{"text_format":"3","workbook":"xls","n_sheets":8,"sheets":["blue","green","orangered4","plum1","plum2","salmon4","thistle2","violet"],"read":"whole","date_system":"1900","formulas":"cached_only"}

{"sheet":"blue","index":0,"n_rows":21,"n_cols":4,"rows_kept":21,"flags":["formulas_cached_only"]}
["biological process","cellular function","disease or syndrome ","molecular function"]
["Sumoylation","Centrosome","neu-laxova syndrome","ubiquitin activity"]
["Nuclear Export","endosomal sorting complex required for transport location","paroxysmal kinesigenic choreoathetosis","protein folding chaperone"]
["nucleocytoplasmic transport","anaphase-promoting complex","tuberous sclerosis 2 (disorder)","ubiquitin binding"]
["polyubiquitin activity","26s proteasome location","type i primary hyperoxaluria","proteasome endopeptidase complex"]
["Nuclear Import","ribonucleoprotein complex location","niemann-pick disease, type c","ikappab kinase activity"]
["histone modification","Spliceosomes","type 2 polycystic kidney disease","[hydroxymethylglutaryl-coa reductase (nadph)] kinase activity"]
["chromatin remodeling","chromatin location","muscular dystrophy, emery-dreifuss","camp-dependent protein kinase activity"]
["cell cycle checkpoint","nucleosome location","tuberous sclerosis 1 (disorder)","[acetyl-coa carboxylase] kinase activity"]
["Deubiquitination","Endosomes","Tauopathies","cyclin-dependent protein kinase regulator activity"]
["cyclin-dependent protein kinase inhibitor activity","ikappab kinase complex","hereditary gingival fibromatosis","RNA Binding"]
["tumor suppressor activity","ubiquitin ligase complex","Neurodegenerative Disorders","cyclin-dependent protein kinase inhibitor activity"]
["pre-mrna splicing","positive transcription elongation factor complex location b","niemann-pick diseases","kinase activity"]
["Histone Acetylation","Nuclear speck","Huntington Disease","26s protease activity"]
["Transcription Elongation","trans-golgi network","alzheimer disease, familial","ubiquitin-protein ligase activity"]
["vesicle-mediated transport","Intranuclear body","retinitis pigmentosa 2 (disorder)","1-phosphatidylinositol-3-kinase activity"]
["chromatin assembly and disassembly","chromatin remodeling complex location","hemophagocytic lymphohistiocytosis, familial, 2","map kinase kinase activity"]
["Autophagy","signalosome","Recruitment","map kinase kinase kinase activity"]
["cell cycle arrest","small nuclear ribonucleoprotein complex location","retinitis pigmentosa 3","cyclin-dependent protein kinase activity"]
["histone methylation","histone deacetylase complexes","Nasopharyngeal carcinoma","anaphase-promoting complex activity"]
["Protein Dephosphorylation","late endosome","peutz-jeghers syndrome","phosphatase 2A"]

{"sheet":"green","index":1,"n_rows":21,"n_cols":4,"rows_kept":21,"flags":["formulas_cached_only"]}
["biological process","cellular function","disease or syndrome ","molecular function"]
["Sumoylation","endosomal sorting complex required for transport location","neu-laxova syndrome","ubiquitin activity"]
["tumor suppressor activity","Centrosome","paroxysmal kinesigenic choreoathetosis","1-phosphatidylinositol-3-kinase activity"]
["cyclin-dependent protein kinase inhibitor activity","ubiquitin ligase complex","spastic paraplegia 4, autosomal dominant","cyclin-dependent protein kinase inhibitor activity"]
["Deubiquitination","Endosomes","tuberous sclerosis 2 (disorder)","protein folding chaperone"]
["polyubiquitin activity","anaphase-promoting complex","type i primary hyperoxaluria","proteasome endopeptidase complex"]
["nucleocytoplasmic transport","26s proteasome location","spastic paraplegia, hereditary","ubiquitin binding"]
["Nuclear Export","trans-golgi network","Troyer syndrome","ubiquitin-protein ligase activity"]
["cell cycle arrest","Golgi Apparatus","tuberous sclerosis 1 (disorder)","cyclin-dependent protein kinase regulator activity"]
["vesicle-mediated transport","Early endosome","muscular dystrophy, emery-dreifuss","kinase activity"]
["cell cycle checkpoint","chromatin location","spinocerebellar ataxia type 7","mp kinase activity"]
["protein ubiquitination","late endosome","Rieger syndrome","map kinase kinase activity"]
["cell cycle regulation","signalosome","hyperparathyroidism-jaw tumor syndrome","anaphase-promoting complex activity"]
["Nuclear Import","recycling endosome","Fanconi Anemia","ERK1 activity"]
["mitotic cell cycle","Intranuclear body","Centronuclear myopathy","map kinase kinase kinase activity"]
["Cell Cycle","Endoplasmic Reticulum","machado-joseph disease","map kinase activity"]
["histone modification","Kinetochores","hereditary autosomal dominant spastic paraplegia","p53 binding"]
["er-associated protein catabolic process","nucleosome location","Noonan Syndrome","epidermal growth factor receptor activity"]
["Cytokinesis","Golgi membrane","Progeria","cyclin-dependent protein kinase activity"]
["protein transport","pole of spindle","van der woude syndrome","pyruvate dehydrogenase (acetyl-transferring) kinase activity"]
["centrosome duplication","Microtubules","Ataxia, Spinocerebellar","ligase activity"]

{"sheet":"orangered4","index":2,"n_rows":21,"n_cols":4,"rows_kept":21,"flags":["formulas_cached_only"]}
["biological process","cellular function","disease or syndrome ","molecular function"]
["nitric-oxide synthase inhibitor activity","ampa receptor location","aromatic alpha-keto acid reductase","diiodophenylpyruvate reductase activity"]
["protein targeting to lysosome","post-synaptic density","Myxomatosis, Infectious","nos activity (molecular function)"]
["RNA Editing","ionotropic glutamate receptor complex","Huntington Disease","aldose reductase activity"]
["base excision repair","endosomal sorting complex required for transport location","hair morphology 1","nitric oxide synthase activity"]
["long-term potentiation","Presynaptic Terminals","epilepsy, lateral temporal","n-methyl-d-aspartate selective glutamate receptor activity"]
["regulation of synapse","calmodulin-dependent protein kinase activity","dominant intermediate c charcot-marie-tooth disease","nadph diaphorase activity"]
["NADPH oxidation","Synapses","epilepsy, lateral temporal lobe, autosomal dominant","endonuclease activity"]
["neuron death","Excitatory Synapse","photoparoxysmal response 1","ionotropic glutamate receptor activity"]
["Sumoylation","juxtaparanode region of axon","type i primary hyperoxaluria","mannose binding"]
["nitric oxide biosynthetic process","potassium channel complex","Diabetic cataract","membrane-associated guanylate kinase activity"]
["sorbitol biosynthetic process","Spliceosomes","Oculopalatoskeletal syndrome","calmodulin-dependent protein kinase activity"]
["mRNA editing","Nerve Endings","autosomal dominant partial epilepsy with auditory features","oxidoreductase activity"]
["pre-mrna splicing","Synaptic Vesicles","Diabetic Neuropathies","fibroblast growth factor binding"]
["Synaptic Transmission","Dendritic Spines","x-linked 1 spinal and bulbar muscular atrophy","glutamate binding"]
["inhibition of glutamate secretion","cell body","bilateral cataracts (disorder)","dynein activity"]
["regulation of membrane potential","Synaptosomes","Mucolipidoses","carbonyl reductase (nadph) activity"]
["glutamatergic synaptic transmission","cell body of neuron","Episodic ataxia","diaphorase activity"]
["protein desumoylation","Autophagic vacuoles","spinocerebellar ataxia 17","nitric-oxide synthase binding"]
["tubuloglomerular feedback","Postsynaptic Membrane","Nodular glomerulosclerosis","ubiquitin activity"]
["regulation of cellular respiration","Dendrites","Diabetic Nephropathy","glycosylase"]

{"sheet":"plum1","index":3,"n_rows":21,"n_cols":4,"rows_kept":21,"flags":["formulas_cached_only"]}
["biological process","cellular function","disease or syndrome ","molecular function"]
["meiotic recombination checkpoint","Caveolae","spinocerebellar ataxia 12","nad(p)h dehydrogenase (quinone) activity"]
["caveola assembly","caveolar membrane","spinocerebellar ataxia 8","hormone-sensitive lipase activity"]
["Fibrinolysis","membrane raft","spinocerebellar ataxia type 2","3-OST-2"]
["plasminogen activation","trans-golgi network","Bloom Syndrome","dihydronicotinamide riboside quinone reductase activity"]
["cholesterol efflux","glycolipid-enriched membrane domain","spinocerebellar ataxia type 6 (disorder)","3-OST-3"]
["Protein Prenylation","Golgi Apparatus","spinocerebellar ataxia type 7","u-plasminogen activator receptor activity"]
["Cholesterol Homeostasis","eisosome","machado-joseph disease","nucleosome binding"]
["Endocytosis","mitotic checkpoint complex location","spinocerebellar ataxia type 1","dt-diaphorase activity"]
["cholesterol biosynthetic process","Focal Adhesions","spinocerebellar ataxia 10","cholesterol esterase activity"]
["pachytene","Endosomes","Werner Syndrome","protein kinase c binding"]
["Meiosis","Synaptonemal Complex","spinocerebellar ataxia 17","cholesterol binding"]
["Anaphase","Golgi ribbon","Ataxia, Spinocerebellar","GTP Binding"]
["Mitotic Anaphase","SMN Complex","cholesterol ester storage disease","sulfotransferase activity"]
["Meiotic Recombination","late endosome","type 2 (disorder) pachyonychia congenita","helicase activity"]
["Mitotic Prophase","Kinetochores","jadassohn lewandowsky type pachyonychia congenita","ERK1 activity"]
["protein transport","Golgi membrane","spinocerebellar ataxia 14","[hydroxymethylglutaryl-coa reductase (nadph)] kinase activity"]
["cell cycle checkpoint","Early endosome","Wolman Disease","camp-dependent protein kinase activity"]
["activation of protein complex assembly","recycling endosome","Diastrophic dysplasia","[acetyl-coa carboxylase] kinase activity"]
["tumor suppressor activity","camp-dependent protein kinase complex location","spinocerebellar degeneration","cholesteryl ester hydrolase activity"]
["Lipolysis","Meiotic chromosome","Hypogonadotropic hypogonadism","geranyltransferase activity"]

{"sheet":"plum2","index":4,"n_rows":21,"n_cols":4,"rows_kept":21,"flags":["formulas_cached_only"]}
["biological process","cellular function","disease or syndrome ","molecular function"]
["m phase of mitotic cell cycle","endosomal sorting complex required for transport location","human herpes virus 8 infection","sialic acid binding"]
["negative regulation of wnt receptor signaling pathway","septin cytoskeleton","Troyer syndrome","ubiquitin-activating enzyme activity"]
["retinal pigment epithelium development","septin complex","kaposi sarcoma-associated herpesvirus infection","semicarbazide-sensitive amine oxidase activity"]
["Chromatin Modeling","trap complex location","Idiopathic polyarthritis","insulin-like growth factor binding"]
["bmp signaling pathway","b-cell receptor complex location","Angiolymphoid hyperplasia","ubiquitin activity"]
["chorio-allantoic fusion","pre-b cell receptor complex","Herpesviridae Infections","ligase activity"]
["regulation of photomorphogenesis","histone acetyltransferase complex","late spondyloepiphyseal dysplasia","enzyme activator activity"]
["rotokinesis","Mitotic chromosome","Mucopolysaccharidosis IV","beta-catenin binding"]
["dorsal-ventral pattern formation","Autosome","Norrie disease","transmembrane receptor activity"]
["neutrophil mediated immunity","capsomere","Trisomy 12","anaphase-promoting complex activity"]
["histone ubiquitination","anaphase-promoting complex","neu-laxova syndrome","ubiquitin-protein ligase activity"]
["plant development in response to light","nurd complex location","macular corneal dystrophy type i","ubiquitin binding"]
["photomorphogenesis","elg1 rfc-like complex","Werner Syndrome","CTPase activity"]
["Sumoylation","26s proteasome location","renal tubular acidosis","proteasome endopeptidase complex"]
["up regulation of transcription","septin ring","Spondyloepiphyseal Dysplasia","isg15 activating enzyme activity"]
["histone chaperone","cohesin complex","Neurogenic arthropathy","ubiquitin thioesterase activity"]
["protein ubiquitination","ikappab kinase complex","complete trisomy 18 syndrome","histone binding"]
["hemopoietic stem cell differentiation","integral to plasma membrane","autosomal dominant (disorder) craniodiaphyseal dysplasia","ubiquitin protein ligase binding"]
["stimulation of protein kinase activity","ubiquitin ligase complex","cafe au lait spots, multiple","vetispiradiene synthase activity"]
["mitotic sister chromatid segregation","Centromere","CAMPOMELIC DYSPLASIA","histone methyltransferase activity"]

{"sheet":"salmon4","index":5,"n_rows":21,"n_cols":4,"rows_kept":21,"flags":["formulas_cached_only"]}
["biological process","cellular function","disease or syndrome ","molecular function"]
["snRNP recycling","u5 snrnp location","progressive familial intrahepatic 3 cholestasis","p-glycoprotein activity"]
["engulfment of apoptotic cell","u4 snrnp location","progressive intrahepatic cholestasis (disorder)","retinol dehydrogenase activity"]
["via transesterification reactions rna splicing","catalytic step 1 spliceosome","progressive familial intrahepatic 2 cholestasis","atp-binding cassette (abc) transporter activity"]
["actin filament-based process","atp-binding cassette (abc) transporter activity","infection by human herpesvirus 7","multidrug resistance exporter"]
["flippase","u6 snrnp location","benign recurrent intrahepatic cholestasis","sialic acid binding"]
["rac protein signal transduction","Spliceosomes","Roseolovirus Infections","MDR protein"]
["spliceosome assembly pathway","small nuclear ribonucleoprotein complex location","Exanthema Subitum","ATP binding"]
["pre-mrna splicing","u1 snrnp location","cataract, autosomal recessive, early-onset, pulverulent","multidrug transporter activity"]
["Drug Transport","prespliceosome","Intrahepatic Cholestasis","2-ketobutyrate formate-lyase activity"]
["lens development in camera-type eye","u2 snrnp location","cholestasis, benign recurrent intrahepatic 2","snRNA binding"]
["bile salt transport","ruffle membrane","bilateral cataracts (disorder)","phosphatidylethanolamine n-methyltransferase activity"]
["phospholipid transport","Lamellipodia","congenital lamellar cataract","flippase activity"]
["spliceosome disassembly","nineteen complex","retinitis pigmentosa 13","GTP Binding"]
["small gtpase mediated signal transduction","commitment complex","Cholestasis","snRNP binding"]
["gonad morphogenesis","ribonucleoprotein complex location","jaundice, chronic idiopathic","rho guanine nucleotide exchange factor activity"]
["phospholipid translocation","Focal Adhesions","autosomal dominant cataract","primary active transporter"]
["myofiber development","snrnp u11 location","Lens Opacities","guanyl-nucleotide exchange factor activity"]
["activation of rac gtpase activity","cell surface extensions","infection by human herpesvirus 6","nucleotide binding"]
["phagosome formation","Pseudopodia","pulverulent Cataracts","adenosinetriphosphatase activity"]
["phospholipid dephosphorylation","phagocytic cup","cholestatic liver disease","tubulin gtpase activity"]

{"sheet":"thistle2","index":6,"n_rows":21,"n_cols":4,"rows_kept":21,"flags":["formulas_cached_only"]}
["biological process","cellular function","disease or syndrome ","molecular function"]
["sphingolipid biosynthetic process","leading edge membrane","type 1 hereditary sensory autonomic neuropathy","serine palmitoyltransferase activity"]
["protein localization at cell surface","actin cap","sensory neuropathy, hereditary","serine c-palmitoyltransferase activity"]
["sphingosine biosynthetic process","Actin myofilament","hereditary sensory and autonomic neuropathies","serine-pyruvate transaminase activity"]
["regulation of actin filament length","chloroplast chromosome","alpha-Dystroglycanopathies","protein o-mannosyltransferase activity"]
["sphingolipid metabolic process","Rpd3L complex","amyotrophic lateral sclerosis 5","enolase activity"]
["barbed-end actin filament capping","filamentous actin location","muscular dystrophy, limb-girdle, type 2k","3-ketosphinganine reductase activity"]
["inhibition of transcription factor activity","Stress Fibers","hemophagocytic lymphohistiocytosis, familial, 2","protein kinase activator activity"]
["ceramide biosynthetic process","H zone","wieacker-wolff syndrome","protein phosphatase binding"]
["SAPK cascade","Actin cytoskeleton","hereditary sensory radicular neuropathy","tropomyosin binding"]
["sphingomyelin biosynthetic process","dynactin complex","charcot-marie-tooth disease, axonal, type 2b (disorder)","tau kinase activity"]
["regulation of pharyngeal pumping","Adherens Junction","muscular dystrophy, limb-girdle, type 1b (disorder)","nervous system specific enolase activity"]
["actin filament severing","Zonula Adherens","type 2 hereditary sensory autonomic neuropathy","protein kinase binding"]
["negative regulation of cell cycle","intine","congenital muscular dystrophy (disorder)","reticuline oxidase activity"]
["regulation of cytoskeleton organization","costamere location","Posttransfusion purpura","alanine trna activity"]
["microtubule catastrophe","Focal Adhesions","type 1-like syndrome neurofibromatosis","sphingomyelin synthase activity"]
["myofibril assembly","Microfilaments","oral allergy syndrome","[phosphotyrosine]protein phosphatase activity"]
["plant development in response to light","M line","chronic skin ulcer","actin monomer binding"]
["ceramide metabolic process","Microtubule cytoskeleton","specific language impairment 2","actin binding"]
["focal adhesion assembly","Myosin myofilament","allergy to eggs","ceramide synthase activity"]
["tRNA methylation","Sarcomeres","muscle eye brain disease","protein tyrosine phosphatase activity"]

{"sheet":"violet","index":7,"n_rows":21,"n_cols":4,"rows_kept":21,"flags":["formulas_cached_only"]}
["biological process","cellular function","disease or syndrome ","molecular function"]
["transcription-coupled nucleotide-excision repair","cytolytic granule","lymphocytic choriomeningitis","interleukin-15 binding activity"]
["Lymphocyte Activation","Immunological Synapses","bilateral frontoparietal polymicrogyria","interleukin-12 binding activity"]
["cell activation","interleukin-23 complex","Rieger syndrome","interleukin-7 binding activity"]
["t-cell activation","interleukin-12 complex","pelger-huet anomaly","interferon-gamma binding"]
["Antigen Presentation","receptor complex","cardiomyopathy, dilated, 1b","interleukin-21 binding activity"]
["major histocompatibility complex location","membrane raft","simian acquired immunodeficiency syndrome","interleukin-5 binding activity"]
["antibody -dependent cell cytotoxicity","post-synaptic density","Tumor Immunity","interleukin-4 binding activity"]
["Cell development","interleukin-35 complex","congenital generalized lipodystrophy type 1","interleukin-2 receptor activity"]
["cytokine production","ampa receptor location","manifestations of immunopathology","interleukin-15 receptor activity"]
["t cell differentiation","Cell surface","lymphopenia","interleukin-18 binding activity"]
["killer activity","Focal Adhesions","graft-vs-host disease","interleukin-13 binding activity"]
["cytokine secretion","Viral envelope","Lymphohistiocytosis, Hemophagocytic","il-17 activity"]
["t-cell proliferation","t-cell receptor complex location","radiation chimera disorder","Betaglycan activity"]
["adaptive immune response","provirus location","dentatorubral-pallidoluysian atrophy","interleukin-10 binding activity"]
["cell recognition","integral to membrane","Listeriosis","interleukin-23 binding activity"]
["Immunity, Cellular","fully spanning the plasma membrane","Diabetes, Autoimmune","interleukin-7 receptor activity"]
["RANTES production","Endosomes","epstein-barr virus infections","granulocyte-macrophage colony stimulating factor activity"]
["Chemotaxis, Leukocyte","Intermediate Filaments","Allergic asthma","interleukin-8 receptor binding activity"]
["Cross-Priming","death-inducing signaling complex location","lymphoproliferative syndrome, x-linked, 1","epidermal growth factor receptor activity"]
["pathologic cytolysis","juxtamembrane","Arenaviridae Infections","interleukin-21 receptor activity"]