{"text_format":"3","workbook":"xls","n_sheets":2,"sheets":["S5 Dataset Sheet 1","S5 Dataset Sheet 2"],"read":"whole","date_system":"1900","formulas":"cached_only"}

{"sheet":"S5 Dataset Sheet 1","index":0,"n_rows":80,"n_cols":4,"rows_kept":80,"merged":[[1,0,1,3],[2,0,2,3],[5,0,5,3]],"flags":["formulas_cached_only"]}
[]
["Enrichment of extracellular vesicles from tissues of the central nervous system by PROSPR"]
["Xavier Gallart-Palau, Aida Serra and Siu Kwan Sze"]
[]
[]
["Supplementary Dataset 5.  List of 72 novel identified EV proteins from CNS tissue present in whole brain proteome."]
[]
["Accession","GS","Name","Protein Mass (Da)"]
["P17600","SYN1","SYN1_HUMAN Synapsin-1 OS=Homo sapiens GN=SYN1 PE=1 SV=3",74237]
["Q8N111","CEND1","CEND_HUMAN Cell cycle exit and neuronal differentiation protein 1 OS=Homo sapiens GN=CEND1 PE=2 SV=1",15002]
["Q9UQM7","CAMK2A","KCC2A_HUMAN Calcium/calmodulin-dependent protein kinase type II subunit alpha OS=Homo sapiens GN=CAMK2A PE=1 SV=2",54624]
["P01620","P01620","KV302_HUMAN Ig kappa chain V-III region SIE OS=Homo sapiens PE=1 SV=1",11882]
["P04271","S100B","S100B_HUMAN Protein S100-B OS=Homo sapiens GN=S100B PE=1 SV=2",10820]
["P43004","SLC1A2","EAA2_HUMAN Excitatory amino acid transporter 2 OS=Homo sapiens GN=SLC1A2 PE=1 SV=2",62577]
["C9JTE0","MOG","C9JTE0_HUMAN Myelin-oligodendrocyte glycoprotein OS=Homo sapiens GN=MOG PE=1 SV=1",24196]
["Q13554","CAMK2B","KCC2B_HUMAN Calcium/calmodulin-dependent protein kinase type II subunit beta OS=Homo sapiens GN=CAMK2B PE=1 SV=3",73544]
["Q92752","TNR","TENR_HUMAN Tenascin-R OS=Homo sapiens GN=TNR PE=1 SV=3",151805]
["A0A087WWB6","TAGLN3","A0A087WWB6_HUMAN Transgelin OS=Homo sapiens GN=TAGLN3 PE=1 SV=1",25223]
["P00403","MT-CO2","COX2_HUMAN Cytochrome c oxidase subunit 2 OS=Homo sapiens GN=MT-CO2 PE=1 SV=1",25719]
["Q5T7Y6","S100A1","Q5T7Y6_HUMAN Protein S100 OS=Homo sapiens GN=S100A1 PE=1 SV=1",16056]
["Q58FF6","HSP90AB4P","H90B4_HUMAN Putative heat shock protein HSP 90-beta 4 OS=Homo sapiens GN=HSP90AB4P PE=5 SV=1",58855]
["V9PBN7","AQP4","V9PBN7_HUMAN Aquaporin 4 isoform delta4 OS=Homo sapiens GN=AQP4 PE=1 SV=1",32262]
["Q7L0J3","SV2A","SV2A_HUMAN Synaptic vesicle glycoprotein 2A OS=Homo sapiens GN=SV2A PE=1 SV=1",83440]
["P14415","ATP1B2","AT1B2_HUMAN Sodium/potassium-transporting ATPase subunit beta-2 OS=Homo sapiens GN=ATP1B2 PE=1 SV=3",33745]
["Q9BY11","PACSIN1","PACN1_HUMAN Protein kinase C and casein kinase substrate in neurons protein 1 OS=Homo sapiens GN=PACSIN1 PE=1 SV=1",51276]
["P01616","P01616","KV203_HUMAN Ig kappa chain V-II region MIL OS=Homo sapiens PE=1 SV=1",12162]
["Q14CZ8","HEPACAM","HECAM_HUMAN Hepatocyte cell adhesion molecule OS=Homo sapiens GN=HEPACAM PE=1 SV=1",46226]
["P49418","AMPH","AMPH_HUMAN Amphiphysin OS=Homo sapiens GN=AMPH PE=1 SV=1",76381]
["Q5T3J1","HAPLN2","Q5T3J1_HUMAN Hyaluronan and proteoglycan link protein 2 (Fragment) OS=Homo sapiens GN=HAPLN2 PE=1 SV=1",21043]
["D3YTA9","PPP3R1","D3YTA9_HUMAN Calcineurin subunit B type 1 OS=Homo sapiens GN=PPP3R1 PE=1 SV=1",21717]
["A0A087WZQ7","NAPB","A0A087WZQ7_HUMAN Beta-soluble NSF attachment protein OS=Homo sapiens GN=NAPB PE=1 SV=1",34238]
["P01765","P01765","HV304_HUMAN Ig heavy chain V-III region TIL OS=Homo sapiens PE=1 SV=1",12462]
["A0A087X2B3","NRCAM","A0A087X2B3_HUMAN Neuronal cell adhesion molecule OS=Homo sapiens GN=NRCAM PE=1 SV=1",86036]
["Q6PUV4","CPLX2","CPLX2_HUMAN Complexin-2 OS=Homo sapiens GN=CPLX2 PE=2 SV=2",15499]
["P20916","MAG","MAG_HUMAN Myelin-associated glycoprotein OS=Homo sapiens GN=MAG PE=1 SV=1",69880]
["Q9P2U7","SLC17A7","VGLU1_HUMAN Vesicular glutamate transporter 1 OS=Homo sapiens GN=SLC17A7 PE=2 SV=1",62258]
["A0A087WYM3","SIRT2","A0A087WYM3_HUMAN NAD-dependent protein deacetylase sirtuin-2 OS=Homo sapiens GN=SIRT2 PE=1 SV=1",43958]
["Q9BPU6","DPYSL5","DPYL5_HUMAN Dihydropyrimidinase-related protein 5 OS=Homo sapiens GN=DPYSL5 PE=1 SV=1",61952]
["P02689","PMP2","MYP2_HUMAN Myelin P2 protein OS=Homo sapiens GN=PMP2 PE=1 SV=3",15014]
["O43761","SYNGR3","SNG3_HUMAN Synaptogyrin-3 OS=Homo sapiens GN=SYNGR3 PE=1 SV=2",24768]
["O43678","NDUFA2","NDUA2_HUMAN NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 OS=Homo sapiens GN=NDUFA2 PE=1 SV=3",11029]
["P23515","OMG","OMGP_HUMAN Oligodendrocyte-myelin glycoprotein OS=Homo sapiens GN=OMG PE=1 SV=2",50032]
["Q7L099","RUFY3","RUFY3_HUMAN Protein RUFY3 OS=Homo sapiens GN=RUFY3 PE=1 SV=1",53216]
["P78352","DLG4","DLG4_HUMAN Disks large homolog 4 OS=Homo sapiens GN=DLG4 PE=1 SV=3",80788]
["Q9H0Q3","FXYD6","FXYD6_HUMAN FXYD domain-containing ion transport regulator 6 OS=Homo sapiens GN=FXYD6 PE=1 SV=1",10706]
["P01762","P01762","HV301_HUMAN Ig heavy chain V-III region TRO OS=Homo sapiens PE=1 SV=1",13578]
["Q9UM19","HPCAL4","HPCL4_HUMAN Hippocalcin-like protein 4 OS=Homo sapiens GN=HPCAL4 PE=1 SV=3",22359]
["H0Y4J2","MRPL37","H0Y4J2_HUMAN 39S ribosomal protein L37, mitochondrial (Fragment) OS=Homo sapiens GN=MRPL37 PE=1 SV=1",29806]
["P00846","MT-ATP6","ATP6_HUMAN ATP synthase subunit a OS=Homo sapiens GN=MT-ATP6 PE=1 SV=1",24801]
["P30531","SLC6A1","SC6A1_HUMAN Sodium- and chloride-dependent GABA transporter 1 OS=Homo sapiens GN=SLC6A1 PE=1 SV=2",67827]
["A0A0C4DG09","CADM3","A0A0C4DG09_HUMAN Cell adhesion molecule 3 (Fragment) OS=Homo sapiens GN=CADM3 PE=1 SV=1",25981]
["A0A0A0MTP9","FAIM2","A0A0A0MTP9_HUMAN Protein lifeguard 2 (Fragment) OS=Homo sapiens GN=FAIM2 PE=1 SV=1",27606]
["P01621","P01621","KV303_HUMAN Ig kappa chain V-III region NG9 (Fragment) OS=Homo sapiens PE=2 SV=1",10836]
["P23471","PTPRZ1","PTPRZ_HUMAN Receptor-type tyrosine-protein phosphatase zeta OS=Homo sapiens GN=PTPRZ1 PE=1 SV=4",255683]
["Q8TB36","GDAP1","GDAP1_HUMAN Ganglioside-induced differentiation-associated protein 1 OS=Homo sapiens GN=GDAP1 PE=1 SV=3",41548]
["P0C7P4","UQCRFS1P1","UCRIL_HUMAN Putative cytochrome b-c1 complex subunit Rieske-like protein 1 OS=Homo sapiens GN=UQCRFS1P1 PE=5 SV=1",31081]
["P01742","P01742","HV101_HUMAN Ig heavy chain V-I region EU OS=Homo sapiens PE=1 SV=1",12578]
["S4R435","RPS10-NUDT3","S4R435_HUMAN Protein RPS10-NUDT3 (Fragment) OS=Homo sapiens GN=RPS10-NUDT3 PE=3 SV=1",32633]
["P78357","CNTNAP1","CNTP1_HUMAN Contactin-associated protein 1 OS=Homo sapiens GN=CNTNAP1 PE=1 SV=1",158220]
["H7C4W3","SYP","H7C4W3_HUMAN Synaptophysin (Fragment) OS=Homo sapiens GN=SYP PE=1 SV=1",21639]
["A0A0C4DGS0","NDUFA6","A0A0C4DGS0_HUMAN NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 OS=Homo sapiens GN=NDUFA6 PE=1 SV=1",15127]
["Q8N3J6","CADM2","CADM2_HUMAN Cell adhesion molecule 2 OS=Homo sapiens GN=CADM2 PE=2 SV=1",47980]
["A0A0A0MSG0","WIPF3","A0A0A0MSG0_HUMAN WAS/WASL-interacting protein family member 3 OS=Homo sapiens GN=WIPF3 PE=1 SV=1",49603]
["E5RHC5","ARFGAP1","E5RHC5_HUMAN ADP-ribosylation factor GTPase-activating protein 1 (Fragment) OS=Homo sapiens GN=ARFGAP1 PE=1 SV=2",29395]
["F6X2W2","NEGR1","F6X2W2_HUMAN Neuronal growth regulator 1 OS=Homo sapiens GN=NEGR1 PE=1 SV=1",33286]
["RRRQ9UQ90","SPG7","SPG7_HUMAN Paraplegin OS=Homo sapiens GN=SPG7 PE=1 SV=2",88407]
["P01717","P01717","LV403_HUMAN Ig lambda chain V-IV region Hil OS=Homo sapiens PE=1 SV=1",11624]
["Q6P587","FAHD1","FAHD1_HUMAN Acylpyruvase FAHD1, mitochondrial OS=Homo sapiens GN=FAHD1 PE=1 SV=2",25112]
["A0A087WYL5","SEZ6L2","A0A087WYL5_HUMAN Seizure 6-like protein 2 OS=Homo sapiens GN=SEZ6L2 PE=1 SV=1",100611]
["M0QZ28","DTNA","M0QZ28_HUMAN Dystrobrevin alpha OS=Homo sapiens GN=DTNA PE=1 SV=1",40918]
["H9KV31","NCAM2","H9KV31_HUMAN Neural cell adhesion molecule 2 OS=Homo sapiens GN=NCAM2 PE=1 SV=2",91864]
["H0YD97","PDHX","H0YD97_HUMAN Pyruvate dehydrogenase protein X component, mitochondrial (Fragment) OS=Homo sapiens GN=PDHX PE=1 SV=1",20718]
["Q99250","SCN2A","SCN2A_HUMAN Sodium channel protein type 2 subunit alpha OS=Homo sapiens GN=SCN2A PE=1 SV=3",229994]
["A0A0J9YWW6","APOO","A0A0J9YWW6_HUMAN MICOS complex subunit MIC26 (Fragment) OS=Homo sapiens GN=APOO PE=1 SV=1",9981]
["A0A0J9YX34","TRIM2","A0A0J9YX34_HUMAN Tripartite motif-containing protein 2 OS=Homo sapiens GN=TRIM2 PE=1 SV=1",59330]
["Q9UPA5","BSN","BSN_HUMAN Protein bassoon OS=Homo sapiens GN=BSN PE=2 SV=4",418324]
["Q5TF21","SOGA3","SOGA3_HUMAN Protein SOGA3 OS=Homo sapiens GN=SOGA3 PE=3 SV=1",103478]
["F8VP47","RPH3A","F8VP47_HUMAN Rabphilin-3A OS=Homo sapiens GN=RPH3A PE=1 SV=1",71955]
["A6NMB1","SIGLEC16","SIG16_HUMAN Sialic acid-binding Ig-like lectin 16 OS=Homo sapiens GN=SIGLEC16 PE=2 SV=3",53757]
["C9JXI5","TMEM198","C9JXI5_HUMAN Transmembrane protein 198 (Fragment) OS=Homo sapiens GN=TMEM198 PE=1 SV=1",24883]

{"sheet":"S5 Dataset Sheet 2","index":1,"n_rows":62,"n_cols":4,"rows_kept":62,"merged":[[1,0,1,3],[2,0,2,3],[5,0,5,3]],"flags":["formulas_cached_only"]}
[]
["Enrichment of extracellular vesicles from tissues of the central nervous system by PROSPR"]
["Xavier Gallart-Palau, Aida Serra and Siu Kwan Sze"]
[]
[]
["Supplementary Dataset 5.  List of 54 novel identified EV proteins from CNS tissue only present in EV-enriched fractions."]
[]
["Accession","GS","Name","Protein Mass (Da)"]
["Q9ULD0","OGDHL","OGDHL_HUMAN 2-oxoglutarate dehydrogenase-like, mitochondrial OS=Homo sapiens GN=OGDHL PE=1 SV=3",115264]
["P21397","MAOA","AOFA_HUMAN Amine oxidase [flavin-containing] A OS=Homo sapiens GN=MAOA PE=1 SV=1",60157]
["Q5F2F8","PPP3CB","Q5F2F8_HUMAN Serine/threonine-protein phosphatase OS=Homo sapiens GN=PPP3CB PE=1 SV=1",56720]
["Q8N9I0","SYT2","SYT2_HUMAN Synaptotagmin-2 OS=Homo sapiens GN=SYT2 PE=1 SV=2",47355]
["Q9UHC6","CNTNAP2","CNTP2_HUMAN Contactin-associated protein-like 2 OS=Homo sapiens GN=CNTNAP2 PE=1 SV=1",150183]
["Q13367","AP3B2","AP3B2_HUMAN AP-3 complex subunit beta-2 OS=Homo sapiens GN=AP3B2 PE=1 SV=2",119612]
["O75061","DNAJC6","AUXI_HUMAN Putative tyrosine-protein phosphatase auxilin OS=Homo sapiens GN=DNAJC6 PE=1 SV=3",100675]
["Q2TB90","HKDC1","HKDC1_HUMAN Putative hexokinase HKDC1 OS=Homo sapiens GN=HKDC1 PE=1 SV=3",103790]
["P43155","CRAT","CACP_HUMAN Carnitine O-acetyltransferase OS=Homo sapiens GN=CRAT PE=1 SV=5",71268]
["Q05329","GAD2","DCE2_HUMAN Glutamate decarboxylase 2 OS=Homo sapiens GN=GAD2 PE=1 SV=1",66224]
["E5RJ52","AP3M2","E5RJ52_HUMAN AP-3 complex subunit mu-2 (Fragment) OS=Homo sapiens GN=AP3M2 PE=1 SV=1",31866]
["A0A087X165","SRCIN1","A0A087X165_HUMAN SRC kinase-signaling inhibitor 1 OS=Homo sapiens GN=SRCIN1 PE=1 SV=1",130668]
["P33402","GUCY1A2","GCYA2_HUMAN Guanylate cyclase soluble subunit alpha-2 OS=Homo sapiens GN=GUCY1A2 PE=2 SV=1",82895]
["Q9BQ69","MACROD1","MACD1_HUMAN O-acetyl-ADP-ribose deacetylase MACROD1 OS=Homo sapiens GN=MACROD1 PE=1 SV=2",35996]
["Q5TH69","ARFGEF3","BIG3_HUMAN Brefeldin A-inhibited guanine nucleotide-exchange protein 3 OS=Homo sapiens GN=ARFGEF3 PE=1 SV=3",243862]
["Q96FC7","PHYHIPL","PHIPL_HUMAN Phytanoyl-CoA hydroxylase-interacting protein-like OS=Homo sapiens GN=PHYHIPL PE=1 SV=3",43029]
["Q9P121","NTM","NTRI_HUMAN Neurotrimin OS=Homo sapiens GN=NTM PE=1 SV=1",38518]
["Q9H1Z4","WDR13","WDR13_HUMAN WD repeat-containing protein 13 OS=Homo sapiens GN=WDR13 PE=1 SV=2",54289]
["E9PEF1","PDE2A","E9PEF1_HUMAN cGMP-dependent 3~,5~-cyclic phosphodiesterase OS=Homo sapiens GN=PDE2A PE=1 SV=2",95160]
["O75899","GABBR2","GABR2_HUMAN Gamma-aminobutyric acid type B receptor subunit 2 OS=Homo sapiens GN=GABBR2 PE=1 SV=1",106780]
["A0A0R4J2G7","NRXN1","A0A0R4J2G7_HUMAN Neurexin-1-beta OS=Homo sapiens GN=NRXN1 PE=1 SV=1",166431]
["C9JB30","MAPRE3","C9JB30_HUMAN Microtubule-associated protein RP/EB family member 3 (Fragment) OS=Homo sapiens GN=MAPRE3 PE=1 SV=1",24795]
["O14531","DPYSL4","DPYL4_HUMAN Dihydropyrimidinase-related protein 4 OS=Homo sapiens GN=DPYSL4 PE=1 SV=2",62466]
["D6RAG3","CPLX1","D6RAG3_HUMAN Complexin-1 (Fragment) OS=Homo sapiens GN=CPLX1 PE=1 SV=1",12460]
["Q12756","KIF1A","KIF1A_HUMAN Kinesin-like protein KIF1A OS=Homo sapiens GN=KIF1A PE=1 SV=2",192541]
["K7ELX4","FECH","K7ELX4_HUMAN Ferrochelatase, mitochondrial (Fragment) OS=Homo sapiens GN=FECH PE=1 SV=1",37215]
["P63215","GNG3","GBG3_HUMAN Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 OS=Homo sapiens GN=GNG3 PE=3 SV=1",8527]
["K7EKU3","FXYD7","K7EKU3_HUMAN FXYD domain-containing ion transport regulator 7 OS=Homo sapiens GN=FXYD7 PE=1 SV=1",13095]
["O14523","C2CD2L","C2C2L_HUMAN C2 domain-containing protein 2-like OS=Homo sapiens GN=C2CD2L PE=1 SV=3",76590]
["Q9UQ03","CORO2B","COR2B_HUMAN Coronin-2B OS=Homo sapiens GN=CORO2B PE=1 SV=4",55488]
["E7EWD3","ADAM23","E7EWD3_HUMAN Disintegrin and metalloproteinase domain-containing protein 23 OS=Homo sapiens GN=ADAM23 PE=1 SV=2",94553]
["O75438","NDUFB1","NDUB1_HUMAN NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 OS=Homo sapiens GN=NDUFB1 PE=1 SV=1",7014]
["Q86SK9","SCD5","SCD5_HUMAN Stearoyl-CoA desaturase 5 OS=Homo sapiens GN=SCD5 PE=1 SV=2",37814]
["D6R9Z7","COX7C","D6R9Z7_HUMAN Cytochrome c oxidase subunit 7C, mitochondrial OS=Homo sapiens GN=COX7C PE=1 SV=1",6435]
["H7BXZ6","RHOT1","H7BXZ6_HUMAN Mitochondrial Rho GTPase OS=Homo sapiens GN=RHOT1 PE=1 SV=2",69432]
["J3QTA6","CHCHD6","J3QTA6_HUMAN MICOS complex subunit OS=Homo sapiens GN=CHCHD6 PE=1 SV=1",29085]
["H0YBD2","COX7A2L","H0YBD2_HUMAN Cytochrome c oxidase subunit 7A-related protein, mitochondrial (Fragment) OS=Homo sapiens GN=COX7A2L PE=1 SV=1",10408]
["O95847","SLC25A27","UCP4_HUMAN Mitochondrial uncoupling protein 4 OS=Homo sapiens GN=SLC25A27 PE=2 SV=1",36212]
["Q9NZJ7","MTCH1","MTCH1_HUMAN Mitochondrial carrier homolog 1 OS=Homo sapiens GN=MTCH1 PE=1 SV=1",41859]
["Q3SXZ0","C9orf126","Q3SXZ0_HUMAN C9orf126 protein OS=Homo sapiens GN=C9orf126 PE=1 SV=1",56613]
["Q9BR01","SULT4A1","ST4A1_HUMAN Sulfotransferase 4A1 OS=Homo sapiens GN=SULT4A1 PE=1 SV=2",33462]
["P28288","ABCD3","ABCD3_HUMAN ATP-binding cassette sub-family D member 3 OS=Homo sapiens GN=ABCD3 PE=1 SV=1",75941]
["P05165","PCCA","PCCA_HUMAN Propionyl-CoA carboxylase alpha chain, mitochondrial OS=Homo sapiens GN=PCCA PE=1 SV=4",80635]
["H0YB09","C14orf159","H0YB09_HUMAN UPF0317 protein C14orf159, mitochondrial (Fragment) OS=Homo sapiens GN=C14orf159 PE=1 SV=1",61565]
["A0A0A0MRU0","MPP2","A0A0A0MRU0_HUMAN MAGUK p55 subfamily member 2 OS=Homo sapiens GN=MPP2 PE=1 SV=1",63623]
["F5H6L7","SLC8A2","F5H6L7_HUMAN Sodium/calcium exchanger 2 OS=Homo sapiens GN=SLC8A2 PE=1 SV=1",75094]
["Q8TBB6","SLC7A14","S7A14_HUMAN Probable cationic amino acid transporter OS=Homo sapiens GN=SLC7A14 PE=2 SV=3",84738]
["A0A087WWM6","PRODH","A0A087WWM6_HUMAN Proline dehydrogenase 1, mitochondrial OS=Homo sapiens GN=PRODH PE=1 SV=1",68556]
["Q9NVH0","EXD2","EXD2_HUMAN Exonuclease 3~-5~ domain-containing protein 2 OS=Homo sapiens GN=EXD2 PE=1 SV=2",71221]
["Q8TD22","SFXN5","SFXN5_HUMAN Sideroflexin-5 OS=Homo sapiens GN=SFXN5 PE=1 SV=1",37272]
["P03928","MT-ATP8","ATP8_HUMAN ATP synthase protein 8 OS=Homo sapiens GN=MT-ATP8 PE=1 SV=1",8043]
["A0A0D9SF28","NBEA","A0A0D9SF28_HUMAN Neurobeachin OS=Homo sapiens GN=NBEA PE=1 SV=1",330108]
["P13521","SCG2","SCG2_HUMAN Secretogranin-2 OS=Homo sapiens GN=SCG2 PE=1 SV=2",70897]
["A0A087WZX2","NDUFB6","A0A087WZX2_HUMAN NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 OS=Homo sapiens GN=NDUFB6 PE=1 SV=1",11708]