYBB,GNG2,NCF1,NFATC2,PIK3R6,PRKCB,PRKCH" Gαi Signaling 7.52E-01 7.79E-02 2.449 "ADORA3,AGTR1,CNR2,GNG2,P2RY12,P2RY13" Thyroid Hormone Metabolism II (via Conjugation and/or Degradation) 7.50E-01 2.00E-01 NaN "UGT1A4,Ugt1a7c" Serotonin Receptor Signaling 7.35E-01 1.25E-01 NaN "MAOB,PCBD1,SLC6A4" CTLA4 Signaling in Cytotoxic T Lymphocytes 7.30E-01 8.47E-02 NaN "CD28,FCER1G,LCP2,PIK3R6,PTPN6" Gustation Pathway 7.24E-01 7.59E-02 NaN "CACNA1A,GNG2,P2RX1,P2RY12,P2RY13,P2RY6" p70S6K Signaling 6.99E-01 6.93E-02 2.646 "AGTR1,BTK,IL2RG,PIK3R6,PLCG2,PRKCB,PRKCH" Ephrin B Signaling 6.72E-01 8.06E-02 2 "GNA15,GNG2,RAC2,VAV1,VAV3" Chemokine Signaling 6.56E-01 7.94E-02 2.236 "CCL2,CCL4,CCR5,PLCG2,PRKCB" Acute Phase Response Signaling 6.48E-01 6.30E-02 2.236 "CRABP1,IL1A,IL1B,ITIH3,MAP3K5,MBL2,OSM,TNF" SAPK/JNK Signaling 6.48E-01 7.14E-02 2.449 "FCER1G,GNG2,MAP3K5,MAP3K9,PIK3R6,RAC2" P2Y Purigenic Receptor Signaling Pathway 6.42E-01 6.60E-02 1.89 "GNG2,P2RY12,P2RY6,PIK3R6,PLCG2,PRKCB,PRKCH" Xenobiotic Metabolism General Signaling Pathway 6.42E-01 6.60E-02 2.646 "MAP3K5,MAP3K9,PIK3R6,PRKCB,PRKCH,UGT1A4,Ugt1a7c" Alanine Degradation III 6.33E-01 5.00E-01 NaN GPT Alanine Biosynthesis II 6.33E-01 5.00E-01 NaN GPT Tryptophan Degradation to 2-amino-3-carboxymuconate Semialdehyde 6.33E-01 5.00E-01 NaN HAAO Glycine Degradation (Creatine Biosynthesis) 6.33E-01 5.00E-01 NaN GATM Tyrosine Biosynthesis IV 6.33E-01 5.00E-01 NaN PCBD1 IL-4 Signaling 6.33E-01 7.69E-02 NaN "IL2RG,INPP5D,NFATC2,PIK3R6,PTPN6" "PD-1, PD-L1 cancer immunotherapy pathway" 6.33E-01 7.58E-02 -1.342 "CD28,IL2RG,LCP2,PIK3R6,TNF" LPS/IL-1 Mediated Inhibition of RXR Function 6.31E-01 6.11E-02 0.447 "APOC2,APOE,CD14,IL1A,IL1B,MAOB,SOD3,TNF" Erythropoietin Signaling 6.29E-01 7.46E-02 NaN "PIK3R6,PLCG2,PRKCB,PRKCH,PTPN6" HMGB1 Signaling 6.29E-01 6.42E-02 2.449 "CCL2,IL1A,IL1B,OSM,PIK3R6,RAC2,TNF" TNFR2 Signaling 6.29E-01 1.03E-01 NaN "NAIP,Naip1 (includes others),TNF" nNOS Signaling in Neurons 6.29E-01 1.03E-01 NaN "CAPN3,PRKCB,PRKCH" IL-9 Signaling 5.99E-01 1.00E-01 NaN "IL2RG,PIK3R6,TNF" Regulation of IL-2 Expression in Activated and Anergic T Lymphocytes 5.44E-01 6.94E-02 NaN "CD28,NFATC2,PLCG2,VAV1,VAV3" Melatonin Degradation I 5.44E-01 1.33E-01 NaN "UGT1A4,Ugt1a7c" Nitric Oxide Signaling in the Cardiovascular System 5.44E-01 6.94E-02 1.342 "ATP2A3,CACNA1A,PIK3R6,PRKCB,PRKCH" VDR/RXR Activation 5.42E-01 7.69E-02 NaN "CD14,IGFBP3,PRKCB,PRKCH" LPS-stimulated MAPK Signaling 5.42E-01 6.85E-02 2 "CD14,MAP3K5,PIK3R6,PRKCB,PRKCH" Cholecystokinin/Gastrin-mediated Signaling 5.42E-01 6.25E-02 2.236 "IL1A,IL1B,PRKCB,PRKCH,RAC2,TNF" Nicotine Degradation III 5.42E-01 1.25E-01 NaN "UGT1A4,Ugt1a7c" Trehalose Degradation II (Trehalase) 5.42E-01 3.33E-01 NaN HK3 Melatonin Degradation II 5.42E-01 3.33E-01 NaN MAOB Phenylalanine Degradation I (Aerobic) 5.42E-01 3.33E-01 NaN PCBD1 PI3K/AKT Signaling 5.42E-01 5.67E-02 NaN "CSF2RB,IL10RA,IL12RB2,IL21R,IL2RG,IL7R,INPP5D,MAP3K5" Docosahexaenoic Acid (DHA) Signaling 5.32E-01 8.82E-02 NaN "BCL2A1,IL1B,PIK3R6" Apelin Cardiomyocyte Signaling Pathway 5.32E-01 6.67E-02 2.236 "ATP2A3,PIK3R6,PLCG2,PRKCB,PRKCH" Role of PKR in Interferon Induction and Antiviral Response 5.13E-01 6.06E-02 2.236 "CASP1,FCGR1A,IL1B,MSR1,TLR9,TNF" Thrombopoietin Signaling 5.13E-01 7.27E-02 2 "PIK3R6,PLCG2,PRKCB,PRKCH" HGF Signaling 5.13E-01 6.06E-02 2.449 "MAP3K5,MAP3K9,PIK3R6,PLCG2,PRKCB,PRKCH" ErbB4 Signaling 5.00E-01 7.14E-02 2 "PIK3R6,PLCG2,PRKCB,PRKCH" Oncostatin M Signaling 4.93E-01 8.33E-02 NaN "MMP3,OSM,PLAU" 14-3-3-mediated Signaling 4.62E-01 5.77E-02 2.449 "MAP3K5,PIK3R6,PLCG2,PRKCB,PRKCH,TNF" Caveolar-mediated Endocytosis Signaling 4.62E-01 6.78E-02 NaN "CD48,ITGAL,ITGAM,ITGB2" Nicotine Degradation II 4.62E-01 1.05E-01 NaN "UGT1A4,Ugt1a7c" Ceramide Degradation 4.62E-01 2.50E-01 NaN ACER2 Acetate Conversion to Acetyl-CoA 4.62E-01 2.50E-01 NaN ACSS1 Ethanol Degradation II 4.28E-01 1.00E-01 NaN "ACSS1,DHRS9" Reelin Signaling in Neurons 4.23E-01 5.56E-02 2.236 "APOE,CNR2,ITGAL,ITGB2,MAP3K9,PIK3R6" Endothelin-1 Signaling 4.23E-01 5.26E-02 2.646 "CASP1,GNA15,PIK3R6,PLCG2,PLD4,PRKCB,PRKCH" Agrin Interactions at Neuromuscular Junction 4.23E-01 6.45E-02 NaN "ITGAL,ITGB2,RAC2,RAPSN" VEGF Family Ligand-Receptor Interactions 4.23E-01 6.45E-02 2 "PIK3R6,PLCG2,PRKCB,PRKCH" Endocannabinoid Neuronal Synapse Pathway 4.23E-01 5.88E-02 2.236 "CACNA1A,CNR2,GNA15,GNG2,PLCG2" GM-CSF Signaling 4.23E-01 6.45E-02 2 "BCL2A1,CSF2RB,PIK3R6,PRKCB" Signaling by Rho Family GTPases 4.17E-01 4.89E-02 1.342 "CDH13,CDH8,CYBB,GNA15,GNG2,MAP3K9,NCF1,PIK3R6,RAC2" Noradrenaline and Adrenaline Degradation 4.17E-01 9.52E-02 NaN "DHRS9,MAOB" CXCR4 Signaling 4.16E-01 5.19E-02 2 "ELMO1,GNA15,GNG2,PIK3R6,PRKCB,PRKCH,RAC2" Sphingosine and Sphingosine-1-phosphate Metabolism 4.16E-01 2.00E-01 NaN ACER2 NAD biosynthesis II (from tryptophan) 4.16E-01 2.00E-01 NaN HAAO GNRH Signaling 4.10E-01 5.15E-02 2.449 "CACNA1A,GNA15,GNG2,MAP3K5,MAP3K9,PRKCB,PRKCH" Ephrin A Signaling 4.10E-01 7.14E-02 NaN "PIK3R6,VAV1,VAV3" nNOS Signaling in Skeletal Muscle Cells 4.03E-01 9.09E-02 NaN "CACNA1A,CAPN3" RhoGDI Signaling 4.00E-01 5.07E-02 -1 "ARHGAP4,ARHGAP9,CDH13,CDH8,GNA15,GNG2,RAC2" GDNF Family Ligand-Receptor Interactions 4.00E-01 6.15E-02 2 "DOK2,DOK3,PIK3R6,PLCG2" Netrin Signaling 4.00E-01 6.98E-02 NaN "CACNA1A,NFATC2,RAC2" Necroptosis Signaling Pathway 4.00E-01 5.31E-02 2.449 "CAPN3,CASP1,CYBB,MERTK,NLRP3,TNF" Germ Cell-Sertoli Cell Junction Signaling 3.81E-01 5.00E-02 NaN "LAMC3,MAP3K5,MAP3K9,MYO7A,PIK3R6,RAC2,TNF" RAR Activation 3.78E-01 4.82E-02 NaN "CRABP1,CSF2RB,DHRS9,IGFBP3,MAP3K5,PRKCB,PRKCH,ZBTB16" Calcium Transport I 3.74E-01 1.67E-01 NaN ATP2A3 Calcium Signaling 3.74E-01 5.17E-02 NaN "ATP2A3,CACNA1A,MYH1,NFATC2,TNNI2,TNNT1" G Protein Signaling Mediated by Tubby 3.70E-01 8.33E-02 NaN "GNG2,PLCG2" TNFR1 Signaling 3.65E-01 6.52E-02 NaN "NAIP,Naip1 (includes others),TNF" UVB-Induced MAPK Signaling 3.65E-01 6.52E-02 NaN "PIK3R6,PRKCB,PRKCH" Prolactin Signaling 3.54E-01 5.71E-02 2 "PIK3R6,PLCG2,PRKCB,PRKCH" Sphingosine-1-phosphate Signaling 3.37E-01 5.15E-02 NaN "ACER2,CASP1,PIK3R6,PLCG2,RAC2" Glucose and Glucose-1-phosphate Degradation 3.37E-01 1.43E-01 NaN HK3 Superoxide Radicals Degradation 3.37E-01 1.43E-01 NaN SOD3 GDP-glucose Biosynthesis 3.37E-01 1.43E-01 NaN HK3 Antioxidant Action of Vitamin C 3.37E-01 5.56E-02 -2 "CSF2RB,PLCG2,PLD4,TNF" Inhibition of Matrix Metalloproteases 3.37E-01 7.69E-02 NaN "MMP3,TFPI2" G-Protein Coupled Receptor Signaling 3.37E-01 4.60E-02 NaN "ADORA3,AGTR1,CNR2,GNA15,P2RY12,P2RY13,PIK3R6,PRKCB" CREB Signaling in Neurons 3.31E-01 4.70E-02 2 "CACNA1A,GNA15,GNG2,PIK3R6,PLCG2,PRKCB,PRKCH" Antiproliferative Role of TOB in T Cell Signaling 2.99E-01 7.14E-02 NaN "CD28,FCER1G" Actin Cytoskeleton Signaling 2.98E-01 4.58E-02 2.236 "CD14,MYH1,NCKAP1L,PIK3R6,RAC2,VAV1,VAV3" α-Adrenergic Signaling 2.86E-01 5.19E-02 NaN "GNG2,PLCG2,PRKCB,PRKCH" Synaptic Long Term Depression 2.78E-01 4.81E-02 2.236 "CACNA1A,GNA15,PLCG2,PRKCB,PRKCH" eNOS Signaling 2.78E-01 4.81E-02 2.236 "LPAR5,PIK3R6,PLCG2,PRKCB,PRKCH" ErbB Signaling 2.78E-01 5.13E-02 2 "PIK3R6,PLCG2,PRKCB,PRKCH" Antiproliferative Role of Somatostatin Receptor 2 2.77E-01 5.56E-02 NaN "GNG2,PIK3R6,PTPN6" PDGF Signaling 2.77E-01 5.06E-02 2 "INPP5D,PIK3R6,PLCG2,PRKCB" Phagosome Maturation 2.77E-01 4.76E-02 NaN "ATP6V1G2,CTSE,CTSS,CYBB,NCF1" Androgen Signaling 2.68E-01 4.72E-02 NaN "CACNA1A,GNA15,GNG2,PRKCB,PRKCH" Xenobiotic Metabolism CAR Signaling Pathway 2.60E-01 4.67E-02 -0.447 "PRKCB,PRKCH,SOD3,UGT1A4,Ugt1a7c" Melatonin Signaling 2.56E-01 5.36E-02 NaN "PLCG2,PRKCB,PRKCH" "Phenylalanine Degradation IV (Mammalian, via Side Chain)" 2.52E-01 1.00E-01 NaN MAOB UDP-N-acetyl-D-galactosamine Biosynthesis II 2.52E-01 1.00E-01 NaN HK3 IL-6 Signaling 2.52E-01 4.59E-02 2 "CD14,IL1A,IL1B,PIK3R6,TNF" Death Receptor Signaling 2.51E-01 4.82E-02 0 "MAP3K5,NAIP,Naip1 (includes others),TNF" VEGF Signaling 2.51E-01 4.82E-02 0 "PIK3R6,PLCG2,PRKCB,PTPN6" Thrombin Signaling 2.50E-01 4.27E-02 2 "GNA15,GNG2,PIK3R6,PLCG2,PRKCB,PRKCH,RAC2" Mechanisms of Viral Exit from Host Cells 2.48E-01 6.06E-02 NaN "PRKCB,PRKCH" OX40 Signaling Pathway 2.48E-01 6.06E-02 NaN "FCER1G,H2-M1/H2-M9" Clathrin-mediated Endocytosis Signaling 2.47E-01 4.35E-02 NaN "APOC2,APOE,ARRB2,ITGB2,LYZ,PIK3R6" Dopamine-DARPP32 Feedback in cAMP Signaling 2.47E-01 4.50E-02 2 "ATP2A3,CACNA1A,PLCG2,PRKCB,PRKCH" TWEAK Signaling 2.40E-01 5.88E-02 NaN "NAIP,Naip1 (includes others)" Phospholipases 2.40E-01 5.88E-02 NaN "PLCG2,PLD4" Xenobiotic Metabolism PXR Signaling Pathway 2.40E-01 4.46E-02 -0.447 "MAOB,PRKCB,PRKCH,UGT1A4,Ugt1a7c" Nur77 Signaling in T Lymphocytes 2.25E-01 5.71E-02 NaN "CD28,FCER1G" IL-17 Signaling 2.21E-01 4.84E-02 NaN "CCL2,MMP3,PIK3R6" CCR3 Signaling in Eosinophils 2.21E-01 4.49E-02 NaN "GNG2,PIK3R6,PRKCB,PRKCH" The Visual Cycle 2.21E-01 8.33E-02 NaN DHRS9 Sperm Motility 2.21E-01 4.17E-02 NaN "BTK,CSF1R,MERTK,PLCG2,PRKCB,PRKCH" p38 MAPK Signaling 2.21E-01 4.49E-02 2 "IL1A,IL1B,MAP3K5,TNF" Adrenomedullin signaling pathway 2.21E-01 4.17E-02 2.449 "GNA15,IL1A,IL1B,PIK3R6,PLCG2,TNF" Synaptic Long Term Potentiation 2.09E-01 4.40E-02 2 "GNA15,PLCG2,PRKCB,PRKCH" Paxillin Signaling 2.09E-01 4.40E-02 NaN "ITGAL,ITGAM,ITGB2,PIK3R6" FGF Signaling 2.09E-01 4.69E-02 NaN "MAP3K5,PIK3R6,PTPN6" Integrin Signaling 2.09E-01 4.00E-02 2.646 "CAPN3,ITGAL,ITGAM,ITGB2,PIK3R6,PLCG2,RAC2" IL-7 Signaling Pathway 2.09E-01 4.69E-02 NaN "IL2RG,IL7R,PIK3R6" Choline Biosynthesis III 2.08E-01 7.69E-02 NaN PLD4 Protein Kinase A Signaling 2.01E-01 3.75E-02 0.333 "ADD2,EBI3,GNG2,NFATC2,PLCG2,PRKCB,PRKCH,PTPN18,PTPN6,PTPRC,TNNI2" Role of Tissue Factor in Cancer 2.01E-01 4.30E-02 NaN "ARRB2,GNA15,IL1B,PIK3R6" Opioid Signaling Pathway 2.01E-01 3.93E-02 1.633 "ARRB2,CACNA1A,GNG2,PRKCB,PRKCH,RAC2,RGS1" Lipid Antigen Presentation by CD1 1.96E-01 7.14E-02 NaN FCER1G Oxidative Ethanol Degradation III 1.96E-01 7.14E-02 NaN ACSS1 Superpathway of Inositol Phosphate Compounds 1.90E-01 3.95E-02 1.633 "INPP5D,NUDT11,PIK3R6,PLCG2,PTPN6,PTPRC" Sertoli Cell-Sertoli Cell Junction Signaling 1.88E-01 4.03E-02 NaN "CLDN1,MAP3K5,MAP3K9,MYO7A,TNF" Corticotropin Releasing Hormone Signaling 1.87E-01 4.17E-02 1 "CACNA1A,PLCG2,PRKCB,PRKCH" Axonal Guidance Signaling 1.85E-01 3.63E-02 NaN "ADAM8,GNA15,GNG2,MMP3,NFATC2,PIK3R6,PLCG2,PLXNC1,PRKCB,PRKCH,RAC2,SEMA4D,WNT2B" Putrescine Degradation III 1.85E-01 6.67E-02 NaN MAOB FAT10 Signaling Pathway 1.85E-01 6.67E-02 NaN TNF Apelin Endothelial Signaling Pathway 1.80E-01 4.08E-02 2 "CCL2,PIK3R6,PRKCB,PRKCH" NRF2-mediated Oxidative Stress Response 1.79E-01 3.85E-02 NaN "DNAJC6,MAP3K5,PIK3R6,PRKCB,PRKCH,SOD3" Aldosterone Signaling in Epithelial Cells 1.79E-01 3.88E-02 2 "DNAJC6,PIK3R6,PLCG2,PRKCB,PRKCH" Dopamine Degradation 1.79E-01 6.25E-02 NaN MAOB "Tryptophan Degradation X (Mammalian, via Tryptamine)" 1.79E-01 6.25E-02 NaN MAOB 1D-myo-inositol Hexakisphosphate Biosynthesis II (Mammalian) 1.79E-01 6.25E-02 NaN INPP5D "D-myo-inositol (1,3,4)-trisphosphate Biosynthesis" 1.79E-01 6.25E-02 NaN INPP5D "D-myo-inositol (1,4,5)-trisphosphate Degradation" 1.79E-01 6.25E-02 NaN INPP5D Tryptophan Degradation III (Eukaryotic) 1.79E-01 6.25E-02 NaN HAAO GPCR-Mediated Integration of Enteroendocrine Signaling Exemplified by an L Cell 1.71E-01 4.55E-02 NaN "GNA15,PLCG2" "Role of JAK1, JAK2 and TYK2 in Interferon Signaling" 1.69E-01 5.88E-02 NaN PTPN6 Ethanol Degradation IV 1.69E-01 5.88E-02 NaN ACSS1 UVC-Induced MAPK Signaling 1.69E-01 4.44E-02 NaN "PRKCB,PRKCH" cAMP-mediated signaling 1.69E-01 3.79E-02 2.236 "ADORA3,AGTR1,CNR2,P2RY12,P2RY13" Endocannabinoid Developing Neuron Pathway 1.69E-01 3.92E-02 2 "CNR2,GNG2,PIK3R6,RAC2" Apelin Cardiac Fibroblast Signaling Pathway 1.69E-01 5.88E-02 NaN AGTR1 Factors Promoting Cardiogenesis in Vertebrates 1.63E-01 3.85E-02 2 "PLCG2,PRKCB,PRKCH,WNT2B" GABA Receptor Signaling 1.62E-01 4.35E-02 NaN "CACNA1A,GABRB3" NGF Signaling 1.61E-01 3.81E-02 2 "MAP3K5,MAP3K9,PIK3R6,PLCG2" Retinol Biosynthesis 1.61E-01 5.56E-02 NaN DHRS9 Autophagy 1.56E-01 4.26E-02 NaN "CTSE,CTSS" Neuregulin Signaling 1.55E-01 3.75E-02 NaN "PLCG2,PRKCB,PRKCH" Cytotoxic T Lymphocyte-mediated Apoptosis of Target Cells 1.55E-01 5.26E-02 NaN FCER1G CD27 Signaling in Lymphocytes 1.55E-01 4.08E-02 NaN "MAP3K5,MAP3K9" Semaphorin Signaling in Neurons 1.55E-01 4.00E-02 NaN "RAC2,SEMA4D" Melanocyte Development and Pigmentation Signaling 1.55E-01 3.75E-02 NaN "PIK3R6,PLCG2,PTPN6" FAK Signaling 1.55E-01 3.75E-02 NaN "CAPN3,PIK3R6,PLCG2" Tumoricidal Function of Hepatic Natural Killer Cells 1.55E-01 5.26E-02 NaN ITGAL IL-17A Signaling in Gastric Cells 1.55E-01 5.00E-02 NaN TNF Retinoate Biosynthesis I 1.55E-01 5.26E-02 NaN DHRS9 "D-myo-inositol (1,4,5)-Trisphosphate Biosynthesis" 1.55E-01 5.00E-02 NaN PLCG2 Glutathione-mediated Detoxification 1.55E-01 5.00E-02 NaN HPGDS Salvage Pathways of Pyrimidine Ribonucleotides 1.55E-01 3.85E-02 NaN "APOBEC1,MAP3K9,PRKCH" Wnt/Ca+ pathway 1.55E-01 4.17E-02 NaN "NFATC2,PLCG2" Endoplasmic Reticulum Stress Pathway 1.55E-01 5.00E-02 NaN MAP3K5 Dopamine Receptor Signaling 1.55E-01 4.00E-02 NaN "MAOB,PCBD1" Apelin Liver Signaling Pathway 1.55E-01 5.00E-02 NaN TNF IL-1 Signaling 1.51E-01 3.70E-02 NaN "GNA15,GNG2,IL1A" MIF-mediated Glucocorticoid Regulation 1.51E-01 4.76E-02 NaN CD14 Gap Junction Signaling 1.51E-01 3.50E-02 NaN "GJB6,PIK3R6,PLCG2,PRKCB,PRKCH" "Superpathway of D-myo-inositol (1,4,5)-trisphosphate Metabolism" 1.51E-01 4.76E-02 NaN INPP5D IL-2 Signaling 1.51E-01 3.92E-02 NaN "IL2RG,PIK3R6" ILK Signaling 1.41E-01 3.45E-02 2 "ITGB2,MYH1,PIK3R6,RAC2,TNF" IL-17A Signaling in Airway Cells 1.38E-01 3.77E-02 NaN "CXCL3,PIK3R6" PPARα/RXRα Activation 1.30E-01 3.38E-02 NaN "CD36,GNA15,IL1B,PLCG2,PRKCB" RhoA Signaling 1.30E-01 3.49E-02 NaN "ARHGAP4,ARHGAP9,LPAR5" D-myo-inositol-5-phosphate Metabolism 1.30E-01 3.42E-02 1 "NUDT11,PLCG2,PTPN6,PTPRC" 3-phosphoinositide Degradation 1.28E-01 3.39E-02 1 "INPP5D,NUDT11,PTPN6,PTPRC" PPAR Signaling 1.27E-01 3.45E-02 NaN "IL1A,IL1B,TNF" Role of p14/p19ARF in Tumor Suppression 1.26E-01 4.17E-02 NaN PIK3R6 Sonic Hedgehog Signaling 1.26E-01 4.17E-02 NaN ARRB2 IL-15 Production 1.19E-01 3.37E-02 NaN "BTK,CSF1R,MERTK" Role of JAK family kinases in IL-6-type Cytokine Signaling 1.17E-01 4.00E-02 NaN OSM Role of JAK2 in Hormone-like Cytokine Signaling 1.08E-01 3.85E-02 NaN PTPN6 Pyridoxal 5'-phosphate Salvage Pathway 1.08E-01 3.39E-02 NaN "MAP3K9,PRKCH" Glutamate Receptor Signaling 1.02E-01 3.70E-02 NaN GNG2 IL-15 Signaling 1.01E-01 3.28E-02 NaN "IL2RG,PIK3R6" Angiopoietin Signaling 1.01E-01 3.28E-02 NaN "DOK2,PIK3R6" MIF Regulation of Innate Immunity 9.75E-02 3.57E-02 NaN CD14 Inhibition of Angiogenesis by TSP1 9.75E-02 3.57E-02 NaN CD36 4-1BB Signaling in T Lymphocytes 9.10E-02 3.45E-02 NaN MAP3K5 IL-17A Signaling in Fibroblasts 9.10E-02 3.45E-02 NaN CCL2 Glucocorticoid Receptor Signaling 0.00E+00 3.06E-02 NaN "CCL2,FCGR1A,IL1B,NFATC2,PIK3R6,PLAU,TNF" Aryl Hydrocarbon Receptor Signaling 0.00E+00 2.61E-02 NaN "IL1A,IL1B,TNF" p53 Signaling 0.00E+00 1.27E-02 NaN PIK3R6 Ceramide Signaling 0.00E+00 2.74E-02 NaN "PIK3R6,TNF" PXR/RXR Activation 0.00E+00 2.86E-02 NaN TNF Tight Junction Signaling 0.00E+00 2.65E-02 NaN "CLDN1,MYH1,TNF" TR/RXR Activation 0.00E+00 1.69E-02 NaN PIK3R6 Regulation of Actin-based Motility by Rho 0.00E+00 1.43E-02 NaN RAC2 Activation of IRF by Cytosolic Pattern Recognition Receptors 0.00E+00 2.27E-02 NaN TNF CD40 Signaling 0.00E+00 1.75E-02 NaN PIK3R6 Lymphotoxin β Receptor Signaling 0.00E+00 2.13E-02 NaN PIK3R6 B Cell Activating Factor Signaling 0.00E+00 2.78E-02 NaN NFATC2 HIF1α Signaling 0.00E+00 2.50E-02 NaN "MMP3,PIK3R6" Relaxin Signaling 0.00E+00 2.70E-02 NaN "GNA15,GNG2,PIK3R6" CNTF Signaling 0.00E+00 2.00E-02 NaN PIK3R6 CDK5 Signaling 0.00E+00 1.15E-02 NaN CACNA1A FLT3 Signaling in Hematopoietic Progenitor Cells 0.00E+00 2.82E-02 NaN "INPP5D,PIK3R6" Human Embryonic Stem Cell Pluripotency 0.00E+00 2.08E-02 NaN "PIK3R6,WNT2B" Role of NANOG in Mammalian Embryonic Stem Cell Pluripotency 0.00E+00 2.30E-02 NaN "PIK3R6,WNT2B" mTOR Signaling 0.00E+00 2.89E-02 2 "PIK3R6,PLD4,PRKCB,PRKCH,RAC2" Myc Mediated Apoptosis Signaling 0.00E+00 2.27E-02 NaN TNF Cdc42 Signaling 0.00E+00 3.12E-02 NaN "FCER1G,H2-M1/H2-M9,VAV1" EIF2 Signaling 0.00E+00 1.16E-02 NaN "PIK3R6,Rpl39l" April Mediated Signaling 0.00E+00 2.78E-02 NaN NFATC2 Retinoic acid Mediated Apoptosis Signaling 0.00E+00 2.86E-02 NaN CRABP1 AMPK Signaling 0.00E+00 1.22E-02 NaN "PIK3R6,RAB39A" PAK Signaling 0.00E+00 2.56E-02 NaN "PIK3R6,TNF" Rac Signaling 0.00E+00 3.06E-02 NaN "CYBB,NCF1,PIK3R6" Regulation of eIF4 and p70S6K Signaling 0.00E+00 7.75E-03 NaN PIK3R6 Actin Nucleation by ARP-WASP Complex 0.00E+00 1.64E-02 NaN RAC2 Telomerase Signaling 0.00E+00 2.27E-02 NaN "IL2RG,PIK3R6" Mouse Embryonic Stem Cell Pluripotency 0.00E+00 1.14E-02 NaN PIK3R6 iNOS Signaling 0.00E+00 2.50E-02 NaN CD14 ErbB2-ErbB3 Signaling 0.00E+00 1.79E-02 NaN PIK3R6 "D-myo-inositol (1,4,5,6)-Tetrakisphosphate Biosynthesis" 0.00E+00 2.80E-02 NaN "NUDT11,PTPN6,PTPRC" "D-myo-inositol (3,4,5,6)-tetrakisphosphate Biosynthesis" 0.00E+00 2.80E-02 NaN "NUDT11,PTPN6,PTPRC" 3-phosphoinositide Biosynthesis 0.00E+00 3.12E-02 1 "NUDT11,PIK3R6,PTPN6,PTPRC" Stearate Biosynthesis I (Animals) 0.00E+00 2.86E-02 NaN TBXAS1 Epithelial Adherens Junction Signaling 0.00E+00 1.83E-02 NaN "MYH1,MYO7A" Gαs Signaling 0.00E+00 3.08E-02 NaN "ADD2,GNG2" PEDF Signaling 0.00E+00 1.37E-02 NaN PIK3R6 Regulation of Cellular Mechanics by Calpain Protease 0.00E+00 2.08E-02 NaN CAPN3 Regulation of the Epithelial-Mesenchymal Transition Pathway 0.00E+00 1.38E-02 NaN "PIK3R6,WNT2B" UVA-Induced MAPK Signaling 0.00E+00 2.30E-02 NaN "PIK3R6,PLCG2" Oxidative Phosphorylation 0.00E+00 1.28E-02 NaN COX6A2 Adipogenesis pathway 0.00E+00 9.09E-03 NaN TNF HIPPO signaling 0.00E+00 1.45E-02 NaN WWC1 PCP pathway 0.00E+00 2.27E-02 NaN WNT2B Unfolded protein response 0.00E+00 1.89E-02 NaN MAP3K5 Estrogen Receptor Signaling 0.00E+00 3.10E-02 2.828 "CACNA1A,GNA15,GNG2,MMP3,PIK3R6,PLCG2,PRKCB,PRKCH" EGF Signaling 0.00E+00 1.92E-02 NaN PIK3R6 ERK/MAPK Signaling 0.00E+00 2.63E-02 2 "PIK3R6,PLCG2,PRKCB,RAC2" PTEN Signaling 0.00E+00 2.61E-02 NaN "INPP5D,RAC2,TNFRSF11A" Cardiac β-adrenergic Signaling 0.00E+00 3.03E-02 NaN "ATP2A3,CACNA1A,GNG2" Protein Ubiquitination Pathway 0.00E+00 4.27E-03 NaN DNAJC6 JAK/Stat Signaling 0.00E+00 2.78E-02 NaN "PIK3R6,PTPN6" Wnt/β-catenin Signaling 0.00E+00 7.94E-03 NaN WNT2B Insulin Receptor Signaling 0.00E+00 1.74E-02 NaN "INPP5D,PIK3R6" Neurotrophin/TRK Signaling 0.00E+00 3.08E-02 NaN "MAP3K5,PIK3R6" IGF-1 Signaling 0.00E+00 2.17E-02 NaN "IGFBP3,PIK3R6" TGF-β Signaling 0.00E+00 1.32E-02 NaN RUNX3 Sumoylation Pathway 0.00E+00 2.17E-02 NaN "MAP3K5,RAC2" Sirtuin Signaling Pathway 0.00E+00 8.77E-03 NaN "SOD3,TNF" Iron homeostasis signaling pathway 0.00E+00 1.02E-02 NaN ATP6V1G2 Endocannabinoid Cancer Inhibition Pathway 0.00E+00 2.42E-02 NaN "CASP1,CNR2,PIK3R6" Apelin Pancreas Signaling Pathway 0.00E+00 2.70E-02 NaN PIK3R6 Apelin Adipocyte Signaling Pathway 0.00E+00 3.23E-02 NaN "CYBB,NCF1" FAT10 Cancer Signaling Pathway 0.00E+00 2.44E-02 NaN TNF PFKFB4 Signaling Pathway 0.00E+00 2.56E-02 NaN HK3 Synaptogenesis Signaling Pathway 0.00E+00 2.17E-02 1.342 "APOE,CDH13,CDH8,PIK3R6,PLCG2" Senescence Pathway 0.00E+00 2.63E-02 2.449 "CACNA1A,CAPN3,IL1A,NFATC2,PIK3R6,TLR2" White Adipose Tissue Browning Pathway 0.00E+00 2.33E-02 NaN "CACNA1A,FCER1G" Inhibition of ARE-Mediated mRNA Degradation Pathway 0.00E+00 1.15E-02 NaN TNF HOTAIR Regulatory Pathway 0.00E+00 2.83E-02 NaN "MMP3,PIK3R6,WNT2B" Ephrin Receptor Signaling 0.00E+00 2.03E-02 NaN "GNA15,GNG2,RAC2"