{"text_format":"3","workbook":"xlsx","n_sheets":1,"sheets":["Supplement File 2_RNAseq_FPKM_a"],"cells_cut":1,"read":"whole","date_system":"1900"}

{"sheet":"Supplement File 2_RNAseq_FPKM_a","index":0,"n_rows":25018,"n_cols":41,"rows_kept":2250,"cut":true,"bounds":{"rows_first":1000,"rows_last":250,"rows_between":1000,"halvings":1}}
["id","Donor1-1-L","Donor1-1-M","Donor1-1-S","Donor1-1-Unsorted","Donor1-3-L","Donor1-3-M","Donor1-3-S","Donor1-3-Unsorted","Donor4-2-L","Donor4-2-M","Donor4-2-S","Donor4-2-Unsorted","Donor4-3-L","Donor4-3-M","Donor4-3-S","Donor4-3-Unsorted","Donor5-1-L","Donor5-1-M","Donor5-1-S","Donor5-1-Unsorted","Donor5-2-L","Donor5-2-M","Donor5-2-S","Donor5-2-Unsorted","Donor5-3-L","Donor5-3-M","Donor5-3-S","Donor5-3-Unsorted","gene_Dbxref","description","coding_type","pathway","pathway_description","GO_ID","GO_term","wiki_ID","wiki_term","Reactome_ID","Reactome_term","TF_family"]
["A1BG",2.56649949903852,1.97870976601979,2.93333063290915,2.89714002051669,1.87701224000968,2.21547158658942,3.1381608726563,3.39989165278428,1.64353376036035,1.56602815797362,1.79149382667914,1.92455533178528,2.2739611184486,2.32526079751581,2.14221714670602,1.83640939667554,3.31048013474792,2.66968434018152,3.33702530586625,2.1997394399773,2.888818831244,3.08353358197536,2.7461531217057,3.69101701305078,3.35840701610118,2.68098508568832,3.43995426970577,3.31198902300374,1,"alpha-1-B glycoprotein","protein_coding",null,null,"GO:0003674,GO:0005576,GO:0005615,GO:0005886,GO:0008150,GO:0031093,GO:0034774,GO:0062023,GO:0070062,GO:0072562,GO:1904813","molecular_function|extracellular region|extracellular space|plasma membrane|biological_process|platelet alpha granule lumen|secretory granule lumen|collagen-containing extracellular matrix|extracellular exosome|blood microparticle|ficolin-1-rich granule lumen",null,null,"R-HSA-109582,R-HSA-114608,R-HSA-168249,R-HSA-168256,R-HSA-6798695,R-HSA-76002,R-HSA-76005","Hemostasis|Platelet degranulation |Innate Immune System|Immune System|Neutrophil degranulation|Platelet activation, signaling and aggregation|Response to elevated platelet cytosolic Ca2+"]
["A1BG-AS1",3.37901852948822,3.20196976243159,4.24167282214484,3.70189515597406,3.7222930164018,3.60090034017124,4.12080609315348,4.23179088799666,2.66051097241634,3.21786133846643,2.89212918774316,2.92847146005967,2.62368850949188,3.54724817124851,2.75407336825607,2.68785137622577,4.85483120595469,4.48481070726425,4.56162841145775,4.36895722984274,4.1090509326339,4.73963060323543,3.79810446576138,3.27648043581397,4.93095397258491,4.47330052285725,4.34750573249063,5.09218752027895,503538,"A1BG antisense RNA 1","non_coding"]
["A1CF",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.00279534861236446,0,0,0,0,0,29974,"APOBEC1 complementation factor","protein_coding",null,null,"GO:0003723,GO:0003725,GO:0003727,GO:0003729,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005783,GO:0006397,GO:0007566,GO:0010609,GO:0016554,GO:0016556,GO:0030895,GO:0045293,GO:0050821,GO:0140767,GO:1901537,GO:2000623","RNA binding|double-stranded RNA binding|single-stranded RNA binding|mRNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|endoplasmic reticulum|mRNA processing|embryo implantation|mRNA localization resulting in post-transcriptional regulation of gene expression|cytidine to uridine editing|mRNA modification|apolipoprotein B mRNA editing enzyme complex|mRNA editing complex|protein stabilization|enzyme-substrate adaptor activity|positive regulation of DNA demethylation|negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay",null,null,"R-HSA-72200,R-HSA-75072,R-HSA-75094,R-HSA-8953854","mRNA Editing: C to U Conversion|mRNA Editing|Formation of the Editosome|Metabolism of RNA"]
["A2M",0.0463253651168967,0.029375405453587,4.83243454175098E-3,0.0345556721408973,0.0352078196949959,0.0580025048318779,0.0480234970064607,0.020189559381354,0.238162636555821,0.203256426221548,0.285601481562956,0.264107275743897,0.127270033140743,0.235549675340199,0.196263949682325,0.195215480214984,0.0494878138093156,0.028575485854984,0.0333004703293797,0.0445474535411922,0.0534407810212288,0.0587119559376409,5.08148153326516E-3,0.0553160830312049,0.0765467377716532,0.014672476414233,0.0249045583300972,0.0338731580680239,2,"alpha-2-macroglobulin","protein_coding","hsa04610","Complement and coagulation cascades","GO:0001553,GO:0001869,GO:0002020,GO:0002438,GO:0004866,GO:0004867,GO:0005102,GO:0005515,GO:0005576,GO:0005615,GO:0006953,GO:0007584,GO:0010037,GO:0019838,GO:0019899,GO:0019959,GO:0019966,GO:0031093,GO:0034695,GO:0042802,GO:0043120,GO:0048306,GO:0048403,GO:0048406,GO:0048863,GO:0051384,GO:0062023,GO:0070062,GO:0072562,GO:1990402","luteinization|negative regulation of complement activation, lectin pathway|protease binding|acute inflammatory response to antigenic stimulus|endopeptidase inhibitor activity|serine-type endopeptidase inhibitor activity|signaling receptor binding|protein binding|extracellular region|extracellular space|acute-phase response|response to nutrient|response to carbon dioxide|growth factor binding|enzyme binding|interleukin-8 binding|interleukin-1 binding|platelet alpha granule lumen|response to prostaglandin E|identical protein binding|tumor necrosis factor binding|calcium-dependent protein binding|brain-derived neurotrophic factor binding|nerve growth factor binding|stem cell differentiation|response to glucocorticoid|collagen-containing extracellular matrix|extracellular exosome|blood microparticle|embryonic liver development",null,null,"R-HSA-109582,R-HSA-114608,R-HSA-140837,R-HSA-140877,R-HSA-1474228,R-HSA-1474244,R-HSA-174824,R-HSA-382551,R-HSA-76002,R-HSA-76005,R-HSA-8963896,R-HSA-8963898","Hemostasis|Platelet degranulation |Intrinsic Pathway of Fibrin Clot Formation|Formation of Fibrin Clot (Clotting Cascade)|Degradation of the extracellular matrix|Extracellular matrix organization|Plasma lipoprotein assembly, remodeling, and clearance|Transport of small molecules|Platelet activation, signaling and aggregation|Response to elevated platelet cytosolic Ca2+|HDL assembly|Plasma lipoprotein assembly"]
["A2M-AS1",0,0.0445910140175174,0.0110032433457173,0,0.022904764191639,0.0440230605513832,0,0,0.0353664762091541,0,0.0220441408834959,0.0589569396023355,0.0111457050762219,0.0111736743637375,0.0108996214685719,0.0777870031434905,0,0.0108441898132283,0.0433278417676924,0.011270290540832,0.0110620304430108,0.0334211427440679,0.0231406250345301,0.0343506316404451,0,0.0111361969538171,0,0.0110182440249839,144571,"A2M antisense RNA 1","non_coding"]
["A2ML1",0,0,0,0,0,0,0,0.00449467448053695,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.00454429819996767,0,0,0,144568,"alpha-2-macroglobulin like 1","protein_coding",null,null,"GO:0004867,GO:0005615,GO:0030414,GO:0052548,GO:0070062","serine-type endopeptidase inhibitor activity|extracellular space|peptidase inhibitor activity|regulation of endopeptidase activity|extracellular exosome"]
["A3GALT2",0.0527003230405535,0.0250633754252908,0.0494769495506351,0.0252713385004719,0.0257482686416274,0,0.02458446273928,0.155033317419576,0.0795140716334844,0.0507571658737929,0.0247808035347217,0.0530209036501942,0.0751763098982714,0,0,0,0.0506681683126854,0,0,0,0.0248706451797898,0,0,0,0,0,0.0254985673459861,0,127550,"alpha 1%2C3-galactosyltransferase 2","protein_coding","hsa00603","Glycosphingolipid biosynthesis - globo and isoglobo series","GO:0001962,GO:0005794,GO:0005975,GO:0006688,GO:0016757,GO:0030259,GO:0031982,GO:0032580,GO:0046872,GO:0047276","alpha-1,3-galactosyltransferase activity|Golgi apparatus|carbohydrate metabolic process|glycosphingolipid biosynthetic process|glycosyltransferase activity|lipid glycosylation|vesicle|Golgi cisterna membrane|metal ion binding|N-acetyllactosaminide 3-alpha-galactosyltransferase activity","WP5194,WP5292,WP1423","Synthesis of ceramides and 1-deoxyceramides|Glycosphingolipid metabolism|Ganglio sphingolipid metabolism"]
["A4GALT",1.7400701696681,2.2067939075152,1.41023637473662,1.88278094662053,1.58406189871555,1.77367392924952,1.7622278529931,1.46567429093175,0.695622001024191,1.0313296026483,1.32173628166285,0.935179041968081,0.643529951021589,1.19812613108545,0.892115224751807,0.726216395849967,1.12246416287844,1.33480758473448,1.29206612278277,1.26569249080627,1.23528549609125,1.24403481221137,1.00573944115592,0.893590224467303,0.980531684403672,1.25063331859281,1.07218486202665,1.45410425973856,53947,"alpha 1%2C4-galactosyltransferase (P blood group)","protein_coding","hsa00601,hsa00603","Glycosphingolipid biosynthesis - lacto and neolacto series|Glycosphingolipid biosynthesis - globo and isoglobo series","GO:0000139,GO:0001576,GO:0006493,GO:0006688,GO:0007009,GO:0008375,GO:0008378,GO:0015643,GO:0016020,GO:0050512","Golgi membrane|globoside biosynthetic process|protein O-linked glycosylation|glycosphingolipid biosynthetic process|plasma membrane organization|acetylglucosaminyltransferase activity|galactosyltransferase activity|toxic substance binding|membrane|lactosylceramide 4-alpha-galactosyltransferase activity","WP5194,WP5292","Synthesis of ceramides and 1-deoxyceramides|Glycosphingolipid metabolism"]
["A4GNT",0,0,0,0,0,0,0,0,0,0,0,0.0102611396962067,9.69925148517237E-3,0,0,0,0.00980581463940166,0,0,0,0,0,0,0.00996423921970283,0,0,0,0,51146,"alpha-1%2C4-N-acetylglucosaminyltransferase","protein_coding",null,null,"GO:0000139,GO:0005975,GO:0006493,GO:0008375,GO:0009101,GO:0016020,GO:0016266,GO:0050673,GO:0050680","Golgi membrane|carbohydrate metabolic process|protein O-linked glycosylation|acetylglucosaminyltransferase activity|glycoprotein biosynthetic process|membrane|O-glycan processing|epithelial cell proliferation|negative regulation of epithelial cell proliferation",null,null,"R-HSA-392499,R-HSA-5173105,R-HSA-597592,R-HSA-913709","Metabolism of proteins|O-linked glycosylation|Post-translational protein modification|O-linked glycosylation of mucins"]
["AAAS",24.2041029866154,24.4411949750503,24.8722964978125,28.06137031579,20.7072114531021,22.1984094687899,19.9199143113841,20.7942914711098,18.8386823568697,24.0231402327428,24.1247713758044,21.7136412699843,15.4830073955126,18.7947086839374,16.3265904383617,15.8213282819523,20.7640522434607,23.7086271322311,27.898846206462,21.3112049506652,20.2885127931675,24.3286523779628,19.547673071216,21.2693352172406,21.5552131051739,23.810278172616,22.7630821372319,25.532604705934,8086,"aladin WD repeat nucleoporin","protein_coding","hsa03013","Nucleocytoplasmic transport","GO:0000922,GO:0001578,GO:0003674,GO:0005515,GO:0005634,GO:0005635,GO:0005643,GO:0005654,GO:0005813,GO:0005829,GO:0006913,GO:0007612,GO:0009566,GO:0015031,GO:0016020,GO:0031965,GO:0046822,GO:0051028,GO:0072686,GO:0090307","spindle pole|microtubule bundle formation|molecular_function|protein binding|nucleus|nuclear envelope|nuclear pore|nucleoplasm|centrosome|cytosol|nucleocytoplasmic transport|learning|fertilization|protein transport|membrane|nuclear membrane|regulation of nucleocytoplasmic transport|mRNA transport|mitotic spindle|mitotic spindle assembly","WP3998","Prader-Willi and Angelman syndrome","R-HSA-1169408,R-HSA-1169410,R-HSA-1280215,R-HSA-1430728,R-HSA-159227,R-HSA-159230,R-HSA-159231,R-HSA-159234,R-HSA-159236,R-HSA-162582,R-HSA-162587,R-HSA-162599,R-HSA-162906,R-HSA-162906,R-HSA-162909,R-HSA-162909,R-HSA-1640170,R-HSA-1643685,R-HSA-1643685,R-HSA-165054,R-HSA-168255,R-HSA-168256,R-HSA-168271,R-HSA-168273,R-HSA-168274,R-HSA-168276,R-HSA-168325,R-HSA-168333,R-HSA-170822,R-HSA-176033,R-HSA-177243,R-HSA-177243,R-HSA-180746,R-HSA-180910,R-HSA-191859,R-HSA-194315,R-HSA-194441,R-HSA-211000,R-HSA-2262752,R-HSA-2980766,R-HSA-2990846,R-HSA-2990846,R-HSA-3108214,R-HSA-3108232,R-HSA-3108232,R-HSA-3232142,R-HSA-3301854,R-HSA-3371453,R-HSA-3371556,R-HSA-392499,R-HSA-392499,R-HSA-4085377,R-HSA-4551638,R-HSA-4570464,R-HSA-4615885,R-HSA-4615885,R-HSA-5578749,R-HSA-5619102,R-HSA-5619107,R-HSA-5619115,R-HSA-5663205,R-HSA-5663205,R-HSA-597592,R-HSA-597592,R-HSA-6784531,R-HSA-68875,R-HSA-68886,R-HSA-69278,R-HSA-70171,R-HSA-70326,R-HSA-71387,R-HSA-72202,R-HSA-72203,R-HSA-72306,R-HSA-74160,R-HSA-8953854,R-HSA-8953897,R-HSA-8980692,R-HSA-9012999,R-HSA-913531,R-HSA-9609646,R-HSA-9609690,R-HSA-9610379,R-HSA-9679506,R-HSA-9694516,R-HSA-9705671,R-HSA-9705683,R-HSA-9716542,R-HSA-9824446,R-HSA-9824446","ISG15 antiviral mechanism|Antiviral mechanism by IFN-stimulated genes|Cytokine Signaling in Immune system|Metabolism|Transport of the SLBP independent Mature mRNA|Transport of the SLBP Dependant Mature mRNA|Transport of Mature mRNA Derived from an Intronless Transcript|Transport of Mature mRNAs Derived from Intronless Transcripts|Transport of Mature mRNA derived from an Intron-Containing Transcript|Signal Transduction|HIV Life Cycle|Late Phase of HIV Life Cycle|HIV Infection|HIV Infection|Host Interactions of HIV factors|Host Interactions of HIV factors|Cell Cycle|Disease|Disease|Rev-mediated nuclear export of HIV RNA|Influenza Infection|Immune System|Transport of Ribonucleoproteins into the Host Nucleus|Influenza Viral RNA Transcription and Replication|Export of Viral Ribonucleoproteins from Nucleus|NS1 Mediated Effects on Host Pathways|Viral Messenger RNA Synthesis|NEP/NS2 Interacts with the Cellular Export Machinery|Regulation of Glucokinase by Glucokinase Regulatory Protein|Interactions of Vpr with host cellular proteins|Interactions of Rev with host cellular proteins|Interactions of Rev with host cellular proteins|Nuclear import of Rev protein|Vpr-mediated nuclear import of PICs|snRNP Assembly|Signaling by Rho GTPases|Metabolism of non-coding RNA|Gene Silencing by RNA|Cellular responses to stress|Nuclear Envelope Breakdown|SUMOylation|SUMOylation|SUMOylation of DNA damage response and repair proteins|SUMO E3 ligases SUMOylate target proteins|SUMO E3 ligases SUMOylate target proteins|SUMOylation of ubiquitinylation proteins|Nuclear Pore Complex (NPC) Disassembly|Regulation of HSF1-mediated heat shock response|Cellular response to heat stress|Metabolism of proteins|Metabolism of proteins|SUMOylation of SUMOylation proteins|SUMOylation of chromatin organization proteins|SUMOylation of RNA binding proteins|SUMOylation of DNA replication proteins|SUMOylation of DNA replication proteins|Transcriptional regulation by small RNAs|SLC transporter disorders|Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)|Disorders of transmembrane transporters|Infectious disease|Infectious disease|Post-translational protein modification|Post-translational protein modification|tRNA processing in the nucleus|Mitotic Prophase|M Phase|Cell Cycle, Mitotic|Glycolysis|Glucose metabolism|Metabolism of carbohydrates|Transport of Mature Transcript to Cytoplasm|Processing of Capped Intron-Containing Pre-mRNA|tRNA processing|Gene expression (Transcription)|Metabolism of RNA|Cellular responses to stimuli|RHOA GTPase cycle|RHO GTPase cycle|Interferon Signaling|HCMV Infection|HCMV Early Events|HCMV Late Events|SARS-CoV Infections|SARS-CoV-2 Infection|SARS-CoV-2 activates/modulates innate and adaptive immune responses|SARS-CoV-2-host interactions|Signaling by Rho GTPases, Miro GTPases and RHOBTB3|Viral Infection Pathways|Viral Infection Pathways"]
["AACS",11.0257121771878,13.1071868436761,15.25101470126,12.6984285468048,11.8284253561513,13.6587234029232,14.8555013267924,14.0339892326881,11.3009997925576,13.8848221441758,13.3608437993008,12.3973391371747,12.2316370826026,14.4813757559069,14.1336860280099,13.1114710023457,11.1193543412081,11.8187737080054,11.0759789113945,10.9820512607916,11.9041593216721,12.294693463603,10.1453699359634,11.4642367981571,11.4022483703633,12.7339267946366,10.5213015934192,11.8343249015281,65985,"acetoacetyl-CoA synthetase","protein_coding","hsa00650,hsa00280","Butanoate metabolism|Valine, leucine and isoleucine degradation","GO:0005515,GO:0005524,GO:0005829,GO:0006631,GO:0030729,GO:0032024,GO:0046951","protein binding|ATP binding|cytosol|fatty acid metabolic process|acetoacetate-CoA ligase activity|positive regulation of insulin secretion|ketone body biosynthetic process",null,null,"R-HSA-1430728,R-HSA-556833,R-HSA-74182,R-HSA-77111","Metabolism|Metabolism of lipids|Ketone body metabolism|Synthesis of Ketone Bodies"]
["AADACL4",0,0,0,0.0102143734832014,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,343066,"arylacetamide deacetylase like 4","protein_coding",null,null,"GO:0016020,GO:0052689","membrane|carboxylic ester hydrolase activity"]
["AADAT",5.31201302230909,5.19818926769005,4.60673531524939,5.08589485619367,4.78597878366378,4.59933645306368,4.59485579295559,4.82930855015387,6.65631574611168,5.43699266732366,5.31739430396151,5.77911911639727,6.45587232571281,5.6051240904801,6.10400645168824,5.54025477585115,4.77824181254178,3.98199808973388,4.27706868217818,4.69256652912533,4.40190483293358,4.5785700452656,4.47972821309741,4.65312998407142,4.39168627765292,4.11488800601467,4.53046689558142,3.74966227022582,51166,"aminoadipate aminotransferase","protein_coding","hsa00310,hsa00380","Lysine degradation|Tryptophan metabolism","GO:0005759,GO:0006103,GO:0006536,GO:0009058,GO:0016212,GO:0030170,GO:0033512,GO:0042803,GO:0047315,GO:0047536,GO:0047958,GO:0050094,GO:0070189,GO:0097052,GO:1901605","mitochondrial matrix|2-oxoglutarate metabolic process|glutamate metabolic process|biosynthetic process|kynurenine-oxoglutarate transaminase activity|pyridoxal phosphate binding|L-lysine catabolic process to acetyl-CoA via saccharopine|protein homodimerization activity|kynurenine-glyoxylate transaminase activity|2-aminoadipate transaminase activity|glycine:2-oxoglutarate aminotransferase activity|methionine-glyoxylate transaminase activity|kynurenine metabolic process|L-kynurenine metabolic process|alpha-amino acid metabolic process","WP465,WP5044,WP5355,WP4210,WP5414","Tryptophan metabolism|Kynurenine pathway and links to cell senescence|Metabolic Epileptic Disorders|Tryptophan catabolism leading to NAD+ production|IDO metabolic pathway","R-HSA-1430728,R-HSA-71064,R-HSA-71240,R-HSA-71291","Metabolism|Lysine catabolism|Tryptophan catabolism|Metabolism of amino acids and derivatives"]
["AAGAB",16.2930173035468,15.4973626698765,16.7646555724751,16.3653942269065,15.2385284918794,15.1223845749968,15.3437496139619,16.6830030950535,15.7447302252949,12.2876031473709,15.4320882644743,15.9969617340864,15.1417380861454,15.7761066131291,15.9979738203716,15.027566249874,21.2173433326879,19.9613853394174,20.5170074252896,17.3463942916638,18.8176898332092,19.2344418026797,20.6517278033472,20.4728899477497,19.9031432516641,19.2548631518266,21.9252245386535,19.3928230237898,79719,"alpha and gamma adaptin binding protein","protein_coding",null,null,"GO:0005515,GO:0005737,GO:0005829,GO:0015031,GO:0016607","protein binding|cytoplasm|cytosol|protein transport|nuclear speck"]
["AAK1",3.12919906497882,2.90852197117616,2.63158346312472,2.89721914671575,3.10876663111504,2.73029535862823,2.29543258936472,2.65493731708561,2.84894292211851,2.2861344666872,2.58815739257002,2.78034205789262,2.82317122009139,2.38446010232257,2.53570623757201,2.65648873928137,2.43769761794951,2.63244668250505,1.96298244223554,2.76651353664306,2.51937390412855,2.66680404502224,2.12445966043482,2.14721890364837,2.47961477395667,2.43699382126379,1.86171961697618,2.22911518174309,22848,"AP2 associated kinase 1","protein_coding",null,null,"GO:0004674,GO:0005112,GO:0005515,GO:0005524,GO:0005829,GO:0005886,GO:0005905,GO:0006468,GO:0030136,GO:0031252,GO:0032880,GO:0035612,GO:0043195,GO:0043231,GO:0045747,GO:0050821,GO:0061024,GO:0106310,GO:0140238,GO:2000369","protein serine/threonine kinase activity|Notch binding|protein binding|ATP binding|cytosol|plasma membrane|clathrin-coated pit|protein phosphorylation|clathrin-coated vesicle|cell leading edge|regulation of protein localization|AP-2 adaptor complex binding|terminal bouton|intracellular membrane-bounded organelle|positive regulation of Notch signaling pathway|protein stabilization|membrane organization|protein serine kinase activity|presynaptic endocytosis|regulation of clathrin-dependent endocytosis","WP5323","Fatty Acids and Lipoproteins Transport in Hepatocytes","R-HSA-199991,R-HSA-5653656,R-HSA-8856825,R-HSA-8856828","Membrane Trafficking|Vesicle-mediated transport|Cargo recognition for clathrin-mediated endocytosis|Clathrin-mediated endocytosis"]
["AAMDC",1.95441779407371,1.72646998717314,2.2387812042221,1.83510480719774,1.89375991519106,1.71602278133488,2.42744944790241,2.05711939161869,2.15546102406604,1.7876451627958,2.74353892011042,2.46921950722412,2.13138950545598,2.69143057671604,2.62541877811916,2.34646396037038,3.1278178849368,2.92672798789607,3.79060989898762,2.62408132701726,2.85403411976997,3.3610795071541,3.76989237148645,3.14232484302698,2.77040007310453,3.17294439731422,4.1750328648542,3.27030325392705,28971,"adipogenesis associated Mth938 domain containing","protein_coding",null,null,"GO:0005515,GO:0005737,GO:0045600","protein binding|cytoplasm|positive regulation of fat cell differentiation"]
["AAMP",49.4219686806751,40.4354873496006,46.7651561947782,49.9644612135577,42.4863384065459,44.6296126948904,46.5492762462114,46.4063819364255,38.4603814096956,42.9251832876984,47.0348302741125,43.5952017534317,36.3238806381832,42.5931550097803,39.8105276501976,37.0440165023485,43.7159649311403,49.3483652243774,48.2489553669681,46.18064786397,45.3780488716587,46.3000898374138,40.6674844746486,44.38284354448,45.5591573797933,44.4559204081558,42.4646145960581,48.5478669276386,14,"angio associated migratory cell protein","protein_coding",null,null,"GO:0001525,GO:0005515,GO:0005829,GO:0005886,GO:0008201,GO:0009986,GO:0010595,GO:0014909,GO:0015630,GO:0030154,GO:0045171","angiogenesis|protein binding|cytosol|plasma membrane|heparin binding|cell surface|positive regulation of endothelial cell migration|smooth muscle cell migration|microtubule cytoskeleton|cell differentiation|intercellular bridge","WP1433","Nucleotide-binding oligomerization domain (NOD) pathway","R-HSA-109582,R-HSA-162582,R-HSA-168249,R-HSA-168256,R-HSA-168638,R-HSA-168643,R-HSA-177929,R-HSA-194138,R-HSA-392518,R-HSA-428930,R-HSA-76002,R-HSA-9006934","Hemostasis|Signal Transduction|Innate Immune System|Immune System|NOD1/2 Signaling Pathway|Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways|Signaling by EGFR|Signaling by VEGF|Signal amplification|Thromboxane signalling through TP receptor|Platelet activation, signaling and aggregation|Signaling by Receptor Tyrosine Kinases"]
["AANAT",0.00535695851256818,0.0101907126629859,0.0804688702548486,0,0.0104691887203437,0.0352131992685448,0,0.0157590504491481,0,0,0,0.00538954535315468,0.0152832601402884,0,0.00498194145026143,0,0.00515039111525011,0,0.00495101530533051,0.0103027298266747,0,0.00509198650711157,0,0.00523360180001482,0,0.00509007412435998,0,0.00503616082223033,15,"aralkylamine N-acetyltransferase","protein_coding","hsa00380","Tryptophan metabolism","GO:0004059,GO:0004060,GO:0005515,GO:0005737,GO:0005829,GO:0006474,GO:0007623,GO:0009416,GO:0009648,GO:0010043,GO:0030187,GO:0032868,GO:0034097,GO:0034695,GO:0046219,GO:0046688,GO:0048471,GO:0051412,GO:0051592,GO:0071320,GO:0071889","aralkylamine N-acetyltransferase activity|arylamine N-acetyltransferase activity|protein binding|cytoplasm|cytosol|N-terminal protein amino acid acetylation|circadian rhythm|response to light stimulus|photoperiodism|response to zinc ion|melatonin biosynthetic process|response to insulin|response to cytokine|response to prostaglandin E|indolalkylamine biosynthetic process|response to copper ion|perinuclear region of cytoplasm|response to corticosterone|response to calcium ion|cellular response to cAMP|14-3-3 protein binding","WP465,WP4156,WP3594,WP3298,WP550","Tryptophan metabolism|Biosynthesis and regeneration of tetrahydrobiopterin and catabolism of phenylalanine|Circadian rhythm genes|Melatonin metabolism and effects|Biogenic amine synthesis","R-HSA-1430728,R-HSA-209776,R-HSA-209931,R-HSA-71291","Metabolism|Metabolism of amine-derived hormones|Serotonin and melatonin biosynthesis|Metabolism of amino acids and derivatives"]
["AAR2",10.8077970943181,10.4645828827338,11.0259730502812,11.3524784783204,9.69527483341865,11.2344921504132,11.6264194834531,10.9621171585446,12.2205288685152,14.0253249247299,14.9882909071244,13.3775971624754,11.5297871196936,11.0358831994398,11.4086116166505,11.2553776379454,12.4027350274097,12.6933023672962,13.7472664776068,12.0805521174296,11.2839635107407,12.157834170059,11.227729868084,10.5012228307597,11.618481879424,12.2574847660371,11.9770721306361,13.2301694452107,25980,"AAR2 splicing factor","protein_coding",null,null,"GO:0000244,GO:0005515,GO:0005681,GO:0005682","spliceosomal tri-snRNP complex assembly|protein binding|spliceosomal complex|U5 snRNP","WP4352","Ciliary landscape"]
["AARD",0.0117661349782815,0.0111915465124716,0.0110464686578567,0.0225688164871084,0,0.0662940021397958,0.0109776976788666,0,0.106516231271568,0.0453291843639372,0.0663922182872641,0.130214803312011,0.145463370484084,0.0560878459986825,0.0547121985545952,0.0334682497780186,0.067874556329826,0.054433951484996,0.217490257672833,0.0226291298506449,0.177687787124749,0.257235334084271,0.092926124101998,0.0229903834637054,0.0816565360096329,0.0558997228148831,0.113858727171295,0.165922923990373,441376,"alanine and arginine rich domain containing protein","protein_coding",null,null,"GO:0005515","protein binding"]
["AARS1",71.81788272014,84.4018246266106,112.981571592196,90.8037058889683,78.5232894948103,95.1033238340142,120.085858955092,99.0725146195307,88.2614986329588,87.9258247335876,91.7923285683367,86.5605204018928,91.382458762265,108.787114673098,110.436918215883,110.64481007006,48.2442485458897,52.1038552736843,43.2742650067052,50.1388567022225,48.2870341965225,47.8239017182961,37.8696295026098,45.8131685704499,49.5699703016621,47.7761317844399,40.4974522931103,51.8341540994952,16,"alanyl-tRNA synthetase 1","protein_coding","hsa00970","Aminoacyl-tRNA biosynthesis","GO:0000049,GO:0002161,GO:0002196,GO:0004813,GO:0005524,GO:0005737,GO:0005739,GO:0005829,GO:0006400,GO:0006418,GO:0006419,GO:0008033,GO:0008270,GO:0016020,GO:0016597,GO:0021680,GO:0043524,GO:0050885,GO:0051402,GO:0070062,GO:0106074,GO:0140018","tRNA binding|aminoacyl-tRNA editing activity|Ser-tRNA(Ala) hydrolase activity|alanine-tRNA ligase activity|ATP binding|cytoplasm|mitochondrion|cytosol|tRNA modification|tRNA aminoacylation for protein translation|alanyl-tRNA aminoacylation|tRNA processing|zinc ion binding|membrane|amino acid binding|cerebellar Purkinje cell layer development|negative regulation of neuron apoptotic process|neuromuscular process controlling balance|neuron apoptotic process|extracellular exosome|aminoacyl-tRNA metabolism involved in translational fidelity|regulation of cytoplasmic translational fidelity","WP4754","IL-18 signaling pathway","R-HSA-379716,R-HSA-379724,R-HSA-392499,R-HSA-72766","Cytosolic tRNA aminoacylation|tRNA Aminoacylation|Metabolism of proteins|Translation"]
["AARS2",4.9117726023432,4.73000696746428,3.57917056489185,4.30550886144955,5.05820750761544,4.14399476234485,3.23396630765389,3.6235817843934,4.40300163278618,5.82386724493971,4.40383328072861,4.66512369897181,3.98370565309301,3.62005107124261,3.12890757527756,3.77394539959759,3.63108797662734,4.30921402226946,3.79629942905088,4.18486147064695,3.82408711009522,3.87052509120626,3.180743578906,3.2620992585035,4.00673415123184,3.65627251950477,3.13256832990639,3.45006685548165,57505,"alanyl-tRNA synthetase 2%2C mitochondrial","protein_coding","hsa00970","Aminoacyl-tRNA biosynthesis","GO:0000049,GO:0002161,GO:0004813,GO:0005515,GO:0005524,GO:0005739,GO:0006419,GO:0008270,GO:0070143,GO:0106074","tRNA binding|aminoacyl-tRNA editing activity|alanine-tRNA ligase activity|protein binding|ATP binding|mitochondrion|alanyl-tRNA aminoacylation|zinc ion binding|mitochondrial alanyl-tRNA aminoacylation|aminoacyl-tRNA metabolism involved in translational fidelity","WP5316","Primary ovarian insufficiency","R-HSA-379724,R-HSA-379726,R-HSA-392499,R-HSA-72766","tRNA Aminoacylation|Mitochondrial tRNA aminoacylation|Metabolism of proteins|Translation"]
["AARSD1",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.0188738704669872,0,0,0,0,0,0,0,0,0,80755,"PTGES3L-AARSD1 readthrough","protein_coding",null,null,"GO:0002196,GO:0003674,GO:0003676,GO:0004813,GO:0005524,GO:0005634,GO:0005737,GO:0006419,GO:0006450,GO:0008150,GO:0046872,GO:0106074","Ser-tRNA(Ala) hydrolase activity|molecular_function|nucleic acid binding|alanine-tRNA ligase activity|ATP binding|nucleus|cytoplasm|alanyl-tRNA aminoacylation|regulation of translational fidelity|biological_process|metal ion binding|aminoacyl-tRNA metabolism involved in translational fidelity"]
["AASDH",2.00785144266114,1.88669743196208,2.18528147239993,1.63058767083837,2.2072363991252,1.84746122106683,2.05837189267825,1.91331927599613,2.14992484899618,1.5010484731358,1.85019827898872,2.00377452632536,2.42915779803588,2.13422382087967,2.94399446964612,2.46028744630142,2.54536211625286,2.27355059291907,2.58151692766661,2.54973610148123,2.7089432412401,2.40875813800415,3.74857970036757,3.09666378942171,2.44012776244451,2.0924477592155,3.54120304745895,2.40518388867947,132949,"aminoadipate-semialdehyde dehydrogenase","protein_coding",null,null,"GO:0005524,GO:0006631,GO:0016878,GO:0019482,GO:0043041","ATP binding|fatty acid metabolic process|acid-thiol ligase activity|beta-alanine metabolic process|amino acid activation for nonribosomal peptide biosynthetic process"]
["AASDHPPT",9.25702434728842,8.99303324489763,7.94830863508486,6.94727013930944,8.99873659633952,7.93887743984241,7.65845084990627,8.07860043399689,8.05172320482247,5.41866873381505,5.88268405083913,6.63085384280546,8.92300523305986,6.37488049718638,7.63942573390708,7.67496125703388,6.307815305773,6.14255019338322,6.97733304305248,8.56181351643829,7.51008352636862,7.72843806909021,9.15055100415222,7.40484276193784,6.54611458564989,6.30226073885616,8.63896449176845,5.85811062630841,60496,"aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase","protein_coding","hsa00770","Pantothenate and CoA biosynthesis","GO:0000287,GO:0005515,GO:0005829,GO:0008897,GO:0009258,GO:0015939,GO:0019878,GO:0051604,GO:0070062","magnesium ion binding|protein binding|cytosol|holo-[acyl-carrier-protein] synthase activity|10-formyltetrahydrofolate catabolic process|pantothenate metabolic process|lysine biosynthetic process via aminoadipic acid|protein maturation|extracellular exosome",null,null,"R-HSA-1430728,R-HSA-196849,R-HSA-196854,R-HSA-199220","Metabolism|Metabolism of water-soluble vitamins and cofactors|Metabolism of vitamins and cofactors|Vitamin B5 (pantothenate) metabolism"]
["AASS",5.98105425219582,6.60499631137253,6.419875245744,5.38705882899367,6.64140277949874,6.10547172681214,5.66625218698283,5.31826557090333,7.59663848237313,5.50755595170194,5.62483574304178,6.61547252884873,8.85616767620558,6.76532557202707,7.88499112051223,8.34476934821377,5.63080551194084,5.96041161118879,4.72291991439542,6.50921891458279,5.84529034280944,5.86479164153311,7.07371328512795,6.84272411481459,7.44188954805505,5.29340561871442,5.60047917949562,4.48790972012508,10157,"aminoadipate-semialdehyde synthase","protein_coding","hsa00310","Lysine degradation","GO:0000122,GO:0003714,GO:0004753,GO:0004754,GO:0005634,GO:0005737,GO:0005739,GO:0005759,GO:0005829,GO:0006554,GO:0019878,GO:0033512,GO:0042393,GO:0043231,GO:0047130,GO:0047131","negative regulation of transcription by RNA polymerase II|transcription corepressor activity|saccharopine dehydrogenase activity|saccharopine dehydrogenase (NAD+, L-lysine-forming) activity|nucleus|cytoplasm|mitochondrion|mitochondrial matrix|cytosol|lysine catabolic process|lysine biosynthetic process via aminoadipic acid|L-lysine catabolic process to acetyl-CoA via saccharopine|histone binding|intracellular membrane-bounded organelle|saccharopine dehydrogenase (NADP+, L-lysine-forming) activity|saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity","WP5355","Metabolic Epileptic Disorders","R-HSA-1430728,R-HSA-71064,R-HSA-71291","Metabolism|Lysine catabolism|Metabolism of amino acids and derivatives"]
["AATBC",0,0.0111526024619715,0,5.62257052761696E-3,0.0114573635582361,0,0,0.00574884311005607,0.0471758128351773,0.0677571735827187,0.00551343236538067,0.017694775261249,0,0.00558926729808533,0,0.011117262612939,0.0450922454840166,0.0271222668229939,0.0162550080576923,0.0169127891978558,0.0055334210567475,0.0445809066616536,0.0115753452760807,0.0229103821293384,0.0290615677620811,0.00557052044231828,0.00567312622769547,0.0330691099488426,284837,"apoptosis associated transcript in bladder cancer","non_coding"]
["AATF",31.0087985150323,29.0344375340782,33.2728046719453,36.9734511708842,26.6981574852591,30.2114124198587,30.6506848815122,30.9968141315477,27.350989683898,27.1584191430494,32.284724080538,29.3560955521386,22.2908696235848,24.2287744011364,25.8958513940514,22.2986894074283,20.4493606622619,25.6069081569302,26.8949908198631,24.337705974887,22.1111855838572,25.5358925282633,20.5201905313474,21.8142614510709,22.8886427172363,25.1784984570276,25.0730059024144,25.2805113029105,26574,"apoptosis antagonizing transcription factor","protein_coding",null,null,"GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0005730,GO:0005737,GO:0006357,GO:0006974,GO:0007155,GO:0007346,GO:0019901,GO:0032040,GO:0032929,GO:0040016,GO:0042274,GO:0042985,GO:0043066,GO:0043522,GO:0045944,GO:0048156,GO:2000378,GO:2001234","RNA binding|protein binding|nucleus|nucleoplasm|transcription regulator complex|nucleolus|cytoplasm|regulation of transcription by RNA polymerase II|DNA damage response|cell adhesion|regulation of mitotic cell cycle|protein kinase binding|small-subunit processome|negative regulation of superoxide anion generation|embryonic cleavage|ribosomal small subunit biogenesis|negative regulation of amyloid precursor protein biosynthetic process|negative regulation of apoptotic process|leucine zipper domain binding|positive regulation of transcription by RNA polymerase II|tau protein binding|negative regulation of reactive oxygen species metabolic process|negative regulation of apoptotic signaling pathway","WP5287","17q12 copy number variation syndrome","R-HSA-162582,R-HSA-193648,R-HSA-193704,R-HSA-204998,R-HSA-73887","Signal Transduction|NRAGE signals death through JNK|p75 NTR receptor-mediated signalling|Cell death signalling via NRAGE, NRIF and NADE|Death Receptor Signaling"]
["AATK",0.068441605602721,0.055799419064358,0.0963831435615066,0.192229914893959,0.119425457110921,0.119358860218204,0.0364887999742959,0.0767012858035192,0.122933888406865,0.0565011759400328,0.091950533246356,0.103286912687443,0.0883328458162678,0.0978760376801819,0.0363716059161632,0.148326945213765,0.0188007022792445,0.0180933163369062,0.0406640517134218,0.0752170279112478,0.0738271164858179,0.0604093923375428,0.0482620942867422,0.0573133498534811,0.0581610831643305,0.0557415734358639,0.0804217600134284,0.0459593058713512,9625,"apoptosis associated tyrosine kinase","protein_coding",null,null,"GO:0004674,GO:0004713,GO:0005515,GO:0005524,GO:0005575,GO:0007420,GO:0008150,GO:0016020,GO:0016310,GO:0038083,GO:0048471,GO:0106310","protein serine/threonine kinase activity|protein tyrosine kinase activity|protein binding|ATP binding|cellular_component|brain development|biological_process|membrane|phosphorylation|peptidyl-tyrosine autophosphorylation|perinuclear region of cytoplasm|protein serine kinase activity"]
["ABALON",3.31463708094949,0.889242765089221,0.784624341573222,1.5758797673011,2.35306431921462,1.60951362998554,1.46696768125773,1.81962515040722,1.92350514327244,1.17328269554507,0.626109203758779,2.13769250265956,0.821724867153938,1.21542332805763,0.632326962758983,1.00730110669259,1.30741447021865,0.353875032791109,0.785502123481549,0.708316736039682,0.681858208599672,0.713616622964072,1.28653606340162,1.84057772268561,1.76949670623502,1.50745367067961,1.28848829906711,0.799010864659896,103021294,"apoptotic BCL2L1-antisense long non-coding RNA","non_coding"]
["ABAT",0.913994521489815,0.902958903835478,0.373082943908843,0.622494538090003,1.05707081261167,0.650971628382657,0.444912331087078,0.675442453190155,2.19845662921769,1.90092445273824,1.26234752708766,1.62143655351877,1.68381388891065,1.70066801290498,1.71644489433007,2.16860736036397,1.40090638334803,1.2542313557937,0.767197329252669,1.2313323162547,1.54198000114697,1.39761142384284,0.758466678035951,1.49255979576665,1.44459555210864,1.05305921399486,0.875910245858063,1.39474184807659,18,"4-aminobutyrate aminotransferase","protein_coding","hsa00640,hsa00650,hsa00250,hsa00280,hsa00410,hsa04727","Propanoate metabolism|Butanoate metabolism|Alanine, aspartate and glutamate metabolism|Valine, leucine and isoleucine degradation|beta-Alanine metabolism|GABAergic synapse","GO:0001666,GO:0003867,GO:0005739,GO:0005759,GO:0007620,GO:0007626,GO:0009410,GO:0009448,GO:0009449,GO:0009450,GO:0010039,GO:0014053,GO:0021549,GO:0030170,GO:0031652,GO:0032024,GO:0032144,GO:0032145,GO:0033602,GO:0034386,GO:0035094,GO:0035640,GO:0042135,GO:0042802,GO:0045471,GO:0045776,GO:0045964,GO:0046872,GO:0047298,GO:0048148,GO:0051536,GO:0070474,GO:0097151,GO:1902722,GO:1904450","response to hypoxia|4-aminobutyrate transaminase activity|mitochondrion|mitochondrial matrix|copulation|locomotory behavior|response to xenobiotic stimulus|gamma-aminobutyric acid metabolic process|gamma-aminobutyric acid biosynthetic process|gamma-aminobutyric acid catabolic process|response to iron ion|negative regulation of gamma-aminobutyric acid secretion|cerebellum development|pyridoxal phosphate binding|positive regulation of heat generation|positive regulation of insulin secretion|4-aminobutyrate transaminase complex|succinate-semialdehyde dehydrogenase binding|negative regulation of dopamine secretion|4-aminobutyrate:2-oxoglutarate transaminase activity|response to nicotine|exploration behavior|neurotransmitter catabolic process|identical protein binding|response to ethanol|negative regulation of blood pressure|positive regulation of dopamine metabolic process|metal ion binding|(S)-3-amino-2-methylpropionate transaminase activity|behavioral response to cocaine|iron-sulfur cluster binding|positive regulation of uterine smooth muscle contraction|positive regulation of inhibitory postsynaptic potential|positive regulation of prolactin secretion|positive regulation of aspartate secretion","WP4159,WP106,WP4157,WP4549,WP4225,WP3871","GABA receptor signaling|Alanine and aspartate metabolism|GABA metabolism (aka GHB)|Fragile X syndrome|Pyrimidine metabolism and related diseases|Valproic acid pathway","R-HSA-112310,R-HSA-112315,R-HSA-112316,R-HSA-888590,R-HSA-916853","Neurotransmitter release cycle|Transmission across Chemical Synapses|Neuronal System|GABA synthesis, release, reuptake and degradation|Degradation of GABA"]
["ABCA1",10.196639064292,10.4081758915071,7.10738899778277,5.43977215952174,13.1196235784853,10.1296817004221,7.75181557132641,7.54290415464184,8.86529184734271,5.62749106620562,3.30280873306337,5.20620138832768,11.1353175532358,6.99771754782033,9.11670394837175,10.9473654610665,5.51304040695158,4.61544888880082,3.45887975871747,6.71452897632509,5.3510765441417,4.76859252623294,5.97536383662101,5.74127726562871,5.95715229597452,3.35669456989961,4.80447837577894,3.62062801593462,19,"ATP binding cassette subfamily A member 1","protein_coding","hsa02010,hsa04975,hsa04979,hsa05417","ABC transporters|Fat digestion and absorption|Cholesterol metabolism|Lipid and atherosclerosis","GO:0002790,GO:0005102,GO:0005515,GO:0005524,GO:0005548,GO:0005768,GO:0005789,GO:0005794,GO:0005886,GO:0006911,GO:0007040,GO:0007186,GO:0007189,GO:0007584,GO:0008035,GO:0008203,GO:0008320,GO:0009306,GO:0009897,GO:0010745,GO:0010875,GO:0010887,GO:0015485,GO:0016197,GO:0016323,GO:0016887,GO:0019905,GO:0023061,GO:0030139,GO:0031210,GO:0031267,GO:0032367,GO:0032489,GO:0033344,GO:0033700,GO:0034185,GO:0034186,GO:0034188,GO:0034380,GO:0034616,GO:0038027,GO:0042158,GO:0042626,GO:0042632,GO:0043231,GO:0043691,GO:0045121,GO:0045332,GO:0045335,GO:0046623,GO:0048471,GO:0051117,GO:0055091,GO:0060155,GO:0071222,GO:0071300,GO:0071345,GO:0071397,GO:0071404,GO:0071466,GO:0071806,GO:0090107,GO:0090108,GO:0090554,GO:0090556,GO:0097708,GO:0099039,GO:0120009,GO:0120020,GO:0140115,GO:0140328,GO:0140359","peptide secretion|signaling receptor binding|protein binding|ATP binding|phospholipid transporter activity|endosome|endoplasmic reticulum membrane|Golgi apparatus|plasma membrane|phagocytosis, engulfment|lysosome organization|G protein-coupled receptor signaling pathway|adenylate cyclase-activating G protein-coupled receptor signaling pathway|response to nutrient|high-density lipoprotein particle binding|cholesterol metabolic process|protein transmembrane transporter activity|protein secretion|external side of plasma membrane|negative regulation of macrophage derived foam cell differentiation|positive regulation of cholesterol efflux|negative regulation of cholesterol storage|cholesterol binding|endosomal transport|basolateral plasma membrane|ATP hydrolysis activity|syntaxin binding|signal release|endocytic vesicle|phosphatidylcholine binding|small GTPase binding|intracellular cholesterol transport|regulation of Cdc42 protein signal transduction|cholesterol efflux|phospholipid efflux|apolipoprotein binding|apolipoprotein A-I binding|apolipoprotein A-I receptor activity|high-density lipoprotein particle assembly|response to laminar fluid shear stress|apolipoprotein A-I-mediated signaling pathway|lipoprotein biosynthetic process|ATPase-coupled transmembrane transporter activity|cholesterol homeostasis|intracellular membrane-bounded organelle|reverse cholesterol transport|membrane raft|phospholipid translocation|phagocytic vesicle|sphingolipid floppase activity|perinuclear region of cytoplasm|ATPase binding|phospholipid homeostasis|platelet dense granule organization|cellular response to lipopolysaccharide|cellular response to retinoic acid|cellular response to cytokine stimulus|cellular response to cholesterol|cellular response to low-density lipoprotein particle stimulus|cellular response to xenobiotic stimulus|protein transmembrane transport|regulation of high-density lipoprotein particle assembly|positive regulation of high-density lipoprotein particle assembly|phosphatidylcholine floppase activity|phosphatidylserine floppase activity|intracellular vesicle|sphingolipid translocation|intermembrane lipid transfer|cholesterol transfer activity|export across plasma membrane|floppase activity|ABC-type transporter activity","WP1533,WP5224,WP2011,WP5323,WP299,WP4718,WP15,WP430,WP5158,WP5304,WP176,WP5329,WP5333,WP4522","Vitamin B12 metabolism|2q37 copy number variation syndrome|SREBF and miR33 in cholesterol and lipid homeostasis|Fatty Acids and Lipoproteins Transport in Hepatocytes|Nuclear receptors in lipid metabolism and toxicity|Cholesterol metabolism with Bloch and Kandutsch-Russell pathways|Selenium micronutrient network|Statin inhibition of cholesterol production|Urotensin-II-mediated signaling pathway|Cholesterol metabolism|Folate metabolism|Cholesterol biosynthesis pathway in hepatocytes|Enterocyte cholesterol metabolism|Metabolic pathway of LDL, HDL and TG, including diseases","R-HSA-1430728,R-HSA-162582,R-HSA-1643685,R-HSA-174824,R-HSA-1989781,R-HSA-382551,R-HSA-400206,R-HSA-556833,R-HSA-5619084,R-HSA-5619115,R-HSA-5682113,R-HSA-8963896,R-HSA-8963898,R-HSA-9006931,R-HSA-9024446,R-HSA-9029569","Metabolism|Signal Transduction|Disease|Plasma lipoprotein assembly, remodeling, and clearance|PPARA activates gene expression|Transport of small molecules|Regulation of lipid metabolism by PPARalpha|Metabolism of lipids|ABC transporter disorders|Disorders of transmembrane transporters|Defective ABCA1 causes TGD|HDL assembly|Plasma lipoprotein assembly|Signaling by Nuclear Receptors|NR1H2 and NR1H3-mediated signaling|NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux"]
["ABCA10",0.0254144078270676,0.112808819246076,0.0795331857170015,0.0324985283293309,0.0951965765035907,0.0556859895409546,0.0474228259879638,0.0706103190667258,0.0596480480795497,0.00815911073049814,0.0717023438542373,0.029830506838391,0.0966755060036853,0.0928798513264796,0.0512097237445477,0.0843385169217607,0.016289609108698,0.0313534086366124,0.0078295125758715,0.0122195167711724,0.0159916216335166,0.0241573313360642,0.00836320515075728,0.0124145903163142,0.0335952453978753,0.0281729684092483,0.0204942130695661,0.0238924839008136,10349,"ATP binding cassette subfamily A member 10","protein_coding","hsa02010","ABC transporters","GO:0005319,GO:0005524,GO:0006869,GO:0016020,GO:0016887,GO:0042626,GO:0043231,GO:0055085,GO:0140359","lipid transporter activity|ATP binding|lipid transport|membrane|ATP hydrolysis activity|ATPase-coupled transmembrane transporter activity|intracellular membrane-bounded organelle|transmembrane transport|ABC-type transporter activity",null,null,"R-HSA-1369062,R-HSA-382551,R-HSA-382556","ABC transporters in lipid homeostasis|Transport of small molecules|ABC-family proteins mediated transport"]
["ABCA12",0.0170303560504852,0.00539956471729441,0.00266478463674317,0.0108887350893894,0.00832067352439239,0.0026653953687528,0.00264819473331404,0,0.0399705357458413,0.00820120785862222,0,2.85565886249071E-3,0.016195717600491,0,0.00791906793020391,5.38245482723952E-3,0.00272894262313768,0,0,0,0,0,0.00280211843631775,0,0.0112561936249383,0,0,0,26154,"ATP binding cassette subfamily A member 12","protein_coding","hsa02010","ABC transporters","GO:0000139,GO:0003336,GO:0005102,GO:0005319,GO:0005515,GO:0005524,GO:0005737,GO:0005829,GO:0005886,GO:0006672,GO:0006869,GO:0006886,GO:0010875,GO:0016020,GO:0016887,GO:0019725,GO:0030658,GO:0031424,GO:0032379,GO:0032940,GO:0033344,GO:0033700,GO:0034040,GO:0034191,GO:0034204,GO:0035627,GO:0042626,GO:0043129,GO:0043231,GO:0043589,GO:0045055,GO:0045616,GO:0048286,GO:0055085,GO:0055088,GO:0061178,GO:0061436,GO:0072659,GO:0097209,GO:0097234,GO:0140326,GO:0140359,GO:2000010","Golgi membrane|corneocyte desquamation|signaling receptor binding|lipid transporter activity|protein binding|ATP binding|cytoplasm|cytosol|plasma membrane|ceramide metabolic process|lipid transport|intracellular protein transport|positive regulation of cholesterol efflux|membrane|ATP hydrolysis activity|cellular homeostasis|transport vesicle membrane|keratinization|positive regulation of intracellular lipid transport|secretion by cell|cholesterol efflux|phospholipid efflux|ATPase-coupled lipid transmembrane transporter activity|apolipoprotein A-I receptor binding|lipid translocation|ceramide transport|ATPase-coupled transmembrane transporter activity|surfactant homeostasis|intracellular membrane-bounded organelle|skin morphogenesis|regulated exocytosis|regulation of keratinocyte differentiation|lung alveolus development|transmembrane transport|lipid homeostasis|regulation of insulin secretion involved in cellular response to glucose stimulus|establishment of skin barrier|protein localization to plasma membrane|epidermal lamellar body|epidermal lamellar body membrane|ATPase-coupled intramembrane lipid transporter activity|ABC-type transporter activity|positive regulation of protein localization to cell surface",null,null,"R-HSA-1369062,R-HSA-1643685,R-HSA-382551,R-HSA-382556,R-HSA-5619084,R-HSA-5619115,R-HSA-5682294","ABC transporters in lipid homeostasis|Disease|Transport of small molecules|ABC-family proteins mediated transport|ABC transporter disorders|Disorders of transmembrane transporters|Defective ABCA12 causes ARCI4B"]
["ABCA13",0.0246704071285973,0.0243681753184539,0.0106899051829278,0.0109201644349253,0.0445050154309716,0.0383142726647524,0.0168203105446649,0.0214003715111714,0.0104986899467492,0.00639712881168346,2.67704903544866E-3,0.00954633820869244,0.00270707751156083,0,0.00529461706734813,0.000899665132427994,0.00364909262444135,2.6338452501417E-3,8.7695832364473E-4,0.000912445642011819,0.00179116970107536,0.00631349687516273,0.00655714849265964,0.00927012012308585,1.88144726769755E-3,0.00360635756186834,1.83639229785939E-3,0.00267611967237104,154664,"ATP binding cassette subfamily A member 13","protein_coding","hsa02010","ABC transporters","GO:0005319,GO:0005524,GO:0005886,GO:0006869,GO:0016887,GO:0030667,GO:0032376,GO:0035577,GO:0035627,GO:0042626,GO:0043231,GO:0055085,GO:0097708,GO:0140359,GO:1900244","lipid transporter activity|ATP binding|plasma membrane|lipid transport|ATP hydrolysis activity|secretory granule membrane|positive regulation of cholesterol transport|azurophil granule membrane|ceramide transport|ATPase-coupled transmembrane transporter activity|intracellular membrane-bounded organelle|transmembrane transport|intracellular vesicle|ABC-type transporter activity|positive regulation of synaptic vesicle endocytosis",null,null,"R-HSA-168249,R-HSA-168256,R-HSA-6798695","Innate Immune System|Immune System|Neutrophil degranulation"]
["ABCA2",7.42926138990332,9.11851085479773,7.03272649369371,7.52335259519874,8.93021167854424,8.88355585828671,6.67415349234986,7.93727110927842,6.98660644268214,10.0080895382425,6.63287478912363,6.16560874931441,6.69184967068824,7.87469037660059,5.62690170771927,7.80691938431325,5.61753512258772,6.82900748558398,4.38662458671645,6.38292613154983,6.27416426390388,6.84592429298396,4.05148926091981,4.83667697402953,6.25588632251163,5.41303072055322,3.58202241480694,5.72473959324324,20,"ATP binding cassette subfamily A member 2","protein_coding","hsa02010,hsa04142","ABC transporters|Lysosome","GO:0000166,GO:0001573,GO:0005319,GO:0005524,GO:0005764,GO:0005765,GO:0005768,GO:0005815,GO:0005886,GO:0006629,GO:0006684,GO:0006687,GO:0006869,GO:0007626,GO:0009410,GO:0010008,GO:0016020,GO:0016887,GO:0019218,GO:0031410,GO:0032289,GO:0032383,GO:0032384,GO:0032805,GO:0042626,GO:0042632,GO:0042986,GO:0043190,GO:0043231,GO:0045540,GO:0045939,GO:0046512,GO:0048545,GO:0055085,GO:0060049,GO:0061135,GO:0070723,GO:0071072,GO:0090155,GO:0090156,GO:0090370,GO:0099038,GO:0099040,GO:0140359,GO:0150104,GO:1901873,GO:1902004,GO:1902993,GO:1904375,GO:1905598,GO:1905601,GO:2000008","nucleotide binding|ganglioside metabolic process|lipid transporter activity|ATP binding|lysosome|lysosomal membrane|endosome|microtubule organizing center|plasma membrane|lipid metabolic process|sphingomyelin metabolic process|glycosphingolipid metabolic process|lipid transport|locomotory behavior|response to xenobiotic stimulus|endosome membrane|membrane|ATP hydrolysis activity|regulation of steroid metabolic process|cytoplasmic vesicle|central nervous system myelin formation|regulation of intracellular cholesterol transport|negative regulation of intracellular cholesterol transport|positive regulation of low-density lipoprotein particle receptor catabolic process|ATPase-coupled transmembrane transporter activity|cholesterol homeostasis|positive regulation of amyloid precursor protein biosynthetic process|ATP-binding cassette (ABC) transporter complex|intracellular membrane-bounded organelle|regulation of cholesterol biosynthetic process|negative regulation of steroid metabolic process|sphingosine biosynthetic process|response to steroid hormone|transmembrane transport|regulation of protein glycosylation|endopeptidase regulator activity|response to cholesterol|negative regulation of phospholipid biosynthetic process|negative regulation of sphingolipid biosynthetic process|intracellular sphingolipid homeostasis|negative regulation of cholesterol efflux|ceramide floppase activity|ceramide translocation|ABC-type transporter activity|transport across blood-brain barrier|regulation of post-translational protein modification|positive regulation of amyloid-beta formation|positive regulation of amyloid precursor protein catabolic process|regulation of protein localization to cell periphery|negative regulation of low-density lipoprotein receptor activity|negative regulation of receptor-mediated endocytosis involved in cholesterol transport|regulation of protein localization to cell surface",null,null,"R-HSA-1369062,R-HSA-382551,R-HSA-382556","ABC transporters in lipid homeostasis|Transport of small molecules|ABC-family proteins mediated transport"]
["ABCA3",0.318476944615111,0.291273474629724,0.176331891241577,0.332849021403898,0.243376129664264,0.375749691316335,0.125711432537921,0.144137307228319,0.353200494505235,0.349991493586127,0.234231518172863,0.275227639888515,0.337815144767043,0.221882567265372,0.307573383761732,0.363905960956045,0.137395771465896,0.222895570683896,0.211323311863025,0.137421749248255,0.215811802644623,0.116432336127471,0.124956571111935,0.0957363862744911,0.17001677430906,0.170703291688321,0.130385661168304,0.176572283829642,21,"ATP binding cassette subfamily A member 3","protein_coding","hsa02010","ABC transporters","GO:0005319,GO:0005524,GO:0005615,GO:0005765,GO:0005770,GO:0005886,GO:0006855,GO:0006869,GO:0008559,GO:0009410,GO:0010875,GO:0015914,GO:0016887,GO:0019538,GO:0030324,GO:0030659,GO:0032464,GO:0032585,GO:0034204,GO:0042599,GO:0042626,GO:0042908,GO:0043129,GO:0043231,GO:0046470,GO:0046471,GO:0046618,GO:0046890,GO:0051384,GO:0055091,GO:0070925,GO:0097208,GO:0097232,GO:0097233,GO:0120009,GO:0120019,GO:0140345,GO:0150172,GO:1902995,GO:2001140","lipid transporter activity|ATP binding|extracellular space|lysosomal membrane|late endosome|plasma membrane|xenobiotic transmembrane transport|lipid transport|ABC-type xenobiotic transporter activity|response to xenobiotic stimulus|positive regulation of cholesterol efflux|phospholipid transport|ATP hydrolysis activity|protein metabolic process|lung development|cytoplasmic vesicle membrane|positive regulation of protein homooligomerization|multivesicular body membrane|lipid translocation|lamellar body|ATPase-coupled transmembrane transporter activity|xenobiotic transport|surfactant homeostasis|intracellular membrane-bounded organelle|phosphatidylcholine metabolic process|phosphatidylglycerol metabolic process|xenobiotic export from cell|regulation of lipid biosynthetic process|response to glucocorticoid|phospholipid homeostasis|organelle assembly|alveolar lamellar body|lamellar body membrane|alveolar lamellar body membrane|intermembrane lipid transfer|phosphatidylcholine transfer activity|phosphatidylcholine flippase activity|regulation of phosphatidylcholine metabolic process|positive regulation of phospholipid efflux|positive regulation of phospholipid transport",null,null,"R-HSA-1369062,R-HSA-1643685,R-HSA-382551,R-HSA-382556,R-HSA-392499,R-HSA-5619084,R-HSA-5619115,R-HSA-5668914,R-HSA-5683678,R-HSA-5683826,R-HSA-5687613,R-HSA-5688399","ABC transporters in lipid homeostasis|Disease|Transport of small molecules|ABC-family proteins mediated transport|Metabolism of proteins|ABC transporter disorders|Disorders of transmembrane transporters|Diseases of metabolism|Defective ABCA3 causes SMDP3|Surfactant metabolism|Diseases associated with surfactant metabolism|Defective ABCA3 causes SMDP3"]
["ABCA4",0.00367852282140326,6.99777103167918E-3,0.00345352888853027,0.0282233398318589,0.0143779906224808,0.0138172815595225,0.0137281142916394,0.010821444031129,0.0111002859280915,0.0106286668986538,0.00345943804803771,0,0.00699648517339262,0.00701404231348153,3.42100564652231E-3,0.00697559681963616,0.0247567380790898,6.80721522118591E-3,0.00679953848701504,0,0.0173599003950088,0.00349657152071308,0,0.0287505286655836,0.0182348647066115,0.0349525832338693,0.00355963897310914,0.0207494224269621,24,"ATP binding cassette subfamily A member 4","protein_coding","hsa02010","ABC transporters","GO:0001523,GO:0001750,GO:0003924,GO:0005501,GO:0005502,GO:0005503,GO:0005524,GO:0005548,GO:0005783,GO:0005886,GO:0006649,GO:0006869,GO:0007601,GO:0007603,GO:0016020,GO:0016887,GO:0031410,GO:0034632,GO:0034633,GO:0042574,GO:0042626,GO:0043231,GO:0045332,GO:0045494,GO:0055085,GO:0090555,GO:0097381,GO:0120202,GO:0140326,GO:0140327,GO:0140347,GO:0140359","retinoid metabolic process|photoreceptor outer segment|GTPase activity|retinoid binding|11-cis retinal binding|all-trans retinal binding|ATP binding|phospholipid transporter activity|endoplasmic reticulum|plasma membrane|phospholipid transfer to membrane|lipid transport|visual perception|phototransduction, visible light|membrane|ATP hydrolysis activity|cytoplasmic vesicle|retinol transmembrane transporter activity|retinol transport|retinal metabolic process|ATPase-coupled transmembrane transporter activity|intracellular membrane-bounded organelle|phospholipid translocation|photoreceptor cell maintenance|transmembrane transport|phosphatidylethanolamine flippase activity|photoreceptor disc membrane|rod photoreceptor disc membrane|ATPase-coupled intramembrane lipid transporter activity|flippase activity|N-retinylidene-phosphatidylethanolamine flippase activity|ABC-type transporter activity",null,null,"R-HSA-1643685,R-HSA-2187338,R-HSA-2187338,R-HSA-2453864,R-HSA-2453902,R-HSA-2453902,R-HSA-2474795,R-HSA-382551,R-HSA-382556,R-HSA-9675143,R-HSA-9709957,R-HSA-9709957","Disease|Visual phototransduction|Visual phototransduction|Retinoid cycle disease events|The canonical retinoid cycle in rods (twilight vision)|The canonical retinoid cycle in rods (twilight vision)|Diseases associated with visual transduction|Transport of small molecules|ABC-family proteins mediated transport|Diseases of the neuronal system|Sensory Perception|Sensory Perception"]
["ABCA5",1.24303647197948,1.39114059860573,1.4801718890976,1.36713798445176,1.59909411347444,1.37342171191372,1.46829696150401,1.41741116598193,0.888993391049777,0.480528906428121,0.498703515069253,0.668324144534989,1.03299644191362,0.831732630058009,0.848452818706395,1.0299123797634,0.608516395178251,0.564517210583923,0.453212432662588,0.688137358987028,0.656585032746452,0.552836248035138,0.681124901862479,0.685196100199677,0.635973451681884,0.660987174033018,0.615226088849547,0.501210656281923,23461,"ATP binding cassette subfamily A member 5","protein_coding","hsa02010","ABC transporters","GO:0000139,GO:0005319,GO:0005524,GO:0005764,GO:0005765,GO:0005770,GO:0005886,GO:0006869,GO:0008203,GO:0010745,GO:0010874,GO:0016887,GO:0031902,GO:0033344,GO:0034375,GO:0042626,GO:0042632,GO:0043691,GO:0055085,GO:0140359,GO:1903064","Golgi membrane|lipid transporter activity|ATP binding|lysosome|lysosomal membrane|late endosome|plasma membrane|lipid transport|cholesterol metabolic process|negative regulation of macrophage derived foam cell differentiation|regulation of cholesterol efflux|ATP hydrolysis activity|late endosome membrane|cholesterol efflux|high-density lipoprotein particle remodeling|ATPase-coupled transmembrane transporter activity|cholesterol homeostasis|reverse cholesterol transport|transmembrane transport|ABC-type transporter activity|positive regulation of reverse cholesterol transport",null,null,"R-HSA-1369062,R-HSA-382551,R-HSA-382556","ABC transporters in lipid homeostasis|Transport of small molecules|ABC-family proteins mediated transport"]
["ABCA6",0.193347918353986,0.200624671831553,0.158419153021282,0.134859568523645,0.326336135620313,0.135347372522021,0.147593341445325,0.110310612916172,0.162657502300839,0.145589265103174,0.0892632465352829,0.081346429446102,0.113666423703776,0.0469212721064617,0.173273846768247,0.116660215982021,0.250109655556006,0.143118415375418,0.116964831063019,0.243395945952242,0.355029432971436,0.223882720259992,0.336637548591789,0.250716008191216,0.317159182573669,0.116909735887099,0.268742529629702,0.171854719012529,23460,"ATP binding cassette subfamily A member 6","protein_coding","hsa02010","ABC transporters","GO:0000139,GO:0005319,GO:0005524,GO:0005654,GO:0005886,GO:0006869,GO:0016887,GO:0042626,GO:0043231,GO:0055085,GO:0140359","Golgi membrane|lipid transporter activity|ATP binding|nucleoplasm|plasma membrane|lipid transport|ATP hydrolysis activity|ATPase-coupled transmembrane transporter activity|intracellular membrane-bounded organelle|transmembrane transport|ABC-type transporter activity",null,null,"R-HSA-1369062,R-HSA-212436,R-HSA-382551,R-HSA-382556,R-HSA-73857,R-HSA-74160,R-HSA-9614085,R-HSA-9615017","ABC transporters in lipid homeostasis|Generic Transcription Pathway|Transport of small molecules|ABC-family proteins mediated transport|RNA Polymerase II Transcription|Gene expression (Transcription)|FOXO-mediated transcription|FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes"]
["ABCA7",1.08757064349684,1.48518917725492,0.871539318031818,1.49378736220159,1.36256943753864,1.49180450506794,1.00382187188653,1.36355600316621,1.57841160871979,2.09868081890975,1.1762169119825,1.41462674100589,1.61050620323276,1.85524855465918,1.09451674372446,1.95188054409046,0.993351630036839,1.18598560061099,0.563605319247612,0.851605239137224,0.79554169943901,1.21468677783075,0.533001284116663,0.736179242937877,1.21687400542177,0.941120967350686,0.477348612126493,0.803347475020442,10347,"ATP binding cassette subfamily A member 7","protein_coding","hsa02010","ABC transporters","GO:0000139,GO:0001891,GO:0005524,GO:0005548,GO:0005783,GO:0005794,GO:0005886,GO:0006909,GO:0007613,GO:0008542,GO:0009986,GO:0010875,GO:0016887,GO:0018149,GO:0019216,GO:0030054,GO:0031901,GO:0032587,GO:0033344,GO:0033700,GO:0034188,GO:0034205,GO:0034380,GO:0034504,GO:0038027,GO:0042626,GO:0042985,GO:0043231,GO:0043409,GO:0044857,GO:0045332,GO:0045806,GO:0050766,GO:0055085,GO:0070374,GO:0090554,GO:0090556,GO:0097386,GO:0140328,GO:0140359,GO:0150094,GO:1900223,GO:1901076,GO:1902430,GO:1902991,GO:1902995,GO:1903898,GO:2000010","Golgi membrane|phagocytic cup|ATP binding|phospholipid transporter activity|endoplasmic reticulum|Golgi apparatus|plasma membrane|phagocytosis|memory|visual learning|cell surface|positive regulation of cholesterol efflux|ATP hydrolysis activity|peptide cross-linking|regulation of lipid metabolic process|cell junction|early endosome membrane|ruffle membrane|cholesterol efflux|phospholipid efflux|apolipoprotein A-I receptor activity|amyloid-beta formation|high-density lipoprotein particle assembly|protein localization to nucleus|apolipoprotein A-I-mediated signaling pathway|ATPase-coupled transmembrane transporter activity|negative regulation of amyloid precursor protein biosynthetic process|intracellular membrane-bounded organelle|negative regulation of MAPK cascade|plasma membrane raft organization|phospholipid translocation|negative regulation of endocytosis|positive regulation of phagocytosis|transmembrane transport|positive regulation of ERK1 and ERK2 cascade|phosphatidylcholine floppase activity|phosphatidylserine floppase activity|glial cell projection|floppase activity|ABC-type transporter activity|amyloid-beta clearance by cellular catabolic process|positive regulation of amyloid-beta clearance|positive regulation of engulfment of apoptotic cell|negative regulation of amyloid-beta formation|regulation of amyloid precursor protein catabolic process|positive regulation of phospholipid efflux|negative regulation of PERK-mediated unfolded protein response|positive regulation of protein localization to cell surface",null,null,"R-HSA-1369062,R-HSA-382551,R-HSA-382556","ABC transporters in lipid homeostasis|Transport of small molecules|ABC-family proteins mediated transport"]
["ABCA8",2.55126774188921,1.75052735016188,1.31430101312782,1.20876806562838,2.80834420686517,1.94937901195819,1.13115575089383,1.53527128985497,3.5620142893931,2.0707667270363,1.90305024679395,2.38250515674994,3.9690683454574,2.74831534301734,2.60790328261949,3.3865851069266,2.05874990020091,1.81180954863629,1.41073097488239,1.89977604182056,2.2927628539947,1.75351506097739,1.76521674547499,2.22409363897526,1.95865281094426,1.2845993250399,1.47284856881336,1.29149292931578,10351,"ATP binding cassette subfamily A member 8","protein_coding","hsa02010","ABC transporters","GO:0005319,GO:0005524,GO:0005783,GO:0005886,GO:0006686,GO:0006869,GO:0008559,GO:0010874,GO:0010875,GO:0016323,GO:0016887,GO:0030301,GO:0033344,GO:0042626,GO:0042908,GO:0043231,GO:0055085,GO:0140359","lipid transporter activity|ATP binding|endoplasmic reticulum|plasma membrane|sphingomyelin biosynthetic process|lipid transport|ABC-type xenobiotic transporter activity|regulation of cholesterol efflux|positive regulation of cholesterol efflux|basolateral plasma membrane|ATP hydrolysis activity|cholesterol transport|cholesterol efflux|ATPase-coupled transmembrane transporter activity|xenobiotic transport|intracellular membrane-bounded organelle|transmembrane transport|ABC-type transporter activity",null,null,"R-HSA-382551,R-HSA-382556","Transport of small molecules|ABC-family proteins mediated transport"]
["ABCA9",0.0438550139402003,0.0451895105451386,0.013724218923617,0.0175247961537301,0.0857065471379116,0.0171592054074331,0.0136387773222795,0.0358367416215263,0.00735203319604615,3.51983328964819E-3,0.00687385087202287,0.0220608938859064,0.00347547745055729,0.00696839778649575,0.00679748627378403,0.0069302024802459,0.0105409848530119,0,0.00337764493172764,0.00702865190995492,0.00689877169710548,0.00347381725919,0.00360787944545955,0,0.0217394395721338,0,0,0,10350,"ATP binding cassette subfamily A member 9","protein_coding","hsa02010","ABC transporters","GO:0005319,GO:0005524,GO:0006869,GO:0016020,GO:0016887,GO:0042626,GO:0043231,GO:0055085,GO:0140359","lipid transporter activity|ATP binding|lipid transport|membrane|ATP hydrolysis activity|ATPase-coupled transmembrane transporter activity|intracellular membrane-bounded organelle|transmembrane transport|ABC-type transporter activity",null,null,"R-HSA-1369062,R-HSA-382551,R-HSA-382556","ABC transporters in lipid homeostasis|Transport of small molecules|ABC-family proteins mediated transport"]
["ABCA9-AS1",0,0,0,0,0,0,0,0,0,0,0,0,0.0490155290158902,0,0.0479333257700105,0.048869190721122197,0,0,0,0,0,0,0,0,0,0,0,0,104355297,"ABCA9 antisense RNA 1","non_coding"]
["ABCB1",2.53904696093341,2.38374865184347,2.22483162155163,2.14649009944667,2.80266737841178,1.89418951011904,1.88196570887835,2.40678881626718,4.18561906644184,3.2560416461985,3.33411382523623,3.82700776270942,3.91703586038235,2.37584319717356,2.70674883739855,3.10287395360443,2.00715943359859,1.64450351013792,1.16462941154742,1.87641589416086,1.59765588815855,1.55087005198213,1.62928890549242,1.85124719271635,1.87396775179347,1.32243552872121,1.51969326494178,1.29074702375356,5243,"ATP binding cassette subfamily B member 1","protein_coding","hsa02010,hsa04976,hsa05206,hsa05226","ABC transporters|Bile secretion|MicroRNAs in cancer|Gastric cancer","GO:0000086,GO:0005515,GO:0005524,GO:0005737,GO:0005886,GO:0006805,GO:0008559,GO:0009410,GO:0009986,GO:0015562,GO:0016020,GO:0016324,GO:0016887,GO:0022857,GO:0031625,GO:0042626,GO:0042910,GO:0045332,GO:0046865,GO:0046943,GO:0047484,GO:0055085,GO:0070062,GO:0070633,GO:0072089,GO:0090554,GO:0090555,GO:0098591,GO:0099038,GO:0099040,GO:0140115,GO:0140328,GO:0150104,GO:1901529,GO:1905039,GO:1990961,GO:1990962,GO:2001225","G2/M transition of mitotic cell cycle|protein binding|ATP binding|cytoplasm|plasma membrane|xenobiotic metabolic process|ABC-type xenobiotic transporter activity|response to xenobiotic stimulus|cell surface|efflux transmembrane transporter activity|membrane|apical plasma membrane|ATP hydrolysis activity|transmembrane transporter activity|ubiquitin protein ligase binding|ATPase-coupled transmembrane transporter activity|xenobiotic transmembrane transporter activity|phospholipid translocation|terpenoid transport|carboxylic acid transmembrane transporter activity|regulation of response to osmotic stress|transmembrane transport|extracellular exosome|transepithelial transport|stem cell proliferation|phosphatidylcholine floppase activity|phosphatidylethanolamine flippase activity|external side of apical plasma membrane|ceramide floppase activity|ceramide translocation|export across plasma membrane|floppase activity|transport across blood-brain barrier|positive regulation of anion channel activity|carboxylic acid transmembrane transport|xenobiotic detoxification by transmembrane export across the plasma membrane|xenobiotic transport across blood-brain barrier|regulation of chloride transport","WP3640,WP2876,WP5413,WP1604,WP299,WP2882,WP2328,WP4917,WP3672,WP5396,WP5176,WP2875,WP4673,WP2877,WP2289","Imatinib and chronic myeloid leukemia|Pregnane X receptor pathway|IL-24 Signaling pathway|Codeine and morphine metabolism|Nuclear receptors in lipid metabolism and toxicity|Nuclear receptors meta-pathway|Allograft rejection|Proximal tubule transport|lncRNA-mediated mechanisms of therapeutic resistance|Enterohepatic circulation of bile acids|Disorders of bile acid synthesis and biliary transport|Constitutive androstane receptor pathway|Male infertility|Vitamin D receptor pathway|Drug induction of bile acid pathway","R-HSA-2161517,R-HSA-2161522,R-HSA-382551,R-HSA-382556,R-HSA-9748784,R-HSA-9748784,R-HSA-9754706,R-HSA-9757110","Abacavir transmembrane transport|Abacavir ADME|Transport of small molecules|ABC-family proteins mediated transport|Drug ADME|Drug ADME|Atorvastatin ADME|Prednisone ADME"]
["ABCB10",4.07893508750938,3.8994631706436,2.50592996404579,2.36605032496208,4.15795676053373,3.21708608711151,2.34526131713275,2.67330378891365,3.2583035025738,2.68558204293625,1.98867735099717,2.93050336973578,3.72623572131028,2.28779962121594,2.64139259738283,3.18929490461417,2.68087314621475,2.62316385387859,2.32800718746042,3.50373635367648,3.25799235389426,2.86723974089658,3.4690915861225,3.55460679655596,3.07278611670407,2.61500429526954,3.33523319989187,1.91977172379166,23456,"ATP binding cassette subfamily B member 10","protein_coding","hsa02010","ABC transporters","GO:0005515,GO:0005524,GO:0005739,GO:0005743,GO:0006783,GO:0006839,GO:0016887,GO:0031966,GO:0034514,GO:0042803,GO:0045648,GO:0046985,GO:0048821,GO:0055085,GO:0070455,GO:0140359","protein binding|ATP binding|mitochondrion|mitochondrial inner membrane|heme biosynthetic process|mitochondrial transport|ATP hydrolysis activity|mitochondrial membrane|mitochondrial unfolded protein response|protein homodimerization activity|positive regulation of erythrocyte differentiation|positive regulation of hemoglobin biosynthetic process|erythrocyte development|transmembrane transport|positive regulation of heme biosynthetic process|ABC-type transporter activity",null,null,"R-HSA-1369007,R-HSA-382551,R-HSA-382556","Mitochondrial ABC transporters|Transport of small molecules|ABC-family proteins mediated transport"]
["ABCB11",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.00339155675047936,0,0,0,0,0,0,0,0,8647,"ATP binding cassette subfamily B member 11","protein_coding","hsa02010,hsa04976,hsa04979,hsa01522","ABC transporters|Bile secretion|Cholesterol metabolism|Endocrine resistance","GO:0000139,GO:0005515,GO:0005524,GO:0005768,GO:0005886,GO:0006631,GO:0006699,GO:0006805,GO:0006855,GO:0006979,GO:0008206,GO:0008559,GO:0009986,GO:0014070,GO:0015125,GO:0015126,GO:0015144,GO:0015432,GO:0015721,GO:0015722,GO:0016323,GO:0016324,GO:0016567,GO:0016887,GO:0031998,GO:0034219,GO:0038183,GO:0042632,GO:0043627,GO:0045471,GO:0046581,GO:0046618,GO:0046691,GO:0055037,GO:0055038,GO:0055085,GO:0055088,GO:0055091,GO:0070062,GO:0120189,GO:1904251","Golgi membrane|protein binding|ATP binding|endosome|plasma membrane|fatty acid metabolic process|bile acid biosynthetic process|xenobiotic metabolic process|xenobiotic transmembrane transport|response to oxidative stress|bile acid metabolic process|ABC-type xenobiotic transporter activity|cell surface|response to organic cyclic compound|bile acid transmembrane transporter activity|canalicular bile acid transmembrane transporter activity|carbohydrate transmembrane transporter activity|ABC-type bile acid transporter activity|bile acid and bile salt transport|canalicular bile acid transport|basolateral plasma membrane|apical plasma membrane|protein ubiquitination|ATP hydrolysis activity|regulation of fatty acid beta-oxidation|carbohydrate transmembrane transport|bile acid signaling pathway|cholesterol homeostasis|response to estrogen|response to ethanol|intercellular canaliculus|xenobiotic export from cell|intracellular canaliculus|recycling endosome|recycling endosome membrane|transmembrane transport|lipid homeostasis|phospholipid homeostasis|extracellular exosome|positive regulation of bile acid secretion|regulation of bile acid metabolic process","WP299,WP5238,WP2882,WP5304,WP5396,WP5329,WP5176,WP2879,WP4389,WP2289","Nuclear receptors in lipid metabolism and toxicity|Cholestasis|Nuclear receptors meta-pathway|Cholesterol metabolism|Enterohepatic circulation of bile acids|Cholesterol biosynthesis pathway in hepatocytes|Disorders of bile acid synthesis and biliary transport|Farnesoid X receptor pathway|Bile acids synthesis and enterohepatic circulation |Drug induction of bile acid pathway","R-HSA-1430728,R-HSA-159418,R-HSA-1643685,R-HSA-192105,R-HSA-193368,R-HSA-194068,R-HSA-556833,R-HSA-5619084,R-HSA-5619115,R-HSA-5678520,R-HSA-8957322","Metabolism|Recycling of bile acids and salts|Disease|Synthesis of bile acids and bile salts|Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol|Bile acid and bile salt metabolism|Metabolism of lipids|ABC transporter disorders|Disorders of transmembrane transporters|Defective ABCB11 causes PFIC2 and BRIC2|Metabolism of steroids"]
["ABCB4",1.06034063425344,0.816453225564247,0.641535254509918,0.713464038736537,1.22689792707337,0.802893106085105,0.606135332015573,0.752593054616461,1.4660953070553,1.34544836325483,1.21878663538559,1.22596273508752,1.4117243579935,1.15531997667016,1.01428545434313,1.32771879205957,0.718471842708587,0.7848766752931,0.42310654673246,0.806005918173642,0.581419657025883,0.566339794002251,0.61478121579624,0.736656902312576,0.770913972519515,0.524547139233245,0.589584318866736,0.680384823970348,5244,"ATP binding cassette subfamily B member 4","protein_coding","hsa02010,hsa04976","ABC transporters|Bile secretion","GO:0005515,GO:0005524,GO:0005548,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0005925,GO:0006629,GO:0016020,GO:0016324,GO:0016887,GO:0030136,GO:0032376,GO:0032782,GO:0042626,GO:0045121,GO:0045332,GO:0046581,GO:0055085,GO:0055088,GO:0061092,GO:0070062,GO:0090554,GO:0099038,GO:0099040,GO:0140359,GO:1901557,GO:1903413,GO:2001140","protein binding|ATP binding|phospholipid transporter activity|nucleoplasm|cytoplasm|cytosol|plasma membrane|focal adhesion|lipid metabolic process|membrane|apical plasma membrane|ATP hydrolysis activity|clathrin-coated vesicle|positive regulation of cholesterol transport|bile acid secretion|ATPase-coupled transmembrane transporter activity|membrane raft|phospholipid translocation|intercellular canaliculus|transmembrane transport|lipid homeostasis|positive regulation of phospholipid translocation|extracellular exosome|phosphatidylcholine floppase activity|ceramide floppase activity|ceramide translocation|ABC-type transporter activity|response to fenofibrate|cellular response to bile acid|positive regulation of phospholipid transport","WP299,WP5238,WP2882,WP5176,WP2879","Nuclear receptors in lipid metabolism and toxicity|Cholestasis|Nuclear receptors meta-pathway|Disorders of bile acid synthesis and biliary transport|Farnesoid X receptor pathway","R-HSA-1430728,R-HSA-1643685,R-HSA-1989781,R-HSA-382551,R-HSA-382556,R-HSA-400206,R-HSA-556833,R-HSA-5619084,R-HSA-5619115,R-HSA-5678771","Metabolism|Disease|PPARA activates gene expression|Transport of small molecules|ABC-family proteins mediated transport|Regulation of lipid metabolism by PPARalpha|Metabolism of lipids|ABC transporter disorders|Disorders of transmembrane transporters|Defective ABCB4 causes PFIC3, ICP3 and GBD1"]
["ABCB5",0,0.00331950194977635,0,0,0,0.0032772216231286,0,0,0,0,0,0.00351115901308575,0,0.0133088819454149,0,0,0,0.025832870606344,0,0,0,0,0,0,0,0,0,0,340273,"ATP binding cassette subfamily B member 5","protein_coding","hsa02010","ABC transporters","GO:0001654,GO:0005524,GO:0005886,GO:0008559,GO:0015562,GO:0016887,GO:0030154,GO:0042391,GO:0042626,GO:0042908,GO:0055085","eye development|ATP binding|plasma membrane|ABC-type xenobiotic transporter activity|efflux transmembrane transporter activity|ATP hydrolysis activity|cell differentiation|regulation of membrane potential|ATPase-coupled transmembrane transporter activity|xenobiotic transport|transmembrane transport",null,null,"R-HSA-382551,R-HSA-382556","Transport of small molecules|ABC-family proteins mediated transport"]
["ABCB6",9.97741792096414,11.0905183941052,11.6006677663002,11.9719998035759,9.77603005884082,10.6689444061104,9.54514865347738,10.5732722480151,8.29806716961094,11.3258313583149,11.0675642224303,10.2747305413009,7.58730782470601,9.07242365452998,7.85723719422358,7.78764992161389,8.87953698720446,11.1484093663779,9.18790147954665,10.6470207820639,8.64026243595708,9.81923641292717,6.90297269276697,9.50021663657724,8.85154110192206,10.0218298626667,7.75548338051013,9.92418415686556,10058,"ATP binding cassette subfamily B member 6 (Langereis blood group)","protein_coding","hsa02010","ABC transporters","GO:0000139,GO:0005524,GO:0005654,GO:0005739,GO:0005740,GO:0005741,GO:0005765,GO:0005768,GO:0005774,GO:0005783,GO:0005789,GO:0005794,GO:0005829,GO:0005886,GO:0006778,GO:0006779,GO:0006785,GO:0006878,GO:0006879,GO:0007420,GO:0015439,GO:0015562,GO:0015886,GO:0016887,GO:0020037,GO:0031901,GO:0032585,GO:0033013,GO:0033162,GO:0035351,GO:0036020,GO:0042168,GO:0043190,GO:0043588,GO:0046906,GO:0055085,GO:0070062,GO:0098849,GO:0140359,GO:1903232","Golgi membrane|ATP binding|nucleoplasm|mitochondrion|mitochondrial envelope|mitochondrial outer membrane|lysosomal membrane|endosome|vacuolar membrane|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|cytosol|plasma membrane|porphyrin-containing compound metabolic process|porphyrin-containing compound biosynthetic process|heme B biosynthetic process|intracellular copper ion homeostasis|intracellular iron ion homeostasis|brain development|ABC-type heme transporter activity|efflux transmembrane transporter activity|heme transport|ATP hydrolysis activity|heme binding|early endosome membrane|multivesicular body membrane|tetrapyrrole metabolic process|melanosome membrane|heme transmembrane transport|endolysosome membrane|heme metabolic process|ATP-binding cassette (ABC) transporter complex|skin development|tetrapyrrole binding|transmembrane transport|extracellular exosome|cellular detoxification of cadmium ion|ABC-type transporter activity|melanosome assembly",null,null,"R-HSA-1369007,R-HSA-1643685,R-HSA-382551,R-HSA-382556,R-HSA-5619084,R-HSA-5619115,R-HSA-5683371","Mitochondrial ABC transporters|Disease|Transport of small molecules|ABC-family proteins mediated transport|ABC transporter disorders|Disorders of transmembrane transporters|Defective ABCB6 causes MCOPCB7"]
["ABCB7",4.12409560617538,4.16821660410754,4.26288874952035,4.13528743747493,3.87511723233518,4.19225042889478,4.70158187668803,3.77945585796841,4.52003320894362,3.9663825509903,4.7060282915485,4.33214822357618,4.95965683772602,4.72601439084307,4.77922901738385,4.3997480124033,5.12131130086621,4.80377548744859,5.98032653865391,5.0489429985425,4.76738604707169,5.03535519515087,5.35709246582838,5.42184289613931,5.63580895862362,4.79377531548429,5.57464717646024,4.98566550092417,22,"ATP binding cassette subfamily B member 7","protein_coding","hsa02010","ABC transporters","GO:0005515,GO:0005524,GO:0005739,GO:0005743,GO:0006879,GO:0015232,GO:0015886,GO:0016226,GO:0016887,GO:0034755,GO:0042626,GO:0042803,GO:0055085,GO:0070455,GO:0140466,GO:0140481,GO:1903331,GO:1903427","protein binding|ATP binding|mitochondrion|mitochondrial inner membrane|intracellular iron ion homeostasis|heme transmembrane transporter activity|heme transport|iron-sulfur cluster assembly|ATP hydrolysis activity|iron ion transmembrane transport|ATPase-coupled transmembrane transporter activity|protein homodimerization activity|transmembrane transport|positive regulation of heme biosynthetic process|iron-sulfur cluster export from the mitochondrion|ABC-type iron-sulfur cluster transporter activity|positive regulation of iron-sulfur cluster assembly|negative regulation of reactive oxygen species biosynthetic process","WP5152","Iron-sulfur cluster biogenesis","R-HSA-1369007,R-HSA-1430728,R-HSA-2564830,R-HSA-382551,R-HSA-382556","Mitochondrial ABC transporters|Metabolism|Cytosolic iron-sulfur cluster assembly|Transport of small molecules|ABC-family proteins mediated transport"]
["ABCB8",5.14269838139968,6.74359747787758,7.47341597116174,8.42529352553592,6.17800905411193,6.29739265896752,7.62992668066726,7.13196077914766,5.84106620033916,8.82508275995583,8.10017974763004,7.18480554380533,5.83284795289093,8.06417870853044,7.15271738990268,6.55933137679062,7.06420511195182,8.2820858210271,8.64324627657084,7.94666821244265,6.70255169395942,8.36676451487534,7.09532761442227,6.719548883252,6.85868310994771,8.09154603818781,7.01031835768088,8.57114984531148,11194,"ATP binding cassette subfamily B member 8","protein_coding","hsa02010","ABC transporters","GO:0005515,GO:0005524,GO:0005654,GO:0005730,GO:0005739,GO:0005743,GO:0006884,GO:0015440,GO:0015833,GO:0016887,GO:0031966,GO:0043190,GO:0055085,GO:0062157,GO:0071805,GO:0140141","protein binding|ATP binding|nucleoplasm|nucleolus|mitochondrion|mitochondrial inner membrane|cell volume homeostasis|ABC-type peptide transporter activity|peptide transport|ATP hydrolysis activity|mitochondrial membrane|ATP-binding cassette (ABC) transporter complex|transmembrane transport|mitochondrial ATP-gated potassium channel complex|potassium ion transmembrane transport|mitochondrial potassium ion transmembrane transport",null,null,"R-HSA-1369007,R-HSA-382551,R-HSA-382556","Mitochondrial ABC transporters|Transport of small molecules|ABC-family proteins mediated transport"]
["ABCB9",2.02461702672302,2.21498928914386,1.82189668281842,2.12975827574891,2.03310805797834,2.11914480285195,1.9076149102489,1.96963881123036,1.71451553063822,2.1156742465638,1.51645496399824,1.9201917303762,1.65522902312009,1.75474951415085,1.51821356480747,1.58958703385105,1.87730188939676,2.15837525910017,2.1892232948972,1.56984423979765,2.06577712636959,1.79516068294296,1.61558453094719,1.75908682142698,1.91601359000545,1.85911840789047,1.93208136604971,1.85823495045075,23457,"ATP binding cassette subfamily B member 9","protein_coding","hsa02010,hsa04142","ABC transporters|Lysosome","GO:0002474,GO:0005515,GO:0005524,GO:0005764,GO:0005765,GO:0005769,GO:0005783,GO:0005789,GO:0006518,GO:0015031,GO:0015421,GO:0015440,GO:0015833,GO:0016020,GO:0016887,GO:0022857,GO:0035672,GO:0042626,GO:0042803,GO:0043231,GO:0055085","antigen processing and presentation of peptide antigen via MHC class I|protein binding|ATP binding|lysosome|lysosomal membrane|early endosome|endoplasmic reticulum|endoplasmic reticulum membrane|peptide metabolic process|protein transport|ABC-type oligopeptide transporter activity|ABC-type peptide transporter activity|peptide transport|membrane|ATP hydrolysis activity|transmembrane transporter activity|oligopeptide transmembrane transport|ATPase-coupled transmembrane transporter activity|protein homodimerization activity|intracellular membrane-bounded organelle|transmembrane transport",null,null,"R-HSA-382551,R-HSA-382556","Transport of small molecules|ABC-family proteins mediated transport"]
["ABCC1",21.2452157040247,23.631084759642,21.2652475121176,21.2098126335207,23.8553908875375,24.2448656785604,22.0070344476146,21.5658294300032,22.4169799684892,24.0428713617385,21.8995617250118,22.5939256539488,22.5200124069038,23.168498203475,22.8492147486819,23.2142474110292,16.7404448240756,19.6024062314872,14.3158177327474,17.7161194687714,16.5780928509519,17.4836369773002,12.5056725402125,15.2891107918003,17.7970186928606,16.0038670430097,10.865766051411,15.0234137220105,4363,"ATP binding cassette subfamily C member 1","protein_coding","hsa02010,hsa04071,hsa04977,hsa05206,hsa01523","ABC transporters|Sphingolipid signaling pathway|Vitamin digestion and absorption|MicroRNAs in cancer|Antifolate resistance","GO:0005524,GO:0005886,GO:0006691,GO:0006805,GO:0008559,GO:0009410,GO:0009925,GO:0015420,GO:0015431,GO:0015562,GO:0015889,GO:0016020,GO:0016323,GO:0016324,GO:0016328,GO:0016887,GO:0034040,GO:0034599,GO:0034634,GO:0034775,GO:0042167,GO:0042626,GO:0042908,GO:0042910,GO:0043225,GO:0045332,GO:0046943,GO:0050729,GO:0055085,GO:0060326,GO:0070062,GO:0070633,GO:0070729,GO:0071716,GO:0098656,GO:0099039,GO:0140115,GO:0140359,GO:0150104,GO:1904646,GO:1905039,GO:1990962","ATP binding|plasma membrane|leukotriene metabolic process|xenobiotic metabolic process|ABC-type xenobiotic transporter activity|response to xenobiotic stimulus|basal plasma membrane|ABC-type vitamin B12 transporter activity|ABC-type glutathione S-conjugate transporter activity|efflux transmembrane transporter activity|cobalamin transport|membrane|basolateral plasma membrane|apical plasma membrane|lateral plasma membrane|ATP hydrolysis activity|ATPase-coupled lipid transmembrane transporter activity|cellular response to oxidative stress|glutathione transmembrane transporter activity|glutathione transmembrane transport|heme catabolic process|ATPase-coupled transmembrane transporter activity|xenobiotic transport|xenobiotic transmembrane transporter activity|ATPase-coupled inorganic anion transmembrane transporter activity|phospholipid translocation|carboxylic acid transmembrane transporter activity|positive regulation of inflammatory response|transmembrane transport|cell chemotaxis|extracellular exosome|transepithelial transport|cyclic nucleotide transport|leukotriene transport|monoatomic anion transmembrane transport|sphingolipid translocation|export across plasma membrane|ABC-type transporter activity|transport across blood-brain barrier|cellular response to amyloid-beta|carboxylic acid transmembrane transport|xenobiotic transport across blood-brain barrier","WP5413,WP229,WP5300,WP5171","IL-24 Signaling pathway|Irinotecan pathway|TROP2 regulatory signaling|Leukotriene metabolic pathway","R-HSA-1430728,R-HSA-189445,R-HSA-189483,R-HSA-196741,R-HSA-196849,R-HSA-196854,R-HSA-2142691,R-HSA-2142753,R-HSA-2262752,R-HSA-382551,R-HSA-382556,R-HSA-556833,R-HSA-8953897,R-HSA-8978868,R-HSA-9707564,R-HSA-9711123,R-HSA-9748784,R-HSA-9753281,R-HSA-9758890","Metabolism|Metabolism of porphyrins|Heme degradation|Cobalamin (Cbl, vitamin B12) transport and metabolism|Metabolism of water-soluble vitamins and cofactors|Metabolism of vitamins and cofactors|Synthesis of Leukotrienes (LT) and Eoxins (EX)|Arachidonic acid metabolism|Cellular responses to stress|Transport of small molecules|ABC-family proteins mediated transport|Metabolism of lipids|Cellular responses to stimuli|Fatty acid metabolism|Cytoprotection by HMOX1|Cellular response to chemical stress|Drug ADME|Paracetamol ADME|Transport of RCbl within the body"]
["ABCC10",4.67108315710737,4.61264463638424,4.75926681247663,4.95328735165413,4.4225088324161,4.8694328672371,4.32324473869046,4.74316537441737,4.97387561172756,6.12099550749305,5.64910794078139,4.57011549364364,4.41059803524118,5.20475185659599,4.39809287328342,5.2863558923,3.84882751750088,4.6789558293857,3.80718905098617,4.7311632098002,3.74318136935862,3.78940965462262,3.18210303164118,3.81779411676353,4.39247751901547,3.92594644225982,3.28772594174499,4.07156164247328,89845,"ATP binding cassette subfamily C member 10","protein_coding","hsa02010","ABC transporters","GO:0005524,GO:0005765,GO:0005886,GO:0006691,GO:0006869,GO:0008559,GO:0009925,GO:0015431,GO:0016020,GO:0016323,GO:0016887,GO:0042626,GO:0042908,GO:0043225,GO:0055085,GO:0071716,GO:0098656,GO:0140359","ATP binding|lysosomal membrane|plasma membrane|leukotriene metabolic process|lipid transport|ABC-type xenobiotic transporter activity|basal plasma membrane|ABC-type glutathione S-conjugate transporter activity|membrane|basolateral plasma membrane|ATP hydrolysis activity|ATPase-coupled transmembrane transporter activity|xenobiotic transport|ATPase-coupled inorganic anion transmembrane transporter activity|transmembrane transport|leukotriene transport|monoatomic anion transmembrane transport|ABC-type transporter activity",null,null,"R-HSA-382551,R-HSA-382556","Transport of small molecules|ABC-family proteins mediated transport"]
["ABCC11",0.101061907356773,0.05455836399448,0.028207726886883,0.0261957435261756,0.0587182626455027,0.0307791182292577,0.0382256136117389,0.0482112930550897,0.0494535790542433,0.0973355702446517,0.0102749060760037,0.0604564017403623,0.0623409585781187,0.0885379810765301,0.0304822730299509,0.036256987988657,0.0210086274937185,0.0151636254354596,0.0201953665144781,0.0262657495631915,0.00773411795083342,0.0103851965158721,0.0431439356201595,0.0400275877865152,0.048743572687423,0.0103812961774362,0.0449331831709438,0.0308140171334032,85320,"ATP binding cassette subfamily C member 11","protein_coding","hsa02010","ABC transporters","GO:0005524,GO:0005774,GO:0005886,GO:0008514,GO:0008559,GO:0015216,GO:0015431,GO:0015432,GO:0015711,GO:0015721,GO:0015865,GO:0016020,GO:0016324,GO:0016887,GO:0030659,GO:0042626,GO:0042908,GO:0043225,GO:0055085,GO:0070062,GO:0071716,GO:0098656","ATP binding|vacuolar membrane|plasma membrane|organic anion transmembrane transporter activity|ABC-type xenobiotic transporter activity|purine nucleotide transmembrane transporter activity|ABC-type glutathione S-conjugate transporter activity|ABC-type bile acid transporter activity|organic anion transport|bile acid and bile salt transport|purine nucleotide transport|membrane|apical plasma membrane|ATP hydrolysis activity|cytoplasmic vesicle membrane|ATPase-coupled transmembrane transporter activity|xenobiotic transport|ATPase-coupled inorganic anion transmembrane transporter activity|transmembrane transport|extracellular exosome|leukotriene transport|monoatomic anion transmembrane transport",null,null,"R-HSA-382551,R-HSA-382556","Transport of small molecules|ABC-family proteins mediated transport"]
["ABCC12",0,0,0,0,0.00334354897440782,0,0,0,0,0,0,0,0,3.26217961876064E-3,0,0,0,0,0,0,0,0,0,0,0,0,0,0,94160,"ATP binding cassette subfamily C member 12","protein_coding","hsa02010","ABC transporters","GO:0005524,GO:0005783,GO:0005789,GO:0016020,GO:0016887,GO:0042626,GO:0055085,GO:0140359","ATP binding|endoplasmic reticulum|endoplasmic reticulum membrane|membrane|ATP hydrolysis activity|ATPase-coupled transmembrane transporter activity|transmembrane transport|ABC-type transporter activity"]
["ABCC2",0.0517464710398195,0.0351567709585527,0.0347010279653776,0.0425381806433283,0.0144469923600081,0.0173544904820001,0.0448304908775106,0.0217467549321578,0.122689133153928,0.0177994586209002,0.031284362833427,0.0632172312752316,0.0281202486497305,0.0176192589034665,0.0274993877720724,0.0350453678145439,0.0497510973929988,0.0410393032832993,0.0717377882003134,0.0568691473882655,0.0313977828287844,0.0281068159646625,0.0510851587900638,0.0469438222061935,0.0146579008441024,0.0175601624803095,0.0393439432804582,0.0243238350201894,1244,"ATP binding cassette subfamily C member 2","protein_coding","hsa02010,hsa04976,hsa01524,hsa01523","ABC transporters|Bile secretion|Platinum drug resistance|Antifolate resistance","GO:0005515,GO:0005524,GO:0005886,GO:0006805,GO:0006855,GO:0008514,GO:0008559,GO:0009986,GO:0010629,GO:0015127,GO:0015431,GO:0015721,GO:0015723,GO:0016324,GO:0016887,GO:0042167,GO:0042626,GO:0042910,GO:0043225,GO:0046581,GO:0046618,GO:0055085,GO:0070633,GO:0071716,GO:0098656,GO:0140359,GO:0150104,GO:1990962","protein binding|ATP binding|plasma membrane|xenobiotic metabolic process|xenobiotic transmembrane transport|organic anion transmembrane transporter activity|ABC-type xenobiotic transporter activity|cell surface|negative regulation of gene expression|bilirubin transmembrane transporter activity|ABC-type glutathione S-conjugate transporter activity|bile acid and bile salt transport|bilirubin transport|apical plasma membrane|ATP hydrolysis activity|heme catabolic process|ATPase-coupled transmembrane transporter activity|xenobiotic transmembrane transporter activity|ATPase-coupled inorganic anion transmembrane transporter activity|intercellular canaliculus|xenobiotic export from cell|transmembrane transport|transepithelial transport|leukotriene transport|monoatomic anion transmembrane transport|ABC-type transporter activity|transport across blood-brain barrier|xenobiotic transport across blood-brain barrier","WP2876,WP229,WP1604,WP299,WP5238,WP3612,WP2882,WP4917,WP5066,WP2884,WP5396,WP5176,WP2875,WP2289","Pregnane X receptor pathway|Irinotecan pathway|Codeine and morphine metabolism|Nuclear receptors in lipid metabolism and toxicity|Cholestasis|Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling|Nuclear receptors meta-pathway|Proximal tubule transport|FOXA2 pathway|NRF2 pathway|Enterohepatic circulation of bile acids|Disorders of bile acid synthesis and biliary transport|Constitutive androstane receptor pathway|Drug induction of bile acid pathway","R-HSA-1430728,R-HSA-1643685,R-HSA-189445,R-HSA-189483,R-HSA-382551,R-HSA-382556,R-HSA-5619084,R-HSA-5619115,R-HSA-5679001,R-HSA-9748784,R-HSA-9749641,R-HSA-9753281,R-HSA-9754706","Metabolism|Disease|Metabolism of porphyrins|Heme degradation|Transport of small molecules|ABC-family proteins mediated transport|ABC transporter disorders|Disorders of transmembrane transporters|Defective ABCC2 causes DJS|Drug ADME|Aspirin ADME|Paracetamol ADME|Atorvastatin ADME"]
["ABCC3",4.11921467720341,5.63828684918808,4.26883331870586,4.9226021958822,4.30679094890045,5.26522789571519,3.80415091760306,4.928297387075,1.24862326319659,2.07769967571964,1.49096409925197,1.31905729651862,1.28219822108314,1.47601193431986,0.998787320843788,1.40179899717018,1.7432803649286,1.97881214598061,0.842195199589329,1.7927887143514,1.95274028258393,1.83841263524918,0.734369611306234,1.20367425461948,1.72850666484196,1.98350303453035,0.845806565410388,1.79640325574634,8714,"ATP binding cassette subfamily C member 3","protein_coding","hsa02010,hsa04976,hsa01523","ABC transporters|Bile secretion|Antifolate resistance","GO:0005524,GO:0005886,GO:0006805,GO:0006855,GO:0008559,GO:0009925,GO:0015164,GO:0015431,GO:0015432,GO:0015721,GO:0015779,GO:0016020,GO:0016323,GO:0016887,GO:0042626,GO:0042908,GO:0042910,GO:0043225,GO:0055085,GO:0071714,GO:0071716,GO:0098656,GO:0140359,GO:0150104","ATP binding|plasma membrane|xenobiotic metabolic process|xenobiotic transmembrane transport|ABC-type xenobiotic transporter activity|basal plasma membrane|glucuronoside transmembrane transporter activity|ABC-type glutathione S-conjugate transporter activity|ABC-type bile acid transporter activity|bile acid and bile salt transport|glucuronoside transport|membrane|basolateral plasma membrane|ATP hydrolysis activity|ATPase-coupled transmembrane transporter activity|xenobiotic transport|xenobiotic transmembrane transporter activity|ATPase-coupled inorganic anion transmembrane transporter activity|transmembrane transport|icosanoid transmembrane transporter activity|leukotriene transport|monoatomic anion transmembrane transport|ABC-type transporter activity|transport across blood-brain barrier","WP2876,WP1604,WP299,WP5238,WP3612,WP2882,WP5066,WP2884,WP5396,WP1601,WP5176,WP2875,WP2289","Pregnane X receptor pathway|Codeine and morphine metabolism|Nuclear receptors in lipid metabolism and toxicity|Cholestasis|Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling|Nuclear receptors meta-pathway|FOXA2 pathway|NRF2 pathway|Enterohepatic circulation of bile acids|Fluoropyrimidine activity|Disorders of bile acid synthesis and biliary transport|Constitutive androstane receptor pathway|Drug induction of bile acid pathway","R-HSA-1430728,R-HSA-159418,R-HSA-194068,R-HSA-382551,R-HSA-382556,R-HSA-556833,R-HSA-8957322,R-HSA-9748784,R-HSA-9749641,R-HSA-9753281","Metabolism|Recycling of bile acids and salts|Bile acid and bile salt metabolism|Transport of small molecules|ABC-family proteins mediated transport|Metabolism of lipids|Metabolism of steroids|Drug ADME|Aspirin ADME|Paracetamol ADME"]
["ABCC4",25.5105492524777,24.867978738254,19.9777202071123,18.9888600953329,28.4261276619685,25.3036544819263,21.5997796035548,21.4548090107238,21.9459139431431,15.5064425760776,14.1760332497882,17.3300292285175,23.8031151300853,19.2859654692798,20.3857112027995,22.1059468981774,19.9801039109999,15.6413653068768,14.3128203835813,18.6723881418022,19.0128123541372,17.2612494470985,17.7860260668891,19.6733329149792,19.5316408236211,15.3336107285047,15.2333169493366,14.0845658696297,10257,"ATP binding cassette subfamily C member 4","protein_coding","hsa02010,hsa04024,hsa04976,hsa01523","ABC transporters|cAMP signaling pathway|Bile secretion|Antifolate resistance","GO:0001409,GO:0002576,GO:0005515,GO:0005524,GO:0005730,GO:0005794,GO:0005886,GO:0006805,GO:0006855,GO:0008559,GO:0015132,GO:0015143,GO:0015216,GO:0015431,GO:0015432,GO:0015562,GO:0015721,GO:0015732,GO:0015747,GO:0016020,GO:0016323,GO:0016324,GO:0016404,GO:0016887,GO:0031088,GO:0032310,GO:0034634,GO:0034775,GO:0042626,GO:0042910,GO:0043225,GO:0055085,GO:0060271,GO:0070730,GO:0071716,GO:0098591,GO:0098656,GO:0140115,GO:0140359,GO:0150104,GO:1903790","guanine nucleotide transmembrane transporter activity|platelet degranulation|protein binding|ATP binding|nucleolus|Golgi apparatus|plasma membrane|xenobiotic metabolic process|xenobiotic transmembrane transport|ABC-type xenobiotic transporter activity|prostaglandin transmembrane transporter activity|urate transmembrane transporter activity|purine nucleotide transmembrane transporter activity|ABC-type glutathione S-conjugate transporter activity|ABC-type bile acid transporter activity|efflux transmembrane transporter activity|bile acid and bile salt transport|prostaglandin transport|urate transport|membrane|basolateral plasma membrane|apical plasma membrane|15-hydroxyprostaglandin dehydrogenase (NAD+) activity|ATP hydrolysis activity|platelet dense granule membrane|prostaglandin secretion|glutathione transmembrane transporter activity|glutathione transmembrane transport|ATPase-coupled transmembrane transporter activity|xenobiotic transmembrane transporter activity|ATPase-coupled inorganic anion transmembrane transporter activity|transmembrane transport|cilium assembly|cAMP transport|leukotriene transport|external side of apical plasma membrane|monoatomic anion transmembrane transport|export across plasma membrane|ABC-type transporter activity|transport across blood-brain barrier|guanine nucleotide transmembrane transport","WP98,WP2876,WP5238,WP4707,WP3612,WP3945,WP2882,WP4917,WP2263,WP5066,WP2884,WP2858,WP5396,WP1601,WP5176,WP2289","Prostaglandin synthesis and regulation|Pregnane X receptor pathway|Cholestasis|Aspirin and miRNAs|Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling|TYROBP causal network in microglia|Nuclear receptors meta-pathway|Proximal tubule transport|Androgen receptor network in prostate cancer|FOXA2 pathway|NRF2 pathway|Ectoderm differentiation|Enterohepatic circulation of bile acids|Fluoropyrimidine activity|Disorders of bile acid synthesis and biliary transport|Drug induction of bile acid pathway","R-HSA-109582,R-HSA-114608,R-HSA-382551,R-HSA-382556,R-HSA-76002,R-HSA-76005,R-HSA-9748784,R-HSA-9748787,R-HSA-9753281","Hemostasis|Platelet degranulation |Transport of small molecules|ABC-family proteins mediated transport|Platelet activation, signaling and aggregation|Response to elevated platelet cytosolic Ca2+|Drug ADME|Azathioprine ADME|Paracetamol ADME"]
["ABCC5",2.9532397627689,3.24068247655996,2.67509960091122,2.99906376673809,3.41969529873494,2.81140652629216,2.36985036896464,2.71881613212215,3.73136714260749,3.853352750679,3.09160813261794,3.71173415551549,3.36032878983675,3.44840611111712,2.88508114289145,3.79343460222332,3.06077921179608,3.04380303904091,2.11803431205875,3.16123200964389,3.04740917388916,2.56679452384013,2.26240845728748,2.85876435195127,3.76957281433894,2.61731875805435,2.16738036014609,2.93133834463158,10057,"ATP binding cassette subfamily C member 5","protein_coding","hsa02010,hsa01523","ABC transporters|Antifolate resistance","GO:0005524,GO:0005796,GO:0005886,GO:0006805,GO:0006855,GO:0008514,GO:0008559,GO:0010008,GO:0015216,GO:0015232,GO:0015562,GO:0015865,GO:0016020,GO:0016323,GO:0016324,GO:0016887,GO:0022884,GO:0030213,GO:0034634,GO:0034775,GO:0035351,GO:0042626,GO:0042908,GO:0042910,GO:0043225,GO:0055085,GO:0070730,GO:0070731,GO:0098656,GO:0098838,GO:0140115,GO:0150104,GO:1901505","ATP binding|Golgi lumen|plasma membrane|xenobiotic metabolic process|xenobiotic transmembrane transport|organic anion transmembrane transporter activity|ABC-type xenobiotic transporter activity|endosome membrane|purine nucleotide transmembrane transporter activity|heme transmembrane transporter activity|efflux transmembrane transporter activity|purine nucleotide transport|membrane|basolateral plasma membrane|apical plasma membrane|ATP hydrolysis activity|macromolecule transmembrane transporter activity|hyaluronan biosynthetic process|glutathione transmembrane transporter activity|glutathione transmembrane transport|heme transmembrane transport|ATPase-coupled transmembrane transporter activity|xenobiotic transport|xenobiotic transmembrane transporter activity|ATPase-coupled inorganic anion transmembrane transporter activity|transmembrane transport|cAMP transport|cGMP transport|monoatomic anion transmembrane transport|folate transmembrane transport|export across plasma membrane|transport across blood-brain barrier|carbohydrate derivative transmembrane transporter activity","WP2882,WP2884,WP1601,WP5239","Nuclear receptors meta-pathway|NRF2 pathway|Fluoropyrimidine activity|Lac-Phe pathway","R-HSA-1430728,R-HSA-1630316,R-HSA-2142845,R-HSA-2142850,R-HSA-382551,R-HSA-382556,R-HSA-71387,R-HSA-9748784,R-HSA-9748787,R-HSA-9753281","Metabolism|Glycosaminoglycan metabolism|Hyaluronan metabolism|Hyaluronan biosynthesis and export|Transport of small molecules|ABC-family proteins mediated transport|Metabolism of carbohydrates|Drug ADME|Azathioprine ADME|Paracetamol ADME"]
["ABCC6",0.252045023237429,0.235741023927735,0.21296600023969,0.269927195287649,0.295545344408245,0.327411651054194,0.192043846615535,0.251273806735594,0.266199283294708,0.396494382695281,0.296292216176021,0.211315195707296,0.187759189456069,0.256313677161004,0.324253972004112,0.310670058637596,0.165589448616095,0.124377804309429,0.120355116021367,0.161581226391857,0.134806105757121,0.171697627000588,0.0705001121123678,0.24624108702828,0.195741909390441,0.151675800804678,0.166664548884633,0.169815230492583,368,"ATP binding cassette subfamily C member 6","protein_coding","hsa02010","ABC transporters","GO:0005524,GO:0005576,GO:0005654,GO:0005789,GO:0005886,GO:0007601,GO:0009410,GO:0009925,GO:0010467,GO:0015431,GO:0015867,GO:0016020,GO:0016323,GO:0016887,GO:0030505,GO:0030643,GO:0032026,GO:0042626,GO:0043225,GO:0046034,GO:0055062,GO:0055074,GO:0055085,GO:0071716,GO:0098656,GO:0140928,GO:1904383","ATP binding|extracellular region|nucleoplasm|endoplasmic reticulum membrane|plasma membrane|visual perception|response to xenobiotic stimulus|basal plasma membrane|gene expression|ABC-type glutathione S-conjugate transporter activity|ATP transport|membrane|basolateral plasma membrane|ATP hydrolysis activity|inorganic diphosphate transport|intracellular phosphate ion homeostasis|response to magnesium ion|ATPase-coupled transmembrane transporter activity|ATPase-coupled inorganic anion transmembrane transporter activity|ATP metabolic process|phosphate ion homeostasis|calcium ion homeostasis|transmembrane transport|leukotriene transport|monoatomic anion transmembrane transport|inhibition of non-skeletal tissue mineralization|response to sodium phosphate","WP3612,WP5322","Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling|CKAP4 signaling pathway map","R-HSA-1643685,R-HSA-382551,R-HSA-382556,R-HSA-5619084,R-HSA-5619115,R-HSA-5690338","Disease|Transport of small molecules|ABC-family proteins mediated transport|ABC transporter disorders|Disorders of transmembrane transporters|Defective ABCC6 causes PXE"]
["ABCC9",0.0114743919273143,0,0.0053862849196871,0.011004609677975,0.00560614639148342,0.00808127907322934,0,0.00562587647547894,0.00288542071161202,0.00552565506958499,0.0161865033623626,0.00577209582144819,0.0218240899651468,0,0.0213422406110167,0.0163191997959861,0,0.0291963394992739,0.00265121943348123,0.011034018620374,0.00541506225793871,2.72670810937378E-3,0.0311513149608179,0.0084076250689607,0.00568798929743745,0,0.0194312270687034,0.0161808840635073,10060,"ATP binding cassette subfamily C member 9","protein_coding","hsa02010","ABC transporters","GO:0001508,GO:0003007,GO:0005261,GO:0005267,GO:0005524,GO:0005886,GO:0008281,GO:0008282,GO:0009410,GO:0015272,GO:0015459,GO:0016020,GO:0016887,GO:0019829,GO:0022857,GO:0030017,GO:0031004,GO:0033198,GO:0042626,GO:0043225,GO:0044325,GO:0045776,GO:0048144,GO:0051607,GO:0055085,GO:0060976,GO:0061337,GO:0071805,GO:0086003,GO:0098655,GO:0098656,GO:0098662,GO:0140359,GO:0150104,GO:1990573","action potential|heart morphogenesis|monoatomic cation channel activity|potassium channel activity|ATP binding|plasma membrane|sulfonylurea receptor activity|inward rectifying potassium channel|response to xenobiotic stimulus|ATP-activated inward rectifier potassium channel activity|potassium channel regulator activity|membrane|ATP hydrolysis activity|ATPase-coupled monoatomic cation transmembrane transporter activity|transmembrane transporter activity|sarcomere|potassium ion-transporting ATPase complex|response to ATP|ATPase-coupled transmembrane transporter activity|ATPase-coupled inorganic anion transmembrane transporter activity|transmembrane transporter binding|negative regulation of blood pressure|fibroblast proliferation|defense response to virus|transmembrane transport|coronary vasculature development|cardiac conduction|potassium ion transmembrane transport|cardiac muscle cell contraction|monoatomic cation transmembrane transport|monoatomic anion transmembrane transport|inorganic cation transmembrane transport|ABC-type transporter activity|transport across blood-brain barrier|potassium ion import across plasma membrane",null,null,"R-HSA-112316,R-HSA-1296025,R-HSA-1296065,R-HSA-1296071,R-HSA-1643685,R-HSA-382551,R-HSA-382556,R-HSA-397014,R-HSA-5576891,R-HSA-5578775,R-HSA-5619084,R-HSA-5619115,R-HSA-5678420","Neuronal System|ATP sensitive Potassium channels|Inwardly rectifying K+ channels|Potassium Channels|Disease|Transport of small molecules|ABC-family proteins mediated transport|Muscle contraction|Cardiac conduction|Ion homeostasis|ABC transporter disorders|Disorders of transmembrane transporters|Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome"]
["ABCD1",6.64170579794488,7.95261107178047,7.75295303825251,8.1031524063451,6.81305925335111,7.80992371569783,7.53331861955015,7.72318605197071,6.00815607009152,8.25075784726709,7.37928967923405,5.16680685738211,5.49873010587882,6.85738963336817,5.56864007708862,6.18588853406008,6.62576409654903,7.59329736962795,6.93286800375252,6.51397604821163,6.52536181188564,7.24200668291783,4.6710130554846,6.3164966330754,6.03115690029985,7.16947692139861,4.50747119280304,7.81877899794171,215,"ATP binding cassette subfamily D member 1","protein_coding","hsa02010,hsa04146","ABC transporters|Peroxisome","GO:0000038,GO:0002082,GO:0005324,GO:0005515,GO:0005524,GO:0005737,GO:0005765,GO:0005777,GO:0005778,GO:0005789,GO:0005829,GO:0006635,GO:0007031,GO:0015607,GO:0015910,GO:0015916,GO:0015919,GO:0016020,GO:0016887,GO:0019899,GO:0030497,GO:0031966,GO:0031998,GO:0032000,GO:0036109,GO:0036113,GO:0042626,GO:0042758,GO:0042760,GO:0042802,GO:0042803,GO:0043217,GO:0043531,GO:0043651,GO:0046982,GO:0047617,GO:0048471,GO:0051900,GO:0055089,GO:0055092,GO:1900016,GO:1900407,GO:1903427,GO:1990535,GO:2001280","very long-chain fatty acid metabolic process|regulation of oxidative phosphorylation|long-chain fatty acid transporter activity|protein binding|ATP binding|cytoplasm|lysosomal membrane|peroxisome|peroxisomal membrane|endoplasmic reticulum membrane|cytosol|fatty acid beta-oxidation|peroxisome organization|ABC-type fatty-acyl-CoA transporter activity|long-chain fatty acid import into peroxisome|fatty-acyl-CoA transport|peroxisomal membrane transport|membrane|ATP hydrolysis activity|enzyme binding|fatty acid elongation|mitochondrial membrane|regulation of fatty acid beta-oxidation|positive regulation of fatty acid beta-oxidation|alpha-linolenic acid metabolic process|very long-chain fatty-acyl-CoA catabolic process|ATPase-coupled transmembrane transporter activity|long-chain fatty acid catabolic process|very long-chain fatty acid catabolic process|identical protein binding|protein homodimerization activity|myelin maintenance|ADP binding|linoleic acid metabolic process|protein heterodimerization activity|acyl-CoA hydrolase activity|perinuclear region of cytoplasm|regulation of mitochondrial depolarization|fatty acid homeostasis|sterol homeostasis|negative regulation of cytokine production involved in inflammatory response|regulation of cellular response to oxidative stress|negative regulation of reactive oxygen species biosynthetic process|neuron projection maintenance|positive regulation of unsaturated fatty acid biosynthetic process","WP5323,WP2877","Fatty Acids and Lipoproteins Transport in Hepatocytes|Vitamin D receptor pathway","R-HSA-1369062,R-HSA-1430728,R-HSA-1643685,R-HSA-2046104,R-HSA-2046105,R-HSA-2046106,R-HSA-382551,R-HSA-382556,R-HSA-390247,R-HSA-390918,R-HSA-556833,R-HSA-5619084,R-HSA-5619115,R-HSA-5684045,R-HSA-8978868,R-HSA-9603798,R-HSA-9609507","ABC transporters in lipid homeostasis|Metabolism|Disease|alpha-linolenic (omega3) and linoleic (omega6) acid metabolism|Linoleic acid (LA) metabolism|alpha-linolenic acid (ALA) metabolism|Transport of small molecules|ABC-family proteins mediated transport|Beta-oxidation of very long chain fatty acids|Peroxisomal lipid metabolism|Metabolism of lipids|ABC transporter disorders|Disorders of transmembrane transporters|Defective ABCD1 causes ALD|Fatty acid metabolism|Class I peroxisomal membrane protein import|Protein localization"]
["ABCD2",0.00278948778757625,0,0,0,0.0122659651980888,0.0026194711871522,0.00390385037237286,0.00547072605578472,2.80584658012295E-3,0.00402995141684354,0,0.00701614120584528,0.0026527781523579,0.00531887018918535,3.89131205738844E-3,0,0.00268192353618653,1.2905074026194E-3,0.00902336436668712,1.34121530728585E-3,0,0.0092802883389299,0.00413075781906809,0.0095383861853222,6.91390741294817E-3,0.0013252575668122,0.00134966804961679,0,225,"ATP binding cassette subfamily D member 2","protein_coding","hsa02010,hsa04146","ABC transporters|Peroxisome","GO:0000038,GO:0005324,GO:0005515,GO:0005524,GO:0005777,GO:0005778,GO:0005829,GO:0006635,GO:0007031,GO:0009617,GO:0015910,GO:0016887,GO:0032000,GO:0042626,GO:0042760,GO:0042803,GO:0043217,GO:0046982,GO:0047617,GO:0140359,GO:1900016,GO:1903427,GO:1990535,GO:2001280","very long-chain fatty acid metabolic process|long-chain fatty acid transporter activity|protein binding|ATP binding|peroxisome|peroxisomal membrane|cytosol|fatty acid beta-oxidation|peroxisome organization|response to bacterium|long-chain fatty acid import into peroxisome|ATP hydrolysis activity|positive regulation of fatty acid beta-oxidation|ATPase-coupled transmembrane transporter activity|very long-chain fatty acid catabolic process|protein homodimerization activity|myelin maintenance|protein heterodimerization activity|acyl-CoA hydrolase activity|ABC-type transporter activity|negative regulation of cytokine production involved in inflammatory response|negative regulation of reactive oxygen species biosynthetic process|neuron projection maintenance|positive regulation of unsaturated fatty acid biosynthetic process","WP5323,WP299","Fatty Acids and Lipoproteins Transport in Hepatocytes|Nuclear receptors in lipid metabolism and toxicity","R-HSA-1369062,R-HSA-382551,R-HSA-382556,R-HSA-9603798,R-HSA-9609507","ABC transporters in lipid homeostasis|Transport of small molecules|ABC-family proteins mediated transport|Class I peroxisomal membrane protein import|Protein localization"]
["ABCD3",11.5028139908134,9.56011343640707,7.78646066903478,7.00398125824591,9.80309082312057,8.30317052251211,7.11592329817729,7.05129228745345,9.5395196962371,5.93543808383175,6.31718017874941,7.55428377752533,10.4531564112916,6.38624823493783,8.78520576435893,8.1118676846585,8.74076852661544,8.04866496817235,8.64428502858324,10.6718657287125,9.46895486141222,8.80749347349259,12.8875522109204,10.7509165970997,8.61798421429582,8.34236557286991,10.6486756221615,7.36357958868031,5825,"ATP binding cassette subfamily D member 3","protein_coding","hsa02010,hsa04146","ABC transporters|Peroxisome","GO:0000038,GO:0005324,GO:0005515,GO:0005524,GO:0005739,GO:0005777,GO:0005778,GO:0005782,GO:0005829,GO:0006633,GO:0006635,GO:0006699,GO:0007031,GO:0009410,GO:0014070,GO:0015721,GO:0015910,GO:0016020,GO:0016887,GO:0042626,GO:0042760,GO:0042803,GO:0043231,GO:0043621,GO:0047617,GO:0140359,GO:1903512","very long-chain fatty acid metabolic process|long-chain fatty acid transporter activity|protein binding|ATP binding|mitochondrion|peroxisome|peroxisomal membrane|peroxisomal matrix|cytosol|fatty acid biosynthetic process|fatty acid beta-oxidation|bile acid biosynthetic process|peroxisome organization|response to xenobiotic stimulus|response to organic cyclic compound|bile acid and bile salt transport|long-chain fatty acid import into peroxisome|membrane|ATP hydrolysis activity|ATPase-coupled transmembrane transporter activity|very long-chain fatty acid catabolic process|protein homodimerization activity|intracellular membrane-bounded organelle|protein self-association|acyl-CoA hydrolase activity|ABC-type transporter activity|phytanic acid metabolic process","WP4549,WP5323,WP299,WP5329,WP5176","Fragile X syndrome|Fatty Acids and Lipoproteins Transport in Hepatocytes|Nuclear receptors in lipid metabolism and toxicity|Cholesterol biosynthesis pathway in hepatocytes|Disorders of bile acid synthesis and biliary transport","R-HSA-1369062,R-HSA-162582,R-HSA-194315,R-HSA-382551,R-HSA-382556,R-HSA-8980692,R-HSA-9012999,R-HSA-9013106,R-HSA-9603798,R-HSA-9609507,R-HSA-9716542","ABC transporters in lipid homeostasis|Signal Transduction|Signaling by Rho GTPases|Transport of small molecules|ABC-family proteins mediated transport|RHOA GTPase cycle|RHO GTPase cycle|RHOC GTPase cycle|Class I peroxisomal membrane protein import|Protein localization|Signaling by Rho GTPases, Miro GTPases and RHOBTB3"]
["ABCD4",5.56906515654647,7.28832436010457,7.66432812356863,6.6666321397137,6.05001702441223,7.73439632790681,7.5562834162063,6.57064669685498,7.5123273602893,8.18960403069152,8.71883779081719,8.15638764429552,6.40301539896063,8.13751732972886,6.70514644825254,7.30354817692084,6.83083632768036,7.43387908575791,7.47778786370001,7.95915690607727,7.08732847003938,7.47557974482256,6.53523169078627,6.8859197219467,6.81147378018242,7.8337385468231,6.99250996973905,7.96353085391942,5826,"ATP binding cassette subfamily D member 4","protein_coding","hsa02010,hsa04146","ABC transporters|Peroxisome","GO:0005324,GO:0005515,GO:0005524,GO:0005765,GO:0005777,GO:0005778,GO:0005789,GO:0006635,GO:0007031,GO:0009235,GO:0015420,GO:0015889,GO:0015910,GO:0016020,GO:0016887,GO:0042626,GO:0042760,GO:0042802,GO:0043190,GO:0055085,GO:1990830","long-chain fatty acid transporter activity|protein binding|ATP binding|lysosomal membrane|peroxisome|peroxisomal membrane|endoplasmic reticulum membrane|fatty acid beta-oxidation|peroxisome organization|cobalamin metabolic process|ABC-type vitamin B12 transporter activity|cobalamin transport|long-chain fatty acid import into peroxisome|membrane|ATP hydrolysis activity|ATPase-coupled transmembrane transporter activity|very long-chain fatty acid catabolic process|identical protein binding|ATP-binding cassette (ABC) transporter complex|transmembrane transport|cellular response to leukemia inhibitory factor","WP5323","Fatty Acids and Lipoproteins Transport in Hepatocytes","R-HSA-1430728,R-HSA-1643685,R-HSA-196741,R-HSA-196849,R-HSA-196854,R-HSA-3296469,R-HSA-3296482,R-HSA-5619084,R-HSA-5619115,R-HSA-5668914,R-HSA-5683329,R-HSA-9758881,R-HSA-9758890","Metabolism|Disease|Cobalamin (Cbl, vitamin B12) transport and metabolism|Metabolism of water-soluble vitamins and cofactors|Metabolism of vitamins and cofactors|Defects in cobalamin (B12) metabolism|Defects in vitamin and cofactor metabolism|ABC transporter disorders|Disorders of transmembrane transporters|Diseases of metabolism|Defective ABCD4 causes MAHCJ|Uptake of dietary cobalamins into enterocytes|Transport of RCbl within the body"]
["ABCE1",20.881184479886,16.8931341566364,16.2834979926858,14.6854888251736,18.7168516855937,15.6490258143452,16.0138965323261,15.090102340073,17.5507010142469,11.3547449409716,11.889487819708,15.2660099230662,18.7762262437893,11.9670713599792,16.265588960792,15.1891781286105,14.9686504673018,15.0791988527139,16.7350584105687,18.9594295902873,17.8956161131312,16.8621860235356,24.6878975960105,19.1062684864014,17.6081220389964,15.0569290174391,19.2332669348878,14.1085680887959,6059,"ATP binding cassette subfamily E member 1","protein_coding",null,null,"GO:0000054,GO:0003924,GO:0005506,GO:0005515,GO:0005524,GO:0005737,GO:0005739,GO:0005759,GO:0005829,GO:0006413,GO:0006415,GO:0006417,GO:0016020,GO:0016887,GO:0017111,GO:0022626,GO:0032790,GO:0043024,GO:0043273,GO:0051539,GO:0060698,GO:0060702,GO:0072344","ribosomal subunit export from nucleus|GTPase activity|iron ion binding|protein binding|ATP binding|cytoplasm|mitochondrion|mitochondrial matrix|cytosol|translational initiation|translational termination|regulation of translation|membrane|ATP hydrolysis activity|ribonucleoside triphosphate phosphatase activity|cytosolic ribosome|ribosome disassembly|ribosomal small subunit binding|CTPase activity|4 iron, 4 sulfur cluster binding|endoribonuclease inhibitor activity|negative regulation of endoribonuclease activity|rescue of stalled ribosome",null,null,"R-HSA-1169410,R-HSA-1280215,R-HSA-168256,R-HSA-8983711,R-HSA-909733,R-HSA-913531","Antiviral mechanism by IFN-stimulated genes|Cytokine Signaling in Immune system|Immune System|OAS antiviral response|Interferon alpha/beta signaling|Interferon Signaling"]
["ABCF1",28.4207966797423,32.1909798331307,28.8007067015288,32.936413786371,27.1604761052485,29.6622339706346,26.9742891207339,28.1022360776907,26.8435535969099,30.1635302797723,31.9546169082993,28.8326272616179,24.3477190889733,26.5976109994025,24.3255223095365,24.950585124087,24.9577335017523,26.6337123553791,25.8207851156996,27.0483663056169,26.1599963983132,26.4355840683108,21.5785478937998,24.8891595715702,25.7360743272359,26.5535339406876,21.5345173815527,25.7885156408544,23,"ATP binding cassette subfamily F member 1","protein_coding",null,null,"GO:0003723,GO:0005515,GO:0005524,GO:0005635,GO:0005654,GO:0005829,GO:0006412,GO:0006954,GO:0008135,GO:0016020,GO:0016887","RNA binding|protein binding|ATP binding|nuclear envelope|nucleoplasm|cytosol|translation|inflammatory response|translation factor activity, RNA binding|membrane|ATP hydrolysis activity","WP4754","IL-18 signaling pathway","R-HSA-382551,R-HSA-382556","Transport of small molecules|ABC-family proteins mediated transport"]
["ABCF1-DT",0.0496431219801899,0.141656536243494,0.0466067397700734,0.190442573009081,0.0970183381966292,0.0932348427883807,0,0,0,0.0478126894004513,0,0.149835316116432,0.0944203376622857,0.0473286391097538,0,0.282415323172894,0.0954577093625731,0.0459330323580574,0.045881232074444,0.143213636706705,0.187422983564825,0,0.0980173804409196,0.145499913025826,0.147652031569115,0.0943397900323368,0.0960774747511742,0.0933405571177276,107986587,null,"non_coding"]
["ABCF2",4.50758889619594,3.9816219662538,4.98099107320047,5.06543800014727,3.93332531093001,4.06510711000485,4.19998419902944,4.95731617990106,4.16267669688041,4.24389106580281,5.34230770118918,4.82256565821622,3.45992033214375,4.53018818802825,3.77116790506389,3.09390447038579,4.4883468487033,5.42137627243172,4.64479823500356,4.08264843337983,4.468063323403,4.61857011280957,3.68578477604328,3.71151733077013,3.97303665154156,5.04683491726337,3.73384190146312,4.82544082260506,10061,"ATP binding cassette subfamily F member 2","protein_coding","hsa05130","Pathogenic Escherichia coli infection","GO:0005524,GO:0016020,GO:0016887","ATP binding|membrane|ATP hydrolysis activity","WP3888","VEGFA-VEGFR2 signaling"]
["ABCF3",17.1513765123574,17.941587848069,17.3006800932469,19.5957291606484,16.4824322046883,16.3368635788717,15.6933292441537,18.3576631454489,16.8715417080078,19.4512284025726,19.3131726056808,18.2640368490995,14.1887835859838,16.2796241922458,13.7875815027211,14.8904989782571,16.5718233011589,16.9718607318922,16.402194466442,16.9204575945014,15.411957601783,16.2131422277197,15.0373479376437,14.1699869699308,14.8107779684796,16.7640582554866,16.3042901760048,17.90203787181,55324,"ATP binding cassette subfamily F member 3","protein_coding",null,null,"GO:0005515,GO:0005524,GO:0016020,GO:0016887,GO:0045296,GO:0051607","protein binding|ATP binding|membrane|ATP hydrolysis activity|cadherin binding|defense response to virus"]
["ABCG1",0,0,0,0,0,0.00220326049412876,2.18904216052602E-3,0,2.36002249343008E-3,0,0.00220652467717123,0,0,0.00894749796730659,0.00218201143508708,2.2246136954606E-3,0,0,0,0,0,0,0,0,0,0,0,0,9619,"ATP binding cassette subfamily G member 1","protein_coding","hsa02010,hsa05417","ABC transporters|Lipid and atherosclerosis","GO:0000139,GO:0005515,GO:0005524,GO:0005543,GO:0005739,GO:0005768,GO:0005789,GO:0005794,GO:0005886,GO:0008203,GO:0009897,GO:0010033,GO:0010745,GO:0010875,GO:0010887,GO:0015485,GO:0016887,GO:0019534,GO:0032367,GO:0033344,GO:0033700,GO:0033993,GO:0034041,GO:0034204,GO:0034374,GO:0034375,GO:0034436,GO:0042632,GO:0042803,GO:0042987,GO:0043531,GO:0043691,GO:0045542,GO:0046982,GO:0050714,GO:0055037,GO:0055085,GO:0055091,GO:0071403,GO:0090181,GO:0090554,GO:0120009,GO:0120020,GO:0140328,GO:1901998,GO:1902004","Golgi membrane|protein binding|ATP binding|phospholipid binding|mitochondrion|endosome|endoplasmic reticulum membrane|Golgi apparatus|plasma membrane|cholesterol metabolic process|external side of plasma membrane|response to organic substance|negative regulation of macrophage derived foam cell differentiation|positive regulation of cholesterol efflux|negative regulation of cholesterol storage|cholesterol binding|ATP hydrolysis activity|toxin transmembrane transporter activity|intracellular cholesterol transport|cholesterol efflux|phospholipid efflux|response to lipid|ABC-type sterol transporter activity|lipid translocation|low-density lipoprotein particle remodeling|high-density lipoprotein particle remodeling|glycoprotein transport|cholesterol homeostasis|protein homodimerization activity|amyloid precursor protein catabolic process|ADP binding|reverse cholesterol transport|positive regulation of cholesterol biosynthetic process|protein heterodimerization activity|positive regulation of protein secretion|recycling endosome|transmembrane transport|phospholipid homeostasis|cellular response to high density lipoprotein particle stimulus|regulation of cholesterol metabolic process|phosphatidylcholine floppase activity|intermembrane lipid transfer|cholesterol transfer activity|floppase activity|toxin transport|positive regulation of amyloid-beta formation","WP299,WP4718,WP5329","Nuclear receptors in lipid metabolism and toxicity|Cholesterol metabolism with Bloch and Kandutsch-Russell pathways|Cholesterol biosynthesis pathway in hepatocytes","R-HSA-1369062,R-HSA-162582,R-HSA-174824,R-HSA-382551,R-HSA-382556,R-HSA-8963899,R-HSA-8964058,R-HSA-9006931,R-HSA-9024446,R-HSA-9029569","ABC transporters in lipid homeostasis|Signal Transduction|Plasma lipoprotein assembly, remodeling, and clearance|Transport of small molecules|ABC-family proteins mediated transport|Plasma lipoprotein remodeling|HDL remodeling|Signaling by Nuclear Receptors|NR1H2 and NR1H3-mediated signaling|NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux"]
["ABCG2",0.839349394473912,0.936804555650598,0.801676189047224,0.67469834349667,0.801213268654615,0.779079810783794,1.03659617216395,0.932488013233876,0.761308595143059,0.663543057759395,0.63422532761462,0.683374173936358,0.673637106658629,0.513433956994635,0.699372759817477,0.676226107240927,0.751007858675686,0.453402680635879,1.00443232895586,0.569194299092418,0.906704223136636,0.668703570023198,1.33154388472629,0.900601513491391,0.79847965092254,0.686892493893653,1.16434278796725,0.729790101006855,9429,"ATP binding cassette subfamily G member 2 (Junior blood group)","protein_coding","hsa02010,hsa04976,hsa01523","ABC transporters|Bile secretion|Antifolate resistance","GO:0005515,GO:0005524,GO:0005654,GO:0005886,GO:0006869,GO:0008514,GO:0008559,GO:0015143,GO:0015225,GO:0015562,GO:0015711,GO:0015747,GO:0015878,GO:0016324,GO:0016887,GO:0031526,GO:0031966,GO:0032217,GO:0032218,GO:0042626,GO:0042802,GO:0042803,GO:0042910,GO:0045121,GO:0046415,GO:0055085,GO:0070633,GO:0097744,GO:0098591,GO:0140115,GO:0150104,GO:1990748,GO:1990962","protein binding|ATP binding|nucleoplasm|plasma membrane|lipid transport|organic anion transmembrane transporter activity|ABC-type xenobiotic transporter activity|urate transmembrane transporter activity|biotin transmembrane transporter activity|efflux transmembrane transporter activity|organic anion transport|urate transport|biotin transport|apical plasma membrane|ATP hydrolysis activity|brush border membrane|mitochondrial membrane|riboflavin transmembrane transporter activity|riboflavin transport|ATPase-coupled transmembrane transporter activity|identical protein binding|protein homodimerization activity|xenobiotic transmembrane transporter activity|membrane raft|urate metabolic process|transmembrane transport|transepithelial transport|renal urate salt excretion|external side of apical plasma membrane|export across plasma membrane|transport across blood-brain barrier|cellular detoxification|xenobiotic transport across blood-brain barrier","WP3640,WP5413,WP229,WP3612,WP4917,WP5322,WP1601","Imatinib and chronic myeloid leukemia|IL-24 Signaling pathway|Irinotecan pathway|Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling|Proximal tubule transport|CKAP4 signaling pathway map|Fluoropyrimidine activity","R-HSA-1430728,R-HSA-189445,R-HSA-189451,R-HSA-189483,R-HSA-2161517,R-HSA-2161522,R-HSA-382551,R-HSA-917937,R-HSA-9748784,R-HSA-9748784,R-HSA-9753281,R-HSA-9793528","Metabolism|Metabolism of porphyrins|Heme biosynthesis|Heme degradation|Abacavir transmembrane transport|Abacavir ADME|Transport of small molecules|Iron uptake and transport|Drug ADME|Drug ADME|Paracetamol ADME|Ciprofloxacin ADME"]
["ABCG4",0.285188082718022,0.220399711118102,0.122716357349194,0.096868822539499,0.197393934294266,0.245488964502974,0.210645008712094,0.273828408450909,0.370528213020746,0.469232490245646,0.374366553906406,0.334743390821283,0.259910865564092,0.31154282720141,0.243121378139625,0.360535497425039,0.194218672057728,0.219895407277277,0.148262010897823,0.18282860564365,0.173842356311808,0.180721189182529,0.0762513432369904,0.226379520839609,0.206166105353834,0.18629873237706,0.0977398247110523,0.296037898753701,64137,"ATP binding cassette subfamily G member 4","protein_coding","hsa02010","ABC transporters","GO:0005515,GO:0005524,GO:0005886,GO:0006355,GO:0010008,GO:0010875,GO:0016887,GO:0031410,GO:0033344,GO:0034041,GO:0042632,GO:0042802,GO:0042803,GO:0045542,GO:0046982,GO:0055085,GO:0071403,GO:1990830","protein binding|ATP binding|plasma membrane|regulation of DNA-templated transcription|endosome membrane|positive regulation of cholesterol efflux|ATP hydrolysis activity|cytoplasmic vesicle|cholesterol efflux|ABC-type sterol transporter activity|cholesterol homeostasis|identical protein binding|protein homodimerization activity|positive regulation of cholesterol biosynthetic process|protein heterodimerization activity|transmembrane transport|cellular response to high density lipoprotein particle stimulus|cellular response to leukemia inhibitory factor",null,null,"R-HSA-1369062,R-HSA-382551,R-HSA-382556","ABC transporters in lipid homeostasis|Transport of small molecules|ABC-family proteins mediated transport"]
["ABHD1",0.136903073820432,0.117195783413231,0.0514118023263583,0.223206626643833,0.173908697138142,0.128558963011911,0.255458663100898,0.41616485486093,0.289182461639097,0.145040728181257,0.115874483567386,0.468301947882442,0.117174248388925,0.195780480217849,0.127319092827402,0.207687855741163,0.0921368088591011,0.114004433282796,0.0759172443364849,0.131648899156494,0.0646081006067166,0.182183984486031,0.351399029219122,0.160500665866985,0.176447552200166,0.0390247633221627,0.0927350130851227,0.231668513272897,84696,"abhydrolase domain containing 1","protein_coding",null,null,"GO:0003674,GO:0005515,GO:0008126,GO:0008150,GO:0016020,GO:0047372,GO:0051792,GO:0051793","molecular_function|protein binding|acetylesterase activity|biological_process|membrane|acylglycerol lipase activity|medium-chain fatty acid biosynthetic process|medium-chain fatty acid catabolic process"]
["ABHD10",10.3174460851845,9.68913781060246,8.4389699431549,8.34078734245299,9.26539620941095,8.62995004218163,9.22225806026974,8.68603396028129,8.3631107172207,5.98160311520635,7.30798666033148,7.80794182201804,9.00771079031637,7.78276877919329,8.89308174340169,7.75919754497029,11.2744715560524,8.67089755304924,13.2661179452648,10.1441031813374,11.058725878278,9.89322400721216,14.5082559495803,13.4922645263366,11.2468614502199,10.5685752644235,13.1107006331569,10.8540812405937,55347,"abhydrolase domain containing 10%2C depalmitoylase","protein_coding",null,null,"GO:0002084,GO:0004553,GO:0005739,GO:0005759,GO:0005829,GO:0008474,GO:0019391,GO:0052695,GO:0102390","protein depalmitoylation|hydrolase activity, hydrolyzing O-glycosyl compounds|mitochondrion|mitochondrial matrix|cytosol|palmitoyl-(protein) hydrolase activity|glucuronoside catabolic process|cellular glucuronidation|mycophenolic acid acyl-glucuronide esterase activity",null,null,"R-HSA-1430728,R-HSA-156580,R-HSA-156588,R-HSA-211859","Metabolism|Phase II - Conjugation of compounds|Glucuronidation|Biological oxidations"]
["ABHD11",6.04101048108304,5.48538538845695,5.79401182759239,7.57057621878973,4.16908837089344,5.28074297248139,5.46578292189994,5.88541291636854,3.32038601260193,5.26534349192763,4.12287320299266,5.47392069434656,3.51149052958029,3.22176080274852,3.14274177581235,3.24121477625967,5.15575589825109,6.26559021299645,6.69264157992005,5.38257293157744,5.8742272986579,5.39494245166828,4.72725111124077,4.60169884657334,3.94536805555324,5.6036739366836,5.39124379798693,6.08403329317602,83451,"abhydrolase domain containing 11","protein_coding",null,null,"GO:0003674,GO:0005575,GO:0005739,GO:0008150,GO:0044255,GO:0052689","molecular_function|cellular_component|mitochondrion|biological_process|cellular lipid metabolic process|carboxylic ester hydrolase activity","WP4932","7q11.23 copy number variation syndrome"]
["ABHD11-AS1",1.59571675811164,1.13834353966495,1.81914086603614,2.35023448054388,1.94908405647668,2.72933668217614,2.87123655527126,1.95594359767721,0.0573240981543725,0.109777126192156,0.214382765463174,0.114673117196931,0.325181247466941,0.380330142190643,0.159000820577476,0.108070134237407,1.26022339559109,1.21280685226169,0.790068996292488,1.69888311957997,1.61370000120031,1.84181350428901,1.01270811461897,1.11355113140273,1.07352079612301,1.29961537389155,0.661776771119081,2.46454591510211,171022,"ABHD11 antisense RNA 1 (tail to tail)","non_coding"]
["ABHD12",40.3210614443132,35.8303300465999,32.8374726016432,40.2875395222271,39.9903067805282,35.1060957811248,33.1809676051975,39.2672178958732,36.5321499815007,40.3211418670342,37.9906377551005,37.3419640113093,33.9009125422952,35.2097676511351,29.0015418291218,31.946244748379,36.2415309794833,39.1474239728149,32.8070515557069,33.8845336521748,34.295737271075,37.0427200442214,27.3654276007472,30.2288409406485,36.5316768751731,37.7781531084721,28.1958681772921,37.8039278888952,26090,"abhydrolase domain containing 12%2C lysophospholipase","protein_coding",null,null,"GO:0004620,GO:0004622,GO:0005789,GO:0005886,GO:0006660,GO:0007628,GO:0008474,GO:0009395,GO:0010996,GO:0016020,GO:0019369,GO:0032281,GO:0032839,GO:0046464,GO:0046475,GO:0047372,GO:0050727,GO:0052651,GO:0098734","phospholipase activity|lysophospholipase activity|endoplasmic reticulum membrane|plasma membrane|phosphatidylserine catabolic process|adult walking behavior|palmitoyl-(protein) hydrolase activity|phospholipid catabolic process|response to auditory stimulus|membrane|arachidonic acid metabolic process|AMPA glutamate receptor complex|dendrite cytoplasm|acylglycerol catabolic process|glycerophospholipid catabolic process|acylglycerol lipase activity|regulation of inflammatory response|monoacylglycerol catabolic process|macromolecule depalmitoylation",null,null,"R-HSA-109582,R-HSA-114508,R-HSA-162582,R-HSA-372790,R-HSA-388396,R-HSA-416476,R-HSA-426048,R-HSA-76002","Hemostasis|Effects of PIP2 hydrolysis|Signal Transduction|Signaling by GPCR|GPCR downstream signalling|G alpha (q) signalling events|Arachidonate production from DAG|Platelet activation, signaling and aggregation"]
["ABHD12B",0.829583561972811,0.49941240864964,1.0844645759511,0.815761169522635,0.708022219948015,0.66068890056176,1.08751051711471,0.545757137850411,0.316879218079682,0.252846614184311,0.118507652587551,0.242993541485278,0.259646732979382,0.240275350556413,0.283211823900954,0.248914946894691,1.00961309279075,1.02020718344162,1.19375208765876,1.17137262029372,1.00105557924091,1.02810916972727,1.21292212637165,0.964369115785512,1.13479818107794,1.27717038691226,1.2498867279229,0.987220929390847,145447,"abhydrolase domain containing 12B","protein_coding",null,null,"GO:0004622,GO:0005789,GO:0006660,GO:0047372,GO:0052651","lysophospholipase activity|endoplasmic reticulum membrane|phosphatidylserine catabolic process|acylglycerol lipase activity|monoacylglycerol catabolic process"]
["ABHD13",2.53417339294374,1.9749394654436,2.20573062003317,1.58304679477635,2.41349738893574,1.91584266791702,1.66741774361086,1.72099224239519,2.31877343520686,1.29192565182429,1.55231871105249,1.78188390460813,2.58184479328217,1.70385216199126,2.43893645465557,2.22761818341492,2.11983100156053,1.95088784259136,2.56484426852628,2.2090575440284,2.41841827653071,2.07670509542003,4.00444516948849,2.98196782417054,2.4208597690879,1.99578833667262,3.01579062730578,1.8122975869461,84945,"abhydrolase domain containing 13","protein_coding",null,null,"GO:0008474,GO:0016020,GO:0032839,GO:0098734","palmitoyl-(protein) hydrolase activity|membrane|dendrite cytoplasm|macromolecule depalmitoylation"]
["ABHD14A",4.27354631778244,4.59400385973157,4.89055975347174,4.97164986268899,4.595993490236,4.5829823120917,5.49711815578991,5.45525303603032,3.38292841537844,6.40533054464264,5.87395705249252,4.32498374943962,4.18434443855913,5.44847648618271,5.00912247415891,4.55547043335639,3.81700993474142,4.79646857123561,5.56230313875113,3.55024724541408,4.36773791131639,4.35060091443261,4.19396693871597,4.22454766234742,3.93604857514029,4.44507673907054,3.98861220110304,5.2062753427621,25864,"ABHD14A-ACY1 readthrough","protein_coding",null,null,"GO:0005737,GO:0016020,GO:0016787","cytoplasm|membrane|hydrolase activity"]
["ABHD14B",15.2644961118734,20.0636691200485,23.3551402767304,22.9671047001037,16.7857052146317,21.8232084019746,25.8413471798267,24.9038090700069,17.345585247321,22.3507940675608,22.0947962749393,19.2745888058977,16.2625761633279,23.8856202699592,21.448147210725,22.4856832112773,18.3873992740918,22.27041492706,23.5129547549336,19.911925708907,17.7378319089674,21.2069516213932,18.4108977757285,17.3336548007016,17.3487804774573,19.0969555558872,20.6903452956201,22.2639060534379,84836,"abhydrolase domain containing 14B","protein_coding",null,null,"GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0016787,GO:0045944,GO:0050427,GO:0061733,GO:0070062","protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|hydrolase activity|positive regulation of transcription by RNA polymerase II|3'-phosphoadenosine 5'-phosphosulfate metabolic process|peptide-lysine-N-acetyltransferase activity|extracellular exosome",null,null,"R-HSA-1430728,R-HSA-156580,R-HSA-156584,R-HSA-211859","Metabolism|Phase II - Conjugation of compounds|Cytosolic sulfonation of small molecules|Biological oxidations"]
["ABHD15",5.46534948068503,5.4848096494485,5.00786215617083,5.26379835977484,4.75969133323678,4.68280808757483,4.53735406381402,4.82186026774458,3.84352168424227,4.51291816697541,3.7024308786284,4.07734848624399,3.47234036438198,3.5178515451011,4.13511412415926,3.93772040949743,4.30461783886723,4.66405746863907,3.99529354215262,4.20150751032508,4.8961839211677,4.62268383315717,3.94755736914937,3.71049778200913,4.10977506083141,4.334889037607,3.56316191477325,4.33977457959991,116236,"abhydrolase domain containing 15","protein_coding",null,null,"GO:0005515,GO:0005576,GO:0016020,GO:0016042,GO:0034338,GO:0044255,GO:0047372,GO:0060612","protein binding|extracellular region|membrane|lipid catabolic process|short-chain carboxylesterase activity|cellular lipid metabolic process|acylglycerol lipase activity|adipose tissue development"]
["ABHD16A",12.3761969259915,12.7978512692272,11.2380802088617,12.9596621635843,12.4561902855434,11.7852612401218,13.1485090531301,12.9663622662836,12.9271267887849,15.1260503986138,14.1370858746826,13.3383733666592,13.3911522004419,12.4073941751553,13.721141380574,13.2631908851373,15.1775909522927,15.9373194092433,11.7706682013909,14.7119967356808,13.1264033359256,13.109122068589,11.8859570153694,13.1110823090058,13.6499982902451,14.1512120671311,12.7506880691291,14.2521270927298,7920,"abhydrolase domain containing 16A%2C phospholipase","protein_coding","hsa00561","Glycerolipid metabolism","GO:0004620,GO:0004622,GO:0005515,GO:0006660,GO:0016020,GO:0047372,GO:0052651,GO:1905344","phospholipase activity|lysophospholipase activity|protein binding|phosphatidylserine catabolic process|membrane|acylglycerol lipase activity|monoacylglycerol catabolic process|prostaglandin catabolic process","WP4754","IL-18 signaling pathway"]
["ABHD16B",0.361585717441222,0.18916040486975,0.186708287489368,0.208069048579338,0.300327390976889,0.237683190770379,0.151810294058049,0.124099439530694,0.309150283876129,0.348253391608921,0.0510075694487331,0.236460428452023,0.154739165042116,0.258545785076422,0.033627269453676,0.20570291144585,0.104292829343817,0.133825011779612,0.100255569482588,0.0173854247108744,0.0511924950078974,0.120295192975518,0.160634117442915,0.158966705780731,0.215090685827041,0.10307144061883,0.227434907534721,0.220956067301824,140701,"abhydrolase domain containing 16B","protein_coding",null,null,"GO:0004620,GO:0005654,GO:0006660,GO:0047372,GO:0052651","phospholipase activity|nucleoplasm|phosphatidylserine catabolic process|acylglycerol lipase activity|monoacylglycerol catabolic process"]
["ABHD17A",12.2300418694669,12.4814211512216,13.6137004273091,14.7818299190028,11.5000826088255,11.9411937813023,12.0792498331049,12.6071231480842,11.8681774818149,16.7031470047936,15.3858101934344,12.3346950842253,11.7259946673975,13.6190843165302,10.9962953146208,12.3468219354941,14.1438665581702,14.8221402898993,18.664285575896,14.7538539409855,17.7975687265146,15.4842594528268,14.8893011971432,14.18629562932,14.5253303789607,16.8595975451802,16.1079210162901,18.2595946211731,81926,"abhydrolase domain containing 17A%2C depalmitoylase","protein_coding",null,null,"GO:0002084,GO:0005515,GO:0005886,GO:0008474,GO:0010008,GO:0016020,GO:0016607,GO:0043197,GO:0043231,GO:0055038,GO:0072657,GO:0098839,GO:0098944,GO:0098978,GO:0099175,GO:1902817,GO:1905668","protein depalmitoylation|protein binding|plasma membrane|palmitoyl-(protein) hydrolase activity|endosome membrane|membrane|nuclear speck|dendritic spine|intracellular membrane-bounded organelle|recycling endosome membrane|protein localization to membrane|postsynaptic density membrane|postsynaptic recycling endosome membrane|glutamatergic synapse|regulation of postsynapse organization|negative regulation of protein localization to microtubule|positive regulation of protein localization to endosome",null,null,"R-HSA-162582,R-HSA-5673001,R-HSA-5683057,R-HSA-5684996,R-HSA-9648002","Signal Transduction|RAF/MAP kinase cascade|MAPK family signaling cascades|MAPK1/MAPK3 signaling|RAS processing"]
["ABHD17B",2.26457941833068,1.67668598053935,2.04754864836654,1.24635346438389,2.200278660414,1.97552170887203,1.68066193485426,1.64024509814077,3.01557591097624,1.73495019008224,1.91794547949366,2.74438221957983,2.73482085653074,2.62514678846377,2.7043547681927,3.09264999541849,1.79376199204348,1.95247178880655,2.04540503619321,2.46224915538846,2.19207729757325,1.98133934549558,2.6167131602292,2.30042654852241,2.25791319111205,2.20677430328267,2.76414206953581,2.06243646510618,51104,"abhydrolase domain containing 17B%2C depalmitoylase","protein_coding",null,null,"GO:0002084,GO:0005886,GO:0006508,GO:0008236,GO:0008474,GO:0010008,GO:0016020,GO:0043197,GO:0055038,GO:0098839,GO:0099175,GO:1902473,GO:1902817,GO:1902950,GO:1905668","protein depalmitoylation|plasma membrane|proteolysis|serine-type peptidase activity|palmitoyl-(protein) hydrolase activity|endosome membrane|membrane|dendritic spine|recycling endosome membrane|postsynaptic density membrane|regulation of postsynapse organization|regulation of protein localization to synapse|negative regulation of protein localization to microtubule|regulation of dendritic spine maintenance|positive regulation of protein localization to endosome",null,null,"R-HSA-162582,R-HSA-5673001,R-HSA-5683057,R-HSA-5684996,R-HSA-9648002","Signal Transduction|RAF/MAP kinase cascade|MAPK family signaling cascades|MAPK1/MAPK3 signaling|RAS processing"]
["ABHD17C",10.9149266263839,11.9131287026258,10.0115067154891,10.7746454965722,8.98097647200754,10.5391505295025,10.5030947509239,10.983036928529,6.92499870880642,5.37719609421162,6.3027942835256,5.50214827275671,5.34200756639254,5.87789223200424,6.81676453218693,5.83484890161464,6.42156261490219,7.58496190494083,7.38647027170529,8.43195307552976,7.27395267377144,7.40144070427009,7.65326431944636,6.8041700115127,7.60661241161144,7.15999448364864,6.20914414653046,6.68701476636996,58489,"abhydrolase domain containing 17C%2C depalmitoylase","protein_coding",null,null,"GO:0002084,GO:0005515,GO:0005886,GO:0008474,GO:0010008,GO:0043197,GO:0055038,GO:0098839,GO:0098978,GO:0099175,GO:1902817,GO:1905668","protein depalmitoylation|protein binding|plasma membrane|palmitoyl-(protein) hydrolase activity|endosome membrane|dendritic spine|recycling endosome membrane|postsynaptic density membrane|glutamatergic synapse|regulation of postsynapse organization|negative regulation of protein localization to microtubule|positive regulation of protein localization to endosome",null,null,"R-HSA-162582,R-HSA-5673001,R-HSA-5683057,R-HSA-5684996,R-HSA-9648002","Signal Transduction|RAF/MAP kinase cascade|MAPK family signaling cascades|MAPK1/MAPK3 signaling|RAS processing"]
["ABHD18",0.813428841422342,0.899171589313973,0.917001044528907,0.837354892403962,1.05877492636989,0.628186454739678,0.949384754032371,0.773008078251135,1.06776568429828,0.67454162260413,0.676374752611984,0.837335539732576,0.958741006381765,0.72759718069357,0.884998974886147,1.01543493892311,0.89680532719396,0.764260796693676,0.885310526623448,0.966437590359129,1.0019366732374,0.788120621158028,1.09758224997753,1.00027587883046,1.02129859142435,0.623694497926122,1.17311234725018,0.690902823516993,80167,"abhydrolase domain containing 18","protein_coding",null,null,"GO:0005576","extracellular region"]
["ABHD2",20.291698781507,16.6066713150957,11.4297950152135,12.7580880861535,17.7516889903157,14.070241793773,11.5086316106306,12.8640332490489,15.403579425195,12.5588567801528,10.6686518525455,13.7130184676011,14.0267646902642,11.1302979223775,11.9718548882519,12.7598930149495,11.0164531468661,12.2652702067749,9.17979870286335,12.7781288046879,11.3584333623849,10.922091299499,9.56313555292755,10.8517501820823,11.3889958377855,9.85146479819298,8.79401127021039,9.0848540356943,11057,"abhydrolase domain containing 2%2C acylglycerol lipase","protein_coding",null,null,"GO:0001669,GO:0003707,GO:0004806,GO:0007340,GO:0008126,GO:0009611,GO:0014909,GO:0014912,GO:0032570,GO:0033878,GO:0036126,GO:0042562,GO:0043401,GO:0046464,GO:0047372,GO:0048240,GO:0051792,GO:0051793,GO:0097524","acrosomal vesicle|nuclear steroid receptor activity|triglyceride lipase activity|acrosome reaction|acetylesterase activity|response to wounding|smooth muscle cell migration|negative regulation of smooth muscle cell migration|response to progesterone|hormone-sensitive lipase activity|sperm flagellum|hormone binding|steroid hormone mediated signaling pathway|acylglycerol catabolic process|acylglycerol lipase activity|sperm capacitation|medium-chain fatty acid biosynthetic process|medium-chain fatty acid catabolic process|sperm plasma membrane","WP2882,WP2880","Nuclear receptors meta-pathway|Glucocorticoid receptor pathway"]
["ABHD3",3.03833891950408,2.55452211299615,1.7403653933263,2.48032125990978,2.29739164485074,2.11439171232616,1.56923260687847,1.86211604502111,1.9282895895766,1.62863075961463,1.60727743073728,2.33810446151899,2.18427403741324,1.69835352372005,1.74920459931728,1.46612490230195,1.75618488915518,2.17538594710182,1.60462721608629,1.90434261838883,1.86915287961911,2.10587207159592,1.43726491953816,2.03192263645258,2.13369816032685,1.86450046952369,1.86384177327173,1.90426008777984,171586,"abhydrolase domain containing 3%2C phospholipase","protein_coding",null,null,"GO:0004623,GO:0005575,GO:0005886,GO:0006656,GO:0008126,GO:0008970,GO:0046470,GO:0047372,GO:0051792,GO:0051793,GO:0052739,GO:0052740","phospholipase A2 activity|cellular_component|plasma membrane|phosphatidylcholine biosynthetic process|acetylesterase activity|phospholipase A1 activity|phosphatidylcholine metabolic process|acylglycerol lipase activity|medium-chain fatty acid biosynthetic process|medium-chain fatty acid catabolic process|phosphatidylserine 1-acylhydrolase activity|1-acyl-2-lysophosphatidylserine acylhydrolase activity",null,null,"R-HSA-1430728,R-HSA-1483191,R-HSA-1483206,R-HSA-1483257,R-HSA-556833","Metabolism|Synthesis of PC|Glycerophospholipid biosynthesis|Phospholipid metabolism|Metabolism of lipids"]
["ABHD4",15.1735206491681,18.8814194152873,19.8844326176177,19.4793138488568,18.2401988291603,21.2090555546736,19.6414084069603,20.1172879055155,18.8274695461943,24.0668133945187,21.0321587522292,18.9944203391393,18.6267840491589,19.875650027355,19.0316209751177,20.0898246650298,15.5304021183045,13.9133971386853,13.1417972656163,13.1656513489157,14.8683618410216,14.0018814106969,13.3142701782902,13.5256516810117,13.5652270697534,14.20709829459,14.1390120061089,16.1070430116176,63874,"abhydrolase domain containing 4%2C N-acyl phospholipase B","protein_coding",null,null,"GO:0004622,GO:0005515,GO:0005739,GO:0005789,GO:0005811,GO:0006654,GO:0016042,GO:0016787,GO:0036152,GO:0042171,GO:0055088,GO:0070292","lysophospholipase activity|protein binding|mitochondrion|endoplasmic reticulum membrane|lipid droplet|phosphatidic acid biosynthetic process|lipid catabolic process|hydrolase activity|phosphatidylethanolamine acyl-chain remodeling|lysophosphatidic acid acyltransferase activity|lipid homeostasis|N-acylphosphatidylethanolamine metabolic process",null,null,"R-HSA-1430728,R-HSA-1482839,R-HSA-1483206,R-HSA-1483257,R-HSA-556833","Metabolism|Acyl chain remodelling of PE|Glycerophospholipid biosynthesis|Phospholipid metabolism|Metabolism of lipids"]
["ABHD5",3.90644168327129,3.34578805177339,3.31901110756064,3.52188416174617,3.75243870408433,3.12888490197577,3.45501978858254,3.26731445696861,2.36916738714765,1.93653149290532,2.3231272076976,2.29410150557547,3.01737989555294,2.03489095912721,2.76993331157053,2.18295470414156,3.30969874485576,3.29147826872004,4.19853889653819,3.58653901604315,3.59951216825119,3.56199982557542,4.44110323408597,3.7215061360845,3.75464593129613,3.38430851032561,4.39169349567332,3.39831546042701,51099,"abhydrolase domain containing 5%2C lysophosphatidic acid acyltransferase","protein_coding","hsa04923","Regulation of lipolysis in adipocytes","GO:0003841,GO:0004806,GO:0005515,GO:0005654,GO:0005739,GO:0005811,GO:0005829,GO:0006631,GO:0006654,GO:0010891,GO:0010898,GO:0030154,GO:0042171,GO:0043231,GO:0052689,GO:0055088,GO:0060229","1-acylglycerol-3-phosphate O-acyltransferase activity|triglyceride lipase activity|protein binding|nucleoplasm|mitochondrion|lipid droplet|cytosol|fatty acid metabolic process|phosphatidic acid biosynthetic process|negative regulation of sequestering of triglyceride|positive regulation of triglyceride catabolic process|cell differentiation|lysophosphatidic acid acyltransferase activity|intracellular membrane-bounded organelle|carboxylic ester hydrolase activity|lipid homeostasis|lipase activator activity","WP3965,WP5380","Lipid metabolism pathway|5q35 copy number variation","R-HSA-1430728,R-HSA-163560,R-HSA-556833,R-HSA-8979227","Metabolism|Triglyceride catabolism|Metabolism of lipids|Triglyceride metabolism"]
["ABHD6",4.01661834808535,3.81006045472454,3.79149517966313,3.47430115455148,2.91959022247871,3.81291895741934,3.9619014568924,3.03718640498201,2.63106671703505,3.16227653403716,3.07749810913117,3.01702503754704,3.112018425058,3.52676185561086,3.44026217201292,2.64613870098354,3.14620936235876,2.60251749841627,3.2671796233474,2.86264464569409,2.80974674995842,2.93367887180978,3.47907976057105,2.87626685558849,2.96221268206443,2.61020158401893,2.83832286554808,2.47966409380779,57406,"abhydrolase domain containing 6%2C acylglycerol lipase","protein_coding","hsa04723","Retrograde endocannabinoid signaling","GO:0004620,GO:0005515,GO:0005739,GO:0005765,GO:0005886,GO:0009395,GO:0016020,GO:0019369,GO:0030336,GO:0031902,GO:0031966,GO:0032281,GO:0045211,GO:0046464,GO:0046889,GO:0047372,GO:0052651,GO:0060292,GO:0098978,GO:0098982,GO:0099178,GO:0120163,GO:2000124,GO:2001311","phospholipase activity|protein binding|mitochondrion|lysosomal membrane|plasma membrane|phospholipid catabolic process|membrane|arachidonic acid metabolic process|negative regulation of cell migration|late endosome membrane|mitochondrial membrane|AMPA glutamate receptor complex|postsynaptic membrane|acylglycerol catabolic process|positive regulation of lipid biosynthetic process|acylglycerol lipase activity|monoacylglycerol catabolic process|long-term synaptic depression|glutamatergic synapse|GABA-ergic synapse|regulation of retrograde trans-synaptic signaling by endocanabinoid|negative regulation of cold-induced thermogenesis|regulation of endocannabinoid signaling pathway|lysobisphosphatidic acid metabolic process",null,null,"R-HSA-109582,R-HSA-114508,R-HSA-162582,R-HSA-372790,R-HSA-388396,R-HSA-416476,R-HSA-426048,R-HSA-76002","Hemostasis|Effects of PIP2 hydrolysis|Signal Transduction|Signaling by GPCR|GPCR downstream signalling|G alpha (q) signalling events|Arachidonate production from DAG|Platelet activation, signaling and aggregation"]
["ABHD8",5.43876624726746,7.93554088832803,8.97287013677204,8.697709093766,5.74021208377632,7.6733143128066,8.05486685603006,7.02899954783572,6.77193545434832,10.0314628216293,10.515227927311,7.43746701349737,6.99253808675219,9.7788802426226,7.70980080764218,8.48615172113888,8.40200806898303,9.25845275239094,9.78483556864415,8.32743113026808,9.44443872396923,7.88010097609072,7.75414920660002,8.16374218173752,7.70863635335544,9.63319211519227,7.67732892818865,10.5860396437884,79575,"abhydrolase domain containing 8","protein_coding",null,null,"GO:0005515,GO:0016787,GO:0070062","protein binding|hydrolase activity|extracellular exosome"]
["ABI1",11.151268191778,10.6954433917118,10.3558619680886,9.31050748308296,11.8242581023918,10.6004428834817,9.92786370851947,8.90074933744759,11.4319446340298,8.43563016891986,9.27429139714751,9.62347211611575,12.4731149845261,9.33383970873124,11.3862434123948,10.7448048926828,10.8320693999898,9.9370486091861,10.3772474445443,11.2774033056277,11.208863583256,10.5110128968093,14.048083636343,11.5914733235123,11.3276642672167,9.339034224727,11.7255203469128,9.02858961737791,10006,"abl interactor 1","protein_coding","hsa05130,hsa05132","Pathogenic Escherichia coli infection|Salmonella infection","GO:0001756,GO:0005515,GO:0005622,GO:0005634,GO:0005783,GO:0005829,GO:0005856,GO:0007169,GO:0008092,GO:0008154,GO:0008285,GO:0014069,GO:0017124,GO:0030027,GO:0030296,GO:0030426,GO:0031209,GO:0032433,GO:0035591,GO:0035855,GO:0045296,GO:0048813,GO:0061098,GO:0070062,GO:0072673","somitogenesis|protein binding|intracellular anatomical structure|nucleus|endoplasmic reticulum|cytosol|cytoskeleton|transmembrane receptor protein tyrosine kinase signaling pathway|cytoskeletal protein binding|actin polymerization or depolymerization|negative regulation of cell population proliferation|postsynaptic density|SH3 domain binding|lamellipodium|protein tyrosine kinase activator activity|growth cone|SCAR complex|filopodium tip|signaling adaptor activity|megakaryocyte development|cadherin binding|dendrite morphogenesis|positive regulation of protein tyrosine kinase activity|extracellular exosome|lamellipodium morphogenesis","WP437","EGF/EGFR signaling pathway","R-HSA-162582,R-HSA-162582,R-HSA-1643685,R-HSA-1643685,R-HSA-168249,R-HSA-168249,R-HSA-168256,R-HSA-168256,R-HSA-194138,R-HSA-194315,R-HSA-194315,R-HSA-195258,R-HSA-195258,R-HSA-2029480,R-HSA-2029480,R-HSA-2029482,R-HSA-2029482,R-HSA-4420097,R-HSA-5663205,R-HSA-5663205,R-HSA-5663213,R-HSA-5663213,R-HSA-9006934,R-HSA-9012999,R-HSA-9013149,R-HSA-9013404,R-HSA-9013423,R-HSA-9658195,R-HSA-9658195,R-HSA-9664407,R-HSA-9664407,R-HSA-9664417,R-HSA-9664417,R-HSA-9664422,R-HSA-9664422,R-HSA-9716542,R-HSA-9716542,R-HSA-9824443,R-HSA-9824443","Signal Transduction|Signal Transduction|Disease|Disease|Innate Immune System|Innate Immune System|Immune System|Immune System|Signaling by VEGF|Signaling by Rho GTPases|Signaling by Rho GTPases|RHO GTPase Effectors|RHO GTPase Effectors|Fcgamma receptor (FCGR) dependent phagocytosis|Fcgamma receptor (FCGR) dependent phagocytosis|Regulation of actin dynamics for phagocytic cup formation|Regulation of actin dynamics for phagocytic cup formation|VEGFA-VEGFR2 Pathway|Infectious disease|Infectious disease|RHO GTPases Activate WASPs and WAVEs|RHO GTPases Activate WASPs and WAVEs|Signaling by Receptor Tyrosine Kinases|RHO GTPase cycle|RAC1 GTPase cycle|RAC2 GTPase cycle|RAC3 GTPase cycle|Leishmania infection|Leishmania infection|Parasite infection|Parasite infection|Leishmania phagocytosis|Leishmania phagocytosis|FCGR3A-mediated phagocytosis|FCGR3A-mediated phagocytosis|Signaling by Rho GTPases, Miro GTPases and RHOBTB3|Signaling by Rho GTPases, Miro GTPases and RHOBTB3|Parasitic Infection Pathways|Parasitic Infection Pathways"]
["ABI2",10.716705802725,10.1835890077181,10.0676599956557,9.08848936261164,10.6024779390135,9.63885694101016,9.43281275840347,9.4202641660633,10.6658304056458,8.44731358436443,8.29344959700513,10.0028975360891,10.0448754607247,9.0999835521044,10.412546365833,10.1967976359041,9.7863139299885,10.2581514923609,8.45438091940134,10.7995969119915,10.6032683009729,10.3527101085325,10.7826842274522,11.028904502928,10.3768338988688,9.48289348892724,9.9028975263977,9.03137511005673,10152,"abl interactor 2","protein_coding","hsa04810","Regulation of actin cytoskeleton","GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0005856,GO:0005912,GO:0007010,GO:0007399,GO:0008093,GO:0008154,GO:0010592,GO:0016477,GO:0016601,GO:0017124,GO:0018108,GO:0019900,GO:0030027,GO:0031209,GO:0031267,GO:0031625,GO:0032433,GO:0035591,GO:0042802,GO:0043197,GO:0061001,GO:0070064,GO:0070309,GO:2000601","protein binding|nucleus|cytoplasm|cytosol|cytoskeleton|adherens junction|cytoskeleton organization|nervous system development|cytoskeletal anchor activity|actin polymerization or depolymerization|positive regulation of lamellipodium assembly|cell migration|Rac protein signal transduction|SH3 domain binding|peptidyl-tyrosine phosphorylation|kinase binding|lamellipodium|SCAR complex|small GTPase binding|ubiquitin protein ligase binding|filopodium tip|signaling adaptor activity|identical protein binding|dendritic spine|regulation of dendritic spine morphogenesis|proline-rich region binding|lens fiber cell morphogenesis|positive regulation of Arp2/3 complex-mediated actin nucleation","WP51","Regulation of actin cytoskeleton","R-HSA-162582,R-HSA-162582,R-HSA-1643685,R-HSA-1643685,R-HSA-168249,R-HSA-168249,R-HSA-168256,R-HSA-168256,R-HSA-194138,R-HSA-194315,R-HSA-194315,R-HSA-195258,R-HSA-195258,R-HSA-2029480,R-HSA-2029480,R-HSA-2029482,R-HSA-2029482,R-HSA-4420097,R-HSA-5663205,R-HSA-5663205,R-HSA-5663213,R-HSA-5663213,R-HSA-9006934,R-HSA-9012999,R-HSA-9013149,R-HSA-9013404,R-HSA-9013423,R-HSA-9658195,R-HSA-9658195,R-HSA-9664407,R-HSA-9664407,R-HSA-9664417,R-HSA-9664417,R-HSA-9664422,R-HSA-9664422,R-HSA-9716542,R-HSA-9716542,R-HSA-9824443,R-HSA-9824443","Signal Transduction|Signal Transduction|Disease|Disease|Innate Immune System|Innate Immune System|Immune System|Immune System|Signaling by VEGF|Signaling by Rho GTPases|Signaling by Rho GTPases|RHO GTPase Effectors|RHO GTPase Effectors|Fcgamma receptor (FCGR) dependent phagocytosis|Fcgamma receptor (FCGR) dependent phagocytosis|Regulation of actin dynamics for phagocytic cup formation|Regulation of actin dynamics for phagocytic cup formation|VEGFA-VEGFR2 Pathway|Infectious disease|Infectious disease|RHO GTPases Activate WASPs and WAVEs|RHO GTPases Activate WASPs and WAVEs|Signaling by Receptor Tyrosine Kinases|RHO GTPase cycle|RAC1 GTPase cycle|RAC2 GTPase cycle|RAC3 GTPase cycle|Leishmania infection|Leishmania infection|Parasite infection|Parasite infection|Leishmania phagocytosis|Leishmania phagocytosis|FCGR3A-mediated phagocytosis|FCGR3A-mediated phagocytosis|Signaling by Rho GTPases, Miro GTPases and RHOBTB3|Signaling by Rho GTPases, Miro GTPases and RHOBTB3|Parasitic Infection Pathways|Parasitic Infection Pathways"]
["ABI3",0.318918602783158,0.361124409296796,0.256639027894477,0.349556001613288,0.222595595665224,0.456351726279127,0.269210254796273,0.253162856642615,0.458269832569321,0.745958764826309,1.05687683897775,0.702833150414321,0.202192508988365,0.37644266307127,0.155357984875983,0.115193630409676,0.569438848217242,0.899304079158993,0.561431189102493,0.730187837856725,0.78836442312162,0.692900311538987,0.674663293260245,0.548965023962794,0.451690440236786,0.620490072525361,0.631919143088779,0.713858063590508,51225,"ABI family member 3","protein_coding",null,null,"GO:0002357,GO:0005515,GO:0005737,GO:0010593,GO:0014069,GO:0016020,GO:0017124,GO:0018108,GO:0030027,GO:0030036,GO:0030334,GO:0031209,GO:0042802,GO:0043197,GO:0043198,GO:0051015,GO:0061001,GO:0099151,GO:1900028,GO:1903077,GO:2000774","defense response to tumor cell|protein binding|cytoplasm|negative regulation of lamellipodium assembly|postsynaptic density|membrane|SH3 domain binding|peptidyl-tyrosine phosphorylation|lamellipodium|actin cytoskeleton organization|regulation of cell migration|SCAR complex|identical protein binding|dendritic spine|dendritic shaft|actin filament binding|regulation of dendritic spine morphogenesis|regulation of postsynaptic density assembly|negative regulation of ruffle assembly|negative regulation of protein localization to plasma membrane|positive regulation of cellular senescence"]
["ABI3BP",1.18216406456877,1.33975134091554,0.597096822986074,0.77192452146896,1.488718077825,0.951524829166461,0.559855265108149,0.792784009531926,0.495155809717607,0.366835880633321,0.250060835668556,0.347045914801271,0.430555229417373,0.328865275861536,0.407682455889268,0.585987326114272,0.214188166049079,0.226077217647149,0.262352334350496,0.321342994759261,0.206878548540979,0.170773634389399,0.329897340368301,0.351046177788251,0.317052329585027,0.136567597940706,0.257303725036769,0.206059668982304,25890,"ABI family member 3 binding protein","protein_coding",null,null,"GO:0005201,GO:0005576,GO:0005615,GO:0010811,GO:0030198,GO:0062023","extracellular matrix structural constituent|extracellular region|extracellular space|positive regulation of cell-substrate adhesion|extracellular matrix organization|collagen-containing extracellular matrix"]
["ABITRAM",6.62898993419184,6.93938552255813,7.80598733480824,7.1055385905011,7.36255100952427,7.61878328604492,8.19161640542877,7.57348245483118,6.7817377306961,4.90654577204865,5.89112435089973,6.07451808875207,7.23716687520433,5.94816972195603,7.32304012620154,6.39262832313147,7.30458606044372,7.08794058394258,7.94023642473961,8.47927645309545,7.40841161540327,6.61196942855499,9.31348067768653,7.79127252420237,6.9088473231738,6.81267111827078,9.48214736055119,6.09011201474263,54942,"actin binding transcription modulator","protein_coding",null,null,"GO:0003785,GO:0005515,GO:0005634,GO:0016607,GO:0030027,GO:0030425,GO:0030426,GO:0030833,GO:0032433,GO:0048813,GO:0051015,GO:0051489","actin monomer binding|protein binding|nucleus|nuclear speck|lamellipodium|dendrite|growth cone|regulation of actin filament polymerization|filopodium tip|dendrite morphogenesis|actin filament binding|regulation of filopodium assembly"]
["ABL1",25.1709588121394,29.6117883174117,27.4722230906154,26.2704510438594,26.818985587684,29.6473997113385,25.4952624008357,26.6713855090468,25.6637552126418,33.2150943843107,27.9507471920304,25.1611452896501,25.3307710675218,28.7064816399343,26.9517345734386,28.625909630977,22.0687341512388,25.1592649255669,22.2906592615829,26.3147016917545,24.9404402288218,24.6259626006772,20.772443060427,21.6417332370677,24.2631508268946,22.693246895075,19.7270171429077,22.9458753768761,25,"ABL proto-oncogene 1%2C non-receptor tyrosine kinase","protein_coding","hsa04012,hsa04014,hsa04110,hsa04722,hsa04360,hsa05200,hsa05206,hsa05208,hsa05220,hsa05130,hsa05416","ErbB signaling pathway|Ras signaling pathway|Cell cycle|Neurotrophin signaling pathway|Axon guidance|Pathways in cancer|MicroRNAs in cancer|Chemical carcinogenesis - reactive oxygen species|Chronic myeloid leukemia|Pathogenic Escherichia coli infection|Viral myocarditis","GO:0000278,GO:0000287,GO:0000400,GO:0000405,GO:0001726,GO:0001784,GO:0001843,GO:0001922,GO:0001934,GO:0002322,GO:0002333,GO:0003677,GO:0003713,GO:0003785,GO:0004515,GO:0004672,GO:0004713,GO:0004715,GO:0005080,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005739,GO:0005829,GO:0006298,GO:0006355,GO:0006468,GO:0006914,GO:0006974,GO:0006979,GO:0007173,GO:0007204,GO:0007229,GO:0007249,GO:0008306,GO:0008630,GO:0009410,GO:0009791,GO:0010506,GO:0010595,GO:0015629,GO:0016301,GO:0016604,GO:0017124,GO:0018108,GO:0019905,GO:0021587,GO:0022408,GO:0030035,GO:0030036,GO:0030041,GO:0030100,GO:0030145,GO:0030155,GO:0030182,GO:0030425,GO:0030426,GO:0030509,GO:0030514,GO:0030516,GO:0031113,GO:0031965,GO:0032489,GO:0032729,GO:0032743,GO:0032956,GO:0032991,GO:0033690,GO:0034446,GO:0034599,GO:0034976,GO:0035791,GO:0036211,GO:0038083,GO:0038096,GO:0038189,GO:0038191,GO:0042169,GO:0042770,GO:0042981,GO:0043025,GO:0043065,GO:0043123,GO:0043124,GO:0043525,GO:0043542,GO:0043621,GO:0045580,GO:0045907,GO:0045930,GO:0045931,GO:0045944,GO:0046632,GO:0046777,GO:0046875,GO:0048146,GO:0048471,GO:0048536,GO:0048538,GO:0050731,GO:0050798,GO:0050852,GO:0050853,GO:0050885,GO:0051015,GO:0051019,GO:0051281,GO:0051353,GO:0051402,GO:0051444,GO:0051450,GO:0051496,GO:0051649,GO:0051726,GO:0051882,GO:0051894,GO:0060020,GO:0060038,GO:0060563,GO:0070064,GO:0070097,GO:0070301,GO:0070371,GO:0070373,GO:0070374,GO:0071103,GO:0071222,GO:0071560,GO:0071871,GO:0071901,GO:0090050,GO:0090398,GO:0097100,GO:0098609,GO:0098794,GO:1900006,GO:1900026,GO:1900272,GO:1900275,GO:1902036,GO:1903055,GO:1903210,GO:1903351,GO:1903905,GO:1904157,GO:1904518,GO:1904528,GO:1904531,GO:1905244,GO:1905555,GO:1990051,GO:1990837,GO:2000042,GO:2000096,GO:2000145,GO:2000352,GO:2000406,GO:2000773","mitotic cell cycle|magnesium ion binding|four-way junction DNA binding|bubble DNA binding|ruffle|phosphotyrosine residue binding|neural tube closure|B-1 B cell homeostasis|positive regulation of protein phosphorylation|B cell proliferation involved in immune response|transitional one stage B cell differentiation|DNA binding|transcription coactivator activity|actin monomer binding|nicotinate-nucleotide adenylyltransferase activity|protein kinase activity|protein tyrosine kinase activity|non-membrane spanning protein tyrosine kinase activity|protein kinase C binding|protein binding|ATP binding|nucleus|nucleoplasm|nucleolus|cytoplasm|mitochondrion|cytosol|mismatch repair|regulation of DNA-templated transcription|protein phosphorylation|autophagy|DNA damage response|response to oxidative stress|epidermal growth factor receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|integrin-mediated signaling pathway|canonical NF-kappaB signal transduction|associative learning|intrinsic apoptotic signaling pathway in response to DNA damage|response to xenobiotic stimulus|post-embryonic development|regulation of autophagy|positive regulation of endothelial cell migration|actin cytoskeleton|kinase activity|nuclear body|SH3 domain binding|peptidyl-tyrosine phosphorylation|syntaxin binding|cerebellum morphogenesis|negative regulation of cell-cell adhesion|microspike assembly|actin cytoskeleton organization|actin filament polymerization|regulation of endocytosis|manganese ion binding|regulation of cell adhesion|neuron differentiation|dendrite|growth cone|BMP signaling pathway|negative regulation of BMP signaling pathway|regulation of axon extension|regulation of microtubule polymerization|nuclear membrane|regulation of Cdc42 protein signal transduction|positive regulation of type II interferon production|positive regulation of interleukin-2 production|regulation of actin cytoskeleton organization|protein-containing complex|positive regulation of osteoblast proliferation|substrate adhesion-dependent cell spreading|cellular response to oxidative stress|response to endoplasmic reticulum stress|platelet-derived growth factor receptor-beta signaling pathway|protein modification process|peptidyl-tyrosine autophosphorylation|Fc-gamma receptor signaling pathway involved in phagocytosis|neuropilin signaling pathway|neuropilin binding|SH2 domain binding|signal transduction in response to DNA damage|regulation of apoptotic process|neuronal cell body|positive regulation of apoptotic process|positive regulation of canonical NF-kappaB signal transduction|negative regulation of canonical NF-kappaB signal transduction|positive regulation of neuron apoptotic process|endothelial cell migration|protein self-association|regulation of T cell differentiation|positive regulation of vasoconstriction|negative regulation of mitotic cell cycle|positive regulation of mitotic cell cycle|positive regulation of transcription by RNA polymerase II|alpha-beta T cell differentiation|protein autophosphorylation|ephrin receptor binding|positive regulation of fibroblast proliferation|perinuclear region of cytoplasm|spleen development|thymus development|positive regulation of peptidyl-tyrosine phosphorylation|activated T cell proliferation|T cell receptor signaling pathway|B cell receptor signaling pathway|neuromuscular process controlling balance|actin filament binding|mitogen-activated protein kinase binding|positive regulation of release of sequestered calcium ion into cytosol|positive regulation of oxidoreductase activity|neuron apoptotic process|negative regulation of ubiquitin-protein transferase activity|myoblast proliferation|positive regulation of stress fiber assembly|establishment of localization in cell|regulation of cell cycle|mitochondrial depolarization|positive regulation of focal adhesion assembly|Bergmann glial cell differentiation|cardiac muscle cell proliferation|neuroepithelial cell differentiation|proline-rich region binding|delta-catenin binding|cellular response to hydrogen peroxide|ERK1 and ERK2 cascade|negative regulation of ERK1 and ERK2 cascade|positive regulation of ERK1 and ERK2 cascade|DNA conformation change|cellular response to lipopolysaccharide|cellular response to transforming growth factor beta stimulus|response to epinephrine|negative regulation of protein serine/threonine kinase activity|positive regulation of cell migration involved in sprouting angiogenesis|cellular senescence|supercoiled DNA binding|cell-cell adhesion|postsynapse|positive regulation of dendrite development|positive regulation of substrate adhesion-dependent cell spreading|negative regulation of long-term synaptic potentiation|negative regulation of phospholipase C activity|regulation of hematopoietic stem cell differentiation|positive regulation of extracellular matrix organization|podocyte apoptotic process|cellular response to dopamine|positive regulation of establishment of T cell polarity|DN4 thymocyte differentiation|protein localization to cytoplasmic microtubule plus-end|positive regulation of microtubule binding|positive regulation of actin filament binding|regulation of modification of synaptic structure|positive regulation of blood vessel branching|activation of protein kinase C activity|sequence-specific double-stranded DNA binding|negative regulation of double-strand break repair via homologous recombination|positive regulation of Wnt signaling pathway, planar cell polarity pathway|regulation of cell motility|negative regulation of endothelial cell apoptotic process|positive regulation of T cell migration|negative regulation of cellular senescence","WP3959,WP3640,WP2516,WP2864,WP5323,WP4223,WP673,WP179,WP5353,WP2038,WP5380,WP4298,WP2446,WP710,WP437,WP2272,WP707,WP1742,WP1545,WP1530,WP3888","DNA IR-double strand breaks and cellular response via ATM|Imatinib and chronic myeloid leukemia|ATM signaling pathway|Apoptosis-related network due to altered Notch3 in ovarian cancer|Fatty Acids and Lipoproteins Transport in Hepatocytes|Ras signaling|ErbB signaling pathway|Cell cycle|A network map of Macrophage-stimulating protein (MSP) signaling|Microtubule cytoskeleton regulation|5q35 copy number variation|Acute viral myocarditis|Retinoblastoma gene in cancer|DNA damage response (only ATM dependent)|EGF/EGFR signaling pathway|Pathogenic Escherichia coli infection|DNA damage response|TP53 network|miRNAs involved in DNA damage response|miRNA regulation of DNA damage response|VEGFA-VEGFR2 signaling","R-HSA-109582,R-HSA-1266738,R-HSA-1266738,R-HSA-162582,R-HSA-1640170,R-HSA-1643685,R-HSA-168249,R-HSA-168256,R-HSA-194315,R-HSA-195258,R-HSA-2029480,R-HSA-2029482,R-HSA-212436,R-HSA-212436,R-HSA-376176,R-HSA-376176,R-HSA-422475,R-HSA-422475,R-HSA-428890,R-HSA-428890,R-HSA-453279,R-HSA-525793,R-HSA-525793,R-HSA-5663205,R-HSA-5663213,R-HSA-5685938,R-HSA-5693532,R-HSA-5693538,R-HSA-5693565,R-HSA-5693567,R-HSA-5693606,R-HSA-69231,R-HSA-69236,R-HSA-69278,R-HSA-73857,R-HSA-73857,R-HSA-73894,R-HSA-74160,R-HSA-74160,R-HSA-8878166,R-HSA-8878171,R-HSA-8939236,R-HSA-8940973,R-HSA-8941326,R-HSA-9658195,R-HSA-9664407,R-HSA-9664417,R-HSA-9664422,R-HSA-9675108,R-HSA-9675108,R-HSA-9716542,R-HSA-9824443,R-HSA-983231","Hemostasis|Developmental Biology|Developmental Biology|Signal Transduction|Cell Cycle|Disease|Innate Immune System|Immune System|Signaling by Rho GTPases|RHO GTPase Effectors|Fcgamma receptor (FCGR) dependent phagocytosis|Regulation of actin dynamics for phagocytic cup formation|Generic Transcription Pathway|Generic Transcription Pathway|Signaling by ROBO receptors|Signaling by ROBO receptors|Axon guidance|Axon guidance|Role of ABL in ROBO-SLIT signaling|Role of ABL in ROBO-SLIT signaling|Mitotic G1 phase and G1/S transition|Myogenesis|Myogenesis|Infectious disease|RHO GTPases Activate WASPs and WAVEs|HDR through Single Strand Annealing (SSA)|DNA Double-Strand Break Repair|Homology Directed Repair|Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks|HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)|DNA Double Strand Break Response|Cyclin D associated events in G1|G1 Phase|Cell Cycle, Mitotic|RNA Polymerase II Transcription|RNA Polymerase II Transcription|DNA Repair|Gene expression (Transcription)|Gene expression (Transcription)|Transcriptional regulation by RUNX2|Transcriptional regulation by RUNX1|RUNX1 regulates transcription of genes involved in differentiation of HSCs|RUNX2 regulates osteoblast differentiation|RUNX2 regulates bone development|Leishmania infection|Parasite infection|Leishmania phagocytosis|FCGR3A-mediated phagocytosis|Nervous system development|Nervous system development|Signaling by Rho GTPases, Miro GTPases and RHOBTB3|Parasitic Infection Pathways|Factors involved in megakaryocyte development and platelet production"]
["ABL2",6.59810228512717,5.7064110747568,4.4328613919174,4.68068456152352,6.66571205271411,4.86824979969078,3.86458107052766,4.42806697299992,5.13210479195585,4.01631235076599,3.59503780451237,4.26919557597019,4.83553127243279,3.41816178392598,3.85216887996625,4.15742860252755,4.33484504186216,4.05707382405673,2.811904825204,4.21480987893981,4.08091003282246,3.76968040586677,3.82210660335272,4.26163149387611,4.76941972542972,3.30718296118605,3.18905296494553,3.27379477489081,27,"ABL proto-oncogene 2%2C non-receptor tyrosine kinase","protein_coding","hsa04012,hsa04014,hsa05208,hsa05416","ErbB signaling pathway|Ras signaling pathway|Chemical carcinogenesis - reactive oxygen species|Viral myocarditis","GO:0000287,GO:0001784,GO:0003785,GO:0004672,GO:0004713,GO:0004715,GO:0005515,GO:0005524,GO:0005829,GO:0006468,GO:0007155,GO:0007165,GO:0007204,GO:0010506,GO:0010863,GO:0010976,GO:0015629,GO:0018108,GO:0030100,GO:0030145,GO:0030155,GO:0032956,GO:0035024,GO:0035640,GO:0036211,GO:0042981,GO:0051015,GO:0051353,GO:0071300,GO:1903905,GO:2000145,GO:2000406","magnesium ion binding|phosphotyrosine residue binding|actin monomer binding|protein kinase activity|protein tyrosine kinase activity|non-membrane spanning protein tyrosine kinase activity|protein binding|ATP binding|cytosol|protein phosphorylation|cell adhesion|signal transduction|positive regulation of cytosolic calcium ion concentration|regulation of autophagy|positive regulation of phospholipase C activity|positive regulation of neuron projection development|actin cytoskeleton|peptidyl-tyrosine phosphorylation|regulation of endocytosis|manganese ion binding|regulation of cell adhesion|regulation of actin cytoskeleton organization|negative regulation of Rho protein signal transduction|exploration behavior|protein modification process|regulation of apoptotic process|actin filament binding|positive regulation of oxidoreductase activity|cellular response to retinoic acid|positive regulation of establishment of T cell polarity|regulation of cell motility|positive regulation of T cell migration","WP4223,WP673,WP4298","Ras signaling|ErbB signaling pathway|Acute viral myocarditis","R-HSA-1266738,R-HSA-1266738,R-HSA-1280215,R-HSA-162582,R-HSA-168256,R-HSA-194315,R-HSA-376176,R-HSA-376176,R-HSA-422475,R-HSA-422475,R-HSA-428890,R-HSA-428890,R-HSA-9012999,R-HSA-9013149,R-HSA-9013423,R-HSA-9607240,R-HSA-9675108,R-HSA-9675108,R-HSA-9706369,R-HSA-9716542","Developmental Biology|Developmental Biology|Cytokine Signaling in Immune system|Signal Transduction|Immune System|Signaling by Rho GTPases|Signaling by ROBO receptors|Signaling by ROBO receptors|Axon guidance|Axon guidance|Role of ABL in ROBO-SLIT signaling|Role of ABL in ROBO-SLIT signaling|RHO GTPase cycle|RAC1 GTPase cycle|RAC3 GTPase cycle|FLT3 Signaling|Nervous system development|Nervous system development|Negative regulation of FLT3|Signaling by Rho GTPases, Miro GTPases and RHOBTB3"]
["ABLIM1",0.68458912018087,0.530792295918078,0.58428797202901,0.47351961444235,0.549351220588294,0.504550892151358,0.590327931475793,0.42516043940187,0.210754512938959,0.171829842205808,0.142420011325957,0.156534894280481,0.205175669865499,0.213601717096537,0.241160625843807,0.26750560240203,0.518574704009853,0.531694114976741,0.404552131942841,0.474785057876826,0.532584750280714,0.435790027623255,0.495616126451419,0.33441241361523,0.582051717182145,0.402116639274358,0.407515929057533,0.4407636789431,3983,"actin binding LIM protein 1","protein_coding","hsa04360","Axon guidance","GO:0001725,GO:0003779,GO:0005515,GO:0005737,GO:0007010,GO:0007601,GO:0009887,GO:0015629,GO:0030027,GO:0030032,GO:0046872,GO:0051015,GO:0060271","stress fiber|actin binding|protein binding|cytoplasm|cytoskeleton organization|visual perception|animal organ morphogenesis|actin cytoskeleton|lamellipodium|lamellipodium assembly|metal ion binding|actin filament binding|cilium assembly","WP4673","Male infertility","R-HSA-1266738,R-HSA-373752,R-HSA-418885,R-HSA-422475,R-HSA-9675108","Developmental Biology|Netrin-1 signaling|DCC mediated attractive signaling|Axon guidance|Nervous system development"]
["ABLIM2",0,0.0190950162428393,0.00471187110317443,0,0,0.00942590199852741,0,0,0,4.83379079211414E-3,0,0,0.00477287687121775,0.023924270188602,0.00466749755682657,0.00475862721041647,0,0,0,0,0,0.00477059692865117,0,0.00490327392621012,0,0.00476880524926074,0.00485664390149763,0.00471829477889835,84448,"actin binding LIM protein family member 2","protein_coding","hsa04360","Axon guidance","GO:0005737,GO:0007010,GO:0015629,GO:0030032,GO:0046872,GO:0051015","cytoplasm|cytoskeleton organization|actin cytoskeleton|lamellipodium assembly|metal ion binding|actin filament binding",null,null,"R-HSA-1266738,R-HSA-373752,R-HSA-418885,R-HSA-422475,R-HSA-9675108","Developmental Biology|Netrin-1 signaling|DCC mediated attractive signaling|Axon guidance|Nervous system development"]
["ABLIM3",10.8493140499043,11.7561845234964,11.8758759763478,11.906051249717,10.9379954423632,12.029081347412,10.9557644999474,10.8160054775894,7.40790344072341,8.40014402998868,7.69244600005474,7.41980467563013,7.37342103334888,7.8892698793093,7.09013069675839,7.13480912610083,6.37265332288497,7.30960940218507,6.65851815731116,7.34764211163809,6.93188859357001,7.06200949027934,6.0790240493569,6.55888799688354,7.39281732109025,7.44164458976871,5.88942403174483,7.36923462318587,22885,"actin binding LIM protein family member 3","protein_coding","hsa04360","Axon guidance","GO:0001725,GO:0005515,GO:0005737,GO:0006366,GO:0007010,GO:0015629,GO:0030027,GO:0030032,GO:0045944,GO:0046872,GO:0051015,GO:0060271,GO:0098978,GO:1903955","stress fiber|protein binding|cytoplasm|transcription by RNA polymerase II|cytoskeleton organization|actin cytoskeleton|lamellipodium|lamellipodium assembly|positive regulation of transcription by RNA polymerase II|metal ion binding|actin filament binding|cilium assembly|glutamatergic synapse|positive regulation of protein targeting to mitochondrion",null,null,"R-HSA-1266738,R-HSA-373752,R-HSA-418885,R-HSA-422475,R-HSA-9675108","Developmental Biology|Netrin-1 signaling|DCC mediated attractive signaling|Axon guidance|Nervous system development"]
["ABR",6.82125040999538,7.77764617615062,7.01938253226792,7.27295751812219,7.10145651073895,7.77882528830477,6.50160709391519,7.20391054281246,6.57134113628035,8.71441362900033,7.76023247203537,6.87778041177507,6.73058992187981,7.37439498697834,7.16175745805638,7.35421714338545,6.08610940856945,7.04039226492914,5.94325116089549,6.85509664711136,6.84328428514726,6.45137994091034,5.61489140311948,5.87573730032229,6.58071282059691,6.35361225855514,5.01206189150432,6.7118262668269,29,"ABR activator of RhoGEF and GTPase","protein_coding",null,null,"GO:0005085,GO:0005096,GO:0005515,GO:0005829,GO:0007264,GO:0016020,GO:0030424,GO:0043197,GO:0050804,GO:0051056,GO:0090630,GO:0098685,GO:0098978","guanyl-nucleotide exchange factor activity|GTPase activator activity|protein binding|cytosol|small GTPase mediated signal transduction|membrane|axon|dendritic spine|modulation of chemical synaptic transmission|regulation of small GTPase mediated signal transduction|activation of GTPase activity|Schaffer collateral - CA1 synapse|glutamatergic synapse",null,null,"R-HSA-162582,R-HSA-193648,R-HSA-193704,R-HSA-194315,R-HSA-204998,R-HSA-372790,R-HSA-388396,R-HSA-416482,R-HSA-73887,R-HSA-8980692,R-HSA-9012999,R-HSA-9013026,R-HSA-9013106,R-HSA-9013148,R-HSA-9013149,R-HSA-9013404,R-HSA-9013423,R-HSA-9716542","Signal Transduction|NRAGE signals death through JNK|p75 NTR receptor-mediated signalling|Signaling by Rho GTPases|Cell death signalling via NRAGE, NRIF and NADE|Signaling by GPCR|GPCR downstream signalling|G alpha (12/13) signalling events|Death Receptor Signaling|RHOA GTPase cycle|RHO GTPase cycle|RHOB GTPase cycle|RHOC GTPase cycle|CDC42 GTPase cycle|RAC1 GTPase cycle|RAC2 GTPase cycle|RAC3 GTPase cycle|Signaling by Rho GTPases, Miro GTPases and RHOBTB3"]
["ABRA",0,0,0,0,0,0,0,0,0,0,0,0,0,0.00884054043226568,0,0,0,0,0,0,0,0,0,0,0,0.0352435541710071,0,0,137735,"actin binding Rho activating protein","protein_coding",null,null,"GO:0003779,GO:0005515,GO:0005886,GO:0006366,GO:0006606,GO:0015629,GO:0030017,GO:0035025,GO:0045944,GO:0051091","actin binding|protein binding|plasma membrane|transcription by RNA polymerase II|protein import into nucleus|actin cytoskeleton|sarcomere|positive regulation of Rho protein signal transduction|positive regulation of transcription by RNA polymerase II|positive regulation of DNA-binding transcription factor activity"]
["ABRACL",29.789282601278,24.199093221109,32.4441106601713,30.4796798449724,25.6552426387931,21.7836273347518,30.305505132866,26.7632515538988,22.7692391577561,14.507544136282,24.0581633284189,25.3987232001736,24.2213220407721,25.2180877497506,28.2516827430446,24.122412257713,19.7949092398365,20.71116127284,25.3283020905779,20.4460192808393,23.7747322341255,22.8499529874548,27.7193865853271,27.0205905078742,20.968432212657,21.9351792027892,27.4693598415016,24.7354418933406,58527,"ABRA C-terminal like","protein_coding",null,null,"GO:0032970","regulation of actin filament-based process"]
["ABRAXAS1",5.23141144018059,5.20982696842066,6.81598857468004,4.82856611977648,5.32215832037878,5.13192428217864,6.10824383857055,5.7327148847562,6.29472196093603,2.64063432009635,4.59609026288168,4.72516005788935,6.79900718549286,4.78824435505113,6.84898905233824,6.20167304423359,4.61596257236124,4.24320658643949,5.76675294222793,5.51537433787264,5.68616114448039,5.0077091951982,9.41878849752096,6.36616039068074,5.99103589803231,4.31657787055941,7.51915244588573,4.67540402674745,84142,"abraxas 1%2C BRCA1 A complex subunit","protein_coding","hsa03440","Homologous recombination","GO:0005515,GO:0005634,GO:0005654,GO:0006282,GO:0006302,GO:0006325,GO:0007095,GO:0008017,GO:0008608,GO:0010212,GO:0016604,GO:0031593,GO:0044818,GO:0045739,GO:0070531,GO:0070536,GO:0090307","protein binding|nucleus|nucleoplasm|regulation of DNA repair|double-strand break repair|chromatin organization|mitotic G2 DNA damage checkpoint signaling|microtubule binding|attachment of spindle microtubules to kinetochore|response to ionizing radiation|nuclear body|polyubiquitin modification-dependent protein binding|mitotic G2/M transition checkpoint|positive regulation of DNA repair|BRCA1-A complex|protein K63-linked deubiquitination|mitotic spindle assembly","WP5380,WP4016","5q35 copy number variation|DNA IR-damage and cellular response via ATR","R-HSA-1640170,R-HSA-392499,R-HSA-5688426,R-HSA-5689901,R-HSA-5693532,R-HSA-5693538,R-HSA-5693565,R-HSA-5693567,R-HSA-5693571,R-HSA-5693606,R-HSA-5693607,R-HSA-597592,R-HSA-69473,R-HSA-69481,R-HSA-69620,R-HSA-73894","Cell Cycle|Metabolism of proteins|Deubiquitination|Metalloprotease DUBs|DNA Double-Strand Break Repair|Homology Directed Repair|Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks|HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)|Nonhomologous End-Joining (NHEJ)|DNA Double Strand Break Response|Processing of DNA double-strand break ends|Post-translational protein modification|G2/M DNA damage checkpoint|G2/M Checkpoints|Cell Cycle Checkpoints|DNA Repair"]
["ABRAXAS2",9.3358781749497,9.08688098363028,8.08409102568674,7.32808484804421,8.05093989499994,6.62196238657071,7.01051498383086,7.19046507115353,8.13246610521191,6.24177457843921,7.10912425062575,8.06128107595619,8.92143609076881,6.42054207134871,7.35889372789026,7.8807074805426,7.72100085052373,7.49758678344321,7.63154227100251,8.5330575691969,8.0246215459824,8.19346172652991,10.4603561752423,8.38591243847271,8.26732222491226,7.59612950252639,8.99907373544463,7.40489722015312,23172,"abraxas 2%2C BRISC complex subunit","protein_coding",null,null,"GO:0000278,GO:0002931,GO:0005515,GO:0005634,GO:0005737,GO:0005813,GO:0005829,GO:0007059,GO:0008017,GO:0008608,GO:0030496,GO:0031593,GO:0031616,GO:0036449,GO:0051301,GO:0070536,GO:0070552,GO:0090307","mitotic cell cycle|response to ischemia|protein binding|nucleus|cytoplasm|centrosome|cytosol|chromosome segregation|microtubule binding|attachment of spindle microtubules to kinetochore|midbody|polyubiquitin modification-dependent protein binding|spindle pole centrosome|microtubule minus-end|cell division|protein K63-linked deubiquitination|BRISC complex|mitotic spindle assembly",null,null,"R-HSA-392499,R-HSA-5688426,R-HSA-5689901,R-HSA-597592","Metabolism of proteins|Deubiquitination|Metalloprotease DUBs|Post-translational protein modification"]
["ABT1",6.73218423306275,7.55342686479201,9.15815310069134,8.41548452462504,6.79321217284135,7.24218986270887,7.19545373152656,6.99675423139975,7.02041977621062,7.47198774099387,8.8206524989483,7.40898217551062,6.43708967653908,7.86789173767356,7.74306442553292,7.46870017075988,10.0743400262241,8.51727650468138,10.149948117802,8.62294026870254,10.6162415165613,8.89792027797102,11.3391421550444,8.89482546793358,9.16260376263539,9.5473117683235,10.9817728900222,10.092007677114,29777,"activator of basal transcription 1","protein_coding",null,null,"GO:0000447,GO:0000472,GO:0000480,GO:0003677,GO:0003713,GO:0003723,GO:0005515,GO:0005634,GO:0005667,GO:0005730,GO:0006357,GO:0006366,GO:0021522,GO:0034462,GO:0045893","endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|DNA binding|transcription coactivator activity|RNA binding|protein binding|nucleus|transcription regulator complex|nucleolus|regulation of transcription by RNA polymerase II|transcription by RNA polymerase II|spinal cord motor neuron differentiation|small-subunit processome assembly|positive regulation of DNA-templated transcription"]
["ABTB1",6.34263887888073,6.89638976335134,9.48887689512804,8.68330907315452,5.87840950773743,8.47943054491057,8.45858964136969,9.12757786116259,7.63388644532573,10.1657463764508,11.5996526692073,9.03600477102342,7.21743210167028,10.570586955331,9.75973739132436,8.26321619126438,9.1121820457961,11.1660582221436,12.0596150515061,8.71815424997369,8.11149336032185,9.81424037563044,8.54395102588343,8.58534421691591,8.14831029538064,10.5581348218632,10.8814535037731,10.7194106441536,80325,"ankyrin repeat and BTB domain containing 1","protein_coding",null,null,"GO:0000151,GO:0003746,GO:0005515,GO:0005730,GO:0005737,GO:0005829,GO:0005886,GO:0006414","ubiquitin ligase complex|translation elongation factor activity|protein binding|nucleolus|cytoplasm|cytosol|plasma membrane|translational elongation"]
["ABTB2",1.33544552541571,1.55773093820624,1.65620684243488,1.27022866624298,1.25660999877065,1.4140332701061,1.38952586311902,1.44964843767383,3.0016440460491,4.0650436257969,3.50931037897611,3.27875106722224,3.00513658782947,3.25893140566012,3.29144124755327,3.18375056116345,1.73835202900057,1.83057883085689,2.33643509634141,2.14560597492945,2.05927420948282,1.77087767567446,1.99113166071833,1.97046334812774,1.83615310287896,1.40990383451997,2.08467553166523,1.80829489095047,25841,"ankyrin repeat and BTB domain containing 2","protein_coding",null,null,"GO:0003674,GO:0046982,GO:0097237","molecular_function|protein heterodimerization activity|cellular response to toxic substance"]
["ACAA1",18.2101929752831,19.3091606727377,19.456163114825,20.8222724696331,19.3731590182278,20.4962741239825,19.7777324438223,21.1138488396971,18.7684606143251,22.5039452938053,23.1437261221422,20.049847148113,17.5372526018537,20.8578798612908,18.2830520152416,19.7343417177066,24.5851739178523,25.0958902694811,26.3950449950401,22.468734319891,25.9752473171327,24.5989362404562,23.4466713599154,26.6111172993819,23.9660601288813,26.5880675701364,25.1667220518297,27.5120626020602,30,"acetyl-CoA acyltransferase 1","protein_coding","hsa00071,hsa00592,hsa01040,hsa00280,hsa04146,hsa03320","Fatty acid degradation|alpha-Linolenic acid metabolism|Biosynthesis of unsaturated fatty acids|Valine, leucine and isoleucine degradation|Peroxisome|PPAR signaling pathway","GO:0000038,GO:0003985,GO:0003988,GO:0005515,GO:0005576,GO:0005777,GO:0005782,GO:0005829,GO:0006635,GO:0008206,GO:0008775,GO:0010124,GO:0016020,GO:0016401,GO:0033540,GO:0035580,GO:0036109,GO:0050633","very long-chain fatty acid metabolic process|acetyl-CoA C-acetyltransferase activity|acetyl-CoA C-acyltransferase activity|protein binding|extracellular region|peroxisome|peroxisomal matrix|cytosol|fatty acid beta-oxidation|bile acid metabolic process|acetate CoA-transferase activity|phenylacetate catabolic process|membrane|palmitoyl-CoA oxidase activity|fatty acid beta-oxidation using acyl-CoA oxidase|specific granule lumen|alpha-linolenic acid metabolic process|acetyl-CoA C-myristoyltransferase activity","WP5323,WP2878,WP1941,WP2882,WP4719,WP3942,WP4721,WP3925","Fatty Acids and Lipoproteins Transport in Hepatocytes|PPAR-alpha pathway|Peroxisomal beta-oxidation of tetracosanoyl-CoA|Nuclear receptors meta-pathway|Eicosanoid metabolism via cyclooxygenases (COX)|PPAR signaling pathway|Eicosanoid metabolism via lipooxygenases (LOX)|Amino acid metabolism","R-HSA-1430728,R-HSA-168249,R-HSA-168256,R-HSA-2046104,R-HSA-2046106,R-HSA-390247,R-HSA-390918,R-HSA-556833,R-HSA-6798695,R-HSA-8978868,R-HSA-9033241,R-HSA-9033241,R-HSA-9033500,R-HSA-9609507,R-HSA-9609507","Metabolism|Innate Immune System|Immune System|alpha-linolenic (omega3) and linoleic (omega6) acid metabolism|alpha-linolenic acid (ALA) metabolism|Beta-oxidation of very long chain fatty acids|Peroxisomal lipid metabolism|Metabolism of lipids|Neutrophil degranulation|Fatty acid metabolism|Peroxisomal protein import|Peroxisomal protein import|TYSND1 cleaves peroxisomal proteins|Protein localization|Protein localization"]
["ACAA2",20.756101478128,19.8739375872332,21.2164041805203,22.3360630331389,18.0764461624513,20.2523380832888,20.8780315015606,21.943334151084,24.02849481246,23.0430854492562,25.0648511662156,24.8030192661965,21.6487989267574,22.5990046196727,22.3960028001874,21.1212107842109,25.341036743348,22.7083116280289,24.0705707414313,21.997095779097,21.2167173090147,22.9607591059895,21.091105903396,23.1943072221556,23.2268352859627,24.7553928456624,24.2485623903783,24.7270332843667,10449,"acetyl-CoA acyltransferase 2","protein_coding","hsa00062,hsa00071,hsa00280","Fatty acid elongation|Fatty acid degradation|Valine, leucine and isoleucine degradation","GO:0003723,GO:0003985,GO:0003986,GO:0003988,GO:0005515,GO:0005739,GO:0005759,GO:0006635,GO:0006695,GO:0016290,GO:0047617,GO:0071456,GO:0102991,GO:1901029,GO:1902109","RNA binding|acetyl-CoA C-acetyltransferase activity|acetyl-CoA hydrolase activity|acetyl-CoA C-acyltransferase activity|protein binding|mitochondrion|mitochondrial matrix|fatty acid beta-oxidation|cholesterol biosynthetic process|palmitoyl-CoA hydrolase activity|acyl-CoA hydrolase activity|cellular response to hypoxia|myristoyl-CoA hydrolase activity|negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway|negative regulation of mitochondrial membrane permeability involved in apoptotic process","WP5323,WP5241,WP357","Fatty Acids and Lipoproteins Transport in Hepatocytes|Mitochondrial beta-oxidation|Fatty acid biosynthesis","R-HSA-1430728,R-HSA-556833,R-HSA-77289,R-HSA-8978868","Metabolism|Metabolism of lipids|Mitochondrial Fatty Acid Beta-Oxidation|Fatty acid metabolism"]
["ACACA",10.8796766137167,12.3229161779923,13.4875671255327,10.4681792558188,12.5858943169074,13.6080646763025,13.4850328412751,12.2161220665458,13.2071571755301,12.2257009139283,10.8417934691775,11.7409285812432,14.0951666654394,14.6253198644426,16.1401579445045,16.0884671805572,7.9607820077627,8.42301352282058,7.29505567243824,8.61333458669297,7.60585987438941,7.54313076162897,7.0401002801516,8.28068565133673,8.31663279872399,7.23545818359325,6.97381465621364,7.01466906951567,31,"acetyl-CoA carboxylase alpha","protein_coding","hsa00620,hsa00640,hsa00061,hsa04152,hsa04910,hsa04922,hsa04936","Pyruvate metabolism|Propanoate metabolism|Fatty acid biosynthesis|AMPK signaling pathway|Insulin signaling pathway|Glucagon signaling pathway|Alcoholic liver disease","GO:0001650,GO:0001894,GO:0003989,GO:0005515,GO:0005524,GO:0005739,GO:0005829,GO:0006084,GO:0006633,GO:0015629,GO:0019538,GO:0042802,GO:0046872,GO:0046949,GO:0051289,GO:0055088,GO:0071380,GO:2001295","fibrillar center|tissue homeostasis|acetyl-CoA carboxylase activity|protein binding|ATP binding|mitochondrion|cytosol|acetyl-CoA metabolic process|fatty acid biosynthetic process|actin cytoskeleton|protein metabolic process|identical protein binding|metal ion binding|fatty-acyl-CoA biosynthetic process|protein homotetramerization|lipid homeostasis|cellular response to prostaglandin E stimulus|malonyl-CoA biosynthetic process","WP4932,WP2853,WP5287,WP3934,WP4018,WP1982,WP2857,WP5353,WP2355,WP3965,WP4206,WP4317,WP3932,WP357,WP2034,WP5066,WP1403,WP4577,WP5031,WP3888","7q11.23 copy number variation syndrome|Endoderm differentiation|17q12 copy number variation syndrome|Leptin and adiponectin|Clear cell renal cell carcinoma pathways|Sterol regulatory element-binding proteins (SREBP) signaling|Mesodermal commitment pathway|A network map of Macrophage-stimulating protein (MSP) signaling|Corticotropin-releasing hormone signaling pathway|Lipid metabolism pathway|Hereditary leiomyomatosis and renal cell carcinoma pathway|Mitochondrial fatty acid synthesis pathway|Focal adhesion: PI3K-Akt-mTOR-signaling pathway|Fatty acid biosynthesis|Leptin signaling pathway|FOXA2 pathway|AMP-activated protein kinase signaling|Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway|Biotin metabolism, including IMDs|VEGFA-VEGFR2 signaling","R-HSA-1430728,R-HSA-163685,R-HSA-163765,R-HSA-1643685,R-HSA-1655829,R-HSA-196780,R-HSA-196849,R-HSA-196854,R-HSA-200425,R-HSA-2426168,R-HSA-3296482,R-HSA-3323169,R-HSA-3371599,R-HSA-556833,R-HSA-5668914,R-HSA-75105,R-HSA-8957322,R-HSA-8978868","Metabolism|Integration of energy metabolism|ChREBP activates metabolic gene expression|Disease|Regulation of cholesterol biosynthesis by SREBP (SREBF)|Biotin transport and metabolism|Metabolism of water-soluble vitamins and cofactors|Metabolism of vitamins and cofactors|Carnitine metabolism|Activation of gene expression by SREBF (SREBP)|Defects in vitamin and cofactor metabolism|Defects in biotin (Btn) metabolism|Defective HLCS causes multiple carboxylase deficiency|Metabolism of lipids|Diseases of metabolism|Fatty acyl-CoA biosynthesis|Metabolism of steroids|Fatty acid metabolism"]
["ACACB",0.761226325920802,0.938312976264301,0.862947669943157,0.78965711391245,0.814680067252321,0.960401270553542,0.806845490124164,0.703293730837621,0.648492969775,0.855351607736496,0.781634291340172,0.79451144234057,0.640200906308783,0.780042889978335,0.664593190687684,0.770857385323612,0.438128055343501,0.409664763571483,0.461848740771267,0.522865270504456,0.488765152606378,0.423315213701959,0.375748983007138,0.404733213065789,0.503131636917292,0.405934755928691,0.440972630247825,0.472225577172973,32,"acetyl-CoA carboxylase beta","protein_coding","hsa00620,hsa00640,hsa00061,hsa04152,hsa04910,hsa04922,hsa04920,hsa04936,hsa04931","Pyruvate metabolism|Propanoate metabolism|Fatty acid biosynthesis|AMPK signaling pathway|Insulin signaling pathway|Glucagon signaling pathway|Adipocytokine signaling pathway|Alcoholic liver disease|Insulin resistance","GO:0003989,GO:0005515,GO:0005524,GO:0005634,GO:0005739,GO:0005741,GO:0005829,GO:0006084,GO:0006633,GO:0009374,GO:0009410,GO:0010629,GO:0010884,GO:0010906,GO:0014070,GO:0031667,GO:0031999,GO:0042802,GO:0046872,GO:0051289,GO:0060421,GO:0097009,GO:2001295","acetyl-CoA carboxylase activity|protein binding|ATP binding|nucleus|mitochondrion|mitochondrial outer membrane|cytosol|acetyl-CoA metabolic process|fatty acid biosynthetic process|biotin binding|response to xenobiotic stimulus|negative regulation of gene expression|positive regulation of lipid storage|regulation of glucose metabolic process|response to organic cyclic compound|response to nutrient levels|negative regulation of fatty acid beta-oxidation|identical protein binding|metal ion binding|protein homotetramerization|positive regulation of heart growth|energy homeostasis|malonyl-CoA biosynthetic process","WP4932,WP4018,WP4206,WP4754,WP2380,WP357,WP2034,WP1403,WP5031,WP3888","7q11.23 copy number variation syndrome|Clear cell renal cell carcinoma pathways|Hereditary leiomyomatosis and renal cell carcinoma pathway|IL-18 signaling pathway|Brain-derived neurotrophic factor (BDNF) signaling pathway|Fatty acid biosynthesis|Leptin signaling pathway|AMP-activated protein kinase signaling|Biotin metabolism, including IMDs|VEGFA-VEGFR2 signaling","R-HSA-1430728,R-HSA-163685,R-HSA-163765,R-HSA-1655829,R-HSA-196780,R-HSA-196849,R-HSA-196854,R-HSA-200425,R-HSA-2426168,R-HSA-556833,R-HSA-8957322,R-HSA-8978868","Metabolism|Integration of energy metabolism|ChREBP activates metabolic gene expression|Regulation of cholesterol biosynthesis by SREBP (SREBF)|Biotin transport and metabolism|Metabolism of water-soluble vitamins and cofactors|Metabolism of vitamins and cofactors|Carnitine metabolism|Activation of gene expression by SREBF (SREBP)|Metabolism of lipids|Metabolism of steroids|Fatty acid metabolism"]
["ACAD10",5.63588105796617,6.768065228348,7.23599481891087,7.4612347634344,6.71524771097881,7.89842871578459,7.57749039939499,7.29991716562157,7.17050487799164,8.3416287835165,8.73268503698969,7.75429745752894,6.52291581052669,8.60201191076121,8.04242623364135,7.86897693947289,4.91906454635965,5.56151642482767,4.52199334184406,5.12235942365702,5.07115428286453,4.50697576746262,3.92780918950338,4.24682973757572,4.62260003884679,4.9864298338707,4.34008135090306,5.17473080568347,80724,"acyl-CoA dehydrogenase family member 10","protein_coding",null,null,"GO:0003995,GO:0005737,GO:0005739,GO:0005759,GO:0006635,GO:0033539,GO:0050660","acyl-CoA dehydrogenase activity|cytoplasm|mitochondrion|mitochondrial matrix|fatty acid beta-oxidation|fatty acid beta-oxidation using acyl-CoA dehydrogenase|flavin adenine dinucleotide binding","WP5323","Fatty Acids and Lipoproteins Transport in Hepatocytes","R-HSA-1430728,R-HSA-556833,R-HSA-77289,R-HSA-8978868","Metabolism|Metabolism of lipids|Mitochondrial Fatty Acid Beta-Oxidation|Fatty acid metabolism"]
["ACAD11",0.525608653611982,0.484069890642038,0.383802390919945,0.416073699433953,0.652193842658863,0.49357331119587,0.326925418154102,0.400874605503513,0.973462896172736,1.12495222786205,0.321690263898741,0.688287143856421,0.967961883128409,0.843126527353517,0.574161428025672,0.909699002142338,0.449191895124902,0.393693427759729,0.223612430045271,0.505436428154307,0.637838524151323,0.452028454941433,0.485945963662293,0.652070176605994,0.769243778211983,0.451858687912543,0.573208740959767,0.313735205911025,84129,"acyl-CoA dehydrogenase family member 11","protein_coding",null,null,"GO:0003995,GO:0004466,GO:0005515,GO:0005634,GO:0005737,GO:0005739,GO:0005743,GO:0005777,GO:0006635,GO:0017099,GO:0031966,GO:0033539,GO:0050660,GO:0070991","acyl-CoA dehydrogenase activity|long-chain-acyl-CoA dehydrogenase activity|protein binding|nucleus|cytoplasm|mitochondrion|mitochondrial inner membrane|peroxisome|fatty acid beta-oxidation|very-long-chain-acyl-CoA dehydrogenase activity|mitochondrial membrane|fatty acid beta-oxidation using acyl-CoA dehydrogenase|flavin adenine dinucleotide binding|medium-chain-acyl-CoA dehydrogenase activity","WP4963,WP5323","p53 transcriptional gene network|Fatty Acids and Lipoproteins Transport in Hepatocytes","R-HSA-1430728,R-HSA-556833,R-HSA-77289,R-HSA-8978868","Metabolism|Metabolism of lipids|Mitochondrial Fatty Acid Beta-Oxidation|Fatty acid metabolism"]
["ACAD8",4.23391001369292,3.87120198617195,3.96589171609146,3.97269509958125,3.98641235814769,3.7947248169381,3.23934380594706,3.86803966854936,3.66212796286202,3.75268883690726,3.74139153188136,3.89579863154037,3.01292932749177,4.07789142566385,3.47111022152984,3.62575300366502,4.8078154760895,4.03349543106697,3.98883552230746,4.49803545556285,4.03259492607648,4.01990381807152,3.66089655622303,3.99507882835564,4.1497880815314,4.08712373353332,3.73309973451789,3.9531646183377,27034,"acyl-CoA dehydrogenase family member 8","protein_coding","hsa00280","Valine, leucine and isoleucine degradation","GO:0003995,GO:0005759,GO:0006574,GO:0006629,GO:0050660","acyl-CoA dehydrogenase activity|mitochondrial matrix|valine catabolic process|lipid metabolic process|flavin adenine dinucleotide binding","WP4686","Leucine, isoleucine and valine metabolism","R-HSA-1430728,R-HSA-70895,R-HSA-71291","Metabolism|Branched-chain amino acid catabolism|Metabolism of amino acids and derivatives"]
["ACAD9",16.839023098759,19.7330296059265,19.837574284588,19.7834998844176,17.2525808703068,19.6203178501596,18.8968620944649,19.4653980688632,17.6109298655222,20.1139029247581,19.9363057256326,19.3079134075556,15.115268895811,17.3675370093975,18.4334525617813,17.6176019637142,16.3505568685176,17.4928382080273,19.4469084618885,19.1549676983138,16.1815009758917,18.2606258322706,16.5752436127216,15.9897445492927,16.3726103410399,18.5062532583751,16.8471799359823,19.5592939387648,28976,"acyl-CoA dehydrogenase family member 9","protein_coding",null,null,"GO:0001676,GO:0003995,GO:0004466,GO:0005515,GO:0005634,GO:0005739,GO:0005743,GO:0030425,GO:0031966,GO:0032981,GO:0050660,GO:0051791,GO:0070991","long-chain fatty acid metabolic process|acyl-CoA dehydrogenase activity|long-chain-acyl-CoA dehydrogenase activity|protein binding|nucleus|mitochondrion|mitochondrial inner membrane|dendrite|mitochondrial membrane|mitochondrial respiratory chain complex I assembly|flavin adenine dinucleotide binding|medium-chain fatty acid metabolic process|medium-chain-acyl-CoA dehydrogenase activity","WP5038,WP5183,WP4324","Mitochondrial immune response to SARS-CoV-2|SARS-CoV-2 mitochondrial chronic oxidative stress and endothelial dysfunction|Mitochondrial complex I assembly model OXPHOS system","R-HSA-1428517,R-HSA-1430728,R-HSA-163200,R-HSA-611105,R-HSA-6799198","The citric acid (TCA) cycle and respiratory electron transport|Metabolism|Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.|Respiratory electron transport|Complex I biogenesis"]
["ACADL",0,0,0.0154691073931234,0,0.00805026858813717,0.00773632634995274,0.0153728028009067,0,0.0414338301146366,0.0238040559392833,0.0387389395110335,0.0663085384280546,0.0313387795541694,0.06283484361026,0.0383085717874625,0.02343391205423,7.92077264423551E-3,0.00762274956308838,0.0152283062447574,0.0158445404913898,0.00777587714514823,0,0.00813316588927557,0.0160974842650822,0.0490067561992845,0.0391400565308365,0.00797219877596082,0.0154901963676424,33,"acyl-CoA dehydrogenase long chain","protein_coding","hsa00071,hsa03320","Fatty acid degradation|PPAR signaling pathway","GO:0000062,GO:0001659,GO:0004466,GO:0005515,GO:0005737,GO:0005739,GO:0005759,GO:0016401,GO:0019254,GO:0031966,GO:0033539,GO:0042413,GO:0042758,GO:0042802,GO:0044242,GO:0045717,GO:0046322,GO:0050660,GO:0090181,GO:0120162","fatty-acyl-CoA binding|temperature homeostasis|long-chain-acyl-CoA dehydrogenase activity|protein binding|cytoplasm|mitochondrion|mitochondrial matrix|palmitoyl-CoA oxidase activity|carnitine metabolic process, CoA-linked|mitochondrial membrane|fatty acid beta-oxidation using acyl-CoA dehydrogenase|carnitine catabolic process|long-chain fatty acid catabolic process|identical protein binding|cellular lipid catabolic process|negative regulation of fatty acid biosynthetic process|negative regulation of fatty acid oxidation|flavin adenine dinucleotide binding|regulation of cholesterol metabolic process|positive regulation of cold-induced thermogenesis","WP368,WP5241,WP5123,WP143,WP3942","Mitochondrial long chain fatty acid beta-oxidation|Mitochondrial beta-oxidation|Mitochondrial fatty acid oxidation disorders|Fatty acid beta-oxidation|PPAR signaling pathway","R-HSA-1430728,R-HSA-556833,R-HSA-77285,R-HSA-77286,R-HSA-77288,R-HSA-77289,R-HSA-77310,R-HSA-8978868","Metabolism|Metabolism of lipids|Beta oxidation of myristoyl-CoA to lauroyl-CoA|mitochondrial fatty acid beta-oxidation of saturated fatty acids|mitochondrial fatty acid beta-oxidation of unsaturated fatty acids|Mitochondrial Fatty Acid Beta-Oxidation|Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA|Fatty acid metabolism"]
["ACADM",10.9324953863001,10.4418544418339,7.86323684457228,6.88820830891278,9.13921335125494,8.30257847287576,9.09722547133187,7.22120617275907,10.1392844455165,7.0487837191495,6.18806543308422,8.94097399399331,10.7101203963881,7.81167967849324,10.3996725580405,8.28606796313489,11.4068743203979,8.12811343547162,10.5136688555816,9.14689558185321,10.2972020312681,8.32851495616298,12.7449041083938,12.379454025003,12.3034229948139,8.44416688074854,13.3834261630044,8.89960106554246,34,"acyl-CoA dehydrogenase medium chain","protein_coding","hsa00071,hsa00280,hsa03320,hsa04936","Fatty acid degradation|Valine, leucine and isoleucine degradation|PPAR signaling pathway|Alcoholic liver disease","GO:0001889,GO:0003995,GO:0005634,GO:0005737,GO:0005739,GO:0005759,GO:0005978,GO:0006111,GO:0006635,GO:0009409,GO:0009791,GO:0019254,GO:0030424,GO:0031966,GO:0033539,GO:0042594,GO:0042802,GO:0045329,GO:0050660,GO:0051791,GO:0051793,GO:0055007,GO:0070991","liver development|acyl-CoA dehydrogenase activity|nucleus|cytoplasm|mitochondrion|mitochondrial matrix|glycogen biosynthetic process|regulation of gluconeogenesis|fatty acid beta-oxidation|response to cold|post-embryonic development|carnitine metabolic process, CoA-linked|axon|mitochondrial membrane|fatty acid beta-oxidation using acyl-CoA dehydrogenase|response to starvation|identical protein binding|carnitine biosynthetic process|flavin adenine dinucleotide binding|medium-chain fatty acid metabolic process|medium-chain fatty acid catabolic process|cardiac muscle cell differentiation|medium-chain-acyl-CoA dehydrogenase activity","WP368,WP5323,WP2878,WP706,WP2882,WP5318,WP5123,WP143,WP3942,WP3925","Mitochondrial long chain fatty acid beta-oxidation|Fatty Acids and Lipoproteins Transport in Hepatocytes|PPAR-alpha pathway|Sudden infant death syndrome (SIDS) susceptibility pathways|Nuclear receptors meta-pathway|Female steroid hormones in cardiomyocyte energy metabolism|Mitochondrial fatty acid oxidation disorders|Fatty acid beta-oxidation|PPAR signaling pathway|Amino acid metabolism","R-HSA-1430728,R-HSA-1989781,R-HSA-400206,R-HSA-556833,R-HSA-77286,R-HSA-77288,R-HSA-77289,R-HSA-77346,R-HSA-77348,R-HSA-8978868","Metabolism|PPARA activates gene expression|Regulation of lipid metabolism by PPARalpha|Metabolism of lipids|mitochondrial fatty acid beta-oxidation of saturated fatty acids|mitochondrial fatty acid beta-oxidation of unsaturated fatty acids|Mitochondrial Fatty Acid Beta-Oxidation|Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA|Beta oxidation of octanoyl-CoA to hexanoyl-CoA|Fatty acid metabolism"]
["ACADS",5.83894006846436,6.88773904615255,8.15307856111882,7.60446054034911,5.75827375913365,7.38250648991368,8.21555188325717,8.03970676187243,5.53408392107224,7.35100366931261,7.73585034005623,6.89197481054215,6.07856311860791,9.21786212768363,6.53377509044011,6.23941487374071,6.5602224384797,7.89797696302108,9.29738755690428,7.23576332171279,6.65658650320049,7.90861158380971,6.56307021677182,7.15366080636183,6.53753559887484,8.39253662377466,7.28136527882873,8.86144618257462,35,"acyl-CoA dehydrogenase short chain","protein_coding","hsa00640,hsa00650,hsa00071,hsa00280,hsa00410","Propanoate metabolism|Butanoate metabolism|Fatty acid degradation|Valine, leucine and isoleucine degradation|beta-Alanine metabolism","GO:0003995,GO:0004085,GO:0005634,GO:0005654,GO:0005739,GO:0005759,GO:0005813,GO:0006635,GO:0033539,GO:0046359,GO:0050660","acyl-CoA dehydrogenase activity|butyryl-CoA dehydrogenase activity|nucleus|nucleoplasm|mitochondrion|mitochondrial matrix|centrosome|fatty acid beta-oxidation|fatty acid beta-oxidation using acyl-CoA dehydrogenase|butyrate catabolic process|flavin adenine dinucleotide binding","WP368,WP5323,WP4754,WP5123,WP143","Mitochondrial long chain fatty acid beta-oxidation|Fatty Acids and Lipoproteins Transport in Hepatocytes|IL-18 signaling pathway|Mitochondrial fatty acid oxidation disorders|Fatty acid beta-oxidation","R-HSA-1430728,R-HSA-556833,R-HSA-77286,R-HSA-77289,R-HSA-77350,R-HSA-77352,R-HSA-8978868","Metabolism|Metabolism of lipids|mitochondrial fatty acid beta-oxidation of saturated fatty acids|Mitochondrial Fatty Acid Beta-Oxidation|Beta oxidation of hexanoyl-CoA to butanoyl-CoA|Beta oxidation of butanoyl-CoA to acetyl-CoA|Fatty acid metabolism"]
["ACADSB",5.00589085934918,4.53344517512226,4.32754098754272,3.17852334244555,4.99063791603734,4.37614666125733,4.05546524888736,3.77875153870581,4.55768730399434,2.87680645403563,3.39426242451161,3.8166754778817,4.83507852391716,3.61673190887804,4.91694449320104,4.47100448740275,3.70492785992829,3.59538297347271,3.8085973085982,4.41040696010502,3.6850105174469,3.82941068992963,4.8463543965528,4.57088175812922,4.003268727338,3.24983476767858,4.63892540539356,3.30641525982289,36,"acyl-CoA dehydrogenase short/branched chain","protein_coding","hsa00071,hsa00280","Fatty acid degradation|Valine, leucine and isoleucine degradation","GO:0003853,GO:0003995,GO:0004085,GO:0005739,GO:0005759,GO:0006550,GO:0006631,GO:0016937,GO:0042802,GO:0050660,GO:0102035","2-methylacyl-CoA dehydrogenase activity|acyl-CoA dehydrogenase activity|butyryl-CoA dehydrogenase activity|mitochondrion|mitochondrial matrix|isoleucine catabolic process|fatty acid metabolic process|short-chain-acyl-CoA dehydrogenase activity|identical protein binding|flavin adenine dinucleotide binding|isobutyryl-CoA:FAD oxidoreductase activity","WP4686,WP5241,WP3871","Leucine, isoleucine and valine metabolism|Mitochondrial beta-oxidation|Valproic acid pathway","R-HSA-1430728,R-HSA-70895,R-HSA-71291","Metabolism|Branched-chain amino acid catabolism|Metabolism of amino acids and derivatives"]
["ACADVL",55.0101480328895,54.9636067903207,54.5330547176702,62.1534541573877,50.120780483045,51.7156802562609,49.4785499280344,54.1966519282143,59.3743761175581,76.9792381400027,74.8835993627278,69.0455297051678,49.1824040132543,54.3410597408476,48.4047039002682,45.9131585208063,76.9637408185498,82.9503449059435,90.1786715146902,78.9898857129174,73.6302855369044,80.3926350901328,74.3144770965807,73.8364825633919,75.1236859828698,81.2578729245604,81.6021648398107,89.0911592266785,37,"acyl-CoA dehydrogenase very long chain","protein_coding","hsa00071,hsa04936","Fatty acid degradation|Alcoholic liver disease","GO:0000062,GO:0001659,GO:0003995,GO:0004466,GO:0005515,GO:0005654,GO:0005730,GO:0005739,GO:0005743,GO:0005759,GO:0009409,GO:0015980,GO:0017099,GO:0030855,GO:0031966,GO:0033539,GO:0042645,GO:0042802,GO:0045717,GO:0046322,GO:0050660,GO:0090181","fatty-acyl-CoA binding|temperature homeostasis|acyl-CoA dehydrogenase activity|long-chain-acyl-CoA dehydrogenase activity|protein binding|nucleoplasm|nucleolus|mitochondrion|mitochondrial inner membrane|mitochondrial matrix|response to cold|energy derivation by oxidation of organic compounds|very-long-chain-acyl-CoA dehydrogenase activity|epithelial cell differentiation|mitochondrial membrane|fatty acid beta-oxidation using acyl-CoA dehydrogenase|mitochondrial nucleoid|identical protein binding|negative regulation of fatty acid biosynthetic process|negative regulation of fatty acid oxidation|flavin adenine dinucleotide binding|regulation of cholesterol metabolic process","WP368,WP5123,WP143","Mitochondrial long chain fatty acid beta-oxidation|Mitochondrial fatty acid oxidation disorders|Fatty acid beta-oxidation","R-HSA-1430728,R-HSA-2262752,R-HSA-381038,R-HSA-381070,R-HSA-381119,R-HSA-556833,R-HSA-77286,R-HSA-77289,R-HSA-77305,R-HSA-8953897,R-HSA-8978868","Metabolism|Cellular responses to stress|XBP1(S) activates chaperone genes|IRE1alpha activates chaperones|Unfolded Protein Response (UPR)|Metabolism of lipids|mitochondrial fatty acid beta-oxidation of saturated fatty acids|Mitochondrial Fatty Acid Beta-Oxidation|Beta oxidation of palmitoyl-CoA to myristoyl-CoA|Cellular responses to stimuli|Fatty acid metabolism"]
["ACAN",0.144408295903088,0.12018671746909,0.0367184125041237,0.0952159728166776,0.188146277288463,0.14973245204279,0.0336829089941296,0.0826036894376182,0.0151307468900771,0.0028975770473711,0,0.00908042150125257,0,0.00573648460638311,0,0.0028525208423155,0,0,0,0.00289304333079394,0,2.85969599372605E-3,0,0,0.00298270286986717,2.85862198591288E-3,0.00291127616014997,0,176,"aggrecan","protein_coding",null,null,"GO:0001501,GO:0002052,GO:0005201,GO:0005515,GO:0005540,GO:0005576,GO:0005615,GO:0005796,GO:0006508,GO:0007155,GO:0007417,GO:0010001,GO:0030021,GO:0030246,GO:0043202,GO:0045202,GO:0046872,GO:0062023,GO:0072534","skeletal system development|positive regulation of neuroblast proliferation|extracellular matrix structural constituent|protein binding|hyaluronic acid binding|extracellular region|extracellular space|Golgi lumen|proteolysis|cell adhesion|central nervous system development|glial cell differentiation|extracellular matrix structural constituent conferring compression resistance|carbohydrate binding|lysosomal lumen|synapse|metal ion binding|collagen-containing extracellular matrix|perineuronal net","WP5373,WP4808,WP2431,WP474","Role of hypoxia, angiogenesis, and FGF pathway in OA chondrocyte hypertrophy|Endochondral ossification with skeletal dysplasias|Spinal cord injury|Endochondral ossification","R-HSA-1430728,R-HSA-1474228,R-HSA-1474228,R-HSA-1474244,R-HSA-1474244,R-HSA-1630316,R-HSA-1638074,R-HSA-1643685,R-HSA-2022854,R-HSA-2022857,R-HSA-3000178,R-HSA-3560782,R-HSA-3656225,R-HSA-3656243,R-HSA-3656244,R-HSA-3781865,R-HSA-5668914,R-HSA-71387","Metabolism|Degradation of the extracellular matrix|Degradation of the extracellular matrix|Extracellular matrix organization|Extracellular matrix organization|Glycosaminoglycan metabolism|Keratan sulfate/keratin metabolism|Disease|Keratan sulfate biosynthesis|Keratan sulfate degradation|ECM proteoglycans|Diseases associated with glycosaminoglycan metabolism|Defective CHST6 causes MCDC1|Defective ST3GAL3 causes MCT12 and EIEE15|Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)|Diseases of glycosylation|Diseases of metabolism|Metabolism of carbohydrates"]
["ACAP1",0.244766265460162,0.14171246065575,0.229795330828443,0.29598294484544,0.197579588467158,0.259828170249972,0.287938119260252,0.448727503616907,0.24620168330889,0.143494695942452,0.19015573561168,0.353322677916878,0.374456968806352,0.324667364062804,0.237528268876893,0.262346330606324,0.368339380698692,0.236320283336046,0.245889350734535,0.245606015733884,0.110489289462366,0.263006229253226,0.178602139528252,0.405481202546114,0.263768433813757,0.323578403395555,0.267750056955601,0.410193608983807,9744,"ArfGAP with coiled-coil%2C ankyrin repeat and PH domains 1","protein_coding","hsa04144","Endocytosis","GO:0005096,GO:0005515,GO:0015031,GO:0016020,GO:0046872,GO:0055038","GTPase activator activity|protein binding|protein transport|membrane|metal ion binding|recycling endosome membrane","WP1433","Nucleotide-binding oligomerization domain (NOD) pathway"]
["ACAP2",8.3983676620376,7.63966324939472,5.47308858966106,4.2957458028068,8.55468723018541,6.53543503081068,5.59414436184477,4.84807957746665,6.5021070623703,4.01330470077776,3.48796360567853,5.0389481007555,8.28688223340855,4.27677168559672,6.3872001334965,6.98485546677441,4.95563579200084,4.86022827429735,4.14597921950042,6.02359007782789,5.35820580836625,5.03168261856814,6.88407378057066,6.45126540350387,5.59126125889783,4.3817234162319,5.39497879039434,3.87275188400807,23527,"ArfGAP with coiled-coil%2C ankyrin repeat and PH domains 2","protein_coding","hsa04144","Endocytosis","GO:0001726,GO:0005096,GO:0010008,GO:0016020,GO:0030029,GO:0032456,GO:0046872,GO:1990090","ruffle|GTPase activator activity|endosome membrane|membrane|actin filament-based process|endocytic recycling|metal ion binding|cellular response to nerve growth factor stimulus"]
["ACAP3",7.26744765389244,9.19353483366292,9.74596683676308,10.6029878856865,7.78060886748099,8.66421890601523,7.28482633283572,9.02363101986816,8.56929576342433,14.9463245680173,13.4169443118563,11.7976107578799,7.4099107737591,10.1798036600028,7.47311049151742,8.01981589577996,7.37017862204405,9.63141303631769,7.00222871028539,8.30963007939696,7.71106253589253,9.05609493173599,5.70193793730057,6.3336998478575,7.30988874143755,8.45407279906261,5.6048211720137,8.65111584543069,116983,"ArfGAP with coiled-coil%2C ankyrin repeat and PH domains 3","protein_coding","hsa04144","Endocytosis","GO:0001764,GO:0005096,GO:0005737,GO:0010975,GO:0030426,GO:0046872","neuron migration|GTPase activator activity|cytoplasm|regulation of neuron projection development|growth cone|metal ion binding","WP5345","1p36 copy number variation syndrome"]
["ACAT1",25.323202196248,23.0510558313109,28.4600954592214,26.2569853897168,25.8535245759806,24.2189436929865,27.0812121095919,28.38785267954,19.880734170891,15.0191406600117,20.5632460949061,21.3351682799851,20.8522320794619,19.6400525982179,21.2117917800636,19.7068625345606,28.4745378666549,24.2535425012183,31.630803256346,23.0980052924294,26.4919268883061,24.4058623639298,32.0233737768093,31.3389266593033,27.8575625488754,26.1231869271027,33.0291732441097,28.5349330541229,38,"acetyl-CoA acetyltransferase 1","protein_coding","hsa00620,hsa00630,hsa00650,hsa00071,hsa00280,hsa00310,hsa00380,hsa00900,hsa04975","Pyruvate metabolism|Glyoxylate and dicarboxylate metabolism|Butanoate metabolism|Fatty acid degradation|Valine, leucine and isoleucine degradation|Lysine degradation|Tryptophan metabolism|Terpenoid backbone biosynthesis|Fat digestion and absorption","GO:0001889,GO:0003985,GO:0005739,GO:0005759,GO:0005783,GO:0006085,GO:0006550,GO:0006635,GO:0009725,GO:0014070,GO:0015936,GO:0015937,GO:0016453,GO:0019899,GO:0030955,GO:0034736,GO:0042594,GO:0042802,GO:0046356,GO:0046952,GO:0060612,GO:0070062,GO:0072229,GO:0120225,GO:1902224,GO:1902860","liver development|acetyl-CoA C-acetyltransferase activity|mitochondrion|mitochondrial matrix|endoplasmic reticulum|acetyl-CoA biosynthetic process|isoleucine catabolic process|fatty acid beta-oxidation|response to hormone|response to organic cyclic compound|coenzyme A metabolic process|coenzyme A biosynthetic process|C-acetyltransferase activity|enzyme binding|potassium ion binding|cholesterol O-acyltransferase activity|response to starvation|identical protein binding|acetyl-CoA catabolic process|ketone body catabolic process|adipose tissue development|extracellular exosome|metanephric proximal convoluted tubule development|coenzyme A binding|ketone body metabolic process|propionyl-CoA biosynthetic process","WP4190,WP4686,WP5195,WP5323,WP4846,WP465,WP5355,WP143,WP4742,WP5175","Mevalonate arm of cholesterol biosynthesis pathway|Leucine, isoleucine and valine metabolism|Disorders in ketolysis|Fatty Acids and Lipoproteins Transport in Hepatocytes|SARS-CoV-2 and COVID-19 pathway|Tryptophan metabolism|Metabolic Epileptic Disorders|Fatty acid beta-oxidation|Ketogenesis and ketolysis|Disorders in ketone body synthesis","R-HSA-1430728,R-HSA-556833,R-HSA-70895,R-HSA-71291,R-HSA-74182,R-HSA-77108,R-HSA-77111","Metabolism|Metabolism of lipids|Branched-chain amino acid catabolism|Metabolism of amino acids and derivatives|Ketone body metabolism|Utilization of Ketone Bodies|Synthesis of Ketone Bodies"]
["ACAT2",37.984430693923,37.6923850092335,36.5366894775118,39.2260717008074,36.56712271166,38.9081901306479,37.7041415121547,42.1972850425315,36.8671075811625,32.1926697406683,33.5365105417864,37.1729817538811,36.0947017987349,35.3102836318309,34.4442403641099,34.9763855979627,44.6462940716152,39.9668838618894,40.9752660649024,38.1067028495097,42.6140272145641,38.8212603900846,43.5783335699693,42.3305669534396,43.0594189856699,41.2540752502774,45.1080578306853,40.9006173177835,39,"acetyl-CoA acetyltransferase 2","protein_coding","hsa00620,hsa00630,hsa00650,hsa00071,hsa00280,hsa00310,hsa00380,hsa00900,hsa04975","Pyruvate metabolism|Glyoxylate and dicarboxylate metabolism|Butanoate metabolism|Fatty acid degradation|Valine, leucine and isoleucine degradation|Lysine degradation|Tryptophan metabolism|Terpenoid backbone biosynthesis|Fat digestion and absorption","GO:0003985,GO:0005515,GO:0005737,GO:0005739,GO:0005829,GO:0006629,GO:0006635,GO:0070062","acetyl-CoA C-acetyltransferase activity|protein binding|cytoplasm|mitochondrion|cytosol|lipid metabolic process|fatty acid beta-oxidation|extracellular exosome","WP4190,WP5195,WP5323,WP4718,WP3963,WP5304,WP5329,WP5333","Mevalonate arm of cholesterol biosynthesis pathway|Disorders in ketolysis|Fatty Acids and Lipoproteins Transport in Hepatocytes|Cholesterol metabolism with Bloch and Kandutsch-Russell pathways|Mevalonate pathway|Cholesterol metabolism|Cholesterol biosynthesis pathway in hepatocytes|Enterocyte cholesterol metabolism","R-HSA-1430728,R-HSA-191273,R-HSA-556833,R-HSA-8957322","Metabolism|Cholesterol biosynthesis|Metabolism of lipids|Metabolism of steroids"]
["ACBD3",20.8715115172432,19.7449607270647,16.6786327566808,14.0587826530079,24.0841933857146,19.1050133384787,17.8870281304242,16.564989864008,21.8487985092713,14.2778109009211,13.4746656363054,17.5554815690883,24.8626347498268,17.3815483573408,22.4111301691407,22.9913179890629,18.9820078798378,15.6581144764109,16.6136402202152,19.4991120495512,19.1316952290744,16.9222510428739,24.1391455874291,20.4717240909267,19.3801118969619,15.1721361902326,19.4764375114033,13.7316095876097,64746,"acyl-CoA binding domain containing 3","protein_coding","hsa05132","Salmonella infection","GO:0000062,GO:0000139,GO:0005515,GO:0005739,GO:0005794,GO:0006694,GO:0016020,GO:0034237","fatty-acyl-CoA binding|Golgi membrane|protein binding|mitochondrion|Golgi apparatus|steroid biosynthetic process|membrane|protein kinase A regulatory subunit binding","WP5329","Cholesterol biosynthesis pathway in hepatocytes","R-HSA-199991,R-HSA-199992,R-HSA-432722,R-HSA-5653656","Membrane Trafficking|trans-Golgi Network Vesicle Budding|Golgi Associated Vesicle Biogenesis|Vesicle-mediated transport"]
["ACBD3-AS1",4.09538870920927,1.0465237983703,0.746024888972672,1.28969783286081,2.32943009976192,1.4923917352453,1.59681938935133,2.45750658825748,2.21341211649128,2.41372767374659,0.517362490122864,3.25934282880938,2.15079252151131,2.09791437033439,1.76222904922716,2.26028318172047,2.4094954461893,0.395898993181352,0.677918612691786,0.940468689121588,0.923090068713832,1.10393343757805,1.81032100610269,3.64277673405476,3.27245114865426,0.638879326375451,1.77449213571046,0.57464764756152,107985353,"ACBD3 antisense RNA 1","non_coding"]
["ACBD4",1.93713030095459,3.14973428705916,3.43453992949472,3.38926749561318,2.82013866467339,3.06045238865952,3.46811028335445,3.27286285899958,2.48827501952242,3.3595291948505,3.05883193055647,2.58757842712071,2.06002070272585,3.27560373736661,3.40219551399441,2.75504066902967,3.14600243893403,3.59682741510865,3.43551180415837,2.79417836860833,3.0205063460195,2.88016305803657,3.04946134225369,3.08174396994395,2.54987423199948,3.53822310110718,2.84345240187661,3.94987597166576,79777,"acyl-CoA binding domain containing 4","protein_coding",null,null,"GO:0000062,GO:0005737,GO:0006631","fatty-acyl-CoA binding|cytoplasm|fatty acid metabolic process",null,null,"R-HSA-1430728,R-HSA-390918,R-HSA-556833,R-HSA-8978868","Metabolism|Peroxisomal lipid metabolism|Metabolism of lipids|Fatty acid metabolism"]
["ACBD5",5.65148569902618,4.70314485094089,3.4040431762165,3.18393148675378,4.79386405145947,4.18750338525943,3.45503592531565,3.2002598324064,4.17061420032021,3.16695909615866,2.54665189202031,3.49572732034826,4.21733704273537,2.91025746898442,3.61401017121665,3.74125692502267,3.1546437873162,3.32555154272336,3.23404324479334,3.98040489537984,3.75084372098959,3.18907029393494,4.2182959333982,3.77595527712777,3.32275823632764,2.61311987490352,3.83193068867667,2.81026315314332,91452,"acyl-CoA binding domain containing 5","protein_coding",null,null,"GO:0000062,GO:0003674,GO:0005654,GO:0005737,GO:0005777,GO:0005778,GO:0005829,GO:0006631,GO:0016020,GO:0016236,GO:0030242,GO:0035973","fatty-acyl-CoA binding|molecular_function|nucleoplasm|cytoplasm|peroxisome|peroxisomal membrane|cytosol|fatty acid metabolic process|membrane|macroautophagy|autophagy of peroxisome|aggrephagy",null,null,"R-HSA-1430728,R-HSA-162582,R-HSA-194315,R-HSA-390918,R-HSA-556833,R-HSA-8978868,R-HSA-8980692,R-HSA-9012999,R-HSA-9013106,R-HSA-9603798,R-HSA-9609507,R-HSA-9716542","Metabolism|Signal Transduction|Signaling by Rho GTPases|Peroxisomal lipid metabolism|Metabolism of lipids|Fatty acid metabolism|RHOA GTPase cycle|RHO GTPase cycle|RHOC GTPase cycle|Class I peroxisomal membrane protein import|Protein localization|Signaling by Rho GTPases, Miro GTPases and RHOBTB3"]
["ACBD6",37.0048585015905,37.6368160464173,47.7377371975797,40.1684700584218,33.3890524258397,38.9193816831293,46.9153687409649,42.7469301442375,33.8247203115084,33.5120360285219,39.3495586745188,37.3977592598944,31.9992934137287,39.4932785844678,39.4552809618337,35.5408654070921,32.2706857138601,35.3580973190946,37.167949646311,33.3593626897699,31.3458417170514,34.560166995361,30.1722967870954,34.340004994926,32.595013870838,36.6865773739207,32.3591609972852,34.9848421071705,84320,"LHX4 antisense RNA 1","protein_coding",null,null,"GO:0000062,GO:0005515,GO:0005829","fatty-acyl-CoA binding|protein binding|cytosol",null,null,"R-HSA-1430728,R-HSA-556833,R-HSA-77289,R-HSA-8978868","Metabolism|Metabolism of lipids|Mitochondrial Fatty Acid Beta-Oxidation|Fatty acid metabolism"]
["ACBD7",0.407942723144628,0.304330362730831,0.90866546679915,0.406583591144536,0.26574963795047,0.285431416334636,1.00002591134302,0.635337575733847,0.522976082420232,0.346677467507426,0.496483766485858,0.362139065213159,0.403163634656219,0.236404445737236,0.766207811841156,0.409544119983956,1.05358968207584,1.2211780516677,2.47656543635066,1.38454014359183,1.00411724407033,1.51304223876952,2.39268569533591,1.23472003344587,0.777166687232334,1.12485502761998,2.32210988679024,1.15805995063777,414149,"acyl-CoA binding domain containing 7","protein_coding",null,null,"GO:0000062,GO:0005515,GO:0006631","fatty-acyl-CoA binding|protein binding|fatty acid metabolic process",null,null,"R-HSA-1430728,R-HSA-556833,R-HSA-77289,R-HSA-8978868","Metabolism|Metabolism of lipids|Mitochondrial Fatty Acid Beta-Oxidation|Fatty acid metabolism"]
["ACBD7-DCLRE1CP1",0.0270373272168938,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,108949267,"ACBD7-DCLRE1CP1 readthrough","non_coding"]
["ACCS",3.06272951310933,4.85527318647287,4.60195311188069,5.00285970099692,4.07918699241757,5.04951927349102,4.80164211708446,4.16211170852476,4.36782861820448,4.8624574912294,4.4125450876134,4.10144541181695,3.8236562810126,5.67987867267966,4.59763280675612,5.12497731661337,3.52952094637296,3.42907065689373,2.42349309498279,3.37553241464194,2.87756267918321,3.33662355488983,2.57488225903027,3.01952893434297,3.47321241886353,3.11611301013815,2.5442212535665,3.16856688095906,84680,"1-aminocyclopropane-1-carboxylate synthase homolog (inactive)","protein_coding",null,null,"GO:0005515,GO:0006520,GO:0008483,GO:0009058,GO:0016847,GO:0030170,GO:0042802","protein binding|amino acid metabolic process|transaminase activity|biosynthetic process|1-aminocyclopropane-1-carboxylate synthase activity|pyridoxal phosphate binding|identical protein binding","WP5348","11p11.2 copy number variation syndrome "]
["ACCSL",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.0133441398052614,0,0.0136275683015131,0,0,0,0,0,0,0,390110,"1-aminocyclopropane-1-carboxylate synthase homolog (inactive) like","protein_coding",null,null,"GO:0006520,GO:0008483,GO:0009058,GO:0030170","amino acid metabolic process|transaminase activity|biosynthetic process|pyridoxal phosphate binding"]
["ACD",7.30772275291023,8.18186719375738,7.95307171797144,8.85156206396888,6.5276356339557,7.46385158523937,6.6838739813246,6.76853509572258,6.62735519263684,10.5133425982597,10.6345340173897,8.77263249698768,6.01716726035417,6.97948233777592,6.18825744580853,5.68932653585859,7.46583911086883,9.0476935764685,8.95291473383586,7.83181344129887,8.0819344628496,9.17055410504057,7.30467159795134,7.63754587104239,7.82827870963237,7.61441517225354,7.17275194080171,9.52474295564203,65057,"ACD shelterin complex subunit and telomerase recruitment factor","protein_coding",null,null,"GO:0000723,GO:0000781,GO:0000783,GO:0001501,GO:0001655,GO:0005515,GO:0005654,GO:0005697,GO:0006886,GO:0007004,GO:0016233,GO:0016604,GO:0030326,GO:0031848,GO:0032202,GO:0032206,GO:0032211,GO:0032212,GO:0035282,GO:0042162,GO:0044877,GO:0051973,GO:0060381,GO:0070182,GO:0070187,GO:0070198,GO:0070200","telomere maintenance|chromosome, telomeric region|nuclear telomere cap complex|skeletal system development|urogenital system development|protein binding|nucleoplasm|telomerase holoenzyme complex|intracellular protein transport|telomere maintenance via telomerase|telomere capping|nuclear body|embryonic limb morphogenesis|protection from non-homologous end joining at telomere|telomere assembly|positive regulation of telomere maintenance|negative regulation of telomere maintenance via telomerase|positive regulation of telomere maintenance via telomerase|segmentation|telomeric DNA binding|protein-containing complex binding|positive regulation of telomerase activity|positive regulation of single-stranded telomeric DNA binding|DNA polymerase binding|shelterin complex|protein localization to chromosome, telomeric region|establishment of protein localization to telomere",null,null,"R-HSA-110328,R-HSA-110329,R-HSA-110330,R-HSA-110330,R-HSA-110331,R-HSA-110331,R-HSA-1221632,R-HSA-1474165,R-HSA-1500620,R-HSA-157579,R-HSA-1640170,R-HSA-1640170,R-HSA-171306,R-HSA-171319,R-HSA-174411,R-HSA-174414,R-HSA-174417,R-HSA-174430,R-HSA-174437,R-HSA-180786,R-HSA-2262752,R-HSA-2559583,R-HSA-2559586,R-HSA-73884,R-HSA-73884,R-HSA-73886,R-HSA-73894,R-HSA-73894,R-HSA-73927,R-HSA-73927,R-HSA-73928,R-HSA-73929,R-HSA-73929,R-HSA-8953897,R-HSA-9670095","Recognition and association of DNA glycosylase with site containing an affected pyrimidine|Cleavage of the damaged pyrimidine |Recognition and association of DNA glycosylase with site containing an affected purine|Recognition and association of DNA glycosylase with site containing an affected purine|Cleavage of the damaged purine|Cleavage of the damaged purine|Meiotic synapsis|Reproduction|Meiosis|Telomere Maintenance|Cell Cycle|Cell Cycle|Packaging Of Telomere Ends|Telomere Extension By Telomerase|Polymerase switching on the C-strand of the telomere|Processive synthesis on the C-strand of the telomere|Telomere C-strand (Lagging Strand) Synthesis|Telomere C-strand synthesis initiation|Removal of the Flap Intermediate from the C-strand|Extension of Telomeres|Cellular responses to stress|Cellular Senescence|DNA Damage/Telomere Stress Induced Senescence|Base Excision Repair|Base Excision Repair|Chromosome Maintenance|DNA Repair|DNA Repair|Depurination|Depurination|Depyrimidination|Base-Excision Repair, AP Site Formation|Base-Excision Repair, AP Site Formation|Cellular responses to stimuli|Inhibition of DNA recombination at telomere"]
["ACE",2.42071811056355,2.86647833701956,1.89541417822246,2.17592150689148,3.25604900888233,3.60303261893229,1.91104534626331,2.57076015846577,1.56248547561621,2.15211859608561,1.47007691021823,1.73044673117489,1.82209281495117,2.20975101623524,1.37171567763904,2.20693123157512,1.33800438794956,1.60504260060543,1.18204432890137,1.39951562778447,1.70203646009169,1.61627667842456,0.536975238258093,0.880881494894042,1.78782158130442,1.28042984426274,0.640152634669589,1.35900355770798,1636,"angiotensin I converting enzyme","protein_coding","hsa04924,hsa04614,hsa05171,hsa05142,hsa05410,hsa05415","Renin secretion|Renin-angiotensin system|Coronavirus disease - COVID-19|Chagas disease|Hypertrophic cardiomyopathy|Diabetic cardiomyopathy","GO:0001666,GO:0001822,GO:0001974,GO:0002003,GO:0002019,GO:0002446,GO:0002474,GO:0003081,GO:0003084,GO:0004175,GO:0004180,GO:0004222,GO:0005516,GO:0005576,GO:0005615,GO:0005764,GO:0005768,GO:0005886,GO:0006508,GO:0007283,GO:0007565,GO:0008217,GO:0008233,GO:0008237,GO:0008238,GO:0008240,GO:0008241,GO:0008270,GO:0008584,GO:0009410,GO:0009792,GO:0009897,GO:0009925,GO:0010608,GO:0010629,GO:0010814,GO:0010815,GO:0014910,GO:0019229,GO:0031100,GO:0031404,GO:0031434,GO:0031526,GO:0031667,GO:0031711,GO:0032496,GO:0032943,GO:0034616,GO:0042310,GO:0042445,GO:0042447,GO:0042755,GO:0043065,GO:0043171,GO:0045907,GO:0046325,GO:0048167,GO:0048286,GO:0050435,GO:0050482,GO:0050769,GO:0051019,GO:0060047,GO:0060177,GO:0060218,GO:0060978,GO:0061098,GO:0070062,GO:0070573,GO:0071333,GO:0071548,GO:0071838,GO:0090281,GO:0097066,GO:0097225,GO:0097746,GO:1900086,GO:1901363,GO:1902033,GO:1903597,GO:1904045,GO:2000170","response to hypoxia|kidney development|blood vessel remodeling|angiotensin maturation|regulation of renal output by angiotensin|neutrophil mediated immunity|antigen processing and presentation of peptide antigen via MHC class I|regulation of systemic arterial blood pressure by renin-angiotensin|positive regulation of systemic arterial blood pressure|endopeptidase activity|carboxypeptidase activity|metalloendopeptidase activity|calmodulin binding|extracellular region|extracellular space|lysosome|endosome|plasma membrane|proteolysis|spermatogenesis|female pregnancy|regulation of blood pressure|peptidase activity|metallopeptidase activity|exopeptidase activity|tripeptidyl-peptidase activity|peptidyl-dipeptidase activity|zinc ion binding|male gonad development|response to xenobiotic stimulus|embryo development ending in birth or egg hatching|external side of plasma membrane|basal plasma membrane|post-transcriptional regulation of gene expression|negative regulation of gene expression|substance P catabolic process|bradykinin catabolic process|regulation of smooth muscle cell migration|regulation of vasoconstriction|animal organ regeneration|chloride ion binding|mitogen-activated protein kinase kinase binding|brush border membrane|response to nutrient levels|bradykinin receptor binding|response to lipopolysaccharide|mononuclear cell proliferation|response to laminar fluid shear stress|vasoconstriction|hormone metabolic process|hormone catabolic process|eating behavior|positive regulation of apoptotic process|peptide catabolic process|positive regulation of vasoconstriction|negative regulation of glucose import|regulation of synaptic plasticity|lung alveolus development|amyloid-beta metabolic process|arachidonic acid secretion|positive regulation of neurogenesis|mitogen-activated protein kinase binding|heart contraction|regulation of angiotensin metabolic process|hematopoietic stem cell differentiation|angiogenesis involved in coronary vascular morphogenesis|positive regulation of protein tyrosine kinase activity|extracellular exosome|metallodipeptidase activity|cellular response to glucose stimulus|response to dexamethasone|cell proliferation in bone marrow|negative regulation of calcium ion import|response to thyroid hormone|sperm midpiece|blood vessel diameter maintenance|positive regulation of peptidyl-tyrosine autophosphorylation|heterocyclic compound binding|regulation of hematopoietic stem cell proliferation|negative regulation of gap junction assembly|cellular response to aldosterone|positive regulation of peptidyl-cysteine S-nitrosylation","WP4969,WP4883,WP4799,WP554,WP5133,WP5038,WP4818,WP5183,WP4756","RAS and bradykinin pathways in COVID-19|SARS-CoV-2 and ACE2 receptor: molecular mechanisms|Downregulation of ACE2 by SARS-CoV-2 spike protein|ACE inhibitor pathway|Non-classical role of vitamin D|Mitochondrial immune response to SARS-CoV-2|Conversion of angiotensinogen to angiotensin II |SARS-CoV-2 mitochondrial chronic oxidative stress and endothelial dysfunction|Renin-angiotensin-aldosterone system (RAAS)","R-HSA-2022377,R-HSA-2980736,R-HSA-392499","Metabolism of Angiotensinogen to Angiotensins|Peptide hormone metabolism|Metabolism of proteins"]
["ACE2",0.0117354006248337,0.00558115652156563,0.0165264212201675,0.0168823983147471,0.011467339495161,0,0.0164235342069765,0.0115076972660156,0.0236084444292714,0.00565134748464194,0.0386276304118725,0,0,0.0111882677564633,0,0.0166904136354899,0.00564143841792307,0.0271458822055128,0.0216922150774254,0,0.00553823901152046,0,0.00579271196989762,5.732582555001E-3,0.00581737433914015,0,0.0056780658238885,0.0110326344177026,59272,"angiotensin converting enzyme 2","protein_coding","hsa04614,hsa04974,hsa05171","Renin-angiotensin system|Protein digestion and absorption|Coronavirus disease - COVID-19","GO:0001618,GO:0001817,GO:0002003,GO:0003051,GO:0003081,GO:0004175,GO:0004180,GO:0004181,GO:0005515,GO:0005576,GO:0005615,GO:0005788,GO:0005886,GO:0005929,GO:0008237,GO:0008241,GO:0008270,GO:0009986,GO:0015827,GO:0016020,GO:0016324,GO:0019058,GO:0019065,GO:0019229,GO:0022898,GO:0030666,GO:0031526,GO:0042127,GO:0042802,GO:0045121,GO:0046718,GO:0046813,GO:0048662,GO:0050727,GO:0051957,GO:0060135,GO:0060452,GO:0061025,GO:0070062,GO:0070373,GO:0097746,GO:0098670,GO:1903598,GO:1903779,GO:1905737,GO:2000272,GO:2000379","virus receptor activity|regulation of cytokine production|angiotensin maturation|angiotensin-mediated drinking behavior|regulation of systemic arterial blood pressure by renin-angiotensin|endopeptidase activity|carboxypeptidase activity|metallocarboxypeptidase activity|protein binding|extracellular region|extracellular space|endoplasmic reticulum lumen|plasma membrane|cilium|metallopeptidase activity|peptidyl-dipeptidase activity|zinc ion binding|cell surface|tryptophan transport|membrane|apical plasma membrane|viral life cycle|receptor-mediated endocytosis of virus by host cell|regulation of vasoconstriction|regulation of transmembrane transporter activity|endocytic vesicle membrane|brush border membrane|regulation of cell population proliferation|identical protein binding|membrane raft|viral entry into host cell|receptor-mediated virion attachment to host cell|negative regulation of smooth muscle cell proliferation|regulation of inflammatory response|positive regulation of amino acid transport|maternal process involved in female pregnancy|positive regulation of cardiac muscle contraction|membrane fusion|extracellular exosome|negative regulation of ERK1 and ERK2 cascade|blood vessel diameter maintenance|entry receptor-mediated virion attachment to host cell|positive regulation of gap junction assembly|regulation of cardiac conduction|positive regulation of L-proline import across plasma membrane|negative regulation of signaling receptor activity|positive regulation of reactive oxygen species metabolic process","WP4969,WP5115,WP4883,WP4799,WP554,WP4912,WP5133,WP5036,WP4846,WP4868,WP5039,WP5076,WP5038,WP4853,WP5113,WP5183,WP5065,WP4891","RAS and bradykinin pathways in COVID-19|Network map of SARS-CoV-2 signaling pathway|SARS-CoV-2 and ACE2 receptor: molecular mechanisms|Downregulation of ACE2 by SARS-CoV-2 spike protein|ACE inhibitor pathway|SARS coronavirus and innate immunity|Non-classical role of vitamin D|Angiotensin II receptor type 1 pathway|SARS-CoV-2 and COVID-19 pathway|Type I interferon induction and signaling during SARS-CoV-2 infection|SARS-CoV-2 innate immunity evasion and cell-specific immune response|Soluble ACE2-mediated cell entry of SARS-CoV-2|Mitochondrial immune response to SARS-CoV-2|Linoleic acid metabolism affected by SARS-CoV-2|Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway|SARS-CoV-2 mitochondrial chronic oxidative stress and endothelial dysfunction|SARS-CoV-2 altering angiogenesis via NRP1|COVID-19 adverse outcome pathway","R-HSA-1643685,R-HSA-1643685,R-HSA-2022377,R-HSA-2980736,R-HSA-392499,R-HSA-5663205,R-HSA-5663205,R-HSA-9678108,R-HSA-9678110,R-HSA-9679191,R-HSA-9679506,R-HSA-9679506,R-HSA-9694516,R-HSA-9694516,R-HSA-9694614,R-HSA-9694614,R-HSA-9733458,R-HSA-9772572,R-HSA-9772572,R-HSA-9772573,R-HSA-9824446,R-HSA-9824446","Disease|Disease|Metabolism of Angiotensinogen to Angiotensins|Peptide hormone metabolism|Metabolism of proteins|Infectious disease|Infectious disease|SARS-CoV-1 Infection|Attachment and Entry|Potential therapeutics for SARS|SARS-CoV Infections|SARS-CoV Infections|SARS-CoV-2 Infection|SARS-CoV-2 Infection|Attachment and Entry|Attachment and Entry|Induction of Cell-Cell Fusion|Early SARS-CoV-2 Infection Events|Early SARS-CoV-2 Infection Events|Late SARS-CoV-2 Infection Events|Viral Infection Pathways|Viral Infection Pathways"]
["ACER1",0.0617553613636726,0,0.014494535907875,0,0,0,0.0144042986152826,0,0.031058761084786,0,0.0290386735578698,0,0,0,0,0.0439150975036888,0.0742175489459868,0.0857100913073031,0,0,0,0.0880511206315651,0,0.0150833243171103,0,0.0146696752541692,0.0149398822422358,0.0435428887585275,125981,"alkaline ceramidase 1","protein_coding","hsa00600,hsa04071","Sphingolipid metabolism|Sphingolipid signaling pathway","GO:0005515,GO:0005783,GO:0005789,GO:0006665,GO:0008544,GO:0010446,GO:0017040,GO:0019216,GO:0030148,GO:0030154,GO:0030216,GO:0046512,GO:0046514,GO:0046872,GO:0048733,GO:0071277,GO:0071633,GO:0102121","protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|sphingolipid metabolic process|epidermis development|response to alkaline pH|N-acylsphingosine amidohydrolase activity|regulation of lipid metabolic process|sphingolipid biosynthetic process|cell differentiation|keratinocyte differentiation|sphingosine biosynthetic process|ceramide catabolic process|metal ion binding|sebaceous gland development|cellular response to calcium ion|dihydroceramidase activity|ceramidase activity","WP1422","Sphingolipid pathway","R-HSA-1430728,R-HSA-1660661,R-HSA-428157,R-HSA-556833","Metabolism|Sphingolipid de novo biosynthesis|Sphingolipid metabolism|Metabolism of lipids"]
["ACER2",0.715211084327189,0.512366101452331,0.293235049364457,0.403743051821393,0.614832335186145,0.310305284071253,0.18582633699756,0.324033952185182,0.19578754531684,0.231066563938805,0.144739867093986,0.296022249220794,0.35729892511348,0.163993138436718,0.134712366093517,0.141634485752451,0.282886637443494,0.242924419997424,0.138059747698062,0.269881348635206,0.247804342753593,0.193623748895104,0.147470481958088,0.23438802110105,0.278245356552243,0.309681648287509,0.140171469460655,0.170223081494294,340485,"alkaline ceramidase 2","protein_coding","hsa00600,hsa04071","Sphingolipid metabolism|Sphingolipid signaling pathway","GO:0000139,GO:0001953,GO:0005794,GO:0006919,GO:0006974,GO:0008284,GO:0010506,GO:0017040,GO:0030148,GO:0030330,GO:0032526,GO:0033629,GO:0042981,GO:0046512,GO:0046514,GO:0046872,GO:0060049,GO:0071466,GO:0071633,GO:0102121","Golgi membrane|negative regulation of cell-matrix adhesion|Golgi apparatus|activation of cysteine-type endopeptidase activity involved in apoptotic process|DNA damage response|positive regulation of cell population proliferation|regulation of autophagy|N-acylsphingosine amidohydrolase activity|sphingolipid biosynthetic process|DNA damage response, signal transduction by p53 class mediator|response to retinoic acid|negative regulation of cell adhesion mediated by integrin|regulation of apoptotic process|sphingosine biosynthetic process|ceramide catabolic process|metal ion binding|regulation of protein glycosylation|cellular response to xenobiotic stimulus|dihydroceramidase activity|ceramidase activity",null,null,"R-HSA-1430728,R-HSA-1660661,R-HSA-428157,R-HSA-556833","Metabolism|Sphingolipid de novo biosynthesis|Sphingolipid metabolism|Metabolism of lipids"]
["ACER3",2.59830003800197,2.52381190543629,1.80439199461332,2.31874859626775,2.81706755776595,2.10369052975445,1.81029064627244,1.90866290580654,2.20719254906585,1.40599596892601,1.4621011698613,1.49641387573775,2.45349768077734,1.3479957287588,1.63085957464021,1.72653940900912,2.27154234411632,2.26536208632381,1.99692749382319,2.31317339233835,2.31664638455697,2.40578094207885,2.67990401526708,2.42484987885718,1.99345329678752,2.02393552266922,2.21225257641042,1.82411483165662,55331,"alkaline ceramidase 3","protein_coding","hsa00600","Sphingolipid metabolism","GO:0000139,GO:0005509,GO:0005789,GO:0006954,GO:0008270,GO:0008284,GO:0016020,GO:0017040,GO:0030148,GO:0042552,GO:0043067,GO:0046512,GO:0046514,GO:0070774,GO:0071602,GO:0071633,GO:0102121","Golgi membrane|calcium ion binding|endoplasmic reticulum membrane|inflammatory response|zinc ion binding|positive regulation of cell population proliferation|membrane|N-acylsphingosine amidohydrolase activity|sphingolipid biosynthetic process|myelination|regulation of programmed cell death|sphingosine biosynthetic process|ceramide catabolic process|phytoceramidase activity|phytosphingosine biosynthetic process|dihydroceramidase activity|ceramidase activity",null,null,"R-HSA-1430728,R-HSA-1660661,R-HSA-428157,R-HSA-556833","Metabolism|Sphingolipid de novo biosynthesis|Sphingolipid metabolism|Metabolism of lipids"]
["ACHE",0.122807358702702,0.102208901720106,0.0504419754743875,0.117779404491948,0.0450008180302702,0.0792841281285589,0.014322269579888,0.0602122565376716,0.26249605538685,0.19220374400785,0.25264142100248,0.262553113718829,0.211679535473806,0.358562955806725,0.192729639293371,0.254712567240928,0.147589795512178,0.134934821992619,0.0638444137664602,0.118094160564527,0.144889920381121,0.0291832301865438,0.0757736867588544,0.149974283927531,0.121754067034213,0.138568282141745,0.00742740159309333,0.0793740244396621,43,"acetylcholinesterase (Cartwright blood group)","protein_coding","hsa00564,hsa04725","Glycerophospholipid metabolism|Cholinergic synapse","GO:0001507,GO:0001540,GO:0001919,GO:0002076,GO:0003990,GO:0004104,GO:0005515,GO:0005518,GO:0005576,GO:0005604,GO:0005615,GO:0005634,GO:0005794,GO:0005886,GO:0006581,GO:0007155,GO:0007399,GO:0007416,GO:0009986,GO:0016020,GO:0016787,GO:0017171,GO:0031594,GO:0031623,GO:0032223,GO:0042166,GO:0042803,GO:0042982,GO:0043083,GO:0043236,GO:0043621,GO:0045202,GO:0048471,GO:0050714,GO:0060041,GO:0095500,GO:0098552,GO:0120162","acetylcholine catabolic process in synaptic cleft|amyloid-beta binding|regulation of receptor recycling|osteoblast development|acetylcholinesterase activity|cholinesterase activity|protein binding|collagen binding|extracellular region|basement membrane|extracellular space|nucleus|Golgi apparatus|plasma membrane|acetylcholine catabolic process|cell adhesion|nervous system development|synapse assembly|cell surface|membrane|hydrolase activity|serine hydrolase activity|neuromuscular junction|receptor internalization|negative regulation of synaptic transmission, cholinergic|acetylcholine binding|protein homodimerization activity|amyloid precursor protein metabolic process|synaptic cleft|laminin binding|protein self-association|synapse|perinuclear region of cytoplasm|positive regulation of protein secretion|retina development in camera-type eye|acetylcholine receptor signaling pathway|side of membrane|positive regulation of cold-induced thermogenesis","WP5055,WP3298,WP528,WP727,WP550","Burn wound healing|Melatonin metabolism and effects|Acetylcholine synthesis|Monoamine transport|Biogenic amine synthesis","R-HSA-112311,R-HSA-112315,R-HSA-112316,R-HSA-1430728,R-HSA-1483191,R-HSA-1483206,R-HSA-1483257,R-HSA-2980736,R-HSA-392499,R-HSA-422085,R-HSA-556833","Neurotransmitter clearance|Transmission across Chemical Synapses|Neuronal System|Metabolism|Synthesis of PC|Glycerophospholipid biosynthesis|Phospholipid metabolism|Peptide hormone metabolism|Metabolism of proteins|Synthesis, secretion, and deacylation of Ghrelin|Metabolism of lipids"]
["ACIN1",31.5457864537343,37.7982609602318,37.0185101890244,38.9806920386417,33.8920688821992,34.8664276111957,33.8485938461037,33.7833735954238,35.1215841781049,40.3544715197746,38.6990219860914,37.7303373060145,31.7303721673286,36.5409889683173,33.7286962988208,33.9767681069878,31.7783895444053,36.4240613766759,34.0231474805695,35.8547744245183,34.6058145223951,34.8928326183594,31.4908636622319,31.1365703097056,34.2636583985417,33.9885010730837,31.4300421862051,34.7740696630288,22985,"apoptotic chromatin condensation inducer 1","protein_coding","hsa03040,hsa03013,hsa03015","Spliceosome|Nucleocytoplasmic transport|mRNA surveillance pathway","GO:0003676,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0005886,GO:0006397,GO:0008380,GO:0016607,GO:0016887,GO:0019899,GO:0030218,GO:0030263,GO:0045657,GO:0061574","nucleic acid binding|RNA binding|protein binding|nucleus|nucleoplasm|cytosol|plasma membrane|mRNA processing|RNA splicing|nuclear speck|ATP hydrolysis activity|enzyme binding|erythrocyte differentiation|apoptotic chromosome condensation|positive regulation of monocyte differentiation|ASAP complex",null,null,"R-HSA-109581,R-HSA-111465,R-HSA-5357801,R-HSA-72163,R-HSA-72172,R-HSA-72203,R-HSA-75153,R-HSA-8953854","Apoptosis|Apoptotic cleavage of cellular proteins|Programmed Cell Death|mRNA Splicing - Major Pathway|mRNA Splicing|Processing of Capped Intron-Containing Pre-mRNA|Apoptotic execution phase|Metabolism of RNA"]
["ACKR2",0.0180309132008315,0.0514511700202124,0.00846403334285949,0.0345853903491408,0.0176190493781838,0.0169319463659166,0.0336453583709477,0.0176810572709283,0.0544099633986987,0.0347321609959131,8.47851572442152E-3,0.0362811936014372,0.0428680964470076,0.0343805365038078,0.0251529726197814,0.017096044646921,0,0.0250250534151423,0.0166645545260355,0.017338908524357,0.0510555251215886,0.00856952378053025,0.0356009615915848,0.0088078542667808,0.017876266029438,0.0171326106981802,0.0174481835417684,0,1238,"atypical chemokine receptor 2","protein_coding",null,null,"GO:0004950,GO:0005044,GO:0005515,GO:0005654,GO:0005769,GO:0005829,GO:0005884,GO:0005886,GO:0006897,GO:0006954,GO:0006955,GO:0007186,GO:0007204,GO:0009897,GO:0016493,GO:0019722,GO:0019957,GO:0031965,GO:0035556,GO:0043231,GO:0055037,GO:0060326,GO:0070098","chemokine receptor activity|scavenger receptor activity|protein binding|nucleoplasm|early endosome|cytosol|actin filament|plasma membrane|endocytosis|inflammatory response|immune response|G protein-coupled receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|external side of plasma membrane|C-C chemokine receptor activity|calcium-mediated signaling|C-C chemokine binding|nuclear membrane|intracellular signal transduction|intracellular membrane-bounded organelle|recycling endosome|cell chemotaxis|chemokine-mediated signaling pathway","WP5323,WP455","Fatty Acids and Lipoproteins Transport in Hepatocytes|GPCRs, class A rhodopsin-like","R-HSA-162582,R-HSA-372790,R-HSA-373076,R-HSA-375276,R-HSA-380108,R-HSA-500792","Signal Transduction|Signaling by GPCR|Class A/1 (Rhodopsin-like receptors)|Peptide ligand-binding receptors|Chemokine receptors bind chemokines|GPCR ligand binding"]
["ACKR3",0.0543910719032347,0.0413879468282042,0.0408514280793379,0.0104328407126645,0,0.0102151976662814,0,0,0.043768036201805,0.0419084589902261,0.0306909951767801,0.120388262464817,0.0206901708436727,0.0311131368481796,0.151750177831207,0.0412567986233202,0,0.0100652286402038,0,0.0104607216480685,0,0.0206802874122562,0,0.0425108704724368,0,0,0,0,57007,"atypical chemokine receptor 3","protein_coding","hsa04060,hsa04061","Cytokine-cytokine receptor interaction|Viral protein interaction with cytokine and cytokine receptor","GO:0001525,GO:0001570,GO:0005044,GO:0005515,GO:0005768,GO:0005769,GO:0005886,GO:0005905,GO:0006955,GO:0007155,GO:0007186,GO:0007204,GO:0008285,GO:0009897,GO:0009986,GO:0015026,GO:0016493,GO:0016494,GO:0019722,GO:0019957,GO:0019958,GO:0021557,GO:0031623,GO:0043231,GO:0055037,GO:0060326,GO:0070098,GO:0070374,GO:1902230,GO:1905322","angiogenesis|vasculogenesis|scavenger receptor activity|protein binding|endosome|early endosome|plasma membrane|clathrin-coated pit|immune response|cell adhesion|G protein-coupled receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|negative regulation of cell population proliferation|external side of plasma membrane|cell surface|coreceptor activity|C-C chemokine receptor activity|C-X-C chemokine receptor activity|calcium-mediated signaling|C-C chemokine binding|C-X-C chemokine binding|oculomotor nerve development|receptor internalization|intracellular membrane-bounded organelle|recycling endosome|cell chemotaxis|chemokine-mediated signaling pathway|positive regulation of ERK1 and ERK2 cascade|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage|positive regulation of mesenchymal stem cell migration","WP5224,WP289,WP455,WP2882,WP2880,WP3888","2q37 copy number variation syndrome|Myometrial relaxation and contraction pathways|GPCRs, class A rhodopsin-like|Nuclear receptors meta-pathway|Glucocorticoid receptor pathway|VEGFA-VEGFR2 signaling","R-HSA-162582,R-HSA-372790,R-HSA-373076,R-HSA-375276,R-HSA-380108,R-HSA-388396,R-HSA-418594,R-HSA-500792","Signal Transduction|Signaling by GPCR|Class A/1 (Rhodopsin-like receptors)|Peptide ligand-binding receptors|Chemokine receptors bind chemokines|GPCR downstream signalling|G alpha (i) signalling events|GPCR ligand binding"]
["ACKR4",1.82022842923382,1.17090572522579,1.68913958152639,1.15034896120298,1.63471355676861,1.94641381106867,1.55100899703387,1.60951451082197,5.51387567543969,3.29342090630158,4.80892675245351,4.27656426842234,5.30312821542334,3.98231149942574,5.25453648549306,5.08777487940863,3.01451869297334,2.3559235168005,2.34354241723574,1.98307844488957,3.36653596269148,2.34026268863614,3.06419088328038,3.20713157236318,3.31715676543916,2.32938639638978,2.20938815913458,2.76961325218175,51554,"atypical chemokine receptor 4","protein_coding","hsa04060,hsa04061","Cytokine-cytokine receptor interaction|Viral protein interaction with cytokine and cytokine receptor","GO:0004950,GO:0005044,GO:0005515,GO:0005769,GO:0005886,GO:0006897,GO:0006935,GO:0006955,GO:0007186,GO:0007204,GO:0009897,GO:0016493,GO:0019722,GO:0019957,GO:0055037,GO:0060326,GO:0070098","chemokine receptor activity|scavenger receptor activity|protein binding|early endosome|plasma membrane|endocytosis|chemotaxis|immune response|G protein-coupled receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|external side of plasma membrane|C-C chemokine receptor activity|calcium-mediated signaling|C-C chemokine binding|recycling endosome|cell chemotaxis|chemokine-mediated signaling pathway","WP5323,WP455","Fatty Acids and Lipoproteins Transport in Hepatocytes|GPCRs, class A rhodopsin-like","R-HSA-162582,R-HSA-372790,R-HSA-373076,R-HSA-375276,R-HSA-380108,R-HSA-500792","Signal Transduction|Signaling by GPCR|Class A/1 (Rhodopsin-like receptors)|Peptide ligand-binding receptors|Chemokine receptors bind chemokines|GPCR ligand binding"]
["ACLY",95.2137314862407,103.184144857121,94.8738049954729,84.3060840206341,97.8674563240819,104.348425814415,98.0266564559957,93.2676353293629,84.4382707326571,82.0932750452343,69.20118000158,77.186865401131,87.6265300734545,83.1240421783038,85.2405435350291,86.641084075235,69.3124190770572,68.155554421972,63.8398413259475,74.4814037269689,70.1279302058405,65.82632188068,67.2391375523092,70.1778502567846,73.8208941553616,63.4736333246504,62.8045164016133,66.200657958848,47,"ATP citrate lyase","protein_coding","hsa00020","Citrate cycle (TCA cycle)","GO:0003878,GO:0005515,GO:0005524,GO:0005576,GO:0005654,GO:0005829,GO:0006085,GO:0006099,GO:0006101,GO:0006107,GO:0006633,GO:0006695,GO:0008610,GO:0015936,GO:0016020,GO:0035578,GO:0046872,GO:0070062,GO:1904813","ATP citrate synthase activity|protein binding|ATP binding|extracellular region|nucleoplasm|cytosol|acetyl-CoA biosynthetic process|tricarboxylic acid cycle|citrate metabolic process|oxaloacetate metabolic process|fatty acid biosynthetic process|cholesterol biosynthetic process|lipid biosynthetic process|coenzyme A metabolic process|membrane|azurophil granule lumen|metal ion binding|extracellular exosome|ficolin-1-rich granule lumen","WP2453,WP5323,WP4018,WP1982,WP3965,WP5220,WP2366,WP357,WP5318,WP4290,WP3925","TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc)|Fatty Acids and Lipoproteins Transport in Hepatocytes|Clear cell renal cell carcinoma pathways|Sterol regulatory element-binding proteins (SREBP) signaling|Lipid metabolism pathway|Metabolic reprogramming in pancreatic cancer|Butyrate-induced histone acetylation|Fatty acid biosynthesis|Female steroid hormones in cardiomyocyte energy metabolism|Metabolic reprogramming in colon cancer|Amino acid metabolism","R-HSA-1430728,R-HSA-163685,R-HSA-163765,R-HSA-168249,R-HSA-168256,R-HSA-556833,R-HSA-6798695,R-HSA-75105,R-HSA-8978868","Metabolism|Integration of energy metabolism|ChREBP activates metabolic gene expression|Innate Immune System|Immune System|Metabolism of lipids|Neutrophil degranulation|Fatty acyl-CoA biosynthesis|Fatty acid metabolism"]
["ACMSD",0,0,0,0,0,0,0.0108638900139453,0.00570911028510536,0,0.0112148122438207,0,0,0,0.00555063737291497,0,0.0276010656016705,0,0,0,0,0,0,0.0344860286691702,0.005688009558893,0,0.0165960602551486,0.0225356668638823,0,130013,"aminocarboxymuconate semialdehyde decarboxylase","protein_coding","hsa00380","Tryptophan metabolism","GO:0001760,GO:0005515,GO:0005737,GO:0005829,GO:0006569,GO:0008270,GO:0016787,GO:0019748,GO:1904985,GO:1905004,GO:1905012","aminocarboxymuconate-semialdehyde decarboxylase activity|protein binding|cytoplasm|cytosol|tryptophan catabolic process|zinc ion binding|hydrolase activity|secondary metabolic process|negative regulation of quinolinate biosynthetic process|picolinic acid biosynthetic process|regulation of 'de novo' NAD biosynthetic process from tryptophan","WP465,WP5044,WP3645","Tryptophan metabolism|Kynurenine pathway and links to cell senescence|NAD+ biosynthetic pathways","R-HSA-1430728,R-HSA-71240,R-HSA-71291","Metabolism|Tryptophan catabolism|Metabolism of amino acids and derivatives"]
["ACO1",19.0350431971802,19.3561251296859,20.1188450240094,19.5269845393398,19.1817181522141,19.8022302177494,20.0201890564588,20.0144426426406,14.9030076483201,12.9519740594759,14.2386500735056,14.5943559174764,14.7033434169428,15.5793367420794,16.5061908037542,15.8013893214019,15.6939477368368,16.8112894742363,13.5484700718525,17.5061206950635,15.6590973705373,15.5972695912666,13.6171795684026,15.9614270087822,16.6709000122158,14.9853612360169,13.882134629748,15.6708122620505,48,"aconitase 1","protein_coding","hsa00020,hsa00630","Citrate cycle (TCA cycle)|Glyoxylate and dicarboxylate metabolism","GO:0003723,GO:0003994,GO:0005515,GO:0005737,GO:0005739,GO:0005783,GO:0005794,GO:0005829,GO:0006099,GO:0006101,GO:0006417,GO:0006879,GO:0009791,GO:0010040,GO:0030350,GO:0046872,GO:0047780,GO:0050892,GO:0051538,GO:0051539,GO:0070062","RNA binding|aconitate hydratase activity|protein binding|cytoplasm|mitochondrion|endoplasmic reticulum|Golgi apparatus|cytosol|tricarboxylic acid cycle|citrate metabolic process|regulation of translation|intracellular iron ion homeostasis|post-embryonic development|response to iron(II) ion|iron-responsive element binding|metal ion binding|citrate dehydratase activity|intestinal absorption|3 iron, 4 sulfur cluster binding|4 iron, 4 sulfur cluster binding|extracellular exosome","WP2453,WP5355,WP2007","TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc)|Metabolic Epileptic Disorders|Iron metabolism in placenta","R-HSA-382551,R-HSA-917937","Transport of small molecules|Iron uptake and transport"]
["ACO2",29.1260402180016,32.0169395643112,32.5250831113729,34.9871053406019,30.652471584771,35.6537684248525,32.7168651566334,33.39808862785,28.626552032384,37.3897681565915,35.6989476565665,31.510769009528,28.1004830905725,29.9297495792498,28.5457044496929,29.7965194305749,27.4872445424901,31.3029945862768,29.6453482326868,30.0947676838444,29.5233153159006,30.6825637275356,26.9326318893745,27.1453182625834,27.2084367863163,32.979862386624,24.1740716702011,31.9582224721036,50,"aconitase 2","protein_coding","hsa00020,hsa00630","Citrate cycle (TCA cycle)|Glyoxylate and dicarboxylate metabolism","GO:0001889,GO:0003994,GO:0005506,GO:0005739,GO:0005759,GO:0005829,GO:0006091,GO:0006099,GO:0006101,GO:0006102,GO:0035900,GO:0047780,GO:0051538,GO:0051539","liver development|aconitate hydratase activity|iron ion binding|mitochondrion|mitochondrial matrix|cytosol|generation of precursor metabolites and energy|tricarboxylic acid cycle|citrate metabolic process|isocitrate metabolic process|response to isolation stress|citrate dehydratase activity|3 iron, 4 sulfur cluster binding|4 iron, 4 sulfur cluster binding","WP78,WP4966,WP4290,WP3925","TCA cycle (aka Krebs or citric acid cycle)|Fluoroacetic acid toxicity|Metabolic reprogramming in colon cancer|Amino acid metabolism","R-HSA-1268020,R-HSA-1428517,R-HSA-1430728,R-HSA-71403,R-HSA-71406,R-HSA-9609507","Mitochondrial protein import|The citric acid (TCA) cycle and respiratory electron transport|Metabolism|Citric acid cycle (TCA cycle)|Pyruvate metabolism and Citric Acid (TCA) cycle|Protein localization"]
["ACOT1",2.02042760463007,1.35307723223327,1.91620536123888,1.8981626091429,1.30946931038242,1.22936290507256,1.90427581862031,1.90035868319966,1.43088840647361,1.49916093384749,1.56079261360584,1.81492682141032,1.30381307182267,1.50363900902456,1.61055974587235,1.29014663503762,1.44697825675833,1.64052064631477,1.62914341942958,1.44725184076918,1.23564783648316,1.54815083150979,0.976950288264676,0.96680936471769,1.24682683025208,1.48880093883536,1.2967703523299,1.25982981394653,641371,"acyl-CoA thioesterase 1","protein_coding","hsa00062,hsa01040,hsa04913","Fatty acid elongation|Biosynthesis of unsaturated fatty acids|Ovarian steroidogenesis","GO:0000038,GO:0001676,GO:0005829,GO:0006631,GO:0006637,GO:0016290,GO:0047617,GO:0052689,GO:0102991","very long-chain fatty acid metabolic process|long-chain fatty acid metabolic process|cytosol|fatty acid metabolic process|acyl-CoA metabolic process|palmitoyl-CoA hydrolase activity|acyl-CoA hydrolase activity|carboxylic ester hydrolase activity|myristoyl-CoA hydrolase activity","WP5064,WP5329,WP4545,WP4723","7-oxo-C and 7-beta-HC pathways|Cholesterol biosynthesis pathway in hepatocytes|Oxysterols derived from cholesterol|Omega-3 / omega-6 fatty acid synthesis","R-HSA-1430728,R-HSA-556833,R-HSA-77289,R-HSA-8978868","Metabolism|Metabolism of lipids|Mitochondrial Fatty Acid Beta-Oxidation|Fatty acid metabolism"]
["ACOT11",0.647617674212764,0.725280733680687,0.529554181169501,0.674531260109599,0.683858982549387,0.676807644294548,0.445044825287113,0.600909298518039,0.238151936584505,0.526489225533179,0.363463521542012,0.276736655276268,0.241715820498278,0.202488570554427,0.174855720278563,0.171667077092694,0.257761707966839,0.315716918612977,0.331450714116711,0.358256071053832,0.450225496330757,0.215123604591327,0.206239101961066,0.363975305550397,0.286512073141671,0.367226954573691,0.192049465320562,0.353517413563163,26027,"acyl-CoA thioesterase 11","protein_coding",null,null,"GO:0005759,GO:0005829,GO:0006631,GO:0006637,GO:0008289,GO:0009266,GO:0009409,GO:0016290,GO:0035556,GO:0047617,GO:0052689,GO:0070062,GO:0102991,GO:0120163","mitochondrial matrix|cytosol|fatty acid metabolic process|acyl-CoA metabolic process|lipid binding|response to temperature stimulus|response to cold|palmitoyl-CoA hydrolase activity|intracellular signal transduction|acyl-CoA hydrolase activity|carboxylic ester hydrolase activity|extracellular exosome|myristoyl-CoA hydrolase activity|negative regulation of cold-induced thermogenesis","WP5064,WP4545","7-oxo-C and 7-beta-HC pathways|Oxysterols derived from cholesterol","R-HSA-1430728,R-HSA-556833,R-HSA-77289,R-HSA-8978868","Metabolism|Metabolism of lipids|Mitochondrial Fatty Acid Beta-Oxidation|Fatty acid metabolism"]
["ACOT12",1.13562769283729,1.42696188427454,1.4421324039143,1.22670775325949,1.03960204656951,1.30775821227751,1.67294270835588,1.35975563278243,0.583167837565579,0.569903934390257,0.668900372484794,0.469041018388425,0.97765874238435,0.820558968795981,1.01721744481639,0.855730953174985,1.01138607188053,0.691287044634844,0.883849543819889,1.00008210076297,1.00980885440966,0.772663226189539,0.802481985676389,0.940135912524525,0.912561580478385,0.795089893376746,1.15098045334674,0.90466868347041,134526,"acyl-CoA thioesterase 12","protein_coding","hsa00620","Pyruvate metabolism","GO:0003986,GO:0005515,GO:0005524,GO:0005654,GO:0005829,GO:0006084,GO:0006631,GO:0006637,GO:0008289,GO:0042802,GO:0045171,GO:0047617,GO:0052689","acetyl-CoA hydrolase activity|protein binding|ATP binding|nucleoplasm|cytosol|acetyl-CoA metabolic process|fatty acid metabolic process|acyl-CoA metabolic process|lipid binding|identical protein binding|intercellular bridge|acyl-CoA hydrolase activity|carboxylic ester hydrolase activity","WP5064,WP4545","7-oxo-C and 7-beta-HC pathways|Oxysterols derived from cholesterol","R-HSA-1430728,R-HSA-556833,R-HSA-77289,R-HSA-8978868","Metabolism|Metabolism of lipids|Mitochondrial Fatty Acid Beta-Oxidation|Fatty acid metabolism"]
["ACOT13",7.19662466788476,6.1227684489873,7.84940378073586,7.29006912429214,6.5759948279067,6.93922388056186,8.46849008022385,7.52704658302693,5.81736333457272,4.90465438839632,6.05373855070786,5.78731122599924,6.6426343001613,5.99456017250861,6.7738756055259,5.87316254351297,7.06276820981236,6.52629889937454,8.20477225344558,6.79470980527531,6.87480921989428,6.49744063786522,8.50591658313121,7.39583114488044,7.35709494575052,7.15159881512225,8.64480932026428,7.75475719772252,55856,"acyl-CoA thioesterase 13","protein_coding",null,null,"GO:0005515,GO:0005634,GO:0005759,GO:0005819,GO:0005829,GO:0006629,GO:0016290,GO:0046872,GO:0047617,GO:0051289,GO:0102991,GO:0120163","protein binding|nucleus|mitochondrial matrix|spindle|cytosol|lipid metabolic process|palmitoyl-CoA hydrolase activity|metal ion binding|acyl-CoA hydrolase activity|protein homotetramerization|myristoyl-CoA hydrolase activity|negative regulation of cold-induced thermogenesis","WP5064,WP4545","7-oxo-C and 7-beta-HC pathways|Oxysterols derived from cholesterol","R-HSA-1430728,R-HSA-556833,R-HSA-77289,R-HSA-8978868","Metabolism|Metabolism of lipids|Mitochondrial Fatty Acid Beta-Oxidation|Fatty acid metabolism"]
["ACOT2",9.14611195514561,9.60313579104242,11.3690534348542,11.056363471596,9.82398710344706,10.3063982632262,12.0788340947,11.3463836854028,8.98580116203128,9.24590771340837,9.68156403136811,10.0006600442762,8.5225654386093,11.0314319020844,9.46850862346119,8.86013080819032,8.45260190268381,10.3387741280878,9.4097314433413,9.25871264472249,9.47575506228243,9.85287871218683,8.37128239676296,8.76925909263967,8.57562377987691,8.63655716413079,9.00146373649822,9.97148186248414,10965,"acyl-CoA thioesterase 2","protein_coding","hsa00062,hsa01040,hsa04913","Fatty acid elongation|Biosynthesis of unsaturated fatty acids|Ovarian steroidogenesis","GO:0000038,GO:0001676,GO:0005515,GO:0005739,GO:0005759,GO:0005782,GO:0005829,GO:0006631,GO:0006637,GO:0016290,GO:0047617,GO:0052689,GO:0102991","very long-chain fatty acid metabolic process|long-chain fatty acid metabolic process|protein binding|mitochondrion|mitochondrial matrix|peroxisomal matrix|cytosol|fatty acid metabolic process|acyl-CoA metabolic process|palmitoyl-CoA hydrolase activity|acyl-CoA hydrolase activity|carboxylic ester hydrolase activity|myristoyl-CoA hydrolase activity","WP4724,WP4718,WP5064,WP4853,WP5329,WP4545,WP4723","Omega-9 fatty acid synthesis|Cholesterol metabolism with Bloch and Kandutsch-Russell pathways|7-oxo-C and 7-beta-HC pathways|Linoleic acid metabolism affected by SARS-CoV-2|Cholesterol biosynthesis pathway in hepatocytes|Oxysterols derived from cholesterol|Omega-3 / omega-6 fatty acid synthesis","R-HSA-1430728,R-HSA-556833,R-HSA-77289,R-HSA-8978868,R-HSA-9033241,R-HSA-9033241,R-HSA-9609507,R-HSA-9609507","Metabolism|Metabolism of lipids|Mitochondrial Fatty Acid Beta-Oxidation|Fatty acid metabolism|Peroxisomal protein import|Peroxisomal protein import|Protein localization|Protein localization"]
["ACOT4",0.533604260629385,0.332530258116981,0.760087526680269,0.829400154567365,0.521415621700451,1.17494994372633,0.995695912745693,1.01041509537346,0.499717445412622,0.567094396602213,1.24590775778393,0.962627983131649,1.11989610049138,0.824487507658722,0.752929483016711,0.750183774830933,0.583790680569265,0.510750236937034,0.493168437867761,0.530819144926561,0.798882471583993,0.664620677094776,0.290639932174303,0.359528795326615,0.492542988585847,0.786755211413021,0.409526137258503,0.622737614517863,122970,"acyl-CoA thioesterase 4","protein_coding","hsa00062,hsa01040,hsa04913","Fatty acid elongation|Biosynthesis of unsaturated fatty acids|Ovarian steroidogenesis","GO:0000038,GO:0001676,GO:0004778,GO:0005777,GO:0005782,GO:0005829,GO:0006104,GO:0006631,GO:0006633,GO:0006637,GO:0016290,GO:0019605,GO:0032788,GO:0032789,GO:0043648,GO:0043649,GO:0044466,GO:0046459,GO:0047617,GO:0052689,GO:0102991","very long-chain fatty acid metabolic process|long-chain fatty acid metabolic process|succinyl-CoA hydrolase activity|peroxisome|peroxisomal matrix|cytosol|succinyl-CoA metabolic process|fatty acid metabolic process|fatty acid biosynthetic process|acyl-CoA metabolic process|palmitoyl-CoA hydrolase activity|butyrate metabolic process|saturated monocarboxylic acid metabolic process|unsaturated monocarboxylic acid metabolic process|dicarboxylic acid metabolic process|dicarboxylic acid catabolic process|glutaryl-CoA hydrolase activity|short-chain fatty acid metabolic process|acyl-CoA hydrolase activity|carboxylic ester hydrolase activity|myristoyl-CoA hydrolase activity","WP5064,WP4545","7-oxo-C and 7-beta-HC pathways|Oxysterols derived from cholesterol","R-HSA-1430728,R-HSA-390247,R-HSA-390918,R-HSA-556833,R-HSA-8978868,R-HSA-9033241,R-HSA-9033241,R-HSA-9609507,R-HSA-9609507","Metabolism|Beta-oxidation of very long chain fatty acids|Peroxisomal lipid metabolism|Metabolism of lipids|Fatty acid metabolism|Peroxisomal protein import|Peroxisomal protein import|Protein localization|Protein localization"]
["ACOT6",0,0,0,0,0,0.0148989169023221,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,641372,"acyl-CoA thioesterase 6","protein_coding",null,null,"GO:0005782,GO:0005829,GO:0006631,GO:0006637,GO:0047617,GO:0052689","peroxisomal matrix|cytosol|fatty acid metabolic process|acyl-CoA metabolic process|acyl-CoA hydrolase activity|carboxylic ester hydrolase activity","WP5064,WP4545","7-oxo-C and 7-beta-HC pathways|Oxysterols derived from cholesterol","R-HSA-1430728,R-HSA-390247,R-HSA-390918,R-HSA-556833,R-HSA-8978868","Metabolism|Beta-oxidation of very long chain fatty acids|Peroxisomal lipid metabolism|Metabolism of lipids|Fatty acid metabolism"]
["ACOT7",32.0582285050895,27.7196306773917,24.4385340403807,32.5098958403131,27.8553389757202,26.0302877775282,23.9409828918046,26.830245564974,25.217461240922,33.0267075454657,27.5159129349851,28.0862763175109,24.1498249258827,23.107446318313,21.0128796887031,21.8728849673008,34.5149061756589,34.6506770723031,38.5357452769051,33.242036357431,34.953642373639,37.4445893276349,31.7627424696062,31.6138838921527,32.2535406917578,40.2886576060951,35.5450575982603,39.6770277541739,11332,"acyl-CoA thioesterase 7","protein_coding","hsa00062,hsa01040","Fatty acid elongation|Biosynthesis of unsaturated fatty acids","GO:0000062,GO:0005515,GO:0005654,GO:0005739,GO:0005829,GO:0006637,GO:0015937,GO:0016290,GO:0036042,GO:0036114,GO:0036116,GO:0042803,GO:0051792,GO:0052689,GO:0070062,GO:0102991,GO:1900535","fatty-acyl-CoA binding|protein binding|nucleoplasm|mitochondrion|cytosol|acyl-CoA metabolic process|coenzyme A biosynthetic process|palmitoyl-CoA hydrolase activity|long-chain fatty acyl-CoA binding|medium-chain fatty-acyl-CoA catabolic process|long-chain fatty-acyl-CoA catabolic process|protein homodimerization activity|medium-chain fatty acid biosynthetic process|carboxylic ester hydrolase activity|extracellular exosome|myristoyl-CoA hydrolase activity|palmitic acid biosynthetic process","WP5064,WP4545","7-oxo-C and 7-beta-HC pathways|Oxysterols derived from cholesterol","R-HSA-1430728,R-HSA-556833,R-HSA-77289,R-HSA-8978868","Metabolism|Metabolism of lipids|Mitochondrial Fatty Acid Beta-Oxidation|Fatty acid metabolism"]
["ACOT8",13.1381390772258,15.0417572305226,14.7438089029514,13.5258002285491,12.0664683286221,14.0469025184906,16.2481894821261,13.5284545240063,14.8698430755169,17.1955283485584,17.3061752086583,14.983409695194,13.7040479582416,16.3104733999553,14.6661546156041,15.0772785937196,17.9456221694383,16.7630527316283,18.1226013512467,15.7765726984926,17.638043007424,18.3467298383492,18.6217072084217,18.6212659234493,17.5049953293555,20.840726601936,21.7976650314135,20.929284521013,10005,"acyl-CoA thioesterase 8","protein_coding","hsa00120,hsa04146","Primary bile acid biosynthesis|Peroxisome","GO:0003986,GO:0004778,GO:0005515,GO:0005782,GO:0005829,GO:0006637,GO:0006699,GO:0009062,GO:0016289,GO:0016290,GO:0016559,GO:0033540,GO:0033882,GO:0036109,GO:0043649,GO:0044466,GO:0045225,GO:0047603,GO:0047617,GO:0047994,GO:0052689,GO:0052815,GO:0052816,GO:0102991","acetyl-CoA hydrolase activity|succinyl-CoA hydrolase activity|protein binding|peroxisomal matrix|cytosol|acyl-CoA metabolic process|bile acid biosynthetic process|fatty acid catabolic process|CoA hydrolase activity|palmitoyl-CoA hydrolase activity|peroxisome fission|fatty acid beta-oxidation using acyl-CoA oxidase|choloyl-CoA hydrolase activity|alpha-linolenic acid metabolic process|dicarboxylic acid catabolic process|glutaryl-CoA hydrolase activity|negative regulation of CD4 production|acetoacetyl-CoA hydrolase activity|acyl-CoA hydrolase activity|hydroxymethylglutaryl-CoA hydrolase activity|carboxylic ester hydrolase activity|medium-chain acyl-CoA hydrolase activity|long-chain acyl-CoA hydrolase activity|myristoyl-CoA hydrolase activity","WP5064,WP5329,WP4545","7-oxo-C and 7-beta-HC pathways|Cholesterol biosynthesis pathway in hepatocytes|Oxysterols derived from cholesterol","R-HSA-1430728,R-HSA-192105,R-HSA-193368,R-HSA-194068,R-HSA-2046104,R-HSA-2046106,R-HSA-389887,R-HSA-390247,R-HSA-390918,R-HSA-556833,R-HSA-8957322,R-HSA-8978868,R-HSA-9033241,R-HSA-9033241,R-HSA-9609507,R-HSA-9609507","Metabolism|Synthesis of bile acids and bile salts|Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol|Bile acid and bile salt metabolism|alpha-linolenic (omega3) and linoleic (omega6) acid metabolism|alpha-linolenic acid (ALA) metabolism|Beta-oxidation of pristanoyl-CoA|Beta-oxidation of very long chain fatty acids|Peroxisomal lipid metabolism|Metabolism of lipids|Metabolism of steroids|Fatty acid metabolism|Peroxisomal protein import|Peroxisomal protein import|Protein localization|Protein localization"]
["ACOT9",14.4707056311471,13.1880660552156,13.046411598287,14.2195173238094,14.1645650349545,13.0962997756552,13.751488329683,13.3573877056328,14.8758158808721,12.0672340716306,12.3055111592354,14.0939581600543,13.9396168813407,13.9210319533577,13.8640761820251,14.3300922915337,16.2835089933833,16.6354593151515,15.6185430540661,15.6382458951818,16.4923653040692,15.3749124559768,16.6954947200841,17.5956165084277,15.9372210777154,16.4249878508048,17.2953806097091,17.0844023206287,23597,"acyl-CoA thioesterase 9","protein_coding",null,null,"GO:0003986,GO:0005739,GO:0005759,GO:0006637,GO:0016290,GO:0047617,GO:0052689","acetyl-CoA hydrolase activity|mitochondrion|mitochondrial matrix|acyl-CoA metabolic process|palmitoyl-CoA hydrolase activity|acyl-CoA hydrolase activity|carboxylic ester hydrolase activity","WP5064,WP4545,WP3888","7-oxo-C and 7-beta-HC pathways|Oxysterols derived from cholesterol|VEGFA-VEGFR2 signaling","R-HSA-1430728,R-HSA-556833,R-HSA-77289,R-HSA-8978868","Metabolism|Metabolism of lipids|Mitochondrial Fatty Acid Beta-Oxidation|Fatty acid metabolism"]
["ACOX1",5.86126683904895,5.83527235160271,5.72669777616989,5.13014748355546,5.86791148217291,5.70165943309115,5.07252483312158,5.14905288070222,6.5271896018196,4.74652152686341,5.29776497042663,5.45227026354975,6.09105168238348,5.62478550989656,5.93699615711675,6.07619232101983,5.07543734266331,5.47515171038481,4.61637434474776,5.70377892003359,5.20440823288876,5.21126289527868,5.32580657105705,5.57551501460462,5.01811328058766,5.22597016190581,4.86400185920032,4.80788282542369,51,"acyl-CoA oxidase 1","protein_coding","hsa00640,hsa00071,hsa00592,hsa01040,hsa00410,hsa04024,hsa04146,hsa03320,hsa04936","Propanoate metabolism|Fatty acid degradation|alpha-Linolenic acid metabolism|Biosynthesis of unsaturated fatty acids|beta-Alanine metabolism|cAMP signaling pathway|Peroxisome|PPAR signaling pathway|Alcoholic liver disease","GO:0000038,GO:0003997,GO:0005504,GO:0005515,GO:0005777,GO:0005778,GO:0005782,GO:0005829,GO:0006091,GO:0006629,GO:0006693,GO:0007283,GO:0009062,GO:0016020,GO:0016401,GO:0019395,GO:0030165,GO:0033540,GO:0042803,GO:0050660,GO:0050665,GO:0055088,GO:0071949,GO:0140493","very long-chain fatty acid metabolic process|acyl-CoA oxidase activity|fatty acid binding|protein binding|peroxisome|peroxisomal membrane|peroxisomal matrix|cytosol|generation of precursor metabolites and energy|lipid metabolic process|prostaglandin metabolic process|spermatogenesis|fatty acid catabolic process|membrane|palmitoyl-CoA oxidase activity|fatty acid oxidation|PDZ domain binding|fatty acid beta-oxidation using acyl-CoA oxidase|protein homodimerization activity|flavin adenine dinucleotide binding|hydrogen peroxide biosynthetic process|lipid homeostasis|FAD binding|very long-chain fatty acid beta-oxidation","WP5323,WP2881,WP1941,WP2882,WP4719,WP3942,WP4723,WP4721","Fatty Acids and Lipoproteins Transport in Hepatocytes|Estrogen receptor pathway|Peroxisomal beta-oxidation of tetracosanoyl-CoA|Nuclear receptors meta-pathway|Eicosanoid metabolism via cyclooxygenases (COX)|PPAR signaling pathway|Omega-3 / omega-6 fatty acid synthesis|Eicosanoid metabolism via lipooxygenases (LOX)","R-HSA-1430728,R-HSA-1989781,R-HSA-2046104,R-HSA-2046106,R-HSA-390247,R-HSA-390918,R-HSA-400206,R-HSA-556833,R-HSA-8978868,R-HSA-9033241,R-HSA-9033241,R-HSA-9033500,R-HSA-9609507,R-HSA-9609507","Metabolism|PPARA activates gene expression|alpha-linolenic (omega3) and linoleic (omega6) acid metabolism|alpha-linolenic acid (ALA) metabolism|Beta-oxidation of very long chain fatty acids|Peroxisomal lipid metabolism|Regulation of lipid metabolism by PPARalpha|Metabolism of lipids|Fatty acid metabolism|Peroxisomal protein import|Peroxisomal protein import|TYSND1 cleaves peroxisomal proteins|Protein localization|Protein localization"]
["ACOX2",6.21810721503757,6.61026946079995,5.07814158356626,6.60133706274478,7.70069097092665,8.04570305862503,4.00206142390777,7.36911861035594,6.91236226346681,8.34807197753127,5.82692268378099,6.92501618700788,7.10447039850301,7.85143590468383,6.22605022374184,8.56506916074207,4.89136371472031,4.31761060696916,2.52003421794411,4.2527736962671,5.6911235568648,4.75161065904903,2.95442601694967,4.30983665072141,4.93401848420659,4.91833435365748,3.09974298525442,5.48103273907301,8309,"acyl-CoA oxidase 2","protein_coding","hsa00120,hsa04146,hsa03320","Primary bile acid biosynthesis|Peroxisome|PPAR signaling pathway","GO:0000038,GO:0005504,GO:0005515,GO:0005777,GO:0005782,GO:0005829,GO:0006699,GO:0016401,GO:0033540,GO:0033791,GO:0042803,GO:0043231,GO:0050660,GO:0055088,GO:0071949","very long-chain fatty acid metabolic process|fatty acid binding|protein binding|peroxisome|peroxisomal matrix|cytosol|bile acid biosynthetic process|palmitoyl-CoA oxidase activity|fatty acid beta-oxidation using acyl-CoA oxidase|3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase activity|protein homodimerization activity|intracellular membrane-bounded organelle|flavin adenine dinucleotide binding|lipid homeostasis|FAD binding","WP5323,WP5064,WP2435,WP4719,WP4545,WP5176,WP3942,WP4721","Fatty Acids and Lipoproteins Transport in Hepatocytes|7-oxo-C and 7-beta-HC pathways|Quercetin and Nf-kB / AP-1 induced apoptosis|Eicosanoid metabolism via cyclooxygenases (COX)|Oxysterols derived from cholesterol|Disorders of bile acid synthesis and biliary transport|PPAR signaling pathway|Eicosanoid metabolism via lipooxygenases (LOX)","R-HSA-1430728,R-HSA-192105,R-HSA-193368,R-HSA-194068,R-HSA-389887,R-HSA-390918,R-HSA-556833,R-HSA-8957322,R-HSA-8978868,R-HSA-9033241,R-HSA-9033241,R-HSA-9609507,R-HSA-9609507","Metabolism|Synthesis of bile acids and bile salts|Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol|Bile acid and bile salt metabolism|Beta-oxidation of pristanoyl-CoA|Peroxisomal lipid metabolism|Metabolism of lipids|Metabolism of steroids|Fatty acid metabolism|Peroxisomal protein import|Peroxisomal protein import|Protein localization|Protein localization"]
["ACOX3",4.90259773992942,5.39516551114323,5.21912674487718,5.74960537524152,5.1534576250703,5.40225089726921,5.44772356553754,5.63598261173895,4.63362736145489,5.65997625396966,5.67342867238147,5.3872212529425,4.73909416477093,5.33588122939912,4.90472086048337,5.34235183155576,5.13782206334498,6.43831824427226,5.83420764149817,6.07029683571787,5.93272880457265,6.19982548169055,4.65930872001904,5.44690790396304,5.5061326174602,6.05943397836467,5.38469266607544,6.25327692438098,8310,"acyl-CoA oxidase 3%2C pristanoyl","protein_coding","hsa00640,hsa00071,hsa00592,hsa01040,hsa00410,hsa04024,hsa04146,hsa03320,hsa04936","Propanoate metabolism|Fatty acid degradation|alpha-Linolenic acid metabolism|Biosynthesis of unsaturated fatty acids|beta-Alanine metabolism|cAMP signaling pathway|Peroxisome|PPAR signaling pathway|Alcoholic liver disease","GO:0005504,GO:0005777,GO:0005782,GO:0005829,GO:0016020,GO:0016402,GO:0033540,GO:0050660,GO:0055088,GO:0071949","fatty acid binding|peroxisome|peroxisomal matrix|cytosol|membrane|pristanoyl-CoA oxidase activity|fatty acid beta-oxidation using acyl-CoA oxidase|flavin adenine dinucleotide binding|lipid homeostasis|FAD binding","WP5323,WP4719,WP3942,WP4723,WP4721","Fatty Acids and Lipoproteins Transport in Hepatocytes|Eicosanoid metabolism via cyclooxygenases (COX)|PPAR signaling pathway|Omega-3 / omega-6 fatty acid synthesis|Eicosanoid metabolism via lipooxygenases (LOX)","R-HSA-1430728,R-HSA-389887,R-HSA-390918,R-HSA-556833,R-HSA-8978868,R-HSA-9033241,R-HSA-9033241,R-HSA-9609507,R-HSA-9609507","Metabolism|Beta-oxidation of pristanoyl-CoA|Peroxisomal lipid metabolism|Metabolism of lipids|Fatty acid metabolism|Peroxisomal protein import|Peroxisomal protein import|Protein localization|Protein localization"]
["ACOXL",0,0.00301538669411649,0,0.003040406831234,0,0.00148848993396715,0.00147888423981438,0,0.0159439600300001,0.00915992838213986,0.0223604275103084,0.0159474257421347,0.0150741630455783,0.00755599524773502,0.00589653754621087,0.00300583167671961,1.52397789556266E-3,0,0.00292996695477162,0.00914559622859476,0.00448829883904357,0,0.00469452877626302,0.00154859956825088,0,0,0.00153387242120097,0.0014901776583243,55289,"acyl-CoA oxidase like","protein_coding",null,null,"GO:0003674,GO:0003997,GO:0005504,GO:0005575,GO:0005777,GO:0005782,GO:0008150,GO:0033540,GO:0050660,GO:0055088,GO:0071949","molecular_function|acyl-CoA oxidase activity|fatty acid binding|cellular_component|peroxisome|peroxisomal matrix|biological_process|fatty acid beta-oxidation using acyl-CoA oxidase|flavin adenine dinucleotide binding|lipid homeostasis|FAD binding","WP5323,WP5222","Fatty Acids and Lipoproteins Transport in Hepatocytes|2q13 copy number variation syndrome","R-HSA-1430728,R-HSA-389887,R-HSA-390918,R-HSA-556833,R-HSA-8978868","Metabolism|Beta-oxidation of pristanoyl-CoA|Peroxisomal lipid metabolism|Metabolism of lipids|Fatty acid metabolism"]
["ACOXL-AS1",0.00839234596364978,0.0159650268120003,0,0,0.00820064720435394,0,7.82998299572959E-3,0.00822950828768301,0,0.00808290483949099,7.89251619427782E-3,8.44339732785627E-3,0,0.0320042976794475,0.0312193392001438,0.0238716563640849,0,0,0,0.0322810314370034,0.0316845205715131,0.0239317024630623,0,0,0,0,0,0,400997,"ACOXL antisense RNA 1","non_coding"]
["ACP1",41.4423807633239,35.8389467094532,43.1839201446324,38.8146758254921,38.0587084562679,35.2843001106294,44.322354028279,39.8035373547162,41.12961168597,29.0691350615642,34.985456056458,37.7128434708347,37.323600976574,38.2145853641133,38.1522982828723,36.1784981379281,48.9905887699138,43.7204089245569,54.6026823650802,47.4632208011828,48.4045035152291,46.6889969558727,61.0079182004535,54.6406584736794,51.7917517803914,47.6647738537979,61.4046045119757,53.9832914321027,52,"acid phosphatase 1","protein_coding","hsa00730,hsa00740,hsa04520,hsa05208","Thiamine metabolism|Riboflavin metabolism|Adherens junction|Chemical carcinogenesis - reactive oxygen species","GO:0003993,GO:0004725,GO:0004726,GO:0005515,GO:0005737,GO:0005829,GO:0009898,GO:0042383,GO:0070062","acid phosphatase activity|protein tyrosine phosphatase activity|non-membrane spanning protein tyrosine phosphatase activity|protein binding|cytoplasm|cytosol|cytoplasmic side of plasma membrane|sarcolemma|extracellular exosome","WP3888","VEGFA-VEGFR2 signaling"]
["ACP2",16.6365778652902,16.565376155763,16.6831917832678,18.7637861922354,14.8258936855867,17.4077170007714,17.5707836551651,17.1010984563275,16.8410316117003,23.1420327862224,21.9417896380447,20.6341541309935,15.8212380378942,17.774609367843,14.5495385131288,15.5948801308697,15.007432070759,20.0909634923398,16.9472971977683,17.8034059599022,15.1006648601153,17.1941507625927,11.9245678150998,13.0696906105761,15.6042262868047,18.7695892503692,12.0199107242579,18.7594894985162,53,"acid phosphatase 2%2C lysosomal","protein_coding","hsa00740,hsa04142","Riboflavin metabolism|Lysosome","GO:0003993,GO:0005515,GO:0005764,GO:0005765,GO:0007040,GO:0016020,GO:0016311,GO:0043202,GO:0070062","acid phosphatase activity|protein binding|lysosome|lysosomal membrane|lysosome organization|membrane|dephosphorylation|lysosomal lumen|extracellular exosome"]
["ACP3",0.0755605192298335,0.0539029426630817,0.0532041899687804,0.0362334678149723,0.0861403184969371,0.0532163836377968,0.0234990940268941,0.0679198754544303,0.0443354564328725,0.0849035423551112,0.0710602999748293,0.114030240576346,0.0718573838130639,0.0960502725030464,0.0468472401358851,0.0895535625338013,0.45404288878659,0.180609842018963,0.448105628186073,0.187706544162888,0.23178325875685,0.317218508175806,0.35432561808303,0.159944543494403,0.224737359893565,0.352997413369069,0.463084002339577,0.195347984465377,55,"acid phosphatase 3","protein_coding",null,null,"GO:0003993,GO:0004725,GO:0005515,GO:0005615,GO:0005634,GO:0005764,GO:0005765,GO:0005771,GO:0005829,GO:0005886,GO:0006144,GO:0006629,GO:0006772,GO:0007040,GO:0008253,GO:0009117,GO:0012506,GO:0016311,GO:0016791,GO:0030175,GO:0031985,GO:0033265,GO:0035577,GO:0042131,GO:0042802,GO:0042803,GO:0045177,GO:0046085,GO:0051930,GO:0052642,GO:0060090,GO:0060168,GO:0070062,GO:0106411","acid phosphatase activity|protein tyrosine phosphatase activity|protein binding|extracellular space|nucleus|lysosome|lysosomal membrane|multivesicular body|cytosol|plasma membrane|purine nucleobase metabolic process|lipid metabolic process|thiamine metabolic process|lysosome organization|5'-nucleotidase activity|nucleotide metabolic process|vesicle membrane|dephosphorylation|phosphatase activity|filopodium|Golgi cisterna|choline binding|azurophil granule membrane|thiamine phosphate phosphatase activity|identical protein binding|protein homodimerization activity|apical part of cell|adenosine metabolic process|regulation of sensory perception of pain|lysophosphatidic acid phosphatase activity|molecular adaptor activity|positive regulation of adenosine receptor signaling pathway|extracellular exosome|XMP 5'-nucleosidase activity",null,null,"R-HSA-168249,R-HSA-168256,R-HSA-6798695","Innate Immune System|Immune System|Neutrophil degranulation"]
["ACP4",0,0,0,0,0,0,0,0,0,0,0.0188902846617141,0.0202087870470002,0,0.0191501125458989,0.0186804242754959,0,0,0,0,0,0,0.0190930522382902,0.0198298947762367,0.0981202841195029,0,0.0190858815154839,0,0,93650,"acid phosphatase 4","protein_coding",null,null,"GO:0003993,GO:0004725,GO:0005764,GO:0007040,GO:0010955,GO:0010977,GO:0030971,GO:0042476,GO:0045211,GO:0048168,GO:0120154,GO:1990264","acid phosphatase activity|protein tyrosine phosphatase activity|lysosome|lysosome organization|negative regulation of protein processing|negative regulation of neuron projection development|receptor tyrosine kinase binding|odontogenesis|postsynaptic membrane|regulation of neuronal synaptic plasticity|negative regulation of ERBB4 signaling pathway|peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity"]
["ACP5",3.11933059617085,2.50958828890777,1.85474150128388,3.56501334416156,3.40368771642388,3.61269281863328,2.15847789684014,3.86174239530928,1.13738860325486,1.58978344925001,1.25898191304247,1.52992405467584,1.13714136650365,1.36303742238457,0.737327334638691,1.07212972372313,0.437361081590092,0.493060317930295,0.384393581738447,0.512434135969365,0.588837107477531,0.420047149242384,0.30794660123097,0.558708441339287,0.644286830135242,0.543386273734954,0.440200676867421,0.574287453761216,54,"acid phosphatase 5%2C tartrate resistant","protein_coding","hsa00740,hsa04142,hsa04380,hsa05323","Riboflavin metabolism|Lysosome|Osteoclast differentiation|Rheumatoid arthritis","GO:0003993,GO:0005764,GO:0005829,GO:0006809,GO:0008198,GO:0008199,GO:0010936,GO:0016020,GO:0016311,GO:0032496,GO:0032691,GO:0032695,GO:0032720,GO:0032929,GO:0034097,GO:0042554,GO:0045019,GO:0045453,GO:0050728,GO:0050830,GO:0060349","acid phosphatase activity|lysosome|cytosol|nitric oxide biosynthetic process|ferrous iron binding|ferric iron binding|negative regulation of macrophage cytokine production|membrane|dephosphorylation|response to lipopolysaccharide|negative regulation of interleukin-1 beta production|negative regulation of interleukin-12 production|negative regulation of tumor necrosis factor production|negative regulation of superoxide anion generation|response to cytokine|superoxide anion generation|negative regulation of nitric oxide biosynthetic process|bone resorption|negative regulation of inflammatory response|defense response to Gram-positive bacterium|bone morphogenesis","WP12,WP2018","Osteoclast signaling|RANKL/RANK signaling pathway","R-HSA-1430728,R-HSA-196843,R-HSA-196849,R-HSA-196854","Metabolism|Vitamin B2 (riboflavin) metabolism|Metabolism of water-soluble vitamins and cofactors|Metabolism of vitamins and cofactors"]
["ACP6",0.547334319497322,0.680792131231914,0.859722371525982,0.74297143125667,0.734365555554657,0.735379355871993,0.927040635723373,0.699792911377807,0.747469531022055,0.806949750651241,0.791901976291147,0.756103758023861,0.616604254275334,0.832899037890471,0.888823485941651,0.736518431057962,0.60111519900865,0.588236957771839,0.745167821420543,0.787468094250875,0.560314950826775,0.708355965696216,0.660876733707745,0.695149838273644,0.684561172213606,0.698088660275598,0.778171272070951,0.74610850402683,51205,"acid phosphatase 6%2C lysophosphatidic","protein_coding",null,null,"GO:0002244,GO:0003993,GO:0005737,GO:0005739,GO:0005759,GO:0006644,GO:0006654,GO:0016311,GO:0052642,GO:2001311","hematopoietic progenitor cell differentiation|acid phosphatase activity|cytoplasm|mitochondrion|mitochondrial matrix|phospholipid metabolic process|phosphatidic acid biosynthetic process|dephosphorylation|lysophosphatidic acid phosphatase activity|lysobisphosphatidic acid metabolic process","WP4905","1q21.1 copy number variation syndrome","R-HSA-1430728,R-HSA-1483166,R-HSA-1483206,R-HSA-1483257,R-HSA-556833","Metabolism|Synthesis of PA|Glycerophospholipid biosynthesis|Phospholipid metabolism|Metabolism of lipids"]
["ACP7",0.351144792469515,0.205964790104794,0.225272654689784,0.207673780629909,0.217311809634091,0.236315712577714,0.141966465466645,0.218076609544385,0.105961218342667,0.0394563683046277,0.0440308502232225,0.0117760278840965,0.0166967792066721,0.0781138329379828,0.032656269271883,0.0221959068581388,0.0787743711001173,0.18952611375703,0.0378624757088497,0.0675336558677736,0.0552381025161203,0.0723181479264461,0.0635538225546692,0.0571764747235662,0.0870332752301667,0.16126451081624,0.0453061821883522,0.126544747920462,390928,"acid phosphatase 7%2C tartrate resistant (putative)","protein_coding",null,null,"GO:0003993,GO:0005576,GO:0046872","acid phosphatase activity|extracellular region|metal ion binding"]
["ACR",0,0,0.0530925727870277,0.0542361803202436,0.0552597457770311,0,0.0175873464211772,0,0.0189610478510616,0.0181554477933182,0,0.0948258469128474,0.0358533170284064,0.0179716440815359,0.0876542985234808,0.0178731375854174,0,0,0,0,0.0711683077452448,0.0179180951774723,0,0,0,0,0,0,49,"acrosin","protein_coding",null,null,"GO:0002020,GO:0002077,GO:0003677,GO:0004040,GO:0004252,GO:0005507,GO:0005515,GO:0005537,GO:0005576,GO:0005634,GO:0005798,GO:0007190,GO:0007338,GO:0007339,GO:0007340,GO:0007341,GO:0008236,GO:0008270,GO:0032991,GO:0042806,GO:0043159,GO:0048545","protease binding|acrosome matrix dispersal|DNA binding|amidase activity|serine-type endopeptidase activity|copper ion binding|protein binding|mannose binding|extracellular region|nucleus|Golgi-associated vesicle|activation of adenylate cyclase activity|single fertilization|binding of sperm to zona pellucida|acrosome reaction|penetration of zona pellucida|serine-type peptidase activity|zinc ion binding|protein-containing complex|fucose binding|acrosomal matrix|response to steroid hormone",null,null,"R-HSA-1187000,R-HSA-1300645,R-HSA-1474165","Fertilization|Acrosome Reaction and Sperm:Oocyte Membrane Binding|Reproduction"]
["ACRBP",0.0283004884359507,0.134592299527939,0.119562801709369,0.0949963543316952,0.0553080920113067,0.345482811151275,0.0792123004166408,0.0416270560945477,0.0853993651244667,0.0408854966054253,0.0399224598677486,0.0427089641213769,0.0807405407096396,0.0944336783496978,0.0394789439019142,0.0939160667874164,0.108836821383469,0.013092722609147,0.026155914977872,0.122464574380695,0.0534229291735958,0.0538013146536177,0.0977858433217678,0.055297604740524,0.0140288806897689,0.107562217296711,0.0684646572045769,0.0931200676127251,84519,"acrosin binding protein","protein_coding",null,null,"GO:0001669,GO:0001675,GO:0002080,GO:0003674,GO:0005576,GO:0005634,GO:0007286,GO:0008150,GO:0009566","acrosomal vesicle|acrosome assembly|acrosomal membrane|molecular_function|extracellular region|nucleus|spermatid development|biological_process|fertilization"]
["ACRV1",0,0,0,0,0.0136056192254054,0.0392250926917025,0,0,0.0840319166126597,0,0.0130944018677791,0.0140083637484888,0.0132412818570819,0,0,0,0.0267735207561349,0.0128830767409221,0.0514741921826924,0.0401678743449077,0.0131418750097753,0.0132349566651784,0.0412371675460377,0.0136030393892947,0.0138042446869885,0.0132299860505059,0.0134736747907767,0.0130898560214168,56,"acrosomal vesicle protein 1","protein_coding",null,null,"GO:0001669,GO:0005515,GO:0007283","acrosomal vesicle|protein binding|spermatogenesis"]
["ACSBG1",0.163123844086191,0.0221654057143484,0.0464909028331043,0.0642543033907071,0.0426958269187132,0.0273538575935221,0.0298950679927726,0.0656973367474465,0.0996202881476787,0.0252496880376059,0.00821831489605155,0.0527516165882146,0.0443226655289571,0.0305482992654592,0.0460530796867477,0.0193332728798388,0.0336072203483102,0.0188665934723337,0.026921881366353,0.0224090497029727,0.00549874000841258,0.0387638065110218,0.0517625824740408,0.0967588572250849,0.109741806044129,0.0221424274854371,0.101476252238813,0.00547697455315821,23205,"acyl-CoA synthetase bubblegum family member 1","protein_coding","hsa00061,hsa00071,hsa04920,hsa03320","Fatty acid biosynthesis|Fatty acid degradation|Adipocytokine signaling pathway|PPAR signaling pathway","GO:0000038,GO:0001676,GO:0004467,GO:0005524,GO:0005737,GO:0005783,GO:0005829,GO:0005886,GO:0031410,GO:0031957,GO:0035338,GO:0042552,GO:0042759,GO:0051384","very long-chain fatty acid metabolic process|long-chain fatty acid metabolic process|long-chain fatty acid-CoA ligase activity|ATP binding|cytoplasm|endoplasmic reticulum|cytosol|plasma membrane|cytoplasmic vesicle|very long-chain fatty acid-CoA ligase activity|long-chain fatty-acyl-CoA biosynthetic process|myelination|long-chain fatty acid biosynthetic process|response to glucocorticoid","WP5061,WP3965,WP3942","Fatty acid transporters|Lipid metabolism pathway|PPAR signaling pathway","R-HSA-1430728,R-HSA-556833,R-HSA-75105,R-HSA-75876,R-HSA-8978868","Metabolism|Metabolism of lipids|Fatty acyl-CoA biosynthesis|Synthesis of very long-chain fatty acyl-CoAs|Fatty acid metabolism"]
["ACSBG2",0,0,0,0,0.00870471871129704,0,0,0,0.00896044230899478,0,0,0,0,0,0,0,0.00856469533771929,0,0,0,0,0,0,0,0,0,0,0,81616,"acyl-CoA synthetase bubblegum family member 2","protein_coding","hsa00061,hsa00071,hsa04920,hsa03320","Fatty acid biosynthesis|Fatty acid degradation|Adipocytokine signaling pathway|PPAR signaling pathway","GO:0004467,GO:0005524,GO:0005737,GO:0005739,GO:0005829,GO:0006631,GO:0007283,GO:0016020,GO:0030154,GO:0031957,GO:0035338,GO:0042759,GO:0047617,GO:0047676","long-chain fatty acid-CoA ligase activity|ATP binding|cytoplasm|mitochondrion|cytosol|fatty acid metabolic process|spermatogenesis|membrane|cell differentiation|very long-chain fatty acid-CoA ligase activity|long-chain fatty-acyl-CoA biosynthetic process|long-chain fatty acid biosynthetic process|acyl-CoA hydrolase activity|arachidonate-CoA ligase activity","WP5061,WP3942","Fatty acid transporters|PPAR signaling pathway","R-HSA-1430728,R-HSA-556833,R-HSA-75105,R-HSA-75876,R-HSA-8978868","Metabolism|Metabolism of lipids|Fatty acyl-CoA biosynthesis|Synthesis of very long-chain fatty acyl-CoAs|Fatty acid metabolism"]
["ACSF2",8.28365867161121,8.10767216882599,8.17443838200724,8.62484181612159,8.73171220658767,10.1210062596166,7.98477471389984,9.95171103988691,7.45758292899312,9.3226220846352,9.54419605611632,9.08227150223755,8.23675174372245,9.26096516556464,7.88464553008794,8.65694067242072,7.57922462451005,7.16701526238449,8.12121176766255,7.76769854847331,7.25699246719762,7.52590418668062,7.11603685802932,7.70167599895492,7.32782743771238,7.88183719036082,7.07484591611591,8.74491277687498,80221,"acyl-CoA synthetase family member 2","protein_coding",null,null,"GO:0001676,GO:0004467,GO:0005515,GO:0005524,GO:0005759,GO:0006631,GO:0006637,GO:0031956,GO:0047760","long-chain fatty acid metabolic process|long-chain fatty acid-CoA ligase activity|protein binding|ATP binding|mitochondrial matrix|fatty acid metabolic process|acyl-CoA metabolic process|medium-chain fatty acid-CoA ligase activity|butyrate-CoA ligase activity","WP368,WP5123","Mitochondrial long chain fatty acid beta-oxidation|Mitochondrial fatty acid oxidation disorders","R-HSA-1430728,R-HSA-556833,R-HSA-77289,R-HSA-8978868","Metabolism|Metabolism of lipids|Mitochondrial Fatty Acid Beta-Oxidation|Fatty acid metabolism"]
["ACSF3",1.26722966685154,1.41842787705189,1.50833966553206,1.5809131218047,1.35427046279453,1.39408178600448,1.32269410593998,1.43116885892415,1.37555793309978,1.67457094754545,1.83008477962339,1.48686739766148,1.31641532790605,1.56357984786039,1.22360486357368,1.23639901158363,1.17014432962858,1.41228691322241,1.6532780108889,1.50314809030385,1.22921359121449,1.44768296517914,1.22297715350873,1.21028242588296,1.25801838532209,1.6917709277087,1.19230155972919,1.48367721576811,197322,"acyl-CoA synthetase family member 3","protein_coding","hsa00061,hsa00280","Fatty acid biosynthesis|Valine, leucine and isoleucine degradation","GO:0005515,GO:0005524,GO:0005654,GO:0005739,GO:0005759,GO:0006631,GO:0006633,GO:0016878,GO:0031957,GO:0035338,GO:0090409,GO:0090410","protein binding|ATP binding|nucleoplasm|mitochondrion|mitochondrial matrix|fatty acid metabolic process|fatty acid biosynthetic process|acid-thiol ligase activity|very long-chain fatty acid-CoA ligase activity|long-chain fatty-acyl-CoA biosynthetic process|malonyl-CoA synthetase activity|malonate catabolic process","WP4686","Leucine, isoleucine and valine metabolism","R-HSA-1430728,R-HSA-556833,R-HSA-75105,R-HSA-75876,R-HSA-8978868","Metabolism|Metabolism of lipids|Fatty acyl-CoA biosynthesis|Synthesis of very long-chain fatty acyl-CoAs|Fatty acid metabolism"]
["ACSL1",12.4723647143609,11.8687702747609,11.5417600020856,10.8119831266586,12.5704401811201,13.5469508920386,11.4967923257049,11.9025611258925,11.8266343363517,9.71989959228636,8.55323978218518,10.2055886897692,11.9652492232634,10.5061685657413,11.6849908153559,12.3065934048695,9.83030716166326,8.83116317310757,7.31904241791006,10.0594030067785,9.16088439424198,9.7571824547449,8.89333257821599,9.70758496049411,9.82831525937502,8.24750032256401,8.66154766203714,8.00842821007705,2180,"acyl-CoA synthetase long chain family member 1","protein_coding","hsa00061,hsa00071,hsa04146,hsa04216,hsa04920,hsa03320,hsa04714","Fatty acid biosynthesis|Fatty acid degradation|Peroxisome|Ferroptosis|Adipocytokine signaling pathway|PPAR signaling pathway|Thermogenesis","GO:0000038,GO:0001676,GO:0004467,GO:0005524,GO:0005739,GO:0005741,GO:0005778,GO:0005783,GO:0005789,GO:0007584,GO:0008610,GO:0010747,GO:0014070,GO:0015908,GO:0016020,GO:0019432,GO:0033211,GO:0034201,GO:0035338,GO:0042178,GO:0043539,GO:0044539,GO:0047676,GO:0050197,GO:0070251,GO:0090434,GO:0120162","very long-chain fatty acid metabolic process|long-chain fatty acid metabolic process|long-chain fatty acid-CoA ligase activity|ATP binding|mitochondrion|mitochondrial outer membrane|peroxisomal membrane|endoplasmic reticulum|endoplasmic reticulum membrane|response to nutrient|lipid biosynthetic process|positive regulation of long-chain fatty acid import across plasma membrane|response to organic cyclic compound|fatty acid transport|membrane|triglyceride biosynthetic process|adiponectin-activated signaling pathway|response to oleic acid|long-chain fatty-acyl-CoA biosynthetic process|xenobiotic catabolic process|protein serine/threonine kinase activator activity|long-chain fatty acid import into cell|arachidonate-CoA ligase activity|phytanate-CoA ligase activity|pristanate-CoA ligase activity|oleoyl-CoA ligase activity|positive regulation of cold-induced thermogenesis","WP368,WP4321,WP4724,WP5323,WP5061,WP4718,WP4313,WP5181,WP357,WP5123,WP5329,WP143,WP3942,WP4723,WP5315","Mitochondrial long chain fatty acid beta-oxidation|Thermogenesis|Omega-9 fatty acid synthesis|Fatty Acids and Lipoproteins Transport in Hepatocytes|Fatty acid transporters|Cholesterol metabolism with Bloch and Kandutsch-Russell pathways|Ferroptosis|Roles of ceramides in development of insulin resistance|Fatty acid biosynthesis|Mitochondrial fatty acid oxidation disorders|Cholesterol biosynthesis pathway in hepatocytes|Fatty acid beta-oxidation|PPAR signaling pathway|Omega-3 / omega-6 fatty acid synthesis|Sebaleic acid formation and metabolism","R-HSA-1430728,R-HSA-1989781,R-HSA-2046104,R-HSA-2046105,R-HSA-2046106,R-HSA-400206,R-HSA-556833,R-HSA-75105,R-HSA-75876,R-HSA-8978868","Metabolism|PPARA activates gene expression|alpha-linolenic (omega3) and linoleic (omega6) acid metabolism|Linoleic acid (LA) metabolism|alpha-linolenic acid (ALA) metabolism|Regulation of lipid metabolism by PPARalpha|Metabolism of lipids|Fatty acyl-CoA biosynthesis|Synthesis of very long-chain fatty acyl-CoAs|Fatty acid metabolism"]
["ACSL3",29.5372837193062,31.7681991115476,34.4874831778983,27.368410992369,33.6045377097074,31.6359011878799,36.0901367714568,32.2155869955885,32.3699119467612,22.0658519334175,23.7598051026965,27.368198278231,36.0050041389111,30.7130789239581,37.300275340915,36.9057376859914,29.6669620761943,26.6142512516766,30.9218772479255,32.591489640725,28.1206057013903,27.9292565599626,34.952634056773,29.895992618852,30.0937979637765,25.5168071783106,30.3693972254563,24.9375440883911,2181,"acyl-CoA synthetase long chain family member 3","protein_coding","hsa00061,hsa00071,hsa04146,hsa04216,hsa04920,hsa03320,hsa04714","Fatty acid biosynthesis|Fatty acid degradation|Peroxisome|Ferroptosis|Adipocytokine signaling pathway|PPAR signaling pathway|Thermogenesis","GO:0001676,GO:0004467,GO:0005515,GO:0005524,GO:0005741,GO:0005778,GO:0005783,GO:0005789,GO:0005794,GO:0005811,GO:0005886,GO:0006631,GO:0016020,GO:0019901,GO:0019904,GO:0030182,GO:0031956,GO:0034379,GO:0035336,GO:0035338,GO:0042998,GO:0044539,GO:0047676,GO:0048471,GO:0051047,GO:0090433,GO:2001247","long-chain fatty acid metabolic process|long-chain fatty acid-CoA ligase activity|protein binding|ATP binding|mitochondrial outer membrane|peroxisomal membrane|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|lipid droplet|plasma membrane|fatty acid metabolic process|membrane|protein kinase binding|protein domain specific binding|neuron differentiation|medium-chain fatty acid-CoA ligase activity|very-low-density lipoprotein particle assembly|long-chain fatty-acyl-CoA metabolic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of Golgi to plasma membrane protein transport|long-chain fatty acid import into cell|arachidonate-CoA ligase activity|perinuclear region of cytoplasm|positive regulation of secretion|palmitoyl-CoA ligase activity|positive regulation of phosphatidylcholine biosynthetic process","WP368,WP4321,WP4724,WP5323,WP5061,WP4718,WP5241,WP4313,WP357,WP4352,WP5123,WP5329,WP143,WP3942,WP4723","Mitochondrial long chain fatty acid beta-oxidation|Thermogenesis|Omega-9 fatty acid synthesis|Fatty Acids and Lipoproteins Transport in Hepatocytes|Fatty acid transporters|Cholesterol metabolism with Bloch and Kandutsch-Russell pathways|Mitochondrial beta-oxidation|Ferroptosis|Fatty acid biosynthesis|Ciliary landscape|Mitochondrial fatty acid oxidation disorders|Cholesterol biosynthesis pathway in hepatocytes|Fatty acid beta-oxidation|PPAR signaling pathway|Omega-3 / omega-6 fatty acid synthesis","R-HSA-1430728,R-HSA-163685,R-HSA-400451,R-HSA-422356,R-HSA-434313,R-HSA-556833,R-HSA-75105,R-HSA-75876,R-HSA-8978868","Metabolism|Integration of energy metabolism|Free fatty acids regulate insulin secretion|Regulation of insulin secretion|Intracellular metabolism of fatty acids regulates insulin secretion|Metabolism of lipids|Fatty acyl-CoA biosynthesis|Synthesis of very long-chain fatty acyl-CoAs|Fatty acid metabolism"]
["ACSL4",53.0034011629423,47.8876259487736,37.5180628165451,33.2581912141149,63.5011988015614,46.1379538299565,40.299496339816,39.7109928603421,48.2048718560755,27.4631676072701,25.1581770164545,36.9039636172307,61.1167520096759,38.2753728797779,45.9577480198475,53.1109042744585,34.4404411256964,26.1247121609437,24.1195265167335,36.3105080459492,36.0496753075263,30.7502998933145,41.1724758002734,39.7838064022273,40.7485956584375,25.2620614574556,33.5330681178655,25.5955217369707,2182,"acyl-CoA synthetase long chain family member 4","protein_coding","hsa00061,hsa00071,hsa04146,hsa04216,hsa04920,hsa03320,hsa04714","Fatty acid biosynthesis|Fatty acid degradation|Peroxisome|Ferroptosis|Adipocytokine signaling pathway|PPAR signaling pathway|Thermogenesis","GO:0001676,GO:0004467,GO:0005524,GO:0005737,GO:0005741,GO:0005778,GO:0005783,GO:0005789,GO:0005811,GO:0005886,GO:0006629,GO:0006631,GO:0016020,GO:0030182,GO:0031957,GO:0032024,GO:0035336,GO:0035338,GO:0044233,GO:0047676,GO:0060136,GO:0070062,GO:0090433","long-chain fatty acid metabolic process|long-chain fatty acid-CoA ligase activity|ATP binding|cytoplasm|mitochondrial outer membrane|peroxisomal membrane|endoplasmic reticulum|endoplasmic reticulum membrane|lipid droplet|plasma membrane|lipid metabolic process|fatty acid metabolic process|membrane|neuron differentiation|very long-chain fatty acid-CoA ligase activity|positive regulation of insulin secretion|long-chain fatty-acyl-CoA metabolic process|long-chain fatty-acyl-CoA biosynthetic process|mitochondria-associated endoplasmic reticulum membrane|arachidonate-CoA ligase activity|embryonic process involved in female pregnancy|extracellular exosome|palmitoyl-CoA ligase activity","WP368,WP4321,WP4724,WP5061,WP4718,WP4313,WP357,WP5123,WP143,WP3942,WP4723","Mitochondrial long chain fatty acid beta-oxidation|Thermogenesis|Omega-9 fatty acid synthesis|Fatty acid transporters|Cholesterol metabolism with Bloch and Kandutsch-Russell pathways|Ferroptosis|Fatty acid biosynthesis|Mitochondrial fatty acid oxidation disorders|Fatty acid beta-oxidation|PPAR signaling pathway|Omega-3 / omega-6 fatty acid synthesis","R-HSA-1430728,R-HSA-163685,R-HSA-400451,R-HSA-422356,R-HSA-434313,R-HSA-556833,R-HSA-75105,R-HSA-75876,R-HSA-8978868","Metabolism|Integration of energy metabolism|Free fatty acids regulate insulin secretion|Regulation of insulin secretion|Intracellular metabolism of fatty acids regulates insulin secretion|Metabolism of lipids|Fatty acyl-CoA biosynthesis|Synthesis of very long-chain fatty acyl-CoAs|Fatty acid metabolism"]
["ACSL5",0.0071463985247198,0.0203922320202061,0.0268371788919935,0.0205614363356172,0.0418989588871445,0.0134216648022509,0.100012879303884,7.00773611347768E-3,0.0215649245177769,0.0344144887916822,0.0268830986384097,0.00718987068321165,0.0475731314228987,0.0545057286035977,0.0664611065156827,0.0813104562475511,0.0824499515119997,0.0066123108617246,0.00660485392800189,0.0274885135142245,0.0472159835982171,0.0271716607675349,0.0352753430404423,0.0698183569927746,0.0212553163154903,0.0203710919886899,0.00691543859887163,0.0201553244359462,51703,"acyl-CoA synthetase long chain family member 5","protein_coding","hsa00061,hsa00071,hsa04146,hsa04216,hsa04920,hsa03320,hsa04714","Fatty acid biosynthesis|Fatty acid degradation|Peroxisome|Ferroptosis|Adipocytokine signaling pathway|PPAR signaling pathway|Thermogenesis","GO:0001676,GO:0004467,GO:0005515,GO:0005524,GO:0005654,GO:0005730,GO:0005739,GO:0005741,GO:0005783,GO:0005789,GO:0005886,GO:0010747,GO:0016020,GO:0035338,GO:0047676","long-chain fatty acid metabolic process|long-chain fatty acid-CoA ligase activity|protein binding|ATP binding|nucleoplasm|nucleolus|mitochondrion|mitochondrial outer membrane|endoplasmic reticulum|endoplasmic reticulum membrane|plasma membrane|positive regulation of long-chain fatty acid import across plasma membrane|membrane|long-chain fatty-acyl-CoA biosynthetic process|arachidonate-CoA ligase activity","WP4321,WP5323,WP5061,WP4313,WP357,WP143,WP3942","Thermogenesis|Fatty Acids and Lipoproteins Transport in Hepatocytes|Fatty acid transporters|Ferroptosis|Fatty acid biosynthesis|Fatty acid beta-oxidation|PPAR signaling pathway","R-HSA-1430728,R-HSA-556833,R-HSA-75105,R-HSA-75876,R-HSA-8978868","Metabolism|Metabolism of lipids|Fatty acyl-CoA biosynthesis|Synthesis of very long-chain fatty acyl-CoAs|Fatty acid metabolism"]
["ACSL6",0.00395484378451336,0,0,0,0.0386450686918791,0.00371379985578717,0.00368983353613313,0,0,0,0,0,0,0,0,0,0,0.014637110663395,0,0,0,0.00375922478048495,0,0,0,0.0037578129392282,0,0,23305,"acyl-CoA synthetase long chain family member 6","protein_coding","hsa00061,hsa00071,hsa04146,hsa04216,hsa04920,hsa03320,hsa04714","Fatty acid biosynthesis|Fatty acid degradation|Peroxisome|Ferroptosis|Adipocytokine signaling pathway|PPAR signaling pathway|Thermogenesis","GO:0000038,GO:0001676,GO:0004467,GO:0005524,GO:0005741,GO:0005778,GO:0005783,GO:0005789,GO:0005886,GO:0006637,GO:0007405,GO:0016020,GO:0035338,GO:0042803,GO:0047676","very long-chain fatty acid metabolic process|long-chain fatty acid metabolic process|long-chain fatty acid-CoA ligase activity|ATP binding|mitochondrial outer membrane|peroxisomal membrane|endoplasmic reticulum|endoplasmic reticulum membrane|plasma membrane|acyl-CoA metabolic process|neuroblast proliferation|membrane|long-chain fatty-acyl-CoA biosynthetic process|protein homodimerization activity|arachidonate-CoA ligase activity","WP4321,WP5316,WP5323,WP5061,WP4313,WP357,WP143,WP3942","Thermogenesis|Primary ovarian insufficiency|Fatty Acids and Lipoproteins Transport in Hepatocytes|Fatty acid transporters|Ferroptosis|Fatty acid biosynthesis|Fatty acid beta-oxidation|PPAR signaling pathway","R-HSA-1430728,R-HSA-556833,R-HSA-75105,R-HSA-75876,R-HSA-8978868","Metabolism|Metabolism of lipids|Fatty acyl-CoA biosynthesis|Synthesis of very long-chain fatty acyl-CoAs|Fatty acid metabolism"]
["ACSM1",0,0,0,0,0,0,0,0,0,0.00490873328501514,0.00479311060994901,0,0,0,0,0,0,0,0,0.0049010527971098,0,0,0,0,5.05294341350158E-3,0,0,0.00479144663593553,116285,"acyl-CoA synthetase medium chain family member 1","protein_coding","hsa00650,hsa00785","Butanoate metabolism|Lipoic acid metabolism","GO:0001676,GO:0004321,GO:0004467,GO:0005515,GO:0005524,GO:0005525,GO:0005759,GO:0006633,GO:0006637,GO:0006805,GO:0015645,GO:0015980,GO:0016405,GO:0018858,GO:0018874,GO:0019395,GO:0019605,GO:0042632,GO:0046872,GO:0047760,GO:0070062,GO:0072562,GO:0102391","long-chain fatty acid metabolic process|fatty-acyl-CoA synthase activity|long-chain fatty acid-CoA ligase activity|protein binding|ATP binding|GTP binding|mitochondrial matrix|fatty acid biosynthetic process|acyl-CoA metabolic process|xenobiotic metabolic process|fatty acid ligase activity|energy derivation by oxidation of organic compounds|CoA-ligase activity|benzoate-CoA ligase activity|benzoate metabolic process|fatty acid oxidation|butyrate metabolic process|cholesterol homeostasis|metal ion binding|butyrate-CoA ligase activity|extracellular exosome|blood microparticle|decanoate-CoA ligase activity","WP3871","Valproic acid pathway","R-HSA-1430728,R-HSA-156580,R-HSA-156587,R-HSA-159424,R-HSA-177135,R-HSA-177162,R-HSA-211859","Metabolism|Phase II - Conjugation of compounds|Amino Acid conjugation|Conjugation of carboxylic acids|Conjugation of benzoate with glycine|Conjugation of phenylacetate with glutamine|Biological oxidations"]
["ACSM2B",0,0.00727371150640355,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,348158,"acyl-CoA synthetase medium chain family member 2B","protein_coding","hsa00650","Butanoate metabolism","GO:0004321,GO:0005515,GO:0005524,GO:0005739,GO:0005759,GO:0006633,GO:0006637,GO:0006805,GO:0015645,GO:0016405,GO:0018858,GO:0046872,GO:0047760,GO:0102391","fatty-acyl-CoA synthase activity|protein binding|ATP binding|mitochondrion|mitochondrial matrix|fatty acid biosynthetic process|acyl-CoA metabolic process|xenobiotic metabolic process|fatty acid ligase activity|CoA-ligase activity|benzoate-CoA ligase activity|metal ion binding|butyrate-CoA ligase activity|decanoate-CoA ligase activity",null,null,"R-HSA-1430728,R-HSA-156580,R-HSA-156587,R-HSA-159424,R-HSA-177128,R-HSA-177135,R-HSA-177162,R-HSA-211859,R-HSA-9748784,R-HSA-9749641","Metabolism|Phase II - Conjugation of compounds|Amino Acid conjugation|Conjugation of carboxylic acids|Conjugation of salicylate with glycine|Conjugation of benzoate with glycine|Conjugation of phenylacetate with glutamine|Biological oxidations|Drug ADME|Aspirin ADME"]
["ACSM3",0.0821001479245983,0.058568146583922,0.102771409929542,0.11810823024053,0.140393415032508,0.0578221670947737,0.140430943758943,0.147596440010363,0.0688180163122289,0.131788275860127,0.090078849803118,0.172082437925598,0.0390382563583409,0.0782724397053696,0.114529017461644,0.0454086566573676,0.105245758748989,0.0506429168942643,0.113818061496349,0.105265657843304,0.0452027132315926,0.0650326804664605,0.303940950643892,0.193839858749381,0.257753977952379,0.110514035759962,0.29130495263389,0.25084682462971,6296,"acyl-CoA synthetase medium chain family member 3","protein_coding","hsa00650","Butanoate metabolism","GO:0004321,GO:0005524,GO:0005739,GO:0005759,GO:0006633,GO:0006637,GO:0008217,GO:0015645,GO:0018729,GO:0042632,GO:0043759,GO:0046872,GO:0047760,GO:0050218","fatty-acyl-CoA synthase activity|ATP binding|mitochondrion|mitochondrial matrix|fatty acid biosynthetic process|acyl-CoA metabolic process|regulation of blood pressure|fatty acid ligase activity|propionate CoA-transferase activity|cholesterol homeostasis|methylbutanoate-CoA ligase activity|metal ion binding|butyrate-CoA ligase activity|propionate-CoA ligase activity",null,null,"R-HSA-1430728,R-HSA-556833,R-HSA-77286,R-HSA-77289,R-HSA-77352,R-HSA-8978868","Metabolism|Metabolism of lipids|mitochondrial fatty acid beta-oxidation of saturated fatty acids|Mitochondrial Fatty Acid Beta-Oxidation|Beta oxidation of butanoyl-CoA to acetyl-CoA|Fatty acid metabolism"]
["ACSM4",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.0108806244134299,0,0,0,0,0,0.0109079932327737,0,0,0,0,0,0,341392,"acyl-CoA synthetase medium chain family member 4","protein_coding","hsa00650","Butanoate metabolism","GO:0004321,GO:0005524,GO:0005759,GO:0006633,GO:0006637,GO:0015645,GO:0046872,GO:0047760,GO:0102391","fatty-acyl-CoA synthase activity|ATP binding|mitochondrial matrix|fatty acid biosynthetic process|acyl-CoA metabolic process|fatty acid ligase activity|metal ion binding|butyrate-CoA ligase activity|decanoate-CoA ligase activity",null,null,"R-HSA-1430728,R-HSA-156580,R-HSA-156587,R-HSA-159424,R-HSA-177128,R-HSA-211859,R-HSA-9748784,R-HSA-9749641","Metabolism|Phase II - Conjugation of compounds|Amino Acid conjugation|Conjugation of carboxylic acids|Conjugation of salicylate with glycine|Biological oxidations|Drug ADME|Aspirin ADME"]
["ACSS1",0.684236677245427,0.992343375534348,1.41833714803177,0.981085567274038,0.96650161039864,0.897001667304196,1.23884932267593,1.08283700454037,0.763207193723558,1.19404351169476,1.66923841372137,1.11779631153561,0.78599769901681,1.60823405582118,1.42388118606778,1.02773910016172,0.61877179410258,0.783539726389331,0.713782364381059,0.534198742397821,0.601058301527758,0.650392180568567,0.789188946264323,0.595675693186909,0.617919484716991,0.566465509789543,0.708012996897192,0.815222679305169,84532,"acyl-CoA synthetase short chain family member 1","protein_coding","hsa00010,hsa00620,hsa00630,hsa00640","Glycolysis / Gluconeogenesis|Pyruvate metabolism|Glyoxylate and dicarboxylate metabolism|Propanoate metabolism","GO:0003987,GO:0005515,GO:0005524,GO:0005739,GO:0005759,GO:0006069,GO:0006085,GO:0016208,GO:0019413,GO:0019427,GO:0019542,GO:0050218","acetate-CoA ligase activity|protein binding|ATP binding|mitochondrion|mitochondrial matrix|ethanol oxidation|acetyl-CoA biosynthetic process|AMP binding|acetate biosynthetic process|acetyl-CoA biosynthetic process from acetate|propionate biosynthetic process|propionate-CoA ligase activity","WP1982,WP430,WP5111,WP3925","Sterol regulatory element-binding proteins (SREBP) signaling|Statin inhibition of cholesterol production|Familial hyperlipidemia type 4|Amino acid metabolism","R-HSA-1430728,R-HSA-211859,R-HSA-211945,R-HSA-71384","Metabolism|Biological oxidations|Phase I - Functionalization of compounds|Ethanol oxidation"]
["ACSS2",14.40389347502,16.6278125290569,21.2435452205883,19.1014725664996,15.810807212731,20.5905198202389,22.0762009806739,18.5572050825698,12.4162010123721,15.1178930780463,14.1970542230807,12.955933410632,12.1275065103805,16.2370912799287,15.0399263191183,15.1595949239729,10.0956717288832,11.8920364959855,11.9634176960051,12.1588023074793,10.643097111877,12.2168477957714,11.1815328330525,11.2936204149557,10.2120658653472,12.7273775705475,11.0328719114753,12.0201814999043,55902,"acyl-CoA synthetase short chain family member 2","protein_coding","hsa00010,hsa00620,hsa00630,hsa00640","Glycolysis / Gluconeogenesis|Pyruvate metabolism|Glyoxylate and dicarboxylate metabolism|Propanoate metabolism","GO:0003987,GO:0005524,GO:0005737,GO:0005759,GO:0005829,GO:0006069,GO:0006085,GO:0008610,GO:0016208,GO:0019413,GO:0019427,GO:0019542,GO:0050218","acetate-CoA ligase activity|ATP binding|cytoplasm|mitochondrial matrix|cytosol|ethanol oxidation|acetyl-CoA biosynthetic process|lipid biosynthetic process|AMP binding|acetate biosynthetic process|acetyl-CoA biosynthetic process from acetate|propionate biosynthetic process|propionate-CoA ligase activity","WP3996,WP4966,WP3965,WP521,WP357,WP143","Ethanol effects on histone modifications|Fluoroacetic acid toxicity|Lipid metabolism pathway|Amino acid conjugation of benzoic acid|Fatty acid biosynthesis|Fatty acid beta-oxidation","R-HSA-1430728,R-HSA-1592230,R-HSA-1852241,R-HSA-211859,R-HSA-211945,R-HSA-2151201,R-HSA-71384","Metabolism|Mitochondrial biogenesis|Organelle biogenesis and maintenance|Biological oxidations|Phase I - Functionalization of compounds|Transcriptional activation of mitochondrial biogenesis|Ethanol oxidation"]
["ACSS3",3.35057923671426,3.45729239130078,2.97368581000882,2.64704244329298,3.60422671769089,3.24125972118446,2.8579437934413,3.2298274820407,3.22093470067906,2.30546111540409,2.2838256783411,2.96746245674173,3.39659355843208,3.33888134952968,2.91043898937629,3.11397964117066,3.145474665329,2.58006854401188,2.55380979256914,2.3474050553591,2.6378588292817,2.58149876397088,2.55642097089525,3.10373678107083,2.85534397319318,2.44550154521207,2.69223468860654,2.47006932593829,79611,"acyl-CoA synthetase short chain family member 3","protein_coding","hsa00640","Propanoate metabolism","GO:0003987,GO:0005515,GO:0005524,GO:0005739,GO:0005759,GO:0043231,GO:0046951,GO:0047760,GO:0050218","acetate-CoA ligase activity|protein binding|ATP binding|mitochondrion|mitochondrial matrix|intracellular membrane-bounded organelle|ketone body biosynthetic process|butyrate-CoA ligase activity|propionate-CoA ligase activity",null,null,"R-HSA-1430728,R-HSA-556833,R-HSA-74182,R-HSA-77111","Metabolism|Metabolism of lipids|Ketone body metabolism|Synthesis of Ketone Bodies"]
["ACTA1",0,0.0171964004427045,0,0,0.0353326342325752,0.0509321123079383,0,0.0354569827230554,0.0181853108162429,0.0522380087413382,0,0.0363785274541574,0.0171932405602351,0.0172363856717614,0.016813634726838,0,0,0.0167281264724515,0,0.0173854247108744,0.0682566600105299,0.0515550827037936,0,0,0.01792422381892,0,0,0,58,"actin alpha 1%2C skeletal muscle","protein_coding","hsa04814","Motor proteins","GO:0001725,GO:0005200,GO:0005515,GO:0005524,GO:0005615,GO:0005829,GO:0005865,GO:0005884,GO:0006936,GO:0009612,GO:0009991,GO:0010628,GO:0015629,GO:0016787,GO:0017022,GO:0030017,GO:0030027,GO:0030175,GO:0030240,GO:0043503,GO:0043531,GO:0044297,GO:0048545,GO:0048741,GO:0070062,GO:0071417,GO:0072562,GO:0090131","stress fiber|structural constituent of cytoskeleton|protein binding|ATP binding|extracellular space|cytosol|striated muscle thin filament|actin filament|muscle contraction|response to mechanical stimulus|response to extracellular stimulus|positive regulation of gene expression|actin cytoskeleton|hydrolase activity|myosin binding|sarcomere|lamellipodium|filopodium|skeletal muscle thin filament assembly|skeletal muscle fiber adaptation|ADP binding|cell body|response to steroid hormone|skeletal muscle fiber development|extracellular exosome|cellular response to organonitrogen compound|blood microparticle|mesenchyme migration","WP289,WP383,WP5055,WP4754,WP314,WP3680,WP4534,WP5087","Myometrial relaxation and contraction pathways|Striated muscle contraction pathway|Burn wound healing|IL-18 signaling pathway|Fas ligand pathway and stress induction of heat shock proteins|Physico-chemical features and toxicity-associated pathways|Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms|Pleural mesothelioma","R-HSA-390522,R-HSA-397014","Striated Muscle Contraction|Muscle contraction"]
["ACTA2",59.8612854919807,57.0798274705707,42.916300567107,62.1148254526046,65.9386101443926,63.0171363033856,42.4821963702951,58.5535887075506,50.2244388451791,66.4996496599143,53.3235331564853,56.4604001687322,42.2809363029735,42.1880368786603,31.62759076912,37.871379367039,70.6833979321622,57.4568121215824,29.9292818493755,54.4240335475092,74.6534095411489,60.9960501939671,25.4930845927971,50.7628111935818,72.3851834875587,65.3647949741695,26.6765644890769,57.9585231192531,59,"actin alpha 2%2C smooth muscle","protein_coding","hsa04371,hsa04814,hsa04926,hsa04270","Apelin signaling pathway|Motor proteins|Relaxin signaling pathway|Vascular smooth muscle contraction","GO:0001725,GO:0005524,GO:0005604,GO:0005615,GO:0005737,GO:0005829,GO:0008217,GO:0009615,GO:0010628,GO:0014829,GO:0016787,GO:0019901,GO:0030027,GO:0030175,GO:0030485,GO:0031514,GO:0032991,GO:0044297,GO:0061870,GO:0061874,GO:0070062,GO:0070374,GO:0071560,GO:0072051,GO:0072144,GO:0090131,GO:2000491","stress fiber|ATP binding|basement membrane|extracellular space|cytoplasm|cytosol|regulation of blood pressure|response to virus|positive regulation of gene expression|vascular associated smooth muscle contraction|hydrolase activity|protein kinase binding|lamellipodium|filopodium|smooth muscle contractile fiber|motile cilium|protein-containing complex|cell body|positive regulation of hepatic stellate cell migration|positive regulation of hepatic stellate cell contraction|extracellular exosome|positive regulation of ERK1 and ERK2 cascade|cellular response to transforming growth factor beta stimulus|juxtaglomerular apparatus development|glomerular mesangial cell development|mesenchyme migration|positive regulation of hepatic stellate cell activation","WP289,WP5413,WP5097,WP383,WP5036,WP5353,WP4754,WP4657,WP5158,WP5236,WP5347,WP4534,WP4838,WP5087","Myometrial relaxation and contraction pathways|IL-24 Signaling pathway|CCL18 signaling pathway|Striated muscle contraction pathway|Angiotensin II receptor type 1 pathway|A network map of Macrophage-stimulating protein (MSP) signaling|IL-18 signaling pathway|22q11.2 copy number variation syndrome|Urotensin-II-mediated signaling pathway|Markers of kidney cell lineage|IL-26 signaling pathways|Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms|Regucalcin in proximal tubule epithelial kidney cells|Pleural mesothelioma","R-HSA-157118,R-HSA-162582,R-HSA-397014,R-HSA-445355,R-HSA-9013694,R-HSA-9013695","Signaling by NOTCH|Signal Transduction|Muscle contraction|Smooth Muscle Contraction|Signaling by NOTCH4|NOTCH4 Intracellular Domain Regulates Transcription"]
["ACTA2-AS1",2.74444090500762,0.363952598503232,0.619370036592018,1.3540019498777,1.41823429772018,0.619511987690782,0.726306616522136,2.21246886247012,2.03058622581193,1.28350040371461,0.223354731418681,1.73898442507916,0.5395546901803,0.553487932261497,0.343580823581025,0.537943822871912,1.10365091727785,0.146500067961381,0.280475138217196,1.06579546377325,0.523050484970558,0.677256637104461,0.560109597629719,1.44374656723424,1.94910799774227,1.02804050195296,0.638400254403911,0.694640151942208,100132116,"ACTA2 antisense RNA 1","non_coding"]
["ACTB",3783.24232697278,4625.48531411371,4791.96469995878,5165.49372258912,3823.51238506165,4789.96165897821,4756.55219343738,4628.63665102333,4231.73094970326,5689.23761128559,5482.15824791145,4877.51867586163,3954.35899259808,4552.12163675711,4200.97457403707,4122.43642222303,4698.45832487066,5599.94799806422,5067.67171814196,5024.88391685854,5158.40305787671,5685.54934764079,4207.2510578612,4473.54418019439,4586.15757900312,5904.13752205285,4260.00858069567,5801.19729785425,60,"actin beta","protein_coding","hsa03082,hsa04015,hsa04390,hsa04145,hsa04210,hsa04510,hsa04520,hsa04530,hsa04814,hsa04810,hsa04611,hsa04613,hsa04670,hsa04921,hsa04919,hsa04971,hsa04714,hsa05205,hsa05225,hsa05164,hsa05110,hsa05130,hsa05132,hsa05131,hsa05135,hsa05100,hsa05014,hsa05418,hsa05410,hsa05412,hsa05414,hsa05416","ATP-dependent chromatin remodeling|Rap1 signaling pathway|Hippo signaling pathway|Phagosome|Apoptosis|Focal adhesion|Adherens junction|Tight junction|Motor proteins|Regulation of actin cytoskeleton|Platelet activation|Neutrophil extracellular trap formation|Leukocyte transendothelial migration|Oxytocin signaling pathway|Thyroid hormone signaling pathway|Gastric acid secretion|Thermogenesis|Proteoglycans in cancer|Hepatocellular carcinoma|Influenza A|Vibrio cholerae infection|Pathogenic Escherichia coli infection|Salmonella infection|Shigellosis|Yersinia infection|Bacterial invasion of epithelial cells|Amyotrophic lateral sclerosis|Fluid shear stress and atherosclerosis|Hypertrophic cardiomyopathy|Arrhythmogenic right ventricular cardiomyopathy|Dilated cardiomyopathy|Viral myocarditis","GO:0000079,GO:0000776,GO:0000785,GO:0000786,GO:0001738,GO:0001895,GO:0005200,GO:0005515,GO:0005524,GO:0005615,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005856,GO:0005884,GO:0005886,GO:0005903,GO:0005911,GO:0005912,GO:0005925,GO:0006338,GO:0006357,GO:0007163,GO:0007409,GO:0008284,GO:0015629,GO:0016020,GO:0016363,GO:0016514,GO:0016586,GO:0016787,GO:0019894,GO:0019901,GO:0021762,GO:0022898,GO:0030027,GO:0030071,GO:0030424,GO:0030863,GO:0030957,GO:0031492,GO:0031982,GO:0032091,GO:0032991,GO:0034333,GO:0035060,GO:0035267,GO:0035633,GO:0036464,GO:0042802,GO:0042981,GO:0043296,GO:0044305,GO:0045176,GO:0045202,GO:0045582,GO:0045596,GO:0045597,GO:0045663,GO:0045893,GO:0048156,GO:0048870,GO:0050998,GO:0051621,GO:0051623,GO:0051726,GO:0070062,GO:0070160,GO:0070316,GO:0070527,GO:0071564,GO:0071565,GO:0071896,GO:0072562,GO:0072749,GO:0097433,GO:0098685,GO:0098793,GO:0098871,GO:0098973,GO:0098974,GO:0098978,GO:0140092,GO:0140288,GO:0150111,GO:1900242,GO:1902459,GO:1903076,GO:1905168,GO:1990904,GO:2000045,GO:2000779,GO:2000781,GO:2000819","regulation of cyclin-dependent protein serine/threonine kinase activity|kinetochore|chromatin|nucleosome|morphogenesis of a polarized epithelium|retina homeostasis|structural constituent of cytoskeleton|protein binding|ATP binding|extracellular space|nucleus|nucleoplasm|cytoplasm|cytosol|cytoskeleton|actin filament|plasma membrane|brush border|cell-cell junction|adherens junction|focal adhesion|chromatin remodeling|regulation of transcription by RNA polymerase II|establishment or maintenance of cell polarity|axonogenesis|positive regulation of cell population proliferation|actin cytoskeleton|membrane|nuclear matrix|SWI/SNF complex|RSC-type complex|hydrolase activity|kinesin binding|protein kinase binding|substantia nigra development|regulation of transmembrane transporter activity|lamellipodium|regulation of mitotic metaphase/anaphase transition|axon|cortical cytoskeleton|Tat protein binding|nucleosomal DNA binding|vesicle|negative regulation of protein binding|protein-containing complex|adherens junction assembly|brahma complex|NuA4 histone acetyltransferase complex|maintenance of blood-brain barrier|cytoplasmic ribonucleoprotein granule|identical protein binding|regulation of apoptotic process|apical junction complex|calyx of Held|apical protein localization|synapse|positive regulation of T cell differentiation|negative regulation of cell differentiation|positive regulation of cell differentiation|positive regulation of myoblast differentiation|positive regulation of DNA-templated transcription|tau protein binding|cell motility|nitric-oxide synthase binding|regulation of norepinephrine uptake|positive regulation of norepinephrine uptake|regulation of cell cycle|extracellular exosome|tight junction|regulation of G0 to G1 transition|platelet aggregation|npBAF complex|nBAF complex|protein localization to adherens junction|blood microparticle|cellular response to cytochalasin B|dense body|Schaffer collateral - CA1 synapse|presynapse|postsynaptic actin cytoskeleton|structural constituent of postsynaptic actin cytoskeleton|postsynaptic actin cytoskeleton organization|glutamatergic synapse|bBAF complex|GBAF complex|regulation of transepithelial transport|regulation of synaptic vesicle endocytosis|positive regulation of stem cell population maintenance|regulation of protein localization to plasma membrane|positive regulation of double-strand break repair via homologous recombination|ribonucleoprotein complex|regulation of G1/S transition of mitotic cell cycle|regulation of double-strand break repair|positive regulation of double-strand break repair|regulation of nucleotide-excision repair","WP306,WP5115,WP4321,WP289,WP5413,WP2636,WP2118,WP51,WP4298,WP314,WP4879,WP2272,WP4534,WP5087,WP4217","Focal adhesion|Network map of SARS-CoV-2 signaling pathway|Thermogenesis|Myometrial relaxation and contraction pathways|IL-24 Signaling pathway|Common pathways underlying drug addiction|Arrhythmogenic right ventricular cardiomyopathy|Regulation of actin cytoskeleton|Acute viral myocarditis|Fas ligand pathway and stress induction of heat shock proteins|Overlap between signal transduction pathways contributing to LMNA laminopathies|Pathogenic Escherichia coli infection|Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms|Pleural mesothelioma|Ebola virus infection in host","R-HSA-109582,R-HSA-1266738,R-HSA-1266738,R-HSA-1445148,R-HSA-1500931,R-HSA-1500931,R-HSA-157858,R-HSA-162582,R-HSA-162582,R-HSA-1643685,R-HSA-1643685,R-HSA-168249,R-HSA-168249,R-HSA-168256,R-HSA-168256,R-HSA-190828,R-HSA-190873,R-HSA-194138,R-HSA-194315,R-HSA-194315,R-HSA-195258,R-HSA-195258,R-HSA-196025,R-HSA-199991,R-HSA-199991,R-HSA-2029480,R-HSA-2029480,R-HSA-2029482,R-HSA-2029482,R-HSA-212165,R-HSA-2682334,R-HSA-3214847,R-HSA-3247509,R-HSA-373760,R-HSA-373760,R-HSA-389957,R-HSA-389958,R-HSA-390450,R-HSA-390466,R-HSA-391251,R-HSA-392499,R-HSA-392499,R-HSA-3928662,R-HSA-3928665,R-HSA-418990,R-HSA-418990,R-HSA-421270,R-HSA-421270,R-HSA-422475,R-HSA-422475,R-HSA-437239,R-HSA-437239,R-HSA-4420097,R-HSA-445095,R-HSA-445095,R-HSA-446353,R-HSA-446728,R-HSA-446728,R-HSA-4839726,R-HSA-5250913,R-HSA-5250924,R-HSA-5626467,R-HSA-5653656,R-HSA-5653656,R-HSA-5663202,R-HSA-5663205,R-HSA-5663205,R-HSA-5663213,R-HSA-5663213,R-HSA-5663220,R-HSA-5663220,R-HSA-5673001,R-HSA-5674135,R-HSA-5683057,R-HSA-5684996,R-HSA-5688426,R-HSA-5689603,R-HSA-5696394,R-HSA-5696398,R-HSA-5696399,R-HSA-597592,R-HSA-6802946,R-HSA-6802948,R-HSA-6802949,R-HSA-6802952,R-HSA-6802955,R-HSA-6802957,R-HSA-73894,R-HSA-74160,R-HSA-8856828,R-HSA-9006934,R-HSA-9012999,R-HSA-9035034,R-HSA-9649948,R-HSA-9656223,R-HSA-9658195,R-HSA-9658195,R-HSA-9659379,R-HSA-9662360,R-HSA-9662361,R-HSA-9664407,R-HSA-9664407,R-HSA-9664417,R-HSA-9664417,R-HSA-9664422,R-HSA-9664422,R-HSA-9675108,R-HSA-9675108,R-HSA-9709957,R-HSA-9716542,R-HSA-9716542,R-HSA-9824443,R-HSA-9824443,R-HSA-983231","Hemostasis|Developmental Biology|Developmental Biology|Translocation of SLC2A4 (GLUT4) to the plasma membrane|Cell-Cell communication|Cell-Cell communication|Gap junction trafficking and regulation|Signal Transduction|Signal Transduction|Disease|Disease|Innate Immune System|Innate Immune System|Immune System|Immune System|Gap junction trafficking|Gap junction degradation|Signaling by VEGF|Signaling by Rho GTPases|Signaling by Rho GTPases|RHO GTPase Effectors|RHO GTPase Effectors|Formation of annular gap junctions|Membrane Trafficking|Membrane Trafficking|Fcgamma receptor (FCGR) dependent phagocytosis|Fcgamma receptor (FCGR) dependent phagocytosis|Regulation of actin dynamics for phagocytic cup formation|Regulation of actin dynamics for phagocytic cup formation|Epigenetic regulation of gene expression|EPH-Ephrin signaling|HATs acetylate histones|Chromatin modifying enzymes|L1CAM interactions|L1CAM interactions|Prefoldin mediated transfer of substrate  to CCT/TriC|Cooperation of Prefoldin and TriC/CCT  in actin and tubulin folding|Folding of actin by CCT/TriC|Chaperonin-mediated protein folding|Protein folding|Metabolism of proteins|Metabolism of proteins|EPHB-mediated forward signaling|EPH-ephrin mediated repulsion of cells|Adherens junctions interactions|Adherens junctions interactions|Cell-cell junction organization|Cell-cell junction organization|Axon guidance|Axon guidance|Recycling pathway of L1|Recycling pathway of L1|VEGFA-VEGFR2 Pathway|Interaction between L1 and Ankyrins|Interaction between L1 and Ankyrins|Cell-extracellular matrix interactions|Cell junction organization|Cell junction organization|Chromatin organization|Positive epigenetic regulation of rRNA expression|B-WICH complex positively regulates rRNA expression|RHO GTPases activate IQGAPs|Vesicle-mediated transport|Vesicle-mediated transport|Diseases of signal transduction by growth factor receptors and second messengers|Infectious disease|Infectious disease|RHO GTPases Activate WASPs and WAVEs|RHO GTPases Activate WASPs and WAVEs|RHO GTPases Activate Formins|RHO GTPases Activate Formins|RAF/MAP kinase cascade|MAP2K and MAPK activation|MAPK family signaling cascades|MAPK1/MAPK3 signaling|Deubiquitination|UCH proteinases|DNA Damage Recognition in GG-NER|Nucleotide Excision Repair|Global Genome Nucleotide Excision Repair (GG-NER)|Post-translational protein modification|Signaling by moderate kinase activity BRAF mutants|Signaling by high-kinase activity BRAF mutants|Signaling by RAS mutants|Signaling by BRAF and RAF1 fusions|Paradoxical activation of RAF signaling by kinase inactive BRAF|Oncogenic MAPK signaling|DNA Repair|Gene expression (Transcription)|Clathrin-mediated endocytosis|Signaling by Receptor Tyrosine Kinases|RHO GTPase cycle|RHOF GTPase cycle|Signaling downstream of RAS mutants|Signaling by RAF1 mutants|Leishmania infection|Leishmania infection|Sensory processing of sound|Sensory processing of sound by inner hair cells of the cochlea|Sensory processing of sound by outer hair cells of the cochlea|Parasite infection|Parasite infection|Leishmania phagocytosis|Leishmania phagocytosis|FCGR3A-mediated phagocytosis|FCGR3A-mediated phagocytosis|Nervous system development|Nervous system development|Sensory Perception|Signaling by Rho GTPases, Miro GTPases and RHOBTB3|Signaling by Rho GTPases, Miro GTPases and RHOBTB3|Parasitic Infection Pathways|Parasitic Infection Pathways|Factors involved in megakaryocyte development and platelet production"]
["ACTBL2",0,0,0,0,0,0,0.00900139777461827,0,0,0,0.00907328633357922,0.0582394965291503,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,345651,"actin beta like 2","protein_coding",null,null,"GO:0003674,GO:0005515,GO:0005524,GO:0005615,GO:0005737,GO:0005884,GO:0007409,GO:0008150,GO:0016020,GO:0019901,GO:0030424,GO:0035267,GO:0048870,GO:0070062,GO:0098973,GO:0098974,GO:0098978","molecular_function|protein binding|ATP binding|extracellular space|cytoplasm|actin filament|axonogenesis|biological_process|membrane|protein kinase binding|axon|NuA4 histone acetyltransferase complex|cell motility|extracellular exosome|structural constituent of postsynaptic actin cytoskeleton|postsynaptic actin cytoskeleton organization|glutamatergic synapse"]
["ACTC1",0.0195052208648647,0.0185527012012102,0.0366243989799564,0.0187066420303782,0.0190596807672828,0.0183163963943888,0,0,0,0,0.0366870651461944,0,0,0,0,0,0.0187530883443839,0,0,0,0,0,0,0,0,0,0,0,70,"actin alpha cardiac muscle 1","protein_coding","hsa04814,hsa04260,hsa04261,hsa05410,hsa05414","Motor proteins|Cardiac muscle contraction|Adrenergic signaling in cardiomyocytes|Hypertrophic cardiomyopathy|Dilated cardiomyopathy","GO:0000146,GO:0005524,GO:0005615,GO:0005737,GO:0005829,GO:0005884,GO:0005925,GO:0007015,GO:0010628,GO:0016020,GO:0016787,GO:0017022,GO:0030017,GO:0030027,GO:0030048,GO:0030175,GO:0030240,GO:0031032,GO:0031674,GO:0033275,GO:0043066,GO:0044297,GO:0055003,GO:0055008,GO:0060047,GO:0070062,GO:0072562,GO:0090131,GO:0098978","microfilament motor activity|ATP binding|extracellular space|cytoplasm|cytosol|actin filament|focal adhesion|actin filament organization|positive regulation of gene expression|membrane|hydrolase activity|myosin binding|sarcomere|lamellipodium|actin filament-based movement|filopodium|skeletal muscle thin filament assembly|actomyosin structure organization|I band|actin-myosin filament sliding|negative regulation of apoptotic process|cell body|cardiac myofibril assembly|cardiac muscle tissue morphogenesis|heart contraction|extracellular exosome|blood microparticle|mesenchyme migration|glutamatergic synapse","WP289,WP2406,WP383,WP4657,WP4534,WP5087","Myometrial relaxation and contraction pathways|Cardiac progenitor differentiation|Striated muscle contraction pathway|22q11.2 copy number variation syndrome|Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms|Pleural mesothelioma","R-HSA-162582,R-HSA-194315,R-HSA-390522,R-HSA-397014,R-HSA-8980692,R-HSA-9012999,R-HSA-9013026,R-HSA-9716542","Signal Transduction|Signaling by Rho GTPases|Striated Muscle Contraction|Muscle contraction|RHOA GTPase cycle|RHO GTPase cycle|RHOB GTPase cycle|Signaling by Rho GTPases, Miro GTPases and RHOBTB3"]
["ACTE1P",0,0,0,0.0119577147483731,0,0,0,0,0,0,0,0,0,0.0118868876209973,0,0,0,0,0,0,0,0,0,0,0,0,0,0,399923,"actin epsilon 1%2C pseudogene","non_coding"]
["ACTG1",2938.41263581975,3606.2966176824,4057.31478706334,3848.50780868429,3037.03911345143,3749.56697747266,4052.40499467634,3800.16530392872,3244.41605923016,4090.72955164221,3979.21134280611,3542.24575371482,3083.49759193521,3520.55997922087,3411.44353623128,3262.82072187375,3282.6804130112,3661.42735322211,3666.13653951634,3508.67204944127,3470.1779475714,3736.89154701851,3147.20789309784,3172.7280531725,3166.62610529775,3866.25644343933,3222.11611561214,3927.63095327884,71,"actin gamma 1","protein_coding","hsa03082,hsa04015,hsa04390,hsa04145,hsa04210,hsa04510,hsa04520,hsa04530,hsa04814,hsa04810,hsa04611,hsa04613,hsa04670,hsa04921,hsa04919,hsa04971,hsa04714,hsa05205,hsa05225,hsa05164,hsa05110,hsa05130,hsa05132,hsa05131,hsa05135,hsa05100,hsa05014,hsa05418,hsa05410,hsa05412,hsa05414,hsa05416","ATP-dependent chromatin remodeling|Rap1 signaling pathway|Hippo signaling pathway|Phagosome|Apoptosis|Focal adhesion|Adherens junction|Tight junction|Motor proteins|Regulation of actin cytoskeleton|Platelet activation|Neutrophil extracellular trap formation|Leukocyte transendothelial migration|Oxytocin signaling pathway|Thyroid hormone signaling pathway|Gastric acid secretion|Thermogenesis|Proteoglycans in cancer|Hepatocellular carcinoma|Influenza A|Vibrio cholerae infection|Pathogenic Escherichia coli infection|Salmonella infection|Shigellosis|Yersinia infection|Bacterial invasion of epithelial cells|Amyotrophic lateral sclerosis|Fluid shear stress and atherosclerosis|Hypertrophic cardiomyopathy|Arrhythmogenic right ventricular cardiomyopathy|Dilated cardiomyopathy|Viral myocarditis","GO:0001525,GO:0001738,GO:0001895,GO:0005200,GO:0005515,GO:0005522,GO:0005524,GO:0005615,GO:0005634,GO:0005737,GO:0005829,GO:0005856,GO:0005884,GO:0005886,GO:0005911,GO:0005925,GO:0007409,GO:0010628,GO:0016020,GO:0016787,GO:0019901,GO:0030016,GO:0030335,GO:0030424,GO:0031625,GO:0031941,GO:0035267,GO:0035633,GO:0042802,GO:0043296,GO:0044305,GO:0045202,GO:0045214,GO:0045335,GO:0048870,GO:0051492,GO:0051893,GO:0070062,GO:0070527,GO:0071346,GO:0072562,GO:0090303,GO:0097433,GO:0098685,GO:0098973,GO:0098974,GO:0120192,GO:0120220,GO:0150111,GO:1900242,GO:1902396","angiogenesis|morphogenesis of a polarized epithelium|retina homeostasis|structural constituent of cytoskeleton|protein binding|profilin binding|ATP binding|extracellular space|nucleus|cytoplasm|cytosol|cytoskeleton|actin filament|plasma membrane|cell-cell junction|focal adhesion|axonogenesis|positive regulation of gene expression|membrane|hydrolase activity|protein kinase binding|myofibril|positive regulation of cell migration|axon|ubiquitin protein ligase binding|filamentous actin|NuA4 histone acetyltransferase complex|maintenance of blood-brain barrier|identical protein binding|apical junction complex|calyx of Held|synapse|sarcomere organization|phagocytic vesicle|cell motility|regulation of stress fiber assembly|regulation of focal adhesion assembly|extracellular exosome|platelet aggregation|cellular response to type II interferon|blood microparticle|positive regulation of wound healing|dense body|Schaffer collateral - CA1 synapse|structural constituent of postsynaptic actin cytoskeleton|postsynaptic actin cytoskeleton organization|tight junction assembly|basal body patch|regulation of transepithelial transport|regulation of synaptic vesicle endocytosis|protein localization to bicellular tight junction","WP306,WP5115,WP4321,WP289,WP2636,WP383,WP2118,WP51,WP314,WP2272,WP4534,WP5087,WP3888,WP4217","Focal adhesion|Network map of SARS-CoV-2 signaling pathway|Thermogenesis|Myometrial relaxation and contraction pathways|Common pathways underlying drug addiction|Striated muscle contraction pathway|Arrhythmogenic right ventricular cardiomyopathy|Regulation of actin cytoskeleton|Fas ligand pathway and stress induction of heat shock proteins|Pathogenic Escherichia coli infection|Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms|Pleural mesothelioma|VEGFA-VEGFR2 signaling|Ebola virus infection in host","R-HSA-1266738,R-HSA-1266738,R-HSA-1445148,R-HSA-1500931,R-HSA-1500931,R-HSA-157858,R-HSA-162582,R-HSA-162582,R-HSA-1643685,R-HSA-1643685,R-HSA-168249,R-HSA-168249,R-HSA-168256,R-HSA-168256,R-HSA-190828,R-HSA-190873,R-HSA-194138,R-HSA-194315,R-HSA-194315,R-HSA-195258,R-HSA-195258,R-HSA-196025,R-HSA-199991,R-HSA-199991,R-HSA-2029480,R-HSA-2029480,R-HSA-2029482,R-HSA-2029482,R-HSA-2682334,R-HSA-373760,R-HSA-373760,R-HSA-3928662,R-HSA-3928665,R-HSA-418990,R-HSA-418990,R-HSA-421270,R-HSA-421270,R-HSA-422475,R-HSA-422475,R-HSA-437239,R-HSA-437239,R-HSA-4420097,R-HSA-445095,R-HSA-445095,R-HSA-446353,R-HSA-446728,R-HSA-446728,R-HSA-5626467,R-HSA-5653656,R-HSA-5653656,R-HSA-5663202,R-HSA-5663205,R-HSA-5663205,R-HSA-5663213,R-HSA-5663213,R-HSA-5663220,R-HSA-5663220,R-HSA-5673001,R-HSA-5674135,R-HSA-5683057,R-HSA-5684996,R-HSA-6802946,R-HSA-6802948,R-HSA-6802949,R-HSA-6802952,R-HSA-6802955,R-HSA-6802957,R-HSA-8856828,R-HSA-9006934,R-HSA-9012999,R-HSA-9013418,R-HSA-9649948,R-HSA-9656223,R-HSA-9658195,R-HSA-9658195,R-HSA-9659379,R-HSA-9662360,R-HSA-9662361,R-HSA-9664407,R-HSA-9664407,R-HSA-9664417,R-HSA-9664417,R-HSA-9664422,R-HSA-9664422,R-HSA-9675108,R-HSA-9675108,R-HSA-9706574,R-HSA-9709957,R-HSA-9716542,R-HSA-9716542,R-HSA-9824443,R-HSA-9824443","Developmental Biology|Developmental Biology|Translocation of SLC2A4 (GLUT4) to the plasma membrane|Cell-Cell communication|Cell-Cell communication|Gap junction trafficking and regulation|Signal Transduction|Signal Transduction|Disease|Disease|Innate Immune System|Innate Immune System|Immune System|Immune System|Gap junction trafficking|Gap junction degradation|Signaling by VEGF|Signaling by Rho GTPases|Signaling by Rho GTPases|RHO GTPase Effectors|RHO GTPase Effectors|Formation of annular gap junctions|Membrane Trafficking|Membrane Trafficking|Fcgamma receptor (FCGR) dependent phagocytosis|Fcgamma receptor (FCGR) dependent phagocytosis|Regulation of actin dynamics for phagocytic cup formation|Regulation of actin dynamics for phagocytic cup formation|EPH-Ephrin signaling|L1CAM interactions|L1CAM interactions|EPHB-mediated forward signaling|EPH-ephrin mediated repulsion of cells|Adherens junctions interactions|Adherens junctions interactions|Cell-cell junction organization|Cell-cell junction organization|Axon guidance|Axon guidance|Recycling pathway of L1|Recycling pathway of L1|VEGFA-VEGFR2 Pathway|Interaction between L1 and Ankyrins|Interaction between L1 and Ankyrins|Cell-extracellular matrix interactions|Cell junction organization|Cell junction organization|RHO GTPases activate IQGAPs|Vesicle-mediated transport|Vesicle-mediated transport|Diseases of signal transduction by growth factor receptors and second messengers|Infectious disease|Infectious disease|RHO GTPases Activate WASPs and WAVEs|RHO GTPases Activate WASPs and WAVEs|RHO GTPases Activate Formins|RHO GTPases Activate Formins|RAF/MAP kinase cascade|MAP2K and MAPK activation|MAPK family signaling cascades|MAPK1/MAPK3 signaling|Signaling by moderate kinase activity BRAF mutants|Signaling by high-kinase activity BRAF mutants|Signaling by RAS mutants|Signaling by BRAF and RAF1 fusions|Paradoxical activation of RAF signaling by kinase inactive BRAF|Oncogenic MAPK signaling|Clathrin-mediated endocytosis|Signaling by Receptor Tyrosine Kinases|RHO GTPase cycle|RHOBTB2 GTPase cycle|Signaling downstream of RAS mutants|Signaling by RAF1 mutants|Leishmania infection|Leishmania infection|Sensory processing of sound|Sensory processing of sound by inner hair cells of the cochlea|Sensory processing of sound by outer hair cells of the cochlea|Parasite infection|Parasite infection|Leishmania phagocytosis|Leishmania phagocytosis|FCGR3A-mediated phagocytosis|FCGR3A-mediated phagocytosis|Nervous system development|Nervous system development|RHOBTB GTPase Cycle|Sensory Perception|Signaling by Rho GTPases, Miro GTPases and RHOBTB3|Signaling by Rho GTPases, Miro GTPases and RHOBTB3|Parasitic Infection Pathways|Parasitic Infection Pathways"]
["ACTG2",1.65221305905554,1.62277424430838,1.71976075210212,2.65242985345859,1.86015373415109,3.00183893899672,2.27873892870789,2.51828436286836,2.23995536638924,2.83665264256428,2.88806149549599,1.86101252388984,1.33213823495951,1.96897859374322,2.12110555027972,1.37924418822045,1.6748344469807,1.96076823138585,0.597525865816943,1.32975913043395,1.71199844897496,1.14372598198109,0.496421136650147,1.52644045997181,1.45999430549554,1.53577133207205,0.921057177169901,1.72210529531061,72,"actin gamma 2%2C smooth muscle","protein_coding","hsa04814,hsa04270","Motor proteins|Vascular smooth muscle contraction","GO:0005524,GO:0005615,GO:0005737,GO:0005829,GO:0005856,GO:0010628,GO:0016787,GO:0030027,GO:0030175,GO:0032982,GO:0044297,GO:0070062,GO:0071944,GO:0072562,GO:0090131","ATP binding|extracellular space|cytoplasm|cytosol|cytoskeleton|positive regulation of gene expression|hydrolase activity|lamellipodium|filopodium|myosin filament|cell body|extracellular exosome|cell periphery|blood microparticle|mesenchyme migration","WP2636,WP4534,WP5087","Common pathways underlying drug addiction|Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms|Pleural mesothelioma","R-HSA-397014,R-HSA-445355","Muscle contraction|Smooth Muscle Contraction"]
["ACTL10",0.595999705138034,0.76125846735528,0.60750692887915,0.702249468918041,0.399350279020364,0.783543734071524,0.810262270686327,0.684624387505717,0.479595929220789,0.557623418642535,0.816733330901477,0.599625222740115,0.4534323480156,0.600682052024046,0.617622265149024,0.581243918444275,0.622133409661191,0.724772761995931,0.661002766070607,0.786001311249438,0.562535344701437,0.453215749150974,0.823736083825504,0.615548273868578,0.877890664010431,0.825190083817279,1.10404125360785,0.944520350088641,170487,"actin like 10","protein_coding"]
["ACTL6A",30.2442499011613,26.0442468307361,23.9768887332597,25.7302484691721,25.2325722453949,22.8644481417896,25.7052660689584,21.5273379497574,26.772162169264,19.5877427151833,23.8179872358719,26.3644770816879,24.3681913716937,21.1865085306956,25.6622475806583,20.9091277489803,38.1393448419222,30.5017069730857,40.0292763166083,34.3850520396395,36.8397020147841,32.9513958726915,48.956048393898,43.2970868947152,35.7176630015841,32.4811599479474,51.9643508530189,33.336270802404,86,"actin like 6A","protein_coding","hsa03082,hsa04714,hsa05225","ATP-dependent chromatin remodeling|Thermogenesis|Hepatocellular carcinoma","GO:0000723,GO:0000776,GO:0000785,GO:0000786,GO:0001825,GO:0003407,GO:0003682,GO:0003713,GO:0005515,GO:0005634,GO:0005654,GO:0005886,GO:0006275,GO:0006281,GO:0006282,GO:0006310,GO:0006338,GO:0006355,GO:0006357,GO:0007165,GO:0007399,GO:0008284,GO:0016363,GO:0016514,GO:0016586,GO:0021510,GO:0030071,GO:0031011,GO:0031492,GO:0032991,GO:0033044,GO:0035060,GO:0035267,GO:0042981,GO:0043967,GO:0045582,GO:0045596,GO:0045597,GO:0045663,GO:0045739,GO:0045893,GO:0045995,GO:0051726,GO:0060382,GO:0070316,GO:0071564,GO:0140288,GO:1902459,GO:1904507,GO:1905168,GO:2000045,GO:2000779,GO:2000781,GO:2000819","telomere maintenance|kinetochore|chromatin|nucleosome|blastocyst formation|neural retina development|chromatin binding|transcription coactivator activity|protein binding|nucleus|nucleoplasm|plasma membrane|regulation of DNA replication|DNA repair|regulation of DNA repair|DNA recombination|chromatin remodeling|regulation of DNA-templated transcription|regulation of transcription by RNA polymerase II|signal transduction|nervous system development|positive regulation of cell population proliferation|nuclear matrix|SWI/SNF complex|RSC-type complex|spinal cord development|regulation of mitotic metaphase/anaphase transition|Ino80 complex|nucleosomal DNA binding|protein-containing complex|regulation of chromosome organization|brahma complex|NuA4 histone acetyltransferase complex|regulation of apoptotic process|histone H4 acetylation|positive regulation of T cell differentiation|negative regulation of cell differentiation|positive regulation of cell differentiation|positive regulation of myoblast differentiation|positive regulation of DNA repair|positive regulation of DNA-templated transcription|regulation of embryonic development|regulation of cell cycle|regulation of DNA strand elongation|regulation of G0 to G1 transition|npBAF complex|GBAF complex|positive regulation of stem cell population maintenance|positive regulation of telomere maintenance in response to DNA damage|positive regulation of double-strand break repair via homologous recombination|regulation of G1/S transition of mitotic cell cycle|regulation of double-strand break repair|positive regulation of double-strand break repair|regulation of nucleotide-excision repair","WP3959,WP4204,WP4321,WP5351,WP2263,WP2361","DNA IR-double strand breaks and cellular response via ATM|Tumor suppressor activity of SMARCB1|Thermogenesis|Kleefstra syndrome|Androgen receptor network in prostate cancer|Gastric cancer network 1","R-HSA-212436,R-HSA-3214847,R-HSA-3214858,R-HSA-3247509,R-HSA-3247509,R-HSA-392499,R-HSA-4839726,R-HSA-4839726,R-HSA-5688426,R-HSA-5689603,R-HSA-5696394,R-HSA-5696398,R-HSA-5696399,R-HSA-597592,R-HSA-73857,R-HSA-73894,R-HSA-74160,R-HSA-8878171,R-HSA-8939243","Generic Transcription Pathway|HATs acetylate histones|RMTs methylate histone arginines|Chromatin modifying enzymes|Chromatin modifying enzymes|Metabolism of proteins|Chromatin organization|Chromatin organization|Deubiquitination|UCH proteinases|DNA Damage Recognition in GG-NER|Nucleotide Excision Repair|Global Genome Nucleotide Excision Repair (GG-NER)|Post-translational protein modification|RNA Polymerase II Transcription|DNA Repair|Gene expression (Transcription)|Transcriptional regulation by RUNX1|RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"]
["ACTL6B",0,0,0,0,0,0,0,0,0,0.0170356235855938,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,51412,"actin like 6B","protein_coding","hsa03082,hsa04714,hsa05225","ATP-dependent chromatin remodeling|Thermogenesis|Hepatocellular carcinoma","GO:0000776,GO:0000785,GO:0003682,GO:0003713,GO:0005200,GO:0005634,GO:0006325,GO:0006338,GO:0006357,GO:0007010,GO:0007399,GO:0008284,GO:0016358,GO:0016363,GO:0016514,GO:0016586,GO:0030071,GO:0035060,GO:0035267,GO:0042551,GO:0043967,GO:0045582,GO:0045596,GO:0045597,GO:0045663,GO:0045893,GO:0070316,GO:0071565,GO:0140092,GO:0140288,GO:1902459,GO:2000045,GO:2000781,GO:2000819","kinetochore|chromatin|chromatin binding|transcription coactivator activity|structural constituent of cytoskeleton|nucleus|chromatin organization|chromatin remodeling|regulation of transcription by RNA polymerase II|cytoskeleton organization|nervous system development|positive regulation of cell population proliferation|dendrite development|nuclear matrix|SWI/SNF complex|RSC-type complex|regulation of mitotic metaphase/anaphase transition|brahma complex|NuA4 histone acetyltransferase complex|neuron maturation|histone H4 acetylation|positive regulation of T cell differentiation|negative regulation of cell differentiation|positive regulation of cell differentiation|positive regulation of myoblast differentiation|positive regulation of DNA-templated transcription|regulation of G0 to G1 transition|nBAF complex|bBAF complex|GBAF complex|positive regulation of stem cell population maintenance|regulation of G1/S transition of mitotic cell cycle|positive regulation of double-strand break repair|regulation of nucleotide-excision repair","WP4204,WP4321,WP4746,WP5351,WP4312,WP2263","Tumor suppressor activity of SMARCB1|Thermogenesis|Thyroid hormones production and peripheral downstream signaling effects|Kleefstra syndrome|Rett syndrome causing genes|Androgen receptor network in prostate cancer","R-HSA-212436,R-HSA-3214858,R-HSA-3247509,R-HSA-4839726,R-HSA-73857,R-HSA-74160,R-HSA-8878171,R-HSA-8939243","Generic Transcription Pathway|RMTs methylate histone arginines|Chromatin modifying enzymes|Chromatin organization|RNA Polymerase II Transcription|Gene expression (Transcription)|Transcriptional regulation by RUNX1|RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"]
["ACTL7B",0,0,0,0,0,0.018093824029339,0,0,0,0,0,0,0.0183238896892856,0,0,0,0,0,0.0178080836429043,0,0,0.0183151366002755,0,0.0188245062599532,0,0,0,0,10880,"actin like 7B","protein_coding",null,null,"GO:0005200,GO:0005515,GO:0005634,GO:0005737,GO:0007010,GO:0015629","structural constituent of cytoskeleton|protein binding|nucleus|cytoplasm|cytoskeleton organization|actin cytoskeleton"]
["ACTL8",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.0133086910178284,0,81569,"actin like 8","protein_coding",null,null,"GO:0001725,GO:0005515,GO:0005865,GO:0005884,GO:0030240,GO:0030855","stress fiber|protein binding|striated muscle thin filament|actin filament|skeletal muscle thin filament assembly|epithelial cell differentiation"]
["ACTN1",190.311206368841,220.583384966398,178.532903684939,201.873697010871,200.797584250688,211.252426139342,173.355975410352,183.510046422158,184.387091040876,245.133542779395,187.31595582983,189.813945850681,184.485854432786,180.815293007533,167.206888589414,181.40967400829,187.266847235345,189.574580972542,153.065297060691,189.376406754282,204.893435765661,191.532163787318,145.910080694841,168.29912317993,191.184588229299,187.790843580377,139.61212185356,186.43162769483,87,"actinin alpha 1","protein_coding","hsa04510,hsa04520,hsa04530,hsa04810,hsa04670,hsa05203,hsa05131,hsa05146,hsa05322","Focal adhesion|Adherens junction|Tight junction|Regulation of actin cytoskeleton|Leukocyte transendothelial migration|Viral carcinogenesis|Shigellosis|Amoebiasis|Systemic lupus erythematosus","GO:0001725,GO:0001726,GO:0003725,GO:0005178,GO:0005509,GO:0005515,GO:0005576,GO:0005615,GO:0005737,GO:0005829,GO:0005884,GO:0005886,GO:0005903,GO:0005911,GO:0005916,GO:0005925,GO:0007015,GO:0017166,GO:0030018,GO:0030036,GO:0030054,GO:0030168,GO:0030220,GO:0030374,GO:0030864,GO:0031093,GO:0031143,GO:0036344,GO:0042803,GO:0042981,GO:0042995,GO:0044325,GO:0045893,GO:0048041,GO:0051015,GO:0051017,GO:0051639,GO:0055001,GO:0070062,GO:0070527,GO:0098978,GO:0099173,GO:0099186","stress fiber|ruffle|double-stranded RNA binding|integrin binding|calcium ion binding|protein binding|extracellular region|extracellular space|cytoplasm|cytosol|actin filament|plasma membrane|brush border|cell-cell junction|fascia adherens|focal adhesion|actin filament organization|vinculin binding|Z disc|actin cytoskeleton organization|cell junction|platelet activation|platelet formation|nuclear receptor coactivator activity|cortical actin cytoskeleton|platelet alpha granule lumen|pseudopodium|platelet morphogenesis|protein homodimerization activity|regulation of apoptotic process|cell projection|transmembrane transporter binding|positive regulation of DNA-templated transcription|focal adhesion assembly|actin filament binding|actin filament bundle assembly|actin filament network formation|muscle cell development|extracellular exosome|platelet aggregation|glutamatergic synapse|postsynapse organization|structural constituent of postsynapse","WP306,WP2118,WP4560,WP51,WP4217","Focal adhesion|Arrhythmogenic right ventricular cardiomyopathy|MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement|Regulation of actin cytoskeleton|Ebola virus infection in host","R-HSA-109582,R-HSA-114608,R-HSA-1474244,R-HSA-1500931,R-HSA-1500931,R-HSA-162582,R-HSA-194315,R-HSA-3000170,R-HSA-3000171,R-HSA-373753,R-HSA-446353,R-HSA-446388,R-HSA-446728,R-HSA-76002,R-HSA-76005,R-HSA-9012999,R-HSA-9013405,R-HSA-9013418,R-HSA-9035034,R-HSA-9706574,R-HSA-9716542","Hemostasis|Platelet degranulation |Extracellular matrix organization|Cell-Cell communication|Cell-Cell communication|Signal Transduction|Signaling by Rho GTPases|Syndecan interactions|Non-integrin membrane-ECM interactions|Nephrin family interactions|Cell-extracellular matrix interactions|Regulation of cytoskeletal remodeling and cell spreading by IPP complex components|Cell junction organization|Platelet activation, signaling and aggregation|Response to elevated platelet cytosolic Ca2+|RHO GTPase cycle|RHOD GTPase cycle|RHOBTB2 GTPase cycle|RHOF GTPase cycle|RHOBTB GTPase Cycle|Signaling by Rho GTPases, Miro GTPases and RHOBTB3"]
["ACTN1-DT",0.135006086320082,0.0856087915194408,0.253497092105007,0.38843608276101,0.131922264542829,0.0845183967180146,0.251918918687313,0,0.0452659406127182,0.0433427217770368,0.296252644594561,0.0452757799951157,0.085593060685511,0.343231399487096,0,0.12800627753162,0.0865334493887766,0.166555169084642,0.0831836695039169,0,0,0,0.310988366490764,0.307760250089686,0.0446160562838228,0.0427600216924532,0.0435476367194387,0,161159,"ACTN1 divergent transcript","non_coding"]
["ACTN2",0.00531785662561513,0,0.00998518827979873,0,0,0.00499373837384994,4.96151220798648E-3,0,0.0053490428934737,0.00512177753885284,0.0200045468660646,0,0,0,0.00989115382825627,0,0,0.00492042544297202,0.00491487650748138,0.0204550548383616,0.00501926810395048,0,0.00524989520412501,0,0.0105444930810849,0,0,4.99940052425785E-3,88,"actinin alpha 2","protein_coding","hsa05412","Arrhythmogenic right ventricular cardiomyopathy","GO:0005178,GO:0005509,GO:0005515,GO:0005546,GO:0005576,GO:0005829,GO:0005856,GO:0005884,GO:0005886,GO:0005925,GO:0007155,GO:0008092,GO:0008307,GO:0019904,GO:0030018,GO:0030035,GO:0030036,GO:0030054,GO:0030175,GO:0030274,GO:0030374,GO:0030864,GO:0031093,GO:0031143,GO:0031432,GO:0042391,GO:0042802,GO:0042981,GO:0042995,GO:0043197,GO:0043267,GO:0043268,GO:0044325,GO:0045214,GO:0045893,GO:0048041,GO:0051015,GO:0051373,GO:0051695,GO:0055001,GO:0055013,GO:0070062,GO:0070080,GO:0072659,GO:0086097,GO:0098839,GO:0098871,GO:0098978,GO:0099092,GO:1901017,GO:1901018,GO:2000009,GO:2001137,GO:2001259","integrin binding|calcium ion binding|protein binding|phosphatidylinositol-4,5-bisphosphate binding|extracellular region|cytosol|cytoskeleton|actin filament|plasma membrane|focal adhesion|cell adhesion|cytoskeletal protein binding|structural constituent of muscle|protein domain specific binding|Z disc|microspike assembly|actin cytoskeleton organization|cell junction|filopodium|LIM domain binding|nuclear receptor coactivator activity|cortical actin cytoskeleton|platelet alpha granule lumen|pseudopodium|titin binding|regulation of membrane potential|identical protein binding|regulation of apoptotic process|cell projection|dendritic spine|negative regulation of potassium ion transport|positive regulation of potassium ion transport|transmembrane transporter binding|sarcomere organization|positive regulation of DNA-templated transcription|focal adhesion assembly|actin filament binding|FATZ binding|actin filament uncapping|muscle cell development|cardiac muscle cell development|extracellular exosome|titin Z domain binding|protein localization to plasma membrane|phospholipase C-activating angiotensin-activated signaling pathway|postsynaptic density membrane|postsynaptic actin cytoskeleton|glutamatergic synapse|postsynaptic density, intracellular component|negative regulation of potassium ion transmembrane transporter activity|positive regulation of potassium ion transmembrane transporter activity|negative regulation of protein localization to cell surface|positive regulation of endocytic recycling|positive regulation of cation channel activity","WP5402,WP383,WP2118,WP4008","10q22q23 copy number variation|Striated muscle contraction pathway|Arrhythmogenic right ventricular cardiomyopathy|NO/cGMP/PKG mediated neuroprotection","R-HSA-109582,R-HSA-112314,R-HSA-112314,R-HSA-112315,R-HSA-112315,R-HSA-112316,R-HSA-112316,R-HSA-114608,R-HSA-1500931,R-HSA-162582,R-HSA-373753,R-HSA-390522,R-HSA-397014,R-HSA-438064,R-HSA-438066,R-HSA-438066,R-HSA-442742,R-HSA-442755,R-HSA-442755,R-HSA-442982,R-HSA-5673001,R-HSA-5683057,R-HSA-5684996,R-HSA-76002,R-HSA-76005,R-HSA-9609736,R-HSA-9617324,R-HSA-9620244","Hemostasis|Neurotransmitter receptors and postsynaptic signal transmission|Neurotransmitter receptors and postsynaptic signal transmission|Transmission across Chemical Synapses|Transmission across Chemical Synapses|Neuronal System|Neuronal System|Platelet degranulation |Cell-Cell communication|Signal Transduction|Nephrin family interactions|Striated Muscle Contraction|Muscle contraction|Post NMDA receptor activation events|Unblocking of NMDA receptors, glutamate binding and activation|Unblocking of NMDA receptors, glutamate binding and activation|CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling|Activation of NMDA receptors and postsynaptic events|Activation of NMDA receptors and postsynaptic events|Ras activation upon Ca2+ influx through NMDA receptor|RAF/MAP kinase cascade|MAPK family signaling cascades|MAPK1/MAPK3 signaling|Platelet activation, signaling and aggregation|Response to elevated platelet cytosolic Ca2+|Assembly and cell surface presentation of NMDA receptors|Negative regulation of NMDA receptor-mediated neuronal transmission|Long-term potentiation"]
["ACTN3",0,0,0.00772982886229379,0,0,0,0.0230451179434485,0,0.00828170385675571,0.0158596764474313,0,0.0165670080739611,0.00782990888066908,0.0156991148665829,0,0,0,0.0076180930270083,0.00760950183763687,0.0079174307403524,0.0466267624048717,0.00782616863279946,0.0162563951067255,0.0402191268443411,0.0163256064227305,0.0469393762867064,0.0159346575411996,0.0619229352656397,89,"actinin alpha 3","protein_coding","hsa05412","Arrhythmogenic right ventricular cardiomyopathy","GO:0005178,GO:0005509,GO:0005515,GO:0005829,GO:0005884,GO:0005886,GO:0005903,GO:0005925,GO:0008307,GO:0014728,GO:0014732,GO:0014883,GO:0014894,GO:0030018,GO:0030036,GO:0030054,GO:0030864,GO:0031143,GO:0031448,GO:0042802,GO:0042981,GO:0042995,GO:0044325,GO:0045820,GO:0048041,GO:0048633,GO:0048743,GO:0051015,GO:0055001,GO:0060349,GO:0070062,GO:0070885,GO:0090324,GO:0120163,GO:1900159,GO:1901078,GO:1903715,GO:1904025","integrin binding|calcium ion binding|protein binding|cytosol|actin filament|plasma membrane|brush border|focal adhesion|structural constituent of muscle|regulation of the force of skeletal muscle contraction|skeletal muscle atrophy|transition between fast and slow fiber|response to denervation involved in regulation of muscle adaptation|Z disc|actin cytoskeleton organization|cell junction|cortical actin cytoskeleton|pseudopodium|positive regulation of fast-twitch skeletal muscle fiber contraction|identical protein binding|regulation of apoptotic process|cell projection|transmembrane transporter binding|negative regulation of glycolytic process|focal adhesion assembly|positive regulation of skeletal muscle tissue growth|positive regulation of skeletal muscle fiber development|actin filament binding|muscle cell development|bone morphogenesis|extracellular exosome|negative regulation of calcineurin-NFAT signaling cascade|negative regulation of oxidative phosphorylation|negative regulation of cold-induced thermogenesis|positive regulation of bone mineralization involved in bone maturation|negative regulation of relaxation of muscle|regulation of aerobic respiration|positive regulation of glucose catabolic process to lactate via pyruvate","WP383,WP2118","Striated muscle contraction pathway|Arrhythmogenic right ventricular cardiomyopathy","R-HSA-1500931,R-HSA-373753,R-HSA-390522,R-HSA-397014","Cell-Cell communication|Nephrin family interactions|Striated Muscle Contraction|Muscle contraction"]
["ACTN4",140.699700641518,153.958670860132,121.802608427765,135.532473709108,140.887240178343,141.748347563594,117.786857529395,123.097810798799,157.460144949278,219.578771837723,153.90900206459,157.373064055438,146.252806197376,132.170747308982,123.273616553002,136.824429674973,139.976756796833,148.301360658144,125.899947839703,147.973303765772,154.318551643374,145.096636793081,116.890758573392,130.473835368389,148.255762406093,138.148183300171,113.364889852938,140.001768463779,81,"actinin alpha 4","protein_coding","hsa04510,hsa04520,hsa04530,hsa04810,hsa04670,hsa05203,hsa05131,hsa05146,hsa05322","Focal adhesion|Adherens junction|Tight junction|Regulation of actin cytoskeleton|Leukocyte transendothelial migration|Viral carcinogenesis|Shigellosis|Amoebiasis|Systemic lupus erythematosus","GO:0000977,GO:0001882,GO:0003713,GO:0003723,GO:0003779,GO:0005178,GO:0005509,GO:0005515,GO:0005576,GO:0005615,GO:0005634,GO:0005737,GO:0005886,GO:0005925,GO:0015031,GO:0015629,GO:0016922,GO:0030018,GO:0030036,GO:0030050,GO:0030054,GO:0030335,GO:0030374,GO:0030864,GO:0031093,GO:0031143,GO:0031490,GO:0032417,GO:0032991,GO:0033209,GO:0035357,GO:0042803,GO:0042974,GO:0042981,GO:0042995,GO:0044325,GO:0045944,GO:0048384,GO:0048471,GO:0051015,GO:0055001,GO:0070062,GO:1900025,GO:1901224,GO:1990904","RNA polymerase II transcription regulatory region sequence-specific DNA binding|nucleoside binding|transcription coactivator activity|RNA binding|actin binding|integrin binding|calcium ion binding|protein binding|extracellular region|extracellular space|nucleus|cytoplasm|plasma membrane|focal adhesion|protein transport|actin cytoskeleton|nuclear receptor binding|Z disc|actin cytoskeleton organization|vesicle transport along actin filament|cell junction|positive regulation of cell migration|nuclear receptor coactivator activity|cortical actin cytoskeleton|platelet alpha granule lumen|pseudopodium|chromatin DNA binding|positive regulation of sodium:proton antiporter activity|protein-containing complex|tumor necrosis factor-mediated signaling pathway|peroxisome proliferator activated receptor signaling pathway|protein homodimerization activity|nuclear retinoic acid receptor binding|regulation of apoptotic process|cell projection|transmembrane transporter binding|positive regulation of transcription by RNA polymerase II|retinoic acid receptor signaling pathway|perinuclear region of cytoplasm|actin filament binding|muscle cell development|extracellular exosome|negative regulation of substrate adhesion-dependent cell spreading|positive regulation of non-canonical NF-kappaB signal transduction|ribonucleoprotein complex","WP306,WP2572,WP383,WP2118,WP5202,WP4758,WP4217","Focal adhesion|Primary focal segmental glomerulosclerosis (FSGS)|Striated muscle contraction pathway|Arrhythmogenic right ventricular cardiomyopathy|Alstrom syndrome|Nephrotic syndrome|Ebola virus infection in host","R-HSA-109582,R-HSA-114608,R-HSA-1500931,R-HSA-373753,R-HSA-76002,R-HSA-76005","Hemostasis|Platelet degranulation |Cell-Cell communication|Nephrin family interactions|Platelet activation, signaling and aggregation|Response to elevated platelet cytosolic Ca2+"]
["ACTR10",38.4089999708424,30.463795064376,30.7044395725017,32.0256941422487,35.0483439882601,29.1170226137607,31.103464704973,32.7449322707673,36.5803029828483,25.0110166348297,32.259862244347,34.6455152118492,37.2231676199342,32.3226936668595,34.3062108075448,32.7873842338862,44.0232956555531,34.5116675641,42.0729575896944,35.6222843137851,42.6942457789783,36.2665492156502,50.1448484563611,45.0489654551823,43.2067289266845,39.7854275609427,48.8731953608024,38.9780021646282,55860,"actin related protein 10","protein_coding","hsa04814,hsa05132,hsa05014,hsa05016,hsa05022","Motor proteins|Salmonella infection|Amyotrophic lateral sclerosis|Huntington disease|Pathways of neurodegeneration - multiple diseases","GO:0005515,GO:0005576,GO:0005829,GO:0005869,GO:0035578,GO:0098958,GO:1904115,GO:1904813","protein binding|extracellular region|cytosol|dynactin complex|azurophil granule lumen|retrograde axonal transport of mitochondrion|axon cytoplasm|ficolin-1-rich granule lumen",null,null,"R-HSA-1280218,R-HSA-168249,R-HSA-168256,R-HSA-199977,R-HSA-199991,R-HSA-2132295,R-HSA-2262752,R-HSA-3371497,R-HSA-392499,R-HSA-446203,R-HSA-5653656,R-HSA-597592,R-HSA-6798695,R-HSA-6807878,R-HSA-6811436,R-HSA-6811442,R-HSA-8856688,R-HSA-8953897,R-HSA-948021","Adaptive Immune System|Innate Immune System|Immune System|ER to Golgi Anterograde Transport|Membrane Trafficking|MHC class II antigen presentation|Cellular responses to stress|HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand|Metabolism of proteins|Asparagine N-linked glycosylation|Vesicle-mediated transport|Post-translational protein modification|Neutrophil degranulation|COPI-mediated anterograde transport|COPI-independent Golgi-to-ER retrograde traffic|Intra-Golgi and retrograde Golgi-to-ER traffic|Golgi-to-ER retrograde transport|Cellular responses to stimuli|Transport to the Golgi and subsequent modification"]
["ACTR1A",61.6373387940841,58.7722957811627,60.8720417473092,67.3263283878774,59.1590400644403,58.9360667613116,55.694154427834,60.0397473588703,63.0239770505037,74.0888540006143,73.0514007917477,70.5029166576028,58.0821202056859,63.0590063597615,60.387369246603,58.7215303992753,77.3656737952993,79.9278099142,80.3658741381366,75.6857755121765,69.9358763523737,76.479305458896,66.6045244478846,68.1744726755208,69.2961766732877,81.3017143615268,68.1160438793762,80.6823572189901,10121,"actin related protein 1A","protein_coding","hsa04814,hsa05132,hsa05014,hsa05016,hsa05022","Motor proteins|Salmonella infection|Amyotrophic lateral sclerosis|Huntington disease|Pathways of neurodegeneration - multiple diseases","GO:0005515,GO:0005524,GO:0005737,GO:0005813,GO:0005829,GO:0005869,GO:0005875,GO:0015630,GO:0016192,GO:0070062,GO:0099738","protein binding|ATP binding|cytoplasm|centrosome|cytosol|dynactin complex|microtubule associated complex|microtubule cytoskeleton|vesicle-mediated transport|extracellular exosome|cell cortex region",null,null,"R-HSA-1280218,R-HSA-1640170,R-HSA-168256,R-HSA-1852241,R-HSA-199977,R-HSA-199991,R-HSA-2132295,R-HSA-2262752,R-HSA-2565942,R-HSA-3371497,R-HSA-380259,R-HSA-380270,R-HSA-380284,R-HSA-380287,R-HSA-380320,R-HSA-392499,R-HSA-446203,R-HSA-453274,R-HSA-5617833,R-HSA-5620912,R-HSA-5653656,R-HSA-597592,R-HSA-6807878,R-HSA-6811436,R-HSA-6811442,R-HSA-68877,R-HSA-68886,R-HSA-69275,R-HSA-69278,R-HSA-8854518,R-HSA-8856688,R-HSA-8953897,R-HSA-948021","Adaptive Immune System|Cell Cycle|Immune System|Organelle biogenesis and maintenance|ER to Golgi Anterograde Transport|Membrane Trafficking|MHC class II antigen presentation|Cellular responses to stress|Regulation of PLK1 Activity at G2/M Transition|HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand|Loss of Nlp from mitotic centrosomes|Recruitment of mitotic centrosome proteins and complexes|Loss of proteins required for interphase microtubule organization from the centrosome|Centrosome maturation|Recruitment of NuMA to mitotic centrosomes|Metabolism of proteins|Asparagine N-linked glycosylation|Mitotic G2-G2/M phases|Cilium Assembly|Anchoring of the basal body to the plasma membrane|Vesicle-mediated transport|Post-translational protein modification|COPI-mediated anterograde transport|COPI-independent Golgi-to-ER retrograde traffic|Intra-Golgi and retrograde Golgi-to-ER traffic|Mitotic Prometaphase|M Phase|G2/M Transition|Cell Cycle, Mitotic|AURKA Activation by TPX2|Golgi-to-ER retrograde transport|Cellular responses to stimuli|Transport to the Golgi and subsequent modification"]
["ACTR1B",33.7649649068339,33.3501408537936,35.756601764985,35.2619309354156,31.8306979539893,35.0196967556419,38.3451023589071,36.3061943838467,32.000049098235,37.3943728469513,35.5051841918884,33.4201891362356,33.4561790838082,33.4276869091766,32.1890014444175,31.9634831873627,40.8957116231982,42.5118984503866,46.0711628549527,42.7284778054012,41.7061428591845,41.0842536095303,43.9506190989954,42.6877877287287,39.7260903728141,43.4324970216713,44.67866273056,45.6639158696529,10120,"actin related protein 1B","protein_coding","hsa04814,hsa05132,hsa05014,hsa05016,hsa05022","Motor proteins|Salmonella infection|Amyotrophic lateral sclerosis|Huntington disease|Pathways of neurodegeneration - multiple diseases","GO:0005515,GO:0005524,GO:0005576,GO:0005737,GO:0005813,GO:0005829,GO:0005869,GO:0015630,GO:0016020,GO:0034774,GO:0070062,GO:1904813","protein binding|ATP binding|extracellular region|cytoplasm|centrosome|cytosol|dynactin complex|microtubule cytoskeleton|membrane|secretory granule lumen|extracellular exosome|ficolin-1-rich granule lumen",null,null,"R-HSA-1280218,R-HSA-168249,R-HSA-168256,R-HSA-2132295,R-HSA-6798695","Adaptive Immune System|Innate Immune System|Immune System|MHC class II antigen presentation|Neutrophil degranulation"]
["ACTR2",99.7692252664066,82.6779977584803,69.1124202101355,57.9743069454226,91.4703989368235,74.5601468070791,73.0459732153683,68.3239952993447,88.739001960989,52.9362760472308,54.2324753502278,74.0842533575951,99.1386696068882,63.673468734695,85.9267841598474,85.1010763571405,88.6683740354529,76.2433914119633,82.1857173424869,101.311543815865,89.6455529734741,85.1869553877038,123.122991725323,104.925894625363,95.9722265933071,72.2404334042563,103.419812511601,68.3125327419448,10097,"actin related protein 2","protein_coding","hsa04144,hsa04530,hsa04810,hsa04666,hsa05130,hsa05132,hsa05131,hsa05135,hsa05100","Endocytosis|Tight junction|Regulation of actin cytoskeleton|Fc gamma R-mediated phagocytosis|Pathogenic Escherichia coli infection|Salmonella infection|Shigellosis|Yersinia infection|Bacterial invasion of epithelial cells","GO:0005200,GO:0005515,GO:0005524,GO:0005576,GO:0005634,GO:0005737,GO:0005829,GO:0005885,GO:0005925,GO:0007163,GO:0008356,GO:0010592,GO:0015629,GO:0016020,GO:0016344,GO:0016482,GO:0030478,GO:0033206,GO:0034314,GO:0035578,GO:0035861,GO:0042995,GO:0045944,GO:0051015,GO:0051653,GO:0060271,GO:0070062,GO:0071346,GO:1904813,GO:1905168,GO:2001032","structural constituent of cytoskeleton|protein binding|ATP binding|extracellular region|nucleus|cytoplasm|cytosol|Arp2/3 protein complex|focal adhesion|establishment or maintenance of cell polarity|asymmetric cell division|positive regulation of lamellipodium assembly|actin cytoskeleton|membrane|meiotic chromosome movement towards spindle pole|cytosolic transport|actin cap|meiotic cytokinesis|Arp2/3 complex-mediated actin nucleation|azurophil granule lumen|site of double-strand break|cell projection|positive regulation of transcription by RNA polymerase II|actin filament binding|spindle localization|cilium assembly|extracellular exosome|cellular response to type II interferon|ficolin-1-rich granule lumen|positive regulation of double-strand break repair via homologous recombination|regulation of double-strand break repair via nonhomologous end joining","WP3680,WP3931","Physico-chemical features and toxicity-associated pathways|Embryonic stem cell pluripotency pathways","R-HSA-1266738,R-HSA-162582,R-HSA-162582,R-HSA-1643685,R-HSA-1643685,R-HSA-168249,R-HSA-168249,R-HSA-168256,R-HSA-168256,R-HSA-194315,R-HSA-194315,R-HSA-195258,R-HSA-195258,R-HSA-199991,R-HSA-2029480,R-HSA-2029480,R-HSA-2029482,R-HSA-2029482,R-HSA-2682334,R-HSA-3928662,R-HSA-422475,R-HSA-5653656,R-HSA-5663205,R-HSA-5663205,R-HSA-5663213,R-HSA-5663213,R-HSA-6798695,R-HSA-8856828,R-HSA-9658195,R-HSA-9658195,R-HSA-9664407,R-HSA-9664407,R-HSA-9664417,R-HSA-9664417,R-HSA-9664422,R-HSA-9664422,R-HSA-9675108,R-HSA-9716542,R-HSA-9716542,R-HSA-9824443,R-HSA-9824443","Developmental Biology|Signal Transduction|Signal Transduction|Disease|Disease|Innate Immune System|Innate Immune System|Immune System|Immune System|Signaling by Rho GTPases|Signaling by Rho GTPases|RHO GTPase Effectors|RHO GTPase Effectors|Membrane Trafficking|Fcgamma receptor (FCGR) dependent phagocytosis|Fcgamma receptor (FCGR) dependent phagocytosis|Regulation of actin dynamics for phagocytic cup formation|Regulation of actin dynamics for phagocytic cup formation|EPH-Ephrin signaling|EPHB-mediated forward signaling|Axon guidance|Vesicle-mediated transport|Infectious disease|Infectious disease|RHO GTPases Activate WASPs and WAVEs|RHO GTPases Activate WASPs and WAVEs|Neutrophil degranulation|Clathrin-mediated endocytosis|Leishmania infection|Leishmania infection|Parasite infection|Parasite infection|Leishmania phagocytosis|Leishmania phagocytosis|FCGR3A-mediated phagocytosis|FCGR3A-mediated phagocytosis|Nervous system development|Signaling by Rho GTPases, Miro GTPases and RHOBTB3|Signaling by Rho GTPases, Miro GTPases and RHOBTB3|Parasitic Infection Pathways|Parasitic Infection Pathways"]
["ACTR3",62.2222711198145,54.1807166554501,47.3813961057643,46.8592319672518,57.8050951011015,52.1931748576272,48.7135464221393,46.5879927855674,53.1712593673698,38.3988793528698,38.8274817347289,48.0552179964585,57.3704177995022,39.5703216551669,46.1205327030202,45.0540877755467,60.1827933786361,50.0932691946929,53.2751654402891,57.1616817154193,61.1225384324662,53.7815464453162,67.5355894425409,63.7731061920705,59.3279602989445,51.7977912463566,59.1363527169272,49.1229774862167,10096,"actin related protein 3","protein_coding","hsa04144,hsa04530,hsa04810,hsa04666,hsa05130,hsa05132,hsa05131,hsa05135,hsa05100","Endocytosis|Tight junction|Regulation of actin cytoskeleton|Fc gamma R-mediated phagocytosis|Pathogenic Escherichia coli infection|Salmonella infection|Shigellosis|Yersinia infection|Bacterial invasion of epithelial cells","GO:0005200,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0005885,GO:0005903,GO:0005911,GO:0005925,GO:0007163,GO:0008356,GO:0010592,GO:0015629,GO:0016020,GO:0016344,GO:0030027,GO:0033206,GO:0034314,GO:0035861,GO:0045944,GO:0051015,GO:0051653,GO:0060271,GO:0070062,GO:0070358,GO:0071346","structural constituent of cytoskeleton|protein binding|ATP binding|nucleus|cytoplasm|cytosol|Arp2/3 protein complex|brush border|cell-cell junction|focal adhesion|establishment or maintenance of cell polarity|asymmetric cell division|positive regulation of lamellipodium assembly|actin cytoskeleton|membrane|meiotic chromosome movement towards spindle pole|lamellipodium|meiotic cytokinesis|Arp2/3 complex-mediated actin nucleation|site of double-strand break|positive regulation of transcription by RNA polymerase II|actin filament binding|spindle localization|cilium assembly|extracellular exosome|actin polymerization-dependent cell motility|cellular response to type II interferon","WP3680","Physico-chemical features and toxicity-associated pathways","R-HSA-1266738,R-HSA-162582,R-HSA-162582,R-HSA-1643685,R-HSA-1643685,R-HSA-168249,R-HSA-168249,R-HSA-168256,R-HSA-168256,R-HSA-194315,R-HSA-194315,R-HSA-195258,R-HSA-195258,R-HSA-199991,R-HSA-2029480,R-HSA-2029480,R-HSA-2029482,R-HSA-2029482,R-HSA-2682334,R-HSA-3928662,R-HSA-422475,R-HSA-5653656,R-HSA-5663205,R-HSA-5663205,R-HSA-5663213,R-HSA-5663213,R-HSA-8856828,R-HSA-9658195,R-HSA-9658195,R-HSA-9664407,R-HSA-9664407,R-HSA-9664417,R-HSA-9664417,R-HSA-9664422,R-HSA-9664422,R-HSA-9675108,R-HSA-9716542,R-HSA-9716542,R-HSA-9824443,R-HSA-9824443","Developmental Biology|Signal Transduction|Signal Transduction|Disease|Disease|Innate Immune System|Innate Immune System|Immune System|Immune System|Signaling by Rho GTPases|Signaling by Rho GTPases|RHO GTPase Effectors|RHO GTPase Effectors|Membrane Trafficking|Fcgamma receptor (FCGR) dependent phagocytosis|Fcgamma receptor (FCGR) dependent phagocytosis|Regulation of actin dynamics for phagocytic cup formation|Regulation of actin dynamics for phagocytic cup formation|EPH-Ephrin signaling|EPHB-mediated forward signaling|Axon guidance|Vesicle-mediated transport|Infectious disease|Infectious disease|RHO GTPases Activate WASPs and WAVEs|RHO GTPases Activate WASPs and WAVEs|Clathrin-mediated endocytosis|Leishmania infection|Leishmania infection|Parasite infection|Parasite infection|Leishmania phagocytosis|Leishmania phagocytosis|FCGR3A-mediated phagocytosis|FCGR3A-mediated phagocytosis|Nervous system development|Signaling by Rho GTPases, Miro GTPases and RHOBTB3|Signaling by Rho GTPases, Miro GTPases and RHOBTB3|Parasitic Infection Pathways|Parasitic Infection Pathways"]
["ACTR3-AS1",0.365508003189737,0.564945474204988,0.0428939994833048,0.438179309931911,0.491093672922429,0.171615320793527,0.25576174965034,0.179208004203646,0.413607942107057,0.0440038819397374,0.429673932474921,0.321764992405966,0.173797435086851,0.217791957937257,0.169960199170952,0.69311421687178,0.307487079056898,0.211369801444281,0.380036578216624,0.131805092765663,0.388108525712415,0.260571621394428,0.180418432472608,0.580273381948762,0.271779841159422,0.0434122932097957,0.221059613516472,0.257714860245386,101060091,"ACTR3 antisense RNA 1","non_coding"]
["ACTR3B",0.874472458524255,0.698227596725189,0.67411239366545,0.580913611932053,0.615395115297681,0.59139609989228,0.662430543551216,0.735566186896885,0.568916083066899,0.772687212632294,0.694128007581509,0.694147776984641,0.621804290636253,0.527756583787246,0.630458759647905,0.589520974078537,0.636349216543135,0.590136936710953,0.656204032129002,0.590180839481965,0.810227884531243,0.667262398536079,0.788055362969081,0.627035339468442,0.672102380010069,0.632708332882052,0.593900336670595,0.795707414482842,57180,"actin related protein 3B","protein_coding","hsa04144,hsa04530,hsa04810,hsa04666,hsa05130,hsa05132,hsa05131,hsa05135,hsa05100","Endocytosis|Tight junction|Regulation of actin cytoskeleton|Fc gamma R-mediated phagocytosis|Pathogenic Escherichia coli infection|Salmonella infection|Shigellosis|Yersinia infection|Bacterial invasion of epithelial cells","GO:0003674,GO:0005524,GO:0005737,GO:0005856,GO:0008150,GO:0042995,GO:0051015,GO:0070062","molecular_function|ATP binding|cytoplasm|cytoskeleton|biological_process|cell projection|actin filament binding|extracellular exosome"]
["ACTR3C",0.0379073377562234,0.0175408382456503,0.0115423023200105,0.0176863831533461,0.0370414547662285,0.0384831588568209,0.0258085000692354,0.0160742993394627,0.0319464578023474,0.0197349324194786,0.0144525647159099,0.0247381176393821,0.016563303123419,0.0214886520012587,0.0123864042381628,0.0252564803856113,0.039400658419579,0.0189590943486946,0.0217783705437927,0.0137928378022421,0.0290099236276747,0.00876461878811406,0.0131485821240631,0.0200186114231116,0.0314878016470033,0.0243370196816725,0.00495705871972631,0.030821434390134,653857,"actin related protein 3C","protein_coding","hsa04144,hsa04530,hsa04810,hsa04666,hsa05130,hsa05132,hsa05131,hsa05135,hsa05100","Endocytosis|Tight junction|Regulation of actin cytoskeleton|Fc gamma R-mediated phagocytosis|Pathogenic Escherichia coli infection|Salmonella infection|Shigellosis|Yersinia infection|Bacterial invasion of epithelial cells","GO:0003674,GO:0005524,GO:0008150,GO:0051015,GO:0070062","molecular_function|ATP binding|biological_process|actin filament binding|extracellular exosome"]
["ACTR5",2.88929986620391,3.26160420552159,4.02415436848673,3.49167148581785,2.17177092747578,2.56412290255112,3.37701909726774,2.78134762707897,2.64010444047919,3.05798472843876,2.88642362962147,3.40732685883933,2.29478121003958,2.83531438605558,2.7657735984052,2.50869520486326,3.19507859476588,3.41760155597895,3.7169742545115,3.2669240307406,2.5672423222865,2.91740638794573,3.5315119556034,2.7710678370855,2.87501172109882,3.06715436321269,3.3592034870599,3.81074643172687,79913,"actin related protein 5","protein_coding","hsa03082","ATP-dependent chromatin remodeling","GO:0000723,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006275,GO:0006282,GO:0006302,GO:0006310,GO:0006338,GO:0006355,GO:0031011,GO:0033044,GO:0045739,GO:0045893,GO:0045995,GO:0051726,GO:0060382,GO:0070914,GO:1904507","telomere maintenance|protein binding|nucleus|nucleoplasm|cytoplasm|regulation of DNA replication|regulation of DNA repair|double-strand break repair|DNA recombination|chromatin remodeling|regulation of DNA-templated transcription|Ino80 complex|regulation of chromosome organization|positive regulation of DNA repair|positive regulation of DNA-templated transcription|regulation of embryonic development|regulation of cell cycle|regulation of DNA strand elongation|UV-damage excision repair|positive regulation of telomere maintenance in response to DNA damage",null,null,"R-HSA-392499,R-HSA-5688426,R-HSA-5689603,R-HSA-5696394,R-HSA-5696398,R-HSA-5696399,R-HSA-597592,R-HSA-73894","Metabolism of proteins|Deubiquitination|UCH proteinases|DNA Damage Recognition in GG-NER|Nucleotide Excision Repair|Global Genome Nucleotide Excision Repair (GG-NER)|Post-translational protein modification|DNA Repair"]
["ACTR6",12.1667661165403,10.5983881042786,11.1603420417298,9.09379731936412,13.2384789926286,11.104607933557,10.8736781474351,10.6219689538206,12.8937308582136,6.1131702653299,10.493493315785,11.1478510322343,15.3928796242653,9.70572244099436,12.1809701754702,12.9485068149045,13.1001280280495,10.8985044081477,16.293463582416,14.7889310476215,16.6541829657557,12.6565501997973,27.5156286392162,17.9208649352742,13.4471303868996,13.5660292195032,21.1593629605502,12.6345068790806,64431,"actin related protein 6","protein_coding","hsa03082","ATP-dependent chromatin remodeling","GO:0000786,GO:0000812,GO:0005515,GO:0005634,GO:0005730,GO:0005737,GO:0005856,GO:0006338,GO:0006355,GO:0007000,GO:0016479,GO:0031491,GO:0045943","nucleosome|Swr1 complex|protein binding|nucleus|nucleolus|cytoplasm|cytoskeleton|chromatin remodeling|regulation of DNA-templated transcription|nucleolus organization|negative regulation of transcription by RNA polymerase I|nucleosome binding|positive regulation of transcription by RNA polymerase I"]
["ACTR8",3.79075331998945,3.84370249976271,3.66356827696311,3.47625211467633,3.91538644405315,3.40586951535159,3.62165430760324,3.56547840219637,4.85892255934495,3.55017391390234,3.9608559543896,4.13201206649946,4.70637204725251,3.81142360693,4.36122863572817,4.26300054126464,4.18054729667381,3.81061553072251,3.87150925122267,4.20540612516268,4.15990983596334,3.95146405348324,4.32858800605811,4.19473780655288,4.24775963159285,3.7899917699076,4.29796464412343,3.78621350769896,93973,"actin related protein 8","protein_coding","hsa03082","ATP-dependent chromatin remodeling","GO:0000723,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005813,GO:0006275,GO:0006282,GO:0006302,GO:0006310,GO:0006338,GO:0006355,GO:0007049,GO:0031011,GO:0033044,GO:0045739,GO:0045893,GO:0045995,GO:0051301,GO:0051726,GO:0060382,GO:1904507","telomere maintenance|protein binding|ATP binding|nucleus|nucleoplasm|centrosome|regulation of DNA replication|regulation of DNA repair|double-strand break repair|DNA recombination|chromatin remodeling|regulation of DNA-templated transcription|cell cycle|Ino80 complex|regulation of chromosome organization|positive regulation of DNA repair|positive regulation of DNA-templated transcription|regulation of embryonic development|cell division|regulation of cell cycle|regulation of DNA strand elongation|positive regulation of telomere maintenance in response to DNA damage",null,null,"R-HSA-392499,R-HSA-5688426,R-HSA-5689603,R-HSA-5696394,R-HSA-5696398,R-HSA-5696399,R-HSA-597592,R-HSA-73894","Metabolism of proteins|Deubiquitination|UCH proteinases|DNA Damage Recognition in GG-NER|Nucleotide Excision Repair|Global Genome Nucleotide Excision Repair (GG-NER)|Post-translational protein modification|DNA Repair"]
["ACTRT3",2.0326050985282,1.88731266689941,2.09002360139478,1.87202997821898,1.71819999486651,1.49970839131507,1.89640220117756,2.04062256133146,1.4441487492547,1.80228945538936,1.44124619480666,1.20101389830251,1.96367179798908,2.0762572650751,1.47024217774752,1.49894763687635,1.50444434764694,1.91055025793801,1.55057147678516,1.67536814502853,2.07073795486164,1.34937947165357,2.24551307561284,1.84395670744938,1.98318503682658,1.67076276261038,1.45177031641518,1.88055248110438,84517,"actin related protein T3","protein_coding",null,null,"GO:0001673,GO:0005737,GO:0005856","male germ cell nucleus|cytoplasm|cytoskeleton"]
["ACVR1",18.5375332438377,17.7404800375789,16.9883369536258,16.9238924657594,19.7569031058408,18.5769057977378,15.7916639188171,16.7895630245445,17.6290620253508,16.7643956878315,14.8716545285071,17.1305504883466,18.5847118921595,17.4503189219186,17.9686585012136,18.0138597331591,13.9336809460293,13.777841913229,13.7856697019363,15.4861455300099,14.4483345336075,13.6254825330329,13.6271966791854,13.5598413669058,14.5499393040869,12.3652257712056,12.2015577064274,12.8165557871858,90,"activin A receptor type 1","protein_coding","hsa04350,hsa04060,hsa04550,hsa05418","TGF-beta signaling pathway|Cytokine-cytokine receptor interaction|Signaling pathways regulating pluripotency of stem cells|Fluid shear stress and atherosclerosis","GO:0001569,GO:0001701,GO:0001702,GO:0001707,GO:0001755,GO:0002526,GO:0003143,GO:0003148,GO:0003181,GO:0003183,GO:0003272,GO:0003274,GO:0003289,GO:0004672,GO:0004674,GO:0004675,GO:0005025,GO:0005515,GO:0005524,GO:0005886,GO:0006468,GO:0007179,GO:0007281,GO:0007368,GO:0007507,GO:0009953,GO:0009968,GO:0016361,GO:0017046,GO:0018107,GO:0030278,GO:0030335,GO:0030501,GO:0030509,GO:0032924,GO:0032926,GO:0042803,GO:0045177,GO:0045296,GO:0045669,GO:0045893,GO:0045944,GO:0046332,GO:0046872,GO:0048179,GO:0048185,GO:0050431,GO:0050731,GO:0051145,GO:0060037,GO:0060391,GO:0060412,GO:0060923,GO:0061445,GO:0062043,GO:0070724,GO:0071363,GO:0071773,GO:1990782,GO:2000017,GO:2000134,GO:2001237","branching involved in blood vessel morphogenesis|in utero embryonic development|gastrulation with mouth forming second|mesoderm formation|neural crest cell migration|acute inflammatory response|embryonic heart tube morphogenesis|outflow tract septum morphogenesis|atrioventricular valve morphogenesis|mitral valve morphogenesis|endocardial cushion formation|endocardial cushion fusion|atrial septum primum morphogenesis|protein kinase activity|protein serine/threonine kinase activity|transmembrane receptor protein serine/threonine kinase activity|transforming growth factor beta receptor activity, type I|protein binding|ATP binding|plasma membrane|protein phosphorylation|transforming growth factor beta receptor signaling pathway|germ cell development|determination of left/right symmetry|heart development|dorsal/ventral pattern formation|negative regulation of signal transduction|activin receptor activity, type I|peptide hormone binding|peptidyl-threonine phosphorylation|regulation of ossification|positive regulation of cell migration|positive regulation of bone mineralization|BMP signaling pathway|activin receptor signaling pathway|negative regulation of activin receptor signaling pathway|protein homodimerization activity|apical part of cell|cadherin binding|positive regulation of osteoblast differentiation|positive regulation of DNA-templated transcription|positive regulation of transcription by RNA polymerase II|SMAD binding|metal ion binding|activin receptor complex|activin binding|transforming growth factor beta binding|positive regulation of peptidyl-tyrosine phosphorylation|smooth muscle cell differentiation|pharyngeal system development|positive regulation of SMAD protein signal transduction|ventricular septum morphogenesis|cardiac muscle cell fate commitment|endocardial cushion cell fate commitment|positive regulation of cardiac epithelial to mesenchymal transition|BMP receptor complex|cellular response to growth factor stimulus|cellular response to BMP stimulus|protein tyrosine kinase binding|positive regulation of determination of dorsal identity|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of extrinsic apoptotic signaling pathway","WP2857,WP3931","Mesodermal commitment pathway|Embryonic stem cell pluripotency pathways"]
["ACVR1B",4.04889705431683,4.12996942397777,3.44211302156664,3.5400785863408,3.60203377897632,4.08203139327583,4.01860817663836,3.98495056159066,3.68786440087346,3.3780643168408,3.24243067436751,3.36378351678788,3.62841383093227,3.81750046728652,3.63146621652864,4.21580079961232,3.25273112248621,2.80857721056575,2.6355241753459,3.26290073914358,2.83217336738494,3.07890070395652,2.65332470793087,3.30042928404325,3.47238066501602,2.73315029181686,2.67773021709983,2.66683742683586,91,"activin A receptor type 1B","protein_coding","hsa04350,hsa04060,hsa04550","TGF-beta signaling pathway|Cytokine-cytokine receptor interaction|Signaling pathways regulating pluripotency of stem cells","GO:0000082,GO:0001701,GO:0001942,GO:0004674,GO:0004675,GO:0005515,GO:0005524,GO:0005829,GO:0005886,GO:0006355,GO:0006468,GO:0007165,GO:0007178,GO:0007399,GO:0009986,GO:0010628,GO:0010629,GO:0016361,GO:0017002,GO:0018107,GO:0019838,GO:0030308,GO:0031625,GO:0032924,GO:0032927,GO:0034711,GO:0038092,GO:0043235,GO:0045648,GO:0046332,GO:0046777,GO:0046872,GO:0048179,GO:0048185,GO:0070411,GO:0071363,GO:0097191,GO:1901165","G1/S transition of mitotic cell cycle|in utero embryonic development|hair follicle development|protein serine/threonine kinase activity|transmembrane receptor protein serine/threonine kinase activity|protein binding|ATP binding|cytosol|plasma membrane|regulation of DNA-templated transcription|protein phosphorylation|signal transduction|transmembrane receptor protein serine/threonine kinase signaling pathway|nervous system development|cell surface|positive regulation of gene expression|negative regulation of gene expression|activin receptor activity, type I|activin receptor activity|peptidyl-threonine phosphorylation|growth factor binding|negative regulation of cell growth|ubiquitin protein ligase binding|activin receptor signaling pathway|positive regulation of activin receptor signaling pathway|inhibin binding|nodal signaling pathway|receptor complex|positive regulation of erythrocyte differentiation|SMAD binding|protein autophosphorylation|metal ion binding|activin receptor complex|activin binding|I-SMAD binding|cellular response to growth factor stimulus|extrinsic apoptotic signaling pathway|positive regulation of trophoblast cell migration","WP2849","Hematopoietic stem cell differentiation","R-HSA-1181150,R-HSA-1266738,R-HSA-1433617,R-HSA-1502540,R-HSA-162582,R-HSA-9006936","Signaling by NODAL|Developmental Biology|Regulation of signaling by NODAL|Signaling by Activin|Signal Transduction|Signaling by TGFB family members"]
["ACVR1C",0.0238181711820129,0.0396463069186012,0.0139758447620664,0.0256983889522691,0.00581852856646451,0.0139790478335792,0.00833330198220128,0.0321145335564851,0.014973657183023,0.00286749396338028,0.00559990325072241,0.0209676767748531,0.0084940761018259,0,0.0332261489432942,5.64581107734634E-3,0.0314871271273828,0.0165285861964381,0,0.008589021949606951,0.0196707190338496,0.0169800371794469,0.0235137784755552,0.0174522758500163,0.0206621519768134,0.0198026033749123,0.00576210169978877,0.00559795919095715,130399,"activin A receptor type 1C","protein_coding","hsa04350,hsa04060,hsa04550","TGF-beta signaling pathway|Cytokine-cytokine receptor interaction|Signaling pathways regulating pluripotency of stem cells","GO:0001834,GO:0002021,GO:0004674,GO:0005524,GO:0005886,GO:0006468,GO:0007399,GO:0009749,GO:0016361,GO:0019838,GO:0019915,GO:0030073,GO:0030154,GO:0030262,GO:0032868,GO:0032924,GO:0038092,GO:0038100,GO:0043065,GO:0043280,GO:0046676,GO:0046872,GO:0048179,GO:0071363,GO:1901164,GO:1901383","trophectodermal cell proliferation|response to dietary excess|protein serine/threonine kinase activity|ATP binding|plasma membrane|protein phosphorylation|nervous system development|response to glucose|activin receptor activity, type I|growth factor binding|lipid storage|insulin secretion|cell differentiation|apoptotic nuclear changes|response to insulin|activin receptor signaling pathway|nodal signaling pathway|nodal binding|positive regulation of apoptotic process|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|negative regulation of insulin secretion|metal ion binding|activin receptor complex|cellular response to growth factor stimulus|negative regulation of trophoblast cell migration|negative regulation of chorionic trophoblast cell proliferation",null,null,"R-HSA-1181150,R-HSA-1266738,R-HSA-1433617,R-HSA-1502540,R-HSA-1502540,R-HSA-162582,R-HSA-162582,R-HSA-9006936,R-HSA-9006936","Signaling by NODAL|Developmental Biology|Regulation of signaling by NODAL|Signaling by Activin|Signaling by Activin|Signal Transduction|Signal Transduction|Signaling by TGFB family members|Signaling by TGFB family members"]
["ACVR2A",1.0924150881788,1.3427225677277,0.988133603937199,1.03333773607925,1.09183331897968,1.07735931863812,1.1122922624659,0.968499215908121,1.17910069029409,0.672598195451945,0.867855472421126,1.07396764146075,1.17644525823038,1.10330729838829,1.22933369450307,1.0499641483839,1.1174328211365,0.798464679253064,1.10183727885365,0.853822529129654,0.663844647051892,0.678029474989141,1.05875639152249,0.701759758161573,0.959410332442249,0.734651038866731,1.08607193539273,0.670595940010587,92,"activin A receptor type 2A","protein_coding","hsa04350,hsa04060,hsa04550,hsa05418","TGF-beta signaling pathway|Cytokine-cytokine receptor interaction|Signaling pathways regulating pluripotency of stem cells|Fluid shear stress and atherosclerosis","GO:0001702,GO:0001934,GO:0004674,GO:0004675,GO:0005515,GO:0005524,GO:0005737,GO:0005886,GO:0006468,GO:0007178,GO:0007283,GO:0007368,GO:0007498,GO:0009952,GO:0009986,GO:0015026,GO:0016310,GO:0017002,GO:0019838,GO:0030165,GO:0030501,GO:0030509,GO:0032924,GO:0032927,GO:0034673,GO:0034711,GO:0042475,GO:0042713,GO:0043084,GO:0043235,GO:0043621,GO:0045428,GO:0045648,GO:0045669,GO:0045944,GO:0046872,GO:0048179,GO:0048185,GO:0048706,GO:0060011,GO:0071363,GO:0071773,GO:0098821","gastrulation with mouth forming second|positive regulation of protein phosphorylation|protein serine/threonine kinase activity|transmembrane receptor protein serine/threonine kinase activity|protein binding|ATP binding|cytoplasm|plasma membrane|protein phosphorylation|transmembrane receptor protein serine/threonine kinase signaling pathway|spermatogenesis|determination of left/right symmetry|mesoderm development|anterior/posterior pattern specification|cell surface|coreceptor activity|phosphorylation|activin receptor activity|growth factor binding|PDZ domain binding|positive regulation of bone mineralization|BMP signaling pathway|activin receptor signaling pathway|positive regulation of activin receptor signaling pathway|inhibin-betaglycan-ActRII complex|inhibin binding|odontogenesis of dentin-containing tooth|sperm ejaculation|penile erection|receptor complex|protein self-association|regulation of nitric oxide biosynthetic process|positive regulation of erythrocyte differentiation|positive regulation of osteoblast differentiation|positive regulation of transcription by RNA polymerase II|metal ion binding|activin receptor complex|activin binding|embryonic skeletal system development|Sertoli cell proliferation|cellular response to growth factor stimulus|cellular response to BMP stimulus|BMP receptor activity","WP2857","Mesodermal commitment pathway","R-HSA-1181150,R-HSA-1266738,R-HSA-1433617,R-HSA-1502540,R-HSA-1502540,R-HSA-162582,R-HSA-162582,R-HSA-201451,R-HSA-9006936,R-HSA-9006936","Signaling by NODAL|Developmental Biology|Regulation of signaling by NODAL|Signaling by Activin|Signaling by Activin|Signal Transduction|Signal Transduction|Signaling by BMP|Signaling by TGFB family members|Signaling by TGFB family members"]
["ACVR2B",0.181683788669115,0.262050114143606,0.157988119195179,0.158534683207783,0.227010369370755,0.230743487642256,0.193129487218242,0.160634764278446,0.287605397380669,0.203670804315297,0.175064651234879,0.215750935266488,0.290326498173508,0.242782505234958,0.275606692788541,0.256983746090312,0.231949418866032,0.168105610827682,0.206454138029029,0.189031556720436,0.127909119480811,0.155710533750422,0.214646204259301,0.206598462216993,0.21998937292898,0.158482091337677,0.252189438103705,0.170803782852355,93,"activin A receptor type 2B","protein_coding","hsa04350,hsa04060,hsa04550,hsa05418","TGF-beta signaling pathway|Cytokine-cytokine receptor interaction|Signaling pathways regulating pluripotency of stem cells|Fluid shear stress and atherosclerosis","GO:0000122,GO:0001702,GO:0001822,GO:0001946,GO:0001974,GO:0004674,GO:0004712,GO:0005515,GO:0005524,GO:0005737,GO:0005886,GO:0006355,GO:0006468,GO:0007165,GO:0007178,GO:0007368,GO:0007498,GO:0007507,GO:0009749,GO:0009791,GO:0009952,GO:0016310,GO:0016362,GO:0017002,GO:0019209,GO:0019838,GO:0030073,GO:0030324,GO:0030501,GO:0030509,GO:0031016,GO:0032924,GO:0032927,GO:0032991,GO:0035265,GO:0042475,GO:0043235,GO:0045669,GO:0046872,GO:0048179,GO:0048185,GO:0048617,GO:0048705,GO:0060021,GO:0060836,GO:0060840,GO:0060841,GO:0061298,GO:0071363,GO:0120163","negative regulation of transcription by RNA polymerase II|gastrulation with mouth forming second|kidney development|lymphangiogenesis|blood vessel remodeling|protein serine/threonine kinase activity|protein serine/threonine/tyrosine kinase activity|protein binding|ATP binding|cytoplasm|plasma membrane|regulation of DNA-templated transcription|protein phosphorylation|signal transduction|transmembrane receptor protein serine/threonine kinase signaling pathway|determination of left/right symmetry|mesoderm development|heart development|response to glucose|post-embryonic development|anterior/posterior pattern specification|phosphorylation|activin receptor activity, type II|activin receptor activity|kinase activator activity|growth factor binding|insulin secretion|lung development|positive regulation of bone mineralization|BMP signaling pathway|pancreas development|activin receptor signaling pathway|positive regulation of activin receptor signaling pathway|protein-containing complex|organ growth|odontogenesis of dentin-containing tooth|receptor complex|positive regulation of osteoblast differentiation|metal ion binding|activin receptor complex|activin binding|embryonic foregut morphogenesis|skeletal system morphogenesis|roof of mouth development|lymphatic endothelial cell differentiation|artery development|venous blood vessel development|retina vasculature development in camera-type eye|cellular response to growth factor stimulus|negative regulation of cold-induced thermogenesis","WP3850,WP5316,WP2857","Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling|Primary ovarian insufficiency|Mesodermal commitment pathway","R-HSA-1181150,R-HSA-1266738,R-HSA-1433617,R-HSA-1502540,R-HSA-1502540,R-HSA-162582,R-HSA-162582,R-HSA-201451,R-HSA-9006936,R-HSA-9006936","Signaling by NODAL|Developmental Biology|Regulation of signaling by NODAL|Signaling by Activin|Signaling by Activin|Signal Transduction|Signal Transduction|Signaling by BMP|Signaling by TGFB family members|Signaling by TGFB family members"]
["ACVR2B-AS1",0.160644906050316,0.142613294732227,0.0402184500518869,0.143796626938323,0.0418601173148746,0.0201138337839057,0.0299760493233414,0.0630111576162999,0.0323173997938238,0.165036410612285,0.0805745316361394,0.12929769829356,0.0712935445876734,0.11231385037845,0.169318712523307,0.162470158106615,0.154450346197488,0.0594556294884987,0.0692866758502034,0.10298636568897,0.0404333254174414,0.0916193424450016,0.0528639626335114,0.083704359976717,0.063706836028629,0.0508805184620172,0.0621812500475418,0.0805465594198269,100128640,"ACVR2B antisense RNA 1","non_coding"]
["ACVRL1",6.94577325079884,7.06100378750464,7.42375152611645,7.55428697154598,7.66094362419736,7.24139834348105,8.00042434337579,7.48369530846788,4.63302713408718,6.09385274387906,5.62774244254757,5.15782796766444,4.50260146671553,5.37814006014661,5.56522140468713,5.81325729013725,6.12438964226678,6.68170632050245,5.72314419804675,6.56729381776047,6.13375889345136,5.91521066154192,5.21833976721641,6.2233364298981,6.30931456597506,6.54153518859534,5.48846667796363,6.07493049911918,94,"activin A receptor like type 1","protein_coding","hsa04060","Cytokine-cytokine receptor interaction","GO:0001525,GO:0001666,GO:0001701,GO:0001936,GO:0001937,GO:0001938,GO:0001946,GO:0001955,GO:0001974,GO:0002043,GO:0003203,GO:0004674,GO:0004675,GO:0005024,GO:0005025,GO:0005515,GO:0005524,GO:0005886,GO:0006275,GO:0006355,GO:0006468,GO:0007162,GO:0007165,GO:0007179,GO:0007507,GO:0008015,GO:0008217,GO:0008285,GO:0009953,GO:0009986,GO:0010596,GO:0010629,GO:0016361,GO:0019901,GO:0030308,GO:0030336,GO:0030425,GO:0030509,GO:0030513,GO:0032332,GO:0032924,GO:0035313,GO:0035912,GO:0043025,GO:0043535,GO:0043537,GO:0045602,GO:0045603,GO:0045766,GO:0045893,GO:0045944,GO:0046332,GO:0046872,GO:0048185,GO:0050431,GO:0051895,GO:0060836,GO:0060840,GO:0060841,GO:0061154,GO:0061298,GO:0070724,GO:0071363,GO:0071560,GO:0071773,GO:0090500,GO:0098821,GO:2000279","angiogenesis|response to hypoxia|in utero embryonic development|regulation of endothelial cell proliferation|negative regulation of endothelial cell proliferation|positive regulation of endothelial cell proliferation|lymphangiogenesis|blood vessel maturation|blood vessel remodeling|blood vessel endothelial cell proliferation involved in sprouting angiogenesis|endocardial cushion morphogenesis|protein serine/threonine kinase activity|transmembrane receptor protein serine/threonine kinase activity|transforming growth factor beta receptor activity|transforming growth factor beta receptor activity, type I|protein binding|ATP binding|plasma membrane|regulation of DNA replication|regulation of DNA-templated transcription|protein phosphorylation|negative regulation of cell adhesion|signal transduction|transforming growth factor beta receptor signaling pathway|heart development|blood circulation|regulation of blood pressure|negative regulation of cell population proliferation|dorsal/ventral pattern formation|cell surface|negative regulation of endothelial cell migration|negative regulation of gene expression|activin receptor activity, type I|protein kinase binding|negative regulation of cell growth|negative regulation of cell migration|dendrite|BMP signaling pathway|positive regulation of BMP signaling pathway|positive regulation of chondrocyte differentiation|activin receptor signaling pathway|wound healing, spreading of epidermal cells|dorsal aorta morphogenesis|neuronal cell body|regulation of blood vessel endothelial cell migration|negative regulation of blood vessel endothelial cell migration|negative regulation of endothelial cell differentiation|positive regulation of endothelial cell differentiation|positive regulation of angiogenesis|positive regulation of DNA-templated transcription|positive regulation of transcription by RNA polymerase II|SMAD binding|metal ion binding|activin binding|transforming growth factor beta binding|negative regulation of focal adhesion assembly|lymphatic endothelial cell differentiation|artery development|venous blood vessel development|endothelial tube morphogenesis|retina vasculature development in camera-type eye|BMP receptor complex|cellular response to growth factor stimulus|cellular response to transforming growth factor beta stimulus|cellular response to BMP stimulus|endocardial cushion to mesenchymal transition|BMP receptor activity|negative regulation of DNA biosynthetic process","WP5300,WP4331","TROP2 regulatory signaling|Neovascularisation processes","R-HSA-162582,R-HSA-201451,R-HSA-9006936","Signal Transduction|Signaling by BMP|Signaling by TGFB family members"]
["ACY1",0,0.0180308249367598,0,0.0363608710070081,0,0.0356023344824829,0.0176862907048406,0.0185887346132474,0.0190677204128116,0.0365151762931717,0.0356550801913085,0.0572155953946716,0.01802751172666,0.0180727503773532,0.10577691720555,0,0.0911278765539331,0.0526194864354962,0.017520048534756,0.018229021268575,0.0178921730090893,0,0.0187142888816523,0.0185200311235405,0.0375879292742754,0.0180121329070179,0,0.0356427021905246,95,"aminoacylase 1","protein_coding","hsa00220","Arginine biosynthesis","GO:0004046,GO:0005515,GO:0005829,GO:0006520,GO:0042802,GO:0046872,GO:0070062","aminoacylase activity|protein binding|cytosol|amino acid metabolic process|identical protein binding|metal ion binding|extracellular exosome","WP497,WP4519,WP1981","Urea cycle and metabolism of amino groups|Cerebral organic acidurias, including diseases|Thyroxine (thyroid hormone) production","R-HSA-1430728,R-HSA-1643685,R-HSA-211859,R-HSA-5423646,R-HSA-5579007,R-HSA-5579029,R-HSA-5668914,R-HSA-9748784,R-HSA-9753281","Metabolism|Disease|Biological oxidations|Aflatoxin activation and detoxification|Defective ACY1 causes encephalopathy|Metabolic disorders of biological oxidation enzymes|Diseases of metabolism|Drug ADME|Paracetamol ADME"]
["ACY3",0.105779785095787,0.0670760838720014,0.066206565585742,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.0167579307415209,0,0,0,0.0167516370135902,0,0,91703,"aminoacylase 3","protein_coding",null,null,"GO:0003674,GO:0004046,GO:0005515,GO:0005829,GO:0008150,GO:0016324,GO:0016788,GO:0042802,GO:0046872,GO:0070062","molecular_function|aminoacylase activity|protein binding|cytosol|biological_process|apical plasma membrane|hydrolase activity, acting on ester bonds|identical protein binding|metal ion binding|extracellular exosome",null,null,"R-HSA-1430728,R-HSA-211859,R-HSA-5423646","Metabolism|Biological oxidations|Aflatoxin activation and detoxification"]
["ACYP1",7.0129990855917,4.943335990676,7.1131303672779,7.92692326538844,5.3537558578018,4.14537704320952,5.54992104835523,6.53921889903374,4.81822027797187,3.76920591527948,4.74038639323957,5.89021596352253,4.31718076994196,3.73104689846056,4.71683967385588,3.62154190842267,6.50176760494626,8.77737036102071,9.83808718418567,7.0148068534633,8.48089000630834,9.31470408883258,11.0341273030503,7.55501116335148,8.97041825708345,8.29976490739195,10.0886369959538,8.94768434642133,97,"acylphosphatase 1","protein_coding","hsa00620","Pyruvate metabolism","GO:0003998,GO:0006796","acylphosphatase activity|phosphate-containing compound metabolic process"]
["ACYP2",2.03325865904831,1.73127990030134,1.86721705260657,2.16289694948604,1.90873034930325,1.80094338619295,2.02955428809599,1.93286103348102,1.16102068363384,1.31692777109504,1.36940875185353,1.24166887950373,1.19900766729054,1.2104813894049,1.13950588080525,1.14491692938471,1.74997940014736,1.13371075320114,1.59196994373718,1.69054358112481,1.54198000114697,1.89048888249273,1.62159683007124,1.55271794536355,1.50526285543336,1.77166769719818,1.42625682133091,2.26207888694745,98,"acylphosphatase 2","protein_coding","hsa00620","Pyruvate metabolism","GO:0003998,GO:0005515,GO:0006796,GO:0042802","acylphosphatase activity|protein binding|phosphate-containing compound metabolic process|identical protein binding"]
["ADA",5.29754497270152,5.587289824588,7.25728623610915,6.94701662631355,6.32101062601481,7.2251082499187,7.69963680821245,6.13122571868524,3.31678917924086,3.87004729064923,4.06696716834551,3.535051793001,3.27293331549754,3.69343714763918,4.07205777993641,4.62993115539893,1.45521959874521,1.95064938418432,1.58207443620334,1.23023960248521,2.0238487515054,1.25031414142803,1.33414365590122,2.09486806595138,1.37555238233874,2.0031755349413,1.6564694301602,1.91419894524954,100,"adenosine deaminase","protein_coding","hsa00230,hsa05340","Purine metabolism|Primary immunodeficiency","GO:0000255,GO:0001666,GO:0001829,GO:0001889,GO:0001890,GO:0002314,GO:0002467,GO:0002636,GO:0002686,GO:0002901,GO:0002906,GO:0004000,GO:0005515,GO:0005764,GO:0005829,GO:0005886,GO:0006154,GO:0006157,GO:0006196,GO:0006805,GO:0006939,GO:0007155,GO:0008270,GO:0009897,GO:0009986,GO:0010035,GO:0010460,GO:0014074,GO:0016020,GO:0019239,GO:0019722,GO:0030890,GO:0032261,GO:0032263,GO:0033077,GO:0033089,GO:0033632,GO:0042100,GO:0042110,GO:0043084,GO:0043101,GO:0043103,GO:0043605,GO:0044209,GO:0045987,GO:0046059,GO:0046061,GO:0046085,GO:0046103,GO:0046111,GO:0046632,GO:0046638,GO:0046936,GO:0048286,GO:0048541,GO:0048566,GO:0050728,GO:0050850,GO:0050852,GO:0050862,GO:0050900,GO:0060169,GO:0060205,GO:0060407,GO:0070161,GO:0070242,GO:0070244,GO:0070254,GO:0070256","allantoin metabolic process|response to hypoxia|trophectodermal cell differentiation|liver development|placenta development|germinal center B cell differentiation|germinal center formation|positive regulation of germinal center formation|negative regulation of leukocyte migration|mature B cell apoptotic process|negative regulation of mature B cell apoptotic process|adenosine deaminase activity|protein binding|lysosome|cytosol|plasma membrane|adenosine catabolic process|deoxyadenosine catabolic process|AMP catabolic process|xenobiotic metabolic process|smooth muscle contraction|cell adhesion|zinc ion binding|external side of plasma membrane|cell surface|response to inorganic substance|positive regulation of heart rate|response to purine-containing compound|membrane|deaminase activity|calcium-mediated signaling|positive regulation of B cell proliferation|purine nucleotide salvage|GMP salvage|T cell differentiation in thymus|positive regulation of T cell differentiation in thymus|regulation of cell-cell adhesion mediated by integrin|B cell proliferation|T cell activation|penile erection|purine-containing compound salvage|hypoxanthine salvage|amide catabolic process|AMP salvage|positive regulation of smooth muscle contraction|dAMP catabolic process|dATP catabolic process|adenosine metabolic process|inosine biosynthetic process|xanthine biosynthetic process|alpha-beta T cell differentiation|positive regulation of alpha-beta T cell differentiation|2'-deoxyadenosine deaminase activity|lung alveolus development|Peyer's patch development|embryonic digestive tract development|negative regulation of inflammatory response|positive regulation of calcium-mediated signaling|T cell receptor signaling pathway|positive regulation of T cell receptor signaling pathway|leukocyte migration|negative regulation of adenosine receptor signaling pathway|cytoplasmic vesicle lumen|negative regulation of penile erection|anchoring junction|thymocyte apoptotic process|negative regulation of thymocyte apoptotic process|mucus secretion|negative regulation of mucus secretion","WP4792,WP3591,WP3594,WP4224","Purine metabolism|Sleep regulation|Circadian rhythm genes|Purine metabolism and related disorders","R-HSA-1430728,R-HSA-15869,R-HSA-1643685,R-HSA-5668914,R-HSA-74217,R-HSA-8956321,R-HSA-9734207,R-HSA-9734735,R-HSA-9735804,R-HSA-9748784,R-HSA-9755088","Metabolism|Metabolism of nucleotides|Disease|Diseases of metabolism|Purine salvage|Nucleotide salvage|Nucleotide salvage defects|Defective ADA disrupts (deoxy)adenosine deamination|Diseases of nucleotide metabolism|Drug ADME|Ribavirin ADME"]
["ADA2",0.0214756335526156,0.069451427982988,0.0685511177210879,0.0865048064062521,0.117516476572781,0.052433457237347,0.0200365721656178,0.0842357572340275,0.0129609457108117,0.0496410905247515,0.0646290937310908,0.017285017346765,0.053100156433881,0.0327590198044567,0.0279611066991728,0.0407243256009351,0.0578130582038145,0.0198706473633088,0.0317571816652939,0.016521139734808,0.0324317017449649,0.00816535248686598,0.0212011781307438,0.0209811060051582,0.0340663068374886,0.0163245716977561,0.0789699894047055,0.0121137482110244,51816,"adenosine deaminase 2","protein_coding","hsa00230","Purine metabolism","GO:0004000,GO:0005576,GO:0005615,GO:0006154,GO:0007165,GO:0008083,GO:0008201,GO:0008270,GO:0031685,GO:0035578,GO:0042803,GO:0043394,GO:0046103,GO:0046936","adenosine deaminase activity|extracellular region|extracellular space|adenosine catabolic process|signal transduction|growth factor activity|heparin binding|zinc ion binding|adenosine receptor binding|azurophil granule lumen|protein homodimerization activity|proteoglycan binding|inosine biosynthetic process|2'-deoxyadenosine deaminase activity",null,null,"R-HSA-168249,R-HSA-168256,R-HSA-392499,R-HSA-5683826,R-HSA-6798695","Innate Immune System|Immune System|Metabolism of proteins|Surfactant metabolism|Neutrophil degranulation"]
["ADAD2",0,0.0113250146025055,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,161931,"adenosine deaminase domain containing 2","protein_coding",null,null,"GO:0003725,GO:0003726,GO:0005634,GO:0005730,GO:0005737,GO:0006382,GO:0006396,GO:0007286,GO:0008251","double-stranded RNA binding|double-stranded RNA adenosine deaminase activity|nucleus|nucleolus|cytoplasm|adenosine to inosine editing|RNA processing|spermatid development|tRNA-specific adenosine deaminase activity"]
["ADAL",1.86540696860262,2.20241575470749,2.1942295571534,2.18428551601544,2.06654329912494,1.83827937918997,1.97313681333545,2.05786378997277,1.17817108433633,1.16989600425582,1.22903513294325,1.75127372795833,1.50066795564582,1.37001700356025,1.44736273011554,1.42420610117877,1.94466998557495,1.97686678912643,2.23524945108121,1.83553152722946,2.16500692375885,2.02055269215125,2.20559809723604,2.33104266211563,1.94080293598019,1.98372609185377,2.0727396069207,1.96271476244684,161823,"adenosine deaminase like","protein_coding",null,null,"GO:0004000,GO:0005829,GO:0006154,GO:0009117,GO:0046103,GO:0046872,GO:0062154","adenosine deaminase activity|cytosol|adenosine catabolic process|nucleotide metabolic process|inosine biosynthetic process|metal ion binding|N6-methyl-AMP deaminase activity",null,null,"R-HSA-1430728,R-HSA-15869,R-HSA-2161522,R-HSA-2161541,R-HSA-74217,R-HSA-8956321,R-HSA-9748784","Metabolism|Metabolism of nucleotides|Abacavir ADME|Abacavir metabolism|Purine salvage|Nucleotide salvage|Drug ADME"]
["ADAM10",21.8742668025441,20.6566986912923,19.6451110343197,15.4727572937554,25.3710190085489,20.8046845027649,20.0289140568705,19.1774708470177,20.9495647334613,12.4999376724578,12.3173826035474,16.2003054655921,24.0354719820674,15.9277621517192,20.9492071445905,21.6762983277435,17.3045322696836,15.1212799295896,15.392282710941,19.8198951453684,17.4707831197914,16.3326046973997,21.5430436663033,18.9345855924993,18.3513360825239,13.7267142257924,17.7369024694304,13.2726564961858,102,"ADAM metallopeptidase domain 10","protein_coding","hsa05120,hsa05010","Epithelial cell signaling in Helicobacter pylori infection|Alzheimer disease","GO:0000139,GO:0001701,GO:0004175,GO:0004222,GO:0005102,GO:0005178,GO:0005515,GO:0005634,GO:0005737,GO:0005788,GO:0005794,GO:0005798,GO:0005886,GO:0005912,GO:0005925,GO:0006468,GO:0006509,GO:0007162,GO:0007219,GO:0007229,GO:0007267,GO:0008237,GO:0008284,GO:0008593,GO:0009986,GO:0010629,GO:0010820,GO:0014069,GO:0016020,GO:0016485,GO:0017124,GO:0019901,GO:0022617,GO:0030136,GO:0030307,GO:0030335,GO:0030424,GO:0030425,GO:0034332,GO:0034612,GO:0035579,GO:0038004,GO:0042117,GO:0042803,GO:0042987,GO:0043231,GO:0046872,GO:0046930,GO:0046931,GO:0051089,GO:0060090,GO:0070062,GO:0070573,GO:0070821,GO:0090102,GO:0097038,GO:0097060,GO:0097197,GO:0098696,GO:0098978,GO:0099173,GO:0099175,GO:0140249,GO:1901342,GO:1901998,GO:1902945","Golgi membrane|in utero embryonic development|endopeptidase activity|metalloendopeptidase activity|signaling receptor binding|integrin binding|protein binding|nucleus|cytoplasm|endoplasmic reticulum lumen|Golgi apparatus|Golgi-associated vesicle|plasma membrane|adherens junction|focal adhesion|protein phosphorylation|membrane protein ectodomain proteolysis|negative regulation of cell adhesion|Notch signaling pathway|integrin-mediated signaling pathway|cell-cell signaling|metallopeptidase activity|positive regulation of cell population proliferation|regulation of Notch signaling pathway|cell surface|negative regulation of gene expression|positive regulation of T cell chemotaxis|postsynaptic density|membrane|protein processing|SH3 domain binding|protein kinase binding|extracellular matrix disassembly|clathrin-coated vesicle|positive regulation of cell growth|positive regulation of cell migration|axon|dendrite|adherens junction organization|response to tumor necrosis factor|specific granule membrane|epidermal growth factor receptor ligand maturation|monocyte activation|protein homodimerization activity|amyloid precursor protein catabolic process|intracellular membrane-bounded organelle|metal ion binding|pore complex|pore complex assembly|constitutive protein ectodomain proteolysis|molecular adaptor activity|extracellular exosome|metallodipeptidase activity|tertiary granule membrane|cochlea development|perinuclear endoplasmic reticulum|synaptic membrane|tetraspanin-enriched microdomain|regulation of neurotransmitter receptor localization to postsynaptic specialization membrane|glutamatergic synapse|postsynapse organization|regulation of postsynapse organization|protein catabolic process at postsynapse|regulation of vasculature development|toxin transport|metalloendopeptidase activity involved in amyloid precursor protein catabolic process","WP5092,WP5124,WP5402,WP3286,WP2059,WP5380,WP5300,WP3845,WP516,WP3888,WP4906","Interactions of natural killer cells in pancreatic cancer|Alzheimer's disease|10q22q23 copy number variation|Copper homeostasis|Alzheimer's disease and miRNA effects|5q35 copy number variation|TROP2 regulatory signaling|Canonical and non-canonical Notch signaling|Hypertrophy model|VEGFA-VEGFR2 signaling|3q29 copy number variation syndrome","R-HSA-1266738,R-HSA-1442490,R-HSA-1474228,R-HSA-1474228,R-HSA-1474244,R-HSA-1474244,R-HSA-157118,R-HSA-157118,R-HSA-162582,R-HSA-162582,R-HSA-1643685,R-HSA-168249,R-HSA-168256,R-HSA-177929,R-HSA-1980143,R-HSA-1980145,R-HSA-2122948,R-HSA-2644602,R-HSA-2644603,R-HSA-2644606,R-HSA-2660825,R-HSA-2660826,R-HSA-2682334,R-HSA-2691230,R-HSA-2691232,R-HSA-2894858,R-HSA-2894862,R-HSA-2979096,R-HSA-381426,R-HSA-392499,R-HSA-3928665,R-HSA-422475,R-HSA-5663202,R-HSA-597592,R-HSA-6798695,R-HSA-8957275,R-HSA-9006934,R-HSA-9012852,R-HSA-9013507,R-HSA-9013694,R-HSA-9013700,R-HSA-9675108,R-HSA-977225","Developmental Biology|Collagen degradation|Degradation of the extracellular matrix|Degradation of the extracellular matrix|Extracellular matrix organization|Extracellular matrix organization|Signaling by NOTCH|Signaling by NOTCH|Signal Transduction|Signal Transduction|Disease|Innate Immune System|Immune System|Signaling by EGFR|Signaling by NOTCH1|Signaling by NOTCH2|Activated NOTCH1 Transmits Signal to the Nucleus|Signaling by NOTCH1 PEST Domain Mutants in Cancer|Signaling by NOTCH1 in Cancer|Constitutive Signaling by NOTCH1 PEST Domain Mutants|Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant|Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant|EPH-Ephrin signaling|Signaling by NOTCH1 HD Domain Mutants in Cancer|Constitutive Signaling by NOTCH1 HD Domain Mutants|Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer|Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants|NOTCH2 Activation and Transmission of Signal to the Nucleus|Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)|Metabolism of proteins|EPH-ephrin mediated repulsion of cells|Axon guidance|Diseases of signal transduction by growth factor receptors and second messengers|Post-translational protein modification|Neutrophil degranulation|Post-translational protein phosphorylation|Signaling by Receptor Tyrosine Kinases|Signaling by NOTCH3|NOTCH3 Activation and Transmission of Signal to the Nucleus|Signaling by NOTCH4|NOTCH4 Activation and Transmission of Signal to the Nucleus|Nervous system development|Amyloid fiber formation"]
["ADAM11",0.532481466606601,0.471375769146649,0.485063768848951,0.556186919901839,0.448195121723739,0.881236113325655,0.265616055279348,0.491130874027693,0.689391510954892,0.680412068483403,0.75363110237338,0.641803883877566,0.636741727511136,0.81425993896511,0.573653068099494,0.629841957782223,0.12165117039048,0.102439735571861,0.0292354887734282,0.0557673285122338,0.0895693448739781,0.0751697910339882,0.0572518886537857,0.159671428122024,0.0993106466978657,0.140264244831962,0.0816273323526502,0.153647721295003,4185,"ADAM metallopeptidase domain 11","protein_coding",null,null,"GO:0004222,GO:0005178,GO:0005886,GO:0006508,GO:0007229,GO:0008237,GO:0030424,GO:0033555,GO:0042734,GO:0043204,GO:0045184,GO:0061367,GO:0061368,GO:0062023","metalloendopeptidase activity|integrin binding|plasma membrane|proteolysis|integrin-mediated signaling pathway|metallopeptidase activity|axon|multicellular organismal response to stress|presynaptic membrane|perikaryon|establishment of protein localization|behavioral response to acetic acid induced pain|behavioral response to formalin induced pain|collagen-containing extracellular matrix",null,null,"R-HSA-1266738,R-HSA-5682910","Developmental Biology|LGI-ADAM interactions"]
["ADAM12",3.676406052687,3.68153314519229,3.18621586644197,2.66327054363757,3.7845377537539,3.34156260507627,2.90499864339075,2.70380423517936,2.36066687918701,2.07575245073191,1.58543374446075,2.05212503784955,2.26460323670124,1.78061653640379,2.33344708675791,2.00619410969947,3.25111431256336,3.26749309432956,2.38482855932576,3.63456338400395,3.41199449337575,3.08109887691612,2.86035340077196,3.07795522092614,3.45483408865584,2.69699217866854,2.46843519937566,2.73080483237499,8038,"ADAM metallopeptidase domain 12","protein_coding",null,null,"GO:0004222,GO:0005515,GO:0005576,GO:0005654,GO:0005886,GO:0006508,GO:0007155,GO:0007520,GO:0008237,GO:0017124,GO:0045766,GO:0046872","metalloendopeptidase activity|protein binding|extracellular region|nucleoplasm|plasma membrane|proteolysis|cell adhesion|myoblast fusion|metallopeptidase activity|SH3 domain binding|positive regulation of angiogenesis|metal ion binding","WP5055","Burn wound healing","R-HSA-1474244,R-HSA-162582,R-HSA-177929,R-HSA-8941237,R-HSA-9006934","Extracellular matrix organization|Signal Transduction|Signaling by EGFR|Invadopodia formation|Signaling by Receptor Tyrosine Kinases"]
["ADAM15",20.7105675903767,21.0298908787434,21.0856406542536,21.8912325680811,19.6190591399282,20.6681945308776,21.3195367219604,21.7214273862529,17.3139495979754,21.4467606985005,18.717430095239,16.8736691767648,16.7891436365951,18.625552095105,16.2790577546981,17.8523214814022,25.5644857947358,26.3054517304391,28.8925896965253,25.2570100838134,25.6391688605911,24.7204949249681,21.2762212628262,23.3008424201359,23.2739650712986,27.1799579961793,22.3217625189973,29.021516954407,8751,"ADAM metallopeptidase domain 15","protein_coding",null,null,"GO:0001525,GO:0001669,GO:0001953,GO:0002418,GO:0004222,GO:0005178,GO:0005515,GO:0005615,GO:0005886,GO:0005912,GO:0006508,GO:0006915,GO:0007160,GO:0007229,GO:0008237,GO:0008584,GO:0009986,GO:0017124,GO:0022617,GO:0030308,GO:0030336,GO:0030574,GO:0031514,GO:0042246,GO:0045087,GO:0046872,GO:0060317,GO:0070062,GO:1900121,GO:1904628,GO:1990910","angiogenesis|acrosomal vesicle|negative regulation of cell-matrix adhesion|immune response to tumor cell|metalloendopeptidase activity|integrin binding|protein binding|extracellular space|plasma membrane|adherens junction|proteolysis|apoptotic process|cell-matrix adhesion|integrin-mediated signaling pathway|metallopeptidase activity|male gonad development|cell surface|SH3 domain binding|extracellular matrix disassembly|negative regulation of cell growth|negative regulation of cell migration|collagen catabolic process|motile cilium|tissue regeneration|innate immune response|metal ion binding|cardiac epithelial to mesenchymal transition|extracellular exosome|negative regulation of receptor binding|cellular response to phorbol 13-acetate 12-myristate|response to hypobaric hypoxia",null,null,"R-HSA-1474228,R-HSA-1474244,R-HSA-8941237","Degradation of the extracellular matrix|Extracellular matrix organization|Invadopodia formation"]
["ADAM17",5.6020782935694,5.19404469541775,4.69443139085938,4.18738960265918,6.20031348918558,4.97996855555597,4.99305133825675,4.59431967624271,5.09865815491576,3.87061415833426,3.82882351096022,4.53493175221081,5.82302134548558,4.19724327687893,5.1535579122304,5.64479425611245,4.562811283792,4.16690512077076,4.009156230692,5.27055795729562,4.75763442967012,4.39205427970191,4.569527979174,4.74701641623951,4.58898266410777,4.17165208334406,4.0726110038255,3.78952312480493,6868,"ADAM metallopeptidase domain 17","protein_coding","hsa04330,hsa05171,hsa05120,hsa05010","Notch signaling pathway|Coronavirus disease - COVID-19|Epithelial cell signaling in Helicobacter pylori infection|Alzheimer disease","GO:0000139,GO:0001666,GO:0001934,GO:0002446,GO:0002467,GO:0002690,GO:0004175,GO:0004222,GO:0005112,GO:0005138,GO:0005178,GO:0005515,GO:0005737,GO:0005788,GO:0005829,GO:0005886,GO:0005911,GO:0005925,GO:0006508,GO:0006509,GO:0007155,GO:0007219,GO:0007220,GO:0008233,GO:0008237,GO:0008284,GO:0009410,GO:0009986,GO:0010820,GO:0015629,GO:0016020,GO:0016324,GO:0016485,GO:0017124,GO:0030165,GO:0030183,GO:0030307,GO:0030335,GO:0030511,GO:0030512,GO:0032496,GO:0032587,GO:0032722,GO:0033025,GO:0033077,GO:0033627,GO:0035313,GO:0035624,GO:0042987,GO:0043120,GO:0043536,GO:0045121,GO:0045737,GO:0045741,GO:0046872,GO:0048536,GO:0048870,GO:0050830,GO:0071403,GO:0071679,GO:0120163,GO:1900087,GO:1902945,GO:1903265,GO:1905564","Golgi membrane|response to hypoxia|positive regulation of protein phosphorylation|neutrophil mediated immunity|germinal center formation|positive regulation of leukocyte chemotaxis|endopeptidase activity|metalloendopeptidase activity|Notch binding|interleukin-6 receptor binding|integrin binding|protein binding|cytoplasm|endoplasmic reticulum lumen|cytosol|plasma membrane|cell-cell junction|focal adhesion|proteolysis|membrane protein ectodomain proteolysis|cell adhesion|Notch signaling pathway|Notch receptor processing|peptidase activity|metallopeptidase activity|positive regulation of cell population proliferation|response to xenobiotic stimulus|cell surface|positive regulation of T cell chemotaxis|actin cytoskeleton|membrane|apical plasma membrane|protein processing|SH3 domain binding|PDZ domain binding|B cell differentiation|positive regulation of cell growth|positive regulation of cell migration|positive regulation of transforming growth factor beta receptor signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|response to lipopolysaccharide|ruffle membrane|positive regulation of chemokine production|regulation of mast cell apoptotic process|T cell differentiation in thymus|cell adhesion mediated by integrin|wound healing, spreading of epidermal cells|receptor transactivation|amyloid precursor protein catabolic process|tumor necrosis factor binding|positive regulation of blood vessel endothelial cell migration|membrane raft|positive regulation of cyclin-dependent protein serine/threonine kinase activity|positive regulation of epidermal growth factor-activated receptor activity|metal ion binding|spleen development|cell motility|defense response to Gram-positive bacterium|cellular response to high density lipoprotein particle stimulus|commissural neuron axon guidance|negative regulation of cold-induced thermogenesis|positive regulation of G1/S transition of mitotic cell cycle|metalloendopeptidase activity involved in amyloid precursor protein catabolic process|positive regulation of tumor necrosis factor-mediated signaling pathway|positive regulation of vascular endothelial cell proliferation","WP5092,WP2840,WP5124,WP3286,WP61,WP2059,WP268,WP5076,WP2380,WP5300,WP4217","Interactions of natural killer cells in pancreatic cancer|Hair follicle development: cytodifferentiation - part 3 of 3|Alzheimer's disease|Copper homeostasis|Notch signaling pathway|Alzheimer's disease and miRNA effects|Notch signaling|Soluble ACE2-mediated cell entry of SARS-CoV-2|Brain-derived neurotrophic factor (BDNF) signaling pathway|TROP2 regulatory signaling|Ebola virus infection in host","R-HSA-1236394,R-HSA-1251985,R-HSA-1280215,R-HSA-1442490,R-HSA-1474228,R-HSA-1474244,R-HSA-157118,R-HSA-162582,R-HSA-162582,R-HSA-1643685,R-HSA-168256,R-HSA-177929,R-HSA-193692,R-HSA-193704,R-HSA-1980143,R-HSA-2122948,R-HSA-2644602,R-HSA-2644603,R-HSA-2644606,R-HSA-2660825,R-HSA-2660826,R-HSA-2691230,R-HSA-2691232,R-HSA-2894858,R-HSA-2894862,R-HSA-5358346,R-HSA-5358351,R-HSA-5362798,R-HSA-5663202,R-HSA-5663205,R-HSA-73887,R-HSA-75893,R-HSA-9006934,R-HSA-9658195,R-HSA-9662834,R-HSA-9662851,R-HSA-9664433,R-HSA-9824443,R-HSA-982772","Signaling by ERBB4|Nuclear signaling by ERBB4|Cytokine Signaling in Immune system|Collagen degradation|Degradation of the extracellular matrix|Extracellular matrix organization|Signaling by NOTCH|Signal Transduction|Signal Transduction|Disease|Immune System|Signaling by EGFR|Regulated proteolysis of p75NTR|p75 NTR receptor-mediated signalling|Signaling by NOTCH1|Activated NOTCH1 Transmits Signal to the Nucleus|Signaling by NOTCH1 PEST Domain Mutants in Cancer|Signaling by NOTCH1 in Cancer|Constitutive Signaling by NOTCH1 PEST Domain Mutants|Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant|Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant|Signaling by NOTCH1 HD Domain Mutants in Cancer|Constitutive Signaling by NOTCH1 HD Domain Mutants|Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer|Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants|Hedgehog ligand biogenesis|Signaling by Hedgehog|Release of Hh-Np from the secreting cell|Diseases of signal transduction by growth factor receptors and second messengers|Infectious disease|Death Receptor Signaling|TNF signaling|Signaling by Receptor Tyrosine Kinases|Leishmania infection|CD163 mediating an anti-inflammatory response|Anti-inflammatory response favouring Leishmania parasite infection|Leishmania parasite growth and survival|Parasitic Infection Pathways|Growth hormone receptor signaling"]
["ADAM19",9.71769275157431,10.4992568592933,9.07653153139869,8.52326601016841,10.4290603248172,10.591713705607,8.68293605942031,9.03639312831057,18.3755659806583,20.3906572447975,15.1573420712024,18.3837383693001,15.287868742124,13.2911811939383,11.8374490128944,13.4624569540125,19.7480103193234,16.8608690912071,8.14074143026243,17.2039049136928,20.2177310056409,15.7739967509977,8.58905420804833,15.5148500695343,21.125568616636,14.7894734587406,8.1176659186237,13.9925418497531,8728,"ADAM metallopeptidase domain 19","protein_coding",null,null,"GO:0001890,GO:0004222,GO:0005515,GO:0005634,GO:0005886,GO:0006509,GO:0010628,GO:0016485,GO:0017124,GO:0042987,GO:0046872,GO:0062023,GO:1902945,GO:2000049","placenta development|metalloendopeptidase activity|protein binding|nucleus|plasma membrane|membrane protein ectodomain proteolysis|positive regulation of gene expression|protein processing|SH3 domain binding|amyloid precursor protein catabolic process|metal ion binding|collagen-containing extracellular matrix|metalloendopeptidase activity involved in amyloid precursor protein catabolic process|positive regulation of cell-cell adhesion mediated by cadherin","WP2857","Mesodermal commitment pathway","R-HSA-1474244,R-HSA-1500931,R-HSA-418990,R-HSA-421270,R-HSA-446728,R-HSA-8941237,R-HSA-9759475,R-HSA-9759476,R-HSA-9762292,R-HSA-9764260","Extracellular matrix organization|Cell-Cell communication|Adherens junctions interactions|Cell-cell junction organization|Cell junction organization|Invadopodia formation|Regulation of CDH11 Expression and Function|Regulation of Homotypic Cell-Cell Adhesion|Regulation of CDH11 function|Regulation of Expression and Function of Type II Classical Cadherins"]
["ADAM20",0.0120340246585906,0.0095386283705627,0.00376599102606397,0.00769422002559011,0.0176387134957934,0.0226011248366476,1.87127272189609E-3,0.0118005270625168,0.00806973167470779,3.86343606316147E-3,5.65865223571883E-3,0.00403574288944558,0,3.82432307092207E-3,0.00559578780752578,0.00380336112308733,0.00192833095922162,0.0148462122443007,0.0074147348263164,0.00578608666158789,0.0094652790248977,0.00762585598326948,0.00396007720084965,0.00391897087167776,0.00596540573973434,0.00571724397182577,0.00970425386716659,3.77112518712247E-3,8748,"ADAM metallopeptidase domain 20","protein_coding",null,null,"GO:0004222,GO:0005886,GO:0006508,GO:0007338,GO:0008237,GO:0008584,GO:0009897,GO:0046872,GO:1990913","metalloendopeptidase activity|plasma membrane|proteolysis|single fertilization|metallopeptidase activity|male gonad development|external side of plasma membrane|metal ion binding|sperm head plasma membrane",null,null,"R-HSA-1187000,R-HSA-1474165,R-HSA-2534343","Fertilization|Reproduction|Interaction With Cumulus Cells And The Zona Pellucida"]
["ADAM21",0.0407347415719578,0.0484318720439602,0.0764864667779369,0.0781339759304353,0.0298532060676821,0.0382519982123844,0.0475064325317028,0.0798887211788072,0.0307302211110897,0.0882737488099757,0.0287315020959807,0.0922107026647787,0.0484229725638658,0.019417794511973,0.0473538522435125,0.0869011260764345,0.0391639865386302,0.0376904217157917,0.0376479169118596,0.0979284784431952,0.0384475557520589,0.0483998415258508,0.0904818545928927,0.0298475454374853,0.0605780529973778,0.048381664136342,0.10840021849051,0.0957384256043182,8747,"ADAM metallopeptidase domain 21","protein_coding",null,null,"GO:0004222,GO:0005515,GO:0005886,GO:0006508,GO:0007338,GO:0008237,GO:0008584,GO:0009897,GO:0030424,GO:0043025,GO:0046872,GO:1990913","metalloendopeptidase activity|protein binding|plasma membrane|proteolysis|single fertilization|metallopeptidase activity|male gonad development|external side of plasma membrane|axon|neuronal cell body|metal ion binding|sperm head plasma membrane",null,null,"R-HSA-1187000,R-HSA-1474165,R-HSA-2534343","Fertilization|Reproduction|Interaction With Cumulus Cells And The Zona Pellucida"]
["ADAM22",0.0685841663681691,0.0727620274725612,0.0866778637176089,0.0581866448358551,0.0799055527382259,0.0743123392221705,0.0492218522013572,0.0310400398708732,0.459024721388995,0.287086682544504,0.312574225855618,0.419316016273387,0.449034815527996,0.440102155925664,0.417041980057895,0.475206133864166,0.0836924696187468,0.102509906640361,0.0682628684274241,0.065951988877753,0.0896306997437421,0.0777286583048585,0.130207059348809,0.157203693093076,0.115070043978513,0.0827123347484805,0.0816832469554948,0.0867960313153152,53616,"ADAM metallopeptidase domain 22","protein_coding",null,null,"GO:0004222,GO:0005178,GO:0005515,GO:0005886,GO:0006508,GO:0007155,GO:0007162,GO:0007417,GO:0016020,GO:0030424","metalloendopeptidase activity|integrin binding|protein binding|plasma membrane|proteolysis|cell adhesion|negative regulation of cell adhesion|central nervous system development|membrane|axon",null,null,"R-HSA-1266738,R-HSA-5682910","Developmental Biology|LGI-ADAM interactions"]
["ADAM23",0.658696621312555,0.682398669770024,0.61840796453518,0.535158450589215,0.590354700410181,0.626429309091084,0.567585413296669,0.678828763004862,2.28308722941896,2.48106556754696,2.23718008763946,2.45242516390975,2.11464816932523,2.53194591535649,2.20062085121113,2.3350802211012,0.839017550680658,1.26552117073285,1.05858178388848,0.976349216346635,1.08106597901424,1.16848291025823,1.2135772148459,1.02062810586163,0.998288599433831,1.01257062418988,1.11242014384663,0.98212425729312,8745,"ADAM metallopeptidase domain 23","protein_coding",null,null,"GO:0004222,GO:0005178,GO:0005515,GO:0005576,GO:0005886,GO:0006508,GO:0007155,GO:0007417,GO:0008237,GO:0042734,GO:0098978,GO:1990830","metalloendopeptidase activity|integrin binding|protein binding|extracellular region|plasma membrane|proteolysis|cell adhesion|central nervous system development|metallopeptidase activity|presynaptic membrane|glutamatergic synapse|cellular response to leukemia inhibitory factor",null,null,"R-HSA-1266738,R-HSA-5682910","Developmental Biology|LGI-ADAM interactions"]
["ADAM28",0.180479965571991,0.229968184343753,0.159850048605039,0.186154247006192,0.179684923736834,0.214248156612182,0.111198419451733,0.210370184318138,0.143860603074123,0.0655944677727263,0.0448345967943765,0.099353912872051,0.0485759000921751,0.0941490752982938,0.041169616208982,0.0871755737964839,0.180068499880826,0.192198058463357,0.100711506888016,0.111336119289169,0.102850611496412,0.152131780808225,0.144555824653551,0.143055308625569,0.222821016817161,0.122953968388532,0.108742563799033,0.118450298954791,10863,"ADAM metallopeptidase domain 28","protein_coding",null,null,"GO:0004222,GO:0005515,GO:0005576,GO:0005739,GO:0005886,GO:0006508,GO:0007283,GO:0008237,GO:0046872","metalloendopeptidase activity|protein binding|extracellular region|mitochondrion|plasma membrane|proteolysis|spermatogenesis|metallopeptidase activity|metal ion binding"]
["ADAM30",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.00892112597710683,0,0,0,0,0,11085,"ADAM metallopeptidase domain 30","protein_coding",null,null,"GO:0004222,GO:0005886,GO:0006508,GO:0008237,GO:0008270,GO:0008584,GO:0009897,GO:0016020,GO:0031902,GO:1990913","metalloendopeptidase activity|plasma membrane|proteolysis|metallopeptidase activity|zinc ion binding|male gonad development|external side of plasma membrane|membrane|late endosome membrane|sperm head plasma membrane",null,null,"R-HSA-1187000,R-HSA-1474165,R-HSA-2534343","Fertilization|Reproduction|Interaction With Cumulus Cells And The Zona Pellucida"]
["ADAM32",0.0918440042086648,0.200925437949461,0.241434027756114,0.33471823266349,0.341035160195783,0.526101822432629,0.265637842197883,0.252173443734602,0.388006996229902,0.23883537965929,0.336858507197544,0.517455115555762,0.541525568609627,0.288954645385921,0.264784671451169,0.252537995116613,0.317888807942006,0.186956049250205,0.135814699919172,0.238461684015561,0.216717802546209,0.165872111063687,0.281077779380238,0.314051771386238,0.300485718760587,0.0959951560243864,0.346615448518844,0.172687981311502,203102,"ADAM metallopeptidase domain 32","protein_coding",null,null,"GO:0004222,GO:0005515,GO:0005886,GO:0006508,GO:0007155,GO:0007339,GO:0008584","metalloendopeptidase activity|protein binding|plasma membrane|proteolysis|cell adhesion|binding of sperm to zona pellucida|male gonad development"]
["ADAM33",1.51258609844367,2.41215239390367,2.68302581295285,2.70995279525941,1.94345939720604,2.82265815056356,2.00574699085068,2.40473777847049,14.1204118599156,26.179262684955,19.007018321467,19.8026618433174,13.497001741657,25.404901454515,15.1504217896365,20.4383254575441,6.90618748581744,9.98737452927484,3.84886349895553,8.8448099141721,7.86122612332592,8.91416678204761,4.14934392781289,6.30718498339245,7.53635289404146,7.93839598517806,4.13573611228335,7.642525565467,80332,"ADAM metallopeptidase domain 33","protein_coding",null,null,"GO:0004222,GO:0006508,GO:0008270,GO:0016020","metalloendopeptidase activity|proteolysis|zinc ion binding|membrane"]
["ADAM7",0,0,0,0,0,0,0,0,0,0,0.0287749852622251,0,0,0,0.00711382785973766,0.0290108816653199,0,0,0,0,0,0,0,0,0,0,0,0,8756,"ADAM metallopeptidase domain 7","protein_coding",null,null,"GO:0004222,GO:0005886,GO:0006508","metalloendopeptidase activity|plasma membrane|proteolysis"]
["ADAM8",0.583067699628049,0.838654523726983,0.667566860858609,0.736501863066774,0.819883012610238,0.50078989350525,0.417948836476881,0.515973454466578,0.264634408282688,0.369813684674237,0.407912551563503,0.314768783316083,0.41925020940893,0.311837179552474,0.145481626565481,0.262934551078535,0.211928201226614,0.585546202787613,0.374589821666082,0.574365637691573,0.22818538133565,0.283872539266417,0.252709542714204,0.173671091121568,0.204438278476994,0.378354568095924,0.309635069314816,0.407770940834936,101,"ADAM metallopeptidase domain 8","protein_coding",null,null,"GO:0000902,GO:0001525,GO:0002102,GO:0002523,GO:0002675,GO:0002693,GO:0004222,GO:0004252,GO:0005509,GO:0005515,GO:0005737,GO:0005886,GO:0006508,GO:0006954,GO:0008237,GO:0008270,GO:0009986,GO:0010718,GO:0010954,GO:0022407,GO:0022617,GO:0032010,GO:0032127,GO:0033089,GO:0035579,GO:0042581,GO:0043406,GO:0043524,GO:0043621,GO:0045089,GO:0045780,GO:0045785,GO:0048247,GO:0050714,GO:0050839,GO:0051044,GO:0051092,GO:0051897,GO:0070245,GO:0070820,GO:0070821,GO:0071133,GO:0071456,GO:0098609,GO:0101003,GO:1901394,GO:2000309,GO:2000391,GO:2000415,GO:2000418","cell morphogenesis|angiogenesis|podosome|leukocyte migration involved in inflammatory response|positive regulation of acute inflammatory response|positive regulation of cellular extravasation|metalloendopeptidase activity|serine-type endopeptidase activity|calcium ion binding|protein binding|cytoplasm|plasma membrane|proteolysis|inflammatory response|metallopeptidase activity|zinc ion binding|cell surface|positive regulation of epithelial to mesenchymal transition|positive regulation of protein processing|regulation of cell-cell adhesion|extracellular matrix disassembly|phagolysosome|dense core granule membrane|positive regulation of T cell differentiation in thymus|specific granule membrane|specific granule|positive regulation of MAP kinase activity|negative regulation of neuron apoptotic process|protein self-association|positive regulation of innate immune response|positive regulation of bone resorption|positive regulation of cell adhesion|lymphocyte chemotaxis|positive regulation of protein secretion|cell adhesion molecule binding|positive regulation of membrane protein ectodomain proteolysis|positive regulation of NF-kappaB transcription factor activity|positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction|positive regulation of thymocyte apoptotic process|tertiary granule|tertiary granule membrane|alpha9-beta1 integrin-ADAM8 complex|cellular response to hypoxia|cell-cell adhesion|ficolin-1-rich granule membrane|positive regulation of transforming growth factor beta1 activation|positive regulation of tumor necrosis factor (ligand) superfamily member 11 production|positive regulation of neutrophil extravasation|positive regulation of fibronectin-dependent thymocyte migration|positive regulation of eosinophil migration",null,null,"R-HSA-1474228,R-HSA-1474244,R-HSA-168249,R-HSA-168256,R-HSA-6798695","Degradation of the extracellular matrix|Extracellular matrix organization|Innate Immune System|Immune System|Neutrophil degranulation"]
["ADAM9",107.019938509673,79.6074129360318,60.3084103970564,50.0668103680203,106.821817222604,80.1214973457243,68.1721817644796,67.2612297409985,78.418861379795,50.1342702268994,35.7579169489129,58.9186904170296,90.1827610214578,62.8104520823537,67.2046542437189,77.58170370294,96.473846938155,69.0810999575708,66.0917127484015,83.9349743158995,88.6257560379955,71.523878000556,101.599026064601,107.457827710047,97.6223847924863,59.7000633689596,91.0762758369541,57.8047142066042,8754,"ADAM metallopeptidase domain 9","protein_coding",null,null,"GO:0004222,GO:0005080,GO:0005178,GO:0005515,GO:0005518,GO:0005615,GO:0005886,GO:0005925,GO:0006509,GO:0007155,GO:0007160,GO:0007179,GO:0007229,GO:0008237,GO:0009897,GO:0009986,GO:0010042,GO:0016323,GO:0016477,GO:0017124,GO:0030216,GO:0030335,GO:0031293,GO:0033627,GO:0033630,GO:0033631,GO:0034241,GO:0034612,GO:0034616,GO:0042117,GO:0042542,GO:0043236,GO:0043406,GO:0046872,GO:0050714,GO:0051044,GO:0051384,GO:0051549,GO:0051592,GO:0070062,GO:0071222,GO:0097327","metalloendopeptidase activity|protein kinase C binding|integrin binding|protein binding|collagen binding|extracellular space|plasma membrane|focal adhesion|membrane protein ectodomain proteolysis|cell adhesion|cell-matrix adhesion|transforming growth factor beta receptor signaling pathway|integrin-mediated signaling pathway|metallopeptidase activity|external side of plasma membrane|cell surface|response to manganese ion|basolateral plasma membrane|cell migration|SH3 domain binding|keratinocyte differentiation|positive regulation of cell migration|membrane protein intracellular domain proteolysis|cell adhesion mediated by integrin|positive regulation of cell adhesion mediated by integrin|cell-cell adhesion mediated by integrin|positive regulation of macrophage fusion|response to tumor necrosis factor|response to laminar fluid shear stress|monocyte activation|response to hydrogen peroxide|laminin binding|positive regulation of MAP kinase activity|metal ion binding|positive regulation of protein secretion|positive regulation of membrane protein ectodomain proteolysis|response to glucocorticoid|positive regulation of keratinocyte migration|response to calcium ion|extracellular exosome|cellular response to lipopolysaccharide|response to antineoplastic agent","WP3286,WP3888","Copper homeostasis|VEGFA-VEGFR2 signaling","R-HSA-1442490,R-HSA-1474228,R-HSA-1474244","Collagen degradation|Degradation of the extracellular matrix|Extracellular matrix organization"]
["ADAMTS1",63.0920021259375,45.7440741474996,34.189240359915,38.2775792862496,60.9901767940263,37.9869833796988,29.7159985647509,33.05805070019,34.521947775399,27.0693067762649,24.2942764679863,29.3492491116284,36.2937532034399,27.7522337356414,29.9204388058167,32.314377571687,41.2178119586822,40.0278859719847,30.3019025351208,38.6749489736031,35.0640540121901,35.707897761459,30.3187728059493,36.868661735228,39.5951014906196,32.4922127019293,29.2104070284109,29.1606129537931,9510,"ADAM metallopeptidase with thrombospondin type 1 motif 1","protein_coding",null,null,"GO:0001542,GO:0001822,GO:0004222,GO:0005515,GO:0005576,GO:0005604,GO:0006508,GO:0007229,GO:0008201,GO:0008237,GO:0008270,GO:0008285,GO:0016525,GO:0030198,GO:0031012,GO:0031410,GO:0060347,GO:0062023,GO:1900087,GO:1904707,GO:1904754","ovulation from ovarian follicle|kidney development|metalloendopeptidase activity|protein binding|extracellular region|basement membrane|proteolysis|integrin-mediated signaling pathway|heparin binding|metallopeptidase activity|zinc ion binding|negative regulation of cell population proliferation|negative regulation of angiogenesis|extracellular matrix organization|extracellular matrix|cytoplasmic vesicle|heart trabecula formation|collagen-containing extracellular matrix|positive regulation of G1/S transition of mitotic cell cycle|positive regulation of vascular associated smooth muscle cell proliferation|positive regulation of vascular associated smooth muscle cell migration","WP4808,WP474,WP5087,WP3888","Endochondral ossification with skeletal dysplasias|Endochondral ossification|Pleural mesothelioma|VEGFA-VEGFR2 signaling","R-HSA-1474228,R-HSA-1474244,R-HSA-1643685,R-HSA-3781865,R-HSA-3906995,R-HSA-392499,R-HSA-5083635,R-HSA-5173105,R-HSA-5173214,R-HSA-5668914,R-HSA-597592","Degradation of the extracellular matrix|Extracellular matrix organization|Disease|Diseases of glycosylation|Diseases associated with O-glycosylation of proteins|Metabolism of proteins|Defective B3GALTL causes PpS|O-linked glycosylation|O-glycosylation of TSR domain-containing proteins|Diseases of metabolism|Post-translational protein modification"]
["ADAMTS10",0.64465705168429,0.647241135705994,0.59401920453629,0.686959591301579,0.62409903316678,0.851996344594972,0.651580808176963,0.755066496896563,1.81922772882783,1.85116419196441,2.22857673170063,1.49533389327978,1.53833436094091,2.42426176740258,1.58763751152051,1.97518750548146,0.65997084379383,0.717983337944038,0.529605151810589,0.660095626228982,0.63663013997753,0.692203473131493,0.288745398736885,0.641475480147078,0.603620860679585,0.794033529479434,0.519852324079925,0.690226136994675,81794,"ADAM metallopeptidase with thrombospondin type 1 motif 10","protein_coding",null,null,"GO:0001527,GO:0003674,GO:0004222,GO:0005515,GO:0005576,GO:0006508,GO:0008150,GO:0030198,GO:0031012,GO:0046872,GO:0062023","microfibril|molecular_function|metalloendopeptidase activity|protein binding|extracellular region|proteolysis|biological_process|extracellular matrix organization|extracellular matrix|metal ion binding|collagen-containing extracellular matrix","WP4816","TGF-beta receptor signaling in skeletal dysplasias","R-HSA-1643685,R-HSA-3781865,R-HSA-3906995,R-HSA-392499,R-HSA-5083635,R-HSA-5173105,R-HSA-5173214,R-HSA-5668914,R-HSA-597592","Disease|Diseases of glycosylation|Diseases associated with O-glycosylation of proteins|Metabolism of proteins|Defective B3GALTL causes PpS|O-linked glycosylation|O-glycosylation of TSR domain-containing proteins|Diseases of metabolism|Post-translational protein modification"]
["ADAMTS12",1.25298634283073,1.05967550663671,0.683985397166213,0.864562016294302,1.52630180145462,0.910414855129826,0.584512471288741,0.822822743036197,0.627315769685982,0.61158408214909,0.466545730655543,0.684493230844236,0.6631864477996,0.510799899665234,0.324272048949312,0.43542865212302,1.42543587255062,1.0754097164659,0.534478477163773,1.13402187290652,1.45019740774606,0.961969373125608,0.537327795522584,1.11335205295879,1.49518450140427,0.910430067504202,0.592529964171612,0.930102479635566,81792,"ADAM metallopeptidase with thrombospondin type 1 motif 12","protein_coding",null,null,"GO:0002062,GO:0004222,GO:0005515,GO:0005576,GO:0006508,GO:0007160,GO:0016477,GO:0030167,GO:0030198,GO:0030199,GO:0031012,GO:0032331,GO:0043931,GO:0046872,GO:0050727,GO:0051603,GO:0071347,GO:0071356,GO:0071773,GO:1901509,GO:1902203,GO:1902548,GO:2001113","chondrocyte differentiation|metalloendopeptidase activity|protein binding|extracellular region|proteolysis|cell-matrix adhesion|cell migration|proteoglycan catabolic process|extracellular matrix organization|collagen fibril organization|extracellular matrix|negative regulation of chondrocyte differentiation|ossification involved in bone maturation|metal ion binding|regulation of inflammatory response|proteolysis involved in protein catabolic process|cellular response to interleukin-1|cellular response to tumor necrosis factor|cellular response to BMP stimulus|regulation of endothelial tube morphogenesis|negative regulation of hepatocyte growth factor receptor signaling pathway|negative regulation of cellular response to vascular endothelial growth factor stimulus|negative regulation of cellular response to hepatocyte growth factor stimulus",null,null,"R-HSA-1643685,R-HSA-3781865,R-HSA-3906995,R-HSA-392499,R-HSA-5083635,R-HSA-5173105,R-HSA-5173214,R-HSA-5668914,R-HSA-597592","Disease|Diseases of glycosylation|Diseases associated with O-glycosylation of proteins|Metabolism of proteins|Defective B3GALTL causes PpS|O-linked glycosylation|O-glycosylation of TSR domain-containing proteins|Diseases of metabolism|Post-translational protein modification"]
["ADAMTS13",1.14630481663347,1.17617851305204,0.809262481462184,1.15996839923713,1.08925134248033,1.33071548343416,0.892646901229548,1.08865937259824,1.47079067308787,1.98639991418238,1.62978279158744,1.79802379339719,1.24463172373013,1.95768461772163,1.37664062211463,1.86565274096033,0.572746256175438,1.06898693487842,0.65067929123757,1.0545731430221,0.843403426041713,0.857956675164421,0.556916934323406,0.696635947214563,0.926180925297177,0.909092522129791,0.519691795244987,0.780666477711903,11093,"ADAM metallopeptidase with thrombospondin type 1 motif 13","protein_coding",null,null,"GO:0004222,GO:0005178,GO:0005509,GO:0005515,GO:0005615,GO:0005788,GO:0006508,GO:0007160,GO:0007229,GO:0008237,GO:0008270,GO:0009100,GO:0009636,GO:0009986,GO:0014075,GO:0016485,GO:0030163,GO:0030168,GO:0030198,GO:0031012,GO:0035864,GO:0043171,GO:0071222,GO:0071346,GO:0071353,GO:0071356","metalloendopeptidase activity|integrin binding|calcium ion binding|protein binding|extracellular space|endoplasmic reticulum lumen|proteolysis|cell-matrix adhesion|integrin-mediated signaling pathway|metallopeptidase activity|zinc ion binding|glycoprotein metabolic process|response to toxic substance|cell surface|response to amine|protein processing|protein catabolic process|platelet activation|extracellular matrix organization|extracellular matrix|response to potassium ion|peptide catabolic process|cellular response to lipopolysaccharide|cellular response to type II interferon|cellular response to interleukin-4|cellular response to tumor necrosis factor",null,null,"R-HSA-1643685,R-HSA-3781865,R-HSA-3906995,R-HSA-392499,R-HSA-5083635,R-HSA-5173105,R-HSA-5173214,R-HSA-5668914,R-HSA-597592","Disease|Diseases of glycosylation|Diseases associated with O-glycosylation of proteins|Metabolism of proteins|Defective B3GALTL causes PpS|O-linked glycosylation|O-glycosylation of TSR domain-containing proteins|Diseases of metabolism|Post-translational protein modification"]
["ADAMTS14",0.335073273043659,0.277849983758554,0.145190207015999,0.234836178374664,0.453350073721364,0.314650879000723,0.164326075007748,0.273809839092025,1.06296691841378,1.50601971081721,1.06654998760627,1.21446597816699,0.955955134983693,0.708526697901381,0.415488359407556,0.67613153785281,0.231289085760726,0.377602466006437,0.111167848997585,0.218939986761343,0.316259483900581,0.261332919624266,0.110263695383657,0.247616505370964,0.438673597536735,0.306134497933619,0.0789825742635748,0.274622050280077,140766,"ADAM metallopeptidase with thrombospondin type 1 motif 14","protein_coding",null,null,"GO:0004222,GO:0005576,GO:0006508,GO:0030198,GO:0030199,GO:0030574,GO:0031012,GO:0046872","metalloendopeptidase activity|extracellular region|proteolysis|extracellular matrix organization|collagen fibril organization|collagen catabolic process|extracellular matrix|metal ion binding",null,null,"R-HSA-1474244,R-HSA-1474290,R-HSA-1643685,R-HSA-1650814,R-HSA-3781865,R-HSA-3906995,R-HSA-392499,R-HSA-5083635,R-HSA-5173105,R-HSA-5173214,R-HSA-5668914,R-HSA-597592","Extracellular matrix organization|Collagen formation|Disease|Collagen biosynthesis and modifying enzymes|Diseases of glycosylation|Diseases associated with O-glycosylation of proteins|Metabolism of proteins|Defective B3GALTL causes PpS|O-linked glycosylation|O-glycosylation of TSR domain-containing proteins|Diseases of metabolism|Post-translational protein modification"]
["ADAMTS15",0.198493020781364,0.377599590447682,0.303835357313308,0.384871117912021,0.278289035080102,0.214759527821899,0.305969714911724,0.283499776139352,0.00868074225292723,0.0207798065827157,0.00811613959213073,0.00868262917146609,0.0246215351451678,0.0246833209892073,0.0401298693416288,0.0327307017731991,0.0248920455501251,0.00399257828884667,0.0159523028758912,0.00414945865918261,0.00407278213845446,0.0123048868755172,0.00851983953568422,0.00421570101771643,0.00855611260253237,0.0328007081719602,0.00835121959178607,0.0081133219969467,170689,"ADAM metallopeptidase with thrombospondin type 1 motif 15","protein_coding",null,null,"GO:0004175,GO:0004222,GO:0005615,GO:0006508,GO:0007520,GO:0008201,GO:0008270,GO:0009986,GO:0022617,GO:0030198,GO:0031012,GO:0050840,GO:0062023","endopeptidase activity|metalloendopeptidase activity|extracellular space|proteolysis|myoblast fusion|heparin binding|zinc ion binding|cell surface|extracellular matrix disassembly|extracellular matrix organization|extracellular matrix|extracellular matrix binding|collagen-containing extracellular matrix",null,null,"R-HSA-1643685,R-HSA-3781865,R-HSA-3906995,R-HSA-392499,R-HSA-5083635,R-HSA-5173105,R-HSA-5173214,R-HSA-5668914,R-HSA-597592","Disease|Diseases of glycosylation|Diseases associated with O-glycosylation of proteins|Metabolism of proteins|Defective B3GALTL causes PpS|O-linked glycosylation|O-glycosylation of TSR domain-containing proteins|Diseases of metabolism|Post-translational protein modification"]
["ADAMTS16",0,0.00514959491063919,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,170690,"ADAM metallopeptidase with thrombospondin type 1 motif 16","protein_coding",null,null,"GO:0001658,GO:0003073,GO:0004222,GO:0005576,GO:0006508,GO:0030198,GO:0031012,GO:0046872,GO:0048232,GO:1902017","branching involved in ureteric bud morphogenesis|regulation of systemic arterial blood pressure|metalloendopeptidase activity|extracellular region|proteolysis|extracellular matrix organization|extracellular matrix|metal ion binding|male gamete generation|regulation of cilium assembly",null,null,"R-HSA-1474228,R-HSA-1474244,R-HSA-1643685,R-HSA-3781865,R-HSA-3906995,R-HSA-392499,R-HSA-5083635,R-HSA-5173105,R-HSA-5173214,R-HSA-5668914,R-HSA-597592","Degradation of the extracellular matrix|Extracellular matrix organization|Disease|Diseases of glycosylation|Diseases associated with O-glycosylation of proteins|Metabolism of proteins|Defective B3GALTL causes PpS|O-linked glycosylation|O-glycosylation of TSR domain-containing proteins|Diseases of metabolism|Post-translational protein modification"]
["ADAMTS17",0.0060062868171219,0.0182815208984474,0.0101500506798729,0.0103686815318112,0.0117381812925066,0.00564020940665003,0.00448304908775106,0.0153133399313944,0.0205411351719834,0.0312380498796799,0.0101674179208637,0.0145027765866707,0.0045695404055812,0.0183240292596052,0.0134059515388853,0.0296133358032896,0.0080845533263623,1.11148113058935E-3,0.0155431874434012,0.0127067001195655,0.0102042794193549,0.00685103639138648,3.55771641573658E-3,0.0105623599963935,0.0047638177743333,0.00228282112244023,0.0058121734391586,0.00790524638156155,170691,"ADAM metallopeptidase with thrombospondin type 1 motif 17","protein_coding",null,null,"GO:0004222,GO:0005576,GO:0006508,GO:0030198,GO:0031012,GO:0046872","metalloendopeptidase activity|extracellular region|proteolysis|extracellular matrix organization|extracellular matrix|metal ion binding",null,null,"R-HSA-1643685,R-HSA-3781865,R-HSA-3906995,R-HSA-392499,R-HSA-5083635,R-HSA-5173105,R-HSA-5173214,R-HSA-5668914,R-HSA-597592","Disease|Diseases of glycosylation|Diseases associated with O-glycosylation of proteins|Metabolism of proteins|Defective B3GALTL causes PpS|O-linked glycosylation|O-glycosylation of TSR domain-containing proteins|Diseases of metabolism|Post-translational protein modification"]
["ADAMTS18",0,0,0,0,0,0.00433372022205878,0,0,0,0,0,0,0.00438882411835483,0,0,0,0.00443704298783403,0,0,0,0,0,0,0,0,0,0,0.0043386340108651,170692,"ADAM metallopeptidase with thrombospondin type 1 motif 18","protein_coding",null,null,"GO:0001654,GO:0004222,GO:0005576,GO:0006508,GO:0030198,GO:0031012,GO:0046872,GO:0090331","eye development|metalloendopeptidase activity|extracellular region|proteolysis|extracellular matrix organization|extracellular matrix|metal ion binding|negative regulation of platelet aggregation",null,null,"R-HSA-1474228,R-HSA-1474244,R-HSA-1643685,R-HSA-3781865,R-HSA-3906995,R-HSA-392499,R-HSA-5083635,R-HSA-5173105,R-HSA-5173214,R-HSA-5668914,R-HSA-597592","Degradation of the extracellular matrix|Extracellular matrix organization|Disease|Diseases of glycosylation|Diseases associated with O-glycosylation of proteins|Metabolism of proteins|Defective B3GALTL causes PpS|O-linked glycosylation|O-glycosylation of TSR domain-containing proteins|Diseases of metabolism|Post-translational protein modification"]
["ADAMTS19",0.0893872506971696,0.0510132635217537,0.0447573068555762,0.0657244748068535,0.142664249165342,0.123110802691499,0.0416987488376535,0.067200525506894,0.254749128583679,0.175052471649292,0.184939791428909,0.206841302418274,0.37686207392686,0.230093460148591,0.324205608178701,0.262733344477137,0.214851067414103,0.209524083049885,0.09638253736872,0.240678692659307,0.174361173999486,0.147274185630246,0.179431286191255,0.253253800200916,0.245183648752384,0.147218874287225,0.172996801558154,0.14285840876872,171019,"ADAM metallopeptidase with thrombospondin type 1 motif 19","protein_coding",null,null,"GO:0004222,GO:0005576,GO:0006508,GO:0030198,GO:0031012,GO:0046872","metalloendopeptidase activity|extracellular region|proteolysis|extracellular matrix organization|extracellular matrix|metal ion binding",null,null,"R-HSA-1643685,R-HSA-3781865,R-HSA-3906995,R-HSA-392499,R-HSA-5083635,R-HSA-5173105,R-HSA-5173214,R-HSA-5668914,R-HSA-597592","Disease|Diseases of glycosylation|Diseases associated with O-glycosylation of proteins|Metabolism of proteins|Defective B3GALTL causes PpS|O-linked glycosylation|O-glycosylation of TSR domain-containing proteins|Diseases of metabolism|Post-translational protein modification"]
["ADAMTS19-AS1",0.0685908784611784,0.130482610992735,0.160988929358459,0,0.0335120595679196,0.193230990969812,0.0319973350919636,0.0336300007888522,0.034496562884247,0.0990927112383399,0.161264389414887,0.0690081226897566,0.032614658619988,0,0.159472833191574,0.0325172859378459,0.0659459747886478,0.031732362048887,0,0.0659584433687373,0.0971094275531489,0.0651981580248994,0.0677142971748337,0.201034230974615,0.0680025896030785,0.0325868358699484,0.165935333301169,0.483625214837081,103689846,"ADAMTS19 antisense RNA 1","non_coding"]
["ADAMTS2",7.45362032978879,7.73509808420576,6.21173658408795,7.26517962148154,8.11945529926488,8.22533753803294,5.87370207792555,7.2185837347921,8.58798753024314,10.6420880930301,8.06410202315602,8.50822284221528,8.389548645142,8.49498887733161,6.57168585137541,8.03579591530217,4.25149882914685,4.95147279568846,4.10055429562963,4.68498067453962,5.09967322174376,4.67304608651607,3.25501116404439,4.1868699832286,4.73876357331465,4.48906513682193,2.94076731993893,4.3687058673421,9509,"ADAM metallopeptidase with thrombospondin type 1 motif 2","protein_coding",null,null,"GO:0004222,GO:0005576,GO:0006508,GO:0007283,GO:0008237,GO:0008270,GO:0016485,GO:0030198,GO:0030199,GO:0030324,GO:0030574,GO:0031012,GO:0043588,GO:0062023","metalloendopeptidase activity|extracellular region|proteolysis|spermatogenesis|metallopeptidase activity|zinc ion binding|protein processing|extracellular matrix organization|collagen fibril organization|lung development|collagen catabolic process|extracellular matrix|skin development|collagen-containing extracellular matrix","WP4786,WP5312","Type I collagen synthesis in the context of osteogenesis imperfecta|Metabolic pathways of fibroblasts","R-HSA-1474244,R-HSA-1474290,R-HSA-1643685,R-HSA-1650814,R-HSA-3781865,R-HSA-3906995,R-HSA-392499,R-HSA-5083635,R-HSA-5173105,R-HSA-5173214,R-HSA-5668914,R-HSA-597592","Extracellular matrix organization|Collagen formation|Disease|Collagen biosynthesis and modifying enzymes|Diseases of glycosylation|Diseases associated with O-glycosylation of proteins|Metabolism of proteins|Defective B3GALTL causes PpS|O-linked glycosylation|O-glycosylation of TSR domain-containing proteins|Diseases of metabolism|Post-translational protein modification"]
["ADAMTS20",0,0.00334156562753454,0,0,0,0,0,0,0.0212023707235904,0.0135343622283044,0.0165194591528869,0.0176724828731098,0.0233866612442557,0.0334933546677914,0.0228703122173867,0.0233168392063115,0.0101329733188864,0.0065011433781898,0.00324690590595896,0.0236480747696333,0.00331586993599961,0.00333935567623947,0,0,0,0,0.00679917487161313,0.0297247036774622,80070,"ADAM metallopeptidase with thrombospondin type 1 motif 20","protein_coding",null,null,"GO:0004222,GO:0005615,GO:0006508,GO:0006915,GO:0007165,GO:0008270,GO:0009967,GO:0030198,GO:0030318,GO:0031012,GO:0043066,GO:0045636,GO:0062023","metalloendopeptidase activity|extracellular space|proteolysis|apoptotic process|signal transduction|zinc ion binding|positive regulation of signal transduction|extracellular matrix organization|melanocyte differentiation|extracellular matrix|negative regulation of apoptotic process|positive regulation of melanocyte differentiation|collagen-containing extracellular matrix","WP2840","Hair follicle development: cytodifferentiation - part 3 of 3","R-HSA-1643685,R-HSA-3781865,R-HSA-3906995,R-HSA-392499,R-HSA-5083635,R-HSA-5173105,R-HSA-5173214,R-HSA-5668914,R-HSA-597592","Disease|Diseases of glycosylation|Diseases associated with O-glycosylation of proteins|Metabolism of proteins|Defective B3GALTL causes PpS|O-linked glycosylation|O-glycosylation of TSR domain-containing proteins|Diseases of metabolism|Post-translational protein modification"]
["ADAMTS3",0.564467754926031,0.482116519078287,0.356900072623908,0.441924432239022,0.510299874582954,0.483187580553287,0.340347722409819,0.338886931026126,1.69560926060697,0.980057968843012,0.996696626270886,1.525993721616,1.79299782657799,1.01040576725079,1.47843583509604,1.6565750669447,0.826973796665846,0.763882031715301,0.766569508197634,0.91575124280493,0.895205056221436,0.700796611385585,1.21686064551236,0.911612916611812,0.98600848830891,0.784451480578715,1.01813382111319,0.595644388530114,9508,"ADAM metallopeptidase with thrombospondin type 1 motif 3","protein_coding",null,null,"GO:0001701,GO:0004175,GO:0004222,GO:0005515,GO:0005576,GO:0005615,GO:0006508,GO:0008201,GO:0008270,GO:0010573,GO:0016485,GO:0030198,GO:0030199,GO:0030574,GO:0031012,GO:0032964,GO:0062023,GO:0070062,GO:0097435,GO:1900748","in utero embryonic development|endopeptidase activity|metalloendopeptidase activity|protein binding|extracellular region|extracellular space|proteolysis|heparin binding|zinc ion binding|vascular endothelial growth factor production|protein processing|extracellular matrix organization|collagen fibril organization|collagen catabolic process|extracellular matrix|collagen biosynthetic process|collagen-containing extracellular matrix|extracellular exosome|supramolecular fiber organization|positive regulation of vascular endothelial growth factor signaling pathway",null,null,"R-HSA-1474244,R-HSA-1474290,R-HSA-1643685,R-HSA-1650814,R-HSA-3781865,R-HSA-3906995,R-HSA-392499,R-HSA-5083635,R-HSA-5173105,R-HSA-5173214,R-HSA-5668914,R-HSA-597592","Extracellular matrix organization|Collagen formation|Disease|Collagen biosynthesis and modifying enzymes|Diseases of glycosylation|Diseases associated with O-glycosylation of proteins|Metabolism of proteins|Defective B3GALTL causes PpS|O-linked glycosylation|O-glycosylation of TSR domain-containing proteins|Diseases of metabolism|Post-translational protein modification"]
["ADAMTS4",0.603805987165617,0.503513137724652,0.318381665388507,0.341104912334231,0.528048874787299,0.502278040759619,0.277814235582143,0.400134062776475,0.543561674511155,0.509845529930802,0.420049447335102,0.590835731025553,0.613543875628789,0.533598093528593,0.397434290022082,0.457477005293107,0.408221569618343,0.489802006906171,0.298136499429426,0.485186180693077,0.408560825710466,0.421937511783722,0.209583956920082,0.323233927679344,0.464687839969487,0.458455484699949,0.322827980135849,0.404351637124295,9507,"ADAM metallopeptidase with thrombospondin type 1 motif 4","protein_coding",null,null,"GO:0001501,GO:0002020,GO:0004222,GO:0005515,GO:0005576,GO:0005615,GO:0006508,GO:0008233,GO:0008237,GO:0008270,GO:0016607,GO:0022617,GO:0030198,GO:0031012,GO:0062023","skeletal system development|protease binding|metalloendopeptidase activity|protein binding|extracellular region|extracellular space|proteolysis|peptidase activity|metallopeptidase activity|zinc ion binding|nuclear speck|extracellular matrix disassembly|extracellular matrix organization|extracellular matrix|collagen-containing extracellular matrix","WP4808,WP474","Endochondral ossification with skeletal dysplasias|Endochondral ossification","R-HSA-1474228,R-HSA-1474228,R-HSA-1474244,R-HSA-1474244,R-HSA-1643685,R-HSA-3781865,R-HSA-3906995,R-HSA-392499,R-HSA-5083635,R-HSA-5173105,R-HSA-5173214,R-HSA-5668914,R-HSA-597592","Degradation of the extracellular matrix|Degradation of the extracellular matrix|Extracellular matrix organization|Extracellular matrix organization|Disease|Diseases of glycosylation|Diseases associated with O-glycosylation of proteins|Metabolism of proteins|Defective B3GALTL causes PpS|O-linked glycosylation|O-glycosylation of TSR domain-containing proteins|Diseases of metabolism|Post-translational protein modification"]
["ADAMTS5",3.13255957452234,2.38109850197227,1.74175764481746,1.66013858167851,3.95819657689614,2.49278044481623,1.65028932332154,2.01254430687525,1.51842244246675,0.816685951528326,0.579039645326852,0.866694181250923,1.79769436713257,1.13024033310617,1.30594542941415,1.54652237981133,2.33931156590229,1.8989825479386,1.31281363881372,2.47998328721074,2.4239610486874,1.94058248191362,2.00747588145175,2.43778676157997,2.46313527318063,1.63450632709251,1.64893375107288,1.42424767235391,11096,"ADAM metallopeptidase with thrombospondin type 1 motif 5","protein_coding",null,null,"GO:0003180,GO:0003184,GO:0003203,GO:0004175,GO:0004222,GO:0005178,GO:0005515,GO:0005576,GO:0005615,GO:0005788,GO:0006508,GO:0007520,GO:0008201,GO:0008233,GO:0008237,GO:0008270,GO:0022617,GO:0030198,GO:0031012,GO:0042742,GO:0042802,GO:0050840,GO:0062023,GO:0120163","aortic valve morphogenesis|pulmonary valve morphogenesis|endocardial cushion morphogenesis|endopeptidase activity|metalloendopeptidase activity|integrin binding|protein binding|extracellular region|extracellular space|endoplasmic reticulum lumen|proteolysis|myoblast fusion|heparin binding|peptidase activity|metallopeptidase activity|zinc ion binding|extracellular matrix disassembly|extracellular matrix organization|extracellular matrix|defense response to bacterium|identical protein binding|extracellular matrix binding|collagen-containing extracellular matrix|negative regulation of cold-induced thermogenesis","WP4808,WP4754,WP474,WP2877","Endochondral ossification with skeletal dysplasias|IL-18 signaling pathway|Endochondral ossification|Vitamin D receptor pathway","R-HSA-1474228,R-HSA-1474228,R-HSA-1474244,R-HSA-1474244,R-HSA-1643685,R-HSA-3781865,R-HSA-3906995,R-HSA-392499,R-HSA-5083635,R-HSA-5173105,R-HSA-5173214,R-HSA-5668914,R-HSA-597592","Degradation of the extracellular matrix|Degradation of the extracellular matrix|Extracellular matrix organization|Extracellular matrix organization|Disease|Diseases of glycosylation|Diseases associated with O-glycosylation of proteins|Metabolism of proteins|Defective B3GALTL causes PpS|O-linked glycosylation|O-glycosylation of TSR domain-containing proteins|Diseases of metabolism|Post-translational protein modification"]
["ADAMTS6",1.68476345220269,1.90772567411254,1.65002955653593,1.46726986534509,1.91063273835571,1.56806253711625,1.55620261709312,1.4581426463296,1.66837010670121,1.21653312314433,1.0229439545501,1.3458733263872,1.66429569016066,1.5243929636187,1.45403726595553,1.70532098728195,2.26197706007299,2.1665112054183,1.78298507218864,2.44002414256109,2.3966966982113,2.11218476187766,2.45708976089927,2.58287522100809,2.26222983556437,1.98020512140446,2.25680322492246,1.76278177351539,11174,"ADAM metallopeptidase with thrombospondin type 1 motif 6","protein_coding",null,null,"GO:0001822,GO:0003279,GO:0004222,GO:0005576,GO:0006508,GO:0008237,GO:0030198,GO:0031012,GO:0035904,GO:0046872,GO:0060976","kidney development|cardiac septum development|metalloendopeptidase activity|extracellular region|proteolysis|metallopeptidase activity|extracellular matrix organization|extracellular matrix|aorta development|metal ion binding|coronary vasculature development",null,null,"R-HSA-1643685,R-HSA-3781865,R-HSA-3906995,R-HSA-392499,R-HSA-5083635,R-HSA-5173105,R-HSA-5173214,R-HSA-5668914,R-HSA-597592","Disease|Diseases of glycosylation|Diseases associated with O-glycosylation of proteins|Metabolism of proteins|Defective B3GALTL causes PpS|O-linked glycosylation|O-glycosylation of TSR domain-containing proteins|Diseases of metabolism|Post-translational protein modification"]
["ADAMTS7",2.07041168052397,2.34070903125472,2.21232467269374,3.0350762611302,2.87939544457297,2.85664208816243,2.01216187579326,2.2840191440255,3.92305581081499,6.06530178671809,5.14530372735464,3.98786050286439,3.89902558073192,4.41959567262335,4.11273909615882,4.46855533830865,1.71556170795551,1.94088531169554,1.2295196465912,1.96475504627946,2.23271535790128,1.60116001928657,1.05783487188335,1.47712923325006,1.89060256693349,1.66958546548638,0.755705897916512,2.01472220204186,11173,"ADAM metallopeptidase with thrombospondin type 1 motif 7","protein_coding",null,null,"GO:0002062,GO:0004222,GO:0005515,GO:0005576,GO:0005788,GO:0006029,GO:0006508,GO:0008237,GO:0009986,GO:0030198,GO:0030199,GO:0031012,GO:0032331,GO:0043931,GO:0046872,GO:0051603,GO:0071347,GO:0071356,GO:0071773","chondrocyte differentiation|metalloendopeptidase activity|protein binding|extracellular region|endoplasmic reticulum lumen|proteoglycan metabolic process|proteolysis|metallopeptidase activity|cell surface|extracellular matrix organization|collagen fibril organization|extracellular matrix|negative regulation of chondrocyte differentiation|ossification involved in bone maturation|metal ion binding|proteolysis involved in protein catabolic process|cellular response to interleukin-1|cellular response to tumor necrosis factor|cellular response to BMP stimulus",null,null,"R-HSA-1643685,R-HSA-3781865,R-HSA-3906995,R-HSA-392499,R-HSA-5083635,R-HSA-5173105,R-HSA-5173214,R-HSA-5668914,R-HSA-597592","Disease|Diseases of glycosylation|Diseases associated with O-glycosylation of proteins|Metabolism of proteins|Defective B3GALTL causes PpS|O-linked glycosylation|O-glycosylation of TSR domain-containing proteins|Diseases of metabolism|Post-translational protein modification"]
["ADAMTS8",0,0,0,0,0,0,0,0.0145717643991388,0.00747362139664228,0.028624355396301,0.00698753087541906,0.00747524592532369,0,7.0836414103077E-3,0,0.00704481442865129,0.0142870827408702,0,0,0,0.00701286384204107,0.014125069516971,0.00733509338194864,0.0145179075290378,0.0441979344774143,0.0282395292103411,0,0.0279404203500143,11095,"ADAM metallopeptidase with thrombospondin type 1 motif 8","protein_coding",null,null,"GO:0004222,GO:0005178,GO:0005576,GO:0006508,GO:0008201,GO:0008237,GO:0008270,GO:0008285,GO:0009673,GO:0030198,GO:0031012,GO:0035435,GO:0062023","metalloendopeptidase activity|integrin binding|extracellular region|proteolysis|heparin binding|metallopeptidase activity|zinc ion binding|negative regulation of cell population proliferation|low-affinity phosphate transmembrane transporter activity|extracellular matrix organization|extracellular matrix|phosphate ion transmembrane transport|collagen-containing extracellular matrix",null,null,"R-HSA-1474228,R-HSA-1474244,R-HSA-1643685,R-HSA-3781865,R-HSA-3906995,R-HSA-392499,R-HSA-5083635,R-HSA-5173105,R-HSA-5173214,R-HSA-5668914,R-HSA-597592","Degradation of the extracellular matrix|Extracellular matrix organization|Disease|Diseases of glycosylation|Diseases associated with O-glycosylation of proteins|Metabolism of proteins|Defective B3GALTL causes PpS|O-linked glycosylation|O-glycosylation of TSR domain-containing proteins|Diseases of metabolism|Post-translational protein modification"]
["ADAMTS9",0.668248252814919,0.797040980487564,0.57094478850548,0.627325179421145,0.798091632674304,0.620878749447466,0.679548860014479,0.741959686868847,1.72487339154037,1.52899637521718,1.3899027443201,1.82129307648768,1.73501085840244,2.18431850363515,1.64409295499183,2.16564100716905,0.577892258083625,0.408932918586457,0.51630829283773,0.748001969262989,0.684122160792186,0.722575860744212,0.603859830878773,0.666677395295277,0.687054495270977,0.493854694397374,0.513215524559492,0.551779324336157,56999,"ADAM metallopeptidase with thrombospondin type 1 motif 9","protein_coding",null,null,"GO:0003179,GO:0003229,GO:0004222,GO:0005615,GO:0005783,GO:0006508,GO:0008237,GO:0008270,GO:0009617,GO:0009986,GO:0010596,GO:0015031,GO:0016192,GO:0030198,GO:0030318,GO:0031012,GO:0035909,GO:0043231,GO:0045636,GO:0062023,GO:0090673,GO:1903671","heart valve morphogenesis|ventricular cardiac muscle tissue development|metalloendopeptidase activity|extracellular space|endoplasmic reticulum|proteolysis|metallopeptidase activity|zinc ion binding|response to bacterium|cell surface|negative regulation of endothelial cell migration|protein transport|vesicle-mediated transport|extracellular matrix organization|melanocyte differentiation|extracellular matrix|aorta morphogenesis|intracellular membrane-bounded organelle|positive regulation of melanocyte differentiation|collagen-containing extracellular matrix|endothelial cell-matrix adhesion|negative regulation of sprouting angiogenesis","WP3888","VEGFA-VEGFR2 signaling","R-HSA-1474228,R-HSA-1474244,R-HSA-1643685,R-HSA-3781865,R-HSA-3906995,R-HSA-392499,R-HSA-5083635,R-HSA-5173105,R-HSA-5173214,R-HSA-5668914,R-HSA-597592","Degradation of the extracellular matrix|Extracellular matrix organization|Disease|Diseases of glycosylation|Diseases associated with O-glycosylation of proteins|Metabolism of proteins|Defective B3GALTL causes PpS|O-linked glycosylation|O-glycosylation of TSR domain-containing proteins|Diseases of metabolism|Post-translational protein modification"]
["ADAMTS9-AS1",0,0,0,0,0.0134048238271678,0.0128820660646541,0.00639946701839273,0.00672600015777044,0.0413958754610965,0.0660618074922266,0.025802302306382,0.0276032490759026,0.0130458634479952,0,0.0191367399829889,0.0650345718756918,0,0,0,0,6.47396183687659E-3,0.0195594474074698,0,0,0.00680025896030785,0,0,0,101929335,"ADAMTS9 antisense RNA 1","non_coding"]
["ADAMTS9-AS2",0.375064036037942,0.529368187057152,0.431635308983705,0.150845390806901,0.803928437965067,0.397649952242633,0.406371900252336,0.427107047720539,0.389433370585539,0.50106754255437,0.432373858441998,0.718173851349814,0.897459376424696,0.853572431197544,1.08017792650838,0.975080733172121,0.418762859654303,0.447785216704222,0.257186134370615,0.244324521149995,0.308326791073148,0.207007078037764,0.334438117644466,0.330966588516556,0.395837335979499,0.402362591913052,0.573683431486645,0.545966849352884,100507098,"ADAMTS9 antisense RNA 2","non_coding"]
["ADAMTSL1",2.41521409664632,2.8662139127503,2.57562685356938,2.14867916776034,2.77255966408321,2.84422413772783,2.66166503494344,2.42199206581165,3.41141605407869,3.57914934384995,2.46708051029384,2.79839992922785,3.90724128234506,4.18120590360717,3.7280763689906,4.50105339220974,1.81216152398635,1.91782568123571,1.28590107416689,2.03206301700347,1.73411528053816,1.75770126792775,1.31602862022518,1.60559551985646,1.89815063170795,1.64630799417401,1.31069587858836,1.58415206907645,92949,"ADAMTS like 1","protein_coding",null,null,"GO:0005576,GO:0005788,GO:0016787,GO:0030198","extracellular region|endoplasmic reticulum lumen|hydrolase activity|extracellular matrix organization",null,null,"R-HSA-1643685,R-HSA-3781865,R-HSA-3906995,R-HSA-392499,R-HSA-5083635,R-HSA-5173105,R-HSA-5173214,R-HSA-5668914,R-HSA-597592","Disease|Diseases of glycosylation|Diseases associated with O-glycosylation of proteins|Metabolism of proteins|Defective B3GALTL causes PpS|O-linked glycosylation|O-glycosylation of TSR domain-containing proteins|Diseases of metabolism|Post-translational protein modification"]
["ADAMTSL3",0,2.57920058948521E-3,0,0.00260060147731443,0,0,0,0,0,0.00522327539371191,0,0.00272811510080216,0.00257872665479434,0,0,0,0,0,0.00250613711059482,0.00521510275503747,0.0102374690751131,0,0,0.00529835715877167,0,0,0,0,57188,"ADAMTS like 3","protein_coding",null,null,"GO:0005515,GO:0005576,GO:0030198,GO:0031012,GO:0043231","protein binding|extracellular region|extracellular matrix organization|extracellular matrix|intracellular membrane-bounded organelle","WP5408","15q25 copy number variation","R-HSA-1643685,R-HSA-3781865,R-HSA-3906995,R-HSA-392499,R-HSA-5083635,R-HSA-5173105,R-HSA-5173214,R-HSA-5668914,R-HSA-597592","Disease|Diseases of glycosylation|Diseases associated with O-glycosylation of proteins|Metabolism of proteins|Defective B3GALTL causes PpS|O-linked glycosylation|O-glycosylation of TSR domain-containing proteins|Diseases of metabolism|Post-translational protein modification"]
["ADAMTSL4",4.26146049674799,5.33534761470627,4.69397552066291,5.36536066431517,5.53440575215071,6.12357535279994,4.07761333587757,5.36923981344518,4.74998647076256,5.83197036781468,4.57618534921544,4.45189920033959,4.45315992337656,5.8248939573756,4.11981648229369,5.03654503546718,2.46780990287209,3.51200250237972,2.445554010068,2.84471248926774,2.92777783673659,2.90612399927125,1.81488008657762,2.2268975659063,2.77566820007639,3.26286476556786,1.96596766579539,2.91153047535191,54507,"ADAMTS like 4","protein_coding",null,null,"GO:0002020,GO:0002064,GO:0005515,GO:0005576,GO:0005614,GO:0005788,GO:0006915,GO:0030198,GO:0043065,GO:0062023,GO:0070285","protease binding|epithelial cell development|protein binding|extracellular region|interstitial matrix|endoplasmic reticulum lumen|apoptotic process|extracellular matrix organization|positive regulation of apoptotic process|collagen-containing extracellular matrix|pigment cell development",null,null,"R-HSA-1643685,R-HSA-3781865,R-HSA-3906995,R-HSA-392499,R-HSA-5083635,R-HSA-5173105,R-HSA-5173214,R-HSA-5668914,R-HSA-597592","Disease|Diseases of glycosylation|Diseases associated with O-glycosylation of proteins|Metabolism of proteins|Defective B3GALTL causes PpS|O-linked glycosylation|O-glycosylation of TSR domain-containing proteins|Diseases of metabolism|Post-translational protein modification"]
["ADAMTSL4-AS1",0.312234153303974,0.494977472202172,0.0977121995951733,0.374313406650329,0.508503452130981,0.342071078608721,0.0971038817848782,0.357205143514024,0.732818876405897,0.250601258151014,0.146819085034866,0.157066750291936,0.420653541004131,0.297677039033934,0.120990006649206,0.148022703168804,0.250161854169291,0.361124081618125,0.408812406640148,0.175146407053471,0.0736756853829875,0.222592553025163,0.256869872487545,0.482986680401368,0.257963491447971,0.0494464343509256,0.100714418513296,0.171229467955831,574406,"ADAMTSL4 antisense RNA 1","non_coding",{"$nulls":4},"WP3614,WP5413,WP4399,WP5366,WP3872,WP4864,WP3657,WP254,WP3611,WP1772,WP5087,WP4172","Photodynamic therapy-induced HIF-1 survival signaling|IL-24 Signaling pathway|MicroRNA network associated with chronic lymphocytic leukemia|NF1 copy number variation syndrome |Regulation of apoptosis by parathyroid hormone-related protein|Host-pathogen interaction of human coronaviruses - apoptosis|Hematopoietic stem cell gene regulation by GABP alpha/beta complex|Apoptosis|Photodynamic therapy-induced AP-1 survival signaling|Apoptosis modulation and signaling|Pleural mesothelioma|PI3K-Akt signaling pathway"]
["ADAMTSL4-AS2",0.898540507841437,0.427330551001208,0.210895497459582,0.769422002559011,0.909373673560905,0.210943831808711,0.269463271953037,0.409084938167252,0.451904973783636,0.556334793095251,0.120717914362001,0.419717260502341,0.213626013960921,0.0917837537021298,0.35813041968165,0.395549556801083,0.123413181390183,0.148462122443007,0.207612575136859,0.308591288618021,0.272600035917053,0.122013695732311,0.190083705640783,0.470276504601332,0.349970470064414,0.152459839248687,0.0621072247498661,0.362028017963757,100289061,null,"non_coding"]
["ADAMTSL5",2.83498439265835,3.79513109741866,2.73327733959656,4.12872282506311,3.55372607314682,3.16415747713067,2.54705132412644,3.15438451450168,2.35233821339216,4.1738242975843,2.40580885987728,2.84262637969334,2.26939816530724,3.00312281943229,2.05062637615165,2.90520762954467,2.64306983373878,3.55930578536875,2.33784698631449,2.80879266382351,2.80193710194252,2.7764164616708,1.67736754411059,2.07960799910107,2.66871635812704,2.91142146281983,1.70882838635432,3.24850919801757,339366,"ADAMTS like 5","protein_coding",null,null,"GO:0001527,GO:0005515,GO:0005576,GO:0008201,GO:0030198,GO:0031012,GO:0050436","microfibril|protein binding|extracellular region|heparin binding|extracellular matrix organization|extracellular matrix|microfibril binding",null,null,"R-HSA-1643685,R-HSA-3781865,R-HSA-3906995,R-HSA-392499,R-HSA-5083635,R-HSA-5173105,R-HSA-5173214,R-HSA-5668914,R-HSA-597592","Disease|Diseases of glycosylation|Diseases associated with O-glycosylation of proteins|Metabolism of proteins|Defective B3GALTL causes PpS|O-linked glycosylation|O-glycosylation of TSR domain-containing proteins|Diseases of metabolism|Post-translational protein modification"]
["ADAP1",0.213783970863499,0.21258693597032,0.191584950828459,0.0838764288297927,0.132936807312684,0.0821266540567442,0.208524810307325,0.0476445216655332,0.0781955253843351,0.168464753496759,0.0822483266561583,0.0977656532699147,0.0277236355536884,0.0833796176385606,0.00903717713688375,0.0184272435091181,0.0653991985016474,0.0809209549869599,0.134716162669916,0.0280335273005556,0.0091718349022801,0.064657582093186,0.0287797968165569,0.0189873714907531,0.12524341394453,0.064633298830734,0.12224421309815,0.0182710607479906,11033,"ArfGAP with dual PH domains 1","protein_coding",null,null,"GO:0005096,GO:0005515,GO:0005547,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0007166,GO:0043087,GO:0043231,GO:0043533,GO:0046872,GO:1902936","GTPase activator activity|protein binding|phosphatidylinositol-3,4,5-trisphosphate binding|nucleus|cytoplasm|cytosol|plasma membrane|cell surface receptor signaling pathway|regulation of GTPase activity|intracellular membrane-bounded organelle|inositol 1,3,4,5 tetrakisphosphate binding|metal ion binding|phosphatidylinositol bisphosphate binding",null,null,"R-HSA-1236394,R-HSA-1251985,R-HSA-162582,R-HSA-9006934","Signaling by ERBB4|Nuclear signaling by ERBB4|Signal Transduction|Signaling by Receptor Tyrosine Kinases"]
["ADAP2",0.0454726977652549,0.0346016640486808,0.0341531169975032,0.0436109637077982,0.0444340061072619,0.0341609444224634,0.118791725827249,0.0624265399258653,0.201253227191093,0.148906523568004,0.136846218709961,0.201296973271132,0.0864882647615066,0.112716890511387,0.279109740035294,0.0689840398033654,0.0174876977678398,0.067318857140149,0.0756483067300297,0.148673535811921,0.0171677935350371,0.0432234752088148,0.233436129734295,0.0355404645852558,0.144264603044587,0.0086414483784681,0.105607426700177,0.0854991945258537,55803,"ArfGAP with dual PH domains 2","protein_coding",null,null,"GO:0005096,GO:0005515,GO:0005546,GO:0005547,GO:0005737,GO:0005740,GO:0005886,GO:0007507,GO:0030674,GO:0043087,GO:0043231,GO:0043325,GO:0043533,GO:0046872","GTPase activator activity|protein binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylinositol-3,4,5-trisphosphate binding|cytoplasm|mitochondrial envelope|plasma membrane|heart development|protein-macromolecule adaptor activity|regulation of GTPase activity|intracellular membrane-bounded organelle|phosphatidylinositol-3,4-bisphosphate binding|inositol 1,3,4,5 tetrakisphosphate binding|metal ion binding","WP3945,WP5366","TYROBP causal network in microglia|NF1 copy number variation syndrome "]
["ADAR",39.9960104100152,41.2523134095195,40.6182244896924,35.2311151974102,39.4737957763855,41.1278377543275,40.6297532283174,38.5789566324409,42.4501821042004,45.5013339187828,40.5171556639562,43.4858254515157,44.2883199675081,44.6480230091919,45.636779258255,45.5210825917085,36.4411411172183,39.7828542942064,31.6604811806689,39.1114153318598,38.1961025935922,36.5271446559431,32.6995131638064,36.6718111320072,39.0348590664399,34.0253432326952,32.1730049959504,34.5992013803882,103,"adenosine deaminase RNA specific","protein_coding","hsa04622,hsa04623,hsa05171,hsa05164,hsa05162","RIG-I-like receptor signaling pathway|Cytosolic DNA-sensing pathway|Coronavirus disease - COVID-19|Influenza A|Measles","GO:0001649,GO:0002244,GO:0002566,GO:0003677,GO:0003723,GO:0003725,GO:0003726,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0006382,GO:0006396,GO:0006397,GO:0008251,GO:0009615,GO:0016020,GO:0016553,GO:0030218,GO:0031054,GO:0035455,GO:0044387,GO:0044530,GO:0045070,GO:0045087,GO:0046872,GO:0051607,GO:0060216,GO:0060339,GO:0061484,GO:0070922,GO:0097284,GO:0098586,GO:1900369,GO:1903944","osteoblast differentiation|hematopoietic progenitor cell differentiation|somatic diversification of immune receptors via somatic mutation|DNA binding|RNA binding|double-stranded RNA binding|double-stranded RNA adenosine deaminase activity|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|adenosine to inosine editing|RNA processing|mRNA processing|tRNA-specific adenosine deaminase activity|response to virus|membrane|base conversion or substitution editing|erythrocyte differentiation|pre-miRNA processing|response to interferon-alpha|negative regulation of protein kinase activity by regulation of protein phosphorylation|supraspliceosomal complex|positive regulation of viral genome replication|innate immune response|metal ion binding|defense response to virus|definitive hemopoiesis|negative regulation of type I interferon-mediated signaling pathway|hematopoietic stem cell homeostasis|RISC complex assembly|hepatocyte apoptotic process|cellular response to virus|negative regulation of post-transcriptional gene silencing by regulatory ncRNA|negative regulation of hepatocyte apoptotic process","WP4630,WP4655,WP4705","Measles virus infection|Cytosolic DNA-sensing pathway|Pathways of nucleic acid metabolism and innate immune sensing","R-HSA-1280215,R-HSA-168256,R-HSA-75064,R-HSA-75072,R-HSA-75102,R-HSA-77042,R-HSA-8953854,R-HSA-909733,R-HSA-913531","Cytokine Signaling in Immune system|Immune System|mRNA Editing: A to I Conversion|mRNA Editing|C6 deamination of adenosine|Formation of editosomes by ADAR proteins|Metabolism of RNA|Interferon alpha/beta signaling|Interferon Signaling"]
["ADARB1",0.342635424307095,0.570727930838668,0.486440507533262,0.527374664253989,0.463832836370864,0.547763372777085,0.550466059024433,0.450714575304464,0.427023301119954,0.555368934079461,0.520281636117481,0.502786301643429,0.427569923775951,0.621452499024837,0.519164757698225,0.538809492437372,0.419411983630702,0.397445473623467,0.236344672588835,0.514318814363368,0.421204916607947,0.373349199180901,0.305255950898827,0.442517127593614,0.415921344631478,0.431969544537947,0.315388250682914,0.356685590615334,104,"adenosine deaminase RNA specific B1","protein_coding",null,null,"GO:0003723,GO:0003725,GO:0003726,GO:0003729,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0006382,GO:0006396,GO:0006397,GO:0007274,GO:0008251,GO:0008285,GO:0016553,GO:0021610,GO:0021618,GO:0021965,GO:0030336,GO:0035264,GO:0044387,GO:0045070,GO:0045087,GO:0045202,GO:0046872,GO:0050884,GO:0051607,GO:0051726,GO:0060384,GO:0060415,GO:0061744,GO:0097049","RNA binding|double-stranded RNA binding|double-stranded RNA adenosine deaminase activity|mRNA binding|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|adenosine to inosine editing|RNA processing|mRNA processing|neuromuscular synaptic transmission|tRNA-specific adenosine deaminase activity|negative regulation of cell population proliferation|base conversion or substitution editing|facial nerve morphogenesis|hypoglossal nerve morphogenesis|spinal cord ventral commissure morphogenesis|negative regulation of cell migration|multicellular organism growth|negative regulation of protein kinase activity by regulation of protein phosphorylation|positive regulation of viral genome replication|innate immune response|synapse|metal ion binding|neuromuscular process controlling posture|defense response to virus|regulation of cell cycle|innervation|muscle tissue morphogenesis|motor behavior|motor neuron apoptotic process",null,null,"R-HSA-75064,R-HSA-75072,R-HSA-75102,R-HSA-77042,R-HSA-8953854","mRNA Editing: A to I Conversion|mRNA Editing|C6 deamination of adenosine|Formation of editosomes by ADAR proteins|Metabolism of RNA"]
["ADAT1",5.37123168429595,4.65038308411978,3.95389027800047,3.72936650742623,4.79523817229547,4.30500521268462,3.5898127135839,3.72838518615684,3.91595064172896,4.29273570736564,3.06672791724086,3.9168018454219,3.73259828003931,3.17394941096482,3.51483828460968,3.17811345244597,4.01410378073218,4.05243732365774,3.24081583459798,4.22041671256568,4.27120915620556,3.98587679562851,3.7356082390819,3.95010047327024,4.35121344592871,3.51334143478027,3.54284675011468,3.50178273491854,23536,"adenosine deaminase tRNA specific 1","protein_coding",null,null,"GO:0003723,GO:0008033,GO:0008251,GO:0043829,GO:0046872","RNA binding|tRNA processing|tRNA-specific adenosine deaminase activity|tRNA-specific adenosine-37 deaminase activity|metal ion binding",null,null,"R-HSA-6782315,R-HSA-72306,R-HSA-8953854","tRNA modification in the nucleus and cytosol|tRNA processing|Metabolism of RNA"]
["ADAT2",0.738931338685392,0.845971365917465,0.814823512912022,0.855567815285714,0.976740243339629,0.756975472997768,0.66685355180297,0.67980069776413,0.718939731019422,0.525353363229899,0.669652306045195,0.673138742230015,0.618391093044772,0.561022705045315,0.507280030270758,0.695523742222,0.612268145712664,0.584258831145327,0.523998245859776,0.627887298970399,0.573170197794762,0.643636839927625,0.721529855542367,0.643161248318408,0.527467454881773,0.502971574937654,0.634444616463944,0.535535863893756,134637,"adenosine deaminase tRNA specific 2","protein_coding",null,null,"GO:0002100,GO:0005515,GO:0005654,GO:0008270,GO:0052717","tRNA wobble adenosine to inosine editing|protein binding|nucleoplasm|zinc ion binding|tRNA-specific adenosine-34 deaminase activity",null,null,"R-HSA-6782315,R-HSA-72306,R-HSA-8953854","tRNA modification in the nucleus and cytosol|tRNA processing|Metabolism of RNA"]
["ADAT3",1.50037720821553,1.81194567591507,2.18413348213301,2.27968335167202,1.69672877954949,1.59889883772456,1.28973873755299,1.83494874848292,1.81440270899996,2.38677716112159,2.63178642567816,1.57734701450151,1.63526104495414,2.2983248894517,1.67754649369328,1.47053782410101,1.83151644427083,2.23055286402176,2.3215214780782,2.04260800421084,1.73436587371033,1.69857715259615,1.98048438772698,1.28465776866705,1.53764954952402,2.22654294317407,1.77815431460217,3.05878581781761,113179,"secretory carrier membrane protein 4","protein_coding",null,null,"GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0008033,GO:0046872,GO:0052717","protein binding|nucleus|nucleoplasm|cytoplasm|tRNA processing|metal ion binding|tRNA-specific adenosine-34 deaminase activity",null,null,"R-HSA-6782315,R-HSA-72306,R-HSA-8953854","tRNA modification in the nucleus and cytosol|tRNA processing|Metabolism of RNA"]
["ADCK1",1.11044565812139,1.6933019653884,1.47277500841434,2.01726752057145,1.12526892955436,1.73242449488933,1.6828729189976,1.42305920077361,1.35335098949153,1.97489959246105,2.06651808936173,1.41866742199168,1.31863311145887,1.93250013243804,1.64468350974114,1.58209211773969,1.18060255693443,1.32645146538442,1.14033062193741,1.2260248493743,0.953822851624913,1.3012489390109,0.887443978819873,0.792130956311921,0.873747309743129,0.965800516112434,0.773226826005308,1.28145924405654,57143,"aarF domain containing kinase 1","protein_coding",null,null,"GO:0004674,GO:0005524,GO:0005576,GO:0005743,GO:0007005,GO:0010637,GO:0016310,GO:0055088,GO:1903852","protein serine/threonine kinase activity|ATP binding|extracellular region|mitochondrial inner membrane|mitochondrion organization|negative regulation of mitochondrial fusion|phosphorylation|lipid homeostasis|positive regulation of cristae formation"]
["ADCK2",5.09788393147482,5.61968943782411,6.22093567848813,6.12867461764355,5.00148361163319,6.41500420021013,5.44531817447461,5.92433157732202,5.85000274281557,5.40387093546859,6.06759106091202,5.63456048345608,5.06264389249854,5.20247638944796,5.71400627749299,5.44627419269492,6.06499709914088,6.2354091426063,6.22837725410578,5.96750733925716,5.74105910244388,5.86947161890367,5.5795498680099,4.80011299825956,5.99990884751363,6.66646310796999,5.39964182300206,6.99121838343253,90956,"aarF domain containing kinase 2","protein_coding",null,null,"GO:0004674,GO:0005515,GO:0005524,GO:0016020,GO:0016310","protein serine/threonine kinase activity|protein binding|ATP binding|membrane|phosphorylation"]
["ADCK5",2.73746817072003,3.09303290148999,3.44580871010934,3.15214178228186,2.75160888065469,2.87352981752358,2.74111193849596,3.02630851859424,2.51675409073552,4.48378494305746,3.35331877896259,3.09619270783546,3.15879086620094,2.88412338606045,2.58636878120674,3.02536958261829,3.02585811163966,3.30726746244318,3.15044696811819,3.05158060827445,2.99519142525507,2.79266146409304,2.63363064348355,2.80219091874998,2.82635213210906,3.27206821880429,2.66587026804729,3.42591843648756,203054,"aarF domain containing kinase 5","protein_coding",null,null,"GO:0004674,GO:0005515,GO:0016020,GO:0016310","protein serine/threonine kinase activity|protein binding|membrane|phosphorylation"]
["ADCY1",0.0164643244680061,0.0156603042052664,0.0231859456666512,0.0177640260783207,0.0301654590247192,0.0115956297833464,0.00384026651126637,0.0363259467980364,0.0248413178442677,0.0336966663502493,0.00774187265720579,0.0186350381702297,0.0704584196298046,0.0294313456671969,0.0114837972412805,0.00585400521006571,0.0237441759889496,0.0114253946726638,0.0171187647845326,0.0356229980447738,0.0174823660230817,0.0078249736154483,0.00406347820884252,0.0120638956746104,0.0224442811768291,0.0078220348125758,0.00995764024848977,0.0270871474732388,107,"adenylate cyclase 1","protein_coding","hsa00230,hsa04015,hsa04371,hsa04020,hsa04072,hsa04024,hsa04022,hsa04114,hsa04540,hsa04611,hsa04062,hsa04911,hsa04923,hsa04912,hsa04913,hsa04915,hsa04914,hsa04921,hsa04926,hsa04935,hsa04918,hsa04928,hsa04916,hsa04925,hsa04927,hsa04261,hsa04270,hsa04970,hsa04971,hsa04972,hsa04976,hsa04724,hsa04727,hsa04725,hsa04720,hsa04723,hsa04750,hsa04211,hsa04213,hsa04713,hsa04714,hsa05200,hsa05207,hsa05166,hsa05163,hsa05146,hsa05142,hsa05032,hsa05414,hsa04934,hsa01522","Purine metabolism|Rap1 signaling pathway|Apelin signaling pathway|Calcium signaling pathway|Phospholipase D signaling pathway|cAMP signaling pathway|cGMP-PKG signaling pathway|Oocyte meiosis|Gap junction|Platelet activation|Chemokine signaling pathway|Insulin secretion|Regulation of lipolysis in adipocytes|GnRH signaling pathway|Ovarian steroidogenesis|Estrogen signaling pathway|Progesterone-mediated oocyte maturation|Oxytocin signaling pathway|Relaxin signaling pathway|Growth hormone synthesis, secretion and action|Thyroid hormone synthesis|Parathyroid hormone synthesis, secretion and action|Melanogenesis|Aldosterone synthesis and secretion|Cortisol synthesis and secretion|Adrenergic signaling in cardiomyocytes|Vascular smooth muscle contraction|Salivary secretion|Gastric acid secretion|Pancreatic secretion|Bile secretion|Glutamatergic synapse|GABAergic synapse|Cholinergic synapse|Long-term potentiation|Retrograde endocannabinoid signaling|Inflammatory mediator regulation of TRP channels|Longevity regulating pathway|Longevity regulating pathway - multiple species|Circadian entrainment|Thermogenesis|Pathways in cancer|Chemical carcinogenesis - receptor activation|Human T-cell leukemia virus 1 infection|Human cytomegalovirus infection|Amoebiasis|Chagas disease|Morphine addiction|Dilated cardiomyopathy|Cushing syndrome|Endocrine resistance","GO:0004016,GO:0005516,GO:0005524,GO:0005737,GO:0005886,GO:0006171,GO:0007189,GO:0007409,GO:0007616,GO:0007623,GO:0008294,GO:0009410,GO:0019933,GO:0032793,GO:0042752,GO:0045121,GO:0046872,GO:0070062,GO:0071277,GO:0098685,GO:0098686,GO:0098793,GO:0098839,GO:0098978,GO:0099171,GO:0150076,GO:1900273,GO:1904322","adenylate cyclase activity|calmodulin binding|ATP binding|cytoplasm|plasma membrane|cAMP biosynthetic process|adenylate cyclase-activating G protein-coupled receptor signaling pathway|axonogenesis|long-term memory|circadian rhythm|calcium- and calmodulin-responsive adenylate cyclase activity|response to xenobiotic stimulus|cAMP-mediated signaling|positive regulation of CREB transcription factor activity|regulation of circadian rhythm|membrane raft|metal ion binding|extracellular exosome|cellular response to calcium ion|Schaffer collateral - CA1 synapse|hippocampal mossy fiber to CA3 synapse|presynapse|postsynaptic density membrane|glutamatergic synapse|presynaptic modulation of chemical synaptic transmission|neuroinflammatory response|positive regulation of long-term synaptic potentiation|cellular response to forskolin","WP5083,WP35,WP4321,WP289,WP4589,WP2636,WP4222,WP3869,WP3929,WP3594,WP3676,WP4535,WP5093,WP536","Neuroinflammation and glutamatergic signaling|G protein signaling pathways|Thermogenesis|Myometrial relaxation and contraction pathways|Major receptors targeted by epinephrine and norepinephrine|Common pathways underlying drug addiction|Phosphodiesterases in neuronal function|Cannabinoid receptor signaling|Chemokine signaling pathway|Circadian rhythm genes|BDNF-TrkB signaling|Envelope proteins and their potential roles in EDMD physiopathology|Opioid receptor pathways|Calcium regulation in cardiac cells","R-HSA-111885,R-HSA-111885,R-HSA-111931,R-HSA-111933,R-HSA-111996,R-HSA-111997,R-HSA-112040,R-HSA-112040,R-HSA-112043,R-HSA-112314,R-HSA-112314,R-HSA-112315,R-HSA-112315,R-HSA-112316,R-HSA-112316,R-HSA-1430728,R-HSA-1489509,R-HSA-162582,R-HSA-162582,R-HSA-163359,R-HSA-163615,R-HSA-163685,R-HSA-1643685,R-HSA-1643685,R-HSA-164378,R-HSA-170660,R-HSA-170670,R-HSA-170670,R-HSA-372790,R-HSA-372790,R-HSA-382551,R-HSA-388396,R-HSA-388396,R-HSA-418555,R-HSA-418555,R-HSA-418594,R-HSA-418594,R-HSA-418597,R-HSA-418597,R-HSA-432040,R-HSA-438064,R-HSA-442720,R-HSA-442755,R-HSA-445717,R-HSA-5358351,R-HSA-5610787,R-HSA-5663205,R-HSA-5663205,R-HSA-9006925,R-HSA-9634597,R-HSA-9634597,R-HSA-9658195,R-HSA-9658195,R-HSA-9660821,R-HSA-9660821,R-HSA-9662851,R-HSA-9662851,R-HSA-9664323,R-HSA-9664433,R-HSA-9664433,R-HSA-977443,R-HSA-977443,R-HSA-977444,R-HSA-977444,R-HSA-9824443,R-HSA-9824443,R-HSA-991365,R-HSA-991365","Opioid Signalling|Opioid Signalling|PKA-mediated phosphorylation of CREB|Calmodulin induced events|Ca-dependent events|CaM pathway|G-protein mediated events|G-protein mediated events|PLC beta mediated events|Neurotransmitter receptors and postsynaptic signal transmission|Neurotransmitter receptors and postsynaptic signal transmission|Transmission across Chemical Synapses|Transmission across Chemical Synapses|Neuronal System|Neuronal System|Metabolism|DAG and IP3 signaling|Signal Transduction|Signal Transduction|Glucagon signaling in metabolic regulation|PKA activation|Integration of energy metabolism|Disease|Disease|PKA activation in glucagon signalling|Adenylate cyclase activating pathway|Adenylate cyclase inhibitory pathway|Adenylate cyclase inhibitory pathway|Signaling by GPCR|Signaling by GPCR|Transport of small molecules|GPCR downstream signalling|GPCR downstream signalling|G alpha (s) signalling events|G alpha (s) signalling events|G alpha (i) signalling events|G alpha (i) signalling events|G alpha (z) signalling events|G alpha (z) signalling events|Vasopressin regulates renal water homeostasis via Aquaporins|Post NMDA receptor activation events|CREB1 phosphorylation through the activation of Adenylate Cyclase|Activation of NMDA receptors and postsynaptic events|Aquaporin-mediated transport|Signaling by Hedgehog|Hedgehog 'off' state|Infectious disease|Infectious disease|Intracellular signaling by second messengers|GPER1 signaling|GPER1 signaling|Leishmania infection|Leishmania infection|ADORA2B mediated anti-inflammatory cytokines production|ADORA2B mediated anti-inflammatory cytokines production|Anti-inflammatory response favouring Leishmania parasite infection|Anti-inflammatory response favouring Leishmania parasite infection|FCGR3A-mediated IL10 synthesis|Leishmania parasite growth and survival|Leishmania parasite growth and survival|GABA receptor activation|GABA receptor activation|GABA B receptor activation|GABA B receptor activation|Parasitic Infection Pathways|Parasitic Infection Pathways|Activation of GABAB receptors|Activation of GABAB receptors"]
["ADCY10",3.0994843319815E-3,0.0324293622698399,0.00581981365876736,0.00297258586707862,0,0.0203740161802136,0.0115671635654977,0.0121573786915202,0.0311766108163943,0.00895560205051572,0.00582977164907907,0.00311833876245537,0,0.0177298730849233,0.011530012361833,0.0117551278588694,0.00893989930732618,0.00573568737965395,0.00286460952241268,0.00894158959776259,0.0117018144274692,0,0,0.0151405566618803,0.0122916029499872,0.00294506760880527,0.0089979421852169,0.00582774778830931,55811,"adenylate cyclase 10","protein_coding","hsa00230,hsa04371,hsa04024,hsa04935,hsa04713,hsa04714","Purine metabolism|Apelin signaling pathway|cAMP signaling pathway|Growth hormone synthesis, secretion and action|Circadian entrainment|Thermogenesis","GO:0000287,GO:0003351,GO:0004016,GO:0005524,GO:0005576,GO:0005634,GO:0005737,GO:0005739,GO:0005829,GO:0006007,GO:0006171,GO:0007286,GO:0010613,GO:0010666,GO:0010800,GO:0010917,GO:0015630,GO:0016324,GO:0030145,GO:0030425,GO:0031514,GO:0035556,GO:0043025,GO:0045178,GO:0045773,GO:0045778,GO:0045819,GO:0048471,GO:0051117,GO:0051901,GO:0060306,GO:0071241,GO:0071890,GO:0090724,GO:0097450,GO:0106028,GO:0106135,GO:1901524,GO:1903378,GO:1903427,GO:1903428,GO:1903955,GO:1905461,GO:1990138,GO:1990535,GO:1990544,GO:2001171","magnesium ion binding|epithelial cilium movement involved in extracellular fluid movement|adenylate cyclase activity|ATP binding|extracellular region|nucleus|cytoplasm|mitochondrion|cytosol|glucose catabolic process|cAMP biosynthetic process|spermatid development|positive regulation of cardiac muscle hypertrophy|positive regulation of cardiac muscle cell apoptotic process|positive regulation of peptidyl-threonine phosphorylation|negative regulation of mitochondrial membrane potential|microtubule cytoskeleton|apical plasma membrane|manganese ion binding|dendrite|motile cilium|intracellular signal transduction|neuronal cell body|basal part of cell|positive regulation of axon extension|positive regulation of ossification|positive regulation of glycogen catabolic process|perinuclear region of cytoplasm|ATPase binding|positive regulation of mitochondrial depolarization|regulation of membrane repolarization|cellular response to inorganic substance|bicarbonate binding|central region of growth cone|astrocyte end-foot|neuron projection retraction|negative regulation of cardiac muscle cell contraction|regulation of mitophagy|positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway|negative regulation of reactive oxygen species biosynthetic process|positive regulation of reactive oxygen species biosynthetic process|positive regulation of protein targeting to mitochondrion|positive regulation of vascular associated smooth muscle cell apoptotic process|neuron projection extension|neuron projection maintenance|mitochondrial ATP transmembrane transport|positive regulation of ATP biosynthetic process","WP4321,WP4589,WP4222,WP2197,WP4535","Thermogenesis|Major receptors targeted by epinephrine and norepinephrine|Phosphodiesterases in neuronal function|Endothelin pathways|Envelope proteins and their potential roles in EDMD physiopathology","R-HSA-162582,R-HSA-5358351,R-HSA-5610787","Signal Transduction|Signaling by Hedgehog|Hedgehog 'off' state"]
["ADCY2",0.0567926280351247,0.03086812106555,0.0190424828405943,0.0155621244761371,0.0356755920817853,0.0304749553854571,0.022708718178134,0.0198895264259125,0.0530452790897271,0.0976760359083712,0.122080419038773,0.0979510328381918,0.119591989756904,0.0773497397640221,0.0490441959232959,0.0692331920915943,0.0312015266720103,0.033780997612314,0.018746056445766,0.0117027847602319,0.0306307539731226,0.0269917430739651,0.0120143199953542,0.0634112487769441,0.0241309415024919,0.0578177268482606,0.0157020523069639,0.0266958207377338,108,"adenylate cyclase 2","protein_coding","hsa00230,hsa04015,hsa04371,hsa04020,hsa04072,hsa04024,hsa04022,hsa04114,hsa04540,hsa04611,hsa04062,hsa04911,hsa04922,hsa04923,hsa04912,hsa04913,hsa04915,hsa04914,hsa04921,hsa04926,hsa04935,hsa04918,hsa04928,hsa04916,hsa04925,hsa04927,hsa04261,hsa04270,hsa04970,hsa04971,hsa04972,hsa04976,hsa04724,hsa04727,hsa04725,hsa04723,hsa04750,hsa04211,hsa04213,hsa04713,hsa04714,hsa05200,hsa05207,hsa05166,hsa05163,hsa05032,hsa05414,hsa04934,hsa01522","Purine metabolism|Rap1 signaling pathway|Apelin signaling pathway|Calcium signaling pathway|Phospholipase D signaling pathway|cAMP signaling pathway|cGMP-PKG signaling pathway|Oocyte meiosis|Gap junction|Platelet activation|Chemokine signaling pathway|Insulin secretion|Glucagon signaling pathway|Regulation of lipolysis in adipocytes|GnRH signaling pathway|Ovarian steroidogenesis|Estrogen signaling pathway|Progesterone-mediated oocyte maturation|Oxytocin signaling pathway|Relaxin signaling pathway|Growth hormone synthesis, secretion and action|Thyroid hormone synthesis|Parathyroid hormone synthesis, secretion and action|Melanogenesis|Aldosterone synthesis and secretion|Cortisol synthesis and secretion|Adrenergic signaling in cardiomyocytes|Vascular smooth muscle contraction|Salivary secretion|Gastric acid secretion|Pancreatic secretion|Bile secretion|Glutamatergic synapse|GABAergic synapse|Cholinergic synapse|Retrograde endocannabinoid signaling|Inflammatory mediator regulation of TRP channels|Longevity regulating pathway|Longevity regulating pathway - multiple species|Circadian entrainment|Thermogenesis|Pathways in cancer|Chemical carcinogenesis - receptor activation|Human T-cell leukemia virus 1 infection|Human cytomegalovirus infection|Morphine addiction|Dilated cardiomyopathy|Cushing syndrome|Endocrine resistance","GO:0000287,GO:0004016,GO:0005524,GO:0005737,GO:0005886,GO:0006171,GO:0007188,GO:0007189,GO:0007193,GO:0008179,GO:0016020,GO:0019933,GO:0030145,GO:0030425,GO:0045121,GO:1904322","magnesium ion binding|adenylate cyclase activity|ATP binding|cytoplasm|plasma membrane|cAMP biosynthetic process|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|adenylate cyclase-activating G protein-coupled receptor signaling pathway|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway|adenylate cyclase binding|membrane|cAMP-mediated signaling|manganese ion binding|dendrite|membrane raft|cellular response to forskolin","WP35,WP4321,WP4941,WP289,WP4589,WP2032,WP4222,WP3929,WP4535,WP1602,WP536","G protein signaling pathways|Thermogenesis|GPR143 in melanocytes and retinal pigment epithelium cells|Myometrial relaxation and contraction pathways|Major receptors targeted by epinephrine and norepinephrine|Thyroid stimulating hormone (TSH) signaling pathway|Phosphodiesterases in neuronal function|Chemokine signaling pathway|Envelope proteins and their potential roles in EDMD physiopathology|Nicotine effect on dopaminergic neurons|Calcium regulation in cardiac cells","R-HSA-111885,R-HSA-111885,R-HSA-111931,R-HSA-111933,R-HSA-111996,R-HSA-111997,R-HSA-112040,R-HSA-112040,R-HSA-112043,R-HSA-112314,R-HSA-112314,R-HSA-112315,R-HSA-112315,R-HSA-112316,R-HSA-112316,R-HSA-1430728,R-HSA-1489509,R-HSA-162582,R-HSA-162582,R-HSA-163359,R-HSA-163615,R-HSA-163685,R-HSA-1643685,R-HSA-1643685,R-HSA-164378,R-HSA-170660,R-HSA-170670,R-HSA-170670,R-HSA-372790,R-HSA-372790,R-HSA-382551,R-HSA-388396,R-HSA-388396,R-HSA-418555,R-HSA-418555,R-HSA-418594,R-HSA-418594,R-HSA-418597,R-HSA-418597,R-HSA-432040,R-HSA-445717,R-HSA-5358351,R-HSA-5610787,R-HSA-5663205,R-HSA-5663205,R-HSA-9006925,R-HSA-9634597,R-HSA-9634597,R-HSA-9658195,R-HSA-9658195,R-HSA-9660821,R-HSA-9660821,R-HSA-9662851,R-HSA-9662851,R-HSA-9664323,R-HSA-9664433,R-HSA-9664433,R-HSA-977443,R-HSA-977443,R-HSA-977444,R-HSA-977444,R-HSA-9824443,R-HSA-9824443,R-HSA-991365,R-HSA-991365","Opioid Signalling|Opioid Signalling|PKA-mediated phosphorylation of CREB|Calmodulin induced events|Ca-dependent events|CaM pathway|G-protein mediated events|G-protein mediated events|PLC beta mediated events|Neurotransmitter receptors and postsynaptic signal transmission|Neurotransmitter receptors and postsynaptic signal transmission|Transmission across Chemical Synapses|Transmission across Chemical Synapses|Neuronal System|Neuronal System|Metabolism|DAG and IP3 signaling|Signal Transduction|Signal Transduction|Glucagon signaling in metabolic regulation|PKA activation|Integration of energy metabolism|Disease|Disease|PKA activation in glucagon signalling|Adenylate cyclase activating pathway|Adenylate cyclase inhibitory pathway|Adenylate cyclase inhibitory pathway|Signaling by GPCR|Signaling by GPCR|Transport of small molecules|GPCR downstream signalling|GPCR downstream signalling|G alpha (s) signalling events|G alpha (s) signalling events|G alpha (i) signalling events|G alpha (i) signalling events|G alpha (z) signalling events|G alpha (z) signalling events|Vasopressin regulates renal water homeostasis via Aquaporins|Aquaporin-mediated transport|Signaling by Hedgehog|Hedgehog 'off' state|Infectious disease|Infectious disease|Intracellular signaling by second messengers|GPER1 signaling|GPER1 signaling|Leishmania infection|Leishmania infection|ADORA2B mediated anti-inflammatory cytokines production|ADORA2B mediated anti-inflammatory cytokines production|Anti-inflammatory response favouring Leishmania parasite infection|Anti-inflammatory response favouring Leishmania parasite infection|FCGR3A-mediated IL10 synthesis|Leishmania parasite growth and survival|Leishmania parasite growth and survival|GABA receptor activation|GABA receptor activation|GABA B receptor activation|GABA B receptor activation|Parasitic Infection Pathways|Parasitic Infection Pathways|Activation of GABAB receptors|Activation of GABAB receptors"]
["ADCY3",15.9168157879817,16.9652647452442,14.7769319162113,15.2745931293482,14.9376533168003,16.7953964168601,14.1017636350178,15.2701448752601,14.7378613140831,19.4444613826755,16.9683939292917,15.2956497642035,14.9074059769699,16.2774138480833,15.2144944406657,15.7168742312197,13.5569729018448,14.8092390226442,11.8904350134982,13.961826057978,13.2300025951978,13.8617093108483,10.1889308566772,12.2132791700736,13.7260315555066,12.8089647525948,9.75866997904689,12.6594131824756,109,"adenylate cyclase 3","protein_coding","hsa00230,hsa04015,hsa04371,hsa04020,hsa04072,hsa04024,hsa04022,hsa04114,hsa04540,hsa04611,hsa04062,hsa04911,hsa04923,hsa04912,hsa04913,hsa04915,hsa04914,hsa04921,hsa04926,hsa04935,hsa04918,hsa04928,hsa04916,hsa04925,hsa04927,hsa04261,hsa04270,hsa04970,hsa04971,hsa04972,hsa04976,hsa04962,hsa04724,hsa04727,hsa04725,hsa04723,hsa04740,hsa04750,hsa04211,hsa04213,hsa04713,hsa04714,hsa05200,hsa05207,hsa05166,hsa05163,hsa05110,hsa05032,hsa05414,hsa04934,hsa01522","Purine metabolism|Rap1 signaling pathway|Apelin signaling pathway|Calcium signaling pathway|Phospholipase D signaling pathway|cAMP signaling pathway|cGMP-PKG signaling pathway|Oocyte meiosis|Gap junction|Platelet activation|Chemokine signaling pathway|Insulin secretion|Regulation of lipolysis in adipocytes|GnRH signaling pathway|Ovarian steroidogenesis|Estrogen signaling pathway|Progesterone-mediated oocyte maturation|Oxytocin signaling pathway|Relaxin signaling pathway|Growth hormone synthesis, secretion and action|Thyroid hormone synthesis|Parathyroid hormone synthesis, secretion and action|Melanogenesis|Aldosterone synthesis and secretion|Cortisol synthesis and secretion|Adrenergic signaling in cardiomyocytes|Vascular smooth muscle contraction|Salivary secretion|Gastric acid secretion|Pancreatic secretion|Bile secretion|Vasopressin-regulated water reabsorption|Glutamatergic synapse|GABAergic synapse|Cholinergic synapse|Retrograde endocannabinoid signaling|Olfactory transduction|Inflammatory mediator regulation of TRP channels|Longevity regulating pathway|Longevity regulating pathway - multiple species|Circadian entrainment|Thermogenesis|Pathways in cancer|Chemical carcinogenesis - receptor activation|Human T-cell leukemia virus 1 infection|Human cytomegalovirus infection|Vibrio cholerae infection|Morphine addiction|Dilated cardiomyopathy|Cushing syndrome|Endocrine resistance","GO:0004016,GO:0005516,GO:0005524,GO:0005737,GO:0005794,GO:0005886,GO:0005929,GO:0006171,GO:0007165,GO:0007189,GO:0007338,GO:0007340,GO:0007608,GO:0008355,GO:0016020,GO:0030317,GO:0035556,GO:0046872,GO:0060170,GO:1904322","adenylate cyclase activity|calmodulin binding|ATP binding|cytoplasm|Golgi apparatus|plasma membrane|cilium|cAMP biosynthetic process|signal transduction|adenylate cyclase-activating G protein-coupled receptor signaling pathway|single fertilization|acrosome reaction|sensory perception of smell|olfactory learning|membrane|flagellated sperm motility|intracellular signal transduction|metal ion binding|ciliary membrane|cellular response to forskolin","WP5083,WP35,WP4321,WP289,WP4589,WP2032,WP4746,WP4222,WP5122,WP3929,WP5085,WP4535,WP536,WP5321","Neuroinflammation and glutamatergic signaling|G protein signaling pathways|Thermogenesis|Myometrial relaxation and contraction pathways|Major receptors targeted by epinephrine and norepinephrine|Thyroid stimulating hormone (TSH) signaling pathway|Thyroid hormones production and peripheral downstream signaling effects|Phosphodiesterases in neuronal function|Prostaglandin and leukotriene metabolism in senescence |Chemokine signaling pathway|Vasopressin-regulated water reabsorption|Envelope proteins and their potential roles in EDMD physiopathology|Calcium regulation in cardiac cells|Prostaglandin and leukotriene metabolism in senescence ","R-HSA-111885,R-HSA-111885,R-HSA-111931,R-HSA-111933,R-HSA-111996,R-HSA-111997,R-HSA-112040,R-HSA-112040,R-HSA-112043,R-HSA-112314,R-HSA-112314,R-HSA-112315,R-HSA-112315,R-HSA-112316,R-HSA-112316,R-HSA-1430728,R-HSA-1489509,R-HSA-162582,R-HSA-162582,R-HSA-163359,R-HSA-163615,R-HSA-163685,R-HSA-1643685,R-HSA-1643685,R-HSA-164378,R-HSA-170660,R-HSA-170670,R-HSA-170670,R-HSA-372790,R-HSA-372790,R-HSA-381753,R-HSA-382551,R-HSA-388396,R-HSA-388396,R-HSA-418555,R-HSA-418555,R-HSA-418594,R-HSA-418594,R-HSA-418597,R-HSA-418597,R-HSA-432040,R-HSA-445717,R-HSA-5358351,R-HSA-5610787,R-HSA-5663205,R-HSA-5663205,R-HSA-9006925,R-HSA-9634597,R-HSA-9634597,R-HSA-9658195,R-HSA-9658195,R-HSA-9660821,R-HSA-9660821,R-HSA-9662851,R-HSA-9662851,R-HSA-9664323,R-HSA-9664433,R-HSA-9664433,R-HSA-9709957,R-HSA-977443,R-HSA-977443,R-HSA-977444,R-HSA-977444,R-HSA-9824443,R-HSA-9824443,R-HSA-991365,R-HSA-991365","Opioid Signalling|Opioid Signalling|PKA-mediated phosphorylation of CREB|Calmodulin induced events|Ca-dependent events|CaM pathway|G-protein mediated events|G-protein mediated events|PLC beta mediated events|Neurotransmitter receptors and postsynaptic signal transmission|Neurotransmitter receptors and postsynaptic signal transmission|Transmission across Chemical Synapses|Transmission across Chemical Synapses|Neuronal System|Neuronal System|Metabolism|DAG and IP3 signaling|Signal Transduction|Signal Transduction|Glucagon signaling in metabolic regulation|PKA activation|Integration of energy metabolism|Disease|Disease|PKA activation in glucagon signalling|Adenylate cyclase activating pathway|Adenylate cyclase inhibitory pathway|Adenylate cyclase inhibitory pathway|Signaling by GPCR|Signaling by GPCR|Olfactory Signaling Pathway|Transport of small molecules|GPCR downstream signalling|GPCR downstream signalling|G alpha (s) signalling events|G alpha (s) signalling events|G alpha (i) signalling events|G alpha (i) signalling events|G alpha (z) signalling events|G alpha (z) signalling events|Vasopressin regulates renal water homeostasis via Aquaporins|Aquaporin-mediated transport|Signaling by Hedgehog|Hedgehog 'off' state|Infectious disease|Infectious disease|Intracellular signaling by second messengers|GPER1 signaling|GPER1 signaling|Leishmania infection|Leishmania infection|ADORA2B mediated anti-inflammatory cytokines production|ADORA2B mediated anti-inflammatory cytokines production|Anti-inflammatory response favouring Leishmania parasite infection|Anti-inflammatory response favouring Leishmania parasite infection|FCGR3A-mediated IL10 synthesis|Leishmania parasite growth and survival|Leishmania parasite growth and survival|Sensory Perception|GABA receptor activation|GABA receptor activation|GABA B receptor activation|GABA B receptor activation|Parasitic Infection Pathways|Parasitic Infection Pathways|Activation of GABAB receptors|Activation of GABAB receptors"]
["ADCY4",0,0.131309118097406,0.0341070885379378,0.125430303813393,0.0638987356828743,0.0750527919103771,0.0677895023781225,0.0213745395849362,0.0146168724673952,0.0209937657771793,0.0478316264453214,0.0219300745690628,0.0276389452024911,0.0969790605154579,0.0540574218387396,0.0137782138798635,0.0279426071072114,0.0470596916423117,0.00671523154081486,0.0279478902899339,0.0480050377715566,0.0483450492524253,0.014345940048361,0.0425910796620074,0.0288140352711696,0.0828461013275885,0,0.0887993251609217,196883,"adenylate cyclase 4","protein_coding","hsa00230,hsa04015,hsa04371,hsa04020,hsa04072,hsa04024,hsa04022,hsa04114,hsa04540,hsa04611,hsa04062,hsa04911,hsa04923,hsa04912,hsa04913,hsa04915,hsa04914,hsa04921,hsa04926,hsa04935,hsa04918,hsa04928,hsa04916,hsa04925,hsa04927,hsa04261,hsa04270,hsa04970,hsa04971,hsa04972,hsa04976,hsa04724,hsa04727,hsa04725,hsa04723,hsa04742,hsa04750,hsa04211,hsa04213,hsa04713,hsa04714,hsa05200,hsa05207,hsa05166,hsa05163,hsa05032,hsa05414,hsa04934,hsa01522","Purine metabolism|Rap1 signaling pathway|Apelin signaling pathway|Calcium signaling pathway|Phospholipase D signaling pathway|cAMP signaling pathway|cGMP-PKG signaling pathway|Oocyte meiosis|Gap junction|Platelet activation|Chemokine signaling pathway|Insulin secretion|Regulation of lipolysis in adipocytes|GnRH signaling pathway|Ovarian steroidogenesis|Estrogen signaling pathway|Progesterone-mediated oocyte maturation|Oxytocin signaling pathway|Relaxin signaling pathway|Growth hormone synthesis, secretion and action|Thyroid hormone synthesis|Parathyroid hormone synthesis, secretion and action|Melanogenesis|Aldosterone synthesis and secretion|Cortisol synthesis and secretion|Adrenergic signaling in cardiomyocytes|Vascular smooth muscle contraction|Salivary secretion|Gastric acid secretion|Pancreatic secretion|Bile secretion|Glutamatergic synapse|GABAergic synapse|Cholinergic synapse|Retrograde endocannabinoid signaling|Taste transduction|Inflammatory mediator regulation of TRP channels|Longevity regulating pathway|Longevity regulating pathway - multiple species|Circadian entrainment|Thermogenesis|Pathways in cancer|Chemical carcinogenesis - receptor activation|Human T-cell leukemia virus 1 infection|Human cytomegalovirus infection|Morphine addiction|Dilated cardiomyopathy|Cushing syndrome|Endocrine resistance","GO:0004016,GO:0005080,GO:0005515,GO:0005524,GO:0005737,GO:0005886,GO:0006171,GO:0007188,GO:0007189,GO:0007193,GO:0016020,GO:0030425,GO:0035556,GO:0046872","adenylate cyclase activity|protein kinase C binding|protein binding|ATP binding|cytoplasm|plasma membrane|cAMP biosynthetic process|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|adenylate cyclase-activating G protein-coupled receptor signaling pathway|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway|membrane|dendrite|intracellular signal transduction|metal ion binding","WP35,WP4321,WP4941,WP289,WP4589,WP4222,WP3929,WP4535,WP536","G protein signaling pathways|Thermogenesis|GPR143 in melanocytes and retinal pigment epithelium cells|Myometrial relaxation and contraction pathways|Major receptors targeted by epinephrine and norepinephrine|Phosphodiesterases in neuronal function|Chemokine signaling pathway|Envelope proteins and their potential roles in EDMD physiopathology|Calcium regulation in cardiac cells","R-HSA-111885,R-HSA-111885,R-HSA-111931,R-HSA-111933,R-HSA-111996,R-HSA-111997,R-HSA-112040,R-HSA-112040,R-HSA-112043,R-HSA-112314,R-HSA-112314,R-HSA-112315,R-HSA-112315,R-HSA-112316,R-HSA-112316,R-HSA-1430728,R-HSA-1489509,R-HSA-162582,R-HSA-162582,R-HSA-163359,R-HSA-163615,R-HSA-163685,R-HSA-1643685,R-HSA-1643685,R-HSA-164378,R-HSA-170660,R-HSA-170670,R-HSA-170670,R-HSA-372790,R-HSA-372790,R-HSA-382551,R-HSA-388396,R-HSA-388396,R-HSA-418555,R-HSA-418555,R-HSA-418594,R-HSA-418594,R-HSA-418597,R-HSA-418597,R-HSA-432040,R-HSA-445717,R-HSA-5358351,R-HSA-5610787,R-HSA-5663205,R-HSA-5663205,R-HSA-9006925,R-HSA-9634597,R-HSA-9634597,R-HSA-9658195,R-HSA-9658195,R-HSA-9660821,R-HSA-9660821,R-HSA-9662851,R-HSA-9662851,R-HSA-9664323,R-HSA-9664433,R-HSA-9664433,R-HSA-977443,R-HSA-977443,R-HSA-977444,R-HSA-977444,R-HSA-9824443,R-HSA-9824443,R-HSA-991365,R-HSA-991365","Opioid Signalling|Opioid Signalling|PKA-mediated phosphorylation of CREB|Calmodulin induced events|Ca-dependent events|CaM pathway|G-protein mediated events|G-protein mediated events|PLC beta mediated events|Neurotransmitter receptors and postsynaptic signal transmission|Neurotransmitter receptors and postsynaptic signal transmission|Transmission across Chemical Synapses|Transmission across Chemical Synapses|Neuronal System|Neuronal System|Metabolism|DAG and IP3 signaling|Signal Transduction|Signal Transduction|Glucagon signaling in metabolic regulation|PKA activation|Integration of energy metabolism|Disease|Disease|PKA activation in glucagon signalling|Adenylate cyclase activating pathway|Adenylate cyclase inhibitory pathway|Adenylate cyclase inhibitory pathway|Signaling by GPCR|Signaling by GPCR|Transport of small molecules|GPCR downstream signalling|GPCR downstream signalling|G alpha (s) signalling events|G alpha (s) signalling events|G alpha (i) signalling events|G alpha (i) signalling events|G alpha (z) signalling events|G alpha (z) signalling events|Vasopressin regulates renal water homeostasis via Aquaporins|Aquaporin-mediated transport|Signaling by Hedgehog|Hedgehog 'off' state|Infectious disease|Infectious disease|Intracellular signaling by second messengers|GPER1 signaling|GPER1 signaling|Leishmania infection|Leishmania infection|ADORA2B mediated anti-inflammatory cytokines production|ADORA2B mediated anti-inflammatory cytokines production|Anti-inflammatory response favouring Leishmania parasite infection|Anti-inflammatory response favouring Leishmania parasite infection|FCGR3A-mediated IL10 synthesis|Leishmania parasite growth and survival|Leishmania parasite growth and survival|GABA receptor activation|GABA receptor activation|GABA B receptor activation|GABA B receptor activation|Parasitic Infection Pathways|Parasitic Infection Pathways|Activation of GABAB receptors|Activation of GABAB receptors"]
["ADCY5",0.0747658806940754,0.0681516422491238,0.0146235176789263,0.0268893116345596,0.0700139850767192,0.0497313552397748,0.023251963834308,0.0183287973789699,0.0470027130943341,0.126015970699953,0.0439456177326136,0.081489078659879,0.0829519712133012,0.0712801138192895,0.127475059819655,0.100426666982895,0.0269560745206803,0.0317066915838064,0.0115167035786077,0.050926656667807,0.0117613174709002,0.0266503969645289,0.00307543265800412,0.0273915819159911,0.0555934726513553,0.0473606896914909,0.0301456539869915,0.0322155985013398,111,"adenylate cyclase 5","protein_coding","hsa00230,hsa04015,hsa04371,hsa04072,hsa04024,hsa04022,hsa04114,hsa04540,hsa04611,hsa04062,hsa04911,hsa04923,hsa04912,hsa04913,hsa04915,hsa04914,hsa04921,hsa04926,hsa04935,hsa04918,hsa04928,hsa04916,hsa04924,hsa04925,hsa04927,hsa04261,hsa04270,hsa04970,hsa04971,hsa04972,hsa04976,hsa04724,hsa04727,hsa04725,hsa04728,hsa04726,hsa04723,hsa04750,hsa04211,hsa04213,hsa04713,hsa04714,hsa05200,hsa05207,hsa05166,hsa05163,hsa05012,hsa05030,hsa05031,hsa05032,hsa05034,hsa05414,hsa04934,hsa01522","Purine metabolism|Rap1 signaling pathway|Apelin signaling pathway|Phospholipase D signaling pathway|cAMP signaling pathway|cGMP-PKG signaling pathway|Oocyte meiosis|Gap junction|Platelet activation|Chemokine signaling pathway|Insulin secretion|Regulation of lipolysis in adipocytes|GnRH signaling pathway|Ovarian steroidogenesis|Estrogen signaling pathway|Progesterone-mediated oocyte maturation|Oxytocin signaling pathway|Relaxin signaling pathway|Growth hormone synthesis, secretion and action|Thyroid hormone synthesis|Parathyroid hormone synthesis, secretion and action|Melanogenesis|Renin secretion|Aldosterone synthesis and secretion|Cortisol synthesis and secretion|Adrenergic signaling in cardiomyocytes|Vascular smooth muscle contraction|Salivary secretion|Gastric acid secretion|Pancreatic secretion|Bile secretion|Glutamatergic synapse|GABAergic synapse|Cholinergic synapse|Dopaminergic synapse|Serotonergic synapse|Retrograde endocannabinoid signaling|Inflammatory mediator regulation of TRP channels|Longevity regulating pathway|Longevity regulating pathway - multiple species|Circadian entrainment|Thermogenesis|Pathways in cancer|Chemical carcinogenesis - receptor activation|Human T-cell leukemia virus 1 infection|Human cytomegalovirus infection|Parkinson disease|Cocaine addiction|Amphetamine addiction|Morphine addiction|Alcoholism|Dilated cardiomyopathy|Cushing syndrome|Endocrine resistance","GO:0001973,GO:0004016,GO:0005524,GO:0005886,GO:0005929,GO:0006171,GO:0007189,GO:0007191,GO:0007193,GO:0007195,GO:0007204,GO:0007626,GO:0008179,GO:0016020,GO:0035556,GO:0046872,GO:0050885,GO:0061178,GO:0097110,GO:1904322","G protein-coupled adenosine receptor signaling pathway|adenylate cyclase activity|ATP binding|plasma membrane|cilium|cAMP biosynthetic process|adenylate cyclase-activating G protein-coupled receptor signaling pathway|adenylate cyclase-activating dopamine receptor signaling pathway|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway|adenylate cyclase-inhibiting dopamine receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|locomotory behavior|adenylate cyclase binding|membrane|intracellular signal transduction|metal ion binding|neuromuscular process controlling balance|regulation of insulin secretion involved in cellular response to glucose stimulus|scaffold protein binding|cellular response to forskolin","WP35,WP4321,WP289,WP4589,WP4222,WP3929,WP4535,WP536","G protein signaling pathways|Thermogenesis|Myometrial relaxation and contraction pathways|Major receptors targeted by epinephrine and norepinephrine|Phosphodiesterases in neuronal function|Chemokine signaling pathway|Envelope proteins and their potential roles in EDMD physiopathology|Calcium regulation in cardiac cells","R-HSA-111885,R-HSA-111885,R-HSA-111931,R-HSA-111933,R-HSA-111996,R-HSA-111997,R-HSA-112040,R-HSA-112040,R-HSA-112043,R-HSA-112314,R-HSA-112314,R-HSA-112315,R-HSA-112315,R-HSA-112316,R-HSA-112316,R-HSA-1430728,R-HSA-1489509,R-HSA-162582,R-HSA-162582,R-HSA-163359,R-HSA-163615,R-HSA-163685,R-HSA-1643685,R-HSA-1643685,R-HSA-164378,R-HSA-170660,R-HSA-170670,R-HSA-170670,R-HSA-372790,R-HSA-372790,R-HSA-381676,R-HSA-382551,R-HSA-388396,R-HSA-388396,R-HSA-400042,R-HSA-418555,R-HSA-418555,R-HSA-418594,R-HSA-418594,R-HSA-418597,R-HSA-418597,R-HSA-422356,R-HSA-432040,R-HSA-445717,R-HSA-5358351,R-HSA-5610787,R-HSA-5663205,R-HSA-5663205,R-HSA-9006925,R-HSA-9634597,R-HSA-9634597,R-HSA-9658195,R-HSA-9658195,R-HSA-9660821,R-HSA-9660821,R-HSA-9662851,R-HSA-9662851,R-HSA-9664323,R-HSA-9664433,R-HSA-9664433,R-HSA-977443,R-HSA-977443,R-HSA-977444,R-HSA-977444,R-HSA-9824443,R-HSA-9824443,R-HSA-991365,R-HSA-991365","Opioid Signalling|Opioid Signalling|PKA-mediated phosphorylation of CREB|Calmodulin induced events|Ca-dependent events|CaM pathway|G-protein mediated events|G-protein mediated events|PLC beta mediated events|Neurotransmitter receptors and postsynaptic signal transmission|Neurotransmitter receptors and postsynaptic signal transmission|Transmission across Chemical Synapses|Transmission across Chemical Synapses|Neuronal System|Neuronal System|Metabolism|DAG and IP3 signaling|Signal Transduction|Signal Transduction|Glucagon signaling in metabolic regulation|PKA activation|Integration of energy metabolism|Disease|Disease|PKA activation in glucagon signalling|Adenylate cyclase activating pathway|Adenylate cyclase inhibitory pathway|Adenylate cyclase inhibitory pathway|Signaling by GPCR|Signaling by GPCR|Glucagon-like Peptide-1 (GLP1) regulates insulin secretion|Transport of small molecules|GPCR downstream signalling|GPCR downstream signalling|Adrenaline,noradrenaline inhibits insulin secretion|G alpha (s) signalling events|G alpha (s) signalling events|G alpha (i) signalling events|G alpha (i) signalling events|G alpha (z) signalling events|G alpha (z) signalling events|Regulation of insulin secretion|Vasopressin regulates renal water homeostasis via Aquaporins|Aquaporin-mediated transport|Signaling by Hedgehog|Hedgehog 'off' state|Infectious disease|Infectious disease|Intracellular signaling by second messengers|GPER1 signaling|GPER1 signaling|Leishmania infection|Leishmania infection|ADORA2B mediated anti-inflammatory cytokines production|ADORA2B mediated anti-inflammatory cytokines production|Anti-inflammatory response favouring Leishmania parasite infection|Anti-inflammatory response favouring Leishmania parasite infection|FCGR3A-mediated IL10 synthesis|Leishmania parasite growth and survival|Leishmania parasite growth and survival|GABA receptor activation|GABA receptor activation|GABA B receptor activation|GABA B receptor activation|Parasitic Infection Pathways|Parasitic Infection Pathways|Activation of GABAB receptors|Activation of GABAB receptors"]
["ADCY6",11.8415652351011,10.9884998828882,10.753516476189,10.6070221909706,12.4744469107761,11.311334357787,10.0523515397602,11.181858653414,13.7913352483408,17.0615883590023,13.1884055072626,13.9516308467612,14.0312776689601,15.4306879127817,12.4065480781154,14.4212174622976,9.81641298047957,10.9377142846978,7.66472853361145,10.6909313864382,9.45077617901312,9.80201816906885,6.80140637835601,8.96223326332918,10.8605134399513,9.26223800102881,6.84769154082372,9.12898541326086,112,"adenylate cyclase 6","protein_coding","hsa00230,hsa04015,hsa04371,hsa04072,hsa04024,hsa04022,hsa04114,hsa04540,hsa04611,hsa04062,hsa04911,hsa04923,hsa04912,hsa04913,hsa04915,hsa04914,hsa04921,hsa04926,hsa04935,hsa04918,hsa04928,hsa04916,hsa04924,hsa04925,hsa04927,hsa04261,hsa04270,hsa04970,hsa04971,hsa04972,hsa04976,hsa04962,hsa04961,hsa04724,hsa04727,hsa04725,hsa04723,hsa04742,hsa04750,hsa04211,hsa04213,hsa04713,hsa04714,hsa05200,hsa05207,hsa05166,hsa05163,hsa05032,hsa05414,hsa04934,hsa01522","Purine metabolism|Rap1 signaling pathway|Apelin signaling pathway|Phospholipase D signaling pathway|cAMP signaling pathway|cGMP-PKG signaling pathway|Oocyte meiosis|Gap junction|Platelet activation|Chemokine signaling pathway|Insulin secretion|Regulation of lipolysis in adipocytes|GnRH signaling pathway|Ovarian steroidogenesis|Estrogen signaling pathway|Progesterone-mediated oocyte maturation|Oxytocin signaling pathway|Relaxin signaling pathway|Growth hormone synthesis, secretion and action|Thyroid hormone synthesis|Parathyroid hormone synthesis, secretion and action|Melanogenesis|Renin secretion|Aldosterone synthesis and secretion|Cortisol synthesis and secretion|Adrenergic signaling in cardiomyocytes|Vascular smooth muscle contraction|Salivary secretion|Gastric acid secretion|Pancreatic secretion|Bile secretion|Vasopressin-regulated water reabsorption|Endocrine and other factor-regulated calcium reabsorption|Glutamatergic synapse|GABAergic synapse|Cholinergic synapse|Retrograde endocannabinoid signaling|Taste transduction|Inflammatory mediator regulation of TRP channels|Longevity regulating pathway|Longevity regulating pathway - multiple species|Circadian entrainment|Thermogenesis|Pathways in cancer|Chemical carcinogenesis - receptor activation|Human T-cell leukemia virus 1 infection|Human cytomegalovirus infection|Morphine addiction|Dilated cardiomyopathy|Cushing syndrome|Endocrine resistance","GO:0003091,GO:0004016,GO:0005080,GO:0005515,GO:0005524,GO:0005886,GO:0005929,GO:0006171,GO:0007189,GO:0007193,GO:0007212,GO:0010977,GO:0016020,GO:0019901,GO:0032420,GO:0035556,GO:0035811,GO:0046872,GO:0071380,GO:0071870,GO:0097746,GO:1904117,GO:1904322","renal water homeostasis|adenylate cyclase activity|protein kinase C binding|protein binding|ATP binding|plasma membrane|cilium|cAMP biosynthetic process|adenylate cyclase-activating G protein-coupled receptor signaling pathway|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway|dopamine receptor signaling pathway|negative regulation of neuron projection development|membrane|protein kinase binding|stereocilium|intracellular signal transduction|negative regulation of urine volume|metal ion binding|cellular response to prostaglandin E stimulus|cellular response to catecholamine stimulus|blood vessel diameter maintenance|cellular response to vasopressin|cellular response to forskolin","WP35,WP4321,WP289,WP4589,WP4222,WP3929,WP5085,WP4535,WP536,WP4803","G protein signaling pathways|Thermogenesis|Myometrial relaxation and contraction pathways|Major receptors targeted by epinephrine and norepinephrine|Phosphodiesterases in neuronal function|Chemokine signaling pathway|Vasopressin-regulated water reabsorption|Envelope proteins and their potential roles in EDMD physiopathology|Calcium regulation in cardiac cells|Ciliopathies","R-HSA-111885,R-HSA-111885,R-HSA-111931,R-HSA-111933,R-HSA-111996,R-HSA-111997,R-HSA-112040,R-HSA-112040,R-HSA-112043,R-HSA-112314,R-HSA-112314,R-HSA-112315,R-HSA-112315,R-HSA-112316,R-HSA-112316,R-HSA-1430728,R-HSA-1489509,R-HSA-162582,R-HSA-162582,R-HSA-163359,R-HSA-163615,R-HSA-163685,R-HSA-1643685,R-HSA-1643685,R-HSA-164378,R-HSA-170660,R-HSA-170670,R-HSA-170670,R-HSA-372790,R-HSA-372790,R-HSA-381676,R-HSA-382551,R-HSA-388396,R-HSA-388396,R-HSA-400042,R-HSA-418555,R-HSA-418555,R-HSA-418594,R-HSA-418594,R-HSA-418597,R-HSA-418597,R-HSA-422356,R-HSA-432040,R-HSA-445717,R-HSA-5358351,R-HSA-5610787,R-HSA-5663205,R-HSA-5663205,R-HSA-9006925,R-HSA-9634597,R-HSA-9634597,R-HSA-9658195,R-HSA-9658195,R-HSA-9660821,R-HSA-9660821,R-HSA-9662851,R-HSA-9662851,R-HSA-9664323,R-HSA-9664433,R-HSA-9664433,R-HSA-977443,R-HSA-977443,R-HSA-977444,R-HSA-977444,R-HSA-9824443,R-HSA-9824443,R-HSA-991365,R-HSA-991365","Opioid Signalling|Opioid Signalling|PKA-mediated phosphorylation of CREB|Calmodulin induced events|Ca-dependent events|CaM pathway|G-protein mediated events|G-protein mediated events|PLC beta mediated events|Neurotransmitter receptors and postsynaptic signal transmission|Neurotransmitter receptors and postsynaptic signal transmission|Transmission across Chemical Synapses|Transmission across Chemical Synapses|Neuronal System|Neuronal System|Metabolism|DAG and IP3 signaling|Signal Transduction|Signal Transduction|Glucagon signaling in metabolic regulation|PKA activation|Integration of energy metabolism|Disease|Disease|PKA activation in glucagon signalling|Adenylate cyclase activating pathway|Adenylate cyclase inhibitory pathway|Adenylate cyclase inhibitory pathway|Signaling by GPCR|Signaling by GPCR|Glucagon-like Peptide-1 (GLP1) regulates insulin secretion|Transport of small molecules|GPCR downstream signalling|GPCR downstream signalling|Adrenaline,noradrenaline inhibits insulin secretion|G alpha (s) signalling events|G alpha (s) signalling events|G alpha (i) signalling events|G alpha (i) signalling events|G alpha (z) signalling events|G alpha (z) signalling events|Regulation of insulin secretion|Vasopressin regulates renal water homeostasis via Aquaporins|Aquaporin-mediated transport|Signaling by Hedgehog|Hedgehog 'off' state|Infectious disease|Infectious disease|Intracellular signaling by second messengers|GPER1 signaling|GPER1 signaling|Leishmania infection|Leishmania infection|ADORA2B mediated anti-inflammatory cytokines production|ADORA2B mediated anti-inflammatory cytokines production|Anti-inflammatory response favouring Leishmania parasite infection|Anti-inflammatory response favouring Leishmania parasite infection|FCGR3A-mediated IL10 synthesis|Leishmania parasite growth and survival|Leishmania parasite growth and survival|GABA receptor activation|GABA receptor activation|GABA B receptor activation|GABA B receptor activation|Parasitic Infection Pathways|Parasitic Infection Pathways|Activation of GABAB receptors|Activation of GABAB receptors"]
["ADCY6-DT",0,0.138843861336132,0,0,0,0.0456918047239086,0.0453969411232553,0.0477133224188408,0,0.093726679943845,0.0915189964477269,0.146860246662857,0.0925455656148396,0.04638890078808,0.362009088486866,0.553615597411124,0.0935623396820887,0.0900420092795133,0.0449702328816302,0,0.045925397146074,0,0.144106780449691,0.190147900777433,0.0964802083538262,0.092466617306063,0.282509397779174,0.0914872247561842,100506125,"ADCY6 divergent transcript","non_coding"]
["ADCY7",5.25907370047535,5.35982417462467,4.51016677479623,4.03424717865527,4.77546848842855,4.61524789970204,4.61500025364861,3.98515509347898,4.72072195162119,4.76788391381397,3.27862908633498,3.55922663565244,4.376636304813,4.30839299527202,4.54497574595987,4.62620925708046,3.59532381780416,3.4600479387921,3.15259024840821,4.27715136614196,3.62666362131183,3.32510605926986,3.68782479998325,3.6804728439968,3.91145664428476,3.00425559924101,3.04044587633373,2.81990702189621,113,"adenylate cyclase 7","protein_coding","hsa00230,hsa04015,hsa04371,hsa04020,hsa04072,hsa04024,hsa04022,hsa04114,hsa04540,hsa04611,hsa04062,hsa04911,hsa04923,hsa04912,hsa04913,hsa04915,hsa04914,hsa04921,hsa04926,hsa04935,hsa04918,hsa04928,hsa04916,hsa04925,hsa04927,hsa04261,hsa04270,hsa04970,hsa04971,hsa04972,hsa04976,hsa04724,hsa04727,hsa04725,hsa04723,hsa04750,hsa04211,hsa04213,hsa04713,hsa04714,hsa05200,hsa05207,hsa05166,hsa05163,hsa05032,hsa05414,hsa04934,hsa01522","Purine metabolism|Rap1 signaling pathway|Apelin signaling pathway|Calcium signaling pathway|Phospholipase D signaling pathway|cAMP signaling pathway|cGMP-PKG signaling pathway|Oocyte meiosis|Gap junction|Platelet activation|Chemokine signaling pathway|Insulin secretion|Regulation of lipolysis in adipocytes|GnRH signaling pathway|Ovarian steroidogenesis|Estrogen signaling pathway|Progesterone-mediated oocyte maturation|Oxytocin signaling pathway|Relaxin signaling pathway|Growth hormone synthesis, secretion and action|Thyroid hormone synthesis|Parathyroid hormone synthesis, secretion and action|Melanogenesis|Aldosterone synthesis and secretion|Cortisol synthesis and secretion|Adrenergic signaling in cardiomyocytes|Vascular smooth muscle contraction|Salivary secretion|Gastric acid secretion|Pancreatic secretion|Bile secretion|Glutamatergic synapse|GABAergic synapse|Cholinergic synapse|Retrograde endocannabinoid signaling|Inflammatory mediator regulation of TRP channels|Longevity regulating pathway|Longevity regulating pathway - multiple species|Circadian entrainment|Thermogenesis|Pathways in cancer|Chemical carcinogenesis - receptor activation|Human T-cell leukemia virus 1 infection|Human cytomegalovirus infection|Morphine addiction|Dilated cardiomyopathy|Cushing syndrome|Endocrine resistance","GO:0002819,GO:0004016,GO:0005524,GO:0005886,GO:0006171,GO:0007189,GO:0007193,GO:0016020,GO:0035556,GO:0046872,GO:0060135,GO:0071285,GO:0071361,GO:1900016","regulation of adaptive immune response|adenylate cyclase activity|ATP binding|plasma membrane|cAMP biosynthetic process|adenylate cyclase-activating G protein-coupled receptor signaling pathway|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway|membrane|intracellular signal transduction|metal ion binding|maternal process involved in female pregnancy|cellular response to lithium ion|cellular response to ethanol|negative regulation of cytokine production involved in inflammatory response","WP35,WP4321,WP289,WP4589,WP4222,WP3869,WP3929,WP4535,WP536","G protein signaling pathways|Thermogenesis|Myometrial relaxation and contraction pathways|Major receptors targeted by epinephrine and norepinephrine|Phosphodiesterases in neuronal function|Cannabinoid receptor signaling|Chemokine signaling pathway|Envelope proteins and their potential roles in EDMD physiopathology|Calcium regulation in cardiac cells","R-HSA-111885,R-HSA-111885,R-HSA-111931,R-HSA-111933,R-HSA-111996,R-HSA-111997,R-HSA-112040,R-HSA-112040,R-HSA-112043,R-HSA-112314,R-HSA-112314,R-HSA-112315,R-HSA-112315,R-HSA-112316,R-HSA-112316,R-HSA-1430728,R-HSA-1489509,R-HSA-162582,R-HSA-162582,R-HSA-163359,R-HSA-163615,R-HSA-163685,R-HSA-1643685,R-HSA-1643685,R-HSA-164378,R-HSA-170660,R-HSA-170670,R-HSA-170670,R-HSA-372790,R-HSA-372790,R-HSA-382551,R-HSA-388396,R-HSA-388396,R-HSA-418555,R-HSA-418555,R-HSA-418594,R-HSA-418594,R-HSA-418597,R-HSA-418597,R-HSA-432040,R-HSA-445717,R-HSA-5358351,R-HSA-5610787,R-HSA-5663205,R-HSA-5663205,R-HSA-9006925,R-HSA-9634597,R-HSA-9634597,R-HSA-9658195,R-HSA-9658195,R-HSA-9660821,R-HSA-9660821,R-HSA-9662851,R-HSA-9662851,R-HSA-9664323,R-HSA-9664433,R-HSA-9664433,R-HSA-977443,R-HSA-977443,R-HSA-977444,R-HSA-977444,R-HSA-9824443,R-HSA-9824443,R-HSA-991365,R-HSA-991365","Opioid Signalling|Opioid Signalling|PKA-mediated phosphorylation of CREB|Calmodulin induced events|Ca-dependent events|CaM pathway|G-protein mediated events|G-protein mediated events|PLC beta mediated events|Neurotransmitter receptors and postsynaptic signal transmission|Neurotransmitter receptors and postsynaptic signal transmission|Transmission across Chemical Synapses|Transmission across Chemical Synapses|Neuronal System|Neuronal System|Metabolism|DAG and IP3 signaling|Signal Transduction|Signal Transduction|Glucagon signaling in metabolic regulation|PKA activation|Integration of energy metabolism|Disease|Disease|PKA activation in glucagon signalling|Adenylate cyclase activating pathway|Adenylate cyclase inhibitory pathway|Adenylate cyclase inhibitory pathway|Signaling by GPCR|Signaling by GPCR|Transport of small molecules|GPCR downstream signalling|GPCR downstream signalling|G alpha (s) signalling events|G alpha (s) signalling events|G alpha (i) signalling events|G alpha (i) signalling events|G alpha (z) signalling events|G alpha (z) signalling events|Vasopressin regulates renal water homeostasis via Aquaporins|Aquaporin-mediated transport|Signaling by Hedgehog|Hedgehog 'off' state|Infectious disease|Infectious disease|Intracellular signaling by second messengers|GPER1 signaling|GPER1 signaling|Leishmania infection|Leishmania infection|ADORA2B mediated anti-inflammatory cytokines production|ADORA2B mediated anti-inflammatory cytokines production|Anti-inflammatory response favouring Leishmania parasite infection|Anti-inflammatory response favouring Leishmania parasite infection|FCGR3A-mediated IL10 synthesis|Leishmania parasite growth and survival|Leishmania parasite growth and survival|GABA receptor activation|GABA receptor activation|GABA B receptor activation|GABA B receptor activation|Parasitic Infection Pathways|Parasitic Infection Pathways|Activation of GABAB receptors|Activation of GABAB receptors"]
["ADCY8",0,4.8698638290736E-3,0,0,0.00500293994689171,0,0.00955362027817035,0,0,0.00493110927719754,0.00481495954720234,0.0103020673189266,0.0146069069374989,0,0.00476146806794216,0,0,0,0,0,0.0096648319160209,0,0.0101089150198327,0,0,0,0.00495442248716881,0,114,"adenylate cyclase 8","protein_coding","hsa00230,hsa04015,hsa04371,hsa04020,hsa04072,hsa04024,hsa04022,hsa04114,hsa04540,hsa04611,hsa04062,hsa04911,hsa04923,hsa04912,hsa04913,hsa04915,hsa04914,hsa04921,hsa04926,hsa04935,hsa04918,hsa04928,hsa04916,hsa04925,hsa04927,hsa04261,hsa04270,hsa04970,hsa04971,hsa04972,hsa04976,hsa04724,hsa04727,hsa04725,hsa04720,hsa04723,hsa04742,hsa04750,hsa04211,hsa04213,hsa04713,hsa04714,hsa05200,hsa05207,hsa05166,hsa05163,hsa05032,hsa05414,hsa04934,hsa01522","Purine metabolism|Rap1 signaling pathway|Apelin signaling pathway|Calcium signaling pathway|Phospholipase D signaling pathway|cAMP signaling pathway|cGMP-PKG signaling pathway|Oocyte meiosis|Gap junction|Platelet activation|Chemokine signaling pathway|Insulin secretion|Regulation of lipolysis in adipocytes|GnRH signaling pathway|Ovarian steroidogenesis|Estrogen signaling pathway|Progesterone-mediated oocyte maturation|Oxytocin signaling pathway|Relaxin signaling pathway|Growth hormone synthesis, secretion and action|Thyroid hormone synthesis|Parathyroid hormone synthesis, secretion and action|Melanogenesis|Aldosterone synthesis and secretion|Cortisol synthesis and secretion|Adrenergic signaling in cardiomyocytes|Vascular smooth muscle contraction|Salivary secretion|Gastric acid secretion|Pancreatic secretion|Bile secretion|Glutamatergic synapse|GABAergic synapse|Cholinergic synapse|Long-term potentiation|Retrograde endocannabinoid signaling|Taste transduction|Inflammatory mediator regulation of TRP channels|Longevity regulating pathway|Longevity regulating pathway - multiple species|Circadian entrainment|Thermogenesis|Pathways in cancer|Chemical carcinogenesis - receptor activation|Human T-cell leukemia virus 1 infection|Human cytomegalovirus infection|Morphine addiction|Dilated cardiomyopathy|Cushing syndrome|Endocrine resistance","GO:0003779,GO:0004016,GO:0005516,GO:0005524,GO:0005886,GO:0005901,GO:0005905,GO:0006171,GO:0007165,GO:0007189,GO:0007204,GO:0007611,GO:0007613,GO:0007616,GO:0007626,GO:0008294,GO:0010255,GO:0014069,GO:0015629,GO:0016020,GO:0016323,GO:0016324,GO:0030424,GO:0030425,GO:0030665,GO:0031915,GO:0032793,GO:0032809,GO:0034199,GO:0035556,GO:0035774,GO:0038003,GO:0042593,GO:0042734,GO:0042803,GO:0044853,GO:0045121,GO:0046872,GO:0046982,GO:0046983,GO:0048786,GO:0050796,GO:0051259,GO:0051260,GO:0051480,GO:0051721,GO:0060076,GO:0071277,GO:0071315,GO:0071333,GO:0071377,GO:0080135,GO:0098685,GO:0098686,GO:0098978,GO:0150076,GO:1900273,GO:1900454,GO:1904322","actin binding|adenylate cyclase activity|calmodulin binding|ATP binding|plasma membrane|caveola|clathrin-coated pit|cAMP biosynthetic process|signal transduction|adenylate cyclase-activating G protein-coupled receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|learning or memory|memory|long-term memory|locomotory behavior|calcium- and calmodulin-responsive adenylate cyclase activity|glucose mediated signaling pathway|postsynaptic density|actin cytoskeleton|membrane|basolateral plasma membrane|apical plasma membrane|axon|dendrite|clathrin-coated vesicle membrane|positive regulation of synaptic plasticity|positive regulation of CREB transcription factor activity|neuronal cell body membrane|activation of protein kinase A activity|intracellular signal transduction|positive regulation of insulin secretion involved in cellular response to glucose stimulus|G protein-coupled opioid receptor signaling pathway|glucose homeostasis|presynaptic membrane|protein homodimerization activity|plasma membrane raft|membrane raft|metal ion binding|protein heterodimerization activity|protein dimerization activity|presynaptic active zone|regulation of insulin secretion|protein complex oligomerization|protein homooligomerization|regulation of cytosolic calcium ion concentration|protein phosphatase 2A binding|excitatory synapse|cellular response to calcium ion|cellular response to morphine|cellular response to glucose stimulus|cellular response to glucagon stimulus|regulation of cellular response to stress|Schaffer collateral - CA1 synapse|hippocampal mossy fiber to CA3 synapse|glutamatergic synapse|neuroinflammatory response|positive regulation of long-term synaptic potentiation|positive regulation of long-term synaptic depression|cellular response to forskolin","WP5083,WP35,WP4321,WP289,WP4589,WP2636,WP4746,WP4222,WP3929,WP4535,WP5093,WP536","Neuroinflammation and glutamatergic signaling|G protein signaling pathways|Thermogenesis|Myometrial relaxation and contraction pathways|Major receptors targeted by epinephrine and norepinephrine|Common pathways underlying drug addiction|Thyroid hormones production and peripheral downstream signaling effects|Phosphodiesterases in neuronal function|Chemokine signaling pathway|Envelope proteins and their potential roles in EDMD physiopathology|Opioid receptor pathways|Calcium regulation in cardiac cells","R-HSA-111885,R-HSA-111885,R-HSA-111931,R-HSA-111933,R-HSA-111996,R-HSA-111997,R-HSA-112040,R-HSA-112040,R-HSA-112043,R-HSA-112314,R-HSA-112314,R-HSA-112315,R-HSA-112315,R-HSA-112316,R-HSA-112316,R-HSA-1430728,R-HSA-1489509,R-HSA-162582,R-HSA-162582,R-HSA-163359,R-HSA-163615,R-HSA-163685,R-HSA-1643685,R-HSA-1643685,R-HSA-164378,R-HSA-170660,R-HSA-170670,R-HSA-170670,R-HSA-372790,R-HSA-372790,R-HSA-381676,R-HSA-382551,R-HSA-388396,R-HSA-388396,R-HSA-418555,R-HSA-418555,R-HSA-418594,R-HSA-418594,R-HSA-418597,R-HSA-418597,R-HSA-422356,R-HSA-432040,R-HSA-438064,R-HSA-442720,R-HSA-442755,R-HSA-445717,R-HSA-5358351,R-HSA-5610787,R-HSA-5663205,R-HSA-5663205,R-HSA-9006925,R-HSA-9634597,R-HSA-9634597,R-HSA-9658195,R-HSA-9658195,R-HSA-9660821,R-HSA-9660821,R-HSA-9662851,R-HSA-9662851,R-HSA-9664323,R-HSA-9664433,R-HSA-9664433,R-HSA-977443,R-HSA-977443,R-HSA-977444,R-HSA-977444,R-HSA-9824443,R-HSA-9824443,R-HSA-991365,R-HSA-991365","Opioid Signalling|Opioid Signalling|PKA-mediated phosphorylation of CREB|Calmodulin induced events|Ca-dependent events|CaM pathway|G-protein mediated events|G-protein mediated events|PLC beta mediated events|Neurotransmitter receptors and postsynaptic signal transmission|Neurotransmitter receptors and postsynaptic signal transmission|Transmission across Chemical Synapses|Transmission across Chemical Synapses|Neuronal System|Neuronal System|Metabolism|DAG and IP3 signaling|Signal Transduction|Signal Transduction|Glucagon signaling in metabolic regulation|PKA activation|Integration of energy metabolism|Disease|Disease|PKA activation in glucagon signalling|Adenylate cyclase activating pathway|Adenylate cyclase inhibitory pathway|Adenylate cyclase inhibitory pathway|Signaling by GPCR|Signaling by GPCR|Glucagon-like Peptide-1 (GLP1) regulates insulin secretion|Transport of small molecules|GPCR downstream signalling|GPCR downstream signalling|G alpha (s) signalling events|G alpha (s) signalling events|G alpha (i) signalling events|G alpha (i) signalling events|G alpha (z) signalling events|G alpha (z) signalling events|Regulation of insulin secretion|Vasopressin regulates renal water homeostasis via Aquaporins|Post NMDA receptor activation events|CREB1 phosphorylation through the activation of Adenylate Cyclase|Activation of NMDA receptors and postsynaptic events|Aquaporin-mediated transport|Signaling by Hedgehog|Hedgehog 'off' state|Infectious disease|Infectious disease|Intracellular signaling by second messengers|GPER1 signaling|GPER1 signaling|Leishmania infection|Leishmania infection|ADORA2B mediated anti-inflammatory cytokines production|ADORA2B mediated anti-inflammatory cytokines production|Anti-inflammatory response favouring Leishmania parasite infection|Anti-inflammatory response favouring Leishmania parasite infection|FCGR3A-mediated IL10 synthesis|Leishmania parasite growth and survival|Leishmania parasite growth and survival|GABA receptor activation|GABA receptor activation|GABA B receptor activation|GABA B receptor activation|Parasitic Infection Pathways|Parasitic Infection Pathways|Activation of GABAB receptors|Activation of GABAB receptors"]
["ADCY9",13.4368497884994,14.9186343457162,11.9363701170218,12.145995680215,13.6653126927844,14.7720088512352,12.2439113260633,12.6518064214188,11.7095788603028,14.4927245843424,10.1316134713224,10.9782484963447,10.4712582231953,10.1388063229966,10.5101872155378,11.1065782252509,8.87269298213056,8.90227385855142,6.09796798381655,9.40442059590014,9.35525138567795,8.1665662419681,5.53935618250354,7.66170081991365,9.77768494299761,7.37004341072385,5.18059578653102,7.1709651605237,115,"adenylate cyclase 9","protein_coding","hsa00230,hsa04015,hsa04371,hsa04020,hsa04072,hsa04024,hsa04022,hsa04114,hsa04540,hsa04611,hsa04062,hsa04911,hsa04923,hsa04912,hsa04913,hsa04915,hsa04914,hsa04921,hsa04926,hsa04935,hsa04918,hsa04928,hsa04916,hsa04925,hsa04927,hsa04261,hsa04270,hsa04970,hsa04971,hsa04972,hsa04976,hsa04962,hsa04961,hsa04724,hsa04727,hsa04725,hsa04723,hsa04750,hsa04211,hsa04213,hsa04713,hsa04714,hsa05200,hsa05207,hsa05166,hsa05163,hsa05110,hsa05032,hsa05414,hsa04934,hsa01522","Purine metabolism|Rap1 signaling pathway|Apelin signaling pathway|Calcium signaling pathway|Phospholipase D signaling pathway|cAMP signaling pathway|cGMP-PKG signaling pathway|Oocyte meiosis|Gap junction|Platelet activation|Chemokine signaling pathway|Insulin secretion|Regulation of lipolysis in adipocytes|GnRH signaling pathway|Ovarian steroidogenesis|Estrogen signaling pathway|Progesterone-mediated oocyte maturation|Oxytocin signaling pathway|Relaxin signaling pathway|Growth hormone synthesis, secretion and action|Thyroid hormone synthesis|Parathyroid hormone synthesis, secretion and action|Melanogenesis|Aldosterone synthesis and secretion|Cortisol synthesis and secretion|Adrenergic signaling in cardiomyocytes|Vascular smooth muscle contraction|Salivary secretion|Gastric acid secretion|Pancreatic secretion|Bile secretion|Vasopressin-regulated water reabsorption|Endocrine and other factor-regulated calcium reabsorption|Glutamatergic synapse|GABAergic synapse|Cholinergic synapse|Retrograde endocannabinoid signaling|Inflammatory mediator regulation of TRP channels|Longevity regulating pathway|Longevity regulating pathway - multiple species|Circadian entrainment|Thermogenesis|Pathways in cancer|Chemical carcinogenesis - receptor activation|Human T-cell leukemia virus 1 infection|Human cytomegalovirus infection|Vibrio cholerae infection|Morphine addiction|Dilated cardiomyopathy|Cushing syndrome|Endocrine resistance","GO:0001701,GO:0004016,GO:0005524,GO:0005829,GO:0005886,GO:0006171,GO:0007165,GO:0007189,GO:0016020,GO:0030424,GO:0030425,GO:0035556,GO:0046872,GO:0071880","in utero embryonic development|adenylate cyclase activity|ATP binding|cytosol|plasma membrane|cAMP biosynthetic process|signal transduction|adenylate cyclase-activating G protein-coupled receptor signaling pathway|membrane|axon|dendrite|intracellular signal transduction|metal ion binding|adenylate cyclase-activating adrenergic receptor signaling pathway","WP35,WP4321,WP4941,WP289,WP4589,WP4222,WP3929,WP5085,WP4535,WP536","G protein signaling pathways|Thermogenesis|GPR143 in melanocytes and retinal pigment epithelium cells|Myometrial relaxation and contraction pathways|Major receptors targeted by epinephrine and norepinephrine|Phosphodiesterases in neuronal function|Chemokine signaling pathway|Vasopressin-regulated water reabsorption|Envelope proteins and their potential roles in EDMD physiopathology|Calcium regulation in cardiac cells","R-HSA-111885,R-HSA-111885,R-HSA-111931,R-HSA-111933,R-HSA-111996,R-HSA-111997,R-HSA-112040,R-HSA-112040,R-HSA-112043,R-HSA-112314,R-HSA-112314,R-HSA-112315,R-HSA-112315,R-HSA-112316,R-HSA-112316,R-HSA-1430728,R-HSA-1489509,R-HSA-162582,R-HSA-162582,R-HSA-163359,R-HSA-163615,R-HSA-163685,R-HSA-1643685,R-HSA-1643685,R-HSA-164378,R-HSA-170660,R-HSA-170670,R-HSA-170670,R-HSA-372790,R-HSA-372790,R-HSA-382551,R-HSA-388396,R-HSA-388396,R-HSA-418555,R-HSA-418555,R-HSA-418594,R-HSA-418594,R-HSA-418597,R-HSA-418597,R-HSA-432040,R-HSA-445717,R-HSA-5358351,R-HSA-5610787,R-HSA-5663205,R-HSA-5663205,R-HSA-9006925,R-HSA-9634597,R-HSA-9634597,R-HSA-9658195,R-HSA-9658195,R-HSA-9660821,R-HSA-9660821,R-HSA-9662851,R-HSA-9662851,R-HSA-9664323,R-HSA-9664433,R-HSA-9664433,R-HSA-977443,R-HSA-977443,R-HSA-977444,R-HSA-977444,R-HSA-9824443,R-HSA-9824443,R-HSA-991365,R-HSA-991365","Opioid Signalling|Opioid Signalling|PKA-mediated phosphorylation of CREB|Calmodulin induced events|Ca-dependent events|CaM pathway|G-protein mediated events|G-protein mediated events|PLC beta mediated events|Neurotransmitter receptors and postsynaptic signal transmission|Neurotransmitter receptors and postsynaptic signal transmission|Transmission across Chemical Synapses|Transmission across Chemical Synapses|Neuronal System|Neuronal System|Metabolism|DAG and IP3 signaling|Signal Transduction|Signal Transduction|Glucagon signaling in metabolic regulation|PKA activation|Integration of energy metabolism|Disease|Disease|PKA activation in glucagon signalling|Adenylate cyclase activating pathway|Adenylate cyclase inhibitory pathway|Adenylate cyclase inhibitory pathway|Signaling by GPCR|Signaling by GPCR|Transport of small molecules|GPCR downstream signalling|GPCR downstream signalling|G alpha (s) signalling events|G alpha (s) signalling events|G alpha (i) signalling events|G alpha (i) signalling events|G alpha (z) signalling events|G alpha (z) signalling events|Vasopressin regulates renal water homeostasis via Aquaporins|Aquaporin-mediated transport|Signaling by Hedgehog|Hedgehog 'off' state|Infectious disease|Infectious disease|Intracellular signaling by second messengers|GPER1 signaling|GPER1 signaling|Leishmania infection|Leishmania infection|ADORA2B mediated anti-inflammatory cytokines production|ADORA2B mediated anti-inflammatory cytokines production|Anti-inflammatory response favouring Leishmania parasite infection|Anti-inflammatory response favouring Leishmania parasite infection|FCGR3A-mediated IL10 synthesis|Leishmania parasite growth and survival|Leishmania parasite growth and survival|GABA receptor activation|GABA receptor activation|GABA B receptor activation|GABA B receptor activation|Parasitic Infection Pathways|Parasitic Infection Pathways|Activation of GABAB receptors|Activation of GABAB receptors"]
["ADCYAP1",0,0,0,0,0,0,0,0,0,0,0,0,0,0.0288433793901193,0,0,0,0,0,0,0.00713879630160634,0,0.00746681223055827,0,0,0,0,0,116,"adenylate cyclase activating polypeptide 1","protein_coding","hsa04024,hsa04080,hsa04911,hsa04924,hsa04713","cAMP signaling pathway|Neuroactive ligand-receptor interaction|Insulin secretion|Renin secretion|Circadian entrainment","GO:0005102,GO:0005184,GO:0005515,GO:0005576,GO:0007189,GO:0007190,GO:0007204,GO:0007218,GO:0007267,GO:0007565,GO:0008277,GO:0016521,GO:0019933,GO:0030073,GO:0031175,GO:0032880,GO:0043005,GO:0043204,GO:0043547,GO:0045786,GO:0045860,GO:0045944,GO:0051428,GO:0060124,GO:0070374,GO:0071651,GO:0120162","signaling receptor binding|neuropeptide hormone activity|protein binding|extracellular region|adenylate cyclase-activating G protein-coupled receptor signaling pathway|activation of adenylate cyclase activity|positive regulation of cytosolic calcium ion concentration|neuropeptide signaling pathway|cell-cell signaling|female pregnancy|regulation of G protein-coupled receptor signaling pathway|pituitary adenylate cyclase activating polypeptide activity|cAMP-mediated signaling|insulin secretion|neuron projection development|regulation of protein localization|neuron projection|perikaryon|positive regulation of GTPase activity|negative regulation of cell cycle|positive regulation of protein kinase activity|positive regulation of transcription by RNA polymerase II|peptide hormone receptor binding|positive regulation of growth hormone secretion|positive regulation of ERK1 and ERK2 cascade|positive regulation of chemokine (C-C motif) ligand 5 production|positive regulation of cold-induced thermogenesis","WP706","Sudden infant death syndrome (SIDS) susceptibility pathways","R-HSA-162582,R-HSA-162582,R-HSA-166520,R-HSA-187015,R-HSA-187024,R-HSA-187037,R-HSA-372790,R-HSA-373080,R-HSA-388396,R-HSA-418555,R-HSA-420092,R-HSA-500792,R-HSA-9006934","Signal Transduction|Signal Transduction|Signaling by NTRKs|Activation of TRKA receptors|NGF-independant TRKA activation|Signaling by NTRK1 (TRKA)|Signaling by GPCR|Class B/2 (Secretin family receptors)|GPCR downstream signalling|G alpha (s) signalling events|Glucagon-type ligand receptors|GPCR ligand binding|Signaling by Receptor Tyrosine Kinases"]
["ADCYAP1R1",0,0,0,0,0,0,0,0,0,0,0,0.00398416221787488,0,0,0.0036828455086992,0,0,0,0,0,0,0,0,0,0,0,0,0,117,"ADCYAP receptor type I","protein_coding","hsa04024,hsa04080,hsa04911,hsa04924,hsa04713","cAMP signaling pathway|Neuroactive ligand-receptor interaction|Insulin secretion|Renin secretion|Circadian entrainment","GO:0004999,GO:0005515,GO:0005768,GO:0005886,GO:0005901,GO:0005923,GO:0007166,GO:0007188,GO:0007283,GO:0008179,GO:0008528,GO:0009410,GO:0009986,GO:0010524,GO:0017046,GO:0019933,GO:0030154,GO:0031267,GO:0032355,GO:0033555,GO:0038023,GO:0042923,GO:0043231,GO:0043235,GO:0043950,GO:0045471,GO:0046545,GO:0051057,GO:0060732,GO:1901032","vasoactive intestinal polypeptide receptor activity|protein binding|endosome|plasma membrane|caveola|bicellular tight junction|cell surface receptor signaling pathway|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|spermatogenesis|adenylate cyclase binding|G protein-coupled peptide receptor activity|response to xenobiotic stimulus|cell surface|positive regulation of calcium ion transport into cytosol|peptide hormone binding|cAMP-mediated signaling|cell differentiation|small GTPase binding|response to estradiol|multicellular organismal response to stress|signaling receptor activity|neuropeptide binding|intracellular membrane-bounded organelle|receptor complex|positive regulation of cAMP-mediated signaling|response to ethanol|development of primary female sexual characteristics|positive regulation of small GTPase mediated signal transduction|positive regulation of inositol phosphate biosynthetic process|negative regulation of response to reactive oxygen species","WP706,WP334","Sudden infant death syndrome (SIDS) susceptibility pathways|GPCRs, class B secretin-like","R-HSA-162582,R-HSA-162582,R-HSA-166520,R-HSA-187015,R-HSA-187024,R-HSA-187037,R-HSA-372790,R-HSA-373080,R-HSA-388396,R-HSA-418555,R-HSA-420092,R-HSA-500792,R-HSA-9006934","Signal Transduction|Signal Transduction|Signaling by NTRKs|Activation of TRKA receptors|NGF-independant TRKA activation|Signaling by NTRK1 (TRKA)|Signaling by GPCR|Class B/2 (Secretin family receptors)|GPCR downstream signalling|G alpha (s) signalling events|Glucagon-type ligand receptors|GPCR ligand binding|Signaling by Receptor Tyrosine Kinases"]
["ADD1",64.6487388939449,71.8234762963682,72.2915443968521,72.8924972509586,67.4228063089819,71.3225856709976,69.765651488717,69.0597074365442,72.6074146704423,86.2360444125494,82.5565306143672,75.247050743617,69.1454634870747,77.178398119831,74.065442196922,76.8150712067746,65.4149922289421,73.0964256507205,71.7578897035228,72.416169158732,66.9820263453264,71.73108453349,62.0093972966371,63.3804928708645,64.7393654726764,71.0110860691857,61.1680600197572,71.6994481051134,118,"adducin 1","protein_coding",null,null,"GO:0003723,GO:0003779,GO:0005515,GO:0005516,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005856,GO:0005886,GO:0005912,GO:0005925,GO:0008290,GO:0014069,GO:0016604,GO:0030036,GO:0030507,GO:0032092,GO:0042803,GO:0045296,GO:0046982,GO:0046983,GO:0051015,GO:0051016,GO:0051017,GO:0061629,GO:0071277,GO:1903142,GO:1903393","RNA binding|actin binding|protein binding|calmodulin binding|nucleus|nucleoplasm|cytoplasm|cytosol|cytoskeleton|plasma membrane|adherens junction|focal adhesion|F-actin capping protein complex|postsynaptic density|nuclear body|actin cytoskeleton organization|spectrin binding|positive regulation of protein binding|protein homodimerization activity|cadherin binding|protein heterodimerization activity|protein dimerization activity|actin filament binding|barbed-end actin filament capping|actin filament bundle assembly|RNA polymerase II-specific DNA-binding transcription factor binding|cellular response to calcium ion|positive regulation of establishment of endothelial barrier|positive regulation of adherens junction organization",null,null,"R-HSA-109581,R-HSA-111465,R-HSA-2262752,R-HSA-264870,R-HSA-381038,R-HSA-381070,R-HSA-381119,R-HSA-382551,R-HSA-5223345,R-HSA-5357801,R-HSA-75153,R-HSA-8953897","Apoptosis|Apoptotic cleavage of cellular proteins|Cellular responses to stress|Caspase-mediated cleavage of cytoskeletal proteins|XBP1(S) activates chaperone genes|IRE1alpha activates chaperones|Unfolded Protein Response (UPR)|Transport of small molecules|Miscellaneous transport and binding events|Programmed Cell Death|Apoptotic execution phase|Cellular responses to stimuli"]
["ADD2",0,0,0,0,0,0,0,0,0.0264131493709883,0.00919670221198904,0.0179601572908397,0.0144103040473296,0.0204318185509914,0.0113794947912665,0.00888031504701222,0.0113171213014288,0,0.00883515287652327,0,0.00459115625999181,0,0.0022691176145754,0.00471337562694113,0.00233222496082842,0,0,0.00462009110785402,0.0067327208441719,119,"adducin 2","protein_coding",null,null,"GO:0003779,GO:0005200,GO:0005516,GO:0005829,GO:0005856,GO:0005886,GO:0007416,GO:0008290,GO:0014069,GO:0019901,GO:0030036,GO:0030097,GO:0030507,GO:0031410,GO:0032092,GO:0042803,GO:0044853,GO:0046982,GO:0046983,GO:0050900,GO:0050901,GO:0051015,GO:0051016,GO:0051017,GO:0065003","actin binding|structural constituent of cytoskeleton|calmodulin binding|cytosol|cytoskeleton|plasma membrane|synapse assembly|F-actin capping protein complex|postsynaptic density|protein kinase binding|actin cytoskeleton organization|hemopoiesis|spectrin binding|cytoplasmic vesicle|positive regulation of protein binding|protein homodimerization activity|plasma membrane raft|protein heterodimerization activity|protein dimerization activity|leukocyte migration|leukocyte tethering or rolling|actin filament binding|barbed-end actin filament capping|actin filament bundle assembly|protein-containing complex assembly",null,null,"R-HSA-382551,R-HSA-5223345","Transport of small molecules|Miscellaneous transport and binding events"]
["ADD3",23.7898406805835,22.8768434267799,19.4760457321302,16.2093701379022,26.3632962829804,21.7171279650049,19.8689481190597,19.3073959622452,22.4214390838804,14.2045933658623,14.5727353376915,17.065235296676,27.4693741444552,19.238968802691,24.2569451792344,24.5932762982768,21.7499696183906,17.297534856447,18.6376527950303,24.3678052480034,21.7355866014066,19.6788305211505,29.9220469413055,26.0434761162173,23.1135288337382,16.9157519771807,24.0920509978249,16.5126674097918,120,"adducin 3","protein_coding",null,null,"GO:0000794,GO:0005080,GO:0005200,GO:0005516,GO:0005829,GO:0005856,GO:0005886,GO:0005903,GO:0005911,GO:0005938,GO:0007010,GO:0009410,GO:0014069,GO:0016020,GO:0045907,GO:0051015,GO:0051016,GO:0051495","condensed nuclear chromosome|protein kinase C binding|structural constituent of cytoskeleton|calmodulin binding|cytosol|cytoskeleton|plasma membrane|brush border|cell-cell junction|cell cortex|cytoskeleton organization|response to xenobiotic stimulus|postsynaptic density|membrane|positive regulation of vasoconstriction|actin filament binding|barbed-end actin filament capping|positive regulation of cytoskeleton organization",null,null,"R-HSA-162582,R-HSA-194315,R-HSA-382551,R-HSA-5223345,R-HSA-9012999,R-HSA-9013405,R-HSA-9035034,R-HSA-9716542","Signal Transduction|Signaling by Rho GTPases|Transport of small molecules|Miscellaneous transport and binding events|RHO GTPase cycle|RHOD GTPase cycle|RHOF GTPase cycle|Signaling by Rho GTPases, Miro GTPases and RHOBTB3"]
["ADD3-AS1",0.40013131989814,0.200311195781816,0.197714528868358,0.323157241074784,0.576197974195918,0.3559677161772,0.117890181479453,0.413018447188091,0.381294821629943,0.0811321573263908,0.356495090850286,0.190688851526304,0.280384143323709,0.180699265101068,0.332949374547784,0.319482334339336,0.303712126077405,0.175370882135802,0.233564147028966,0.303769549733364,0.695698008329981,0.460411054989895,0.436598511393674,0.576088718136631,0.417578401781404,0.180093185112511,0.203789331210498,0.158387257859144,100505933,"ADD3 antisense RNA 1","non_coding"]
["ADGB",0,0,0,0,0,0,0,0.00497051158706991,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,79747,"androglobin","protein_coding",null,null,"GO:0004198,GO:0006508,GO:0007283,GO:0019825,GO:0020037,GO:0030154,GO:0031514","calcium-dependent cysteine-type endopeptidase activity|proteolysis|spermatogenesis|oxygen binding|heme binding|cell differentiation|motile cilium"]
["ADGRA2",39.0524949080379,50.6654508122751,57.615699628228,46.7432917932784,45.4995808398891,56.8095531527844,61.5066344234341,51.859993177114,65.6109574085981,90.7477004439444,70.7168055496087,63.1811921349723,67.5951333266566,82.9359726023454,78.8892936313708,81.0563992361748,42.6020964728173,47.2692559043949,44.7611883084174,50.1098041327162,49.7824494509752,47.3473337272145,36.9786396129646,41.8971906263903,46.144765364173,44.2726155412226,36.7414757954163,44.9889373528325,25960,"adhesion G protein-coupled receptor A2","protein_coding",null,null,"GO:0002040,GO:0004930,GO:0005515,GO:0005886,GO:0007166,GO:0007186,GO:0007417,GO:0009986,GO:0010595,GO:0016020,GO:0030175,GO:0043231,GO:0043542,GO:0045765,GO:0050920,GO:0060070,GO:0090210,GO:0090263,GO:1900747,GO:1990909","sprouting angiogenesis|G protein-coupled receptor activity|protein binding|plasma membrane|cell surface receptor signaling pathway|G protein-coupled receptor signaling pathway|central nervous system development|cell surface|positive regulation of endothelial cell migration|membrane|filopodium|intracellular membrane-bounded organelle|endothelial cell migration|regulation of angiogenesis|regulation of chemotaxis|canonical Wnt signaling pathway|regulation of establishment of blood-brain barrier|positive regulation of canonical Wnt signaling pathway|negative regulation of vascular endothelial growth factor signaling pathway|Wnt signalosome"]
["ADGRA3",9.4999877481033,9.61437264349504,8.89217174134429,7.81271779303268,8.61925447919906,8.31880697071183,9.31986802095896,8.23504199757301,11.5862861119857,11.4142580457075,11.0247895428261,11.8659801365631,11.2207299103914,11.1492596391366,13.1905586470235,12.0879730095757,8.9144548573505,8.91306413477045,9.44298817521165,9.55561761520134,7.85024056442955,7.97356814084319,10.1898264193901,9.77777362659389,9.14537170054751,7.83517307439667,10.1490318844116,7.93527139286552,166647,"adhesion G protein-coupled receptor A3","protein_coding",null,null,"GO:0004930,GO:0005886,GO:0007166,GO:0007186,GO:0009897,GO:0016020","G protein-coupled receptor activity|plasma membrane|cell surface receptor signaling pathway|G protein-coupled receptor signaling pathway|external side of plasma membrane|membrane"]
["ADGRB1",0,0.00398134053727834,0.0196486488316381,0.0240862539931516,0.012270409388378,3.9306304063735E-3,0,0.00410453115217978,0.00421029478680406,0.0201570577208424,0,0.00842241994319079,0,0.0119717939611473,0,0.00793744930035618,0.0241460572285142,0.00387292493329583,3.86855730068682E-3,0,0,0.0119361224085957,0,0.0245361654574608,0,0.00795442639558368,0.0040504711793391,0.0196754357588998,575,"adhesion G protein-coupled receptor B1","protein_coding","hsa04115","p53 signaling pathway","GO:0001530,GO:0001786,GO:0001891,GO:0004930,GO:0005515,GO:0005615,GO:0005886,GO:0005911,GO:0005925,GO:0006910,GO:0007155,GO:0007165,GO:0007166,GO:0007186,GO:0007189,GO:0007409,GO:0007422,GO:0007517,GO:0008285,GO:0010596,GO:0014069,GO:0016020,GO:0016525,GO:0030165,GO:0030425,GO:0031397,GO:0042177,GO:0043197,GO:0043277,GO:0043652,GO:0045087,GO:0048167,GO:0048471,GO:0050829,GO:0051965,GO:1901741,GO:1903428","lipopolysaccharide binding|phosphatidylserine binding|phagocytic cup|G protein-coupled receptor activity|protein binding|extracellular space|plasma membrane|cell-cell junction|focal adhesion|phagocytosis, recognition|cell adhesion|signal transduction|cell surface receptor signaling pathway|G protein-coupled receptor signaling pathway|adenylate cyclase-activating G protein-coupled receptor signaling pathway|axonogenesis|peripheral nervous system development|muscle organ development|negative regulation of cell population proliferation|negative regulation of endothelial cell migration|postsynaptic density|membrane|negative regulation of angiogenesis|PDZ domain binding|dendrite|negative regulation of protein ubiquitination|negative regulation of protein catabolic process|dendritic spine|apoptotic cell clearance|engulfment of apoptotic cell|innate immune response|regulation of synaptic plasticity|perinuclear region of cytoplasm|defense response to Gram-negative bacterium|positive regulation of synapse assembly|positive regulation of myoblast fusion|positive regulation of reactive oxygen species biosynthetic process","WP4963","p53 transcriptional gene network"]
["ADGRB2",2.98658755334236,2.94834407355207,2.00097591344898,2.81223289865986,2.98911594470038,3.48445073862299,2.09406632023041,2.72452121885231,2.43969514132646,3.29050347659157,2.61295415105531,2.76801693268108,2.37115192934297,2.92931463049335,1.79275627243693,2.31258657994161,2.07960637031167,2.48285890318317,1.17102275047817,2.28016688934208,2.54127726393493,2.275390542035,1.03194679208039,1.75068856237017,2.57963491447971,2.45512295777204,0.906429766619668,2.07177020855875,576,"adhesion G protein-coupled receptor B2","protein_coding",null,null,"GO:0004930,GO:0005515,GO:0005576,GO:0005886,GO:0007166,GO:0007186,GO:0007189,GO:0007422,GO:0016020,GO:0016525,GO:0033173","G protein-coupled receptor activity|protein binding|extracellular region|plasma membrane|cell surface receptor signaling pathway|G protein-coupled receptor signaling pathway|adenylate cyclase-activating G protein-coupled receptor signaling pathway|peripheral nervous system development|membrane|negative regulation of angiogenesis|calcineurin-NFAT signaling cascade"]
["ADGRB3",0.0177052316816046,0,0.00415557630462231,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,577,"adhesion G protein-coupled receptor B3","protein_coding",null,null,"GO:0004930,GO:0005096,GO:0005515,GO:0005886,GO:0007166,GO:0007186,GO:0007189,GO:0007520,GO:0016020,GO:0016322,GO:0016525,GO:0043083,GO:0048814,GO:0051965,GO:0061743,GO:0090128,GO:0098794,GO:0098839,GO:0099558,GO:0150053,GO:1905806","G protein-coupled receptor activity|GTPase activator activity|protein binding|plasma membrane|cell surface receptor signaling pathway|G protein-coupled receptor signaling pathway|adenylate cyclase-activating G protein-coupled receptor signaling pathway|myoblast fusion|membrane|neuron remodeling|negative regulation of angiogenesis|synaptic cleft|regulation of dendrite morphogenesis|positive regulation of synapse assembly|motor learning|regulation of synapse maturation|postsynapse|postsynaptic density membrane|maintenance of synapse structure|cerebellar climbing fiber to Purkinje cell synapse|regulation of synapse pruning"]
["ADGRB3-DT",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.191450087993609,0,0.0467071845888112,0,0,0,0,0,0,0,0,0,0,101928307,"ADGRB3 divergent transcript","non_coding"]
["ADGRD1",0,0.0156595071620964,0,2.63157362438749E-3,0.00536247532988291,0.00515335093995223,0,8.07202176914836E-3,0.0634801367896395,0.0317128953718791,0.0283854216384592,0.0193242411970196,0.0704548335946035,0.04970374284358,0.00765547517641964,0.054634601149235,0.0105524300048609,7.61654211230411E-3,0,0.00527721259037332,0.0129492416627264,0.0286901096438965,0.0027088475966724,0.00536145852151355,0.0136019023381564,0.0182504856429617,0,0.0128979851676827,283383,"adhesion G protein-coupled receptor D1","protein_coding",null,null,"GO:0004930,GO:0005515,GO:0005654,GO:0005829,GO:0005886,GO:0007166,GO:0007186,GO:0007189,GO:0016020,GO:0016607","G protein-coupled receptor activity|protein binding|nucleoplasm|cytosol|plasma membrane|cell surface receptor signaling pathway|G protein-coupled receptor signaling pathway|adenylate cyclase-activating G protein-coupled receptor signaling pathway|membrane|nuclear speck","WP117","GPCRs, other"]
["ADGRE1",0,0,0,0,0,0,0,7.51583185102013E-3,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,2015,"adhesion G protein-coupled receptor E1","protein_coding",null,null,"GO:0002250,GO:0004930,GO:0005509,GO:0005886,GO:0007155,GO:0007166,GO:0007186,GO:0007189,GO:0009897","adaptive immune response|G protein-coupled receptor activity|calcium ion binding|plasma membrane|cell adhesion|cell surface receptor signaling pathway|G protein-coupled receptor signaling pathway|adenylate cyclase-activating G protein-coupled receptor signaling pathway|external side of plasma membrane","WP334","GPCRs, class B secretin-like","R-HSA-162582,R-HSA-372790,R-HSA-373080,R-HSA-500792","Signal Transduction|Signaling by GPCR|Class B/2 (Secretin family receptors)|GPCR ligand binding"]
["ADGRE2",0.0233849927682119,0.0127102902764023,0.00627276234853138,0.0352433228585711,0.00326440436490083,0.00313709998971934,0.00311685529585865,0.0131035720015059,0.0336030467555065,0.0193052103193296,0.0188504860696644,0.00336103509940195,0.0031769886820313,0.00955488327051543,3.10684463721843E-3,0.00633500724926184,0.0835092291969765,0,0,0.00642500142369903,0.0409907931894937,0.00635094214990344,0.00329801943112029,0,0.0298085462171382,0,0.0323274685772013,0.00628131398127724,30817,"adhesion G protein-coupled receptor E2","protein_coding",null,null,"GO:0004930,GO:0005509,GO:0005515,GO:0005886,GO:0006954,GO:0007155,GO:0007166,GO:0007186,GO:0007189,GO:0016020,GO:0016477,GO:0031256,GO:0032587,GO:0035374,GO:0043304,GO:0071621","G protein-coupled receptor activity|calcium ion binding|protein binding|plasma membrane|inflammatory response|cell adhesion|cell surface receptor signaling pathway|G protein-coupled receptor signaling pathway|adenylate cyclase-activating G protein-coupled receptor signaling pathway|membrane|cell migration|leading edge membrane|ruffle membrane|chondroitin sulfate binding|regulation of mast cell degranulation|granulocyte chemotaxis","WP334,WP117","GPCRs, class B secretin-like|GPCRs, other","R-HSA-162582,R-HSA-372790,R-HSA-373080,R-HSA-500792","Signal Transduction|Signaling by GPCR|Class B/2 (Secretin family receptors)|GPCR ligand binding"]
["ADGRE5",15.3539267190431,13.994708422823,11.0520836297547,13.7924843097897,13.2607565195408,12.0042263049905,10.7167981697702,11.0668127338188,10.0552739011994,12.1930573209879,10.7588285531907,10.0496932213328,9.05891756796484,8.06603617872554,7.68154880703196,7.19475680768768,8.71314024625885,10.0566507133902,7.59105773008998,8.2768213321775,8.22588042708085,9.10595339198103,5.98230219069934,6.5914127265772,7.8292362890699,9.47661021419331,6.16270142492229,8.80292067734899,976,"adhesion G protein-coupled receptor E5","protein_coding",null,null,"GO:0004888,GO:0004930,GO:0005509,GO:0005515,GO:0005886,GO:0005925,GO:0006954,GO:0006955,GO:0007155,GO:0007166,GO:0007186,GO:0007189,GO:0007267,GO:0016020,GO:0030667,GO:0070062","transmembrane signaling receptor activity|G protein-coupled receptor activity|calcium ion binding|protein binding|plasma membrane|focal adhesion|inflammatory response|immune response|cell adhesion|cell surface receptor signaling pathway|G protein-coupled receptor signaling pathway|adenylate cyclase-activating G protein-coupled receptor signaling pathway|cell-cell signaling|membrane|secretory granule membrane|extracellular exosome","WP334,WP2877","GPCRs, class B secretin-like|Vitamin D receptor pathway","R-HSA-162582,R-HSA-168249,R-HSA-168256,R-HSA-372790,R-HSA-373080,R-HSA-500792,R-HSA-6798695","Signal Transduction|Innate Immune System|Immune System|Signaling by GPCR|Class B/2 (Secretin family receptors)|GPCR ligand binding|Neutrophil degranulation"]
["ADGRF3",0.0496853534748561,0.0109059264398437,0.0502345719172123,0.0366547274719733,3.7346489182454E-3,0.0287120485660517,0.0606193664396453,0.0374779251666494,0.0153774555094389,0.0773015875844813,0.00359432326896644,0.0422971947239214,0.0290771265280709,0.007287523333786,0.010663177106642,0.0398616835699157,0.0404203103659895,0.0282905277985824,0.0317909515309525,0.0404279527411103,0.0396808975199454,0.0290632367546127,0.0226386378474774,0.0410733484807061,0.0454700428992086,0.032683861753015,0.0517780350955924,0.0143723018615982,165082,"adhesion G protein-coupled receptor F3","protein_coding",null,null,"GO:0004930,GO:0007166,GO:0007186,GO:0007189,GO:0016020","G protein-coupled receptor activity|cell surface receptor signaling pathway|G protein-coupled receptor signaling pathway|adenylate cyclase-activating G protein-coupled receptor signaling pathway|membrane"]
["ADGRF4",0,0,0.0080906201071451,0.00826489107608145,0.00842086918810257,0,0,0,0,0,0,0,0,0,0,0,0,0,0.0318587071821267,0,0,0.00819145655491862,0,0,0,0,0,0,221393,"adhesion G protein-coupled receptor F4","protein_coding",null,null,"GO:0004930,GO:0005515,GO:0007166,GO:0007186,GO:0007189,GO:0016020","G protein-coupled receptor activity|protein binding|cell surface receptor signaling pathway|G protein-coupled receptor signaling pathway|adenylate cyclase-activating G protein-coupled receptor signaling pathway|membrane","WP2882,WP2880","Nuclear receptors meta-pathway|Glucocorticoid receptor pathway"]
["ADGRF5",0,0,0,0,8.42221545016302E-3,0.00404688406347647,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,221395,"adhesion G protein-coupled receptor F5","protein_coding",null,null,"GO:0003094,GO:0004930,GO:0005515,GO:0005886,GO:0006112,GO:0007166,GO:0007186,GO:0007189,GO:0008654,GO:0009986,GO:0016020,GO:0019216,GO:0031410,GO:0042116,GO:0042593,GO:0043031,GO:0043129,GO:0045177,GO:0045444,GO:0048821,GO:0061626,GO:0071073","glomerular filtration|G protein-coupled receptor activity|protein binding|plasma membrane|energy reserve metabolic process|cell surface receptor signaling pathway|G protein-coupled receptor signaling pathway|adenylate cyclase-activating G protein-coupled receptor signaling pathway|phospholipid biosynthetic process|cell surface|membrane|regulation of lipid metabolic process|cytoplasmic vesicle|macrophage activation|glucose homeostasis|negative regulation of macrophage activation|surfactant homeostasis|apical part of cell|fat cell differentiation|erythrocyte development|pharyngeal arch artery morphogenesis|positive regulation of phospholipid biosynthetic process","WP117","GPCRs, other","R-HSA-392499,R-HSA-5683826","Metabolism of proteins|Surfactant metabolism"]
["ADGRF5-AS1",0,0,0,0,0,0,0,0,0.015654906713059,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,101926962,"ADGRF5 antisense RNA 1","non_coding"]
["ADGRG1",0.610296964828527,0.748100996491274,0.714193298157131,0.618285537770634,0.625754359731719,0.891937248017702,0.585441037278919,0.64481451448753,0.436630124542225,0.61263057572989,0.594158484750477,0.371864880527486,0.412810473406627,0.463016257515208,0.483635946221871,0.464553394319953,0.396685225897019,0.485153007269112,0.401190116495334,0.516614880498919,0.494898874730365,0.453466079005131,0.373378707508681,0.323315096913415,0.409056393581783,0.392039586639481,0.407578662420996,0.549506812980703,9289,"adhesion G protein-coupled receptor G1","protein_coding",null,null,"GO:0001525,GO:0004930,GO:0005515,GO:0005518,GO:0005886,GO:0007155,GO:0007166,GO:0007186,GO:0007189,GO:0007266,GO:0007267,GO:0007420,GO:0008201,GO:0008285,GO:0010573,GO:0016020,GO:0016477,GO:0021796,GO:0021801,GO:0021819,GO:0035025,GO:0045121,GO:0045785,GO:0050840,GO:0061351,GO:0061484,GO:0070062,GO:0070528,GO:0072520,GO:0097451,GO:2000179,GO:2001223","angiogenesis|G protein-coupled receptor activity|protein binding|collagen binding|plasma membrane|cell adhesion|cell surface receptor signaling pathway|G protein-coupled receptor signaling pathway|adenylate cyclase-activating G protein-coupled receptor signaling pathway|Rho protein signal transduction|cell-cell signaling|brain development|heparin binding|negative regulation of cell population proliferation|vascular endothelial growth factor production|membrane|cell migration|cerebral cortex regionalization|cerebral cortex radial glia-guided migration|layer formation in cerebral cortex|positive regulation of Rho protein signal transduction|membrane raft|positive regulation of cell adhesion|extracellular matrix binding|neural precursor cell proliferation|hematopoietic stem cell homeostasis|extracellular exosome|protein kinase C signaling|seminiferous tubule development|glial limiting end-foot|positive regulation of neural precursor cell proliferation|negative regulation of neuron migration","WP117","GPCRs, other"]
["ADGRG2",0.00489578918184582,0,0,0,0.0382716728229347,0,0.00456772709449391,0.00480079560843404,0,0.0188610899705376,0.00920841337305498,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,10149,"adhesion G protein-coupled receptor G2","protein_coding",null,null,"GO:0004930,GO:0005829,GO:0005886,GO:0007166,GO:0007186,GO:0007189,GO:0007283,GO:0009986,GO:0016020,GO:0016324,GO:0070062","G protein-coupled receptor activity|cytosol|plasma membrane|cell surface receptor signaling pathway|G protein-coupled receptor signaling pathway|adenylate cyclase-activating G protein-coupled receptor signaling pathway|spermatogenesis|cell surface|membrane|apical plasma membrane|extracellular exosome","WP334","GPCRs, class B secretin-like"]
["ADGRG4",0,0.0024970620432482,0,0,0,0,0,0,0,0,0,0,0,0,0,0,2.52403273197687E-3,0,0,0,0,0,0,0,0,0,0,0,139378,"adhesion G protein-coupled receptor G4","protein_coding",null,null,"GO:0004930,GO:0007166,GO:0007186,GO:0007189,GO:0016020","G protein-coupled receptor activity|cell surface receptor signaling pathway|G protein-coupled receptor signaling pathway|adenylate cyclase-activating G protein-coupled receptor signaling pathway|membrane"]
["ADGRG5",0,0,0,0,0,0,0,0,0.00555507035997094,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,221188,"adhesion G protein-coupled receptor G5","protein_coding",null,null,"GO:0004930,GO:0005886,GO:0007166,GO:0007186,GO:0007189,GO:0016020","G protein-coupled receptor activity|plasma membrane|cell surface receptor signaling pathway|G protein-coupled receptor signaling pathway|adenylate cyclase-activating G protein-coupled receptor signaling pathway|membrane"]
["ADGRG6",0.00330062632977141,0,0,0,0.0096756993340461,0,0,0,0,0,0,0.00332070432436321,0,0,0,0,0.00317335228259319,0.0122158131849762,0.00305050924653154,0,0,0,0,0.0193477293432163,0,0,0.00319395547874908,0,57211,"adhesion G protein-coupled receptor G6","protein_coding",null,null,"GO:0004175,GO:0004930,GO:0005518,GO:0005737,GO:0005789,GO:0005886,GO:0007166,GO:0007186,GO:0007189,GO:0007399,GO:0009986,GO:0014037,GO:0016020,GO:0019933,GO:0022011,GO:0042552,GO:0043236,GO:0050840,GO:0060347","endopeptidase activity|G protein-coupled receptor activity|collagen binding|cytoplasm|endoplasmic reticulum membrane|plasma membrane|cell surface receptor signaling pathway|G protein-coupled receptor signaling pathway|adenylate cyclase-activating G protein-coupled receptor signaling pathway|nervous system development|cell surface|Schwann cell differentiation|membrane|cAMP-mediated signaling|myelination in peripheral nervous system|myelination|laminin binding|extracellular matrix binding|heart trabecula formation",null,null,"R-HSA-1266738,R-HSA-9619665,R-HSA-9675108","Developmental Biology|EGR2 and SOX10-mediated initiation of Schwann cell myelination|Nervous system development"]
["ADGRG7",0,0,0.0063875466166456,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,84873,"adhesion G protein-coupled receptor G7","protein_coding",null,null,"GO:0004930,GO:0005515,GO:0007166,GO:0007186,GO:0007189,GO:0016020","G protein-coupled receptor activity|protein binding|cell surface receptor signaling pathway|G protein-coupled receptor signaling pathway|adenylate cyclase-activating G protein-coupled receptor signaling pathway|membrane"]
["ADGRL1",0.210890520873574,0.149695428888793,0.265958824446927,0.156975026024183,0.209149061161393,0.206904272208451,0.276049872248323,0.194452402973188,0.680706931551718,0.839742459763111,0.825883068947884,0.665021060904438,0.643572064478254,0.960278413324478,0.731817181740878,0.641650648135986,0.184600987109791,0.279588639743206,0.203636808868474,0.323869512155391,0.297088627030885,0.305176712118883,0.264128455993148,0.32903979630677,0.35575105317575,0.239264390413633,0.32286474146007,0.322544812828523,22859,"adhesion G protein-coupled receptor L1","protein_coding",null,null,"GO:0004930,GO:0005515,GO:0005886,GO:0007157,GO:0007166,GO:0007186,GO:0007189,GO:0016020,GO:0016524,GO:0030246,GO:0030424,GO:0030426,GO:0035584,GO:0042734,GO:0043005,GO:0045202,GO:0050839,GO:0090129","G protein-coupled receptor activity|protein binding|plasma membrane|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules|cell surface receptor signaling pathway|G protein-coupled receptor signaling pathway|adenylate cyclase-activating G protein-coupled receptor signaling pathway|membrane|latrotoxin receptor activity|carbohydrate binding|axon|growth cone|calcium-mediated signaling using intracellular calcium source|presynaptic membrane|neuron projection|synapse|cell adhesion molecule binding|positive regulation of synapse maturation","WP334","GPCRs, class B secretin-like"]
["ADGRL1-AS1",0.88671760642247,0.825659444108984,1.03403055541124,0.922027585338028,1.00327308526396,0.622313520432902,0.722798527260916,0.970192917494463,0.685368346666318,0.701197592405372,1.07091169181249,1.1926123308755,0.772249164041558,0.685200044950802,1.01561223587005,1.00889158212422,0.475619359027958,0.785903368389436,0.802270200321105,0.637270929819209,0.81050056846991,0.727519335356789,0.635806300723673,0.693039059412489,0.879112424802956,0.49665587522564,0.496771776912018,0.886266650624573,100507373,"ADGRL1 antisense RNA 1","non_coding"]
["ADGRL2",1.41780699920014,1.35828910922863,1.0600736528863,0.957956643368012,1.40039884554927,1.25702692798822,1.15357791935416,1.13227801746181,5.45266691263576,4.19992699184683,4.15625647154238,4.50546786926945,5.83058112402818,5.63575906924601,6.90636458500938,6.89345506845906,1.04629863600889,0.902928844759517,1.47327801613419,1.53535279117192,1.20558519801578,1.21898064860692,2.017567762677,1.40512487083688,1.23595608836588,0.96850719716812,1.82437029790262,1.15278064855783,23266,"adhesion G protein-coupled receptor L2","protein_coding",null,null,"GO:0004930,GO:0007166,GO:0007186,GO:0007189,GO:0016020,GO:0016524,GO:0030246","G protein-coupled receptor activity|cell surface receptor signaling pathway|G protein-coupled receptor signaling pathway|adenylate cyclase-activating G protein-coupled receptor signaling pathway|membrane|latrotoxin receptor activity|carbohydrate binding","WP334,WP117","GPCRs, class B secretin-like|GPCRs, other"]
["ADGRL3",0.0226225776954571,0.00806918428326437,0.0119468731841777,0.0135602304148873,0.0124345297342493,0.0212437533214123,0.00527666517330888,0.00831886093470899,0.511993046615607,0.507943052634566,0.437471843864185,0.429598638843769,0.644071507079662,0.442141093102732,0.804736804571827,0.772187042557388,0.0530162053808342,0.0484049595124958,0.0470436047517037,0.0856577550152933,0.0520463745469748,0.0470391116513239,0.0628128688978198,0.044203278061662,0.0294374703380124,0.0470214453072269,0.0602014955875965,0.0212678405517654,23284,"adhesion G protein-coupled receptor L3","protein_coding",null,null,"GO:0001764,GO:0004930,GO:0005509,GO:0005515,GO:0005886,GO:0005911,GO:0007166,GO:0007186,GO:0007189,GO:0007416,GO:0016020,GO:0030246,GO:0030424,GO:0098742,GO:0098978","neuron migration|G protein-coupled receptor activity|calcium ion binding|protein binding|plasma membrane|cell-cell junction|cell surface receptor signaling pathway|G protein-coupled receptor signaling pathway|adenylate cyclase-activating G protein-coupled receptor signaling pathway|synapse assembly|membrane|carbohydrate binding|axon|cell-cell adhesion via plasma-membrane adhesion molecules|glutamatergic synapse","WP334,WP117","GPCRs, class B secretin-like|GPCRs, other"]
["ADGRL4",1.31772399991439,1.40551783375362,0.672195877746281,0.796250675945782,1.08666569872172,0.929845655895987,0.682224051059398,0.970984312123457,1.547637265402,0.953686845091229,1.11746789333121,0.996220680480267,1.76019626083652,0.994864309695874,1.28214535670147,1.55994765113979,0.62247111834269,0.66952683644826,1.11931278146687,1.03276496818079,0.977734705446115,0.82537662498772,1.79717456647092,0.87065602095166,0.898637216153482,0.810591787313732,1.00979082003597,0.91657842355334,64123,"adhesion G protein-coupled receptor L4","protein_coding",null,null,"GO:0004930,GO:0005509,GO:0005886,GO:0007166,GO:0007186,GO:0007189,GO:0016020,GO:0031410","G protein-coupled receptor activity|calcium ion binding|plasma membrane|cell surface receptor signaling pathway|G protein-coupled receptor signaling pathway|adenylate cyclase-activating G protein-coupled receptor signaling pathway|membrane|cytoplasmic vesicle","WP334","GPCRs, class B secretin-like"]
["ADGRV1",0,0.0026032930307719,1.28477305793227E-3,5.24978765072246E-3,0,0,0,0,0,0,0,0.00275359855996287,0,0.00652336557939799,1.2726738439291E-3,0.00129752191832403,0,0,0,0,0,0,1.35098582544977E-3,0,1.35673762382017E-3,2.60059427289871E-3,0,0,84059,"adhesion G protein-coupled receptor V1","protein_coding",null,null,"GO:0001917,GO:0001965,GO:0002141,GO:0002142,GO:0004930,GO:0005509,GO:0005515,GO:0005737,GO:0005886,GO:0007166,GO:0007186,GO:0007194,GO:0007399,GO:0007601,GO:0007605,GO:0009986,GO:0010739,GO:0010855,GO:0016020,GO:0016787,GO:0030501,GO:0031647,GO:0032420,GO:0043235,GO:0045184,GO:0045494,GO:0048496,GO:0048839,GO:0050877,GO:0050910,GO:0050953,GO:0060113,GO:0060122,GO:0060171,GO:0070062,GO:0071277,GO:0090037,GO:0097264,GO:0098609,GO:1990075,GO:1990696","photoreceptor inner segment|G-protein alpha-subunit binding|stereocilia ankle link|stereocilia ankle link complex|G protein-coupled receptor activity|calcium ion binding|protein binding|cytoplasm|plasma membrane|cell surface receptor signaling pathway|G protein-coupled receptor signaling pathway|negative regulation of adenylate cyclase activity|nervous system development|visual perception|sensory perception of sound|cell surface|positive regulation of protein kinase A signaling|adenylate cyclase inhibitor activity|membrane|hydrolase activity|positive regulation of bone mineralization|regulation of protein stability|stereocilium|receptor complex|establishment of protein localization|photoreceptor cell maintenance|maintenance of animal organ identity|inner ear development|nervous system process|detection of mechanical stimulus involved in sensory perception of sound|sensory perception of light stimulus|inner ear receptor cell differentiation|inner ear receptor cell stereocilium organization|stereocilium membrane|extracellular exosome|cellular response to calcium ion|positive regulation of protein kinase C signaling|self proteolysis|cell-cell adhesion|periciliary membrane compartment|USH2 complex","WP117","GPCRs, other","R-HSA-1266738,R-HSA-9619665,R-HSA-9675108","Developmental Biology|EGR2 and SOX10-mediated initiation of Schwann cell myelination|Nervous system development"]
["ADH1A",0,0,0.0348108111350067,0,0.0905793632062752,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.0366048401509073,0,0,0,0,0,124,"alcohol dehydrogenase 1A (class I)%2C alpha polypeptide","protein_coding","hsa00010,hsa00620,hsa00071,hsa00350,hsa00830,hsa00980,hsa00982,hsa04936","Glycolysis / Gluconeogenesis|Pyruvate metabolism|Fatty acid degradation|Tyrosine metabolism|Retinol metabolism|Metabolism of xenobiotics by cytochrome P450|Drug metabolism - cytochrome P450|Alcoholic liver disease","GO:0004022,GO:0004024,GO:0004745,GO:0005515,GO:0005654,GO:0005829,GO:0005886,GO:0006066,GO:0006069,GO:0008270,GO:0042572,GO:0042573,GO:1990362","alcohol dehydrogenase (NAD+) activity|alcohol dehydrogenase activity, zinc-dependent|NAD-retinol dehydrogenase activity|protein binding|nucleoplasm|cytosol|plasma membrane|alcohol metabolic process|ethanol oxidation|zinc ion binding|retinol metabolic process|retinoic acid metabolic process|butanol dehydrogenase activity","WP3996,WP5188,WP716,WP206","Ethanol effects on histone modifications|Retinol metabolism|Vitamin A and carotenoid metabolism|Fatty acid omega-oxidation","R-HSA-1430728,R-HSA-162582,R-HSA-211859,R-HSA-211945,R-HSA-2161522,R-HSA-2161541,R-HSA-5362517,R-HSA-5365859,R-HSA-71384,R-HSA-9006931,R-HSA-9748784","Metabolism|Signal Transduction|Biological oxidations|Phase I - Functionalization of compounds|Abacavir ADME|Abacavir metabolism|Signaling by Retinoic Acid|RA biosynthesis pathway|Ethanol oxidation|Signaling by Nuclear Receptors|Drug ADME"]
["ADH1B",0.82368000718814,1.38941086288767,1.35327547665637,1.4935125775144,1.00608178831739,1.67989645002115,1.86117705144613,1.34406003152734,0.0647273774815426,0.0185931895520017,0.0544657097503421,0.0582673024477606,0.0673159079561748,0.0674848320368966,0.119690281106304,0.0732162905146247,0.0309343137884203,0.0119081578278468,0,0.0185640975726286,0,0,0.0317638085339098,0.0251472754907372,0.00637980847792071,0.0244576299773496,0.0186810940999836,0.0120992892133984,125,"alcohol dehydrogenase 1B (class I)%2C beta polypeptide","protein_coding","hsa00010,hsa00620,hsa00071,hsa00350,hsa00830,hsa00980,hsa00982,hsa04936","Glycolysis / Gluconeogenesis|Pyruvate metabolism|Fatty acid degradation|Tyrosine metabolism|Retinol metabolism|Metabolism of xenobiotics by cytochrome P450|Drug metabolism - cytochrome P450|Alcoholic liver disease","GO:0001523,GO:0004024,GO:0004745,GO:0005654,GO:0005829,GO:0005886,GO:0006069,GO:0008270,GO:0042572,GO:0042573","retinoid metabolic process|alcohol dehydrogenase activity, zinc-dependent|NAD-retinol dehydrogenase activity|nucleoplasm|cytosol|plasma membrane|ethanol oxidation|zinc ion binding|retinol metabolic process|retinoic acid metabolic process","WP3996,WP206","Ethanol effects on histone modifications|Fatty acid omega-oxidation","R-HSA-1430728,R-HSA-211859,R-HSA-211945,R-HSA-71384","Metabolism|Biological oxidations|Phase I - Functionalization of compounds|Ethanol oxidation"]
["ADH1C",0.111236101383396,0.299777965626707,0.139243244540026,0.177803158775672,0.0724634905650202,0.0522281839416342,0.0518911390280951,0.236335177483144,0.0186480731960235,0.0714230821030126,0.0523055612435083,0.149217013573999,0.19393833454499,0.1944250078422,0.0344829840133638,0.0703124807349296,0,0,0,0.0356556647096475,0,0.0176223356972389,0.054907260226361,0.072449750364992,0,0.0352314346544421,0,0,126,"alcohol dehydrogenase 1C (class I)%2C gamma polypeptide","protein_coding","hsa00010,hsa00620,hsa00071,hsa00350,hsa00830,hsa00980,hsa00982,hsa04936","Glycolysis / Gluconeogenesis|Pyruvate metabolism|Fatty acid degradation|Tyrosine metabolism|Retinol metabolism|Metabolism of xenobiotics by cytochrome P450|Drug metabolism - cytochrome P450|Alcoholic liver disease","GO:0004022,GO:0004024,GO:0004745,GO:0005654,GO:0005829,GO:0005886,GO:0006069,GO:0008270,GO:0042572,GO:0042573","alcohol dehydrogenase (NAD+) activity|alcohol dehydrogenase activity, zinc-dependent|NAD-retinol dehydrogenase activity|nucleoplasm|cytosol|plasma membrane|ethanol oxidation|zinc ion binding|retinol metabolic process|retinoic acid metabolic process","WP3996,WP3925,WP206","Ethanol effects on histone modifications|Amino acid metabolism|Fatty acid omega-oxidation","R-HSA-1430728,R-HSA-162582,R-HSA-211859,R-HSA-211945,R-HSA-5362517,R-HSA-5365859,R-HSA-71384,R-HSA-9006931","Metabolism|Signal Transduction|Biological oxidations|Phase I - Functionalization of compounds|Signaling by Retinoic Acid|RA biosynthesis pathway|Ethanol oxidation|Signaling by Nuclear Receptors"]
["ADH5",115.519376375768,100.538696829447,109.064463369482,97.4930789740248,113.824241056414,111.67614625167,120.040536323131,114.673357101634,101.494585401587,76.0659864164171,88.3166252888432,95.0740675121192,112.419481555,103.669957462106,106.042795384318,108.209582200967,110.107174242787,86.1295277948544,109.546164645742,91.6837285550193,110.433851654542,96.2596963129768,129.165175060762,126.682418052471,110.245736723705,99.28515866367,133.11039610361,107.196878350761,128,"alcohol dehydrogenase 5 (class III)%2C chi polypeptide","protein_coding","hsa00010,hsa00620,hsa00071,hsa00350,hsa00830,hsa00980,hsa00982,hsa04936","Glycolysis / Gluconeogenesis|Pyruvate metabolism|Fatty acid degradation|Tyrosine metabolism|Retinol metabolism|Metabolism of xenobiotics by cytochrome P450|Drug metabolism - cytochrome P450|Alcoholic liver disease","GO:0001523,GO:0003016,GO:0004024,GO:0005504,GO:0005739,GO:0005829,GO:0006069,GO:0008270,GO:0009055,GO:0010430,GO:0018467,GO:0022900,GO:0032496,GO:0042802,GO:0045777,GO:0046294,GO:0051409,GO:0051775,GO:0051903,GO:0070062,GO:0106321,GO:0106322","retinoid metabolic process|respiratory system process|alcohol dehydrogenase activity, zinc-dependent|fatty acid binding|mitochondrion|cytosol|ethanol oxidation|zinc ion binding|electron transfer activity|fatty acid omega-oxidation|formaldehyde dehydrogenase activity|electron transport chain|response to lipopolysaccharide|identical protein binding|positive regulation of blood pressure|formaldehyde catabolic process|response to nitrosative stress|response to redox state|S-(hydroxymethyl)glutathione dehydrogenase activity|extracellular exosome|S-(hydroxymethyl)glutathione dehydrogenase NADP activity|S-(hydroxymethyl)glutathione dehydrogenase NAD activity","WP1589,WP3925","Folate-alcohol and cancer pathway hypotheses|Amino acid metabolism","R-HSA-1430728,R-HSA-211859,R-HSA-211945,R-HSA-71384","Metabolism|Biological oxidations|Phase I - Functionalization of compounds|Ethanol oxidation"]
["ADH6",0,0,0,0.00742250338385954,0,0,0,0.0151783982888531,0,0,0,0,0,0,0,0.0146761910692775,0,0,0,0,0,0,0,0.0151222993153457,0,0,0,0,130,"alcohol dehydrogenase 6 (class V)","protein_coding","hsa00010,hsa00620,hsa00071,hsa00350,hsa00830,hsa00980,hsa00982,hsa04936","Glycolysis / Gluconeogenesis|Pyruvate metabolism|Fatty acid degradation|Tyrosine metabolism|Retinol metabolism|Metabolism of xenobiotics by cytochrome P450|Drug metabolism - cytochrome P450|Alcoholic liver disease","GO:0004022,GO:0004024,GO:0004745,GO:0005829,GO:0006069,GO:0008270,GO:0042572,GO:0042573,GO:0045471,GO:0070062","alcohol dehydrogenase (NAD+) activity|alcohol dehydrogenase activity, zinc-dependent|NAD-retinol dehydrogenase activity|cytosol|ethanol oxidation|zinc ion binding|retinol metabolic process|retinoic acid metabolic process|response to ethanol|extracellular exosome","WP206","Fatty acid omega-oxidation","R-HSA-1430728,R-HSA-211859,R-HSA-211945,R-HSA-71384","Metabolism|Biological oxidations|Phase I - Functionalization of compounds|Ethanol oxidation"]
["ADHFE1",2.24179477615612,2.80841984836494,2.13034397028138,2.84483250763603,2.83173504559918,2.5929404072227,1.74722973497608,2.58702021281303,2.36493880803607,2.15913570815871,1.85117126283312,1.91161598284651,1.7549398712814,2.78888566015802,1.93230611836346,2.12556198100004,1.708509052714,2.11219741747515,1.62973765878224,1.74826667162298,1.36760802332964,1.76709490370934,1.29549949483373,1.82959500167414,1.58561210575007,2.078154401118,1.60055231328002,1.18228216819807,137872,"alcohol dehydrogenase iron containing 1","protein_coding",null,null,"GO:0004022,GO:0005739,GO:0005759,GO:0006103,GO:0006539,GO:0006629,GO:0046872,GO:0047988","alcohol dehydrogenase (NAD+) activity|mitochondrion|mitochondrial matrix|2-oxoglutarate metabolic process|glutamate catabolic process via 2-oxoglutarate|lipid metabolic process|metal ion binding|hydroxyacid-oxoacid transhydrogenase activity","WP4157,WP4519","GABA metabolism (aka GHB)|Cerebral organic acidurias, including diseases","R-HSA-1428517,R-HSA-1430728,R-HSA-71406,R-HSA-880009","The citric acid (TCA) cycle and respiratory electron transport|Metabolism|Pyruvate metabolism and Citric Acid (TCA) cycle|Interconversion of 2-oxoglutarate and 2-hydroxyglutarate"]
["ADI1",19.2078167141968,17.9944464006835,19.7379406409741,20.1832868551765,18.3884420587533,18.2447260270873,20.2093069025769,19.5009873818595,18.1873882243326,16.6744723575238,18.8311460083853,17.6564578894211,17.7358398936975,18.1466930186159,17.5106963062074,16.8244475541168,25.5270803077012,25.7160400491788,29.0973828211729,25.805245988571,25.1048255429853,26.5285079285824,26.7572232080092,25.8057918385102,23.338074441916,27.6289024678066,28.2294982653346,28.5140364705139,55256,"acireductone dioxygenase 1","protein_coding","hsa00270","Cysteine and methionine metabolism","GO:0005506,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0006555,GO:0010308,GO:0010309,GO:0016151,GO:0016491,GO:0019509","iron ion binding|protein binding|nucleus|cytoplasm|cytosol|plasma membrane|methionine metabolic process|acireductone dioxygenase (Ni2+-requiring) activity|acireductone dioxygenase [iron(II)-requiring] activity|nickel cation binding|oxidoreductase activity|L-methionine salvage from methylthioadenosine","WP3580","Methionine de novo and salvage pathway","R-HSA-1237112,R-HSA-1430728,R-HSA-1614635,R-HSA-71291","Methionine salvage pathway|Metabolism|Sulfur amino acid metabolism|Metabolism of amino acids and derivatives"]
["ADIPOR1",34.738185088782,32.0367044360236,28.2525907744139,31.3313414948129,31.7182817645222,28.083351132263,26.6389769545297,29.4661425449993,30.3361280890281,31.0720592076637,28.4562044842956,29.3017674995421,28.6602544495714,28.8790891191152,26.7172019909503,27.6875992814131,34.2875984556476,32.0707282810408,30.8545009582733,34.2623275237031,33.8058179834961,33.0931633794501,28.7089265179309,32.4650171392076,32.9233885027226,32.8297268874943,30.2390415056126,32.8855667113995,51094,"adiponectin receptor 1","protein_coding","hsa04152,hsa04920,hsa04211,hsa04936,hsa04932","AMPK signaling pathway|Adipocytokine signaling pathway|Longevity regulating pathway|Alcoholic liver disease|Non-alcoholic fatty liver disease","GO:0005515,GO:0005886,GO:0009755,GO:0010633,GO:0010719,GO:0010906,GO:0016020,GO:0019216,GO:0019395,GO:0019901,GO:0030308,GO:0033210,GO:0033211,GO:0038023,GO:0042593,GO:0042802,GO:0046426,GO:0046427,GO:0046628,GO:0046872,GO:0055100,GO:0097003,GO:0120162,GO:1901223","protein binding|plasma membrane|hormone-mediated signaling pathway|negative regulation of epithelial cell migration|negative regulation of epithelial to mesenchymal transition|regulation of glucose metabolic process|membrane|regulation of lipid metabolic process|fatty acid oxidation|protein kinase binding|negative regulation of cell growth|leptin-mediated signaling pathway|adiponectin-activated signaling pathway|signaling receptor activity|glucose homeostasis|identical protein binding|negative regulation of receptor signaling pathway via JAK-STAT|positive regulation of receptor signaling pathway via JAK-STAT|positive regulation of insulin receptor signaling pathway|metal ion binding|adiponectin binding|adipokinetic hormone receptor activity|positive regulation of cold-induced thermogenesis|negative regulation of non-canonical NF-kappaB signal transduction","WP3934,WP1403,WP4396","Leptin and adiponectin|AMP-activated protein kinase signaling|Nonalcoholic fatty liver disease","R-HSA-1430728,R-HSA-1430728,R-HSA-163680,R-HSA-163680,R-HSA-163685,R-HSA-163685","Metabolism|Metabolism|AMPK inhibits chREBP transcriptional activation activity|AMPK inhibits chREBP transcriptional activation activity|Integration of energy metabolism|Integration of energy metabolism"]
["ADIPOR2",21.5859834517891,20.8492636093712,20.8806848791481,20.0502695379366,21.1834937418409,21.0653675231258,20.1337619429009,20.5126814302677,22.0668866152945,19.8734725951632,20.585144213834,22.7369424433381,21.1627861423185,22.3706592356616,24.0748700053301,23.226556136105,23.843188985087,24.3755609123619,24.5251278579827,25.8384716929246,22.1296400852364,23.6080557224011,21.7310734362553,24.0533171211773,23.7657826026236,22.1429566803169,21.5999872156205,21.6818430565914,79602,"adiponectin receptor 2","protein_coding","hsa04152,hsa04920,hsa04211,hsa04936,hsa04932","AMPK signaling pathway|Adipocytokine signaling pathway|Longevity regulating pathway|Alcoholic liver disease|Non-alcoholic fatty liver disease","GO:0005515,GO:0005886,GO:0009755,GO:0019395,GO:0033211,GO:0038023,GO:0042593,GO:0042802,GO:0046872,GO:0055100,GO:0061042,GO:0097003,GO:0120162","protein binding|plasma membrane|hormone-mediated signaling pathway|fatty acid oxidation|adiponectin-activated signaling pathway|signaling receptor activity|glucose homeostasis|identical protein binding|metal ion binding|adiponectin binding|vascular wound healing|adipokinetic hormone receptor activity|positive regulation of cold-induced thermogenesis","WP3934,WP1403,WP4396","Leptin and adiponectin|AMP-activated protein kinase signaling|Nonalcoholic fatty liver disease","R-HSA-1430728,R-HSA-1430728,R-HSA-163680,R-HSA-163680,R-HSA-163685,R-HSA-163685","Metabolism|Metabolism|AMPK inhibits chREBP transcriptional activation activity|AMPK inhibits chREBP transcriptional activation activity|Integration of energy metabolism|Integration of energy metabolism"]
["ADIRF",36.3285516328236,41.9969833376307,53.7228530370725,51.5814620203579,44.3209013644434,49.3346148268412,65.5421776629205,60.9607323390346,23.5250053338084,23.3950463231442,27.7766722567878,24.5682124071742,26.4937142673066,31.1098617811429,23.8696495031836,27.596751559519,35.8370620984222,37.0345512712374,47.8005603616539,32.2883937775066,36.5205789745335,37.0244429825034,39.2597127280406,42.0443696043576,34.3972716031993,38.7262581149967,49.1330552159946,42.8832869125491,10974,"adipogenesis regulatory factor","protein_coding",null,null,"GO:0003674,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0030154,GO:0045600,GO:0045944,GO:0070062","molecular_function|protein binding|nucleus|nucleoplasm|cytosol|cell differentiation|positive regulation of fat cell differentiation|positive regulation of transcription by RNA polymerase II|extracellular exosome","WP5402","10q22q23 copy number variation","R-HSA-1266738,R-HSA-381340","Developmental Biology|Transcriptional regulation of white adipocyte differentiation"]
["ADIRF-AS1",6.9282713023627,4.29572025659345,6.02037995216308,8.16817068461782,7.76966916145878,5.85774293822401,5.32330610683321,7.1363878563817,3.42170566388474,3.99727950690468,3.6293593259591,4.76130495881373,3.29831710540095,4.60702901951943,2.83874436335131,3.48562028455382,4.76593452107232,3.77087377954592,5.85748036732935,3.93503880777709,3.2971062659514,4.31659683821871,7.71830165452856,5.31422607359431,4.44454938224354,6.02199900686823,6.17316303021348,5.38741478136132,100133190,"ADIRF antisense RNA 1","non_coding"]
["ADK",11.6752640883748,10.0362974575501,10.2945598759931,9.26690027085731,10.2140244257699,10.5346296581702,10.1671055885777,9.4508004919558,7.62628457819018,5.39344877288403,6.05027348160632,6.35454801604834,7.7386830893402,5.69202225203588,7.72285364476119,7.27652847611168,12.5962853621378,11.0026550697752,14.9275628921124,12.0583848381559,14.2656106748347,12.2421712213688,16.9081328269937,15.6167129507832,13.7359000802194,11.9501136849126,18.144812060798,13.3268765568335,132,"adenosine kinase","protein_coding","hsa00230","Purine metabolism","GO:0003723,GO:0004001,GO:0004136,GO:0005524,GO:0005634,GO:0005654,GO:0005829,GO:0005886,GO:0006144,GO:0006166,GO:0006175,GO:0009156,GO:0016310,GO:0032263,GO:0044209,GO:0046872,GO:0106383","RNA binding|adenosine kinase activity|deoxyadenosine kinase activity|ATP binding|nucleus|nucleoplasm|cytosol|plasma membrane|purine nucleobase metabolic process|purine ribonucleoside salvage|dATP biosynthetic process|ribonucleoside monophosphate biosynthetic process|phosphorylation|GMP salvage|AMP salvage|metal ion binding|dAMP salvage","WP4292","Methionine metabolism leading to sulfur amino acids and related disorders","R-HSA-1430728,R-HSA-15869,R-HSA-74217,R-HSA-8956321,R-HSA-9748784,R-HSA-9755088","Metabolism|Metabolism of nucleotides|Purine salvage|Nucleotide salvage|Drug ADME|Ribavirin ADME"]
["ADM",254.963880294739,271.985011958289,292.986428494855,294.497612295283,271.155103352741,305.727172857344,294.415715420216,300.455971940497,206.228591521315,219.739813987702,238.555428086411,219.597213253669,213.018926629021,246.194539990664,217.103365073366,230.883801727912,238.739987034587,283.084231691407,269.222859163398,257.392436349586,241.961156098208,274.896365813199,207.649886159383,225.475520045264,229.043432646812,278.552709837175,223.156420252723,268.740288884437,133,"adrenomedullin","protein_coding","hsa04080,hsa04270","Neuroactive ligand-receptor interaction|Vascular smooth muscle contraction","GO:0001570,GO:0001666,GO:0001843,GO:0002026,GO:0002031,GO:0003073,GO:0005102,GO:0005179,GO:0005576,GO:0005615,GO:0005737,GO:0006954,GO:0007165,GO:0007189,GO:0007204,GO:0007507,GO:0007565,GO:0008209,GO:0008284,GO:0008285,GO:0010460,GO:0019933,GO:0031100,GO:0031102,GO:0031623,GO:0031700,GO:0032496,GO:0032868,GO:0035809,GO:0042475,GO:0042594,GO:0043065,GO:0043116,GO:0045766,GO:0045906,GO:0048589,GO:0051384,GO:0060670,GO:0097084,GO:0097647,GO:1990410,GO:2000184,GO:2001214","vasculogenesis|response to hypoxia|neural tube closure|regulation of the force of heart contraction|G protein-coupled receptor internalization|regulation of systemic arterial blood pressure|signaling receptor binding|hormone activity|extracellular region|extracellular space|cytoplasm|inflammatory response|signal transduction|adenylate cyclase-activating G protein-coupled receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|heart development|female pregnancy|androgen metabolic process|positive regulation of cell population proliferation|negative regulation of cell population proliferation|positive regulation of heart rate|cAMP-mediated signaling|animal organ regeneration|neuron projection regeneration|receptor internalization|adrenomedullin receptor binding|response to lipopolysaccharide|response to insulin|regulation of urine volume|odontogenesis of dentin-containing tooth|response to starvation|positive regulation of apoptotic process|negative regulation of vascular permeability|positive regulation of angiogenesis|negative regulation of vasoconstriction|developmental growth|response to glucocorticoid|branching involved in labyrinthine layer morphogenesis|vascular associated smooth muscle cell development|amylin receptor signaling pathway|adrenomedullin receptor signaling pathway|positive regulation of progesterone biosynthetic process|positive regulation of vasculogenesis","WP2806,WP289","Complement system|Myometrial relaxation and contraction pathways","R-HSA-162582,R-HSA-372790,R-HSA-373080,R-HSA-388396,R-HSA-418555,R-HSA-419812,R-HSA-500792","Signal Transduction|Signaling by GPCR|Class B/2 (Secretin family receptors)|GPCR downstream signalling|G alpha (s) signalling events|Calcitonin-like ligand receptors|GPCR ligand binding"]
["ADM-DT",0.206802184926815,0.222360126605032,0.09285592283077,0.172465505576936,0.166934322077155,0.092877204131921,0.109055627074611,0.114620196150931,0.126617804529104,0.0779388302535042,0.0930148039280266,0.108553137626715,0.0940581515771902,0.0685775878228054,0.217410728425818,0.110827761078355,0.0950915440331302,0.0665554011218818,0.108030559444129,0.164280085601855,0.152757858686007,0.0940132211946764,0.319553661250683,0.245961827623378,0.0802285388345859,0.0854344662901249,0.269725172195883,0.22822980452018,105376544,null,"non_coding"]
["ADM2",0.465412955531495,0.885369877016037,1.02741436933179,0.826365693462352,0.848106877557888,0.897717100371184,0.950603049913654,0.918932317402155,0.809759729038341,1.38110177287295,0.6506261833323,0.651745169939024,1.2919240041687,1.4150887644976,1.21075823172821,1.17476471982919,0.477700578456171,0.512100797526229,0.186008466758175,0.532222773090156,0.700474816199989,0.490218348229213,0.155224677961442,0.466984788516861,0.530010850604488,0.52589040211213,0.115635943421356,0.331112886238434,79924,"adrenomedullin 2","protein_coding","hsa04080,hsa04270","Neuroactive ligand-receptor interaction|Vascular smooth muscle contraction","GO:0001525,GO:0003073,GO:0005179,GO:0005576,GO:0006468,GO:0007189,GO:0007631,GO:0010460,GO:0010628,GO:0044877,GO:0045766,GO:0045776","angiogenesis|regulation of systemic arterial blood pressure|hormone activity|extracellular region|protein phosphorylation|adenylate cyclase-activating G protein-coupled receptor signaling pathway|feeding behavior|positive regulation of heart rate|positive regulation of gene expression|protein-containing complex binding|positive regulation of angiogenesis|negative regulation of blood pressure",null,null,"R-HSA-162582,R-HSA-372790,R-HSA-373080,R-HSA-388396,R-HSA-418555,R-HSA-419812,R-HSA-500792","Signal Transduction|Signaling by GPCR|Class B/2 (Secretin family receptors)|GPCR downstream signalling|G alpha (s) signalling events|Calcitonin-like ligand receptors|GPCR ligand binding"]
["ADM5",0.273667159748661,0.16268929606645,0.481740984044731,0.623348992936133,0.0334270035791686,0.0321234261637631,0.15958061790789,0.100633936370702,0.137636032624457,0.263576551720254,0.386052213441934,0.240915413095838,0.195191281791704,0.260908132351232,0.318136159615679,0.194608528531575,0.131557198436236,0.221562761412406,0.379393538321164,0.164477590380163,0,0.292647062099072,0.202627300429261,0.26736532241294,0.101744991296991,0.0975123844940842,0.0993085065797352,0.192959095869008,199800,"adrenomedullin 5 (putative)","protein_coding",null,null,"GO:0003073,GO:0003674,GO:0005575,GO:0005576,GO:0007189,GO:0008150,GO:0010460","regulation of systemic arterial blood pressure|molecular_function|cellular_component|extracellular region|adenylate cyclase-activating G protein-coupled receptor signaling pathway|biological_process|positive regulation of heart rate"]
["ADNP",12.9065156499279,14.9047552715603,12.8529668305789,12.1166323788343,13.3957727594762,12.9257342106806,12.7180305346566,11.6201489336449,14.4998081348024,13.0035238847364,13.1633999297069,13.8172407882186,14.4512437440981,14.133073578912,15.5353115279441,14.8751503605967,12.1765024663653,12.2515291003329,12.4095101801146,14.6753405090816,12.9508775443993,12.8806413145566,14.1392915716386,13.7594657436373,12.3105241923631,11.8484476841699,13.3018385944564,11.6763501529903,23394,"activity dependent neuroprotector homeobox","protein_coding",null,null,"GO:0000785,GO:0000977,GO:0000981,GO:0001933,GO:0003682,GO:0005507,GO:0005515,GO:0005615,GO:0005634,GO:0006357,GO:0007614,GO:0008013,GO:0009743,GO:0010035,GO:0010468,GO:0010629,GO:0010976,GO:0019934,GO:0030182,GO:0030424,GO:0030425,GO:0031668,GO:0033484,GO:0042277,GO:0043025,GO:0043524,GO:0044849,GO:0045773,GO:0048487,GO:0050731,GO:0050805,GO:0051402,GO:0051965,GO:0090263,GO:0090575","chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|negative regulation of protein phosphorylation|chromatin binding|copper ion binding|protein binding|extracellular space|nucleus|regulation of transcription by RNA polymerase II|short-term memory|beta-catenin binding|response to carbohydrate|response to inorganic substance|regulation of gene expression|negative regulation of gene expression|positive regulation of neuron projection development|cGMP-mediated signaling|neuron differentiation|axon|dendrite|cellular response to extracellular stimulus|intracellular nitric oxide homeostasis|peptide binding|neuronal cell body|negative regulation of neuron apoptotic process|estrous cycle|positive regulation of axon extension|beta-tubulin binding|positive regulation of peptidyl-tyrosine phosphorylation|negative regulation of synaptic transmission|neuron apoptotic process|positive regulation of synapse assembly|positive regulation of canonical Wnt signaling pathway|RNA polymerase II transcription regulator complex"]
["ADNP-AS1",0.784370957378558,0.696329122872969,0.7363955294418,0.802407892484431,1.22632685099754,0.662907871057444,1.07332282911782,0.897343667993524,0.973064056061758,0.654723131867674,0.737655538778478,0.946970824262538,0.646472515575242,0.772728401682334,0.705145249227691,0.743702815144914,1.23173776576623,0.943476068134416,0.700767954875141,0.879979038348188,0.715652211977522,0.820130854922328,0.800158372920465,0.715221686920357,0.95909374919337,0.720450375188753,1.34093775260137,0.835719381914397,101927631,"ADNP antisense RNA 1","non_coding"]
["ADNP2",4.81501941244459,4.83796996429992,4.51124922091434,3.67632761808356,5.28352210599227,4.79024719085375,4.62585192335191,3.76856656350832,4.42641914291732,4.25260795356485,3.9390184757689,4.08490450121745,4.40075844279672,4.08256286598931,4.38618003021523,4.17712627474417,3.61905088838747,4.13107267500637,3.63853956718624,4.54483129166716,4.40497178585341,4.51120183232826,4.31515059437825,4.27999817364843,4.66611766090142,4.22356166680001,4.02924030551474,3.75676951291088,22850,"ADNP homeobox 2","protein_coding",null,null,"GO:0000785,GO:0000981,GO:0003674,GO:0003677,GO:0005515,GO:0005575,GO:0005634,GO:0006357,GO:0007399,GO:0010468,GO:0046872","chromatin|DNA-binding transcription factor activity, RNA polymerase II-specific|molecular_function|DNA binding|protein binding|cellular_component|nucleus|regulation of transcription by RNA polymerase II|nervous system development|regulation of gene expression|metal ion binding"]
["ADO",8.23024869416465,7.20097439133952,6.54224755949087,6.29812835796814,7.68497480477717,6.92748519993077,6.37443080566918,6.41848242183365,6.61992711595816,6.04175639664613,5.42074804810648,6.14532015131578,8.22914677183506,5.65934719635685,6.41396342057508,7.59960105939102,7.22360982988075,7.01151857844134,8.01075329809988,8.54863527192901,9.43950124372351,7.81634013059625,10.0218600548481,8.2088264760624,7.79005835493479,7.80659253480618,9.11588701993515,7.15775607857068,84890,"2-aminoethanethiol dioxygenase","protein_coding","hsa00430","Taurine and hypotaurine metabolism","GO:0005506,GO:0005515,GO:0005829,GO:0047800,GO:0071456","iron ion binding|protein binding|cytosol|cysteamine dioxygenase activity|cellular response to hypoxia",null,null,"R-HSA-1430728,R-HSA-1614558,R-HSA-1614635,R-HSA-71291","Metabolism|Degradation of cysteine and homocysteine|Sulfur amino acid metabolism|Metabolism of amino acids and derivatives"]
["ADORA1",0,0.0160148863585712,0.00790364137887254,0,8.22625821998277E-3,0.00790545278483615,0.0471266184552469,0,0.00846792580481518,0.00810814814005155,0.0158343298038853,0.0169395329275917,0,0.0160521243201726,0.0234876290234686,0.0239462086950158,0.00809393132165477,0,0.00778060868720272,0.0242863849880516,0.00794586821328076,0.00800214744028278,0,0,0,0,0.00814648169735909,0.03957208191359,134,"adenosine A1 receptor","protein_coding","hsa04071,hsa04024,hsa04022,hsa04080,hsa04923,hsa04924,hsa05032","Sphingolipid signaling pathway|cAMP signaling pathway|cGMP-PKG signaling pathway|Neuroactive ligand-receptor interaction|Regulation of lipolysis in adipocytes|Renin secretion|Morphine addiction","GO:0001609,GO:0001659,GO:0001664,GO:0001666,GO:0001883,GO:0001973,GO:0002087,GO:0002674,GO:0002686,GO:0002793,GO:0003084,GO:0003085,GO:0003093,GO:0005515,GO:0005886,GO:0006612,GO:0006909,GO:0006954,GO:0007165,GO:0007186,GO:0007193,GO:0007267,GO:0007399,GO:0008285,GO:0010035,GO:0014050,GO:0014074,GO:0016042,GO:0016323,GO:0030425,GO:0030673,GO:0031072,GO:0031683,GO:0032229,GO:0032244,GO:0032279,GO:0032795,GO:0032900,GO:0035307,GO:0042311,GO:0042323,GO:0042734,GO:0043025,GO:0043066,GO:0043195,GO:0043197,GO:0043268,GO:0043410,GO:0044305,GO:0045202,GO:0045211,GO:0046888,GO:0046982,GO:0048786,GO:0050890,GO:0050900,GO:0050965,GO:0050995,GO:0050996,GO:0051930,GO:0051967,GO:0055089,GO:0060079,GO:0060292,GO:0070254,GO:0070256,GO:0070328,GO:0086004,GO:0097190,GO:0099509,GO:1900272,GO:1900453","G protein-coupled adenosine receptor activity|temperature homeostasis|G protein-coupled receptor binding|response to hypoxia|purine nucleoside binding|G protein-coupled adenosine receptor signaling pathway|regulation of respiratory gaseous exchange by nervous system process|negative regulation of acute inflammatory response|negative regulation of leukocyte migration|positive regulation of peptide secretion|positive regulation of systemic arterial blood pressure|negative regulation of systemic arterial blood pressure|regulation of glomerular filtration|protein binding|plasma membrane|protein targeting to membrane|phagocytosis|inflammatory response|signal transduction|G protein-coupled receptor signaling pathway|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway|cell-cell signaling|nervous system development|negative regulation of cell population proliferation|response to inorganic substance|negative regulation of glutamate secretion|response to purine-containing compound|lipid catabolic process|basolateral plasma membrane|dendrite|axolemma|heat shock protein binding|G-protein beta/gamma-subunit complex binding|negative regulation of synaptic transmission, GABAergic|positive regulation of nucleoside transport|asymmetric synapse|heterotrimeric G-protein binding|negative regulation of neurotrophin production|positive regulation of protein dephosphorylation|vasodilation|negative regulation of circadian sleep/wake cycle, non-REM sleep|presynaptic membrane|neuronal cell body|negative regulation of apoptotic process|terminal bouton|dendritic spine|positive regulation of potassium ion transport|positive regulation of MAPK cascade|calyx of Held|synapse|postsynaptic membrane|negative regulation of hormone secretion|protein heterodimerization activity|presynaptic active zone|cognition|leukocyte migration|detection of temperature stimulus involved in sensory perception of pain|negative regulation of lipid catabolic process|positive regulation of lipid catabolic process|regulation of sensory perception of pain|negative regulation of synaptic transmission, glutamatergic|fatty acid homeostasis|excitatory postsynaptic potential|long-term synaptic depression|mucus secretion|negative regulation of mucus secretion|triglyceride homeostasis|regulation of cardiac muscle cell contraction|apoptotic signaling pathway|regulation of presynaptic cytosolic calcium ion concentration|negative regulation of long-term synaptic potentiation|negative regulation of long-term synaptic depression","WP80,WP4900,WP455,WP3591,WP3594","Nucleotide GPCRs|Purinergic signaling|GPCRs, class A rhodopsin-like|Sleep regulation|Circadian rhythm genes","R-HSA-162582,R-HSA-372790,R-HSA-373076,R-HSA-388396,R-HSA-417973,R-HSA-418038,R-HSA-418594,R-HSA-500792","Signal Transduction|Signaling by GPCR|Class A/1 (Rhodopsin-like receptors)|GPCR downstream signalling|Adenosine P1 receptors|Nucleotide-like (purinergic) receptors|G alpha (i) signalling events|GPCR ligand binding"]
["ADORA2A",0,0.0091964967934263,0.027231843287464,0.00927280462194504,0,0,0,0,0,0,0.00909281277475622,0,0,0,0,0,0,0,0,0.0836782690800659,0,0.00919041467137211,0,0,0.038342923549512,0.0091869630537229,0,0.00908965611817182,135,"adenosine A2a receptor","protein_coding","hsa04015,hsa04020,hsa04024,hsa04080,hsa04270,hsa05012,hsa05034","Rap1 signaling pathway|Calcium signaling pathway|cAMP signaling pathway|Neuroactive ligand-receptor interaction|Vascular smooth muscle contraction|Parkinson disease|Alcoholism","GO:0001609,GO:0001963,GO:0001973,GO:0001975,GO:0005515,GO:0005516,GO:0005882,GO:0005886,GO:0006355,GO:0006909,GO:0006915,GO:0006954,GO:0006968,GO:0007188,GO:0007189,GO:0007205,GO:0007267,GO:0007271,GO:0007417,GO:0007596,GO:0007600,GO:0007626,GO:0008015,GO:0008285,GO:0008289,GO:0009410,GO:0010035,GO:0014049,GO:0014057,GO:0014061,GO:0014074,GO:0016020,GO:0019899,GO:0030425,GO:0030673,GO:0031000,GO:0031802,GO:0032230,GO:0032279,GO:0035249,GO:0035810,GO:0042311,GO:0042734,GO:0042755,GO:0042802,GO:0043025,GO:0043116,GO:0043524,GO:0044877,GO:0045211,GO:0045938,GO:0046636,GO:0048143,GO:0048786,GO:0048812,GO:0050714,GO:0050728,GO:0051393,GO:0051881,GO:0051899,GO:0051924,GO:0051968,GO:0060079,GO:0060080,GO:0060134,GO:0097190,GO:0098978,GO:0099171,GO:1900273,GO:2001235","G protein-coupled adenosine receptor activity|synaptic transmission, dopaminergic|G protein-coupled adenosine receptor signaling pathway|response to amphetamine|protein binding|calmodulin binding|intermediate filament|plasma membrane|regulation of DNA-templated transcription|phagocytosis|apoptotic process|inflammatory response|cellular defense response|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|adenylate cyclase-activating G protein-coupled receptor signaling pathway|protein kinase C-activating G protein-coupled receptor signaling pathway|cell-cell signaling|synaptic transmission, cholinergic|central nervous system development|blood coagulation|sensory perception|locomotory behavior|blood circulation|negative regulation of cell population proliferation|lipid binding|response to xenobiotic stimulus|response to inorganic substance|positive regulation of glutamate secretion|positive regulation of acetylcholine secretion, neurotransmission|regulation of norepinephrine secretion|response to purine-containing compound|membrane|enzyme binding|dendrite|axolemma|response to caffeine|type 5 metabotropic glutamate receptor binding|positive regulation of synaptic transmission, GABAergic|asymmetric synapse|synaptic transmission, glutamatergic|positive regulation of urine volume|vasodilation|presynaptic membrane|eating behavior|identical protein binding|neuronal cell body|negative regulation of vascular permeability|negative regulation of neuron apoptotic process|protein-containing complex binding|postsynaptic membrane|positive regulation of circadian sleep/wake cycle, sleep|negative regulation of alpha-beta T cell activation|astrocyte activation|presynaptic active zone|neuron projection morphogenesis|positive regulation of protein secretion|negative regulation of inflammatory response|alpha-actinin binding|regulation of mitochondrial membrane potential|membrane depolarization|regulation of calcium ion transport|positive regulation of synaptic transmission, glutamatergic|excitatory postsynaptic potential|inhibitory postsynaptic potential|prepulse inhibition|apoptotic signaling pathway|glutamatergic synapse|presynaptic modulation of chemical synaptic transmission|positive regulation of long-term synaptic potentiation|positive regulation of apoptotic signaling pathway","WP80,WP4900,WP4222,WP3869,WP455,WP3591,WP3594,WP727,WP117","Nucleotide GPCRs|Purinergic signaling|Phosphodiesterases in neuronal function|Cannabinoid receptor signaling|GPCRs, class A rhodopsin-like|Sleep regulation|Circadian rhythm genes|Monoamine transport|GPCRs, other","R-HSA-162582,R-HSA-162582,R-HSA-166520,R-HSA-187015,R-HSA-187024,R-HSA-187037,R-HSA-372790,R-HSA-373076,R-HSA-388396,R-HSA-392499,R-HSA-417973,R-HSA-418038,R-HSA-418555,R-HSA-500792,R-HSA-5683826,R-HSA-9006934","Signal Transduction|Signal Transduction|Signaling by NTRKs|Activation of TRKA receptors|NGF-independant TRKA activation|Signaling by NTRK1 (TRKA)|Signaling by GPCR|Class A/1 (Rhodopsin-like receptors)|GPCR downstream signalling|Metabolism of proteins|Adenosine P1 receptors|Nucleotide-like (purinergic) receptors|G alpha (s) signalling events|GPCR ligand binding|Surfactant metabolism|Signaling by Receptor Tyrosine Kinases"]
["ADORA2A-AS1",0,0,0.00628913014292989,0,0,0,0,0.00656888186382649,0,0,0,0.00673961039191708,0,0,0,0,0,0,0,0,0.00632273111802311,0,0.00661325019624991,0.0130892068875122,0,0,0,0,646023,"ADORA2A antisense RNA 1","non_coding"]
["ADORA2B",1.02694769298202,0.800001686583887,0.968497854218802,0.686312223761652,0.844566292120597,0.824720928360899,1.079525330148,0.956898453750723,0.556214706570447,0.434122076092255,0.511297906546178,0.495559450958435,0.37120327887021,0.420866720992355,0.475367045603983,0.356877353304412,0.330605212688063,0.438553168450848,0.395111675488868,0.353010134678363,0.438591105308136,0.410778741191526,0.357820042337072,0.476680890718123,0.267204107466397,0.441531684085148,0.485637599492144,0.353852587804603,136,"adenosine A2b receptor","protein_coding","hsa04015,hsa04020,hsa04080,hsa04270,hsa05034","Rap1 signaling pathway|Calcium signaling pathway|Neuroactive ligand-receptor interaction|Vascular smooth muscle contraction|Alcoholism","GO:0001609,GO:0001973,GO:0002882,GO:0004930,GO:0005515,GO:0005886,GO:0007186,GO:0007189,GO:0007190,GO:0010575,GO:0010753,GO:0019934,GO:0031668,GO:0032722,GO:0032755,GO:0042311,GO:0043303,GO:0043306,GO:0060087,GO:0098685,GO:0098793,GO:0098978,GO:0099171","G protein-coupled adenosine receptor activity|G protein-coupled adenosine receptor signaling pathway|positive regulation of chronic inflammatory response to non-antigenic stimulus|G protein-coupled receptor activity|protein binding|plasma membrane|G protein-coupled receptor signaling pathway|adenylate cyclase-activating G protein-coupled receptor signaling pathway|activation of adenylate cyclase activity|positive regulation of vascular endothelial growth factor production|positive regulation of cGMP-mediated signaling|cGMP-mediated signaling|cellular response to extracellular stimulus|positive regulation of chemokine production|positive regulation of interleukin-6 production|vasodilation|mast cell degranulation|positive regulation of mast cell degranulation|relaxation of vascular associated smooth muscle|Schaffer collateral - CA1 synapse|presynapse|glutamatergic synapse|presynaptic modulation of chemical synaptic transmission","WP80,WP4963,WP4900,WP455","Nucleotide GPCRs|p53 transcriptional gene network|Purinergic signaling|GPCRs, class A rhodopsin-like","R-HSA-162582,R-HSA-1643685,R-HSA-372790,R-HSA-373076,R-HSA-388396,R-HSA-392499,R-HSA-417973,R-HSA-418038,R-HSA-418555,R-HSA-500792,R-HSA-5663205,R-HSA-5683826,R-HSA-9658195,R-HSA-9660821,R-HSA-9662851,R-HSA-9664433,R-HSA-9824443","Signal Transduction|Disease|Signaling by GPCR|Class A/1 (Rhodopsin-like receptors)|GPCR downstream signalling|Metabolism of proteins|Adenosine P1 receptors|Nucleotide-like (purinergic) receptors|G alpha (s) signalling events|GPCR ligand binding|Infectious disease|Surfactant metabolism|Leishmania infection|ADORA2B mediated anti-inflammatory cytokines production|Anti-inflammatory response favouring Leishmania parasite infection|Leishmania parasite growth and survival|Parasitic Infection Pathways"]
["ADORA3",0,0,0.0277951232236681,0.113575307132269,0,0,0.0276220816938862,0.0435472497858942,0,0,0,0,0,0,0,0.01403546773594,0,0,0,0,0,0.0562830886409345,0,0,0,0,0,0,140,"adenosine A3 receptor","protein_coding","hsa04071,hsa04022,hsa04080","Sphingolipid signaling pathway|cGMP-PKG signaling pathway|Neuroactive ligand-receptor interaction","GO:0001609,GO:0001973,GO:0005886,GO:0006954,GO:0007165,GO:0007190,GO:0008016,GO:0008285,GO:0009611,GO:0014061,GO:0030336,GO:0030425,GO:0032088,GO:0042734,GO:0045202,GO:0098685,GO:0099171","G protein-coupled adenosine receptor activity|G protein-coupled adenosine receptor signaling pathway|plasma membrane|inflammatory response|signal transduction|activation of adenylate cyclase activity|regulation of heart contraction|negative regulation of cell population proliferation|response to wounding|regulation of norepinephrine secretion|negative regulation of cell migration|dendrite|negative regulation of NF-kappaB transcription factor activity|presynaptic membrane|synapse|Schaffer collateral - CA1 synapse|presynaptic modulation of chemical synaptic transmission","WP80,WP4900,WP455,WP117","Nucleotide GPCRs|Purinergic signaling|GPCRs, class A rhodopsin-like|GPCRs, other","R-HSA-162582,R-HSA-372790,R-HSA-373076,R-HSA-388396,R-HSA-417973,R-HSA-418038,R-HSA-418594,R-HSA-500792","Signal Transduction|Signaling by GPCR|Class A/1 (Rhodopsin-like receptors)|GPCR downstream signalling|Adenosine P1 receptors|Nucleotide-like (purinergic) receptors|G alpha (i) signalling events|GPCR ligand binding"]
["ADPGK",13.9837946568738,13.5512211100421,11.8156382458787,12.4759480053527,14.6022256247769,13.0200476892038,11.6506070109352,12.4272380556686,13.8633788473517,14.0297751995345,11.6611564173998,13.4614583497078,13.7597398885089,14.0058072552047,11.8819227295604,13.9437159703998,16.7585839614411,13.8888248053918,14.3452976878638,14.8712174056297,15.6922440277519,15.4110024345509,14.0801666797009,14.5087143364447,16.7747574816689,14.79724301976,15.1596792540293,14.6502149689009,83440,"ADP dependent glucokinase","protein_coding","hsa00010","Glycolysis / Gluconeogenesis","GO:0005576,GO:0005783,GO:0005789,GO:0006006,GO:0016020,GO:0016310,GO:0043843,GO:0046872,GO:0061620","extracellular region|endoplasmic reticulum|endoplasmic reticulum membrane|glucose metabolic process|membrane|phosphorylation|ADP-specific glucokinase activity|metal ion binding|glycolytic process through glucose-6-phosphate",null,null,"R-HSA-1430728,R-HSA-70171,R-HSA-70326,R-HSA-71387","Metabolism|Glycolysis|Glucose metabolism|Metabolism of carbohydrates"]
["ADPGK-AS1",0.167859215750598,0.0751350419342785,0.0463506587823258,0.142047138933971,0.0964852704043401,0.0834503070891605,0.0368496782157999,0.0290474512308108,0.109251751903736,0.0190199929263333,0.00928599341246167,0.059604818059504,0.065731081218745,0.0753097466273885,0.0459141563694423,0.112345436251195,0.0664532515177912,0.027408391835632,0.191642377049408,0.13293163202007,0,0.0563140134149131,0.1657139997894,0.106113672833121,0.166419524226435,0.0469107197688268,0.0573297459229534,0.0278483090741352,100287559,"ADPGK antisense RNA 1","non_coding"]
["ADPRH",1.66527289861404,1.85684121883449,1.65125026238599,1.90813808242214,2.03556685007138,1.73948129700658,1.69334161643787,1.92041154898007,1.46173797628302,1.33355586683637,1.67753769934794,1.48088046349596,1.42944570193194,1.64709577444173,1.62409908046282,1.67946289592543,1.49911893174101,1.5927560604899,1.37191465661932,1.55937846909245,1.65418562594121,1.65997346345671,1.1698812054708,1.57817918156819,1.41601782890056,1.85491628575959,1.29761277068785,1.49518744115064,141,"ADP-ribosylarginine hydrolase","protein_coding",null,null,"GO:0000287,GO:0003875,GO:0005515,GO:0005615,GO:0030955,GO:0036211,GO:0051725","magnesium ion binding|ADP-ribosylarginine hydrolase activity|protein binding|extracellular space|potassium ion binding|protein modification process|protein de-ADP-ribosylation"]
["ADPRHL1",0.142469929515127,0.191438350867991,0.131632760159336,0.112779708294555,0.099439727090379,0.131662928578591,0.111824243729951,0.0953545945185928,0.0773394418220318,0.0718754682354603,0.125477765012181,0.0705307012356799,0.0731203135034026,0.0603678380054276,0.0546809868977016,0.0600369487349088,0.126105079641983,0.0816043478394784,0.0710620223622807,0.108731829882188,0.0981848004086032,0.139722059290776,0.0959986499964359,0.0618618757730611,0.067260950622508,0.120330718762722,0.0984753815245361,0.0871661419090591,113622,"ADP-ribosylhydrolase like 1","protein_coding",null,null,"GO:0000287,GO:0003242,GO:0003875,GO:0030017,GO:0055003","magnesium ion binding|cardiac chamber ballooning|ADP-ribosylarginine hydrolase activity|sarcomere|cardiac myofibril assembly"]
["ADPRM",3.67265253205072,3.17572899701028,4.52036763785597,3.69081803365725,3.38270816663351,3.64682556686246,4.88570521767957,5.13499858198909,5.46174590218293,4.11267050436776,5.42050191737593,4.98558944277377,5.86566343418123,4.6238907992833,5.09880597512858,5.14837242820625,5.32189175290786,4.97531994168846,5.42445372326292,4.66387251324654,5.77187038238976,5.04439933725111,7.80656678968015,7.84570815238415,4.93036506718695,5.62690108142352,7.24395348907826,6.39331095608748,56985,"ADP-ribose/CDP-alcohol diphosphatase%2C manganese dependent","protein_coding","hsa00564,hsa00230","Glycerophospholipid metabolism|Purine metabolism","GO:0005829,GO:0008663,GO:0030145,GO:0047631,GO:0047734","cytosol|2',3'-cyclic-nucleotide 2'-phosphodiesterase activity|manganese ion binding|ADP-ribose diphosphatase activity|CDP-glycerol diphosphatase activity",null,null,"R-HSA-1430728,R-HSA-15869,R-HSA-2393930,R-HSA-74259,R-HSA-8956319","Metabolism|Metabolism of nucleotides|Phosphate bond hydrolysis by NUDT proteins|Purine catabolism|Nucleotide catabolism"]
["ADPRS",18.8108208849072,16.3921731264637,16.0575679127247,17.4325594944081,14.2028878561061,15.5726930116925,14.1980165487438,17.3138927342346,13.0665406774351,17.1620447632761,14.9994556922291,14.7868840556304,12.9103296736334,13.2372323192118,12.0356013176487,12.2860034001665,22.5560291656618,21.2861373625763,19.9247967163914,19.4959712304948,20.5628334290467,21.8984411574571,17.527139275249,20.2519556263782,19.3425942441567,24.6091146074129,18.9423289574863,25.0821220889607,54936,"ADP-ribosylserine hydrolase","protein_coding","hsa03410","Base excision repair","GO:0000287,GO:0004553,GO:0004649,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005759,GO:0006281,GO:0006287,GO:0016604,GO:0060546,GO:0061463,GO:0071451,GO:0090734,GO:0140290,GO:0140292","magnesium ion binding|hydrolase activity, hydrolyzing O-glycosyl compounds|poly(ADP-ribose) glycohydrolase activity|protein binding|nucleus|nucleoplasm|cytoplasm|mitochondrion|mitochondrial matrix|DNA repair|base-excision repair, gap-filling|nuclear body|negative regulation of necroptotic process|O-acetyl-ADP-ribose deacetylase activity|cellular response to superoxide|site of DNA damage|peptidyl-serine ADP-deribosylation|ADP-ribosylserine hydrolase activity",null,null,"R-HSA-110362,R-HSA-110373,R-HSA-73884,R-HSA-73894,R-HSA-73933","POLB-Dependent Long Patch Base Excision Repair|Resolution of AP sites via the multiple-nucleotide patch replacement pathway|Base Excision Repair|DNA Repair|Resolution of Abasic Sites (AP sites)"]
["ADRA1A",0,0,0,0,0,0,0,0,0,0.00361453347874352,8.82348752776456E-4,0.00566360910871345,0,0.00178897017413917,0.000872546356817219,0.000889582219454488,0,0,0,0,0,0,0,0,0,0,0,0,148,"adrenoceptor alpha 1A","protein_coding","hsa04020,hsa04022,hsa04152,hsa04080,hsa04261,hsa04270,hsa04970","Calcium signaling pathway|cGMP-PKG signaling pathway|AMPK signaling pathway|Neuroactive ligand-receptor interaction|Adrenergic signaling in cardiomyocytes|Vascular smooth muscle contraction|Salivary secretion","GO:0000165,GO:0001985,GO:0001994,GO:0001996,GO:0001997,GO:0004937,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0005901,GO:0006915,GO:0006939,GO:0007165,GO:0007186,GO:0007200,GO:0007202,GO:0007204,GO:0007267,GO:0007512,GO:0008285,GO:0009410,GO:0009725,GO:0010507,GO:0010613,GO:0031965,GO:0032230,GO:0035556,GO:0043231,GO:0043410,GO:0045760,GO:0045907,GO:0045987,GO:0046982,GO:0060402,GO:0060452,GO:0061049,GO:0070374,GO:0071880,GO:0090037,GO:0097195,GO:0150099","MAPK cascade|negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure|norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure|positive regulation of heart rate by epinephrine-norepinephrine|positive regulation of the force of heart contraction by epinephrine-norepinephrine|alpha1-adrenergic receptor activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|plasma membrane|caveola|apoptotic process|smooth muscle contraction|signal transduction|G protein-coupled receptor signaling pathway|phospholipase C-activating G protein-coupled receptor signaling pathway|activation of phospholipase C activity|positive regulation of cytosolic calcium ion concentration|cell-cell signaling|adult heart development|negative regulation of cell population proliferation|response to xenobiotic stimulus|response to hormone|negative regulation of autophagy|positive regulation of cardiac muscle hypertrophy|nuclear membrane|positive regulation of synaptic transmission, GABAergic|intracellular signal transduction|intracellular membrane-bounded organelle|positive regulation of MAPK cascade|positive regulation of action potential|positive regulation of vasoconstriction|positive regulation of smooth muscle contraction|protein heterodimerization activity|calcium ion transport into cytosol|positive regulation of cardiac muscle contraction|cell growth involved in cardiac muscle cell development|positive regulation of ERK1 and ERK2 cascade|adenylate cyclase-activating adrenergic receptor signaling pathway|positive regulation of protein kinase C signaling|pilomotor reflex|neuron-glial cell signaling","WP455,WP2197,WP1403,WP58,WP536,WP3947","GPCRs, class A rhodopsin-like|Endothelin pathways|AMP-activated protein kinase signaling|Monoamine GPCRs|Calcium regulation in cardiac cells|Serotonin and anxiety","R-HSA-162582,R-HSA-372790,R-HSA-373076,R-HSA-375280,R-HSA-388396,R-HSA-390696,R-HSA-416476,R-HSA-416482,R-HSA-500792","Signal Transduction|Signaling by GPCR|Class A/1 (Rhodopsin-like receptors)|Amine ligand-binding receptors|GPCR downstream signalling|Adrenoceptors|G alpha (q) signalling events|G alpha (12/13) signalling events|GPCR ligand binding"]
["ADRA1B",0.56390508792659,0.777486541309175,0.709123714709122,0.649973685148017,0.692571845003881,0.918185607028418,0.699882214841397,0.92329697204623,0.507368601215675,0.657714677183907,0.474368927466075,0.460634682124763,0.482149875094604,0.387181058703159,0.509994763273744,0.402227063288752,0.698840018600397,0.672545809067218,0.542689429683144,0.701459595507502,0.808130100399595,0.848276773419631,0.477534921185654,0.611571556506789,0.682166271176146,0.838126789260032,0.478096302603806,0.690635927177766,147,"adrenoceptor alpha 1B","protein_coding","hsa04020,hsa04022,hsa04080,hsa04261,hsa04270,hsa04970","Calcium signaling pathway|cGMP-PKG signaling pathway|Neuroactive ligand-receptor interaction|Adrenergic signaling in cardiomyocytes|Vascular smooth muscle contraction|Salivary secretion","GO:0001996,GO:0004937,GO:0005515,GO:0005634,GO:0005737,GO:0005886,GO:0005901,GO:0007186,GO:0007188,GO:0007200,GO:0007204,GO:0007267,GO:0019229,GO:0031965,GO:0035556,GO:0043410,GO:0046982,GO:0055117,GO:0071880,GO:0150099","positive regulation of heart rate by epinephrine-norepinephrine|alpha1-adrenergic receptor activity|protein binding|nucleus|cytoplasm|plasma membrane|caveola|G protein-coupled receptor signaling pathway|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|phospholipase C-activating G protein-coupled receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|cell-cell signaling|regulation of vasoconstriction|nuclear membrane|intracellular signal transduction|positive regulation of MAPK cascade|protein heterodimerization activity|regulation of cardiac muscle contraction|adenylate cyclase-activating adrenergic receptor signaling pathway|neuron-glial cell signaling","WP455,WP1403,WP58,WP536,WP2877","GPCRs, class A rhodopsin-like|AMP-activated protein kinase signaling|Monoamine GPCRs|Calcium regulation in cardiac cells|Vitamin D receptor pathway","R-HSA-162582,R-HSA-372790,R-HSA-373076,R-HSA-375280,R-HSA-388396,R-HSA-390696,R-HSA-416476,R-HSA-416482,R-HSA-500792","Signal Transduction|Signaling by GPCR|Class A/1 (Rhodopsin-like receptors)|Amine ligand-binding receptors|GPCR downstream signalling|Adrenoceptors|G alpha (q) signalling events|G alpha (12/13) signalling events|GPCR ligand binding"]
["ADRA1D",0.109950571999632,0.156871854208465,0.129031915508921,0.149386080170532,0.1522053500838,0.258122975700666,0.188068633042228,0.179695313528469,0.0921628090653236,0.0529482467935657,0.13786954189542,0.119837695044856,0.14812952701573,0.113559776844239,0.0937322988289839,0.0347499479906824,0.0176184691311615,0.076300043893211,0.0169364439268682,0.0176218003017768,0.051888518053552,0.0435466963014708,0.0180909033240718,0.0179031164226203,0.0181679250265192,0,0.00886642909413453,0.0258415648444558,146,"adrenoceptor alpha 1D","protein_coding","hsa04020,hsa04022,hsa04080,hsa04261,hsa04270,hsa04970","Calcium signaling pathway|cGMP-PKG signaling pathway|Neuroactive ligand-receptor interaction|Adrenergic signaling in cardiomyocytes|Vascular smooth muscle contraction|Salivary secretion","GO:0004937,GO:0005515,GO:0005886,GO:0007186,GO:0007188,GO:0007200,GO:0007204,GO:0007267,GO:0008284,GO:0042802,GO:0045907,GO:0071880,GO:0150099","alpha1-adrenergic receptor activity|protein binding|plasma membrane|G protein-coupled receptor signaling pathway|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|phospholipase C-activating G protein-coupled receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|cell-cell signaling|positive regulation of cell population proliferation|identical protein binding|positive regulation of vasoconstriction|adenylate cyclase-activating adrenergic receptor signaling pathway|neuron-glial cell signaling","WP4589,WP455,WP58,WP536,WP117","Major receptors targeted by epinephrine and norepinephrine|GPCRs, class A rhodopsin-like|Monoamine GPCRs|Calcium regulation in cardiac cells|GPCRs, other","R-HSA-162582,R-HSA-372790,R-HSA-373076,R-HSA-375280,R-HSA-388396,R-HSA-390696,R-HSA-416476,R-HSA-416482,R-HSA-500792","Signal Transduction|Signaling by GPCR|Class A/1 (Rhodopsin-like receptors)|Amine ligand-binding receptors|GPCR downstream signalling|Adrenoceptors|G alpha (q) signalling events|G alpha (12/13) signalling events|GPCR ligand binding"]
["ADRA2A",0.00694926920217662,0.00660990798145721,0.00652422265922915,0.00666475361845392,0,0,0,0.0272577268574764,0.0209700683890318,0.0401582217238129,0.0130707718566745,0.0629238798540008,0,0.00662527740051465,0.00646278148432985,0.01317792562369,0.0200439041700994,0.057869226381497,0.0128453256078489,0.0467779524896613,0.0524726373166796,0.0396332190313773,0.0411627514148641,0.00678924574830487,0.0137793337014745,0.0462213897799577,0.00672468017399943,0.00653311710684791,150,"adrenoceptor alpha 2A","protein_coding","hsa04022,hsa04080","cGMP-PKG signaling pathway|Neuroactive ligand-receptor interaction","GO:0001819,GO:0004938,GO:0005515,GO:0005737,GO:0005886,GO:0006260,GO:0007186,GO:0007189,GO:0007193,GO:0007265,GO:0007266,GO:0007565,GO:0008284,GO:0010700,GO:0016323,GO:0019229,GO:0019901,GO:0030036,GO:0030168,GO:0030335,GO:0031692,GO:0031696,GO:0031996,GO:0032147,GO:0032148,GO:0032795,GO:0032811,GO:0032870,GO:0035624,GO:0042311,GO:0042593,GO:0042596,GO:0042803,GO:0043025,GO:0043235,GO:0043268,GO:0043406,GO:0043410,GO:0043679,GO:0045741,GO:0045955,GO:0046676,GO:0046982,GO:0048787,GO:0050892,GO:0050955,GO:0050995,GO:0051044,GO:0051379,GO:0051380,GO:0051926,GO:0061179,GO:0070473,GO:0071875,GO:0071880,GO:0071881,GO:0071882,GO:0090303,GO:0098691,GO:0098839,GO:0098978,GO:0098982,GO:0099171,GO:1901020","positive regulation of cytokine production|alpha2-adrenergic receptor activity|protein binding|cytoplasm|plasma membrane|DNA replication|G protein-coupled receptor signaling pathway|adenylate cyclase-activating G protein-coupled receptor signaling pathway|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway|Ras protein signal transduction|Rho protein signal transduction|female pregnancy|positive regulation of cell population proliferation|negative regulation of norepinephrine secretion|basolateral plasma membrane|regulation of vasoconstriction|protein kinase binding|actin cytoskeleton organization|platelet activation|positive regulation of cell migration|alpha-1B adrenergic receptor binding|alpha-2C adrenergic receptor binding|thioesterase binding|activation of protein kinase activity|activation of protein kinase B activity|heterotrimeric G-protein binding|negative regulation of epinephrine secretion|cellular response to hormone stimulus|receptor transactivation|vasodilation|glucose homeostasis|fear response|protein homodimerization activity|neuronal cell body|receptor complex|positive regulation of potassium ion transport|positive regulation of MAP kinase activity|positive regulation of MAPK cascade|axon terminus|positive regulation of epidermal growth factor-activated receptor activity|negative regulation of calcium ion-dependent exocytosis|negative regulation of insulin secretion|protein heterodimerization activity|presynaptic active zone membrane|intestinal absorption|thermoception|negative regulation of lipid catabolic process|positive regulation of membrane protein ectodomain proteolysis|epinephrine binding|norepinephrine binding|negative regulation of calcium ion transport|negative regulation of insulin secretion involved in cellular response to glucose stimulus|negative regulation of uterine smooth muscle contraction|adrenergic receptor signaling pathway|adenylate cyclase-activating adrenergic receptor signaling pathway|adenylate cyclase-inhibiting adrenergic receptor signaling pathway|phospholipase C-activating adrenergic receptor signaling pathway|positive regulation of wound healing|dopaminergic synapse|postsynaptic density membrane|glutamatergic synapse|GABA-ergic synapse|presynaptic modulation of chemical synaptic transmission|negative regulation of calcium ion transmembrane transporter activity","WP4589,WP455,WP58","Major receptors targeted by epinephrine and norepinephrine|GPCRs, class A rhodopsin-like|Monoamine GPCRs","R-HSA-109582,R-HSA-1430728,R-HSA-162582,R-HSA-163685,R-HSA-372790,R-HSA-373076,R-HSA-375280,R-HSA-388396,R-HSA-390696,R-HSA-392023,R-HSA-392499,R-HSA-400042,R-HSA-418594,R-HSA-418597,R-HSA-422356,R-HSA-500792,R-HSA-5683826,R-HSA-76002,R-HSA-76009","Hemostasis|Metabolism|Signal Transduction|Integration of energy metabolism|Signaling by GPCR|Class A/1 (Rhodopsin-like receptors)|Amine ligand-binding receptors|GPCR downstream signalling|Adrenoceptors|Adrenaline signalling through Alpha-2 adrenergic receptor|Metabolism of proteins|Adrenaline,noradrenaline inhibits insulin secretion|G alpha (i) signalling events|G alpha (z) signalling events|Regulation of insulin secretion|GPCR ligand binding|Surfactant metabolism|Platelet activation, signaling and aggregation|Platelet Aggregation (Plug Formation)"]
["ADRA2C",0.0251692019003203,0.035910130336236,0,0.0120693647460237,0.024594284612871,0,0,0.0987233636602719,0.0126584026269926,0.0121205837275654,0,0.0126611541629665,0.0119678439193793,0.011997876300932,0.0117036084863284,0.0238642266546656,0.0120993315088415,0.0116440880347456,0,0.0605080958074551,0,0.0119621270325795,0,0,0.0499066623977775,0,0,0.0118309809792077,152,"adrenoceptor alpha 2C","protein_coding","hsa04022,hsa04080","cGMP-PKG signaling pathway|Neuroactive ligand-receptor interaction","GO:0004938,GO:0005515,GO:0005737,GO:0005768,GO:0005886,GO:0006940,GO:0007186,GO:0007267,GO:0010700,GO:0019229,GO:0030168,GO:0031694,GO:0032148,GO:0032811,GO:0035624,GO:0042803,GO:0043410,GO:0045666,GO:0046982,GO:0051379,GO:0071875,GO:0071880","alpha2-adrenergic receptor activity|protein binding|cytoplasm|endosome|plasma membrane|regulation of smooth muscle contraction|G protein-coupled receptor signaling pathway|cell-cell signaling|negative regulation of norepinephrine secretion|regulation of vasoconstriction|platelet activation|alpha-2A adrenergic receptor binding|activation of protein kinase B activity|negative regulation of epinephrine secretion|receptor transactivation|protein homodimerization activity|positive regulation of MAPK cascade|positive regulation of neuron differentiation|protein heterodimerization activity|epinephrine binding|adrenergic receptor signaling pathway|adenylate cyclase-activating adrenergic receptor signaling pathway","WP4589,WP455,WP58","Major receptors targeted by epinephrine and norepinephrine|GPCRs, class A rhodopsin-like|Monoamine GPCRs","R-HSA-109582,R-HSA-1430728,R-HSA-162582,R-HSA-163685,R-HSA-372790,R-HSA-373076,R-HSA-375280,R-HSA-388396,R-HSA-390696,R-HSA-392023,R-HSA-392499,R-HSA-400042,R-HSA-418594,R-HSA-418597,R-HSA-422356,R-HSA-500792,R-HSA-5683826,R-HSA-76002,R-HSA-76009","Hemostasis|Metabolism|Signal Transduction|Integration of energy metabolism|Signaling by GPCR|Class A/1 (Rhodopsin-like receptors)|Amine ligand-binding receptors|GPCR downstream signalling|Adrenoceptors|Adrenaline signalling through Alpha-2 adrenergic receptor|Metabolism of proteins|Adrenaline,noradrenaline inhibits insulin secretion|G alpha (i) signalling events|G alpha (z) signalling events|Regulation of insulin secretion|GPCR ligand binding|Surfactant metabolism|Platelet activation, signaling and aggregation|Platelet Aggregation (Plug Formation)"]
["ADRB1",0,0,0,0,0,0,0,0,0,0,0.0417090523461999,0,0,0.0169130970954895,0.00824913766953455,0,0,0.00820718544601026,0,0.0170593407330791,0,0.0505881068189248,0,0.00866583884754017,0.00879401701678508,0.0421409229907526,0.0515005614905109,0.00833891453026095,153,"adrenoceptor beta 1","protein_coding","hsa04020,hsa04024,hsa04022,hsa04080,hsa04540,hsa04923,hsa04924,hsa04261,hsa04970,hsa05207,hsa05414","Calcium signaling pathway|cAMP signaling pathway|cGMP-PKG signaling pathway|Neuroactive ligand-receptor interaction|Gap junction|Regulation of lipolysis in adipocytes|Renin secretion|Adrenergic signaling in cardiomyocytes|Salivary secretion|Chemical carcinogenesis - receptor activation|Dilated cardiomyopathy","GO:0001996,GO:0001997,GO:0002024,GO:0002025,GO:0004939,GO:0004940,GO:0005515,GO:0005769,GO:0005886,GO:0009409,GO:0030165,GO:0031649,GO:0031694,GO:0040015,GO:0042596,GO:0043547,GO:0045187,GO:0046982,GO:0050873,GO:0060078,GO:0071880,GO:0098685,GO:0098992,GO:0099579,GO:0120162","positive regulation of heart rate by epinephrine-norepinephrine|positive regulation of the force of heart contraction by epinephrine-norepinephrine|diet induced thermogenesis|norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure|beta-adrenergic receptor activity|beta1-adrenergic receptor activity|protein binding|early endosome|plasma membrane|response to cold|PDZ domain binding|heat generation|alpha-2A adrenergic receptor binding|negative regulation of multicellular organism growth|fear response|positive regulation of GTPase activity|regulation of circadian sleep/wake cycle, sleep|protein heterodimerization activity|brown fat cell differentiation|regulation of postsynaptic membrane potential|adenylate cyclase-activating adrenergic receptor signaling pathway|Schaffer collateral - CA1 synapse|neuronal dense core vesicle|G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential|positive regulation of cold-induced thermogenesis","WP4589,WP455,WP2197,WP5344,WP3298,WP58,WP536","Major receptors targeted by epinephrine and norepinephrine|GPCRs, class A rhodopsin-like|Endothelin pathways|Cardiomyocyte signaling pathways converging on Titin|Melatonin metabolism and effects|Monoamine GPCRs|Calcium regulation in cardiac cells","R-HSA-162582,R-HSA-372790,R-HSA-373076,R-HSA-375280,R-HSA-388396,R-HSA-390696,R-HSA-418555,R-HSA-500792","Signal Transduction|Signaling by GPCR|Class A/1 (Rhodopsin-like receptors)|Amine ligand-binding receptors|GPCR downstream signalling|Adrenoceptors|G alpha (s) signalling events|GPCR ligand binding"]
["ADRB2",4.4190516779087,2.77669329711664,2.52697436598366,2.76120444435484,3.02267789742121,2.50240372756683,2.14892385780067,2.04847301377342,2.30330105862896,2.51497596481211,1.98977665103388,2.34421929745203,2.06303512737223,1.26390742802932,1.50688755822333,1.49821819978307,2.31744573102282,2.14351869184478,1.84406996693842,2.08609550696176,1.63045426350786,1.79474691039927,2.27382793434181,2.3418041143188,2.3100611436849,1.73045325740387,1.65866090539135,1.83801606735698,154,"adrenoceptor beta 2","protein_coding","hsa04020,hsa04024,hsa04022,hsa04080,hsa04923,hsa04924,hsa04261,hsa04970,hsa05207","Calcium signaling pathway|cAMP signaling pathway|cGMP-PKG signaling pathway|Neuroactive ligand-receptor interaction|Regulation of lipolysis in adipocytes|Renin secretion|Adrenergic signaling in cardiomyocytes|Salivary secretion|Chemical carcinogenesis - receptor activation","GO:0001540,GO:0002024,GO:0002025,GO:0002028,GO:0002032,GO:0004941,GO:0005515,GO:0005634,GO:0005764,GO:0005768,GO:0005769,GO:0005794,GO:0005886,GO:0006366,GO:0006898,GO:0006939,GO:0007166,GO:0007171,GO:0007188,GO:0007190,GO:0008179,GO:0008333,GO:0009409,GO:0010008,GO:0010739,GO:0015459,GO:0016020,GO:0016324,GO:0030501,GO:0030669,GO:0031649,GO:0040015,GO:0042802,GO:0042803,GO:0043235,GO:0043410,GO:0044877,GO:0045453,GO:0045944,GO:0045986,GO:0050873,GO:0051380,GO:0061885,GO:0071875,GO:0071880,GO:0071902,GO:0098992,GO:0120162,GO:1901098,GO:1904504,GO:1904646,GO:1990911,GO:2000481,GO:2000969","amyloid-beta binding|diet induced thermogenesis|norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure|regulation of sodium ion transport|desensitization of G protein-coupled receptor signaling pathway by arrestin|beta2-adrenergic receptor activity|protein binding|nucleus|lysosome|endosome|early endosome|Golgi apparatus|plasma membrane|transcription by RNA polymerase II|receptor-mediated endocytosis|smooth muscle contraction|cell surface receptor signaling pathway|activation of transmembrane receptor protein tyrosine kinase activity|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|activation of adenylate cyclase activity|adenylate cyclase binding|endosome to lysosome transport|response to cold|endosome membrane|positive regulation of protein kinase A signaling|potassium channel regulator activity|membrane|apical plasma membrane|positive regulation of bone mineralization|clathrin-coated endocytic vesicle membrane|heat generation|negative regulation of multicellular organism growth|identical protein binding|protein homodimerization activity|receptor complex|positive regulation of MAPK cascade|protein-containing complex binding|bone resorption|positive regulation of transcription by RNA polymerase II|negative regulation of smooth muscle contraction|brown fat cell differentiation|norepinephrine binding|positive regulation of mini excitatory postsynaptic potential|adrenergic receptor signaling pathway|adenylate cyclase-activating adrenergic receptor signaling pathway|positive regulation of protein serine/threonine kinase activity|neuronal dense core vesicle|positive regulation of cold-induced thermogenesis|positive regulation of autophagosome maturation|positive regulation of lipophagy|cellular response to amyloid-beta|response to psychosocial stress|positive regulation of cAMP-dependent protein kinase activity|positive regulation of AMPA receptor activity","WP4962,WP4589,WP5342,WP455,WP5344,WP58,WP536,WP2877,WP117,WP3888","Airway smooth muscle cell contraction|Major receptors targeted by epinephrine and norepinephrine|Pathophysiological roles of DUX4 in FSHD1|GPCRs, class A rhodopsin-like|Cardiomyocyte signaling pathways converging on Titin|Monoamine GPCRs|Calcium regulation in cardiac cells|Vitamin D receptor pathway|GPCRs, other|VEGFA-VEGFR2 signaling","R-HSA-162582,R-HSA-199991,R-HSA-372790,R-HSA-373076,R-HSA-375280,R-HSA-388396,R-HSA-390696,R-HSA-392499,R-HSA-418555,R-HSA-500792,R-HSA-5653656,R-HSA-5688426,R-HSA-5689880,R-HSA-597592,R-HSA-8856825,R-HSA-8856828","Signal Transduction|Membrane Trafficking|Signaling by GPCR|Class A/1 (Rhodopsin-like receptors)|Amine ligand-binding receptors|GPCR downstream signalling|Adrenoceptors|Metabolism of proteins|G alpha (s) signalling events|GPCR ligand binding|Vesicle-mediated transport|Deubiquitination|Ub-specific processing proteases|Post-translational protein modification|Cargo recognition for clathrin-mediated endocytosis|Clathrin-mediated endocytosis"]
["ADRM1",34.738821534844,32.2198773463802,30.8099529120359,37.4017711412653,27.1541648987967,30.7167635958126,33.0982715189417,32.5887094139317,30.8727160307633,44.9944485335808,42.3182027316934,35.6375436737634,29.1275897372142,32.508533311243,29.368112752191,28.0891398904287,36.7350942578408,39.027487560297,43.8379091326605,34.7196364360064,39.0658343221276,38.9366240040494,37.6463602046902,35.9622771170146,33.6999827332306,43.3345809067033,41.5501023114708,46.0772055972328,11047,"ADRM1 26S proteasome ubiquitin receptor","protein_coding","hsa03050,hsa05169,hsa05010,hsa05012,hsa05014,hsa05016,hsa05017,hsa05020,hsa05022","Proteasome|Epstein-Barr virus infection|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Spinocerebellar ataxia|Prion disease|Pathways of neurodegeneration - multiple diseases","GO:0000502,GO:0002020,GO:0005515,GO:0005654,GO:0005829,GO:0005886,GO:0006368,GO:0008541,GO:0043161,GO:0043248,GO:0061133,GO:0070628,GO:0140678","proteasome complex|protease binding|protein binding|nucleoplasm|cytosol|plasma membrane|transcription elongation by RNA polymerase II|proteasome regulatory particle, lid subcomplex|proteasome-mediated ubiquitin-dependent protein catabolic process|proteasome assembly|endopeptidase activator activity|proteasome binding|molecular function inhibitor activity","WP5124,WP2059","Alzheimer's disease|Alzheimer's disease and miRNA effects","R-HSA-392499,R-HSA-5688426,R-HSA-5689603,R-HSA-5689880,R-HSA-597592","Metabolism of proteins|Deubiquitination|UCH proteinases|Ub-specific processing proteases|Post-translational protein modification"]
["ADSL",14.7731955913107,14.7049714581238,17.0019423308038,16.2842726094254,13.11475796032,14.5532201876934,17.1836665460496,15.0221064586895,14.2506443086835,15.0930225512942,15.7647667501831,15.3907770876837,13.6737790440623,14.414376148109,14.5385863652909,14.6583750270999,18.1391381891221,17.0563769445495,18.9162751508849,15.6829992825765,17.1029864059012,15.7746452883686,18.3159091609817,17.3439106956761,15.734789767426,19.067358447325,18.544706498632,18.656970474401,158,"adenylosuccinate lyase","protein_coding","hsa00230,hsa00250","Purine metabolism|Alanine, aspartate and glutamate metabolism","GO:0001666,GO:0004018,GO:0005829,GO:0006164,GO:0006167,GO:0006177,GO:0006189,GO:0007584,GO:0009060,GO:0014850,GO:0032991,GO:0042594,GO:0042802,GO:0044208,GO:0044209,GO:0070626,GO:0097294","response to hypoxia|N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity|cytosol|purine nucleotide biosynthetic process|AMP biosynthetic process|GMP biosynthetic process|'de novo' IMP biosynthetic process|response to nutrient|aerobic respiration|response to muscle activity|protein-containing complex|response to starvation|identical protein binding|'de novo' AMP biosynthetic process|AMP salvage|(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity|'de novo' XMP biosynthetic process","WP4792,WP4224","Purine metabolism|Purine metabolism and related disorders","R-HSA-1430728,R-HSA-15869,R-HSA-73817,R-HSA-8956320","Metabolism|Metabolism of nucleotides|Purine ribonucleoside monophosphate biosynthesis|Nucleotide biosynthesis"]
["ADSS1",0.644086558718198,0.828189297958095,0.817453344135372,1.22399379805316,1.30536886189517,1.71368528849908,0.912518690861612,0.947383907178347,1.07977294620868,1.14877390904624,0.661811928736814,0.76800544331538,0.714607374134763,0.72777206475317,0.621181966881446,1.02912893539396,1.22703282559178,0.99325101386649,0.529136474685093,1.13550670625993,1.12578185924447,0.963692242841488,0.541654453241878,0.780742232417786,1.37172657293147,1.13332977848581,0.242383062961867,0.897060575485417,122622,"adenylosuccinate synthase 1","protein_coding","hsa00230,hsa00250","Purine metabolism|Alanine, aspartate and glutamate metabolism","GO:0000287,GO:0002376,GO:0003924,GO:0004019,GO:0005525,GO:0005737,GO:0005829,GO:0006167,GO:0006531,GO:0006541,GO:0014850,GO:0042301,GO:0042594,GO:0042802,GO:0044208,GO:0046040,GO:0051015,GO:0071257,GO:0071466","magnesium ion binding|immune system process|GTPase activity|adenylosuccinate synthase activity|GTP binding|cytoplasm|cytosol|AMP biosynthetic process|aspartate metabolic process|glutamine metabolic process|response to muscle activity|phosphate ion binding|response to starvation|identical protein binding|'de novo' AMP biosynthetic process|IMP metabolic process|actin filament binding|cellular response to electrical stimulus|cellular response to xenobiotic stimulus",null,null,"R-HSA-1430728,R-HSA-15869,R-HSA-73817,R-HSA-8956320","Metabolism|Metabolism of nucleotides|Purine ribonucleoside monophosphate biosynthesis|Nucleotide biosynthesis"]
["ADSS2",27.2480845417345,21.3632225960697,20.6687373844379,19.6476936672021,26.0960196201956,20.4581256835362,19.0747671138638,19.6323777690974,24.9124412461698,16.8597600870474,20.1682009748488,22.5477236143502,25.1196435905788,19.0675483586811,21.3530300242258,20.0040910967615,27.5403243297166,26.394797144005,26.5898240082474,29.3966018574314,30.9654150965055,26.2966408273188,31.7021790480145,33.3623536071701,30.8381488239,26.4056196757216,29.8374059320354,25.1851664468986,159,"adenylosuccinate synthase 2","protein_coding","hsa00230,hsa00250","Purine metabolism|Alanine, aspartate and glutamate metabolism","GO:0000287,GO:0002376,GO:0004019,GO:0005515,GO:0005525,GO:0005737,GO:0005739,GO:0005829,GO:0006167,GO:0006531,GO:0014074,GO:0042301,GO:0044208,GO:0046040,GO:0060359,GO:0070062,GO:0071257","magnesium ion binding|immune system process|adenylosuccinate synthase activity|protein binding|GTP binding|cytoplasm|mitochondrion|cytosol|AMP biosynthetic process|aspartate metabolic process|response to purine-containing compound|phosphate ion binding|'de novo' AMP biosynthetic process|IMP metabolic process|response to ammonium ion|extracellular exosome|cellular response to electrical stimulus","WP4792,WP4224","Purine metabolism|Purine metabolism and related disorders","R-HSA-1430728,R-HSA-15869,R-HSA-73817,R-HSA-8956320","Metabolism|Metabolism of nucleotides|Purine ribonucleoside monophosphate biosynthesis|Nucleotide biosynthesis"]
["ADTRP",0.106516232936326,0.0470389260204548,0.0357147328466693,0.0510776333620884,0.0408898203534057,0.032150626355265,0.0177461934676005,0.0634157593198762,0.0153058416184127,0.021983311045254,0.0214655055173754,0.0153091686238071,0.0180885701914412,0.00725358482545762,0.0318405538243634,0.0216414790407679,0.021944765530854,0.00351984710279779,0.0175793882419017,0,0.0394961007914444,0.112095562971683,0.037555346866652,0.0408820670102202,0.0226291428569092,0.0325316507118282,0.0184060361240077,0.0178817113021895,84830,"androgen dependent TFPI regulating protein","protein_coding",null,null,"GO:0001934,GO:0002042,GO:0002686,GO:0003332,GO:0005515,GO:0005901,GO:0009986,GO:0010628,GO:0012505,GO:0016020,GO:0016787,GO:0030195,GO:0042758,GO:0043491,GO:0050709,GO:0071383,GO:0140052,GO:1903038,GO:2000402","positive regulation of protein phosphorylation|cell migration involved in sprouting angiogenesis|negative regulation of leukocyte migration|negative regulation of extracellular matrix constituent secretion|protein binding|caveola|cell surface|positive regulation of gene expression|endomembrane system|membrane|hydrolase activity|negative regulation of blood coagulation|long-chain fatty acid catabolic process|phosphatidylinositol 3-kinase/protein kinase B signal transduction|negative regulation of protein secretion|cellular response to steroid hormone stimulus|cellular response to oxidised low-density lipoprotein particle stimulus|negative regulation of leukocyte cell-cell adhesion|negative regulation of lymphocyte migration"]
["AEBP1",80.5354496376252,105.672651766004,96.3106476328752,110.872852754596,97.7457758649812,118.578450252993,95.0222673302028,106.687289594156,93.6251598860224,126.363236717679,116.216593197533,96.9780213210652,91.8788607209144,121.072692498633,103.442057114785,112.610166862914,48.3348353047667,65.0924727557776,50.4791409057919,59.1624696686708,51.5081489743288,61.5731499197849,35.8993763411352,42.9499451211566,49.900517806285,62.1521786169946,35.1888757736929,56.4697023269789,165,"AE binding protein 1","protein_coding",null,null,"GO:0000122,GO:0000977,GO:0001227,GO:0004181,GO:0005201,GO:0005516,GO:0005518,GO:0005576,GO:0005615,GO:0005634,GO:0005737,GO:0006518,GO:0008270,GO:0016485,GO:0062023,GO:0070062,GO:1904026","negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|metallocarboxypeptidase activity|extracellular matrix structural constituent|calmodulin binding|collagen binding|extracellular region|extracellular space|nucleus|cytoplasm|peptide metabolic process|zinc ion binding|protein processing|collagen-containing extracellular matrix|extracellular exosome|regulation of collagen fibril organization"]
["AEBP2",3.7559760958735,3.8379704104052,3.13952219353239,2.58270920241168,3.97747289450109,3.43138996862675,3.44643790483476,3.0793830199814,4.25470834666486,2.90934637116522,2.58256201937769,3.00345211211109,4.41011705455967,3.1205873013547,3.71958985016055,4.21216932425046,3.11290789931106,3.03266695072537,2.85322309964622,3.52238245772538,3.25244779407224,3.13233976687748,4.27641488273678,3.86421088434167,3.4163759088892,2.8576074240513,3.24027045720958,2.78986428565564,121536,"AE binding protein 2","protein_coding","hsa03083","Polycomb repressive complex","GO:0000122,GO:0000785,GO:0003677,GO:0003712,GO:0005654,GO:0006325,GO:0006357,GO:0035098,GO:0046872","negative regulation of transcription by RNA polymerase II|chromatin|DNA binding|transcription coregulator activity|nucleoplasm|chromatin organization|regulation of transcription by RNA polymerase II|ESC/E(Z) complex|metal ion binding","WP2916,WP2853,WP2857,WP2369","Interactome of polycomb repressive complex 2 (PRC2) |Endoderm differentiation|Mesodermal commitment pathway|Histone modifications","R-HSA-212165,R-HSA-212300,R-HSA-3214841,R-HSA-3247509,R-HSA-4839726,R-HSA-74160","Epigenetic regulation of gene expression|PRC2 methylates histones and DNA|PKMTs methylate histone lysines|Chromatin modifying enzymes|Chromatin organization|Gene expression (Transcription)","other"]
["AEN",11.9093442719639,10.4608417259435,9.48511143082564,10.9025836415066,9.37030148200576,9.39910385009963,8.26648529368497,8.79661584568472,8.53989276277192,8.84739525467462,7.7506837967013,7.84151459391227,7.85338256241584,7.2358700254679,7.0224384957658,6.79816508151571,8.31142255407457,7.78915043715737,8.40320406578534,8.77512211863638,8.72767000239354,8.28543001880603,7.37275487780481,8.69934439003513,8.94302334569223,7.83618580321982,7.64911561868126,8.1738211105014,64782,"apoptosis enhancing nuclease","protein_coding",null,null,"GO:0003676,GO:0004527,GO:0004529,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0006259,GO:0010212,GO:0031965,GO:0042771","nucleic acid binding|exonuclease activity|DNA exonuclease activity|protein binding|nucleus|nucleoplasm|nucleolus|DNA metabolic process|response to ionizing radiation|nuclear membrane|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator"]
["AFAP1",7.49657598637279,7.3252633260914,5.73130514069396,5.2855047598888,7.28763880608027,6.99228986909246,5.86175819600287,5.47987219063428,7.76144180449711,7.66892271211561,6.32722420899682,7.539192485755,8.88183726876609,7.93647034654329,9.00313773313971,9.2154983592322,6.62827835269991,6.26904726304973,4.9728274630381,7.11183499546769,7.2941443057669,6.57568250555146,5.80986880546012,6.85714194312456,7.24691386431865,5.47062763491491,5.2870800749853,5.52428529007781,60312,"actin filament associated protein 1","protein_coding",null,null,"GO:0003779,GO:0005829,GO:0005925,GO:0015629,GO:0017124,GO:0042169","actin binding|cytosol|focal adhesion|actin cytoskeleton|SH3 domain binding|SH2 domain binding","WP5199","PtdIns(4,5)P2 in cytokinesis pathway"]
["AFAP1-AS1",0.186452114209922,0.120746822357957,0.0446930855543485,0.0837022434571922,0.139552205670913,0.163912204849153,0.0592197919229632,0.0894721345490611,0.163603566667806,0.133727764835257,0.0783467258773256,0.13570074104202,0.196177531584422,0.117245471984471,0.0700976391724201,0.199353215246326,0.106794629370755,0.0293646935339811,0.0586631558885607,0.0686666708448047,0.0823750905689993,0.0678751684868489,0.0587455160920743,0.116271453676267,0.149455581034933,0.105543941696221,0.0806160003375746,0.0447540154657184,84740,"AFAP1 antisense RNA 1","non_coding"]
["AFAP1L1",2.40493774402867,2.10449521936049,2.33637525502159,1.93342796211694,2.1579166512278,1.94022503485188,2.37646119128171,2.03836939769725,0.971823574343088,0.999014430631866,0.99121676152632,1.01832219030752,1.04211045445017,0.801487922165378,0.984094605517769,0.959686267309472,1.39134239872936,1.33125259584581,1.34134796411153,1.41573735017186,1.39352405223902,1.3874916617876,1.15613363244665,1.3811316802318,1.52595911850358,1.4108153316977,1.15348872033498,1.40373625584395,134265,"actin filament associated protein 1 like 1","protein_coding",null,null,"GO:0002102,GO:0005515,GO:0005829,GO:0017124,GO:0042995,GO:0070161","podosome|protein binding|cytosol|SH3 domain binding|cell projection|anchoring junction"]
["AFAP1L2",0.223558733060438,0.132310233262445,0.121266854418337,0.185818391476839,0.271851605960477,0.19593750687724,0.190037987591894,0.136404175702369,0.089947912216426,0.0669871110988262,0.107458077104398,0.0899674640448467,0.132285920919405,0.113672470489921,0.032341302182825,0.18370528624009,0.353453895835506,0.28499474149767,0.151519682554729,0.234088047171355,0.356366185300092,0.311667862670446,0.073567228500856,0.232971478873641,0.497461627186693,0.25490520856323,0.168259528902143,0.284898569241659,84632,"actin filament associated protein 1 like 2","protein_coding",null,null,"GO:0005737,GO:0005829,GO:0005886,GO:0006954,GO:0007346,GO:0017124,GO:0030296,GO:0032675,GO:0032757,GO:0042169,GO:0045742,GO:0045893","cytoplasm|cytosol|plasma membrane|inflammatory response|regulation of mitotic cell cycle|SH3 domain binding|protein tyrosine kinase activator activity|regulation of interleukin-6 production|positive regulation of interleukin-8 production|SH2 domain binding|positive regulation of epidermal growth factor receptor signaling pathway|positive regulation of DNA-templated transcription"]
["AFDN",5.45330122406078,5.85628381323146,5.17939309268997,4.6559480686348,5.99960330604796,5.10945614180731,4.56131248707959,4.22384640923834,6.86397493942371,5.94876008254846,5.07336921339372,6.19686436864356,7.82785506427275,6.58500390469118,7.25511919723063,7.85544889509427,5.219528568865,5.08643907218859,4.93844323564918,5.68101095022056,5.18400455021693,4.95132528353762,6.04932391231685,5.64280656078516,5.88856322512081,4.71963594093661,5.41891587358027,4.3664523112877,4301,"afadin%2C adherens junction formation factor","protein_coding","hsa04014,hsa04015,hsa04024,hsa04520,hsa04530,hsa04670","Ras signaling pathway|Rap1 signaling pathway|cAMP signaling pathway|Adherens junction|Tight junction|Leukocyte transendothelial migration","GO:0005515,GO:0005654,GO:0005829,GO:0005886,GO:0005911,GO:0005912,GO:0007155,GO:0007165,GO:0007267,GO:0010628,GO:0016607,GO:0022409,GO:0030054,GO:0030336,GO:0031267,GO:0032880,GO:0044291,GO:0044331,GO:0045296,GO:0046930,GO:0046931,GO:0050839,GO:0051015,GO:0061951,GO:0070160,GO:0070830,GO:0090557,GO:2000049","protein binding|nucleoplasm|cytosol|plasma membrane|cell-cell junction|adherens junction|cell adhesion|signal transduction|cell-cell signaling|positive regulation of gene expression|nuclear speck|positive regulation of cell-cell adhesion|cell junction|negative regulation of cell migration|small GTPase binding|regulation of protein localization|cell-cell contact zone|cell-cell adhesion mediated by cadherin|cadherin binding|pore complex|pore complex assembly|cell adhesion molecule binding|actin filament binding|establishment of protein localization to plasma membrane|tight junction|bicellular tight junction assembly|establishment of endothelial intestinal barrier|positive regulation of cell-cell adhesion mediated by cadherin","WP4223,WP3888,WP4905","Ras signaling|VEGFA-VEGFR2 signaling|1q21.1 copy number variation syndrome","R-HSA-1500931,R-HSA-1500931,R-HSA-418990,R-HSA-418990,R-HSA-421270,R-HSA-421270,R-HSA-446728,R-HSA-446728","Cell-Cell communication|Cell-Cell communication|Adherens junctions interactions|Adherens junctions interactions|Cell-cell junction organization|Cell-cell junction organization|Cell junction organization|Cell junction organization"]
["AFDN-DT",0,0.0110946919342589,0.0219017392428817,0.0671205000934213,0,0,0.0217653876090726,0.0571899191260013,0.0117327124305574,0.0224684468580225,0.0219392142068544,0.0352057882523682,0,0.0667229364861869,0.0325432229048665,0.0221190711788376,0,0,0.0107804019975868,0.0112166457135066,0.0220187538026179,0.0221747088738948,0.0460609585282729,0.0569785466414422,0.0346927966862958,0.0221663807821544,0.146735373056802,0.0219315977996218,653483,"AFDN divergent transcript","non_coding",null,null,"GO:0003674,GO:0005575,GO:0008150","molecular_function|cellular_component|biological_process"]
["AFF1",4.36576690421318,4.29745287982805,3.1161481997947,2.82276613056939,4.80380041192035,3.87589104016006,2.9592169019803,2.77293026737728,4.47292017434405,3.04297351284691,3.04985470845305,3.61124688563121,4.69151698177393,3.71484955742269,5.11801401805347,4.66353360078272,3.08251753189754,3.06201097888832,2.52268579267645,3.53434339162367,3.3762784859237,2.9354680333994,3.90977858995734,3.24753100625535,3.4417107209165,2.36009832088142,2.95513103836266,2.56606990129798,4299,"AF4/FMR2 family member 1","protein_coding","hsa05202","Transcriptional misregulation in cancer","GO:0005515,GO:0008023,GO:0010468,GO:0032783","protein binding|transcription elongation factor complex|regulation of gene expression|super elongation complex"]
["AFF1-AS1",1.03944274686027,0.553662204896167,1.05393533948953,0.757633428946539,1.00215703481155,1.05417688698235,1.00858232381393,1.1415872350042,0.543680019873372,0.253616203878897,0.49528481059577,0.515911111584447,0.975320824664772,0.396392560975779,0.915119889880617,0.867283663399329,0.612941558986722,0.705290494279376,0.576405092924956,0.706348800476827,0.941836627949923,0.816770343668225,1.17666211615168,1.25922881026413,0.865643247291836,0.684775915514926,0.89855902542994,0.846903589581027,100506746,"AFF1 antisense RNA 1","non_coding"]
["AFF2",0.0640474550192975,0.070150022052182,0.0801733909271074,0.0632866077992234,0.111893458881323,0.0546762037951876,0.0688095906492023,0.0399666493643022,0.976106934517179,0.915942275813816,0.766600910557171,0.88845038942824,1.07051411704803,0.610614071716955,0.938580695256107,0.837292603495704,0.365734505437393,0.362748260294181,0.274445019764759,0.311679645527655,0.272946780388784,0.225069543139306,0.337221002735179,0.314759189774208,0.344429272863976,0.27293264044059,0.294862869897485,0.264567958984242,2334,"AF4/FMR2 family member 2","protein_coding",null,null,"GO:0002151,GO:0006397,GO:0007420,GO:0007611,GO:0008380,GO:0010468,GO:0010629,GO:0016607,GO:0032783,GO:0035063,GO:0043484","G-quadruplex RNA binding|mRNA processing|brain development|learning or memory|RNA splicing|regulation of gene expression|negative regulation of gene expression|nuclear speck|super elongation complex|nuclear speck organization|regulation of RNA splicing","WP5316","Primary ovarian insufficiency"]
["AFF3",0.479021644256934,0.566389714644968,0.508112071833307,0.36042081965633,0.681431070558284,0.626276714338563,0.500010391233852,0.512547560007606,0.970316801006149,0.805466962725899,0.552537348932945,0.772161969756179,0.844394808508831,0.890668716893477,0.850364164744068,1.07649440032654,0.417294189492703,0.424856309947353,0.227475954889534,0.453002498396411,0.403415758485728,0.353445004426081,0.295235798265887,0.372324356497485,0.408005523001181,0.319364108802708,0.2625021869797,0.311005366175728,3899,"AF4/FMR2 family member 3","protein_coding",null,null,"GO:0003690,GO:0003700,GO:0005634,GO:0005654,GO:0005829,GO:0006355,GO:0010468,GO:0016604,GO:0032783,GO:0034612,GO:0035116","double-stranded DNA binding|DNA-binding transcription factor activity|nucleus|nucleoplasm|cytosol|regulation of DNA-templated transcription|regulation of gene expression|nuclear body|super elongation complex|response to tumor necrosis factor|embryonic hindlimb morphogenesis"]
["AFF4",16.8190907281614,15.4004483366066,11.3955029789072,10.027129884418,18.8150072090344,13.4505411432041,11.4412286385115,10.2336607906741,16.6825670334044,10.8106390512518,9.98844566323028,12.1461046426005,18.8359718158847,11.9348499418642,15.4469927892135,17.4316984843641,9.83248099655839,9.21603029387232,8.72073313795932,12.9843612512625,11.4409908848715,10.7830034268955,14.9241395915263,13.0402609626041,10.7482221302411,8.77969412322069,10.8459657937024,7.70277039431158,27125,"AF4/FMR2 family member 4","protein_coding","hsa03250","Viral life cycle - HIV-1","GO:0000791,GO:0001650,GO:0005515,GO:0005654,GO:0007286,GO:0008023,GO:0010468,GO:0032783,GO:0034976","euchromatin|fibrillar center|protein binding|nucleoplasm|spermatid development|transcription elongation factor complex|regulation of gene expression|super elongation complex|response to endoplasmic reticulum stress",null,null,"R-HSA-112382,R-HSA-674695,R-HSA-73857,R-HSA-74160,R-HSA-75955","Formation of RNA Pol II elongation complex |RNA Polymerase II Pre-transcription Events|RNA Polymerase II Transcription|Gene expression (Transcription)|RNA Polymerase II Transcription Elongation","AF_4"]
["AFG1L",0.633363967502307,0.602434216053917,0.583134428843975,0.604498448684727,0.66374418820947,0.586141316989473,0.810734747851135,0.636076537054258,0.532437415195703,0.433195990991308,0.460399764195602,0.501769731144508,0.567406211882583,0.428810363493718,0.546341979627852,0.432262136813267,0.620708066674125,0.47844910106718,0.602335689046325,0.582575517854134,0.563146498716274,0.558410012704518,1.03305423678555,0.624757799075367,0.63399871761953,0.718101417646257,0.84976218744028,0.552287918437333,246269,"AFG1 like ATPase","protein_coding",null,null,"GO:0005515,GO:0005524,GO:0005737,GO:0005739,GO:0006123,GO:0007005,GO:0016887,GO:0031966,GO:0035694","protein binding|ATP binding|cytoplasm|mitochondrion|mitochondrial electron transport, cytochrome c to oxygen|mitochondrion organization|ATP hydrolysis activity|mitochondrial membrane|mitochondrial protein catabolic process"]
["AFG3L2",16.9536467812031,16.4341681365918,17.1344460304916,17.1207550052452,15.892034723218,17.3023392210279,17.4466801988758,16.7633002328185,15.6563746623621,15.5117077104226,18.172477151521,17.9434954674967,14.8418024011591,14.9424630487304,16.1070316143681,14.1273866288979,15.8282544176552,17.5330011548423,15.3461682621212,16.0071498532743,14.510640612274,16.6762086918529,13.7737397067035,14.8736186538563,15.7943041147572,16.4487331070477,14.0643553739548,16.1494423065757,10939,"AFG3 like matrix AAA peptidase subunit 2","protein_coding","hsa05017","Spinocerebellar ataxia","GO:0004176,GO:0004222,GO:0005515,GO:0005524,GO:0005739,GO:0005743,GO:0005745,GO:0006508,GO:0007409,GO:0007528,GO:0008053,GO:0008237,GO:0008270,GO:0016485,GO:0016540,GO:0016887,GO:0021675,GO:0033619,GO:0034982,GO:0036444,GO:0040014,GO:0042407,GO:0042552,GO:0051082,GO:0051560,GO:0055001,GO:0060013","ATP-dependent peptidase activity|metalloendopeptidase activity|protein binding|ATP binding|mitochondrion|mitochondrial inner membrane|m-AAA complex|proteolysis|axonogenesis|neuromuscular junction development|mitochondrial fusion|metallopeptidase activity|zinc ion binding|protein processing|protein autoprocessing|ATP hydrolysis activity|nerve development|membrane protein proteolysis|mitochondrial protein processing|calcium import into the mitochondrion|regulation of multicellular organism growth|cristae formation|myelination|unfolded protein binding|mitochondrial calcium ion homeostasis|muscle cell development|righting reflex","WP5402,WP4352","10q22q23 copy number variation|Ciliary landscape","R-HSA-382551,R-HSA-8949215,R-HSA-8949664","Transport of small molecules|Mitochondrial calcium ion transport|Processing of SMDT1"]
["AFMID",8.32126644218374,7.7253931785349,7.44919574505063,8.92475997959579,7.90214364611545,7.69302983135422,7.7636664440962,8.07935911995069,8.67657549664582,7.42747262897602,7.03208094183521,8.14784905304277,7.80199355335539,8.50316619080427,7.17195092632035,7.4231025856931,9.18355043257824,9.09827525329858,9.88957988347579,8.84717807455318,9.19254729814203,9.70327177669441,8.9438515758459,9.77847980698004,9.64424552288182,10.1005306371121,10.7515706984377,10.4122406036098,125061,"arylformamidase","protein_coding","hsa00630,hsa00380","Glyoxylate and dicarboxylate metabolism|Tryptophan metabolism","GO:0004061,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0019441,GO:0034354","arylformamidase activity|protein binding|nucleus|cytoplasm|cytosol|tryptophan catabolic process to kynurenine|'de novo' NAD biosynthetic process from tryptophan","WP2485,WP465,WP5044,WP4210","NAD biosynthesis II (from tryptophan)|Tryptophan metabolism|Kynurenine pathway and links to cell senescence|Tryptophan catabolism leading to NAD+ production","R-HSA-1430728,R-HSA-71240,R-HSA-71291","Metabolism|Tryptophan catabolism|Metabolism of amino acids and derivatives"]
["AFP",0.0111113830318397,0.0528438438995724,0.0104317640952802,0,0.0217151515419495,0.0208683098244397,0.0103668200256733,0.0108957875597847,0.0111765451059432,0.0107016860447011,0.020899226723842,0.0670738471980404,0.0211336534833557,0,0.0206670481267234,0.010535278955955,0,0.0205619427620982,0.0102693771708256,0.0427397662719105,0.0104874979467951,0.0211235582059237,0.0548469059969284,0.010855517006461,0.0220321662934953,0.0105578124459107,0,0.0104459856790861,174,"alpha fetoprotein","protein_coding","hsa04390","Hippo signaling pathway","GO:0001542,GO:0005515,GO:0005615,GO:0005737,GO:0005788,GO:0006810,GO:0042448,GO:0046872,GO:0060395","ovulation from ovarian follicle|protein binding|extracellular space|cytoplasm|endoplasmic reticulum lumen|transport|progesterone metabolic process|metal ion binding|SMAD protein signal transduction",null,null,"R-HSA-381426,R-HSA-392499,R-HSA-597592,R-HSA-8957275","Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)|Metabolism of proteins|Post-translational protein modification|Post-translational protein phosphorylation"]
["AFTPH",5.29347772336079,5.13286087745188,5.24747851946677,4.26866735048916,5.44910406520488,4.47557278082334,4.64472125170303,4.57266904068895,4.79400981494165,3.39473517269289,4.10112542277781,4.30325168798722,5.13803440879524,3.83866770434486,5.47919888093233,4.92754428339172,4.32873721411525,4.06469524638521,4.68428659149163,5.11506075822397,4.57737370419219,4.03509859902133,5.77190464801863,4.77570222759071,4.80808001822081,3.74634313652751,4.8734387810167,3.52525970248173,54812,"aftiphilin","protein_coding",null,null,"GO:0005654,GO:0005794,GO:0005829,GO:0015031,GO:0030121,GO:0030276,GO:0032588,GO:0043231,GO:0046907,GO:0048471","nucleoplasm|Golgi apparatus|cytosol|protein transport|AP-1 adaptor complex|clathrin binding|trans-Golgi network membrane|intracellular membrane-bounded organelle|intracellular transport|perinuclear region of cytoplasm"]
["AFTPH-DT",0.0137042273692135,0.0391049817896378,0.0385980574913318,0.131431516451361,0,0,0.0255718407547366,0.0940682584342983,0.0137845950315293,0.0131989274755694,0.0644401678088977,0.0413627740982323,0.0260651974329543,0.0261306060361935,0.0637242739647064,0.038981067738404,0,0.0253600778550332,0.0253314784101912,0.0263565513410409,0.0129347585251271,0.0130263732098553,0.0676454468472538,0.0267773098705384,0.0815201353757291,0,0.0265226582561706,0.0128835593581408,101927402,"AFTPH divergent transcript","non_coding"]
["AGA",12.3201945920526,8.64730746797733,9.1688292857244,9.5440057059691,10.1767092938845,8.84783553742577,9.85254025285331,11.4712477506693,7.21450650340886,6.24522448148163,6.81993990416257,6.13765763970116,7.52567636810786,6.37124338413409,7.32259792819869,5.54584945618013,11.476153568448,11.252510558773,12.9765503517059,11.8473604001392,13.1147783602706,12.3145781569003,13.1948139310784,13.1224921558859,12.5425218137424,11.0651264774305,13.3946715646103,9.30573736896532,175,"aspartylglucosaminidase","protein_coding","hsa00511,hsa04142","Other glycan degradation|Lysosome","GO:0003948,GO:0004067,GO:0005515,GO:0005576,GO:0005615,GO:0005737,GO:0005764,GO:0005783,GO:0006508,GO:0006517,GO:0008798,GO:0035578","N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity|asparaginase activity|protein binding|extracellular region|extracellular space|cytoplasm|lysosome|endoplasmic reticulum|proteolysis|protein deglycosylation|beta-aspartyl-peptidase activity|azurophil granule lumen",null,null,"R-HSA-168249,R-HSA-168256,R-HSA-6798695","Innate Immune System|Immune System|Neutrophil degranulation"]
["AGA-DT",0.0623986463778775,0.148378663542086,0.131809685912239,0.16457081721401,0.106703328554799,0.0878932632536297,0.407521614990704,0.183563754305818,0.1098380144613,0.315513945158186,0.0880234792222929,0.17264011249295,0.252197377592754,0.0594894699921211,0.159583578214624,0.11832679049605,0.119985037462678,0.216507261896052,0.158592939340656,0.105006757932521,0.0736188368603154,0.326217172617638,0.123202401804211,0.152404422787468,0.0618634669305783,0.207514781199602,0.150955060155924,0.39596814464786,285500,null,"non_coding"]
["AGAP1",2.30324425345712,2.24125886056539,1.93256461541651,1.86671432949495,2.34284878080771,1.97039378150295,1.82147993688218,1.75536793789868,2.14025122423211,2.30637052236632,1.97885987620267,2.07099110196574,1.92393123672261,1.7755268671966,2.01858533143686,2.05939490610729,1.90537368391036,1.65358916489006,1.62310536833652,1.99931908669757,1.96794132743066,1.69174615487495,1.66532499838235,1.7877761590599,1.91070500258251,1.54960110558066,1.43545454851011,1.6995374706881199,116987,"ArfGAP with GTPase domain%2C ankyrin repeat and PH domain 1","protein_coding","hsa04144","Endocytosis","GO:0003924,GO:0005096,GO:0005515,GO:0005525,GO:0005543,GO:0005737,GO:0015031,GO:0046872,GO:0090630","GTPase activity|GTPase activator activity|protein binding|GTP binding|phospholipid binding|cytoplasm|protein transport|metal ion binding|activation of GTPase activity","WP5224","2q37 copy number variation syndrome"]
["AGAP1-IT1",1.46148154889872,1.08119777964161,1.71511398536407,1.79099193848675,1.86446160325013,1.41052803197391,1.21204363288113,0.91560716003143,0.040834786787678,0.0390998348560919,0.152715433831447,0,0.115821332870379,0.077407985049989,0.0377547129182462,0.0384918475107634,0.312250217975163,0.0751254113567024,0.262642414329762,0.039038656993846,0.038317274124887,0.115766006493006,0.0801557794870773,0.0793237477640801,0.120745561960887,0.655760995322667,0.157138761415324,0.267159230123857,100506749,"AGAP1 intronic transcript 1","non_coding",{"$nulls":4},"WP5224","2q37 copy number variation syndrome"]
["AGAP11",0.851574863835939,1.02353153226596,0.850365532548115,0.935504017815574,1.09688955455364,0.894178907954216,0.917299822960942,0.781912005704737,0.731977039672518,0.559210734013033,0.65524657709415,0.716558783449408,0.463817537491259,0.30260697659404,0.568771171981483,0.477113193154666,0.684762396455586,0.444107256567019,0.4507613635941,0.848670356061507,0.555325365145979,0.522465308262138,0.748980023374942,0.809275363460994,0.552613806837653,0.617895821791348,0.67422547258614,0.64046312195771,119385,"ArfGAP with GTPase domain%2C ankyrin repeat and PH domain 11","non_coding",null,null,"GO:0003924,GO:0005096,GO:0046872,GO:0090630","GTPase activity|GTPase activator activity|metal ion binding|activation of GTPase activity"]
["AGAP2",0.621544929264269,0.229310972029715,0.268776821804274,0.534681628608922,0.471154456261774,0.343122722506065,0.369024603848485,0.343527920299541,0.466050685651654,0.442621495531344,0.262151535660355,0.610166426348375,0.222104184442321,0.359131512529295,0.231213322935889,0.314303470339425,0.325951527148473,0.11850414245311,0.362074474246507,0.304278945289094,0.223992203911721,0.221998088098756,0.442536967017251,0.478425510550265,0.436951798845605,0.379402573692093,0.524908461832295,0.226646942492682,116986,"ArfGAP with GTPase domain%2C ankyrin repeat and PH domain 2","protein_coding","hsa04068,hsa04144","FoxO signaling pathway|Endocytosis","GO:0003924,GO:0005096,GO:0005515,GO:0005524,GO:0005525,GO:0005634,GO:0005654,GO:0005737,GO:0005768,GO:0005829,GO:0015031,GO:0016020,GO:0016197,GO:0019901,GO:0030036,GO:0030295,GO:0035014,GO:0042177,GO:0043524,GO:0045860,GO:0046872,GO:0061903,GO:0070062,GO:0090543,GO:0090630","GTPase activity|GTPase activator activity|protein binding|ATP binding|GTP binding|nucleus|nucleoplasm|cytoplasm|endosome|cytosol|protein transport|membrane|endosomal transport|protein kinase binding|actin cytoskeleton organization|protein kinase activator activity|phosphatidylinositol 3-kinase regulator activity|negative regulation of protein catabolic process|negative regulation of neuron apoptotic process|positive regulation of protein kinase activity|metal ion binding|positive regulation of 1-phosphatidylinositol-3-kinase activity|extracellular exosome|Flemming body|activation of GTPase activity","WP4549,WP5408,WP2037,WP4747","Fragile X syndrome|15q25 copy number variation|Prolactin signaling pathway|Netrin-UNC5B signaling pathway","R-HSA-1266738,R-HSA-373752,R-HSA-422475,R-HSA-9675108","Developmental Biology|Netrin-1 signaling|Axon guidance|Nervous system development"]
["AGAP2-AS1",18.0294999352638,22.1061917957516,25.2578696369621,24.5185794403964,18.2886538119327,24.7015089266269,26.5954910606903,22.5484871912275,18.8259302599087,25.99620581191,26.9238008086538,18.2808872423388,18.9375066066468,22.8122494831707,22.1381207829336,20.8508653476071,19.7719040701399,21.5205107181787,26.264143404642,20.9269640427677,22.4679881551839,22.2087240951817,20.6149565542754,21.6394769406627,20.7027243689194,26.2322538825905,23.4100831212624,26.0040634457703,100130776,"AGAP2 antisense RNA 1","non_coding"]
["AGAP3",7.58020816959969,8.79566233678059,9.6321576401647,9.93589496922828,7.98273860316665,9.01147131903558,8.4606610627141,8.51150983539829,7.92315179873204,10.4866301456031,11.2574292067255,9.47033424190211,7.2502116831419,8.82027459892897,8.79063205959718,8.42849946639764,8.06411336776849,9.53733941708666,10.3453376440222,9.35815447368103,8.92573513534248,9.89324259471075,7.90553731246839,8.18587174595033,8.03870534444395,9.75269079510592,8.45008156455925,10.3632498197104,116988,"ArfGAP with GTPase domain%2C ankyrin repeat and PH domain 3","protein_coding","hsa04144","Endocytosis","GO:0003924,GO:0005096,GO:0005525,GO:0005634,GO:0005737,GO:0031593,GO:0034614,GO:0043161,GO:0046872,GO:0071944,GO:0090630","GTPase activity|GTPase activator activity|GTP binding|nucleus|cytoplasm|polyubiquitin modification-dependent protein binding|cellular response to reactive oxygen species|proteasome-mediated ubiquitin-dependent protein catabolic process|metal ion binding|cell periphery|activation of GTPase activity"]
["AGAP4",0.895016819575392,1.50152224979248,1.38281283040165,1.2639038762036,1.45991673462002,1.2243014552035,1.00599621529133,1.23009311120698,1.75799895683673,1.52719354967323,1.54424249666215,1.28333458595829,1.44092840789327,1.40423144226108,1.31080415046878,1.41658049422095,1.15863198528666,1.49323784957578,1.17891375999283,1.88398007106092,1.56314443253526,1.21917998716051,1.09229799999592,1.24620200016708,1.38341268166639,1.33255878320578,1.18661332933862,1.21243893074921,119016,"ArfGAP with GTPase domain%2C ankyrin repeat and PH domain 4","protein_coding","hsa04144","Endocytosis","GO:0003924,GO:0005096,GO:0046872,GO:0090630","GTPase activity|GTPase activator activity|metal ion binding|activation of GTPase activity"]
["AGAP5",1.16985413672625,1.57478930527109,1.52645214785015,1.51179113882723,1.51125954247151,1.48956291678089,1.03596520883256,1.04993876681283,1.61548964515518,1.77601544835115,1.36123988758329,1.11712450471214,1.62164065029548,1.57845101990128,1.4844170025054,1.43819925425284,1.27725153524081,1.19250193238516,1.007902166902,1.53489834029794,1.54396489633049,1.50778233784688,1.65405681333612,1.38505856890307,1.73973083316651,1.52605626516817,1.60213341079647,1.60309574707011,729092,"ArfGAP with GTPase domain%2C ankyrin repeat and PH domain 5","protein_coding","hsa04144","Endocytosis","GO:0003924,GO:0005096,GO:0046872,GO:0090630","GTPase activity|GTPase activator activity|metal ion binding|activation of GTPase activity"]
["AGAP6",0.0803463941437946,0.219715409978266,0.141435132424459,0.173377953482745,0.284602789042906,0.0754493586201054,0.0374812300779187,0.137877991311672,0.171737359634616,0.183786705120885,0.0472257116542853,0.171774689899502,0.0477554427632462,0.16277595664014,0.0934021213774795,0.00952257330370599,0.0289680716377853,0.17656151074444,0.102104545149275,0.164183442677546,0.218025860817911,0.0859187350723059,0.168554105598012,0.127556369355353,0.209100362143892,0.171772933639355,0.116624594910329,0.254930310712184,414189,"ArfGAP with GTPase domain%2C ankyrin repeat and PH domain 6","protein_coding","hsa04144","Endocytosis","GO:0003924,GO:0005096,GO:0046872,GO:0090630","GTPase activity|GTPase activator activity|metal ion binding|activation of GTPase activity"]
["AGAP9",0.304909011877488,0.429657864433557,0.466496952905988,0.563189829439088,0.397259001899394,0.530231667721939,0.29501355287136,0.398657101936054,2.48765452681901,2.46897356857521,1.93290267570829,1.6474352205596,1.54648408933587,1.5934305628053,1.3337995102513,1.64894108046109,0.933741958905202,0.835915762728955,1.13765080971517,1.03165416136229,0.927319770275021,0.515248451186301,0.891888354912766,1.01502494834774,0.738940581954189,0.922806768942201,1.06001187109742,0.902415880554821,642517,"ArfGAP with GTPase domain%2C ankyrin repeat and PH domain 9","protein_coding","hsa04144","Endocytosis","GO:0003924,GO:0005096,GO:0046872,GO:0090630","GTPase activity|GTPase activator activity|metal ion binding|activation of GTPase activity"]
["AGBL2",0.110778966720177,0.210738353918404,0.356582602358276,0.172013247695384,0.180414238495786,0.0693513967590284,0.236241772671155,0.139666512082391,0.19102049772459,0.20322732167863,0.163713335915591,0.122067401368436,0.095316499379824,0.176023637236961,0.103023819360474,0.195065534860808,0.111579040708933,0.1269046087732,0.199893125180694,0.11160013725364,0.139411890514657,0.0752139220267675,0.124986546174761,0.149457738448642,0.0889090608880954,0.170420861406751,0.153141102122957,0.099185758346235,79841,"AGBL carboxypeptidase 2","protein_coding",null,null,"GO:0004181,GO:0005515,GO:0005814,GO:0005829,GO:0006508,GO:0008270,GO:0035610,GO:0036064","metallocarboxypeptidase activity|protein binding|centriole|cytosol|proteolysis|zinc ion binding|protein side chain deglutamylation|ciliary basal body",null,null,"R-HSA-392499,R-HSA-597592,R-HSA-8955332","Metabolism of proteins|Post-translational protein modification|Carboxyterminal post-translational modifications of tubulin"]
["AGBL3",0.0397291307814931,0.0692798240385158,0.0714899991388414,0.123833283241627,0.139110855966169,0.0373076784333756,0.0617782003986329,0.09414913264322,0.163178656708903,0.0573963677474836,0.0342493714291604,0.0899343146476305,0.100752136282232,0.0883793452499014,0.0769747278853952,0.0565038763754169,0.0636619211297926,0.0428866263799991,0.137694412397327,0.101878332572493,0.0906211533466992,0.110145009043538,0.150348693727173,0.0711595005734268,0.0984709569418197,0.0408956385309669,0.182614463339695,0.0560249696185623,340351,"AGBL carboxypeptidase 3","protein_coding",null,null,"GO:0004181,GO:0005829,GO:0006508,GO:0008270","metallocarboxypeptidase activity|cytosol|proteolysis|zinc ion binding",null,null,"R-HSA-392499,R-HSA-597592,R-HSA-8955332","Metabolism of proteins|Post-translational protein modification|Carboxyterminal post-translational modifications of tubulin"]
["AGBL4",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,2.47780773118244E-3,0,0,0,0,0,0,0,0,2.59088877498883E-3,0.00248310741578084,0,0,84871,"AGBL carboxypeptidase 4","protein_coding",null,null,"GO:0004181,GO:0005794,GO:0005814,GO:0005829,GO:0006508,GO:0008270,GO:0008285,GO:0015631,GO:0021954,GO:0035608,GO:0035609,GO:0035610,GO:0036064,GO:0051607,GO:0098957,GO:0098958,GO:0120222,GO:1904115,GO:2000060","metallocarboxypeptidase activity|Golgi apparatus|centriole|cytosol|proteolysis|zinc ion binding|negative regulation of cell population proliferation|tubulin binding|central nervous system neuron development|protein deglutamylation|C-terminal protein deglutamylation|protein side chain deglutamylation|ciliary basal body|defense response to virus|anterograde axonal transport of mitochondrion|retrograde axonal transport of mitochondrion|regulation of blastocyst development|axon cytoplasm|positive regulation of ubiquitin-dependent protein catabolic process",null,null,"R-HSA-392499,R-HSA-597592,R-HSA-8955332","Metabolism of proteins|Post-translational protein modification|Carboxyterminal post-translational modifications of tubulin"]
["AGBL5",8.60636813962269,9.39490988057248,9.88714375186859,9.54414217367823,8.90361925387147,9.56837033613708,10.0405467310577,10.4143962244372,7.93917422925098,9.49874808025327,10.2046078145546,8.60638027070653,7.59794756023128,8.38225822340597,8.9991746484107,7.82189999705901,10.0251518149958,9.82674349576443,11.5466249397869,9.8912569202031,10.2556337379841,10.4978202068445,11.1524159251057,10.1943810029708,9.79990999714174,10.7127942629069,11.6724595596894,11.1093792112948,60509,"AGBL carboxypeptidase 5","protein_coding",null,null,"GO:0004181,GO:0005634,GO:0005737,GO:0005829,GO:0006508,GO:0008270,GO:0015630,GO:0015631,GO:0030496,GO:0035608,GO:0035609,GO:0035610,GO:0035611,GO:0045171,GO:0051607,GO:0072686","metallocarboxypeptidase activity|nucleus|cytoplasm|cytosol|proteolysis|zinc ion binding|microtubule cytoskeleton|tubulin binding|midbody|protein deglutamylation|C-terminal protein deglutamylation|protein side chain deglutamylation|protein branching point deglutamylation|intercellular bridge|defense response to virus|mitotic spindle",null,null,"R-HSA-392499,R-HSA-597592,R-HSA-8955332","Metabolism of proteins|Post-translational protein modification|Carboxyterminal post-translational modifications of tubulin"]
["AGBL5-AS1",0,0.377982796954386,0.124360981302947,0.127039701651021,0.129437242360613,0,0,0,0.266479591420326,0,0,0.0666343789117306,0,0.0631436143405315,0.0615949124759595,0.1255950208705,0,0,0,0.0636896025648987,0,0.0629554695424704,0.13077011690275,0.0647063495274559,0,0,0.256363974397482,0.0622652610748477,100874031,"AGBL5 antisense RNA 1","non_coding"]
["AGER",1.21666387638553,2.1642063075325,2.26966080501637,2.57616557949418,1.45135111905989,1.7656963178361,1.82801188007218,2.54105605022638,1.46220132197284,2.93711725467637,3.53662447820213,2.16198484262726,1.57777712538546,2.80193311418928,1.86622475437858,2.17233005764144,1.76221869792782,2.54387149077021,2.10289876809198,2.33993957184215,2.23704601573197,2.35802552655001,2.05905444328351,1.65175663280842,1.4882043861846,2.22201725854593,2.20178484928013,2.02022668875438,177,"advanced glycosylation end-product specific receptor","protein_coding","hsa04613,hsa05010,hsa05022,hsa05417,hsa05415,hsa04933","Neutrophil extracellular trap formation|Alzheimer disease|Pathways of neurodegeneration - multiple diseases|Lipid and atherosclerosis|Diabetic cardiomyopathy|AGE-RAGE signaling pathway in diabetic complications","GO:0001540,GO:0001650,GO:0001666,GO:0001774,GO:0001914,GO:0001934,GO:0004888,GO:0005044,GO:0005055,GO:0005515,GO:0005576,GO:0005886,GO:0006897,GO:0006954,GO:0007155,GO:0007166,GO:0007611,GO:0009611,GO:0009986,GO:0010255,GO:0016324,GO:0030054,GO:0031175,GO:0032693,GO:0032722,GO:0032731,GO:0032735,GO:0032755,GO:0032760,GO:0034116,GO:0038023,GO:0042104,GO:0042802,GO:0044548,GO:0044877,GO:0045056,GO:0046330,GO:0048143,GO:0048167,GO:0050727,GO:0050785,GO:0050930,GO:0051092,GO:0060090,GO:0070374,GO:0071639,GO:0072657,GO:0098794,GO:0150003,GO:0150104,GO:1900271,GO:1900272,GO:1900453,GO:1900744,GO:1900745,GO:1901222,GO:1901224,GO:1902961,GO:1903523,GO:1904472,GO:1904645,GO:1904646,GO:2000439,GO:2000514,GO:2001200","amyloid-beta binding|fibrillar center|response to hypoxia|microglial cell activation|regulation of T cell mediated cytotoxicity|positive regulation of protein phosphorylation|transmembrane signaling receptor activity|scavenger receptor activity|laminin receptor activity|protein binding|extracellular region|plasma membrane|endocytosis|inflammatory response|cell adhesion|cell surface receptor signaling pathway|learning or memory|response to wounding|cell surface|glucose mediated signaling pathway|apical plasma membrane|cell junction|neuron projection development|negative regulation of interleukin-10 production|positive regulation of chemokine production|positive regulation of interleukin-1 beta production|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of tumor necrosis factor production|positive regulation of heterotypic cell-cell adhesion|signaling receptor activity|positive regulation of activated T cell proliferation|identical protein binding|S100 protein binding|protein-containing complex binding|transcytosis|positive regulation of JNK cascade|astrocyte activation|regulation of synaptic plasticity|regulation of inflammatory response|advanced glycation end-product receptor activity|induction of positive chemotaxis|positive regulation of NF-kappaB transcription factor activity|molecular adaptor activity|positive regulation of ERK1 and ERK2 cascade|positive regulation of monocyte chemotactic protein-1 production|protein localization to membrane|postsynapse|regulation of spontaneous synaptic transmission|transport across blood-brain barrier|regulation of long-term synaptic potentiation|negative regulation of long-term synaptic potentiation|negative regulation of long-term synaptic depression|regulation of p38MAPK cascade|positive regulation of p38MAPK cascade|regulation of non-canonical NF-kappaB signal transduction|positive regulation of non-canonical NF-kappaB signal transduction|positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process|negative regulation of blood circulation|positive regulation of endothelin production|response to amyloid-beta|cellular response to amyloid-beta|positive regulation of monocyte extravasation|regulation of CD4-positive, alpha-beta T cell activation|positive regulation of dendritic cell differentiation","WP5124,WP5323,WP5283,WP5331,WP2059,WP2882,WP2884,WP4478,WP4479,WP2324,WP5087","Alzheimer's disease|Fatty Acids and Lipoproteins Transport in Hepatocytes|Chronic hyperglycemia impairment of neuron function|Autophagy in pancreatic ductal adenocarcinoma|Alzheimer's disease and miRNA effects|Nuclear receptors meta-pathway|NRF2 pathway|LTF danger signal response pathway|Supression of HMGB1 mediated inflammation by THBD|AGE/RAGE pathway|Pleural mesothelioma","R-HSA-1280215,R-HSA-166016,R-HSA-166058,R-HSA-166166,R-HSA-168138,R-HSA-168142,R-HSA-168164,R-HSA-168176,R-HSA-168179,R-HSA-168181,R-HSA-168188,R-HSA-168249,R-HSA-168249,R-HSA-168256,R-HSA-168256,R-HSA-168898,R-HSA-168928,R-HSA-181438,R-HSA-445989,R-HSA-446652,R-HSA-449147,R-HSA-879415,R-HSA-879415,R-HSA-9020702,R-HSA-933542,R-HSA-937061,R-HSA-975138,R-HSA-975155,R-HSA-975871","Cytokine Signaling in Immune system|Toll Like Receptor 4 (TLR4) Cascade|MyD88:MAL(TIRAP) cascade initiated on plasma membrane|MyD88-independent TLR4 cascade |Toll Like Receptor 9 (TLR9) Cascade|Toll Like Receptor 10 (TLR10) Cascade|Toll Like Receptor 3 (TLR3) Cascade|Toll Like Receptor 5 (TLR5) Cascade|Toll Like Receptor TLR1:TLR2 Cascade|Toll Like Receptor 7/8 (TLR7/8) Cascade|Toll Like Receptor TLR6:TLR2 Cascade|Innate Immune System|Innate Immune System|Immune System|Immune System|Toll-like Receptor Cascades|DDX58/IFIH1-mediated induction of interferon-alpha/beta|Toll Like Receptor 2 (TLR2) Cascade|TAK1-dependent IKK and NF-kappa-B activation  |Interleukin-1 family signaling|Signaling by Interleukins|Advanced glycosylation endproduct receptor signaling|Advanced glycosylation endproduct receptor signaling|Interleukin-1 signaling|TRAF6 mediated NF-kB activation|TRIF(TICAM1)-mediated TLR4 signaling |TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation|MyD88 dependent cascade initiated on endosome|MyD88 cascade initiated on plasma membrane"]
["AGFG1",6.58114935906724,6.59678411455289,4.97239949890989,5.19770110458837,6.32243748117592,5.72579051067925,5.45312270090201,5.43226183047525,6.13937880716916,4.95268745969583,5.09970752636825,5.71913986061289,6.89736843338451,4.59411834738103,5.81383741083378,5.87476488153073,5.61051077450356,5.50489201251469,5.78059473120801,6.87669356430722,6.31922756327855,6.58656399101765,7.09929725170675,6.70051296806305,6.3994641800035,5.23155596066795,6.71132842873682,5.41076507360166,3267,"ArfGAP with FG repeats 1","protein_coding",null,null,"GO:0001675,GO:0003677,GO:0003723,GO:0005096,GO:0005515,GO:0005643,GO:0005737,GO:0005829,GO:0006406,GO:0007289,GO:0031410,GO:0043231,GO:0045109,GO:0046872","acrosome assembly|DNA binding|RNA binding|GTPase activator activity|protein binding|nuclear pore|cytoplasm|cytosol|mRNA export from nucleus|spermatid nucleus differentiation|cytoplasmic vesicle|intracellular membrane-bounded organelle|intermediate filament organization|metal ion binding",null,null,"R-HSA-199991,R-HSA-5653656,R-HSA-8856825,R-HSA-8856828","Membrane Trafficking|Vesicle-mediated transport|Cargo recognition for clathrin-mediated endocytosis|Clathrin-mediated endocytosis"]
["AGFG2",2.00993915540453,2.18063046219646,1.6806118865517,1.89752912040805,1.69295116301891,1.46964362821292,1.36249001973924,1.65784802723732,1.91116317068108,2.10218933468613,2.10682061026344,1.94317493749523,1.60779500992724,1.74157444888779,1.56742906012124,1.33500190970534,1.79152804674371,1.61757409990718,1.60123718144389,1.70630010382267,1.85262160331978,1.80106430088744,1.3331696015039,1.63126591809673,1.82145266361504,1.79541443315619,1.3219794130253,1.87973382531085,3268,"ArfGAP with FG repeats 2","protein_coding",null,null,"GO:0003674,GO:0005096,GO:0005737,GO:0008150,GO:0016020,GO:0046872","molecular_function|GTPase activator activity|cytoplasm|biological_process|membrane|metal ion binding"]
["AGGF1",10.818507762563,9.5763919914792,8.51097196874751,8.4524691295819,9.67968598076503,9.12179384943862,8.43558073624029,8.34793989292063,9.66814961729535,6.4182944949519,7.87623897825131,8.72195045912146,11.4587281074272,7.65832193473628,9.75965214972087,9.03942889854549,9.76640793130514,8.33239529078792,9.19413907354412,9.42186248865641,9.33842320516446,7.99502214285154,12.0730670767569,10.3054445079586,9.55910433155898,8.00913300740899,10.5850629549192,8.12748868836231,55109,"angiogenic factor with G-patch and FHA domains 1","protein_coding",null,null,"GO:0001525,GO:0001570,GO:0001938,GO:0003676,GO:0005515,GO:0005576,GO:0005737,GO:0007155,GO:0045766,GO:0048471","angiogenesis|vasculogenesis|positive regulation of endothelial cell proliferation|nucleic acid binding|protein binding|extracellular region|cytoplasm|cell adhesion|positive regulation of angiogenesis|perinuclear region of cytoplasm",null,null,"R-HSA-1643685,R-HSA-5663202,R-HSA-6802952,R-HSA-6802957","Disease|Diseases of signal transduction by growth factor receptors and second messengers|Signaling by BRAF and RAF1 fusions|Oncogenic MAPK signaling"]
["AGK",2.67258604137351,2.7008125511482,2.4627768590676,2.14837007843927,2.5357419443412,2.14549080416534,2.33779204198763,2.27729180786513,2.46601092251307,2.51970955296192,2.07793131278855,2.47600638745002,2.21971362256569,2.18718732226351,2.28437741539176,2.21977261947665,2.768402590916,2.3445312367386,2.89368625827307,2.59487924171721,2.97955230514617,2.5269857754954,3.37867653974688,3.32523379884136,2.91999016355549,2.62207525415914,3.23447147799181,2.57220464803688,55750,"acylglycerol kinase","protein_coding","hsa00561","Glycerolipid metabolism","GO:0001729,GO:0004143,GO:0005515,GO:0005524,GO:0005739,GO:0005741,GO:0005743,GO:0005758,GO:0005829,GO:0031966,GO:0042721,GO:0043231,GO:0045039,GO:0046486,GO:0046513,GO:0046834,GO:0047620,GO:0102773","ceramide kinase activity|ATP-dependent diacylglycerol kinase activity|protein binding|ATP binding|mitochondrion|mitochondrial outer membrane|mitochondrial inner membrane|mitochondrial intermembrane space|cytosol|mitochondrial membrane|TIM22 mitochondrial import inner membrane insertion complex|intracellular membrane-bounded organelle|protein insertion into mitochondrial inner membrane|glycerolipid metabolic process|ceramide biosynthetic process|lipid phosphorylation|acylglycerol kinase activity|dihydroceramide kinase activity",null,null,"R-HSA-1430728,R-HSA-1483206,R-HSA-1483257,R-HSA-1643685,R-HSA-556833,R-HSA-5663202,R-HSA-6802952,R-HSA-6802957","Metabolism|Glycerophospholipid biosynthesis|Phospholipid metabolism|Disease|Metabolism of lipids|Diseases of signal transduction by growth factor receptors and second messengers|Signaling by BRAF and RAF1 fusions|Oncogenic MAPK signaling"]
["AGK-DT",0,0.0210940625751316,0,0,0,0,0,0.0108733774660789,0.011153557559448,0,0.0364984233056648,0.0111559819897467,0,0.0105715553420799,0,0.0157704155165447,0,0.00512991291041242,0,5.33148256764989E-3,0,0.00527002799337422,0,0.00541659486994541,0,0.00526804874409285,0.0160952495238238,0.0156367510844074,105375538,null,"non_coding"]
["AGL",2.73005464517516,2.39955684790564,1.79118230115568,1.47931208375214,3.00072712317731,2.71213498039772,2.2717524022318,1.8708572831961,2.74253070638244,1.53973437261763,1.23581660505625,1.79575829591681,3.2411454672903,1.67153624442929,2.58794974806448,2.88500210154186,1.847819622822,1.75553750626037,1.51975002863477,1.85830520518151,1.8637618027419,1.91370020952412,2.93103524208872,2.47152615556904,1.96118156582215,1.41553952937467,2.29842065315198,1.26181298231893,178,"amylo-alpha-1%2C 6-glucosidase%2C 4-alpha-glucanotransferase","protein_coding","hsa00500","Starch and sucrose metabolism","GO:0004133,GO:0004134,GO:0004135,GO:0005515,GO:0005576,GO:0005634,GO:0005737,GO:0005829,GO:0005978,GO:0005980,GO:0007584,GO:0016234,GO:0016529,GO:0030247,GO:0031593,GO:0034774,GO:0043033,GO:0051384,GO:0102500,GO:1904813","glycogen debranching enzyme activity|4-alpha-glucanotransferase activity|amylo-alpha-1,6-glucosidase activity|protein binding|extracellular region|nucleus|cytoplasm|cytosol|glycogen biosynthetic process|glycogen catabolic process|response to nutrient|inclusion body|sarcoplasmic reticulum|polysaccharide binding|polyubiquitin modification-dependent protein binding|secretory granule lumen|isoamylase complex|response to glucocorticoid|beta-maltose 4-alpha-glucanotransferase activity|ficolin-1-rich granule lumen","WP500","Glycogen synthesis and degradation","R-HSA-1430728,R-HSA-168249,R-HSA-168256,R-HSA-6798695,R-HSA-70221,R-HSA-71387,R-HSA-8982491","Metabolism|Innate Immune System|Immune System|Neutrophil degranulation|Glycogen breakdown (glycogenolysis)|Metabolism of carbohydrates|Glycogen metabolism"]
["AGMAT",1.07999052961878,0.795290460021636,1.02211065004644,0.60977004454822,0.706384407784149,0.899663515306943,0.658204308873977,0.879682586062648,0.262820340164958,0.402646183047936,0.393162060345388,0.473179444175126,0.231917094316218,0.307230917077242,0.356394731056375,0.289030867899884,0.586162767830598,0.757516587276242,0.692265517096087,0.711903651286808,0.772733758248449,0.629188556991177,0.713658371420324,0.748795675177823,0.811680667242949,0.653779317127165,0.750102766122778,0.515846061137373,79814,"agmatinase","protein_coding","hsa00330","Arginine and proline metabolism","GO:0000050,GO:0004053,GO:0005739,GO:0008783,GO:0033389,GO:0046872,GO:0047971,GO:0047972,GO:0097055","urea cycle|arginase activity|mitochondrion|agmatinase activity|putrescine biosynthetic process from arginine, using agmatinase|metal ion binding|guanidinobutyrase activity|guanidinopropionase activity|agmatine biosynthetic process",null,null,"R-HSA-1430728,R-HSA-351143,R-HSA-351202,R-HSA-71291","Metabolism|Agmatine biosynthesis|Metabolism of polyamines|Metabolism of amino acids and derivatives"]
["AGMO",0,0,0,3.27496570635707E-3,0,0.0128265821216343,0,0,0,0.0065777274751571,0,0,0,0,0.00317571945499309,0,0,0.00315956885868066,0,0,0,0.00649173450817974,0.00674226470476556,0.00333613937898082,0.00338548488903089,0.00324464821304528,0.00660882553710255,3.2102813855413E-3,392636,"alkylglycerol monooxygenase","protein_coding",null,null,"GO:0005506,GO:0005515,GO:0005783,GO:0005789,GO:0006643,GO:0019432,GO:0046485,GO:0050479","iron ion binding|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|membrane lipid metabolic process|triglyceride biosynthetic process|ether lipid metabolic process|glyceryl-ether monooxygenase activity",null,null,"R-HSA-1430728,R-HSA-556833,R-HSA-75109,R-HSA-8979227","Metabolism|Metabolism of lipids|Triglyceride biosynthesis|Triglyceride metabolism"]
["AGO1",3.09744133902179,3.21917869705212,3.34925077571942,2.87271407672597,3.0850396446056,3.19626483469481,3.44701432922821,3.07323030361594,3.50699443710897,3.33943994712027,3.34592378473557,3.49612882375319,3.51718119312536,3.1385137788726,3.53626278345079,3.56329875258565,3.20209318500513,3.27231990448054,2.81465326246712,3.39719448044432,3.20351469010618,3.12183819901059,3.02552841177848,3.34604051808956,3.45855417179304,2.78938098917535,3.19492274924493,2.92100782537429,26523,"argonaute RISC component 1","protein_coding",null,null,"GO:0000932,GO:0000956,GO:0000993,GO:0001046,GO:0003723,GO:0003725,GO:0003727,GO:0004521,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005844,GO:0010501,GO:0016442,GO:0016525,GO:0031054,GO:0035196,GO:0035198,GO:0035278,GO:0035279,GO:0036464,GO:0045944,GO:0070578,GO:0070922,GO:0090625,GO:1990904","P-body|nuclear-transcribed mRNA catabolic process|RNA polymerase II complex binding|core promoter sequence-specific DNA binding|RNA binding|double-stranded RNA binding|single-stranded RNA binding|RNA endonuclease activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|polysome|RNA secondary structure unwinding|RISC complex|negative regulation of angiogenesis|pre-miRNA processing|miRNA processing|miRNA binding|miRNA-mediated gene silencing by inhibition of translation|miRNA-mediated gene silencing by mRNA destabilization|cytoplasmic ribonucleoprotein granule|positive regulation of transcription by RNA polymerase II|RISC-loading complex|RISC complex assembly|siRNA-mediated gene silencing by mRNA destabilization|ribonucleoprotein complex","WP5072","Modulators of TCR signaling and T cell activation","R-HSA-1257604,R-HSA-1500931,R-HSA-1500931,R-HSA-157118,R-HSA-162582,R-HSA-1912408,R-HSA-1912422,R-HSA-195721,R-HSA-203927,R-HSA-211000,R-HSA-212436,R-HSA-212436,R-HSA-2262752,R-HSA-2559580,R-HSA-2559583,R-HSA-2559585,R-HSA-3700989,R-HSA-3858494,R-HSA-4086398,R-HSA-418990,R-HSA-418990,R-HSA-421270,R-HSA-421270,R-HSA-426486,R-HSA-426496,R-HSA-446728,R-HSA-446728,R-HSA-5578749,R-HSA-5628897,R-HSA-5683057,R-HSA-5687128,R-HSA-6807070,R-HSA-73857,R-HSA-73857,R-HSA-74160,R-HSA-74160,R-HSA-8853884,R-HSA-8878171,R-HSA-8934593,R-HSA-8936459,R-HSA-8939211,R-HSA-8943723,R-HSA-8948700,R-HSA-8953897,R-HSA-8986944,R-HSA-8986944,R-HSA-9006925,R-HSA-9006931,R-HSA-9018519,R-HSA-9022692,R-HSA-9024446,R-HSA-9029569,R-HSA-9634815,R-HSA-9759475,R-HSA-9759475,R-HSA-9759476,R-HSA-9759476,R-HSA-9759811,R-HSA-9759811,R-HSA-9764260,R-HSA-9764260,R-HSA-9768759,R-HSA-9768778","PIP3 activates AKT signaling|Cell-Cell communication|Cell-Cell communication|Signaling by NOTCH|Signal Transduction|Pre-NOTCH Transcription and Translation|Pre-NOTCH Expression and Processing|Signaling by WNT|MicroRNA (miRNA) biogenesis|Gene Silencing by RNA|Generic Transcription Pathway|Generic Transcription Pathway|Cellular responses to stress|Oxidative Stress Induced Senescence|Cellular Senescence|Oncogene Induced Senescence|Transcriptional Regulation by TP53|Beta-catenin independent WNT signaling|Ca2+ pathway|Adherens junctions interactions|Adherens junctions interactions|Cell-cell junction organization|Cell-cell junction organization|Small interfering RNA (siRNA) biogenesis|Post-transcriptional silencing by small RNAs|Cell junction organization|Cell junction organization|Transcriptional regulation by small RNAs|TP53 Regulates Metabolic Genes|MAPK family signaling cascades|MAPK6/MAPK4 signaling|PTEN Regulation|RNA Polymerase II Transcription|RNA Polymerase II Transcription|Gene expression (Transcription)|Gene expression (Transcription)|Transcriptional Regulation by VENTX|Transcriptional regulation by RUNX1|Regulation of RUNX1 Expression and Activity|RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function|ESR-mediated signaling|Regulation of PTEN mRNA translation|Competing endogenous RNAs (ceRNAs) regulate PTEN translation|Cellular responses to stimuli|Transcriptional Regulation by MECP2|Transcriptional Regulation by MECP2|Intracellular signaling by second messengers|Signaling by Nuclear Receptors|Estrogen-dependent gene expression|Regulation of MECP2 expression and activity|NR1H2 and NR1H3-mediated signaling|NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux|Transcriptional Regulation by NPAS4|Regulation of CDH11 Expression and Function|Regulation of CDH11 Expression and Function|Regulation of Homotypic Cell-Cell Adhesion|Regulation of Homotypic Cell-Cell Adhesion|Regulation of CDH11 mRNA translation by microRNAs|Regulation of CDH11 mRNA translation by microRNAs|Regulation of Expression and Function of Type II Classical Cadherins|Regulation of Expression and Function of Type II Classical Cadherins|Regulation of NPAS4 gene expression|Regulation of NPAS4 mRNA translation"]
["AGO2",2.6671320294895,2.5246295869868,2.08464974173761,1.9318380718773,2.70833113793961,2.0716837526192,1.92073736999966,1.85729980138669,2.69573353100951,2.3812669512378,2.01685917998823,2.30310623798937,2.48059863468138,2.02139715254125,2.36724797034246,2.32252068215881,2.25046023847892,1.98033600683975,1.54146465580397,2.27428944388685,2.27685479748731,2.17050758858876,1.89528466179832,2.24765644495634,2.31496648210473,1.78064412177265,1.65412560770953,1.9138705671099,27161,"argonaute RISC catalytic component 2","protein_coding",null,null,"GO:0000340,GO:0000932,GO:0000993,GO:0001046,GO:0003723,GO:0003725,GO:0003727,GO:0003743,GO:0004521,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005844,GO:0005845,GO:0006412,GO:0006413,GO:0009791,GO:0010501,GO:0010586,GO:0016020,GO:0016442,GO:0030422,GO:0030425,GO:0031047,GO:0031054,GO:0035194,GO:0035196,GO:0035197,GO:0035198,GO:0035278,GO:0035279,GO:0035925,GO:0036464,GO:0042985,GO:0045727,GO:0045766,GO:0045944,GO:0045947,GO:0046872,GO:0060213,GO:0070062,GO:0070551,GO:0070578,GO:0070922,GO:0090624,GO:0090625,GO:0098808,GO:1900153,GO:1901165,GO:1990904","RNA 7-methylguanosine cap binding|P-body|RNA polymerase II complex binding|core promoter sequence-specific DNA binding|RNA binding|double-stranded RNA binding|single-stranded RNA binding|translation initiation factor activity|RNA endonuclease activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|polysome|mRNA cap binding complex|translation|translational initiation|post-embryonic development|RNA secondary structure unwinding|miRNA metabolic process|membrane|RISC complex|siRNA processing|dendrite|regulatory ncRNA-mediated gene silencing|pre-miRNA processing|regulatory ncRNA-mediated post-transcriptional gene silencing|miRNA processing|siRNA binding|miRNA binding|miRNA-mediated gene silencing by inhibition of translation|miRNA-mediated gene silencing by mRNA destabilization|mRNA 3'-UTR AU-rich region binding|cytoplasmic ribonucleoprotein granule|negative regulation of amyloid precursor protein biosynthetic process|positive regulation of translation|positive regulation of angiogenesis|positive regulation of transcription by RNA polymerase II|negative regulation of translational initiation|metal ion binding|positive regulation of nuclear-transcribed mRNA poly(A) tail shortening|extracellular exosome|endoribonuclease activity, cleaving siRNA-paired mRNA|RISC-loading complex|RISC complex assembly|endoribonuclease activity, cleaving miRNA-paired mRNA|siRNA-mediated gene silencing by mRNA destabilization|mRNA cap binding|positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|positive regulation of trophoblast cell migration|ribonucleoprotein complex","WP4549,WP4844,WP4879,WP2805,WP4673","Fragile X syndrome|Influence of laminopathies on Wnt signaling|Overlap between signal transduction pathways contributing to LMNA laminopathies|exRNA mechanism of action and biogenesis|Male infertility","R-HSA-1257604,R-HSA-1500931,R-HSA-1500931,R-HSA-157118,R-HSA-162582,R-HSA-1912408,R-HSA-1912422,R-HSA-195721,R-HSA-203927,R-HSA-211000,R-HSA-212436,R-HSA-212436,R-HSA-3700989,R-HSA-3858494,R-HSA-4086398,R-HSA-418990,R-HSA-418990,R-HSA-421270,R-HSA-421270,R-HSA-426486,R-HSA-426496,R-HSA-446728,R-HSA-446728,R-HSA-5578749,R-HSA-5628897,R-HSA-5683057,R-HSA-5687128,R-HSA-6807070,R-HSA-73857,R-HSA-73857,R-HSA-74160,R-HSA-74160,R-HSA-8878171,R-HSA-8934593,R-HSA-8939211,R-HSA-8943723,R-HSA-8948700,R-HSA-8986944,R-HSA-8986944,R-HSA-9006925,R-HSA-9006931,R-HSA-9018519,R-HSA-9022692,R-HSA-9024446,R-HSA-9029569,R-HSA-9634815,R-HSA-9759475,R-HSA-9759475,R-HSA-9759476,R-HSA-9759476,R-HSA-9759811,R-HSA-9759811,R-HSA-9764260,R-HSA-9764260,R-HSA-9768759,R-HSA-9768778","PIP3 activates AKT signaling|Cell-Cell communication|Cell-Cell communication|Signaling by NOTCH|Signal Transduction|Pre-NOTCH Transcription and Translation|Pre-NOTCH Expression and Processing|Signaling by WNT|MicroRNA (miRNA) biogenesis|Gene Silencing by RNA|Generic Transcription Pathway|Generic Transcription Pathway|Transcriptional Regulation by TP53|Beta-catenin independent WNT signaling|Ca2+ pathway|Adherens junctions interactions|Adherens junctions interactions|Cell-cell junction organization|Cell-cell junction organization|Small interfering RNA (siRNA) biogenesis|Post-transcriptional silencing by small RNAs|Cell junction organization|Cell junction organization|Transcriptional regulation by small RNAs|TP53 Regulates Metabolic Genes|MAPK family signaling cascades|MAPK6/MAPK4 signaling|PTEN Regulation|RNA Polymerase II Transcription|RNA Polymerase II Transcription|Gene expression (Transcription)|Gene expression (Transcription)|Transcriptional regulation by RUNX1|Regulation of RUNX1 Expression and Activity|ESR-mediated signaling|Regulation of PTEN mRNA translation|Competing endogenous RNAs (ceRNAs) regulate PTEN translation|Transcriptional Regulation by MECP2|Transcriptional Regulation by MECP2|Intracellular signaling by second messengers|Signaling by Nuclear Receptors|Estrogen-dependent gene expression|Regulation of MECP2 expression and activity|NR1H2 and NR1H3-mediated signaling|NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux|Transcriptional Regulation by NPAS4|Regulation of CDH11 Expression and Function|Regulation of CDH11 Expression and Function|Regulation of Homotypic Cell-Cell Adhesion|Regulation of Homotypic Cell-Cell Adhesion|Regulation of CDH11 mRNA translation by microRNAs|Regulation of CDH11 mRNA translation by microRNAs|Regulation of Expression and Function of Type II Classical Cadherins|Regulation of Expression and Function of Type II Classical Cadherins|Regulation of NPAS4 gene expression|Regulation of NPAS4 mRNA translation"]
["AGO3",0.819481269074121,0.931508242135311,0.768454282887772,0.703735412993208,0.911796662628261,0.716182680495121,0.667537587934005,0.684601720055993,0.872717568061422,0.587079976709667,0.646606082929251,0.731459476436649,0.784814034785166,0.66376247988637,0.791666144032455,0.790688247884443,0.622157973699951,0.641516748140826,0.552684210309676,0.754694374264627,0.598052258509365,0.601372828928198,0.747215767110056,0.658551744377959,0.62246674345495,0.578272278500647,0.616878961506548,0.515113633961936,192669,"argonaute RISC catalytic component 3","protein_coding",null,null,"GO:0000794,GO:0000932,GO:0003723,GO:0003725,GO:0003727,GO:0004521,GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0006402,GO:0010501,GO:0010628,GO:0016020,GO:0016442,GO:0031054,GO:0035196,GO:0035198,GO:0035278,GO:0035279,GO:0036464,GO:0046872,GO:0070578,GO:0070922,GO:0072091,GO:0090624,GO:0090625,GO:1901224","condensed nuclear chromosome|P-body|RNA binding|double-stranded RNA binding|single-stranded RNA binding|RNA endonuclease activity|protein binding|nucleoplasm|cytoplasm|cytosol|mRNA catabolic process|RNA secondary structure unwinding|positive regulation of gene expression|membrane|RISC complex|pre-miRNA processing|miRNA processing|miRNA binding|miRNA-mediated gene silencing by inhibition of translation|miRNA-mediated gene silencing by mRNA destabilization|cytoplasmic ribonucleoprotein granule|metal ion binding|RISC-loading complex|RISC complex assembly|regulation of stem cell proliferation|endoribonuclease activity, cleaving miRNA-paired mRNA|siRNA-mediated gene silencing by mRNA destabilization|positive regulation of non-canonical NF-kappaB signal transduction",null,null,"R-HSA-1257604,R-HSA-1500931,R-HSA-1500931,R-HSA-157118,R-HSA-162582,R-HSA-1912408,R-HSA-1912422,R-HSA-195721,R-HSA-203927,R-HSA-211000,R-HSA-212436,R-HSA-212436,R-HSA-2262752,R-HSA-2559580,R-HSA-2559583,R-HSA-2559585,R-HSA-3700989,R-HSA-3858494,R-HSA-4086398,R-HSA-418990,R-HSA-418990,R-HSA-421270,R-HSA-421270,R-HSA-426486,R-HSA-426496,R-HSA-446728,R-HSA-446728,R-HSA-5628897,R-HSA-5683057,R-HSA-5687128,R-HSA-6807070,R-HSA-73857,R-HSA-73857,R-HSA-74160,R-HSA-74160,R-HSA-8853884,R-HSA-8878171,R-HSA-8934593,R-HSA-8936459,R-HSA-8939211,R-HSA-8943723,R-HSA-8948700,R-HSA-8953897,R-HSA-8986944,R-HSA-8986944,R-HSA-9006925,R-HSA-9006931,R-HSA-9018519,R-HSA-9022692,R-HSA-9024446,R-HSA-9029569,R-HSA-9634815,R-HSA-9759475,R-HSA-9759475,R-HSA-9759476,R-HSA-9759476,R-HSA-9759811,R-HSA-9759811,R-HSA-9764260,R-HSA-9764260,R-HSA-9768759,R-HSA-9768778","PIP3 activates AKT signaling|Cell-Cell communication|Cell-Cell communication|Signaling by NOTCH|Signal Transduction|Pre-NOTCH Transcription and Translation|Pre-NOTCH Expression and Processing|Signaling by WNT|MicroRNA (miRNA) biogenesis|Gene Silencing by RNA|Generic Transcription Pathway|Generic Transcription Pathway|Cellular responses to stress|Oxidative Stress Induced Senescence|Cellular Senescence|Oncogene Induced Senescence|Transcriptional Regulation by TP53|Beta-catenin independent WNT signaling|Ca2+ pathway|Adherens junctions interactions|Adherens junctions interactions|Cell-cell junction organization|Cell-cell junction organization|Small interfering RNA (siRNA) biogenesis|Post-transcriptional silencing by small RNAs|Cell junction organization|Cell junction organization|TP53 Regulates Metabolic Genes|MAPK family signaling cascades|MAPK6/MAPK4 signaling|PTEN Regulation|RNA Polymerase II Transcription|RNA Polymerase II Transcription|Gene expression (Transcription)|Gene expression (Transcription)|Transcriptional Regulation by VENTX|Transcriptional regulation by RUNX1|Regulation of RUNX1 Expression and Activity|RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function|ESR-mediated signaling|Regulation of PTEN mRNA translation|Competing endogenous RNAs (ceRNAs) regulate PTEN translation|Cellular responses to stimuli|Transcriptional Regulation by MECP2|Transcriptional Regulation by MECP2|Intracellular signaling by second messengers|Signaling by Nuclear Receptors|Estrogen-dependent gene expression|Regulation of MECP2 expression and activity|NR1H2 and NR1H3-mediated signaling|NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux|Transcriptional Regulation by NPAS4|Regulation of CDH11 Expression and Function|Regulation of CDH11 Expression and Function|Regulation of Homotypic Cell-Cell Adhesion|Regulation of Homotypic Cell-Cell Adhesion|Regulation of CDH11 mRNA translation by microRNAs|Regulation of CDH11 mRNA translation by microRNAs|Regulation of Expression and Function of Type II Classical Cadherins|Regulation of Expression and Function of Type II Classical Cadherins|Regulation of NPAS4 gene expression|Regulation of NPAS4 mRNA translation"]
["AGO4",3.82659206809444,3.92281357543696,3.42059088818211,3.44094630875068,4.30805210505687,3.65786125237819,3.60679303104332,3.2039247075246,4.36881682978405,3.4492487172006,3.39876146902481,3.79722176880657,4.39485888464133,4.15955686518072,4.1579106842195,4.44685918410685,3.17277590448508,3.14418349874687,2.72652088483543,3.41869126196727,3.12708380601444,2.95337688650766,3.051210174263,3.14734918633941,3.6284026719215,2.50165841543223,3.07310948768386,2.7057663075185,192670,"argonaute RISC component 4","protein_coding",null,null,"GO:0000932,GO:0003725,GO:0003727,GO:0004521,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0006402,GO:0007130,GO:0007140,GO:0008584,GO:0010501,GO:0010586,GO:0016020,GO:0016442,GO:0022604,GO:0031054,GO:0035196,GO:0035198,GO:0035278,GO:0035279,GO:0036464,GO:0043066,GO:0070578,GO:0070922,GO:0090625","P-body|double-stranded RNA binding|single-stranded RNA binding|RNA endonuclease activity|protein binding|nucleus|cytoplasm|cytosol|mRNA catabolic process|synaptonemal complex assembly|male meiotic nuclear division|male gonad development|RNA secondary structure unwinding|miRNA metabolic process|membrane|RISC complex|regulation of cell morphogenesis|pre-miRNA processing|miRNA processing|miRNA binding|miRNA-mediated gene silencing by inhibition of translation|miRNA-mediated gene silencing by mRNA destabilization|cytoplasmic ribonucleoprotein granule|negative regulation of apoptotic process|RISC-loading complex|RISC complex assembly|siRNA-mediated gene silencing by mRNA destabilization",null,null,"R-HSA-1257604,R-HSA-1500931,R-HSA-1500931,R-HSA-157118,R-HSA-162582,R-HSA-1912408,R-HSA-1912422,R-HSA-195721,R-HSA-203927,R-HSA-211000,R-HSA-212436,R-HSA-212436,R-HSA-2262752,R-HSA-2559580,R-HSA-2559583,R-HSA-2559585,R-HSA-3700989,R-HSA-3858494,R-HSA-4086398,R-HSA-418990,R-HSA-418990,R-HSA-421270,R-HSA-421270,R-HSA-426486,R-HSA-426496,R-HSA-446728,R-HSA-446728,R-HSA-5628897,R-HSA-5683057,R-HSA-5687128,R-HSA-6807070,R-HSA-73857,R-HSA-73857,R-HSA-74160,R-HSA-74160,R-HSA-8853884,R-HSA-8878171,R-HSA-8934593,R-HSA-8936459,R-HSA-8939211,R-HSA-8943723,R-HSA-8948700,R-HSA-8953897,R-HSA-8986944,R-HSA-8986944,R-HSA-9006925,R-HSA-9006931,R-HSA-9018519,R-HSA-9022692,R-HSA-9024446,R-HSA-9029569,R-HSA-9634815,R-HSA-9759475,R-HSA-9759475,R-HSA-9759476,R-HSA-9759476,R-HSA-9759811,R-HSA-9759811,R-HSA-9764260,R-HSA-9764260,R-HSA-9768759,R-HSA-9768778","PIP3 activates AKT signaling|Cell-Cell communication|Cell-Cell communication|Signaling by NOTCH|Signal Transduction|Pre-NOTCH Transcription and Translation|Pre-NOTCH Expression and Processing|Signaling by WNT|MicroRNA (miRNA) biogenesis|Gene Silencing by RNA|Generic Transcription Pathway|Generic Transcription Pathway|Cellular responses to stress|Oxidative Stress Induced Senescence|Cellular Senescence|Oncogene Induced Senescence|Transcriptional Regulation by TP53|Beta-catenin independent WNT signaling|Ca2+ pathway|Adherens junctions interactions|Adherens junctions interactions|Cell-cell junction organization|Cell-cell junction organization|Small interfering RNA (siRNA) biogenesis|Post-transcriptional silencing by small RNAs|Cell junction organization|Cell junction organization|TP53 Regulates Metabolic Genes|MAPK family signaling cascades|MAPK6/MAPK4 signaling|PTEN Regulation|RNA Polymerase II Transcription|RNA Polymerase II Transcription|Gene expression (Transcription)|Gene expression (Transcription)|Transcriptional Regulation by VENTX|Transcriptional regulation by RUNX1|Regulation of RUNX1 Expression and Activity|RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function|ESR-mediated signaling|Regulation of PTEN mRNA translation|Competing endogenous RNAs (ceRNAs) regulate PTEN translation|Cellular responses to stimuli|Transcriptional Regulation by MECP2|Transcriptional Regulation by MECP2|Intracellular signaling by second messengers|Signaling by Nuclear Receptors|Estrogen-dependent gene expression|Regulation of MECP2 expression and activity|NR1H2 and NR1H3-mediated signaling|NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux|Transcriptional Regulation by NPAS4|Regulation of CDH11 Expression and Function|Regulation of CDH11 Expression and Function|Regulation of Homotypic Cell-Cell Adhesion|Regulation of Homotypic Cell-Cell Adhesion|Regulation of CDH11 mRNA translation by microRNAs|Regulation of CDH11 mRNA translation by microRNAs|Regulation of Expression and Function of Type II Classical Cadherins|Regulation of Expression and Function of Type II Classical Cadherins|Regulation of NPAS4 gene expression|Regulation of NPAS4 mRNA translation"]
["AGPAT1",33.2855043129288,39.1752984079686,39.5907468944705,43.0070191739065,33.5436593397105,39.3393473427359,37.2111945865092,37.6180344090591,36.3214923737044,52.9527100539492,43.8401391147018,41.2426496547152,31.6702064476396,37.7758690946414,34.6449583417633,35.1779238858454,35.3153341321395,40.6127926943437,40.2562531097925,38.2641650971898,36.7637458271588,39.1493897438567,32.7522463557792,33.249883305059,33.3000220720871,41.8501545642046,34.6824404926848,40.3717119003363,10554,"1-acylglycerol-3-phosphate O-acyltransferase 1","protein_coding","hsa00561,hsa00564,hsa04072,hsa04975","Glycerolipid metabolism|Glycerophospholipid metabolism|Phospholipase D signaling pathway|Fat digestion and absorption","GO:0001819,GO:0001961,GO:0003841,GO:0005515,GO:0005783,GO:0005789,GO:0006644,GO:0006654,GO:0016020,GO:0016024","positive regulation of cytokine production|positive regulation of cytokine-mediated signaling pathway|1-acylglycerol-3-phosphate O-acyltransferase activity|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|phospholipid metabolic process|phosphatidic acid biosynthetic process|membrane|CDP-diacylglycerol biosynthetic process","WP325","Triacylglyceride synthesis","R-HSA-1430728,R-HSA-1483166,R-HSA-1483206,R-HSA-1483257,R-HSA-163685,R-HSA-163765,R-HSA-556833","Metabolism|Synthesis of PA|Glycerophospholipid biosynthesis|Phospholipid metabolism|Integration of energy metabolism|ChREBP activates metabolic gene expression|Metabolism of lipids"]
["AGPAT2",25.4218381714,28.4094657386185,30.0382849551099,34.0464756961584,26.0678736062023,30.7328516666197,30.5833260793615,30.9469967155682,22.3614039420751,28.9682735085173,30.9423595887648,26.4185054844204,20.0305478549645,29.0573353246898,22.1665587705932,22.9795831685214,26.5202633385814,32.4596201679789,31.8267660462067,30.3146029657154,31.5976238268667,33.0147278128982,22.2911874726222,26.23327668617,25.8434032874804,32.1076871293302,24.7352266642869,33.1281395222075,10555,"1-acylglycerol-3-phosphate O-acyltransferase 2","protein_coding","hsa00561,hsa00564,hsa04072,hsa04975","Glycerolipid metabolism|Glycerophospholipid metabolism|Phospholipase D signaling pathway|Fat digestion and absorption","GO:0001819,GO:0001961,GO:0003841,GO:0005783,GO:0005789,GO:0005886,GO:0006644,GO:0006654,GO:0008544,GO:0009410,GO:0016024,GO:0019432,GO:0035579","positive regulation of cytokine production|positive regulation of cytokine-mediated signaling pathway|1-acylglycerol-3-phosphate O-acyltransferase activity|endoplasmic reticulum|endoplasmic reticulum membrane|plasma membrane|phospholipid metabolic process|phosphatidic acid biosynthetic process|epidermis development|response to xenobiotic stimulus|CDP-diacylglycerol biosynthetic process|triglyceride biosynthetic process|specific granule membrane","WP5101,WP236,WP4352,WP325","Congenital generalized lipodystrophy|Adipogenesis|Ciliary landscape|Triacylglyceride synthesis","R-HSA-1430728,R-HSA-1483166,R-HSA-1483206,R-HSA-1483257,R-HSA-168249,R-HSA-168256,R-HSA-556833,R-HSA-6798695","Metabolism|Synthesis of PA|Glycerophospholipid biosynthesis|Phospholipid metabolism|Innate Immune System|Immune System|Metabolism of lipids|Neutrophil degranulation"]
["AGPAT3",13.9304476441775,14.5331891370447,14.4871983403606,13.3886850522463,13.6360678137683,14.1573155287052,14.6724628868104,13.7610840828392,12.3093247883107,14.3742182272801,14.0127152180594,13.0423271654861,12.5522455711202,14.1615544096356,15.1518100087378,14.1352955643384,15.0130795870202,15.4481760269394,14.1515340102331,15.6097827357089,14.8867230225281,15.2264559161763,13.1079828684844,13.6520059571285,14.9871708060579,14.8835854163009,13.3885003707167,14.6189911152627,56894,"1-acylglycerol-3-phosphate O-acyltransferase 3","protein_coding","hsa00561,hsa00564,hsa04072","Glycerolipid metabolism|Glycerophospholipid metabolism|Phospholipase D signaling pathway","GO:0000139,GO:0003841,GO:0005515,GO:0005635,GO:0005783,GO:0005789,GO:0005886,GO:0006654,GO:0008654,GO:0012505,GO:0016020,GO:0016024","Golgi membrane|1-acylglycerol-3-phosphate O-acyltransferase activity|protein binding|nuclear envelope|endoplasmic reticulum|endoplasmic reticulum membrane|plasma membrane|phosphatidic acid biosynthetic process|phospholipid biosynthetic process|endomembrane system|membrane|CDP-diacylglycerol biosynthetic process","WP325","Triacylglyceride synthesis","R-HSA-1430728,R-HSA-1483166,R-HSA-1483206,R-HSA-1483257,R-HSA-199991,R-HSA-556833,R-HSA-5653656,R-HSA-6811436,R-HSA-6811442,R-HSA-8856688","Metabolism|Synthesis of PA|Glycerophospholipid biosynthesis|Phospholipid metabolism|Membrane Trafficking|Metabolism of lipids|Vesicle-mediated transport|COPI-independent Golgi-to-ER retrograde traffic|Intra-Golgi and retrograde Golgi-to-ER traffic|Golgi-to-ER retrograde transport"]
["AGPAT4",2.79304561460518,3.26388401603489,3.07173311212871,2.59259244597311,2.6675136439541,2.67901528592881,2.74548738908608,2.68016214008524,2.03348876817898,2.09440457447478,1.94813429579137,2.21792123349208,2.1944954289707,2.434584728766,2.56350169657409,2.36449242140868,1.82859150716527,2.1628186146551,1.97292127649483,2.02078380783933,2.04934791197212,1.92479727978356,1.88747234539078,1.9393467499484,2.27131333476659,1.74082920927254,2.01743142538914,1.79741306562739,56895,"1-acylglycerol-3-phosphate O-acyltransferase 4","protein_coding","hsa00561,hsa00564,hsa04072","Glycerolipid metabolism|Glycerophospholipid metabolism|Phospholipase D signaling pathway","GO:0003841,GO:0005515,GO:0005741,GO:0005783,GO:0005789,GO:0006654,GO:0008654,GO:0012505,GO:0016024","1-acylglycerol-3-phosphate O-acyltransferase activity|protein binding|mitochondrial outer membrane|endoplasmic reticulum|endoplasmic reticulum membrane|phosphatidic acid biosynthetic process|phospholipid biosynthetic process|endomembrane system|CDP-diacylglycerol biosynthetic process","WP325,WP4722","Triacylglyceride synthesis|Glycerolipids and glycerophospholipids","R-HSA-1430728,R-HSA-1483166,R-HSA-1483206,R-HSA-1483257,R-HSA-556833","Metabolism|Synthesis of PA|Glycerophospholipid biosynthesis|Phospholipid metabolism|Metabolism of lipids"]
["AGPAT4-IT1",0.0432684032668428,0.0274369535153264,0.162487702697591,0.0829938339838933,0.126840186936042,0,0,0.141429537827917,0.116059062287932,0.0555640242791762,0.0542552424098884,0.188636971012288,0.150875515478018,0.0275007501729228,0.107304994661168,0.164100075423094,0.041599948783208,0.133449098825175,0.0266597207238342,0.0554770855942509,0.0408389566916934,0.137094040148664,0.0996693587629576,0.0281813635716154,0.243084698308275,0.109634041706921,0.125610117471639,0.0271182035927908,79992,"AGPAT4 intronic transcript 1","non_coding"]
["AGPAT5",6.08705162625009,4.92738288399353,3.49101390352596,3.88374915577405,4.89279869244866,3.80272894076928,3.59284362604049,3.50144739505792,3.8581002863841,2.82582752048381,2.89818802337345,3.94605971412457,4.39846758903666,2.42328534906681,3.69025921867732,3.26968314962555,4.515355287371,4.34546275849055,4.10988158944395,5.05501920402853,4.94718583701319,4.57067177663897,5.45107769615368,4.94661212247327,4.32791764567393,4.18659558571792,4.33764744284779,3.86929416024757,55326,"1-acylglycerol-3-phosphate O-acyltransferase 5","protein_coding","hsa00561,hsa00564,hsa04072","Glycerolipid metabolism|Glycerophospholipid metabolism|Phospholipase D signaling pathway","GO:0002244,GO:0003841,GO:0005515,GO:0005635,GO:0005730,GO:0005739,GO:0005741,GO:0005783,GO:0005789,GO:0006639,GO:0006654,GO:0008654,GO:0012505,GO:0016024,GO:0016746,GO:0036149","hematopoietic progenitor cell differentiation|1-acylglycerol-3-phosphate O-acyltransferase activity|protein binding|nuclear envelope|nucleolus|mitochondrion|mitochondrial outer membrane|endoplasmic reticulum|endoplasmic reticulum membrane|acylglycerol metabolic process|phosphatidic acid biosynthetic process|phospholipid biosynthetic process|endomembrane system|CDP-diacylglycerol biosynthetic process|acyltransferase activity|phosphatidylinositol acyl-chain remodeling","WP325","Triacylglyceride synthesis","R-HSA-1430728,R-HSA-1483166,R-HSA-1483206,R-HSA-1483257,R-HSA-556833","Metabolism|Synthesis of PA|Glycerophospholipid biosynthesis|Phospholipid metabolism|Metabolism of lipids"]
["AGPS",7.59586900986551,6.65689870674588,5.73650483322343,5.46507105499821,7.81044209920175,6.03617512825975,6.05486099239521,5.58780648925169,7.88602044177709,5.04625549530248,5.87358591727722,6.9406145093353,8.61125226635446,5.44391950911639,6.99298206803894,6.95657703234578,7.70460289014959,6.10271190558695,6.74293379468835,7.62402007173934,7.63307867314469,6.9377229742979,9.3691372711561,8.66832047595182,7.69696843252996,6.13845941005562,8.00229528366114,6.468934560865,8540,"alkylglycerone phosphate synthase","protein_coding","hsa00565,hsa04146","Ether lipid metabolism|Peroxisome","GO:0005515,GO:0005739,GO:0005777,GO:0005778,GO:0005782,GO:0005829,GO:0008609,GO:0008610,GO:0008611,GO:0016020,GO:0071949","protein binding|mitochondrion|peroxisome|peroxisomal membrane|peroxisomal matrix|cytosol|alkylglycerone-phosphate synthase activity|lipid biosynthetic process|ether lipid biosynthetic process|membrane|FAD binding","WP5275,WP325,WP2533","Ether lipid biosynthesis|Triacylglyceride synthesis|Glycerophospholipid biosynthetic pathway","R-HSA-1430728,R-HSA-556833,R-HSA-75896,R-HSA-8848584,R-HSA-9033241,R-HSA-9033241,R-HSA-9033500,R-HSA-9609507,R-HSA-9609507","Metabolism|Metabolism of lipids|Plasmalogen biosynthesis|Wax and plasmalogen biosynthesis|Peroxisomal protein import|Peroxisomal protein import|TYSND1 cleaves peroxisomal proteins|Protein localization|Protein localization"]
["AGRN",12.4050996652896,11.2472012869642,8.62888775873758,10.6788616541213,12.4782630070729,10.9762430903491,7.4951483740483,10.499114930661,8.70446715837215,11.9189498308262,8.82145379368839,8.48945108899189,8.41886794037208,10.0685433863077,7.44022887400637,8.93780036119004,8.67400137936175,10.1675454605412,6.44679579937712,9.31036663024293,8.81586794306544,9.1462979669105,4.12257339193361,6.47450443544159,9.31610375092776,7.96415532364718,4.19825581254909,8.65624270342283,375790,"agrin","protein_coding","hsa04512","ECM-receptor interaction","GO:0002162,GO:0005200,GO:0005201,GO:0005509,GO:0005515,GO:0005576,GO:0005604,GO:0005796,GO:0005886,GO:0007010,GO:0007165,GO:0007213,GO:0007528,GO:0033691,GO:0035374,GO:0043113,GO:0043202,GO:0043236,GO:0043395,GO:0043547,GO:0045162,GO:0045202,GO:0045887,GO:0045944,GO:0050808,GO:0051491,GO:0062023,GO:0070062","dystroglycan binding|structural constituent of cytoskeleton|extracellular matrix structural constituent|calcium ion binding|protein binding|extracellular region|basement membrane|Golgi lumen|plasma membrane|cytoskeleton organization|signal transduction|G protein-coupled acetylcholine receptor signaling pathway|neuromuscular junction development|sialic acid binding|chondroitin sulfate binding|receptor clustering|lysosomal lumen|laminin binding|heparan sulfate proteoglycan binding|positive regulation of GTPase activity|clustering of voltage-gated sodium channels|synapse|positive regulation of synaptic assembly at neuromuscular junction|positive regulation of transcription by RNA polymerase II|synapse organization|positive regulation of filopodium assembly|collagen-containing extracellular matrix|extracellular exosome","WP2572,WP4148,WP5265,WP5345","Primary focal segmental glomerulosclerosis (FSGS)|Splicing factor NOVA regulated synaptic proteins|Neurogenesis regulation in the olfactory epithelium|1p36 copy number variation syndrome","R-HSA-1266738,R-HSA-1430728,R-HSA-1430728,R-HSA-1474244,R-HSA-1474244,R-HSA-1630316,R-HSA-1630316,R-HSA-1638091,R-HSA-1638091,R-HSA-1643685,R-HSA-1643685,R-HSA-1793185,R-HSA-196854,R-HSA-1971475,R-HSA-2022928,R-HSA-2022928,R-HSA-2024096,R-HSA-216083,R-HSA-2187338,R-HSA-3000171,R-HSA-3000178,R-HSA-3000178,R-HSA-3560782,R-HSA-3560783,R-HSA-3560801,R-HSA-3656237,R-HSA-3656253,R-HSA-375165,R-HSA-3781865,R-HSA-419037,R-HSA-422475,R-HSA-4420332,R-HSA-5663205,R-HSA-5663205,R-HSA-5668914,R-HSA-6806667,R-HSA-71387,R-HSA-71387,R-HSA-9675108,R-HSA-9679506,R-HSA-9679506,R-HSA-9694516,R-HSA-9694516,R-HSA-9694614,R-HSA-9694614,R-HSA-9709957,R-HSA-975634,R-HSA-9772572,R-HSA-9772572,R-HSA-9824446,R-HSA-9824446","Developmental Biology|Metabolism|Metabolism|Extracellular matrix organization|Extracellular matrix organization|Glycosaminoglycan metabolism|Glycosaminoglycan metabolism|Heparan sulfate/heparin (HS-GAG) metabolism|Heparan sulfate/heparin (HS-GAG) metabolism|Disease|Disease|Chondroitin sulfate/dermatan sulfate metabolism|Metabolism of vitamins and cofactors|A tetrasaccharide linker sequence is required for GAG synthesis|HS-GAG biosynthesis|HS-GAG biosynthesis|HS-GAG degradation|Integrin cell surface interactions|Visual phototransduction|Non-integrin membrane-ECM interactions|ECM proteoglycans|ECM proteoglycans|Diseases associated with glycosaminoglycan metabolism|Defective B4GALT7 causes EDS, progeroid type|Defective B3GAT3 causes JDSSDHD|Defective EXT2 causes exostoses 2|Defective EXT1 causes exostoses 1, TRPS2 and CHDS|NCAM signaling for neurite out-growth|Diseases of glycosylation|NCAM1 interactions|Axon guidance|Defective B3GALT6 causes EDSP2 and SEMDJL1|Infectious disease|Infectious disease|Diseases of metabolism|Metabolism of fat-soluble vitamins|Metabolism of carbohydrates|Metabolism of carbohydrates|Nervous system development|SARS-CoV Infections|SARS-CoV Infections|SARS-CoV-2 Infection|SARS-CoV-2 Infection|Attachment and Entry|Attachment and Entry|Sensory Perception|Retinoid metabolism and transport|Early SARS-CoV-2 Infection Events|Early SARS-CoV-2 Infection Events|Viral Infection Pathways|Viral Infection Pathways"]
["AGRP",0,0,0,0,0,0,0,0,0.0544463823835706,0,0.407241156883861,0,0,0,0,0,0,0,0.0500271265390022,0,0,0,0,0,0.053664694204839,0,0,0.0508874724045442,181,"agouti related neuropeptide","protein_coding","hsa04920","Adipocytokine signaling pathway","GO:0005102,GO:0005184,GO:0005615,GO:0005796,GO:0007218,GO:0007623,GO:0007631,GO:0008343,GO:0009755,GO:0032868,GO:0042755,GO:0043025,GO:0048571,GO:0060135,GO:0060259,GO:0070996,GO:2000253","signaling receptor binding|neuropeptide hormone activity|extracellular space|Golgi lumen|neuropeptide signaling pathway|circadian rhythm|feeding behavior|adult feeding behavior|hormone-mediated signaling pathway|response to insulin|eating behavior|neuronal cell body|long-day photoperiodism|maternal process involved in female pregnancy|regulation of feeding behavior|type 1 melanocortin receptor binding|positive regulation of feeding behavior","WP4746,WP5400,WP3594","Thyroid hormones production and peripheral downstream signaling effects|6q16 copy number variation|Circadian rhythm genes","R-HSA-212436,R-HSA-73857,R-HSA-74160,R-HSA-9614085,R-HSA-9615017","Generic Transcription Pathway|RNA Polymerase II Transcription|Gene expression (Transcription)|FOXO-mediated transcription|FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes"]
["AGT",1.36940040783157,2.62852293155892,3.01141396830158,2.65033307096574,1.56716807627003,2.72247874462501,2.32507134426602,2.70985467226017,1.97307709377386,2.64969828229348,3.58507343842118,1.99832995283705,2.34646422657304,2.68168184729701,4.4745814449927,2.88923154532965,0.0237224421894174,0.0913194931640282,0.136824763476923,0.0474538549087666,0.0349327277147712,0.0586335837615227,0.0121792763339632,0.0120528532071737,0.0244622587771257,0.0586115629148271,0.143258770132414,0.0463926064209849,183,"angiotensinogen","protein_coding","hsa04072,hsa04080,hsa04924,hsa04614,hsa04925,hsa04927,hsa04261,hsa04270,hsa05200,hsa05410,hsa05414,hsa05415,hsa04931,hsa04933,hsa04934","Phospholipase D signaling pathway|Neuroactive ligand-receptor interaction|Renin secretion|Renin-angiotensin system|Aldosterone synthesis and secretion|Cortisol synthesis and secretion|Adrenergic signaling in cardiomyocytes|Vascular smooth muscle contraction|Pathways in cancer|Hypertrophic cardiomyopathy|Dilated cardiomyopathy|Diabetic cardiomyopathy|Insulin resistance|AGE-RAGE signaling pathway in diabetic complications|Cushing syndrome","GO:0001558,GO:0001819,GO:0001822,GO:0001974,GO:0002016,GO:0002018,GO:0002019,GO:0002034,GO:0003014,GO:0004867,GO:0005179,GO:0005515,GO:0005576,GO:0005615,GO:0005829,GO:0007186,GO:0007199,GO:0007200,GO:0007263,GO:0007267,GO:0008083,GO:0008217,GO:0010536,GO:0010595,GO:0010613,GO:0010718,GO:0010744,GO:0014873,GO:0019229,GO:0031702,GO:0031703,GO:0033864,GO:0034374,GO:0035813,GO:0038166,GO:0042127,GO:0042310,GO:0042981,GO:0043407,GO:0045742,GO:0045893,GO:0048146,GO:0050729,GO:0050731,GO:0051092,GO:0051247,GO:0051387,GO:0051897,GO:0061098,GO:0062023,GO:0070062,GO:0072562,GO:0090190,GO:1901201,GO:1901394,GO:1903598,GO:1903779,GO:1905920,GO:2000379,GO:2001238","regulation of cell growth|positive regulation of cytokine production|kidney development|blood vessel remodeling|regulation of blood volume by renin-angiotensin|renin-angiotensin regulation of aldosterone production|regulation of renal output by angiotensin|maintenance of blood vessel diameter homeostasis by renin-angiotensin|renal system process|serine-type endopeptidase inhibitor activity|hormone activity|protein binding|extracellular region|extracellular space|cytosol|G protein-coupled receptor signaling pathway|G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger|phospholipase C-activating G protein-coupled receptor signaling pathway|nitric oxide mediated signal transduction|cell-cell signaling|growth factor activity|regulation of blood pressure|positive regulation of activation of Janus kinase activity|positive regulation of endothelial cell migration|positive regulation of cardiac muscle hypertrophy|positive regulation of epithelial to mesenchymal transition|positive regulation of macrophage derived foam cell differentiation|response to muscle activity involved in regulation of muscle adaptation|regulation of vasoconstriction|type 1 angiotensin receptor binding|type 2 angiotensin receptor binding|positive regulation of NAD(P)H oxidase activity|low-density lipoprotein particle remodeling|regulation of renal sodium excretion|angiotensin-activated signaling pathway|regulation of cell population proliferation|vasoconstriction|regulation of apoptotic process|negative regulation of MAP kinase activity|positive regulation of epidermal growth factor receptor signaling pathway|positive regulation of DNA-templated transcription|positive regulation of fibroblast proliferation|positive regulation of inflammatory response|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of NF-kappaB transcription factor activity|positive regulation of protein metabolic process|negative regulation of neurotrophin TRK receptor signaling pathway|positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction|positive regulation of protein tyrosine kinase activity|collagen-containing extracellular matrix|extracellular exosome|blood microparticle|positive regulation of branching involved in ureteric bud morphogenesis|regulation of extracellular matrix assembly|positive regulation of transforming growth factor beta1 activation|positive regulation of gap junction assembly|regulation of cardiac conduction|positive regulation of CoA-transferase activity|positive regulation of reactive oxygen species metabolic process|positive regulation of extrinsic apoptotic signaling pathway","WP4969,WP5115,WP4883,WP5413,WP364,WP554,WP1528,WP5133,WP5036,WP1544,WP236,WP5183,WP727,WP4756,WP4891","RAS and bradykinin pathways in COVID-19|Network map of SARS-CoV-2 signaling pathway|SARS-CoV-2 and ACE2 receptor: molecular mechanisms|IL-24 Signaling pathway|IL6 signaling pathway|ACE inhibitor pathway|Physiological and pathological hypertrophy of the heart|Non-classical role of vitamin D|Angiotensin II receptor type 1 pathway|MicroRNAs in cardiomyocyte hypertrophy|Adipogenesis|SARS-CoV-2 mitochondrial chronic oxidative stress and endothelial dysfunction|Monoamine transport|Renin-angiotensin-aldosterone system (RAAS)|COVID-19 adverse outcome pathway","R-HSA-1430728,R-HSA-162582,R-HSA-1989781,R-HSA-2022377,R-HSA-2022377,R-HSA-2980736,R-HSA-2980736,R-HSA-372790,R-HSA-373076,R-HSA-375276,R-HSA-388396,R-HSA-392499,R-HSA-392499,R-HSA-400206,R-HSA-416476,R-HSA-418594,R-HSA-500792,R-HSA-556833","Metabolism|Signal Transduction|PPARA activates gene expression|Metabolism of Angiotensinogen to Angiotensins|Metabolism of Angiotensinogen to Angiotensins|Peptide hormone metabolism|Peptide hormone metabolism|Signaling by GPCR|Class A/1 (Rhodopsin-like receptors)|Peptide ligand-binding receptors|GPCR downstream signalling|Metabolism of proteins|Metabolism of proteins|Regulation of lipid metabolism by PPARalpha|G alpha (q) signalling events|G alpha (i) signalling events|GPCR ligand binding|Metabolism of lipids"]
["AGTPBP1",1.46414624923949,1.22014302386298,0.969690160619871,0.882398505330557,1.26429111502503,1.20252522432468,1.11428855484354,1.07571854180659,0.972181523843694,0.617744026902615,0.665592701438014,0.863360237957404,1.08951370428379,0.746439585408197,1.04694673886258,1.042223302702,1.20993116543428,1.01297260439452,1.10790301008379,1.14848218343562,1.45917511841389,1.05325409648806,1.35154692573271,1.31158836104434,1.14241337618962,0.996117650069861,1.29055429440032,0.935664798642794,23287,"ATP/GTP binding carboxypeptidase 1","protein_coding",null,null,"GO:0001754,GO:0004181,GO:0005634,GO:0005730,GO:0005737,GO:0005739,GO:0005829,GO:0006508,GO:0007005,GO:0007628,GO:0008270,GO:0008285,GO:0015631,GO:0021702,GO:0021772,GO:0021954,GO:0035608,GO:0035609,GO:0035610,GO:0042133,GO:0043231,GO:0050905,GO:0060041,GO:0098957,GO:0098958,GO:1904115,GO:2000060","eye photoreceptor cell differentiation|metallocarboxypeptidase activity|nucleus|nucleolus|cytoplasm|mitochondrion|cytosol|proteolysis|mitochondrion organization|adult walking behavior|zinc ion binding|negative regulation of cell population proliferation|tubulin binding|cerebellar Purkinje cell differentiation|olfactory bulb development|central nervous system neuron development|protein deglutamylation|C-terminal protein deglutamylation|protein side chain deglutamylation|neurotransmitter metabolic process|intracellular membrane-bounded organelle|neuromuscular process|retina development in camera-type eye|anterograde axonal transport of mitochondrion|retrograde axonal transport of mitochondrion|axon cytoplasm|positive regulation of ubiquitin-dependent protein catabolic process",null,null,"R-HSA-392499,R-HSA-597592,R-HSA-8955332","Metabolism of proteins|Post-translational protein modification|Carboxyterminal post-translational modifications of tubulin"]
["AGTR1",0.505231679535989,0.39045431055948,0.43480211893268,0.403788821335146,0.534832057266697,0.751193965675692,0.382993482978936,0.402535745482809,0.0211747742499166,0.0506877984077412,0.0395950988145573,0.0211793769754583,0.0400392372906061,0.0301047845020652,0.0195776098225033,0.0199598490801615,0.0101197844950951,0.00973902247966622,0.0486401972206621,0.020243395739097,0.029803986746105,0.0100050277640708,0,0,0.0417415348910736,0.0500063510226073,0.0203709757086636,0.00989533824969271,185,"angiotensin II receptor type 1","protein_coding","hsa04371,hsa04020,hsa04072,hsa04022,hsa04080,hsa04924,hsa04614,hsa04925,hsa04927,hsa04261,hsa04270,hsa05200,hsa05171,hsa05415,hsa04933,hsa04934","Apelin signaling pathway|Calcium signaling pathway|Phospholipase D signaling pathway|cGMP-PKG signaling pathway|Neuroactive ligand-receptor interaction|Renin secretion|Renin-angiotensin system|Aldosterone synthesis and secretion|Cortisol synthesis and secretion|Adrenergic signaling in cardiomyocytes|Vascular smooth muscle contraction|Pathways in cancer|Coronavirus disease - COVID-19|Diabetic cardiomyopathy|AGE-RAGE signaling pathway in diabetic complications|Cushing syndrome","GO:0001558,GO:0001596,GO:0001822,GO:0002018,GO:0002034,GO:0003081,GO:0004945,GO:0005515,GO:0005886,GO:0006954,GO:0007186,GO:0007200,GO:0007204,GO:0007266,GO:0010744,GO:0016020,GO:0019229,GO:0019722,GO:0031711,GO:0032430,GO:0033864,GO:0034374,GO:0035813,GO:0038166,GO:0042127,GO:0046718,GO:0046982,GO:0050727,GO:0050729,GO:0051247,GO:0060326,GO:0086097,GO:0097746,GO:1903589,GO:1905920,GO:2000379","regulation of cell growth|angiotensin type I receptor activity|kidney development|renin-angiotensin regulation of aldosterone production|maintenance of blood vessel diameter homeostasis by renin-angiotensin|regulation of systemic arterial blood pressure by renin-angiotensin|angiotensin type II receptor activity|protein binding|plasma membrane|inflammatory response|G protein-coupled receptor signaling pathway|phospholipase C-activating G protein-coupled receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|Rho protein signal transduction|positive regulation of macrophage derived foam cell differentiation|membrane|regulation of vasoconstriction|calcium-mediated signaling|bradykinin receptor binding|positive regulation of phospholipase A2 activity|positive regulation of NAD(P)H oxidase activity|low-density lipoprotein particle remodeling|regulation of renal sodium excretion|angiotensin-activated signaling pathway|regulation of cell population proliferation|viral entry into host cell|protein heterodimerization activity|regulation of inflammatory response|positive regulation of inflammatory response|positive regulation of protein metabolic process|cell chemotaxis|phospholipase C-activating angiotensin-activated signaling pathway|blood vessel diameter maintenance|positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis|positive regulation of CoA-transferase activity|positive regulation of reactive oxygen species metabolic process","WP4969,WP4883,WP3668,WP4799,WP554,WP24,WP5133,WP5036,WP455,WP4538,WP5076,WP5158,WP5038,WP2328,WP5356,WP4756","RAS and bradykinin pathways in COVID-19|SARS-CoV-2 and ACE2 receptor: molecular mechanisms|Hypothesized pathways in pathogenesis of cardiovascular disease|Downregulation of ACE2 by SARS-CoV-2 spike protein|ACE inhibitor pathway|Peptide GPCRs|Non-classical role of vitamin D|Angiotensin II receptor type 1 pathway|GPCRs, class A rhodopsin-like|Regulatory circuits of the STAT3 signaling pathway|Soluble ACE2-mediated cell entry of SARS-CoV-2|Urotensin-II-mediated signaling pathway|Mitochondrial immune response to SARS-CoV-2|Allograft rejection|Disturbed pathways in Duchenne Muscular Dystrophy|Renin-angiotensin-aldosterone system (RAAS)","R-HSA-162582,R-HSA-199991,R-HSA-372790,R-HSA-373076,R-HSA-375276,R-HSA-388396,R-HSA-416476,R-HSA-500792,R-HSA-5653656,R-HSA-8856825,R-HSA-8856828","Signal Transduction|Membrane Trafficking|Signaling by GPCR|Class A/1 (Rhodopsin-like receptors)|Peptide ligand-binding receptors|GPCR downstream signalling|G alpha (q) signalling events|GPCR ligand binding|Vesicle-mediated transport|Cargo recognition for clathrin-mediated endocytosis|Clathrin-mediated endocytosis"]
["AGTRAP",27.9249542202596,26.3409222453089,30.705066333256,29.1649410069993,24.6736203950323,26.8360106029145,28.0775115556899,29.4482152845108,16.3109451475031,23.6094577819797,24.1228344808693,18.6663197994082,16.9231857934667,20.3587838680536,19.4873310397085,17.4117872214938,30.2092328071659,34.5090924736117,35.3071135592121,27.1975003527939,27.8676745051038,31.828416410171,26.5285571684918,26.1503128839878,27.5601745175726,34.25772587918,28.5508853025908,35.2213664664271,57085,"angiotensin II receptor associated protein","protein_coding",null,null,"GO:0000139,GO:0001666,GO:0004945,GO:0005515,GO:0005789,GO:0005794,GO:0005886,GO:0005938,GO:0008217,GO:0030659,GO:0038166,GO:0043231","Golgi membrane|response to hypoxia|angiotensin type II receptor activity|protein binding|endoplasmic reticulum membrane|Golgi apparatus|plasma membrane|cell cortex|regulation of blood pressure|cytoplasmic vesicle membrane|angiotensin-activated signaling pathway|intracellular membrane-bounded organelle","WP5413","IL-24 Signaling pathway","R-HSA-1643685,R-HSA-5663202,R-HSA-6802952,R-HSA-6802957","Disease|Diseases of signal transduction by growth factor receptors and second messengers|Signaling by BRAF and RAF1 fusions|Oncogenic MAPK signaling"]
["AGXT",0,0,0,0.00891468251240785,0.00908292373116719,0,0,0,0,0,0,0,0,0,0.00864452737162604,0,0,0,0,0,0,0,0,0,0,0,0,0,189,"alanine--glyoxylate and serine--pyruvate aminotransferase","protein_coding","hsa00630,hsa00250,hsa00260,hsa04146","Glyoxylate and dicarboxylate metabolism|Alanine, aspartate and glutamate metabolism|Glycine, serine and threonine metabolism|Peroxisome","GO:0004760,GO:0005515,GO:0005777,GO:0005782,GO:0005829,GO:0006563,GO:0007219,GO:0008453,GO:0008483,GO:0009436,GO:0016597,GO:0019265,GO:0019448,GO:0030170,GO:0042802,GO:0042803,GO:0042853,GO:0043231,GO:0043621,GO:0046487,GO:0046724","serine-pyruvate transaminase activity|protein binding|peroxisome|peroxisomal matrix|cytosol|L-serine metabolic process|Notch signaling pathway|alanine-glyoxylate transaminase activity|transaminase activity|glyoxylate catabolic process|amino acid binding|glycine biosynthetic process, by transamination of glyoxylate|L-cysteine catabolic process|pyridoxal phosphate binding|identical protein binding|protein homodimerization activity|L-alanine catabolic process|intracellular membrane-bounded organelle|protein self-association|glyoxylate metabolic process|oxalic acid secretion","WP106,WP5224,WP5166","Alanine and aspartate metabolism|2q37 copy number variation syndrome|Glyoxylate metabolism","R-HSA-1430728,R-HSA-389661,R-HSA-71291,R-HSA-9033241,R-HSA-9033241,R-HSA-9609507,R-HSA-9609507","Metabolism|Glyoxylate metabolism and glycine degradation|Metabolism of amino acids and derivatives|Peroxisomal protein import|Peroxisomal protein import|Protein localization|Protein localization"]
["AHCTF1",6.4396881410946,6.36144591223912,4.23595299931981,4.74687043158222,6.5815082541227,5.08097679776165,4.11303158111052,4.01846970926537,5.83208722336105,4.29999543930153,3.753814711158,4.82791180962067,5.36209027474139,3.83081649212838,4.88348950036445,4.90034108083939,4.76149901875585,4.34160110093943,4.09349967166851,5.53291284442867,4.91997666374518,4.40959664438295,4.94755548410199,5.15906272723558,5.25002815902069,3.9921501046573,4.46624313814931,3.94152693463667,25909,"AT-hook containing transcription factor 1","protein_coding","hsa03013","Nucleocytoplasmic transport","GO:0000776,GO:0000785,GO:0003677,GO:0005634,GO:0005635,GO:0005643,GO:0005654,GO:0005829,GO:0006913,GO:0007049,GO:0015031,GO:0016363,GO:0016604,GO:0031965,GO:0032465,GO:0051028,GO:0051292,GO:0051301,GO:0070062","kinetochore|chromatin|DNA binding|nucleus|nuclear envelope|nuclear pore|nucleoplasm|cytosol|nucleocytoplasmic transport|cell cycle|protein transport|nuclear matrix|nuclear body|nuclear membrane|regulation of cytokinesis|mRNA transport|nuclear pore complex assembly|cell division|extracellular exosome","WP2363,WP3998","Gastric cancer network 2|Prader-Willi and Angelman syndrome","R-HSA-141424,R-HSA-141444,R-HSA-162582,R-HSA-1640170,R-HSA-1640170,R-HSA-194315,R-HSA-195258,R-HSA-2467813,R-HSA-2500257,R-HSA-2555396,R-HSA-2555396,R-HSA-2995410,R-HSA-2995410,R-HSA-5663220,R-HSA-68877,R-HSA-68882,R-HSA-68882,R-HSA-68886,R-HSA-68886,R-HSA-69278,R-HSA-69278,R-HSA-69618,R-HSA-69620,R-HSA-9615933,R-HSA-9615933,R-HSA-9648025,R-HSA-9716542","Amplification of signal from the kinetochores|Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal|Signal Transduction|Cell Cycle|Cell Cycle|Signaling by Rho GTPases|RHO GTPase Effectors|Separation of Sister Chromatids|Resolution of Sister Chromatid Cohesion|Mitotic Metaphase and Anaphase|Mitotic Metaphase and Anaphase|Nuclear Envelope (NE) Reassembly|Nuclear Envelope (NE) Reassembly|RHO GTPases Activate Formins|Mitotic Prometaphase|Mitotic Anaphase|Mitotic Anaphase|M Phase|M Phase|Cell Cycle, Mitotic|Cell Cycle, Mitotic|Mitotic Spindle Checkpoint|Cell Cycle Checkpoints|Postmitotic nuclear pore complex (NPC) reformation|Postmitotic nuclear pore complex (NPC) reformation|EML4 and NUDC in mitotic spindle formation|Signaling by Rho GTPases, Miro GTPases and RHOBTB3"]
["AHCY",23.4911776802843,23.9891033113137,24.7569348632843,25.1424996527707,23.9964019312932,25.5802421223009,27.0288260216981,25.1147161065795,24.9039260437126,28.8260718766163,24.6154729397481,26.0356228952752,25.7872087518285,27.6702505118264,26.4352344284018,25.4518820342935,25.3586834351576,25.7746685982662,28.745514358435,24.0819189925878,24.9618812644474,25.9494256124691,27.442055873458,25.9361987349807,23.4482521933731,28.25280818035,29.4724778859154,27.2909145512692,191,"adenosylhomocysteinase","protein_coding","hsa00270","Cysteine and methionine metabolism","GO:0004013,GO:0005515,GO:0005634,GO:0005783,GO:0005829,GO:0006730,GO:0033353,GO:0042470,GO:0070062","adenosylhomocysteinase activity|protein binding|nucleus|endoplasmic reticulum|cytosol|one-carbon metabolic process|S-adenosylmethionine cycle|melanosome|extracellular exosome","WP3996,WP2525,WP4292,WP3591,WP4504,WP2333,WP3594,WP176,WP241,WP3580","Ethanol effects on histone modifications|Trans-sulfuration, one-carbon metabolism and related pathways|Methionine metabolism leading to sulfur amino acids and related disorders|Sleep regulation|Cysteine and methionine catabolism|Trans-sulfuration pathway|Circadian rhythm genes|Folate metabolism|One-carbon metabolism|Methionine de novo and salvage pathway","R-HSA-1430728,R-HSA-1430728,R-HSA-156580,R-HSA-156581,R-HSA-1614635,R-HSA-1643685,R-HSA-211859,R-HSA-2408508,R-HSA-2408522,R-HSA-5578997,R-HSA-5579029,R-HSA-5668914,R-HSA-71291,R-HSA-71291","Metabolism|Metabolism|Phase II - Conjugation of compounds|Methylation|Sulfur amino acid metabolism|Disease|Biological oxidations|Metabolism of ingested SeMet, Sec, MeSec into H2Se|Selenoamino acid metabolism|Defective AHCY causes HMAHCHD|Metabolic disorders of biological oxidation enzymes|Diseases of metabolism|Metabolism of amino acids and derivatives|Metabolism of amino acids and derivatives"]
["AHCYL1",30.8737650339237,29.546707783598,30.671540826187,28.329597752192,31.9076090058526,30.44928354804,31.0627655848815,28.7317180652585,30.3835143605495,25.7009951517674,28.4379623017877,31.307226724018,30.9860921216264,29.1757052830924,33.9452563051313,31.315442336933,30.0797272178176,30.1629131471647,28.2333043000125,31.6924744189879,28.8534627388533,31.0434966321829,29.7989113581229,31.6524107291817,31.7117510918051,28.1137416616504,30.3275279116737,27.6731360349712,10768,"adenosylhomocysteinase like 1","protein_coding","hsa00270","Cysteine and methionine metabolism","GO:0003723,GO:0004013,GO:0005515,GO:0005737,GO:0005789,GO:0005829,GO:0006378,GO:0006611,GO:0006730,GO:0006915,GO:0010765,GO:0016324,GO:0030234,GO:0031440,GO:0032412,GO:0033353,GO:0038166,GO:0042045,GO:0042802,GO:0044070,GO:0044233,GO:0051592,GO:0070062,GO:1990456","RNA binding|adenosylhomocysteinase activity|protein binding|cytoplasm|endoplasmic reticulum membrane|cytosol|mRNA polyadenylation|protein export from nucleus|one-carbon metabolic process|apoptotic process|positive regulation of sodium ion transport|apical plasma membrane|enzyme regulator activity|regulation of mRNA 3'-end processing|regulation of monoatomic ion transmembrane transporter activity|S-adenosylmethionine cycle|angiotensin-activated signaling pathway|epithelial fluid transport|identical protein binding|regulation of monoatomic anion transport|mitochondria-associated endoplasmic reticulum membrane|response to calcium ion|extracellular exosome|mitochondrion-endoplasmic reticulum membrane tethering","WP2525","Trans-sulfuration, one-carbon metabolism and related pathways","R-HSA-111885,R-HSA-112040,R-HSA-112043,R-HSA-1280218,R-HSA-1430728,R-HSA-1489509,R-HSA-162582,R-HSA-163685,R-HSA-1643685,R-HSA-168249,R-HSA-168256,R-HSA-194138,R-HSA-2029480,R-HSA-2029485,R-HSA-2454202,R-HSA-2871809,R-HSA-372790,R-HSA-388396,R-HSA-397014,R-HSA-397014,R-HSA-418594,R-HSA-422356,R-HSA-4420097,R-HSA-5218921,R-HSA-5576891,R-HSA-5576891,R-HSA-5578775,R-HSA-5578775,R-HSA-5607763,R-HSA-5607764,R-HSA-5621481,R-HSA-5663205,R-HSA-9006925,R-HSA-9006934,R-HSA-9658195,R-HSA-9662851,R-HSA-9664323,R-HSA-9664433,R-HSA-9824443,R-HSA-983695,R-HSA-983705","Opioid Signalling|G-protein mediated events|PLC beta mediated events|Adaptive Immune System|Metabolism|DAG and IP3 signaling|Signal Transduction|Integration of energy metabolism|Disease|Innate Immune System|Immune System|Signaling by VEGF|Fcgamma receptor (FCGR) dependent phagocytosis|Role of phospholipids in phagocytosis|Fc epsilon receptor (FCERI) signaling|FCERI mediated Ca+2 mobilization|Signaling by GPCR|GPCR downstream signalling|Muscle contraction|Muscle contraction|G alpha (i) signalling events|Regulation of insulin secretion|VEGFA-VEGFR2 Pathway|VEGFR2 mediated cell proliferation|Cardiac conduction|Cardiac conduction|Ion homeostasis|Ion homeostasis|CLEC7A (Dectin-1) induces NFAT activation|CLEC7A (Dectin-1) signaling|C-type lectin receptors (CLRs)|Infectious disease|Intracellular signaling by second messengers|Signaling by Receptor Tyrosine Kinases|Leishmania infection|Anti-inflammatory response favouring Leishmania parasite infection|FCGR3A-mediated IL10 synthesis|Leishmania parasite growth and survival|Parasitic Infection Pathways|Antigen activates B Cell Receptor (BCR) leading to generation of second messengers|Signaling by the B Cell Receptor (BCR)"]
["AHCYL2",1.61168461547174,1.43278473137568,1.26257093438093,1.1786378468274,1.71211396787443,1.59258883569531,1.29729875359961,1.25675536359434,1.97785686063959,1.30538544652283,1.20859435949764,1.54730287756657,1.90668939385206,1.47963493007367,1.71764518075789,1.7811441851926,1.18156426106272,1.12086291738917,0.814548751220816,1.13113961986597,1.19640535063591,1.00795995614735,1.19591545948284,1.07029713278552,1.22885648730565,0.800726940016552,0.927603802243019,0.854965216319256,23382,"adenosylhomocysteinase like 2","protein_coding","hsa00270","Cysteine and methionine metabolism","GO:0004013,GO:0005515,GO:0005783,GO:0005829,GO:0006730,GO:0033353,GO:0043005","adenosylhomocysteinase activity|protein binding|endoplasmic reticulum|cytosol|one-carbon metabolic process|S-adenosylmethionine cycle|neuron projection","WP2525,WP241","Trans-sulfuration, one-carbon metabolism and related pathways|One-carbon metabolism","R-HSA-382551,R-HSA-425381,R-HSA-425393,R-HSA-425407","Transport of small molecules|Bicarbonate transporters|Transport of inorganic cations/anions and amino acids/oligopeptides|SLC-mediated transmembrane transport"]
["AHDC1",2.56907547889554,3.84083368557349,2.64477580678258,3.12865609193422,3.54810412985132,3.46945127475899,2.64314292234189,2.74683087122591,2.51378138283042,3.8156421053525,2.75096733365637,2.75424457406239,2.39176471398568,2.55842612348281,2.14971184920962,2.69212290224135,1.8983619939955,2.32412041644679,1.72790083765708,2.02102178688688,2.04069540137638,2.18510726858184,1.22417673130299,1.84516131741669,2.41464538439862,2.17824432749646,1.31378977195576,1.96087834216746,27245,"AT-hook DNA binding motif containing 1","protein_coding",null,null,"GO:0001707,GO:0003700,GO:0005515,GO:0005634,GO:0005694,GO:0006355,GO:0030154,GO:0043589,GO:0140585","mesoderm formation|DNA-binding transcription factor activity|protein binding|nucleus|chromosome|regulation of DNA-templated transcription|cell differentiation|skin morphogenesis|promoter-enhancer loop anchoring activity","WP2853,WP2857","Endoderm differentiation|Mesodermal commitment pathway"]
["AHI1",2.63256813252869,2.59549519281294,2.05014838022028,1.84832105110568,2.70819248344911,2.25467650544318,2.16035925710113,2.24264595719099,3.00991286886418,1.98997335797253,2.09720853998001,2.34394155014756,3.19803817384606,2.19737608308151,2.43833477230059,3.02974128613595,2.5276298205168,2.19520681325534,2.28821048849135,2.51783086550503,2.66295687260322,2.02829427595711,3.29525313941561,2.77032449704096,2.60645739037125,1.99029903004391,2.81292296369421,1.93907698798349,54806,"Abelson helper integration site 1","protein_coding",null,null,"GO:0001738,GO:0001947,GO:0002092,GO:0005515,GO:0005813,GO:0005814,GO:0005829,GO:0005911,GO:0005912,GO:0005929,GO:0007169,GO:0007417,GO:0008104,GO:0010842,GO:0016192,GO:0030862,GO:0030902,GO:0035844,GO:0035845,GO:0036038,GO:0036064,GO:0039008,GO:0042802,GO:0043066,GO:0044458,GO:0045944,GO:0050795,GO:0060271,GO:0065001,GO:0071599,GO:0097730","morphogenesis of a polarized epithelium|heart looping|positive regulation of receptor internalization|protein binding|centrosome|centriole|cytosol|cell-cell junction|adherens junction|cilium|transmembrane receptor protein tyrosine kinase signaling pathway|central nervous system development|protein localization|retina layer formation|vesicle-mediated transport|positive regulation of polarized epithelial cell differentiation|hindbrain development|cloaca development|photoreceptor cell outer segment organization|MKS complex|ciliary basal body|pronephric nephron tubule morphogenesis|identical protein binding|negative regulation of apoptotic process|motile cilium assembly|positive regulation of transcription by RNA polymerase II|regulation of behavior|cilium assembly|specification of axis polarity|otic vesicle development|non-motile cilium","WP4656,WP2858,WP4803","Joubert syndrome|Ectoderm differentiation|Ciliopathies","R-HSA-1852241,R-HSA-5617833,R-HSA-5620912","Organelle biogenesis and maintenance|Cilium Assembly|Anchoring of the basal body to the plasma membrane"]
["AHI1-DT",0.06861997938543,0.0870253137380485,0.0536857439438902,0.087747405298202,0.0558771294450251,0.0214792191913834,0.0960327316251808,0.0336442689266497,0.0115037328922436,0.0220299451374162,0.0967996852542143,0.0805436340770133,0.0435046613072729,0.109034582251151,0.0638161969733954,0.0759058579677676,0.010995658927424,0.0952374752370924,0.116270088748686,0.098979641151983,0.097150627989107,0.0978387292889559,0.0564525218279797,0.067039841131119,0.0793700144242974,0.0978019842783263,0.0664022937503872,0.0860142936188818,100131814,"AHI1 divergent transcript","non_coding"]
["AHNAK",135.610990079337,141.387329651925,134.875669884769,112.453586975132,145.973606029466,131.545143546173,123.359176974872,119.481629691419,128.325538112667,123.233516986406,107.98161721805,129.20517752554,123.571042918602,122.877861010676,123.767110094694,132.089823674144,118.529351836701,125.819501195524,86.5349684277833,135.430055685158,111.82519920081,114.20950066538,101.525539303034,116.137706427029,126.246111475479,97.131172136433,92.5627936507497,99.8413940603964,79026,"AHNAK nucleoprotein","protein_coding","hsa05132","Salmonella infection","GO:0003723,GO:0005515,GO:0005634,GO:0005737,GO:0005765,GO:0005829,GO:0005886,GO:0005925,GO:0015629,GO:0016020,GO:0030315,GO:0031982,GO:0042383,GO:0043034,GO:0043484,GO:0044291,GO:0044548,GO:0045121,GO:0045296,GO:0070062,GO:0097493,GO:0098797,GO:1901385,GO:1905686","RNA binding|protein binding|nucleus|cytoplasm|lysosomal membrane|cytosol|plasma membrane|focal adhesion|actin cytoskeleton|membrane|T-tubule|vesicle|sarcolemma|costamere|regulation of RNA splicing|cell-cell contact zone|S100 protein binding|membrane raft|cadherin binding|extracellular exosome|structural molecule activity conferring elasticity|plasma membrane protein complex|regulation of voltage-gated calcium channel activity|positive regulation of plasma membrane repair"]
["AHNAK2",3.45562757036873,3.84687150489764,3.36271049798376,2.87606293848041,4.0781052259437,3.54731517690049,3.14424552737784,2.98900132676956,2.57446536788892,2.74860333519113,2.38929125031296,2.41745970755243,2.48918148496076,2.56040579481287,2.47063559201543,2.7416118120292,2.11360591895093,2.50100653974245,1.59487200653846,2.48911602643424,2.23918490241332,2.13374642039162,1.67352193583143,1.98058028900043,2.2485301901507,2.0158259793372,1.50428516172896,1.80770566611415,113146,"AHNAK nucleoprotein 2","protein_coding","hsa05132","Salmonella infection","GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0030315,GO:0042383,GO:0043034,GO:0043484","protein binding|nucleus|cytoplasm|cytosol|plasma membrane|T-tubule|sarcolemma|costamere|regulation of RNA splicing"]
["AHR",17.3922208821975,13.9431736727448,10.1748716698424,8.33593498361098,17.9189513935887,11.4179304252442,10.4015786796501,8.79412400253381,8.67327470106604,5.47690795829475,4.04036652345671,6.99399478928234,9.3744966818411,5.49144124344378,8.09938073920426,8.20429406395681,7.77544556082027,6.22042738109114,7.15919192302788,8.11323718542487,8.11002936691667,7.01007086100681,10.5671073009274,9.86684249218338,9.00679757652999,5.51815237492125,8.50281034658187,5.94275689266793,196,"aryl hydrocarbon receptor","protein_coding","hsa04659,hsa05207,hsa05208,hsa04934","Th17 cell differentiation|Chemical carcinogenesis - receptor activation|Chemical carcinogenesis - reactive oxygen species|Cushing syndrome","GO:0000785,GO:0000976,GO:0000981,GO:0000987,GO:0001094,GO:0001223,GO:0001568,GO:0002819,GO:0002841,GO:0003677,GO:0003700,GO:0004879,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0005737,GO:0005829,GO:0006355,GO:0006357,GO:0006805,GO:0006915,GO:0007049,GO:0009410,GO:0009636,GO:0010468,GO:0017025,GO:0019933,GO:0030522,GO:0030888,GO:0032922,GO:0032991,GO:0034751,GO:0034752,GO:0034753,GO:0042803,GO:0045892,GO:0045893,GO:0045944,GO:0046982,GO:0050728,GO:0051879,GO:0061629,GO:0070888,GO:0071219,GO:0071320,GO:1904322,GO:1904613,GO:1990837","chromatin|transcription cis-regulatory region binding|DNA-binding transcription factor activity, RNA polymerase II-specific|cis-regulatory region sequence-specific DNA binding|TFIID-class transcription factor complex binding|transcription coactivator binding|blood vessel development|regulation of adaptive immune response|negative regulation of T cell mediated immune response to tumor cell|DNA binding|DNA-binding transcription factor activity|nuclear receptor activity|protein binding|nucleus|nucleoplasm|transcription regulator complex|cytoplasm|cytosol|regulation of DNA-templated transcription|regulation of transcription by RNA polymerase II|xenobiotic metabolic process|apoptotic process|cell cycle|response to xenobiotic stimulus|response to toxic substance|regulation of gene expression|TBP-class protein binding|cAMP-mediated signaling|intracellular receptor signaling pathway|regulation of B cell proliferation|circadian regulation of gene expression|protein-containing complex|aryl hydrocarbon receptor complex|cytosolic aryl hydrocarbon receptor complex|nuclear aryl hydrocarbon receptor complex|protein homodimerization activity|negative regulation of DNA-templated transcription|positive regulation of DNA-templated transcription|positive regulation of transcription by RNA polymerase II|protein heterodimerization activity|negative regulation of inflammatory response|Hsp90 protein binding|RNA polymerase II-specific DNA-binding transcription factor binding|E-box binding|cellular response to molecule of bacterial origin|cellular response to cAMP|cellular response to forskolin|cellular response to 2,3,7,8-tetrachlorodibenzodioxine|sequence-specific double-stranded DNA binding","WP5115,WP3893,WP236,WP3869,WP2586,WP465,WP2882,WP5088,WP3594,WP5130,WP5044,WP2873,WP4673","Network map of SARS-CoV-2 signaling pathway|Development and heterogeneity of the ILC family|Adipogenesis|Cannabinoid receptor signaling|Aryl hydrocarbon receptor pathway|Tryptophan metabolism|Nuclear receptors meta-pathway|Prostaglandin signaling|Circadian rhythm genes|Th17 cell differentiation pathway|Kynurenine pathway and links to cell senescence|Aryl hydrocarbon receptor pathway|Male infertility","R-HSA-1430728,R-HSA-1989781,R-HSA-211859,R-HSA-211897,R-HSA-211945,R-HSA-211976,R-HSA-211981,R-HSA-400206,R-HSA-556833,R-HSA-8937144","Metabolism|PPARA activates gene expression|Biological oxidations|Cytochrome P450 - arranged by substrate type|Phase I - Functionalization of compounds|Endogenous sterols|Xenobiotics|Regulation of lipid metabolism by PPARalpha|Metabolism of lipids|Aryl hydrocarbon receptor signalling","bHLH"]
["AHRR",0,0.0224359757263497,0.0265741613879767,0,0,0,0.00440145351457533,0,0,0,0,0,0,0.004497628812845,0,4.47297632956718E-3,4.53566119914921E-3,0.00436500465005691,0,0.00453651876862334,0,0.0179369101181557,0,0,0,0,0.00913021854915779,0.00887012994660939,57491,"aryl-hydrocarbon receptor repressor","protein_coding",null,null,"GO:0000785,GO:0000976,GO:0000981,GO:0004879,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006357,GO:0030522,GO:0034751,GO:0046983","chromatin|transcription cis-regulatory region binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nuclear receptor activity|protein binding|nucleus|nucleoplasm|cytoplasm|regulation of transcription by RNA polymerase II|intracellular receptor signaling pathway|aryl hydrocarbon receptor complex|protein dimerization activity","WP2586,WP2882,WP2873,WP4673","Aryl hydrocarbon receptor pathway|Nuclear receptors meta-pathway|Aryl hydrocarbon receptor pathway|Male infertility","R-HSA-1430728,R-HSA-1989781,R-HSA-211859,R-HSA-211897,R-HSA-211945,R-HSA-211976,R-HSA-211981,R-HSA-400206,R-HSA-556833,R-HSA-8937144","Metabolism|PPARA activates gene expression|Biological oxidations|Cytochrome P450 - arranged by substrate type|Phase I - Functionalization of compounds|Endogenous sterols|Xenobiotics|Regulation of lipid metabolism by PPARalpha|Metabolism of lipids|Aryl hydrocarbon receptor signalling","bHLH"]
["AHSA1",60.0160745258165,55.7970764872328,58.4875771894792,62.7365413368033,51.3032037589051,52.7693489234896,51.3210388564834,55.995409462131,57.5502383681515,64.5036945240514,70.3470560554673,65.0100684735512,51.5348867264846,59.4642494047053,56.8153083556897,52.7706539858504,57.7731671368128,60.9379283035165,70.1110381060937,57.7662503604905,53.8270940386617,61.3150311169043,57.25274118144,56.2415744332858,59.3541859346936,62.649346964826,58.1482631832229,65.2647068309888,10598,"activator of HSP90 ATPase activity 1","protein_coding",null,null,"GO:0001671,GO:0005515,GO:0005783,GO:0005829,GO:0006457,GO:0032781,GO:0045296,GO:0051087,GO:0051879,GO:0070062","ATPase activator activity|protein binding|endoplasmic reticulum|cytosol|protein folding|positive regulation of ATP-dependent activity|cadherin binding|protein-folding chaperone binding|Hsp90 protein binding|extracellular exosome","WP3863","T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection"]
["AHSG",0,0.0162586132276934,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,197,"alpha 2-HS glycoprotein","protein_coding",null,null,"GO:0001501,GO:0001503,GO:0004866,GO:0004869,GO:0005576,GO:0005615,GO:0005788,GO:0005794,GO:0006907,GO:0006953,GO:0010951,GO:0019210,GO:0030500,GO:0030502,GO:0031012,GO:0031093,GO:0034774,GO:0046627,GO:0050727,GO:0050766,GO:0062023,GO:0070062,GO:0072562","skeletal system development|ossification|endopeptidase inhibitor activity|cysteine-type endopeptidase inhibitor activity|extracellular region|extracellular space|endoplasmic reticulum lumen|Golgi apparatus|pinocytosis|acute-phase response|negative regulation of endopeptidase activity|kinase inhibitor activity|regulation of bone mineralization|negative regulation of bone mineralization|extracellular matrix|platelet alpha granule lumen|secretory granule lumen|negative regulation of insulin receptor signaling pathway|regulation of inflammatory response|positive regulation of phagocytosis|collagen-containing extracellular matrix|extracellular exosome|blood microparticle",null,null,"R-HSA-109582,R-HSA-114608,R-HSA-168249,R-HSA-168256,R-HSA-381426,R-HSA-392499,R-HSA-597592,R-HSA-6798695,R-HSA-76002,R-HSA-76005,R-HSA-8957275","Hemostasis|Platelet degranulation |Innate Immune System|Immune System|Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)|Metabolism of proteins|Post-translational protein modification|Neutrophil degranulation|Platelet activation, signaling and aggregation|Response to elevated platelet cytosolic Ca2+|Post-translational protein phosphorylation"]
["AHSP",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.0474175600198197,0,0,0,0,0,0,0,0,0,0,51327,"alpha hemoglobin stabilizing protein","protein_coding",null,null,"GO:0005515,GO:0005737,GO:0005833,GO:0006457,GO:0020027,GO:0030097,GO:0030218,GO:0030492,GO:0050821,GO:0051082","protein binding|cytoplasm|hemoglobin complex|protein folding|hemoglobin metabolic process|hemopoiesis|erythrocyte differentiation|hemoglobin binding|protein stabilization|unfolded protein binding"]
["AIDA",21.4018757598804,17.1506782485863,15.6693582381398,15.0162208424128,20.0187639034924,16.4812720220561,16.2058381908697,16.0642657347994,19.8686287633276,10.9085253548088,12.8415456666025,15.2967000135296,20.8872386356143,14.573100470164,19.7350927739864,18.1014932020969,15.8375409718132,14.7637721010147,19.3948527334574,20.0664208288179,16.3175174440702,17.8886432496008,24.7600798688794,19.7494001273519,17.4184233100723,15.5401417323603,20.7803467280728,14.5322305563804,64853,"axin interactor%2C dorsalization associated","protein_coding",null,null,"GO:0005515,GO:0005575,GO:0005737,GO:0009953,GO:0016020,GO:0019904,GO:0031333,GO:0035091,GO:0043508,GO:0046329,GO:0048264","protein binding|cellular_component|cytoplasm|dorsal/ventral pattern formation|membrane|protein domain specific binding|negative regulation of protein-containing complex assembly|phosphatidylinositol binding|negative regulation of JUN kinase activity|negative regulation of JNK cascade|determination of ventral identity"]
["AIF1L",0,0,0,0,0,0.00696759147179889,0,0.00727585483623392,0.0447800139174536,0.0428774407009828,0.0209337423749136,0.0223948738373859,0.0141123708644704,0.0141477847710412,0.00690039344280636,0,0,0.0137306009195844,6.85755822087066E-3,0.0142701173927408,0.0280128489060556,0,0,0.0144979269241258,0.0220685530256068,0.0282006639072716,0,0.0348774583780113,83543,"allograft inflammatory factor 1 like","protein_coding",null,null,"GO:0005509,GO:0005737,GO:0005884,GO:0005925,GO:0015629,GO:0032587,GO:0051015,GO:0051017,GO:0070062,GO:0097178","calcium ion binding|cytoplasm|actin filament|focal adhesion|actin cytoskeleton|ruffle membrane|actin filament binding|actin filament bundle assembly|extracellular exosome|ruffle assembly"]
["AIFM1",11.5118500225321,11.2773704637663,11.9042882418893,11.9834119071871,10.8547733792234,11.7334218665668,11.4538690035898,11.4203205546672,9.82977838859793,9.50116236420777,11.5295392086576,10.7195772229583,8.09488100283342,8.59585753187901,9.58065854647108,8.93116450858842,10.7528735443797,12.0043288231722,12.6975022574351,10.9003523881046,9.72341441496324,11.453617310732,9.20792015479356,10.3355282669614,10.3551112900605,10.5231507000627,9.95264404595112,11.0278609462027,9131,"apoptosis inducing factor mitochondria associated 1","protein_coding","hsa04210,hsa04217","Apoptosis|Necroptosis","GO:0002931,GO:0003677,GO:0003954,GO:0005515,GO:0005634,GO:0005737,GO:0005739,GO:0005743,GO:0005758,GO:0005829,GO:0006915,GO:0006919,GO:0009636,GO:0016174,GO:0016651,GO:0030261,GO:0033108,GO:0043065,GO:0043525,GO:0045041,GO:0046983,GO:0048471,GO:0051402,GO:0060545,GO:0070059,GO:0070301,GO:0071392,GO:0071732,GO:0071949,GO:0072572,GO:0090650,GO:1902065,GO:1902510,GO:1904045","response to ischemia|DNA binding|NADH dehydrogenase activity|protein binding|nucleus|cytoplasm|mitochondrion|mitochondrial inner membrane|mitochondrial intermembrane space|cytosol|apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|response to toxic substance|NAD(P)H oxidase H2O2-forming activity|oxidoreductase activity, acting on NAD(P)H|chromosome condensation|mitochondrial respiratory chain complex assembly|positive regulation of apoptotic process|positive regulation of neuron apoptotic process|protein import into mitochondrial intermembrane space|protein dimerization activity|perinuclear region of cytoplasm|neuron apoptotic process|positive regulation of necroptotic process|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|cellular response to hydrogen peroxide|cellular response to estradiol stimulus|cellular response to nitric oxide|FAD binding|poly-ADP-D-ribose binding|cellular response to oxygen-glucose deprivation|response to L-glutamate|regulation of apoptotic DNA fragmentation|cellular response to aldosterone","WP2507,WP5413,WP384,WP1772","Nanomaterial induced apoptosis|IL-24 Signaling pathway|Apoptosis modulation by HSP70|Apoptosis modulation and signaling"]
["AIFM2",16.4985442306875,15.5293856595912,18.5308367611601,16.7625585807105,16.9697506203371,17.4538033102547,19.0969316610134,19.8775495960054,10.8993083571788,12.6045802341695,12.816802217854,11.705687045559,10.1821363109458,12.6653972912266,11.3718109991996,10.7302068045879,14.5074417499025,15.2257679414613,13.6996503198373,14.1631301785362,13.7229830003255,14.8983506577318,11.2571727236036,13.5329297492417,13.6564244168179,15.6929143302659,11.5000326962726,15.5024621144633,84883,"apoptosis inducing factor mitochondria associated 2","protein_coding","hsa04115","p53 signaling pathway","GO:0003677,GO:0004174,GO:0005515,GO:0005615,GO:0005634,GO:0005737,GO:0005739,GO:0005741,GO:0005811,GO:0005829,GO:0005886,GO:0006743,GO:0008637,GO:0016655,GO:0022904,GO:0042373,GO:0043065,GO:0050660,GO:0110076,GO:1900407,GO:1990748","DNA binding|electron-transferring-flavoprotein dehydrogenase activity|protein binding|extracellular space|nucleus|cytoplasm|mitochondrion|mitochondrial outer membrane|lipid droplet|cytosol|plasma membrane|ubiquinone metabolic process|apoptotic mitochondrial changes|oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor|respiratory electron transport chain|vitamin K metabolic process|positive regulation of apoptotic process|flavin adenine dinucleotide binding|negative regulation of ferroptosis|regulation of cellular response to oxidative stress|cellular detoxification","WP5186,WP4313,WP5158,WP1772","Vitamin K metabolism and activation of dependent proteins|Ferroptosis|Urotensin-II-mediated signaling pathway|Apoptosis modulation and signaling","R-HSA-212436,R-HSA-3700989,R-HSA-5633008,R-HSA-6803204,R-HSA-73857,R-HSA-74160","Generic Transcription Pathway|Transcriptional Regulation by TP53|TP53 Regulates Transcription of Cell Death Genes|TP53 Regulates Transcription of Genes Involved in Cytochrome C Release|RNA Polymerase II Transcription|Gene expression (Transcription)"]
["AIFM3",0.203187552024445,0.150317279246656,0.180161982754417,0.487171720213243,0.19854632276672,0.243804428723636,0.410739660765936,0.442766844556747,0.22708792652444,0.173951694100134,0.127390763899599,0.147639237362632,0.139554682487034,0.172190626710863,0.136473484887061,0.214058515470242,0.0868233436915865,0.25066971427563,0.229521439849794,0.119404669465264,0.0426175377201424,0.0751089333025537,0.0780075508911087,0.121310857133341,0.26859314285437,0.10725817836591,0.185697481036032,0.275917501128157,150209,"apoptosis inducing factor mitochondria associated 3","protein_coding",null,null,"GO:0005634,GO:0005737,GO:0005739,GO:0005743,GO:0005783,GO:0005829,GO:0016651,GO:0046872,GO:0050660,GO:0051537,GO:0097194","nucleus|cytoplasm|mitochondrion|mitochondrial inner membrane|endoplasmic reticulum|cytosol|oxidoreductase activity, acting on NAD(P)H|metal ion binding|flavin adenine dinucleotide binding|2 iron, 2 sulfur cluster binding|execution phase of apoptosis","WP4657","22q11.2 copy number variation syndrome"]
["AIG1",5.40891574204739,5.30268525191924,5.2213761584212,5.24653019581432,5.1676215029562,5.40612979106462,5.13141011773221,5.82911105358935,5.56991846101854,4.16242541133747,4.73926036695642,5.56035330645092,5.74479333460819,6.34125721415569,5.89437064041448,5.80126857228873,6.85312771041427,5.6092048470689,6.03348912109263,5.1961782572979,5.84572322973811,5.77768240345614,6.11961150274936,6.4406439100422,6.01558459719344,5.83403090441405,6.92612465855615,5.76972039357358,51390,"androgen induced 1","protein_coding",null,null,"GO:0005515,GO:0005886,GO:0012505,GO:0016020,GO:0016787,GO:0042758","protein binding|plasma membrane|endomembrane system|membrane|hydrolase activity|long-chain fatty acid catabolic process"]
["AIM2",0.0189232820184226,0.0539975424220551,0.151009763010722,0.108891172843732,0.0277365519344171,0.062194741565222,0.079448630551264,0.0278341670270668,0.0475856413250582,0.0637894111657127,0.0978793900232446,0.0475959849369504,0.0359917468238828,0.0631436143405315,0.0439963660542567,0.00897107291932148,0.0272903840911954,0.0350180927629697,0.0874465040941493,0.0545910879127703,0.0267911583210863,0.0269809155182016,0.177473730082303,0.110925170618496,0.0656634341867564,0.0629318255375416,0.119026130970259,0.0444751864820341,9447,"absent in melanoma 2","protein_coding","hsa04621,hsa04623","NOD-like receptor signaling pathway|Cytosolic DNA-sensing pathway","GO:0002218,GO:0002221,GO:0002230,GO:0003690,GO:0005515,GO:0005654,GO:0005737,GO:0005739,GO:0005829,GO:0006954,GO:0006955,GO:0006974,GO:0007420,GO:0032088,GO:0032731,GO:0033209,GO:0035458,GO:0035591,GO:0035861,GO:0038187,GO:0042802,GO:0043029,GO:0045087,GO:0050729,GO:0050795,GO:0051092,GO:0051607,GO:0051898,GO:0070050,GO:0070269,GO:0071466,GO:0097169,GO:0140608,GO:0140970,GO:1904270,GO:2001056","activation of innate immune response|pattern recognition receptor signaling pathway|positive regulation of defense response to virus by host|double-stranded DNA binding|protein binding|nucleoplasm|cytoplasm|mitochondrion|cytosol|inflammatory response|immune response|DNA damage response|brain development|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta production|tumor necrosis factor-mediated signaling pathway|cellular response to interferon-beta|signaling adaptor activity|site of double-strand break|pattern recognition receptor activity|identical protein binding|T cell homeostasis|innate immune response|positive regulation of inflammatory response|regulation of behavior|positive regulation of NF-kappaB transcription factor activity|defense response to virus|negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction|neuron cellular homeostasis|pyroptosis|cellular response to xenobiotic stimulus|AIM2 inflammasome complex|cysteine-type endopeptidase activator activity|AIM2 inflammasome complex assembly|pyroptosome complex assembly|positive regulation of cysteine-type endopeptidase activity","WP1433,WP4655","Nucleotide-binding oligomerization domain (NOD) pathway|Cytosolic DNA-sensing pathway","R-HSA-168249,R-HSA-168249,R-HSA-168256,R-HSA-168256,R-HSA-168643,R-HSA-168643,R-HSA-1834949,R-HSA-622312,R-HSA-622312,R-HSA-844615,R-HSA-844615","Innate Immune System|Innate Immune System|Immune System|Immune System|Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways|Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways|Cytosolic sensors of pathogen-associated DNA |Inflammasomes|Inflammasomes|The AIM2 inflammasome|The AIM2 inflammasome"]
["AIMP1",9.19645126055354,9.07662221372963,10.2675246245445,9.51451802718325,8.85285778535746,8.57605372307806,10.1398570872133,9.14307548651866,9.68564158072262,7.11572067230312,8.27605140502726,9.31655133107674,9.02297371572692,8.56358861848057,9.60743248203089,8.59438790585034,10.2037968324124,8.95167895836146,11.4969234747974,9.81589363545298,11.1263315324396,9.73738566363864,15.1540203314162,11.9573244677883,10.8290963971266,10.6512699590556,14.9069932956573,11.1679342614842,9255,"aminoacyl tRNA synthetase complex interacting multifunctional protein 1","protein_coding",null,null,"GO:0000049,GO:0001525,GO:0001937,GO:0005125,GO:0005515,GO:0005615,GO:0005634,GO:0005783,GO:0005794,GO:0005829,GO:0006412,GO:0006915,GO:0006954,GO:0007165,GO:0007267,GO:0009986,GO:0016020,GO:0017101,GO:0042803,GO:0050900,GO:0051020,GO:0051607,GO:0070094","tRNA binding|angiogenesis|negative regulation of endothelial cell proliferation|cytokine activity|protein binding|extracellular space|nucleus|endoplasmic reticulum|Golgi apparatus|cytosol|translation|apoptotic process|inflammatory response|signal transduction|cell-cell signaling|cell surface|membrane|aminoacyl-tRNA synthetase multienzyme complex|protein homodimerization activity|leukocyte migration|GTPase binding|defense response to virus|positive regulation of glucagon secretion","WP4352","Ciliary landscape","R-HSA-1430728,R-HSA-2408522,R-HSA-379716,R-HSA-379724,R-HSA-392499,R-HSA-71291,R-HSA-72766","Metabolism|Selenoamino acid metabolism|Cytosolic tRNA aminoacylation|tRNA Aminoacylation|Metabolism of proteins|Metabolism of amino acids and derivatives|Translation"]
["AIMP2",13.0799182251582,14.8398854729963,17.5022494310682,16.5831450836227,13.677240569224,14.8548270457235,15.6370718782416,16.8727464477054,13.0959391238821,14.9567894688007,15.2513089299603,13.8271705171207,13.7585097979845,14.092134073335,15.3287514458188,13.477177792363,13.6312455273177,13.3193251694347,15.0886202771801,12.1718128862424,12.6416131248911,11.905347088509,13.9491149072291,12.1775090591664,13.4103602763675,14.1595198958449,14.4436828766989,14.0776069474089,7965,"aminoacyl tRNA synthetase complex interacting multifunctional protein 2","protein_coding",null,null,"GO:0005515,GO:0005634,GO:0005829,GO:0006412,GO:0006915,GO:0008285,GO:0016020,GO:0016567,GO:0017101,GO:0031398,GO:0060090,GO:0060510,GO:0065003","protein binding|nucleus|cytosol|translation|apoptotic process|negative regulation of cell population proliferation|membrane|protein ubiquitination|aminoacyl-tRNA synthetase multienzyme complex|positive regulation of protein ubiquitination|molecular adaptor activity|type II pneumocyte differentiation|protein-containing complex assembly","WP3,WP4357,WP12","Transcriptional activation by NRF2 in response to phytochemicals|NRF2-ARE regulation|Osteoclast signaling","R-HSA-1430728,R-HSA-2408522,R-HSA-379716,R-HSA-379724,R-HSA-392499,R-HSA-71291,R-HSA-72766","Metabolism|Selenoamino acid metabolism|Cytosolic tRNA aminoacylation|tRNA Aminoacylation|Metabolism of proteins|Metabolism of amino acids and derivatives|Translation"]
["AIP",27.4345453281409,26.505746139949,33.6225609344263,32.2898271333797,29.039360164889,29.2833990213215,33.6003887591583,32.0920298197482,28.5577041246213,35.2504594716793,40.2100524020563,33.1589757158963,27.5133675679492,33.2754197165317,30.6368581691028,31.0740917292158,37.4880784020199,37.4053164364705,45.0496708545396,33.5928202084835,35.0401053609236,37.634974288674,38.965527569592,35.3652238514622,33.5630731909202,42.7816097514874,45.5405580449791,41.19700628002,9049,"aryl hydrocarbon receptor interacting protein","protein_coding","hsa05207,hsa04934","Chemical carcinogenesis - receptor activation|Cushing syndrome","GO:0003713,GO:0003755,GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0006626,GO:0006805,GO:0010738,GO:0017162,GO:0022417,GO:0034751,GO:0036004,GO:0045893,GO:0051082","transcription coactivator activity|peptidyl-prolyl cis-trans isomerase activity|protein binding|nucleoplasm|cytoplasm|cytosol|plasma membrane|protein targeting to mitochondrion|xenobiotic metabolic process|regulation of protein kinase A signaling|aryl hydrocarbon receptor binding|protein maturation by protein folding|aryl hydrocarbon receptor complex|GAF domain binding|positive regulation of DNA-templated transcription|unfolded protein binding","WP2586,WP2882,WP2873","Aryl hydrocarbon receptor pathway|Nuclear receptors meta-pathway|Aryl hydrocarbon receptor pathway","R-HSA-1280215,R-HSA-1430728,R-HSA-168256,R-HSA-211859,R-HSA-211945,R-HSA-447115,R-HSA-449147,R-HSA-8937144,R-HSA-8950505,R-HSA-9020591","Cytokine Signaling in Immune system|Metabolism|Immune System|Biological oxidations|Phase I - Functionalization of compounds|Interleukin-12 family signaling|Signaling by Interleukins|Aryl hydrocarbon receptor signalling|Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation|Interleukin-12 signaling"]
["AIPL1",0,0,0,0,0,0,0,0,0.00725757452543313,0,0,0.0290366083694586,0,0,0,0,0,0,0,0,0.0136202730294031,0,0.0142461021358188,0,0,0,0,0.00678318020810038,23746,"aryl hydrocarbon receptor interacting protein like 1","protein_coding","hsa05207,hsa04934","Chemical carcinogenesis - receptor activation|Cushing syndrome","GO:0001895,GO:0001917,GO:0001918,GO:0003755,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006915,GO:0007601,GO:0007603,GO:0016607,GO:0018343,GO:0022400,GO:0043066,GO:0051082","retina homeostasis|photoreceptor inner segment|farnesylated protein binding|peptidyl-prolyl cis-trans isomerase activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|apoptotic process|visual perception|phototransduction, visible light|nuclear speck|protein farnesylation|regulation of rhodopsin mediated signaling pathway|negative regulation of apoptotic process|unfolded protein binding"]
["AIRE",0,0.0381261458142342,0.0094079775818401,0.00961062426988207,0.00979199956148135,0.00941013376098341,0,0.00982646119704008,0.0100796648427576,0.0386056361999183,0.0471203754944616,0.0302455675283357,0.0190595700188182,0.0191073985402203,0,0,0.0578069176771864,0.0927198385517665,0.00926152751539893,0.06745415528156,0.0283747249281691,0.0285756982570098,0.0197856645276651,0.0881112856204726,0.0397398032922079,0.095216553880221,0,0.0376832137657443,326,"autoimmune regulator","protein_coding","hsa04120,hsa05340","Ubiquitin mediated proteolysis|Primary immunodeficiency","GO:0000977,GO:0001673,GO:0001674,GO:0002458,GO:0002509,GO:0003682,GO:0005515,GO:0005634,GO:0005737,GO:0006355,GO:0006366,GO:0006417,GO:0006955,GO:0006959,GO:0008270,GO:0016604,GO:0032722,GO:0042393,GO:0042802,GO:0045060,GO:0045182,GO:0045893,GO:0045944,GO:0097536,GO:2000410","RNA polymerase II transcription regulatory region sequence-specific DNA binding|male germ cell nucleus|female germ cell nucleus|peripheral T cell tolerance induction|central tolerance induction to self antigen|chromatin binding|protein binding|nucleus|cytoplasm|regulation of DNA-templated transcription|transcription by RNA polymerase II|regulation of translation|immune response|humoral immune response|zinc ion binding|nuclear body|positive regulation of chemokine production|histone binding|identical protein binding|negative thymic T cell selection|translation regulator activity|positive regulation of DNA-templated transcription|positive regulation of transcription by RNA polymerase II|thymus epithelium morphogenesis|regulation of thymocyte migration","WP5316","Primary ovarian insufficiency"]
["AJAP1",0.0453982037185446,0.00588834870858283,0.00193733902588608,0.0158325525750487,0.0262134444358113,0.00968891518680447,0.0115516674801883,0.00809406127843154,0,0,0,0.00207610749575705,0,0,0,0,0.0019839828593691,0,0,0,0,7.84593924941758E-3,0,0.00201603645852213,0,0,0,0,55966,"adherens junctions associated protein 1","protein_coding",null,null,"GO:0001953,GO:0005515,GO:0005886,GO:0005912,GO:0007155,GO:0008013,GO:0009898,GO:0009986,GO:0016323,GO:0016324,GO:0030860,GO:0044291,GO:0044877,GO:0061045","negative regulation of cell-matrix adhesion|protein binding|plasma membrane|adherens junction|cell adhesion|beta-catenin binding|cytoplasmic side of plasma membrane|cell surface|basolateral plasma membrane|apical plasma membrane|regulation of polarized epithelial cell differentiation|cell-cell contact zone|protein-containing complex binding|negative regulation of wound healing"]
["AJM1",1.0859138838842,1.31457998024499,1.13398354515105,1.39231900506154,1.1689225844462,1.15605581241137,1.20277444956202,1.34956135436212,0.911208650283248,1.10180336015848,1.1195403303068,0.934776121226173,0.452839288534137,0.764007807636858,0.664261721985999,0.809373600135845,1.10545456316325,1.13371075320114,1.07339547679548,0.921386311987456,1.16196597242828,1.52898248185018,0.728067274082966,0.98715516174825,0.89812640314208,1.19182736894794,0.781090000193276,1.08093673610031,389813,"apical junction component 1 homolog","protein_coding",null,null,"GO:0005886,GO:0005912,GO:0005929,GO:0016324,GO:0043296,GO:0045216","plasma membrane|adherens junction|cilium|apical plasma membrane|apical junction complex|cell-cell junction organization"]
["AJUBA",22.0473105572515,23.0476502760804,23.9585849398246,19.9307638530895,23.0423478005735,23.3483769166951,23.038121871969,21.5580254803015,21.2360928670153,22.1349391663405,19.0559662023977,21.57913771587,21.0752364534543,19.6224657872489,19.9259281305953,20.4771418354891,24.5134913086187,23.2271628214006,20.6137155821166,21.7987633117176,25.1574624235352,22.4958880513564,20.9212687693212,23.8512148035876,23.921377953826,20.6292866751929,20.683755064857,21.7186182350338,84962,"ajuba LIM protein","protein_coding","hsa04390,hsa04392","Hippo signaling pathway|Hippo signaling pathway - multiple species","GO:0000122,GO:0000932,GO:0001666,GO:0003682,GO:0003714,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0005794,GO:0005815,GO:0005829,GO:0005886,GO:0005911,GO:0005912,GO:0005925,GO:0006355,GO:0007010,GO:0007049,GO:0007249,GO:0008104,GO:0016339,GO:0030027,GO:0030032,GO:0030334,GO:0031328,GO:0031334,GO:0035195,GO:0035278,GO:0035313,GO:0035331,GO:0043123,GO:0045294,GO:0046474,GO:0046872,GO:0048041,GO:0051015,GO:1900037,GO:2000637","negative regulation of transcription by RNA polymerase II|P-body|response to hypoxia|chromatin binding|transcription corepressor activity|protein binding|nucleus|nucleoplasm|transcription regulator complex|Golgi apparatus|microtubule organizing center|cytosol|plasma membrane|cell-cell junction|adherens junction|focal adhesion|regulation of DNA-templated transcription|cytoskeleton organization|cell cycle|canonical NF-kappaB signal transduction|protein localization|calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules|lamellipodium|lamellipodium assembly|regulation of cell migration|positive regulation of cellular biosynthetic process|positive regulation of protein-containing complex assembly|miRNA-mediated post-transcriptional gene silencing|miRNA-mediated gene silencing by inhibition of translation|wound healing, spreading of epidermal cells|negative regulation of hippo signaling|positive regulation of canonical NF-kappaB signal transduction|alpha-catenin binding|glycerophospholipid biosynthetic process|metal ion binding|focal adhesion assembly|actin filament binding|regulation of cellular response to hypoxia|positive regulation of miRNA-mediated gene silencing","WP3656,WP4674,WP4541,WP5087","Interleukin-1 induced activation of NF-kB|Head and neck squamous cell carcinoma|Hippo-Merlin signaling dysregulation|Pleural mesothelioma","R-HSA-1234174,R-HSA-1234174,R-HSA-1234176,R-HSA-1234176,R-HSA-1266738,R-HSA-1640170,R-HSA-2262752,R-HSA-2262752,R-HSA-2565942,R-HSA-453274,R-HSA-5617472,R-HSA-5619507,R-HSA-69275,R-HSA-69278,R-HSA-8953897,R-HSA-8953897","Cellular response to hypoxia|Cellular response to hypoxia|Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha|Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha|Developmental Biology|Cell Cycle|Cellular responses to stress|Cellular responses to stress|Regulation of PLK1 Activity at G2/M Transition|Mitotic G2-G2/M phases|Activation of anterior HOX genes in hindbrain development during early embryogenesis|Activation of HOX genes during differentiation|G2/M Transition|Cell Cycle, Mitotic|Cellular responses to stimuli|Cellular responses to stimuli"]
["AJUBA-DT",0.376581304455962,0.558112025674093,0.748206248297153,0.403159131165423,0.684612834837812,0.476988001750692,0.555618442493591,0.455152232898637,0.299508169759135,0.38800044049528,0.444750210807374,0.54628067493782,0.458067476329461,0.467566360639829,0.456098520192355,0.381967183355671,0.210500065723997,0.421366179877228,0.420890990530865,0.48003089340581,0.405032758585875,0.258060155691146,0.389060216223825,0.325129435279933,0.277842939196983,0.291248815718739,0.313562791622131,0.312863719227938,107984660,null,"non_coding"]
["AK1",17.2682719148239,15.5321459141832,16.4947437697691,20.2642096505765,15.8960116928538,16.5234715034392,16.0698311328979,18.5310142717348,17.4140779976414,19.1220285651267,20.7203337371414,18.754272213187,15.8745743620106,19.4096708058919,15.128774857708,16.5744580285374,18.7138818219714,18.779970768533,19.3235199697026,18.1639022221642,19.1906604347739,18.4343293913568,16.4705907358124,17.796350564401,18.7707253194983,22.1044729351703,18.4926097977295,22.0451752331676,203,"adenylate kinase 1","protein_coding","hsa00230,hsa00730","Purine metabolism|Thiamine metabolism","GO:0001520,GO:0004017,GO:0004550,GO:0005524,GO:0005737,GO:0005829,GO:0006172,GO:0009142,GO:0015949,GO:0016310,GO:0046033,GO:0046034,GO:0046899,GO:0046940,GO:0070062","outer dense fiber|adenylate kinase activity|nucleoside diphosphate kinase activity|ATP binding|cytoplasm|cytosol|ADP biosynthetic process|nucleoside triphosphate biosynthetic process|nucleobase-containing small molecule interconversion|phosphorylation|AMP metabolic process|ATP metabolic process|nucleoside triphosphate adenylate kinase activity|nucleoside monophosphate phosphorylation|extracellular exosome","WP5413","IL-24 Signaling pathway","R-HSA-1430728,R-HSA-15869,R-HSA-499943","Metabolism|Metabolism of nucleotides|Interconversion of nucleotide di- and triphosphates"]
["AK2",19.8765832261174,18.6091517416763,19.3168448471946,19.522195509076,17.2754721705915,18.1369052650659,20.9760215089276,19.7408543235072,19.9843076603438,17.4549209945372,18.7630354666991,18.9584910705599,18.4051313756223,18.1580405596036,19.0245838365284,17.3376719033058,26.7153121365059,22.5222896908355,26.8102499213252,22.9170536170108,26.8321865589217,24.2778213099447,27.90889908285,28.2760840106039,25.8710719246479,26.686387330167,30.8563758672501,27.4985481137388,204,"adenylate kinase 2","protein_coding","hsa00230,hsa00730","Purine metabolism|Thiamine metabolism","GO:0004017,GO:0005515,GO:0005524,GO:0005737,GO:0005739,GO:0005758,GO:0006172,GO:0015949,GO:0016310,GO:0046033,GO:0046034,GO:0046940,GO:0070062,GO:0097226","adenylate kinase activity|protein binding|ATP binding|cytoplasm|mitochondrion|mitochondrial intermembrane space|ADP biosynthetic process|nucleobase-containing small molecule interconversion|phosphorylation|AMP metabolic process|ATP metabolic process|nucleoside monophosphate phosphorylation|extracellular exosome|sperm mitochondrial sheath",null,null,"R-HSA-1430728,R-HSA-15869,R-HSA-499943","Metabolism|Metabolism of nucleotides|Interconversion of nucleotide di- and triphosphates"]
["AK3",31.0041252971467,27.8602482818861,24.5619686343625,26.5454169589847,35.8498875639567,28.0155834564287,25.8684741074915,27.1825598269846,28.0571433557096,18.348985268909,20.8870065779835,23.5882602074088,29.9502252131258,23.1380439565369,24.1807438405207,26.2039198344502,21.8183024401901,22.0745913035258,21.6744769471783,26.5532039043413,26.6993068770026,25.6285511594009,28.1618587767957,24.8597638773442,24.9137540549872,24.9381750078969,22.9247877030203,20.256730493507,50808,"adenylate kinase 3","protein_coding","hsa00230","Purine metabolism","GO:0004017,GO:0005515,GO:0005524,GO:0005525,GO:0005737,GO:0005739,GO:0005759,GO:0006172,GO:0007596,GO:0009142,GO:0016310,GO:0046033,GO:0046039,GO:0046041,GO:0046051,GO:0046899","adenylate kinase activity|protein binding|ATP binding|GTP binding|cytoplasm|mitochondrion|mitochondrial matrix|ADP biosynthetic process|blood coagulation|nucleoside triphosphate biosynthetic process|phosphorylation|AMP metabolic process|GTP metabolic process|ITP metabolic process|UTP metabolic process|nucleoside triphosphate adenylate kinase activity",null,null,"R-HSA-109582,R-HSA-983231","Hemostasis|Factors involved in megakaryocyte development and platelet production"]
["AK4",0.175622197384245,0.102272967930085,0.0740279368825019,0.219992697022058,0.175112876082867,0.111067354602113,0.110350601996457,0.115981247235905,0.486694626731479,0.310677586890048,0.498858234060764,0.569736786371193,0.494228512554186,0.65265192766785,0.566646987662762,0.533532524837397,1.05100575296387,0.742843583536131,0.371002926451188,0.909895016140571,0.889698472939407,1.06974911535548,0.442290233840408,0.815871271378564,0.86702623616785,0.967180408221429,0.322551282905168,0.764875043936193,205,"adenylate kinase 4","protein_coding","hsa00230,hsa00730","Purine metabolism|Thiamine metabolism","GO:0002082,GO:0004017,GO:0004550,GO:0005515,GO:0005524,GO:0005525,GO:0005737,GO:0005739,GO:0005759,GO:0006172,GO:0009142,GO:0009188,GO:0015949,GO:0016310,GO:0046033,GO:0046034,GO:0046039,GO:0046899,GO:0046940,GO:0050145,GO:0071456","regulation of oxidative phosphorylation|adenylate kinase activity|nucleoside diphosphate kinase activity|protein binding|ATP binding|GTP binding|cytoplasm|mitochondrion|mitochondrial matrix|ADP biosynthetic process|nucleoside triphosphate biosynthetic process|ribonucleoside diphosphate biosynthetic process|nucleobase-containing small molecule interconversion|phosphorylation|AMP metabolic process|ATP metabolic process|GTP metabolic process|nucleoside triphosphate adenylate kinase activity|nucleoside monophosphate phosphorylation|nucleoside monophosphate kinase activity|cellular response to hypoxia","WP5097","CCL18 signaling pathway","R-HSA-1430728,R-HSA-15869,R-HSA-499943","Metabolism|Metabolism of nucleotides|Interconversion of nucleotide di- and triphosphates"]
["AK5",21.3096917320905,20.7058215877069,22.6477468818008,21.8069324047924,20.7468821198238,21.4762563800744,23.6431620975068,22.052454280814,13.8213639015159,12.8930675306613,13.9873844990948,14.2589490478684,14.2997127404937,15.9494644155229,17.6500857478155,15.5521067040889,20.4917191915039,19.3318387103526,22.5793286567207,20.3309403160363,19.0076248517304,18.7612570518839,22.7507721485001,21.244793710392,19.7997388347478,20.0964385767563,22.1611704077153,19.8323620581358,26289,"adenylate kinase 5","protein_coding","hsa00230,hsa00730","Purine metabolism|Thiamine metabolism","GO:0004017,GO:0004550,GO:0005524,GO:0005737,GO:0005829,GO:0006172,GO:0006173,GO:0009220,GO:0016310,GO:0034451,GO:0046034,GO:0046940","adenylate kinase activity|nucleoside diphosphate kinase activity|ATP binding|cytoplasm|cytosol|ADP biosynthetic process|dADP biosynthetic process|pyrimidine ribonucleotide biosynthetic process|phosphorylation|centriolar satellite|ATP metabolic process|nucleoside monophosphate phosphorylation",null,null,"R-HSA-1430728,R-HSA-15869,R-HSA-499943","Metabolism|Metabolism of nucleotides|Interconversion of nucleotide di- and triphosphates"]
["AK6",11.8703511905474,10.1758980706642,11.9342870134318,11.6149269255864,9.66111207570414,9.79230898162178,9.81322952485977,10.2844816459233,10.307665288309,6.19390204427117,10.0894337120616,8.46561184033536,10.5169729949992,7.20558744225639,10.3406665214657,9.75899215261741,11.5570872204854,9.57903433501837,14.8314535281716,12.079439605302,12.8206096416433,12.2258539268898,19.4915264713927,13.8723704701797,12.6623551041852,13.2920504666715,15.2380802931444,11.7386676727713,102157402,"adenylate kinase 6","protein_coding","hsa00230,hsa03008","Purine metabolism|Ribosome biogenesis in eukaryotes","GO:0004017,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005813,GO:0015030,GO:0015949,GO:0016020,GO:0016310,GO:0016607,GO:0016887,GO:0046940,GO:0050145","adenylate kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|nucleolus|cytoplasm|centrosome|Cajal body|nucleobase-containing small molecule interconversion|membrane|phosphorylation|nuclear speck|ATP hydrolysis activity|nucleoside monophosphate phosphorylation|nucleoside monophosphate kinase activity",null,null,"R-HSA-1430728,R-HSA-15869,R-HSA-499943","Metabolism|Metabolism of nucleotides|Interconversion of nucleotide di- and triphosphates"]
["AK7",0.0073913395215912,0.070303902001844,0.0138785081958595,0.0283548991346123,0.0216675175380188,0.0138816889591693,0.0275842121001189,0.00724792449137313,0.052042799284104,0.0213564219998177,0.0208533825193477,0.0223089050318681,0.0210872950441271,0.0140934746567569,0.0274956176339078,0.0911054641384452,0.0568506017920232,0.0136778922788183,0.102468504317616,0.0142153376714635,0.0418579709661502,0.0140514812743545,0.0072968792952316,0.0216634090411362,0.0732794563038384,0.014046203999879,0.064372171525773,0.0486410004941709,122481,"adenylate kinase 7","protein_coding","hsa00230,hsa00730","Purine metabolism|Thiamine metabolism","GO:0004017,GO:0004127,GO:0004550,GO:0005524,GO:0005737,GO:0005829,GO:0016310,GO:0030030,GO:0031514,GO:0046940","adenylate kinase activity|cytidylate kinase activity|nucleoside diphosphate kinase activity|ATP binding|cytoplasm|cytosol|phosphorylation|cell projection organization|motile cilium|nucleoside monophosphate phosphorylation","WP4803","Ciliopathies","R-HSA-1430728,R-HSA-15869,R-HSA-499943","Metabolism|Metabolism of nucleotides|Interconversion of nucleotide di- and triphosphates"]
["AK8",0.0313288239493112,0.0851397411923378,0.0546234394881202,0.0987231153208706,0.0393598388483253,0.0672442565287607,0.112742395039291,0.057053187458159,0.0990394430341027,0.137936790805618,0.101015820751201,0.144088685197805,0.102148915857123,0.162141646918588,0.10821805808079,0.157009415514599,0.0387266997887178,0.0993855682699991,0.0785915110928174,0.051645362597869,0.0844850407402457,0.0893376055420047,0.0706935913390926,0.0699597788681377,0.106491852089695,0.161597810686305,0.0692944629452267,0.155678659559377,158067,"adenylate kinase 8","protein_coding","hsa00230,hsa00730","Purine metabolism|Thiamine metabolism","GO:0004017,GO:0004127,GO:0004550,GO:0005515,GO:0005524,GO:0005737,GO:0005829,GO:0005930,GO:0016208,GO:0016310,GO:0021591,GO:0036126,GO:0046940,GO:0097729","adenylate kinase activity|cytidylate kinase activity|nucleoside diphosphate kinase activity|protein binding|ATP binding|cytoplasm|cytosol|axoneme|AMP binding|phosphorylation|ventricular system development|sperm flagellum|nucleoside monophosphate phosphorylation|9+2 motile cilium",null,null,"R-HSA-1430728,R-HSA-15869,R-HSA-499943","Metabolism|Metabolism of nucleotides|Interconversion of nucleotide di- and triphosphates"]
["AK9",0.130796932763741,0.186614375844236,0.192274002663783,0.171657297180757,0.154716468842201,0.195550305679786,0.221585069447431,0.158636211344158,0.166186084976935,0.104425990659518,0.11167736570934,0.131592581784948,0.15875673897115,0.159155126766893,0.174457964768626,0.102802206797564,0.167119554190499,0.216565317855955,0.257676592010505,0.129087028220984,0.142945474153444,0.0965172502153701,0.258250734599749,0.242118989536177,0.19963142900716,0.109563171204955,0.24647801126551,0.156941214452781,221264,"adenylate kinase 9","protein_coding","hsa00230,hsa00240","Purine metabolism|Pyrimidine metabolism","GO:0004017,GO:0004550,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0016310,GO:0016887,GO:0031965,GO:0046940,GO:0050145","adenylate kinase activity|nucleoside diphosphate kinase activity|ATP binding|nucleus|nucleoplasm|cytoplasm|cytosol|phosphorylation|ATP hydrolysis activity|nuclear membrane|nucleoside monophosphate phosphorylation|nucleoside monophosphate kinase activity",null,null,"R-HSA-1430728,R-HSA-15869,R-HSA-499943","Metabolism|Metabolism of nucleotides|Interconversion of nucleotide di- and triphosphates"]
["AKAIN1",0,0.00775789200002194,0.00765732517251131,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.00805195727373968,0,0,0,0,0,642597,"A-kinase anchor inhibitor 1","protein_coding",null,null,"GO:0005515,GO:0005829,GO:0008104,GO:0031333,GO:0051018,GO:0065003","protein binding|cytosol|protein localization|negative regulation of protein-containing complex assembly|protein kinase A binding|protein-containing complex assembly"]
["AKAP1",3.45158136947732,3.79159353775228,3.08142674999861,3.41688646101068,2.98477146099019,3.32074971676871,3.59566596981586,2.70457327239585,2.83816203095064,3.40589354872138,2.70335109479557,2.82812687888187,2.83939682342403,2.88185124546278,3.0179450723762,2.33400291386946,2.28018698059475,2.96830945830276,2.57354786776091,2.7540499842807,2.31842083440322,2.4153535997284,1.96504443537526,2.12566457775024,2.56648343718594,2.10761056645593,2.13106329699462,2.35901210448497,8165,"A-kinase anchoring protein 1","protein_coding",null,null,"GO:0003723,GO:0005515,GO:0005739,GO:0005741,GO:0005829,GO:0006915,GO:0016020,GO:0034237,GO:0140374","RNA binding|protein binding|mitochondrion|mitochondrial outer membrane|cytosol|apoptotic process|membrane|protein kinase A regulatory subunit binding|antiviral innate immune response","WP35","G protein signaling pathways","R-HSA-109582,R-HSA-382551,R-HSA-8949215,R-HSA-983231","Hemostasis|Transport of small molecules|Mitochondrial calcium ion transport|Factors involved in megakaryocyte development and platelet production"]
["AKAP10",9.08934651052992,8.59499203244371,7.72366478513065,6.6301716997278,8.74558354139777,7.60706134300083,7.1989515037154,7.65085414943748,6.72018176618442,7.23979201581498,6.45155991251908,7.28233564086343,8.26532350348433,7.22974957785617,8.16304655838484,8.47968863774404,7.9287577500073,7.25597204682318,7.14354861041913,8.73412843364951,7.94652922816043,7.11991807068023,8.23306190466774,8.97078764770407,7.49852822888782,6.71378647264954,6.59348518917235,6.4430829384591,11216,"A-kinase anchoring protein 10","protein_coding",null,null,"GO:0005515,GO:0005739,GO:0005829,GO:0005886,GO:0007165,GO:0008104,GO:0032991,GO:0051018","protein binding|mitochondrion|cytosol|plasma membrane|signal transduction|protein localization|protein-containing complex|protein kinase A binding","WP35,WP5362","G protein signaling pathways|TAR syndrome","R-HSA-109582,R-HSA-983231","Hemostasis|Factors involved in megakaryocyte development and platelet production"]
["AKAP11",8.33441373073153,7.18929010666269,4.63358920433221,3.60462505542011,8.7582534413812,5.60141801536384,4.27410828442798,3.84537969676397,7.02770559940276,3.94628806310344,3.42275426125522,4.83796539022562,8.47698198763268,3.98278604971721,5.84088342088986,6.61467310786442,5.0137419128057,3.86294994958893,3.77252828211454,5.88778320058957,5.43717744286978,4.61511740205405,6.90255022441082,6.24207332467673,6.177964463396,3.18291551933062,5.32664362272722,3.11515712223492,11215,"A-kinase anchoring protein 11","protein_coding",null,null,"GO:0003091,GO:0005515,GO:0005730,GO:0005737,GO:0005815,GO:0005829,GO:0005886,GO:0008104,GO:0008157,GO:0030866,GO:0034237,GO:0035556,GO:0036010,GO:0051018","renal water homeostasis|protein binding|nucleolus|cytoplasm|microtubule organizing center|cytosol|plasma membrane|protein localization|protein phosphatase 1 binding|cortical actin cytoskeleton organization|protein kinase A regulatory subunit binding|intracellular signal transduction|protein localization to endosome|protein kinase A binding","WP35","G protein signaling pathways"]
["AKAP12",10.929123196896,12.4245784327305,8.8540425714133,9.0588679532071,12.9677677954992,11.9623746702038,9.32054166537094,10.3347412266826,11.6419074479692,10.2545496839425,8.48407654479568,9.55978757765515,13.9823696502467,11.4365245584489,12.4490473276584,14.0498990005466,6.09431870441747,5.15486202929191,4.7547113541759,6.09782898924415,6.12170128263956,5.24204933661543,6.32793895354326,6.33651922692161,6.50803897210992,4.93252584261176,5.45524370726606,4.76271190374953,9590,"A-kinase anchoring protein 12","protein_coding",null,null,"GO:0005515,GO:0005516,GO:0005737,GO:0005829,GO:0005856,GO:0005886,GO:0005925,GO:0005938,GO:0007165,GO:0007186,GO:0007193,GO:0008179,GO:0010738,GO:0010739,GO:0032496,GO:0032760,GO:0035733,GO:0043025,GO:0043116,GO:0050804,GO:0051018,GO:0051602,GO:0051770,GO:0061870,GO:0070374,GO:0071347,GO:0071356,GO:0090036,GO:0098685,GO:1900143","protein binding|calmodulin binding|cytoplasm|cytosol|cytoskeleton|plasma membrane|focal adhesion|cell cortex|signal transduction|G protein-coupled receptor signaling pathway|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway|adenylate cyclase binding|regulation of protein kinase A signaling|positive regulation of protein kinase A signaling|response to lipopolysaccharide|positive regulation of tumor necrosis factor production|hepatic stellate cell activation|neuronal cell body|negative regulation of vascular permeability|modulation of chemical synaptic transmission|protein kinase A binding|response to electrical stimulus|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of hepatic stellate cell migration|positive regulation of ERK1 and ERK2 cascade|cellular response to interleukin-1|cellular response to tumor necrosis factor|regulation of protein kinase C signaling|Schaffer collateral - CA1 synapse|positive regulation of oligodendrocyte apoptotic process","WP35","G protein signaling pathways","R-HSA-162582,R-HSA-194315,R-HSA-9012999,R-HSA-9013405,R-HSA-9035034,R-HSA-9716542","Signal Transduction|Signaling by Rho GTPases|RHO GTPase cycle|RHOD GTPase cycle|RHOF GTPase cycle|Signaling by Rho GTPases, Miro GTPases and RHOBTB3"]
["AKAP13",3.54296389390448,3.96862971515037,3.80754717052368,3.03344017174539,4.20086056229355,3.6467153066336,3.093185367158,3.07245208323077,4.21078942456446,4.03379149488551,3.94622332579214,3.94884655014747,4.04131039260531,4.03069442794403,4.39938462535722,4.14747607836072,2.98768822265537,2.84231000494161,1.92810327507966,2.99776984243807,3.06941088487361,2.84280533026065,2.31941480309753,2.90833161932172,3.24177467240945,2.32642587218629,2.14901303995351,2.48600192671786,11214,"A-kinase anchoring protein 13","protein_coding","hsa04928,hsa05163","Parathyroid hormone synthesis, secretion and action|Human cytomegalovirus infection","GO:0005078,GO:0005085,GO:0005515,GO:0005634,GO:0005829,GO:0005938,GO:0007186,GO:0007507,GO:0015629,GO:0016020,GO:0030864,GO:0031267,GO:0035023,GO:0035025,GO:0043123,GO:0043410,GO:0046872,GO:0051018,GO:0051056,GO:0055007,GO:0060090,GO:0060297,GO:0060348,GO:0071875,GO:0086023","MAP-kinase scaffold activity|guanyl-nucleotide exchange factor activity|protein binding|nucleus|cytosol|cell cortex|G protein-coupled receptor signaling pathway|heart development|actin cytoskeleton|membrane|cortical actin cytoskeleton|small GTPase binding|regulation of Rho protein signal transduction|positive regulation of Rho protein signal transduction|positive regulation of canonical NF-kappaB signal transduction|positive regulation of MAPK cascade|metal ion binding|protein kinase A binding|regulation of small GTPase mediated signal transduction|cardiac muscle cell differentiation|molecular adaptor activity|regulation of sarcomere organization|bone development|adrenergic receptor signaling pathway|adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process","WP35,WP2882,WP2880","G protein signaling pathways|Nuclear receptors meta-pathway|Glucocorticoid receptor pathway","R-HSA-162582,R-HSA-193648,R-HSA-193704,R-HSA-194315,R-HSA-204998,R-HSA-372790,R-HSA-388396,R-HSA-416482,R-HSA-73887,R-HSA-8980692,R-HSA-9012999,R-HSA-9013026,R-HSA-9013106,R-HSA-9716542","Signal Transduction|NRAGE signals death through JNK|p75 NTR receptor-mediated signalling|Signaling by Rho GTPases|Cell death signalling via NRAGE, NRIF and NADE|Signaling by GPCR|GPCR downstream signalling|G alpha (12/13) signalling events|Death Receptor Signaling|RHOA GTPase cycle|RHO GTPase cycle|RHOB GTPase cycle|RHOC GTPase cycle|Signaling by Rho GTPases, Miro GTPases and RHOBTB3"]
["AKAP14",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.0257678601547077,0,0,158798,"A-kinase anchoring protein 14","protein_coding",null,null,"GO:0005515,GO:0005930,GO:0005952,GO:0008150,GO:0034237","protein binding|axoneme|cAMP-dependent protein kinase complex|biological_process|protein kinase A regulatory subunit binding"]
["AKAP17A",0.471881229500973,0.272508385133624,0.316442134356359,0.0888960213022227,0.510506310366946,0.261124593298686,0.196545056129129,0.305729191291466,0.0847586696687033,0.0811575190510943,0.602268806882634,0.508662561120494,0.51286270310093,0.232974079418972,0.0940386222358819,0.127832881511206,0.599512609816647,0.194917447408762,0.13239438989659,0.267400766504893,0.174973035453688,0.344415027340661,0.158056472961701,0.107021348968355,0.183791931762493,0.112093010913695,0.0815412141136098,0.118827577012174,8227,"A-kinase anchoring protein 17A","protein_coding",null,null,"GO:0003723,GO:0005515,GO:0005634,GO:0005681,GO:0005829,GO:0006355,GO:0006397,GO:0007165,GO:0008380,GO:0016607,GO:0042113,GO:0043484,GO:0051018","RNA binding|protein binding|nucleus|spliceosomal complex|cytosol|regulation of DNA-templated transcription|mRNA processing|signal transduction|RNA splicing|nuclear speck|B cell activation|regulation of RNA splicing|protein kinase A binding"]
["AKAP3",0.0808524752106872,0.0922849420278555,0.166995834821025,0.0775422294120659,0.110607889467722,0.151849189064459,0.0754346292210062,0.142710633221559,0.130122607928101,0.0311485187095921,0.0532259550426342,0.048806584673799,0.0615119896228208,0.123332698435975,0.00751923496632139,0.00766604281558095,0.178789941846007,0.157100890215635,0.0896706983194594,0.241023310006396,0.160256769765274,0.0845385834258068,0.167620304314308,0.142183178355771,0.0961908256053144,0.0614595152820143,0.164302856116922,0.0988138861268805,10566,"A-kinase anchoring protein 3","protein_coding",null,null,"GO:0001669,GO:0001835,GO:0005515,GO:0005634,GO:0005737,GO:0007178,GO:0007338,GO:0007340,GO:0008104,GO:0035686,GO:0051018,GO:0097225,GO:0097228","acrosomal vesicle|blastocyst hatching|protein binding|nucleus|cytoplasm|transmembrane receptor protein serine/threonine kinase signaling pathway|single fertilization|acrosome reaction|protein localization|sperm fibrous sheath|protein kinase A binding|sperm midpiece|sperm principal piece","WP35","G protein signaling pathways"]
["AKAP5",0.120507205460467,0.118574840727944,0.0702226413615998,0.083691099892961,0.138057080297993,0.0507279755852612,0.046523641835579,0.0325983420626333,0.167191604297938,0.132072696372234,0.105514193684684,0.129601658506136,0.150167199577894,0.103003811769925,0.0695613270847663,0.114259136067097,0.24770149864347,0.14225998968795,0.0998537435527981,0.115882284426314,0.180416651899267,0.221193319224909,0.205115760672958,0.272002072647479,0.230707721902967,0.102658328632382,0.0965069871248113,0.136730174812888,9495,"A-kinase anchoring protein 5","protein_coding",null,null,"GO:0005515,GO:0005516,GO:0005829,GO:0005886,GO:0007165,GO:0007193,GO:0007194,GO:0007268,GO:0008179,GO:0008287,GO:0009898,GO:0010738,GO:0014069,GO:0017124,GO:0030346,GO:0031698,GO:0032590,GO:0034237,GO:0035254,GO:0043197,GO:0045121,GO:0045762,GO:0050811,GO:0051018,GO:0060076,GO:0060090,GO:0070886,GO:0097110,GO:0098837,GO:1900273,GO:1903078,GO:1905665,GO:1905751","protein binding|calmodulin binding|cytosol|plasma membrane|signal transduction|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway|negative regulation of adenylate cyclase activity|chemical synaptic transmission|adenylate cyclase binding|protein serine/threonine phosphatase complex|cytoplasmic side of plasma membrane|regulation of protein kinase A signaling|postsynaptic density|SH3 domain binding|protein phosphatase 2B binding|beta-2 adrenergic receptor binding|dendrite membrane|protein kinase A regulatory subunit binding|glutamate receptor binding|dendritic spine|membrane raft|positive regulation of adenylate cyclase activity|GABA receptor binding|protein kinase A binding|excitatory synapse|molecular adaptor activity|positive regulation of calcineurin-NFAT signaling cascade|scaffold protein binding|postsynaptic recycling endosome|positive regulation of long-term synaptic potentiation|positive regulation of protein localization to plasma membrane|positive regulation of calcium ion import across plasma membrane|positive regulation of endosome to plasma membrane protein transport","WP35,WP4549","G protein signaling pathways|Fragile X syndrome","R-HSA-112314,R-HSA-112315,R-HSA-112316,R-HSA-1266738,R-HSA-1266738,R-HSA-1430728,R-HSA-163685,R-HSA-376176,R-HSA-376176,R-HSA-381676,R-HSA-399719,R-HSA-399721,R-HSA-422356,R-HSA-422475,R-HSA-422475,R-HSA-9010642,R-HSA-9010642,R-HSA-9675108,R-HSA-9675108","Neurotransmitter receptors and postsynaptic signal transmission|Transmission across Chemical Synapses|Neuronal System|Developmental Biology|Developmental Biology|Metabolism|Integration of energy metabolism|Signaling by ROBO receptors|Signaling by ROBO receptors|Glucagon-like Peptide-1 (GLP1) regulates insulin secretion|Trafficking of AMPA receptors|Glutamate binding, activation of AMPA receptors and synaptic plasticity|Regulation of insulin secretion|Axon guidance|Axon guidance|ROBO receptors bind AKAP5|ROBO receptors bind AKAP5|Nervous system development|Nervous system development"]
["AKAP6",0.040106181368937,0.0589554321940351,0.0479221509105633,0.0338018394631875,0.0724422546457834,0.0353792179589002,0.0249458033548348,0.0440950262822993,0.0696805685455382,0.0456505556101604,0.042289368556932,0.0599138601729776,0.0889947866996805,0.039395010606144,0.0576431739523666,0.0668348977157132,0.132037637258298,0.0742176741951336,0.137035532010983,0.116869559260206,0.11126866509629,0.10050451853153,0.145176644434394,0.1163605706606,0.128925919540083,0.0635134767654585,0.112901862124193,0.0696961062536179,9472,"A-kinase anchoring protein 6","protein_coding",null,null,"GO:0001508,GO:0005515,GO:0005635,GO:0005737,GO:0005901,GO:0006605,GO:0008179,GO:0010738,GO:0010880,GO:0014701,GO:0014704,GO:0016529,GO:0019933,GO:0030307,GO:0030315,GO:0031965,GO:0034237,GO:0034704,GO:0043495,GO:0044325,GO:0048471,GO:0051018,GO:0051281,GO:0060090,GO:0060306,GO:0060316,GO:0061051,GO:0070886,GO:0071320,GO:0071345,GO:1901381,GO:1902261","action potential|protein binding|nuclear envelope|cytoplasm|caveola|protein targeting|adenylate cyclase binding|regulation of protein kinase A signaling|regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|junctional sarcoplasmic reticulum membrane|intercalated disc|sarcoplasmic reticulum|cAMP-mediated signaling|positive regulation of cell growth|T-tubule|nuclear membrane|protein kinase A regulatory subunit binding|calcium channel complex|protein-membrane adaptor activity|transmembrane transporter binding|perinuclear region of cytoplasm|protein kinase A binding|positive regulation of release of sequestered calcium ion into cytosol|molecular adaptor activity|regulation of membrane repolarization|positive regulation of ryanodine-sensitive calcium-release channel activity|positive regulation of cell growth involved in cardiac muscle cell development|positive regulation of calcineurin-NFAT signaling cascade|cellular response to cAMP|cellular response to cytokine stimulus|positive regulation of potassium ion transmembrane transport|positive regulation of delayed rectifier potassium channel activity","WP35","G protein signaling pathways"]
["AKAP7",0.909637459669014,0.923194545735782,1.18415492398596,1.17368641392268,0.751406944954447,1.10517102349598,1.23802804369215,0.708072676202091,0.679154457034374,0.51030419358537,0.820184681680255,0.86327973138365,0.780335065781762,0.692888312867009,1.08579113151003,0.653524482837118,0.892593508819593,1.16269935656182,1.26105951013726,1.36619681299458,1.07984196984131,1.09194723350625,1.62938337345239,1.23683784128929,0.915781612395189,1.23410524948285,1.12071725440095,0.872796717512208,9465,"A-kinase anchoring protein 7","protein_coding",null,null,"GO:0000166,GO:0005515,GO:0005634,GO:0005829,GO:0008150,GO:0010738,GO:0019901,GO:0032991,GO:0034237,GO:0050804,GO:0051018,GO:0098686","nucleotide binding|protein binding|nucleus|cytosol|biological_process|regulation of protein kinase A signaling|protein kinase binding|protein-containing complex|protein kinase A regulatory subunit binding|modulation of chemical synaptic transmission|protein kinase A binding|hippocampal mossy fiber to CA3 synapse","WP35","G protein signaling pathways"]
["AKAP8",9.31147844142367,8.75881882434128,8.30692333240526,9.00078885918527,7.84105385894675,7.97730288913708,8.53655724299062,7.82537543594571,8.16758129970753,8.0543312746614,7.78161180573612,8.16935667330152,7.86190361884013,7.72736563228626,8.24237405188191,7.64316809682756,7.91999461472611,8.23448301506534,7.6066075277974,7.4122532932119,6.6574408044063,7.62044609907944,7.44982905272636,7.45154083907463,6.3294175650097,6.84883708974184,7.72230895457408,6.77629523391917,10270,"A-kinase anchoring protein 8","protein_coding",null,null,"GO:0000278,GO:0000793,GO:0001939,GO:0003690,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0007076,GO:0007165,GO:0008270,GO:0015031,GO:0016020,GO:0016363,GO:0032720,GO:0034237,GO:0042826,GO:0044839,GO:0045087,GO:0051059,GO:0071222,GO:0071380","mitotic cell cycle|condensed chromosome|female pronucleus|double-stranded DNA binding|RNA binding|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|mitotic chromosome condensation|signal transduction|zinc ion binding|protein transport|membrane|nuclear matrix|negative regulation of tumor necrosis factor production|protein kinase A regulatory subunit binding|histone deacetylase binding|cell cycle G2/M phase transition|innate immune response|NF-kappaB binding|cellular response to lipopolysaccharide|cellular response to prostaglandin E stimulus","WP35","G protein signaling pathways"]
["AKAP8L",20.6776742468611,22.9006401152524,27.0003070953548,28.4527665192697,20.6870363016689,23.9854709238509,24.6415819818715,23.1894553755192,21.8167021029713,30.5475456651435,31.6335543347164,25.9455929391452,20.1207331339901,27.6287649738961,24.972616848831102,24.4393223612035,20.0923548585722,26.2859403701786,25.7407622032052,23.3020578824017,20.5696273492752,22.4785866877771,19.6834512895975,19.5425008302859,20.4360217264493,23.5055213951575,20.5868413896572,25.220007642172,26993,"A-kinase anchoring protein 8 like","protein_coding",null,null,"GO:0000785,GO:0003677,GO:0003723,GO:0005515,GO:0005521,GO:0005634,GO:0005654,GO:0005737,GO:0006397,GO:0007076,GO:0008380,GO:0010793,GO:0016363,GO:0016605,GO:0016607,GO:0017151,GO:0034237,GO:0042826,GO:0044839,GO:0045944,GO:0046872,GO:0051081,GO:1990904","chromatin|DNA binding|RNA binding|protein binding|lamin binding|nucleus|nucleoplasm|cytoplasm|mRNA processing|mitotic chromosome condensation|RNA splicing|regulation of mRNA export from nucleus|nuclear matrix|PML body|nuclear speck|DEAD/H-box RNA helicase binding|protein kinase A regulatory subunit binding|histone deacetylase binding|cell cycle G2/M phase transition|positive regulation of transcription by RNA polymerase II|metal ion binding|nuclear membrane disassembly|ribonucleoprotein complex",null,null,"R-HSA-212165,R-HSA-74160,R-HSA-9772755","Epigenetic regulation of gene expression|Gene expression (Transcription)|Formation of WDR5-containing histone-modifying complexes"]
["AKAP9",3.26803360547452,3.28947907057792,2.89706066066314,2.14580486073844,3.76320819622714,2.88631626247088,2.49742168672566,2.21583636835891,3.33811576067624,2.46303407984933,2.30409539843646,2.56269825051299,3.9339407783865,2.58867000977057,3.4309286957258,3.65726040361412,2.79939251229683,2.32498843114982,2.02856183984095,2.63052458480639,2.55898258509281,2.08632146747565,3.17829436457886,2.98704884166518,3.06535732361549,1.89891690113876,2.65885913572739,1.84263640781373,10142,"A-kinase anchoring protein 9","protein_coding",null,null,"GO:0003677,GO:0005102,GO:0005515,GO:0005794,GO:0005795,GO:0005801,GO:0005813,GO:0005829,GO:0005856,GO:0007020,GO:0007165,GO:0007268,GO:0008076,GO:0015459,GO:0031116,GO:0031503,GO:0033138,GO:0034237,GO:0034705,GO:0043025,GO:0043231,GO:0044307,GO:0044325,GO:0051602,GO:0051661,GO:0060090,GO:0060306,GO:0060307,GO:0071320,GO:0086091,GO:0097060,GO:0098909,GO:0098978,GO:0099147,GO:1901018,GO:1903358","DNA binding|signaling receptor binding|protein binding|Golgi apparatus|Golgi stack|cis-Golgi network|centrosome|cytosol|cytoskeleton|microtubule nucleation|signal transduction|chemical synaptic transmission|voltage-gated potassium channel complex|potassium channel regulator activity|positive regulation of microtubule polymerization|protein-containing complex localization|positive regulation of peptidyl-serine phosphorylation|protein kinase A regulatory subunit binding|potassium channel complex|neuronal cell body|intracellular membrane-bounded organelle|dendritic branch|transmembrane transporter binding|response to electrical stimulus|maintenance of centrosome location|molecular adaptor activity|regulation of membrane repolarization|regulation of ventricular cardiac muscle cell membrane repolarization|cellular response to cAMP|regulation of heart rate by cardiac conduction|synaptic membrane|regulation of cardiac muscle cell action potential involved in regulation of contraction|glutamatergic synapse|extrinsic component of postsynaptic density membrane|positive regulation of potassium ion transmembrane transporter activity|regulation of Golgi organization","WP35,WP4008","G protein signaling pathways|NO/cGMP/PKG mediated neuroprotection","R-HSA-1640170,R-HSA-1643685,R-HSA-1852241,R-HSA-2565942,R-HSA-380259,R-HSA-380270,R-HSA-380284,R-HSA-380287,R-HSA-380320,R-HSA-397014,R-HSA-453274,R-HSA-5576890,R-HSA-5576891,R-HSA-5576893,R-HSA-5617833,R-HSA-5620912,R-HSA-5663202,R-HSA-6802952,R-HSA-6802957,R-HSA-68877,R-HSA-68886,R-HSA-69275,R-HSA-69278,R-HSA-8854518","Cell Cycle|Disease|Organelle biogenesis and maintenance|Regulation of PLK1 Activity at G2/M Transition|Loss of Nlp from mitotic centrosomes|Recruitment of mitotic centrosome proteins and complexes|Loss of proteins required for interphase microtubule organization from the centrosome|Centrosome maturation|Recruitment of NuMA to mitotic centrosomes|Muscle contraction|Mitotic G2-G2/M phases|Phase 3 - rapid repolarisation|Cardiac conduction|Phase 2 - plateau phase|Cilium Assembly|Anchoring of the basal body to the plasma membrane|Diseases of signal transduction by growth factor receptors and second messengers|Signaling by BRAF and RAF1 fusions|Oncogenic MAPK signaling|Mitotic Prometaphase|M Phase|G2/M Transition|Cell Cycle, Mitotic|AURKA Activation by TPX2"]
["AKIP1",10.1675525178195,8.31708525636028,9.9503983050031,9.66546340836833,9.93530432271607,9.33397812203665,9.71390431180532,11.390036791012,7.67447553546864,7.11338552587692,8.19271759781466,7.67614372348091,6.74527039857296,7.38258219276998,7.18638289343082,6.51689975900396,11.0814907623044,9.71625009427246,10.6750702484371,9.62871865065113,9.48917928285797,10.3140967780476,8.60825665134845,9.71091181740445,10.3303402811245,11.1681202703715,10.1301868636972,10.6445413610104,56672,"A-kinase interacting protein 1","protein_coding",null,null,"GO:0005515,GO:0005654,GO:0034446,GO:1901222","protein binding|nucleoplasm|substrate adhesion-dependent cell spreading|regulation of non-canonical NF-kappaB signal transduction"]
["AKIRIN1",23.2758093604908,21.7385340565124,17.7284027551961,17.4658794580895,21.4506354679398,19.8419041795069,17.0379381328639,17.2582708289309,20.3861596432305,16.6031164814364,16.4478158318227,19.0184383665123,20.4852088387526,17.9743184333337,19.1655732407758,18.6935199199742,17.8467030275961,17.7041081013286,17.4987741901067,19.7112685604761,19.4606136751896,18.5975562791984,19.5528811791951,19.1735649896834,18.9699902523552,16.4466051589521,17.2056421064863,15.5747470228158,79647,"akirin 1","protein_coding",null,null,"GO:0000785,GO:0003712,GO:0005515,GO:0005634,GO:0005654,GO:0010592,GO:0010759,GO:0014839,GO:0031965,GO:0045663,GO:0045944,GO:1902723,GO:1902725","chromatin|transcription coregulator activity|protein binding|nucleus|nucleoplasm|positive regulation of lamellipodium assembly|positive regulation of macrophage chemotaxis|myoblast migration involved in skeletal muscle regeneration|nuclear membrane|positive regulation of myoblast differentiation|positive regulation of transcription by RNA polymerase II|negative regulation of skeletal muscle satellite cell proliferation|negative regulation of satellite cell differentiation"]
["AKIRIN2",26.5301422863193,31.0974160718055,31.4143177248541,30.2521488904993,28.0474750769219,29.5677012720703,29.4166438085718,30.6390923941429,26.5142981457037,25.1415646222813,29.2241661175197,26.7486827346486,28.660552262913,30.2896058845448,28.5692975995777,28.9520345133645,21.9295730008711,25.1518927269725,22.3932804963213,21.4147396240552,22.9225319980831,23.7193853078772,19.7414647291418,20.882457222234,22.2051385326625,22.1585676584751,19.6531081057795,23.4059315512817,55122,"akirin 2","protein_coding",null,null,"GO:0000122,GO:0000785,GO:0002250,GO:0002821,GO:0003712,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006606,GO:0008284,GO:0009792,GO:0010629,GO:0016020,GO:0017053,GO:0019899,GO:0021987,GO:0030674,GO:0031144,GO:0032496,GO:0032755,GO:0042742,GO:0042802,GO:0045087,GO:0045089,GO:0045944,GO:0050871,GO:0051147,GO:0071630","negative regulation of transcription by RNA polymerase II|chromatin|adaptive immune response|positive regulation of adaptive immune response|transcription coregulator activity|protein binding|nucleus|nucleoplasm|cytoplasm|protein import into nucleus|positive regulation of cell population proliferation|embryo development ending in birth or egg hatching|negative regulation of gene expression|membrane|transcription repressor complex|enzyme binding|cerebral cortex development|protein-macromolecule adaptor activity|proteasome localization|response to lipopolysaccharide|positive regulation of interleukin-6 production|defense response to bacterium|identical protein binding|innate immune response|positive regulation of innate immune response|positive regulation of transcription by RNA polymerase II|positive regulation of B cell activation|regulation of muscle cell differentiation|nuclear protein quality control by the ubiquitin-proteasome system"]
["AKNA",2.30374165926337,3.59409823586818,4.36572275545995,3.12709245263413,2.88238565432201,3.8659522962727,4.02296135156354,3.55888742012944,2.00767188217238,2.99361701914243,2.66518298382307,2.14913573865805,1.97639079612952,2.826765301674,2.60440084762837,2.71014632249873,1.36527401433906,1.48871626827769,1.27862684755325,1.5032574959448,1.56176461906808,1.37006787215583,1.20935009648013,1.3843545308409,1.29304856224239,1.70253139954129,1.16477374926552,1.74752389408234,80709,"AT-hook transcription factor","protein_coding",null,null,"GO:0001650,GO:0001837,GO:0003677,GO:0005515,GO:0005654,GO:0005813,GO:0005814,GO:0005829,GO:0005874,GO:0016020,GO:0021849,GO:0043231,GO:0045944,GO:0050727,GO:0060232,GO:0060234","fibrillar center|epithelial to mesenchymal transition|DNA binding|protein binding|nucleoplasm|centrosome|centriole|cytosol|microtubule|membrane|neuroblast division in subventricular zone|intracellular membrane-bounded organelle|positive regulation of transcription by RNA polymerase II|regulation of inflammatory response|delamination|neuroblast delamination"]
["AKNAD1",0.0176762067116348,0.0168130052852934,0.0248925833067048,0.0339050220144036,0.0604535579484242,0.00829942944821159,0.00824587061714212,0.00866661659673371,0.0800094051944799,0,0.0748055272603879,0.0622430641047608,0.050429747557988,0.0589823466413686,0.0328775467248728,0.00837986450726127,0.00849730101375035,0.0327103430431805,0.024505090835826,0.00849890762095533,0.0166837180451967,0.0168018859696953,0.00872515370154415,0.00863458500251626,0.0087623008898393,0.0503867272008776,0.0684197623473935,0.033235359026181,254268,"AKNA domain containing 1","protein_coding"]
["AKR1A1",35.2202888060983,34.181041671108,44.2800559015011,41.0013409788437,36.63024867563,38.4019112268703,46.1028606881302,43.526191855372,37.0036474740406,41.3230386139776,42.5450525616523,42.446015126091,38.2258230291135,45.9893463240229,44.8772278114351,42.3122242040314,45.1495656519486,42.3629440358612,49.0868568926617,40.6357378286385,45.127769957714,44.3946292038406,42.609028883903,46.2951843998691,45.2906273648928,47.8588975029153,50.3563179786083,49.1300854466745,10327,"aldo-keto reductase family 1 member A1","protein_coding","hsa00010,hsa00040,hsa00053,hsa00620,hsa00561,hsa05208","Glycolysis / Gluconeogenesis|Pentose and glucuronate interconversions|Ascorbate and aldarate metabolism|Pyruvate metabolism|Glycerolipid metabolism|Chemical carcinogenesis - reactive oxygen species","GO:0004032,GO:0004033,GO:0004745,GO:0005515,GO:0005615,GO:0005829,GO:0006629,GO:0016324,GO:0016657,GO:0019640,GO:0019853,GO:0042840,GO:0043066,GO:0044597,GO:0044598,GO:0045202,GO:0046185,GO:0047655,GO:0047939,GO:0047941,GO:0047956,GO:0070062,GO:0110095,GO:1901687,GO:1990002","alditol:NADP+ 1-oxidoreductase activity|aldo-keto reductase (NADP) activity|NAD-retinol dehydrogenase activity|protein binding|extracellular space|cytosol|lipid metabolic process|apical plasma membrane|oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor|glucuronate catabolic process to xylulose 5-phosphate|L-ascorbic acid biosynthetic process|D-glucuronate catabolic process|negative regulation of apoptotic process|daunorubicin metabolic process|doxorubicin metabolic process|synapse|aldehyde catabolic process|allyl-alcohol dehydrogenase activity|L-glucuronate reductase activity|glucuronolactone reductase activity|glycerol dehydrogenase [NADP+] activity|extracellular exosome|cellular detoxification of aldehyde|glutathione derivative biosynthetic process|methylglyoxal reductase (NADPH-dependent, acetol producing)","WP696,WP702","Benzo(a)pyrene metabolism|Metapathway biotransformation Phase I and II","R-HSA-1430728,R-HSA-156580,R-HSA-156590,R-HSA-211859,R-HSA-5661270,R-HSA-71387","Metabolism|Phase II - Conjugation of compounds|Glutathione conjugation|Biological oxidations|Formation of xylulose-5-phosphate|Metabolism of carbohydrates"]
["AKR1B1",95.3064190358074,88.8847546082514,98.7966499119502,105.989712809652,100.882242012766,101.50559786953,109.450563287252,118.367902694899,58.3971896734283,60.3549661250002,70.5682436527587,66.2569049765893,57.6296136709816,65.2101716778941,65.2593209197673,60.83059557779,74.5885761049625,77.4830886654932,79.0114143092276,69.289030671033,71.539480325322,71.4303035872876,73.7162713685019,76.0444572646776,71.1455120096317,78.768012948217,82.7386533143931,83.4848102377376,231,"aldo-keto reductase family 1 member B","protein_coding","hsa00040,hsa00051,hsa00052,hsa00561,hsa00790","Pentose and glucuronate interconversions|Fructose and mannose metabolism|Galactose metabolism|Glycerolipid metabolism|Folate biosynthesis","GO:0001523,GO:0001758,GO:0002070,GO:0003091,GO:0004032,GO:0005515,GO:0005615,GO:0005654,GO:0005829,GO:0005975,GO:0006693,GO:0006700,GO:0009055,GO:0019853,GO:0022900,GO:0035809,GO:0036130,GO:0042572,GO:0043066,GO:0043795,GO:0044597,GO:0044598,GO:0046370,GO:0047655,GO:0047939,GO:0047956,GO:0052650,GO:0070062,GO:0071475,GO:0072205","retinoid metabolic process|retinal dehydrogenase activity|epithelial cell maturation|renal water homeostasis|alditol:NADP+ 1-oxidoreductase activity|protein binding|extracellular space|nucleoplasm|cytosol|carbohydrate metabolic process|prostaglandin metabolic process|C21-steroid hormone biosynthetic process|electron transfer activity|L-ascorbic acid biosynthetic process|electron transport chain|regulation of urine volume|prostaglandin H2 endoperoxidase reductase activity|retinol metabolic process|negative regulation of apoptotic process|glyceraldehyde oxidoreductase activity|daunorubicin metabolic process|doxorubicin metabolic process|fructose biosynthetic process|allyl-alcohol dehydrogenase activity|L-glucuronate reductase activity|glycerol dehydrogenase [NADP+] activity|NADP-retinol dehydrogenase activity|extracellular exosome|cellular hyperosmotic salinity response|metanephric collecting duct development","WP98,WP702,WP690,WP4719,WP5173","Prostaglandin synthesis and regulation|Metapathway biotransformation Phase I and II|Polyol pathway|Eicosanoid metabolism via cyclooxygenases (COX)|Disorders of galactose metabolism ","R-HSA-1430728,R-HSA-196071,R-HSA-196108,R-HSA-556833,R-HSA-5652084,R-HSA-5652227,R-HSA-71387,R-HSA-8957322","Metabolism|Metabolism of steroid hormones|Pregnenolone biosynthesis|Metabolism of lipids|Fructose metabolism|Fructose biosynthesis|Metabolism of carbohydrates|Metabolism of steroids"]
["AKR1B10",0.0306204641066752,0.0194167611208425,0.0862427630656376,0.0685225501711016,0.11968411429179,0.0766778033079754,0.0380914886516977,0.100087772131911,0,0,0.0383957016524352,0.0102689103434586,0.0194131932414317,0,0.0189845735537414,0.00967761709471674,0,0.00944401233261083,0,0.0294452876682095,0,0,0.0100763797007609,0,0.010119279709962,0,0.0197539071525511,0,57016,"aldo-keto reductase family 1 member B10","protein_coding","hsa00040,hsa00051,hsa00052,hsa00561,hsa00790","Pentose and glucuronate interconversions|Fructose and mannose metabolism|Galactose metabolism|Glycerolipid metabolism|Folate biosynthesis","GO:0001523,GO:0001758,GO:0004032,GO:0004033,GO:0005515,GO:0005576,GO:0005739,GO:0005764,GO:0005829,GO:0008106,GO:0016488,GO:0042572,GO:0044597,GO:0044598,GO:0045550,GO:0047655,GO:0047718,GO:0052650,GO:0110095","retinoid metabolic process|retinal dehydrogenase activity|alditol:NADP+ 1-oxidoreductase activity|aldo-keto reductase (NADP) activity|protein binding|extracellular region|mitochondrion|lysosome|cytosol|alcohol dehydrogenase (NADP+) activity|farnesol catabolic process|retinol metabolic process|daunorubicin metabolic process|doxorubicin metabolic process|geranylgeranyl reductase activity|allyl-alcohol dehydrogenase activity|indanol dehydrogenase activity|NADP-retinol dehydrogenase activity|cellular detoxification of aldehyde","WP702","Metapathway biotransformation Phase I and II","R-HSA-1430728,R-HSA-196854,R-HSA-2187338,R-HSA-6806667,R-HSA-9709957,R-HSA-975634","Metabolism|Metabolism of vitamins and cofactors|Visual phototransduction|Metabolism of fat-soluble vitamins|Sensory Perception|Retinoid metabolism and transport"]
["AKR1B15",0,0,0.00745872670060415,0,0,0,0,0.0155810083230402,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,441282,"aldo-keto reductase family 1 member B15","protein_coding","hsa00040,hsa00051,hsa00052,hsa00561,hsa00790","Pentose and glucuronate interconversions|Fructose and mannose metabolism|Galactose metabolism|Glycerolipid metabolism|Folate biosynthesis","GO:0004032,GO:0004303,GO:0005739,GO:0005759,GO:0005829,GO:0006703,GO:0042572,GO:0047045,GO:0047655,GO:0047886,GO:0052650","alditol:NADP+ 1-oxidoreductase activity|estradiol 17-beta-dehydrogenase [NAD(P)] activity|mitochondrion|mitochondrial matrix|cytosol|estrogen biosynthetic process|retinol metabolic process|testosterone 17-beta-dehydrogenase (NADP+) activity|allyl-alcohol dehydrogenase activity|farnesol dehydrogenase activity|NADP-retinol dehydrogenase activity",null,null,"R-HSA-1430728,R-HSA-193144,R-HSA-196071,R-HSA-556833,R-HSA-8957322","Metabolism|Estrogen biosynthesis|Metabolism of steroid hormones|Metabolism of lipids|Metabolism of steroids"]
["AKR1C1",1.94457184640604,2.05729976410485,1.77148349998145,2.17314971836933,1.84781900940801,1.98080223541605,2.03720768036225,2.32699251675711,0.62160243986745,0.646775687932836,0.670286081120513,0.530549381596441,0.49366121520543,0.707000028517093,0.758625648294004,0.652343571262957,0.63375865729943,0.76620341596446,0.731070415887703,0.820080288321893,0.559948721186795,0.834123889669311,0.646685509332697,0.503123266423555,0.555494789715014,0.837725224005625,0.996677150960714,0.708784794454491,1645,"aldo-keto reductase family 1 member C1","protein_coding","hsa00140,hsa00980,hsa05208","Steroid hormone biosynthesis|Metabolism of xenobiotics by cytochrome P450|Chemical carcinogenesis - reactive oxygen species","GO:0001523,GO:0004032,GO:0004033,GO:0004303,GO:0005515,GO:0005829,GO:0006693,GO:0006805,GO:0007586,GO:0008206,GO:0015721,GO:0016655,GO:0018636,GO:0030283,GO:0030299,GO:0030855,GO:0031406,GO:0032052,GO:0033703,GO:0033764,GO:0035410,GO:0042448,GO:0042574,GO:0042632,GO:0044597,GO:0044598,GO:0046683,GO:0047006,GO:0047023,GO:0047024,GO:0047042,GO:0047044,GO:0047045,GO:0047086,GO:0047115,GO:0047718,GO:0070062,GO:0071395,GO:2000379","retinoid metabolic process|alditol:NADP+ 1-oxidoreductase activity|aldo-keto reductase (NADP) activity|estradiol 17-beta-dehydrogenase [NAD(P)] activity|protein binding|cytosol|prostaglandin metabolic process|xenobiotic metabolic process|digestion|bile acid metabolic process|bile acid and bile salt transport|oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor|phenanthrene 9,10-monooxygenase activity|testosterone dehydrogenase [NAD(P)] activity|intestinal cholesterol absorption|epithelial cell differentiation|carboxylic acid binding|bile acid binding|3beta-hydroxy-5beta-steroid dehydrogenase activity|steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|dihydrotestosterone 17-beta-dehydrogenase activity|progesterone metabolic process|retinal metabolic process|cholesterol homeostasis|daunorubicin metabolic process|doxorubicin metabolic process|response to organophosphorus|17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity|androsterone dehydrogenase activity|5alpha-androstane-3beta,17beta-diol dehydrogenase activity|androsterone dehydrogenase (B-specific) activity|androstan-3-alpha,17-beta-diol dehydrogenase activity|testosterone 17-beta-dehydrogenase (NADP+) activity|ketosteroid monooxygenase activity|trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity|indanol dehydrogenase activity|extracellular exosome|cellular response to jasmonic acid stimulus|positive regulation of reactive oxygen species metabolic process","WP98,WP696,WP5280,WP702,WP5279,WP4313,WP5277","Prostaglandin synthesis and regulation|Benzo(a)pyrene metabolism|Glucocorticoid biosynthesis|Metapathway biotransformation Phase I and II|Mineralocorticoid biosynthesis|Ferroptosis|Steroid hormone precursor biosynthesis","R-HSA-1430728,R-HSA-192105,R-HSA-193368,R-HSA-193775,R-HSA-193807,R-HSA-194068,R-HSA-196854,R-HSA-2187338,R-HSA-556833,R-HSA-6806667,R-HSA-8957322,R-HSA-9709957,R-HSA-9748784,R-HSA-975634,R-HSA-9757110","Metabolism|Synthesis of bile acids and bile salts|Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol|Synthesis of bile acids and bile salts via 24-hydroxycholesterol|Synthesis of bile acids and bile salts via 27-hydroxycholesterol|Bile acid and bile salt metabolism|Metabolism of vitamins and cofactors|Visual phototransduction|Metabolism of lipids|Metabolism of fat-soluble vitamins|Metabolism of steroids|Sensory Perception|Drug ADME|Retinoid metabolism and transport|Prednisone ADME"]
["AKR1C2",0.35305254006867,0.43531125738663,0.282353418864151,0.307246273347842,0.300267403482437,0.25172050751852,0.189097032949499,0.250034936740595,0.0263054071569422,0.0503755330476741,0.0491889634072672,0.105244500478581,0.12435179080917,0.0436323447140854,0.060803127280416,0.0495922129461982,0.113146210442613,0.127037198151571,0.0120851365590216,0.025148356288056,0.0925636794285411,0.0807900532013609,0.0903623728003724,0.0510996541502296,0.0583374143648044,0.049698283761881,0.0442869853903969,0.0983437739799681,1646,"aldo-keto reductase family 1 member C2","protein_coding","hsa00140,hsa05204,hsa05208","Steroid hormone biosynthesis|Chemical carcinogenesis - DNA adducts|Chemical carcinogenesis - reactive oxygen species","GO:0004032,GO:0004303,GO:0005829,GO:0006693,GO:0007186,GO:0007586,GO:0008202,GO:0008284,GO:0016655,GO:0018636,GO:0030855,GO:0031406,GO:0032052,GO:0042448,GO:0044597,GO:0044598,GO:0047023,GO:0047044,GO:0047086,GO:0047115,GO:0047718,GO:0051897,GO:0071395,GO:0071799","alditol:NADP+ 1-oxidoreductase activity|estradiol 17-beta-dehydrogenase [NAD(P)] activity|cytosol|prostaglandin metabolic process|G protein-coupled receptor signaling pathway|digestion|steroid metabolic process|positive regulation of cell population proliferation|oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor|phenanthrene 9,10-monooxygenase activity|epithelial cell differentiation|carboxylic acid binding|bile acid binding|progesterone metabolic process|daunorubicin metabolic process|doxorubicin metabolic process|androsterone dehydrogenase activity|androstan-3-alpha,17-beta-diol dehydrogenase activity|ketosteroid monooxygenase activity|trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity|indanol dehydrogenase activity|positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction|cellular response to jasmonic acid stimulus|cellular response to prostaglandin D stimulus","WP98,WP696,WP4524,WP5280,WP702,WP5279,WP4313","Prostaglandin synthesis and regulation|Benzo(a)pyrene metabolism|Alternative pathway of fetal androgen synthesis|Glucocorticoid biosynthesis|Metapathway biotransformation Phase I and II|Mineralocorticoid biosynthesis|Ferroptosis","R-HSA-1430728,R-HSA-192105,R-HSA-193368,R-HSA-193775,R-HSA-193807,R-HSA-194068,R-HSA-556833,R-HSA-8957322","Metabolism|Synthesis of bile acids and bile salts|Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol|Synthesis of bile acids and bile salts via 24-hydroxycholesterol|Synthesis of bile acids and bile salts via 27-hydroxycholesterol|Bile acid and bile salt metabolism|Metabolism of lipids|Metabolism of steroids"]
["AKR1C3",2.21021380756015,1.55675166996807,1.58910359268974,2.42829104865743,2.50145699228356,2.08863949709922,1.97075024012703,2.04387333284153,0.140707308910317,0.148201968753967,0.197333383622369,0.365918524983878,0.372487497098441,0.133365080625824,0.390282242517626,0.278531562890547,0.726261275020593,0.789538054382946,0.41371680774548,0.524621204728924,0.79219522632875,0.651541737978976,0.607636547351959,0.874660608454164,0.62409226628461,0.8107983563158,0.798659589673941,0.789059509832788,8644,"aldo-keto reductase family 1 member C3","protein_coding","hsa00140,hsa00590,hsa00790,hsa04913,hsa05208","Steroid hormone biosynthesis|Arachidonic acid metabolism|Folate biosynthesis|Ovarian steroidogenesis|Chemical carcinogenesis - reactive oxygen species","GO:0001523,GO:0001758,GO:0004032,GO:0004033,GO:0004303,GO:0004745,GO:0005634,GO:0005737,GO:0005829,GO:0006693,GO:0007186,GO:0007584,GO:0008202,GO:0008284,GO:0008584,GO:0009267,GO:0016488,GO:0016655,GO:0018636,GO:0019371,GO:0030216,GO:0032052,GO:0035410,GO:0036130,GO:0036131,GO:0042448,GO:0042572,GO:0042574,GO:0043170,GO:0044597,GO:0044598,GO:0045550,GO:0045703,GO:0047017,GO:0047020,GO:0047023,GO:0047024,GO:0047035,GO:0047044,GO:0047045,GO:0047086,GO:0047787,GO:0048385,GO:0051897,GO:0052650,GO:0061370,GO:0070062,GO:0070293,GO:0071277,GO:0071379,GO:0071384,GO:0071395,GO:0071799,GO:1900053,GO:2000224,GO:2000353,GO:2000379","retinoid metabolic process|retinal dehydrogenase activity|alditol:NADP+ 1-oxidoreductase activity|aldo-keto reductase (NADP) activity|estradiol 17-beta-dehydrogenase [NAD(P)] activity|NAD-retinol dehydrogenase activity|nucleus|cytoplasm|cytosol|prostaglandin metabolic process|G protein-coupled receptor signaling pathway|response to nutrient|steroid metabolic process|positive regulation of cell population proliferation|male gonad development|cellular response to starvation|farnesol catabolic process|oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor|phenanthrene 9,10-monooxygenase activity|cyclooxygenase pathway|keratinocyte differentiation|bile acid binding|dihydrotestosterone 17-beta-dehydrogenase activity|prostaglandin H2 endoperoxidase reductase activity|prostaglandin D2 11-ketoreductase activity|progesterone metabolic process|retinol metabolic process|retinal metabolic process|macromolecule metabolic process|daunorubicin metabolic process|doxorubicin metabolic process|geranylgeranyl reductase activity|ketoreductase activity|prostaglandin-F synthase activity|15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity|androsterone dehydrogenase activity|5alpha-androstane-3beta,17beta-diol dehydrogenase activity|testosterone dehydrogenase (NAD+) activity|androstan-3-alpha,17-beta-diol dehydrogenase activity|testosterone 17-beta-dehydrogenase (NADP+) activity|ketosteroid monooxygenase activity|delta4-3-oxosteroid 5beta-reductase activity|regulation of retinoic acid receptor signaling pathway|positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction|NADP-retinol dehydrogenase activity|testosterone biosynthetic process|extracellular exosome|renal absorption|cellular response to calcium ion|cellular response to prostaglandin stimulus|cellular response to corticosteroid stimulus|cellular response to jasmonic acid stimulus|cellular response to prostaglandin D stimulus|negative regulation of retinoic acid biosynthetic process|regulation of testosterone biosynthetic process|positive regulation of endothelial cell apoptotic process|positive regulation of reactive oxygen species metabolic process","WP5320,WP167,WP5276,WP98,WP696,WP5280,WP702,WP5279,WP4313","Male steroid hormones in cardiomyocyte energy metabolism|Eicosanoid synthesis|Estrogen metabolism|Prostaglandin synthesis and regulation|Benzo(a)pyrene metabolism|Glucocorticoid biosynthesis|Metapathway biotransformation Phase I and II|Mineralocorticoid biosynthesis|Ferroptosis","R-HSA-1430728,R-HSA-162582,R-HSA-192105,R-HSA-193368,R-HSA-193775,R-HSA-193807,R-HSA-194068,R-HSA-196854,R-HSA-2142753,R-HSA-2162123,R-HSA-2187338,R-HSA-5362517,R-HSA-5365859,R-HSA-556833,R-HSA-6806667,R-HSA-8957322,R-HSA-8978868,R-HSA-9006931,R-HSA-9709957,R-HSA-975634","Metabolism|Signal Transduction|Synthesis of bile acids and bile salts|Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol|Synthesis of bile acids and bile salts via 24-hydroxycholesterol|Synthesis of bile acids and bile salts via 27-hydroxycholesterol|Bile acid and bile salt metabolism|Metabolism of vitamins and cofactors|Arachidonic acid metabolism|Synthesis of Prostaglandins (PG) and Thromboxanes (TX)|Visual phototransduction|Signaling by Retinoic Acid|RA biosynthesis pathway|Metabolism of lipids|Metabolism of fat-soluble vitamins|Metabolism of steroids|Fatty acid metabolism|Signaling by Nuclear Receptors|Sensory Perception|Retinoid metabolism and transport"]
["AKR1E2",0.727890600411605,0.535413255619876,0.305238487772284,0.488662614766551,0.436241953460919,0.40100213571557,0.556874592623018,0.537704664277997,0.497868305950649,0.392589088916901,0.337705920645455,0.624911719853378,0.263042652653951,0.342350922899753,0.35200577704083,0.460100571505794,0.489875904528092,0.489403849896732,0.461942651429627,0.410640289012495,0.425952891405945,0.525834001049782,0.450315313453232,0.459863541493147,0.370445790095186,0.442641275860095,0.38974938879934,0.524631061135598,83592,"aldo-keto reductase family 1 member E2","protein_coding",null,null,"GO:0004032,GO:0005829,GO:0016491,GO:0050571","alditol:NADP+ 1-oxidoreductase activity|cytosol|oxidoreductase activity|1,5-anhydro-D-fructose reductase activity"]
["AKR7A2",16.8077508511462,18.365913257234,20.5435888934282,18.5577888727176,16.8764121651797,20.4903057701932,21.4624049367711,21.8913970083474,16.7613780654228,21.4815896053503,21.4692593171184,19.3848796603143,17.775250462911,20.1945285350573,18.5984415352811,20.0057666405693,18.3762651190263,19.7799844050298,22.173879158947,17.1623416322819,18.1858259929086,19.0679593456578,19.1433670102378,16.7525455415371,16.5615516417861,22.4641627058844,19.8999231466581,22.1101112918301,8574,"aldo-keto reductase family 7 member A2","protein_coding","hsa00980","Metabolism of xenobiotics by cytochrome P450","GO:0004032,GO:0004033,GO:0005515,GO:0005737,GO:0005739,GO:0005794,GO:0005829,GO:0005975,GO:0006081,GO:0006629,GO:0009055,GO:0019119,GO:0022900,GO:0044597,GO:0044598,GO:0070062","alditol:NADP+ 1-oxidoreductase activity|aldo-keto reductase (NADP) activity|protein binding|cytoplasm|mitochondrion|Golgi apparatus|cytosol|carbohydrate metabolic process|cellular aldehyde metabolic process|lipid metabolic process|electron transfer activity|phenanthrene-9,10-epoxide hydrolase activity|electron transport chain|daunorubicin metabolic process|doxorubicin metabolic process|extracellular exosome","WP4157,WP702,WP699","GABA metabolism (aka GHB)|Metapathway biotransformation Phase I and II|Aflatoxin B1 metabolism","R-HSA-1430728,R-HSA-211859,R-HSA-5423646","Metabolism|Biological oxidations|Aflatoxin activation and detoxification"]
["AKR7A3",0.204578419196041,0.434961453697659,0.282449326954797,0.427029211420251,0.352774269915868,0.192109561111505,0.25823563562166,0.212409487125303,0.338928730337727,0.28975770473711,0.588499832514758,0.290573488040082,0.240329265706036,0.137675630553194,0.302172541606392,0.308072250970074,0.115699857553297,0.311770457130315,0.200197840310543,0.162010426524461,0.124941683128649,0.183020543598467,0.273245326858626,0.141082951380399,0.167031360712561,0.262993222703985,0.163031464968398,0.328087891279655,22977,"aldo-keto reductase family 7 member A3","protein_coding","hsa00980","Metabolism of xenobiotics by cytochrome P450","GO:0004033,GO:0005515,GO:0005737,GO:0005794,GO:0005829,GO:0006081,GO:0009055,GO:0022900,GO:0042802,GO:0070062","aldo-keto reductase (NADP) activity|protein binding|cytoplasm|Golgi apparatus|cytosol|cellular aldehyde metabolic process|electron transfer activity|electron transport chain|identical protein binding|extracellular exosome","WP702,WP699","Metapathway biotransformation Phase I and II|Aflatoxin B1 metabolism","R-HSA-1430728,R-HSA-211859,R-HSA-5423646","Metabolism|Biological oxidations|Aflatoxin activation and detoxification"]
["AKT1",65.9502810774523,63.3787689742211,57.9084145453046,64.0492514780191,59.7216272813082,62.1393210522053,58.651030449941,57.8541942625791,61.827305156221,78.5900004745153,70.1343719242153,66.0959880380213,57.8733435760838,59.8796452618958,58.7135688340019,56.44407352873,71.6392264890501,73.6207800681935,82.2065123830105,72.4540005816783,78.8820137295608,77.6832502186889,71.8680918977911,71.7577987309496,71.8751138755355,79.0188081762757,72.8415178894427,82.463950468059,207,"AKT serine/threonine kinase 1","protein_coding","hsa04010,hsa04012,hsa04014,hsa04015,hsa04370,hsa04371,hsa04630,hsa04668,hsa04066,hsa04068,hsa04072,hsa04071,hsa04024,hsa04022,hsa04151,hsa04152,hsa04150,hsa04140,hsa04210,hsa04218,hsa04510,hsa04550,hsa04810,hsa04611,hsa04613,hsa04620,hsa04625,hsa04660,hsa04662,hsa04664,hsa04666,hsa04062,hsa04910,hsa04922,hsa04923,hsa04920,hsa04929,hsa04915,hsa04914,hsa04917,hsa04926,hsa04935,hsa04919,hsa04261,hsa04973,hsa04725,hsa04728,hsa04722,hsa04380,hsa04211,hsa04213,hsa05200,hsa05205,hsa05207,hsa05208,hsa05230,hsa05231,hsa05235,hsa05210,hsa05212,hsa05225,hsa05226,hsa05214,hsa05221,hsa05220,hsa05218,hsa05211,hsa05215,hsa05213,hsa05224,hsa05222,hsa05223,hsa05166,hsa05170,hsa05161,hsa05160,hsa05164,hsa05162,hsa05168,hsa05163,hsa05167,hsa05169,hsa05165,hsa05132,hsa05131,hsa05135,hsa05152,hsa05145,hsa05142,hsa05010,hsa05017,hsa05417,hsa05418,hsa05415,hsa04936,hsa04932,hsa04931,hsa04933,hsa01521,hsa01524,hsa01522","MAPK signaling pathway|ErbB signaling pathway|Ras signaling pathway|Rap1 signaling pathway|VEGF signaling pathway|Apelin signaling pathway|JAK-STAT signaling pathway|TNF signaling pathway|HIF-1 signaling pathway|FoxO signaling pathway|Phospholipase D signaling pathway|Sphingolipid signaling pathway|cAMP signaling pathway|cGMP-PKG signaling pathway|PI3K-Akt signaling pathway|AMPK signaling pathway|mTOR signaling pathway|Autophagy - animal|Apoptosis|Cellular senescence|Focal adhesion|Signaling pathways regulating pluripotency of stem cells|Regulation of actin cytoskeleton|Platelet activation|Neutrophil extracellular trap formation|Toll-like receptor signaling pathway|C-type lectin receptor signaling pathway|T cell receptor signaling pathway|B cell receptor signaling pathway|Fc epsilon RI signaling pathway|Fc gamma R-mediated phagocytosis|Chemokine signaling pathway|Insulin signaling pathway|Glucagon signaling pathway|Regulation of lipolysis in adipocytes|Adipocytokine signaling pathway|GnRH secretion|Estrogen signaling pathway|Progesterone-mediated oocyte maturation|Prolactin signaling pathway|Relaxin signaling pathway|Growth hormone synthesis, secretion and action|Thyroid hormone signaling pathway|Adrenergic signaling in cardiomyocytes|Carbohydrate digestion and absorption|Cholinergic synapse|Dopaminergic synapse|Neurotrophin signaling pathway|Osteoclast differentiation|Longevity regulating pathway|Longevity regulating pathway - multiple species|Pathways in cancer|Proteoglycans in cancer|Chemical carcinogenesis - receptor activation|Chemical carcinogenesis - reactive oxygen species|Central carbon metabolism in cancer|Choline metabolism in cancer|PD-L1 expression and PD-1 checkpoint pathway in cancer|Colorectal cancer|Pancreatic cancer|Hepatocellular carcinoma|Gastric cancer|Glioma|Acute myeloid leukemia|Chronic myeloid leukemia|Melanoma|Renal cell carcinoma|Prostate cancer|Endometrial cancer|Breast cancer|Small cell lung cancer|Non-small cell lung cancer|Human T-cell leukemia virus 1 infection|Human immunodeficiency virus 1 infection|Hepatitis B|Hepatitis C|Influenza A|Measles|Herpes simplex virus 1 infection|Human cytomegalovirus infection|Kaposi sarcoma-associated herpesvirus infection|Epstein-Barr virus infection|Human papillomavirus infection|Salmonella infection|Shigellosis|Yersinia infection|Tuberculosis|Toxoplasmosis|Chagas disease|Alzheimer disease|Spinocerebellar ataxia|Lipid and atherosclerosis|Fluid shear stress and atherosclerosis|Diabetic cardiomyopathy|Alcoholic liver disease|Non-alcoholic fatty liver disease|Insulin resistance|AGE-RAGE signaling pathway in diabetic complications|EGFR tyrosine kinase inhibitor resistance|Platinum drug resistance|Endocrine resistance","GO:0001649,GO:0001893,GO:0001934,GO:0001938,GO:0002042,GO:0003376,GO:0004672,GO:0004674,GO:0004712,GO:0005515,GO:0005516,GO:0005524,GO:0005547,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005819,GO:0005829,GO:0005886,GO:0005911,GO:0005938,GO:0005978,GO:0005979,GO:0006006,GO:0006417,GO:0006468,GO:0006469,GO:0006606,GO:0006809,GO:0006924,GO:0006954,GO:0006979,GO:0007165,GO:0007173,GO:0007186,GO:0007249,GO:0008283,GO:0008284,GO:0008286,GO:0008637,GO:0008643,GO:0009408,GO:0010467,GO:0010507,GO:0010595,GO:0010628,GO:0010629,GO:0010748,GO:0010761,GO:0010763,GO:0010765,GO:0010907,GO:0010918,GO:0010951,GO:0010975,GO:0015630,GO:0016020,GO:0016242,GO:0016301,GO:0016310,GO:0016567,GO:0018105,GO:0018107,GO:0019049,GO:0019221,GO:0019899,GO:0019901,GO:0022605,GO:0030027,GO:0030154,GO:0030235,GO:0030291,GO:0030307,GO:0030334,GO:0031295,GO:0031397,GO:0031641,GO:0031663,GO:0031929,GO:0031982,GO:0031999,GO:0032079,GO:0032091,GO:0032094,GO:0032287,GO:0032436,GO:0032869,GO:0032991,GO:0033138,GO:0034405,GO:0034614,GO:0035556,GO:0035655,GO:0035924,GO:0036064,GO:0036294,GO:0038061,GO:0042593,GO:0042802,GO:0042803,GO:0042981,GO:0043066,GO:0043154,GO:0043161,GO:0043276,GO:0043325,GO:0043488,GO:0043491,GO:0043536,GO:0045429,GO:0045600,GO:0045725,GO:0045737,GO:0045746,GO:0045824,GO:0045861,GO:0045893,GO:0045944,GO:0046326,GO:0046622,GO:0046777,GO:0046889,GO:0048009,GO:0048266,GO:0048661,GO:0051000,GO:0051091,GO:0051146,GO:0051247,GO:0060079,GO:0060416,GO:0060644,GO:0060716,GO:0070141,GO:0070848,GO:0071276,GO:0071356,GO:0071364,GO:0071380,GO:0071889,GO:0071901,GO:0072655,GO:0072656,GO:0090201,GO:0097011,GO:0097194,GO:0098794,GO:0098978,GO:0099104,GO:0099175,GO:0106310,GO:0110002,GO:0140052,GO:0150033,GO:1900087,GO:1900182,GO:1901796,GO:1902018,GO:1902176,GO:1903038,GO:1903078,GO:1903721,GO:1904263,GO:1905552,GO:1990090,GO:1990418,GO:2000010,GO:2000074,GO:2000402,GO:2001240","osteoblast differentiation|maternal placenta development|positive regulation of protein phosphorylation|positive regulation of endothelial cell proliferation|cell migration involved in sprouting angiogenesis|sphingosine-1-phosphate receptor signaling pathway|protein kinase activity|protein serine/threonine kinase activity|protein serine/threonine/tyrosine kinase activity|protein binding|calmodulin binding|ATP binding|phosphatidylinositol-3,4,5-trisphosphate binding|nucleus|nucleoplasm|cytoplasm|mitochondrion|spindle|cytosol|plasma membrane|cell-cell junction|cell cortex|glycogen biosynthetic process|regulation of glycogen biosynthetic process|glucose metabolic process|regulation of translation|protein phosphorylation|negative regulation of protein kinase activity|protein import into nucleus|nitric oxide biosynthetic process|activation-induced cell death of T cells|inflammatory response|response to oxidative stress|signal transduction|epidermal growth factor receptor signaling pathway|G protein-coupled receptor signaling pathway|canonical NF-kappaB signal transduction|cell population proliferation|positive regulation of cell population proliferation|insulin receptor signaling pathway|apoptotic mitochondrial changes|carbohydrate transport|response to heat|gene expression|negative regulation of autophagy|positive regulation of endothelial cell migration|positive regulation of gene expression|negative regulation of gene expression|negative regulation of long-chain fatty acid import across plasma membrane|fibroblast migration|positive regulation of fibroblast migration|positive regulation of sodium ion transport|positive regulation of glucose metabolic process|positive regulation of mitochondrial membrane potential|negative regulation of endopeptidase activity|regulation of neuron projection development|microtubule cytoskeleton|membrane|negative regulation of macroautophagy|kinase activity|phosphorylation|protein ubiquitination|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|mitigation of host antiviral defense response|cytokine-mediated signaling pathway|enzyme binding|protein kinase binding|mammalian oogenesis stage|lamellipodium|cell differentiation|nitric-oxide synthase regulator activity|protein serine/threonine kinase inhibitor activity|positive regulation of cell growth|regulation of cell migration|T cell costimulation|negative regulation of protein ubiquitination|regulation of myelination|lipopolysaccharide-mediated signaling pathway|TOR signaling|vesicle|negative regulation of fatty acid beta-oxidation|positive regulation of endodeoxyribonuclease activity|negative regulation of protein binding|response to food|peripheral nervous system myelin maintenance|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|cellular response to insulin stimulus|protein-containing complex|positive regulation of peptidyl-serine phosphorylation|response to fluid shear stress|cellular response to reactive oxygen species|intracellular signal transduction|interleukin-18-mediated signaling pathway|cellular response to vascular endothelial growth factor stimulus|ciliary basal body|cellular response to decreased oxygen levels|non-canonical NF-kappaB signal transduction|glucose homeostasis|identical protein binding|protein homodimerization activity|regulation of apoptotic process|negative regulation of apoptotic process|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|proteasome-mediated ubiquitin-dependent protein catabolic process|anoikis|phosphatidylinositol-3,4-bisphosphate binding|regulation of mRNA stability|phosphatidylinositol 3-kinase/protein kinase B signal transduction|positive regulation of blood vessel endothelial cell migration|positive regulation of nitric oxide biosynthetic process|positive regulation of fat cell differentiation|positive regulation of glycogen biosynthetic process|positive regulation of cyclin-dependent protein serine/threonine kinase activity|negative regulation of Notch signaling pathway|negative regulation of innate immune response|negative regulation of proteolysis|positive regulation of DNA-templated transcription|positive regulation of transcription by RNA polymerase II|positive regulation of glucose import|positive regulation of organ growth|protein autophosphorylation|positive regulation of lipid biosynthetic process|insulin-like growth factor receptor signaling pathway|behavioral response to pain|positive regulation of smooth muscle cell proliferation|positive regulation of nitric-oxide synthase activity|positive regulation of DNA-binding transcription factor activity|striated muscle cell differentiation|positive regulation of protein metabolic process|excitatory postsynaptic potential|response to growth hormone|mammary gland epithelial cell differentiation|labyrinthine layer blood vessel development|response to UV-A|response to growth factor|cellular response to cadmium ion|cellular response to tumor necrosis factor|cellular response to epidermal growth factor stimulus|cellular response to prostaglandin E stimulus|14-3-3 protein binding|negative regulation of protein serine/threonine kinase activity|establishment of protein localization to mitochondrion|maintenance of protein location in mitochondrion|negative regulation of release of cytochrome c from mitochondria|cellular response to granulocyte macrophage colony-stimulating factor stimulus|execution phase of apoptosis|postsynapse|glutamatergic synapse|potassium channel activator activity|regulation of postsynapse organization|protein serine kinase activity|regulation of tRNA methylation|cellular response to oxidised low-density lipoprotein particle stimulus|negative regulation of protein localization to lysosome|positive regulation of G1/S transition of mitotic cell cycle|positive regulation of protein localization to nucleus|regulation of signal transduction by p53 class mediator|negative regulation of cilium assembly|negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway|negative regulation of leukocyte cell-cell adhesion|positive regulation of protein localization to plasma membrane|positive regulation of I-kappaB phosphorylation|positive regulation of TORC1 signaling|positive regulation of protein localization to endoplasmic reticulum|cellular response to nerve growth factor stimulus|response to insulin-like growth factor stimulus|positive regulation of protein localization to cell surface|regulation of type B pancreatic cell development|negative regulation of lymphocyte migration|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand","WP4871,WP5216,WP4205,WP306,WP5083,WP2332,WP5115,WP5373,WP1971,WP1539,WP3651,WP185,WP4186,WP4216,WP5124,WP2572,WP3879,WP3584,WP3850,WP3286,WP4666,WP2374,WP5316,WP4262,WP4549,WP4806,WP2864,WP5413,WP364,WP2032,WP4223,WP61,WP4685,WP673,WP5200,WP2261,WP1559,WP2870,WP4018,WP1982,WP195,WP4936,WP4483,WP286,WP4239,WP2059,WP5353,WP2038,WP69,WP1544,WP5205,WP712,WP244,WP3859,WP2583,WP3935,WP5074,WP4808,WP395,WP2355,WP3844,WP3965,WP4564,WP5055,WP127,WP3929,WP5358,WP2366,WP4191,WP2035,WP4298,WP4481,WP3932,WP363,WP34,WP138,WP5181,WP382,WP5294,WP26,WP5158,WP75,WP3863,WP2380,WP710,WP481,WP3676,WP2034,WP2263,WP49,WP5072,WP3872,WP5322,WP4658,WP23,WP3303,WP4864,WP437,WP2037,WP4659,WP5144,WP2203,WP1403,WP707,WP2813,WP581,WP3680,WP3646,WP254,WP4396,WP4263,WP474,WP5372,WP4674,WP3658,WP5347,WP2036,WP205,WP231,WP4565,WP5192,WP2795,WP4255,WP4838,WP2018,WP4141,WP4566,WP2324,WP304,WP4155,WP5385,WP4136,WP4539,WP5087,WP4331,WP2112,WP4172,WP3888,WP5272,WP4217,WP5098,WP5191,WP3915,WP4747,WP4906,WP3931,WP1471","Kisspeptin/kisspeptin receptor system in the ovary|Warburg effect modulated by deubiquitinating enzymes and their substrates|MET in type 1 papillary renal cell carcinoma|Focal adhesion|Neuroinflammation and glutamatergic signaling|Interleukin-11 signaling pathway|Network map of SARS-CoV-2 signaling pathway|Role of hypoxia, angiogenesis, and FGF pathway in OA chondrocyte hypertrophy|Integrated cancer pathway|Angiogenesis|Pathways affected in adenoid cystic carcinoma|Integrin-mediated cell adhesion|Somatroph axis (GH) and its relationship to dietary restriction and aging|Chromosomal and microsatellite instability in colorectal cancer |Alzheimer's disease|Primary focal segmental glomerulosclerosis (FSGS)|4-hydroxytamoxifen, dexamethasone, and retinoic acids regulation of p27 expression|MECP2 and associated Rett syndrome|Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling|Copper homeostasis|Hepatitis B infection|Oncostatin M signaling pathway|Primary ovarian insufficiency|Breast cancer pathway|Fragile X syndrome|EGFR tyrosine kinase inhibitor resistance|Apoptosis-related network due to altered Notch3 in ovarian cancer|IL-24 Signaling pathway|IL6 signaling pathway|Thyroid stimulating hormone (TSH) signaling pathway|Ras signaling|Notch signaling pathway|Melanoma|ErbB signaling pathway|Dravet syndrome|Glioblastoma signaling pathways|Transcription factors regulate miRNAs related to cardiac hypertrophy|Extracellular vesicle-mediated signaling in recipient cells|Clear cell renal cell carcinoma pathways|Sterol regulatory element-binding proteins (SREBP) signaling|IL-1 signaling pathway|Perturbations to host-cell autophagy, induced by SARS-CoV-2 proteins|Relationship between inflammation, COX-2 and EGFR|IL-3 signaling pathway|Epithelial to mesenchymal transition in colorectal cancer|Alzheimer's disease and miRNA effects|A network map of Macrophage-stimulating protein (MSP) signaling|Microtubule cytoskeleton regulation|T-cell receptor signaling pathway|MicroRNAs in cardiomyocyte hypertrophy|Clock-controlled autophagy in bone metabolism|Estrogen signaling pathway|Alpha 6 beta 4 signaling pathway|TGF-beta signaling in thyroid cells for epithelial-mesenchymal transition|T cell receptor and co-stimulatory signaling|Leptin-insulin signaling overlap|Kallmann syndrome|Endochondral ossification with skeletal dysplasias|IL-4 signaling pathway|Corticotropin-releasing hormone signaling pathway|PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer|Lipid metabolism pathway|Neural crest cell migration during development|Burn wound healing|IL-5 signaling pathway|Chemokine signaling pathway|JAK-STAT signaling in the regulation of Beta-cells|Butyrate-induced histone acetylation|Caloric restriction and aging|Follicle stimulating hormone (FSH) signaling pathway|Acute viral myocarditis|Resistin as a regulator of inflammation|Focal adhesion: PI3K-Akt-mTOR-signaling pathway|Wnt signaling pathway|Ovarian infertility|Androgen receptor signaling pathway|Roles of ceramides in development of insulin resistance|MAPK signaling pathway|Sildenafil treatment|S1P receptor signal transduction|Urotensin-II-mediated signaling pathway|Toll-like receptor signaling pathway|T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection|Brain-derived neurotrophic factor (BDNF) signaling pathway|DNA damage response (only ATM dependent)|Insulin signaling|BDNF-TrkB signaling|Leptin signaling pathway|Androgen receptor network in prostate cancer|IL-2 signaling pathway|Modulators of TCR signaling and T cell activation|Regulation of apoptosis by parathyroid hormone-related protein|CKAP4 signaling pathway map|Small cell lung cancer|B cell receptor signaling pathway|RAC1/PAK1/p38/MMP2 pathway|Host-pathogen interaction of human coronaviruses - apoptosis|EGF/EGFR signaling pathway|Prolactin signaling pathway|Gastrin signaling pathway|NRP1-triggered signaling pathways in pancreatic cancer |Thymic stromal lymphopoietin (TSLP) signaling pathway|AMP-activated protein kinase signaling|DNA damage response|Mammary gland development pathway - Embryonic development (Stage 1 of 4)|EPO receptor signaling|Physico-chemical features and toxicity-associated pathways|Hepatitis C and hepatocellular carcinoma|Apoptosis|Nonalcoholic fatty liver disease|Pancreatic adenocarcinoma pathway|Endochondral ossification|Involvement of ??-secretase in neurodegenerative diseases|Head and neck squamous cell carcinoma|Wnt/beta-catenin signaling pathway in leukemia|IL-26 signaling pathways|TNF-related weak inducer of apoptosis (TWEAK) signaling pathway|IL-7 signaling pathway|TNF-alpha signaling pathway|Neural crest cell migration in cancer|Modulation of PI3K-Akt-mTOR signaling by bioactive sphingolipids|Cardiac hypertrophic response|Non-small cell lung cancer|Regucalcin in proximal tubule epithelial kidney cells|RANKL/RANK signaling pathway|PI3K/AKT/mTOR - vitamin D3 signaling|Translation inhibitors in chronically activated PDGFRA cells|AGE/RAGE pathway|Kit receptor signaling pathway|Endometrial cancer|Growth factors and hormones in Beta-cell proliferation|Fibrin complement receptor 3 signaling pathway|Synaptic signaling pathways associated with autism spectrum disorder|Pleural mesothelioma|Neovascularisation processes|IL-17 signaling pathway|PI3K-Akt signaling pathway|VEGFA-VEGFR2 signaling|LDL- influence on CD14 and TLR4|Ebola virus infection in host|T-cell activation SARS-CoV-2|Resolvin E1 and resolvin D1 signaling pathways promoting inflammation resolution|Angiopoietin-like protein 8 regulatory pathway|Netrin-UNC5B signaling pathway|3q29 copy number variation syndrome|Embryonic stem cell pluripotency pathways|Target of rapamycin signaling","R-HSA-109581,R-HSA-109582,R-HSA-109606,R-HSA-111447,R-HSA-114452,R-HSA-1227986,R-HSA-1257604,R-HSA-1257604,R-HSA-1266738,R-HSA-1280215,R-HSA-1280218,R-HSA-1358803,R-HSA-1430728,R-HSA-1445148,R-HSA-1474151,R-HSA-157118,R-HSA-162582,R-HSA-162582,R-HSA-1640170,R-HSA-1643685,R-HSA-165159,R-HSA-168256,R-HSA-186712,R-HSA-194138,R-HSA-195721,R-HSA-196854,R-HSA-198323,R-HSA-198323,R-HSA-198693,R-HSA-199418,R-HSA-199991,R-HSA-199991,R-HSA-201681,R-HSA-202131,R-HSA-203615,R-HSA-210745,R-HSA-211163,R-HSA-212436,R-HSA-212436,R-HSA-2219528,R-HSA-2262752,R-HSA-354192,R-HSA-3700989,R-HSA-372790,R-HSA-3769402,R-HSA-388396,R-HSA-388841,R-HSA-389356,R-HSA-389357,R-HSA-389513,R-HSA-392451,R-HSA-397795,R-HSA-4420097,R-HSA-449147,R-HSA-450385,R-HSA-450531,R-HSA-450604,R-HSA-453279,R-HSA-5218920,R-HSA-5357801,R-HSA-5628897,R-HSA-5633007,R-HSA-5653656,R-HSA-5653656,R-HSA-5663202,R-HSA-5663205,R-HSA-5674400,R-HSA-6785807,R-HSA-6804757,R-HSA-6804758,R-HSA-6804759,R-HSA-6806003,R-HSA-6807070,R-HSA-6811558,R-HSA-69202,R-HSA-69206,R-HSA-69242,R-HSA-69278,R-HSA-69656,R-HSA-73857,R-HSA-73857,R-HSA-74160,R-HSA-74160,R-HSA-76002,R-HSA-76009,R-HSA-8848021,R-HSA-8849469,R-HSA-8863795,R-HSA-8876198,R-HSA-8878166,R-HSA-8939211,R-HSA-8941332,R-HSA-8948751,R-HSA-8953854,R-HSA-8953897,R-HSA-8978934,R-HSA-9006925,R-HSA-9006925,R-HSA-9006927,R-HSA-9006931,R-HSA-9006934,R-HSA-9007101,R-HSA-9009391,R-HSA-9013694,R-HSA-9604323,R-HSA-9607240,R-HSA-9614085,R-HSA-9614399,R-HSA-9634638,R-HSA-9679506,R-HSA-9694516,R-HSA-9705683,R-HSA-9711123,R-HSA-9755511,R-HSA-9755779,R-HSA-9824446","Apoptosis|Hemostasis|Intrinsic Pathway for Apoptosis|Activation of BAD and translocation to mitochondria |Activation of BH3-only proteins|Signaling by ERBB2|PIP3 activates AKT signaling|PIP3 activates AKT signaling|Developmental Biology|Cytokine Signaling in Immune system|Adaptive Immune System|Downregulation of ERBB2:ERBB3 signaling|Metabolism|Translocation of SLC2A4 (GLUT4) to the plasma membrane|Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation|Signaling by NOTCH|Signal Transduction|Signal Transduction|Cell Cycle|Disease|MTOR signalling|Immune System|Regulation of beta-cell development|Signaling by VEGF|Signaling by WNT|Metabolism of vitamins and cofactors|AKT phosphorylates targets in the cytosol|AKT phosphorylates targets in the cytosol|AKT phosphorylates targets in the nucleus|Negative regulation of the PI3K/AKT network|Membrane Trafficking|Membrane Trafficking|TCF dependent signaling in response to WNT|Metabolism of nitric oxide: NOS3 activation and regulation|eNOS activation|Regulation of gene expression in beta cells|AKT-mediated inactivation of FOXO1A|Generic Transcription Pathway|Generic Transcription Pathway|PI3K/AKT Signaling in Cancer|Cellular responses to stress|Integrin signaling|Transcriptional Regulation by TP53|Signaling by GPCR|Deactivation of the beta-catenin transactivating complex|GPCR downstream signalling|Costimulation by the CD28 family|CD28 co-stimulation|CD28 dependent PI3K/Akt signaling|CTLA4 inhibitory signaling|G beta:gamma signalling through PI3Kgamma|G-protein beta:gamma signalling|VEGFA-VEGFR2 Pathway|Signaling by Interleukins|Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA|Regulation of mRNA stability by proteins that bind AU-rich elements|KSRP (KHSRP) binds and destabilizes mRNA|Mitotic G1 phase and G1/S transition|VEGFR2 mediated vascular permeability|Programmed Cell Death|TP53 Regulates Metabolic Genes|Regulation of TP53 Activity|Vesicle-mediated transport|Vesicle-mediated transport|Diseases of signal transduction by growth factor receptors and second messengers|Infectious disease|Constitutive Signaling by AKT1 E17K in Cancer|Interleukin-4 and Interleukin-13 signaling|Regulation of TP53 Degradation|Regulation of TP53 Activity through Acetylation|Regulation of TP53 Activity through Association with Co-factors|Regulation of TP53 Expression and Degradation|PTEN Regulation|PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling|Cyclin E associated events during G1/S transition |G1/S Transition|S Phase|Cell Cycle, Mitotic|Cyclin A:Cdk2-associated events at S phase entry|RNA Polymerase II Transcription|RNA Polymerase II Transcription|Gene expression (Transcription)|Gene expression (Transcription)|Platelet activation, signaling and aggregation|Platelet Aggregation (Plug Formation)|Signaling by PTK6|PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1|Downregulation of ERBB2 signaling|RAB GEFs exchange GTP for GDP on RABs|Transcriptional regulation by RUNX2|ESR-mediated signaling|RUNX2 regulates genes involved in cell migration|Regulation of PTEN stability and activity|Metabolism of RNA|Cellular responses to stimuli|Metabolism of cofactors|Intracellular signaling by second messengers|Intracellular signaling by second messengers|Signaling by Non-Receptor Tyrosine Kinases|Signaling by Nuclear Receptors|Signaling by Receptor Tyrosine Kinases|Rab regulation of trafficking|Extra-nuclear estrogen signaling|Signaling by NOTCH4|Negative regulation of NOTCH4 signaling|FLT3 Signaling|FOXO-mediated transcription|Regulation of localization of FOXO transcription factors|Estrogen-dependent nuclear events downstream of ESR-membrane signaling|SARS-CoV Infections|SARS-CoV-2 Infection|SARS-CoV-2-host interactions|Cellular response to chemical stress|KEAP1-NFE2L2 pathway|SARS-CoV-2 targets host intracellular signalling and regulatory pathways|Viral Infection Pathways"]
["AKT1S1",23.8755049226439,29.2174841847338,27.981138161282,33.0071302976849,22.5775532746155,27.4240997552774,26.2277584700956,28.0665931101797,21.8175517575541,32.0949110869369,33.9750744095103,24.5433234549204,20.5251306436872,23.1807340745379,21.4545107232542,23.299920941585,22.4726793089567,25.6211097261643,29.3416576289767,25.2843913502095,25.603271590473,30.1941334020355,24.1715744754372,22.7482588272272,23.6352150015595,28.8127822714077,23.4765309554494,30.073583259687,84335,"AKT1 substrate 1","protein_coding","hsa04152,hsa04150,hsa04140,hsa04211,hsa04213,hsa04714,hsa05131","AMPK signaling pathway|mTOR signaling pathway|Autophagy - animal|Longevity regulating pathway|Longevity regulating pathway - multiple species|Thermogenesis|Shigellosis","GO:0004860,GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0006469,GO:0030291,GO:0031931,GO:0032007,GO:0042981,GO:0043523,GO:0045792,GO:0048011,GO:1904262","protein kinase inhibitor activity|protein binding|nucleoplasm|cytoplasm|cytosol|negative regulation of protein kinase activity|protein serine/threonine kinase inhibitor activity|TORC1 complex|negative regulation of TOR signaling|regulation of apoptotic process|regulation of neuron apoptotic process|negative regulation of cell size|neurotrophin TRK receptor signaling pathway|negative regulation of TORC1 signaling","WP5115,WP4963,WP3850,WP4321,WP4549,WP4746,WP4018,WP4936,WP5358,WP5180,WP3932,WP4538,WP4577,WP4923,WP5087,WP3888,WP1471","Network map of SARS-CoV-2 signaling pathway|p53 transcriptional gene network|Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling|Thermogenesis|Fragile X syndrome|Thyroid hormones production and peripheral downstream signaling effects|Clear cell renal cell carcinoma pathways|Perturbations to host-cell autophagy, induced by SARS-CoV-2 proteins|JAK-STAT signaling in the regulation of Beta-cells|DYRK1A involvement regarding cell proliferation in brain development|Focal adhesion: PI3K-Akt-mTOR-signaling pathway|Regulatory circuits of the STAT3 signaling pathway|Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway|Autophagy|Pleural mesothelioma|VEGFA-VEGFR2 signaling|Target of rapamycin signaling","R-HSA-1257604,R-HSA-162582,R-HSA-1643685,R-HSA-165159,R-HSA-166208,R-HSA-198323,R-HSA-2219528,R-HSA-2262752,R-HSA-3371556,R-HSA-3371571,R-HSA-5663202,R-HSA-5674400,R-HSA-8953897,R-HSA-9006925","PIP3 activates AKT signaling|Signal Transduction|Disease|MTOR signalling|mTORC1-mediated signalling|AKT phosphorylates targets in the cytosol|PI3K/AKT Signaling in Cancer|Cellular responses to stress|Cellular response to heat stress|HSF1-dependent transactivation|Diseases of signal transduction by growth factor receptors and second messengers|Constitutive Signaling by AKT1 E17K in Cancer|Cellular responses to stimuli|Intracellular signaling by second messengers"]
["AKT2",14.5100078950614,15.5503491815587,15.5065112327097,16.3573887520389,14.4480763516729,15.5636507495605,15.448424769101,15.3755746614967,16.4350339989241,22.1059604955641,18.2490902387463,17.5772526529809,14.9837180673048,17.6598720930062,16.2331678647185,16.7785524194489,16.5869754153039,18.5294976144156,18.6433797332118,18.3003380534181,18.240446481873,17.9326985409416,17.1319003475091,17.0222064542137,16.742816577976,18.2332142033808,17.1456259241845,19.7329325515303,208,"AKT serine/threonine kinase 2","protein_coding","hsa04010,hsa04012,hsa04014,hsa04015,hsa04370,hsa04371,hsa04630,hsa04668,hsa04066,hsa04068,hsa04072,hsa04071,hsa04024,hsa04022,hsa04151,hsa04152,hsa04150,hsa04140,hsa04210,hsa04218,hsa04510,hsa04550,hsa04810,hsa04611,hsa04613,hsa04620,hsa04625,hsa04660,hsa04662,hsa04664,hsa04666,hsa04062,hsa04910,hsa04922,hsa04923,hsa04920,hsa04929,hsa04915,hsa04914,hsa04917,hsa04926,hsa04935,hsa04919,hsa04261,hsa04973,hsa04725,hsa04728,hsa04722,hsa04380,hsa04211,hsa04213,hsa05200,hsa05205,hsa05207,hsa05208,hsa05230,hsa05231,hsa05235,hsa05210,hsa05212,hsa05225,hsa05226,hsa05214,hsa05221,hsa05220,hsa05218,hsa05211,hsa05215,hsa05213,hsa05224,hsa05222,hsa05223,hsa05166,hsa05170,hsa05161,hsa05160,hsa05164,hsa05162,hsa05168,hsa05163,hsa05167,hsa05169,hsa05165,hsa05132,hsa05131,hsa05135,hsa05152,hsa05145,hsa05142,hsa05010,hsa05017,hsa05417,hsa05418,hsa05415,hsa04936,hsa04932,hsa04931,hsa04933,hsa01521,hsa01524,hsa01522","MAPK signaling pathway|ErbB signaling pathway|Ras signaling pathway|Rap1 signaling pathway|VEGF signaling pathway|Apelin signaling pathway|JAK-STAT signaling pathway|TNF signaling pathway|HIF-1 signaling pathway|FoxO signaling pathway|Phospholipase D signaling pathway|Sphingolipid signaling pathway|cAMP signaling pathway|cGMP-PKG signaling pathway|PI3K-Akt signaling pathway|AMPK signaling pathway|mTOR signaling pathway|Autophagy - animal|Apoptosis|Cellular senescence|Focal adhesion|Signaling pathways regulating pluripotency of stem cells|Regulation of actin cytoskeleton|Platelet activation|Neutrophil extracellular trap formation|Toll-like receptor signaling pathway|C-type lectin receptor signaling pathway|T cell receptor signaling pathway|B cell receptor signaling pathway|Fc epsilon RI signaling pathway|Fc gamma R-mediated phagocytosis|Chemokine signaling pathway|Insulin signaling pathway|Glucagon signaling pathway|Regulation of lipolysis in adipocytes|Adipocytokine signaling pathway|GnRH secretion|Estrogen signaling pathway|Progesterone-mediated oocyte maturation|Prolactin signaling pathway|Relaxin signaling pathway|Growth hormone synthesis, secretion and action|Thyroid hormone signaling pathway|Adrenergic signaling in cardiomyocytes|Carbohydrate digestion and absorption|Cholinergic synapse|Dopaminergic synapse|Neurotrophin signaling pathway|Osteoclast differentiation|Longevity regulating pathway|Longevity regulating pathway - multiple species|Pathways in cancer|Proteoglycans in cancer|Chemical carcinogenesis - receptor activation|Chemical carcinogenesis - reactive oxygen species|Central carbon metabolism in cancer|Choline metabolism in cancer|PD-L1 expression and PD-1 checkpoint pathway in cancer|Colorectal cancer|Pancreatic cancer|Hepatocellular carcinoma|Gastric cancer|Glioma|Acute myeloid leukemia|Chronic myeloid leukemia|Melanoma|Renal cell carcinoma|Prostate cancer|Endometrial cancer|Breast cancer|Small cell lung cancer|Non-small cell lung cancer|Human T-cell leukemia virus 1 infection|Human immunodeficiency virus 1 infection|Hepatitis B|Hepatitis C|Influenza A|Measles|Herpes simplex virus 1 infection|Human cytomegalovirus infection|Kaposi sarcoma-associated herpesvirus infection|Epstein-Barr virus infection|Human papillomavirus infection|Salmonella infection|Shigellosis|Yersinia infection|Tuberculosis|Toxoplasmosis|Chagas disease|Alzheimer disease|Spinocerebellar ataxia|Lipid and atherosclerosis|Fluid shear stress and atherosclerosis|Diabetic cardiomyopathy|Alcoholic liver disease|Non-alcoholic fatty liver disease|Insulin resistance|AGE-RAGE signaling pathway in diabetic complications|EGFR tyrosine kinase inhibitor resistance|Platinum drug resistance|Endocrine resistance","GO:0001934,GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005769,GO:0005829,GO:0005886,GO:0005938,GO:0005978,GO:0006006,GO:0006417,GO:0007165,GO:0008284,GO:0008286,GO:0008643,GO:0010748,GO:0010907,GO:0010918,GO:0016310,GO:0018105,GO:0030334,GO:0030335,GO:0031340,GO:0032000,GO:0032287,GO:0032587,GO:0032869,GO:0032991,GO:0035556,GO:0036211,GO:0043066,GO:0043231,GO:0045444,GO:0045725,GO:0046326,GO:0046872,GO:0051726,GO:0060644,GO:0065002,GO:0071486,GO:0072659,GO:0090314,GO:0097473,GO:0106310,GO:0140677,GO:2000147","positive regulation of protein phosphorylation|protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|early endosome|cytosol|plasma membrane|cell cortex|glycogen biosynthetic process|glucose metabolic process|regulation of translation|signal transduction|positive regulation of cell population proliferation|insulin receptor signaling pathway|carbohydrate transport|negative regulation of long-chain fatty acid import across plasma membrane|positive regulation of glucose metabolic process|positive regulation of mitochondrial membrane potential|phosphorylation|peptidyl-serine phosphorylation|regulation of cell migration|positive regulation of cell migration|positive regulation of vesicle fusion|positive regulation of fatty acid beta-oxidation|peripheral nervous system myelin maintenance|ruffle membrane|cellular response to insulin stimulus|protein-containing complex|intracellular signal transduction|protein modification process|negative regulation of apoptotic process|intracellular membrane-bounded organelle|fat cell differentiation|positive regulation of glycogen biosynthetic process|positive regulation of glucose import|metal ion binding|regulation of cell cycle|mammary gland epithelial cell differentiation|intracellular protein transmembrane transport|cellular response to high light intensity|protein localization to plasma membrane|positive regulation of protein targeting to membrane|retinal rod cell apoptotic process|protein serine kinase activity|molecular function activator activity|positive regulation of cell motility","WP4871,WP4205,WP306,WP5373,WP185,WP4216,WP5124,WP4666,WP4262,WP5101,WP4806,WP4223,WP4685,WP673,WP2261,WP1559,WP4483,WP4239,WP2059,WP1544,WP3965,WP4564,WP5102,WP3929,WP5358,WP4481,WP3932,WP382,WP5294,WP26,WP75,WP710,WP481,WP4658,WP5318,WP5144,WP1403,WP4396,WP4263,WP5372,WP4674,WP3635,WP2036,WP4565,WP2795,WP4255,WP2018,WP4566,WP4155,WP5385,WP4539,WP5087,WP4172,WP3915,WP3634,WP3931","Kisspeptin/kisspeptin receptor system in the ovary|MET in type 1 papillary renal cell carcinoma|Focal adhesion|Role of hypoxia, angiogenesis, and FGF pathway in OA chondrocyte hypertrophy|Integrin-mediated cell adhesion|Chromosomal and microsatellite instability in colorectal cancer |Alzheimer's disease|Hepatitis B infection|Breast cancer pathway|Congenital generalized lipodystrophy|EGFR tyrosine kinase inhibitor resistance|Ras signaling|Melanoma|ErbB signaling pathway|Glioblastoma signaling pathways|Transcription factors regulate miRNAs related to cardiac hypertrophy|Relationship between inflammation, COX-2 and EGFR|Epithelial to mesenchymal transition in colorectal cancer|Alzheimer's disease and miRNA effects|MicroRNAs in cardiomyocyte hypertrophy|Lipid metabolism pathway|Neural crest cell migration during development|Familial partial lipodystrophy|Chemokine signaling pathway|JAK-STAT signaling in the regulation of Beta-cells|Resistin as a regulator of inflammation|Focal adhesion: PI3K-Akt-mTOR-signaling pathway|MAPK signaling pathway|Sildenafil treatment|S1P receptor signal transduction|Toll-like receptor signaling pathway|DNA damage response (only ATM dependent)|Insulin signaling|Small cell lung cancer|Female steroid hormones in cardiomyocyte energy metabolism|NRP1-triggered signaling pathways in pancreatic cancer |AMP-activated protein kinase signaling|Nonalcoholic fatty liver disease|Pancreatic adenocarcinoma pathway|Involvement of ??-secretase in neurodegenerative diseases|Head and neck squamous cell carcinoma|Insulin signaling in adipocytes (diabetic condition)|TNF-related weak inducer of apoptosis (TWEAK) signaling pathway|Neural crest cell migration in cancer|Cardiac hypertrophic response|Non-small cell lung cancer|RANKL/RANK signaling pathway|Translation inhibitors in chronically activated PDGFRA cells|Endometrial cancer|Growth factors and hormones in Beta-cell proliferation|Synaptic signaling pathways associated with autism spectrum disorder|Pleural mesothelioma|PI3K-Akt signaling pathway|Angiopoietin-like protein 8 regulatory pathway|Insulin signaling in adipocytes (normal condition)|Embryonic stem cell pluripotency pathways","R-HSA-109581,R-HSA-109606,R-HSA-109703,R-HSA-109704,R-HSA-109704,R-HSA-111447,R-HSA-112399,R-HSA-112399,R-HSA-114452,R-HSA-1227986,R-HSA-1257604,R-HSA-1257604,R-HSA-1266738,R-HSA-1280215,R-HSA-1280218,R-HSA-1358803,R-HSA-1445148,R-HSA-162582,R-HSA-162582,R-HSA-1640170,R-HSA-1643685,R-HSA-165158,R-HSA-165159,R-HSA-165160,R-HSA-165181,R-HSA-168256,R-HSA-186712,R-HSA-194138,R-HSA-195721,R-HSA-198323,R-HSA-198323,R-HSA-198693,R-HSA-199418,R-HSA-199991,R-HSA-199991,R-HSA-201681,R-HSA-210745,R-HSA-211163,R-HSA-212436,R-HSA-212436,R-HSA-2219528,R-HSA-2262752,R-HSA-2404192,R-HSA-2404192,R-HSA-2428924,R-HSA-2428924,R-HSA-2428928,R-HSA-2428928,R-HSA-3700989,R-HSA-372790,R-HSA-3769402,R-HSA-388396,R-HSA-388841,R-HSA-389356,R-HSA-389357,R-HSA-389513,R-HSA-392451,R-HSA-397795,R-HSA-4420097,R-HSA-453279,R-HSA-5218920,R-HSA-5357801,R-HSA-5628897,R-HSA-5633007,R-HSA-5653656,R-HSA-5653656,R-HSA-5663202,R-HSA-5663205,R-HSA-5674400,R-HSA-6804757,R-HSA-6804758,R-HSA-6804759,R-HSA-6806003,R-HSA-6807070,R-HSA-69202,R-HSA-69206,R-HSA-69242,R-HSA-69278,R-HSA-69656,R-HSA-73857,R-HSA-73857,R-HSA-74160,R-HSA-74160,R-HSA-74751,R-HSA-74751,R-HSA-74752,R-HSA-74752,R-HSA-8863795,R-HSA-8876198,R-HSA-8878166,R-HSA-8939211,R-HSA-8941332,R-HSA-8948751,R-HSA-8953897,R-HSA-9006925,R-HSA-9006925,R-HSA-9006931,R-HSA-9006934,R-HSA-9006934,R-HSA-9007101,R-HSA-9009391,R-HSA-9607240,R-HSA-9614085,R-HSA-9614399,R-HSA-9634638,R-HSA-9679506,R-HSA-9694516,R-HSA-9705683,R-HSA-9711123,R-HSA-9755511,R-HSA-9755779,R-HSA-9824446","Apoptosis|Intrinsic Pathway for Apoptosis|PKB-mediated events|PI3K Cascade|PI3K Cascade|Activation of BAD and translocation to mitochondria |IRS-mediated signalling|IRS-mediated signalling|Activation of BH3-only proteins|Signaling by ERBB2|PIP3 activates AKT signaling|PIP3 activates AKT signaling|Developmental Biology|Cytokine Signaling in Immune system|Adaptive Immune System|Downregulation of ERBB2:ERBB3 signaling|Translocation of SLC2A4 (GLUT4) to the plasma membrane|Signal Transduction|Signal Transduction|Cell Cycle|Disease|Activation of AKT2|MTOR signalling|PDE3B signalling|Inhibition of TSC complex formation by PKB|Immune System|Regulation of beta-cell development|Signaling by VEGF|Signaling by WNT|AKT phosphorylates targets in the cytosol|AKT phosphorylates targets in the cytosol|AKT phosphorylates targets in the nucleus|Negative regulation of the PI3K/AKT network|Membrane Trafficking|Membrane Trafficking|TCF dependent signaling in response to WNT|Regulation of gene expression in beta cells|AKT-mediated inactivation of FOXO1A|Generic Transcription Pathway|Generic Transcription Pathway|PI3K/AKT Signaling in Cancer|Cellular responses to stress|Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)|Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)|IGF1R signaling cascade|IGF1R signaling cascade|IRS-related events triggered by IGF1R|IRS-related events triggered by IGF1R|Transcriptional Regulation by TP53|Signaling by GPCR|Deactivation of the beta-catenin transactivating complex|GPCR downstream signalling|Costimulation by the CD28 family|CD28 co-stimulation|CD28 dependent PI3K/Akt signaling|CTLA4 inhibitory signaling|G beta:gamma signalling through PI3Kgamma|G-protein beta:gamma signalling|VEGFA-VEGFR2 Pathway|Mitotic G1 phase and G1/S transition|VEGFR2 mediated vascular permeability|Programmed Cell Death|TP53 Regulates Metabolic Genes|Regulation of TP53 Activity|Vesicle-mediated transport|Vesicle-mediated transport|Diseases of signal transduction by growth factor receptors and second messengers|Infectious disease|Constitutive Signaling by AKT1 E17K in Cancer|Regulation of TP53 Degradation|Regulation of TP53 Activity through Acetylation|Regulation of TP53 Activity through Association with Co-factors|Regulation of TP53 Expression and Degradation|PTEN Regulation|Cyclin E associated events during G1/S transition |G1/S Transition|S Phase|Cell Cycle, Mitotic|Cyclin A:Cdk2-associated events at S phase entry|RNA Polymerase II Transcription|RNA Polymerase II Transcription|Gene expression (Transcription)|Gene expression (Transcription)|Insulin receptor signalling cascade|Insulin receptor signalling cascade|Signaling by Insulin receptor|Signaling by Insulin receptor|Downregulation of ERBB2 signaling|RAB GEFs exchange GTP for GDP on RABs|Transcriptional regulation by RUNX2|ESR-mediated signaling|RUNX2 regulates genes involved in cell migration|Regulation of PTEN stability and activity|Cellular responses to stimuli|Intracellular signaling by second messengers|Intracellular signaling by second messengers|Signaling by Nuclear Receptors|Signaling by Receptor Tyrosine Kinases|Signaling by Receptor Tyrosine Kinases|Rab regulation of trafficking|Extra-nuclear estrogen signaling|FLT3 Signaling|FOXO-mediated transcription|Regulation of localization of FOXO transcription factors|Estrogen-dependent nuclear events downstream of ESR-membrane signaling|SARS-CoV Infections|SARS-CoV-2 Infection|SARS-CoV-2-host interactions|Cellular response to chemical stress|KEAP1-NFE2L2 pathway|SARS-CoV-2 targets host intracellular signalling and regulatory pathways|Viral Infection Pathways"]
["AKT3",7.4509311809552,8.38641768608412,6.89564590791137,6.4160340817347,8.03349556525911,7.32189627937214,6.91964306364342,6.47449304322805,8.58948849857408,6.80973183048212,6.97197284647464,7.95751561523782,8.80011639600213,7.41576199065964,8.76824923161333,8.19128604530798,7.5444392594374,7.21151796708233,6.59229377768826,8.73652893607784,7.77145075204929,7.61600933826505,9.31702661780186,8.12338320385982,7.52307857204512,7.02045543703153,7.78355937805855,6.77603522688847,10000,"AKT serine/threonine kinase 3","protein_coding","hsa04010,hsa04012,hsa04014,hsa04015,hsa04370,hsa04371,hsa04630,hsa04668,hsa04066,hsa04068,hsa04072,hsa04071,hsa04024,hsa04022,hsa04151,hsa04152,hsa04150,hsa04140,hsa04210,hsa04218,hsa04510,hsa04550,hsa04810,hsa04611,hsa04613,hsa04620,hsa04625,hsa04660,hsa04662,hsa04664,hsa04666,hsa04062,hsa04910,hsa04922,hsa04923,hsa04920,hsa04929,hsa04915,hsa04914,hsa04917,hsa04926,hsa04935,hsa04919,hsa04261,hsa04973,hsa04725,hsa04728,hsa04722,hsa04380,hsa04211,hsa04213,hsa05200,hsa05205,hsa05207,hsa05208,hsa05230,hsa05231,hsa05235,hsa05210,hsa05212,hsa05225,hsa05226,hsa05214,hsa05221,hsa05220,hsa05218,hsa05211,hsa05215,hsa05213,hsa05224,hsa05222,hsa05223,hsa05166,hsa05170,hsa05161,hsa05160,hsa05164,hsa05162,hsa05168,hsa05163,hsa05167,hsa05169,hsa05165,hsa05132,hsa05131,hsa05135,hsa05152,hsa05145,hsa05142,hsa05010,hsa05017,hsa05417,hsa05418,hsa05415,hsa04936,hsa04932,hsa04931,hsa04933,hsa01521,hsa01524,hsa01522","MAPK signaling pathway|ErbB signaling pathway|Ras signaling pathway|Rap1 signaling pathway|VEGF signaling pathway|Apelin signaling pathway|JAK-STAT signaling pathway|TNF signaling pathway|HIF-1 signaling pathway|FoxO signaling pathway|Phospholipase D signaling pathway|Sphingolipid signaling pathway|cAMP signaling pathway|cGMP-PKG signaling pathway|PI3K-Akt signaling pathway|AMPK signaling pathway|mTOR signaling pathway|Autophagy - animal|Apoptosis|Cellular senescence|Focal adhesion|Signaling pathways regulating pluripotency of stem cells|Regulation of actin cytoskeleton|Platelet activation|Neutrophil extracellular trap formation|Toll-like receptor signaling pathway|C-type lectin receptor signaling pathway|T cell receptor signaling pathway|B cell receptor signaling pathway|Fc epsilon RI signaling pathway|Fc gamma R-mediated phagocytosis|Chemokine signaling pathway|Insulin signaling pathway|Glucagon signaling pathway|Regulation of lipolysis in adipocytes|Adipocytokine signaling pathway|GnRH secretion|Estrogen signaling pathway|Progesterone-mediated oocyte maturation|Prolactin signaling pathway|Relaxin signaling pathway|Growth hormone synthesis, secretion and action|Thyroid hormone signaling pathway|Adrenergic signaling in cardiomyocytes|Carbohydrate digestion and absorption|Cholinergic synapse|Dopaminergic synapse|Neurotrophin signaling pathway|Osteoclast differentiation|Longevity regulating pathway|Longevity regulating pathway - multiple species|Pathways in cancer|Proteoglycans in cancer|Chemical carcinogenesis - receptor activation|Chemical carcinogenesis - reactive oxygen species|Central carbon metabolism in cancer|Choline metabolism in cancer|PD-L1 expression and PD-1 checkpoint pathway in cancer|Colorectal cancer|Pancreatic cancer|Hepatocellular carcinoma|Gastric cancer|Glioma|Acute myeloid leukemia|Chronic myeloid leukemia|Melanoma|Renal cell carcinoma|Prostate cancer|Endometrial cancer|Breast cancer|Small cell lung cancer|Non-small cell lung cancer|Human T-cell leukemia virus 1 infection|Human immunodeficiency virus 1 infection|Hepatitis B|Hepatitis C|Influenza A|Measles|Herpes simplex virus 1 infection|Human cytomegalovirus infection|Kaposi sarcoma-associated herpesvirus infection|Epstein-Barr virus infection|Human papillomavirus infection|Salmonella infection|Shigellosis|Yersinia infection|Tuberculosis|Toxoplasmosis|Chagas disease|Alzheimer disease|Spinocerebellar ataxia|Lipid and atherosclerosis|Fluid shear stress and atherosclerosis|Diabetic cardiomyopathy|Alcoholic liver disease|Non-alcoholic fatty liver disease|Insulin resistance|AGE-RAGE signaling pathway in diabetic complications|EGFR tyrosine kinase inhibitor resistance|Platinum drug resistance|Endocrine resistance","GO:0000002,GO:0001938,GO:0004672,GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0006468,GO:0007165,GO:0016020,GO:0018105,GO:0032008,GO:0035556,GO:0043536,GO:0045766,GO:0045793,GO:0048854,GO:0048873,GO:0090050,GO:0106310,GO:1905564,GO:1905653,GO:2000773","mitochondrial genome maintenance|positive regulation of endothelial cell proliferation|protein kinase activity|protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|cytoplasm|protein phosphorylation|signal transduction|membrane|peptidyl-serine phosphorylation|positive regulation of TOR signaling|intracellular signal transduction|positive regulation of blood vessel endothelial cell migration|positive regulation of angiogenesis|positive regulation of cell size|brain morphogenesis|homeostasis of number of cells within a tissue|positive regulation of cell migration involved in sprouting angiogenesis|protein serine kinase activity|positive regulation of vascular endothelial cell proliferation|positive regulation of artery morphogenesis|negative regulation of cellular senescence","WP4205,WP306,WP5373,WP185,WP4216,WP5124,WP4666,WP4262,WP4806,WP4223,WP4685,WP673,WP4746,WP2261,WP4483,WP3981,WP4239,WP2059,WP2643,WP3965,WP4564,WP3287,WP3929,WP5358,WP4481,WP3932,WP382,WP5294,WP26,WP75,WP710,WP4658,WP5144,WP4396,WP4263,WP5372,WP4674,WP4565,WP4255,WP4566,WP4155,WP5385,WP4539,WP5087,WP4172,WP3931","MET in type 1 papillary renal cell carcinoma|Focal adhesion|Role of hypoxia, angiogenesis, and FGF pathway in OA chondrocyte hypertrophy|Integrin-mediated cell adhesion|Chromosomal and microsatellite instability in colorectal cancer |Alzheimer's disease|Hepatitis B infection|Breast cancer pathway|EGFR tyrosine kinase inhibitor resistance|Ras signaling|Melanoma|ErbB signaling pathway|Thyroid hormones production and peripheral downstream signaling effects|Glioblastoma signaling pathways|Relationship between inflammation, COX-2 and EGFR|miRNA regulation of prostate cancer signaling pathways|Epithelial to mesenchymal transition in colorectal cancer|Alzheimer's disease and miRNA effects|Nanoparticle-mediated activation of receptor signaling|Lipid metabolism pathway|Neural crest cell migration during development|Overview of nanoparticle effects|Chemokine signaling pathway|JAK-STAT signaling in the regulation of Beta-cells|Resistin as a regulator of inflammation|Focal adhesion: PI3K-Akt-mTOR-signaling pathway|MAPK signaling pathway|Sildenafil treatment|S1P receptor signal transduction|Toll-like receptor signaling pathway|DNA damage response (only ATM dependent)|Small cell lung cancer|NRP1-triggered signaling pathways in pancreatic cancer |Nonalcoholic fatty liver disease|Pancreatic adenocarcinoma pathway|Involvement of ??-secretase in neurodegenerative diseases|Head and neck squamous cell carcinoma|Neural crest cell migration in cancer|Non-small cell lung cancer|Translation inhibitors in chronically activated PDGFRA cells|Endometrial cancer|Growth factors and hormones in Beta-cell proliferation|Synaptic signaling pathways associated with autism spectrum disorder|Pleural mesothelioma|PI3K-Akt signaling pathway|Embryonic stem cell pluripotency pathways","R-HSA-109581,R-HSA-109606,R-HSA-111447,R-HSA-114452,R-HSA-1227986,R-HSA-1257604,R-HSA-1257604,R-HSA-1266738,R-HSA-1280215,R-HSA-1280218,R-HSA-1358803,R-HSA-162582,R-HSA-162582,R-HSA-1640170,R-HSA-1643685,R-HSA-168256,R-HSA-186712,R-HSA-194138,R-HSA-198323,R-HSA-198323,R-HSA-198693,R-HSA-199418,R-HSA-199991,R-HSA-210745,R-HSA-211163,R-HSA-212436,R-HSA-212436,R-HSA-2219528,R-HSA-2262752,R-HSA-3700989,R-HSA-372790,R-HSA-388396,R-HSA-388841,R-HSA-389356,R-HSA-389357,R-HSA-389513,R-HSA-392451,R-HSA-397795,R-HSA-4420097,R-HSA-453279,R-HSA-5218920,R-HSA-5357801,R-HSA-5628897,R-HSA-5633007,R-HSA-5653656,R-HSA-5663202,R-HSA-5663205,R-HSA-5674400,R-HSA-6804757,R-HSA-6804758,R-HSA-6804759,R-HSA-6806003,R-HSA-6807070,R-HSA-69202,R-HSA-69206,R-HSA-69242,R-HSA-69278,R-HSA-69656,R-HSA-73857,R-HSA-73857,R-HSA-74160,R-HSA-74160,R-HSA-8863795,R-HSA-8876198,R-HSA-8878166,R-HSA-8939211,R-HSA-8941332,R-HSA-8948751,R-HSA-8953897,R-HSA-9006925,R-HSA-9006925,R-HSA-9006931,R-HSA-9006934,R-HSA-9007101,R-HSA-9009391,R-HSA-9607240,R-HSA-9614085,R-HSA-9614399,R-HSA-9634638,R-HSA-9679506,R-HSA-9694516,R-HSA-9705683,R-HSA-9711123,R-HSA-9755511,R-HSA-9755779,R-HSA-9824446","Apoptosis|Intrinsic Pathway for Apoptosis|Activation of BAD and translocation to mitochondria |Activation of BH3-only proteins|Signaling by ERBB2|PIP3 activates AKT signaling|PIP3 activates AKT signaling|Developmental Biology|Cytokine Signaling in Immune system|Adaptive Immune System|Downregulation of ERBB2:ERBB3 signaling|Signal Transduction|Signal Transduction|Cell Cycle|Disease|Immune System|Regulation of beta-cell development|Signaling by VEGF|AKT phosphorylates targets in the cytosol|AKT phosphorylates targets in the cytosol|AKT phosphorylates targets in the nucleus|Negative regulation of the PI3K/AKT network|Membrane Trafficking|Regulation of gene expression in beta cells|AKT-mediated inactivation of FOXO1A|Generic Transcription Pathway|Generic Transcription Pathway|PI3K/AKT Signaling in Cancer|Cellular responses to stress|Transcriptional Regulation by TP53|Signaling by GPCR|GPCR downstream signalling|Costimulation by the CD28 family|CD28 co-stimulation|CD28 dependent PI3K/Akt signaling|CTLA4 inhibitory signaling|G beta:gamma signalling through PI3Kgamma|G-protein beta:gamma signalling|VEGFA-VEGFR2 Pathway|Mitotic G1 phase and G1/S transition|VEGFR2 mediated vascular permeability|Programmed Cell Death|TP53 Regulates Metabolic Genes|Regulation of TP53 Activity|Vesicle-mediated transport|Diseases of signal transduction by growth factor receptors and second messengers|Infectious disease|Constitutive Signaling by AKT1 E17K in Cancer|Regulation of TP53 Degradation|Regulation of TP53 Activity through Acetylation|Regulation of TP53 Activity through Association with Co-factors|Regulation of TP53 Expression and Degradation|PTEN Regulation|Cyclin E associated events during G1/S transition |G1/S Transition|S Phase|Cell Cycle, Mitotic|Cyclin A:Cdk2-associated events at S phase entry|RNA Polymerase II Transcription|RNA Polymerase II Transcription|Gene expression (Transcription)|Gene expression (Transcription)|Downregulation of ERBB2 signaling|RAB GEFs exchange GTP for GDP on RABs|Transcriptional regulation by RUNX2|ESR-mediated signaling|RUNX2 regulates genes involved in cell migration|Regulation of PTEN stability and activity|Cellular responses to stimuli|Intracellular signaling by second messengers|Intracellular signaling by second messengers|Signaling by Nuclear Receptors|Signaling by Receptor Tyrosine Kinases|Rab regulation of trafficking|Extra-nuclear estrogen signaling|FLT3 Signaling|FOXO-mediated transcription|Regulation of localization of FOXO transcription factors|Estrogen-dependent nuclear events downstream of ESR-membrane signaling|SARS-CoV Infections|SARS-CoV-2 Infection|SARS-CoV-2-host interactions|Cellular response to chemical stress|KEAP1-NFE2L2 pathway|SARS-CoV-2 targets host intracellular signalling and regulatory pathways|Viral Infection Pathways"]
["AKTIP",5.38391798856078,4.53748404357941,5.8798581628677,5.65525171880873,6.280915805676,5.28792621857435,5.73219650526909,5.41413312292215,6.23518343583265,4.58573063149165,5.26131643742813,5.63775734947333,5.64251319483738,5.29876588967866,7.25506054001821,6.05974645024067,5.93339052104844,5.26112646407406,6.87152490534496,6.04897625121221,5.53101522150544,6.22294715156474,8.22576905524314,7.0758722988521,6.20013148731954,6.06400724750825,6.37949210745908,5.72432209110493,64400,"AKT interacting protein","protein_coding",null,null,"GO:0001934,GO:0005515,GO:0005634,GO:0005829,GO:0005886,GO:0006915,GO:0007032,GO:0007040,GO:0008333,GO:0015031,GO:0019787,GO:0019788,GO:0032092,GO:0045022,GO:0045116,GO:0070695,GO:1905719","positive regulation of protein phosphorylation|protein binding|nucleus|cytosol|plasma membrane|apoptotic process|endosome organization|lysosome organization|endosome to lysosome transport|protein transport|ubiquitin-like protein transferase activity|NEDD8 transferase activity|positive regulation of protein binding|early endosome to late endosome transport|protein neddylation|FHF complex|protein localization to perinuclear region of cytoplasm"]
["ALAD",20.0580850489711,20.3302968148,20.6234073374102,19.6113450162981,20.6950811332905,22.2577429399878,20.4477905616151,21.7889388533734,19.1574737276732,20.4188399382813,19.1558735512686,19.714517411017,19.4395088455212,19.1642902043288,19.6222423616346,19.5597231731786,20.5776914034705,21.0210896202457,18.4512334748777,21.0683086853698,20.9178604098726,19.4852075521008,18.8737619313284,19.4690436196757,21.3269655845438,18.674040138705,18.2553258413112,19.2443917167054,210,"aminolevulinate dehydratase","protein_coding","hsa00860","Porphyrin metabolism","GO:0001666,GO:0003824,GO:0004655,GO:0005576,GO:0005634,GO:0005829,GO:0006782,GO:0006783,GO:0006979,GO:0008270,GO:0009410,GO:0009635,GO:0010039,GO:0010043,GO:0010044,GO:0010212,GO:0010266,GO:0010269,GO:0014823,GO:0032025,GO:0032496,GO:0033197,GO:0034774,GO:0042802,GO:0043200,GO:0045471,GO:0046685,GO:0046686,GO:0046689,GO:0051260,GO:0051384,GO:0051597,GO:0070062,GO:0070541,GO:0070542,GO:0071284,GO:0071353,GO:1901799,GO:1904813,GO:1904854","response to hypoxia|catalytic activity|porphobilinogen synthase activity|extracellular region|nucleus|cytosol|protoporphyrinogen IX biosynthetic process|heme biosynthetic process|response to oxidative stress|zinc ion binding|response to xenobiotic stimulus|response to herbicide|response to iron ion|response to zinc ion|response to aluminum ion|response to ionizing radiation|response to vitamin B1|response to selenium ion|response to activity|response to cobalt ion|response to lipopolysaccharide|response to vitamin E|secretory granule lumen|identical protein binding|response to amino acid|response to ethanol|response to arsenic-containing substance|response to cadmium ion|response to mercury ion|protein homooligomerization|response to glucocorticoid|response to methylmercury|extracellular exosome|response to platinum ion|response to fatty acid|cellular response to lead ion|cellular response to interleukin-4|negative regulation of proteasomal protein catabolic process|ficolin-1-rich granule lumen|proteasome core complex binding","WP561,WP5169","Heme biosynthesis|Hemesynthesis defects and porphyrias","R-HSA-1430728,R-HSA-168249,R-HSA-168256,R-HSA-189445,R-HSA-189451,R-HSA-6798695","Metabolism|Innate Immune System|Immune System|Metabolism of porphyrins|Heme biosynthesis|Neutrophil degranulation"]
["ALAS1",24.767322402499,27.1596932414653,25.6773616638975,25.9050611765349,24.960892231741,25.4468661416988,25.405182538011,25.0594708679611,20.608187842216,22.7473092015073,23.775988736097,20.4144686847161,20.4518936630066,21.567505193928,23.0131147068675,23.44167578636,18.9930030068815,19.1290099397211,18.1869627330608,19.0386917796346,19.1930494905248,19.9635806914999,15.212870505851,18.9790842701471,19.9976482529111,20.0912727502971,17.0087556793665,19.7138439989034,211,"5'-aminolevulinate synthase 1","protein_coding","hsa00260,hsa00860","Glycine, serine and threonine metabolism|Porphyrin metabolism","GO:0003870,GO:0005515,GO:0005654,GO:0005739,GO:0005743,GO:0005759,GO:0005829,GO:0006782,GO:0006783,GO:0030170,GO:0042541,GO:0042802,GO:0048821,GO:1903412","5-aminolevulinate synthase activity|protein binding|nucleoplasm|mitochondrion|mitochondrial inner membrane|mitochondrial matrix|cytosol|protoporphyrinogen IX biosynthetic process|heme biosynthetic process|pyridoxal phosphate binding|hemoglobin biosynthetic process|identical protein binding|erythrocyte development|response to bile acid","WP2882,WP561,WP2875,WP5169","Nuclear receptors meta-pathway|Heme biosynthesis|Constitutive androstane receptor pathway|Hemesynthesis defects and porphyrias","R-HSA-1430728,R-HSA-1592230,R-HSA-1852241,R-HSA-189445,R-HSA-189451,R-HSA-1989781,R-HSA-2151201,R-HSA-400206,R-HSA-556833","Metabolism|Mitochondrial biogenesis|Organelle biogenesis and maintenance|Metabolism of porphyrins|Heme biosynthesis|PPARA activates gene expression|Transcriptional activation of mitochondrial biogenesis|Regulation of lipid metabolism by PPARalpha|Metabolism of lipids"]
["ALAS2",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.012660853977498,0,0,0,0,0,0,0,0,0,0,0.012380049466274,212,"5'-aminolevulinate synthase 2","protein_coding","hsa00260,hsa00860","Glycine, serine and threonine metabolism|Porphyrin metabolism","GO:0001666,GO:0003870,GO:0005515,GO:0005739,GO:0005743,GO:0005759,GO:0006782,GO:0006783,GO:0006879,GO:0030170,GO:0030218,GO:0032364,GO:0042541,GO:0048821","response to hypoxia|5-aminolevulinate synthase activity|protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial matrix|protoporphyrinogen IX biosynthetic process|heme biosynthetic process|intracellular iron ion homeostasis|pyridoxal phosphate binding|erythrocyte differentiation|intracellular oxygen homeostasis|hemoglobin biosynthetic process|erythrocyte development","WP561,WP5169","Heme biosynthesis|Hemesynthesis defects and porphyrias","R-HSA-1430728,R-HSA-189445,R-HSA-189451","Metabolism|Metabolism of porphyrins|Heme biosynthesis"]
["ALB",0,0.0224418670110044,0.0110754747024726,0.0565701953741417,0.0115275618469955,0.0221560260980703,0.0220130462864625,0.0462725262495191,0.0830634962753292,0.0113620526671532,0.144227530069262,0.0712127585568692,0.0673132297819971,0.0562351226183727,0.0658270355651173,0.100668394190075,0.0226842609119812,0.032746131164672,0.0109030674032486,0.0113442749426318,0.0445385908427571,0.0448540500722721,0.0116462664287569,0.0115253760427459,0.0584792510153388,0,0.0456630799036215,0.0443622954178784,213,"albumin","protein_coding","hsa04918","Thyroid hormone synthesis","GO:0001895,GO:0003677,GO:0005504,GO:0005507,GO:0005515,GO:0005576,GO:0005615,GO:0005634,GO:0005737,GO:0005783,GO:0005788,GO:0005794,GO:0006810,GO:0009267,GO:0015643,GO:0016209,GO:0019825,GO:0030170,GO:0031093,GO:0032991,GO:0042802,GO:0043066,GO:0043069,GO:0051087,GO:0051659,GO:0070062,GO:0072562,GO:0098869,GO:0140272,GO:1903981","retina homeostasis|DNA binding|fatty acid binding|copper ion binding|protein binding|extracellular region|extracellular space|nucleus|cytoplasm|endoplasmic reticulum|endoplasmic reticulum lumen|Golgi apparatus|transport|cellular response to starvation|toxic substance binding|antioxidant activity|oxygen binding|pyridoxal phosphate binding|platelet alpha granule lumen|protein-containing complex|identical protein binding|negative regulation of apoptotic process|negative regulation of programmed cell death|protein-folding chaperone binding|maintenance of mitochondrion location|extracellular exosome|blood microparticle|cellular oxidant detoxification|exogenous protein binding|enterobactin binding","WP5115,WP1533,WP2806,WP15,WP176,WP3888","Network map of SARS-CoV-2 signaling pathway|Vitamin B12 metabolism|Complement system|Selenium micronutrient network|Folate metabolism|VEGFA-VEGFR2 signaling","R-HSA-109582,R-HSA-114608,R-HSA-1430728,R-HSA-159418,R-HSA-174824,R-HSA-189445,R-HSA-189451,R-HSA-189483,R-HSA-194068,R-HSA-2168880,R-HSA-2173782,R-HSA-2262752,R-HSA-381426,R-HSA-382551,R-HSA-392499,R-HSA-556833,R-HSA-5653656,R-HSA-597592,R-HSA-76002,R-HSA-76005,R-HSA-8953897,R-HSA-8957275,R-HSA-8957322,R-HSA-8963899,R-HSA-8964058,R-HSA-9707564,R-HSA-9711123,R-HSA-9748784,R-HSA-9749641,R-HSA-9757110,R-HSA-9793528","Hemostasis|Platelet degranulation |Metabolism|Recycling of bile acids and salts|Plasma lipoprotein assembly, remodeling, and clearance|Metabolism of porphyrins|Heme biosynthesis|Heme degradation|Bile acid and bile salt metabolism|Scavenging of heme from plasma|Binding and Uptake of Ligands by Scavenger Receptors|Cellular responses to stress|Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)|Transport of small molecules|Metabolism of proteins|Metabolism of lipids|Vesicle-mediated transport|Post-translational protein modification|Platelet activation, signaling and aggregation|Response to elevated platelet cytosolic Ca2+|Cellular responses to stimuli|Post-translational protein phosphorylation|Metabolism of steroids|Plasma lipoprotein remodeling|HDL remodeling|Cytoprotection by HMOX1|Cellular response to chemical stress|Drug ADME|Aspirin ADME|Prednisone ADME|Ciprofloxacin ADME"]
["ALCAM",33.8373509440126,26.874836371594,20.3617105980601,19.2741334702664,31.671798568656,24.2787250337344,21.3525388706217,20.5172238805548,30.9664108859977,19.3517169028656,17.0868905187448,24.0721394751942,33.2516547452374,18.9724134152751,24.0039149928693,24.5969273041793,33.7010455013239,29.8563443928492,28.1499217186863,35.0821150657574,34.7144312145988,31.2702145119989,40.1506357282953,39.5929190834647,36.0653377227175,28.2551649146428,35.3835919038777,25.2720920811126,214,"activated leukocyte cell adhesion molecule","protein_coding","hsa04514","Cell adhesion molecules","GO:0001772,GO:0002250,GO:0005102,GO:0005515,GO:0005886,GO:0005925,GO:0007155,GO:0007157,GO:0007165,GO:0008045,GO:0009897,GO:0030424,GO:0030425,GO:0031290,GO:0042802,GO:0043025,GO:0048846,GO:0070062,GO:1990138","immunological synapse|adaptive immune response|signaling receptor binding|protein binding|plasma membrane|focal adhesion|cell adhesion|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules|signal transduction|motor neuron axon guidance|external side of plasma membrane|axon|dendrite|retinal ganglion cell axon guidance|identical protein binding|neuronal cell body|axon extension involved in axon guidance|extracellular exosome|neuron projection extension",null,null,"R-HSA-1266738,R-HSA-373760,R-HSA-422475,R-HSA-9675108","Developmental Biology|L1CAM interactions|Axon guidance|Nervous system development"]
["ALDH16A1",7.41210722334434,5.96425952345555,6.20688644862083,7.41096378394007,6.33536800958055,5.98429783285396,5.4767018989865,6.47462546792962,5.13320630776988,7.61472991139223,6.74631530261983,5.9486135899651,4.43186205954326,4.03686067167774,4.50039996414109,4.02281169408317,8.55974167385456,9.94827602777389,11.1575354855472,9.05292143158176,7.98500990164113,9.53164512457506,8.61264223788328,7.99053883924387,7.72863186103635,9.64139832983291,9.00279948144078,10.4443481288659,126133,"aldehyde dehydrogenase 16 family member A1","protein_coding",null,null,"GO:0005515,GO:0016020,GO:0016620","protein binding|membrane|oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"]
["ALDH18A1",20.9389398671574,20.0495088027124,21.6219744444627,18.3228389802839,20.3239104340892,19.4483296736425,22.0645754597027,18.3732271850754,21.2765751591246,19.4788112802858,20.862430380397,21.3849384531356,20.928345236565,21.8445333811068,20.8361452368881,21.1940739829483,21.0166578406758,22.0999255185488,19.7742469105762,21.778450778698,19.3878706783557,20.4842993113869,19.9006214009386,20.6150716935075,19.9999517810582,20.0147277492375,19.9058746079448,19.0618632081409,5832,"aldehyde dehydrogenase 18 family member A1","protein_coding","hsa00330","Arginine and proline metabolism","GO:0003723,GO:0004349,GO:0004350,GO:0005515,GO:0005524,GO:0005739,GO:0005743,GO:0006536,GO:0006561,GO:0006592,GO:0009266,GO:0016310,GO:0019240,GO:0042802,GO:0055129","RNA binding|glutamate 5-kinase activity|glutamate-5-semialdehyde dehydrogenase activity|protein binding|ATP binding|mitochondrion|mitochondrial inner membrane|glutamate metabolic process|proline biosynthetic process|ornithine biosynthetic process|response to temperature stimulus|phosphorylation|citrulline biosynthetic process|identical protein binding|L-proline biosynthetic process","WP497,WP5312,WP3925","Urea cycle and metabolism of amino groups|Metabolic pathways of fibroblasts|Amino acid metabolism","R-HSA-1430728,R-HSA-71291,R-HSA-8964539","Metabolism|Metabolism of amino acids and derivatives|Glutamate and glutamine metabolism"]
["ALDH1A1",0.617317906150605,1.00308507200665,0.760672691218722,0.468701342016863,0.464979826504885,0.736693153072408,0.503958027698428,0.844953769819911,0.0905534775711485,0.0619329445239625,0.0241896584122331,0.0129390230043293,0.0366914909474865,0.110350696244927,0.0239209249787361,0.256073626760536,0.0618243513643573,0.095197086146661,0,0,0.0971094275531489,0.0122246546296686,0.0253928614405626,0.0753878366154807,0.0255009711011544,0.0122200634512306,0.0871160499831138,0.0725437822255621,216,"aldehyde dehydrogenase 1 family member A1","protein_coding","hsa00830","Retinol metabolism","GO:0001523,GO:0001758,GO:0004029,GO:0005096,GO:0005497,GO:0005515,GO:0005737,GO:0005829,GO:0006081,GO:0009449,GO:0018479,GO:0019145,GO:0030392,GO:0030424,GO:0036438,GO:0042572,GO:0043878,GO:0045202,GO:0051287,GO:0070062,GO:0106373,GO:0110095,GO:0120163","retinoid metabolic process|retinal dehydrogenase activity|aldehyde dehydrogenase (NAD+) activity|GTPase activator activity|androgen binding|protein binding|cytoplasm|cytosol|cellular aldehyde metabolic process|gamma-aminobutyric acid biosynthetic process|benzaldehyde dehydrogenase (NAD+) activity|aminobutyraldehyde dehydrogenase activity|fructosamine catabolic process|axon|maintenance of lens transparency|retinol metabolic process|glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity|synapse|NAD binding|extracellular exosome|3-deoxyglucosone dehydrogenase activity|cellular detoxification of aldehyde|negative regulation of cold-induced thermogenesis","WP3996,WP5188,WP1589,WP5178,WP2855,WP3925,WP716,WP206","Ethanol effects on histone modifications|Retinol metabolism|Folate-alcohol and cancer pathway hypotheses|Disorders of fructose metabolism|Dopaminergic neurogenesis|Amino acid metabolism|Vitamin A and carotenoid metabolism|Fatty acid omega-oxidation","R-HSA-1430728,R-HSA-162582,R-HSA-211859,R-HSA-211945,R-HSA-5362517,R-HSA-5365859,R-HSA-5652084,R-HSA-70350,R-HSA-71384,R-HSA-71387,R-HSA-9006931","Metabolism|Signal Transduction|Biological oxidations|Phase I - Functionalization of compounds|Signaling by Retinoic Acid|RA biosynthesis pathway|Fructose metabolism|Fructose catabolism|Ethanol oxidation|Metabolism of carbohydrates|Signaling by Nuclear Receptors"]
["ALDH1A2",0,0.00730896039340722,0.0360710657000425,7.36960640991527E-3,0.0150173767505044,0.0144317330769928,0.0286772011200495,0,0.0309171019692339,0,0.00722655701710956,0.0231928667762893,0.0292304694131249,0.051281686789103303,0.0214388221588217,0.00728580009895863,0,0,0,0.00738930109575649,0,0,0.0151720175539963,0,0.0457098364549769,0.00730138340757681,0.022307612082335,0,8854,"aldehyde dehydrogenase 1 family member A2","protein_coding","hsa00830","Retinol metabolism","GO:0001568,GO:0001758,GO:0001822,GO:0001889,GO:0002138,GO:0003007,GO:0004028,GO:0004029,GO:0005737,GO:0005829,GO:0006776,GO:0007494,GO:0008283,GO:0008284,GO:0008285,GO:0009855,GO:0009954,GO:0010628,GO:0014032,GO:0016331,GO:0016918,GO:0021915,GO:0021983,GO:0030182,GO:0030324,GO:0030902,GO:0031016,GO:0031076,GO:0032355,GO:0032526,GO:0033189,GO:0034097,GO:0035115,GO:0035799,GO:0042572,GO:0042573,GO:0042574,GO:0042904,GO:0043065,GO:0048471,GO:0048566,GO:0048738,GO:0051289,GO:0060324,GO:0071300,GO:0090242,GO:1905562","blood vessel development|retinal dehydrogenase activity|kidney development|liver development|retinoic acid biosynthetic process|heart morphogenesis|3-chloroallyl aldehyde dehydrogenase activity|aldehyde dehydrogenase (NAD+) activity|cytoplasm|cytosol|vitamin A metabolic process|midgut development|cell population proliferation|positive regulation of cell population proliferation|negative regulation of cell population proliferation|determination of bilateral symmetry|proximal/distal pattern formation|positive regulation of gene expression|neural crest cell development|morphogenesis of embryonic epithelium|retinal binding|neural tube development|pituitary gland development|neuron differentiation|lung development|hindbrain development|pancreas development|embryonic camera-type eye development|response to estradiol|response to retinoic acid|response to vitamin A|response to cytokine|embryonic forelimb morphogenesis|ureter maturation|retinol metabolic process|retinoic acid metabolic process|retinal metabolic process|9-cis-retinoic acid biosynthetic process|positive regulation of apoptotic process|perinuclear region of cytoplasm|embryonic digestive tract development|cardiac muscle tissue development|protein homotetramerization|face development|cellular response to retinoic acid|retinoic acid receptor signaling pathway involved in somitogenesis|regulation of vascular endothelial cell proliferation","WP3996,WP4657,WP5236,WP5052,WP716","Ethanol effects on histone modifications|22q11.2 copy number variation syndrome|Markers of kidney cell lineage|Nephrogenesis|Vitamin A and carotenoid metabolism","R-HSA-162582,R-HSA-5362517,R-HSA-5365859,R-HSA-9006931","Signal Transduction|Signaling by Retinoic Acid|RA biosynthesis pathway|Signaling by Nuclear Receptors"]
["ALDH1A3",29.194148353649,28.8475838666656,27.065631441051,22.9908351390189,32.8781416235994,30.6327658437464,26.9116312421551,26.905609907568,19.0167449042765,14.1673726209381,12.8398065327609,17.5433010478855,21.7998296172286,20.3284213446008,19.2372506207779,20.902193889206,30.6085323933907,26.8181909506157,27.1829436803579,33.2371231908124,31.2587661056957,28.6290769035089,30.1175001350245,31.0347246022985,32.6185428080477,25.9159752113479,28.0551350036135,24.2680874307559,220,"aldehyde dehydrogenase 1 family member A3","protein_coding","hsa00830","Retinol metabolism","GO:0001758,GO:0002072,GO:0002138,GO:0004029,GO:0004030,GO:0005737,GO:0005829,GO:0006915,GO:0007626,GO:0021768,GO:0031076,GO:0042472,GO:0042572,GO:0042573,GO:0042574,GO:0042803,GO:0043065,GO:0048048,GO:0050885,GO:0051289,GO:0060013,GO:0060166,GO:0060324,GO:0070062,GO:0070324,GO:0070384,GO:0070403","retinal dehydrogenase activity|optic cup morphogenesis involved in camera-type eye development|retinoic acid biosynthetic process|aldehyde dehydrogenase (NAD+) activity|aldehyde dehydrogenase [NAD(P)+] activity|cytoplasm|cytosol|apoptotic process|locomotory behavior|nucleus accumbens development|embryonic camera-type eye development|inner ear morphogenesis|retinol metabolic process|retinoic acid metabolic process|retinal metabolic process|protein homodimerization activity|positive regulation of apoptotic process|embryonic eye morphogenesis|neuromuscular process controlling balance|protein homotetramerization|righting reflex|olfactory pit development|face development|extracellular exosome|thyroid hormone binding|Harderian gland development|NAD+ binding","WP3996,WP716","Ethanol effects on histone modifications|Vitamin A and carotenoid metabolism","R-HSA-162582,R-HSA-5362517,R-HSA-5365859,R-HSA-9006931","Signal Transduction|Signaling by Retinoic Acid|RA biosynthesis pathway|Signaling by Nuclear Receptors"]
["ALDH1A3-AS1",1.06486948004505,0.409042664670693,0.531911662369572,0.648114801041351,0.860451194689705,0.461523096183152,0.764241237243356,0.809930325405058,0.641981996182882,0.460207729579933,0.414060306415121,0.628386322578451,0.464145657073868,0.442532962899101,0.453897885668944,0.407746509260636,0.574251002290358,0.290533117811992,0.346984805242662,0.544821084893604,0.357576142327257,0.496366174206023,0.663776728484781,0.646883254746628,0.950839450194577,0.441048671455306,0.729905368610101,0.330491518044909,101927751,"ALDH1A3 antisense RNA 1","non_coding"]
["ALDH1B1",7.52628602524438,7.91576360840493,7.67508004233525,7.84869704895369,6.95706484890139,8.02615555174609,7.49815856872315,8.0079982366225,7.61393168281159,7.96532399527904,7.87533300112571,8.25094423035509,6.98466569394694,7.14240198898987,7.20053619802804,6.1599803103682,7.81828048986594,8.39659074530681,7.11586104769466,7.84471538960548,7.18534968442041,8.41213166051749,6.65292969742741,6.55851597687916,7.13581987742497,7.76781902410834,6.61334312323671,7.31956518989625,219,"aldehyde dehydrogenase 1 family member B1","protein_coding","hsa00010,hsa00053,hsa00620,hsa00071,hsa00561,hsa00280,hsa00310,hsa00330,hsa00340,hsa00380,hsa00410,hsa00770,hsa04936","Glycolysis / Gluconeogenesis|Ascorbate and aldarate metabolism|Pyruvate metabolism|Fatty acid degradation|Glycerolipid metabolism|Valine, leucine and isoleucine degradation|Lysine degradation|Arginine and proline metabolism|Histidine metabolism|Tryptophan metabolism|beta-Alanine metabolism|Pantothenate and CoA biosynthesis|Alcoholic liver disease","GO:0004029,GO:0005654,GO:0005739,GO:0005759,GO:0005829,GO:0005975,GO:0006068,GO:0043878,GO:0051287","aldehyde dehydrogenase (NAD+) activity|nucleoplasm|mitochondrion|mitochondrial matrix|cytosol|carbohydrate metabolic process|ethanol catabolic process|glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity|NAD binding",null,null,"R-HSA-1430728,R-HSA-211859,R-HSA-211945,R-HSA-71384","Metabolism|Biological oxidations|Phase I - Functionalization of compounds|Ethanol oxidation"]
["ALDH1L1",0,0,0,0,0,0,0,0,0,0,0,0,0,0.0277382094296776,0,0,0,0,0,0,0,0,0,0,0,0,0,0,10840,"aldehyde dehydrogenase 1 family member L1","protein_coding","hsa00670","One carbon pool by folate","GO:0004029,GO:0005829,GO:0006730,GO:0006740,GO:0009058,GO:0009258,GO:0016155,GO:0070062","aldehyde dehydrogenase (NAD+) activity|cytosol|one-carbon metabolic process|NADPH regeneration|biosynthetic process|10-formyltetrahydrofolate catabolic process|formyltetrahydrofolate dehydrogenase activity|extracellular exosome","WP4259,WP1589,WP241","Disorders of folate metabolism and transport|Folate-alcohol and cancer pathway hypotheses|One-carbon metabolism","R-HSA-1430728,R-HSA-196757,R-HSA-196849,R-HSA-196854","Metabolism|Metabolism of folate and pterines|Metabolism of water-soluble vitamins and cofactors|Metabolism of vitamins and cofactors"]
["ALDH1L1-AS1",0,0,0,0,0.0602756952411552,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,100874204,"ALDH1L1 antisense RNA 1","non_coding"]
["ALDH1L2",12.8409845967105,14.9409504783536,14.1645309258672,9.93409296637301,15.9974764765617,14.2171208280432,14.1468217775344,12.2955511217476,15.198938482299,9.85605466779859,7.29513887449318,10.5103961309105,16.6809435755158,14.3588794412561,15.2009084932858,17.6991967678829,6.93387216494848,6.0561259362643,3.33576345139486,6.8499145249816,7.08910652208595,5.75328468071108,4.69465994243416,6.35927507294237,7.43663991944426,4.93666742643263,4.22991968563233,4.55401959731457,160428,"aldehyde dehydrogenase 1 family member L2","protein_coding","hsa00670","One carbon pool by folate","GO:0004029,GO:0005515,GO:0005654,GO:0005739,GO:0005759,GO:0006635,GO:0006730,GO:0006740,GO:0009058,GO:0009258,GO:0016155,GO:0046655,GO:0070062","aldehyde dehydrogenase (NAD+) activity|protein binding|nucleoplasm|mitochondrion|mitochondrial matrix|fatty acid beta-oxidation|one-carbon metabolic process|NADPH regeneration|biosynthetic process|10-formyltetrahydrofolate catabolic process|formyltetrahydrofolate dehydrogenase activity|folic acid metabolic process|extracellular exosome","WP4259","Disorders of folate metabolism and transport","R-HSA-1430728,R-HSA-196757,R-HSA-196849,R-HSA-196854","Metabolism|Metabolism of folate and pterines|Metabolism of water-soluble vitamins and cofactors|Metabolism of vitamins and cofactors"]
["ALDH2",8.6442585410789,9.05881770493934,9.56871318878431,10.2534233503238,9.72787686589048,11.1303152673212,10.2535646041356,11.0974570660842,12.1888144168313,12.7109592199924,11.8096740946924,12.8438688797105,13.6661662147325,14.6734968317936,11.3061485071341,13.8766471921806,8.80698457595528,8.04779299443173,7.09804398710768,7.90582413965616,8.57136702551589,8.01569108110263,7.07252143548292,7.77862227211306,8.22910282920667,8.32879443130011,7.36906996137885,8.65141319363658,217,"aldehyde dehydrogenase 2 family member","protein_coding","hsa00010,hsa00053,hsa00620,hsa00071,hsa00561,hsa00280,hsa00310,hsa00330,hsa00340,hsa00380,hsa00410,hsa00770,hsa04936","Glycolysis / Gluconeogenesis|Ascorbate and aldarate metabolism|Pyruvate metabolism|Fatty acid degradation|Glycerolipid metabolism|Valine, leucine and isoleucine degradation|Lysine degradation|Arginine and proline metabolism|Histidine metabolism|Tryptophan metabolism|beta-Alanine metabolism|Pantothenate and CoA biosynthesis|Alcoholic liver disease","GO:0004029,GO:0004030,GO:0005739,GO:0005759,GO:0005975,GO:0006066,GO:0006068,GO:0008957,GO:0009055,GO:0018547,GO:0022900,GO:0043878,GO:0046185,GO:0051287,GO:0070062,GO:0106435,GO:1903179,GO:1905627","aldehyde dehydrogenase (NAD+) activity|aldehyde dehydrogenase [NAD(P)+] activity|mitochondrion|mitochondrial matrix|carbohydrate metabolic process|alcohol metabolic process|ethanol catabolic process|phenylacetaldehyde dehydrogenase activity|electron transfer activity|nitroglycerin reductase activity|electron transport chain|glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity|aldehyde catabolic process|NAD binding|extracellular exosome|carboxylesterase activity|regulation of dopamine biosynthetic process|regulation of serotonin biosynthetic process","WP3996,WP4966,WP465,WP206","Ethanol effects on histone modifications|Fluoroacetic acid toxicity|Tryptophan metabolism|Fatty acid omega-oxidation","R-HSA-112311,R-HSA-112315,R-HSA-112316,R-HSA-1430728,R-HSA-211859,R-HSA-211945,R-HSA-380612,R-HSA-380615,R-HSA-397014,R-HSA-445355,R-HSA-71384","Neurotransmitter clearance|Transmission across Chemical Synapses|Neuronal System|Metabolism|Biological oxidations|Phase I - Functionalization of compounds|Metabolism of serotonin|Serotonin clearance from the synaptic cleft|Muscle contraction|Smooth Muscle Contraction|Ethanol oxidation"]
["ALDH3A1",0.501952674234522,0.593574393942293,0.75145451535674,0.572477850318692,0.649563896426199,0.630602094083415,0.556917884660529,0.791532081978988,0.259271097188397,0.326651866437406,0.465678315845366,0.450410842055085,0.419296152213182,0.607888373789647,0.466813179152226,0.411612871619879,0.339122280015301,0.257324383338558,0.0940368986528301,0.306572321958718,0.198470752538166,0.315933801984269,0.140625589980851,0.212062278874078,0.477472636561323,0.38026721857901,0.295376584743953,0.401747246909957,218,"aldehyde dehydrogenase 3 family member A1","protein_coding","hsa00010,hsa00340,hsa00350,hsa00360,hsa00410,hsa00980,hsa00982","Glycolysis / Gluconeogenesis|Histidine metabolism|Tyrosine metabolism|Phenylalanine metabolism|beta-Alanine metabolism|Metabolism of xenobiotics by cytochrome P450|Drug metabolism - cytochrome P450","GO:0004028,GO:0004029,GO:0004030,GO:0005515,GO:0005615,GO:0005737,GO:0005783,GO:0005829,GO:0005886,GO:0006081,GO:0006629,GO:0006805,GO:0008106,GO:0018479","3-chloroallyl aldehyde dehydrogenase activity|aldehyde dehydrogenase (NAD+) activity|aldehyde dehydrogenase [NAD(P)+] activity|protein binding|extracellular space|cytoplasm|endoplasmic reticulum|cytosol|plasma membrane|cellular aldehyde metabolic process|lipid metabolic process|xenobiotic metabolic process|alcohol dehydrogenase (NADP+) activity|benzaldehyde dehydrogenase (NAD+) activity","WP2882,WP2873,WP2884","Nuclear receptors meta-pathway|Aryl hydrocarbon receptor pathway|NRF2 pathway","R-HSA-1430728,R-HSA-211859,R-HSA-211945","Metabolism|Biological oxidations|Phase I - Functionalization of compounds"]
["ALDH3A2",25.9752661684086,26.7557048209854,28.3627738604605,26.5518130507868,29.1448622305708,28.2821373515254,30.7463313402295,28.6364872908499,31.287780309318,26.1729506791799,29.6828937104226,32.9550012138631,35.6698189231823,34.5523969186399,33.8713710180837,34.488695369644,26.7706768512992,25.4199861284515,26.7022340306339,26.4251872484058,26.1308169828005,24.9361553033643,28.9084272468496,29.0098277537207,26.271605807871,25.1346183177216,27.8552506459898,26.3327091895841,224,"aldehyde dehydrogenase 3 family member A2","protein_coding","hsa00010,hsa00053,hsa00620,hsa00071,hsa00561,hsa00280,hsa00310,hsa00330,hsa00340,hsa00380,hsa00410,hsa00770,hsa04936","Glycolysis / Gluconeogenesis|Ascorbate and aldarate metabolism|Pyruvate metabolism|Fatty acid degradation|Glycerolipid metabolism|Valine, leucine and isoleucine degradation|Lysine degradation|Arginine and proline metabolism|Histidine metabolism|Tryptophan metabolism|beta-Alanine metabolism|Pantothenate and CoA biosynthesis|Alcoholic liver disease","GO:0004028,GO:0004029,GO:0005515,GO:0005737,GO:0005778,GO:0005789,GO:0005829,GO:0006081,GO:0006631,GO:0007417,GO:0007422,GO:0008544,GO:0033306,GO:0042803,GO:0043231,GO:0043878,GO:0046458,GO:0046577,GO:0050061,GO:0052814","3-chloroallyl aldehyde dehydrogenase activity|aldehyde dehydrogenase (NAD+) activity|protein binding|cytoplasm|peroxisomal membrane|endoplasmic reticulum membrane|cytosol|cellular aldehyde metabolic process|fatty acid metabolic process|central nervous system development|peripheral nervous system development|epidermis development|phytol metabolic process|protein homodimerization activity|intracellular membrane-bounded organelle|glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity|hexadecanal metabolic process|long-chain-alcohol oxidase activity|long-chain-aldehyde dehydrogenase activity|medium-chain-aldehyde dehydrogenase activity","WP4549,WP4966","Fragile X syndrome|Fluoroacetic acid toxicity","R-HSA-1430728,R-HSA-162582,R-HSA-1660661,R-HSA-194315,R-HSA-389599,R-HSA-390918,R-HSA-428157,R-HSA-556833,R-HSA-8978868,R-HSA-9012999,R-HSA-9603798,R-HSA-9609507,R-HSA-9609507,R-HSA-9609523,R-HSA-9609523,R-HSA-9696270,R-HSA-9696273,R-HSA-9716542","Metabolism|Signal Transduction|Sphingolipid de novo biosynthesis|Signaling by Rho GTPases|Alpha-oxidation of phytanate|Peroxisomal lipid metabolism|Sphingolipid metabolism|Metabolism of lipids|Fatty acid metabolism|RHO GTPase cycle|Class I peroxisomal membrane protein import|Protein localization|Protein localization|Insertion of tail-anchored proteins into the endoplasmic reticulum membrane|Insertion of tail-anchored proteins into the endoplasmic reticulum membrane|RND2 GTPase cycle|RND1 GTPase cycle|Signaling by Rho GTPases, Miro GTPases and RHOBTB3"]
["ALDH3B1",36.4095785084751,45.825673900062,48.0302549236324,47.3512240151784,42.5438372831106,49.5735839027763,49.5343418824548,51.9813815710246,25.7938861938458,33.6798599125097,26.1051979502137,26.524043250517,25.7044760795724,29.8190113312688,23.5007191866849,28.0219608502706,31.8941897485845,35.9152818792257,36.178088507447,37.0459824141966,34.1243250913279,37.0262257664779,27.3946810943105,33.1219702246506,31.1535800000649,37.3674580369173,28.5285766767833,38.2143406313925,221,"aldehyde dehydrogenase 3 family member B1","protein_coding","hsa00010,hsa00340,hsa00350,hsa00360,hsa00410,hsa00980,hsa00982","Glycolysis / Gluconeogenesis|Histidine metabolism|Tyrosine metabolism|Phenylalanine metabolism|beta-Alanine metabolism|Metabolism of xenobiotics by cytochrome P450|Drug metabolism - cytochrome P450","GO:0004028,GO:0004029,GO:0004030,GO:0005515,GO:0005737,GO:0005829,GO:0005886,GO:0006066,GO:0006068,GO:0006081,GO:0006629,GO:0006979,GO:0018477,GO:0018479,GO:0030148,GO:0030667,GO:0031982,GO:0034599,GO:0035579,GO:0046185,GO:0070062","3-chloroallyl aldehyde dehydrogenase activity|aldehyde dehydrogenase (NAD+) activity|aldehyde dehydrogenase [NAD(P)+] activity|protein binding|cytoplasm|cytosol|plasma membrane|alcohol metabolic process|ethanol catabolic process|cellular aldehyde metabolic process|lipid metabolic process|response to oxidative stress|benzaldehyde dehydrogenase (NADP+) activity|benzaldehyde dehydrogenase (NAD+) activity|sphingolipid biosynthetic process|secretory granule membrane|vesicle|cellular response to oxidative stress|specific granule membrane|aldehyde catabolic process|extracellular exosome",null,null,"R-HSA-1430728,R-HSA-1660661,R-HSA-168249,R-HSA-168256,R-HSA-428157,R-HSA-556833,R-HSA-6798695","Metabolism|Sphingolipid de novo biosynthesis|Innate Immune System|Immune System|Sphingolipid metabolism|Metabolism of lipids|Neutrophil degranulation"]
["ALDH4A1",7.11669931742558,6.97661624769129,5.49074043131211,7.46835074368816,6.8988847734541,7.13049572311137,6.15746859374455,7.26377783295615,6.50840666468132,9.39839578546288,8.01470000806157,7.95644836095768,6.43758824210675,7.21617789070745,7.00913925963697,6.75537114503553,6.56268176136892,7.10803008045381,7.33892099584775,6.90571263675137,6.9000948058517,6.86450441617746,5.81358795256168,6.22675968813462,6.74332182055628,6.73911780897164,5.87831761012818,7.54107507601462,8659,"aldehyde dehydrogenase 4 family member A1","protein_coding","hsa00250,hsa00330","Alanine, aspartate and glutamate metabolism|Arginine and proline metabolism","GO:0003842,GO:0004029,GO:0005515,GO:0005739,GO:0005759,GO:0005829,GO:0006560,GO:0006562,GO:0009055,GO:0010133,GO:0019470,GO:0022900,GO:0042802","1-pyrroline-5-carboxylate dehydrogenase activity|aldehyde dehydrogenase (NAD+) activity|protein binding|mitochondrion|mitochondrial matrix|cytosol|proline metabolic process|proline catabolic process|electron transfer activity|proline catabolic process to glutamate|4-hydroxyproline catabolic process|electron transport chain|identical protein binding","WP4963,WP5166,WP4657,WP4595","p53 transcriptional gene network|Glyoxylate metabolism|22q11.2 copy number variation syndrome|Urea cycle and associated pathways","R-HSA-1430728,R-HSA-389661,R-HSA-70688,R-HSA-71291","Metabolism|Glyoxylate metabolism and glycine degradation|Proline catabolism|Metabolism of amino acids and derivatives"]
["ALDH5A1",0.172060948310062,0.104146323841687,0.0244752995117503,0.00500049889477423,0.122276884272579,0.0146885453483822,0.0437812666229306,0.076692013404365,0.125869083607047,0.205890503698694,0.0882618406747324,0.220318776231551,0.228088123223266,0.298252816672298,0.213354292576302,0.177970816807986,0.0250645726227646,0.0385944086196134,0.0433697449028642,0.0451247609661941,0.0541333404657979,0.0693849643042546,0.0411786751098022,0.0713146575643025,0.0775387361141485,0.0346794527962197,0.0201818447929932,0.0637225331425569,7915,"aldehyde dehydrogenase 5 family member A1","protein_coding","hsa00650,hsa00250","Butanoate metabolism|Alanine, aspartate and glutamate metabolism","GO:0004777,GO:0005739,GO:0005759,GO:0006105,GO:0006536,GO:0007417,GO:0009450,GO:0009791,GO:0042135,GO:0042802","succinate-semialdehyde dehydrogenase (NAD+) activity|mitochondrion|mitochondrial matrix|succinate metabolic process|glutamate metabolic process|central nervous system development|gamma-aminobutyric acid catabolic process|post-embryonic development|neurotransmitter catabolic process|identical protein binding","WP4157,WP4549","GABA metabolism (aka GHB)|Fragile X syndrome","R-HSA-112310,R-HSA-112315,R-HSA-112316,R-HSA-888590,R-HSA-916853","Neurotransmitter release cycle|Transmission across Chemical Synapses|Neuronal System|GABA synthesis, release, reuptake and degradation|Degradation of GABA"]
["ALDH6A1",7.24583065523335,7.06064025067597,6.29424642018038,5.15213180081541,7.84829200052711,6.63769924091412,6.56356641798971,5.90223553044755,8.23310608237281,6.8217360229493,6.53486309746302,7.42972732560206,9.14205405878631,7.94969685398713,8.07114547609649,9.35557868664453,8.94301277625827,7.49357614293663,6.71446749669288,8.74193860599189,8.14165440605601,8.08088572588718,8.49209515156068,8.50226478434436,8.63752572516798,7.03055335509253,7.52176458463979,7.01014963850888,4329,"aldehyde dehydrogenase 6 family member A1","protein_coding","hsa00640,hsa00562,hsa00280,hsa00410","Propanoate metabolism|Inositol phosphate metabolism|Valine, leucine and isoleucine degradation|beta-Alanine metabolism","GO:0003723,GO:0004491,GO:0005654,GO:0005739,GO:0005759,GO:0006210,GO:0006573,GO:0006574,GO:0009083,GO:0018478,GO:0019859,GO:0050873","RNA binding|methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity|nucleoplasm|mitochondrion|mitochondrial matrix|thymine catabolic process|valine metabolic process|valine catabolic process|branched-chain amino acid catabolic process|malonate-semialdehyde dehydrogenase (acetylating) activity|thymine metabolic process|brown fat cell differentiation","WP4686,WP4225","Leucine, isoleucine and valine metabolism|Pyrimidine metabolism and related diseases","R-HSA-1430728,R-HSA-70895,R-HSA-71291","Metabolism|Branched-chain amino acid catabolism|Metabolism of amino acids and derivatives"]
["ALDH7A1",18.651551234123,17.7837666869968,20.6443013294958,18.9024944873796,18.7838293875483,18.6887823790903,22.2733684602804,21.0799761502925,17.7025356571781,14.6293283472896,16.8597197961738,17.1030802963921,16.9358579294601,18.0462462053413,19.5870658285907,18.8752710940629,22.1910627104112,22.7850879309676,24.8507677555213,23.2778212834642,20.6050920468062,21.2833879577718,24.0706207730637,22.3064038749159,21.3183194818366,21.5495343655953,25.362426936364,21.8424837113118,501,"aldehyde dehydrogenase 7 family member A1","protein_coding","hsa00010,hsa00053,hsa00620,hsa00071,hsa00561,hsa00260,hsa00280,hsa00310,hsa00330,hsa00340,hsa00380,hsa00410,hsa04936","Glycolysis / Gluconeogenesis|Ascorbate and aldarate metabolism|Pyruvate metabolism|Fatty acid degradation|Glycerolipid metabolism|Glycine, serine and threonine metabolism|Valine, leucine and isoleucine degradation|Lysine degradation|Arginine and proline metabolism|Histidine metabolism|Tryptophan metabolism|beta-Alanine metabolism|Alcoholic liver disease","GO:0004029,GO:0004043,GO:0005515,GO:0005634,GO:0005739,GO:0005759,GO:0005829,GO:0006081,GO:0007605,GO:0008802,GO:0019285,GO:0042426,GO:0042802,GO:0043878,GO:0070062","aldehyde dehydrogenase (NAD+) activity|L-aminoadipate-semialdehyde dehydrogenase activity|protein binding|nucleus|mitochondrion|mitochondrial matrix|cytosol|cellular aldehyde metabolic process|sensory perception of sound|betaine-aldehyde dehydrogenase activity|glycine betaine biosynthetic process from choline|choline catabolic process|identical protein binding|glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity|extracellular exosome","WP5219,WP4288,WP5355,WP4519,WP4228,WP3925","Diet-dependent trimethylamine/trimethylamine N-oxide metabolism |MTHFR deficiency|Metabolic Epileptic Disorders|Cerebral organic acidurias, including diseases|Vitamin B6-dependent and responsive disorders|Amino acid metabolism","R-HSA-1430728,R-HSA-6798163,R-HSA-71064,R-HSA-71291","Metabolism|Choline catabolism|Lysine catabolism|Metabolism of amino acids and derivatives"]
["ALDH8A1",0.0212756237057956,0.0303549720521774,0.0699101096551101,0.0408091227876602,0.0519741097481942,0.00998944744161222,0.0496249119618852,0.0312942154144094,0.128402360348941,0.0819646104007737,0.0800339763725978,0.117727748377197,0.050582323747653,0.182553322280479,0.0692517386124738,0.151293923128336,0.0409104468696741,0.0295283779444655,0.0294950777621426,0.0306886364371512,0.0702836188368094,0.182009380374166,0.0840148975207882,0.0103928509304161,0.137105457885607,0.0202156692926436,0.020588030303823,0.0200015479537987,64577,"aldehyde dehydrogenase 8 family member A1","protein_coding","hsa00380","Tryptophan metabolism","GO:0001758,GO:0005829,GO:0042573,GO:0042574,GO:0042904,GO:0047102,GO:0070062,GO:0097053","retinal dehydrogenase activity|cytosol|retinoic acid metabolic process|retinal metabolic process|9-cis-retinoic acid biosynthetic process|aminomuconate-semialdehyde dehydrogenase activity|extracellular exosome|L-kynurenine catabolic process","WP465","Tryptophan metabolism","R-HSA-162582,R-HSA-5362517,R-HSA-5365859,R-HSA-9006931","Signal Transduction|Signaling by Retinoic Acid|RA biosynthesis pathway|Signaling by Nuclear Receptors"]
["ALDH9A1",33.3987827290408,31.5442099954281,32.4493191097145,30.8427521406294,33.4084551031436,31.7644790252737,33.5730801932345,33.0231412264602,25.3948026884835,19.4588549509891,22.0952539331069,25.0778471828911,26.3057193885767,23.2242363707648,26.9470784274135,26.4804382707261,24.3862098494895,23.7948946591412,27.5500159159019,25.3874126954859,23.6678345360352,25.5619417967609,28.1305802664112,26.0432157046762,21.7782942608023,24.4457840701628,28.3182359127035,25.2616062475305,223,"aldehyde dehydrogenase 9 family member A1","protein_coding","hsa00010,hsa00053,hsa00620,hsa00071,hsa00561,hsa00280,hsa00310,hsa00330,hsa00340,hsa00380,hsa00410,hsa04936","Glycolysis / Gluconeogenesis|Ascorbate and aldarate metabolism|Pyruvate metabolism|Fatty acid degradation|Glycerolipid metabolism|Valine, leucine and isoleucine degradation|Lysine degradation|Arginine and proline metabolism|Histidine metabolism|Tryptophan metabolism|beta-Alanine metabolism|Alcoholic liver disease","GO:0004029,GO:0005737,GO:0005829,GO:0006081,GO:0019145,GO:0033737,GO:0036094,GO:0042136,GO:0042445,GO:0043878,GO:0045329,GO:0047105,GO:0051289,GO:0070062","aldehyde dehydrogenase (NAD+) activity|cytoplasm|cytosol|cellular aldehyde metabolic process|aminobutyraldehyde dehydrogenase activity|1-pyrroline dehydrogenase activity|small molecule binding|neurotransmitter biosynthetic process|hormone metabolic process|glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity|carnitine biosynthetic process|4-trimethylammoniobutyraldehyde dehydrogenase activity|protein homotetramerization|extracellular exosome","WP4159,WP4966,WP5093","GABA receptor signaling|Fluoroacetic acid toxicity|Opioid receptor pathways","R-HSA-1430728,R-HSA-71262,R-HSA-71291","Metabolism|Carnitine synthesis|Metabolism of amino acids and derivatives"]
["ALDOA",4.12109424367796,5.30191715229195,5.46838696944456,6.43911826082099,4.44311980102216,4.2227975252413,5.93687357537174,5.10975982246084,4.46025169292028,5.24795367092639,4.77093801881424,4.14616321534268,4.45517449189877,5.88746717520539,4.25196664631327,4.51313334754452,6.20220054244812,6.10791936459762,6.42518471380801,5.31201472842285,5.46213454867256,5.75085927422322,5.26793318049085,4.63808017363321,4.78119508359377,6.23668427915447,5.21215835958449,6.39437033587473,226,"aldolase%2C fructose-bisphosphate A","protein_coding","hsa00010,hsa00030,hsa00051,hsa04066","Glycolysis / Gluconeogenesis|Pentose phosphate pathway|Fructose and mannose metabolism|HIF-1 signaling pathway","GO:0003723,GO:0003779,GO:0004332,GO:0005515,GO:0005576,GO:0005615,GO:0005634,GO:0005829,GO:0006000,GO:0006096,GO:0006754,GO:0006941,GO:0007015,GO:0007339,GO:0008092,GO:0008360,GO:0015629,GO:0015631,GO:0016020,GO:0030388,GO:0031093,GO:0031430,GO:0031674,GO:0034774,GO:0042802,GO:0045296,GO:0046716,GO:0051289,GO:0061827,GO:0070061,GO:0070062,GO:1904724,GO:1904813","RNA binding|actin binding|fructose-bisphosphate aldolase activity|protein binding|extracellular region|extracellular space|nucleus|cytosol|fructose metabolic process|glycolytic process|ATP biosynthetic process|striated muscle contraction|actin filament organization|binding of sperm to zona pellucida|cytoskeletal protein binding|regulation of cell shape|actin cytoskeleton|tubulin binding|membrane|fructose 1,6-bisphosphate metabolic process|platelet alpha granule lumen|M band|I band|secretory granule lumen|identical protein binding|cadherin binding|muscle cell cellular homeostasis|protein homotetramerization|sperm head|fructose binding|extracellular exosome|tertiary granule lumen|ficolin-1-rich granule lumen","WP4949,WP4629,WP4018,WP534,WP706,WP5355,WP1946,WP3888","16p11.2 proximal deletion syndrome|Aerobic glycolysis|Clear cell renal cell carcinoma pathways|Glycolysis and gluconeogenesis|Sudden infant death syndrome (SIDS) susceptibility pathways|Metabolic Epileptic Disorders|Cori cycle|VEGFA-VEGFR2 signaling","R-HSA-109582,R-HSA-114608,R-HSA-1430728,R-HSA-168249,R-HSA-168256,R-HSA-6798695,R-HSA-70171,R-HSA-70263,R-HSA-70326,R-HSA-71387,R-HSA-76002,R-HSA-76005","Hemostasis|Platelet degranulation |Metabolism|Innate Immune System|Immune System|Neutrophil degranulation|Glycolysis|Gluconeogenesis|Glucose metabolism|Metabolism of carbohydrates|Platelet activation, signaling and aggregation|Response to elevated platelet cytosolic Ca2+"]
["ALDOB",0,0,0,0.0106828840024722,0,0,0,0.0873824152728523,0,0,0,0.011206690998791,0.0105930254856655,0,0,0,0,0,0,0.010711433158642,0,0.0211759306642855,0.0109965780122767,0,0,0,0.0107789398326214,0,229,"aldolase%2C fructose-bisphosphate B","protein_coding","hsa00010,hsa00030,hsa00051,hsa04066","Glycolysis / Gluconeogenesis|Pentose phosphate pathway|Fructose and mannose metabolism|HIF-1 signaling pathway","GO:0004332,GO:0005515,GO:0005815,GO:0005829,GO:0006000,GO:0006094,GO:0006096,GO:0006116,GO:0008092,GO:0030388,GO:0032781,GO:0034451,GO:0042802,GO:0051117,GO:0060090,GO:0061609,GO:0061624,GO:0070061,GO:0070062,GO:0070072,GO:1905856","fructose-bisphosphate aldolase activity|protein binding|microtubule organizing center|cytosol|fructose metabolic process|gluconeogenesis|glycolytic process|NADH oxidation|cytoskeletal protein binding|fructose 1,6-bisphosphate metabolic process|positive regulation of ATP-dependent activity|centriolar satellite|identical protein binding|ATPase binding|molecular adaptor activity|fructose-1-phosphate aldolase activity|fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate|fructose binding|extracellular exosome|vacuolar proton-transporting V-type ATPase complex assembly|negative regulation of pentose-phosphate shunt","WP4018,WP534,WP690,WP5178,WP5355,WP4290","Clear cell renal cell carcinoma pathways|Glycolysis and gluconeogenesis|Polyol pathway|Disorders of fructose metabolism|Metabolic Epileptic Disorders|Metabolic reprogramming in colon cancer","R-HSA-1430728,R-HSA-1643685,R-HSA-5652084,R-HSA-5657560,R-HSA-5663084,R-HSA-5668914,R-HSA-70171,R-HSA-70263,R-HSA-70326,R-HSA-70350,R-HSA-71387","Metabolism|Disease|Fructose metabolism|Hereditary fructose intolerance|Diseases of carbohydrate metabolism|Diseases of metabolism|Glycolysis|Gluconeogenesis|Glucose metabolism|Fructose catabolism|Metabolism of carbohydrates"]
["ALDOC",17.8932159851671,19.2188040553911,20.9948471046119,22.5782169123983,18.6218238292646,25.0218002912302,20.7193521025029,23.87660356525,19.0440092578941,24.138801903442,20.5053659369652,19.4853194513004,20.7058582098219,25.9361759741815,19.2961577305732,23.8664523338355,23.4250580911592,23.8934273190486,17.4552334329228,23.0265596432694,22.7914764245522,25.5933736557672,16.9138385399191,21.6960725231619,21.878511910951,25.89342098853,17.375005639004,26.7279637441982,230,"aldolase%2C fructose-bisphosphate C","protein_coding","hsa00010,hsa00030,hsa00051,hsa04066","Glycolysis / Gluconeogenesis|Pentose phosphate pathway|Fructose and mannose metabolism|HIF-1 signaling pathway","GO:0004332,GO:0005515,GO:0005576,GO:0005829,GO:0005856,GO:0006000,GO:0006094,GO:0006096,GO:0008092,GO:0030388,GO:0030855,GO:0034774,GO:0070062,GO:1904724,GO:1904813","fructose-bisphosphate aldolase activity|protein binding|extracellular region|cytosol|cytoskeleton|fructose metabolic process|gluconeogenesis|glycolytic process|cytoskeletal protein binding|fructose 1,6-bisphosphate metabolic process|epithelial cell differentiation|secretory granule lumen|extracellular exosome|tertiary granule lumen|ficolin-1-rich granule lumen","WP4018,WP534,WP5049,WP5355","Clear cell renal cell carcinoma pathways|Glycolysis and gluconeogenesis|Glycolysis in senescence|Metabolic Epileptic Disorders","R-HSA-1430728,R-HSA-168249,R-HSA-168256,R-HSA-6798695,R-HSA-70171,R-HSA-70263,R-HSA-70326,R-HSA-71387","Metabolism|Innate Immune System|Immune System|Neutrophil degranulation|Glycolysis|Gluconeogenesis|Glucose metabolism|Metabolism of carbohydrates"]
["ALG1",9.88176994337968,9.41782730075788,11.0360132956331,10.4411869852346,8.20827996170346,9.24271084845143,10.5227691284711,9.9588448050312,9.18472239694878,9.81286567256144,10.7479865109083,9.94844823459265,8.65883649807705,8.88591188384009,8.75295025730406,8.68868179007124,9.22461237170695,9.55391502528151,11.3226771002,9.28912082348483,9.00658197764367,9.90172161298827,8.30569140918541,8.99104910492038,8.55459404792277,10.0344414876356,10.3582218904861,9.33909564984473,56052,"ALG1 chitobiosyldiphosphodolichol beta-mannosyltransferase","protein_coding","hsa00510,hsa00513","N-Glycan biosynthesis|Various types of N-glycan biosynthesis","GO:0000030,GO:0004578,GO:0005783,GO:0005789,GO:0006486,GO:0006488,GO:0016020","mannosyltransferase activity|chitobiosyldiphosphodolichol beta-mannosyltransferase activity|endoplasmic reticulum|endoplasmic reticulum membrane|protein glycosylation|dolichol-linked oligosaccharide biosynthetic process|membrane","WP4521,WP5153,WP4758","Glycosylation and related congenital defects|N-glycan biosynthesis|Nephrotic syndrome","R-HSA-1643685,R-HSA-3781860,R-HSA-3781865,R-HSA-392499,R-HSA-446193,R-HSA-446203,R-HSA-4549380,R-HSA-5668914,R-HSA-597592","Disease|Diseases associated with N-glycosylation of proteins|Diseases of glycosylation|Metabolism of proteins|Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein|Asparagine N-linked glycosylation|Defective ALG1 causes CDG-1k|Diseases of metabolism|Post-translational protein modification"]
["ALG10",0.796253266516994,0.646657222417923,0.288092769836838,0.367872816140088,0.46528814403035,0.467015980922917,0.318384474417523,0.355382310593246,0.526852903684946,0.346503580652063,0.320927212960414,0.292759680459095,0.349684191645551,0.229504420444579,0.307521214152545,0.421378073947073,0.445086792550466,0.423444860322233,0.469420385785401,0.531661301568005,0.441938429180542,0.510445912568051,0.697284486442834,0.625435445569897,0.430118047605261,0.452442152981383,0.514533063138734,0.31584191164846,84920,"ALG10 alpha-1%2C2-glucosyltransferase","protein_coding","hsa00510","N-Glycan biosynthesis","GO:0005515,GO:0005783,GO:0005789,GO:0006487,GO:0006488,GO:0106073","protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|protein N-linked glycosylation|dolichol-linked oligosaccharide biosynthetic process|dolichyl pyrophosphate Glc2Man9GlcNAc2 alpha-1,2-glucosyltransferase activity","WP5153","N-glycan biosynthesis","R-HSA-392499,R-HSA-446193,R-HSA-446203,R-HSA-597592","Metabolism of proteins|Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein|Asparagine N-linked glycosylation|Post-translational protein modification"]
["ALG10B",0.491562328094625,0.4422839611151,0.239479165178352,0.341473201017416,0.402442012534219,0.384252539361753,0.260299661423338,0.330903296081301,0.526517179903655,0.291739881642852,0.272373884647237,0.24326638657011,0.538223845918299,0.253321350779658,0.348422596575444,0.365302619845865,0.268236633775608,0.221266366815009,0.189092182776203,0.426704642359152,0.368661655276685,0.368747157333925,0.451179460998527,0.44909204303378,0.413585784238496,0.265095274947939,0.383111890078524,0.257291474570595,144245,"ALG10 alpha-1%2C2-glucosyltransferase B","protein_coding","hsa00510","N-Glycan biosynthesis","GO:0005515,GO:0005783,GO:0005886,GO:0006486,GO:0006487,GO:0006488,GO:0016740,GO:0060050,GO:0106073,GO:1901980","protein binding|endoplasmic reticulum|plasma membrane|protein glycosylation|protein N-linked glycosylation|dolichol-linked oligosaccharide biosynthetic process|transferase activity|positive regulation of protein glycosylation|dolichyl pyrophosphate Glc2Man9GlcNAc2 alpha-1,2-glucosyltransferase activity|positive regulation of inward rectifier potassium channel activity","WP5153","N-glycan biosynthesis","R-HSA-392499,R-HSA-446193,R-HSA-446203,R-HSA-597592","Metabolism of proteins|Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein|Asparagine N-linked glycosylation|Post-translational protein modification"]
["ALG11",1.27120707791392,0.799521676066778,0.715295327789182,0.516257343652498,1.16933922873905,0.664910511323311,0.602670543722921,0.674025803828921,1.03292565436259,0.59820945494113,0.385518500704457,0.733203353334114,1.41367260851559,0.730322341285764,0.870295428473687,0.859804991954711,1.01915401406087,0.482741352975971,0.746257182519587,0.828219200419979,0.945795106694294,0.806864762100771,1.09144837432449,1.1812536717728,1.10430564747598,0.649183831639571,0.849466557869137,0.657878871353495,440138,"ALG11 alpha-1%2C2-mannosyltransferase","protein_coding","hsa00510,hsa00513","N-Glycan biosynthesis|Various types of N-glycan biosynthesis","GO:0000026,GO:0004377,GO:0005789,GO:0006487,GO:0006490,GO:0016020","alpha-1,2-mannosyltransferase activity|GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity|endoplasmic reticulum membrane|protein N-linked glycosylation|oligosaccharide-lipid intermediate biosynthetic process|membrane","WP4521,WP5153","Glycosylation and related congenital defects|N-glycan biosynthesis","R-HSA-1643685,R-HSA-3781860,R-HSA-3781865,R-HSA-392499,R-HSA-446193,R-HSA-446203,R-HSA-4551295,R-HSA-5668914,R-HSA-597592","Disease|Diseases associated with N-glycosylation of proteins|Diseases of glycosylation|Metabolism of proteins|Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein|Asparagine N-linked glycosylation|Defective ALG11 causes CDG-1p|Diseases of metabolism|Post-translational protein modification"]
["ALG12",5.03144202999005,5.76484469230753,5.62237461107451,5.98336818949316,4.94941545286674,6.5767498739504,5.63673825127552,5.11305635119932,5.20126174322708,7.12526812094156,7.09314683103496,5.57502880693605,5.16453468440857,5.34717343124042,5.71704984738052,5.35891138970335,5.19352793848091,5.61231329680695,5.01026492889166,4.64406761543351,4.8124964703891,5.28094609205428,4.77719291621126,4.61951838424234,4.70215336652636,5.8914138310103,4.10080572839855,5.34062388384437,79087,"ALG12 alpha-1%2C6-mannosyltransferase","protein_coding","hsa00510,hsa00513","N-Glycan biosynthesis|Various types of N-glycan biosynthesis","GO:0000009,GO:0000030,GO:0005783,GO:0005789,GO:0006457,GO:0006487,GO:0006488,GO:0016020,GO:0052917","alpha-1,6-mannosyltransferase activity|mannosyltransferase activity|endoplasmic reticulum|endoplasmic reticulum membrane|protein folding|protein N-linked glycosylation|dolichol-linked oligosaccharide biosynthetic process|membrane|dolichyl-P-Man:Man(7)GlcNAc(2)-PP-dolichol alpha-1,6-mannosyltransferase","WP4521,WP5153","Glycosylation and related congenital defects|N-glycan biosynthesis","R-HSA-1643685,R-HSA-3781860,R-HSA-3781865,R-HSA-392499,R-HSA-446193,R-HSA-446203,R-HSA-4720489,R-HSA-5668914,R-HSA-597592","Disease|Diseases associated with N-glycosylation of proteins|Diseases of glycosylation|Metabolism of proteins|Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein|Asparagine N-linked glycosylation|Defective ALG12 causes CDG-1g|Diseases of metabolism|Post-translational protein modification"]
["ALG13",2.14139196429949,2.28402633192735,2.10426261494901,1.98767667687036,2.55699085705919,1.9941884124512,2.00618940338281,2.07370316854355,2.69467193267276,2.22075462526032,2.03056783515218,2.39801946839067,2.3385314952261,2.6091243244406,2.56372390257478,2.61377883421584,2.12716118826294,2.032738242122,2.02633979391921,2.30058810866873,2.30210561852325,1.88977949014322,2.49121652617306,2.55867622083216,2.43355126279199,1.97771883437753,2.40536905545464,2.02777456786127,79868,"ALG13 UDP-N-acetylglucosaminyltransferase subunit","protein_coding","hsa00510,hsa00513","N-Glycan biosynthesis|Various types of N-glycan biosynthesis","GO:0003723,GO:0004577,GO:0004843,GO:0005789,GO:0006488,GO:0006508","RNA binding|N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity|cysteine-type deubiquitinase activity|endoplasmic reticulum membrane|dolichol-linked oligosaccharide biosynthetic process|proteolysis","WP4521,WP5153","Glycosylation and related congenital defects|N-glycan biosynthesis","R-HSA-1643685,R-HSA-3781860,R-HSA-3781865,R-HSA-392499,R-HSA-446193,R-HSA-446203,R-HSA-5633231,R-HSA-5668914,R-HSA-597592","Disease|Diseases associated with N-glycosylation of proteins|Diseases of glycosylation|Metabolism of proteins|Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein|Asparagine N-linked glycosylation|Defective ALG14 causes ALG14-CMS|Diseases of metabolism|Post-translational protein modification"]
["ALG14",0.931188390979402,0.809992936299051,0.982945901887869,0.969413882300589,0.832127172328249,0.833656668397413,1.10511934335969,1.01720670007305,0.905104108938409,0.741182264173794,0.85757902649505,0.902873769890071,0.773137283388192,0.793476875570587,0.973689113113346,0.761679737497755,1.54006926911108,1.24775146257988,1.60085014084408,1.22486493939381,1.39349508247557,1.22679780879946,1.586128934486,1.37640261378932,1.17433181471083,1.16215493716182,1.5080483460832,1.39024720340297,199857,"ALG14 UDP-N-acetylglucosaminyltransferase subunit","protein_coding","hsa00510,hsa00513","N-Glycan biosynthesis|Various types of N-glycan biosynthesis","GO:0004577,GO:0005789,GO:0006488,GO:0031965,GO:0043541","N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity|endoplasmic reticulum membrane|dolichol-linked oligosaccharide biosynthetic process|nuclear membrane|UDP-N-acetylglucosamine transferase complex","WP4521,WP5153","Glycosylation and related congenital defects|N-glycan biosynthesis","R-HSA-1643685,R-HSA-3781860,R-HSA-3781865,R-HSA-392499,R-HSA-446193,R-HSA-446203,R-HSA-5633231,R-HSA-5668914,R-HSA-597592","Disease|Diseases associated with N-glycosylation of proteins|Diseases of glycosylation|Metabolism of proteins|Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein|Asparagine N-linked glycosylation|Defective ALG14 causes ALG14-CMS|Diseases of metabolism|Post-translational protein modification"]
["ALG14-AS1",0,0,0,0.0235881197864806,0,0,0.0458939879238749,0,0,0,0,0,0,0,0,0,0.0472933724305448,0,0,0.0236511571568556,0,0,0,0,0,0.0233697563811856,0,0,101928098,"ALG14 antisense RNA 1","non_coding"]
["ALG1L2",0,0.0188113228613885,0,0.0948370480043389,0,0.0371434480074033,0.0184518748219247,0,0.139251716059521,0,0,0,0.018807866232803,0,0,0.0187517144146345,0,0,0,0,0,0,0,0,0,0,0,0,644974,"ALG1 chitobiosyldiphosphodolichol beta-mannosyltransferase like 2","protein_coding",null,null,"GO:0000030,GO:0005783,GO:0006486","mannosyltransferase activity|endoplasmic reticulum|protein glycosylation"]
["ALG2",12.2205348983135,11.943341040803,11.8335806907876,11.720204213339,13.4422742698046,12.278012774507,12.1360832596132,11.4562609738554,12.2246089061983,12.4356412084325,11.3572858319635,11.0682835757718,14.3238981155848,12.3646575322085,13.9183663461034,14.7089302647398,11.2416750484263,11.3338775868456,12.2349462014414,12.4346464118774,10.4652008090663,11.4426946702802,11.6947510635689,10.6542414945578,9.96477690404855,11.1829943626686,12.1878793184352,10.7757484834084,85365,"ALG2 alpha-1%2C3/1%2C6-mannosyltransferase","protein_coding","hsa00510,hsa00513","N-Glycan biosynthesis|Various types of N-glycan biosynthesis","GO:0000033,GO:0004378,GO:0005515,GO:0005634,GO:0005737,GO:0005789,GO:0006486,GO:0006488,GO:0006490,GO:0016020,GO:0046982,GO:0048306,GO:0048471,GO:0051592,GO:0102704","alpha-1,3-mannosyltransferase activity|GDP-Man:Man1GlcNAc2-PP-Dol alpha-1,3-mannosyltransferase activity|protein binding|nucleus|cytoplasm|endoplasmic reticulum membrane|protein glycosylation|dolichol-linked oligosaccharide biosynthetic process|oligosaccharide-lipid intermediate biosynthetic process|membrane|protein heterodimerization activity|calcium-dependent protein binding|perinuclear region of cytoplasm|response to calcium ion|GDP-Man:Man2GlcNAc2-PP-dolichol alpha-1,6-mannosyltransferase activity","WP4521,WP5153","Glycosylation and related congenital defects|N-glycan biosynthesis","R-HSA-1643685,R-HSA-3781860,R-HSA-3781865,R-HSA-392499,R-HSA-392499,R-HSA-446193,R-HSA-446193,R-HSA-446203,R-HSA-446203,R-HSA-4549349,R-HSA-5668914,R-HSA-597592,R-HSA-597592","Disease|Diseases associated with N-glycosylation of proteins|Diseases of glycosylation|Metabolism of proteins|Metabolism of proteins|Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein|Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein|Asparagine N-linked glycosylation|Asparagine N-linked glycosylation|Defective ALG2 causes CDG-1i|Diseases of metabolism|Post-translational protein modification|Post-translational protein modification"]
["ALG3",13.594549152115,15.5057305762857,16.3979220486932,17.365339433997,12.8857849952854,15.4039113465497,14.4761334435821,15.8855993683056,12.2541402718219,19.4717177583338,18.2054608430383,15.5809311657489,10.9765936763073,13.5990615636416,12.6293184176072,12.6136869799634,12.7904568229113,14.3966573940521,14.9588671848069,13.6746597593432,12.6663832383633,15.3571233667396,11.5097120683355,10.2526372299046,12.2225108011697,15.3790158364377,13.3805522004301,14.0940713256948,10195,"ALG3 alpha-1%2C3- mannosyltransferase","protein_coding","hsa00510,hsa00513","N-Glycan biosynthesis|Various types of N-glycan biosynthesis","GO:0000033,GO:0005515,GO:0005783,GO:0005789,GO:0006486,GO:0006488,GO:0052925","alpha-1,3-mannosyltransferase activity|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|protein glycosylation|dolichol-linked oligosaccharide biosynthetic process|dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity","WP4521,WP5153","Glycosylation and related congenital defects|N-glycan biosynthesis","R-HSA-1643685,R-HSA-3781860,R-HSA-3781865,R-HSA-392499,R-HSA-446193,R-HSA-446203,R-HSA-4720475,R-HSA-5668914,R-HSA-597592","Disease|Diseases associated with N-glycosylation of proteins|Diseases of glycosylation|Metabolism of proteins|Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein|Asparagine N-linked glycosylation|Defective ALG3 causes CDG-1d|Diseases of metabolism|Post-translational protein modification"]
["ALG5",26.9778494368765,18.7257207742102,19.1532379554786,21.9726175472357,19.3642685389025,17.9590061623339,21.0928179169231,20.1749235711524,19.1932674258668,14.4813738277602,20.284678755997,20.2421980432416,18.701705941298,17.7586094241648,17.9065209840825,17.9484457494009,22.7759719588063,22.0391186709776,24.4936184150227,18.4738695028855,21.1545795662972,21.7362600655708,24.6040931346272,24.6446024433776,24.7731905775934,22.0775551487312,23.4681569476179,23.3284346406983,29880,"ALG5 dolichyl-phosphate beta-glucosyltransferase","protein_coding","hsa00510","N-Glycan biosynthesis","GO:0004576,GO:0004581,GO:0005515,GO:0005789,GO:0006486,GO:0006487,GO:0007368,GO:0016020,GO:0018279","oligosaccharyl transferase activity|dolichyl-phosphate beta-glucosyltransferase activity|protein binding|endoplasmic reticulum membrane|protein glycosylation|protein N-linked glycosylation|determination of left/right symmetry|membrane|protein N-linked glycosylation via asparagine","WP5153","N-glycan biosynthesis","R-HSA-392499,R-HSA-446193,R-HSA-446203,R-HSA-446219,R-HSA-480985,R-HSA-597592","Metabolism of proteins|Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein|Asparagine N-linked glycosylation|Synthesis of substrates in N-glycan biosythesis|Synthesis of dolichyl-phosphate-glucose|Post-translational protein modification"]
["ALG6",2.4888896472841,2.04347541681781,2.01698550953826,1.98267901290995,2.31320896708342,1.88041358640908,2.27672827671197,2.01925650450815,1.81849279675941,1.35862812629577,1.50960928696903,1.66391555256636,2.44401009656344,1.576748274125,1.97537199908615,1.91401145865852,2.63454665115044,2.66294164887246,2.93717158930462,3.00925231342878,3.39745728974517,2.32725070175735,4.21785738411338,2.90680382633581,2.59614457793238,2.31867342891056,3.82057496250755,2.36270916986873,29929,"ALG6 alpha-1%2C3-glucosyltransferase","protein_coding","hsa00510","N-Glycan biosynthesis","GO:0004583,GO:0005789,GO:0006487,GO:0006488,GO:0006490,GO:0016020,GO:0042281,GO:0046527","dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity|endoplasmic reticulum membrane|protein N-linked glycosylation|dolichol-linked oligosaccharide biosynthetic process|oligosaccharide-lipid intermediate biosynthetic process|membrane|dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity|glucosyltransferase activity","WP4521,WP5153,WP117","Glycosylation and related congenital defects|N-glycan biosynthesis|GPCRs, other","R-HSA-1643685,R-HSA-3781860,R-HSA-3781865,R-HSA-392499,R-HSA-446193,R-HSA-446203,R-HSA-4724289,R-HSA-5668914,R-HSA-597592","Disease|Diseases associated with N-glycosylation of proteins|Diseases of glycosylation|Metabolism of proteins|Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein|Asparagine N-linked glycosylation|Defective ALG6 causes CDG-1c|Diseases of metabolism|Post-translational protein modification"]
["ALG8",13.6176103238549,13.3200565857462,15.3638041541017,14.5420758483653,13.5896737863132,12.626399104601,13.946583677357,13.3639089918184,13.6111187565565,11.8339261323207,13.613924346979,13.7112436766259,13.1339178328521,11.8164275267789,13.2231673668284,11.7516591134373,20.0978758929523,17.0580141831172,21.9381695638248,17.6973172923217,16.1042377906412,15.7694930161036,20.3613549019992,19.615322868674,18.7351736442561,17.3440061076508,20.9033336930819,20.0052186200434,79053,"ALG8 alpha-1%2C3-glucosyltransferase","protein_coding","hsa00510","N-Glycan biosynthesis","GO:0000033,GO:0004583,GO:0005515,GO:0005789,GO:0006487,GO:0006488,GO:0006490,GO:0018279,GO:0042283","alpha-1,3-mannosyltransferase activity|dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity|protein binding|endoplasmic reticulum membrane|protein N-linked glycosylation|dolichol-linked oligosaccharide biosynthetic process|oligosaccharide-lipid intermediate biosynthetic process|protein N-linked glycosylation via asparagine|dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity","WP4521,WP5153","Glycosylation and related congenital defects|N-glycan biosynthesis","R-HSA-1643685,R-HSA-3781860,R-HSA-3781865,R-HSA-392499,R-HSA-446193,R-HSA-446203,R-HSA-4724325,R-HSA-5668914,R-HSA-597592","Disease|Diseases associated with N-glycosylation of proteins|Diseases of glycosylation|Metabolism of proteins|Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein|Asparagine N-linked glycosylation|Defective ALG8 causes CDG-1h|Diseases of metabolism|Post-translational protein modification"]
["ALG9",4.94683391774322,4.69065852536919,4.4641148294833,4.22533613614866,4.38382968978216,3.79843050215914,4.07110512808318,3.99658852768795,4.93724198293796,4.00301259154812,4.64860214644564,4.58309626447426,4.42337236196987,4.07225071237638,4.21149952529958,4.16273109890889,4.45352207957999,4.56647844953969,4.11087086418485,4.72376642258109,4.17645195498584,4.58176713928737,3.61819354273529,4.47673237523682,4.42880418836951,3.97472177722374,3.77683371008796,4.01921196480834,79796,"ALG9 alpha-1%2C2-mannosyltransferase","protein_coding","hsa00510,hsa00513","N-Glycan biosynthesis|Various types of N-glycan biosynthesis","GO:0000026,GO:0005789,GO:0006487,GO:0006488,GO:0016020,GO:0052918,GO:0052926","alpha-1,2-mannosyltransferase activity|endoplasmic reticulum membrane|protein N-linked glycosylation|dolichol-linked oligosaccharide biosynthetic process|membrane|dol-P-Man:Man(8)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity|dol-P-Man:Man(6)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity","WP4521,WP5153","Glycosylation and related congenital defects|N-glycan biosynthesis","R-HSA-1643685,R-HSA-3781860,R-HSA-3781865,R-HSA-392499,R-HSA-446193,R-HSA-446203,R-HSA-4720454,R-HSA-5668914,R-HSA-597592","Disease|Diseases associated with N-glycosylation of proteins|Diseases of glycosylation|Metabolism of proteins|Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein|Asparagine N-linked glycosylation|Defective ALG9 causes CDG-1l|Diseases of metabolism|Post-translational protein modification"]
["ALK",0,0,0,0,0,0,0,0,0.00295620349182492,0.00849180887847091,0.00276392956999785,0.0177410764612348,0.019564528099343,0.00840583876033461,0.00273322387458738,0.0167195290539556,0.00282563978324668,0.00271932365573759,0,0,0.00277395006747983,0.00279359748187804,0.0116056340120844,0.0028712913495066,0.0116550447945965,0.0139627414924659,0.0142199271668904,0,238,"ALK receptor tyrosine kinase","protein_coding","hsa05200,hsa05235,hsa05223","Pathways in cancer|PD-L1 expression and PD-1 checkpoint pathway in cancer|Non-small cell lung cancer","GO:0004704,GO:0004713,GO:0004714,GO:0005515,GO:0005524,GO:0005886,GO:0007165,GO:0007169,GO:0007275,GO:0008201,GO:0016310,GO:0021766,GO:0030298,GO:0030534,GO:0032991,GO:0033674,GO:0036269,GO:0038061,GO:0038083,GO:0042127,GO:0042802,GO:0042981,GO:0043235,GO:0045664,GO:0046777,GO:0048666,GO:0050995,GO:0051092,GO:0060159,GO:0070062,GO:0090648,GO:0097009,GO:1900006","NF-kappaB-inducing kinase activity|protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity|protein binding|ATP binding|plasma membrane|signal transduction|transmembrane receptor protein tyrosine kinase signaling pathway|multicellular organism development|heparin binding|phosphorylation|hippocampus development|receptor signaling protein tyrosine kinase activator activity|adult behavior|protein-containing complex|positive regulation of kinase activity|swimming behavior|non-canonical NF-kappaB signal transduction|peptidyl-tyrosine autophosphorylation|regulation of cell population proliferation|identical protein binding|regulation of apoptotic process|receptor complex|regulation of neuron differentiation|protein autophosphorylation|neuron development|negative regulation of lipid catabolic process|positive regulation of NF-kappaB transcription factor activity|regulation of dopamine receptor signaling pathway|extracellular exosome|response to environmental enrichment|energy homeostasis|positive regulation of dendrite development","WP4205,WP2848,WP4928,WP4255","MET in type 1 papillary renal cell carcinoma|Pluripotent stem cell differentiation pathway|MAPK pathway in congenital thyroid cancer|Non-small cell lung cancer","R-HSA-162582,R-HSA-162582,R-HSA-1643685,R-HSA-201556,R-HSA-201556,R-HSA-5663202,R-HSA-9006934,R-HSA-9006934,R-HSA-9700206,R-HSA-9700645,R-HSA-9700649,R-HSA-9717264,R-HSA-9717301,R-HSA-9717316,R-HSA-9717319,R-HSA-9717323,R-HSA-9717326,R-HSA-9717329,R-HSA-9725370,R-HSA-9725371","Signal Transduction|Signal Transduction|Disease|Signaling by ALK|Signaling by ALK|Diseases of signal transduction by growth factor receptors and second messengers|Signaling by Receptor Tyrosine Kinases|Signaling by Receptor Tyrosine Kinases|Signaling by ALK in cancer|ALK mutants bind TKIs|Drug resistance of ALK mutants|ASP-3026-resistant ALK mutants|NVP-TAE684-resistant ALK mutants|alectinib-resistant ALK mutants|brigatinib-resistant ALK mutants|ceritinib-resistant ALK mutants|crizotinib-resistant ALK mutants|lorlatinib-resistant ALK mutants|Signaling by ALK fusions and activated point mutants|Nuclear events stimulated by ALK signaling in cancer"]
["ALKAL2",0.0358460308979296,0,0,0,0,0,0,0,0,0.103572966799647,0,0,0,0,0,0,0,0,0,0,0,0.0170364867711339,0.0707758478449725,0,0,0,0,0,285016,"ALK and LTK ligand 2","protein_coding",null,null,"GO:0005125,GO:0005515,GO:0005576,GO:0005615,GO:0005886,GO:0007169,GO:0010976,GO:0030297,GO:0030298,GO:0030971,GO:0070374,GO:0070378","cytokine activity|protein binding|extracellular region|extracellular space|plasma membrane|transmembrane receptor protein tyrosine kinase signaling pathway|positive regulation of neuron projection development|transmembrane receptor protein tyrosine kinase activator activity|receptor signaling protein tyrosine kinase activator activity|receptor tyrosine kinase binding|positive regulation of ERK1 and ERK2 cascade|positive regulation of ERK5 cascade"]
["ALKBH1",4.01696391838239,4.08736653325761,3.72254509185493,3.46426553389372,3.86435211034525,3.33351361472064,3.86400163555298,4.04080581677128,3.29923692835493,3.98881549766406,3.67034521294711,3.61324085756939,2.93170240183567,3.13697573300001,3.40754819804912,3.0016823095417,2.96391225387206,3.61111103214473,3.90442748158806,3.56335601196658,3.77182439633659,3.95640096943318,3.63772051226297,3.58981957151205,3.74582458525205,3.85628876417703,4.22864824038172,3.65931285003798,8846,"alkB homolog 1%2C histone H2A dioxygenase","protein_coding",null,null,"GO:0000049,GO:0000791,GO:0001701,GO:0001764,GO:0001890,GO:0002101,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005783,GO:0006281,GO:0006307,GO:0006446,GO:0006448,GO:0008198,GO:0016706,GO:0031175,GO:0035513,GO:0035515,GO:0035516,GO:0035552,GO:0042056,GO:0042245,GO:0043524,GO:0048589,GO:0050918,GO:0070129,GO:0070579,GO:0070989,GO:0080111,GO:0140078,GO:1990983,GO:1990984","tRNA binding|euchromatin|in utero embryonic development|neuron migration|placenta development|tRNA wobble cytosine modification|nucleus|nucleoplasm|cytoplasm|mitochondrion|endoplasmic reticulum|DNA repair|DNA dealkylation involved in DNA repair|regulation of translational initiation|regulation of translational elongation|ferrous iron binding|2-oxoglutarate-dependent dioxygenase activity|neuron projection development|oxidative RNA demethylation|oxidative RNA demethylase activity|oxidative DNA demethylase activity|oxidative single-stranded DNA demethylation|chemoattractant activity|RNA repair|negative regulation of neuron apoptotic process|developmental growth|positive chemotaxis|regulation of mitochondrial translation|methylcytosine dioxygenase activity|oxidative demethylation|DNA demethylation|class I DNA-(apurinic or apyrimidinic site) endonuclease activity|tRNA demethylation|tRNA demethylase activity"]
["ALKBH2",7.65000880462463,8.54022818879189,10.8487541934399,9.86607021294787,8.16377797644489,9.527918556976,10.2928664297918,9.92971609550338,9.01109992533465,8.47312985849327,10.4886647922892,8.85102613805936,6.4135666626057,8.36815582670351,9.15519362636511,7.73056581971209,7.16146691114061,7.3390625905508,8.31690704282385,6.02064139197698,7.33448142442498,7.0802570264381,7.29387662122737,8.00488580498398,7.02554610555001,7.24975570174937,7.81187363134612,7.94893482310267,121642,"alkB homolog 2%2C alpha-ketoglutarate dependent dioxygenase","protein_coding",null,null,"GO:0000182,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0006307,GO:0008198,GO:0035516,GO:0043734,GO:0051747,GO:0070989,GO:0080111","rDNA binding|protein binding|nucleus|nucleoplasm|nucleolus|DNA dealkylation involved in DNA repair|ferrous iron binding|oxidative DNA demethylase activity|DNA-N1-methyladenine dioxygenase activity|cytosine C-5 DNA demethylase activity|oxidative demethylation|DNA demethylation","WP4931","Direct reversal repair","R-HSA-112122,R-HSA-73894,R-HSA-73942,R-HSA-73943","ALKBH2 mediated reversal of alkylation damage|DNA Repair|DNA Damage Reversal|Reversal of alkylation damage by DNA dioxygenases"]
["ALKBH3",13.9320335218419,12.7036737635722,16.6367043980421,14.9020696661429,11.4813097448957,13.9026193813824,16.3376652191906,14.6204250320675,12.6615344338601,13.5528536383566,16.1726040063342,13.5600961085371,11.871186527103,13.2159094061253,13.6873549646464,13.5076468819118,13.2101661194013,16.1539096958712,15.7807071360504,13.9177869003915,13.9407375880897,15.7321804056921,14.1676378530708,15.0610314763773,13.3625088570049,16.1078164876683,15.4584238804233,14.3943652997377,221120,"alkB homolog 3%2C alpha-ketoglutarate dependent dioxygenase","protein_coding",null,null,"GO:0005515,GO:0005634,GO:0005654,GO:0005739,GO:0005829,GO:0006281,GO:0006307,GO:0008198,GO:0008283,GO:0031418,GO:0035515,GO:0035516,GO:0035552,GO:0035553,GO:0043734,GO:1990930","protein binding|nucleus|nucleoplasm|mitochondrion|cytosol|DNA repair|DNA dealkylation involved in DNA repair|ferrous iron binding|cell population proliferation|L-ascorbic acid binding|oxidative RNA demethylase activity|oxidative DNA demethylase activity|oxidative single-stranded DNA demethylation|oxidative single-stranded RNA demethylation|DNA-N1-methyladenine dioxygenase activity|mRNA N1-methyladenosine dioxygenase activity","WP5348,WP4931","11p11.2 copy number variation syndrome |Direct reversal repair","R-HSA-112126,R-HSA-73894,R-HSA-73942,R-HSA-73943","ALKBH3 mediated reversal of alkylation damage|DNA Repair|DNA Damage Reversal|Reversal of alkylation damage by DNA dioxygenases"]
["ALKBH3-AS1",0,0.0133055698287869,0,0,0.0136691638922599,0,0,0,0,0,0,0,0,0,0,0,0,0,0.0129286502420462,0,0,0,0.0138099215307263,0.0136665720070963,0.0138687170285468,0,0,0,100507300,"ALKBH3 antisense RNA 1","non_coding"]
["ALKBH4",5.13573389789939,5.52896874044218,6.21292138487565,6.40800898889525,5.48031763135021,5.27859446421799,5.51867592037784,5.54971517283258,5.07589946856501,6.20141911545038,6.1995228437282,5.55257016008346,4.76254393209561,5.56618441882679,6.13064964876834,4.9905866065519,4.77802027856119,6.61958126987588,7.49766740541644,5.17204849795625,6.35463843600639,6.81252772238087,5.65026067193835,5.64153501633598,4.76237282486621,6.45793866952164,5.62497187189546,6.65376613110641,54784,"alkB homolog 4%2C lysine demethylase","protein_coding",null,null,"GO:0003779,GO:0005515,GO:0005730,GO:0005737,GO:0006325,GO:0006482,GO:0016491,GO:0016706,GO:0030496,GO:0031032,GO:0032451,GO:0035516,GO:0036090,GO:0046872,GO:0070938,GO:0080111,GO:1902275","actin binding|protein binding|nucleolus|cytoplasm|chromatin organization|protein demethylation|oxidoreductase activity|2-oxoglutarate-dependent dioxygenase activity|midbody|actomyosin structure organization|demethylase activity|oxidative DNA demethylase activity|cleavage furrow ingression|metal ion binding|contractile ring|DNA demethylation|regulation of chromatin organization"]
["ALKBH5",30.9497286034272,30.8505873571812,30.3385089792759,33.3734784198283,26.6489934504431,31.3871600833702,32.0523960332615,30.1483854935094,26.5907238135176,29.2661335601674,31.7065086183274,29.7128791590042,26.4466165051716,31.6138229592318,29.2512854973913,29.3935883673266,34.2029142688483,38.0875133952931,34.0618694023208,33.3395815368856,33.9477221050234,37.8219282279049,28.2122970011831,32.3128638755133,34.542021945648,35.6753128118485,30.494470408524,35.4659103258132,54890,"alkB homolog 5%2C RNA demethylase","protein_coding",null,null,"GO:0001666,GO:0003723,GO:0005634,GO:0005654,GO:0005794,GO:0005829,GO:0006397,GO:0006406,GO:0007283,GO:0016607,GO:0016706,GO:0030154,GO:0035515,GO:0035553,GO:0043488,GO:0046872,GO:1990931","response to hypoxia|RNA binding|nucleus|nucleoplasm|Golgi apparatus|cytosol|mRNA processing|mRNA export from nucleus|spermatogenesis|nuclear speck|2-oxoglutarate-dependent dioxygenase activity|cell differentiation|oxidative RNA demethylase activity|oxidative single-stranded RNA demethylation|regulation of mRNA stability|metal ion binding|mRNA N6-methyladenosine dioxygenase activity","WP5381","Smith-Magenis and Potocki-Lupski syndrome copy number variation","R-HSA-73894,R-HSA-73942,R-HSA-73943","DNA Repair|DNA Damage Reversal|Reversal of alkylation damage by DNA dioxygenases"]
["ALKBH6",8.54640919620493,7.66263202159132,7.66852858745965,9.39238717302597,7.05059594204688,8.63071644489696,6.81034340133559,7.89972913540631,6.80675994815477,9.89103888902195,8.85432020517967,8.21781292232554,5.62267221776562,6.65193691071984,5.58973830719332,6.24352171058162,7.63763383998398,8.45215542823141,8.96057600798586,8.86510275701416,9.25668867632407,8.96267963505593,7.39982824973735,7.40514396226713,8.09806929691671,9.94443866234577,7.52452915238763,10.1947390921395,84964,"alkB homolog 6","protein_coding",null,null,"GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005925,GO:0046872,GO:0051213","protein binding|nucleus|nucleoplasm|cytoplasm|focal adhesion|metal ion binding|dioxygenase activity"]
["ALKBH7",23.4651969266317,23.5456303598017,32.1976437181119,28.0402515581593,22.0763836471069,28.3679872710523,34.4770226101501,32.5211758621804,29.4286903457335,30.7382819457042,37.8302762093372,32.8475617287008,31.3318153809351,38.9935747148356,33.8128875271174,33.6643637066909,30.0359895105248,35.6230438434108,43.3740708851045,31.4340759867328,35.290237664219,36.1812356461841,36.0501650418362,34.1062930783718,33.9224838533237,39.8428379903236,43.0143944658344,38.3579207554094,84266,"alkB homolog 7","protein_coding",null,null,"GO:0005515,GO:0005739,GO:0005759,GO:0006631,GO:0006974,GO:0010883,GO:0046872,GO:0051213,GO:1902445","protein binding|mitochondrion|mitochondrial matrix|fatty acid metabolic process|DNA damage response|regulation of lipid storage|metal ion binding|dioxygenase activity|regulation of mitochondrial membrane permeability involved in programmed necrotic cell death"]
["ALKBH8",2.6796237696755,2.10857465606361,2.21534142732024,1.86853105903351,2.08244989402364,1.97441280472079,1.97233255435457,1.92170007475052,1.75283192459528,1.01802113474403,1.74629030419809,1.74171645650138,1.85281400832575,1.51429575840902,1.6099928362543,1.68476483220913,1.5051281172512,1.92428056626426,2.30758869016043,1.91198400781729,1.98989937197612,1.83563631264931,3.4350438200367,2.6011733073498,2.29977897242221,1.68293947182527,2.5432632093417,1.69734204267874,91801,"alkB homolog 8%2C tRNA methyltransferase","protein_coding",null,null,"GO:0000049,GO:0002098,GO:0005506,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006974,GO:0008270,GO:0008757,GO:0016300,GO:0016706,GO:0030488,GO:0106335","tRNA binding|tRNA wobble uridine modification|iron ion binding|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|DNA damage response|zinc ion binding|S-adenosylmethionine-dependent methyltransferase activity|tRNA (uracil) methyltransferase activity|2-oxoglutarate-dependent dioxygenase activity|tRNA methylation|tRNA (carboxymethyluridine(34)-5-O)-methyltransferase activity",null,null,"R-HSA-6782315,R-HSA-72306,R-HSA-8953854","tRNA modification in the nucleus and cytosol|tRNA processing|Metabolism of RNA"]
["ALLC",0,0,3.78061841875558E-3,0,0,0.00378148488453023,0,0,0.00405053756005649,0.00387844193971393,0,0.00405141801868454,0,0,0,0,0,0,0,0,0,0,0,0.0157367697984311,0,0,0,0,55821,"allantoicase","protein_coding","hsa00230","Purine metabolism","GO:0000256,GO:0004037","allantoin catabolic process|allantoicase activity"]
["ALMS1",1.69766802332594,1.78536555157178,1.25313533500161,1.25212492325146,1.60997897625563,1.44731133499392,1.31732966683217,1.28229046412098,1.85866680126407,1.76965398788828,1.59655862909404,1.81081051321742,1.81280473587882,1.50518254813953,1.7766593818172,1.71840710895711,1.4878330308873,1.31028017263587,1.10641038107751,1.57435277148721,1.57478808627775,1.35201559015719,1.68832567950189,1.62597419246609,1.67276900043589,1.39708652693342,1.34209267873405,1.24700095626665,7840,"ALMS1 centrosome and basal body associated protein","protein_coding",null,null,"GO:0000922,GO:0003674,GO:0005813,GO:0005814,GO:0005829,GO:0005929,GO:0008017,GO:0016197,GO:0046599,GO:0051492,GO:0120162","spindle pole|molecular_function|centrosome|centriole|cytosol|cilium|microtubule binding|endosomal transport|regulation of centriole replication|regulation of stress fiber assembly|positive regulation of cold-induced thermogenesis","WP5202,WP4803","Alstrom syndrome|Ciliopathies","R-HSA-1640170,R-HSA-1852241,R-HSA-2565942,R-HSA-380259,R-HSA-380270,R-HSA-380284,R-HSA-380287,R-HSA-380320,R-HSA-453274,R-HSA-5617833,R-HSA-5620912,R-HSA-68877,R-HSA-68886,R-HSA-69275,R-HSA-69278,R-HSA-8854518","Cell Cycle|Organelle biogenesis and maintenance|Regulation of PLK1 Activity at G2/M Transition|Loss of Nlp from mitotic centrosomes|Recruitment of mitotic centrosome proteins and complexes|Loss of proteins required for interphase microtubule organization from the centrosome|Centrosome maturation|Recruitment of NuMA to mitotic centrosomes|Mitotic G2-G2/M phases|Cilium Assembly|Anchoring of the basal body to the plasma membrane|Mitotic Prometaphase|M Phase|G2/M Transition|Cell Cycle, Mitotic|AURKA Activation by TPX2"]
["ALMS1-IT1",0.045791985110832,0.0435557753002364,0.171964618540089,0.190307775038378,0.223730001305647,0.272339714905924,0.142411695256418,0.0598713037826451,0.138181588812663,0.0441035509815035,0.0717745243941686,0.199639014055473,0.217738859076816,0.116418804242792,0.170345159984476,0.144725859270367,0.337534352273265,0.240095029273628,0.225716955981183,0.205494538739973,0.0288138958311721,0.174107878394918,0.165758157806798,0.268425094359084,0.0907984746795352,0.261063733798431,0.118165501222848,0.0860995286210522,100874291,"ALMS1 intronic transcript 1","non_coding"]
["ALOX12",0.1333318172926,0.0385975981549479,0.0598671089562685,0.0500372502309344,0.0509815719104222,0.0381059825202833,0.0919458906449073,0.0738992146366649,0.081634446877044,0.0223331529844688,0.0654213213316654,0.110813688628905,0.0330775763552394,0.0773746912929782,0.0754769486640897,0.0219858810728145,0.0445879881151631,0.0321827568650647,0.0160732316234987,0.0278727615525954,0.0164146258186613,0.0716338471718733,0.0629524530509261,0.0339812700099027,0.0804624189239006,0.0330493587016509,0.0560968481611694,0,239,"arachidonate 12-lipoxygenase%2C 12S type","protein_coding","hsa00590,hsa04726,hsa04750,hsa01523","Arachidonic acid metabolism|Serotonergic synapse|Inflammatory mediator regulation of TRP channels|Antifolate resistance","GO:0004052,GO:0005506,GO:0005515,GO:0005737,GO:0005829,GO:0006629,GO:0010656,GO:0016020,GO:0016165,GO:0019369,GO:0019372,GO:0019395,GO:0033559,GO:0034440,GO:0042383,GO:0042554,GO:0043651,GO:0047977,GO:0050473,GO:0051122,GO:0061436,GO:0070062,GO:0090331,GO:1901751,GO:2001303,GO:2001306","arachidonate 12(S)-lipoxygenase activity|iron ion binding|protein binding|cytoplasm|cytosol|lipid metabolic process|negative regulation of muscle cell apoptotic process|membrane|linoleate 13S-lipoxygenase activity|arachidonic acid metabolic process|lipoxygenase pathway|fatty acid oxidation|unsaturated fatty acid metabolic process|lipid oxidation|sarcolemma|superoxide anion generation|linoleic acid metabolic process|hepoxilin-epoxide hydrolase activity|arachidonate 15-lipoxygenase activity|hepoxilin biosynthetic process|establishment of skin barrier|extracellular exosome|negative regulation of platelet aggregation|leukotriene A4 metabolic process|lipoxin A4 biosynthetic process|lipoxin B4 biosynthetic process","WP167,WP4586,WP5122,WP4721,WP5321","Eicosanoid synthesis|Metabolism of alpha-linolenic acid|Prostaglandin and leukotriene metabolism in senescence |Eicosanoid metabolism via lipooxygenases (LOX)|Prostaglandin and leukotriene metabolism in senescence ","R-HSA-1430728,R-HSA-2142696,R-HSA-2142700,R-HSA-2142712,R-HSA-2142753,R-HSA-556833,R-HSA-8978868,R-HSA-9018677,R-HSA-9018678,R-HSA-9018683,R-HSA-9025094,R-HSA-9025106,R-HSA-9026290","Metabolism|Synthesis of Hepoxilins (HX) and Trioxilins (TrX)|Synthesis of Lipoxins (LX)|Synthesis of 12-eicosatetraenoic acid derivatives|Arachidonic acid metabolism|Metabolism of lipids|Fatty acid metabolism|Biosynthesis of DHA-derived SPMs|Biosynthesis of specialized proresolving mediators (SPMs)|Biosynthesis of DPA-derived SPMs|Biosynthesis of DPAn-3 SPMs|Biosynthesis of DPAn-6 SPMs|Biosynthesis of DPAn-3-derived maresins"]
["ALOX12-AS1",1.86333285036242,2.87512720950122,2.56573324098293,2.62099882162037,2.58954016052938,2.44967030487535,3.05198544577633,2.23321802473437,2.87386573189594,2.19343466811748,3.34894859197811,2.37457904204798,3.74091637350922,2.6054742986411,2.23350154210061,2.78749563601755,2.46826362780367,2.29876834750462,3.36772472111403,1.35381984684035,2.26678166067227,2.36155540127054,2.57532762481061,3.68130425107279,2.83260556415772,3.06886902229615,3.68636430773399,2.53030335135959,100506713,"ALOX12 antisense RNA 1","non_coding"]
["ALOX12B",0,0,0,0,0,0,0,0.0105102109821223,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,242,"arachidonate 12-lipoxygenase%2C 12R type","protein_coding","hsa00590,hsa04726","Arachidonic acid metabolism|Serotonergic synapse","GO:0004052,GO:0005506,GO:0005829,GO:0006497,GO:0006665,GO:0010628,GO:0016702,GO:0016829,GO:0016853,GO:0019369,GO:0019372,GO:0034440,GO:0043231,GO:0043410,GO:0043651,GO:0046513,GO:0047677,GO:0048471,GO:0051122,GO:0061436,GO:0070257,GO:0106237,GO:1990136","arachidonate 12(S)-lipoxygenase activity|iron ion binding|cytosol|protein lipidation|sphingolipid metabolic process|positive regulation of gene expression|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|lyase activity|isomerase activity|arachidonic acid metabolic process|lipoxygenase pathway|lipid oxidation|intracellular membrane-bounded organelle|positive regulation of MAPK cascade|linoleic acid metabolic process|ceramide biosynthetic process|arachidonate 8(R)-lipoxygenase activity|perinuclear region of cytoplasm|hepoxilin biosynthetic process|establishment of skin barrier|positive regulation of mucus secretion|arachidonate 12(R)-lipoxygenase activity|linoleate 9S-lipoxygenase activity","WP5324","Octadecanoid formation from linoleic acid","R-HSA-1430728,R-HSA-2142712,R-HSA-2142753,R-HSA-556833,R-HSA-8978868","Metabolism|Synthesis of 12-eicosatetraenoic acid derivatives|Arachidonic acid metabolism|Metabolism of lipids|Fatty acid metabolism"]
["ALOX15",0,0,0,0,0,0.00938570998036535,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,246,"arachidonate 15-lipoxygenase","protein_coding","hsa00590,hsa00591,hsa04216,hsa04217,hsa04726","Arachidonic acid metabolism|Linoleic acid metabolism|Ferroptosis|Necroptosis|Serotonergic synapse","GO:0001503,GO:0002820,GO:0004052,GO:0005506,GO:0005515,GO:0005546,GO:0005811,GO:0005829,GO:0005886,GO:0006629,GO:0006646,GO:0006954,GO:0009898,GO:0010811,GO:0016020,GO:0016165,GO:0019369,GO:0019372,GO:0019395,GO:0030282,GO:0030838,GO:0034440,GO:0034976,GO:0035358,GO:0035963,GO:0042060,GO:0042759,GO:0043277,GO:0043651,GO:0050473,GO:0050727,GO:0051122,GO:0070374,GO:0071277,GO:1901074,GO:2001303","ossification|negative regulation of adaptive immune response|arachidonate 12(S)-lipoxygenase activity|iron ion binding|protein binding|phosphatidylinositol-4,5-bisphosphate binding|lipid droplet|cytosol|plasma membrane|lipid metabolic process|phosphatidylethanolamine biosynthetic process|inflammatory response|cytoplasmic side of plasma membrane|positive regulation of cell-substrate adhesion|membrane|linoleate 13S-lipoxygenase activity|arachidonic acid metabolic process|lipoxygenase pathway|fatty acid oxidation|bone mineralization|positive regulation of actin filament polymerization|lipid oxidation|response to endoplasmic reticulum stress|regulation of peroxisome proliferator activated receptor signaling pathway|cellular response to interleukin-13|wound healing|long-chain fatty acid biosynthetic process|apoptotic cell clearance|linoleic acid metabolic process|arachidonate 15-lipoxygenase activity|regulation of inflammatory response|hepoxilin biosynthetic process|positive regulation of ERK1 and ERK2 cascade|cellular response to calcium ion|regulation of engulfment of apoptotic cell|lipoxin A4 biosynthetic process","WP5137,WP167,WP5136,WP4586,WP5122,WP4313,WP5324,WP4721,WP5321","Linoleic acid oxylipin metabolism|Eicosanoid synthesis|ALA oxylipin metabolism|Metabolism of alpha-linolenic acid|Prostaglandin and leukotriene metabolism in senescence |Ferroptosis|Octadecanoid formation from linoleic acid|Eicosanoid metabolism via lipooxygenases (LOX)|Prostaglandin and leukotriene metabolism in senescence ","R-HSA-1280215,R-HSA-1430728,R-HSA-168256,R-HSA-2142691,R-HSA-2142712,R-HSA-2142753,R-HSA-2142770,R-HSA-449147,R-HSA-556833,R-HSA-6785807,R-HSA-8978868,R-HSA-9018677,R-HSA-9018678,R-HSA-9018679,R-HSA-9018681,R-HSA-9018683,R-HSA-9018896,R-HSA-9023661,R-HSA-9025094,R-HSA-9025106,R-HSA-9026286","Cytokine Signaling in Immune system|Metabolism|Immune System|Synthesis of Leukotrienes (LT) and Eoxins (EX)|Synthesis of 12-eicosatetraenoic acid derivatives|Arachidonic acid metabolism|Synthesis of 15-eicosatetraenoic acid derivatives|Signaling by Interleukins|Metabolism of lipids|Interleukin-4 and Interleukin-13 signaling|Fatty acid metabolism|Biosynthesis of DHA-derived SPMs|Biosynthesis of specialized proresolving mediators (SPMs)|Biosynthesis of EPA-derived SPMs|Biosynthesis of protectins|Biosynthesis of DPA-derived SPMs|Biosynthesis of E-series 18(S)-resolvins|Biosynthesis of E-series 18(R)-resolvins|Biosynthesis of DPAn-3 SPMs|Biosynthesis of DPAn-6 SPMs|Biosynthesis of DPAn-3-derived protectins and resolvins"]
["ALOX5",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.00971665718269233,0,0,0,0,0,0,0,0,0,240,"arachidonate 5-lipoxygenase","protein_coding","hsa00590,hsa04664,hsa04913,hsa04726,hsa05145","Arachidonic acid metabolism|Fc epsilon RI signaling pathway|Ovarian steroidogenesis|Serotonergic synapse|Toxoplasmosis","GO:0001937,GO:0002232,GO:0002523,GO:0002540,GO:0004051,GO:0004052,GO:0005506,GO:0005515,GO:0005576,GO:0005615,GO:0005635,GO:0005641,GO:0005654,GO:0005829,GO:0006691,GO:0006959,GO:0016363,GO:0016525,GO:0016787,GO:0019369,GO:0019370,GO:0019372,GO:0030501,GO:0031965,GO:0034440,GO:0034774,GO:0036336,GO:0036403,GO:0042593,GO:0042759,GO:0043651,GO:0045598,GO:0048471,GO:0050727,GO:0050728,GO:0050796,GO:0051122,GO:0061044,GO:0061045,GO:0106014,GO:1900015,GO:1900407,GO:1901753,GO:1903426,GO:1903573,GO:1903671,GO:1904813,GO:1904999,GO:2001301","negative regulation of endothelial cell proliferation|leukocyte chemotaxis involved in inflammatory response|leukocyte migration involved in inflammatory response|leukotriene production involved in inflammatory response|arachidonate 5-lipoxygenase activity|arachidonate 12(S)-lipoxygenase activity|iron ion binding|protein binding|extracellular region|extracellular space|nuclear envelope|nuclear envelope lumen|nucleoplasm|cytosol|leukotriene metabolic process|humoral immune response|nuclear matrix|negative regulation of angiogenesis|hydrolase activity|arachidonic acid metabolic process|leukotriene biosynthetic process|lipoxygenase pathway|positive regulation of bone mineralization|nuclear membrane|lipid oxidation|secretory granule lumen|dendritic cell migration|arachidonate 8(S)-lipoxygenase activity|glucose homeostasis|long-chain fatty acid biosynthetic process|linoleic acid metabolic process|regulation of fat cell differentiation|perinuclear region of cytoplasm|regulation of inflammatory response|negative regulation of inflammatory response|regulation of insulin secretion|hepoxilin biosynthetic process|negative regulation of vascular wound healing|negative regulation of wound healing|regulation of inflammatory response to wounding|regulation of cytokine production involved in inflammatory response|regulation of cellular response to oxidative stress|leukotriene A4 biosynthetic process|regulation of reactive oxygen species biosynthetic process|negative regulation of response to endoplasmic reticulum stress|negative regulation of sprouting angiogenesis|ficolin-1-rich granule lumen|positive regulation of leukocyte adhesion to arterial endothelial cell|lipoxin biosynthetic process","WP5137,WP167,WP5136,WP4586,WP15,WP5122,WP5158,WP5149,WP5171,WP2877,WP4721,WP5315,WP5321","Linoleic acid oxylipin metabolism|Eicosanoid synthesis|ALA oxylipin metabolism|Metabolism of alpha-linolenic acid|Selenium micronutrient network|Prostaglandin and leukotriene metabolism in senescence |Urotensin-II-mediated signaling pathway|Lipid metabolism in senescent cells|Leukotriene metabolic pathway|Vitamin D receptor pathway|Eicosanoid metabolism via lipooxygenases (LOX)|Sebaleic acid formation and metabolism|Prostaglandin and leukotriene metabolism in senescence ","R-HSA-1280215,R-HSA-1430728,R-HSA-168249,R-HSA-168256,R-HSA-2142688,R-HSA-2142691,R-HSA-2142700,R-HSA-2142753,R-HSA-446652,R-HSA-449147,R-HSA-556833,R-HSA-6785807,R-HSA-6798695,R-HSA-8978868,R-HSA-9012546,R-HSA-9018676,R-HSA-9018677,R-HSA-9018678,R-HSA-9018679,R-HSA-9018682,R-HSA-9018683,R-HSA-9018896,R-HSA-9020265,R-HSA-9023661,R-HSA-9025094,R-HSA-9026286,R-HSA-9026290,R-HSA-9026403,R-HSA-9027604","Cytokine Signaling in Immune system|Metabolism|Innate Immune System|Immune System|Synthesis of 5-eicosatetraenoic acids|Synthesis of Leukotrienes (LT) and Eoxins (EX)|Synthesis of Lipoxins (LX)|Arachidonic acid metabolism|Interleukin-1 family signaling|Signaling by Interleukins|Metabolism of lipids|Interleukin-4 and Interleukin-13 signaling|Neutrophil degranulation|Fatty acid metabolism|Interleukin-18 signaling|Biosynthesis of D-series resolvins|Biosynthesis of DHA-derived SPMs|Biosynthesis of specialized proresolving mediators (SPMs)|Biosynthesis of EPA-derived SPMs|Biosynthesis of maresins|Biosynthesis of DPA-derived SPMs|Biosynthesis of E-series 18(S)-resolvins|Biosynthesis of aspirin-triggered D-series resolvins|Biosynthesis of E-series 18(R)-resolvins|Biosynthesis of DPAn-3 SPMs|Biosynthesis of DPAn-3-derived protectins and resolvins|Biosynthesis of DPAn-3-derived maresins|Biosynthesis of DPAn-3-derived 13-series resolvins|Biosynthesis of electrophilic ??-3 PUFA oxo-derivatives"]
["ALOX5AP",0.0200716420217744,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.0185506396250358,0,0,0,0,0,0,0,0,0,241,"arachidonate 5-lipoxygenase activating protein","protein_coding","hsa04664","Fc epsilon RI signaling pathway","GO:0002540,GO:0002675,GO:0004051,GO:0004364,GO:0004464,GO:0004602,GO:0005515,GO:0005635,GO:0005783,GO:0005789,GO:0008047,GO:0016020,GO:0019370,GO:0019372,GO:0019899,GO:0031965,GO:0042802,GO:0044877,GO:0050544,GO:0070207,GO:0071277,GO:0098869","leukotriene production involved in inflammatory response|positive regulation of acute inflammatory response|arachidonate 5-lipoxygenase activity|glutathione transferase activity|leukotriene-C4 synthase activity|glutathione peroxidase activity|protein binding|nuclear envelope|endoplasmic reticulum|endoplasmic reticulum membrane|enzyme activator activity|membrane|leukotriene biosynthetic process|lipoxygenase pathway|enzyme binding|nuclear membrane|identical protein binding|protein-containing complex binding|arachidonic acid binding|protein homotrimerization|cellular response to calcium ion|cellular oxidant detoxification","WP167,WP15,WP5122,WP2882,WP2880,WP5171,WP5321","Eicosanoid synthesis|Selenium micronutrient network|Prostaglandin and leukotriene metabolism in senescence |Nuclear receptors meta-pathway|Glucocorticoid receptor pathway|Leukotriene metabolic pathway|Prostaglandin and leukotriene metabolism in senescence ","R-HSA-1430728,R-HSA-2142688,R-HSA-2142691,R-HSA-2142700,R-HSA-2142753,R-HSA-556833,R-HSA-8978868,R-HSA-9018678","Metabolism|Synthesis of 5-eicosatetraenoic acids|Synthesis of Leukotrienes (LT) and Eoxins (EX)|Synthesis of Lipoxins (LX)|Arachidonic acid metabolism|Metabolism of lipids|Fatty acid metabolism|Biosynthesis of specialized proresolving mediators (SPMs)"]
["ALOXE3",0.050806006097658,0,0.0136281420006192,0.0278433810295991,0.0141844258591194,0.0136312653834385,0.00677164926825079,0.0142343460527936,0,0.04194231073416,0.00682573021432966,0.00730215191628281,0,0,0,0,0,0.00671557258223618,0.02683199678667,0,6.85047658021675E-3,6.89899733542957E-3,0,0.0283634725446145,0,0,0,0.00682336059705521,59344,"arachidonate lipoxygenase 3","protein_coding","hsa00590","Arachidonic acid metabolism","GO:0005506,GO:0005515,GO:0005829,GO:0006665,GO:0016702,GO:0019233,GO:0019369,GO:0019372,GO:0034440,GO:0035357,GO:0043651,GO:0045444,GO:0046513,GO:0050486,GO:0051120,GO:0051122,GO:0061436,GO:0106255,GO:0106256","iron ion binding|protein binding|cytosol|sphingolipid metabolic process|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|sensory perception of pain|arachidonic acid metabolic process|lipoxygenase pathway|lipid oxidation|peroxisome proliferator activated receptor signaling pathway|linoleic acid metabolic process|fat cell differentiation|ceramide biosynthetic process|intramolecular transferase activity, transferring hydroxy groups|hepoxilin A3 synthase activity|hepoxilin biosynthetic process|establishment of skin barrier|hydroperoxy icosatetraenoate isomerase activity|hydroperoxy icosatetraenoate dehydratase activity","WP5324","Octadecanoid formation from linoleic acid","R-HSA-1430728,R-HSA-2142712,R-HSA-2142753,R-HSA-556833,R-HSA-8978868","Metabolism|Synthesis of 12-eicosatetraenoic acid derivatives|Arachidonic acid metabolism|Metabolism of lipids|Fatty acid metabolism"]
["ALPK1",3.46002169994878,4.84397661071939,4.81868282397,4.34308009119955,4.56652864898689,4.16339594694134,4.30422533306722,4.00487900485107,3.31960571592128,3.42381009913778,3.40890039333779,3.08423745532203,3.63231488824089,3.94607240402637,4.29968768360151,3.94337891468297,3.42740737500354,3.55715135381133,3.05939182772523,3.57209134533651,3.47309646303903,3.25091130414762,3.93334906356516,3.21937759030658,3.4897457841039,3.12634445691807,3.15977264202505,3.64240821185244,80216,"alpha kinase 1","protein_coding",null,null,"GO:0000922,GO:0002753,GO:0004674,GO:0005515,GO:0005524,GO:0005813,GO:0005829,GO:0005929,GO:0016310,GO:0043123,GO:0045087,GO:0048029,GO:0060271,GO:0106310","spindle pole|cytosolic pattern recognition receptor signaling pathway|protein serine/threonine kinase activity|protein binding|ATP binding|centrosome|cytosol|cilium|phosphorylation|positive regulation of canonical NF-kappaB signal transduction|innate immune response|monosaccharide binding|cilium assembly|protein serine kinase activity",null,null,"R-HSA-1280215,R-HSA-166016,R-HSA-166058,R-HSA-166166,R-HSA-168138,R-HSA-168142,R-HSA-168164,R-HSA-168176,R-HSA-168179,R-HSA-168181,R-HSA-168188,R-HSA-168249,R-HSA-168256,R-HSA-168898,R-HSA-181438,R-HSA-445989,R-HSA-446652,R-HSA-449147,R-HSA-9020702,R-HSA-937061,R-HSA-9645460,R-HSA-975138,R-HSA-975155,R-HSA-975871","Cytokine Signaling in Immune system|Toll Like Receptor 4 (TLR4) Cascade|MyD88:MAL(TIRAP) cascade initiated on plasma membrane|MyD88-independent TLR4 cascade |Toll Like Receptor 9 (TLR9) Cascade|Toll Like Receptor 10 (TLR10) Cascade|Toll Like Receptor 3 (TLR3) Cascade|Toll Like Receptor 5 (TLR5) Cascade|Toll Like Receptor TLR1:TLR2 Cascade|Toll Like Receptor 7/8 (TLR7/8) Cascade|Toll Like Receptor TLR6:TLR2 Cascade|Innate Immune System|Immune System|Toll-like Receptor Cascades|Toll Like Receptor 2 (TLR2) Cascade|TAK1-dependent IKK and NF-kappa-B activation  |Interleukin-1 family signaling|Signaling by Interleukins|Interleukin-1 signaling|TRIF(TICAM1)-mediated TLR4 signaling |Alpha-protein kinase 1 signaling pathway|TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation|MyD88 dependent cascade initiated on endosome|MyD88 cascade initiated on plasma membrane"]
["ALPK2",6.79614139654173,6.89176096370646,4.92401427711199,6.09727364093234,7.61490244235947,6.6882554175735,4.77838057081706,5.70106517608453,2.95679656102081,2.67756846768715,2.17477291464582,2.70946656142076,2.15090976541532,2.69538413453612,1.86745968471889,2.07919120371438,4.78468772223096,4.65496726633725,2.13726216921849,4.33596279352275,5.16242961658704,4.4548041955351,2.61572763685327,4.32727736491574,5.49449402779629,4.2464893023168,2.30440602359527,4.24240174338328,115701,"alpha kinase 2","protein_coding",null,null,"GO:0003007,GO:0003308,GO:0004674,GO:0005524,GO:0010468,GO:0016310,GO:0016323,GO:0030010,GO:0042981,GO:0055013,GO:0106310,GO:1905223","heart morphogenesis|negative regulation of Wnt signaling pathway involved in heart development|protein serine/threonine kinase activity|ATP binding|regulation of gene expression|phosphorylation|basolateral plasma membrane|establishment of cell polarity|regulation of apoptotic process|cardiac muscle cell development|protein serine kinase activity|epicardium morphogenesis"]
["ALPK3",0.0236966142915792,0.015026274502875,0.0197753152530962,0.0101006365641659,0.0205825191016877,0.0197798474835283,0.0147391514254445,0.00774560869897572,0.0450227655068675,0.0456457536823609,0.0297137276999652,0.0556284466261536,0.0676058102396352,0.0552244503618987,0.044075437468146,0.0649075264139304,0.0253142880366659,0.0121809125661385,0.00243343514518686,0.0151914445656849,0.0124256055962712,0.00750816842267595,0.0155958500428069,0.0102893081686558,0.0104414993998866,0.01000713146856,0.0152871856192286,0.0272281279382783,57538,"alpha kinase 3","protein_coding",null,null,"GO:0004674,GO:0005524,GO:0005634,GO:0007507,GO:0016310,GO:0055013,GO:0106310","protein serine/threonine kinase activity|ATP binding|nucleus|heart development|phosphorylation|cardiac muscle cell development|protein serine kinase activity","WP5408","15q25 copy number variation"]
["ALPL",0.162214392566064,0.226901177522765,0.188126249061291,0.137270332491943,0.335666278773045,0.340496946211583,0.178052427485192,0.0561412685735316,0.566280922900557,0.707644727972485,0.861477222491311,0.662404694859515,0.508165243829165,0.900617930132049,0.559063770193301,0.606168252056227,0.082566694806176,0.176577958020709,0.105827294937018,0.15598880005187,0.0990688036135133,0.117910580300605,0.0376803097907393,0.0839006578120606,0.10406201587756,0.108799658734638,0.0554018429627125,0.0897060575485417,249,"alkaline phosphatase%2C biomineralization associated","protein_coding","hsa00730,hsa00790","Thiamine metabolism|Folate biosynthesis","GO:0001501,GO:0001649,GO:0001958,GO:0003006,GO:0004035,GO:0004427,GO:0005509,GO:0005515,GO:0005576,GO:0005758,GO:0005886,GO:0016020,GO:0016311,GO:0016462,GO:0016887,GO:0019725,GO:0030282,GO:0031012,GO:0031966,GO:0032496,GO:0032868,GO:0033280,GO:0033883,GO:0034516,GO:0036005,GO:0042822,GO:0043262,GO:0046677,GO:0050187,GO:0051384,GO:0052732,GO:0055062,GO:0055074,GO:0070062,GO:0071407,GO:0071529,GO:0098552,GO:0120162,GO:0140651,GO:0140928,GO:1904383","skeletal system development|osteoblast differentiation|endochondral ossification|developmental process involved in reproduction|alkaline phosphatase activity|inorganic diphosphate phosphatase activity|calcium ion binding|protein binding|extracellular region|mitochondrial intermembrane space|plasma membrane|membrane|dephosphorylation|pyrophosphatase activity|ATP hydrolysis activity|cellular homeostasis|bone mineralization|extracellular matrix|mitochondrial membrane|response to lipopolysaccharide|response to insulin|response to vitamin D|pyridoxal phosphatase activity|response to vitamin B6|response to macrophage colony-stimulating factor|pyridoxal phosphate metabolic process|ADP phosphatase activity|response to antibiotic|phosphoamidase activity|response to glucocorticoid|phosphoethanolamine phosphatase activity|phosphate ion homeostasis|calcium ion homeostasis|extracellular exosome|cellular response to organic cyclic compound|cementum mineralization|side of membrane|positive regulation of cold-induced thermogenesis|futile creatine cycle|inhibition of non-skeletal tissue mineralization|response to sodium phosphate","WP4808,WP3971,WP2380,WP4790,WP2813,WP474,WP4228,WP2324,WP3413,WP4747","Endochondral ossification with skeletal dysplasias|OSX and miRNAs in tooth development|Brain-derived neurotrophic factor (BDNF) signaling pathway|FGF23 signaling in hypophosphatemic rickets and related disorders|Mammary gland development pathway - Embryonic development (Stage 1 of 4)|Endochondral ossification|Vitamin B6-dependent and responsive disorders|AGE/RAGE pathway|NOTCH1 regulation of endothelial cell calcification|Netrin-UNC5B signaling pathway","R-HSA-163125,R-HSA-392499,R-HSA-597592","Post-translational modification: synthesis of GPI-anchored proteins|Metabolism of proteins|Post-translational protein modification"]
["ALPP",0,0.00931003379087601,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,250,"alkaline phosphatase%2C placental","protein_coding","hsa00730,hsa00790","Thiamine metabolism|Folate biosynthesis","GO:0000287,GO:0004035,GO:0005515,GO:0005886,GO:0008270,GO:0009986,GO:0016311,GO:0098552","magnesium ion binding|alkaline phosphatase activity|protein binding|plasma membrane|zinc ion binding|cell surface|dephosphorylation|side of membrane","WP5094","Orexin receptor pathway","R-HSA-199991,R-HSA-5653656,R-HSA-6811438,R-HSA-6811442","Membrane Trafficking|Vesicle-mediated transport|Intra-Golgi traffic|Intra-Golgi and retrograde Golgi-to-ER traffic"]
["ALS2",4.09193373514718,3.90813421140671,3.39873376029158,2.81633598793633,4.16781216802589,3.51930936111614,2.99804658320818,3.0306459430421,3.44285493019197,2.76105793376498,2.80015113972829,3.29103859478561,3.71055739223845,3.13698987115164,3.48089081010336,3.58993275768033,3.16814496989587,2.84181875737678,2.44040712483401,3.08773153293874,3.01022750022998,2.98350124469472,2.90616412892355,3.45684095533365,3.41013039676043,2.68505750644674,2.91386534762699,2.70640107723241,57679,"alsin Rho guanine nucleotide exchange factor ALS2","protein_coding","hsa05014,hsa05022","Amyotrophic lateral sclerosis|Pathways of neurodegeneration - multiple diseases","GO:0001662,GO:0001726,GO:0001881,GO:0005085,GO:0005096,GO:0005515,GO:0005634,GO:0005737,GO:0005769,GO:0005813,GO:0005829,GO:0006979,GO:0007032,GO:0007041,GO:0007528,GO:0007626,GO:0008104,GO:0014069,GO:0016197,GO:0030027,GO:0030425,GO:0030426,GO:0031267,GO:0031982,GO:0032991,GO:0035022,GO:0035249,GO:0042802,GO:0042803,GO:0043087,GO:0043197,GO:0043231,GO:0043539,GO:0043547,GO:0045860,GO:0048812,GO:0051036,GO:0051260","behavioral fear response|ruffle|receptor recycling|guanyl-nucleotide exchange factor activity|GTPase activator activity|protein binding|nucleus|cytoplasm|early endosome|centrosome|cytosol|response to oxidative stress|endosome organization|lysosomal transport|neuromuscular junction development|locomotory behavior|protein localization|postsynaptic density|endosomal transport|lamellipodium|dendrite|growth cone|small GTPase binding|vesicle|protein-containing complex|positive regulation of Rac protein signal transduction|synaptic transmission, glutamatergic|identical protein binding|protein homodimerization activity|regulation of GTPase activity|dendritic spine|intracellular membrane-bounded organelle|protein serine/threonine kinase activator activity|positive regulation of GTPase activity|positive regulation of protein kinase activity|neuron projection morphogenesis|regulation of endosome size|protein homooligomerization","WP2447,WP4754","Amyotrophic lateral sclerosis (ALS)|IL-18 signaling pathway","R-HSA-162582,R-HSA-194315,R-HSA-199991,R-HSA-5653656,R-HSA-8876198,R-HSA-9007101,R-HSA-9012999,R-HSA-9013149,R-HSA-9716542","Signal Transduction|Signaling by Rho GTPases|Membrane Trafficking|Vesicle-mediated transport|RAB GEFs exchange GTP for GDP on RABs|Rab regulation of trafficking|RHO GTPase cycle|RAC1 GTPase cycle|Signaling by Rho GTPases, Miro GTPases and RHOBTB3"]
["ALS2CL",0.707554100313269,0.693241983270167,0.454505394169851,0.857160710488476,1.14885451338169,0.889236283290719,0.307735175390087,0.678175149122738,0.62608504360788,0.855674459743897,0.375233303967145,0.63157345206528,0.708292290219751,0.669494283961065,0.321589384162523,0.489280227841572,0.296659275573798,0.241196011831623,0.098336329253693,0.2915995835609,0.346466199191992,0.308465648772629,0.215330663188888,0.358624119553887,0.284813687893533,0.247690822319951,0.0617762803906306,0.295081056678571,259173,"ALS2 C-terminal like","protein_coding",null,null,"GO:0005085,GO:0005096,GO:0005515,GO:0005737,GO:0005829,GO:0016197,GO:0031267,GO:0031410,GO:0043087","guanyl-nucleotide exchange factor activity|GTPase activator activity|protein binding|cytoplasm|cytosol|endosomal transport|small GTPase binding|cytoplasmic vesicle|regulation of GTPase activity",null,null,"R-HSA-199991,R-HSA-5653656,R-HSA-8876198,R-HSA-9007101","Membrane Trafficking|Vesicle-mediated transport|RAB GEFs exchange GTP for GDP on RABs|Rab regulation of trafficking"]
["ALX1",1.52870785833136,1.03399452794243,0.893016851246624,1.12402518634707,1.06224993352528,1.06867574526908,1.45796552940773,1.11595658572308,1.29847931975638,1.53777901221035,1.51753143763196,1.70889680006769,1.56685998897613,2.25092860370944,1.86399323665433,1.65881186827733,1.5350826721123,1.57162171206207,1.93091468747324,1.25769908933923,1.53906510511455,2.00203946872677,3.2531023599267,1.49350572349761,1.29667697793242,1.38798976525837,2.2189537765075,1.67668930814972,8092,"ALX homeobox 1","protein_coding",null,null,"GO:0000122,GO:0000785,GO:0000977,GO:0000981,GO:0001228,GO:0005515,GO:0005634,GO:0005654,GO:0005794,GO:0010718,GO:0016604,GO:0045892,GO:0045893,GO:0045944,GO:0048704,GO:1990837","negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|protein binding|nucleus|nucleoplasm|Golgi apparatus|positive regulation of epithelial to mesenchymal transition|nuclear body|negative regulation of DNA-templated transcription|positive regulation of DNA-templated transcription|positive regulation of transcription by RNA polymerase II|embryonic skeletal system morphogenesis|sequence-specific double-stranded DNA binding"]
["ALX3",0.261978562388552,0.0393450123683977,0.18122989040005,0.251252688712876,0.107787125607712,0.207167343771215,0.0385932051902048,0.243374553023366,0.291253333487152,0.172639270832627,0.0907699918732186,0.374549969238367,0.104900753658559,0.144600491766015,0.0769385044840374,0.065367229532345,0.0265133177411136,0.0255157407370078,0,0.0265183306843107,0.0260283069247314,0.131063304878698,0.176957720852289,0.269416718748589,0.0136700857872173,0,0.186798200270697,0.103701120235142,257,"ALX homeobox 3","protein_coding",null,null,"GO:0000785,GO:0000977,GO:0000981,GO:0005634,GO:0006357,GO:0007389,GO:0035115,GO:0035116,GO:0042981,GO:0048704,GO:1990837","chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|pattern specification process|embryonic forelimb morphogenesis|embryonic hindlimb morphogenesis|regulation of apoptotic process|embryonic skeletal system morphogenesis|sequence-specific double-stranded DNA binding"]
["ALX4",0.0894304329438832,0.183557387019901,0.141407143398777,0.212165396619729,0.179374659332112,0.167959467967124,0.193224347270904,0.138466111157872,0.0142034041000619,0.0135999425586406,0.02655920588373,0.0757679545090256,0.0537142413311903,0.0269245165391266,0.0569056542535885,0.102644926695369,0.00452536547790092,0.00871019262106694,0,4.52622110073577E-3,0.0177703300289331,0.0447404856011619,0.0232335592716166,0.013795434393753,0.0186659805929875,0.0134171047636351,0.0091094934153811,0.0265499856023709,60529,"ALX homeobox 4","protein_coding",null,null,"GO:0000785,GO:0000977,GO:0000981,GO:0001228,GO:0001501,GO:0001942,GO:0003677,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0006357,GO:0007517,GO:0009791,GO:0009952,GO:0035115,GO:0035116,GO:0042733,GO:0042981,GO:0045944,GO:0048565,GO:0048704,GO:0060021,GO:0071837,GO:1990837","chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|skeletal system development|hair follicle development|DNA binding|protein binding|nucleus|nucleoplasm|transcription regulator complex|regulation of transcription by RNA polymerase II|muscle organ development|post-embryonic development|anterior/posterior pattern specification|embryonic forelimb morphogenesis|embryonic hindlimb morphogenesis|embryonic digit morphogenesis|regulation of apoptotic process|positive regulation of transcription by RNA polymerase II|digestive tract development|embryonic skeletal system morphogenesis|roof of mouth development|HMG box domain binding|sequence-specific double-stranded DNA binding","WP5348","11p11.2 copy number variation syndrome "]
["ALYREF",75.6592403913523,61.4467831494354,59.7043807575641,72.3966486477111,53.7374581586338,55.679941603036,54.5869869783199,59.4927283052629,65.2522769802443,70.4792166324133,72.5628010303591,69.2714481241953,54.6586596158171,51.3286209855812,50.5724551621553,45.3624142175889,80.9396968851245,85.7382967247706,92.4547814091691,76.2054513095915,79.5518305970034,82.7312918501441,73.6249466971457,72.7406721064302,75.3513945209047,90.0783318596182,81.0847468429884,90.3947989065204,10189,"Aly/REF export factor","protein_coding","hsa03040,hsa03013,hsa03015,hsa05168,hsa05014","Spliceosome|Nucleocytoplasmic transport|mRNA surveillance pathway|Herpes simplex virus 1 infection|Amyotrophic lateral sclerosis","GO:0000018,GO:0000346,GO:0000398,GO:0000781,GO:0001649,GO:0003723,GO:0003729,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006405,GO:0006406,GO:0016020,GO:0016607,GO:0031297,GO:0032786,GO:0046784,GO:0062153,GO:0070062,GO:0071013","regulation of DNA recombination|transcription export complex|mRNA splicing, via spliceosome|chromosome, telomeric region|osteoblast differentiation|RNA binding|mRNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|RNA export from nucleus|mRNA export from nucleus|membrane|nuclear speck|replication fork processing|positive regulation of DNA-templated transcription, elongation|viral mRNA export from host cell nucleus|C5-methylcytidine-containing RNA binding|extracellular exosome|catalytic step 2 spliceosome",null,null,"R-HSA-159227,R-HSA-159230,R-HSA-159231,R-HSA-159234,R-HSA-159236,R-HSA-72163,R-HSA-72172,R-HSA-72187,R-HSA-72202,R-HSA-72203,R-HSA-73856,R-HSA-73857,R-HSA-74160,R-HSA-8953854","Transport of the SLBP independent Mature mRNA|Transport of the SLBP Dependant Mature mRNA|Transport of Mature mRNA Derived from an Intronless Transcript|Transport of Mature mRNAs Derived from Intronless Transcripts|Transport of Mature mRNA derived from an Intron-Containing Transcript|mRNA Splicing - Major Pathway|mRNA Splicing|mRNA 3'-end processing|Transport of Mature Transcript to Cytoplasm|Processing of Capped Intron-Containing Pre-mRNA|RNA Polymerase II Transcription Termination|RNA Polymerase II Transcription|Gene expression (Transcription)|Metabolism of RNA"]
["AMACR",0.203418372028368,0.293347651855747,0.326508121675497,0.169917147205826,0.346247774172537,0.246477700263343,0.330597587790483,0.25094791727884,0.151808389440462,0.132718621527104,0.129592503003025,0.0924251925606234,0.212169945706075,0.175166657503577,0.164767890262492,0.223979825437509,0.113559353859516,0.17000141771468,0.151615804627696,0.208231512183338,0.161029557081803,0.130983543860636,0.174906623009289,0.198734180133376,0.169145681734239,0.162109196163161,0.114296645352723,0.228250381335475,23600,"alpha-methylacyl-CoA racemase","protein_coding","hsa00120,hsa04146","Primary bile acid biosynthesis|Peroxisome","GO:0005737,GO:0005739,GO:0005777,GO:0005782,GO:0005829,GO:0005886,GO:0006699,GO:0008111,GO:0008206,GO:0033540,GO:0043231","cytoplasm|mitochondrion|peroxisome|peroxisomal matrix|cytosol|plasma membrane|bile acid biosynthetic process|alpha-methylacyl-CoA racemase activity|bile acid metabolic process|fatty acid beta-oxidation using acyl-CoA oxidase|intracellular membrane-bounded organelle","WP5064,WP5329,WP4545,WP5176","7-oxo-C and 7-beta-HC pathways|Cholesterol biosynthesis pathway in hepatocytes|Oxysterols derived from cholesterol|Disorders of bile acid synthesis and biliary transport","R-HSA-1430728,R-HSA-192105,R-HSA-193368,R-HSA-193775,R-HSA-194068,R-HSA-389887,R-HSA-390918,R-HSA-556833,R-HSA-8957322,R-HSA-8978868,R-HSA-9033241,R-HSA-9033241,R-HSA-9609507,R-HSA-9609507","Metabolism|Synthesis of bile acids and bile salts|Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol|Synthesis of bile acids and bile salts via 24-hydroxycholesterol|Bile acid and bile salt metabolism|Beta-oxidation of pristanoyl-CoA|Peroxisomal lipid metabolism|Metabolism of lipids|Metabolism of steroids|Fatty acid metabolism|Peroxisomal protein import|Peroxisomal protein import|Protein localization|Protein localization"]
["AMBN",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.0254948496230891,0,0.0124397189877432,0,0.0129285128398572,0,0,0,0,0,0,0,0,258,"ameloblastin","protein_coding",null,null,"GO:0005515,GO:0005576,GO:0005788,GO:0007155,GO:0007165,GO:0008083,GO:0030345,GO:0031214,GO:0042127,GO:0042475","protein binding|extracellular region|endoplasmic reticulum lumen|cell adhesion|signal transduction|growth factor activity|structural constituent of tooth enamel|biomineral tissue development|regulation of cell population proliferation|odontogenesis of dentin-containing tooth",null,null,"R-HSA-381426,R-HSA-392499,R-HSA-597592,R-HSA-8957275","Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)|Metabolism of proteins|Post-translational protein modification|Post-translational protein phosphorylation"]
["AMBP",0.192239252866234,0.0812672997149684,0.0200534545920363,0.245824842655937,0.208720117435696,0.080232202272727,0.239143315837877,0.670254976102385,0.0214851810039763,0.061717013497096,0.100438835245722,0.0429797024042382,0.0609392749809284,0.0610921973928597,0.0397292066207852,0.101262229584575,0.225898929485994,0.0197635788989106,0.0987064541062723,0.102700745815823,0.0604817829292987,0.0609101650644662,0,0,0.0423534353629316,0.0608872892086675,0.0826783974483163,0.100403966947159,259,"alpha-1-microglobulin/bikunin precursor","protein_coding",null,null,"GO:0004867,GO:0005515,GO:0005576,GO:0005615,GO:0005743,GO:0005783,GO:0005829,GO:0005886,GO:0007155,GO:0007565,GO:0009986,GO:0016491,GO:0019855,GO:0019862,GO:0020037,GO:0030246,GO:0031965,GO:0042167,GO:0042803,GO:0046329,GO:0046904,GO:0050777,GO:0062023,GO:0070062,GO:0072562","serine-type endopeptidase inhibitor activity|protein binding|extracellular region|extracellular space|mitochondrial inner membrane|endoplasmic reticulum|cytosol|plasma membrane|cell adhesion|female pregnancy|cell surface|oxidoreductase activity|calcium channel inhibitor activity|IgA binding|heme binding|carbohydrate binding|nuclear membrane|heme catabolic process|protein homodimerization activity|negative regulation of JNK cascade|calcium oxalate binding|negative regulation of immune response|collagen-containing extracellular matrix|extracellular exosome|blood microparticle","WP5055","Burn wound healing","R-HSA-2168880,R-HSA-2173782,R-HSA-5653656","Scavenging of heme from plasma|Binding and Uptake of Ligands by Scavenger Receptors|Vesicle-mediated transport"]
["AMBRA1",5.7555715445333,6.90737492005598,6.26825615228389,6.50927508825504,6.18811248825138,6.5964394602961,6.07646157376051,5.82051813197492,6.15990743307809,7.77094521927126,7.16827925191038,6.21890512494795,6.18590863205292,7.08735050606818,6.71936421437629,6.99416451303853,4.90785266676498,5.29891413242594,4.9448680766082,4.98751004784187,5.33581280123545,5.01562449472732,4.32011046107815,4.44323811849301,5.40588057631908,4.97873406712797,4.25045435167421,4.91060631200043,55626,"autophagy and beclin 1 regulator 1","protein_coding","hsa04140,hsa04137,hsa05010,hsa05014,hsa05016,hsa05017,hsa05022","Autophagy - animal|Mitophagy - animal|Alzheimer disease|Amyotrophic lateral sclerosis|Huntington disease|Spinocerebellar ataxia|Pathways of neurodegeneration - multiple diseases","GO:0000045,GO:0000209,GO:0000422,GO:0000423,GO:0005515,GO:0005634,GO:0005737,GO:0005739,GO:0005741,GO:0005776,GO:0005783,GO:0005829,GO:0005856,GO:0005925,GO:0005930,GO:0006357,GO:0006914,GO:0007049,GO:0008285,GO:0009267,GO:0010508,GO:0010667,GO:0019903,GO:0021915,GO:0030154,GO:0031625,GO:0035307,GO:0043161,GO:0043231,GO:0043524,GO:0043552,GO:0045335,GO:0045591,GO:0048471,GO:0051020,GO:0080008,GO:0098780,GO:1901526,GO:1904544,GO:1990756,GO:2000045","autophagosome assembly|protein polyubiquitination|autophagy of mitochondrion|mitophagy|protein binding|nucleus|cytoplasm|mitochondrion|mitochondrial outer membrane|autophagosome|endoplasmic reticulum|cytosol|cytoskeleton|focal adhesion|axoneme|regulation of transcription by RNA polymerase II|autophagy|cell cycle|negative regulation of cell population proliferation|cellular response to starvation|positive regulation of autophagy|negative regulation of cardiac muscle cell apoptotic process|protein phosphatase binding|neural tube development|cell differentiation|ubiquitin protein ligase binding|positive regulation of protein dephosphorylation|proteasome-mediated ubiquitin-dependent protein catabolic process|intracellular membrane-bounded organelle|negative regulation of neuron apoptotic process|positive regulation of phosphatidylinositol 3-kinase activity|phagocytic vesicle|positive regulation of regulatory T cell differentiation|perinuclear region of cytoplasm|GTPase binding|Cul4-RING E3 ubiquitin ligase complex|response to mitochondrial depolarisation|positive regulation of mitophagy|positive regulation of free ubiquitin chain polymerization|ubiquitin ligase-substrate adaptor activity|regulation of G1/S transition of mitotic cell cycle","WP5124,WP2059,WP5205,WP5156,WP2509,WP4923","Alzheimer's disease|Alzheimer's disease and miRNA effects|Clock-controlled autophagy in bone metabolism|SARS-CoV-2 replication organelle formation|Nanoparticle triggered autophagic cell death|Autophagy","R-HSA-1632852,R-HSA-9612973","Macroautophagy|Autophagy"]
["AMD1",31.5972961474289,23.6477832256814,19.9911119086213,20.8626255688994,25.220972817461,20.4548133605523,18.4573344589524,19.2703181943047,19.8769680943057,14.3165093209622,15.1871240772747,17.5906823367921,20.0001138787886,13.9350298934224,16.3078283418111,17.6363935079798,18.3185385728347,16.6907757450165,18.0545380717284,19.7535181663825,20.0221553180874,19.5258246432474,24.947585860521,21.7798874951802,19.5988286375887,17.8613263973946,20.9654756682696,16.732280321319,262,"adenosylmethionine decarboxylase 1","protein_coding","hsa00270,hsa00330","Cysteine and methionine metabolism|Arginine and proline metabolism","GO:0004014,GO:0005515,GO:0005829,GO:0006595,GO:0006597,GO:0008295,GO:0019810,GO:0042802","adenosylmethionine decarboxylase activity|protein binding|cytosol|polyamine metabolic process|spermine biosynthetic process|spermidine biosynthetic process|putrescine binding|identical protein binding","WP3580","Methionine de novo and salvage pathway","R-HSA-1430728,R-HSA-351202,R-HSA-71291","Metabolism|Metabolism of polyamines|Metabolism of amino acids and derivatives"]
["AMDHD1",0.339071889751485,0.207330186469589,0.147797383664397,0.336803593573001,0.26032818241171,0.341149054138077,0.293754510305197,0.30874334956019,0.657759261032786,0.396548909124498,0.375819922070382,0.402051367099485,0.426100405205072,0.253992777540485,0.360382812258264,0.390382726596134,0.500638377337537,0.436982850964323,0.481258260425065,0.384283491486592,0.377182439633659,0.425896862461842,0.334738601128423,0.236617109233374,0.540263161334431,0.632852162919079,0.480452115989531,0.387073981470684,144193,"amidohydrolase domain containing 1","protein_coding","hsa00340","Histidine metabolism","GO:0003674,GO:0005829,GO:0006548,GO:0016812,GO:0019556,GO:0019557,GO:0046872,GO:0050480","molecular_function|cytosol|histidine catabolic process|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides|histidine catabolic process to glutamate and formamide|histidine catabolic process to glutamate and formate|metal ion binding|imidazolonepropionase activity","WP4661","Amino acid metabolism pathway excerpt: histidine catabolism extension","R-HSA-1430728,R-HSA-70921,R-HSA-71291","Metabolism|Histidine catabolism|Metabolism of amino acids and derivatives"]
["AMDHD2",11.7501451025418,11.7789831365717,11.1473334371493,13.1867093977036,11.7149199149269,12.03847948564,10.3870030470786,11.9820736327094,10.3044266000114,14.2570696976974,12.7450259586036,12.3845566412525,9.17887598447475,13.5557543929299,10.2924233861499,11.0004906329295,5.61688197352759,6.06029997254531,6.12190926685611,6.39337849239387,5.35103774207549,6.20236286639251,5.11763822879032,5.38607278774175,6.07757576219088,6.04366439688386,5.4941006509497,6.25813390027094,51005,"amidohydrolase domain containing 2","protein_coding","hsa00520","Amino sugar and nucleotide sugar metabolism","GO:0005515,GO:0005634,GO:0005829,GO:0005975,GO:0006046,GO:0006048,GO:0008448,GO:0019262,GO:0046872,GO:0047419","protein binding|nucleus|cytosol|carbohydrate metabolic process|N-acetylglucosamine catabolic process|UDP-N-acetylglucosamine biosynthetic process|N-acetylglucosamine-6-phosphate deacetylase activity|N-acetylneuraminate catabolic process|metal ion binding|N-acetylgalactosamine-6-phosphate deacetylase activity",null,null,"R-HSA-392499,R-HSA-446193,R-HSA-446203,R-HSA-446210,R-HSA-446219,R-HSA-597592","Metabolism of proteins|Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein|Asparagine N-linked glycosylation|Synthesis of UDP-N-acetyl-glucosamine|Synthesis of substrates in N-glycan biosythesis|Post-translational protein modification"]
["AMER1",0.615629038321241,0.588615175519686,0.590015713125892,0.448968309236765,0.654830507132203,0.535953401621753,0.511553921775957,0.380446634355248,0.532158824843345,0.713368510713312,0.524685689400207,0.551629935663104,0.722674418585536,0.507447231125846,0.727592193191695,0.708356216496399,0.53331757819738,0.557752786397042,0.51267242296196,0.527251727097568,0.683959013236238,0.518126434833297,0.471648162206107,0.62338067887204,0.553128712053969,0.414345474860712,0.437491358354594,0.527517927923877,139285,"APC membrane recruitment protein 1","protein_coding",null,null,"GO:0005515,GO:0005546,GO:0005829,GO:0005886,GO:0008013,GO:0016055,GO:0016604,GO:0031398,GO:0043231,GO:0045732,GO:0060348,GO:0060612,GO:0060828,GO:0072161,GO:0090090,GO:0090263,GO:1904713","protein binding|phosphatidylinositol-4,5-bisphosphate binding|cytosol|plasma membrane|beta-catenin binding|Wnt signaling pathway|nuclear body|positive regulation of protein ubiquitination|intracellular membrane-bounded organelle|positive regulation of protein catabolic process|bone development|adipose tissue development|regulation of canonical Wnt signaling pathway|mesenchymal cell differentiation involved in kidney development|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|beta-catenin destruction complex binding",null,null,"R-HSA-162582,R-HSA-162582,R-HSA-1643685,R-HSA-195253,R-HSA-195721,R-HSA-195721,R-HSA-196299,R-HSA-201681,R-HSA-201681,R-HSA-2262752,R-HSA-392499,R-HSA-4641262,R-HSA-4641262,R-HSA-4791275,R-HSA-4839735,R-HSA-4839743,R-HSA-4839744,R-HSA-4839748,R-HSA-5339716,R-HSA-5358747,R-HSA-5358749,R-HSA-5358751,R-HSA-5358752,R-HSA-5467337,R-HSA-5467340,R-HSA-5467348,R-HSA-5663202,R-HSA-597592,R-HSA-8951664,R-HSA-8953897,R-HSA-9711123,R-HSA-9755511","Signal Transduction|Signal Transduction|Disease|Degradation of beta-catenin by the destruction complex|Signaling by WNT|Signaling by WNT|Beta-catenin phosphorylation cascade|TCF dependent signaling in response to WNT|TCF dependent signaling in response to WNT|Cellular responses to stress|Metabolism of proteins|Disassembly of the destruction complex and recruitment of AXIN to the membrane|Disassembly of the destruction complex and recruitment of AXIN to the membrane|Signaling by WNT in cancer|Signaling by AXIN mutants|Signaling by CTNNB1 phospho-site mutants|Signaling by APC mutants|Signaling by AMER1 mutants|Signaling by GSK3beta mutants|CTNNB1 S33 mutants aren't phosphorylated|CTNNB1 S37 mutants aren't phosphorylated|CTNNB1 S45 mutants aren't phosphorylated|CTNNB1 T41 mutants aren't phosphorylated|APC truncation mutants have impaired AXIN binding|AXIN missense mutants destabilize the destruction complex|Truncations of AMER1 destabilize the destruction complex|Diseases of signal transduction by growth factor receptors and second messengers|Post-translational protein modification|Neddylation|Cellular responses to stimuli|Cellular response to chemical stress|KEAP1-NFE2L2 pathway"]
["AMFR",29.8533200759853,27.1218011269151,25.5306916980318,25.5585272003251,28.6700337021319,28.7565212499118,24.7412486095908,27.0529000356886,27.4541712485267,28.6862818104824,24.1679618383926,26.7235877347912,27.1049162560444,27.4055891509107,26.2911621468242,26.7036209259304,25.411427209923,26.9853686292367,24.4335133691707,25.6508987288311,27.1140431886919,25.676405789239,21.2992586784862,24.0613895167611,25.7014272026794,25.3159775412054,22.179545261996,25.0831297125864,267,"autocrine motility factor receptor","protein_coding","hsa04141","Protein processing in endoplasmic reticulum","GO:0000151,GO:0000209,GO:0004842,GO:0005515,GO:0005783,GO:0005789,GO:0005794,GO:0005829,GO:0006511,GO:0007165,GO:0007611,GO:0016020,GO:0016055,GO:0030425,GO:0030426,GO:0030433,GO:0030674,GO:0030968,GO:0032092,GO:0032991,GO:0034450,GO:0036513,GO:0038023,GO:0038061,GO:0042802,GO:0043025,GO:0043130,GO:0046872,GO:0048471,GO:0051087,GO:0051865,GO:0061630,GO:0070936,GO:0090090,GO:1904288,GO:1990381,GO:2000638","ubiquitin ligase complex|protein polyubiquitination|ubiquitin-protein transferase activity|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|cytosol|ubiquitin-dependent protein catabolic process|signal transduction|learning or memory|membrane|Wnt signaling pathway|dendrite|growth cone|ubiquitin-dependent ERAD pathway|protein-macromolecule adaptor activity|endoplasmic reticulum unfolded protein response|positive regulation of protein binding|protein-containing complex|ubiquitin-ubiquitin ligase activity|Derlin-1 retrotranslocation complex|signaling receptor activity|non-canonical NF-kappaB signal transduction|identical protein binding|neuronal cell body|ubiquitin binding|metal ion binding|perinuclear region of cytoplasm|protein-folding chaperone binding|protein autoubiquitination|ubiquitin protein ligase activity|protein K48-linked ubiquitination|negative regulation of canonical Wnt signaling pathway|BAT3 complex binding|ubiquitin-specific protease binding|regulation of SREBP signaling pathway","WP1982","Sterol regulatory element-binding proteins (SREBP) signaling","R-HSA-392499,R-HSA-446203,R-HSA-532668,R-HSA-597592,R-HSA-901032,R-HSA-901042","Metabolism of proteins|Asparagine N-linked glycosylation|N-glycan trimming in the ER and Calnexin/Calreticulin cycle|Post-translational protein modification|ER Quality Control Compartment (ERQC)|Calnexin/calreticulin cycle"]
["AMH",0.104308184989884,0.170081811343764,0.1119180086021,0.1286197974427,0.174729544413829,0.153922530673023,0.180734532874342,0.160732441581214,0.0149885563443992,0.0861104157361362,0,0.11993451505616,0,0.0568257623805336,0.0138580040783391,0,0.343837719296034,0.399838286645843,0.344299461255156,0.257927047203122,0.267225389916846,0.0424923318470737,0.16181807998165,0.0582321376620776,0.295467304743061,0.353969776033436,0.158615466193688,0.350220581225304,268,"anti-Mullerian hormone","protein_coding","hsa04350,hsa04390,hsa04024,hsa04060","TGF-beta signaling pathway|Hippo signaling pathway|cAMP signaling pathway|Cytokine-cytokine receptor interaction","GO:0001541,GO:0001546,GO:0001655,GO:0001880,GO:0005102,GO:0005114,GO:0005179,GO:0005515,GO:0005576,GO:0005615,GO:0007267,GO:0007506,GO:0007530,GO:0007548,GO:0008083,GO:0009410,GO:0010628,GO:0014070,GO:0033327,GO:0060391,GO:1990262,GO:2000355","ovarian follicle development|preantral ovarian follicle growth|urogenital system development|Mullerian duct regression|signaling receptor binding|type II transforming growth factor beta receptor binding|hormone activity|protein binding|extracellular region|extracellular space|cell-cell signaling|gonadal mesoderm development|sex determination|sex differentiation|growth factor activity|response to xenobiotic stimulus|positive regulation of gene expression|response to organic cyclic compound|Leydig cell differentiation|positive regulation of SMAD protein signal transduction|anti-Mullerian hormone signaling pathway|negative regulation of ovarian follicle development","WP4871,WP5316,WP2857,WP4814,WP4842","Kisspeptin/kisspeptin receptor system in the ovary|Primary ovarian insufficiency|Mesodermal commitment pathway|Somatic sex determination|Mammalian disorder of sexual development","R-HSA-1266738,R-HSA-162582,R-HSA-201451,R-HSA-9006936,R-HSA-9690406","Developmental Biology|Signal Transduction|Signaling by BMP|Signaling by TGFB family members|Transcriptional regulation of testis differentiation"]
["AMHR2",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.024384140250009,0,0,0,269,"anti-Mullerian hormone receptor type 2","protein_coding","hsa04350,hsa04060","TGF-beta signaling pathway|Cytokine-cytokine receptor interaction","GO:0001568,GO:0001880,GO:0005024,GO:0005026,GO:0005515,GO:0005524,GO:0005886,GO:0006468,GO:0007179,GO:0007548,GO:0008584,GO:0008585,GO:0016310,GO:0030509,GO:0042562,GO:0042803,GO:0043235,GO:0046872,GO:0071363,GO:1990262,GO:1990272","blood vessel development|Mullerian duct regression|transforming growth factor beta receptor activity|transforming growth factor beta receptor activity, type II|protein binding|ATP binding|plasma membrane|protein phosphorylation|transforming growth factor beta receptor signaling pathway|sex differentiation|male gonad development|female gonad development|phosphorylation|BMP signaling pathway|hormone binding|protein homodimerization activity|receptor complex|metal ion binding|cellular response to growth factor stimulus|anti-Mullerian hormone signaling pathway|anti-Mullerian hormone receptor activity","WP5316,WP4842","Primary ovarian insufficiency|Mammalian disorder of sexual development","R-HSA-162582,R-HSA-201451,R-HSA-9006936","Signal Transduction|Signaling by BMP|Signaling by TGFB family members"]
["AMIGO1",0.691588029359007,0.602997045727653,0.629612213990123,0.562777236157448,1.1979926227347,0.988914523464746,0.444828258462156,0.693581998776502,1.23845677946536,1.22620729906708,1.35992425975152,1.05950605162914,1.25559779634174,1.19880821161965,1.46175681502714,1.11772245249913,0.639733634145034,0.732009158821031,0.648864957862137,0.584434113954129,0.761549306688912,0.682280665931702,0.589647413416307,0.542577518233917,1.15314945238293,0.617306777692644,0.674307011569975,0.679726074544198,57463,"adhesion molecule with Ig like domain 1","protein_coding",null,null,"GO:0005515,GO:0007156,GO:0007157,GO:0007409,GO:0007413,GO:0007420,GO:0010976,GO:0015459,GO:0030425,GO:0032809,GO:0042552,GO:0043204,GO:0050772,GO:0051965,GO:1901381,GO:1905232,GO:1990030","protein binding|homophilic cell adhesion via plasma membrane adhesion molecules|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules|axonogenesis|axonal fasciculation|brain development|positive regulation of neuron projection development|potassium channel regulator activity|dendrite|neuronal cell body membrane|myelination|perikaryon|positive regulation of axonogenesis|positive regulation of synapse assembly|positive regulation of potassium ion transmembrane transport|cellular response to L-glutamate|pericellular basket"]
["AMIGO2",13.002089689653,10.9182740175081,7.12490540357902,9.13709979305294,11.4492040886788,8.35260944518046,5.41826922211656,8.0353134831346,8.43388747742518,8.10175407570095,6.40164298134116,7.72419198109912,7.89618657052326,4.47341604824709,4.47120950303856,5.42894299724967,11.6834673512346,10.3818618418772,7.20254322220507,10.3189688418001,13.0101645127045,10.6524974316444,7.50552512787472,10.6365061292979,12.4388641983724,10.4417297774842,7.10034109791734,8.83516409127495,347902,"adhesion molecule with Ig like domain 2","protein_coding",null,null,"GO:0005515,GO:0005634,GO:0005886,GO:0007156,GO:0007157,GO:0007420,GO:0043069,GO:0051965","protein binding|nucleus|plasma membrane|homophilic cell adhesion via plasma membrane adhesion molecules|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules|brain development|negative regulation of programmed cell death|positive regulation of synapse assembly","WP2882,WP2880","Nuclear receptors meta-pathway|Glucocorticoid receptor pathway","R-HSA-162582,R-HSA-194315,R-HSA-9012999,R-HSA-9013149,R-HSA-9013423,R-HSA-9716542","Signal Transduction|Signaling by Rho GTPases|RHO GTPase cycle|RAC1 GTPase cycle|RAC3 GTPase cycle|Signaling by Rho GTPases, Miro GTPases and RHOBTB3"]
["AMIGO3",1.25531394477847,1.49027040895379,1.19625597298502,1.74704054698693,1.21741708833711,1.19653013841075,0.854180960112568,1.12914847186436,1.26267566204251,2.24533813553149,1.65987132247752,1.41488397771151,0.807829464558106,0.935834351472696,0.807548985556662,0.877010329558962,0.934673359058009,1.93874065778515,1.25614331175242,1.37958458440997,1.82624207068614,1.72254629269145,0.801333268877812,1.00510076473618,1.03868241115374,1.40801145659081,0.776340309373327,1.48183036764577,386724,"adhesion molecule with Ig like domain 3","protein_coding",null,null,"GO:0007157,GO:0007420,GO:0010977,GO:0016020,GO:0044877,GO:0051965","heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules|brain development|negative regulation of neuron projection development|membrane|protein-containing complex binding|positive regulation of synapse assembly"]
["AMMECR1",4.5050113132872,4.69770913943109,4.57614339693121,3.90887457354842,4.69979091281524,4.10040133337755,4.11700505915462,3.90160987919051,5.43214540404303,3.72096524285968,4.83140378832716,4.97822706450405,6.49657193141432,5.02547484311524,6.15996586592838,5.57562320477143,5.13897559083303,5.00968145498437,5.08082007509588,5.91227090768718,5.25408562377116,5.92748383839283,6.91266736369684,6.25467751119771,4.85077376315932,4.91651654212787,5.2348733409031,4.32201941993719,9949,"AMMECR nuclear protein 1","protein_coding",null,null,"GO:0005515,GO:0005634,GO:0005654,GO:0005739,GO:0008150","protein binding|nucleus|nucleoplasm|mitochondrion|biological_process"]
["AMMECR1L",6.29154248074489,5.32409724286101,4.78254207459917,4.55466311769309,5.8582874894908,5.34395275764156,4.36270004523272,4.39027228187046,5.75275507960678,5.8640920820159,4.63421549276445,5.32929541383557,5.74387306924591,4.93401597224218,5.02062070055136,5.28798346492694,4.91720039088128,5.44201647199911,4.3066869975687,4.75809570687108,5.11841697715461,4.65309269404687,4.7284788694259,4.968884471445,4.9981135372384,4.56263789965985,4.97269289926198,4.44180739402002,83607,"AMMECR1 like","protein_coding",null,null,"GO:0005634","nucleus"]
["AMN",0.587208963200939,0.121191155031169,0.197633265190237,0.488786949097907,0.346442795829147,0.218486829493609,0.284267323474227,0.581247498221136,0.345476058872817,0.432171294266348,0.250069169085281,0.546193760228789,0.284483471119352,0.279915927854419,0.170012591340857,0.294139099432845,0.138478415616605,0.0563826556257043,0.174077128351497,0.250373696560613,0.067972607942052,0.247487705893529,0.306258991414661,0.324728535852954,0.466836519870702,0.268449630637639,0.25195162691376,0.177070834926786,81693,"amnion associated transmembrane protein","protein_coding",null,null,"GO:0005102,GO:0005515,GO:0005615,GO:0005886,GO:0005905,GO:0006898,GO:0008104,GO:0009235,GO:0010008,GO:0015889,GO:0016020,GO:0016324,GO:0030139,GO:0031526,GO:0031528,GO:0038024,GO:0043001,GO:0043235,GO:0070062,GO:0097017","signaling receptor binding|protein binding|extracellular space|plasma membrane|clathrin-coated pit|receptor-mediated endocytosis|protein localization|cobalamin metabolic process|endosome membrane|cobalamin transport|membrane|apical plasma membrane|endocytic vesicle|brush border membrane|microvillus membrane|cargo receptor activity|Golgi to plasma membrane protein transport|receptor complex|extracellular exosome|renal protein absorption","WP4271","Vitamin B12 disorders","R-HSA-1430728,R-HSA-1643685,R-HSA-174824,R-HSA-196741,R-HSA-196849,R-HSA-196854,R-HSA-3296469,R-HSA-3296482,R-HSA-3359462,R-HSA-3359463,R-HSA-382551,R-HSA-5668914,R-HSA-8964011,R-HSA-8964043,R-HSA-9758881","Metabolism|Disease|Plasma lipoprotein assembly, remodeling, and clearance|Cobalamin (Cbl, vitamin B12) transport and metabolism|Metabolism of water-soluble vitamins and cofactors|Metabolism of vitamins and cofactors|Defects in cobalamin (B12) metabolism|Defects in vitamin and cofactor metabolism|Defective AMN causes MGA1|Defective CUBN causes MGA1|Transport of small molecules|Diseases of metabolism|HDL clearance|Plasma lipoprotein clearance|Uptake of dietary cobalamins into enterocytes"]
["AMN1",0.708679074603876,0.573588688639767,0.524828115820384,0.536132849333738,0.572058080194511,0.549749110984166,0.472279411979523,0.630183600673664,0.442754709781486,0.279802606586116,0.347724364687411,0.358709270016822,0.56929728083642,0.344114138635026,0.544447127243005,0.550903568031252,0.647496002296963,0.54575102881074,0.565476445669956,0.681480827444499,0.577487121592191,0.5062651875503,0.938623654241882,0.731063410157524,0.62404923793328,0.627365765686956,0.881711645942744,0.422090145045922,196394,"antagonist of mitotic exit network 1 homolog","protein_coding",null,null,"GO:0019005,GO:0031146,GO:0031528","SCF ubiquitin ligase complex|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|microvillus membrane"]
["AMOT",6.46533991047751,7.46488246091293,8.31113196298302,5.98870455450973,7.93387916276652,7.5207200946929,8.67485868172912,6.48435371066634,12.5080740725308,9.77737726050894,10.1358965258439,11.2206384641752,14.7455283167759,11.6574829444354,13.7847516774495,14.1142065181735,9.77310991518141,10.201566168974,8.81302616802547,11.6616920108627,10.0083139920426,10.5088482045335,11.9456901883009,10.6342888239597,8.95923771085736,8.69469884883856,10.6173963125364,8.75369447981676,154796,"angiomotin","protein_coding","hsa04390,hsa04530","Hippo signaling pathway|Tight junction","GO:0001525,GO:0001570,GO:0001701,GO:0001702,GO:0001726,GO:0003365,GO:0005515,GO:0005654,GO:0005829,GO:0005884,GO:0005886,GO:0005923,GO:0006935,GO:0008104,GO:0009897,GO:0016525,GO:0030027,GO:0030036,GO:0030054,GO:0030139,GO:0030334,GO:0031410,GO:0035329,GO:0038023,GO:0040019,GO:0042074,GO:0043532,GO:0043534,GO:0051056,GO:0090162","angiogenesis|vasculogenesis|in utero embryonic development|gastrulation with mouth forming second|ruffle|establishment of cell polarity involved in ameboidal cell migration|protein binding|nucleoplasm|cytosol|actin filament|plasma membrane|bicellular tight junction|chemotaxis|protein localization|external side of plasma membrane|negative regulation of angiogenesis|lamellipodium|actin cytoskeleton organization|cell junction|endocytic vesicle|regulation of cell migration|cytoplasmic vesicle|hippo signaling|signaling receptor activity|positive regulation of embryonic development|cell migration involved in gastrulation|angiostatin binding|blood vessel endothelial cell migration|regulation of small GTPase mediated signal transduction|establishment of epithelial cell polarity","WP4541,WP5087,WP3888","Hippo-Merlin signaling dysregulation|Pleural mesothelioma|VEGFA-VEGFR2 signaling","R-HSA-1500931,R-HSA-162582,R-HSA-2028269,R-HSA-418990,R-HSA-421270,R-HSA-446728,R-HSA-9759475,R-HSA-9759476,R-HSA-9762292,R-HSA-9764260","Cell-Cell communication|Signal Transduction|Signaling by Hippo|Adherens junctions interactions|Cell-cell junction organization|Cell junction organization|Regulation of CDH11 Expression and Function|Regulation of Homotypic Cell-Cell Adhesion|Regulation of CDH11 function|Regulation of Expression and Function of Type II Classical Cadherins"]
["AMOTL1",8.89531017988167,8.65691176782554,6.98197463445066,6.18788530313754,8.92485398729013,7.95107257630612,7.18818401624085,7.04587411543746,6.4548880798163,5.94351648310238,5.50151551345383,6.69860401430368,6.67790720500495,5.84762650410789,7.10287851126775,7.12230249173447,5.31817329951723,5.09083736610684,4.45193251559234,6.28162336775474,5.47347026020158,5.20953541750745,5.01958360969407,5.44069718457468,5.51586536557396,4.2057302146045,4.64833085862445,4.56371664062721,154810,"angiomotin like 1","protein_coding","hsa04530","Tight junction","GO:0001525,GO:0003365,GO:0005515,GO:0005829,GO:0005886,GO:0005923,GO:0016055,GO:0030036,GO:0030334,GO:0031410,GO:0035329,GO:0042802","angiogenesis|establishment of cell polarity involved in ameboidal cell migration|protein binding|cytosol|plasma membrane|bicellular tight junction|Wnt signaling pathway|actin cytoskeleton organization|regulation of cell migration|cytoplasmic vesicle|hippo signaling|identical protein binding",null,null,"R-HSA-162582,R-HSA-2028269","Signal Transduction|Signaling by Hippo"]
["AMOTL2",42.5340318963185,47.4976302788172,42.6030835076064,41.4397978002158,46.4268058237979,43.5438763615764,39.61122205309,36.5524109440577,43.4309135982933,54.0693568409731,46.2689240107531,44.3438382659692,40.3507576687827,37.7944747865369,37.3164587116774,38.2911236073181,35.6586381700175,41.1995683614687,38.1738477264931,39.0147812429097,38.4555203116777,36.5272774497061,32.2025882677711,35.0125521500068,36.27665123552,34.4272108408589,30.6560687295093,34.0674430075774,51421,"angiomotin like 2","protein_coding","hsa04530","Tight junction","GO:0001525,GO:0003365,GO:0005515,GO:0005829,GO:0005886,GO:0005923,GO:0016055,GO:0030036,GO:0030334,GO:0031410,GO:0035329,GO:0055037","angiogenesis|establishment of cell polarity involved in ameboidal cell migration|protein binding|cytosol|plasma membrane|bicellular tight junction|Wnt signaling pathway|actin cytoskeleton organization|regulation of cell migration|cytoplasmic vesicle|hippo signaling|recycling endosome",null,null,"R-HSA-162582,R-HSA-2028269","Signal Transduction|Signaling by Hippo"]
["AMPD1",0,0,0,0,0,0,0.0107708374228194,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,270,"adenosine monophosphate deaminase 1","protein_coding","hsa00230","Purine metabolism","GO:0003876,GO:0005515,GO:0005829,GO:0006188,GO:0032263,GO:0032264,GO:0042802,GO:0046033,GO:0046872","AMP deaminase activity|protein binding|cytosol|IMP biosynthetic process|GMP salvage|IMP salvage|identical protein binding|AMP metabolic process|metal ion binding","WP4792,WP4224","Purine metabolism|Purine metabolism and related disorders","R-HSA-1430728,R-HSA-15869,R-HSA-74217,R-HSA-8956321","Metabolism|Metabolism of nucleotides|Purine salvage|Nucleotide salvage"]
["AMPD2",13.5354341623089,14.0619216759046,16.7261258902018,14.7650482358743,13.8237720841386,15.4738665280473,14.8569856936929,14.2471845449684,13.3905679849877,19.398100677962,17.9587865132393,15.2326788516034,12.4904586234618,15.3759475483605,15.1824618608423,15.6419517190714,12.7011760450568,14.9579096445508,15.7475511859479,14.7800060190368,13.2383646932119,14.2766403243681,12.4821034493321,11.6368987622522,13.8929676207045,13.7507823255829,13.1781199282584,15.431529811078,271,"adenosine monophosphate deaminase 2","protein_coding","hsa00230","Purine metabolism","GO:0003876,GO:0005515,GO:0005829,GO:0006188,GO:0032264,GO:0046033,GO:0046872,GO:0052652,GO:0097009","AMP deaminase activity|protein binding|cytosol|IMP biosynthetic process|IMP salvage|AMP metabolic process|metal ion binding|cyclic purine nucleotide metabolic process|energy homeostasis",null,null,"R-HSA-1430728,R-HSA-15869,R-HSA-74217,R-HSA-8956321","Metabolism|Metabolism of nucleotides|Purine salvage|Nucleotide salvage"]
["AMPD3",1.5937208781522,2.20625187506178,1.79167856248848,1.64529689298854,2.5046021096393,2.0732946752805,1.33539320613894,1.81662792813289,1.00574595935277,0.919019127236994,1.02625001571161,0.924261869947365,1.00397388598467,0.846809250876362,0.929884859237423,0.818105770479189,1.51762660075181,1.49339868751557,1.04138561507172,1.80587784790964,1.81562265810065,1.49076797515904,1.31279802728373,1.26941893616356,1.40393145211989,1.45644933235198,1.09526693091178,1.30264647397616,272,"adenosine monophosphate deaminase 3","protein_coding","hsa00230","Purine metabolism","GO:0003876,GO:0005515,GO:0005576,GO:0005829,GO:0006188,GO:0006196,GO:0032264,GO:0034774,GO:0046033,GO:0046872,GO:1904813","AMP deaminase activity|protein binding|extracellular region|cytosol|IMP biosynthetic process|AMP catabolic process|IMP salvage|secretory granule lumen|AMP metabolic process|metal ion binding|ficolin-1-rich granule lumen",null,null,"R-HSA-1430728,R-HSA-15869,R-HSA-168249,R-HSA-168256,R-HSA-6798695,R-HSA-74217,R-HSA-8956321","Metabolism|Metabolism of nucleotides|Innate Immune System|Immune System|Neutrophil degranulation|Purine salvage|Nucleotide salvage"]
["AMPH",11.4263478498067,15.8494872359382,16.0246944862003,13.9570195166623,13.2800311849058,16.1889260410208,17.0415904719749,15.1327324354294,18.8493020598118,18.2225354302348,21.4181320258584,19.9297534324459,19.6374880974153,20.897686988258,22.070647067224,21.2139049115499,11.5916244383661,12.1950952278012,9.54461001462821,12.1857208091178,11.6608395211782,11.813083872423,10.5038643573736,10.972322998984,11.1104006226782,11.144875034082,9.93197848201829,11.2105341481455,273,"amphiphysin","protein_coding","hsa04144,hsa04666","Endocytosis|Fc gamma R-mediated phagocytosis","GO:0005515,GO:0005543,GO:0005829,GO:0005886,GO:0006897,GO:0007268,GO:0008021,GO:0015629,GO:0030672,GO:0031256,GO:0048488","protein binding|phospholipid binding|cytosol|plasma membrane|endocytosis|chemical synaptic transmission|synaptic vesicle|actin cytoskeleton|synaptic vesicle membrane|leading edge membrane|synaptic vesicle endocytosis","WP5323,WP5180,WP727","Fatty Acids and Lipoproteins Transport in Hepatocytes|DYRK1A involvement regarding cell proliferation in brain development|Monoamine transport","R-HSA-199991,R-HSA-5653656,R-HSA-8856828","Membrane Trafficking|Vesicle-mediated transport|Clathrin-mediated endocytosis"]
["AMT",3.13161839488052,4.57074640429936,4.86633175910743,6.08448285649069,4.47141828748646,5.22236506991622,3.6522146023346,4.61951929714231,3.84243688274719,6.03229980962569,5.30626866434477,5.26922112179511,2.83693634964628,6.98788278060682,4.01708632992937,5.18338889964671,2.68641512019593,4.29640609926202,2.33291246172815,3.80322924159576,2.66275314669771,3.31031649212651,1.9455738323974,2.37375421451248,3.15828952453997,3.53993882137362,1.64582590574006,3.57858441392317,275,"aminomethyltransferase","protein_coding","hsa00630,hsa00260,hsa00785,hsa00670","Glyoxylate and dicarboxylate metabolism|Glycine, serine and threonine metabolism|Lipoic acid metabolism|One carbon pool by folate","GO:0004047,GO:0005654,GO:0005739,GO:0005759,GO:0006546,GO:0008483,GO:0019464","aminomethyltransferase activity|nucleoplasm|mitochondrion|mitochondrial matrix|glycine catabolic process|transaminase activity|glycine decarboxylation via glycine cleavage system","WP2525,WP5355,WP241","Trans-sulfuration, one-carbon metabolism and related pathways|Metabolic Epileptic Disorders|One-carbon metabolism","R-HSA-1430728,R-HSA-389661,R-HSA-6783984,R-HSA-71291","Metabolism|Glyoxylate metabolism and glycine degradation|Glycine degradation|Metabolism of amino acids and derivatives"]
["AMTN",0,0,0,0,0,0,0.0997023008217382,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,401138,"amelotin","protein_coding",null,null,"GO:0003674,GO:0005515,GO:0005576,GO:0005604,GO:0005788,GO:0005911,GO:0007155,GO:0031012,GO:0031214,GO:0042475,GO:0070169,GO:0070175","molecular_function|protein binding|extracellular region|basement membrane|endoplasmic reticulum lumen|cell-cell junction|cell adhesion|extracellular matrix|biomineral tissue development|odontogenesis of dentin-containing tooth|positive regulation of biomineral tissue development|positive regulation of enamel mineralization",null,null,"R-HSA-381426,R-HSA-392499,R-HSA-597592,R-HSA-8957275","Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)|Metabolism of proteins|Post-translational protein modification|Post-translational protein phosphorylation"]
["AMY1B",0,0,0,0,0,0,0,0.0135208085012981,0,0,0,0.0832333264974149,0,0,0.0128230840806729,0,0,0,0,0,0,0,0,0,0,0,0,0,277,"amylase alpha 1B","protein_coding","hsa00500,hsa04970,hsa04972,hsa04973","Starch and sucrose metabolism|Salivary secretion|Pancreatic secretion|Carbohydrate digestion and absorption","GO:0004556,GO:0005509,GO:0005615,GO:0005975,GO:0009311,GO:0031404,GO:0070062","alpha-amylase activity|calcium ion binding|extracellular space|carbohydrate metabolic process|oligosaccharide metabolic process|chloride ion binding|extracellular exosome",null,null,"R-HSA-189085,R-HSA-8935690,R-HSA-8963743","Digestion of dietary carbohydrate|Digestion|Digestion and absorption"]
["AMY1C",0,0,0,0,0,0,0,0.0129447505485004,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,278,"amylase alpha 1C","protein_coding","hsa00500,hsa04970,hsa04972,hsa04973","Starch and sucrose metabolism|Salivary secretion|Pancreatic secretion|Carbohydrate digestion and absorption","GO:0004556,GO:0005509,GO:0005615,GO:0005975,GO:0009311,GO:0031404,GO:0070062","alpha-amylase activity|calcium ion binding|extracellular space|carbohydrate metabolic process|oligosaccharide metabolic process|chloride ion binding|extracellular exosome",null,null,"R-HSA-189085,R-HSA-8935690,R-HSA-8963743","Digestion of dietary carbohydrate|Digestion|Digestion and absorption"]
["AMY2A",0,0,0,0,0,0,0,0,0,0,0.0160042689495078,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,279,"amylase alpha 2A","protein_coding","hsa00500,hsa04970,hsa04972,hsa04973","Starch and sucrose metabolism|Salivary secretion|Pancreatic secretion|Carbohydrate digestion and absorption","GO:0004556,GO:0005509,GO:0005576,GO:0005615,GO:0005975,GO:0016052,GO:0031404,GO:0044245,GO:0070062","alpha-amylase activity|calcium ion binding|extracellular region|extracellular space|carbohydrate metabolic process|carbohydrate catabolic process|chloride ion binding|polysaccharide digestion|extracellular exosome",null,null,"R-HSA-189085,R-HSA-8935690,R-HSA-8963743","Digestion of dietary carbohydrate|Digestion|Digestion and absorption"]
["AMY2B",0.433583689542945,0.834878832477842,0.655273573903449,1.30834944209171,0.940362327444104,0.734869057066048,0.710393561210046,0.580721112091847,0.94671344056674,0.539820081700898,0.805575411258395,1.06395418662512,0.412334244287066,0.856984440216041,0.796625923732819,0.431157014565444,0.335525047875234,0.313115876913929,0.263893583147675,0.366096530710433,0.199628638830325,0.392033020026533,0.375842242616535,0.247960620707803,0.314535320290426,0.411982492249885,0.429804411372161,0.40761883544762,280,"amylase alpha 2B","protein_coding","hsa00500,hsa04970,hsa04972,hsa04973","Starch and sucrose metabolism|Salivary secretion|Pancreatic secretion|Carbohydrate digestion and absorption","GO:0004556,GO:0005615,GO:0005975,GO:0046872,GO:0070062","alpha-amylase activity|extracellular space|carbohydrate metabolic process|metal ion binding|extracellular exosome",null,null,"R-HSA-189085,R-HSA-8935690,R-HSA-8963743","Digestion of dietary carbohydrate|Digestion|Digestion and absorption"]
["AMZ1",0.209504263486345,0.08856591730595,0.060880269436889,0.0908954490069713,0.126730653095856,0.0905606383782773,0.0977327929363347,0.15326418568243,0.132126176642884,0.120106820616418,0.0406562924017104,0.153901905006836,0.0901308867192636,0.0998683330437682,0.0417509556623685,0.107203546681839,0.108705911069073,0.0123077407206638,0.0630060368661083,0.0543632321917757,0.0470811806419782,0.0821853909077747,0.123111208316569,0.152697725155527,0.145065479819446,0.0900539983126961,0.168944523283314,0.057836945875039,155185,"archaelysin family metallopeptidase 1","protein_coding",null,null,"GO:0005575,GO:0006508,GO:0008237,GO:0046872","cellular_component|proteolysis|metallopeptidase activity|metal ion binding"]
["AMZ2",34.0751211113223,29.2882286984983,36.2105158428829,32.6086928321422,30.7842016958774,31.23997496538,38.4931346469872,34.3829310390716,27.5524877196897,21.173030635655,29.0279714846429,30.3912914754207,28.8382488219694,27.5430852851815,28.5473846165629,28.1275420567734,40.6679754726084,36.1589827773054,43.993898460219,35.0356327979425,39.3323420631548,35.8538471298535,48.1989940239321,42.3630710506779,38.7444285187734,38.1826262603366,52.9617706615512,40.5451402223265,51321,"archaelysin family metallopeptidase 2","protein_coding",null,null,"GO:0005575,GO:0006508,GO:0008237,GO:0046872","cellular_component|proteolysis|metallopeptidase activity|metal ion binding"]
["ANAPC1",4.55955680030875,3.84830809872836,3.03169333035785,2.70675757859877,4.08318309944516,3.13265478519478,2.85396635319778,2.77320597448207,3.78804832964979,3.26300491000733,2.53751873300278,3.0804543349016,3.01056936921268,2.897069044164,2.89579173520554,2.83741081862662,3.16849900021345,3.15875774144235,2.86181299375035,3.41330178139534,3.16501258558943,2.93506877540418,3.05973514400473,3.0730840210754,3.47044711348827,2.8105753472459,2.8763071862533,2.35486804105319,64682,"anaphase promoting complex subunit 1","protein_coding","hsa04120,hsa04110,hsa04114,hsa04914,hsa05166","Ubiquitin mediated proteolysis|Cell cycle|Oocyte meiosis|Progesterone-mediated oocyte maturation|Human T-cell leukemia virus 1 infection","GO:0005654,GO:0005680,GO:0005829,GO:0007091,GO:0007346,GO:0031145,GO:0051301,GO:0051445,GO:0060090,GO:0070979","nucleoplasm|anaphase-promoting complex|cytosol|metaphase/anaphase transition of mitotic cell cycle|regulation of mitotic cell cycle|anaphase-promoting complex-dependent catabolic process|cell division|regulation of meiotic cell cycle|molecular adaptor activity|protein K11-linked ubiquitination","WP179,WP5222","Cell cycle|2q13 copy number variation syndrome","R-HSA-1280218,R-HSA-141405,R-HSA-141430,R-HSA-1640170,R-HSA-1643685,R-HSA-168256,R-HSA-174048,R-HSA-174084,R-HSA-174143,R-HSA-174154,R-HSA-174178,R-HSA-174184,R-HSA-176407,R-HSA-176408,R-HSA-176409,R-HSA-176412,R-HSA-176814,R-HSA-179409,R-HSA-179419,R-HSA-212436,R-HSA-2262752,R-HSA-2467813,R-HSA-2555396,R-HSA-2559582,R-HSA-2559583,R-HSA-453276,R-HSA-68867,R-HSA-68882,R-HSA-68886,R-HSA-69002,R-HSA-69017,R-HSA-69052,R-HSA-69239,R-HSA-69242,R-HSA-69278,R-HSA-69306,R-HSA-69618,R-HSA-69620,R-HSA-73857,R-HSA-74160,R-HSA-8853884,R-HSA-8953897,R-HSA-9675126,R-HSA-9687136,R-HSA-9687139,R-HSA-983168,R-HSA-983169","Adaptive Immune System|Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components|Inactivation of APC/C via direct inhibition of the APC/C complex|Cell Cycle|Disease|Immune System|APC/C:Cdc20 mediated degradation of Cyclin B|Autodegradation of Cdh1 by Cdh1:APC/C|APC/C-mediated degradation of cell cycle proteins|APC/C:Cdc20 mediated degradation of Securin|APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1|Cdc20:Phospho-APC/C mediated degradation of Cyclin A|Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase|Regulation of APC/C activators between G1/S and early anaphase|APC/C:Cdc20 mediated degradation of mitotic proteins|Phosphorylation of the APC/C|Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins|APC-Cdc20 mediated degradation of Nek2A|APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint|Generic Transcription Pathway|Cellular responses to stress|Separation of Sister Chromatids|Mitotic Metaphase and Anaphase|Senescence-Associated Secretory Phenotype (SASP)|Cellular Senescence|Regulation of mitotic cell cycle|Assembly of the pre-replicative complex|Mitotic Anaphase|M Phase|DNA Replication Pre-Initiation|CDK-mediated phosphorylation and removal of Cdc6|Switching of origins to a post-replicative state|Synthesis of DNA|S Phase|Cell Cycle, Mitotic|DNA Replication|Mitotic Spindle Checkpoint|Cell Cycle Checkpoints|RNA Polymerase II Transcription|Gene expression (Transcription)|Transcriptional Regulation by VENTX|Cellular responses to stimuli|Diseases of mitotic cell cycle|Aberrant regulation of mitotic exit in cancer due to RB1 defects|Aberrant regulation of mitotic cell cycle due to RB1 defects|Antigen processing: Ubiquitination & Proteasome degradation|Class I MHC mediated antigen processing & presentation"]
["ANAPC10",2.40796707799129,1.98705611112585,1.97351749916306,1.66649895445615,2.06043339879398,2.01063797194783,2.24053961517687,1.8634690345367,2.14714869243408,1.07810573134827,1.45053853157818,1.37499767397045,1.99288005298165,1.65042346106582,1.72494009479693,1.58584181410351,2.27757208726838,2.26413697500721,2.99539533804411,2.01515624687113,2.62903495125541,2.44351425905245,3.50154194601443,2.97561724591784,2.83896856450128,2.33747214670416,3.52040903591829,2.73487607003524,10393,"anaphase promoting complex subunit 10","protein_coding","hsa04120,hsa04110,hsa04114,hsa04914,hsa05166","Ubiquitin mediated proteolysis|Cell cycle|Oocyte meiosis|Progesterone-mediated oocyte maturation|Human T-cell leukemia virus 1 infection","GO:0005515,GO:0005654,GO:0005680,GO:0005829,GO:0007049,GO:0007346,GO:0031145,GO:0051301,GO:0051445,GO:0070979","protein binding|nucleoplasm|anaphase-promoting complex|cytosol|cell cycle|regulation of mitotic cell cycle|anaphase-promoting complex-dependent catabolic process|cell division|regulation of meiotic cell cycle|protein K11-linked ubiquitination","WP179","Cell cycle","R-HSA-1280218,R-HSA-141405,R-HSA-141430,R-HSA-1640170,R-HSA-1643685,R-HSA-168256,R-HSA-174048,R-HSA-174084,R-HSA-174143,R-HSA-174154,R-HSA-174178,R-HSA-174184,R-HSA-176407,R-HSA-176408,R-HSA-176409,R-HSA-176412,R-HSA-176814,R-HSA-179409,R-HSA-179419,R-HSA-212436,R-HSA-2262752,R-HSA-2467813,R-HSA-2555396,R-HSA-2559582,R-HSA-2559583,R-HSA-453276,R-HSA-68867,R-HSA-68882,R-HSA-68886,R-HSA-69002,R-HSA-69017,R-HSA-69052,R-HSA-69239,R-HSA-69242,R-HSA-69278,R-HSA-69306,R-HSA-69618,R-HSA-69620,R-HSA-73857,R-HSA-74160,R-HSA-8853884,R-HSA-8953897,R-HSA-9675126,R-HSA-9687136,R-HSA-9687139,R-HSA-983168,R-HSA-983169","Adaptive Immune System|Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components|Inactivation of APC/C via direct inhibition of the APC/C complex|Cell Cycle|Disease|Immune System|APC/C:Cdc20 mediated degradation of Cyclin B|Autodegradation of Cdh1 by Cdh1:APC/C|APC/C-mediated degradation of cell cycle proteins|APC/C:Cdc20 mediated degradation of Securin|APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1|Cdc20:Phospho-APC/C mediated degradation of Cyclin A|Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase|Regulation of APC/C activators between G1/S and early anaphase|APC/C:Cdc20 mediated degradation of mitotic proteins|Phosphorylation of the APC/C|Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins|APC-Cdc20 mediated degradation of Nek2A|APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint|Generic Transcription Pathway|Cellular responses to stress|Separation of Sister Chromatids|Mitotic Metaphase and Anaphase|Senescence-Associated Secretory Phenotype (SASP)|Cellular Senescence|Regulation of mitotic cell cycle|Assembly of the pre-replicative complex|Mitotic Anaphase|M Phase|DNA Replication Pre-Initiation|CDK-mediated phosphorylation and removal of Cdc6|Switching of origins to a post-replicative state|Synthesis of DNA|S Phase|Cell Cycle, Mitotic|DNA Replication|Mitotic Spindle Checkpoint|Cell Cycle Checkpoints|RNA Polymerase II Transcription|Gene expression (Transcription)|Transcriptional Regulation by VENTX|Cellular responses to stimuli|Diseases of mitotic cell cycle|Aberrant regulation of mitotic exit in cancer due to RB1 defects|Aberrant regulation of mitotic cell cycle due to RB1 defects|Antigen processing: Ubiquitination & Proteasome degradation|Class I MHC mediated antigen processing & presentation"]
["ANAPC11",51.2938267047769,41.3493180778312,58.6008288941026,53.5435642100799,37.3282214140311,42.590564136616,60.3757411113738,55.3670240415903,52.1110992625931,46.9464145403044,62.5801668052617,60.4565046819987,48.6009354428427,49.8814106786508,54.99291555556,48.3260135447641,82.0286278973421,76.8044046771823,101.61548058508,67.2317554135795,69.2525246800835,78.6256255299016,89.3477898158633,87.2164354844639,71.0291581910128,80.51505750616,108.811857761765,87.0154453843556,51529,"anaphase promoting complex subunit 11","protein_coding","hsa04120,hsa04110,hsa04114,hsa04914,hsa05166","Ubiquitin mediated proteolysis|Cell cycle|Oocyte meiosis|Progesterone-mediated oocyte maturation|Human T-cell leukemia virus 1 infection","GO:0000278,GO:0004842,GO:0005515,GO:0005634,GO:0005654,GO:0005680,GO:0005730,GO:0005829,GO:0006511,GO:0007346,GO:0008270,GO:0016567,GO:0031145,GO:0034450,GO:0045842,GO:0051301,GO:0051445,GO:0061630,GO:0070979,GO:0097602","mitotic cell cycle|ubiquitin-protein transferase activity|protein binding|nucleus|nucleoplasm|anaphase-promoting complex|nucleolus|cytosol|ubiquitin-dependent protein catabolic process|regulation of mitotic cell cycle|zinc ion binding|protein ubiquitination|anaphase-promoting complex-dependent catabolic process|ubiquitin-ubiquitin ligase activity|positive regulation of mitotic metaphase/anaphase transition|cell division|regulation of meiotic cell cycle|ubiquitin protein ligase activity|protein K11-linked ubiquitination|cullin family protein binding","WP179,WP4240","Cell cycle|Regulation of sister chromatid separation at the metaphase-anaphase transition","R-HSA-1280218,R-HSA-141405,R-HSA-141430,R-HSA-1640170,R-HSA-1643685,R-HSA-168256,R-HSA-174048,R-HSA-174084,R-HSA-174143,R-HSA-174154,R-HSA-174178,R-HSA-174184,R-HSA-176407,R-HSA-176408,R-HSA-176409,R-HSA-176412,R-HSA-176814,R-HSA-179409,R-HSA-179419,R-HSA-212436,R-HSA-2262752,R-HSA-2467813,R-HSA-2555396,R-HSA-2559582,R-HSA-2559583,R-HSA-453276,R-HSA-68867,R-HSA-68882,R-HSA-68886,R-HSA-69002,R-HSA-69017,R-HSA-69052,R-HSA-69239,R-HSA-69242,R-HSA-69278,R-HSA-69306,R-HSA-69618,R-HSA-69620,R-HSA-73857,R-HSA-74160,R-HSA-8853884,R-HSA-8953897,R-HSA-9675126,R-HSA-9687136,R-HSA-9687139,R-HSA-983168,R-HSA-983169","Adaptive Immune System|Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components|Inactivation of APC/C via direct inhibition of the APC/C complex|Cell Cycle|Disease|Immune System|APC/C:Cdc20 mediated degradation of Cyclin B|Autodegradation of Cdh1 by Cdh1:APC/C|APC/C-mediated degradation of cell cycle proteins|APC/C:Cdc20 mediated degradation of Securin|APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1|Cdc20:Phospho-APC/C mediated degradation of Cyclin A|Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase|Regulation of APC/C activators between G1/S and early anaphase|APC/C:Cdc20 mediated degradation of mitotic proteins|Phosphorylation of the APC/C|Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins|APC-Cdc20 mediated degradation of Nek2A|APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint|Generic Transcription Pathway|Cellular responses to stress|Separation of Sister Chromatids|Mitotic Metaphase and Anaphase|Senescence-Associated Secretory Phenotype (SASP)|Cellular Senescence|Regulation of mitotic cell cycle|Assembly of the pre-replicative complex|Mitotic Anaphase|M Phase|DNA Replication Pre-Initiation|CDK-mediated phosphorylation and removal of Cdc6|Switching of origins to a post-replicative state|Synthesis of DNA|S Phase|Cell Cycle, Mitotic|DNA Replication|Mitotic Spindle Checkpoint|Cell Cycle Checkpoints|RNA Polymerase II Transcription|Gene expression (Transcription)|Transcriptional Regulation by VENTX|Cellular responses to stimuli|Diseases of mitotic cell cycle|Aberrant regulation of mitotic exit in cancer due to RB1 defects|Aberrant regulation of mitotic cell cycle due to RB1 defects|Antigen processing: Ubiquitination & Proteasome degradation|Class I MHC mediated antigen processing & presentation"]
["ANAPC13",43.9172648865171,37.4018628840471,35.4881478787036,39.2420258868663,42.0132067178559,35.6886730428158,36.100081341345,39.1044610149853,35.2103158726533,24.2568413044462,33.0715967016812,32.0083050379585,38.3413464796311,31.3499818019717,31.9556546030814,31.5805338960403,36.8350156703014,32.8492998479107,39.9400608716056,36.0116987167075,40.9265099164358,33.2735720088245,48.6292320554629,42.1482125904585,36.2137047851078,40.032874793209,46.8312751053632,36.1969055745848,25847,"anaphase promoting complex subunit 13","protein_coding","hsa04120,hsa04110,hsa04114,hsa04914,hsa05166","Ubiquitin mediated proteolysis|Cell cycle|Oocyte meiosis|Progesterone-mediated oocyte maturation|Human T-cell leukemia virus 1 infection","GO:0005515,GO:0005680,GO:0007049,GO:0007346,GO:0031145,GO:0051301,GO:0051445,GO:0070979","protein binding|anaphase-promoting complex|cell cycle|regulation of mitotic cell cycle|anaphase-promoting complex-dependent catabolic process|cell division|regulation of meiotic cell cycle|protein K11-linked ubiquitination","WP179","Cell cycle","R-HSA-1280218,R-HSA-168256,R-HSA-983168,R-HSA-983169","Adaptive Immune System|Immune System|Antigen processing: Ubiquitination & Proteasome degradation|Class I MHC mediated antigen processing & presentation"]
["ANAPC15",7.08922733652204,7.16447084976576,9.42655908581272,8.03266779511448,5.82395528531308,6.81149488714238,9.18784984538351,8.3532214472654,7.01578877645009,8.47284714051216,8.68324086020633,8.47685753550654,6.57868445962371,7.03805220593956,7.39712115519548,6.53193998521994,10.7528478430233,11.955058037998,16.6904658760607,10.8579628381187,10.4010066726358,11.6634353844643,13.4116854239761,11.904029867268,9.96165824652647,13.8183907323279,14.8059540401841,14.2632512591712,25906,"anaphase promoting complex subunit 15","protein_coding","hsa04120,hsa04110,hsa04114,hsa04914,hsa05166","Ubiquitin mediated proteolysis|Cell cycle|Oocyte meiosis|Progesterone-mediated oocyte maturation|Human T-cell leukemia virus 1 infection","GO:0005515,GO:0005654,GO:0005680,GO:0005829,GO:0007049,GO:0007346,GO:0031145,GO:0051301,GO:0051445,GO:0090266","protein binding|nucleoplasm|anaphase-promoting complex|cytosol|cell cycle|regulation of mitotic cell cycle|anaphase-promoting complex-dependent catabolic process|cell division|regulation of meiotic cell cycle|regulation of mitotic cell cycle spindle assembly checkpoint",null,null,"R-HSA-141405,R-HSA-141430,R-HSA-1640170,R-HSA-1643685,R-HSA-174048,R-HSA-174084,R-HSA-174143,R-HSA-174154,R-HSA-174178,R-HSA-174184,R-HSA-176407,R-HSA-176408,R-HSA-176409,R-HSA-176412,R-HSA-176814,R-HSA-179409,R-HSA-179419,R-HSA-212436,R-HSA-2262752,R-HSA-2467813,R-HSA-2555396,R-HSA-2559582,R-HSA-2559583,R-HSA-453276,R-HSA-68867,R-HSA-68882,R-HSA-68886,R-HSA-69002,R-HSA-69017,R-HSA-69052,R-HSA-69239,R-HSA-69242,R-HSA-69278,R-HSA-69306,R-HSA-69618,R-HSA-69620,R-HSA-73857,R-HSA-74160,R-HSA-8853884,R-HSA-8953897,R-HSA-9675126,R-HSA-9687136,R-HSA-9687139","Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components|Inactivation of APC/C via direct inhibition of the APC/C complex|Cell Cycle|Disease|APC/C:Cdc20 mediated degradation of Cyclin B|Autodegradation of Cdh1 by Cdh1:APC/C|APC/C-mediated degradation of cell cycle proteins|APC/C:Cdc20 mediated degradation of Securin|APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1|Cdc20:Phospho-APC/C mediated degradation of Cyclin A|Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase|Regulation of APC/C activators between G1/S and early anaphase|APC/C:Cdc20 mediated degradation of mitotic proteins|Phosphorylation of the APC/C|Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins|APC-Cdc20 mediated degradation of Nek2A|APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint|Generic Transcription Pathway|Cellular responses to stress|Separation of Sister Chromatids|Mitotic Metaphase and Anaphase|Senescence-Associated Secretory Phenotype (SASP)|Cellular Senescence|Regulation of mitotic cell cycle|Assembly of the pre-replicative complex|Mitotic Anaphase|M Phase|DNA Replication Pre-Initiation|CDK-mediated phosphorylation and removal of Cdc6|Switching of origins to a post-replicative state|Synthesis of DNA|S Phase|Cell Cycle, Mitotic|DNA Replication|Mitotic Spindle Checkpoint|Cell Cycle Checkpoints|RNA Polymerase II Transcription|Gene expression (Transcription)|Transcriptional Regulation by VENTX|Cellular responses to stimuli|Diseases of mitotic cell cycle|Aberrant regulation of mitotic exit in cancer due to RB1 defects|Aberrant regulation of mitotic cell cycle due to RB1 defects"]
["ANAPC16",12.1158995346573,12.55656573854,16.2685861146307,12.8165347870799,11.6659967824054,13.2979546231424,16.5599486548916,15.877284332989,14.2812368871969,11.1358385865245,13.1718421102138,13.7940829764741,13.2212911845,15.5351105006212,16.7058865450511,14.4838992001771,14.3603456176367,13.3896487751392,17.0593734705718,13.3477776769536,14.3345856556912,15.2361720135081,18.6085231635521,17.3117398571402,14.0615609500446,13.9045377796962,19.376229328701,15.187129890805,119504,"anaphase promoting complex subunit 16","protein_coding","hsa04120,hsa04110,hsa04114,hsa04914,hsa05166","Ubiquitin mediated proteolysis|Cell cycle|Oocyte meiosis|Progesterone-mediated oocyte maturation|Human T-cell leukemia virus 1 infection","GO:0000776,GO:0005515,GO:0005654,GO:0005680,GO:0005829,GO:0007049,GO:0007346,GO:0016567,GO:0031145,GO:0051301,GO:0051445","kinetochore|protein binding|nucleoplasm|anaphase-promoting complex|cytosol|cell cycle|regulation of mitotic cell cycle|protein ubiquitination|anaphase-promoting complex-dependent catabolic process|cell division|regulation of meiotic cell cycle",null,null,"R-HSA-141405,R-HSA-141430,R-HSA-1640170,R-HSA-1643685,R-HSA-174048,R-HSA-174084,R-HSA-174143,R-HSA-174154,R-HSA-174178,R-HSA-174184,R-HSA-176407,R-HSA-176408,R-HSA-176409,R-HSA-176412,R-HSA-176814,R-HSA-179409,R-HSA-179419,R-HSA-212436,R-HSA-2262752,R-HSA-2467813,R-HSA-2555396,R-HSA-2559582,R-HSA-2559583,R-HSA-453276,R-HSA-68867,R-HSA-68882,R-HSA-68886,R-HSA-69002,R-HSA-69017,R-HSA-69052,R-HSA-69239,R-HSA-69242,R-HSA-69278,R-HSA-69306,R-HSA-69618,R-HSA-69620,R-HSA-73857,R-HSA-74160,R-HSA-8853884,R-HSA-8953897,R-HSA-9675126,R-HSA-9687136,R-HSA-9687139","Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components|Inactivation of APC/C via direct inhibition of the APC/C complex|Cell Cycle|Disease|APC/C:Cdc20 mediated degradation of Cyclin B|Autodegradation of Cdh1 by Cdh1:APC/C|APC/C-mediated degradation of cell cycle proteins|APC/C:Cdc20 mediated degradation of Securin|APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1|Cdc20:Phospho-APC/C mediated degradation of Cyclin A|Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase|Regulation of APC/C activators between G1/S and early anaphase|APC/C:Cdc20 mediated degradation of mitotic proteins|Phosphorylation of the APC/C|Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins|APC-Cdc20 mediated degradation of Nek2A|APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint|Generic Transcription Pathway|Cellular responses to stress|Separation of Sister Chromatids|Mitotic Metaphase and Anaphase|Senescence-Associated Secretory Phenotype (SASP)|Cellular Senescence|Regulation of mitotic cell cycle|Assembly of the pre-replicative complex|Mitotic Anaphase|M Phase|DNA Replication Pre-Initiation|CDK-mediated phosphorylation and removal of Cdc6|Switching of origins to a post-replicative state|Synthesis of DNA|S Phase|Cell Cycle, Mitotic|DNA Replication|Mitotic Spindle Checkpoint|Cell Cycle Checkpoints|RNA Polymerase II Transcription|Gene expression (Transcription)|Transcriptional Regulation by VENTX|Cellular responses to stimuli|Diseases of mitotic cell cycle|Aberrant regulation of mitotic exit in cancer due to RB1 defects|Aberrant regulation of mitotic cell cycle due to RB1 defects"]
["ANAPC2",13.1481351147419,14.6306392037702,15.0033678192715,14.7520367677076,12.788277664586,13.9008409842757,13.43222818534,14.3963763376929,12.7044019748439,18.9901197171044,18.2086264273261,15.0872029772575,12.8706656094873,14.1225985169092,14.2672144970727,13.2750625703636,13.0706412335614,15.2186257039882,14.8824200753473,14.6645369877056,14.2018971631061,14.4955027901641,12.7495692280642,13.5297930423608,14.3841997413635,15.1750082708908,12.6937342517014,15.7301514697925,29882,"anaphase promoting complex subunit 2","protein_coding","hsa04120,hsa04110,hsa04114,hsa04914,hsa05166","Ubiquitin mediated proteolysis|Cell cycle|Oocyte meiosis|Progesterone-mediated oocyte maturation|Human T-cell leukemia virus 1 infection","GO:0005515,GO:0005654,GO:0005680,GO:0005829,GO:0007091,GO:0007346,GO:0007399,GO:0010629,GO:0030154,GO:0031145,GO:0031625,GO:0031915,GO:0045773,GO:0050775,GO:0051301,GO:0051445,GO:0070979,GO:0090129","protein binding|nucleoplasm|anaphase-promoting complex|cytosol|metaphase/anaphase transition of mitotic cell cycle|regulation of mitotic cell cycle|nervous system development|negative regulation of gene expression|cell differentiation|anaphase-promoting complex-dependent catabolic process|ubiquitin protein ligase binding|positive regulation of synaptic plasticity|positive regulation of axon extension|positive regulation of dendrite morphogenesis|cell division|regulation of meiotic cell cycle|protein K11-linked ubiquitination|positive regulation of synapse maturation","WP179,WP4240","Cell cycle|Regulation of sister chromatid separation at the metaphase-anaphase transition","R-HSA-1280218,R-HSA-141405,R-HSA-141430,R-HSA-1640170,R-HSA-1643685,R-HSA-168256,R-HSA-174048,R-HSA-174084,R-HSA-174143,R-HSA-174154,R-HSA-174178,R-HSA-174184,R-HSA-176407,R-HSA-176408,R-HSA-176409,R-HSA-176412,R-HSA-176814,R-HSA-179409,R-HSA-179419,R-HSA-212436,R-HSA-2262752,R-HSA-2467813,R-HSA-2555396,R-HSA-2559582,R-HSA-2559583,R-HSA-453276,R-HSA-68867,R-HSA-68882,R-HSA-68886,R-HSA-69002,R-HSA-69017,R-HSA-69052,R-HSA-69239,R-HSA-69242,R-HSA-69278,R-HSA-69306,R-HSA-69618,R-HSA-69620,R-HSA-73857,R-HSA-74160,R-HSA-8853884,R-HSA-8953897,R-HSA-9675126,R-HSA-9687136,R-HSA-9687139,R-HSA-983168,R-HSA-983169","Adaptive Immune System|Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components|Inactivation of APC/C via direct inhibition of the APC/C complex|Cell Cycle|Disease|Immune System|APC/C:Cdc20 mediated degradation of Cyclin B|Autodegradation of Cdh1 by Cdh1:APC/C|APC/C-mediated degradation of cell cycle proteins|APC/C:Cdc20 mediated degradation of Securin|APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1|Cdc20:Phospho-APC/C mediated degradation of Cyclin A|Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase|Regulation of APC/C activators between G1/S and early anaphase|APC/C:Cdc20 mediated degradation of mitotic proteins|Phosphorylation of the APC/C|Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins|APC-Cdc20 mediated degradation of Nek2A|APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint|Generic Transcription Pathway|Cellular responses to stress|Separation of Sister Chromatids|Mitotic Metaphase and Anaphase|Senescence-Associated Secretory Phenotype (SASP)|Cellular Senescence|Regulation of mitotic cell cycle|Assembly of the pre-replicative complex|Mitotic Anaphase|M Phase|DNA Replication Pre-Initiation|CDK-mediated phosphorylation and removal of Cdc6|Switching of origins to a post-replicative state|Synthesis of DNA|S Phase|Cell Cycle, Mitotic|DNA Replication|Mitotic Spindle Checkpoint|Cell Cycle Checkpoints|RNA Polymerase II Transcription|Gene expression (Transcription)|Transcriptional Regulation by VENTX|Cellular responses to stimuli|Diseases of mitotic cell cycle|Aberrant regulation of mitotic exit in cancer due to RB1 defects|Aberrant regulation of mitotic cell cycle due to RB1 defects|Antigen processing: Ubiquitination & Proteasome degradation|Class I MHC mediated antigen processing & presentation"]
["ANAPC4",9.52329488193083,8.15241011919872,8.65106162297403,8.16931357221438,8.74569381834826,7.29505459562217,7.84032051989405,7.45351707375617,7.32627101757181,4.67949688576684,6.46830041625642,7.32786351694583,7.42135514643436,6.75903128342278,7.15909386547126,6.34575313741724,7.34181261616579,7.50615166659836,9.11946895301847,7.44495411127127,7.50712736574104,7.83689537358174,9.34065235896581,8.20991707476738,7.95543543334935,8.32828703821288,9.47150414732993,6.9137048376592,29945,"anaphase promoting complex subunit 4","protein_coding","hsa04120,hsa04110,hsa04114,hsa04914,hsa05166","Ubiquitin mediated proteolysis|Cell cycle|Oocyte meiosis|Progesterone-mediated oocyte maturation|Human T-cell leukemia virus 1 infection","GO:0004842,GO:0005515,GO:0005634,GO:0005654,GO:0005680,GO:0005829,GO:0007049,GO:0007346,GO:0019903,GO:0030071,GO:0031145,GO:0034399,GO:0051301,GO:0051445,GO:0070979","ubiquitin-protein transferase activity|protein binding|nucleus|nucleoplasm|anaphase-promoting complex|cytosol|cell cycle|regulation of mitotic cell cycle|protein phosphatase binding|regulation of mitotic metaphase/anaphase transition|anaphase-promoting complex-dependent catabolic process|nuclear periphery|cell division|regulation of meiotic cell cycle|protein K11-linked ubiquitination","WP179","Cell cycle","R-HSA-1280218,R-HSA-141405,R-HSA-141430,R-HSA-1640170,R-HSA-1643685,R-HSA-168256,R-HSA-174048,R-HSA-174084,R-HSA-174143,R-HSA-174154,R-HSA-174178,R-HSA-174184,R-HSA-176407,R-HSA-176408,R-HSA-176409,R-HSA-176412,R-HSA-176814,R-HSA-179409,R-HSA-179419,R-HSA-212436,R-HSA-2262752,R-HSA-2467813,R-HSA-2555396,R-HSA-2559582,R-HSA-2559583,R-HSA-453276,R-HSA-68867,R-HSA-68882,R-HSA-68886,R-HSA-69002,R-HSA-69017,R-HSA-69052,R-HSA-69239,R-HSA-69242,R-HSA-69278,R-HSA-69306,R-HSA-69618,R-HSA-69620,R-HSA-73857,R-HSA-74160,R-HSA-8853884,R-HSA-8953897,R-HSA-9675126,R-HSA-9687136,R-HSA-9687139,R-HSA-983168,R-HSA-983169","Adaptive Immune System|Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components|Inactivation of APC/C via direct inhibition of the APC/C complex|Cell Cycle|Disease|Immune System|APC/C:Cdc20 mediated degradation of Cyclin B|Autodegradation of Cdh1 by Cdh1:APC/C|APC/C-mediated degradation of cell cycle proteins|APC/C:Cdc20 mediated degradation of Securin|APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1|Cdc20:Phospho-APC/C mediated degradation of Cyclin A|Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase|Regulation of APC/C activators between G1/S and early anaphase|APC/C:Cdc20 mediated degradation of mitotic proteins|Phosphorylation of the APC/C|Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins|APC-Cdc20 mediated degradation of Nek2A|APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint|Generic Transcription Pathway|Cellular responses to stress|Separation of Sister Chromatids|Mitotic Metaphase and Anaphase|Senescence-Associated Secretory Phenotype (SASP)|Cellular Senescence|Regulation of mitotic cell cycle|Assembly of the pre-replicative complex|Mitotic Anaphase|M Phase|DNA Replication Pre-Initiation|CDK-mediated phosphorylation and removal of Cdc6|Switching of origins to a post-replicative state|Synthesis of DNA|S Phase|Cell Cycle, Mitotic|DNA Replication|Mitotic Spindle Checkpoint|Cell Cycle Checkpoints|RNA Polymerase II Transcription|Gene expression (Transcription)|Transcriptional Regulation by VENTX|Cellular responses to stimuli|Diseases of mitotic cell cycle|Aberrant regulation of mitotic exit in cancer due to RB1 defects|Aberrant regulation of mitotic cell cycle due to RB1 defects|Antigen processing: Ubiquitination & Proteasome degradation|Class I MHC mediated antigen processing & presentation"]
["ANAPC5",43.0937480411234,40.6354534398538,40.7411398896929,43.180846714894,37.7766285208428,39.2775683845239,39.3336640312997,39.4673711383854,40.5146883620421,39.2194240563232,41.0945213433884,42.9613787191028,40.0925271109948,38.5156263577188,37.000576257971,36.1690705403488,50.1128406522229,48.6738689058055,48.9999750255871,46.0324738937983,45.5045142636126,48.2447887250686,50.1463645377147,46.335128401138,44.7676443691228,49.4973009178557,50.4576607132333,48.037242488037,51433,"anaphase promoting complex subunit 5","protein_coding","hsa04120,hsa04110,hsa04114,hsa04657,hsa04914,hsa05166","Ubiquitin mediated proteolysis|Cell cycle|Oocyte meiosis|IL-17 signaling pathway|Progesterone-mediated oocyte maturation|Human T-cell leukemia virus 1 infection","GO:0005634,GO:0005654,GO:0005680,GO:0005819,GO:0005829,GO:0007049,GO:0007346,GO:0019903,GO:0031145,GO:0045842,GO:0051301,GO:0051445,GO:0070979","nucleus|nucleoplasm|anaphase-promoting complex|spindle|cytosol|cell cycle|regulation of mitotic cell cycle|protein phosphatase binding|anaphase-promoting complex-dependent catabolic process|positive regulation of mitotic metaphase/anaphase transition|cell division|regulation of meiotic cell cycle|protein K11-linked ubiquitination","WP179","Cell cycle","R-HSA-1280218,R-HSA-141405,R-HSA-141430,R-HSA-1640170,R-HSA-1643685,R-HSA-168256,R-HSA-174048,R-HSA-174084,R-HSA-174143,R-HSA-174154,R-HSA-174178,R-HSA-174184,R-HSA-176407,R-HSA-176408,R-HSA-176409,R-HSA-176412,R-HSA-176814,R-HSA-179409,R-HSA-179419,R-HSA-212436,R-HSA-2262752,R-HSA-2467813,R-HSA-2555396,R-HSA-2559582,R-HSA-2559583,R-HSA-453276,R-HSA-68867,R-HSA-68882,R-HSA-68886,R-HSA-69002,R-HSA-69017,R-HSA-69052,R-HSA-69239,R-HSA-69242,R-HSA-69278,R-HSA-69306,R-HSA-69618,R-HSA-69620,R-HSA-73857,R-HSA-74160,R-HSA-8853884,R-HSA-8953897,R-HSA-9675126,R-HSA-9687136,R-HSA-9687139,R-HSA-983168,R-HSA-983169","Adaptive Immune System|Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components|Inactivation of APC/C via direct inhibition of the APC/C complex|Cell Cycle|Disease|Immune System|APC/C:Cdc20 mediated degradation of Cyclin B|Autodegradation of Cdh1 by Cdh1:APC/C|APC/C-mediated degradation of cell cycle proteins|APC/C:Cdc20 mediated degradation of Securin|APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1|Cdc20:Phospho-APC/C mediated degradation of Cyclin A|Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase|Regulation of APC/C activators between G1/S and early anaphase|APC/C:Cdc20 mediated degradation of mitotic proteins|Phosphorylation of the APC/C|Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins|APC-Cdc20 mediated degradation of Nek2A|APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint|Generic Transcription Pathway|Cellular responses to stress|Separation of Sister Chromatids|Mitotic Metaphase and Anaphase|Senescence-Associated Secretory Phenotype (SASP)|Cellular Senescence|Regulation of mitotic cell cycle|Assembly of the pre-replicative complex|Mitotic Anaphase|M Phase|DNA Replication Pre-Initiation|CDK-mediated phosphorylation and removal of Cdc6|Switching of origins to a post-replicative state|Synthesis of DNA|S Phase|Cell Cycle, Mitotic|DNA Replication|Mitotic Spindle Checkpoint|Cell Cycle Checkpoints|RNA Polymerase II Transcription|Gene expression (Transcription)|Transcriptional Regulation by VENTX|Cellular responses to stimuli|Diseases of mitotic cell cycle|Aberrant regulation of mitotic exit in cancer due to RB1 defects|Aberrant regulation of mitotic cell cycle due to RB1 defects|Antigen processing: Ubiquitination & Proteasome degradation|Class I MHC mediated antigen processing & presentation"]
["ANAPC7",11.4950846068949,10.1669912193947,10.8172236017546,11.2099999894363,10.9279378838159,10.1838433633966,10.6897125747664,9.81231704834737,10.6813902894314,9.24414883476453,10.2595787265792,10.3106472404228,8.49393385653233,8.46401377840055,9.78075881024507,9.28893613238612,11.036327082213,11.6702593761539,11.2051188877692,11.3433137550619,11.3974640216356,10.5893584854759,12.1599002125228,11.0361219915534,11.0075531493509,10.7896338867336,11.7632272331265,10.8622840318073,51434,"anaphase promoting complex subunit 7","protein_coding","hsa04120,hsa04110,hsa04114,hsa04914,hsa05166","Ubiquitin mediated proteolysis|Cell cycle|Oocyte meiosis|Progesterone-mediated oocyte maturation|Human T-cell leukemia virus 1 infection","GO:0000792,GO:0005634,GO:0005654,GO:0005680,GO:0005819,GO:0005829,GO:0007049,GO:0007346,GO:0007420,GO:0015630,GO:0016567,GO:0019903,GO:0031145,GO:0045842,GO:0051301,GO:0051445,GO:0070979,GO:0140767","heterochromatin|nucleus|nucleoplasm|anaphase-promoting complex|spindle|cytosol|cell cycle|regulation of mitotic cell cycle|brain development|microtubule cytoskeleton|protein ubiquitination|protein phosphatase binding|anaphase-promoting complex-dependent catabolic process|positive regulation of mitotic metaphase/anaphase transition|cell division|regulation of meiotic cell cycle|protein K11-linked ubiquitination|enzyme-substrate adaptor activity","WP179","Cell cycle","R-HSA-1280218,R-HSA-141405,R-HSA-141430,R-HSA-1640170,R-HSA-1643685,R-HSA-168256,R-HSA-174048,R-HSA-174084,R-HSA-174143,R-HSA-174154,R-HSA-174178,R-HSA-174184,R-HSA-176407,R-HSA-176408,R-HSA-176409,R-HSA-176412,R-HSA-176814,R-HSA-179409,R-HSA-179419,R-HSA-212436,R-HSA-2262752,R-HSA-2467813,R-HSA-2555396,R-HSA-2559582,R-HSA-2559583,R-HSA-453276,R-HSA-68867,R-HSA-68882,R-HSA-68886,R-HSA-69002,R-HSA-69017,R-HSA-69052,R-HSA-69239,R-HSA-69242,R-HSA-69278,R-HSA-69306,R-HSA-69618,R-HSA-69620,R-HSA-73857,R-HSA-74160,R-HSA-8853884,R-HSA-8953897,R-HSA-9675126,R-HSA-9687136,R-HSA-9687139,R-HSA-983168,R-HSA-983169","Adaptive Immune System|Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components|Inactivation of APC/C via direct inhibition of the APC/C complex|Cell Cycle|Disease|Immune System|APC/C:Cdc20 mediated degradation of Cyclin B|Autodegradation of Cdh1 by Cdh1:APC/C|APC/C-mediated degradation of cell cycle proteins|APC/C:Cdc20 mediated degradation of Securin|APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1|Cdc20:Phospho-APC/C mediated degradation of Cyclin A|Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase|Regulation of APC/C activators between G1/S and early anaphase|APC/C:Cdc20 mediated degradation of mitotic proteins|Phosphorylation of the APC/C|Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins|APC-Cdc20 mediated degradation of Nek2A|APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint|Generic Transcription Pathway|Cellular responses to stress|Separation of Sister Chromatids|Mitotic Metaphase and Anaphase|Senescence-Associated Secretory Phenotype (SASP)|Cellular Senescence|Regulation of mitotic cell cycle|Assembly of the pre-replicative complex|Mitotic Anaphase|M Phase|DNA Replication Pre-Initiation|CDK-mediated phosphorylation and removal of Cdc6|Switching of origins to a post-replicative state|Synthesis of DNA|S Phase|Cell Cycle, Mitotic|DNA Replication|Mitotic Spindle Checkpoint|Cell Cycle Checkpoints|RNA Polymerase II Transcription|Gene expression (Transcription)|Transcriptional Regulation by VENTX|Cellular responses to stimuli|Diseases of mitotic cell cycle|Aberrant regulation of mitotic exit in cancer due to RB1 defects|Aberrant regulation of mitotic cell cycle due to RB1 defects|Antigen processing: Ubiquitination & Proteasome degradation|Class I MHC mediated antigen processing & presentation"]
["ANG",1.3505859383478,1.74217122371117,2.11908722224316,1.43724016620769,1.04855715276755,1.45937805396829,2.00232602906306,2.01378383584365,1.7679192522764,1.96009055448796,2.26190738646715,1.78691726344484,1.98817347241598,2.46940504126526,1.22162538491269,1.89452804989146,2.09895582350635,2.89302442031699,2.92396022087052,2.3662195445714,2.61935518382893,2.4268750187525,2.84929864872663,2.34976867089752,2.75137450727623,2.60175802544911,3.473230386149,3.478649451951,283,"angiogenin","protein_coding","hsa05014","Amyotrophic lateral sclerosis","GO:0001525,GO:0001541,GO:0001556,GO:0001666,GO:0001890,GO:0001938,GO:0003677,GO:0003779,GO:0004519,GO:0004521,GO:0004540,GO:0005102,GO:0005507,GO:0005515,GO:0005576,GO:0005604,GO:0005615,GO:0005634,GO:0005694,GO:0005730,GO:0005829,GO:0006651,GO:0007154,GO:0007202,GO:0008201,GO:0009303,GO:0009725,GO:0015629,GO:0016078,GO:0016477,GO:0017148,GO:0019731,GO:0019843,GO:0030041,GO:0030426,GO:0031410,GO:0032148,GO:0032311,GO:0032431,GO:0042277,GO:0042327,GO:0042592,GO:0042803,GO:0043025,GO:0045087,GO:0048662,GO:0050714,GO:0050830,GO:0061844","angiogenesis|ovarian follicle development|oocyte maturation|response to hypoxia|placenta development|positive regulation of endothelial cell proliferation|DNA binding|actin binding|endonuclease activity|RNA endonuclease activity|RNA nuclease activity|signaling receptor binding|copper ion binding|protein binding|extracellular region|basement membrane|extracellular space|nucleus|chromosome|nucleolus|cytosol|diacylglycerol biosynthetic process|cell communication|activation of phospholipase C activity|heparin binding|rRNA transcription|response to hormone|actin cytoskeleton|tRNA catabolic process|cell migration|negative regulation of translation|antibacterial humoral response|rRNA binding|actin filament polymerization|growth cone|cytoplasmic vesicle|activation of protein kinase B activity|angiogenin-PRI complex|activation of phospholipase A2 activity|peptide binding|positive regulation of phosphorylation|homeostatic process|protein homodimerization activity|neuronal cell body|innate immune response|negative regulation of smooth muscle cell proliferation|positive regulation of protein secretion|defense response to Gram-positive bacterium|antimicrobial humoral immune response mediated by antimicrobial peptide",null,null,"R-HSA-1500931,R-HSA-211000,R-HSA-418990,R-HSA-421270,R-HSA-446728,R-HSA-74160,R-HSA-9708296","Cell-Cell communication|Gene Silencing by RNA|Adherens junctions interactions|Cell-cell junction organization|Cell junction organization|Gene expression (Transcription)|tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis"]
["ANGEL1",4.22706717056511,3.94060599913343,3.89881723911692,3.91633821353944,4.53679198191718,4.3505712796097,3.92072524229868,3.92663296393878,3.52495837060758,3.66122640186078,3.15604418781891,3.55560360686578,3.62921021146978,3.73741557491448,3.62733638443625,3.7450885464971,3.47872887903178,3.69132557395569,2.72191293881229,3.66977712377112,3.0133165923993,3.10523287339302,2.59960234963744,3.19642950685326,3.48416499760319,2.78425372242332,2.43798797411428,2.9176293992709,23357,"angel homolog 1","protein_coding",null,null,"GO:0000175,GO:0005634,GO:0005783,GO:0005801,GO:0005829,GO:0008190,GO:0019904,GO:0048471","3'-5'-RNA exonuclease activity|nucleus|endoplasmic reticulum|cis-Golgi network|cytosol|eukaryotic initiation factor 4E binding|protein domain specific binding|perinuclear region of cytoplasm"]
["ANGEL2",5.23121742213153,5.41890140758624,5.16798960898514,4.06511532263152,5.20574557938096,4.68887360127874,4.92792622839031,4.43449751901066,5.41980340528787,3.68729879774572,4.11955835879346,4.63636575568996,5.8465222081208,4.60108525979266,5.80692025600661,4.97439336277366,4.62538600175496,4.44666787626028,4.9798935926121,5.1132353289704,4.7845411777088,5.46345376250169,6.37421406291186,5.42244800796756,5.04075103980197,4.48941669043701,6.2382582725462,4.52756061541374,90806,"angel homolog 2","protein_coding",null,null,"GO:0000175,GO:0003730,GO:0005737,GO:0015030,GO:0045930,GO:0070935","3'-5'-RNA exonuclease activity|mRNA 3'-UTR binding|cytoplasm|Cajal body|negative regulation of mitotic cell cycle|3'-UTR-mediated mRNA stabilization"]
["ANGPT1",23.3653438077055,16.8486978062413,11.3880672375062,10.2901431399231,24.5498809239201,18.2042257599351,12.549048691549,14.1513411467769,14.1125920400639,8.28963035717575,5.73859089811035,10.5339817332055,18.0132349606782,11.011529489702,14.356365690786,16.4560092743703,27.2514608867855,15.3965653079507,13.1096720596834,21.0387355442706,30.1713145726826,19.3593760628509,28.4512104524453,32.5622078187132,31.386144630484,18.5723931069565,23.4998158339434,17.2794009123328,284,"angiopoietin 1","protein_coding","hsa04010,hsa04014,hsa04015,hsa04066,hsa04151,hsa05323","MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|HIF-1 signaling pathway|PI3K-Akt signaling pathway|Rheumatoid arthritis","GO:0001525,GO:0001701,GO:0001933,GO:0001934,GO:0001936,GO:0002040,GO:0002092,GO:0002719,GO:0005515,GO:0005576,GO:0005615,GO:0005886,GO:0005902,GO:0007162,GO:0007171,GO:0010595,GO:0010628,GO:0014842,GO:0030097,GO:0030210,GO:0030971,GO:0031398,GO:0031589,GO:0032680,GO:0033138,GO:0034394,GO:0042308,GO:0042802,GO:0043066,GO:0043116,GO:0043122,GO:0043524,GO:0043536,GO:0045121,GO:0045785,GO:0048014,GO:0050731,GO:0050918,GO:0051402,GO:0051897,GO:0062023,GO:0070062,GO:0070374,GO:0072012,GO:1905605,GO:2000352,GO:2000446","angiogenesis|in utero embryonic development|negative regulation of protein phosphorylation|positive regulation of protein phosphorylation|regulation of endothelial cell proliferation|sprouting angiogenesis|positive regulation of receptor internalization|negative regulation of cytokine production involved in immune response|protein binding|extracellular region|extracellular space|plasma membrane|microvillus|negative regulation of cell adhesion|activation of transmembrane receptor protein tyrosine kinase activity|positive regulation of endothelial cell migration|positive regulation of gene expression|regulation of skeletal muscle satellite cell proliferation|hemopoiesis|heparin biosynthetic process|receptor tyrosine kinase binding|positive regulation of protein ubiquitination|cell-substrate adhesion|regulation of tumor necrosis factor production|positive regulation of peptidyl-serine phosphorylation|protein localization to cell surface|negative regulation of protein import into nucleus|identical protein binding|negative regulation of apoptotic process|negative regulation of vascular permeability|regulation of canonical NF-kappaB signal transduction|negative regulation of neuron apoptotic process|positive regulation of blood vessel endothelial cell migration|membrane raft|positive regulation of cell adhesion|Tie signaling pathway|positive regulation of peptidyl-tyrosine phosphorylation|positive chemotaxis|neuron apoptotic process|positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction|collagen-containing extracellular matrix|extracellular exosome|positive regulation of ERK1 and ERK2 cascade|glomerulus vasculature development|positive regulation of blood-brain barrier permeability|negative regulation of endothelial cell apoptotic process|regulation of macrophage migration inhibitory factor signaling pathway","WP3614,WP1539,WP3932,WP3303,WP5087,WP4331,WP4172","Photodynamic therapy-induced HIF-1 survival signaling|Angiogenesis|Focal adhesion: PI3K-Akt-mTOR-signaling pathway|RAC1/PAK1/p38/MMP2 pathway|Pleural mesothelioma|Neovascularisation processes|PI3K-Akt signaling pathway","R-HSA-109582,R-HSA-109582,R-HSA-162582,R-HSA-202733,R-HSA-202733,R-HSA-210993,R-HSA-210993,R-HSA-5673001,R-HSA-5683057,R-HSA-5684996","Hemostasis|Hemostasis|Signal Transduction|Cell surface interactions at the vascular wall|Cell surface interactions at the vascular wall|Tie2 Signaling|Tie2 Signaling|RAF/MAP kinase cascade|MAPK family signaling cascades|MAPK1/MAPK3 signaling"]
["ANGPT2",0.782451324415138,0.564261171498466,0.249665699895236,0.299185607369559,0.414771341698338,0.336165469017866,0.200397652448473,0.275815771979146,0.725311340961784,0.4679221367335,0.423234122065982,0.746049681554881,0.646835739483268,0.482687469668571,0.294874980348769,0.509135194166273,0.629358056491773,0.53943209429491,0.519917661128162,0.585216945745729,0.781960262391548,0.641665650863153,0.545260032116988,0.764433521423679,0.588143057261457,0.524801996457632,0.603751507528579,0.620207361451856,285,"angiopoietin 2","protein_coding","hsa04010,hsa04014,hsa04015,hsa04066,hsa04151,hsa05167","MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|HIF-1 signaling pathway|PI3K-Akt signaling pathway|Kaposi sarcoma-associated herpesvirus infection","GO:0001525,GO:0001666,GO:0005102,GO:0005515,GO:0005576,GO:0005615,GO:0007165,GO:0007281,GO:0009612,GO:0009749,GO:0010467,GO:0010812,GO:0014070,GO:0014823,GO:0016525,GO:0030971,GO:0031100,GO:0042995,GO:0043537,GO:0045766,GO:0046872,GO:0048014,GO:0050928,GO:0060135,GO:0062023,GO:0071363,GO:0072012","angiogenesis|response to hypoxia|signaling receptor binding|protein binding|extracellular region|extracellular space|signal transduction|germ cell development|response to mechanical stimulus|response to glucose|gene expression|negative regulation of cell-substrate adhesion|response to organic cyclic compound|response to activity|negative regulation of angiogenesis|receptor tyrosine kinase binding|animal organ regeneration|cell projection|negative regulation of blood vessel endothelial cell migration|positive regulation of angiogenesis|metal ion binding|Tie signaling pathway|negative regulation of positive chemotaxis|maternal process involved in female pregnancy|collagen-containing extracellular matrix|cellular response to growth factor stimulus|glomerulus vasculature development","WP3614,WP3668,WP3932,WP3303,WP5087,WP4172","Photodynamic therapy-induced HIF-1 survival signaling|Hypothesized pathways in pathogenesis of cardiovascular disease|Focal adhesion: PI3K-Akt-mTOR-signaling pathway|RAC1/PAK1/p38/MMP2 pathway|Pleural mesothelioma|PI3K-Akt signaling pathway","R-HSA-109582,R-HSA-202733,R-HSA-210993","Hemostasis|Cell surface interactions at the vascular wall|Tie2 Signaling"]
["ANGPT4",0.0057038119414395,0.00542527148964717,0,0.0328217257122083,0.00557352493025494,0.0160685102520389,0,0.011186280414743,0.034423569733836,0.0659220237269024,0.0214564215116549,0.0401695610494118,0.0542427458216474,0.0108757727619959,0.0159135395965185,0,0.0712903057966994,0.0949956534633207,0.0158147539249406,0.0658188783171742,0.102287501134061,0.0542168347519793,0.0112618361361445,0.0111449362072258,0.130062506860395,0.0325178836146163,0.0165584221719914,0.010724486355253,51378,"angiopoietin 4","protein_coding","hsa04010,hsa04014,hsa04015,hsa04066,hsa04151","MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|HIF-1 signaling pathway|PI3K-Akt signaling pathway","GO:0001525,GO:0001935,GO:0005576,GO:0005615,GO:0007165,GO:0007219,GO:0010595,GO:0016525,GO:0030297,GO:0030971,GO:0043066,GO:0043536,GO:0043537,GO:0045766,GO:0050731,GO:0062023,GO:0071456","angiogenesis|endothelial cell proliferation|extracellular region|extracellular space|signal transduction|Notch signaling pathway|positive regulation of endothelial cell migration|negative regulation of angiogenesis|transmembrane receptor protein tyrosine kinase activator activity|receptor tyrosine kinase binding|negative regulation of apoptotic process|positive regulation of blood vessel endothelial cell migration|negative regulation of blood vessel endothelial cell migration|positive regulation of angiogenesis|positive regulation of peptidyl-tyrosine phosphorylation|collagen-containing extracellular matrix|cellular response to hypoxia","WP3932,WP3303,WP5087,WP4172","Focal adhesion: PI3K-Akt-mTOR-signaling pathway|RAC1/PAK1/p38/MMP2 pathway|Pleural mesothelioma|PI3K-Akt signaling pathway","R-HSA-109582,R-HSA-202733,R-HSA-210993","Hemostasis|Cell surface interactions at the vascular wall|Tie2 Signaling"]
["ANGPTL1",0.0912996282311367,0.0723675784930074,0.114287145109341,0.0948584619581643,0.170993794205151,0.185759174497087,0.0922802060315227,0.104449485938619,0.061223366473651,0.014655540696836,0.0214655055173754,0.0688912588071321,0.173650273837836,0.0652822634291186,0.0636811076487269,0.0649244371223037,0.168243202403214,0.204151131962272,0.239079680089863,0.175591317486291,0.308787697096747,0.13740746428787,0.353020260546529,0.319623432988994,0.31680799999673,0.144585114274792,0.272409334635314,0.143053690417516,9068,"angiopoietin like 1","protein_coding",null,null,"GO:0005102,GO:0005615,GO:0007169,GO:0062023,GO:0070062","signaling receptor binding|extracellular space|transmembrane receptor protein tyrosine kinase signaling pathway|collagen-containing extracellular matrix|extracellular exosome","WP3303","RAC1/PAK1/p38/MMP2 pathway"]
["ANGPTL2",18.8381148161715,23.3977642749843,24.2100271459515,22.6901087103232,21.8628176853463,24.6298532086769,27.25299148521,25.0216847728084,17.837587078914,21.3721350810621,20.3417833546301,18.1136058637752,19.2408875266964,21.898719895358,21.7449466505306,21.3542892975206,10.0930192306438,11.8108526299325,13.1278805723859,11.7856730780475,10.4980267883606,10.8601080415996,11.9976856662721,10.6996753028731,10.3183917395388,10.8682683829774,11.2117971273453,10.9590132304403,23452,"angiopoietin like 2","protein_coding",null,null,"GO:0005102,GO:0005515,GO:0005615,GO:0007267,GO:0062023,GO:0070062","signaling receptor binding|protein binding|extracellular space|cell-cell signaling|collagen-containing extracellular matrix|extracellular exosome","WP5322","CKAP4 signaling pathway map"]
["ANGPTL4",2.45432547921906,1.14100535868353,0.737864553771633,1.52073995799898,1.10481803747905,0.841617334070562,0.29588123979157,0.865331744083079,1.02632127038329,1.31471444711,0.85583135194749,0.568761064399001,0.485165985670839,0.630983964069884,0.230815513452112,0.196101688597035,0.980992756421205,0.956840277637795,0.611687177896834,0.914882408608721,0.88496243544087,0.825698820735797,0.598933824423133,0.781308484370908,0.929565833530778,0.982605613572102,0.627108243765912,0.674057281528428,51129,"angiopoietin like 4","protein_coding","hsa03320,hsa04979","PPAR signaling pathway|Cholesterol metabolism","GO:0001525,GO:0001666,GO:0004857,GO:0005515,GO:0005576,GO:0005615,GO:0006629,GO:0042802,GO:0043066,GO:0043335,GO:0045766,GO:0051005,GO:0062023,GO:0070328,GO:0072562,GO:0072577,GO:2000352","angiogenesis|response to hypoxia|enzyme inhibitor activity|protein binding|extracellular region|extracellular space|lipid metabolic process|identical protein binding|negative regulation of apoptotic process|protein unfolding|positive regulation of angiogenesis|negative regulation of lipoprotein lipase activity|collagen-containing extracellular matrix|triglyceride homeostasis|blood microparticle|endothelial cell apoptotic process|negative regulation of endothelial cell apoptotic process","WP2882,WP2880,WP3942,WP5108","Nuclear receptors meta-pathway|Glucocorticoid receptor pathway|PPAR signaling pathway|Familial  hyperlipidemia type 1","R-HSA-1266738,R-HSA-1430728,R-HSA-1500931,R-HSA-174824,R-HSA-1989781,R-HSA-381340,R-HSA-382551,R-HSA-400206,R-HSA-418990,R-HSA-421270,R-HSA-446728,R-HSA-556833,R-HSA-8963889,R-HSA-8963899,R-HSA-9759475,R-HSA-9759476,R-HSA-9762292,R-HSA-9764260","Developmental Biology|Metabolism|Cell-Cell communication|Plasma lipoprotein assembly, remodeling, and clearance|PPARA activates gene expression|Transcriptional regulation of white adipocyte differentiation|Transport of small molecules|Regulation of lipid metabolism by PPARalpha|Adherens junctions interactions|Cell-cell junction organization|Cell junction organization|Metabolism of lipids|Assembly of active LPL and LIPC lipase complexes|Plasma lipoprotein remodeling|Regulation of CDH11 Expression and Function|Regulation of Homotypic Cell-Cell Adhesion|Regulation of CDH11 function|Regulation of Expression and Function of Type II Classical Cadherins"]
["ANGPTL5",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.00865646732655922,0,0.00894916025274122,0.00861244356713577,0,0.00895085229416912,0,0,0,0,0,0,0,0.00875067722978696,253935,"angiopoietin like 5","protein_coding",null,null,"GO:0005102,GO:0005515,GO:0005615,GO:0062023","signaling receptor binding|protein binding|extracellular space|collagen-containing extracellular matrix"]
["ANGPTL6",0.366004280179811,0.1740653975565,0.249122990889119,0.579182020663565,0.384467274024626,0.223402836131425,0.324404753742963,0.376847788880376,0.662671244652176,0.387759937255798,0.249549252703526,0.653609520506544,0.226243436374091,0.375110792455411,0.212738708229086,0.260270740805976,0.2903100295431,0.110061532727606,0.152221032686903,0.105587243356064,0.0431817210097166,0.217437848810127,0.298094609660698,0.26818212075025,0.299363742213959,0.31299290827429,0.274486105309999,0.292473415734468,83854,"angiopoietin like 6","protein_coding",null,null,"GO:0001525,GO:0005102,GO:0005615,GO:0030141,GO:0030154,GO:0062023,GO:0070062","angiogenesis|signaling receptor binding|extracellular space|secretory granule|cell differentiation|collagen-containing extracellular matrix|extracellular exosome"]
["ANGPTL8",0,0,0.203156213149138,0,0,0,0,0,0,0,0,0.0311011378636173,0,0,0,0,0.0594421286512353,0.0572055884642779,0,0.0297266837659561,0,0,0.0305180261349881,0.0302012434147644,0,0.0293729965524993,0,0.145309410879948,55908,"angiopoietin like 8","protein_coding","hsa04979","Cholesterol metabolism","GO:0005179,GO:0005515,GO:0005576,GO:0007165,GO:0010954,GO:0019216,GO:0044255,GO:0044342,GO:0045444,GO:0048469,GO:0050746,GO:0070328","hormone activity|protein binding|extracellular region|signal transduction|positive regulation of protein processing|regulation of lipid metabolic process|cellular lipid metabolic process|type B pancreatic cell proliferation|fat cell differentiation|cell maturation|regulation of lipoprotein metabolic process|triglyceride homeostasis","WP5304,WP3915,WP5108","Cholesterol metabolism|Angiopoietin-like protein 8 regulatory pathway|Familial  hyperlipidemia type 1","R-HSA-174824,R-HSA-382551,R-HSA-8963889,R-HSA-8963899","Plasma lipoprotein assembly, remodeling, and clearance|Transport of small molecules|Assembly of active LPL and LIPC lipase complexes|Plasma lipoprotein remodeling"]
["ANHX",0,0,0,0,0,0,0,0,0,0,0,0.0087966890097549,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,647589,"anomalous homeobox","protein_coding",null,null,"GO:0000978,GO:0000981,GO:0005634,GO:0005667,GO:0006357,GO:0014857,GO:0048741","RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|transcription regulator complex|regulation of transcription by RNA polymerase II|regulation of skeletal muscle cell proliferation|skeletal muscle fiber development"]
["ANK1",0.372043121189051,0.225193013074664,0.256673315603255,0.28653005063929,0.371807260639058,0.304373157565894,0.136741434533536,0.21557801007559,0.487626445989871,0.616210780864599,0.458561462648632,0.467882864472738,0.324325566992114,0.241839250658058,0.264740910408748,0.216462309339073,0.298080770609916,0.380748529828741,0.304776302271173,0.414681643801631,0.566634118991115,0.476879124474467,0.339463581382745,0.335939887017597,0.438710558458756,0.382966873495447,0.21819351229564,0.357712753006849,286,"ankyrin 1","protein_coding","hsa05205","Proteoglycans in cancer","GO:0005198,GO:0005200,GO:0005515,GO:0005829,GO:0005856,GO:0005886,GO:0006887,GO:0006888,GO:0007010,GO:0007165,GO:0008093,GO:0009898,GO:0010638,GO:0014731,GO:0016323,GO:0016529,GO:0019899,GO:0019903,GO:0030018,GO:0030507,GO:0030673,GO:0031430,GO:0042383,GO:0043005,GO:0044325,GO:0045199,GO:0045211,GO:0051117,GO:0072659,GO:0170014","structural molecule activity|structural constituent of cytoskeleton|protein binding|cytosol|cytoskeleton|plasma membrane|exocytosis|endoplasmic reticulum to Golgi vesicle-mediated transport|cytoskeleton organization|signal transduction|cytoskeletal anchor activity|cytoplasmic side of plasma membrane|positive regulation of organelle organization|spectrin-associated cytoskeleton|basolateral plasma membrane|sarcoplasmic reticulum|enzyme binding|protein phosphatase binding|Z disc|spectrin binding|axolemma|M band|sarcolemma|neuron projection|transmembrane transporter binding|maintenance of epithelial cell apical/basal polarity|postsynaptic membrane|ATPase binding|protein localization to plasma membrane|ankyrin-1 complex",null,null,"R-HSA-1266738,R-HSA-1266738,R-HSA-199977,R-HSA-199991,R-HSA-373760,R-HSA-373760,R-HSA-392499,R-HSA-422475,R-HSA-422475,R-HSA-445095,R-HSA-445095,R-HSA-446203,R-HSA-447038,R-HSA-447041,R-HSA-447043,R-HSA-447043,R-HSA-5653656,R-HSA-597592,R-HSA-6807878,R-HSA-948021,R-HSA-9675108,R-HSA-9675108","Developmental Biology|Developmental Biology|ER to Golgi Anterograde Transport|Membrane Trafficking|L1CAM interactions|L1CAM interactions|Metabolism of proteins|Axon guidance|Axon guidance|Interaction between L1 and Ankyrins|Interaction between L1 and Ankyrins|Asparagine N-linked glycosylation|NrCAM interactions|CHL1 interactions|Neurofascin interactions|Neurofascin interactions|Vesicle-mediated transport|Post-translational protein modification|COPI-mediated anterograde transport|Transport to the Golgi and subsequent modification|Nervous system development|Nervous system development"]
["ANK2",1.37821959781427,1.4200338953576,0.851303226496909,0.865118667880494,1.95330782134492,1.48753954967537,0.772692831368471,1.06022434947741,2.24147817696681,1.87380140187856,1.33308385346297,1.72653471119018,2.63181071942062,2.05709475154473,1.7844929149531,2.4242884998314,1.06972959885107,0.719763895666092,0.35439259604776,0.955080413347723,1.18068940331512,0.743904407373937,0.5585156394972,0.872066405780864,1.11088075730712,0.830231951526927,0.489674172166495,0.613123880478468,287,"ankyrin 2","protein_coding","hsa05205","Proteoglycans in cancer","GO:0002027,GO:0003283,GO:0005200,GO:0005515,GO:0005739,GO:0005764,GO:0005769,GO:0005829,GO:0005856,GO:0005886,GO:0006874,GO:0006897,GO:0007010,GO:0008093,GO:0008104,GO:0010628,GO:0010881,GO:0010882,GO:0014704,GO:0015031,GO:0016323,GO:0016324,GO:0019899,GO:0019901,GO:0030018,GO:0030315,GO:0030507,GO:0030674,GO:0030913,GO:0031430,GO:0031647,GO:0031672,GO:0033292,GO:0033365,GO:0034394,GO:0036309,GO:0036371,GO:0042383,GO:0043005,GO:0043034,GO:0043268,GO:0044325,GO:0045211,GO:0050821,GO:0051117,GO:0051279,GO:0051597,GO:0051924,GO:0051928,GO:0055037,GO:0055117,GO:0060307,GO:0070296,GO:0070972,GO:0072659,GO:0086004,GO:0086005,GO:0086014,GO:0086015,GO:0086046,GO:0086066,GO:0086070,GO:0086091,GO:0098907,GO:0098910,GO:0140031,GO:1901018,GO:1901019,GO:1901021,GO:2001259","regulation of heart rate|atrial septum development|structural constituent of cytoskeleton|protein binding|mitochondrion|lysosome|early endosome|cytosol|cytoskeleton|plasma membrane|intracellular calcium ion homeostasis|endocytosis|cytoskeleton organization|cytoskeletal anchor activity|protein localization|positive regulation of gene expression|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|regulation of cardiac muscle contraction by calcium ion signaling|intercalated disc|protein transport|basolateral plasma membrane|apical plasma membrane|enzyme binding|protein kinase binding|Z disc|T-tubule|spectrin binding|protein-macromolecule adaptor activity|paranodal junction assembly|M band|regulation of protein stability|A band|T-tubule organization|protein localization to organelle|protein localization to cell surface|protein localization to M-band|protein localization to T-tubule|sarcolemma|neuron projection|costamere|positive regulation of potassium ion transport|transmembrane transporter binding|postsynaptic membrane|protein stabilization|ATPase binding|regulation of release of sequestered calcium ion into cytosol|response to methylmercury|regulation of calcium ion transport|positive regulation of calcium ion transport|recycling endosome|regulation of cardiac muscle contraction|regulation of ventricular cardiac muscle cell membrane repolarization|sarcoplasmic reticulum calcium ion transport|protein localization to endoplasmic reticulum|protein localization to plasma membrane|regulation of cardiac muscle cell contraction|ventricular cardiac muscle cell action potential|atrial cardiac muscle cell action potential|SA node cell action potential|membrane depolarization during SA node cell action potential|atrial cardiac muscle cell to AV node cell communication|SA node cell to atrial cardiac muscle cell communication|regulation of heart rate by cardiac conduction|regulation of SA node cell action potential|regulation of atrial cardiac muscle cell action potential|phosphorylation-dependent protein binding|positive regulation of potassium ion transmembrane transporter activity|regulation of calcium ion transmembrane transporter activity|positive regulation of calcium ion transmembrane transporter activity|positive regulation of cation channel activity","WP5323","Fatty Acids and Lipoproteins Transport in Hepatocytes","R-HSA-1266738,R-HSA-1266738,R-HSA-199977,R-HSA-199991,R-HSA-373760,R-HSA-373760,R-HSA-392499,R-HSA-422475,R-HSA-422475,R-HSA-445095,R-HSA-445095,R-HSA-446203,R-HSA-5653656,R-HSA-597592,R-HSA-6807878,R-HSA-948021,R-HSA-9675108,R-HSA-9675108","Developmental Biology|Developmental Biology|ER to Golgi Anterograde Transport|Membrane Trafficking|L1CAM interactions|L1CAM interactions|Metabolism of proteins|Axon guidance|Axon guidance|Interaction between L1 and Ankyrins|Interaction between L1 and Ankyrins|Asparagine N-linked glycosylation|Vesicle-mediated transport|Post-translational protein modification|COPI-mediated anterograde transport|Transport to the Golgi and subsequent modification|Nervous system development|Nervous system development"]
["ANK2-AS1",0,0,0,0,0,0,0,0,0,0.0114119957558,0,0,0,0,0,0,0,0,0,0,0.0223671824342198,0,0,0,0,0,0,0,105377373,null,"non_coding"]
["ANK3",0.0958159309309589,0.114611489874301,0.169007162979243,0.0710082692581388,0.11206903418841,0.110425142459105,0.111067009982079,0.112463446196843,0.0890764866462791,0.057327332190987,0.0546117234296,0.103701725948528,0.0869782779806423,0.0539788124960823,0.0904584052298007,0.0770832000129376,0.0879338857061682,0.0792522919891796,0.0845298937976442,0.0879505115988026,0.115100402929217,0.0786570410338093,0.0831257911354567,0.0907728884366207,0.0978727490603549,0.0620743421327055,0.0899096403100174,0.0518631262270355,288,"ankyrin 3","protein_coding","hsa05205","Proteoglycans in cancer","GO:0000281,GO:0005200,GO:0005515,GO:0005764,GO:0005783,GO:0005794,GO:0005829,GO:0005886,GO:0005923,GO:0007009,GO:0007010,GO:0007165,GO:0007409,GO:0007528,GO:0008092,GO:0008093,GO:0009925,GO:0009986,GO:0010628,GO:0010650,GO:0010765,GO:0010960,GO:0014704,GO:0014731,GO:0016323,GO:0016328,GO:0016529,GO:0019228,GO:0030018,GO:0030315,GO:0030425,GO:0030507,GO:0030674,GO:0031594,GO:0033268,GO:0034112,GO:0042383,GO:0043001,GO:0043005,GO:0043034,GO:0043194,GO:0043266,GO:0044325,GO:0045184,GO:0045211,GO:0045296,GO:0045838,GO:0071286,GO:0071709,GO:0072659,GO:0072660,GO:0090314,GO:0099612,GO:1900827,GO:1902260,GO:2000651,GO:2001259","mitotic cytokinesis|structural constituent of cytoskeleton|protein binding|lysosome|endoplasmic reticulum|Golgi apparatus|cytosol|plasma membrane|bicellular tight junction|plasma membrane organization|cytoskeleton organization|signal transduction|axonogenesis|neuromuscular junction development|cytoskeletal protein binding|cytoskeletal anchor activity|basal plasma membrane|cell surface|positive regulation of gene expression|positive regulation of cell communication by electrical coupling|positive regulation of sodium ion transport|magnesium ion homeostasis|intercalated disc|spectrin-associated cytoskeleton|basolateral plasma membrane|lateral plasma membrane|sarcoplasmic reticulum|neuronal action potential|Z disc|T-tubule|dendrite|spectrin binding|protein-macromolecule adaptor activity|neuromuscular junction|node of Ranvier|positive regulation of homotypic cell-cell adhesion|sarcolemma|Golgi to plasma membrane protein transport|neuron projection|costamere|axon initial segment|regulation of potassium ion transport|transmembrane transporter binding|establishment of protein localization|postsynaptic membrane|cadherin binding|positive regulation of membrane potential|cellular response to magnesium ion|membrane assembly|protein localization to plasma membrane|maintenance of protein location in plasma membrane|positive regulation of protein targeting to membrane|protein localization to axon|positive regulation of membrane depolarization during cardiac muscle cell action potential|negative regulation of delayed rectifier potassium channel activity|positive regulation of sodium ion transmembrane transporter activity|positive regulation of cation channel activity","WP4148","Splicing factor NOVA regulated synaptic proteins","R-HSA-1266738,R-HSA-1266738,R-HSA-199977,R-HSA-199991,R-HSA-373760,R-HSA-373760,R-HSA-392499,R-HSA-422475,R-HSA-422475,R-HSA-445095,R-HSA-445095,R-HSA-446203,R-HSA-5653656,R-HSA-597592,R-HSA-6807878,R-HSA-948021,R-HSA-9675108,R-HSA-9675108","Developmental Biology|Developmental Biology|ER to Golgi Anterograde Transport|Membrane Trafficking|L1CAM interactions|L1CAM interactions|Metabolism of proteins|Axon guidance|Axon guidance|Interaction between L1 and Ankyrins|Interaction between L1 and Ankyrins|Asparagine N-linked glycosylation|Vesicle-mediated transport|Post-translational protein modification|COPI-mediated anterograde transport|Transport to the Golgi and subsequent modification|Nervous system development|Nervous system development"]
["ANK3-DT",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.0161274225836581,0,0,0,0,0,0,0,0,0,0,0,105378320,null,"non_coding"]
["ANKAR",0.159122521331205,0.126808363889956,0.141314787704251,0.185604031249078,0.289963790460522,0.274617368787346,0.236733314861953,0.198206683015599,0.263875590945773,0.144971308560238,0.238623956436694,0.212011713247709,0.241300602878641,0.200905089469244,0.127985344621393,0.228347297038964,0.194334412942104,0.139272061257958,0.246432284463662,0.148880034585337,0.215134255105779,0.179867030722169,0.280212737734658,0.331924578231699,0.294196908466286,0.130763257147565,0.320444742886195,0.19002427873337,150709,"ankyrin and armadillo repeat containing","protein_coding",null,null,"GO:0016020","membrane"]
["ANKDD1A",2.15580179888432,1.96784271792881,2.35038645346764,2.46770830978745,2.7181403490884,2.36725099869176,2.21410002236807,2.22478559878422,1.70502682788408,1.44839607532699,1.52873024733821,1.76661684226024,1.90961402998927,1.54146981386872,1.88362049177933,1.73082980228985,1.29542052700757,1.15820563242219,1.01228704807136,1.7386994500916,0.951741284164883,1.19810288134437,1.32157519948896,1.03609451126614,1.27549262227457,1.21417226381347,1.09353578566355,1.39744449372014,348094,"ankyrin repeat and death domain containing 1A","protein_coding",null,null,"GO:0007165","signal transduction"]
["ANKDD1B",0.0663479277941989,0.126215774557319,0.0533912651796411,0.0909021775175203,0.20375897821676,0.0623040853443451,0.0176862907048406,0.111532407679484,0.123940182683275,0.0365151762931717,0.0267413101434814,0.0286077976973358,0.0630962910433101,0.0271091255660299,0.158665375808326,0.0179736896956026,0.0637895135877532,0.00876991440591603,0.0438001213368901,0.0364580425371501,0.0715686920363573,0.0991039511749789,0.0561428666449571,0.0277800466853107,0.0469849115928443,0.00900606645350895,0,0.0712854043810493,728780,"ankyrin repeat and death domain containing 1B","protein_coding",null,null,"GO:0007165","signal transduction"]
["ANKEF1",1.45243534144232,1.27847934710498,1.02616548900881,0.887723270459317,1.39039239800752,0.883074452064962,1.27242443669269,0.89800394435197,0.658666975487382,0.441003288042628,0.40283402655594,0.698437826960271,0.650827746642588,0.647766985032017,0.746350335811439,0.760922308636519,1.14081116167254,0.92022111182208,0.864578395090483,0.923237499098298,0.855059595156566,0.88919570040534,0.811718180434979,1.17848285719274,1.03483173614065,0.987104361952048,1.15774673204956,0.89333306350509,63926,"ankyrin repeat and EF-hand domain containing 1","protein_coding",null,null,"GO:0005509,GO:0005515","calcium ion binding|protein binding"]
["ANKFN1",0.010854366118616,0.00114714478368182,0.00226454831507761,0.00231332640919715,0.020034367140018,3.39760097763572E-3,2.25045012592577E-3,0.0106437575759626,0.021836041863287,0.0104541458145052,0.0136105384185156,0.0169872798102564,0.0252325478438026,0.0103483092179037,0.00897288868604197,0.00686105858721674,0.0255097712864144,0.0145067905425049,3.343945552739E-3,0.0150768058328879,0.0409796483683638,0.0286596529280406,0.0119062765825733,0.0176740308650672,0.0286967216292889,0.0114595557217929,0.0070023804916855,0.0192749023031126,162282,"ankyrin repeat and fibronectin type III domain containing 1","protein_coding",null,null,"GO:0000132,GO:0005819,GO:0061172","establishment of mitotic spindle orientation|spindle|regulation of establishment of bipolar cell polarity"]
["ANKFY1",10.3745865989618,9.92772597239642,9.06155624773884,8.35544842876417,10.3832342070394,9.89247665627459,8.76262465793663,8.90442738064006,10.3722175820213,10.8944229907812,8.5693473382542,10.1187026381603,10.4039966108338,9.57227618879264,10.2539831935977,11.0554361663509,8.61237519723635,8.74027679754118,6.79003339941086,9.12216384847278,8.98055884635363,9.03873630915564,7.51794450496619,8.51152135063129,9.84948729567938,7.6619914381095,7.26964506291217,7.32841075252905,51479,"ankyrin repeat and FYVE domain containing 1","protein_coding",null,null,"GO:0005515,GO:0005765,GO:0005768,GO:0005769,GO:0005829,GO:0006897,GO:0010008,GO:0016020,GO:0016197,GO:0031267,GO:0034058,GO:0042147,GO:0043231,GO:0044354,GO:0046872,GO:0048549,GO:0070062,GO:0090160,GO:1901981","protein binding|lysosomal membrane|endosome|early endosome|cytosol|endocytosis|endosome membrane|membrane|endosomal transport|small GTPase binding|endosomal vesicle fusion|retrograde transport, endosome to Golgi|intracellular membrane-bounded organelle|macropinosome|metal ion binding|positive regulation of pinocytosis|extracellular exosome|Golgi to lysosome transport|phosphatidylinositol phosphate binding","WP5323","Fatty Acids and Lipoproteins Transport in Hepatocytes","R-HSA-162582,R-HSA-194315,R-HSA-9012999,R-HSA-9013405,R-HSA-9716542","Signal Transduction|Signaling by Rho GTPases|RHO GTPase cycle|RHOD GTPase cycle|Signaling by Rho GTPases, Miro GTPases and RHOBTB3"]
["ANKH",3.62525710860608,3.19121072573456,2.65456528305927,2.97397212788632,2.95465991541309,2.9783859402872,2.0738167803291,2.63700942701093,1.95106467201574,2.0447627240255,1.68803403400231,1.94177987234422,1.53260094980078,1.77565419453332,2.06715613365172,1.83607031286186,2.97207805923066,3.47039955144579,2.96108054658203,3.35001989357501,2.91467341505584,3.04539195696543,2.85170924500707,3.12694592319644,3.39643721544397,3.12371653456355,2.6769844367126,2.97571478249924,56172,"ANKH inorganic pyrophosphate transport regulator","protein_coding",null,null,"GO:0001501,GO:0005315,GO:0005347,GO:0005576,GO:0005886,GO:0007626,GO:0010467,GO:0015114,GO:0016020,GO:0019867,GO:0030282,GO:0030500,GO:0030504,GO:0030505,GO:0035435,GO:0046716,GO:0055062,GO:0055074,GO:0055085,GO:0071344,GO:0071529,GO:0140928,GO:1904383,GO:1904669","skeletal system development|inorganic phosphate transmembrane transporter activity|ATP transmembrane transporter activity|extracellular region|plasma membrane|locomotory behavior|gene expression|phosphate ion transmembrane transporter activity|membrane|outer membrane|bone mineralization|regulation of bone mineralization|inorganic diphosphate transmembrane transporter activity|inorganic diphosphate transport|phosphate ion transmembrane transport|muscle cell cellular homeostasis|phosphate ion homeostasis|calcium ion homeostasis|transmembrane transport|diphosphate metabolic process|cementum mineralization|inhibition of non-skeletal tissue mineralization|response to sodium phosphate|ATP export",null,null,"R-HSA-382551,R-HSA-5223345","Transport of small molecules|Miscellaneous transport and binding events"]
["ANKHD1",0.118257050474744,0.176323253199455,0.327070560442416,0.113415394069405,0.187387802848362,0.177078767987393,0.161026190496005,0.209986139618512,0.125380322344523,0.0523309148512646,0.192370022412295,0.170425680282776,0.136777386221125,0.127979243957439,0.14267467513995,0.127277761842562,0.159790365281101,0.168564534564173,0.129973250737801,0.138306268790149,0.13575055144079,0.19747296024971,0.189317420842136,0.103043749170412,0.0950617182144055,0.200435700449305,0.13608507391244,0.162255858181527,54882,"ANKHD1-EIF4EBP3 readthrough","protein_coding",null,null,"GO:0003723,GO:0005515,GO:0005737,GO:0045087","RNA binding|protein binding|cytoplasm|innate immune response"]
["ANKHD1-EIF4EBP3",0,0.00615750073488773,0.0121553600841257,0.00620859252785369,3.16288170273593E-3,0.00303953648139353,0,0,0,3.11747002214758E-3,0.00608807925456781,3.25650723067655E-3,0,0.00617181821243908,0,0.00306899456617998,0,2.99491313285605E-3,0,0.00311259224830857,0,0.0123068569182446,0,3.16228197138263E-3,0,0,0,0.00608596571985183,404734,"ankyrin repeat and KH domain containing 1","protein_coding"]
["ANKIB1",12.0027437869229,10.2882863256821,8.35066335682232,6.49984406653888,12.6093617066037,9.98556195621932,8.36214519650687,7.5797353891528,12.2613081372651,8.46436185204542,6.72155062285965,9.27390800104372,12.8296910214133,9.01912910984651,10.8698795992649,12.7752620507426,10.3667072367754,8.20241518128336,8.20888333364478,10.9574244311812,11.196380024101,9.54189439763998,12.8651290363501,11.8177370209912,11.157905660723,7.79709436561425,10.0637214716139,7.20687005476433,54467,"ankyrin repeat and IBR domain containing 1","protein_coding",null,null,"GO:0000151,GO:0000209,GO:0005515,GO:0005737,GO:0006511,GO:0008270,GO:0016567,GO:0031624,GO:0032436,GO:0061630","ubiquitin ligase complex|protein polyubiquitination|protein binding|cytoplasm|ubiquitin-dependent protein catabolic process|zinc ion binding|protein ubiquitination|ubiquitin conjugating enzyme binding|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|ubiquitin protein ligase activity"]
["ANKK1",0.032355547169084,0.0192346834659208,0.0151882728853112,0.0581828491057377,0.0632329574082757,0.0227876307430266,0.0264140041524357,0.0237958115109117,0,0.023371904286072,0.0228213911622088,0.00813809218816935,0.0230773788524926,0.0192794081294796,0.00376130973409085,0.0191737334937336,0,0,0.0448555301120896,0.0116676676266678,0.0267214838908439,0.00768878502739248,0.00798551201491662,0.00790262093253551,0.0400975509587544,0.0345865381761463,0.00391373359263973,0.0114067342494207,255239,"ankyrin repeat and kinase domain containing 1","protein_coding",null,null,"GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0010564,GO:0016310,GO:0042995,GO:0106310","protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|cytoplasm|regulation of cell cycle process|phosphorylation|cell projection|protein serine kinase activity"]
["ANKLE1",0.236617689438325,0.164468881884327,0.145248755846572,0.192017806985692,0.142284828199242,0.128190039586657,0.0679268207489087,0.133861481870549,0.292929625139967,0.227893163050496,0.094145301207368,0.146496649383251,0.199057325635429,0.216909613745749,0.0507814909744406,0.0690306191685264,0.21874382251805,0.0926259291946918,0.0841104288197945,0.210033773752171,0.163204162849282,0.302768623778693,0.161718750241314,0.133366733242781,0.162407264973726,0.155651098544237,0.0968721736476643,0.077001232720178,126549,"ankyrin repeat and LEM domain containing 1","protein_coding",null,null,"GO:0000712,GO:0000724,GO:0004519,GO:0004520,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006611,GO:0006974,GO:0045950,GO:0090305,GO:1905453,GO:1905456","resolution of meiotic recombination intermediates|double-strand break repair via homologous recombination|endonuclease activity|DNA endonuclease activity|nucleus|nucleoplasm|cytoplasm|cytosol|protein export from nucleus|DNA damage response|negative regulation of mitotic recombination|nucleic acid phosphodiester bond hydrolysis|regulation of myeloid progenitor cell differentiation|regulation of lymphoid progenitor cell differentiation"]
["ANKLE2",20.3787095882884,20.2380284336959,17.8893307960063,19.1160954611223,18.8146277288463,19.0034451013952,14.9203492464764,16.5574434832979,19.1295576507125,18.9189248875229,17.1936565612455,18.3884522945238,16.2573934771897,16.4484500495385,15.2632937392288,15.8352654977938,20.0373843345781,20.9264754308478,16.7660001235059,20.4857463903859,20.2609139928527,20.3944311065795,16.5862944239897,19.1344153795772,19.8601622575559,19.8127072953246,14.9057339399678,18.5459100607627,23141,"ankyrin repeat and LEM domain containing 2","protein_coding",null,null,"GO:0005515,GO:0005783,GO:0005789,GO:0007084,GO:0007417,GO:0016020,GO:0019888,GO:0035307,GO:0042326,GO:0043066,GO:0050790,GO:0051301,GO:0051721","protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|mitotic nuclear membrane reassembly|central nervous system development|membrane|protein phosphatase regulator activity|positive regulation of protein dephosphorylation|negative regulation of phosphorylation|negative regulation of apoptotic process|regulation of catalytic activity|cell division|protein phosphatase 2A binding",null,null,"R-HSA-162582,R-HSA-1640170,R-HSA-194315,R-HSA-2555396,R-HSA-2995383,R-HSA-2995410,R-HSA-68882,R-HSA-68886,R-HSA-69278,R-HSA-9012999,R-HSA-9013404,R-HSA-9013408,R-HSA-9716542","Signal Transduction|Cell Cycle|Signaling by Rho GTPases|Mitotic Metaphase and Anaphase|Initiation of Nuclear Envelope (NE) Reformation|Nuclear Envelope (NE) Reassembly|Mitotic Anaphase|M Phase|Cell Cycle, Mitotic|RHO GTPase cycle|RAC2 GTPase cycle|RHOG GTPase cycle|Signaling by Rho GTPases, Miro GTPases and RHOBTB3"]
["ANKMY1",0.924926446341359,0.87166257008772,0.956254923751058,0.906105557544707,0.853896166369701,0.823260423478267,0.77824146746567,0.776219070938907,0.833320191631335,0.959137344584804,0.88318095224742,0.882027091366801,0.779765305143117,0.865574606011033,0.80740486154941,0.723635389430851,0.76651003408428,0.879428297136348,0.791903980945141,0.894885505105117,0.814079748000547,0.862995511336843,0.761855332154618,0.837103067657902,0.652584371082021,0.792579347455127,0.75226812169399,0.837530347841637,51281,"ankyrin repeat and MYND domain containing 1","protein_coding",null,null,"GO:0046872","metal ion binding","WP5224","2q37 copy number variation syndrome"]
["ANKMY2",11.1084963119478,10.8818552405011,10.8069182124865,9.58253498730157,11.3856940925739,10.7338048347008,11.3967842979067,11.2185615397473,9.4125784013165,6.79341751827398,8.56380725065264,8.80722927542168,10.3057208078796,9.29554611961995,11.1262392049659,10.5420822529292,12.1215791038443,9.39384520326951,11.9871269586298,11.8432705974432,11.6434167387839,10.2147188050925,12.615484457981,13.1038449105935,11.6416930467523,10.0483497187242,12.7844905414562,10.3486769748654,57037,"ankyrin repeat and MYND domain containing 2","protein_coding",null,null,"GO:0005515,GO:0005929,GO:0019899,GO:0046872","protein binding|cilium|enzyme binding|metal ion binding"]
["ANKRA2",6.98084138796774,7.04092931778441,6.39089023580371,5.04208538052286,8.00876563950064,6.53207854524492,6.25855511123061,5.92132426953009,6.87211519470424,6.10245187029044,4.67601452089428,5.96294934671644,8.38388753962548,6.60809251584975,7.27627444219801,7.13618314421258,8.98861230051596,7.17043369664938,7.78117415922323,6.22406201624792,8.30924365843457,7.15413330036696,8.2381263778632,9.81220894605171,7.67084225093935,6.30316943499172,8.93898372779813,7.25055193290801,57763,"ankyrin repeat family A member 2","protein_coding",null,null,"GO:0005515,GO:0005634,GO:0005829,GO:0005856,GO:0010468,GO:0016020,GO:0019901,GO:0031625,GO:0032991,GO:0042826,GO:0043254,GO:0050750","protein binding|nucleus|cytosol|cytoskeleton|regulation of gene expression|membrane|protein kinase binding|ubiquitin protein ligase binding|protein-containing complex|histone deacetylase binding|regulation of protein-containing complex assembly|low-density lipoprotein particle receptor binding"]
["ANKRD1",0.707788891651634,0.429717872515182,0.28276491279497,0.202198944136178,0.485606592778044,0.254546746763584,0.0983515852938459,0.0886028400671659,0.0302953055050482,0.159544800999383,0.113299495043666,0.0909056722360034,0.0572851881012526,0.071786176079878,0.0420153006330427,0.0285570801644099,0.0289572827842889,0.0836032510740509,0,0,0.0852826928008659,0.0143144559239024,0.0148668820054243,0.0588502441512281,0.0447905324815807,0.128781718963136,0,0.141575202555659,27063,"ankyrin repeat domain 1","protein_coding",null,null,"GO:0001650,GO:0002039,GO:0003677,GO:0003713,GO:0003714,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0005737,GO:0005829,GO:0006357,GO:0031432,GO:0031674,GO:0035914,GO:0035994,GO:0042826,GO:0043065,GO:0043517,GO:0045214,GO:0045892,GO:0045893,GO:0050714,GO:0055008,GO:0061629,GO:0070412,GO:0070528,GO:0071222,GO:0071260,GO:0071347,GO:0071356,GO:0071466,GO:0071560,GO:2000279","fibrillar center|p53 binding|DNA binding|transcription coactivator activity|transcription corepressor activity|protein binding|nucleus|nucleoplasm|transcription regulator complex|cytoplasm|cytosol|regulation of transcription by RNA polymerase II|titin binding|I band|skeletal muscle cell differentiation|response to muscle stretch|histone deacetylase binding|positive regulation of apoptotic process|positive regulation of DNA damage response, signal transduction by p53 class mediator|sarcomere organization|negative regulation of DNA-templated transcription|positive regulation of DNA-templated transcription|positive regulation of protein secretion|cardiac muscle tissue morphogenesis|RNA polymerase II-specific DNA-binding transcription factor binding|R-SMAD binding|protein kinase C signaling|cellular response to lipopolysaccharide|cellular response to mechanical stimulus|cellular response to interleukin-1|cellular response to tumor necrosis factor|cellular response to xenobiotic stimulus|cellular response to transforming growth factor beta stimulus|negative regulation of DNA biosynthetic process","WP5344,WP2882,WP2880,WP516","Cardiomyocyte signaling pathways converging on Titin|Nuclear receptors meta-pathway|Glucocorticoid receptor pathway|Hypertrophy model","R-HSA-1430728,R-HSA-1989781,R-HSA-400206,R-HSA-556833","Metabolism|PPARA activates gene expression|Regulation of lipid metabolism by PPARalpha|Metabolism of lipids"]
["ANKRD10",4.88792396182131,6.17496700566301,6.3254242714329,5.03512094480697,6.03581825872803,5.04343886297868,5.08343059074162,4.93553125808676,6.69882667020449,5.32842755911798,5.68395832981587,5.63400122186964,6.50266236348295,6.22833754533982,6.4732583030731,7.09044664598269,3.98341217352376,4.13075149879831,4.47214032818525,4.78296588242538,3.95495925607274,4.28441715799919,5.67783996340598,4.87931059377485,4.5518739848378,3.88621576732942,5.17740910381617,4.08356612900144,55608,"ankyrin repeat domain 10","protein_coding",null,null,"GO:0005515,GO:0005654","protein binding|nucleoplasm"]
["ANKRD11",14.2194399273773,17.7182461276039,15.4777088994174,14.7281723387319,16.379742325937,16.2252469196814,14.4268067903,13.4561875269327,15.2754548648086,19.0726599514117,15.2108483345372,15.0674708283089,15.3577377868133,16.6492316443212,15.6549103072288,17.47282232147,10.5862290400998,11.6117238835544,8.45633261376701,12.6998777302396,12.7792350916624,11.2449696948573,8.97732363398907,10.253428145374,11.8894682678928,9.94062144655592,8.3992080200953,10.1520330795344,29123,"ankyrin repeat domain 11","protein_coding",null,null,"GO:0005634,GO:0005654,GO:0005829,GO:0042475,GO:0048705,GO:0060325","nucleus|nucleoplasm|cytosol|odontogenesis of dentin-containing tooth|skeletal system morphogenesis|face morphogenesis"]
["ANKRD12",4.56222211428195,3.76290586737524,2.91663985848358,2.51066715341789,5.03755288852137,3.2457605068439,2.7728135527856,2.66717779950736,3.95307590703384,2.19072517655012,1.95728804088874,2.41957227468579,4.46465973084672,2.24518092550535,3.26092640358098,3.55117694649268,2.39575539985924,2.12269247407874,2.1905736893067,2.97906986749041,2.92402058728135,2.25294631118874,4.03207860450146,3.19642483011427,3.21139598739431,1.95484772607262,3.06301540243658,1.79117505019302,23253,"ankyrin repeat domain 12","protein_coding",null,null,"GO:0005654,GO:0005829","nucleoplasm|cytosol"]
["ANKRD13A",47.682414548023,44.5560751733887,38.2208263896536,41.3816145098516,48.4462876522839,47.1677066805102,38.2891005955305,41.3275477833917,68.5591302278652,56.4379799798861,46.8889066104656,59.260830389102,68.4951954571432,56.3823356451144,48.227691510861,60.1764966885474,74.5304307203122,69.9096920421546,60.5788683727411,74.053559560403,77.4524211782427,69.1846541922955,71.1585959700489,77.569431986021,76.0111326819662,68.0324961142552,66.9800161645141,65.1976951403953,88455,"ankyrin repeat domain 13A","protein_coding",null,null,"GO:0002091,GO:0005737,GO:0005770,GO:0005886,GO:0048471,GO:0140036,GO:1905667","negative regulation of receptor internalization|cytoplasm|late endosome|plasma membrane|perinuclear region of cytoplasm|ubiquitin-dependent protein binding|negative regulation of protein localization to endosome"]
["ANKRD13B",1.16670957413519,1.96549969194354,1.9454700928442,2.09314595424839,1.19110692340241,1.77149212759253,1.52177506727425,1.83279159337902,1.84498671467221,3.03005197387795,3.13882173970967,2.60456626374142,1.42417342640614,2.54559592524425,1.86776889851196,1.98678936600345,1.0714942880388,1.83141646651916,1.21241452147106,1.29496706128079,1.16694416753467,1.50073692942068,0.888203361844315,0.884654509947725,1.2200051152821,1.42847384267633,0.752668951103029,1.14595432042791,124930,"ankyrin repeat domain 13B","protein_coding",null,null,"GO:0002091,GO:0005737,GO:0005769,GO:0005770,GO:0005886,GO:0043231,GO:0048471,GO:0140036","negative regulation of receptor internalization|cytoplasm|early endosome|late endosome|plasma membrane|intracellular membrane-bounded organelle|perinuclear region of cytoplasm|ubiquitin-dependent protein binding"]
["ANKRD13C",6.13404864120152,5.38535823242554,4.94469483684922,4.33271288353593,5.51033766126292,4.87760977441467,4.8376607624335,4.11390582666581,5.72702210333178,4.54351013439084,4.43649010184355,5.66888302869955,6.24794021630021,4.77021981511355,6.16066359475946,5.74713042065708,5.70980843258475,4.74298596732525,5.11530528735384,5.66722677793499,5.8624848552955,5.33863866268866,7.51690288198469,6.84891151993423,5.86987082686017,4.86638864358821,6.51576655005923,4.93436200330592,81573,"ankyrin repeat domain 13C","protein_coding",null,null,"GO:0005102,GO:0005515,GO:0005737,GO:0005783,GO:0005789,GO:0006621,GO:0010469,GO:0048471,GO:2000209","signaling receptor binding|protein binding|cytoplasm|endoplasmic reticulum|endoplasmic reticulum membrane|protein retention in ER lumen|regulation of signaling receptor activity|perinuclear region of cytoplasm|regulation of anoikis"]
["ANKRD13D",10.7448624767738,12.1252412500835,12.5602293807209,13.9981740879356,10.2939802286561,12.4280208297152,12.027766736601,12.1640375513392,10.318125879247,18.2354182181221,15.4227542314212,13.3263013480451,10.7654882897548,12.8919249452876,11.2584677911415,11.2369648629697,10.9795175167818,12.7472649959685,12.5487994922623,11.6094170993883,12.658668334539,12.0120379764051,10.4655281611419,11.2866361104319,10.4332889351491,13.3849224388675,10.2155676571331,13.6072599855343,338692,"ankyrin repeat domain 13D","protein_coding",null,null,"GO:0002091,GO:0005737,GO:0005770,GO:0005886,GO:0048471,GO:0140036","negative regulation of receptor internalization|cytoplasm|late endosome|plasma membrane|perinuclear region of cytoplasm|ubiquitin-dependent protein binding"]
["ANKRD16",2.4478838780363,3.5719971659182,3.91333439487365,3.18678767274331,2.73779593866144,3.03722191094381,3.58629212416952,3.25835705673697,2.85777981232978,3.50329957237223,3.54097077029022,2.94741695138153,2.87016132542682,3.77712573586736,4.23304409259018,3.5606783870934,2.75991841095772,3.72032434620857,3.96144782318033,3.14803629658033,2.70943094293439,3.1491280988241,2.96979793933302,2.48756032922601,2.93370909260283,3.39081358013929,2.67319280269117,3.42883575000685,54522,"ankyrin repeat domain 16","protein_coding",null,null,"GO:0005634,GO:0005737,GO:0006400","nucleus|cytoplasm|tRNA modification"]
["ANKRD17",7.56456749065683,7.83830142006065,6.01081473412204,5.44022423084922,8.48045915417222,6.68502393515072,5.8927448797084,5.43996477094486,7.61472601018162,6.55301306919578,4.77822030445192,6.04904166175748,7.50438821650223,5.49956897761696,7.03500545068365,7.60219062799053,5.7676952006787,5.08501547979666,4.22001075550757,6.42823384086224,5.9794716541306,5.30424393084135,5.95838526596364,5.90967290867364,6.31322124434851,4.7400853719693,5.16756186260555,4.44427896063682,26057,"ankyrin repeat domain 17","protein_coding",null,null,"GO:0000785,GO:0001673,GO:0001955,GO:0003682,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006275,GO:0016020,GO:0031965,GO:0042742,GO:0043123,GO:0045087,GO:0045787,GO:0051151,GO:1900087,GO:1900245,GO:1900246","chromatin|male germ cell nucleus|blood vessel maturation|chromatin binding|RNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|regulation of DNA replication|membrane|nuclear membrane|defense response to bacterium|positive regulation of canonical NF-kappaB signal transduction|innate immune response|positive regulation of cell cycle|negative regulation of smooth muscle cell differentiation|positive regulation of G1/S transition of mitotic cell cycle|positive regulation of MDA-5 signaling pathway|positive regulation of RIG-I signaling pathway"]
["ANKRD17-DT",0.0362558375726202,0.120698608890724,0.0850956950072289,0.104314375061127,0.0885691957645758,0.127672796656247,0.0338263690414034,0.0622166322596721,0.209693632757706,0.0872975465515974,0.10228955756296,0.173262828555619,0.0430987250761778,0.0950551316081236,0.151729767585366,0.180474217111662,0.01742889582511,0.142571560758987,0.125656568677319,0.0697287646103934,0.0769953026800017,0.043078137363459,0.0894812333211488,0.19481528368152,0.0898621980968724,0.0775115255359835,0.114023351423762,0.0255635116921281,102724832,null,"non_coding"]
["ANKRD18A",0.00319197338487189,0.0212526739396693,0.00599347772531672,6.12257650348911E-3,0.00935718608184186,0,0.00595616468496944,0.0156501957489862,0.0160534626566123,0.0307427949608585,0.0330205307491088,0.0128455617369209,0.00910661515996823,0.00912946750855998,0,0.0272382807252009,0.0122755562306399,0.0236273644243222,0.00590017975522158,0.00613893860128212,0.0120509982327649,9.10226504574972E-3,0.0157559021845527,0.0374216472577969,0.0094937895964511,0.00606589768946819,0.0216216981367207,0.030008243052058,253650,"ankyrin repeat domain 18A","protein_coding"]
["ANKRD18B",0.385172159672233,0.333056935181717,0.465714239897757,0.386193542050836,0.216700193802689,0.268532091585889,0.397476313684064,0.228908253908099,0.252417153574752,0.247313439089756,0.279906660059978,0.187886155216795,0.288596303770545,0.22811809753203,0.417909279515933,0.287734685181129,0.230047086332427,0.291588736696895,0.194173267934884,0.336717924796455,0.209314020506419,0.238532944893434,0.4378633098112,0.256569991685507,0.312437964181972,0.144175054738745,0.248482683130012,0.0877833687203742,441459,"ankyrin repeat domain 18B","protein_coding"]
["ANKRD2",0.0357272567730193,0.152921469543176,0.167710137144797,0.0342645186030255,0.192011442693328,0.234848003604132,0.0499998118932076,0.19268720133891,0.341399383772926,0.602173732309859,0.319194485291177,0.287556710055129,0.152893369832866,0.52795426251457,0.199356893659765,0.186311765552429,0.223272355994169,0.214871620553696,0.660397853318042,0.343560877984278,0.168606163147283,0.169800371794469,0.617236684983325,0.383950068700358,0.495891647443523,0.475262480997895,0.51858915298099,0.453434694467529,26287,"ankyrin repeat domain 2","protein_coding",null,null,"GO:0000122,GO:0000791,GO:0005515,GO:0005634,GO:0005829,GO:0006357,GO:0006936,GO:0007517,GO:0008307,GO:0016605,GO:0031674,GO:0043231,GO:0043422,GO:0043619,GO:0045662,GO:0061629","negative regulation of transcription by RNA polymerase II|euchromatin|protein binding|nucleus|cytosol|regulation of transcription by RNA polymerase II|muscle contraction|muscle organ development|structural constituent of muscle|PML body|I band|intracellular membrane-bounded organelle|protein kinase B binding|regulation of transcription from RNA polymerase II promoter in response to oxidative stress|negative regulation of myoblast differentiation|RNA polymerase II-specific DNA-binding transcription factor binding","WP5344,WP5407","Cardiomyocyte signaling pathways converging on Titin|15q11q13 copy number variation"]
["ANKRD20A1",0,0,0,0,0,0,0,0,0,0,0,0,6.58154600136343E-3,0,0,0,0.0133077114721122,0,0,0,0.0326606803837291,0.00657840208056109,0,0.00676135667719501,0,0.0065759314489806,0.00669705632732831,0,84210,"ankyrin repeat domain 20 family member A1","protein_coding",null,null,"GO:0005886","plasma membrane"]
["ANKRD20A4-ANKRD20A20P",0,0,0.0230749575519944,0,0,0.00577006150377145,0,0,0,0,0.00577860998769554,0.00618194488649974,0.0116868573855986,0.0234323693062196,0.00571441289667552,0.00582598284639774,0,0,0.0227157593037822,0.0118174917911619,0,0,0.01819812089563,0,6.09186635833368E-3,0.00583844380984259,0.023783938358736,0.0404362272172877,110006327,"ANKRD20A4-ANKRD20A20P readthrough","non_coding"]
["ANKRD22",0.0558967656511002,0,0,0.00670103143752793,0,0.0131224778730147,0,0.0274060970658764,0.00702807113193836,0,0,0,0,0.00666134034126396,0,0,0,6.46491357450109E-3,0.00645762286584321,0.00671893941003467,0,0.00664149199164993,0.00689780165622334,0,0,0.00663899766557269,0,0,118932,"ankyrin repeat domain 22","protein_coding"]
["ANKRD23",0.385982958089781,0.386978904544438,0.421138067682447,0.510248275381239,0.417941033914775,0.342865361298989,0.369851549739462,0.255738976587053,0.32528763592785,0.612886885066234,0.274698659616319,0.461798938680832,0.476194210686883,0.407769927438254,0.213436860026989,0.336297194041406,0.541604286751038,0.308874756290095,0.269960624016968,0.371169398229415,0.354464442988119,0.386722975250631,0.391348805731024,0.295560775337679,0.475754959305129,0.158595993769532,0.423982757193359,0.254988774262399,200539,"ankyrin repeat domain 23","protein_coding",null,null,"GO:0000976,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006631,GO:0014704,GO:0015629,GO:0031432,GO:0031674,GO:0035994,GO:0045944,GO:0060297","transcription cis-regulatory region binding|protein binding|nucleus|nucleoplasm|cytosol|fatty acid metabolic process|intercalated disc|actin cytoskeleton|titin binding|I band|response to muscle stretch|positive regulation of transcription by RNA polymerase II|regulation of sarcomere organization","WP5221,WP5344","2q11.2 copy number variation syndrome|Cardiomyocyte signaling pathways converging on Titin"]
["ANKRD24",0.24465615570197,0.414221300117345,0.349131772886438,0.380115977884299,0.20081686521259,0.225149706123656,0.269349140961104,0.287890876239293,0.177185468029162,0.381729082937021,0.547602229062701,0.255990197002698,0.223359201382266,0.354539531454224,0.200225393468775,0.301562559187611,0.164655451664158,0.253536331084373,0.122102875920026,0.169391914463767,0.267866193700789,0.218601411667801,0.125595332824914,0.143413419446403,0.179492767365831,0.232467353365215,0.142049561054331,0.202404482724337,170961,"ankyrin repeat domain 24","protein_coding",null,null,"GO:0003779,GO:0005886,GO:0007605,GO:0032420,GO:0060088","actin binding|plasma membrane|sensory perception of sound|stereocilium|auditory receptor cell stereocilium organization"]
["ANKRD26",0.466384787111475,0.454601400716009,0.350286985001462,0.388707019519155,0.468637254858022,0.338740033685963,0.346565942614758,0.323777322636426,0.480744083453072,0.29892886971801,0.3299263184961,0.384512769368735,0.523598302224159,0.375387008343228,0.419917129152694,0.465683461371644,0.44840072182586,0.417781577781191,0.363143994727382,0.555645754860964,0.469804324516529,0.517855776227903,0.731789670295176,0.516129039836836,0.491846387987503,0.345107524413981,0.546367084950439,0.397326193159636,22852,"ankyrin repeat domain 26","protein_coding",null,null,"GO:0005515,GO:0005813,GO:0045599","protein binding|centrosome|negative regulation of fat cell differentiation",null,null,"R-HSA-162582,R-HSA-194315,R-HSA-9012999,R-HSA-9696264,R-HSA-9696270,R-HSA-9696273,R-HSA-9716542","Signal Transduction|Signaling by Rho GTPases|RHO GTPase cycle|RND3 GTPase cycle|RND2 GTPase cycle|RND1 GTPase cycle|Signaling by Rho GTPases, Miro GTPases and RHOBTB3"]
["ANKRD27",6.70256073764393,7.46285754681714,7.00637478473576,6.61480706459938,7.01897686978215,7.72191499834055,7.20108978567638,6.667936808033,7.38424147143749,7.18766476819361,6.50356868506659,6.16201118289573,6.41456451667857,6.45385582214163,7.02523887344825,6.78755789742597,6.33300086723138,6.87695845872283,6.74553493224453,7.36942734371194,7.18158397871732,6.52134572316561,7.16931232737214,7.23156235144178,7.02496517076297,6.72694640901608,6.46240247419862,6.74718282576859,84079,"ankyrin repeat domain 27","protein_coding",null,null,"GO:0000149,GO:0005085,GO:0005096,GO:0005515,GO:0005764,GO:0005769,GO:0005770,GO:0005829,GO:0005886,GO:0010976,GO:0015031,GO:0016020,GO:0030133,GO:0030659,GO:0031267,GO:0032456,GO:0035544,GO:0035646,GO:0042470,GO:0043005,GO:0043231,GO:0045022,GO:0048812,GO:0050775,GO:0097422","SNARE binding|guanyl-nucleotide exchange factor activity|GTPase activator activity|protein binding|lysosome|early endosome|late endosome|cytosol|plasma membrane|positive regulation of neuron projection development|protein transport|membrane|transport vesicle|cytoplasmic vesicle membrane|small GTPase binding|endocytic recycling|negative regulation of SNARE complex assembly|endosome to melanosome transport|melanosome|neuron projection|intracellular membrane-bounded organelle|early endosome to late endosome transport|neuron projection morphogenesis|positive regulation of dendrite morphogenesis|tubular endosome",null,null,"R-HSA-199991,R-HSA-5653656,R-HSA-8876198,R-HSA-9007101","Membrane Trafficking|Vesicle-mediated transport|RAB GEFs exchange GTP for GDP on RABs|Rab regulation of trafficking"]
["ANKRD28",22.1724207222242,19.5485442768523,18.7356672376379,15.4414906635816,24.454032547898,19.2299285305325,18.3474401428822,17.3986124680179,24.7166607910512,16.189402933817,16.4588841002544,19.3676189325276,26.089533978846,21.1962872445277,22.8702173571151,25.4205870428275,20.8369125694355,18.3809901131271,19.5404549630645,22.0265520397804,21.474380715851,19.8749570756135,25.9041333573427,23.3064743017949,22.60028240057,17.9574579363478,22.8509790914956,17.6355885645609,23243,"ankyrin repeat domain 28","protein_coding",null,null,"GO:0005515,GO:0005654,GO:0005829","protein binding|nucleoplasm|cytosol",null,null,"R-HSA-157579,R-HSA-1640170,R-HSA-171319,R-HSA-180786,R-HSA-199977,R-HSA-199991,R-HSA-204005,R-HSA-392499,R-HSA-446203,R-HSA-5653656,R-HSA-597592,R-HSA-73886,R-HSA-948021","Telomere Maintenance|Cell Cycle|Telomere Extension By Telomerase|Extension of Telomeres|ER to Golgi Anterograde Transport|Membrane Trafficking|COPII-mediated vesicle transport|Metabolism of proteins|Asparagine N-linked glycosylation|Vesicle-mediated transport|Post-translational protein modification|Chromosome Maintenance|Transport to the Golgi and subsequent modification"]
["ANKRD29",6.74571076021888,7.60668079918516,6.52894128124792,5.89067661043796,8.07040353716434,7.03886990961304,7.01414878458811,6.44510051008824,7.45933366340919,6.38585146108016,6.556807232,6.15718555603318,8.06953451484916,7.42550816088682,7.88311444047359,8.83231372773483,4.88979523104406,4.17199584385117,5.02043711493281,5.07422843958075,5.05167271037595,5.0073022613094,6.5674953022349,5.28530709748194,4.83109473987205,4.75240963516454,5.52707264838535,4.09293118102918,147463,"ankyrin repeat domain 29","protein_coding",null,null,"GO:0005515","protein binding"]
["ANKRD30B",0,0.00476842720105496,0.00470661329647571,0.00480799317202581,0.0244936570767945,0.0282461519252877,0,0.00983194369352346,0.0100852886096403,0.00482839693964014,0,0.00504374041604507,0,0.00477951479200229,0.00932457852992952,0.00475331723026723,0,0,0.00463334740867084,0,0,0,0,0,0,0,0,0,374860,"ankyrin repeat domain 30B","protein_coding",null,null,"GO:0003674,GO:0005575,GO:0008150","molecular_function|cellular_component|biological_process"]
["ANKRD31",0.0372895691849351,0.0394095189979596,0.0388986469338301,0.00397365190377847,0.0121459324410013,0.0116722685907064,0.0154625916890768,0.0325031424777594,0.0125027505811642,0.00798102992451432,0.0428617248964377,0.00416848942777042,0.0669838715770488,0.011850346312602,0.0269726261364907,0.0392846399433552,0.0239011079851877,0.0345027250436254,0.019146563953599,0.0398427117182812,0.0273745296852866,0.0118150366294737,0.0327226791143063,0.0121436293841106,0.00410774941807713,0.0236211985801839,0.0240562874838092,0.0116855031928049,256006,"ankyrin repeat domain 31","protein_coding",null,null,"GO:0000785,GO:0005634,GO:0007129,GO:0010780,GO:1903343","chromatin|nucleus|homologous chromosome pairing at meiosis|meiotic DNA double-strand break formation involved in reciprocal meiotic recombination|positive regulation of meiotic DNA double-strand break formation","WP5316","Primary ovarian insufficiency"]
["ANKRD33",0.0119592791638168,0.0113752586779381,0.0224555986647292,0.0229392895172872,0.0233722083588153,0.0449214903585543,0.011157899459753,0.0117272318633708,0.0240588273531661,0,0.0337410319645346,0.0240640569805451,0,0.0228034170688521,0,0.0226784265724462,0,0.0442619992376667,0,0.0115002964702368,0,0,0.0354193240324441,0,0.0118567070603415,0,0,0.0112431061479427,341405,"ankyrin repeat domain 33","protein_coding",null,null,"GO:0005634,GO:0005829,GO:0035914","nucleus|cytosol|skeletal muscle cell differentiation"]
["ANKRD33B",0.925296056462026,1.18761840476762,1.02831179282401,0.657540788291125,1.13564719479947,1.21174930679197,0.787884752980964,0.773427431293497,1.07930158130707,0.993181082242005,0.670987911094004,0.939336682456566,1.21125419826477,1.03095399112896,1.06528248286198,1.24727594547697,0.876218276061199,0.794253935451919,0.561532771461977,0.983586874019474,0.965411486450112,0.91396735481865,0.759391479110821,1.01290324067979,1.06656915194456,0.820937595954469,0.633786505667058,0.838443714059985,651746,"ankyrin repeat domain 33B","protein_coding"]
["ANKRD34A",1.04626285914445,1.2013118345307,1.12960937369535,1.05359832410298,1.07348222528321,1.15092171056153,1.14349445042819,1.52428654531962,0.917090215718386,1.3027930558205,1.42672711096538,0.969920930413804,0.710704787227906,0.712488246093605,1.15372206174127,0.96367280222123,0.93406705072138,1.15476942258414,0.808117703055588,0.919870677909887,0.959302224167952,1.08685889766542,0.604979467911337,0.737422764076832,1.27438398858045,0.596482742300381,0.781032357819221,1.18735554547026,284615,"ankyrin repeat domain 34A","protein_coding",null,null,"GO:0034587,GO:0071546","piRNA processing|pi-body"]
["ANKRD35",1.76551573437138,1.82432869942165,2.38081490433681,2.13193345109176,1.48209303276354,2.07992250952799,2.23870845766679,2.14046595077412,1.23503651662214,1.63858456475807,1.74338375281354,1.48559552484122,1.32029653165487,1.70615587411759,1.58221358382723,1.31635472082656,1.60484899170087,1.73752395280723,1.75781531315638,1.5434157930285,1.37098043269587,1.45697211545788,1.58450245845249,1.42693007886179,1.82197947499501,1.83006273251178,1.91813143660348,2.00683587213014,148741,"ankyrin repeat domain 35","protein_coding",null,null,"GO:0003779","actin binding","WP5362","TAR syndrome"]
["ANKRD36",0.397226258071531,0.419808973558289,0.352211882781455,0.296304633650232,0.466322435113239,0.282352161283048,0.319135107184112,0.238039285157933,0.366259454806222,0.342727737866702,0.155653471240403,0.263653117132834,0.364642029560803,0.189353302766571,0.246278798634945,0.345244929453887,0.365996110999542,0.267997527619182,0.323783835968659,0.283833248270443,0.382733574783256,0.330380923974311,0.427552174578839,0.455454035974928,0.464925604930585,0.267350778281365,0.525864897237405,0.280078982378838,375248,"ankyrin repeat domain 36","protein_coding"]
["ANKRD36B",0.292186501654882,0.354408989195513,0.246631966002852,0.161964249703352,0.332661178419737,0.309619228072452,0.202579786790469,0.139315689425418,0.239973404932838,0.237522942689831,0.156299447592806,0.188784154255688,0.216685097693058,0.171227448235079,0.15456304906706,0.246537680436878,0.18813882962525,0.136415076707775,0.161036006967731,0.219107179866017,0.199877777594975,0.208937533861416,0.158781138363422,0.170227374378366,0.151484288951726,0.168106075734829,0.10116510952693,0.153725103093202,57730,"ankyrin repeat domain 36B","protein_coding",null,null,"GO:0005515","protein binding"]
["ANKRD36C",0.23362930684842,0.194051470913634,0.163732344219109,0.164103286483289,0.347262171948433,0.197759842320666,0.138152556421234,0.141975091220906,0.198591052932262,0.17747659415148,0.126877593097758,0.251603345763873,0.419324500060011,0.269794041643955,0.116287465375145,0.212156237647215,0.249929770417864,0.155276301891074,0.222007587670762,0.189855968583352,0.133549171241916,0.231456644492202,0.285868072936334,0.228249436315294,0.260986501113377,0.100051769506951,0.200605122910334,0.179423065543561,400986,"ankyrin repeat domain 36C","protein_coding",null,null,"GO:0008200","ion channel inhibitor activity"]
["ANKRD37",2.88161678899586,3.23924032828904,3.12346684284162,1.63305894420688,2.17584130197542,2.31238719417129,2.54187576264089,2.64588688422147,2.08166139527156,1.91752581747116,2.11872257859839,0.975167261449709,1.19580742508737,2.1228895414098,2.60679965346507,1.93738558433183,8.13519542633252,6.93227216631837,7.55395025570847,6.52450153078101,6.82427300799155,7.61963079471171,6.54301735062832,8.57374851926237,9.0122265760558,7.81590033046331,9.65830719579551,7.95476529267304,353322,"ankyrin repeat domain 37","protein_coding",null,null,"GO:0001673,GO:0005515,GO:0005654,GO:0005737,GO:0005739,GO:0005829","male germ cell nucleus|protein binding|nucleoplasm|cytoplasm|mitochondrion|cytosol"]
["ANKRD39",7.34345325354717,7.87591284580703,8.48310588436077,6.89788550455594,6.52606033554378,7.15127967925497,9.07877750347004,7.46766986126629,5.47149519827721,8.26602069262601,7.36081542841846,5.83753016331645,6.0064354597981,6.85702841559409,5.76140305205345,5.75927795535485,7.2055588417049,6.29133209455792,10.1385692521991,6.77101872290572,8.92775304475732,8.35903245089861,9.33796858876583,8.62103296327464,7.10070537917078,8.93018125679978,8.53904713377084,7.30143951027803,51239,"ankyrin repeat domain 39","protein_coding",null,null,"GO:0003674,GO:0005575,GO:0008150","molecular_function|cellular_component|biological_process","WP5221","2q11.2 copy number variation syndrome"]
["ANKRD40",15.2282265858562,14.2165578430646,13.8088787047403,12.7070982042136,13.3690931991964,12.8418488827937,12.2682465279431,12.5012673036926,14.4798541425586,12.5378865565856,13.4026328335568,14.4326040346846,13.445785073833,13.0556793070931,15.5481011471545,14.0112113178319,11.0590250835984,11.7205414127689,11.2501420506217,13.9392943053798,12.0446368173215,11.6776034647217,12.5918864517162,12.210366220283,12.8069016362374,11.149648341543,11.9912388078034,11.1728321641497,91369,"ankyrin repeat domain 40","protein_coding",null,null,"GO:0003674,GO:0005515,GO:0005575,GO:0008150","molecular_function|protein binding|cellular_component|biological_process"]
["ANKRD42",3.38220465981211,3.33447853472234,2.50052439978251,2.58821830901708,3.23600516834762,3.03527227971442,2.50141378577267,2.89714232217002,2.98510107007741,2.29766057195236,2.43015647658889,2.7195612349201,3.30031748052828,2.73684649514546,2.6738217494308,3.09813721243838,2.67943684510145,2.25221386992879,1.96846472352893,2.66298178589528,2.52637014583469,2.32630398128593,2.49879381405093,2.42115853963898,2.63621555399115,2.14526182444218,2.16770774948985,2.03548224724592,338699,"ankyrin repeat domain 42","protein_coding",null,null,"GO:0005634,GO:0051059,GO:0051092","nucleus|NF-kappaB binding|positive regulation of NF-kappaB transcription factor activity"]
["ANKRD42-DT",0.693922372392397,0.533105439862894,0.551251597320096,0.614318715706521,0.443354594006477,0.275688968304454,0.572720617616356,0.942172774575606,1.12752528112352,0.61692571115513,0.752992931168921,1.04721534303554,0.786820566271908,0.483455019500327,0.670164844750811,0.961610194447111,1.4113091535214,0.642061931515896,0.838672580750877,0.795615559961709,1.05801202058896,0.608860422268169,1.37010829412366,1.38196105510569,1.11133737028555,1.1411845393268,1.26551156965568,0.677458370249012,100506282,"ANKRD42 divergent transcript","non_coding"]
["ANKRD44",0.646574053980929,0.523453517568083,0.301196535784078,0.253247824187508,0.463002099561832,0.482024905423916,0.324648600100885,0.302494514099123,0.412063859643414,0.232930921336227,0.248332100678767,0.35256498167395,0.420094001636967,0.301156251275687,0.355736981923089,0.280786451492962,0.405728036594479,0.342510801571343,0.266857141345922,0.299014025334902,0.305135015332708,0.239268823820023,0.375190395826722,0.371295850561373,0.379234436113845,0.178211775842464,0.269853418166131,0.215765119192901,91526,"ankyrin repeat domain 44","protein_coding",null,null,"GO:0005515","protein binding"]
["ANKRD44-DT",0,0,0,0,0,0,0,0,0,0.00652646816099675,0,0,0,0,0.00630194303109993,0,0,0,0,0,0,0,0,0,0,0,0,0,105373824,null,"non_coding"]
["ANKRD44-IT1",0,0,0,0.0241838908194413,0,0,0,0,0,0,0,0,0.0239804692940229,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,101927547,"ANKRD44 intronic transcript 1","non_coding"]
["ANKRD45",0.0229414597746749,0.0290948460256142,0.0358971059505672,0.0183351626141721,0.0485710956971635,0.0825822660697934,0.0249715372590048,0.00374938732199118,0.107687993752696,0.00736518875019718,0.0143834110729193,0.0384683577547154,0.0618151870184794,0.0182265610188626,0.135124385298324,0.0398786459884561,0.00367613731800547,0.0176891039506561,0.0282706485292744,0.0257378266251626,0.0144355574575461,0.0399789556229276,0.0301976950805216,0.0298842374555172,0.0265354785812863,0.0217985131861952,0.0222000292722926,0.035946044336827,339416,"ankyrin repeat domain 45","protein_coding",null,null,"GO:0003674,GO:0005515,GO:0005737,GO:0008283,GO:0030496,GO:0032154,GO:0090543","molecular_function|protein binding|cytoplasm|cell population proliferation|midbody|cleavage furrow|Flemming body"]
["ANKRD46",1.12447711294177,0.784347152706738,0.709664570825755,0.706976675723283,0.995016928788582,0.750891600598333,0.71107496098229,0.83311994538242,1.13107154504363,0.703960132166877,0.887129794766877,0.911339020040737,0.998076579710817,0.637274915623594,0.929562155372997,0.90624884642259,1.14117866453495,0.838131472239085,1.13741860399428,1.18344580395156,1.22054060113962,1.02135218768275,1.41230210958134,1.31830002309564,1.13960678085233,0.902251322144722,1.40248620617079,1.19809040475607,157567,"ankyrin repeat domain 46","protein_coding",null,null,"GO:0016020","membrane"]
["ANKRD49",2.77371645277726,2.89440672905913,3.00857912459823,2.673068887212,3.55241222852343,3.14835249472742,3.40440777152788,2.97076205769656,2.57328506550122,2.63253993003114,3.16567957243011,3.03442710121111,3.49569841026962,3.11936393700944,2.79241551010517,3.17886518483495,4.27199474042943,3.17688178094826,4.61683908346302,4.29869823025942,4.46072786046088,3.85239046315655,6.93871988422999,4.89350656536211,4.59211093587382,3.99167579123835,5.83721049397343,4.2405379726524,54851,"ankyrin repeat domain 49","protein_coding",null,null,"GO:0005515,GO:0005634,GO:0007283,GO:0030154,GO:0045893","protein binding|nucleus|spermatogenesis|cell differentiation|positive regulation of DNA-templated transcription"]
["ANKRD50",5.06906596918094,5.17450842605379,3.54603810127839,2.71022348623192,5.13593672288148,3.95987564341705,3.65476393736018,2.96247863567423,6.28777428340193,3.82047572578362,2.94716180891935,4.56889226418588,6.45191518403696,4.12250015098572,6.18419579489025,6.24759661767398,3.62084155475788,3.0064261091416,3.16563657296178,4.16078990576384,3.70249746247256,3.51184432831813,5.06127427522012,4.53874856164287,3.82369976063184,2.76088195129766,3.9050408415029,2.74456076437138,57182,"ankyrin repeat domain 50","protein_coding",null,null,"GO:0005515,GO:0005768,GO:0015031,GO:0032456","protein binding|endosome|protein transport|endocytic recycling"]
["ANKRD52",14.2177239298259,14.8154960161284,10.5927266257902,13.0025926207703,13.6654910889316,11.6023719296973,8.63806326094607,10.5351307980605,13.6460679884118,17.3091395726684,12.0795771346559,13.9899636065122,11.5313211296352,10.3943997415179,8.8350320412937,9.94627993220846,11.6013516983481,11.6828719615513,7.57372852805779,11.8642353451319,12.3041508705426,11.4585905269552,8.24998190726023,10.3637673073489,12.2611389752622,9.99555238170011,7.96694207471283,10.5794654615491,283373,"ankyrin repeat domain 52","protein_coding",null,null,"GO:0005515","protein binding"]
["ANKRD53",1.22602555648467,1.09618449407829,1.45030621054679,1.50506222647322,1.0382844895846,1.3431838896249,1.47178039380858,1.45069911832227,1.09345108877908,1.17294762320264,0.976211878724859,1.3650551570753,0.963843264929809,1.50393997879414,0.957765403757476,0.960965663021897,0.762257885057017,0.937769234303434,0.85361628831286,0.856719781257307,0.732884673073946,0.932305983157748,0.766559516380357,0.766587777057841,1.09395918477602,1.07951551429209,0.870028436459617,1.10650164374611,79998,"ankyrin repeat domain 53","protein_coding",null,null,"GO:0000922,GO:0005515,GO:0005737,GO:0005819,GO:0007080,GO:0031116,GO:0051301,GO:0060236,GO:1902412","spindle pole|protein binding|cytoplasm|spindle|mitotic metaphase chromosome alignment|positive regulation of microtubule polymerization|cell division|regulation of mitotic spindle organization|regulation of mitotic cytokinesis"]
["ANKRD54",5.21577204064801,5.09248350116766,4.65029436223025,5.47926270361552,4.38107912722444,4.89787574625045,4.52466262900128,5.0806984789924,4.30132002212308,5.5224759061736,5.3794031135994,4.96253645386752,3.44254324906784,4.25470152989268,4.47800696470213,3.75977160247624,4.88845241303608,5.24784306107613,5.17807683555078,5.666628142506,5.39238547043849,6.15290489729548,4.97861474025834,4.8661927600675,5.00666016118431,5.57295022852864,4.59262394395858,6.05946946520067,129138,"ankyrin repeat domain 54","protein_coding",null,null,"GO:0005515,GO:0005634,GO:0005737,GO:0006913,GO:0019887,GO:0030496,GO:0044877,GO:0045648,GO:0045859,GO:1902531","protein binding|nucleus|cytoplasm|nucleocytoplasmic transport|protein kinase regulator activity|midbody|protein-containing complex binding|positive regulation of erythrocyte differentiation|regulation of protein kinase activity|regulation of intracellular signal transduction"]
["ANKRD55",0.0188592923754033,0.00597943868005423,0,0,0.0368570132747922,0.00590327887524378,0,0,0,0,0.00591202472388534,0.00632467169241472,0,0.00599334212607191,0,0.0119209826246021,0,0,0.00581005340868076,0,0,0.00597548416599474,0,0,0,0.00597323997056424,6.08326361822383E-3,0.023639889232708,79722,"ankyrin repeat domain 55","protein_coding",null,null,"GO:0005515","protein binding"]
["ANKRD6",0.129262559224699,0.132407843172635,0.0684574097249843,0.174829934923036,0.145742228810687,0.171182748055759,0.132970113296223,0.21125743763709,0.443403626065833,0.395834747659066,0.405213213092665,0.410154142714883,0.327806793831587,0.37918776889113,0.456194657309959,0.399107404019138,0.20394358267356,0.165602898660145,0.150099833001934,0.146612165156772,0.16892956855059,0.195329929722697,0.232316738481419,0.178095614677499,0.203731845354556,0.11652408222917,0.246962701144801,0.118405819228279,22881,"ankyrin repeat domain 6","protein_coding",null,null,"GO:0005634,GO:0005737,GO:0043231,GO:0046330,GO:0090090,GO:2000096","nucleus|cytoplasm|intracellular membrane-bounded organelle|positive regulation of JNK cascade|negative regulation of canonical Wnt signaling pathway|positive regulation of Wnt signaling pathway, planar cell polarity pathway"]
["ANKRD60",0,0,0,0,0.00773128230712793,0,0,0,0,0,0,0,0,0.0301725283670048,0,0,0,0,0,0,0,0,0,0,0,0.00751783181502185,0,0,140731,"ankyrin repeat domain 60","protein_coding"]
["ANKRD61",0.32203489739925,0.306308617021246,0.0711383266202386,0.109005956230426,0.0925526311327647,0.142309261093719,0.0176738618287304,0.130029700871584,0.152434565998696,0.109468546779107,0.178150119578498,0.266818475782881,0.0720593722426158,0.0180600499203066,0.158553875192859,0.197571647377804,0.0728510698297641,0.0701100114418136,0.0525232094513488,0.0182162109936147,0.0178795994511068,0.0720249503971481,0.093505687946977,0.0925350817205713,0.0563422720604565,0,0,0.302750064214245,100310846,"ankyrin repeat domain 61","protein_coding",null,null,"GO:0005654","nucleoplasm"]
["ANKRD63",0,0,0,0.00550875331045872,0,0.00539383332986264,0,0,0.00577760460835674,0.0110642618131025,0.00540182442276163,0,0,0,0,0,0,0,0,5.52347501468437E-3,0.00542140848474856,0.00545980739479766,0,0,0.00569465538333898,0,0,0,100131244,"ankyrin repeat domain 63","protein_coding"]
["ANKRD65",1.73520547172972,1.73491085975341,2.16704594994397,2.52333558300311,1.97947909698101,2.07659676343426,2.71076824479702,2.17638463188934,2.78449232349318,2.89938152649042,3.57491284716933,3.32100557388724,2.34093176975141,3.26244528129247,2.76210766796386,2.2574200869486,2.50632218374136,2.95715212032586,3.09554079096275,2.53007899626224,2.48332647490106,2.40118569475594,2.653204298495,2.6414333012937,2.75251679449682,3.22082822077466,2.31172759907286,2.66318215609866,441869,"ankyrin repeat domain 65","protein_coding",{"$nulls":4},"WP5345","1p36 copy number variation syndrome"]
["ANKRD65-AS1",0.425998133656168,0.652814011187097,0.533256393927653,0.749021173342784,0.277511629363141,0.222241087068001,0.706582065173899,0.696220736260873,0.28566425032855,0.478672605121463,1.0683376442221,0.333347402141388,0.495147214097306,1.03790583642092,0.814361533780047,0.5385479209232,0.341309500771798,0.810219976387825,0.50308227162224,0.500681915159001,0.580780878395127,0.562398509740681,0.397189832682234,0.485553265505852,0.539662341898355,0.517212308039444,1.03057642473439,0.600731302854699,105378585,null,"non_coding"]
["ANKRD7",0.595377183413595,0.292915076847744,0.173470782373456,0.531621965515259,0.401225876928939,0.424136874314545,0.421399785537118,0.281846556496976,0.578218092883861,0.0395465199458417,0.2896126658342,0.557688644220112,0.507626171788328,0.391461554251277,0.324581263839424,0.428247455016932,0.375033201635059,0.41791013293934,0.550260290537906,0.434331074917062,0.658835324176276,0.585442713719393,0.689107721896518,0.702012147005796,0.915937393092493,0.390148560453609,0.556268821826676,0.829934755575713,56311,"ankyrin repeat domain 7","protein_coding",null,null,"GO:0005654,GO:0005813","nucleoplasm|centrosome"]
["ANKRD9",3.99581097638976,3.51259118137178,3.09362882154059,3.62573062681442,3.28052531673941,3.0772041851505,2.76795357733808,3.13820216647802,4.19175968642951,5.41598611354946,4.91434834262097,4.93061028124148,3.56400026540462,3.82691162044889,3.43101256272781,3.17622615864097,3.49439569778947,3.71744170353839,3.76721125915048,3.72665651482826,3.37880862170914,3.72185542972272,2.84237797821591,3.08738721634576,3.62508024224149,3.50894978065585,3.12158797957632,3.54382644902657,122416,"ankyrin repeat domain 9","protein_coding",null,null,"GO:0005829,GO:0006878,GO:0016567,GO:0031410,GO:0031466,GO:0043161,GO:1990756","cytosol|intracellular copper ion homeostasis|protein ubiquitination|cytoplasmic vesicle|Cul5-RING ubiquitin ligase complex|proteasome-mediated ubiquitin-dependent protein catabolic process|ubiquitin ligase-substrate adaptor activity",null,null,"R-HSA-392499,R-HSA-597592,R-HSA-8951664","Metabolism of proteins|Post-translational protein modification|Neddylation"]
["ANKS1A",1.69981494224619,2.01003158221086,1.7183147142627,1.63599556232023,1.83159672559853,1.71493943072597,1.70948954839374,1.78687671255169,1.65528027919557,2.01404902761403,1.61745109050993,1.63544935198259,1.58788127113299,1.68179105577488,1.94476122778287,1.75819938611999,1.36028301852417,1.63962664470558,1.29835142283324,1.54387541655233,1.50019316966859,1.40017801222293,1.31750990136665,1.31559782138919,1.49223967283408,1.31193553154558,1.38659280509156,1.38105387436442,23294,"ankyrin repeat and sterile alpha motif domain containing 1A","protein_coding",null,null,"GO:0005515,GO:0005654,GO:0005829,GO:0006929,GO:0016322,GO:0043005,GO:0046875,GO:0048013","protein binding|nucleoplasm|cytosol|substrate-dependent cell migration|neuron remodeling|neuron projection|ephrin receptor binding|ephrin receptor signaling pathway"]
["ANKS1B",0.0730249111334005,0.0108954990162849,0.0268856471849037,0.0370774270010376,0.0335797031599509,0.0161350854034072,0.0280541810808431,0.0379101177489122,0.0878557422738824,0.0275813134435834,0.0350111448218702,0.119567404335343,0.0381272392918674,0.0259369791615494,0.0372854362358458,0.042086273725781,0.0206497142982619,0.00927395389317839,0.0132335647596,0.0220305265007234,0.0243263603707983,0.0136103665695237,0.0424068609206039,0.0503600038922918,0.0709790123074733,0.0312920864154322,0.0332540542589318,0.0242300702557279,56899,"ankyrin repeat and sterile alpha motif domain containing 1B","protein_coding",null,null,"GO:0005654,GO:0005813,GO:0005829,GO:0005886,GO:0014069,GO:0015030,GO:0043197,GO:0046875,GO:0048013","nucleoplasm|centrosome|cytosol|plasma membrane|postsynaptic density|Cajal body|dendritic spine|ephrin receptor binding|ephrin receptor signaling pathway","WP2858","Ectoderm differentiation"]
["ANKS3",5.35748114266697,5.39163266062171,6.48951998774772,6.08396229736048,5.90360105400847,6.22402499127088,5.71136612010326,5.73270693737142,5.07611124144572,6.48629402804527,6.96017955153096,5.73868273017855,4.32603239873401,5.95475084994305,4.96590202900693,4.88595264118167,5.99656268969706,6.79852783247911,6.28175161422666,5.6730348430978,5.84493770705034,6.02990558276295,5.03464950075588,4.68726483162303,5.47889288665594,6.42441843383855,4.85762835634253,6.68212557876415,124401,"ankyrin repeat and sterile alpha motif domain containing 3","protein_coding",null,null,"GO:0005515,GO:0005737,GO:0005929","protein binding|cytoplasm|cilium","WP4352,WP4803","Ciliary landscape|Ciliopathies"]
["ANKS4B",0.00623553440556167,0,0,0,0,0,0,0,0,0.00600561886292969,0,0.00627346569906878,0,0,0,0,0,0,0,0,0,0,0,0.00609194639317016,0,0,0,0,257629,"ankyrin repeat and sterile alpha motif domain containing 4B","protein_coding",null,null,"GO:0005515,GO:0005789,GO:0005886,GO:0005902,GO:0005903,GO:0030154,GO:0034976,GO:0065003,GO:1904106,GO:1904970","protein binding|endoplasmic reticulum membrane|plasma membrane|microvillus|brush border|cell differentiation|response to endoplasmic reticulum stress|protein-containing complex assembly|protein localization to microvillus|brush border assembly","WP5380","5q35 copy number variation"]
["ANKS6",2.89268220565841,3.3202481239832,3.55422396226841,3.25431216969759,2.79056675540433,3.228479677604,3.13390630985256,3.07680982393129,3.24353999947911,4.12575098710591,4.05334701507127,3.92277995321247,3.14175552979275,3.86797836164565,3.44970036784826,3.66442990207823,3.11041743714822,3.37852895686174,2.84635379595373,3.25540888325148,3.42899159070539,3.21037208415294,2.74647918705369,2.92387706379186,3.04809379126754,3.12155262736933,3.02098961669354,3.16279168547501,203286,"ankyrin repeat and sterile alpha motif domain containing 6","protein_coding",null,null,"GO:0001701,GO:0001822,GO:0005515,GO:0005737,GO:0007368,GO:0007507,GO:0097543","in utero embryonic development|kidney development|protein binding|cytoplasm|determination of left/right symmetry|heart development|ciliary inversin compartment","WP4656,WP4352,WP4803","Joubert syndrome|Ciliary landscape|Ciliopathies"]
["ANKUB1",0,0,0,0.00810934105582897,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.00838300430175968,0,0,0,389161,"ankyrin repeat and ubiquitin domain containing 1","protein_coding"]
["ANKZF1",7.52177677244036,9.4151936555578,10.4312617157062,9.96020051811234,7.12610687633641,9.00843700996126,7.8994214143362,8.80794014286671,7.2202381080445,9.87376056300779,11.2031696161449,9.20012186400751,7.27115172164439,10.3016213078707,8.8239074367738,8.90568320084722,7.15831413304253,9.60041039378619,8.08983277905807,7.99496212480484,7.072413585289,8.44720171835136,6.45503802087504,6.76105739618062,7.29638408551756,8.21728300721111,7.30639596543928,8.29177485902827,55139,"ankyrin repeat and zinc finger peptidyl tRNA hydrolase 1","protein_coding",null,null,"GO:0004521,GO:0005515,GO:0005737,GO:0006515,GO:0016020,GO:0030433,GO:0046872,GO:0070301,GO:0072344,GO:0140101","RNA endonuclease activity|protein binding|cytoplasm|protein quality control for misfolded or incompletely synthesized proteins|membrane|ubiquitin-dependent ERAD pathway|metal ion binding|cellular response to hydrogen peroxide|rescue of stalled ribosome|catalytic activity, acting on a tRNA"]
["ANLN",52.8147921072487,35.1474520162052,11.9893959531383,24.5914778573982,35.6015690381348,22.9326204584766,10.9218584555968,17.6858630977805,32.2199466012665,22.7854247214786,11.0510039462147,22.7701985915163,24.8085241181901,7.91487847137837,8.42028425770725,8.24657997360403,58.1546991331305,41.0366736462556,34.033356984196,49.0411387839071,55.329130068026,43.3491609982397,51.8262948401497,60.7545142207329,56.9025232476262,40.9557927159731,46.9347301380706,36.5829386982476,54443,"anillin actin binding protein","protein_coding",null,null,"GO:0000281,GO:0000915,GO:0000921,GO:0002244,GO:0003779,GO:0005654,GO:0005826,GO:0005829,GO:0005938,GO:0007096,GO:0015629,GO:0030496,GO:0031106,GO:0032059,GO:0045296,GO:0090521,GO:1904172","mitotic cytokinesis|actomyosin contractile ring assembly|septin ring assembly|hematopoietic progenitor cell differentiation|actin binding|nucleoplasm|actomyosin contractile ring|cytosol|cell cortex|regulation of exit from mitosis|actin cytoskeleton|midbody|septin ring organization|bleb|cadherin binding|podocyte cell migration|positive regulation of bleb assembly","WP2446,WP4758,WP5199","Retinoblastoma gene in cancer|Nephrotic syndrome|PtdIns(4,5)P2 in cytokinesis pathway","R-HSA-162582,R-HSA-194315,R-HSA-8980692,R-HSA-9012999,R-HSA-9013026,R-HSA-9013106,R-HSA-9716542","Signal Transduction|Signaling by Rho GTPases|RHOA GTPase cycle|RHO GTPase cycle|RHOB GTPase cycle|RHOC GTPase cycle|Signaling by Rho GTPases, Miro GTPases and RHOBTB3"]
["ANO1",3.55665827094877,3.27683965117519,1.87252504470839,2.59060858315902,4.13415586867026,3.25256615448409,1.55722939500513,2.77644135867592,1.60403662650349,1.68813098652221,0.975029308308475,1.20211959292654,1.7862347631641,1.4671469977774,1.3014501453419,1.42824803485263,1.18900660787438,0.920577824434459,0.150391999926666,1.08640313612815,1.54463950442594,0.905948534197312,0.358005185511789,0.663156381790357,1.14772842545506,0.768662645898176,0.242944439000856,0.664363247867261,55107,"anoctamin 1","protein_coding",null,null,"GO:0005102,GO:0005227,GO:0005229,GO:0005247,GO:0005254,GO:0005515,GO:0005654,GO:0005886,GO:0006812,GO:0006821,GO:0007200,GO:0015111,GO:0015705,GO:0016324,GO:0034220,GO:0034605,GO:0034707,GO:0035774,GO:0042802,GO:0042803,GO:0042995,GO:0046872,GO:0050965,GO:0070062,GO:0070254,GO:0072657,GO:0098655,GO:0098793,GO:0106091,GO:1901653,GO:1902476","signaling receptor binding|calcium activated cation channel activity|intracellular calcium activated chloride channel activity|voltage-gated chloride channel activity|chloride channel activity|protein binding|nucleoplasm|plasma membrane|monoatomic cation transport|chloride transport|phospholipase C-activating G protein-coupled receptor signaling pathway|iodide transmembrane transporter activity|iodide transport|apical plasma membrane|monoatomic ion transmembrane transport|cellular response to heat|chloride channel complex|positive regulation of insulin secretion involved in cellular response to glucose stimulus|identical protein binding|protein homodimerization activity|cell projection|metal ion binding|detection of temperature stimulus involved in sensory perception of pain|extracellular exosome|mucus secretion|protein localization to membrane|monoatomic cation transmembrane transport|presynapse|glial cell projection elongation|cellular response to peptide|chloride transmembrane transport","WP1981","Thyroxine (thyroid hormone) production","R-HSA-1643685,R-HSA-2672351,R-HSA-382551,R-HSA-5663205,R-HSA-9679506,R-HSA-9694516,R-HSA-9733458,R-HSA-9772573,R-HSA-9824446,R-HSA-983712","Disease|Stimuli-sensing channels|Transport of small molecules|Infectious disease|SARS-CoV Infections|SARS-CoV-2 Infection|Induction of Cell-Cell Fusion|Late SARS-CoV-2 Infection Events|Viral Infection Pathways|Ion channel transport"]
["ANO10",14.7420207005998,13.8821974066156,15.8197196517984,15.4916931250887,14.5223981855315,14.5085700972394,15.8330548233251,15.2679931713961,12.4118605370243,11.3545667553312,12.4653201263091,11.351236475659,12.2062139585755,12.1900993498164,11.8303187342291,11.8908380541495,12.7750601002906,12.3800847649483,14.6117629679991,12.1226233460825,12.1557138085567,12.7648321737734,11.7676719304536,11.8956764987677,11.8501796411757,12.0301535888325,11.8036362187306,12.0358951000481,55129,"anoctamin 10","protein_coding",null,null,"GO:0005227,GO:0005229,GO:0005254,GO:0005886,GO:0006812,GO:0006821,GO:0016020,GO:0034220,GO:0043231,GO:0098655,GO:1902476","calcium activated cation channel activity|intracellular calcium activated chloride channel activity|chloride channel activity|plasma membrane|monoatomic cation transport|chloride transport|membrane|monoatomic ion transmembrane transport|intracellular membrane-bounded organelle|monoatomic cation transmembrane transport|chloride transmembrane transport",null,null,"R-HSA-1643685,R-HSA-2672351,R-HSA-382551,R-HSA-5663205,R-HSA-9679506,R-HSA-9694516,R-HSA-9733458,R-HSA-9772573,R-HSA-9824446,R-HSA-983712","Disease|Stimuli-sensing channels|Transport of small molecules|Infectious disease|SARS-CoV Infections|SARS-CoV-2 Infection|Induction of Cell-Cell Fusion|Late SARS-CoV-2 Infection Events|Viral Infection Pathways|Ion channel transport"]
["ANO2",2.13092610555281E-3,0,0,0,0,0,0,0,0,0.00410470993588064,0.00200401280759054,0.0021438887128122,0.00202649183204036,0.00609473147112956,0.011890496147533,0.00404088328018132,0.00204875637090423,0,0,0.00409828746939348,0.00201127826236561,0.00202552380267078,0.00210369318495728,0,0,0,0,0,57101,"anoctamin 2","protein_coding","hsa04740","Olfactory transduction","GO:0005229,GO:0005515,GO:0005654,GO:0005886,GO:0034220,GO:0034707,GO:0046983,GO:1902476","intracellular calcium activated chloride channel activity|protein binding|nucleoplasm|plasma membrane|monoatomic ion transmembrane transport|chloride channel complex|protein dimerization activity|chloride transmembrane transport",null,null,"R-HSA-1643685,R-HSA-2672351,R-HSA-381753,R-HSA-382551,R-HSA-5663205,R-HSA-9679506,R-HSA-9694516,R-HSA-9709957,R-HSA-9733458,R-HSA-9772573,R-HSA-9824446,R-HSA-983712","Disease|Stimuli-sensing channels|Olfactory Signaling Pathway|Transport of small molecules|Infectious disease|SARS-CoV Infections|SARS-CoV-2 Infection|Sensory Perception|Induction of Cell-Cell Fusion|Late SARS-CoV-2 Infection Events|Viral Infection Pathways|Ion channel transport"]
["ANO3",0.00692250006041168,0.00219481536210174,0,0,0.00450958377339237,0,0.00215287668055842,0,0.0162472255597609,0.00444483655956943,0.0108503518301747,6.96461022523737E-3,0.0131664723550644,0.013199512602258,0.0042919242214887,2.18786053305486E-3,0.0288407794209212,0.00427009699887437,2.13264073073301E-3,0.00443788191130179,0.00435587570945472,0.00658009144935425,9.1120420440711E-3,0.00225436434323528,0.00228770910066853,0,0.00446585077811056,0.0108465850271627,63982,"anoctamin 3","protein_coding",null,null,"GO:0005229,GO:0005254,GO:0005886,GO:0016048,GO:0017128,GO:0034220,GO:0046983,GO:0050982,GO:0051649,GO:0061590,GO:0061591,GO:1902476","intracellular calcium activated chloride channel activity|chloride channel activity|plasma membrane|detection of temperature stimulus|phospholipid scramblase activity|monoatomic ion transmembrane transport|protein dimerization activity|detection of mechanical stimulus|establishment of localization in cell|calcium activated phosphatidylcholine scrambling|calcium activated galactosylceramide scrambling|chloride transmembrane transport",null,null,"R-HSA-1643685,R-HSA-2672351,R-HSA-382551,R-HSA-5663205,R-HSA-9679506,R-HSA-9694516,R-HSA-9733458,R-HSA-9772573,R-HSA-9824446,R-HSA-983712","Disease|Stimuli-sensing channels|Transport of small molecules|Infectious disease|SARS-CoV Infections|SARS-CoV-2 Infection|Induction of Cell-Cell Fusion|Late SARS-CoV-2 Infection Events|Viral Infection Pathways|Ion channel transport"]
["ANO4",0.902566037114954,0.958244173549044,0.674308640780933,0.722360444562357,1.13038602813252,0.865461606571935,0.693831391116992,0.804027422774081,1.57276996299138,1.42942579472481,1.18654238627211,1.38126892687763,1.73177608110739,1.40586480558602,0.886670456651103,1.56388900280231,1.72024763449203,1.52319827204435,0.910538528070168,1.64722697282121,1.57179428082017,1.44094693486272,0.941230327388929,1.70767700326821,1.9219831178432,1.38907054670343,0.977958139305839,1.15027765669927,121601,"anoctamin 4","protein_coding",null,null,"GO:0005229,GO:0005886,GO:0006821,GO:0017128,GO:0034220,GO:0046983,GO:0051649,GO:0061589,GO:0061590,GO:0061591,GO:1902476","intracellular calcium activated chloride channel activity|plasma membrane|chloride transport|phospholipid scramblase activity|monoatomic ion transmembrane transport|protein dimerization activity|establishment of localization in cell|calcium activated phosphatidylserine scrambling|calcium activated phosphatidylcholine scrambling|calcium activated galactosylceramide scrambling|chloride transmembrane transport",null,null,"R-HSA-1643685,R-HSA-2672351,R-HSA-382551,R-HSA-5663205,R-HSA-9679506,R-HSA-9694516,R-HSA-9733458,R-HSA-9772573,R-HSA-9824446,R-HSA-983712","Disease|Stimuli-sensing channels|Transport of small molecules|Infectious disease|SARS-CoV Infections|SARS-CoV-2 Infection|Induction of Cell-Cell Fusion|Late SARS-CoV-2 Infection Events|Viral Infection Pathways|Ion channel transport"]
["ANO5",0.222114005347933,0.189412035676058,0.16178941416135,0.132219470705409,0.190845918431542,0.226557091699653,0.175073925803649,0.217804301173773,0.269640700368131,0.140157271357993,0.252103046046515,0.30437493751227,0.360545112353423,0.324939784380888,0.45942856793938,0.359468687024796,0.224594808013674,0.145277326237737,0.162810259235042,0.195176646814523,0.198799098031094,0.189286767637,0.211714199776067,0.1309478546695,0.182241916504116,0.16374433651372,0.188995134840479,0.147609093842305,203859,"anoctamin 5","protein_coding",null,null,"GO:0005229,GO:0005254,GO:0005789,GO:0005886,GO:0006821,GO:0031982,GO:0034220,GO:0046983,GO:1902476","intracellular calcium activated chloride channel activity|chloride channel activity|endoplasmic reticulum membrane|plasma membrane|chloride transport|vesicle|monoatomic ion transmembrane transport|protein dimerization activity|chloride transmembrane transport",null,null,"R-HSA-1643685,R-HSA-2672351,R-HSA-382551,R-HSA-5663205,R-HSA-9679506,R-HSA-9694516,R-HSA-9733458,R-HSA-9772573,R-HSA-9824446,R-HSA-983712","Disease|Stimuli-sensing channels|Transport of small molecules|Infectious disease|SARS-CoV Infections|SARS-CoV-2 Infection|Induction of Cell-Cell Fusion|Late SARS-CoV-2 Infection Events|Viral Infection Pathways|Ion channel transport"]
["ANO6",15.0628878810357,13.8829101635584,10.7377740803048,9.18748761924208,15.4383255648595,12.8742425137163,11.6682727966057,10.7975804363049,15.3467229865624,11.4619983994333,9.44150676303808,11.8791856924206,15.6505048164715,11.2533092586759,14.2934359402615,14.6398394138191,11.8767219278781,9.91509595776609,9.05411912535288,12.7559623679492,11.5254025168924,10.3813150270744,11.578975812827,12.2840500614,12.613971200567,9.23028903644382,10.2792107252399,8.34893232774988,196527,"anoctamin 6","protein_coding",null,null,"GO:0002543,GO:0005227,GO:0005229,GO:0005244,GO:0005247,GO:0005254,GO:0005515,GO:0005829,GO:0005886,GO:0006812,GO:0006821,GO:0007596,GO:0009986,GO:0016020,GO:0017121,GO:0017128,GO:0030501,GO:0032060,GO:0034220,GO:0034707,GO:0034767,GO:0035579,GO:0035590,GO:0035725,GO:0043065,GO:0045794,GO:0046872,GO:0046931,GO:0046983,GO:0060100,GO:0061589,GO:0061590,GO:0070062,GO:0070588,GO:0070821,GO:0090026,GO:0097045,GO:1902476,GO:1903766,GO:2000353","activation of blood coagulation via clotting cascade|calcium activated cation channel activity|intracellular calcium activated chloride channel activity|voltage-gated monoatomic ion channel activity|voltage-gated chloride channel activity|chloride channel activity|protein binding|cytosol|plasma membrane|monoatomic cation transport|chloride transport|blood coagulation|cell surface|membrane|plasma membrane phospholipid scrambling|phospholipid scramblase activity|positive regulation of bone mineralization|bleb assembly|monoatomic ion transmembrane transport|chloride channel complex|positive regulation of monoatomic ion transmembrane transport|specific granule membrane|purinergic nucleotide receptor signaling pathway|sodium ion transmembrane transport|positive regulation of apoptotic process|negative regulation of cell volume|metal ion binding|pore complex assembly|protein dimerization activity|positive regulation of phagocytosis, engulfment|calcium activated phosphatidylserine scrambling|calcium activated phosphatidylcholine scrambling|extracellular exosome|calcium ion transmembrane transport|tertiary granule membrane|positive regulation of monocyte chemotaxis|phosphatidylserine exposure on blood platelet|chloride transmembrane transport|positive regulation of potassium ion export across plasma membrane|positive regulation of endothelial cell apoptotic process","WP5256","COVID-19 and endothelial cell senescence","R-HSA-1643685,R-HSA-168249,R-HSA-168256,R-HSA-2672351,R-HSA-382551,R-HSA-5663205,R-HSA-6798695,R-HSA-9679506,R-HSA-9694516,R-HSA-9733458,R-HSA-9772573,R-HSA-9824446,R-HSA-983712","Disease|Innate Immune System|Immune System|Stimuli-sensing channels|Transport of small molecules|Infectious disease|Neutrophil degranulation|SARS-CoV Infections|SARS-CoV-2 Infection|Induction of Cell-Cell Fusion|Late SARS-CoV-2 Infection Events|Viral Infection Pathways|Ion channel transport"]
["ANO7",1.32267505499744,0.49673404624801,0.87519913122825,0.833199187562001,1.02538528813737,0.719569399108478,1.06100451820967,1.70860863323438,1.23224495838884,0.902545671941599,0.550804171993924,1.62534557737671,0.761209479404478,1.05626930749726,0.785254278896394,0.79595816051227,0.703877460400287,0.338696857284427,0.708205851091514,0.966841147609313,0.515947680992142,0.640223954793118,1.00221573569792,0.963202574696771,1.34036391576692,0.732734740723729,1.1193469403588,0.692854635139764,50636,"anoctamin 7","protein_coding",null,null,"GO:0005229,GO:0005254,GO:0005783,GO:0005829,GO:0005886,GO:0006821,GO:0034220,GO:0046983,GO:0061588,GO:0070161,GO:1902476","intracellular calcium activated chloride channel activity|chloride channel activity|endoplasmic reticulum|cytosol|plasma membrane|chloride transport|monoatomic ion transmembrane transport|protein dimerization activity|calcium activated phospholipid scrambling|anchoring junction|chloride transmembrane transport","WP5224","2q37 copy number variation syndrome","R-HSA-1643685,R-HSA-2672351,R-HSA-382551,R-HSA-5663205,R-HSA-9679506,R-HSA-9694516,R-HSA-9733458,R-HSA-9772573,R-HSA-9824446,R-HSA-983712","Disease|Stimuli-sensing channels|Transport of small molecules|Infectious disease|SARS-CoV Infections|SARS-CoV-2 Infection|Induction of Cell-Cell Fusion|Late SARS-CoV-2 Infection Events|Viral Infection Pathways|Ion channel transport"]
["ANO8",2.45349982979458,3.37258482766223,3.35917379187119,3.24576294828007,2.71291159108155,2.74858549710033,2.80112718629025,2.49031162727701,3.56111943412734,5.08363409738535,4.43258832854966,3.88668622991205,3.27986287302875,3.78566763772616,3.57272622269239,3.80062816898691,2.63823387762249,3.20607064897282,2.74496147246817,3.11991336348902,2.59505077438536,2.61854542218326,2.177805330096,2.54418650313662,2.37911335338291,2.61756198259782,2.00453857126813,2.92874163035351,57719,"anoctamin 8","protein_coding",null,null,"GO:0005229,GO:0005254,GO:0005788,GO:0005886,GO:0006821,GO:0034220,GO:1902476","intracellular calcium activated chloride channel activity|chloride channel activity|endoplasmic reticulum lumen|plasma membrane|chloride transport|monoatomic ion transmembrane transport|chloride transmembrane transport",null,null,"R-HSA-1643685,R-HSA-2672351,R-HSA-381426,R-HSA-382551,R-HSA-392499,R-HSA-5663205,R-HSA-597592,R-HSA-8957275,R-HSA-9679506,R-HSA-9694516,R-HSA-9733458,R-HSA-9772573,R-HSA-9824446,R-HSA-983712","Disease|Stimuli-sensing channels|Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)|Transport of small molecules|Metabolism of proteins|Infectious disease|Post-translational protein modification|Post-translational protein phosphorylation|SARS-CoV Infections|SARS-CoV-2 Infection|Induction of Cell-Cell Fusion|Late SARS-CoV-2 Infection Events|Viral Infection Pathways|Ion channel transport"]
["ANO9",0,0,0,0,0.00530630113222902,0,0,5.32497595085371E-3,0,0,5.10692224335623E-3,0,0.0206568264909835,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,338440,"anoctamin 9","protein_coding",null,null,"GO:0005229,GO:0005254,GO:0005515,GO:0005886,GO:0006629,GO:0006821,GO:0017128,GO:0034220,GO:0051649,GO:0061589,GO:0061590,GO:0061591,GO:1902476,GO:1902939","intracellular calcium activated chloride channel activity|chloride channel activity|protein binding|plasma membrane|lipid metabolic process|chloride transport|phospholipid scramblase activity|monoatomic ion transmembrane transport|establishment of localization in cell|calcium activated phosphatidylserine scrambling|calcium activated phosphatidylcholine scrambling|calcium activated galactosylceramide scrambling|chloride transmembrane transport|negative regulation of intracellular calcium activated chloride channel activity",null,null,"R-HSA-1643685,R-HSA-2672351,R-HSA-382551,R-HSA-5663205,R-HSA-9679506,R-HSA-9694516,R-HSA-9733458,R-HSA-9772573,R-HSA-9824446,R-HSA-983712","Disease|Stimuli-sensing channels|Transport of small molecules|Infectious disease|SARS-CoV Infections|SARS-CoV-2 Infection|Induction of Cell-Cell Fusion|Late SARS-CoV-2 Infection Events|Viral Infection Pathways|Ion channel transport"]
["ANOS1",0.0121206003755589,0.00768580127700016,0.00379308448668313,0.00774957412649364,0.0157916539690556,0.0113818614285275,0.00753894046231518,0,0.142236277719669,0.0933895336131118,0.0911897914245336,0.134137641361428,0.176740946802201,0.130962430342367,0.120235632507028,0.195366895099594,0.0155376307505627,0.041120803698243,0.0261382738481657,0.0194257106144437,0.0228800989378822,0.0614457460522433,0.0438742366137299,0.0434188139739838,0.0480665786223199,0.00383891681561442,0.015638509829103,0.0455790670098256,3730,"anosmin 1","protein_coding",null,null,"GO:0004867,GO:0005201,GO:0005515,GO:0005576,GO:0005615,GO:0005886,GO:0006935,GO:0007155,GO:0007411,GO:0008201,GO:0009986,GO:0030182,GO:0031012","serine-type endopeptidase inhibitor activity|extracellular matrix structural constituent|protein binding|extracellular region|extracellular space|plasma membrane|chemotaxis|cell adhesion|axon guidance|heparin binding|cell surface|neuron differentiation|extracellular matrix","WP5053,WP5074","Development of ureteric collection system|Kallmann syndrome","R-HSA-162582,R-HSA-190236,R-HSA-190242,R-HSA-190373,R-HSA-5654726,R-HSA-5654736,R-HSA-9006934","Signal Transduction|Signaling by FGFR|FGFR1 ligand binding and activation|FGFR1c ligand binding and activation|Negative regulation of FGFR1 signaling|Signaling by FGFR1|Signaling by Receptor Tyrosine Kinases"]
["ANP32A",33.1428875843153,33.4894049026439,47.4411150186948,40.6860264172843,29.1256605972944,33.9550407299957,47.7023615201671,39.3247728076792,39.6824424929844,32.0166113305062,47.1586511437362,45.1151066430757,37.1183954421607,40.7294168682451,49.6450955545579,39.2177658939827,41.8279642401861,45.5900406164329,52.675734842511,41.7190127843645,39.9470773944679,44.220463636492,50.2677917630212,45.676954663311,39.7479874115335,43.9414250130987,49.8181394591959,46.1763769470002,8125,"acidic nuclear phosphoprotein 32 family member A","protein_coding",null,null,"GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005783,GO:0006913,GO:0035556,GO:0042393,GO:0042981,GO:0048471","RNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|endoplasmic reticulum|nucleocytoplasmic transport|intracellular signal transduction|histone binding|regulation of apoptotic process|perinuclear region of cytoplasm","WP4754","IL-18 signaling pathway","R-HSA-450520,R-HSA-450531,R-HSA-8953854","HuR (ELAVL1) binds and stabilizes mRNA|Regulation of mRNA stability by proteins that bind AU-rich elements|Metabolism of RNA"]
["ANP32A-IT1",0,0.0234439192868691,0.00771333730422123,0,0.0240845585069047,0.0154302101902135,0,0.0161128805974019,0.041320174378266,0,0,0.0247974936456028,0.0234396114068673,0.00783281043480535,7.64069776827659E-3,0,0.00789904544100536,0.0380091992844029,0.0303730679871053,0.00790053893444492,0.0232636421995657,0.0156189430684458,0,0.0401333195027043,0.0325815516172019,0.0156130771068451,0.0079503305074501,0.0463431172035288,80035,"ANP32A intronic transcript 1","non_coding"]
["ANP32B",118.730949370605,127.542176995384,166.930256734967,154.313575077221,108.683337762599,128.716987377167,167.75648283314,140.632363514564,125.131664487196,109.416260723386,144.463445581515,130.096458147179,114.727108940685,135.706271792033,140.475027059215,122.484744445025,127.172165478784,149.834821447011,160.820648559823,129.136402552956,125.343322426342,143.992615946694,140.021066565141,126.296671638962,115.225733825609,148.498145138581,140.451112369269,154.717543644686,10541,"acidic nuclear phosphoprotein 32 family member B","protein_coding",null,null,"GO:0001944,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0006334,GO:0006919,GO:0021591,GO:0042393,GO:0042981,GO:0045596,GO:0046827,GO:0048839,GO:0060021,GO:0070062,GO:0070063","vasculature development|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|nucleosome assembly|activation of cysteine-type endopeptidase activity involved in apoptotic process|ventricular system development|histone binding|regulation of apoptotic process|negative regulation of cell differentiation|positive regulation of protein export from nucleus|inner ear development|roof of mouth development|extracellular exosome|RNA polymerase binding"]
["ANP32D",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.0240212281458147,0,0,0,0,0,0,0,0,0,0,0,0,23519,"acidic nuclear phosphoprotein 32 family member D","protein_coding"]
["ANP32E",20.4542135704608,15.5757333162249,14.7096960037135,14.5574127358535,16.8764374351711,12.9322349149059,12.9260122302579,13.4748709693436,17.3419479889164,10.0312143597744,11.4297824276585,14.9229198380384,16.5676456388453,10.7475649505363,13.0034735856492,11.0168782628684,25.5043572094035,23.4236921895338,23.9119609152603,25.6322023785434,22.7790739114161,23.1120917619572,31.9830958653545,28.0632449501797,26.8816970473415,20.886742600455,28.2187348633186,19.9863318124883,81611,"acidic nuclear phosphoprotein 32 family member E","protein_coding",null,null,"GO:0000812,GO:0005515,GO:0005634,GO:0006325,GO:0006457,GO:0019212,GO:0031410,GO:0042393,GO:0042981,GO:0044183,GO:0140713","Swr1 complex|protein binding|nucleus|chromatin organization|protein folding|phosphatase inhibitor activity|cytoplasmic vesicle|histone binding|regulation of apoptotic process|protein folding chaperone|histone chaperone activity"]
["ANPEP",23.2345658739789,30.8167707038525,27.5447358046256,28.1662616886573,24.4646630026166,31.7089156398513,27.4761858528412,29.0007692423389,13.1687452114849,18.6375950603642,17.0019571719994,14.3703719742314,13.7023747235834,16.5906960852897,16.5805101259433,17.5109444262171,11.2506352071689,15.6931552336699,13.8196899946489,15.0649804528066,11.5654811054649,13.8356539725488,10.6592095998073,9.76532690482394,11.6817130635317,13.9981843783193,10.4838351060715,13.8983198165077,290,"alanyl aminopeptidase%2C membrane","protein_coding","hsa00480,hsa04640,hsa04614","Glutathione metabolism|Hematopoietic cell lineage|Renin-angiotensin system","GO:0001525,GO:0001618,GO:0004177,GO:0005615,GO:0005737,GO:0005765,GO:0005793,GO:0005886,GO:0006508,GO:0008237,GO:0008270,GO:0009897,GO:0030154,GO:0030667,GO:0038023,GO:0042277,GO:0043171,GO:0046718,GO:0070006,GO:0070062","angiogenesis|virus receptor activity|aminopeptidase activity|extracellular space|cytoplasm|lysosomal membrane|endoplasmic reticulum-Golgi intermediate compartment|plasma membrane|proteolysis|metallopeptidase activity|zinc ion binding|external side of plasma membrane|cell differentiation|secretory granule membrane|signaling receptor activity|peptide binding|peptide catabolic process|viral entry into host cell|metalloaminopeptidase activity|extracellular exosome","WP2406,WP100","Cardiac progenitor differentiation|Glutathione metabolism","R-HSA-168249,R-HSA-168256,R-HSA-2022377,R-HSA-2980736,R-HSA-392499,R-HSA-6798695","Innate Immune System|Immune System|Metabolism of Angiotensinogen to Angiotensins|Peptide hormone metabolism|Metabolism of proteins|Neutrophil degranulation"]
["ANTKMT",16.1737291411458,11.0516521810657,17.3370643428842,14.8280885789717,10.960061302275,15.0715730864706,18.5010798214499,17.0448440549899,12.9026661480293,14.5329142502813,18.6779752324931,15.1810731146151,13.6425992364009,13.76545308397,12.9956061486778,12.8086710594897,17.0097408971229,17.0864544781303,19.8735347786179,14.8081254220978,16.2306688051763,17.1408205659806,14.4376221479804,16.8910347307843,15.8199817502472,17.487669285408,17.3300573336523,21.5261027232933,65990,"adenine nucleotide translocase lysine methyltransferase","protein_coding",null,null,"GO:0005515,GO:0005739,GO:0006338,GO:0016279,GO:0018023,GO:0031966,GO:0042054,GO:1905273,GO:1905706","protein binding|mitochondrion|chromatin remodeling|protein-lysine N-methyltransferase activity|peptidyl-lysine trimethylation|mitochondrial membrane|histone methyltransferase activity|positive regulation of proton-transporting ATP synthase activity, rotational mechanism|regulation of mitochondrial ATP synthesis coupled proton transport"]
["ANTXR1",26.1253963067295,26.4451937111383,18.7371103696638,20.2684221602105,31.533157634576,24.8805363018571,18.9572044696268,22.0346993648635,27.8997568403987,23.1922506083261,20.3766756583506,23.8726205680065,29.7432173846256,23.2647662015503,25.7298988509976,27.6161874991698,15.6155347956059,15.0699993593937,11.2850328420496,17.5437850674808,16.8639373237017,14.7220954657792,14.1742417974664,15.7303233549209,17.8916960695897,13.3124208402195,12.9535535012196,12.6720476586792,84168,"ANTXR cell adhesion molecule 1","protein_coding","hsa04621","NOD-like receptor signaling pathway","GO:0001568,GO:0004888,GO:0005515,GO:0005518,GO:0005886,GO:0009897,GO:0009986,GO:0010008,GO:0022414,GO:0030036,GO:0031258,GO:0031527,GO:0034446,GO:0046872,GO:0051015,GO:1901202","blood vessel development|transmembrane signaling receptor activity|protein binding|collagen binding|plasma membrane|external side of plasma membrane|cell surface|endosome membrane|reproductive process|actin cytoskeleton organization|lamellipodium membrane|filopodium membrane|substrate adhesion-dependent cell spreading|metal ion binding|actin filament binding|negative regulation of extracellular matrix assembly","WP5316","Primary ovarian insufficiency","R-HSA-1643685,R-HSA-5210891,R-HSA-5339562,R-HSA-5663205,R-HSA-9824439","Disease|Uptake and function of anthrax toxins|Uptake and actions of bacterial toxins|Infectious disease|Bacterial Infection Pathways"]
["ANTXR2",17.1751849866941,14.5697892910113,11.4670045037558,13.0395753485358,16.1991158656643,14.2184684939906,11.1726687555021,12.4989775189339,14.9979462740764,10.8065058631255,11.6040961620627,14.3455353411763,16.0907064731399,14.526001789699,15.568770284438,15.5766545603141,12.5524147261046,11.8565108266179,10.34737560942,11.9150369897228,12.0639314776951,11.9609557635682,10.97495484286,12.3174829664937,13.7542173366451,11.1075908268581,10.5186252324932,10.3976839127276,118429,"ANTXR cell adhesion molecule 2","protein_coding","hsa04621","NOD-like receptor signaling pathway","GO:0004888,GO:0005515,GO:0005576,GO:0005789,GO:0005886,GO:0009986,GO:0010008,GO:0046872","transmembrane signaling receptor activity|protein binding|extracellular region|endoplasmic reticulum membrane|plasma membrane|cell surface|endosome membrane|metal ion binding",null,null,"R-HSA-1643685,R-HSA-5210891,R-HSA-5339562,R-HSA-5663205,R-HSA-9824439","Disease|Uptake and function of anthrax toxins|Uptake and actions of bacterial toxins|Infectious disease|Bacterial Infection Pathways"]
["ANTXRL",0,5.0501936301108E-3,0,0,0,0,0,0.00520645669096668,5.34061422631833E-3,0,0,0,5.04926564414232E-3,0,0,0.0151025724328226,0,0.0294760329766695,0,0.00510570577977423,0.00501135907404471,0,0,0,0,0.00504495824183168,0.0051378834734969,0,195977,"ANTXR like","protein_coding",null,null,"GO:0004888,GO:0005886,GO:0009986,GO:0046872","transmembrane signaling receptor activity|plasma membrane|cell surface|metal ion binding"]
["ANXA1",403.564709677087,305.533630418012,311.013757083896,318.397379906607,315.768772573614,287.325298705512,312.043440967549,302.152566437712,328.079748115124,262.559672749358,277.866926381373,307.215318213513,321.395325119402,249.139323165848,250.646042641094,253.294514026628,528.221782398512,400.191710242797,537.619134099889,403.688651719145,551.472168930057,437.37725334801,667.694749416903,575.546004336496,541.061008448257,486.960028939496,708.298145132021,511.047637488045,301,"annexin A1","protein_coding",null,null,"GO:0001533,GO:0001780,GO:0001891,GO:0002250,GO:0002548,GO:0002685,GO:0005102,GO:0005509,GO:0005515,GO:0005543,GO:0005544,GO:0005576,GO:0005615,GO:0005634,GO:0005654,GO:0005737,GO:0005768,GO:0005829,GO:0005884,GO:0005886,GO:0005912,GO:0005925,GO:0006909,GO:0006954,GO:0007165,GO:0007166,GO:0007187,GO:0008289,GO:0008360,GO:0009986,GO:0010165,GO:0014839,GO:0016323,GO:0016324,GO:0016328,GO:0018149,GO:0019834,GO:0030036,GO:0030073,GO:0030216,GO:0030850,GO:0031018,GO:0031340,GO:0031394,GO:0031514,GO:0031901,GO:0031982,GO:0032355,GO:0032508,GO:0032652,GO:0032717,GO:0032743,GO:0033031,GO:0035924,GO:0042063,GO:0042102,GO:0042119,GO:0042383,GO:0043066,GO:0043434,GO:0044849,GO:0045087,GO:0045627,GO:0045629,GO:0045920,GO:0046632,GO:0046883,GO:0048306,GO:0050482,GO:0050727,GO:0051179,GO:0062023,GO:0070062,GO:0070301,GO:0070365,GO:0070459,GO:0070555,GO:0071385,GO:0071621,GO:0090050,GO:0090303,GO:0097350,GO:0098609,GO:0098641,GO:1900087,GO:1900138","cornified envelope|neutrophil homeostasis|phagocytic cup|adaptive immune response|monocyte chemotaxis|regulation of leukocyte migration|signaling receptor binding|calcium ion binding|protein binding|phospholipid binding|calcium-dependent phospholipid binding|extracellular region|extracellular space|nucleus|nucleoplasm|cytoplasm|endosome|cytosol|actin filament|plasma membrane|adherens junction|focal adhesion|phagocytosis|inflammatory response|signal transduction|cell surface receptor signaling pathway|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|lipid binding|regulation of cell shape|cell surface|response to X-ray|myoblast migration involved in skeletal muscle regeneration|basolateral plasma membrane|apical plasma membrane|lateral plasma membrane|peptide cross-linking|phospholipase A2 inhibitor activity|actin cytoskeleton organization|insulin secretion|keratinocyte differentiation|prostate gland development|endocrine pancreas development|positive regulation of vesicle fusion|positive regulation of prostaglandin biosynthetic process|motile cilium|early endosome membrane|vesicle|response to estradiol|DNA duplex unwinding|regulation of interleukin-1 production|negative regulation of interleukin-8 production|positive regulation of interleukin-2 production|positive regulation of neutrophil apoptotic process|cellular response to vascular endothelial growth factor stimulus|gliogenesis|positive regulation of T cell proliferation|neutrophil activation|sarcolemma|negative regulation of apoptotic process|response to peptide hormone|estrous cycle|innate immune response|positive regulation of T-helper 1 cell differentiation|negative regulation of T-helper 2 cell differentiation|negative regulation of exocytosis|alpha-beta T cell differentiation|regulation of hormone secretion|calcium-dependent protein binding|arachidonic acid secretion|regulation of inflammatory response|localization|collagen-containing extracellular matrix|extracellular exosome|cellular response to hydrogen peroxide|hepatocyte differentiation|prolactin secretion|response to interleukin-1|cellular response to glucocorticoid stimulus|granulocyte chemotaxis|positive regulation of cell migration involved in sprouting angiogenesis|positive regulation of wound healing|neutrophil clearance|cell-cell adhesion|cadherin binding involved in cell-cell adhesion|positive regulation of G1/S transition of mitotic cell cycle|negative regulation of phospholipase A2 activity","WP98,WP2431,WP3888","Prostaglandin synthesis and regulation|Spinal cord injury|VEGFA-VEGFR2 signaling","R-HSA-1280215,R-HSA-162582,R-HSA-168256,R-HSA-372790,R-HSA-373076,R-HSA-375276,R-HSA-388396,R-HSA-397014,R-HSA-416476,R-HSA-418594,R-HSA-444473,R-HSA-445355,R-HSA-449147,R-HSA-500792,R-HSA-6785807","Cytokine Signaling in Immune system|Signal Transduction|Immune System|Signaling by GPCR|Class A/1 (Rhodopsin-like receptors)|Peptide ligand-binding receptors|GPCR downstream signalling|Muscle contraction|G alpha (q) signalling events|G alpha (i) signalling events|Formyl peptide receptors bind formyl peptides and many other ligands|Smooth Muscle Contraction|Signaling by Interleukins|GPCR ligand binding|Interleukin-4 and Interleukin-13 signaling"]
["ANXA10",0.0712656053806824,0,0.0167266752776932,0,0,0.0167305088017484,0,0.0174707076140369,0,0,0,0,0,0,0,0,0,0,0,0,0.0168160409906973,0,0,0,0.017663593994719,0,0,0,11199,"annexin A10","protein_coding",null,null,"GO:0005509,GO:0005515,GO:0005544,GO:0005737","calcium ion binding|protein binding|calcium-dependent phospholipid binding|cytoplasm","WP5390","Pancreatic cancer subtypes"]
["ANXA11",26.2827568400225,33.7631761454326,42.5940828939483,37.384212871981,27.2810022184596,37.7488254401881,43.8413506492624,37.6744414917253,25.8074407977699,33.3353971203548,34.3353455914527,28.4453221043114,25.470757640691,33.7166797371573,32.4324586676326,30.3504685869834,23.3411352691823,27.0122942162785,28.9978262695024,25.5892656884976,24.3879495615851,27.1864210528557,22.9962199623215,22.3382899302605,23.3127475990771,27.8246116703372,23.6195574540111,28.3703340320946,311,"annexin A11","protein_coding","hsa05014","Amyotrophic lateral sclerosis","GO:0003723,GO:0005509,GO:0005515,GO:0005544,GO:0005635,GO:0005654,GO:0005737,GO:0005819,GO:0005829,GO:0006909,GO:0008429,GO:0016020,GO:0023026,GO:0030496,GO:0032506,GO:0042470,GO:0042581,GO:0042582,GO:0044548,GO:0045335,GO:0048306,GO:0051592,GO:0062023,GO:0070062","RNA binding|calcium ion binding|protein binding|calcium-dependent phospholipid binding|nuclear envelope|nucleoplasm|cytoplasm|spindle|cytosol|phagocytosis|phosphatidylethanolamine binding|membrane|MHC class II protein complex binding|midbody|cytokinetic process|melanosome|specific granule|azurophil granule|S100 protein binding|phagocytic vesicle|calcium-dependent protein binding|response to calcium ion|collagen-containing extracellular matrix|extracellular exosome"]
["ANXA13",0,0,0,0,0,0,0.01592774248403,0,0,0,0.0160549474452313,0.0343510984383462,0,0,0,0.0161865653876801,0.0820670300568036,0.0157958432998259,0,0,0.0161131539068556,0,0.01685352678259,0.016678584077058,0,0,0.0165199711177604,0,312,"annexin A13","protein_coding",null,null,"GO:0001786,GO:0005509,GO:0005544,GO:0005615,GO:0005654,GO:0005737,GO:0005886,GO:0016020,GO:0016324,GO:0030154,GO:0031410,GO:0070062,GO:1901611","phosphatidylserine binding|calcium ion binding|calcium-dependent phospholipid binding|extracellular space|nucleoplasm|cytoplasm|plasma membrane|membrane|apical plasma membrane|cell differentiation|cytoplasmic vesicle|extracellular exosome|phosphatidylglycerol binding"]
["ANXA2",452.727228985068,451.788854850765,504.769922932145,506.221583838744,453.795529818035,486.07611710969,535.397833835075,524.437114474043,467.94562659405,465.644967423499,504.199023879204,491.042340926963,478.83544879388,490.388081648565,481.007374159585,473.97928332057,794.536452246611,663.07051904923,858.456314386066,634.426184950357,788.452206682182,689.725395644473,888.05114753431,826.982215688869,763.352984131234,772.01146124794,965.493016328766,844.441695353363,302,"annexin A2","protein_coding","hsa05132","Salmonella infection","GO:0001525,GO:0001533,GO:0001765,GO:0001786,GO:0001921,GO:0002020,GO:0002091,GO:0003723,GO:0004867,GO:0005262,GO:0005509,GO:0005515,GO:0005544,GO:0005546,GO:0005576,GO:0005604,GO:0005615,GO:0005634,GO:0005737,GO:0005765,GO:0005768,GO:0005769,GO:0005811,GO:0005829,GO:0005886,GO:0005912,GO:0006900,GO:0008092,GO:0009986,GO:0010756,GO:0016020,GO:0016323,GO:0016363,GO:0019834,GO:0030199,GO:0030496,GO:0031340,GO:0031902,GO:0031982,GO:0032804,GO:0035578,GO:0035749,GO:0036035,GO:0042383,GO:0042470,GO:0042730,GO:0042789,GO:0042802,GO:0043220,GO:0044090,GO:0044548,GO:0045121,GO:0045921,GO:0045944,GO:0046790,GO:0048306,GO:0050767,GO:0062023,GO:0070062,GO:0070588,GO:0090575,GO:0098609,GO:0098641,GO:0098797,GO:1905581,GO:1905597,GO:1905599,GO:1905602,GO:1905686,GO:1990665,GO:1990667","angiogenesis|cornified envelope|membrane raft assembly|phosphatidylserine binding|positive regulation of receptor recycling|protease binding|negative regulation of receptor internalization|RNA binding|serine-type endopeptidase inhibitor activity|calcium channel activity|calcium ion binding|protein binding|calcium-dependent phospholipid binding|phosphatidylinositol-4,5-bisphosphate binding|extracellular region|basement membrane|extracellular space|nucleus|cytoplasm|lysosomal membrane|endosome|early endosome|lipid droplet|cytosol|plasma membrane|adherens junction|vesicle budding from membrane|cytoskeletal protein binding|cell surface|positive regulation of plasminogen activation|membrane|basolateral plasma membrane|nuclear matrix|phospholipase A2 inhibitor activity|collagen fibril organization|midbody|positive regulation of vesicle fusion|late endosome membrane|vesicle|negative regulation of low-density lipoprotein particle receptor catabolic process|azurophil granule lumen|myelin sheath adaxonal region|osteoclast development|sarcolemma|melanosome|fibrinolysis|mRNA transcription by RNA polymerase II|identical protein binding|Schmidt-Lanterman incisure|positive regulation of vacuole organization|S100 protein binding|membrane raft|positive regulation of exocytosis|positive regulation of transcription by RNA polymerase II|virion binding|calcium-dependent protein binding|regulation of neurogenesis|collagen-containing extracellular matrix|extracellular exosome|calcium ion transmembrane transport|RNA polymerase II transcription regulator complex|cell-cell adhesion|cadherin binding involved in cell-cell adhesion|plasma membrane protein complex|positive regulation of low-density lipoprotein particle clearance|positive regulation of low-density lipoprotein particle receptor binding|positive regulation of low-density lipoprotein receptor activity|positive regulation of receptor-mediated endocytosis involved in cholesterol transport|positive regulation of plasma membrane repair|AnxA2-p11 complex|PCSK9-AnxA2 complex","WP98,WP4659,WP4522","Prostaglandin synthesis and regulation|Gastrin signaling pathway|Metabolic pathway of LDL, HDL and TG, including diseases","R-HSA-109582,R-HSA-1280215,R-HSA-168249,R-HSA-168256,R-HSA-397014,R-HSA-445355,R-HSA-447115,R-HSA-449147,R-HSA-6798695,R-HSA-75205,R-HSA-8950505,R-HSA-9020591","Hemostasis|Cytokine Signaling in Immune system|Innate Immune System|Immune System|Muscle contraction|Smooth Muscle Contraction|Interleukin-12 family signaling|Signaling by Interleukins|Neutrophil degranulation|Dissolution of Fibrin Clot|Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation|Interleukin-12 signaling"]
["ANXA2R",0.334936866705735,0.21238702028592,0.326097041631015,0.309326765501864,0.351529629908495,0.232979841850394,0.439805064209282,0.267616186673185,0.311945448999289,0.32258713267373,0.489982514805731,0.212169014123453,0.41289887650063,0.307494582122183,0.334562702233663,0.435189926205446,0.286241341098263,0.309905286424979,0.343950883797834,0.345940349320524,0.0702512747876438,0.200455082266154,0.134711876063877,0.169671780767346,0.0614933679567645,0.377185501979265,0.528182932985516,0.478150212404963,389289,"annexin A2 receptor","protein_coding",null,null,"GO:0005515,GO:0038023","protein binding|signaling receptor activity"]
["ANXA3",10.6544817200751,8.61226236165844,6.62730264363212,10.0016263438788,9.06833523634757,9.49247243139201,9.51902843379723,8.28805733128281,9.75130145943741,9.50016769587236,7.57690373104519,9.69660503850703,10.5261533136051,9.36809597842408,8.63064300503753,11.2800466649419,16.541847790525,15.0137505053816,15.2751822042035,14.5537858017504,17.0387713325063,15.5132916075293,18.5092680967533,19.2734549595272,17.4123195022145,14.201761785657,19.6548548269164,14.8300024677053,306,"annexin A3","protein_coding",null,null,"GO:0005509,GO:0005544,GO:0005737,GO:0005886,GO:0006909,GO:0010595,GO:0016020,GO:0019834,GO:0021766,GO:0030424,GO:0030425,GO:0030670,GO:0031100,GO:0042581,GO:0042742,GO:0043025,GO:0043312,GO:0045766,GO:0048306,GO:0051054,GO:0051091,GO:0051384,GO:0070062,GO:0070848","calcium ion binding|calcium-dependent phospholipid binding|cytoplasm|plasma membrane|phagocytosis|positive regulation of endothelial cell migration|membrane|phospholipase A2 inhibitor activity|hippocampus development|axon|dendrite|phagocytic vesicle membrane|animal organ regeneration|specific granule|defense response to bacterium|neuronal cell body|neutrophil degranulation|positive regulation of angiogenesis|calcium-dependent protein binding|positive regulation of DNA metabolic process|positive regulation of DNA-binding transcription factor activity|response to glucocorticoid|extracellular exosome|response to growth factor","WP98","Prostaglandin synthesis and regulation"]
["ANXA4",14.4242379127635,15.1065570992861,14.9426418880988,13.0440154138747,15.0727918596681,16.4392544839575,16.3860249443208,15.666576155634,13.8287860829965,12.7901657350523,11.7358718930827,12.9692049932569,14.32434709838,13.6941309082493,13.7692289702458,14.6576006103506,12.5462286335502,10.7461864164295,10.0638428603541,11.8330944568685,11.5752206181097,10.0883118749666,10.3583234969613,11.8817793624369,12.413259593939,11.6061734877235,11.2278584364953,10.602647655147,307,"annexin A4","protein_coding",null,null,"GO:0004859,GO:0005509,GO:0005515,GO:0005544,GO:0005634,GO:0005737,GO:0005886,GO:0006357,GO:0007165,GO:0007219,GO:0009986,GO:0012506,GO:0030855,GO:0031410,GO:0031965,GO:0032088,GO:0032717,GO:0042802,GO:0043066,GO:0048306,GO:0048471,GO:0051059,GO:0062023,GO:0070062","phospholipase inhibitor activity|calcium ion binding|protein binding|calcium-dependent phospholipid binding|nucleus|cytoplasm|plasma membrane|regulation of transcription by RNA polymerase II|signal transduction|Notch signaling pathway|cell surface|vesicle membrane|epithelial cell differentiation|cytoplasmic vesicle|nuclear membrane|negative regulation of NF-kappaB transcription factor activity|negative regulation of interleukin-8 production|identical protein binding|negative regulation of apoptotic process|calcium-dependent protein binding|perinuclear region of cytoplasm|NF-kappaB binding|collagen-containing extracellular matrix|extracellular exosome","WP98","Prostaglandin synthesis and regulation"]
["ANXA5",430.783634057895,361.901386498888,333.645877932728,360.293734128721,379.845228637934,348.079119206374,334.947075125704,357.955643413715,351.987798294253,302.94306643786,301.114275044479,357.91803620582,315.793697514952,273.075108316531,271.001797754431,266.521382199104,361.72389296326,325.87350651141,322.140347928774,334.223851820014,335.817928160239,342.089420496234,316.509374874319,353.07488883079,362.234960726018,347.940309325371,332.397011193434,345.467279736736,308,"annexin A5","protein_coding",null,null,"GO:0001786,GO:0004859,GO:0005509,GO:0005515,GO:0005543,GO:0005544,GO:0005576,GO:0005737,GO:0005829,GO:0005925,GO:0007165,GO:0007596,GO:0009897,GO:0010033,GO:0016020,GO:0042383,GO:0043066,GO:0050819,GO:0062023,GO:0070062,GO:0072563","phosphatidylserine binding|phospholipase inhibitor activity|calcium ion binding|protein binding|phospholipid binding|calcium-dependent phospholipid binding|extracellular region|cytoplasm|cytosol|focal adhesion|signal transduction|blood coagulation|external side of plasma membrane|response to organic substance|membrane|sarcolemma|negative regulation of apoptotic process|negative regulation of coagulation|collagen-containing extracellular matrix|extracellular exosome|endothelial microparticle","WP98,WP2864,WP5413,WP3670","Prostaglandin synthesis and regulation|Apoptosis-related network due to altered Notch3 in ovarian cancer|IL-24 Signaling pathway|Interactions between LOXL4 and oxidative stress pathway","R-HSA-109582,R-HSA-114608,R-HSA-76002,R-HSA-76005","Hemostasis|Platelet degranulation |Platelet activation, signaling and aggregation|Response to elevated platelet cytosolic Ca2+"]
["ANXA6",188.861927590295,189.217077781699,193.105654313139,208.376379769392,194.578269063178,207.367289892217,205.549407553855,212.725823516667,196.888503079715,217.934687807513,206.832540736429,199.927809642345,199.500424060473,212.635280345873,193.092475308855,201.266516551768,253.270146055978,243.699719637304,245.858074838164,232.01640510723,252.318330296198,238.576697428045,223.228653274154,246.025903412126,241.360041597358,254.3216620017,240.992779127243,257.8529974444,309,"annexin A6","protein_coding",null,null,"GO:0001755,GO:0001778,GO:0001786,GO:0003418,GO:0005262,GO:0005509,GO:0005515,GO:0005525,GO:0005544,GO:0005737,GO:0005739,GO:0005765,GO:0005925,GO:0006937,GO:0008289,GO:0015276,GO:0015485,GO:0016020,GO:0031902,GO:0034220,GO:0035374,GO:0042383,GO:0042470,GO:0042802,GO:0048306,GO:0048471,GO:0051015,GO:0051283,GO:0051560,GO:0062023,GO:0070062,GO:0070588,GO:0097190","neural crest cell migration|plasma membrane repair|phosphatidylserine binding|growth plate cartilage chondrocyte differentiation|calcium channel activity|calcium ion binding|protein binding|GTP binding|calcium-dependent phospholipid binding|cytoplasm|mitochondrion|lysosomal membrane|focal adhesion|regulation of muscle contraction|lipid binding|ligand-gated monoatomic ion channel activity|cholesterol binding|membrane|late endosome membrane|monoatomic ion transmembrane transport|chondroitin sulfate binding|sarcolemma|melanosome|identical protein binding|calcium-dependent protein binding|perinuclear region of cytoplasm|actin filament binding|negative regulation of sequestering of calcium ion|mitochondrial calcium ion homeostasis|collagen-containing extracellular matrix|extracellular exosome|calcium ion transmembrane transport|apoptotic signaling pathway","WP98,WP536","Prostaglandin synthesis and regulation|Calcium regulation in cardiac cells","R-HSA-397014,R-HSA-445355","Muscle contraction|Smooth Muscle Contraction"]
["ANXA7",23.809661545638,22.6100541842933,24.8289791583735,23.2120671805299,23.5960022971758,22.6498013241708,26.3541651344561,25.2109312078905,23.3976446968864,20.4774497209166,21.1100056902824,22.1097004778327,24.2706546564233,22.3615856327474,24.9609395468622,24.19819341227,25.8368766983136,23.7217209305236,27.6629036612688,24.30222986616,24.9041178175379,24.0379016468928,26.9179777811243,25.5507236293632,23.759232764243,25.0500351412652,26.3584287135098,25.1805143197356,310,"annexin A7","protein_coding","hsa05014","Amyotrophic lateral sclerosis","GO:0003723,GO:0005178,GO:0005509,GO:0005515,GO:0005544,GO:0005634,GO:0005737,GO:0005789,GO:0006914,GO:0010629,GO:0016020,GO:0030855,GO:0042584,GO:0048306,GO:0062023,GO:0070062","RNA binding|integrin binding|calcium ion binding|protein binding|calcium-dependent phospholipid binding|nucleus|cytoplasm|endoplasmic reticulum membrane|autophagy|negative regulation of gene expression|membrane|epithelial cell differentiation|chromaffin granule membrane|calcium-dependent protein binding|collagen-containing extracellular matrix|extracellular exosome"]
["ANXA8",0,0.00647470531820013,0.00639077265029037,0.00652842911262191,0,0.0191767119826101,0.0317549310382367,0,0,0.00655613392536492,0,0.00684853338815009,0,0,0,0,0.0196339152211656,0,0.031456450778312,0.00654587581917014,0.0256996666857828,0.019411269775595,0,0,0.0202462255409165,0.00646799318024733,0.00658712989771308,0.019198455498078,653145,"annexin A8","protein_coding",null,null,"GO:0005509,GO:0005515,GO:0005544,GO:0005546,GO:0005547,GO:0005737,GO:0005829,GO:0005886,GO:0007032,GO:0007596,GO:0016197,GO:0031902,GO:0042383,GO:0043325,GO:0051015,GO:0062023,GO:1900004,GO:1900138","calcium ion binding|protein binding|calcium-dependent phospholipid binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylinositol-3,4,5-trisphosphate binding|cytoplasm|cytosol|plasma membrane|endosome organization|blood coagulation|endosomal transport|late endosome membrane|sarcolemma|phosphatidylinositol-3,4-bisphosphate binding|actin filament binding|collagen-containing extracellular matrix|negative regulation of serine-type endopeptidase activity|negative regulation of phospholipase A2 activity"]
["ANXA8L1",0.0133314615406741,0.139484749584964,0,0,0.0260538860735755,0.0375567653071889,0.0124381332256594,0.0392183688724596,0.0670482156949015,0.115559155835808,0.0376124065519589,0.201188369562866,0.0633905085937452,0.0381297493124574,0.0123981846576238,0.0884817543175214,0.0897217490818843,0.197362109360436,0.123212210763714,0.192297242165532,0.125829228580242,0.0887043188558349,0.0526443497323633,0.117220256339797,0.105736964249297,0.0506691453882877,0.154807325786016,0.13786427983783,728113,"annexin A8 like 1","protein_coding",null,null,"GO:0005509,GO:0005544,GO:0005737,GO:0007032,GO:0016197,GO:0042383,GO:1900004,GO:1900138","calcium ion binding|calcium-dependent phospholipid binding|cytoplasm|endosome organization|endosomal transport|sarcolemma|negative regulation of serine-type endopeptidase activity|negative regulation of phospholipase A2 activity","WP5390","Pancreatic cancer subtypes"]
["ANXA9",0.556497897605724,0.0258205770997709,0.140172233961051,0.117156703712912,0.132630809770316,0.229425315562344,0.0759815872576539,0.27950493102759,0.191138055376764,0.130726537484617,0.0638236707351972,0.204835288648597,0.219434576274058,0.18116430740803,0.138852176815141,0.373211991776062,0.130497321711674,0.0502349175637969,0.0752673988411575,0.143574194704456,0.0640550604706068,0.0387052509120626,0.107197255950492,0.106084528731821,0.188393881166232,0.0644845241535233,0.144479042469477,0.0638015137398364,8416,"annexin A9","protein_coding",null,null,"GO:0001786,GO:0002020,GO:0005262,GO:0005509,GO:0005515,GO:0005543,GO:0005544,GO:0005546,GO:0005615,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0007271,GO:0009986,GO:0015464,GO:0019834,GO:0031982,GO:0045202,GO:0046790,GO:0062023,GO:0070588,GO:0098609","phosphatidylserine binding|protease binding|calcium channel activity|calcium ion binding|protein binding|phospholipid binding|calcium-dependent phospholipid binding|phosphatidylinositol-4,5-bisphosphate binding|extracellular space|nucleus|cytoplasm|cytosol|plasma membrane|synaptic transmission, cholinergic|cell surface|acetylcholine receptor activity|phospholipase A2 inhibitor activity|vesicle|synapse|virion binding|collagen-containing extracellular matrix|calcium ion transmembrane transport|cell-cell adhesion"]
["AOC2",0.140973856291895,0.172400819978074,0.21743428202781,0.260746970758885,0.22630967981653,0.0945583108593402,0.0751584770482882,0.138238523974796,0.172186430055774,0.213362117137763,0.113638081506254,0.233008748970007,0.191521267652675,0.211202063057571,0.187292711077441,0.0572848414205758,0.087131457910888,0.12112113388701,0.130291044538634,0.106514139216679,0.123554243648123,0.0478574450948551,0.178935725892706,0.0787014845205068,0.169714344840555,0.0956789428232329,0.126673682156992,0.217730709346899,314,"amine oxidase copper containing 2","protein_coding","hsa00260,hsa00350,hsa00360,hsa00410","Glycine, serine and threonine metabolism|Tyrosine metabolism|Phenylalanine metabolism|beta-Alanine metabolism","GO:0005507,GO:0005515,GO:0005737,GO:0005886,GO:0006584,GO:0006805,GO:0007601,GO:0008131,GO:0009055,GO:0009308,GO:0022900,GO:0048038,GO:0052593,GO:0052594,GO:0052596","copper ion binding|protein binding|cytoplasm|plasma membrane|catecholamine metabolic process|xenobiotic metabolic process|visual perception|primary amine oxidase activity|electron transfer activity|amine metabolic process|electron transport chain|quinone binding|tryptamine:oxygen oxidoreductase (deaminating) activity|aminoacetone:oxygen oxidoreductase(deaminating) activity|phenethylamine:oxygen oxidoreductase (deaminating) activity",null,null,"R-HSA-1430728,R-HSA-211859,R-HSA-211945","Metabolism|Biological oxidations|Phase I - Functionalization of compounds"]
["AOC3",0.0212756237057956,0.0708282681217473,0.0649165303940308,0.117326228014523,0.0155922329244582,0.044952513487255,0.0396999295695082,0.0156471077072047,0.0481508851308531,0.128069703751208,0.0650276058027357,0.0909714419278342,0.0252911618738265,0.0354964793323154,0.0593586330964061,0.0907763538770016,0.0613656703045112,0.0442925669166982,0.0147475388810713,0.0153443182185756,0.0251012924417176,0.0303348967290277,0.0525093109504926,0.0207857018608323,0.0316397210505247,0.0454852559084481,0.0360290530316903,0.0250019349422484,8639,"amine oxidase copper containing 3","protein_coding","hsa00260,hsa00350,hsa00360,hsa00410","Glycine, serine and threonine metabolism|Tyrosine metabolism|Phenylalanine metabolism|beta-Alanine metabolism","GO:0005507,GO:0005509,GO:0005515,GO:0005737,GO:0005769,GO:0005783,GO:0005794,GO:0005886,GO:0005902,GO:0006954,GO:0007155,GO:0008131,GO:0009308,GO:0009986,GO:0016020,GO:0042802,GO:0046677,GO:0046982,GO:0048038,GO:0052593,GO:1902283","copper ion binding|calcium ion binding|protein binding|cytoplasm|early endosome|endoplasmic reticulum|Golgi apparatus|plasma membrane|microvillus|inflammatory response|cell adhesion|primary amine oxidase activity|amine metabolic process|cell surface|membrane|identical protein binding|response to antibiotic|protein heterodimerization activity|quinone binding|tryptamine:oxygen oxidoreductase (deaminating) activity|negative regulation of primary amine oxidase activity","WP3925","Amino acid metabolism","R-HSA-1430728,R-HSA-211859,R-HSA-211945","Metabolism|Biological oxidations|Phase I - Functionalization of compounds"]
["AOPEP",1.35036935633204,1.26144084818855,1.3758695921588,1.48321062345229,1.326468955572,1.41355948883416,1.26386099078865,1.32834956395781,1.0923499260832,0.988439866520214,1.22182010560233,1.27134839068651,1.03411031858324,1.02721914605252,0.982195904220767,0.952853872085681,1.90781524237219,1.70056612980171,1.74200131595534,1.82752955294836,1.86889049442958,1.81592203561947,1.70638314956164,1.82615280525427,1.8531637995108,1.8152400349947,1.8362961884228,1.84812974156672,84909,"aminopeptidase O (putative)","protein_coding",null,null,"GO:0005730,GO:0005829,GO:0006508,GO:0008270,GO:0070006","nucleolus|cytosol|proteolysis|zinc ion binding|metalloaminopeptidase activity",null,null,"R-HSA-2022377,R-HSA-2980736,R-HSA-392499","Metabolism of Angiotensinogen to Angiotensins|Peptide hormone metabolism|Metabolism of proteins"]
["AOX1",8.63827720209935,7.35467492644537,6.07633231622007,5.94254768211696,8.374817102251,7.29522573827152,6.41257004145531,6.37214784891002,2.89107450873363,2.67295745674893,2.34067302369282,2.72930657622092,3.05026752018375,2.60618346420959,2.37762073101377,2.96710655496142,5.18135116383164,4.18183128126889,3.87874990674851,4.87689875788526,5.49447654648602,4.61281061014642,5.10953225361626,5.53467391778055,5.1416105163519,4.54676057587083,4.95298219243379,3.70069977026116,316,"aldehyde oxidase 1","protein_coding","hsa00280,hsa00350,hsa00380,hsa00750,hsa00760,hsa00830,hsa00982,hsa04630","Valine, leucine and isoleucine degradation|Tyrosine metabolism|Tryptophan metabolism|Vitamin B6 metabolism|Nicotinate and nicotinamide metabolism|Retinol metabolism|Drug metabolism - cytochrome P450|JAK-STAT signaling pathway","GO:0004031,GO:0005506,GO:0005829,GO:0006629,GO:0006805,GO:0042802,GO:0042803,GO:0043546,GO:0050660,GO:0051287,GO:0051537,GO:0070062,GO:0071949","aldehyde oxidase activity|iron ion binding|cytosol|lipid metabolic process|xenobiotic metabolic process|identical protein binding|protein homodimerization activity|molybdopterin cofactor binding|flavin adenine dinucleotide binding|NAD binding|2 iron, 2 sulfur cluster binding|extracellular exosome|FAD binding","WP5188,WP1600,WP4507,WP465,WP4224,WP1995","Retinol metabolism|Nicotine metabolism in liver cells|Molybdenum cofactor (Moco) biosynthesis|Tryptophan metabolism|Purine metabolism and related disorders|Effects of nitric oxide","R-HSA-1430728,R-HSA-196849,R-HSA-196854,R-HSA-964975","Metabolism|Metabolism of water-soluble vitamins and cofactors|Metabolism of vitamins and cofactors|Vitamins B6 activation to pyridoxal phosphate"]
["AP1AR",2.64721285355,2.07823270718271,1.8465724514662,1.33424571949983,2.4674223001137,1.99033235254555,1.79438736023087,1.5096121596624,2.1275577960045,1.36931024952096,1.2345218195797,1.47864500520208,2.65434037731738,1.72965080589291,2.14959368551839,1.99308183338049,1.7862066343902,1.23073922568834,1.7412450889977,2.08010798398013,2.11164693734161,1.80740559476629,3.35821722309877,2.20279006005788,1.91109170515974,1.51665597730517,2.47303513273532,1.3611925477233,55435,"adaptor related protein complex 1 associated regulatory protein","protein_coding",null,null,"GO:0001920,GO:0005768,GO:0005769,GO:0005770,GO:0005794,GO:0005829,GO:0015031,GO:0019894,GO:0030133,GO:0034315,GO:0034446,GO:0035650,GO:0048203,GO:1900025,GO:2000146","negative regulation of receptor recycling|endosome|early endosome|late endosome|Golgi apparatus|cytosol|protein transport|kinesin binding|transport vesicle|regulation of Arp2/3 complex-mediated actin nucleation|substrate adhesion-dependent cell spreading|AP-1 adaptor complex binding|vesicle targeting, trans-Golgi to endosome|negative regulation of substrate adhesion-dependent cell spreading|negative regulation of cell motility"]
["AP1B1",25.8753777936379,29.8074601865237,26.2675025839454,29.626497222568,25.8914574527384,30.2908251928341,27.0036919254673,26.3570225966427,23.9699512144732,33.9036968027459,27.5297710920672,25.0430394398242,22.7053934838465,24.8294336065459,23.425942746235,23.5764922647151,27.0243754677765,30.4150233232148,29.9021924545256,29.2513423160611,28.8207724247991,31.6333322750695,24.7076870491734,24.6156158979897,27.5784216410118,30.39152372035,22.5339624857161,31.9071416168394,162,"adaptor related protein complex 1 subunit beta 1","protein_coding","hsa04142,hsa05170","Lysosome|Human immunodeficiency virus 1 infection","GO:0000139,GO:0001822,GO:0005515,GO:0005765,GO:0005769,GO:0005794,GO:0005829,GO:0006886,GO:0007368,GO:0007507,GO:0016192,GO:0019901,GO:0030121,GO:0030276,GO:0030659,GO:0032588,GO:0043231,GO:0060155,GO:0110010,GO:1903232","Golgi membrane|kidney development|protein binding|lysosomal membrane|early endosome|Golgi apparatus|cytosol|intracellular protein transport|determination of left/right symmetry|heart development|vesicle-mediated transport|protein kinase binding|AP-1 adaptor complex|clathrin binding|cytoplasmic vesicle membrane|trans-Golgi network membrane|intracellular membrane-bounded organelle|platelet dense granule organization|basolateral protein secretion|melanosome assembly",null,null,"R-HSA-1280218,R-HSA-162906,R-HSA-162909,R-HSA-1643685,R-HSA-164938,R-HSA-164940,R-HSA-164952,R-HSA-168256,R-HSA-199991,R-HSA-199992,R-HSA-2132295,R-HSA-432720,R-HSA-432722,R-HSA-5653656,R-HSA-5663205,R-HSA-9824446","Adaptive Immune System|HIV Infection|Host Interactions of HIV factors|Disease|Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters|Nef mediated downregulation of MHC class I complex cell surface expression|The role of Nef in HIV-1 replication and disease pathogenesis|Immune System|Membrane Trafficking|trans-Golgi Network Vesicle Budding|MHC class II antigen presentation|Lysosome Vesicle Biogenesis|Golgi Associated Vesicle Biogenesis|Vesicle-mediated transport|Infectious disease|Viral Infection Pathways"]
["AP1G1",16.9990109386974,16.1611230315114,14.5122643630786,13.5500207572122,15.5986952929672,14.9635787876286,14.1746403652077,14.114222899521,16.4875933560147,13.0891413882976,14.4719067990411,15.0430713749828,15.964271053888,13.7457659757078,16.5067191319309,15.3135020580016,15.2693710056119,14.8646268472962,13.1482730234912,17.0288617733047,15.0362292790712,14.801658423893,16.5523200216739,16.8505669959103,15.943649956747,13.9747396080112,15.5460649699105,13.1980596898268,164,"adaptor related protein complex 1 subunit gamma 1","protein_coding","hsa04142,hsa05170","Lysosome|Human immunodeficiency virus 1 infection","GO:0000139,GO:0005515,GO:0005518,GO:0005737,GO:0005765,GO:0005769,GO:0005794,GO:0005829,GO:0005905,GO:0006886,GO:0006896,GO:0016020,GO:0016182,GO:0016192,GO:0019894,GO:0030121,GO:0030136,GO:0030659,GO:0030665,GO:0030742,GO:0031267,GO:0032438,GO:0032588,GO:0035615,GO:0035646,GO:0043231,GO:0043323,GO:0045954,GO:0048471,GO:0048488,GO:0055037,GO:0060155,GO:0090160,GO:0098793,GO:0110010,GO:1903232","Golgi membrane|protein binding|collagen binding|cytoplasm|lysosomal membrane|early endosome|Golgi apparatus|cytosol|clathrin-coated pit|intracellular protein transport|Golgi to vacuole transport|membrane|synaptic vesicle budding from endosome|vesicle-mediated transport|kinesin binding|AP-1 adaptor complex|clathrin-coated vesicle|cytoplasmic vesicle membrane|clathrin-coated vesicle membrane|GTP-dependent protein binding|small GTPase binding|melanosome organization|trans-Golgi network membrane|clathrin adaptor activity|endosome to melanosome transport|intracellular membrane-bounded organelle|positive regulation of natural killer cell degranulation|positive regulation of natural killer cell mediated cytotoxicity|perinuclear region of cytoplasm|synaptic vesicle endocytosis|recycling endosome|platelet dense granule organization|Golgi to lysosome transport|presynapse|basolateral protein secretion|melanosome assembly","WP5039","SARS-CoV-2 innate immunity evasion and cell-specific immune response","R-HSA-1280218,R-HSA-162906,R-HSA-162909,R-HSA-1643685,R-HSA-164938,R-HSA-164940,R-HSA-164952,R-HSA-168256,R-HSA-199991,R-HSA-199992,R-HSA-2132295,R-HSA-432720,R-HSA-432722,R-HSA-5653656,R-HSA-5663205,R-HSA-9824446","Adaptive Immune System|HIV Infection|Host Interactions of HIV factors|Disease|Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters|Nef mediated downregulation of MHC class I complex cell surface expression|The role of Nef in HIV-1 replication and disease pathogenesis|Immune System|Membrane Trafficking|trans-Golgi Network Vesicle Budding|MHC class II antigen presentation|Lysosome Vesicle Biogenesis|Golgi Associated Vesicle Biogenesis|Vesicle-mediated transport|Infectious disease|Viral Infection Pathways"]
["AP1G2",1.90677164242449,2.27682107607033,2.36761174558162,2.84629081699639,2.29396069589965,2.40184762287614,2.03246050341708,2.43774341143151,4.37726551902233,6.36345165506554,5.02773241732444,5.0176738975496,3.41216679458402,5.10177350869111,3.77061824258851,4.37397377304282,2.59216961710585,3.35780161472923,3.24979410254159,3.07077378131931,2.89308170209491,3.0402499883556,2.44914848720659,2.86440330773718,2.74415469967015,3.38003376643524,3.07028642146229,3.20930713015219,8906,"adaptor related protein complex 1 subunit gamma 2","protein_coding","hsa04142,hsa05170","Lysosome|Human immunodeficiency virus 1 infection","GO:0000139,GO:0005515,GO:0005794,GO:0005798,GO:0006886,GO:0006896,GO:0010008,GO:0016020,GO:0016192,GO:0030121,GO:0030133,GO:0035615","Golgi membrane|protein binding|Golgi apparatus|Golgi-associated vesicle|intracellular protein transport|Golgi to vacuole transport|endosome membrane|membrane|vesicle-mediated transport|AP-1 adaptor complex|transport vesicle|clathrin adaptor activity",null,null,"R-HSA-199991,R-HSA-199992,R-HSA-432720,R-HSA-5653656","Membrane Trafficking|trans-Golgi Network Vesicle Budding|Lysosome Vesicle Biogenesis|Vesicle-mediated transport"]
["AP1G2-AS1",3.44634298294081,4.52607034609413,4.17892741731372,4.83441639759443,4.83639105882605,3.72758416283046,3.27739062745098,4.15308752810206,4.39375261016992,4.85493229792919,3.80339528706158,4.82081050808746,3.4906727604705,5.84294358133336,4.41760382133495,4.369998658246,2.32340712099634,2.77385422117174,1.64248026171119,2.07628889199555,2.22603767263546,2.26548534867111,1.7216453930496,2.25547277376264,3.0792226201601,2.5565908718375,1.98490557472308,2.72469022762002,102724814,"AP1G2 antisense RNA 1","non_coding"]
["AP1M1",7.1555738464705,7.96733703541765,7.10846211832748,7.98532945297165,6.83279578551278,7.94437863354654,6.99594498691359,7.51075407458849,6.47841438182575,8.47624989143961,7.79100968355864,7.16965764001601,5.54450208239171,6.95549314600397,6.00142709492111,5.89462869220743,7.62127837182095,8.14882627927114,7.76289098317085,7.63679082269317,7.31217798294968,8.29589047951177,5.9930540027388,6.63135458586036,6.61959725308627,8.57880106088666,6.36802545756363,8.53117129264421,8907,"adaptor related protein complex 1 subunit mu 1","protein_coding","hsa04142,hsa05170","Lysosome|Human immunodeficiency virus 1 infection","GO:0000139,GO:0005515,GO:0005765,GO:0005769,GO:0005829,GO:0005886,GO:0006886,GO:0016020,GO:0016192,GO:0030121,GO:0030136,GO:0030659,GO:0032438,GO:0032588,GO:0035579,GO:0035615,GO:0035646,GO:0043231,GO:0060155,GO:0070062,GO:1903232","Golgi membrane|protein binding|lysosomal membrane|early endosome|cytosol|plasma membrane|intracellular protein transport|membrane|vesicle-mediated transport|AP-1 adaptor complex|clathrin-coated vesicle|cytoplasmic vesicle membrane|melanosome organization|trans-Golgi network membrane|specific granule membrane|clathrin adaptor activity|endosome to melanosome transport|intracellular membrane-bounded organelle|platelet dense granule organization|extracellular exosome|melanosome assembly",null,null,"R-HSA-1280218,R-HSA-162906,R-HSA-162909,R-HSA-1643685,R-HSA-164938,R-HSA-164940,R-HSA-164952,R-HSA-168249,R-HSA-168256,R-HSA-199991,R-HSA-199992,R-HSA-2132295,R-HSA-432720,R-HSA-432722,R-HSA-5653656,R-HSA-5663205,R-HSA-6798695,R-HSA-9824446","Adaptive Immune System|HIV Infection|Host Interactions of HIV factors|Disease|Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters|Nef mediated downregulation of MHC class I complex cell surface expression|The role of Nef in HIV-1 replication and disease pathogenesis|Innate Immune System|Immune System|Membrane Trafficking|trans-Golgi Network Vesicle Budding|MHC class II antigen presentation|Lysosome Vesicle Biogenesis|Golgi Associated Vesicle Biogenesis|Vesicle-mediated transport|Infectious disease|Neutrophil degranulation|Viral Infection Pathways"]
["AP1M2",0.161980261804164,0.0770350517578544,0.0253454779120179,0.116511373847694,0.0527600977874508,0.0760538602414983,0.0125938434563262,0.105891559819881,0.0135775154867392,0.039001938424304,0.0253888452839462,0.0679023340437515,0,0,0,0.0511939644409552,0.0129778508222026,0.062447763070669,0.0249509354195524,0.116822741209426,0.0764426740678768,0.0384920522340292,0.0932809371697384,0.158250280967498,0.107060661848812,0.0769551917689918,0.0653105518150821,0.0634500782610492,10053,"adaptor related protein complex 1 subunit mu 2","protein_coding","hsa04142,hsa05170","Lysosome|Human immunodeficiency virus 1 infection","GO:0000139,GO:0005515,GO:0005765,GO:0005829,GO:0006605,GO:0006903,GO:0016192,GO:0030121,GO:0030136,GO:0030659,GO:0032588,GO:0035615,GO:0043231,GO:0110010","Golgi membrane|protein binding|lysosomal membrane|cytosol|protein targeting|vesicle targeting|vesicle-mediated transport|AP-1 adaptor complex|clathrin-coated vesicle|cytoplasmic vesicle membrane|trans-Golgi network membrane|clathrin adaptor activity|intracellular membrane-bounded organelle|basolateral protein secretion",null,null,"R-HSA-1280218,R-HSA-162906,R-HSA-162909,R-HSA-1643685,R-HSA-164938,R-HSA-164940,R-HSA-164952,R-HSA-168256,R-HSA-199991,R-HSA-199992,R-HSA-2132295,R-HSA-432720,R-HSA-432722,R-HSA-5653656,R-HSA-5663205,R-HSA-9824446","Adaptive Immune System|HIV Infection|Host Interactions of HIV factors|Disease|Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters|Nef mediated downregulation of MHC class I complex cell surface expression|The role of Nef in HIV-1 replication and disease pathogenesis|Immune System|Membrane Trafficking|trans-Golgi Network Vesicle Budding|MHC class II antigen presentation|Lysosome Vesicle Biogenesis|Golgi Associated Vesicle Biogenesis|Vesicle-mediated transport|Infectious disease|Viral Infection Pathways"]
["AP1S1",84.4965213287433,72.6531648048058,73.1356685969951,83.061427249173,68.7301727132228,71.8516673436524,77.6241777867541,83.5900825969711,69.245406504889,68.3574822445911,78.2234361391558,76.0073250064172,67.5378817383794,66.5125270302775,64.0837287681569,62.8332630146009,91.7867920515476,87.1533206098707,98.5770246644931,77.1518494470158,84.130982264863,84.7268676384553,93.6402568179506,89.7898239780422,84.2295827462758,90.3149206297786,102.574185006544,96.303586866656,1174,"adaptor related protein complex 1 subunit sigma 1","protein_coding","hsa04142,hsa05170","Lysosome|Human immunodeficiency virus 1 infection","GO:0000139,GO:0005765,GO:0005769,GO:0005794,GO:0005829,GO:0005905,GO:0006886,GO:0006898,GO:0009615,GO:0016020,GO:0016192,GO:0030121,GO:0030659,GO:0032588,GO:0035615,GO:0043231,GO:0060155,GO:0110010,GO:1903232","Golgi membrane|lysosomal membrane|early endosome|Golgi apparatus|cytosol|clathrin-coated pit|intracellular protein transport|receptor-mediated endocytosis|response to virus|membrane|vesicle-mediated transport|AP-1 adaptor complex|cytoplasmic vesicle membrane|trans-Golgi network membrane|clathrin adaptor activity|intracellular membrane-bounded organelle|platelet dense granule organization|basolateral protein secretion|melanosome assembly",null,null,"R-HSA-1280218,R-HSA-162906,R-HSA-162909,R-HSA-1643685,R-HSA-164938,R-HSA-164940,R-HSA-164952,R-HSA-168256,R-HSA-199991,R-HSA-199992,R-HSA-2132295,R-HSA-432720,R-HSA-432722,R-HSA-5653656,R-HSA-5663205,R-HSA-9824446","Adaptive Immune System|HIV Infection|Host Interactions of HIV factors|Disease|Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters|Nef mediated downregulation of MHC class I complex cell surface expression|The role of Nef in HIV-1 replication and disease pathogenesis|Immune System|Membrane Trafficking|trans-Golgi Network Vesicle Budding|MHC class II antigen presentation|Lysosome Vesicle Biogenesis|Golgi Associated Vesicle Biogenesis|Vesicle-mediated transport|Infectious disease|Viral Infection Pathways"]
["AP1S2",12.2782331818733,11.5640505560534,9.83977919859688,11.1008036190437,12.6711170013685,11.3126831502705,10.4618930683899,10.7783491230436,13.1596925687083,8.10799449977575,9.00917320126,9.8076776644872,14.8568223938785,10.0794772210032,14.6990962386319,13.3960987384044,10.878185820499,10.7720761448243,14.3495398732419,14.3046460259138,14.7316425082763,14.1168580893576,21.3359954901408,15.0084954975807,12.6124502618852,13.1225568609531,16.3999045346831,10.7592345345861,8905,"adaptor related protein complex 1 subunit sigma 2","protein_coding","hsa04142,hsa05170","Lysosome|Human immunodeficiency virus 1 infection","GO:0000139,GO:0005515,GO:0005765,GO:0005769,GO:0005794,GO:0005829,GO:0005905,GO:0006886,GO:0016192,GO:0030119,GO:0030121,GO:0030659,GO:0032588,GO:0035615,GO:0043231,GO:0060155,GO:1903232","Golgi membrane|protein binding|lysosomal membrane|early endosome|Golgi apparatus|cytosol|clathrin-coated pit|intracellular protein transport|vesicle-mediated transport|AP-type membrane coat adaptor complex|AP-1 adaptor complex|cytoplasmic vesicle membrane|trans-Golgi network membrane|clathrin adaptor activity|intracellular membrane-bounded organelle|platelet dense granule organization|melanosome assembly",null,null,"R-HSA-1280218,R-HSA-162906,R-HSA-162909,R-HSA-1643685,R-HSA-164938,R-HSA-164940,R-HSA-164952,R-HSA-168256,R-HSA-199991,R-HSA-199992,R-HSA-2132295,R-HSA-432720,R-HSA-432722,R-HSA-5653656,R-HSA-5663205,R-HSA-9824446","Adaptive Immune System|HIV Infection|Host Interactions of HIV factors|Disease|Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters|Nef mediated downregulation of MHC class I complex cell surface expression|The role of Nef in HIV-1 replication and disease pathogenesis|Immune System|Membrane Trafficking|trans-Golgi Network Vesicle Budding|MHC class II antigen presentation|Lysosome Vesicle Biogenesis|Golgi Associated Vesicle Biogenesis|Vesicle-mediated transport|Infectious disease|Viral Infection Pathways"]
["AP1S3",0.58835693062372,0.495300337587954,0.241265295638659,0.311320573438829,0.667433106086018,0.368331427342858,0.107262516683095,0.218839678991783,0.326514381459326,0.162834234473438,0.19715846023498,0.312977632209086,0.30870191681257,0.167633147755018,0.113207307776939,0.121829690967333,0.37061108410449,0.269064318245931,0.231259366183556,0.312152552861982,0.351065441806541,0.314982671622049,0.206965198816106,0.508738657260648,0.29500772188069,0.276309553119045,0.261766526793214,0.178016787558696,130340,"adaptor related protein complex 1 subunit sigma 3","protein_coding","hsa04142,hsa05170","Lysosome|Human immunodeficiency virus 1 infection","GO:0000139,GO:0005515,GO:0005765,GO:0005769,GO:0005829,GO:0005905,GO:0006605,GO:0016192,GO:0030121,GO:0030659,GO:0032588,GO:0035615,GO:0043231,GO:0060155,GO:1903232","Golgi membrane|protein binding|lysosomal membrane|early endosome|cytosol|clathrin-coated pit|protein targeting|vesicle-mediated transport|AP-1 adaptor complex|cytoplasmic vesicle membrane|trans-Golgi network membrane|clathrin adaptor activity|intracellular membrane-bounded organelle|platelet dense granule organization|melanosome assembly",null,null,"R-HSA-1280218,R-HSA-162906,R-HSA-162909,R-HSA-1643685,R-HSA-164938,R-HSA-164940,R-HSA-164952,R-HSA-168256,R-HSA-199991,R-HSA-199992,R-HSA-2132295,R-HSA-432720,R-HSA-432722,R-HSA-5653656,R-HSA-5663205,R-HSA-9824446","Adaptive Immune System|HIV Infection|Host Interactions of HIV factors|Disease|Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters|Nef mediated downregulation of MHC class I complex cell surface expression|The role of Nef in HIV-1 replication and disease pathogenesis|Immune System|Membrane Trafficking|trans-Golgi Network Vesicle Budding|MHC class II antigen presentation|Lysosome Vesicle Biogenesis|Golgi Associated Vesicle Biogenesis|Vesicle-mediated transport|Infectious disease|Viral Infection Pathways"]
["AP2A1",37.9175340260993,39.931765058067,36.9074458602197,41.8162921273852,37.9984777972566,42.018484632516,34.8224971530619,38.0892874070227,38.1147410038808,50.8465825511829,44.2271122993479,40.960234638221,36.9630981984993,39.4880917806574,33.5243634568615,36.3428756112295,36.4734474631852,40.6899860820692,36.6449920373785,39.294386911152,38.8692704116539,40.7968966774259,30.8031725262471,33.7211489451087,35.6829510465879,40.5973921842948,29.3101151958032,41.3254436650348,160,"adaptor related protein complex 2 subunit alpha 1","protein_coding","hsa04144,hsa04961,hsa04721,hsa05016","Endocytosis|Endocrine and other factor-regulated calcium reabsorption|Synaptic vesicle cycle|Huntington disease","GO:0005515,GO:0005829,GO:0005886,GO:0006886,GO:0006895,GO:0006897,GO:0009898,GO:0010976,GO:0016020,GO:0016192,GO:0016323,GO:0016324,GO:0019901,GO:0030122,GO:0030130,GO:0030666,GO:0030669,GO:0032433,GO:0035615,GO:0036020,GO:0044877,GO:0045334,GO:0048260,GO:0050750,GO:0072583,GO:0098794,GO:0098884,GO:1900126","protein binding|cytosol|plasma membrane|intracellular protein transport|Golgi to endosome transport|endocytosis|cytoplasmic side of plasma membrane|positive regulation of neuron projection development|membrane|vesicle-mediated transport|basolateral plasma membrane|apical plasma membrane|protein kinase binding|AP-2 adaptor complex|clathrin coat of trans-Golgi network vesicle|endocytic vesicle membrane|clathrin-coated endocytic vesicle membrane|filopodium tip|clathrin adaptor activity|endolysosome membrane|protein-containing complex binding|clathrin-coated endocytic vesicle|positive regulation of receptor-mediated endocytosis|low-density lipoprotein particle receptor binding|clathrin-dependent endocytosis|postsynapse|postsynaptic neurotransmitter receptor internalization|negative regulation of hyaluronan biosynthetic process","WP4159,WP4549,WP5323,WP4829,WP2267,WP437,WP3888","GABA receptor signaling|Fragile X syndrome|Fatty Acids and Lipoproteins Transport in Hepatocytes|mBDNF and proBDNF regulation of GABA neurotransmission|Synaptic vesicle pathway|EGF/EGFR signaling pathway|VEGFA-VEGFR2 signaling","R-HSA-112314,R-HSA-112315,R-HSA-112316,R-HSA-1266738,R-HSA-1266738,R-HSA-1280218,R-HSA-162582,R-HSA-162582,R-HSA-162906,R-HSA-162909,R-HSA-1643685,R-HSA-164938,R-HSA-164952,R-HSA-166520,R-HSA-166520,R-HSA-167590,R-HSA-168256,R-HSA-174824,R-HSA-177504,R-HSA-177504,R-HSA-182218,R-HSA-187037,R-HSA-187037,R-HSA-195721,R-HSA-199991,R-HSA-2132295,R-HSA-2682334,R-HSA-373760,R-HSA-373760,R-HSA-382551,R-HSA-3858494,R-HSA-3928665,R-HSA-399719,R-HSA-399721,R-HSA-4086400,R-HSA-416993,R-HSA-422475,R-HSA-422475,R-HSA-437239,R-HSA-437239,R-HSA-5099900,R-HSA-5140745,R-HSA-5653656,R-HSA-5663205,R-HSA-8856825,R-HSA-8856828,R-HSA-8866427,R-HSA-8964038,R-HSA-8964043,R-HSA-9006934,R-HSA-9006934,R-HSA-9675108,R-HSA-9675108,R-HSA-9679191,R-HSA-9679506,R-HSA-9824446","Neurotransmitter receptors and postsynaptic signal transmission|Transmission across Chemical Synapses|Neuronal System|Developmental Biology|Developmental Biology|Adaptive Immune System|Signal Transduction|Signal Transduction|HIV Infection|Host Interactions of HIV factors|Disease|Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters|The role of Nef in HIV-1 replication and disease pathogenesis|Signaling by NTRKs|Signaling by NTRKs|Nef Mediated CD4 Down-regulation|Immune System|Plasma lipoprotein assembly, remodeling, and clearance|Retrograde neurotrophin signalling|Retrograde neurotrophin signalling|Nef Mediated CD8 Down-regulation|Signaling by NTRK1 (TRKA)|Signaling by NTRK1 (TRKA)|Signaling by WNT|Membrane Trafficking|MHC class II antigen presentation|EPH-Ephrin signaling|L1CAM interactions|L1CAM interactions|Transport of small molecules|Beta-catenin independent WNT signaling|EPH-ephrin mediated repulsion of cells|Trafficking of AMPA receptors|Glutamate binding, activation of AMPA receptors and synaptic plasticity|PCP/CE pathway|Trafficking of GluR2-containing AMPA receptors|Axon guidance|Axon guidance|Recycling pathway of L1|Recycling pathway of L1|WNT5A-dependent internalization of FZD4|WNT5A-dependent internalization of FZD2, FZD5 and ROR2|Vesicle-mediated transport|Infectious disease|Cargo recognition for clathrin-mediated endocytosis|Clathrin-mediated endocytosis|VLDLR internalisation and degradation|LDL clearance|Plasma lipoprotein clearance|Signaling by Receptor Tyrosine Kinases|Signaling by Receptor Tyrosine Kinases|Nervous system development|Nervous system development|Potential therapeutics for SARS|SARS-CoV Infections|Viral Infection Pathways"]
["AP2A2",16.9518466943281,19.2096455979209,19.6741139435259,19.146029683707,16.03815394618,18.7040118824875,19.202399880561,18.8975274030903,15.7848230060087,20.6857129253973,19.5744364819681,17.0949076125299,15.9322847525494,18.8541943540104,17.136461466063,17.2183031273646,16.7780129221323,19.0433829400532,18.0207540497502,17.2393000881572,16.9207405701287,18.0109465732689,15.122712487062,14.7773483095346,16.351010206678,17.8209610036668,13.9343366986665,18.5492706111327,161,"adaptor related protein complex 2 subunit alpha 2","protein_coding","hsa04144,hsa04961,hsa04721,hsa05016","Endocytosis|Endocrine and other factor-regulated calcium reabsorption|Synaptic vesicle cycle|Huntington disease","GO:0003674,GO:0005515,GO:0005829,GO:0005886,GO:0006886,GO:0008289,GO:0009898,GO:0016192,GO:0019901,GO:0030122,GO:0030666,GO:0030667,GO:0030669,GO:0031410,GO:0035615,GO:0036020,GO:0045334,GO:0072583,GO:0097718,GO:0098794,GO:0098884,GO:0101003","molecular_function|protein binding|cytosol|plasma membrane|intracellular protein transport|lipid binding|cytoplasmic side of plasma membrane|vesicle-mediated transport|protein kinase binding|AP-2 adaptor complex|endocytic vesicle membrane|secretory granule membrane|clathrin-coated endocytic vesicle membrane|cytoplasmic vesicle|clathrin adaptor activity|endolysosome membrane|clathrin-coated endocytic vesicle|clathrin-dependent endocytosis|disordered domain specific binding|postsynapse|postsynaptic neurotransmitter receptor internalization|ficolin-1-rich granule membrane","WP4159,WP5323,WP4829,WP2267","GABA receptor signaling|Fatty Acids and Lipoproteins Transport in Hepatocytes|mBDNF and proBDNF regulation of GABA neurotransmission|Synaptic vesicle pathway","R-HSA-112314,R-HSA-112315,R-HSA-112316,R-HSA-1266738,R-HSA-1266738,R-HSA-1280218,R-HSA-162582,R-HSA-162582,R-HSA-162906,R-HSA-162909,R-HSA-1643685,R-HSA-164938,R-HSA-164952,R-HSA-166520,R-HSA-166520,R-HSA-167590,R-HSA-168249,R-HSA-168256,R-HSA-174824,R-HSA-177504,R-HSA-177504,R-HSA-182218,R-HSA-187037,R-HSA-187037,R-HSA-195721,R-HSA-199991,R-HSA-2132295,R-HSA-2682334,R-HSA-373760,R-HSA-373760,R-HSA-382551,R-HSA-3858494,R-HSA-3928665,R-HSA-399719,R-HSA-399721,R-HSA-4086400,R-HSA-416993,R-HSA-422475,R-HSA-422475,R-HSA-437239,R-HSA-437239,R-HSA-5099900,R-HSA-5140745,R-HSA-5653656,R-HSA-5663205,R-HSA-6798695,R-HSA-8856825,R-HSA-8856828,R-HSA-8866427,R-HSA-8964038,R-HSA-8964043,R-HSA-9006934,R-HSA-9006934,R-HSA-9675108,R-HSA-9675108,R-HSA-9679191,R-HSA-9679506,R-HSA-9824446","Neurotransmitter receptors and postsynaptic signal transmission|Transmission across Chemical Synapses|Neuronal System|Developmental Biology|Developmental Biology|Adaptive Immune System|Signal Transduction|Signal Transduction|HIV Infection|Host Interactions of HIV factors|Disease|Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters|The role of Nef in HIV-1 replication and disease pathogenesis|Signaling by NTRKs|Signaling by NTRKs|Nef Mediated CD4 Down-regulation|Innate Immune System|Immune System|Plasma lipoprotein assembly, remodeling, and clearance|Retrograde neurotrophin signalling|Retrograde neurotrophin signalling|Nef Mediated CD8 Down-regulation|Signaling by NTRK1 (TRKA)|Signaling by NTRK1 (TRKA)|Signaling by WNT|Membrane Trafficking|MHC class II antigen presentation|EPH-Ephrin signaling|L1CAM interactions|L1CAM interactions|Transport of small molecules|Beta-catenin independent WNT signaling|EPH-ephrin mediated repulsion of cells|Trafficking of AMPA receptors|Glutamate binding, activation of AMPA receptors and synaptic plasticity|PCP/CE pathway|Trafficking of GluR2-containing AMPA receptors|Axon guidance|Axon guidance|Recycling pathway of L1|Recycling pathway of L1|WNT5A-dependent internalization of FZD4|WNT5A-dependent internalization of FZD2, FZD5 and ROR2|Vesicle-mediated transport|Infectious disease|Neutrophil degranulation|Cargo recognition for clathrin-mediated endocytosis|Clathrin-mediated endocytosis|VLDLR internalisation and degradation|LDL clearance|Plasma lipoprotein clearance|Signaling by Receptor Tyrosine Kinases|Signaling by Receptor Tyrosine Kinases|Nervous system development|Nervous system development|Potential therapeutics for SARS|SARS-CoV Infections|Viral Infection Pathways"]
["AP2B1",52.3613784033789,57.5604860318386,58.3361666324555,53.2834601156763,56.3916203317366,57.0746012327856,59.1590875689488,54.3308369062957,59.4097784215923,55.1223169996299,54.8299219366643,56.5624888043835,58.5084874133996,61.3342972923164,62.531254795483,62.5662656955874,49.3929614108725,52.9705239434473,47.5455611632104,53.4772877980742,49.4990407098958,51.8401779047283,49.4380099371712,49.8774456888711,51.8143925551079,49.4673539962279,48.1330991811463,50.1153528713291,163,"adaptor related protein complex 2 subunit beta 1","protein_coding","hsa04144,hsa04961,hsa04721,hsa05016","Endocytosis|Endocrine and other factor-regulated calcium reabsorption|Synaptic vesicle cycle|Huntington disease","GO:0001822,GO:0003281,GO:0005048,GO:0005515,GO:0005829,GO:0005886,GO:0006886,GO:0009898,GO:0016020,GO:0016192,GO:0030122,GO:0030131,GO:0030276,GO:0030666,GO:0030669,GO:0035615,GO:0035904,GO:0036020,GO:0045334,GO:0048488,GO:0060976,GO:0072583,GO:0098793,GO:0098794,GO:0098884,GO:0098978","kidney development|ventricular septum development|signal sequence binding|protein binding|cytosol|plasma membrane|intracellular protein transport|cytoplasmic side of plasma membrane|membrane|vesicle-mediated transport|AP-2 adaptor complex|clathrin adaptor complex|clathrin binding|endocytic vesicle membrane|clathrin-coated endocytic vesicle membrane|clathrin adaptor activity|aorta development|endolysosome membrane|clathrin-coated endocytic vesicle|synaptic vesicle endocytosis|coronary vasculature development|clathrin-dependent endocytosis|presynapse|postsynapse|postsynaptic neurotransmitter receptor internalization|glutamatergic synapse","WP4159,WP4549,WP5323,WP5287,WP4829,WP5236,WP2267,WP437","GABA receptor signaling|Fragile X syndrome|Fatty Acids and Lipoproteins Transport in Hepatocytes|17q12 copy number variation syndrome|mBDNF and proBDNF regulation of GABA neurotransmission|Markers of kidney cell lineage|Synaptic vesicle pathway|EGF/EGFR signaling pathway","R-HSA-112314,R-HSA-112315,R-HSA-112316,R-HSA-1266738,R-HSA-1266738,R-HSA-1280218,R-HSA-162582,R-HSA-162582,R-HSA-162906,R-HSA-162909,R-HSA-1643685,R-HSA-164938,R-HSA-164952,R-HSA-166520,R-HSA-166520,R-HSA-167590,R-HSA-168256,R-HSA-174824,R-HSA-177504,R-HSA-177504,R-HSA-182218,R-HSA-187037,R-HSA-187037,R-HSA-195721,R-HSA-199991,R-HSA-2132295,R-HSA-2682334,R-HSA-373760,R-HSA-373760,R-HSA-382551,R-HSA-3858494,R-HSA-3928665,R-HSA-399719,R-HSA-399721,R-HSA-4086400,R-HSA-416993,R-HSA-422475,R-HSA-422475,R-HSA-437239,R-HSA-437239,R-HSA-5099900,R-HSA-5140745,R-HSA-5653656,R-HSA-5663205,R-HSA-8856825,R-HSA-8856828,R-HSA-8866427,R-HSA-8964038,R-HSA-8964043,R-HSA-9006934,R-HSA-9006934,R-HSA-9675108,R-HSA-9675108,R-HSA-9679191,R-HSA-9679506,R-HSA-9824446","Neurotransmitter receptors and postsynaptic signal transmission|Transmission across Chemical Synapses|Neuronal System|Developmental Biology|Developmental Biology|Adaptive Immune System|Signal Transduction|Signal Transduction|HIV Infection|Host Interactions of HIV factors|Disease|Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters|The role of Nef in HIV-1 replication and disease pathogenesis|Signaling by NTRKs|Signaling by NTRKs|Nef Mediated CD4 Down-regulation|Immune System|Plasma lipoprotein assembly, remodeling, and clearance|Retrograde neurotrophin signalling|Retrograde neurotrophin signalling|Nef Mediated CD8 Down-regulation|Signaling by NTRK1 (TRKA)|Signaling by NTRK1 (TRKA)|Signaling by WNT|Membrane Trafficking|MHC class II antigen presentation|EPH-Ephrin signaling|L1CAM interactions|L1CAM interactions|Transport of small molecules|Beta-catenin independent WNT signaling|EPH-ephrin mediated repulsion of cells|Trafficking of AMPA receptors|Glutamate binding, activation of AMPA receptors and synaptic plasticity|PCP/CE pathway|Trafficking of GluR2-containing AMPA receptors|Axon guidance|Axon guidance|Recycling pathway of L1|Recycling pathway of L1|WNT5A-dependent internalization of FZD4|WNT5A-dependent internalization of FZD2, FZD5 and ROR2|Vesicle-mediated transport|Infectious disease|Cargo recognition for clathrin-mediated endocytosis|Clathrin-mediated endocytosis|VLDLR internalisation and degradation|LDL clearance|Plasma lipoprotein clearance|Signaling by Receptor Tyrosine Kinases|Signaling by Receptor Tyrosine Kinases|Nervous system development|Nervous system development|Potential therapeutics for SARS|SARS-CoV Infections|Viral Infection Pathways"]
["AP2M1",305.588878696243,293.043096993162,297.457270534518,314.406542502909,277.783065526042,307.708793937513,292.571381854918,309.977139035777,305.326464191382,382.91142678502,355.567816591599,341.706310212639,290.650651736422,309.546428687059,280.77174961572,286.049766231403,360.173310502025,368.417563917382,377.900424901158,345.74284921942,346.126851852673,357.941105212552,341.375553148354,339.906292579986,344.6541417056,380.278920196278,354.475592027003,385.132119090238,1173,"adaptor related protein complex 2 subunit mu 1","protein_coding","hsa04144,hsa04961,hsa04721,hsa05016","Endocytosis|Endocrine and other factor-regulated calcium reabsorption|Synaptic vesicle cycle|Huntington disease","GO:0002092,GO:0005048,GO:0005515,GO:0005765,GO:0005829,GO:0005886,GO:0005905,GO:0006886,GO:0006900,GO:0008289,GO:0009898,GO:0016192,GO:0030122,GO:0030666,GO:0030669,GO:0031410,GO:0031623,GO:0035615,GO:0036020,GO:0044325,GO:0045334,GO:0048488,GO:0050750,GO:0065003,GO:0070062,GO:0072583,GO:0097494,GO:0097718,GO:0098794,GO:0098884,GO:0098894,GO:0098978,GO:1900244,GO:1903077","positive regulation of receptor internalization|signal sequence binding|protein binding|lysosomal membrane|cytosol|plasma membrane|clathrin-coated pit|intracellular protein transport|vesicle budding from membrane|lipid binding|cytoplasmic side of plasma membrane|vesicle-mediated transport|AP-2 adaptor complex|endocytic vesicle membrane|clathrin-coated endocytic vesicle membrane|cytoplasmic vesicle|receptor internalization|clathrin adaptor activity|endolysosome membrane|transmembrane transporter binding|clathrin-coated endocytic vesicle|synaptic vesicle endocytosis|low-density lipoprotein particle receptor binding|protein-containing complex assembly|extracellular exosome|clathrin-dependent endocytosis|regulation of vesicle size|disordered domain specific binding|postsynapse|postsynaptic neurotransmitter receptor internalization|extrinsic component of presynaptic endocytic zone membrane|glutamatergic synapse|positive regulation of synaptic vesicle endocytosis|negative regulation of protein localization to plasma membrane","WP4159,WP4549,WP5323,WP2267,WP437","GABA receptor signaling|Fragile X syndrome|Fatty Acids and Lipoproteins Transport in Hepatocytes|Synaptic vesicle pathway|EGF/EGFR signaling pathway","R-HSA-112314,R-HSA-112315,R-HSA-112316,R-HSA-1266738,R-HSA-1266738,R-HSA-1280218,R-HSA-157858,R-HSA-162582,R-HSA-162582,R-HSA-162906,R-HSA-162909,R-HSA-1643685,R-HSA-164938,R-HSA-164939,R-HSA-164952,R-HSA-166520,R-HSA-166520,R-HSA-167590,R-HSA-168256,R-HSA-174824,R-HSA-177504,R-HSA-177504,R-HSA-182218,R-HSA-187037,R-HSA-187037,R-HSA-190828,R-HSA-190873,R-HSA-195721,R-HSA-196025,R-HSA-199991,R-HSA-2132295,R-HSA-2682334,R-HSA-373760,R-HSA-373760,R-HSA-382551,R-HSA-3858494,R-HSA-3928665,R-HSA-399719,R-HSA-399721,R-HSA-4086400,R-HSA-416993,R-HSA-422475,R-HSA-422475,R-HSA-437239,R-HSA-437239,R-HSA-5099900,R-HSA-5140745,R-HSA-5653656,R-HSA-5663205,R-HSA-8856825,R-HSA-8856828,R-HSA-8866427,R-HSA-8964038,R-HSA-8964043,R-HSA-9006934,R-HSA-9006934,R-HSA-9675108,R-HSA-9675108,R-HSA-9679191,R-HSA-9679506,R-HSA-9824446","Neurotransmitter receptors and postsynaptic signal transmission|Transmission across Chemical Synapses|Neuronal System|Developmental Biology|Developmental Biology|Adaptive Immune System|Gap junction trafficking and regulation|Signal Transduction|Signal Transduction|HIV Infection|Host Interactions of HIV factors|Disease|Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters|Nef mediated downregulation of CD28 cell surface expression|The role of Nef in HIV-1 replication and disease pathogenesis|Signaling by NTRKs|Signaling by NTRKs|Nef Mediated CD4 Down-regulation|Immune System|Plasma lipoprotein assembly, remodeling, and clearance|Retrograde neurotrophin signalling|Retrograde neurotrophin signalling|Nef Mediated CD8 Down-regulation|Signaling by NTRK1 (TRKA)|Signaling by NTRK1 (TRKA)|Gap junction trafficking|Gap junction degradation|Signaling by WNT|Formation of annular gap junctions|Membrane Trafficking|MHC class II antigen presentation|EPH-Ephrin signaling|L1CAM interactions|L1CAM interactions|Transport of small molecules|Beta-catenin independent WNT signaling|EPH-ephrin mediated repulsion of cells|Trafficking of AMPA receptors|Glutamate binding, activation of AMPA receptors and synaptic plasticity|PCP/CE pathway|Trafficking of GluR2-containing AMPA receptors|Axon guidance|Axon guidance|Recycling pathway of L1|Recycling pathway of L1|WNT5A-dependent internalization of FZD4|WNT5A-dependent internalization of FZD2, FZD5 and ROR2|Vesicle-mediated transport|Infectious disease|Cargo recognition for clathrin-mediated endocytosis|Clathrin-mediated endocytosis|VLDLR internalisation and degradation|LDL clearance|Plasma lipoprotein clearance|Signaling by Receptor Tyrosine Kinases|Signaling by Receptor Tyrosine Kinases|Nervous system development|Nervous system development|Potential therapeutics for SARS|SARS-CoV Infections|Viral Infection Pathways"]
["AP2S1",134.708872028264,119.499936226409,134.739626930516,148.952405475399,111.641297286041,131.832361172165,133.496595980067,137.712150819572,111.894899401498,121.420068593038,138.116383769425,125.430889003968,97.2761313572053,123.288527160385,108.312068802469,104.858666163517,159.156724050315,174.56918667461,189.431645342731,158.561918874154,149.203086325267,182.883278190768,157.175464101722,162.997836494821,140.091588391921,199.120173050747,166.990800546202,190.04208267985,1175,"adaptor related protein complex 2 subunit sigma 1","protein_coding","hsa04144,hsa04961,hsa04721,hsa05016","Endocytosis|Endocrine and other factor-regulated calcium reabsorption|Synaptic vesicle cycle|Huntington disease","GO:0005515,GO:0005829,GO:0005886,GO:0006886,GO:0009898,GO:0016192,GO:0030100,GO:0030122,GO:0030666,GO:0030669,GO:0035615,GO:0036020,GO:0043231,GO:0045334,GO:0048268,GO:0048488,GO:0072583,GO:0098793,GO:0098794,GO:0098884","protein binding|cytosol|plasma membrane|intracellular protein transport|cytoplasmic side of plasma membrane|vesicle-mediated transport|regulation of endocytosis|AP-2 adaptor complex|endocytic vesicle membrane|clathrin-coated endocytic vesicle membrane|clathrin adaptor activity|endolysosome membrane|intracellular membrane-bounded organelle|clathrin-coated endocytic vesicle|clathrin coat assembly|synaptic vesicle endocytosis|clathrin-dependent endocytosis|presynapse|postsynapse|postsynaptic neurotransmitter receptor internalization","WP4159,WP4549,WP5323,WP2267,WP437,WP3888","GABA receptor signaling|Fragile X syndrome|Fatty Acids and Lipoproteins Transport in Hepatocytes|Synaptic vesicle pathway|EGF/EGFR signaling pathway|VEGFA-VEGFR2 signaling","R-HSA-112314,R-HSA-112315,R-HSA-112316,R-HSA-1266738,R-HSA-1266738,R-HSA-1280218,R-HSA-162582,R-HSA-162582,R-HSA-162906,R-HSA-162909,R-HSA-1643685,R-HSA-164938,R-HSA-164952,R-HSA-166520,R-HSA-166520,R-HSA-167590,R-HSA-168256,R-HSA-174824,R-HSA-177504,R-HSA-177504,R-HSA-182218,R-HSA-187037,R-HSA-187037,R-HSA-195721,R-HSA-199991,R-HSA-2132295,R-HSA-2682334,R-HSA-373760,R-HSA-373760,R-HSA-382551,R-HSA-3858494,R-HSA-3928665,R-HSA-399719,R-HSA-399721,R-HSA-4086400,R-HSA-416993,R-HSA-422475,R-HSA-422475,R-HSA-437239,R-HSA-437239,R-HSA-5099900,R-HSA-5140745,R-HSA-5653656,R-HSA-5663205,R-HSA-8856825,R-HSA-8856828,R-HSA-8866427,R-HSA-8964038,R-HSA-8964043,R-HSA-9006934,R-HSA-9006934,R-HSA-9675108,R-HSA-9675108,R-HSA-9679191,R-HSA-9679506,R-HSA-9824446","Neurotransmitter receptors and postsynaptic signal transmission|Transmission across Chemical Synapses|Neuronal System|Developmental Biology|Developmental Biology|Adaptive Immune System|Signal Transduction|Signal Transduction|HIV Infection|Host Interactions of HIV factors|Disease|Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters|The role of Nef in HIV-1 replication and disease pathogenesis|Signaling by NTRKs|Signaling by NTRKs|Nef Mediated CD4 Down-regulation|Immune System|Plasma lipoprotein assembly, remodeling, and clearance|Retrograde neurotrophin signalling|Retrograde neurotrophin signalling|Nef Mediated CD8 Down-regulation|Signaling by NTRK1 (TRKA)|Signaling by NTRK1 (TRKA)|Signaling by WNT|Membrane Trafficking|MHC class II antigen presentation|EPH-Ephrin signaling|L1CAM interactions|L1CAM interactions|Transport of small molecules|Beta-catenin independent WNT signaling|EPH-ephrin mediated repulsion of cells|Trafficking of AMPA receptors|Glutamate binding, activation of AMPA receptors and synaptic plasticity|PCP/CE pathway|Trafficking of GluR2-containing AMPA receptors|Axon guidance|Axon guidance|Recycling pathway of L1|Recycling pathway of L1|WNT5A-dependent internalization of FZD4|WNT5A-dependent internalization of FZD2, FZD5 and ROR2|Vesicle-mediated transport|Infectious disease|Cargo recognition for clathrin-mediated endocytosis|Clathrin-mediated endocytosis|VLDLR internalisation and degradation|LDL clearance|Plasma lipoprotein clearance|Signaling by Receptor Tyrosine Kinases|Signaling by Receptor Tyrosine Kinases|Nervous system development|Nervous system development|Potential therapeutics for SARS|SARS-CoV Infections|Viral Infection Pathways"]
["AP3B1",10.1363595126003,9.67921838664975,7.90332628353517,7.911328249568,10.595179680551,8.82397749005654,8.35235568189775,8.219102673414,10.4927363791032,7.74683820416873,7.59867802030584,8.99668244336562,11.1252705978614,8.21863827293145,9.53780583682741,9.21140649469586,10.1058494011755,8.2770510434892,8.97891816280341,10.5606796549278,10.569023499925,9.50256534721414,11.2674940759678,10.3598551952486,10.1283443532853,8.51253800125487,9.51989811928181,8.69366162000824,8546,"adaptor related protein complex 3 subunit beta 1","protein_coding","hsa04142","Lysosome","GO:0000902,GO:0002224,GO:0002244,GO:0003016,GO:0005515,GO:0005739,GO:0005765,GO:0005769,GO:0005794,GO:0006622,GO:0006882,GO:0006886,GO:0006954,GO:0007040,GO:0007283,GO:0007338,GO:0007596,GO:0008089,GO:0016020,GO:0016192,GO:0019903,GO:0030123,GO:0030131,GO:0030665,GO:0030742,GO:0030851,GO:0032438,GO:0034394,GO:0035654,GO:0036211,GO:0042789,GO:0045944,GO:0046907,GO:0048007,GO:0048490,GO:0048872,GO:0051138,GO:0060155,GO:0060425,GO:0090152,GO:0098773,GO:1903232,GO:1904115","cell morphogenesis|toll-like receptor signaling pathway|hematopoietic progenitor cell differentiation|respiratory system process|protein binding|mitochondrion|lysosomal membrane|early endosome|Golgi apparatus|protein targeting to lysosome|intracellular zinc ion homeostasis|intracellular protein transport|inflammatory response|lysosome organization|spermatogenesis|single fertilization|blood coagulation|anterograde axonal transport|membrane|vesicle-mediated transport|protein phosphatase binding|AP-3 adaptor complex|clathrin adaptor complex|clathrin-coated vesicle membrane|GTP-dependent protein binding|granulocyte differentiation|melanosome organization|protein localization to cell surface|clathrin-coated vesicle cargo loading, AP-3-mediated|protein modification process|mRNA transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase II|intracellular transport|antigen processing and presentation, exogenous lipid antigen via MHC class Ib|anterograde synaptic vesicle transport|homeostasis of number of cells|positive regulation of NK T cell differentiation|platelet dense granule organization|lung morphogenesis|establishment of protein localization to mitochondrial membrane involved in mitochondrial fission|skin epidermis development|melanosome assembly|axon cytoplasm",null,null,"R-HSA-1643685,R-HSA-199991,R-HSA-199992,R-HSA-432722,R-HSA-5653656,R-HSA-5663202,R-HSA-6802952,R-HSA-6802957","Disease|Membrane Trafficking|trans-Golgi Network Vesicle Budding|Golgi Associated Vesicle Biogenesis|Vesicle-mediated transport|Diseases of signal transduction by growth factor receptors and second messengers|Signaling by BRAF and RAF1 fusions|Oncogenic MAPK signaling"]
["AP3B2",0.0599860144316953,0.0427924891127775,0.0527972038146381,0.0143825197696705,0.0329713921256555,0.0281649622442785,0.024485304266479,0.0367638117107619,0.0716511363161816,0.1155484410323,0.112826757234026,0.150877286325865,0.0820038662770713,0.110804309059038,0.0871666529127799,0.120861189068566,0.0216273447220628,0.0208136049266413,0.0277201769306516,0.0684995405611073,0.0566179026846732,0.0142547294040531,0.0111036378816591,0.036627933598991,0.0408866752231027,0.0748092229303711,0.0108838808323826,0.0140984485437902,8120,"adaptor related protein complex 3 subunit beta 2","protein_coding","hsa04142","Lysosome","GO:0005769,GO:0005794,GO:0006886,GO:0008089,GO:0016183,GO:0016192,GO:0030123,GO:0030665,GO:0035654,GO:0036465,GO:0046907,GO:0048490,GO:0097708,GO:0098793,GO:1904115","early endosome|Golgi apparatus|intracellular protein transport|anterograde axonal transport|synaptic vesicle coating|vesicle-mediated transport|AP-3 adaptor complex|clathrin-coated vesicle membrane|clathrin-coated vesicle cargo loading, AP-3-mediated|synaptic vesicle recycling|intracellular transport|anterograde synaptic vesicle transport|intracellular vesicle|presynapse|axon cytoplasm","WP2516,WP5408","ATM signaling pathway|15q25 copy number variation"]
["AP3D1",36.1220714493137,44.257613002098,45.1438442287966,44.2939840414692,40.1978837048243,44.6358643279106,44.2042144807333,41.3386008397244,37.214761633145,50.7948964663813,44.6071589165532,39.7645346407861,34.7959300707995,42.8678379960709,37.4186000812091,37.9780772161287,29.6417613400416,36.6144599860386,32.555810069305,34.0875806657019,33.1070301545728,34.2748218643666,26.6641143770097,28.7154778143339,31.1134140072731,32.2649325958261,25.7203883146049,36.3040185291004,8943,"adaptor related protein complex 3 subunit delta 1","protein_coding","hsa04142","Lysosome","GO:0000139,GO:0005515,GO:0005765,GO:0005769,GO:0005794,GO:0006623,GO:0006886,GO:0006896,GO:0008089,GO:0010008,GO:0016020,GO:0016182,GO:0016183,GO:0016192,GO:0030123,GO:0032438,GO:0035646,GO:0035654,GO:0036465,GO:0043195,GO:0045944,GO:0046907,GO:0048007,GO:0048490,GO:0048499,GO:0051138,GO:0060155,GO:0072657,GO:0098794,GO:0098830,GO:0098943,GO:0098978,GO:1903232,GO:1904115","Golgi membrane|protein binding|lysosomal membrane|early endosome|Golgi apparatus|protein targeting to vacuole|intracellular protein transport|Golgi to vacuole transport|anterograde axonal transport|endosome membrane|membrane|synaptic vesicle budding from endosome|synaptic vesicle coating|vesicle-mediated transport|AP-3 adaptor complex|melanosome organization|endosome to melanosome transport|clathrin-coated vesicle cargo loading, AP-3-mediated|synaptic vesicle recycling|terminal bouton|positive regulation of transcription by RNA polymerase II|intracellular transport|antigen processing and presentation, exogenous lipid antigen via MHC class Ib|anterograde synaptic vesicle transport|synaptic vesicle membrane organization|positive regulation of NK T cell differentiation|platelet dense granule organization|protein localization to membrane|postsynapse|presynaptic endosome|neurotransmitter receptor transport, postsynaptic endosome to lysosome|glutamatergic synapse|melanosome assembly|axon cytoplasm","WP5408","15q25 copy number variation"]
["AP3M1",12.0128884113149,11.639612600217,9.17664260900618,9.54366639718025,11.9949914174982,9.87342623529585,9.32434523202931,9.67375785085307,11.3872372289106,8.24192397089058,8.3889118640124,9.91558019268033,11.0292750833931,9.44618632294157,10.7635691821813,10.5709735554771,10.7007618963174,9.95369136503867,10.5644217589117,12.0750547361432,10.6581723202508,10.7654187312823,11.5625279585601,11.2326808740683,10.5329124347354,9.68659851181178,9.52325441260165,9.21158754631226,26985,"adaptor related protein complex 3 subunit mu 1","protein_coding","hsa04142","Lysosome","GO:0005515,GO:0005764,GO:0005765,GO:0005769,GO:0005794,GO:0006622,GO:0006897,GO:0008089,GO:0016192,GO:0030123,GO:0030131,GO:0030659,GO:0031267,GO:0031410,GO:0035654,GO:0046907,GO:0048490,GO:0060155,GO:1903232,GO:1904115","protein binding|lysosome|lysosomal membrane|early endosome|Golgi apparatus|protein targeting to lysosome|endocytosis|anterograde axonal transport|vesicle-mediated transport|AP-3 adaptor complex|clathrin adaptor complex|cytoplasmic vesicle membrane|small GTPase binding|cytoplasmic vesicle|clathrin-coated vesicle cargo loading, AP-3-mediated|intracellular transport|anterograde synaptic vesicle transport|platelet dense granule organization|melanosome assembly|axon cytoplasm","WP5323","Fatty Acids and Lipoproteins Transport in Hepatocytes","R-HSA-390466,R-HSA-390471,R-HSA-391251,R-HSA-392499","Chaperonin-mediated protein folding|Association of TriC/CCT with target proteins during biosynthesis|Protein folding|Metabolism of proteins"]
["AP3M2",4.97094516815989,4.54699336290597,4.50481725138931,5.26415152422175,5.07263638060415,4.37727085617193,3.97133002392506,4.54174348992699,5.00608513361025,4.65578174904801,4.17100655961465,5.29466650174331,5.23119532420206,4.89243082896335,4.9606757779225,4.87690347825418,4.52169761321366,4.3735996989659,3.43881252987289,4.53972679271723,4.42212484648718,4.02338005958292,3.57918214287393,4.10037906397097,4.14332209258721,4.66106900770191,3.37008505323368,3.99046342238762,10947,"adaptor related protein complex 3 subunit mu 2","protein_coding","hsa04142","Lysosome","GO:0005769,GO:0005794,GO:0006886,GO:0006897,GO:0008089,GO:0016183,GO:0030119,GO:0030123,GO:0030131,GO:0030659,GO:0031410,GO:0035654,GO:0036465,GO:0046907,GO:0048490,GO:0098793,GO:1904115","early endosome|Golgi apparatus|intracellular protein transport|endocytosis|anterograde axonal transport|synaptic vesicle coating|AP-type membrane coat adaptor complex|AP-3 adaptor complex|clathrin adaptor complex|cytoplasmic vesicle membrane|cytoplasmic vesicle|clathrin-coated vesicle cargo loading, AP-3-mediated|synaptic vesicle recycling|intracellular transport|anterograde synaptic vesicle transport|presynapse|axon cytoplasm","WP5323,WP5408","Fatty Acids and Lipoproteins Transport in Hepatocytes|15q25 copy number variation"]
["AP3S1",10.9592049219603,10.3926622750832,12.2884803069649,10.7476659727318,10.7249821420084,10.2881558674219,12.7995054177692,11.6712062179961,11.0931174459853,6.47787087850635,10.1390645538633,9.81846489267858,12.1716661379104,10.2470903105802,11.2130389107516,11.1224867473518,12.232486309539,10.9363707320174,14.8365796723292,12.9069363283968,12.5159514207578,12.3507527794787,18.4094766969909,14.3981916134791,13.0258311632007,11.9419912441643,16.6190000199684,11.47455241868,1176,"adaptor related protein complex 3 subunit sigma 1","protein_coding","hsa04142","Lysosome","GO:0005515,GO:0005769,GO:0005794,GO:0006886,GO:0006896,GO:0008089,GO:0008286,GO:0016183,GO:0016192,GO:0030119,GO:0030123,GO:0030133,GO:0030659,GO:0035654,GO:0036465,GO:0043231,GO:0046907,GO:0048490,GO:0060155,GO:0098793,GO:1903232,GO:1904115","protein binding|early endosome|Golgi apparatus|intracellular protein transport|Golgi to vacuole transport|anterograde axonal transport|insulin receptor signaling pathway|synaptic vesicle coating|vesicle-mediated transport|AP-type membrane coat adaptor complex|AP-3 adaptor complex|transport vesicle|cytoplasmic vesicle membrane|clathrin-coated vesicle cargo loading, AP-3-mediated|synaptic vesicle recycling|intracellular membrane-bounded organelle|intracellular transport|anterograde synaptic vesicle transport|platelet dense granule organization|presynapse|melanosome assembly|axon cytoplasm","WP5413,WP5408","IL-24 Signaling pathway|15q25 copy number variation","R-HSA-199991,R-HSA-199992,R-HSA-432722,R-HSA-5653656","Membrane Trafficking|trans-Golgi Network Vesicle Budding|Golgi Associated Vesicle Biogenesis|Vesicle-mediated transport"]
["AP3S2",0.0632204218037453,0.0601331101895982,0.022828305696509,0.0513040541486218,0.047520257659002,0.0548004903129252,0.0136117113741386,0.0190749995453998,0.0586995455753596,0.0468379764467708,0.0594551517604663,0.0342488445822696,0.00462477389054854,0.0324546558282833,0.0361813160782471,0.0138328991956414,0.0327290955517896,0.0134989914687489,0.0359567151599107,0.0187058764163188,0.0413104871315758,0.0138676940846755,0.0672134337102535,0.014253374124666,0.0241069977575409,0.0646916005615934,0.0141178248574474,0.022859427437726,10239,"ARPIN-AP3S2 readthrough","protein_coding","hsa04142","Lysosome","GO:0005769,GO:0005794,GO:0006886,GO:0006896,GO:0008089,GO:0016183,GO:0016192,GO:0030123,GO:0030659,GO:0035654,GO:0036465,GO:0043231,GO:0046907,GO:0048490,GO:0060155,GO:0098793,GO:1903232,GO:1904115","early endosome|Golgi apparatus|intracellular protein transport|Golgi to vacuole transport|anterograde axonal transport|synaptic vesicle coating|vesicle-mediated transport|AP-3 adaptor complex|cytoplasmic vesicle membrane|clathrin-coated vesicle cargo loading, AP-3-mediated|synaptic vesicle recycling|intracellular membrane-bounded organelle|intracellular transport|anterograde synaptic vesicle transport|platelet dense granule organization|presynapse|melanosome assembly|axon cytoplasm"]
["AP4B1",2.57319324111241,3.15180977512993,3.4413189686089,3.90214346035367,2.85826789484187,3.44210767161345,3.44725382449574,3.63033892116374,2.48504720421678,2.83841194410305,3.4816793087001,3.4001655186487,2.64229293308205,3.13118141539166,2.88393846254383,2.66220797502237,3.1224172599208,3.55436974786587,3.54358586227612,3.48959091126932,2.90615213705425,3.40058839778278,3.14100787455371,3.80313901028697,3.19798960950893,3.27392681726308,3.24200726638273,3.9560200603165,10717,"adaptor related protein complex 4 subunit beta 1","protein_coding","hsa04142","Lysosome","GO:0005515,GO:0005802,GO:0005829,GO:0006605,GO:0008104,GO:0016192,GO:0030124,GO:0030131,GO:0030276,GO:0031904,GO:0032588,GO:0061938,GO:0098541","protein binding|trans-Golgi network|cytosol|protein targeting|protein localization|vesicle-mediated transport|AP-4 adaptor complex|clathrin adaptor complex|clathrin binding|endosome lumen|trans-Golgi network membrane|protein localization to somatodendritic compartment|cytoplasmic side of trans-Golgi network transport vesicle membrane",null,null,"R-HSA-199991,R-HSA-199992,R-HSA-432720,R-HSA-432722,R-HSA-5653656","Membrane Trafficking|trans-Golgi Network Vesicle Budding|Lysosome Vesicle Biogenesis|Golgi Associated Vesicle Biogenesis|Vesicle-mediated transport"]
["AP4B1-AS1",0.138043932768935,0.071619645419197,0.0589093568322855,0.0120356514366772,0.0735767564815219,0.0235691432188504,0.0351255661763735,0.0984476000746288,0.126230439604367,0.0120867273484381,0,0.0883805146738922,0.0238688283755219,0.035893088039939,0.0466836673700475,0.0237975668036749,0.0482621379738148,0,0.0579923394237037,0.048271263024048,0.0118448184445647,0.0357861398097562,0.0247781366757073,0.085823272720541,0.0746508874693013,0.0119242332373274,0.048575483044588,0.0589896677315247,100287722,"AP4B1 antisense RNA 1","non_coding"]
["AP4E1",3.50679714765927,3.16145687378406,2.50875143637417,2.23980792836189,3.41238685424323,2.67432321261017,2.35652291061591,2.32959454405276,2.98610755354586,2.33392669853648,2.12403858825157,2.45643240206254,3.45677292552734,2.25795013860372,3.2885359830083,2.87724992034014,2.16442319073088,2.26926894380566,2.3039244486942,2.55203822336196,2.45305482257424,2.52610103902067,2.95244082715817,2.4246955902639,2.35531457039549,2.35124375662614,2.3520454696147,1.92714534277285,23431,"adaptor related protein complex 4 subunit epsilon 1","protein_coding","hsa04142","Lysosome","GO:0005515,GO:0005802,GO:0006605,GO:0008104,GO:0016192,GO:0030124,GO:0031904,GO:0032588,GO:0140312","protein binding|trans-Golgi network|protein targeting|protein localization|vesicle-mediated transport|AP-4 adaptor complex|endosome lumen|trans-Golgi network membrane|cargo adaptor activity",null,null,"R-HSA-199991,R-HSA-199992,R-HSA-432720,R-HSA-432722,R-HSA-5653656","Membrane Trafficking|trans-Golgi Network Vesicle Budding|Lysosome Vesicle Biogenesis|Golgi Associated Vesicle Biogenesis|Vesicle-mediated transport"]
["AP4M1",5.02711675254029,3.97391565825216,5.14695563860533,5.32297310399393,4.85254284720295,4.61226987089813,5.14026543977618,5.74895032134391,4.85843401754282,6.34662843601606,5.92880724568218,5.80951698198417,4.03779008242669,5.7318584091199,4.76364000776146,4.84376442385445,5.26434351867502,4.90912756086242,6.61765083248739,6.01006420977839,4.89232792954631,5.52105823304853,5.44574487329744,5.40912794102943,5.16584893816672,6.53241230587319,6.14654918328438,6.29078423351842,9179,"adaptor related protein complex 4 subunit mu 1","protein_coding","hsa04142","Lysosome","GO:0000045,GO:0005515,GO:0005769,GO:0005802,GO:0005829,GO:0006605,GO:0006622,GO:0006886,GO:0006892,GO:0006895,GO:0008104,GO:0008320,GO:0016192,GO:0019904,GO:0030124,GO:0030131,GO:0031410,GO:0031904,GO:0032588,GO:0070062,GO:0071806,GO:0090160,GO:1903361","autophagosome assembly|protein binding|early endosome|trans-Golgi network|cytosol|protein targeting|protein targeting to lysosome|intracellular protein transport|post-Golgi vesicle-mediated transport|Golgi to endosome transport|protein localization|protein transmembrane transporter activity|vesicle-mediated transport|protein domain specific binding|AP-4 adaptor complex|clathrin adaptor complex|cytoplasmic vesicle|endosome lumen|trans-Golgi network membrane|extracellular exosome|protein transmembrane transport|Golgi to lysosome transport|protein localization to basolateral plasma membrane",null,null,"R-HSA-199991,R-HSA-199992,R-HSA-432720,R-HSA-5653656","Membrane Trafficking|trans-Golgi Network Vesicle Budding|Lysosome Vesicle Biogenesis|Vesicle-mediated transport"]
["AP4S1",1.2104033387189,1.17663735449358,1.34363242662755,1.06958567223848,1.37616170058491,1.44044672497448,1.5447908558731,1.11973371731309,1.50847692463219,1.04479705565756,1.09535910433524,1.34413830389622,1.61441178582159,1.32452691730551,1.70266185126816,1.33892059915158,1.59921316805664,1.35238469966722,1.73430668527204,1.57023378659121,1.59869925987314,1.51957186721122,1.73979466247325,1.7552031304183,1.94720547026674,1.49368447986881,1.80481034362079,1.90368870219858,11154,"adaptor related protein complex 4 subunit sigma 1","protein_coding","hsa04142","Lysosome","GO:0005802,GO:0006605,GO:0008104,GO:0016192,GO:0030124,GO:0031904,GO:0032588,GO:0043231","trans-Golgi network|protein targeting|protein localization|vesicle-mediated transport|AP-4 adaptor complex|endosome lumen|trans-Golgi network membrane|intracellular membrane-bounded organelle",null,null,"R-HSA-199991,R-HSA-199992,R-HSA-432720,R-HSA-5653656","Membrane Trafficking|trans-Golgi Network Vesicle Budding|Lysosome Vesicle Biogenesis|Vesicle-mediated transport"]
["AP5B1",3.69972123142735,3.65496187604185,3.51331353074502,3.60750891469158,3.07557166742316,3.4488409865344,3.25363389114641,3.09018272005026,3.01054173079356,4.4187966947279,3.54838029937706,3.32591469023146,2.98953997760785,3.26581849132678,3.34015620648645,3.40903212916816,2.60652882529239,3.03015871228088,3.04101857908202,2.84469883593666,2.73745633011643,3.03950450056366,2.53154459546808,2.80333306639716,2.85628412817354,2.66774139347817,2.64961165988755,2.70120618560924,91056,"adaptor related protein complex 5 subunit beta 1","protein_coding",null,null,"GO:0005515,GO:0005765,GO:0005770,GO:0015031,GO:0016192,GO:0016197,GO:0030119,GO:0044599","protein binding|lysosomal membrane|late endosome|protein transport|vesicle-mediated transport|endosomal transport|AP-type membrane coat adaptor complex|AP-5 adaptor complex"]
["AP5M1",2.83918346145429,2.44790387832511,2.00559414725005,1.70623070629479,2.82802728522606,2.27051748635011,2.15118956255495,1.89947089140847,2.79134712422883,1.65834046878643,1.94873351095714,1.86360617545342,2.80891080957705,1.94061088690513,2.6233897386686,2.63987441472272,2.48975322449524,2.04015934913101,2.45685755271105,2.67957786909394,2.98016155237387,2.53334135605251,3.50814470072448,2.93710106432742,2.75808175677584,2.25608964193912,3.23044085176489,2.28815975678953,55745,"adaptor related protein complex 5 subunit mu 1","protein_coding",null,null,"GO:0005764,GO:0005765,GO:0005770,GO:0005829,GO:0015031,GO:0016020,GO:0016192,GO:0016197,GO:0030119,GO:0031902,GO:0044599","lysosome|lysosomal membrane|late endosome|cytosol|protein transport|membrane|vesicle-mediated transport|endosomal transport|AP-type membrane coat adaptor complex|late endosome membrane|AP-5 adaptor complex"]
["AP5S1",3.4705880624746,3.34330668833791,3.26756886334598,2.85097024678998,2.91440923305282,3.18961887599565,3.33461620375923,3.46609189915272,3.25788113872548,3.94562239872601,3.19898057627177,3.37266472341085,2.86449512502098,3.42158016727178,3.05340895493023,3.25325098317744,3.21352757248251,3.65822833384802,3.24404140813702,3.12406352829904,3.18266025840247,3.87998197036107,3.48950299418833,2.95238695134501,3.09869444599163,3.73331430798138,3.2820965003148,4.11088508327902,55317,"adaptor related protein complex 5 subunit sigma 1","protein_coding",null,null,"GO:0000724,GO:0005515,GO:0005654,GO:0005764,GO:0005765,GO:0005770,GO:0005829,GO:0015031,GO:0016192,GO:0016197,GO:0030119,GO:0031902,GO:0044599","double-strand break repair via homologous recombination|protein binding|nucleoplasm|lysosome|lysosomal membrane|late endosome|cytosol|protein transport|vesicle-mediated transport|endosomal transport|AP-type membrane coat adaptor complex|late endosome membrane|AP-5 adaptor complex"]
["AP5Z1",9.14629404617762,10.6890604455538,13.1915534167882,11.9747613585461,10.3284785824912,11.0336328737709,11.508276472631,11.9472813111728,10.1415028300006,13.833407009357,13.5396636341667,10.9726659413267,10.2049019365814,13.0379743457501,11.4350414705369,11.7045291451936,6.83895182603335,8.15599184650547,8.6694865884605,7.28563437349285,7.70780833454501,8.60583847435876,6.69504446310113,6.50646979489663,6.30302461549446,7.58345001823421,7.40703635378219,8.05314268934031,9907,"adaptor related protein complex 5 subunit zeta 1","protein_coding",null,null,"GO:0000724,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005770,GO:0015031,GO:0016192,GO:0016197,GO:0016607,GO:0030119,GO:0044599","double-strand break repair via homologous recombination|protein binding|nucleus|nucleoplasm|cytoplasm|late endosome|protein transport|vesicle-mediated transport|endosomal transport|nuclear speck|AP-type membrane coat adaptor complex|AP-5 adaptor complex"]
["APAF1",5.60992284190505,4.93152144355318,3.05943839368726,2.87174727487454,5.17452142256234,4.1070294294888,2.60033486190099,2.91521822320671,5.12526372705832,3.67202595407249,2.73199489912838,4.08025161272261,5.25343294141438,3.37254195734761,3.89794389714479,4.16377294701001,4.41107240589198,3.98061113875821,2.91274058224883,4.36723758457242,3.95265234122218,3.84478999860619,4.77275391337184,3.93775533439249,4.21209518318633,3.06584934429783,3.3989380713454,2.79487165511787,317,"apoptotic peptidase activating factor 1","protein_coding","hsa04210,hsa04215,hsa04115,hsa05200,hsa05222,hsa05161,hsa05160,hsa05164,hsa05162,hsa05168,hsa05169,hsa05134,hsa05152,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022,hsa05417,hsa01524","Apoptosis|Apoptosis - multiple species|p53 signaling pathway|Pathways in cancer|Small cell lung cancer|Hepatitis B|Hepatitis C|Influenza A|Measles|Herpes simplex virus 1 infection|Epstein-Barr virus infection|Legionellosis|Tuberculosis|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases|Lipid and atherosclerosis|Platinum drug resistance","GO:0000166,GO:0001666,GO:0001822,GO:0001843,GO:0005515,GO:0005524,GO:0005576,GO:0005634,GO:0005829,GO:0006915,GO:0006919,GO:0007399,GO:0007584,GO:0008635,GO:0008656,GO:0010659,GO:0030154,GO:0030900,GO:0031072,GO:0032991,GO:0034774,GO:0042802,GO:0042981,GO:0043065,GO:0043293,GO:0043531,GO:0051402,GO:0070059,GO:0070062,GO:0071560,GO:0072432,GO:0097193,GO:1902510,GO:1904813,GO:2001235","nucleotide binding|response to hypoxia|kidney development|neural tube closure|protein binding|ATP binding|extracellular region|nucleus|cytosol|apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|nervous system development|response to nutrient|activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c|cysteine-type endopeptidase activator activity involved in apoptotic process|cardiac muscle cell apoptotic process|cell differentiation|forebrain development|heat shock protein binding|protein-containing complex|secretory granule lumen|identical protein binding|regulation of apoptotic process|positive regulation of apoptotic process|apoptosome|ADP binding|neuron apoptotic process|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|extracellular exosome|cellular response to transforming growth factor beta stimulus|response to G1 DNA damage checkpoint signaling|intrinsic apoptotic signaling pathway|regulation of apoptotic DNA fragmentation|ficolin-1-rich granule lumen|positive regulation of apoptotic signaling pathway","WP3959,WP4963,WP5124,WP4630,WP4666,WP2507,WP5090,WP384,WP2447,WP2059,WP3982,WP2371,WP3941,WP314,WP5322,WP4658,WP4864,WP707,WP254,WP231,WP1772,WP4838,WP1530","DNA IR-double strand breaks and cellular response via ATM|p53 transcriptional gene network|Alzheimer's disease|Measles virus infection|Hepatitis B infection|Nanomaterial induced apoptosis|Complement system in neuronal development and plasticity|Apoptosis modulation by HSP70|Amyotrophic lateral sclerosis (ALS)|Alzheimer's disease and miRNA effects|miRNA regulation of p53 pathway in prostate cancer|Parkinson's disease pathway|Oxidative damage response|Fas ligand pathway and stress induction of heat shock proteins|CKAP4 signaling pathway map|Small cell lung cancer|Host-pathogen interaction of human coronaviruses - apoptosis|DNA damage response|Apoptosis|TNF-alpha signaling pathway|Apoptosis modulation and signaling|Regucalcin in proximal tubule epithelial kidney cells|miRNA regulation of DNA damage response","R-HSA-109581,R-HSA-109581,R-HSA-109606,R-HSA-109606,R-HSA-111458,R-HSA-111458,R-HSA-111459,R-HSA-111461,R-HSA-111461,R-HSA-111463,R-HSA-111464,R-HSA-111469,R-HSA-111471,R-HSA-111471,R-HSA-168249,R-HSA-168256,R-HSA-212436,R-HSA-3700989,R-HSA-5357801,R-HSA-5357801,R-HSA-5633008,R-HSA-6798695,R-HSA-6803207,R-HSA-73857,R-HSA-74160,R-HSA-8953750,R-HSA-9627069,R-HSA-9627069","Apoptosis|Apoptosis|Intrinsic Pathway for Apoptosis|Intrinsic Pathway for Apoptosis|Formation of apoptosome|Formation of apoptosome|Activation of caspases through apoptosome-mediated cleavage|Cytochrome c-mediated apoptotic response|Cytochrome c-mediated apoptotic response|SMAC (DIABLO) binds to IAPs |SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes |SMAC, XIAP-regulated apoptotic response|Apoptotic factor-mediated response|Apoptotic factor-mediated response|Innate Immune System|Immune System|Generic Transcription Pathway|Transcriptional Regulation by TP53|Programmed Cell Death|Programmed Cell Death|TP53 Regulates Transcription of Cell Death Genes|Neutrophil degranulation|TP53 Regulates Transcription of Caspase Activators and Caspases|RNA Polymerase II Transcription|Gene expression (Transcription)|Transcriptional Regulation by E2F6|Regulation of the apoptosome activity|Regulation of the apoptosome activity"]
["APBA1",2.72582561031438,2.92611181000966,2.70613727270035,2.31382193913831,3.05344048298277,2.72426561594429,2.12220809008063,2.44623016112952,2.72680798954796,3.02755716701718,2.13565003012261,2.57733739841334,2.55677448165706,2.8475944501748,2.71533106968477,2.82491503817545,1.86784287949924,1.81826566227888,1.50604557202613,2.0976865296292,2.30177150261128,1.86792858025936,1.43936672385896,1.67579509732055,1.80779273234898,1.47748326164144,1.32066988360069,1.75279853765825,320,"amyloid beta precursor protein binding family A member 1","protein_coding",null,null,"GO:0001540,GO:0001701,GO:0005515,GO:0005634,GO:0005737,GO:0005794,GO:0005829,GO:0005886,GO:0006886,GO:0007155,GO:0007268,GO:0007399,GO:0007626,GO:0008021,GO:0008088,GO:0010468,GO:0014047,GO:0014051,GO:0035264,GO:0043197,GO:0048471,GO:0048787,GO:0065003,GO:0098685,GO:0098978,GO:0099171","amyloid-beta binding|in utero embryonic development|protein binding|nucleus|cytoplasm|Golgi apparatus|cytosol|plasma membrane|intracellular protein transport|cell adhesion|chemical synaptic transmission|nervous system development|locomotory behavior|synaptic vesicle|axo-dendritic transport|regulation of gene expression|glutamate secretion|gamma-aminobutyric acid secretion|multicellular organism growth|dendritic spine|perinuclear region of cytoplasm|presynaptic active zone membrane|protein-containing complex assembly|Schaffer collateral - CA1 synapse|glutamatergic synapse|presynaptic modulation of chemical synaptic transmission",null,null,"R-HSA-112310,R-HSA-112314,R-HSA-112315,R-HSA-112315,R-HSA-112316,R-HSA-112316,R-HSA-212676,R-HSA-442755,R-HSA-6794361,R-HSA-6794362,R-HSA-9609736","Neurotransmitter release cycle|Neurotransmitter receptors and postsynaptic signal transmission|Transmission across Chemical Synapses|Transmission across Chemical Synapses|Neuronal System|Neuronal System|Dopamine Neurotransmitter Release Cycle|Activation of NMDA receptors and postsynaptic events|Neurexins and neuroligins|Protein-protein interactions at synapses|Assembly and cell surface presentation of NMDA receptors"]
["APBA2",4.33077862362183,4.78495357351995,4.11613386917144,4.48511454930916,4.2077185165123,4.62349705882502,4.20573402467935,4.29115317640504,2.4306800819578,3.56842720067204,3.15916643327315,2.84952538872131,2.6073596572628,2.93573448005101,2.98624326735157,2.86499735375776,3.12283598419968,2.97486532704674,2.61005913030944,2.78693562060404,3.20170435180119,2.98959641772939,2.5522540317559,2.61424324488217,2.82841131273806,3.023678155802,2.23085205576794,3.57604951159069,321,"amyloid beta precursor protein binding family A member 2","protein_coding",null,null,"GO:0001540,GO:0001701,GO:0005515,GO:0005737,GO:0005886,GO:0007268,GO:0007399,GO:0007626,GO:0010468,GO:0015031,GO:0035264,GO:0042802,GO:0043197,GO:0098685,GO:0098793,GO:0099171","amyloid-beta binding|in utero embryonic development|protein binding|cytoplasm|plasma membrane|chemical synaptic transmission|nervous system development|locomotory behavior|regulation of gene expression|protein transport|multicellular organism growth|identical protein binding|dendritic spine|Schaffer collateral - CA1 synapse|presynapse|presynaptic modulation of chemical synaptic transmission","WP4754,WP5407","IL-18 signaling pathway|15q11q13 copy number variation","R-HSA-112316,R-HSA-6794361,R-HSA-6794362","Neuronal System|Neurexins and neuroligins|Protein-protein interactions at synapses"]
["APBA3",4.1425707301096,5.24247024476964,5.57340290133992,5.62553936301814,5.00515228023074,4.82104554308876,5.15330810810361,4.62927856743219,4.72482082922646,7.84324883435512,6.44868333244651,5.08206754330465,5.18538800962937,5.92977701238453,4.5001501947738,4.97967211141872,5.78701914487245,5.35087649715777,7.72275148144815,5.68597013581471,6.3161094136298,6.6973980008581,6.83935154534132,6.29561050993447,5.00801557863232,6.70609688716292,6.70399088871804,6.92354808435067,9546,"amyloid beta precursor protein binding family A member 3","protein_coding",null,null,"GO:0001540,GO:0001701,GO:0004857,GO:0005515,GO:0005737,GO:0005886,GO:0007268,GO:0010468,GO:0015031,GO:0019899,GO:0043086,GO:0043197,GO:0048471","amyloid-beta binding|in utero embryonic development|enzyme inhibitor activity|protein binding|cytoplasm|plasma membrane|chemical synaptic transmission|regulation of gene expression|protein transport|enzyme binding|negative regulation of catalytic activity|dendritic spine|perinuclear region of cytoplasm",null,null,"R-HSA-112316,R-HSA-6794361,R-HSA-6794362","Neuronal System|Neurexins and neuroligins|Protein-protein interactions at synapses"]
["APBB1",18.6735792691069,19.1797410432609,20.9387417924675,20.9853618449904,19.2035334416772,20.7597013471634,20.4992804205316,21.2868323261366,24.3574256260588,30.1322112796562,32.014188568276,26.3550694757546,23.1503766414187,26.6111354728108,24.57895087033,24.037922228392,20.2194227041297,24.8719671945301,22.9649664117866,22.1492690385844,20.4394187079408,23.9337703047649,19.9067550052632,19.8104634374071,20.6633656515026,23.8532361679499,19.2213186407435,23.777555269223,322,"amyloid beta precursor protein binding family B member 1","protein_coding","hsa05010","Alzheimer disease","GO:0000122,GO:0001540,GO:0003682,GO:0003713,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005783,GO:0005886,GO:0006325,GO:0006355,GO:0006915,GO:0006939,GO:0006974,GO:0007165,GO:0007409,GO:0008134,GO:0016607,GO:0030027,GO:0030426,GO:0031625,GO:0042393,GO:0043065,GO:0045202,GO:0045893,GO:0045944,GO:0050714,GO:0050750,GO:0070064,GO:1902807","negative regulation of transcription by RNA polymerase II|amyloid-beta binding|chromatin binding|transcription coactivator activity|protein binding|nucleus|nucleoplasm|cytoplasm|endoplasmic reticulum|plasma membrane|chromatin organization|regulation of DNA-templated transcription|apoptotic process|smooth muscle contraction|DNA damage response|signal transduction|axonogenesis|transcription factor binding|nuclear speck|lamellipodium|growth cone|ubiquitin protein ligase binding|histone binding|positive regulation of apoptotic process|synapse|positive regulation of DNA-templated transcription|positive regulation of transcription by RNA polymerase II|positive regulation of protein secretion|low-density lipoprotein particle receptor binding|proline-rich region binding|negative regulation of cell cycle G1/S phase transition","WP5124,WP2059,WP5381","Alzheimer's disease|Alzheimer's disease and miRNA effects|Smith-Magenis and Potocki-Lupski syndrome copy number variation","R-HSA-5693532,R-HSA-5693565,R-HSA-5693606,R-HSA-73894","DNA Double-Strand Break Repair|Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks|DNA Double Strand Break Response|DNA Repair"]
["APBB1IP",6.4616355645865,8.72408163136894,7.86421242985896,8.74937929205027,6.7074661914204,7.92134432890418,7.75111838011359,8.15624917492606,1.42238942567964,1.27683395136615,1.38528754185903,1.20534187631441,1.38214863677448,1.66648534954978,1.33336717273095,1.39664408454354,0.736432754525031,1.19029303851573,0.871292118607147,1.28427937383325,0.889798295743825,1.21346954225577,0.775569217915036,1.02655621696582,1.1293632258015,1.31565343246736,0.779225071178649,1.5325193328739,54518,"amyloid beta precursor protein binding family B member 1 interacting protein","protein_coding","hsa04015,hsa04611","Rap1 signaling pathway|Platelet activation","GO:0002291,GO:0005515,GO:0005829,GO:0005856,GO:0005886,GO:0005925,GO:0007165,GO:0030027,GO:0042101,GO:0045785","T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell|protein binding|cytosol|cytoskeleton|plasma membrane|focal adhesion|signal transduction|lamellipodium|T cell receptor complex|positive regulation of cell adhesion","WP3945","TYROBP causal network in microglia","R-HSA-109582,R-HSA-162582,R-HSA-1643685,R-HSA-354192,R-HSA-354194,R-HSA-372708,R-HSA-5663202,R-HSA-5673001,R-HSA-5674135,R-HSA-5683057,R-HSA-5684996,R-HSA-6802946,R-HSA-6802948,R-HSA-6802949,R-HSA-6802952,R-HSA-6802955,R-HSA-6802957,R-HSA-76002,R-HSA-76009,R-HSA-9649948,R-HSA-9656223","Hemostasis|Signal Transduction|Disease|Integrin signaling|GRB2:SOS provides linkage to MAPK signaling for Integrins |p130Cas linkage to MAPK signaling for integrins|Diseases of signal transduction by growth factor receptors and second messengers|RAF/MAP kinase cascade|MAP2K and MAPK activation|MAPK family signaling cascades|MAPK1/MAPK3 signaling|Signaling by moderate kinase activity BRAF mutants|Signaling by high-kinase activity BRAF mutants|Signaling by RAS mutants|Signaling by BRAF and RAF1 fusions|Paradoxical activation of RAF signaling by kinase inactive BRAF|Oncogenic MAPK signaling|Platelet activation, signaling and aggregation|Platelet Aggregation (Plug Formation)|Signaling downstream of RAS mutants|Signaling by RAF1 mutants"]
["APBB2",3.84368548197579,3.69251959905034,3.06087729479992,2.66860878094531,4.12889586069445,3.76272093290423,3.36661095382722,3.09344489977998,2.71191281916115,2.30765637368687,1.90785481862639,2.13038916418414,2.8516447250145,2.4857146264467,2.80208027868124,3.19140885460455,2.50904229746502,2.31689766146717,1.49108283390063,2.49104738467963,2.54698620424578,2.33453885413008,2.13547903718635,2.50266848084599,2.82293115504236,2.05307514200227,1.91432742620535,2.0358433429134,323,"amyloid beta precursor protein binding family B member 2","protein_coding",null,null,"GO:0000122,GO:0001540,GO:0005515,GO:0005634,GO:0005737,GO:0005769,GO:0005783,GO:0005794,GO:0006355,GO:0006939,GO:0008134,GO:0016020,GO:0030027,GO:0030426,GO:0035556,GO:0036438,GO:0045202,GO:0045944,GO:0050808,GO:1901988","negative regulation of transcription by RNA polymerase II|amyloid-beta binding|protein binding|nucleus|cytoplasm|early endosome|endoplasmic reticulum|Golgi apparatus|regulation of DNA-templated transcription|smooth muscle contraction|transcription factor binding|membrane|lamellipodium|growth cone|intracellular signal transduction|maintenance of lens transparency|synapse|positive regulation of transcription by RNA polymerase II|synapse organization|negative regulation of cell cycle phase transition"]
["APBB3",4.30898607849611,5.70700745156819,8.38486001981499,6.36703857879687,5.16527976868141,6.22245094945028,6.00699412941157,6.51003054303905,5.59421398773052,8.78278223548142,7.70418139334447,7.10770836915889,5.02696159246331,8.13258650368128,6.45366992344535,7.66045002412163,4.67272584557257,5.30821075708863,5.1633015898349,4.80610856381115,4.32714555154579,4.94121449027461,5.25556714016106,4.35661356679003,4.70668295242088,4.66561114013083,4.63033603107273,4.98124981965932,10307,"amyloid beta precursor protein binding family B member 3","protein_coding",null,null,"GO:0001540,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0006355,GO:0008134,GO:0015629,GO:0016020,GO:0016604,GO:0050714,GO:0050750","amyloid-beta binding|protein binding|nucleus|cytoplasm|cytosol|regulation of DNA-templated transcription|transcription factor binding|actin cytoskeleton|membrane|nuclear body|positive regulation of protein secretion|low-density lipoprotein particle receptor binding"]
["APC",3.85829538691028,3.87836943201237,2.63319725777986,2.40962223650062,4.22847941892337,2.95251277397381,2.84549948104177,2.56080826501721,3.23607741128616,2.54242941206422,2.12124501611711,2.32858518467841,3.35764730870116,2.24704477018417,2.97883595561033,3.10180278089008,2.5153110590235,2.23094292310439,2.18921715148249,3.01214453931637,2.66283780822359,2.06112144928588,3.03881304007701,2.95891381228572,2.95127195705119,1.78936689184487,2.42900774946359,2.03409289449602,324,"APC regulator of WNT signaling pathway","protein_coding","hsa04310,hsa04390,hsa04550,hsa04810,hsa05200,hsa05206,hsa05210,hsa05225,hsa05226,hsa05217,hsa05213,hsa05224,hsa05165,hsa05010,hsa05022,hsa04934","Wnt signaling pathway|Hippo signaling pathway|Signaling pathways regulating pluripotency of stem cells|Regulation of actin cytoskeleton|Pathways in cancer|MicroRNAs in cancer|Colorectal cancer|Hepatocellular carcinoma|Gastric cancer|Basal cell carcinoma|Endometrial cancer|Breast cancer|Human papillomavirus infection|Alzheimer disease|Pathways of neurodegeneration - multiple diseases|Cushing syndrome","GO:0000281,GO:0000776,GO:0001708,GO:0003170,GO:0003203,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005794,GO:0005813,GO:0005829,GO:0005874,GO:0005881,GO:0005886,GO:0005912,GO:0005923,GO:0006974,GO:0007026,GO:0007094,GO:0007155,GO:0007389,GO:0007399,GO:0008013,GO:0008017,GO:0008285,GO:0016055,GO:0016328,GO:0016342,GO:0016477,GO:0019887,GO:0019901,GO:0030027,GO:0030335,GO:0030877,GO:0031274,GO:0031625,GO:0032587,GO:0032886,GO:0043065,GO:0043161,GO:0045295,GO:0045296,GO:0045595,GO:0045732,GO:0045736,GO:0048471,GO:0051010,GO:0051988,GO:0065003,GO:0070830,GO:0070840,GO:0090090,GO:0120162,GO:1902807,GO:1904781,GO:1990909,GO:2000134","mitotic cytokinesis|kinetochore|cell fate specification|heart valve development|endocardial cushion morphogenesis|protein binding|nucleus|nucleoplasm|cytoplasm|Golgi apparatus|centrosome|cytosol|microtubule|cytoplasmic microtubule|plasma membrane|adherens junction|bicellular tight junction|DNA damage response|negative regulation of microtubule depolymerization|mitotic spindle assembly checkpoint signaling|cell adhesion|pattern specification process|nervous system development|beta-catenin binding|microtubule binding|negative regulation of cell population proliferation|Wnt signaling pathway|lateral plasma membrane|catenin complex|cell migration|protein kinase regulator activity|protein kinase binding|lamellipodium|positive regulation of cell migration|beta-catenin destruction complex|positive regulation of pseudopodium assembly|ubiquitin protein ligase binding|ruffle membrane|regulation of microtubule-based process|positive regulation of apoptotic process|proteasome-mediated ubiquitin-dependent protein catabolic process|gamma-catenin binding|cadherin binding|regulation of cell differentiation|positive regulation of protein catabolic process|negative regulation of cyclin-dependent protein serine/threonine kinase activity|perinuclear region of cytoplasm|microtubule plus-end binding|regulation of attachment of spindle microtubules to kinetochore|protein-containing complex assembly|bicellular tight junction assembly|dynein complex binding|negative regulation of canonical Wnt signaling pathway|positive regulation of cold-induced thermogenesis|negative regulation of cell cycle G1/S phase transition|positive regulation of protein localization to centrosome|Wnt signalosome|negative regulation of G1/S transition of mitotic cell cycle","WP3664,WP5117,WP4216,WP428,WP5124,WP3286,WP4262,WP2853,WP5413,WP399,WP2870,WP2059,WP2038,WP4844,WP4258,WP51,WP363,WP2380,WP710,WP5223,WP4879,WP4352,WP2361,WP3680,WP3658,WP4336,WP4155,WP5087,WP3931","Regulation of Wnt / B-catenin signaling by small molecule compounds|Cohesin complex - Cornelia de Lange syndrome|Chromosomal and microsatellite instability in colorectal cancer |Wnt signaling|Alzheimer's disease|Copper homeostasis|Breast cancer pathway|Endoderm differentiation|IL-24 Signaling pathway|Wnt signaling pathway and pluripotency|Extracellular vesicle-mediated signaling in recipient cells|Alzheimer's disease and miRNA effects|Microtubule cytoskeleton regulation|Influence of laminopathies on Wnt signaling|lncRNA in canonical Wnt signaling and colorectal cancer|Regulation of actin cytoskeleton|Wnt signaling pathway|Brain-derived neurotrophic factor (BDNF) signaling pathway|DNA damage response (only ATM dependent)|2q21.1 copy number variation syndrome|Overlap between signal transduction pathways contributing to LMNA laminopathies|Ciliary landscape|Gastric cancer network 1|Physico-chemical features and toxicity-associated pathways|Wnt/beta-catenin signaling pathway in leukemia|ncRNAs involved in Wnt signaling in hepatocellular carcinoma|Endometrial cancer|Pleural mesothelioma|Embryonic stem cell pluripotency pathways","R-HSA-109581,R-HSA-111465,R-HSA-162582,R-HSA-162582,R-HSA-1643685,R-HSA-195253,R-HSA-195721,R-HSA-195721,R-HSA-196299,R-HSA-201681,R-HSA-201681,R-HSA-3769402,R-HSA-392499,R-HSA-4641262,R-HSA-4641262,R-HSA-4791275,R-HSA-4839735,R-HSA-4839743,R-HSA-4839744,R-HSA-4839748,R-HSA-5339716,R-HSA-5357801,R-HSA-5358747,R-HSA-5358749,R-HSA-5358751,R-HSA-5358752,R-HSA-5467333,R-HSA-5467337,R-HSA-5467340,R-HSA-5467348,R-HSA-5663202,R-HSA-5688426,R-HSA-5689896,R-HSA-597592,R-HSA-75153","Apoptosis|Apoptotic cleavage of cellular proteins|Signal Transduction|Signal Transduction|Disease|Degradation of beta-catenin by the destruction complex|Signaling by WNT|Signaling by WNT|Beta-catenin phosphorylation cascade|TCF dependent signaling in response to WNT|TCF dependent signaling in response to WNT|Deactivation of the beta-catenin transactivating complex|Metabolism of proteins|Disassembly of the destruction complex and recruitment of AXIN to the membrane|Disassembly of the destruction complex and recruitment of AXIN to the membrane|Signaling by WNT in cancer|Signaling by AXIN mutants|Signaling by CTNNB1 phospho-site mutants|Signaling by APC mutants|Signaling by AMER1 mutants|Signaling by GSK3beta mutants|Programmed Cell Death|CTNNB1 S33 mutants aren't phosphorylated|CTNNB1 S37 mutants aren't phosphorylated|CTNNB1 S45 mutants aren't phosphorylated|CTNNB1 T41 mutants aren't phosphorylated|APC truncation mutants are not K63 polyubiquitinated|APC truncation mutants have impaired AXIN binding|AXIN missense mutants destabilize the destruction complex|Truncations of AMER1 destabilize the destruction complex|Diseases of signal transduction by growth factor receptors and second messengers|Deubiquitination|Ovarian tumor domain proteases|Post-translational protein modification|Apoptotic execution phase","other"]
["APC2",0.151151558532536,0.107218461760425,0.0745610388281359,0.132678129770297,0.0901213873345233,0.115475809847764,0.112340387090602,0.0929507396827028,0.108230425198133,0.148045753722363,0.0891444777221776,0.18815567685292,0.0828354055275194,0.124564911886182,0.0786239564212708,0.150601822687997,0.0911348051132606,0.0616311110844949,0.049722836850873,0.0886884676659281,0.0604511262567121,0.0998420376596848,0.0682870563887246,0.122641962424069,0.139695492707711,0.102238797352094,0.061977367408629,0.0746626876051467,10297,"APC regulator of WNT signaling pathway 2","protein_coding","hsa04310,hsa04390,hsa04550,hsa04810,hsa05200,hsa05206,hsa05210,hsa05225,hsa05226,hsa05217,hsa05213,hsa05224,hsa05165,hsa05010,hsa05022,hsa04934","Wnt signaling pathway|Hippo signaling pathway|Signaling pathways regulating pluripotency of stem cells|Regulation of actin cytoskeleton|Pathways in cancer|MicroRNAs in cancer|Colorectal cancer|Hepatocellular carcinoma|Gastric cancer|Basal cell carcinoma|Endometrial cancer|Breast cancer|Human papillomavirus infection|Alzheimer disease|Pathways of neurodegeneration - multiple diseases|Cushing syndrome","GO:0000226,GO:0001708,GO:0005515,GO:0005737,GO:0005794,GO:0005829,GO:0005881,GO:0005884,GO:0007026,GO:0007389,GO:0007399,GO:0008013,GO:0008017,GO:0015630,GO:0016055,GO:0016342,GO:0016477,GO:0030496,GO:0030877,GO:0031258,GO:0043161,GO:0045171,GO:0045295,GO:0045595,GO:0045732,GO:0048471,GO:0090090,GO:0090630,GO:0098794","microtubule cytoskeleton organization|cell fate specification|protein binding|cytoplasm|Golgi apparatus|cytosol|cytoplasmic microtubule|actin filament|negative regulation of microtubule depolymerization|pattern specification process|nervous system development|beta-catenin binding|microtubule binding|microtubule cytoskeleton|Wnt signaling pathway|catenin complex|cell migration|midbody|beta-catenin destruction complex|lamellipodium membrane|proteasome-mediated ubiquitin-dependent protein catabolic process|intercellular bridge|gamma-catenin binding|regulation of cell differentiation|positive regulation of protein catabolic process|perinuclear region of cytoplasm|negative regulation of canonical Wnt signaling pathway|activation of GTPase activity|postsynapse","WP4216,WP5124,WP4262,WP2059,WP4258,WP51,WP4155","Chromosomal and microsatellite instability in colorectal cancer |Alzheimer's disease|Breast cancer pathway|Alzheimer's disease and miRNA effects|lncRNA in canonical Wnt signaling and colorectal cancer|Regulation of actin cytoskeleton|Endometrial cancer"]
["APCDD1",4.61888674873432,5.52792521218375,5.82956234642773,5.39879585614532,5.05094249354318,6.16591931894285,6.09817871463733,5.55743067996552,7.83734166495242,9.45585539419322,8.35975825624272,7.60340810288758,7.7516588375636,8.8434360709888,9.45727713643056,8.94989509654588,12.222618049421,12.4380600234005,11.7243003635581,12.7146594589009,13.2842714344114,12.534447978837,11.0608821075839,11.5021517928801,11.7883842533205,12.3071965284315,10.6126928175832,12.3355798482983,147495,"APC down-regulated 1","protein_coding","hsa04310","Wnt signaling pathway","GO:0001942,GO:0005515,GO:0005886,GO:0016055,GO:0017147,GO:0030178,GO:0042487,GO:0042802,GO:0043615","hair follicle development|protein binding|plasma membrane|Wnt signaling pathway|Wnt-protein binding|negative regulation of Wnt signaling pathway|regulation of odontogenesis of dentin-containing tooth|identical protein binding|astrocyte cell migration"]
["APCDD1L",37.5248052892775,36.9875758338256,23.941680081242,33.1279971136299,31.5397699823188,28.968649233701,19.9625049867755,26.7458451517681,19.8980731186939,27.2610446421095,19.5784347358816,20.8915034180814,17.037437939456,12.9320549573015,11.5028878514801,13.3146506612786,11.2531654455386,12.2864296462,12.1190898961112,13.3441017647944,11.1413564868481,12.8493230338105,9.86955070934279,10.8898330666283,10.971877651932,11.5063972911926,9.05712505235974,11.9153430456479,164284,"APC down-regulated 1 like","protein_coding","hsa04310","Wnt signaling pathway","GO:0005515,GO:0005886,GO:0017147,GO:0030178","protein binding|plasma membrane|Wnt-protein binding|negative regulation of Wnt signaling pathway"]
["APCDD1L-DT",6.03171037467987,4.8074686987636,4.17766271685203,5.04470654960255,5.17761320324358,4.35977423375638,4.06766122356588,4.28782510057865,1.79813334034137,2.06856034710034,1.74165540568078,2.26432902575764,1.60219510470691,1.44682023965571,1.53093919863911,1.29256211602937,1.52087904356319,1.6421497360299,1.40257350378718,1.81797959535082,1.74796969595668,1.4791832101899,1.79019673155966,1.97264839143841,1.55555923717042,1.89410983494075,1.69254039967192,2.11586031491222,149773,"APCDD1L divergent transcript","non_coding"]
["APEH",24.5097257555893,23.0752405872071,26.4438602374124,26.9766044723298,21.9284955539625,24.80206307567,27.6595181788049,25.6167602159976,22.2634866628118,26.2460312225264,26.0434057869498,23.3185972044647,20.7565917485052,22.7808628694561,23.0797995577685,21.6540556760099,26.7357108708,27.3178770704823,32.4189329729031,26.7900348921418,26.9961901412495,27.2056624632495,27.6865565645375,27.2865399970821,24.5090445179563,27.931772687443,31.1235549373741,30.0623455829206,327,"acylaminoacyl-peptide hydrolase","protein_coding",null,null,"GO:0003723,GO:0004252,GO:0005515,GO:0005576,GO:0005829,GO:0006415,GO:0006508,GO:0008242,GO:0031965,GO:0042802,GO:0050435,GO:0070062,GO:1904813","RNA binding|serine-type endopeptidase activity|protein binding|extracellular region|cytosol|translational termination|proteolysis|omega peptidase activity|nuclear membrane|identical protein binding|amyloid-beta metabolic process|extracellular exosome|ficolin-1-rich granule lumen",null,null,"R-HSA-168249,R-HSA-168256,R-HSA-392499,R-HSA-6798695,R-HSA-72764,R-HSA-72766","Innate Immune System|Immune System|Metabolism of proteins|Neutrophil degranulation|Eukaryotic Translation Termination|Translation"]
["APELA",0,0,0,0,0,0,0,0,0,0,0.0260007815548926,0.0649030241092377,0.052584864974996,0,0.0428532126114795,0.104855740501115,0,0,0.0340697559198948,0,0,0,0.00909802351784946,0.00900358436159815,0,0,0.00891796047690386,0,100506013,"apelin receptor early endogenous ligand","protein_coding","hsa04371,hsa04080","Apelin signaling pathway|Neuroactive ligand-receptor interaction","GO:0001525,GO:0001570,GO:0005179,GO:0005576,GO:0005615,GO:0007492,GO:0007507,GO:0007509,GO:0007512,GO:0031704,GO:0035050,GO:0045766,GO:0045823,GO:0060183,GO:0060674,GO:0060976,GO:0070374,GO:0090133,GO:0090134,GO:1901165,GO:1903589,GO:1904022","angiogenesis|vasculogenesis|hormone activity|extracellular region|extracellular space|endoderm development|heart development|mesoderm migration involved in gastrulation|adult heart development|apelin receptor binding|embryonic heart tube development|positive regulation of angiogenesis|positive regulation of heart contraction|apelin receptor signaling pathway|placenta blood vessel development|coronary vasculature development|positive regulation of ERK1 and ERK2 cascade|mesendoderm migration|cell migration involved in mesendoderm migration|positive regulation of trophoblast cell migration|positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis|positive regulation of G protein-coupled receptor internalization"]
["APEX1",118.900470366602,118.917298686736,147.943264040332,140.258694089058,109.114481775565,125.451330999686,153.807336013056,142.389886244346,132.305833343123,129.471958593151,156.675734964805,143.14160640932,127.99917945931,137.50002227013,149.983442312788,133.052408916324,120.237394155373,127.815158914925,142.759722003261,118.797239391756,120.664445354722,121.201670654726,135.73258633898,124.536209452499,120.805172983906,136.68627922489,146.761979476025,133.442082299277,328,"apurinic/apyrimidinic endodeoxyribonuclease 1","protein_coding","hsa03410","Base excision repair","GO:0000723,GO:0000781,GO:0003677,GO:0003684,GO:0003691,GO:0003713,GO:0003714,GO:0003723,GO:0003906,GO:0004519,GO:0004520,GO:0004523,GO:0004528,GO:0004844,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005739,GO:0005783,GO:0005813,GO:0005840,GO:0006281,GO:0006284,GO:0006287,GO:0006308,GO:0006310,GO:0008081,GO:0008296,GO:0008309,GO:0008311,GO:0008408,GO:0016491,GO:0016607,GO:0016890,GO:0031490,GO:0042981,GO:0043488,GO:0045454,GO:0045892,GO:0045944,GO:0046872,GO:0048471,GO:0052720,GO:0080111,GO:0090580,GO:0097698,GO:0140431","telomere maintenance|chromosome, telomeric region|DNA binding|damaged DNA binding|double-stranded telomeric DNA binding|transcription coactivator activity|transcription corepressor activity|RNA binding|DNA-(apurinic or apyrimidinic site) endonuclease activity|endonuclease activity|DNA endonuclease activity|RNA-DNA hybrid ribonuclease activity|phosphodiesterase I activity|uracil DNA N-glycosylase activity|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|mitochondrion|endoplasmic reticulum|centrosome|ribosome|DNA repair|base-excision repair|base-excision repair, gap-filling|DNA catabolic process|DNA recombination|phosphoric diester hydrolase activity|3'-5'-DNA exonuclease activity|double-stranded DNA exodeoxyribonuclease activity|double-stranded DNA 3'-5' DNA exonuclease activity|3'-5' exonuclease activity|oxidoreductase activity|nuclear speck|site-specific endodeoxyribonuclease activity, specific for altered base|chromatin DNA binding|regulation of apoptotic process|regulation of mRNA stability|cell redox homeostasis|negative regulation of DNA-templated transcription|positive regulation of transcription by RNA polymerase II|metal ion binding|perinuclear region of cytoplasm|class II DNA-(apurinic or apyrimidinic site) endonuclease activity|DNA demethylation|phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands|telomere maintenance via base-excision repair|DNA-(abasic site) binding","WP2032,WP4946,WP4752,WP2431","Thyroid stimulating hormone (TSH) signaling pathway|DNA repair pathways, full network|Base excision repair|Spinal cord injury","R-HSA-110357,R-HSA-110362,R-HSA-110373,R-HSA-110381,R-HSA-5651801,R-HSA-73884,R-HSA-73894,R-HSA-73930,R-HSA-73933","Displacement of DNA glycosylase by APEX1|POLB-Dependent Long Patch Base Excision Repair|Resolution of AP sites via the multiple-nucleotide patch replacement pathway|Resolution of AP sites via the single-nucleotide replacement pathway|PCNA-Dependent Long Patch Base Excision Repair|Base Excision Repair|DNA Repair|Abasic sugar-phosphate removal via the single-nucleotide replacement pathway|Resolution of Abasic Sites (AP sites)"]
["APEX2",6.94919410973386,6.88689557340633,6.03191073931945,7.46284706156032,5.36730967010003,6.08018404991086,5.94777015215471,5.98194547529723,6.06911588749249,7.52657938667302,6.99709207851874,6.53932390291295,4.98614592634938,5.66514604511571,5.41010232634243,4.71086023094989,5.68104518224032,7.77741677558797,7.19176626438889,5.89019692112396,6.24480477463581,6.66875102052829,5.81694871970189,5.65086803306077,5.66019208144821,6.89557166118422,5.90315844751275,7.44845542361988,27301,"apurinic/apyrimidinic endodeoxyribonuclease 2","protein_coding",null,null,"GO:0001650,GO:0003677,GO:0003906,GO:0004519,GO:0005515,GO:0005634,GO:0005654,GO:0005739,GO:0006284,GO:0006310,GO:0007049,GO:0008081,GO:0008270,GO:0008311,GO:0043231","fibrillar center|DNA binding|DNA-(apurinic or apyrimidinic site) endonuclease activity|endonuclease activity|protein binding|nucleus|nucleoplasm|mitochondrion|base-excision repair|DNA recombination|cell cycle|phosphoric diester hydrolase activity|zinc ion binding|double-stranded DNA 3'-5' DNA exonuclease activity|intracellular membrane-bounded organelle","WP4946,WP4752","DNA repair pathways, full network|Base excision repair"]
["APH1A",49.1472069800273,43.4943996519913,48.8429586074851,48.0132131072082,46.6367992424699,48.0557102315277,52.5837883070828,54.3323261964729,55.2248241099337,57.46800212812,55.0071993831152,57.1545125406627,52.9229756319409,55.754892214231,56.0297213960172,53.2610826772433,68.8029555688588,62.306542378875,72.7198126264468,58.2226725201252,68.4615068828128,63.4665763042117,70.7401287342403,68.8465241841878,67.9009982127182,65.6977719771119,80.5607128107276,69.806782014925,51107,"aph-1 homolog A%2C gamma-secretase subunit","protein_coding","hsa04330,hsa05010","Notch signaling pathway|Alzheimer disease","GO:0000139,GO:0001656,GO:0005515,GO:0005769,GO:0005783,GO:0005789,GO:0005794,GO:0005886,GO:0006509,GO:0007219,GO:0007220,GO:0008021,GO:0010008,GO:0010950,GO:0016020,GO:0016485,GO:0019899,GO:0030674,GO:0031293,GO:0032580,GO:0034205,GO:0042734,GO:0042982,GO:0042987,GO:0043085,GO:0061133,GO:0070765","Golgi membrane|metanephros development|protein binding|early endosome|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|plasma membrane|membrane protein ectodomain proteolysis|Notch signaling pathway|Notch receptor processing|synaptic vesicle|endosome membrane|positive regulation of endopeptidase activity|membrane|protein processing|enzyme binding|protein-macromolecule adaptor activity|membrane protein intracellular domain proteolysis|Golgi cisterna membrane|amyloid-beta formation|presynaptic membrane|amyloid precursor protein metabolic process|amyloid precursor protein catabolic process|positive regulation of catalytic activity|endopeptidase activator activity|gamma-secretase complex","WP5124,WP61,WP2059,WP268,WP5180","Alzheimer's disease|Notch signaling pathway|Alzheimer's disease and miRNA effects|Notch signaling|DYRK1A involvement regarding cell proliferation in brain development","R-HSA-1236394,R-HSA-1251985,R-HSA-1266738,R-HSA-157118,R-HSA-157118,R-HSA-162582,R-HSA-162582,R-HSA-1643685,R-HSA-193692,R-HSA-193704,R-HSA-1980143,R-HSA-1980145,R-HSA-204998,R-HSA-205043,R-HSA-2122948,R-HSA-2644602,R-HSA-2644603,R-HSA-2644606,R-HSA-2682334,R-HSA-2894858,R-HSA-2894862,R-HSA-2979096,R-HSA-392499,R-HSA-3928665,R-HSA-422475,R-HSA-5663202,R-HSA-73887,R-HSA-9006934,R-HSA-9012852,R-HSA-9013507,R-HSA-9013694,R-HSA-9013700,R-HSA-9017802,R-HSA-9675108,R-HSA-977225","Signaling by ERBB4|Nuclear signaling by ERBB4|Developmental Biology|Signaling by NOTCH|Signaling by NOTCH|Signal Transduction|Signal Transduction|Disease|Regulated proteolysis of p75NTR|p75 NTR receptor-mediated signalling|Signaling by NOTCH1|Signaling by NOTCH2|Cell death signalling via NRAGE, NRIF and NADE|NRIF signals cell death from the nucleus|Activated NOTCH1 Transmits Signal to the Nucleus|Signaling by NOTCH1 PEST Domain Mutants in Cancer|Signaling by NOTCH1 in Cancer|Constitutive Signaling by NOTCH1 PEST Domain Mutants|EPH-Ephrin signaling|Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer|Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants|NOTCH2 Activation and Transmission of Signal to the Nucleus|Metabolism of proteins|EPH-ephrin mediated repulsion of cells|Axon guidance|Diseases of signal transduction by growth factor receptors and second messengers|Death Receptor Signaling|Signaling by Receptor Tyrosine Kinases|Signaling by NOTCH3|NOTCH3 Activation and Transmission of Signal to the Nucleus|Signaling by NOTCH4|NOTCH4 Activation and Transmission of Signal to the Nucleus|Noncanonical activation of NOTCH3|Nervous system development|Amyloid fiber formation"]
["APH1B",8.99657400952489,8.02605919904073,8.35193356005257,7.42317689877193,9.27128102669025,8.11261921213366,7.70596852297436,8.02797654629696,7.52145133494455,4.21678799047958,4.9052437793584,5.7195681949413,7.18017081106689,6.56462049474275,5.96216294294953,7.39171060679865,6.09932640406924,6.12302451542446,6.39998988613314,6.5247207201896,6.11425258378973,6.44951200872163,6.86931875118671,6.01782455691217,6.37812728538209,6.20830868090366,5.73903180597272,5.84329871132305,83464,"aph-1 homolog B%2C gamma-secretase subunit","protein_coding","hsa04330,hsa05010","Notch signaling pathway|Alzheimer disease","GO:0000139,GO:0005515,GO:0005783,GO:0005789,GO:0005886,GO:0007219,GO:0007220,GO:0010008,GO:0010950,GO:0016020,GO:0016485,GO:0030133,GO:0030674,GO:0031293,GO:0034205,GO:0042987,GO:0061133,GO:0070765","Golgi membrane|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|plasma membrane|Notch signaling pathway|Notch receptor processing|endosome membrane|positive regulation of endopeptidase activity|membrane|protein processing|transport vesicle|protein-macromolecule adaptor activity|membrane protein intracellular domain proteolysis|amyloid-beta formation|amyloid precursor protein catabolic process|endopeptidase activator activity|gamma-secretase complex","WP5124,WP61,WP2059,WP268","Alzheimer's disease|Notch signaling pathway|Alzheimer's disease and miRNA effects|Notch signaling","R-HSA-1236394,R-HSA-1251985,R-HSA-1266738,R-HSA-157118,R-HSA-157118,R-HSA-162582,R-HSA-162582,R-HSA-1643685,R-HSA-193692,R-HSA-193704,R-HSA-1980143,R-HSA-1980145,R-HSA-204998,R-HSA-205043,R-HSA-2122948,R-HSA-2644602,R-HSA-2644603,R-HSA-2644606,R-HSA-2682334,R-HSA-2894858,R-HSA-2894862,R-HSA-2979096,R-HSA-392499,R-HSA-3928665,R-HSA-422475,R-HSA-5663202,R-HSA-73887,R-HSA-9006934,R-HSA-9012852,R-HSA-9013507,R-HSA-9013694,R-HSA-9013700,R-HSA-9017802,R-HSA-9675108,R-HSA-977225","Signaling by ERBB4|Nuclear signaling by ERBB4|Developmental Biology|Signaling by NOTCH|Signaling by NOTCH|Signal Transduction|Signal Transduction|Disease|Regulated proteolysis of p75NTR|p75 NTR receptor-mediated signalling|Signaling by NOTCH1|Signaling by NOTCH2|Cell death signalling via NRAGE, NRIF and NADE|NRIF signals cell death from the nucleus|Activated NOTCH1 Transmits Signal to the Nucleus|Signaling by NOTCH1 PEST Domain Mutants in Cancer|Signaling by NOTCH1 in Cancer|Constitutive Signaling by NOTCH1 PEST Domain Mutants|EPH-Ephrin signaling|Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer|Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants|NOTCH2 Activation and Transmission of Signal to the Nucleus|Metabolism of proteins|EPH-ephrin mediated repulsion of cells|Axon guidance|Diseases of signal transduction by growth factor receptors and second messengers|Death Receptor Signaling|Signaling by Receptor Tyrosine Kinases|Signaling by NOTCH3|NOTCH3 Activation and Transmission of Signal to the Nucleus|Signaling by NOTCH4|NOTCH4 Activation and Transmission of Signal to the Nucleus|Noncanonical activation of NOTCH3|Nervous system development|Amyloid fiber formation"]
["API5",17.6897756363813,15.2147252734363,16.860796840599,13.284430201509,17.123944528762,15.0353966836749,15.8004047096065,14.9153808382989,18.7964588067332,11.739019027494,14.8476828088688,16.317819167457,19.2611218414465,15.3014869139631,18.8967244866584,17.7362429312177,14.4278151988541,14.4940758647615,15.0648096508905,18.673078352228,16.2314205904795,15.7169741310709,20.6790005619552,18.1775771804257,16.0189801979005,14.4417484746417,16.7790623985756,13.5540766794057,8539,"apoptosis inhibitor 5","protein_coding",null,null,"GO:0003723,GO:0005515,GO:0005634,GO:0005681,GO:0005737,GO:0016020,GO:0016607,GO:0017134,GO:0043066,GO:0044346,GO:2000270","RNA binding|protein binding|nucleus|spliceosomal complex|cytoplasm|membrane|nuclear speck|fibroblast growth factor binding|negative regulation of apoptotic process|fibroblast apoptotic process|negative regulation of fibroblast apoptotic process"]
["APIP",14.6710180672657,13.378776827911,15.8464146572008,13.8313006747992,13.953146640653,12.5897520754525,15.0002407927357,13.0245394600714,9.52761344991656,6.82496139834157,10.1470024978258,10.5328091305414,10.9719675334222,9.01347985497534,11.8556780940847,8.84590452807462,17.2379032157081,14.9583923421044,19.335120934146,16.3679754565267,18.4518174906074,15.0454008297657,22.5689874015767,20.2473604200351,18.711042785238,15.6826192372744,22.9320877012352,16.3032168195303,51074,"APAF1 interacting protein","protein_coding","hsa00270","Cysteine and methionine metabolism","GO:0005515,GO:0005737,GO:0005829,GO:0006915,GO:0008270,GO:0019284,GO:0019509,GO:0042802,GO:0043066,GO:0046570,GO:0051289,GO:0070269,GO:0070372","protein binding|cytoplasm|cytosol|apoptotic process|zinc ion binding|L-methionine salvage from S-adenosylmethionine|L-methionine salvage from methylthioadenosine|identical protein binding|negative regulation of apoptotic process|methylthioribulose 1-phosphate dehydratase activity|protein homotetramerization|pyroptosis|regulation of ERK1 and ERK2 cascade","WP3580","Methionine de novo and salvage pathway","R-HSA-109581,R-HSA-109606,R-HSA-111458,R-HSA-111461,R-HSA-111471,R-HSA-1237112,R-HSA-1430728,R-HSA-1614635,R-HSA-5357801,R-HSA-71291,R-HSA-9627069","Apoptosis|Intrinsic Pathway for Apoptosis|Formation of apoptosome|Cytochrome c-mediated apoptotic response|Apoptotic factor-mediated response|Methionine salvage pathway|Metabolism|Sulfur amino acid metabolism|Programmed Cell Death|Metabolism of amino acids and derivatives|Regulation of the apoptosome activity"]
["APLF",0.824974413424913,0.798101002916199,0.887051948509046,0.62890135328182,0.840580281477099,0.97995355818015,0.743379363902179,0.725996328826568,0.687964150515502,0.502539755555567,0.815627446500262,0.666831825374049,0.757721357392125,0.631898612984582,0.596727903053129,0.588322164203224,0.725371223080677,0.528452148104745,0.788525919693225,0.867897864300539,0.632240034474987,0.844489246423481,0.730899940601495,0.991972203271028,0.859842317243843,0.844172084022027,0.921129909316613,0.841859555243998,200558,"aprataxin and PNKP like factor","protein_coding",null,null,"GO:0000012,GO:0000166,GO:0003906,GO:0004520,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006281,GO:0006302,GO:0006303,GO:0006457,GO:0006974,GO:0007566,GO:0008408,GO:0010717,GO:0035861,GO:0042393,GO:0044183,GO:0045191,GO:0046872,GO:0051106,GO:0071168,GO:0072572,GO:0090734,GO:0140713,GO:0140861,GO:0160002","single strand break repair|nucleotide binding|DNA-(apurinic or apyrimidinic site) endonuclease activity|DNA endonuclease activity|protein binding|nucleus|nucleoplasm|cytosol|DNA repair|double-strand break repair|double-strand break repair via nonhomologous end joining|protein folding|DNA damage response|embryo implantation|3'-5' exonuclease activity|regulation of epithelial to mesenchymal transition|site of double-strand break|histone binding|protein folding chaperone|regulation of isotype switching|metal ion binding|positive regulation of DNA ligation|protein localization to chromatin|poly-ADP-D-ribose binding|site of DNA damage|histone chaperone activity|DNA repair-dependent chromatin remodeling|ADP-D-ribose modification-dependent protein binding"]
["APLN",0.92808309277667,0.556696127234825,0.730022875821631,0.641503208088902,0.620929401473092,0.793002246129523,0.421245313474971,0.688705698536965,0.386866540832145,0.555644551416473,0.574009189568699,0.479482306567381,0.469129087730559,0.199282343646063,0.349910304589701,0.269538445844601,0.731521680014395,0.727206525316367,0.81911661158215,0.70753933171973,0.702356585510027,0.802701763797249,0.676848927033558,0.571800216512785,0.638283611655942,0.826233967541273,0.606816867128035,1.2733863907286,8862,"apelin","protein_coding","hsa04371,hsa04080","Apelin signaling pathway|Neuroactive ligand-receptor interaction","GO:0001525,GO:0005102,GO:0005179,GO:0005576,GO:0005615,GO:0006955,GO:0007165,GO:0007369,GO:0007595,GO:0010629,GO:0031704,GO:0040037,GO:0042756,GO:0045776,GO:0045823,GO:0060183,GO:0060976,GO:1902895,GO:1904022,GO:1904706,GO:1905564","angiogenesis|signaling receptor binding|hormone activity|extracellular region|extracellular space|immune response|signal transduction|gastrulation|lactation|negative regulation of gene expression|apelin receptor binding|negative regulation of fibroblast growth factor receptor signaling pathway|drinking behavior|negative regulation of blood pressure|positive regulation of heart contraction|apelin receptor signaling pathway|coronary vasculature development|positive regulation of miRNA transcription|positive regulation of G protein-coupled receptor internalization|negative regulation of vascular associated smooth muscle cell proliferation|positive regulation of vascular endothelial cell proliferation",null,null,"R-HSA-162582,R-HSA-372790,R-HSA-373076,R-HSA-375276,R-HSA-388396,R-HSA-418594,R-HSA-500792","Signal Transduction|Signaling by GPCR|Class A/1 (Rhodopsin-like receptors)|Peptide ligand-binding receptors|GPCR downstream signalling|G alpha (i) signalling events|GPCR ligand binding"]
["APLP1",5.08051511375217,3.91554875927906,3.03433992979289,5.20966995287579,6.63775633715209,4.54722841475741,2.63455045864054,4.57048263981302,6.78712981240043,7.90774009649904,6.10039372030443,6.83424280102126,5.85606692035912,6.33566609484453,4.15533738949091,5.94610789700136,10.2271470215559,10.4614268660975,6.02661661104051,9.31304361813309,10.0507644710856,9.91714178186059,5.32906106180134,7.15722458159772,8.9832937120294,10.2366808347036,5.20164337534849,9.44593086836864,333,"amyloid beta precursor like protein 1","protein_coding",null,null,"GO:0005515,GO:0005604,GO:0005654,GO:0005794,GO:0005886,GO:0006417,GO:0006897,GO:0006915,GO:0007155,GO:0007399,GO:0007409,GO:0007417,GO:0008201,GO:0009887,GO:0030198,GO:0030900,GO:0031694,GO:0031695,GO:0031696,GO:0042802,GO:0046914,GO:0048471,GO:0071874,GO:0106072,GO:0180011","protein binding|basement membrane|nucleoplasm|Golgi apparatus|plasma membrane|regulation of translation|endocytosis|apoptotic process|cell adhesion|nervous system development|axonogenesis|central nervous system development|heparin binding|animal organ morphogenesis|extracellular matrix organization|forebrain development|alpha-2A adrenergic receptor binding|alpha-2B adrenergic receptor binding|alpha-2C adrenergic receptor binding|identical protein binding|transition metal ion binding|perinuclear region of cytoplasm|cellular response to norepinephrine stimulus|negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway|cytoplasmic polyadenylation","WP5323","Fatty Acids and Lipoproteins Transport in Hepatocytes"]
["APLP2",192.728703835684,188.34963924348,188.117924689151,175.340775142023,208.182323059788,203.330950546694,198.875053737043,199.285186069704,167.614407944209,155.172273527631,146.031489851449,157.515291558129,176.815771779325,173.608689729145,176.66460547468,185.462423129818,168.887859686698,171.384855568316,160.853233748856,168.134486639112,153.355563993907,156.61395936247,142.970239719766,154.338810491769,160.908011440003,149.323699989192,142.371958348574,144.277566089777,334,"amyloid beta precursor like protein 2","protein_coding",null,null,"GO:0003677,GO:0004867,GO:0005515,GO:0005634,GO:0005788,GO:0005886,GO:0007186,GO:0007409,GO:0007417,GO:0008201,GO:0016020,GO:0031092,GO:0042802,GO:0046914,GO:0070062","DNA binding|serine-type endopeptidase inhibitor activity|protein binding|nucleus|endoplasmic reticulum lumen|plasma membrane|G protein-coupled receptor signaling pathway|axonogenesis|central nervous system development|heparin binding|membrane|platelet alpha granule membrane|identical protein binding|transition metal ion binding|extracellular exosome","WP4148","Splicing factor NOVA regulated synaptic proteins","R-HSA-109582,R-HSA-114608,R-HSA-381426,R-HSA-392499,R-HSA-597592,R-HSA-76002,R-HSA-76005,R-HSA-8957275","Hemostasis|Platelet degranulation |Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)|Metabolism of proteins|Post-translational protein modification|Platelet activation, signaling and aggregation|Response to elevated platelet cytosolic Ca2+|Post-translational protein phosphorylation"]
["APMAP",59.7542645995855,53.0241654715653,55.2597576459824,55.8202898400829,56.2542355319852,54.7089605285659,58.6866334749966,60.9484089055051,62.9402467056403,57.9217498150744,56.7277866532366,59.4571202743083,64.577681565944,67.8590712587489,60.7513131076936,61.0894234262969,78.5557813185723,76.5847563907512,79.4490860821927,72.7026041717161,70.6859563944515,73.876961130822,69.4072968013847,77.4026538577097,75.5394242819346,73.2898331149178,72.4925126381113,71.406643459185,57136,"adipocyte plasma membrane associated protein","protein_coding",null,null,"GO:0004064,GO:0005515,GO:0008150,GO:0009058,GO:0009986,GO:0016020,GO:0016844","arylesterase activity|protein binding|biological_process|biosynthetic process|cell surface|membrane|strictosidine synthase activity","WP4352","Ciliary landscape"]
["APOA1",0,0,0.0582226833477374,0.0198255976119499,0.0403995073932283,0.0388240181243027,0,0.0202708440337713,0.0415863472807027,0.059729195577711,0.0194407684171935,0.0415953868360036,0,0,0.0192247924675732,0,0.0198748221563946,0.0191270219098352,0.0764218067988439,0.0198785799416516,0,0,0.102038799040297,0.302938852657299,0.0819785819448155,0.0392841303585574,0,0.0194340193692201,335,"apolipoprotein A1","protein_coding","hsa03320,hsa04975,hsa04979,hsa04977,hsa05143,hsa05417","PPAR signaling pathway|Fat digestion and absorption|Cholesterol metabolism|Vitamin digestion and absorption|African trypanosomiasis|Lipid and atherosclerosis","GO:0001540,GO:0001932,GO:0001935,GO:0002719,GO:0005102,GO:0005515,GO:0005543,GO:0005576,GO:0005615,GO:0005769,GO:0005788,GO:0005829,GO:0005886,GO:0006656,GO:0006695,GO:0007179,GO:0007186,GO:0007229,GO:0008035,GO:0008203,GO:0008211,GO:0010804,GO:0010875,GO:0010903,GO:0015485,GO:0018158,GO:0018206,GO:0019899,GO:0019915,GO:0030139,GO:0030300,GO:0030301,GO:0030325,GO:0031072,GO:0031410,GO:0032489,GO:0032691,GO:0033344,GO:0033700,GO:0034115,GO:0034190,GO:0034191,GO:0034361,GO:0034364,GO:0034366,GO:0034375,GO:0034380,GO:0034384,GO:0034774,GO:0035025,GO:0042158,GO:0042632,GO:0042802,GO:0042803,GO:0043534,GO:0043691,GO:0045499,GO:0046470,GO:0050728,GO:0050766,GO:0050821,GO:0050919,GO:0051180,GO:0051345,GO:0051496,GO:0055091,GO:0060228,GO:0060354,GO:0060761,GO:0062023,GO:0070062,GO:0070328,GO:0070371,GO:0070508,GO:0070653,GO:0071682,GO:0072562,GO:0090205,GO:0120009,GO:0120020,GO:1900026,GO:1902995,GO:1903561,GO:1905920","amyloid-beta binding|regulation of protein phosphorylation|endothelial cell proliferation|negative regulation of cytokine production involved in immune response|signaling receptor binding|protein binding|phospholipid binding|extracellular region|extracellular space|early endosome|endoplasmic reticulum lumen|cytosol|plasma membrane|phosphatidylcholine biosynthetic process|cholesterol biosynthetic process|transforming growth factor beta receptor signaling pathway|G protein-coupled receptor signaling pathway|integrin-mediated signaling pathway|high-density lipoprotein particle binding|cholesterol metabolic process|glucocorticoid metabolic process|negative regulation of tumor necrosis factor-mediated signaling pathway|positive regulation of cholesterol efflux|negative regulation of very-low-density lipoprotein particle remodeling|cholesterol binding|protein oxidation|peptidyl-methionine modification|enzyme binding|lipid storage|endocytic vesicle|regulation of intestinal cholesterol absorption|cholesterol transport|adrenal gland development|heat shock protein binding|cytoplasmic vesicle|regulation of Cdc42 protein signal transduction|negative regulation of interleukin-1 beta production|cholesterol efflux|phospholipid efflux|negative regulation of heterotypic cell-cell adhesion|apolipoprotein receptor binding|apolipoprotein A-I receptor binding|very-low-density lipoprotein particle|high-density lipoprotein particle|spherical high-density lipoprotein particle|high-density lipoprotein particle remodeling|high-density lipoprotein particle assembly|high-density lipoprotein particle clearance|secretory granule lumen|positive regulation of Rho protein signal transduction|lipoprotein biosynthetic process|cholesterol homeostasis|identical protein binding|protein homodimerization activity|blood vessel endothelial cell migration|reverse cholesterol transport|chemorepellent activity|phosphatidylcholine metabolic process|negative regulation of inflammatory response|positive regulation of phagocytosis|protein stabilization|negative chemotaxis|vitamin transport|positive regulation of hydrolase activity|positive regulation of stress fiber assembly|phospholipid homeostasis|phosphatidylcholine-sterol O-acyltransferase activator activity|negative regulation of cell adhesion molecule production|negative regulation of response to cytokine stimulus|collagen-containing extracellular matrix|extracellular exosome|triglyceride homeostasis|ERK1 and ERK2 cascade|cholesterol import|high-density lipoprotein particle receptor binding|endocytic vesicle lumen|blood microparticle|positive regulation of cholesterol metabolic process|intermembrane lipid transfer|cholesterol transfer activity|positive regulation of substrate adhesion-dependent cell spreading|positive regulation of phospholipid efflux|extracellular vesicle|positive regulation of CoA-transferase activity","WP5115,WP1533,WP2806,WP5112,WP5323,WP2878,WP15,WP5109,WP430,WP5111,WP2882,WP5110,WP3601,WP5304,WP176,WP5333,WP3942,WP4522,WP5108","Network map of SARS-CoV-2 signaling pathway|Vitamin B12 metabolism|Complement system|Familial hyperlipidemia type 5|Fatty Acids and Lipoproteins Transport in Hepatocytes|PPAR-alpha pathway|Selenium micronutrient network|Familial hyperlipidemia type 2|Statin inhibition of cholesterol production|Familial hyperlipidemia type 4|Nuclear receptors meta-pathway|Familial hyperlipidemia type 3|Lipid particles composition|Cholesterol metabolism|Folate metabolism|Enterocyte cholesterol metabolism|PPAR signaling pathway|Metabolic pathway of LDL, HDL and TG, including diseases|Familial  hyperlipidemia type 1","R-HSA-109582,R-HSA-114608,R-HSA-1369062,R-HSA-1430728,R-HSA-1430728,R-HSA-1643685,R-HSA-174824,R-HSA-196854,R-HSA-196854,R-HSA-1989781,R-HSA-2168880,R-HSA-2173782,R-HSA-2173782,R-HSA-2187338,R-HSA-2187338,R-HSA-2262752,R-HSA-3000471,R-HSA-3000471,R-HSA-3000480,R-HSA-3000480,R-HSA-381426,R-HSA-382551,R-HSA-382556,R-HSA-392499,R-HSA-400206,R-HSA-556833,R-HSA-5619084,R-HSA-5619115,R-HSA-5653656,R-HSA-5653656,R-HSA-5682113,R-HSA-597592,R-HSA-6806667,R-HSA-6806667,R-HSA-76002,R-HSA-76005,R-HSA-8953897,R-HSA-8957275,R-HSA-8963888,R-HSA-8963896,R-HSA-8963898,R-HSA-8963899,R-HSA-8963901,R-HSA-8964011,R-HSA-8964043,R-HSA-8964058,R-HSA-9707616,R-HSA-9709957,R-HSA-9709957,R-HSA-975634,R-HSA-975634,R-HSA-977225","Hemostasis|Platelet degranulation |ABC transporters in lipid homeostasis|Metabolism|Metabolism|Disease|Plasma lipoprotein assembly, remodeling, and clearance|Metabolism of vitamins and cofactors|Metabolism of vitamins and cofactors|PPARA activates gene expression|Scavenging of heme from plasma|Binding and Uptake of Ligands by Scavenger Receptors|Binding and Uptake of Ligands by Scavenger Receptors|Visual phototransduction|Visual phototransduction|Cellular responses to stress|Scavenging by Class B Receptors|Scavenging by Class B Receptors|Scavenging by Class A Receptors|Scavenging by Class A Receptors|Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)|Transport of small molecules|ABC-family proteins mediated transport|Metabolism of proteins|Regulation of lipid metabolism by PPARalpha|Metabolism of lipids|ABC transporter disorders|Disorders of transmembrane transporters|Vesicle-mediated transport|Vesicle-mediated transport|Defective ABCA1 causes TGD|Post-translational protein modification|Metabolism of fat-soluble vitamins|Metabolism of fat-soluble vitamins|Platelet activation, signaling and aggregation|Response to elevated platelet cytosolic Ca2+|Cellular responses to stimuli|Post-translational protein phosphorylation|Chylomicron assembly|HDL assembly|Plasma lipoprotein assembly|Plasma lipoprotein remodeling|Chylomicron remodeling|HDL clearance|Plasma lipoprotein clearance|HDL remodeling|Heme signaling|Sensory Perception|Sensory Perception|Retinoid metabolism and transport|Retinoid metabolism and transport|Amyloid fiber formation"]
["APOA2",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.0546870638057252,0,0,0,0,0,0,0,0,336,"apolipoprotein A2","protein_coding","hsa03320,hsa04979","PPAR signaling pathway|Cholesterol metabolism","GO:0002719,GO:0005102,GO:0005319,GO:0005515,GO:0005543,GO:0005576,GO:0005769,GO:0005788,GO:0005829,GO:0006641,GO:0006656,GO:0008035,GO:0008203,GO:0008289,GO:0009395,GO:0009410,GO:0009749,GO:0010903,GO:0015485,GO:0018158,GO:0018206,GO:0019899,GO:0030300,GO:0030301,GO:0031072,GO:0031100,GO:0031210,GO:0031647,GO:0032375,GO:0032757,GO:0033344,GO:0033700,GO:0034190,GO:0034361,GO:0034364,GO:0034366,GO:0034370,GO:0034374,GO:0034375,GO:0034380,GO:0034384,GO:0042157,GO:0042627,GO:0042632,GO:0042803,GO:0043627,GO:0043691,GO:0046340,GO:0046982,GO:0050766,GO:0050821,GO:0050995,GO:0050996,GO:0051384,GO:0055102,GO:0060192,GO:0060228,GO:0060621,GO:0060695,GO:0070062,GO:0070653,GO:0072562,GO:0120009,GO:0120020,GO:1905920","negative regulation of cytokine production involved in immune response|signaling receptor binding|lipid transporter activity|protein binding|phospholipid binding|extracellular region|early endosome|endoplasmic reticulum lumen|cytosol|triglyceride metabolic process|phosphatidylcholine biosynthetic process|high-density lipoprotein particle binding|cholesterol metabolic process|lipid binding|phospholipid catabolic process|response to xenobiotic stimulus|response to glucose|negative regulation of very-low-density lipoprotein particle remodeling|cholesterol binding|protein oxidation|peptidyl-methionine modification|enzyme binding|regulation of intestinal cholesterol absorption|cholesterol transport|heat shock protein binding|animal organ regeneration|phosphatidylcholine binding|regulation of protein stability|negative regulation of cholesterol transport|positive regulation of interleukin-8 production|cholesterol efflux|phospholipid efflux|apolipoprotein receptor binding|very-low-density lipoprotein particle|high-density lipoprotein particle|spherical high-density lipoprotein particle|triglyceride-rich lipoprotein particle remodeling|low-density lipoprotein particle remodeling|high-density lipoprotein particle remodeling|high-density lipoprotein particle assembly|high-density lipoprotein particle clearance|lipoprotein metabolic process|chylomicron|cholesterol homeostasis|protein homodimerization activity|response to estrogen|reverse cholesterol transport|diacylglycerol catabolic process|protein heterodimerization activity|positive regulation of phagocytosis|protein stabilization|negative regulation of lipid catabolic process|positive regulation of lipid catabolic process|response to glucocorticoid|lipase inhibitor activity|negative regulation of lipase activity|phosphatidylcholine-sterol O-acyltransferase activator activity|negative regulation of cholesterol import|negative regulation of cholesterol transporter activity|extracellular exosome|high-density lipoprotein particle receptor binding|blood microparticle|intermembrane lipid transfer|cholesterol transfer activity|positive regulation of CoA-transferase activity","WP5115,WP5112,WP5323,WP2878,WP5109,WP430,WP5111,WP2882,WP5110,WP3601,WP5304,WP3942,WP4522,WP5108","Network map of SARS-CoV-2 signaling pathway|Familial hyperlipidemia type 5|Fatty Acids and Lipoproteins Transport in Hepatocytes|PPAR-alpha pathway|Familial hyperlipidemia type 2|Statin inhibition of cholesterol production|Familial hyperlipidemia type 4|Nuclear receptors meta-pathway|Familial hyperlipidemia type 3|Lipid particles composition|Cholesterol metabolism|PPAR signaling pathway|Metabolic pathway of LDL, HDL and TG, including diseases|Familial  hyperlipidemia type 1","R-HSA-1430728,R-HSA-1430728,R-HSA-174824,R-HSA-196854,R-HSA-196854,R-HSA-1989781,R-HSA-2187338,R-HSA-2187338,R-HSA-381426,R-HSA-382551,R-HSA-392499,R-HSA-400206,R-HSA-556833,R-HSA-597592,R-HSA-6806667,R-HSA-6806667,R-HSA-8957275,R-HSA-8963888,R-HSA-8963898,R-HSA-8963899,R-HSA-8963901,R-HSA-9709957,R-HSA-9709957,R-HSA-975634,R-HSA-975634","Metabolism|Metabolism|Plasma lipoprotein assembly, remodeling, and clearance|Metabolism of vitamins and cofactors|Metabolism of vitamins and cofactors|PPARA activates gene expression|Visual phototransduction|Visual phototransduction|Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)|Transport of small molecules|Metabolism of proteins|Regulation of lipid metabolism by PPARalpha|Metabolism of lipids|Post-translational protein modification|Metabolism of fat-soluble vitamins|Metabolism of fat-soluble vitamins|Post-translational protein phosphorylation|Chylomicron assembly|Plasma lipoprotein assembly|Plasma lipoprotein remodeling|Chylomicron remodeling|Sensory Perception|Sensory Perception|Retinoid metabolism and transport|Retinoid metabolism and transport"]
["APOA4",0,0,0,0,0.0179065117745648,0,0,0,0,0,0,0,0,0,0.0170422361507243,0,0,0,0,0,0,0,0,0,0,0,0,0,337,"apolipoprotein A4","protein_coding","hsa04975,hsa04979,hsa04977,hsa05417","Fat digestion and absorption|Cholesterol metabolism|Vitamin digestion and absorption|Lipid and atherosclerosis","GO:0002227,GO:0005319,GO:0005507,GO:0005515,GO:0005576,GO:0005615,GO:0005769,GO:0005788,GO:0005829,GO:0006869,GO:0006982,GO:0007159,GO:0008203,GO:0008289,GO:0009986,GO:0010898,GO:0014012,GO:0016042,GO:0016209,GO:0019430,GO:0030300,GO:0031210,GO:0032374,GO:0033344,GO:0033700,GO:0034014,GO:0034361,GO:0034364,GO:0034371,GO:0034372,GO:0034375,GO:0034378,GO:0034445,GO:0035634,GO:0042157,GO:0042627,GO:0042632,GO:0042744,GO:0042802,GO:0042803,GO:0043691,GO:0045202,GO:0045723,GO:0046470,GO:0051006,GO:0055088,GO:0060228,GO:0062023,GO:0065005,GO:0070062,GO:0070328,GO:0072562,GO:0120009,GO:0120020,GO:1905920","innate immune response in mucosa|lipid transporter activity|copper ion binding|protein binding|extracellular region|extracellular space|early endosome|endoplasmic reticulum lumen|cytosol|lipid transport|response to lipid hydroperoxide|leukocyte cell-cell adhesion|cholesterol metabolic process|lipid binding|cell surface|positive regulation of triglyceride catabolic process|peripheral nervous system axon regeneration|lipid catabolic process|antioxidant activity|removal of superoxide radicals|regulation of intestinal cholesterol absorption|phosphatidylcholine binding|regulation of cholesterol transport|cholesterol efflux|phospholipid efflux|response to triglyceride|very-low-density lipoprotein particle|high-density lipoprotein particle|chylomicron remodeling|very-low-density lipoprotein particle remodeling|high-density lipoprotein particle remodeling|chylomicron assembly|negative regulation of plasma lipoprotein oxidation|response to stilbenoid|lipoprotein metabolic process|chylomicron|cholesterol homeostasis|hydrogen peroxide catabolic process|identical protein binding|protein homodimerization activity|reverse cholesterol transport|synapse|positive regulation of fatty acid biosynthetic process|phosphatidylcholine metabolic process|positive regulation of lipoprotein lipase activity|lipid homeostasis|phosphatidylcholine-sterol O-acyltransferase activator activity|collagen-containing extracellular matrix|protein-lipid complex assembly|extracellular exosome|triglyceride homeostasis|blood microparticle|intermembrane lipid transfer|cholesterol transfer activity|positive regulation of CoA-transferase activity","WP5112,WP5323,WP5109,WP430,WP5111,WP5110,WP5304,WP5333,WP5108","Familial hyperlipidemia type 5|Fatty Acids and Lipoproteins Transport in Hepatocytes|Familial hyperlipidemia type 2|Statin inhibition of cholesterol production|Familial hyperlipidemia type 4|Familial hyperlipidemia type 3|Cholesterol metabolism|Enterocyte cholesterol metabolism|Familial  hyperlipidemia type 1","R-HSA-1430728,R-HSA-1430728,R-HSA-174824,R-HSA-174824,R-HSA-196854,R-HSA-196854,R-HSA-2187338,R-HSA-2187338,R-HSA-382551,R-HSA-382551,R-HSA-392499,R-HSA-6806667,R-HSA-6806667,R-HSA-8963888,R-HSA-8963889,R-HSA-8963898,R-HSA-8963899,R-HSA-8963899,R-HSA-8963901,R-HSA-9709957,R-HSA-9709957,R-HSA-975634,R-HSA-975634,R-HSA-977225","Metabolism|Metabolism|Plasma lipoprotein assembly, remodeling, and clearance|Plasma lipoprotein assembly, remodeling, and clearance|Metabolism of vitamins and cofactors|Metabolism of vitamins and cofactors|Visual phototransduction|Visual phototransduction|Transport of small molecules|Transport of small molecules|Metabolism of proteins|Metabolism of fat-soluble vitamins|Metabolism of fat-soluble vitamins|Chylomicron assembly|Assembly of active LPL and LIPC lipase complexes|Plasma lipoprotein assembly|Plasma lipoprotein remodeling|Plasma lipoprotein remodeling|Chylomicron remodeling|Sensory Perception|Sensory Perception|Retinoid metabolism and transport|Retinoid metabolism and transport|Amyloid fiber formation"]
["APOA5",0,0,0,0,0,0,0,0,0,0,0,0.0140156032129583,0,0,0,0,0,0,0,0,0,0,0,0.0136100693838111,0,0,0,0,116519,"apolipoprotein A5","protein_coding","hsa03320","PPAR signaling pathway","GO:0005515,GO:0005543,GO:0005576,GO:0005615,GO:0005769,GO:0005770,GO:0005788,GO:0005794,GO:0006641,GO:0006869,GO:0008047,GO:0008201,GO:0008289,GO:0010898,GO:0010902,GO:0019433,GO:0019899,GO:0031210,GO:0033344,GO:0033700,GO:0034361,GO:0034362,GO:0034364,GO:0034372,GO:0035473,GO:0042157,GO:0042246,GO:0042627,GO:0042632,GO:0045723,GO:0048260,GO:0050750,GO:0050996,GO:0051006,GO:0055090,GO:0060228,GO:0060229,GO:0060230,GO:0070325,GO:0070328","protein binding|phospholipid binding|extracellular region|extracellular space|early endosome|late endosome|endoplasmic reticulum lumen|Golgi apparatus|triglyceride metabolic process|lipid transport|enzyme activator activity|heparin binding|lipid binding|positive regulation of triglyceride catabolic process|positive regulation of very-low-density lipoprotein particle remodeling|triglyceride catabolic process|enzyme binding|phosphatidylcholine binding|cholesterol efflux|phospholipid efflux|very-low-density lipoprotein particle|low-density lipoprotein particle|high-density lipoprotein particle|very-low-density lipoprotein particle remodeling|lipase binding|lipoprotein metabolic process|tissue regeneration|chylomicron|cholesterol homeostasis|positive regulation of fatty acid biosynthetic process|positive regulation of receptor-mediated endocytosis|low-density lipoprotein particle receptor binding|positive regulation of lipid catabolic process|positive regulation of lipoprotein lipase activity|acylglycerol homeostasis|phosphatidylcholine-sterol O-acyltransferase activator activity|lipase activator activity|lipoprotein lipase activator activity|lipoprotein particle receptor binding|triglyceride homeostasis","WP5112,WP5323,WP2878,WP430,WP5111,WP2882,WP3942,WP5108","Familial hyperlipidemia type 5|Fatty Acids and Lipoproteins Transport in Hepatocytes|PPAR-alpha pathway|Statin inhibition of cholesterol production|Familial hyperlipidemia type 4|Nuclear receptors meta-pathway|PPAR signaling pathway|Familial  hyperlipidemia type 1","R-HSA-1430728,R-HSA-174824,R-HSA-174824,R-HSA-1989781,R-HSA-381426,R-HSA-382551,R-HSA-382551,R-HSA-392499,R-HSA-400206,R-HSA-556833,R-HSA-597592,R-HSA-8957275,R-HSA-8963889,R-HSA-8963899,R-HSA-8963899,R-HSA-8963901","Metabolism|Plasma lipoprotein assembly, remodeling, and clearance|Plasma lipoprotein assembly, remodeling, and clearance|PPARA activates gene expression|Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)|Transport of small molecules|Transport of small molecules|Metabolism of proteins|Regulation of lipid metabolism by PPARalpha|Metabolism of lipids|Post-translational protein modification|Post-translational protein phosphorylation|Assembly of active LPL and LIPC lipase complexes|Plasma lipoprotein remodeling|Plasma lipoprotein remodeling|Chylomicron remodeling"]
["APOBEC2",0,0,0,0,0,0,0,0,0,0,0,0.0166075886203762,0,0,0,0,0,0,0,0,0,0,0,0,0,0.0156847844419959,0,0,10930,"apolipoprotein B mRNA editing enzyme catalytic subunit 2","protein_coding",null,null,"GO:0003723,GO:0004126,GO:0005634,GO:0005737,GO:0006397,GO:0009972,GO:0016554,GO:0016556,GO:0042802,GO:0046872,GO:0080111","RNA binding|cytidine deaminase activity|nucleus|cytoplasm|mRNA processing|cytidine deamination|cytidine to uridine editing|mRNA modification|identical protein binding|metal ion binding|DNA demethylation",null,null,"R-HSA-72200,R-HSA-75072,R-HSA-75094,R-HSA-8953854","mRNA Editing: C to U Conversion|mRNA Editing|Formation of the Editosome|Metabolism of RNA"]
["APOBEC3A",0,0,0,0,0,0,0,0,0.0199663464116481,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.0196796890382988,0,0,0.0373224760787379,200315,"apolipoprotein B mRNA editing enzyme catalytic subunit 3A","protein_coding","hsa03250,hsa05170","Viral life cycle - HIV-1|Human immunodeficiency virus 1 infection","GO:0000932,GO:0003723,GO:0004126,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0008270,GO:0009972,GO:0010526,GO:0016554,GO:0044355,GO:0045071,GO:0045087,GO:0045869,GO:0047844,GO:0051607,GO:0070383,GO:0080111","P-body|RNA binding|cytidine deaminase activity|protein binding|nucleus|nucleoplasm|cytoplasm|zinc ion binding|cytidine deamination|retrotransposon silencing|cytidine to uridine editing|clearance of foreign intracellular DNA|negative regulation of viral genome replication|innate immune response|negative regulation of single stranded viral RNA replication via double stranded DNA intermediate|deoxycytidine deaminase activity|defense response to virus|DNA cytosine deamination|DNA demethylation",null,null,"R-HSA-72200,R-HSA-75072,R-HSA-75094,R-HSA-8953854","mRNA Editing: C to U Conversion|mRNA Editing|Formation of the Editosome|Metabolism of RNA"]
["APOBEC3B",6.74753060605456,6.19226156922506,4.37707636236868,5.26807276016252,4.53917685332418,4.4895215524571,3.97020518927871,4.1894097586475,3.76871695117674,4.16376354580723,3.30038222472717,3.99127357156943,2.83759837412242,1.21223825644322,2.20734472508186,1.31811579450694,8.88342050950096,9.44331145622388,10.8428605279023,10.1078203215261,8.01684130784996,9.18555935796082,9.90826259340133,8.09940364905841,7.78219069282174,10.358063946541,10.6472876240997,8.04886190881688,9582,"apolipoprotein B mRNA editing enzyme catalytic subunit 3B","protein_coding","hsa03250,hsa05170","Viral life cycle - HIV-1|Human immunodeficiency virus 1 infection","GO:0000932,GO:0003723,GO:0004126,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0008270,GO:0009972,GO:0010526,GO:0016554,GO:0044355,GO:0045087,GO:0045869,GO:0047844,GO:0051607,GO:0070383,GO:0080111","P-body|RNA binding|cytidine deaminase activity|protein binding|nucleus|nucleoplasm|cytoplasm|zinc ion binding|cytidine deamination|retrotransposon silencing|cytidine to uridine editing|clearance of foreign intracellular DNA|innate immune response|negative regulation of single stranded viral RNA replication via double stranded DNA intermediate|deoxycytidine deaminase activity|defense response to virus|DNA cytosine deamination|DNA demethylation",null,null,"R-HSA-72200,R-HSA-75072,R-HSA-75094,R-HSA-8953854","mRNA Editing: C to U Conversion|mRNA Editing|Formation of the Editosome|Metabolism of RNA"]
["APOBEC3B-AS1",0.153596668007083,0.146095914872208,0.0360505123862534,0.184135180099592,0.225132297610126,0.180293873340779,0.179130380215694,0.112962310342042,0.115873070200932,0.0739666391579632,0,0.154531009783899,0.438207208124967,0.0366089046105361,0.0714220210191325,0,0.553777095981593,0.071058793647935,0.106467987249671,0,0,0.401498058606324,0.454901175892473,0.0375149348399923,0.228418954820597,0.401347269133296,0.520214361152725,0.036099659910916,100874530,"APOBEC3B antisense RNA 1","non_coding"]
["APOBEC3C",17.760108524884,18.745006545053,17.1045501040971,15.3903024947567,15.1029371753795,16.5723346230353,17.4165948392439,14.9861337932816,11.7625190226134,13.0596997572284,11.6302852970622,12.3702540899363,12.6818226744728,12.7136467306611,12.1553040326139,11.1649650881069,15.8990158264464,15.8196386265518,16.819445383629,16.5588871648904,15.9161029543502,16.009452089052,17.9659296670316,16.1160414254604,16.0107519133856,15.4706373037313,16.7421722270119,15.6134852074157,27350,"apolipoprotein B mRNA editing enzyme catalytic subunit 3C","protein_coding","hsa03250,hsa05170","Viral life cycle - HIV-1|Human immunodeficiency virus 1 infection","GO:0000932,GO:0003723,GO:0004126,GO:0005515,GO:0005634,GO:0005737,GO:0008270,GO:0009972,GO:0010526,GO:0016554,GO:0044355,GO:0045071,GO:0045087,GO:0045869,GO:0047844,GO:0051607,GO:0070383,GO:0080111","P-body|RNA binding|cytidine deaminase activity|protein binding|nucleus|cytoplasm|zinc ion binding|cytidine deamination|retrotransposon silencing|cytidine to uridine editing|clearance of foreign intracellular DNA|negative regulation of viral genome replication|innate immune response|negative regulation of single stranded viral RNA replication via double stranded DNA intermediate|deoxycytidine deaminase activity|defense response to virus|DNA cytosine deamination|DNA demethylation",null,null,"R-HSA-72200,R-HSA-75072,R-HSA-75094,R-HSA-8953854","mRNA Editing: C to U Conversion|mRNA Editing|Formation of the Editosome|Metabolism of RNA"]
["APOBEC3D",0.604088585359967,0.894850896659401,1.11568521800807,0.845290064824565,0.696735663140231,1.05084436419034,0.979386469699502,0.854562782719812,0.87658275590654,1.28762277608379,1.0430879301228,1.19559995078946,0.913521970060663,1.02911100771087,0.920981975669196,1.12675621221808,0.695049254486229,0.870483274867889,1.07085986587858,0.904687172362898,0.719722847706549,1.22372295866719,0.723463332269844,1.03523027757942,0.873815788591799,1.0915273134748,1.2745442962996,0.912385085683827,140564,"apolipoprotein B mRNA editing enzyme catalytic subunit 3D","protein_coding","hsa03250,hsa05170","Viral life cycle - HIV-1|Human immunodeficiency virus 1 infection","GO:0000932,GO:0003723,GO:0004126,GO:0005634,GO:0005737,GO:0008270,GO:0009972,GO:0016554,GO:0044355,GO:0045087,GO:0045869,GO:0047844,GO:0051607,GO:0070383,GO:0080111","P-body|RNA binding|cytidine deaminase activity|nucleus|cytoplasm|zinc ion binding|cytidine deamination|cytidine to uridine editing|clearance of foreign intracellular DNA|innate immune response|negative regulation of single stranded viral RNA replication via double stranded DNA intermediate|deoxycytidine deaminase activity|defense response to virus|DNA cytosine deamination|DNA demethylation"]
["APOBEC3F",1.29149742745785,1.57482587346705,2.03877959015218,1.66550892322756,1.38720810400075,1.61809804434703,1.7618147378132,1.76573911072056,1.37029979541097,1.2925933896784,1.4397355460687,1.44184159272662,1.28271812235729,1.83567507404259,1.60562850154995,1.51548287692614,1.22548640714946,1.50386149949273,1.50216554239629,1.30029884485982,1.38130082414479,1.36223697074165,1.40482178249405,1.24858000170861,1.13332261759436,1.38094971732786,1.47164754967721,1.29023995894263,200316,"apolipoprotein B mRNA editing enzyme catalytic subunit 3F","protein_coding","hsa03250,hsa05170","Viral life cycle - HIV-1|Human immunodeficiency virus 1 infection","GO:0000932,GO:0002230,GO:0003723,GO:0004126,GO:0005515,GO:0005634,GO:0005737,GO:0008270,GO:0009972,GO:0010526,GO:0016553,GO:0016554,GO:0030895,GO:0042802,GO:0044355,GO:0045071,GO:0045087,GO:0045869,GO:0047844,GO:0048525,GO:0051607,GO:0070383,GO:0080111,GO:1990904","P-body|positive regulation of defense response to virus by host|RNA binding|cytidine deaminase activity|protein binding|nucleus|cytoplasm|zinc ion binding|cytidine deamination|retrotransposon silencing|base conversion or substitution editing|cytidine to uridine editing|apolipoprotein B mRNA editing enzyme complex|identical protein binding|clearance of foreign intracellular DNA|negative regulation of viral genome replication|innate immune response|negative regulation of single stranded viral RNA replication via double stranded DNA intermediate|deoxycytidine deaminase activity|negative regulation of viral process|defense response to virus|DNA cytosine deamination|DNA demethylation|ribonucleoprotein complex"]
["APOBEC3G",3.09297825998334,3.35726755781187,4.27029220018052,4.00631223276299,3.36367345627484,3.94323728791446,3.97889971760748,4.131968568845,2.44497183440174,2.29202725233086,2.50496190547069,2.62122808145589,2.77529260037784,2.82388676347049,3.26900364185653,3.16722227779169,4.34511689662361,3.83821081132353,3.94150007657234,3.66710425480853,4.45109345903439,4.28892634566603,3.90841658250595,4.14513696604327,3.54265218617139,4.70221707229212,4.17614076571319,3.75613842611965,60489,"apolipoprotein B mRNA editing enzyme catalytic subunit 3G","protein_coding","hsa03250,hsa05170","Viral life cycle - HIV-1|Human immunodeficiency virus 1 infection","GO:0000932,GO:0002230,GO:0003723,GO:0004126,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0008270,GO:0008829,GO:0009972,GO:0010526,GO:0016553,GO:0016554,GO:0030895,GO:0042802,GO:0045071,GO:0045087,GO:0045869,GO:0047844,GO:0048525,GO:0051607,GO:0070383,GO:0080111,GO:1990904","P-body|positive regulation of defense response to virus by host|RNA binding|cytidine deaminase activity|protein binding|nucleus|cytoplasm|cytosol|zinc ion binding|dCTP deaminase activity|cytidine deamination|retrotransposon silencing|base conversion or substitution editing|cytidine to uridine editing|apolipoprotein B mRNA editing enzyme complex|identical protein binding|negative regulation of viral genome replication|innate immune response|negative regulation of single stranded viral RNA replication via double stranded DNA intermediate|deoxycytidine deaminase activity|negative regulation of viral process|defense response to virus|DNA cytosine deamination|DNA demethylation|ribonucleoprotein complex","WP3300","Dual hijack model of Vif in HIV infection","R-HSA-162906,R-HSA-162909,R-HSA-1643685,R-HSA-180585,R-HSA-180689,R-HSA-5663205,R-HSA-9824446","HIV Infection|Host Interactions of HIV factors|Disease|Vif-mediated degradation of APOBEC3G|APOBEC3G mediated resistance to HIV-1 infection|Infectious disease|Viral Infection Pathways"]
["APOBEC3H",0.0227286806367985,0,0,0.0653943826795517,0.0222095099665976,0.0640301681712783,0,0.0222876733727131,0,0,0,0.182935529288865,0.0864590950263425,0.0216690143647524,0,0,0.0218522496559347,0.0210300476985035,0.0210063313797834,0.0218563813186456,0.0429050084636172,0.172835589232954,0.0224382114584398,0,0.0901349669949742,0,0,0.0213675895931391,164668,"apolipoprotein B mRNA editing enzyme catalytic subunit 3H","protein_coding","hsa03250,hsa05170","Viral life cycle - HIV-1|Human immunodeficiency virus 1 infection","GO:0000932,GO:0003723,GO:0004126,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0008270,GO:0009972,GO:0010526,GO:0016554,GO:0044355,GO:0044828,GO:0045087,GO:0045869,GO:0047844,GO:0051607,GO:0070383,GO:0080111","P-body|RNA binding|cytidine deaminase activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|zinc ion binding|cytidine deamination|retrotransposon silencing|cytidine to uridine editing|clearance of foreign intracellular DNA|negative regulation by host of viral genome replication|innate immune response|negative regulation of single stranded viral RNA replication via double stranded DNA intermediate|deoxycytidine deaminase activity|defense response to virus|DNA cytosine deamination|DNA demethylation",null,null,"R-HSA-72200,R-HSA-75072,R-HSA-75094,R-HSA-8953854","mRNA Editing: C to U Conversion|mRNA Editing|Formation of the Editosome|Metabolism of RNA"]
["APOBR",0.0142174130987569,0.0811387122154194,0.0533912651796411,0.00681766331381402,0.0486243016199087,0.0333771885773277,0.026529436057261,0.0487954283597744,0,0.0410795733298181,0.0133706550717407,0.0143038988486679,0,0.0135545627830149,0.0132221146506938,0.0471809354509568,0.00683459074154498,0.0723517938488073,0,0.0205076489271469,0.0134191297568169,0.0337854379005609,0,0.0277800466853107,0.0140954734778533,0.0202636495203951,0.0206368942997973,0.0133660133214467,55911,"apolipoprotein B receptor","protein_coding",null,null,"GO:0005886,GO:0006641,GO:0006869,GO:0006897,GO:0008203,GO:0016020,GO:0030229,GO:0034361,GO:0034362,GO:0042627","plasma membrane|triglyceride metabolic process|lipid transport|endocytosis|cholesterol metabolic process|membrane|very-low-density lipoprotein particle receptor activity|very-low-density lipoprotein particle|low-density lipoprotein particle|chylomicron","WP5323","Fatty Acids and Lipoproteins Transport in Hepatocytes","R-HSA-174824,R-HSA-382551,R-HSA-8964043,R-HSA-8964046","Plasma lipoprotein assembly, remodeling, and clearance|Transport of small molecules|Plasma lipoprotein clearance|VLDL clearance"]
["APOC1",2.94424680967461,2.61376938961904,3.71626531931205,3.98456015694152,2.04586243265125,3.44063725668577,3.75417276944279,3.2720684748105,1.84271931057405,1.32332062435278,2.46123903068158,3.15963404470769,2.20885150357651,2.99411080038015,2.67728566169777,2.57446929613251,0.880666876910534,0.54484157556754,0.725636184944363,0.471875028712022,0.771925668049909,0.559723021684633,0.742802830295294,0.76705293954392,0.908131669893539,1.15010966112844,0.538162117371413,0.399812495566771,341,"apolipoprotein C1","protein_coding","hsa04979","Cholesterol metabolism","GO:0004859,GO:0005504,GO:0005515,GO:0005576,GO:0005783,GO:0006629,GO:0006641,GO:0008203,GO:0010900,GO:0010916,GO:0031210,GO:0032374,GO:0032375,GO:0033344,GO:0033700,GO:0034361,GO:0034364,GO:0034369,GO:0034375,GO:0034379,GO:0034382,GO:0034447,GO:0042157,GO:0042627,GO:0045717,GO:0045833,GO:0048261,GO:0050995,GO:0051005,GO:0055102,GO:0060228","phospholipase inhibitor activity|fatty acid binding|protein binding|extracellular region|endoplasmic reticulum|lipid metabolic process|triglyceride metabolic process|cholesterol metabolic process|negative regulation of phosphatidylcholine catabolic process|negative regulation of very-low-density lipoprotein particle clearance|phosphatidylcholine binding|regulation of cholesterol transport|negative regulation of cholesterol transport|cholesterol efflux|phospholipid efflux|very-low-density lipoprotein particle|high-density lipoprotein particle|plasma lipoprotein particle remodeling|high-density lipoprotein particle remodeling|very-low-density lipoprotein particle assembly|chylomicron remnant clearance|very-low-density lipoprotein particle clearance|lipoprotein metabolic process|chylomicron|negative regulation of fatty acid biosynthetic process|negative regulation of lipid metabolic process|negative regulation of receptor-mediated endocytosis|negative regulation of lipid catabolic process|negative regulation of lipoprotein lipase activity|lipase inhibitor activity|phosphatidylcholine-sterol O-acyltransferase activator activity","WP5115,WP5323,WP430,WP5304","Network map of SARS-CoV-2 signaling pathway|Fatty Acids and Lipoproteins Transport in Hepatocytes|Statin inhibition of cholesterol production|Cholesterol metabolism","R-HSA-162582,R-HSA-174824,R-HSA-174824,R-HSA-382551,R-HSA-382551,R-HSA-8866423,R-HSA-8963898,R-HSA-8964043,R-HSA-8964043,R-HSA-8964046,R-HSA-8964046,R-HSA-9006931,R-HSA-9024446,R-HSA-9029569","Signal Transduction|Plasma lipoprotein assembly, remodeling, and clearance|Plasma lipoprotein assembly, remodeling, and clearance|Transport of small molecules|Transport of small molecules|VLDL assembly|Plasma lipoprotein assembly|Plasma lipoprotein clearance|Plasma lipoprotein clearance|VLDL clearance|VLDL clearance|Signaling by Nuclear Receptors|NR1H2 and NR1H3-mediated signaling|NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux"]
["APOC3",0,0,0,0.193290312418562,0,0,0,0.0494078142430613,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,345,"apolipoprotein C3","protein_coding","hsa03320,hsa04979","PPAR signaling pathway|Cholesterol metabolism","GO:0005515,GO:0005543,GO:0005576,GO:0005615,GO:0005769,GO:0006641,GO:0007186,GO:0010897,GO:0010903,GO:0010916,GO:0010987,GO:0010989,GO:0015485,GO:0019433,GO:0030234,GO:0032489,GO:0033344,GO:0033700,GO:0034361,GO:0034363,GO:0034366,GO:0034375,GO:0034379,GO:0034382,GO:0042157,GO:0042627,GO:0042632,GO:0043691,GO:0045717,GO:0045833,GO:0048261,GO:0050995,GO:0051005,GO:0055102,GO:0060621,GO:0062023,GO:0070062,GO:0070328,GO:0070653","protein binding|phospholipid binding|extracellular region|extracellular space|early endosome|triglyceride metabolic process|G protein-coupled receptor signaling pathway|negative regulation of triglyceride catabolic process|negative regulation of very-low-density lipoprotein particle remodeling|negative regulation of very-low-density lipoprotein particle clearance|negative regulation of high-density lipoprotein particle clearance|negative regulation of low-density lipoprotein particle clearance|cholesterol binding|triglyceride catabolic process|enzyme regulator activity|regulation of Cdc42 protein signal transduction|cholesterol efflux|phospholipid efflux|very-low-density lipoprotein particle|intermediate-density lipoprotein particle|spherical high-density lipoprotein particle|high-density lipoprotein particle remodeling|very-low-density lipoprotein particle assembly|chylomicron remnant clearance|lipoprotein metabolic process|chylomicron|cholesterol homeostasis|reverse cholesterol transport|negative regulation of fatty acid biosynthetic process|negative regulation of lipid metabolic process|negative regulation of receptor-mediated endocytosis|negative regulation of lipid catabolic process|negative regulation of lipoprotein lipase activity|lipase inhibitor activity|negative regulation of cholesterol import|collagen-containing extracellular matrix|extracellular exosome|triglyceride homeostasis|high-density lipoprotein particle receptor binding","WP5323,WP2878,WP430,WP2882,WP3601,WP5304,WP3942","Fatty Acids and Lipoproteins Transport in Hepatocytes|PPAR-alpha pathway|Statin inhibition of cholesterol production|Nuclear receptors meta-pathway|Lipid particles composition|Cholesterol metabolism|PPAR signaling pathway","R-HSA-1430728,R-HSA-1430728,R-HSA-174824,R-HSA-196854,R-HSA-196854,R-HSA-2187338,R-HSA-2187338,R-HSA-382551,R-HSA-6806667,R-HSA-6806667,R-HSA-8963888,R-HSA-8963898,R-HSA-8963899,R-HSA-8963901,R-HSA-8964058,R-HSA-9709957,R-HSA-9709957,R-HSA-975634,R-HSA-975634","Metabolism|Metabolism|Plasma lipoprotein assembly, remodeling, and clearance|Metabolism of vitamins and cofactors|Metabolism of vitamins and cofactors|Visual phototransduction|Visual phototransduction|Transport of small molecules|Metabolism of fat-soluble vitamins|Metabolism of fat-soluble vitamins|Chylomicron assembly|Plasma lipoprotein assembly|Plasma lipoprotein remodeling|Chylomicron remodeling|HDL remodeling|Sensory Perception|Sensory Perception|Retinoid metabolism and transport|Retinoid metabolism and transport"]
["APOD",0,0.0594891718331149,0,0,0,0,0,0,0.0629102051670956,0.150593331464298,0.0588184733550356,0.125847759708001,0.0297391202729821,0.0298137483023159,0.087247550038453,0.207552328573118,0,0,0,0.180429245317265,0,0.029724914273533,0.0308720635611481,0.0916548176021157,0,0,0.0302610607829974,0,347,"apolipoprotein D","protein_coding",null,null,"GO:0000302,GO:0001525,GO:0005319,GO:0005515,GO:0005576,GO:0005615,GO:0005737,GO:0005783,GO:0006006,GO:0006629,GO:0006869,GO:0007420,GO:0010642,GO:0014012,GO:0015485,GO:0022626,GO:0030425,GO:0042246,GO:0042308,GO:0043025,GO:0048471,GO:0048662,GO:0048678,GO:0051895,GO:0060588,GO:0070062,GO:0071638,GO:1900016,GO:2000098,GO:2000405","response to reactive oxygen species|angiogenesis|lipid transporter activity|protein binding|extracellular region|extracellular space|cytoplasm|endoplasmic reticulum|glucose metabolic process|lipid metabolic process|lipid transport|brain development|negative regulation of platelet-derived growth factor receptor signaling pathway|peripheral nervous system axon regeneration|cholesterol binding|cytosolic ribosome|dendrite|tissue regeneration|negative regulation of protein import into nucleus|neuronal cell body|perinuclear region of cytoplasm|negative regulation of smooth muscle cell proliferation|response to axon injury|negative regulation of focal adhesion assembly|negative regulation of lipoprotein lipid oxidation|extracellular exosome|negative regulation of monocyte chemotactic protein-1 production|negative regulation of cytokine production involved in inflammatory response|negative regulation of smooth muscle cell-matrix adhesion|negative regulation of T cell migration","WP5115","Network map of SARS-CoV-2 signaling pathway","R-HSA-162582,R-HSA-382551,R-HSA-425397,R-HSA-425407,R-HSA-804914,R-HSA-9006931,R-HSA-9024446,R-HSA-9029569","Signal Transduction|Transport of small molecules|Transport of vitamins, nucleosides, and related molecules|SLC-mediated transmembrane transport|Transport of fatty acids|Signaling by Nuclear Receptors|NR1H2 and NR1H3-mediated signaling|NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux"]
["APOE",15.1306325062456,16.2088809989969,15.8194042885345,17.1861937422054,15.438395453195,18.6216610135316,15.8991605960289,22.9112543574105,4.18916871515944,5.94317489812598,6.36014865603912,5.93914911061373,4.05147564393639,7.01225276335194,5.52551327885863,6.28549227587524,0.440823837141407,0.371207914939,0.406102556610724,0.624618511901536,0.667171361233328,0.308709350648017,0.282902751130861,0.31729499105632,0.814440653226381,0.399356177082316,0.184869131076851,0.520848246964159,348,"apolipoprotein E","protein_coding","hsa04979,hsa05010","Cholesterol metabolism|Alzheimer disease","GO:0000302,GO:0001540,GO:0001937,GO:0002021,GO:0005102,GO:0005198,GO:0005319,GO:0005515,GO:0005543,GO:0005576,GO:0005615,GO:0005634,GO:0005737,GO:0005769,GO:0005783,GO:0005788,GO:0005794,GO:0005886,GO:0006641,GO:0006707,GO:0006874,GO:0006898,GO:0007010,GO:0007186,GO:0007263,GO:0007271,GO:0007616,GO:0008201,GO:0008203,GO:0008289,GO:0010467,GO:0010544,GO:0010596,GO:0010629,GO:0010875,GO:0010877,GO:0010976,GO:0010977,GO:0015909,GO:0016020,GO:0016209,GO:0017038,GO:0019068,GO:0019899,GO:0019934,GO:0030195,GO:0030425,GO:0030516,GO:0030669,GO:0031012,GO:0031175,GO:0032438,GO:0032489,GO:0032805,GO:0033344,GO:0033700,GO:0034360,GO:0034361,GO:0034362,GO:0034363,GO:0034364,GO:0034365,GO:0034372,GO:0034374,GO:0034375,GO:0034380,GO:0034382,GO:0034384,GO:0034447,GO:0035641,GO:0042158,GO:0042159,GO:0042311,GO:0042470,GO:0042627,GO:0042632,GO:0042802,GO:0042803,GO:0042982,GO:0043025,GO:0043083,GO:0043254,GO:0043395,GO:0043407,GO:0043524,GO:0043537,GO:0043691,GO:0044794,GO:0044877,GO:0045088,GO:0045541,GO:0045807,GO:0045893,GO:0046889,GO:0046907,GO:0046911,GO:0046983,GO:0048156,GO:0048168,GO:0048662,GO:0048844,GO:0050709,GO:0050728,GO:0050750,GO:0051000,GO:0051044,GO:0051246,GO:0051248,GO:0051651,GO:0055089,GO:0060228,GO:0060999,GO:0061136,GO:0061771,GO:0062023,GO:0070062,GO:0070326,GO:0070328,GO:0070374,GO:0071682,GO:0071813,GO:0071830,GO:0071831,GO:0072562,GO:0090090,GO:0090181,GO:0090205,GO:0090209,GO:0097113,GO:0097114,GO:0097487,GO:0098869,GO:0098978,GO:0120009,GO:0120020,GO:1900221,GO:1900223,GO:1900272,GO:1902430,GO:1902952,GO:1902991,GO:1902995,GO:1903002,GO:1903561,GO:1905860,GO:1905890,GO:1905906,GO:1905907,GO:1905908,GO:1905920,GO:1990777,GO:2000822","response to reactive oxygen species|amyloid-beta binding|negative regulation of endothelial cell proliferation|response to dietary excess|signaling receptor binding|structural molecule activity|lipid transporter activity|protein binding|phospholipid binding|extracellular region|extracellular space|nucleus|cytoplasm|early endosome|endoplasmic reticulum|endoplasmic reticulum lumen|Golgi apparatus|plasma membrane|triglyceride metabolic process|cholesterol catabolic process|intracellular calcium ion homeostasis|receptor-mediated endocytosis|cytoskeleton organization|G protein-coupled receptor signaling pathway|nitric oxide mediated signal transduction|synaptic transmission, cholinergic|long-term memory|heparin binding|cholesterol metabolic process|lipid binding|gene expression|negative regulation of platelet activation|negative regulation of endothelial cell migration|negative regulation of gene expression|positive regulation of cholesterol efflux|lipid transport involved in lipid storage|positive regulation of neuron projection development|negative regulation of neuron projection development|long-chain fatty acid transport|membrane|antioxidant activity|protein import|virion assembly|enzyme binding|cGMP-mediated signaling|negative regulation of blood coagulation|dendrite|regulation of axon extension|clathrin-coated endocytic vesicle membrane|extracellular matrix|neuron projection development|melanosome organization|regulation of Cdc42 protein signal transduction|positive regulation of low-density lipoprotein particle receptor catabolic process|cholesterol efflux|phospholipid efflux|chylomicron remnant|very-low-density lipoprotein particle|low-density lipoprotein particle|intermediate-density lipoprotein particle|high-density lipoprotein particle|discoidal high-density lipoprotein particle|very-low-density lipoprotein particle remodeling|low-density lipoprotein particle remodeling|high-density lipoprotein particle remodeling|high-density lipoprotein particle assembly|chylomicron remnant clearance|high-density lipoprotein particle clearance|very-low-density lipoprotein particle clearance|locomotory exploration behavior|lipoprotein biosynthetic process|lipoprotein catabolic process|vasodilation|melanosome|chylomicron|cholesterol homeostasis|identical protein binding|protein homodimerization activity|amyloid precursor protein metabolic process|neuronal cell body|synaptic cleft|regulation of protein-containing complex assembly|heparan sulfate proteoglycan binding|negative regulation of MAP kinase activity|negative regulation of neuron apoptotic process|negative regulation of blood vessel endothelial cell migration|reverse cholesterol transport|positive regulation by host of viral process|protein-containing complex binding|regulation of innate immune response|negative regulation of cholesterol biosynthetic process|positive regulation of endocytosis|positive regulation of DNA-templated transcription|positive regulation of lipid biosynthetic process|intracellular transport|metal chelating activity|protein dimerization activity|tau protein binding|regulation of neuronal synaptic plasticity|negative regulation of smooth muscle cell proliferation|artery morphogenesis|negative regulation of protein secretion|negative regulation of inflammatory response|low-density lipoprotein particle receptor binding|positive regulation of nitric-oxide synthase activity|positive regulation of membrane protein ectodomain proteolysis|regulation of protein metabolic process|negative regulation of protein metabolic process|maintenance of location in cell|fatty acid homeostasis|phosphatidylcholine-sterol O-acyltransferase activator activity|positive regulation of dendritic spine development|regulation of proteasomal protein catabolic process|response to caloric restriction|collagen-containing extracellular matrix|extracellular exosome|very-low-density lipoprotein particle receptor binding|triglyceride homeostasis|positive regulation of ERK1 and ERK2 cascade|endocytic vesicle lumen|lipoprotein particle binding|triglyceride-rich lipoprotein particle clearance|intermediate-density lipoprotein particle clearance|blood microparticle|negative regulation of canonical Wnt signaling pathway|regulation of cholesterol metabolic process|positive regulation of cholesterol metabolic process|negative regulation of triglyceride metabolic process|AMPA glutamate receptor clustering|NMDA glutamate receptor clustering|multivesicular body, internal vesicle|cellular oxidant detoxification|glutamatergic synapse|intermembrane lipid transfer|cholesterol transfer activity|regulation of amyloid-beta clearance|positive regulation of amyloid-beta clearance|negative regulation of long-term synaptic potentiation|negative regulation of amyloid-beta formation|positive regulation of dendritic spine maintenance|regulation of amyloid precursor protein catabolic process|positive regulation of phospholipid efflux|positive regulation of lipid transport across blood-brain barrier|extracellular vesicle|positive regulation of heparan sulfate proteoglycan binding|regulation of cellular response to very-low-density lipoprotein particle stimulus|regulation of amyloid fibril formation|negative regulation of amyloid fibril formation|positive regulation of amyloid fibril formation|positive regulation of CoA-transferase activity|lipoprotein particle|regulation of behavioral fear response","WP1533,WP5124,WP2864,WP5323,WP2059,WP430,WP5110,WP3601,WP5304,WP3298,WP3926,WP4522","Vitamin B12 metabolism|Alzheimer's disease|Apoptosis-related network due to altered Notch3 in ovarian cancer|Fatty Acids and Lipoproteins Transport in Hepatocytes|Alzheimer's disease and miRNA effects|Statin inhibition of cholesterol production|Familial hyperlipidemia type 3|Lipid particles composition|Cholesterol metabolism|Melatonin metabolism and effects|ApoE and miR-146 in inflammation and atherosclerosis|Metabolic pathway of LDL, HDL and TG, including diseases","R-HSA-1236394,R-HSA-1251985,R-HSA-1430728,R-HSA-1430728,R-HSA-162582,R-HSA-174824,R-HSA-174824,R-HSA-196854,R-HSA-196854,R-HSA-212436,R-HSA-2173782,R-HSA-2173782,R-HSA-2187338,R-HSA-2187338,R-HSA-3000480,R-HSA-3000480,R-HSA-381426,R-HSA-382551,R-HSA-382551,R-HSA-392499,R-HSA-5653656,R-HSA-5653656,R-HSA-597592,R-HSA-6806667,R-HSA-6806667,R-HSA-73857,R-HSA-74160,R-HSA-8864260,R-HSA-8957275,R-HSA-8963888,R-HSA-8963898,R-HSA-8963899,R-HSA-8963901,R-HSA-8964026,R-HSA-8964026,R-HSA-8964043,R-HSA-8964043,R-HSA-8964058,R-HSA-9006931,R-HSA-9006934,R-HSA-9024446,R-HSA-9029569,R-HSA-9709957,R-HSA-9709957,R-HSA-975634,R-HSA-975634,R-HSA-977225","Signaling by ERBB4|Nuclear signaling by ERBB4|Metabolism|Metabolism|Signal Transduction|Plasma lipoprotein assembly, remodeling, and clearance|Plasma lipoprotein assembly, remodeling, and clearance|Metabolism of vitamins and cofactors|Metabolism of vitamins and cofactors|Generic Transcription Pathway|Binding and Uptake of Ligands by Scavenger Receptors|Binding and Uptake of Ligands by Scavenger Receptors|Visual phototransduction|Visual phototransduction|Scavenging by Class A Receptors|Scavenging by Class A Receptors|Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)|Transport of small molecules|Transport of small molecules|Metabolism of proteins|Vesicle-mediated transport|Vesicle-mediated transport|Post-translational protein modification|Metabolism of fat-soluble vitamins|Metabolism of fat-soluble vitamins|RNA Polymerase II Transcription|Gene expression (Transcription)|Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors|Post-translational protein phosphorylation|Chylomicron assembly|Plasma lipoprotein assembly|Plasma lipoprotein remodeling|Chylomicron remodeling|Chylomicron clearance|Chylomicron clearance|Plasma lipoprotein clearance|Plasma lipoprotein clearance|HDL remodeling|Signaling by Nuclear Receptors|Signaling by Receptor Tyrosine Kinases|NR1H2 and NR1H3-mediated signaling|NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux|Sensory Perception|Sensory Perception|Retinoid metabolism and transport|Retinoid metabolism and transport|Amyloid fiber formation"]
["APOF",0,0,0,0,0,0,0,0,0,0,0,0.015497252695471,0,0,0,0,0,0,0,0,0,0,0,0,0.0305428773874398,0.0292722891357479,0,0,319,"apolipoprotein F","protein_coding",null,null,"GO:0005102,GO:0005319,GO:0005615,GO:0006629,GO:0006869,GO:0008203,GO:0015485,GO:0034362,GO:0034364","signaling receptor binding|lipid transporter activity|extracellular space|lipid metabolic process|lipid transport|cholesterol metabolic process|cholesterol binding|low-density lipoprotein particle|high-density lipoprotein particle","WP5323","Fatty Acids and Lipoproteins Transport in Hepatocytes","R-HSA-174824,R-HSA-382551,R-HSA-8963899,R-HSA-8964041","Plasma lipoprotein assembly, remodeling, and clearance|Transport of small molecules|Plasma lipoprotein remodeling|LDL remodeling"]
["APOH",0,0,0,0,0,0,0,0,0,0,0,0,0,0.0875620137533095,0,0,0,0,0,0,0,0.0218252777715378,0,0,0,0,0,0,350,"apolipoprotein H","protein_coding","hsa04979","Cholesterol metabolism","GO:0001937,GO:0005515,GO:0005543,GO:0005576,GO:0005615,GO:0006641,GO:0007597,GO:0008201,GO:0008289,GO:0009986,GO:0010596,GO:0016525,GO:0030194,GO:0030195,GO:0031089,GO:0031639,GO:0033033,GO:0034197,GO:0034361,GO:0034364,GO:0034392,GO:0042627,GO:0042802,GO:0051006,GO:0051917,GO:0051918,GO:0060230,GO:0062023,GO:0070062","negative regulation of endothelial cell proliferation|protein binding|phospholipid binding|extracellular region|extracellular space|triglyceride metabolic process|blood coagulation, intrinsic pathway|heparin binding|lipid binding|cell surface|negative regulation of endothelial cell migration|negative regulation of angiogenesis|positive regulation of blood coagulation|negative regulation of blood coagulation|platelet dense granule lumen|plasminogen activation|negative regulation of myeloid cell apoptotic process|triglyceride transport|very-low-density lipoprotein particle|high-density lipoprotein particle|negative regulation of smooth muscle cell apoptotic process|chylomicron|identical protein binding|positive regulation of lipoprotein lipase activity|regulation of fibrinolysis|negative regulation of fibrinolysis|lipoprotein lipase activator activity|collagen-containing extracellular matrix|extracellular exosome","WP5115,WP5323,WP5304","Network map of SARS-CoV-2 signaling pathway|Fatty Acids and Lipoproteins Transport in Hepatocytes|Cholesterol metabolism","R-HSA-109582,R-HSA-114608,R-HSA-76002,R-HSA-76005","Hemostasis|Platelet degranulation |Platelet activation, signaling and aggregation|Response to elevated platelet cytosolic Ca2+"]
["APOL1",4.42068634560707,4.71855127523529,4.54816553707533,5.51479188221334,5.17228267835547,5.46217073734024,4.34929004915567,5.47567736641967,2.4740543570892,2.35293260211678,2.72731687533634,2.70867517827746,2.72629993156046,2.89158434906216,2.75111284169751,2.60785826550728,7.04642091772189,6.10470389547398,3.17178767687507,5.28181957744358,6.27439457926634,6.05028455471629,2.75633092273195,4.91151910477593,6.21167181145605,5.8348316776828,2.85455832620377,5.76521806658684,8542,"apolipoprotein L1","protein_coding","hsa05143","African trypanosomiasis","GO:0005254,GO:0005515,GO:0005576,GO:0005615,GO:0005788,GO:0006869,GO:0008203,GO:0008289,GO:0016020,GO:0034361,GO:0034364,GO:0042157,GO:0045087,GO:0051838,GO:0072562,GO:1902476","chloride channel activity|protein binding|extracellular region|extracellular space|endoplasmic reticulum lumen|lipid transport|cholesterol metabolic process|lipid binding|membrane|very-low-density lipoprotein particle|high-density lipoprotein particle|lipoprotein metabolic process|innate immune response|cytolysis by host of symbiont cells|blood microparticle|chloride transmembrane transport","WP5115,WP5323,WP4758","Network map of SARS-CoV-2 signaling pathway|Fatty Acids and Lipoproteins Transport in Hepatocytes|Nephrotic syndrome","R-HSA-2168880,R-HSA-2173782,R-HSA-381426,R-HSA-392499,R-HSA-5653656,R-HSA-597592,R-HSA-8957275","Scavenging of heme from plasma|Binding and Uptake of Ligands by Scavenger Receptors|Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)|Metabolism of proteins|Vesicle-mediated transport|Post-translational protein modification|Post-translational protein phosphorylation"]
["APOL2",10.9678374387034,11.8343030231249,11.1054120643849,14.1580313739965,12.1790844139732,12.779975516727,10.5937338318443,12.3364383835801,12.2506129059808,13.0443992634786,13.3410615482251,12.9580777647905,10.9785496725341,13.5871759270364,10.7497295436657,12.9799428093252,14.9929976752768,14.9825369652879,11.7688341184781,13.8099196275101,14.4294514590275,15.0449426824879,9.33643409622732,12.8326669366037,14.7660425431223,16.0724202597674,9.6671391680233,15.0103441340901,23780,"apolipoprotein L2","protein_coding",null,null,"GO:0005102,GO:0005515,GO:0005576,GO:0005789,GO:0006629,GO:0006869,GO:0006953,GO:0008035,GO:0008203,GO:0008289,GO:0016020,GO:0042157,GO:0060135","signaling receptor binding|protein binding|extracellular region|endoplasmic reticulum membrane|lipid metabolic process|lipid transport|acute-phase response|high-density lipoprotein particle binding|cholesterol metabolic process|lipid binding|membrane|lipoprotein metabolic process|maternal process involved in female pregnancy"]
["APOL3",0.524705566376784,0.72630639622614,0.772960867410021,0.732332915364918,0.662784638778476,0.584860885154079,0.839789529302391,0.857541070914346,0.407637023352861,0.353340238902085,0.397171299190697,0.433476723203752,0.389455876061056,0.630386914175096,0.507809552199333,0.497500580772126,1.12378453191821,1.2235966666928,0.756985872947181,0.906581529024362,0.970356618857561,0.863692452936588,0.699089305126096,0.796024290744713,1.08693298821024,1.24033160564907,0.631588900526412,0.810108589018442,80833,"apolipoprotein L3","protein_coding",null,null,"GO:0005319,GO:0005576,GO:0005737,GO:0006869,GO:0006954,GO:0008289,GO:0016020,GO:0042157,GO:0043123","lipid transporter activity|extracellular region|cytoplasm|lipid transport|inflammatory response|lipid binding|membrane|lipoprotein metabolic process|positive regulation of canonical NF-kappaB signal transduction"]
["APOL4",0,0.00666489031974851,0.0394709535146606,0.0268807686883106,0,0.0460599996670958,0.0261501485648905,0.020613345947521,0.0422890019657159,0.0202461323195568,0.0790769805542616,0.0281987961705998,0.0333183281457116,0.140288139269176,0.0521323199952493,0.026575083698619,0.0134737551816681,0.0259335966419809,0.0777130512599629,0.0134763027002411,0.00661363920429556,0.00666048248083843,0.00691752502981795,6.84571984862869E-3,0.0555758101669038,0,0.0135612344137997,0.00658746068558956,80832,"apolipoprotein L4","protein_coding",null,null,"GO:0003674,GO:0005615,GO:0006629,GO:0006869,GO:0008289,GO:0042157,GO:0043231","molecular_function|extracellular space|lipid metabolic process|lipid transport|lipid binding|lipoprotein metabolic process|intracellular membrane-bounded organelle"]
["APOL5",0.045122556470109,0,0,0,0,0.00847447600168911,0,0,0,0,0,0.0453970408722369,0,0,0,0,0.00867652095478359,0,0.00834064580395819,0.00867816144757742,0,0,0,0,0,0.00857490893665197,0,0,80831,"apolipoprotein L5","protein_coding",null,null,"GO:0005575,GO:0005576,GO:0005737,GO:0006629,GO:0006869,GO:0008035,GO:0008289,GO:0042157","cellular_component|extracellular region|cytoplasm|lipid metabolic process|lipid transport|high-density lipoprotein particle binding|lipid binding|lipoprotein metabolic process"]
["APOL6",3.7138628901765,3.3833442694162,3.24869852980206,2.51407184640689,4.12958641192188,3.70839010893499,3.36746357697629,2.95239713731661,3.72775597920416,2.20757500795795,2.38661915043201,3.01335469078604,3.92455469510523,3.53822188015966,3.7504039780701,4.08382305209405,3.4399898698724,2.63587200521266,2.18361568264945,3.04103340848707,3.28825665456923,3.25937690984744,3.21487314446172,3.69217667603233,3.67682762615668,2.42871450726355,2.75670811426107,2.26785245691665,80830,"apolipoprotein L6","protein_coding",null,null,"GO:0005515,GO:0005576,GO:0005737,GO:0006869,GO:0008289,GO:0042157","protein binding|extracellular region|cytoplasm|lipid transport|lipid binding|lipoprotein metabolic process"]
["APOLD1",2.06660552494742,1.49843180221203,1.44720077435607,1.55960260460055,2.30630920547148,1.71795060341908,1.02201123673292,1.43405818613108,1.5107673610362,1.29430772978171,1.00893271534224,1.08503492112718,1.47130777943759,1.52344881511453,1.32329715190287,1.35984102089973,1.85119772085275,2.2778704534364,1.2942082605934,2.20991180881292,2.22236979427979,2.12539986114349,1.58867613218836,2.01350057688546,2.37356671779224,1.94218633928533,1.69383340226907,1.5924986127438,81575,"apolipoprotein L domain containing 1","protein_coding",null,null,"GO:0001525,GO:0005576,GO:0005886,GO:0006869,GO:0008289,GO:0030154,GO:0042157,GO:0045601","angiogenesis|extracellular region|plasma membrane|lipid transport|lipid binding|cell differentiation|lipoprotein metabolic process|regulation of endothelial cell differentiation","WP3888","VEGFA-VEGFR2 signaling"]
["APOM",2.97224643969383,1.679465047603,2.90096426636543,3.4996941391505,2.04167466839227,1.79624660273793,2.82799154407772,2.59714656747096,2.2200571856183,2.29579205010922,3.09965649104179,2.54621891994366,2.57470654380848,3.28257180270936,2.32628383963517,2.90184827696864,2.43323368548768,1.79710481839308,2.47503200927347,2.09410856992316,1.52767123476078,2.06997034026214,3.13762623284786,2.4437949365746,2.30488689891569,3.15971352434178,2.73380273134782,3.2092440020368,55937,"apolipoprotein M","protein_coding",null,null,"GO:0005319,GO:0005543,GO:0005576,GO:0016209,GO:0033344,GO:0034361,GO:0034362,GO:0034364,GO:0034365,GO:0034366,GO:0034375,GO:0034380,GO:0034384,GO:0034445,GO:0042157,GO:0042632,GO:0043691,GO:0098869","lipid transporter activity|phospholipid binding|extracellular region|antioxidant activity|cholesterol efflux|very-low-density lipoprotein particle|low-density lipoprotein particle|high-density lipoprotein particle|discoidal high-density lipoprotein particle|spherical high-density lipoprotein particle|high-density lipoprotein particle remodeling|high-density lipoprotein particle assembly|high-density lipoprotein particle clearance|negative regulation of plasma lipoprotein oxidation|lipoprotein metabolic process|cholesterol homeostasis|reverse cholesterol transport|cellular oxidant detoxification","WP5115,WP5323","Network map of SARS-CoV-2 signaling pathway|Fatty Acids and Lipoproteins Transport in Hepatocytes","R-HSA-1430728,R-HSA-196854,R-HSA-2187338,R-HSA-6806667,R-HSA-9709957,R-HSA-975634","Metabolism|Metabolism of vitamins and cofactors|Visual phototransduction|Metabolism of fat-soluble vitamins|Sensory Perception|Retinoid metabolism and transport"]
["APOO",4.89294329993833,4.8681420230984,4.52321523504627,4.87974631288873,4.73717965422288,4.07323612868937,4.24299628665472,5.23953914294736,5.38964617953535,3.98975063199712,5.39197722167025,4.45459727396265,5.43818561152189,3.84919394701804,4.67603471132221,3.91348071017004,6.58020392534743,6.01321193485195,7.58780035188388,6.06186005703996,6.81398901954506,5.90638680788818,7.54196261913264,7.99155841894913,6.44316963817721,6.71706133634194,6.82626178486836,6.68824589979815,79135,"apolipoprotein O","protein_coding",null,null,"GO:0000139,GO:0001401,GO:0005515,GO:0005576,GO:0005615,GO:0005739,GO:0005743,GO:0005789,GO:0005829,GO:0006869,GO:0007007,GO:0034361,GO:0034362,GO:0034364,GO:0042407,GO:0044284,GO:0061617,GO:0140275","Golgi membrane|SAM complex|protein binding|extracellular region|extracellular space|mitochondrion|mitochondrial inner membrane|endoplasmic reticulum membrane|cytosol|lipid transport|inner mitochondrial membrane organization|very-low-density lipoprotein particle|low-density lipoprotein particle|high-density lipoprotein particle|cristae formation|mitochondrial crista junction|MICOS complex|MIB complex","WP5323","Fatty Acids and Lipoproteins Transport in Hepatocytes","R-HSA-1592230,R-HSA-1852241,R-HSA-8949613","Mitochondrial biogenesis|Organelle biogenesis and maintenance|Cristae formation"]
["APOOL",2.9105949245939,2.50424892791031,2.36596024031717,1.88025778259761,3.08800416278406,2.5630809671381,2.1446529231308,2.45146433169705,2.49033654907649,1.68274104084366,1.71125215520328,2.08585707762743,2.84451842962302,2.2183815261578,2.71806868701037,2.53830050580237,2.63580033909948,2.10454370703259,2.36633687790398,3.08148863831472,2.92575506490027,2.25386410172186,3.77953174567113,2.86716965708554,2.57830965400991,1.94700504388198,2.67628713102246,2.07398368714004,139322,"apolipoprotein O like","protein_coding",null,null,"GO:0001401,GO:0005515,GO:0005576,GO:0005739,GO:0005743,GO:0007007,GO:0031093,GO:0042407,GO:0044284,GO:0061617,GO:0140275","SAM complex|protein binding|extracellular region|mitochondrion|mitochondrial inner membrane|inner mitochondrial membrane organization|platelet alpha granule lumen|cristae formation|mitochondrial crista junction|MICOS complex|MIB complex",null,null,"R-HSA-109582,R-HSA-114608,R-HSA-1592230,R-HSA-1852241,R-HSA-76002,R-HSA-76005,R-HSA-8949613","Hemostasis|Platelet degranulation |Mitochondrial biogenesis|Organelle biogenesis and maintenance|Platelet activation, signaling and aggregation|Response to elevated platelet cytosolic Ca2+|Cristae formation"]
["APP",204.183171029365,210.175767232378,196.813189066401,173.653983575744,219.618705823027,216.453811897865,208.346113155595,202.266963764636,203.90906186409,201.866592210853,167.346876996709,182.666078583696,225.299226402183,201.895662201321,230.522612302922,235.177528606536,148.292100441637,145.776972336992,136.842768996991,162.029965470373,141.558413291225,136.831308721069,133.379539300786,142.211614991442,153.581559084129,126.82421526342,130.117132623823,125.258055742917,351,"amyloid beta precursor protein","protein_coding","hsa04726,hsa05010,hsa05022","Serotonergic synapse|Alzheimer disease|Pathways of neurodegeneration - multiple diseases","GO:0000086,GO:0000978,GO:0001774,GO:0001934,GO:0001967,GO:0002265,GO:0003677,GO:0004867,GO:0005102,GO:0005515,GO:0005576,GO:0005615,GO:0005641,GO:0005737,GO:0005768,GO:0005769,GO:0005783,GO:0005788,GO:0005790,GO:0005794,GO:0005796,GO:0005798,GO:0005829,GO:0005886,GO:0005905,GO:0005911,GO:0006378,GO:0006417,GO:0006468,GO:0006878,GO:0006897,GO:0006979,GO:0007155,GO:0007176,GO:0007219,GO:0007409,GO:0007417,GO:0007611,GO:0007612,GO:0007617,GO:0007626,GO:0008021,GO:0008088,GO:0008201,GO:0008203,GO:0008285,GO:0008344,GO:0008542,GO:0009986,GO:0010468,GO:0010628,GO:0010629,GO:0010800,GO:0010971,GO:0014005,GO:0016020,GO:0016199,GO:0016322,GO:0016358,GO:0019899,GO:0030111,GO:0030134,GO:0030198,GO:0030424,GO:0030426,GO:0030546,GO:0030900,GO:0031093,GO:0031175,GO:0031594,GO:0031904,GO:0032092,GO:0032588,GO:0032722,GO:0032731,GO:0032755,GO:0032760,GO:0033138,GO:0035235,GO:0035253,GO:0040014,GO:0042802,GO:0043197,GO:0043198,GO:0043204,GO:0043235,GO:0045121,GO:0045177,GO:0045202,GO:0045665,GO:0045821,GO:0045931,GO:0045944,GO:0046330,GO:0046914,GO:0048018,GO:0048143,GO:0048169,GO:0048471,GO:0048669,GO:0048786,GO:0050729,GO:0050730,GO:0050803,GO:0050808,GO:0050885,GO:0050890,GO:0051091,GO:0051124,GO:0051233,GO:0051247,GO:0051402,GO:0051425,GO:0051563,GO:0055037,GO:0070050,GO:0070062,GO:0070374,GO:0070555,GO:0098815,GO:0150003,GO:0180011,GO:1900272,GO:1900273,GO:1901224,GO:1904646,GO:1905598,GO:1905606,GO:1905908,GO:1990000,GO:1990535,GO:2000310,GO:2000406","G2/M transition of mitotic cell cycle|RNA polymerase II cis-regulatory region sequence-specific DNA binding|microglial cell activation|positive regulation of protein phosphorylation|suckling behavior|astrocyte activation involved in immune response|DNA binding|serine-type endopeptidase inhibitor activity|signaling receptor binding|protein binding|extracellular region|extracellular space|nuclear envelope lumen|cytoplasm|endosome|early endosome|endoplasmic reticulum|endoplasmic reticulum lumen|smooth endoplasmic reticulum|Golgi apparatus|Golgi lumen|Golgi-associated vesicle|cytosol|plasma membrane|clathrin-coated pit|cell-cell junction|mRNA polyadenylation|regulation of translation|protein phosphorylation|intracellular copper ion homeostasis|endocytosis|response to oxidative stress|cell adhesion|regulation of epidermal growth factor-activated receptor activity|Notch signaling pathway|axonogenesis|central nervous system development|learning or memory|learning|mating behavior|locomotory behavior|synaptic vesicle|axo-dendritic transport|heparin binding|cholesterol metabolic process|negative regulation of cell population proliferation|adult locomotory behavior|visual learning|cell surface|regulation of gene expression|positive regulation of gene expression|negative regulation of gene expression|positive regulation of peptidyl-threonine phosphorylation|positive regulation of G2/M transition of mitotic cell cycle|microglia development|membrane|axon midline choice point recognition|neuron remodeling|dendrite development|enzyme binding|regulation of Wnt signaling pathway|COPII-coated ER to Golgi transport vesicle|extracellular matrix organization|axon|growth cone|signaling receptor activator activity|forebrain development|platelet alpha granule lumen|neuron projection development|neuromuscular junction|endosome lumen|positive regulation of protein binding|trans-Golgi network membrane|positive regulation of chemokine production|positive regulation of interleukin-1 beta production|positive regulation of interleukin-6 production|positive regulation of tumor necrosis factor production|positive regulation of peptidyl-serine phosphorylation|ionotropic glutamate receptor signaling pathway|ciliary rootlet|regulation of multicellular organism growth|identical protein binding|dendritic spine|dendritic shaft|perikaryon|receptor complex|membrane raft|apical part of cell|synapse|negative regulation of neuron differentiation|positive regulation of glycolytic process|positive regulation of mitotic cell cycle|positive regulation of transcription by RNA polymerase II|positive regulation of JNK cascade|transition metal ion binding|receptor ligand activity|astrocyte activation|regulation of long-term neuronal synaptic plasticity|perinuclear region of cytoplasm|collateral sprouting in absence of injury|presynaptic active zone|positive regulation of inflammatory response|regulation of peptidyl-tyrosine phosphorylation|regulation of synapse structure or activity|synapse organization|neuromuscular process controlling balance|cognition|positive regulation of DNA-binding transcription factor activity|synaptic assembly at neuromuscular junction|spindle midzone|positive regulation of protein metabolic process|neuron apoptotic process|PTB domain binding|smooth endoplasmic reticulum calcium ion homeostasis|recycling endosome|neuron cellular homeostasis|extracellular exosome|positive regulation of ERK1 and ERK2 cascade|response to interleukin-1|modulation of excitatory postsynaptic potential|regulation of spontaneous synaptic transmission|cytoplasmic polyadenylation|negative regulation of long-term synaptic potentiation|positive regulation of long-term synaptic potentiation|positive regulation of non-canonical NF-kappaB signal transduction|cellular response to amyloid-beta|negative regulation of low-density lipoprotein receptor activity|regulation of presynapse assembly|positive regulation of amyloid fibril formation|amyloid fibril formation|neuron projection maintenance|regulation of NMDA receptor activity|positive regulation of T cell migration","WP5124,WP3286,WP4549,WP2864,WP2853,WP5120,WP5323,WP2059,WP5180,WP5265,WP5381,WP5372,WP5407","Alzheimer's disease|Copper homeostasis|Fragile X syndrome|Apoptosis-related network due to altered Notch3 in ovarian cancer|Endoderm differentiation|Inclusion body myositis|Fatty Acids and Lipoproteins Transport in Hepatocytes|Alzheimer's disease and miRNA effects|DYRK1A involvement regarding cell proliferation in brain development|Neurogenesis regulation in the olfactory epithelium|Smith-Magenis and Potocki-Lupski syndrome copy number variation|Involvement of ??-secretase in neurodegenerative diseases|15q11q13 copy number variation","R-HSA-109582,R-HSA-114608,R-HSA-1280215,R-HSA-1474244,R-HSA-162582,R-HSA-1643685,R-HSA-166016,R-HSA-166058,R-HSA-166166,R-HSA-168138,R-HSA-168142,R-HSA-168164,R-HSA-168176,R-HSA-168179,R-HSA-168181,R-HSA-168188,R-HSA-168249,R-HSA-168249,R-HSA-168256,R-HSA-168256,R-HSA-168643,R-HSA-168898,R-HSA-168928,R-HSA-181438,R-HSA-199991,R-HSA-199992,R-HSA-3000178,R-HSA-372790,R-HSA-373076,R-HSA-375276,R-HSA-381426,R-HSA-388396,R-HSA-392499,R-HSA-416476,R-HSA-418594,R-HSA-432720,R-HSA-444473,R-HSA-445989,R-HSA-446652,R-HSA-449147,R-HSA-500792,R-HSA-5653656,R-HSA-5663205,R-HSA-597592,R-HSA-622312,R-HSA-76002,R-HSA-76005,R-HSA-844456,R-HSA-879415,R-HSA-879415,R-HSA-8862803,R-HSA-8863678,R-HSA-8957275,R-HSA-9020702,R-HSA-933542,R-HSA-937061,R-HSA-9609507,R-HSA-9609507,R-HSA-9609523,R-HSA-9609523,R-HSA-9645723,R-HSA-9658195,R-HSA-9660826,R-HSA-9664424,R-HSA-9734009,R-HSA-975138,R-HSA-975155,R-HSA-975871,R-HSA-977225,R-HSA-9824443","Hemostasis|Platelet degranulation |Cytokine Signaling in Immune system|Extracellular matrix organization|Signal Transduction|Disease|Toll Like Receptor 4 (TLR4) Cascade|MyD88:MAL(TIRAP) cascade initiated on plasma membrane|MyD88-independent TLR4 cascade |Toll Like Receptor 9 (TLR9) Cascade|Toll Like Receptor 10 (TLR10) Cascade|Toll Like Receptor 3 (TLR3) Cascade|Toll Like Receptor 5 (TLR5) Cascade|Toll Like Receptor TLR1:TLR2 Cascade|Toll Like Receptor 7/8 (TLR7/8) Cascade|Toll Like Receptor TLR6:TLR2 Cascade|Innate Immune System|Innate Immune System|Immune System|Immune System|Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways|Toll-like Receptor Cascades|DDX58/IFIH1-mediated induction of interferon-alpha/beta|Toll Like Receptor 2 (TLR2) Cascade|Membrane Trafficking|trans-Golgi Network Vesicle Budding|ECM proteoglycans|Signaling by GPCR|Class A/1 (Rhodopsin-like receptors)|Peptide ligand-binding receptors|Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)|GPCR downstream signalling|Metabolism of proteins|G alpha (q) signalling events|G alpha (i) signalling events|Lysosome Vesicle Biogenesis|Formyl peptide receptors bind formyl peptides and many other ligands|TAK1-dependent IKK and NF-kappa-B activation  |Interleukin-1 family signaling|Signaling by Interleukins|GPCR ligand binding|Vesicle-mediated transport|Infectious disease|Post-translational protein modification|Inflammasomes|Platelet activation, signaling and aggregation|Response to elevated platelet cytosolic Ca2+|The NLRP3 inflammasome|Advanced glycosylation endproduct receptor signaling|Advanced glycosylation endproduct receptor signaling|Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models|Neurodegenerative Diseases|Post-translational protein phosphorylation|Interleukin-1 signaling|TRAF6 mediated NF-kB activation|TRIF(TICAM1)-mediated TLR4 signaling |Protein localization|Protein localization|Insertion of tail-anchored proteins into the endoplasmic reticulum membrane|Insertion of tail-anchored proteins into the endoplasmic reticulum membrane|Diseases of programmed cell death|Leishmania infection|Purinergic signaling in leishmaniasis infection|Cell recruitment (pro-inflammatory response)|Defective Intrinsic Pathway for Apoptosis|TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation|MyD88 dependent cascade initiated on endosome|MyD88 cascade initiated on plasma membrane|Amyloid fiber formation|Parasitic Infection Pathways"]
["APPBP2",10.1715335895312,9.69837483282988,9.26648332788719,7.89829949089366,11.3631131450266,9.84619907125501,8.91993581399211,8.57762783060645,10.4387972810909,5.93594172806378,7.18595107069734,8.55137454440369,11.3414803246511,9.09910119396795,10.2695131830611,9.80463396655482,8.32273548067308,7.78423511952933,7.98529469699442,9.29289821730507,9.24975476645145,8.09102152006211,10.8892056058352,9.36059095896826,8.55773538131617,7.79380301663702,9.35545950275013,7.34257131686372,10513,"amyloid beta precursor protein binding protein 2","protein_coding",null,null,"GO:0003777,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005874,GO:0005875,GO:0006886,GO:0016567,GO:0030659,GO:0031462,GO:0043161,GO:0046907,GO:1990756","microtubule motor activity|protein binding|nucleus|nucleoplasm|cytoplasm|microtubule|microtubule associated complex|intracellular protein transport|protein ubiquitination|cytoplasmic vesicle membrane|Cul2-RING ubiquitin ligase complex|proteasome-mediated ubiquitin-dependent protein catabolic process|intracellular transport|ubiquitin ligase-substrate adaptor activity"]
["APPBP2-DT",0.184211038054053,0.0584050866972039,0.172943915912186,0.647786724705719,0.360006544242162,0.288305920467487,0.343734469917313,0.180636769613014,0.617637777380824,0.591396135408771,0.404226273603969,0.123554406455919,0.291971773067318,0.351245344463731,0.285525391545734,0.407540107585486,0.177107754614614,0.113629323783258,0.9080094402341,0.413329561975845,0.289779840762243,0.175099381119262,0.788046342292085,0.479917708568102,0.0608770335171067,0.0583445398491559,0.71303055293696,0.173179689686535,120017341,null,"non_coding"]
["APPL1",6.69172744693279,6.6706278073976,6.78254799277167,5.11731603700982,7.0981202112747,6.57739610794041,6.84711616401544,5.75028525002292,7.92217538558477,5.34679864843136,5.78807207225158,6.95389544027547,8.7083215882159,6.7784767963585,9.52323941410522,7.93514182693553,6.17972912203663,6.16310568856007,6.76648138074663,8.301876764056,6.79385358173157,6.49464375519762,9.87888891213622,8.0430108707907,6.54704010632284,5.76434143809049,8.18805097290249,5.89367186520127,26060,"adaptor protein%2C phosphotyrosine interacting with PH domain and leucine zipper 1","protein_coding","hsa04211,hsa05200,hsa05210","Longevity regulating pathway|Pathways in cancer|Colorectal cancer","GO:0001726,GO:0001786,GO:0005515,GO:0005634,GO:0005737,GO:0005768,GO:0005769,GO:0005829,GO:0005886,GO:0006606,GO:0007049,GO:0007165,GO:0007179,GO:0008286,GO:0010008,GO:0010762,GO:0012506,GO:0016020,GO:0023052,GO:0031410,GO:0031901,GO:0032009,GO:0033211,GO:0034143,GO:0035091,GO:0035729,GO:0042802,GO:0042803,GO:0043422,GO:0044354,GO:0044877,GO:0045088,GO:0046324,GO:0046326,GO:0048023,GO:0048487,GO:0070062,GO:0097708,GO:0098793,GO:0098794,GO:0098978,GO:0099558,GO:1900017,GO:1903076,GO:1905303,GO:1905450,GO:2000045","ruffle|phosphatidylserine binding|protein binding|nucleus|cytoplasm|endosome|early endosome|cytosol|plasma membrane|protein import into nucleus|cell cycle|signal transduction|transforming growth factor beta receptor signaling pathway|insulin receptor signaling pathway|endosome membrane|regulation of fibroblast migration|vesicle membrane|membrane|signaling|cytoplasmic vesicle|early endosome membrane|early phagosome|adiponectin-activated signaling pathway|regulation of toll-like receptor 4 signaling pathway|phosphatidylinositol binding|cellular response to hepatocyte growth factor stimulus|identical protein binding|protein homodimerization activity|protein kinase B binding|macropinosome|protein-containing complex binding|regulation of innate immune response|regulation of glucose import|positive regulation of glucose import|positive regulation of melanin biosynthetic process|beta-tubulin binding|extracellular exosome|intracellular vesicle|presynapse|postsynapse|glutamatergic synapse|maintenance of synapse structure|positive regulation of cytokine production involved in inflammatory response|regulation of protein localization to plasma membrane|positive regulation of macropinocytosis|negative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis|regulation of G1/S transition of mitotic cell cycle","WP4216,WP2035","Chromosomal and microsatellite instability in colorectal cancer |Follicle stimulating hormone (FSH) signaling pathway","R-HSA-109581,R-HSA-418889,R-HSA-5357769,R-HSA-5357801","Apoptosis|Caspase activation via Dependence Receptors in the absence of ligand|Caspase activation via extrinsic apoptotic signalling pathway|Programmed Cell Death"]
["APPL2",8.23153447570773,8.36081512828452,7.41572754654074,6.95490584052254,8.02561464058601,7.62665131036659,7.58028171735038,7.09015001006223,8.89687917136534,8.21316114383826,8.59664087839458,10.2406975819681,8.24608023998611,7.50440265210393,7.8880333492608,7.30989471504677,8.5596934470318,9.12719309280052,8.41451510371266,8.9604679742605,8.2072199823276,8.60188265938902,9.38280030696965,8.92758603571985,8.43024222726805,7.93454032959472,9.08486931599265,8.17473365291125,55198,"adaptor protein%2C phosphotyrosine interacting with PH domain and leucine zipper 2","protein_coding",null,null,"GO:0001726,GO:0001786,GO:0002024,GO:0005515,GO:0005634,GO:0005768,GO:0005886,GO:0006606,GO:0007049,GO:0007165,GO:0007179,GO:0009631,GO:0010008,GO:0010762,GO:0016020,GO:0023052,GO:0031410,GO:0031901,GO:0031982,GO:0032009,GO:0032587,GO:0033211,GO:0034143,GO:0035091,GO:0035729,GO:0036186,GO:0042593,GO:0042802,GO:0042803,GO:0044354,GO:0044877,GO:0045088,GO:0046322,GO:0046325,GO:0050768,GO:0051289,GO:0060100,GO:0070062,GO:0120162,GO:1900016,GO:1900077,GO:1905303,GO:1905451,GO:2000045,GO:2000178","ruffle|phosphatidylserine binding|diet induced thermogenesis|protein binding|nucleus|endosome|plasma membrane|protein import into nucleus|cell cycle|signal transduction|transforming growth factor beta receptor signaling pathway|cold acclimation|endosome membrane|regulation of fibroblast migration|membrane|signaling|cytoplasmic vesicle|early endosome membrane|vesicle|early phagosome|ruffle membrane|adiponectin-activated signaling pathway|regulation of toll-like receptor 4 signaling pathway|phosphatidylinositol binding|cellular response to hepatocyte growth factor stimulus|early phagosome membrane|glucose homeostasis|identical protein binding|protein homodimerization activity|macropinosome|protein-containing complex binding|regulation of innate immune response|negative regulation of fatty acid oxidation|negative regulation of glucose import|negative regulation of neurogenesis|protein homotetramerization|positive regulation of phagocytosis, engulfment|extracellular exosome|positive regulation of cold-induced thermogenesis|negative regulation of cytokine production involved in inflammatory response|negative regulation of cellular response to insulin stimulus|positive regulation of macropinocytosis|positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis|regulation of G1/S transition of mitotic cell cycle|negative regulation of neural precursor cell proliferation"]
["APRG1",0.0705660084692228,0.0671199818326506,0.062109276084301,0.0972855568680634,0.0775733996673637,0.0372741064059895,0.0411484054029507,0.0864960098823227,0.0665435988882972,0.0934506524178324,0.0580678449319838,0.0576836549119709,0.0503307362735155,0.0714808029486482,0.0451178702805744,0.0334536475747996,0.029682162408961,0.0367268863111627,0.0244569787464886,0.0720988809140271,0.0624411077035136,0.0377300204407835,0.030478081074602,0.0258528968498114,0.0480980358072821,0.0460971503487523,0.059749751559099,0.0248775797684519,339883,"APRG1 tumor suppressor candidate","non_coding",null,null,"GO:0016020","membrane"]
["APRT",62.5696897135986,56.0991836126399,64.8044939991807,76.3636874720221,57.4624194244915,63.3783121735045,67.264516006322,69.3054714216029,52.4520423921157,59.6491289438969,66.1134803167534,63.6494307135418,47.8283634264387,61.2259746500222,50.8383633352598,54.658588843791,59.0991392687278,62.6889683939795,70.5659755921673,54.9617326675465,57.1161980016684,62.2820285959897,54.1952941195376,57.3383744256782,52.3879240902986,69.0539903484279,59.1466247129176,68.9214241717469,353,"adenine phosphoribosyltransferase","protein_coding","hsa00230","Purine metabolism","GO:0002055,GO:0003999,GO:0005515,GO:0005576,GO:0005654,GO:0005737,GO:0005829,GO:0006166,GO:0006168,GO:0007625,GO:0016208,GO:0032263,GO:0032264,GO:0034774,GO:0044209,GO:0070062","adenine binding|adenine phosphoribosyltransferase activity|protein binding|extracellular region|nucleoplasm|cytoplasm|cytosol|purine ribonucleoside salvage|adenine salvage|grooming behavior|AMP binding|GMP salvage|IMP salvage|secretory granule lumen|AMP salvage|extracellular exosome","WP4792,WP4224","Purine metabolism|Purine metabolism and related disorders","R-HSA-1430728,R-HSA-15869,R-HSA-1643685,R-HSA-168249,R-HSA-168256,R-HSA-5668914,R-HSA-6798695,R-HSA-74217,R-HSA-8956321,R-HSA-9734195,R-HSA-9734207,R-HSA-9735804","Metabolism|Metabolism of nucleotides|Disease|Innate Immune System|Immune System|Diseases of metabolism|Neutrophil degranulation|Purine salvage|Nucleotide salvage|Defective APRT disrupts adenine salvage|Nucleotide salvage defects|Diseases of nucleotide metabolism"]
["APTR",1.72182556896199,1.44066912502925,2.03908501121801,1.74040687480509,1.51494405089411,1.66384533120255,1.71976559465389,1.70242854245141,1.50195822190479,1.30740396645761,1.51849250347749,1.68917179194605,1.83447729984994,1.40315052041845,1.66108728980357,1.61222996178663,1.79968015904794,1.54687064868261,1.93470928751974,1.7038361315904,1.24077691054391,1.74531650110598,1.69982089274318,1.71707636559447,1.55122684319325,1.61567829645362,2.14321777429964,1.6254319173883,100505854,"Alu-mediated CDKN1A/p21 transcriptional regulator","non_coding"]
["APTX",12.0646731109046,10.9089327176937,13.1940014590444,13.1296245362519,12.0751857963112,11.9455832844483,12.6314693324502,12.751287130565,11.2620812567652,8.7610575282191,11.90631294685,12.1786930592779,10.129233470956,10.4626604032884,11.8209864743609,10.3670222648539,13.2107570685874,11.508650282683,12.1395038315979,11.2133059257379,10.9393951991482,12.2740294145099,11.9503561156786,12.5759334938333,12.3915999737618,12.7778475609416,12.514954704091,12.443187718552,54840,"aprataxin","protein_coding","hsa03410","Base excision repair","GO:0000012,GO:0000785,GO:0003682,GO:0003684,GO:0003690,GO:0003697,GO:0003725,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0006266,GO:0008967,GO:0030983,GO:0031647,GO:0033699,GO:0046872,GO:0051219,GO:0120108,GO:1990165","single strand break repair|chromatin|chromatin binding|damaged DNA binding|double-stranded DNA binding|single-stranded DNA binding|double-stranded RNA binding|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|DNA ligation|phosphoglycolate phosphatase activity|mismatched DNA binding|regulation of protein stability|DNA 5'-adenosine monophosphate hydrolase activity|metal ion binding|phosphoprotein binding|DNA-3'-diphospho-5'-guanosine diphosphatase|single-strand break-containing DNA binding","WP5037","Riboflavin and CoQ disorders"]
["AQP1",1.48777949010782,1.11720405490512,0.735147703562814,1.46441625585087,2.58239988435145,1.32356914076054,1.01366721039704,1.28614604324076,1.28975057877247,1.02755615379248,0.819251205310752,0.777957583568945,1.03322385837308,1.15712851435655,0.628093655432959,0.816686867737446,1.02575443791623,0.760747084936716,0.560870573354478,0.762402007173934,0.99775176544804,0.874564398604151,0.328539738144563,0.592883087863407,1.08685620332937,0.930038235068244,0.312565771616973,0.726948053500211,358,"aquaporin 1 (Colton blood group)","protein_coding","hsa04924,hsa04976,hsa04964","Renin secretion|Bile secretion|Proximal tubule bicarbonate reclamation","GO:0003091,GO:0003094,GO:0003097,GO:0005223,GO:0005267,GO:0005372,GO:0005515,GO:0005634,GO:0005737,GO:0005886,GO:0005903,GO:0006813,GO:0006833,GO:0006884,GO:0006972,GO:0008519,GO:0009925,GO:0009992,GO:0010761,GO:0010763,GO:0015079,GO:0015168,GO:0015250,GO:0015670,GO:0015793,GO:0016323,GO:0016324,GO:0019233,GO:0019725,GO:0019934,GO:0021670,GO:0022857,GO:0030157,GO:0030184,GO:0030185,GO:0030424,GO:0030950,GO:0031526,GO:0031965,GO:0033326,GO:0033363,GO:0034644,GO:0035377,GO:0035378,GO:0035379,GO:0042060,GO:0042383,GO:0042476,GO:0042802,GO:0043066,GO:0043154,GO:0044241,GO:0045177,GO:0045766,GO:0046875,GO:0046878,GO:0048146,GO:0048593,GO:0050829,GO:0050891,GO:0051458,GO:0051649,GO:0070062,GO:0070295,GO:0070301,GO:0071241,GO:0071260,GO:0071280,GO:0071288,GO:0071300,GO:0071320,GO:0071456,GO:0071472,GO:0071474,GO:0071549,GO:0071732,GO:0071805,GO:0072220,GO:0072230,GO:0072232,GO:0072239,GO:0072488,GO:0170014","renal water homeostasis|glomerular filtration|renal water transport|intracellular cGMP-activated cation channel activity|potassium channel activity|water transmembrane transporter activity|protein binding|nucleus|cytoplasm|plasma membrane|brush border|potassium ion transport|water transport|cell volume homeostasis|hyperosmotic response|ammonium transmembrane transporter activity|basal plasma membrane|intracellular water homeostasis|fibroblast migration|positive regulation of fibroblast migration|potassium ion transmembrane transporter activity|glycerol transmembrane transporter activity|water channel activity|carbon dioxide transport|glycerol transmembrane transport|basolateral plasma membrane|apical plasma membrane|sensory perception of pain|cellular homeostasis|cGMP-mediated signaling|lateral ventricle development|transmembrane transporter activity|pancreatic juice secretion|nitric oxide transmembrane transporter activity|nitric oxide transport|axon|establishment or maintenance of actin cytoskeleton polarity|brush border membrane|nuclear membrane|cerebrospinal fluid secretion|secretory granule organization|cellular response to UV|transepithelial water transport|carbon dioxide transmembrane transport|carbon dioxide transmembrane transporter activity|wound healing|sarcolemma|odontogenesis|identical protein binding|negative regulation of apoptotic process|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|lipid digestion|apical part of cell|positive regulation of angiogenesis|ephrin receptor binding|positive regulation of saliva secretion|positive regulation of fibroblast proliferation|camera-type eye morphogenesis|defense response to Gram-negative bacterium|multicellular organismal-level water homeostasis|corticotropin secretion|establishment of localization in cell|extracellular exosome|renal water absorption|cellular response to hydrogen peroxide|cellular response to inorganic substance|cellular response to mechanical stimulus|cellular response to copper ion|cellular response to mercury ion|cellular response to retinoic acid|cellular response to cAMP|cellular response to hypoxia|cellular response to salt stress|cellular hyperosmotic response|cellular response to dexamethasone stimulus|cellular response to nitric oxide|potassium ion transmembrane transport|metanephric descending thin limb development|metanephric proximal straight tubule development|metanephric proximal convoluted tubule segment 2 development|metanephric glomerulus vasculature development|ammonium transmembrane transport|ankyrin-1 complex","WP4917,WP2431","Proximal tubule transport|Spinal cord injury","R-HSA-1237044,R-HSA-1247673,R-HSA-1480926,R-HSA-382551,R-HSA-432040,R-HSA-432047,R-HSA-445717","Erythrocytes take up carbon dioxide and release oxygen|Erythrocytes take up oxygen and release carbon dioxide|O2/CO2 exchange in erythrocytes|Transport of small molecules|Vasopressin regulates renal water homeostasis via Aquaporins|Passive transport by Aquaporins|Aquaporin-mediated transport"]
["AQP10",0,0,0,0,0,0,0,0.0142804865586374,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,89872,"aquaporin 10","protein_coding",null,null,"GO:0005515,GO:0005811,GO:0005886,GO:0006833,GO:0009636,GO:0015204,GO:0015250,GO:0015254,GO:0015793,GO:0016323,GO:0016324,GO:0043231,GO:0051289,GO:0071468,GO:0071918","protein binding|lipid droplet|plasma membrane|water transport|response to toxic substance|urea transmembrane transporter activity|water channel activity|glycerol channel activity|glycerol transmembrane transport|basolateral plasma membrane|apical plasma membrane|intracellular membrane-bounded organelle|protein homotetramerization|cellular response to acidic pH|urea transmembrane transport",null,null,"R-HSA-382551,R-HSA-432047,R-HSA-445717","Transport of small molecules|Passive transport by Aquaporins|Aquaporin-mediated transport"]
["AQP11",0.690431670875436,1.02000425797563,0.579244309098798,0.63398695796688,0.760787671651442,0.758708059911441,0.822340230483383,0.504175107194182,0.354628426293426,0.212225806630341,0.179596679132569,0.4286024928039,0.349252338900688,0.364133911145234,0.355202923062999,0.278567702966178,0.112988634733247,0.326212140430629,0.298690571314064,0.409661242001907,0.332765166460054,0.432866026821443,0.188529887883501,0.430552876147268,0.233024677615344,0.223330816294534,0.213229163991366,0.345258327758352,282679,"aquaporin 11","protein_coding",null,null,"GO:0005737,GO:0005783,GO:0005789,GO:0005886,GO:0006486,GO:0006612,GO:0006811,GO:0006833,GO:0008284,GO:0009986,GO:0009992,GO:0015250,GO:0015254,GO:0015267,GO:0015793,GO:0015840,GO:0030659,GO:0032364,GO:0043231,GO:0048388,GO:0048471,GO:0050680,GO:0051260,GO:0072014,GO:0080170,GO:1903573,GO:1904293","cytoplasm|endoplasmic reticulum|endoplasmic reticulum membrane|plasma membrane|protein glycosylation|protein targeting to membrane|monoatomic ion transport|water transport|positive regulation of cell population proliferation|cell surface|intracellular water homeostasis|water channel activity|glycerol channel activity|channel activity|glycerol transmembrane transport|urea transport|cytoplasmic vesicle membrane|intracellular oxygen homeostasis|intracellular membrane-bounded organelle|endosomal lumen acidification|perinuclear region of cytoplasm|negative regulation of epithelial cell proliferation|protein homooligomerization|proximal tubule development|hydrogen peroxide transmembrane transport|negative regulation of response to endoplasmic reticulum stress|negative regulation of ERAD pathway",null,null,"R-HSA-382551,R-HSA-432047,R-HSA-445717","Transport of small molecules|Passive transport by Aquaporins|Aquaporin-mediated transport"]
["AQP3",0.782838031489252,0.702461179728014,0.942962881791885,0.793284624665773,0.635058119505169,0.735124805645701,0.620134653261784,0.477969841348629,0.965714738496538,1.13807300140033,0.916794681127311,1.04022655079189,0.800658594790522,1.1406331692955,1.11265724909312,1.12037640535438,0.795254253780033,1.01133211299258,0.655259415226471,1.06527403742111,0.766765397830617,0.828355994588132,0.874905823223331,0.735950518981591,0.937206100655688,1.09470341562454,0.757537985168231,0.541554240570443,360,"aquaporin 3 (Gill blood group)","protein_coding","hsa04962","Vasopressin-regulated water reabsorption","GO:0002684,GO:0003091,GO:0005515,GO:0005654,GO:0005737,GO:0005886,GO:0005911,GO:0006833,GO:0015204,GO:0015250,GO:0015254,GO:0015793,GO:0016020,GO:0016323,GO:0032526,GO:0033280,GO:0042476,GO:0042802,GO:0045616,GO:0051592,GO:0051649,GO:0070295,GO:0071456,GO:0071918,GO:0090650","positive regulation of immune system process|renal water homeostasis|protein binding|nucleoplasm|cytoplasm|plasma membrane|cell-cell junction|water transport|urea transmembrane transporter activity|water channel activity|glycerol channel activity|glycerol transmembrane transport|membrane|basolateral plasma membrane|response to retinoic acid|response to vitamin D|odontogenesis|identical protein binding|regulation of keratinocyte differentiation|response to calcium ion|establishment of localization in cell|renal water absorption|cellular response to hypoxia|urea transmembrane transport|cellular response to oxygen-glucose deprivation","WP3527,WP5085","Pre-implantation embryo|Vasopressin-regulated water reabsorption","R-HSA-382551,R-HSA-432040,R-HSA-432047,R-HSA-445717","Transport of small molecules|Vasopressin regulates renal water homeostasis via Aquaporins|Passive transport by Aquaporins|Aquaporin-mediated transport"]
["AQP5",0,0,0,0,0,0,0,0,0,0,0,0.0175421683163482,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,362,"aquaporin 5","protein_coding","hsa04970","Salivary secretion","GO:0005515,GO:0005783,GO:0005886,GO:0005902,GO:0006833,GO:0009925,GO:0015250,GO:0015670,GO:0016324,GO:0030157,GO:0030659,GO:0042476,GO:0042802,GO:0046541,GO:0048593,GO:0051289,GO:0055085,GO:0070062,GO:0071476","protein binding|endoplasmic reticulum|plasma membrane|microvillus|water transport|basal plasma membrane|water channel activity|carbon dioxide transport|apical plasma membrane|pancreatic juice secretion|cytoplasmic vesicle membrane|odontogenesis|identical protein binding|saliva secretion|camera-type eye morphogenesis|protein homotetramerization|transmembrane transport|extracellular exosome|cellular hypotonic response",null,null,"R-HSA-382551,R-HSA-432047,R-HSA-445717","Transport of small molecules|Passive transport by Aquaporins|Aquaporin-mediated transport"]
["AQP5-AS1",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.103110165407587,0,0,0,0,0,0,101927318,"AQP5 and AQP2 antisense RNA 2","non_coding"]
["AQP6",0,0.0100785507311605,0,0,0,0,0,0.0103904011871217,0.0106581361741423,0,0,0,0.0604601926304494,0.0101019854703602,0,0,0,0,0,0,0,0,0,0,0.0315153510778418,0.0100681025918944,0,0,363,"aquaporin 6","protein_coding",null,null,"GO:0003097,GO:0005515,GO:0005886,GO:0006833,GO:0015112,GO:0015250,GO:0015670,GO:0015706,GO:0016324,GO:0030659,GO:0042476","renal water transport|protein binding|plasma membrane|water transport|nitrate transmembrane transporter activity|water channel activity|carbon dioxide transport|nitrate transmembrane transport|apical plasma membrane|cytoplasmic vesicle membrane|odontogenesis",null,null,"R-HSA-382551,R-HSA-432047,R-HSA-445717","Transport of small molecules|Passive transport by Aquaporins|Aquaporin-mediated transport"]
["AQP7",0,0,0.0278042844376509,0.00568063706569606,0,0,0.00552623717474916,0.029041068578376,0,0,0,0,0,0,0,0.0112320750371992,0,0,0,0,0,0,0,0.00578674670570744,0,0,0,0,364,"aquaporin 7","protein_coding","hsa04923,hsa03320","Regulation of lipolysis in adipocytes|PPAR signaling pathway","GO:0005515,GO:0005737,GO:0005811,GO:0005886,GO:0005911,GO:0005938,GO:0006833,GO:0015204,GO:0015250,GO:0015254,GO:0015793,GO:0016323,GO:0030659,GO:0071918","protein binding|cytoplasm|lipid droplet|plasma membrane|cell-cell junction|cell cortex|water transport|urea transmembrane transporter activity|water channel activity|glycerol channel activity|glycerol transmembrane transport|basolateral plasma membrane|cytoplasmic vesicle membrane|urea transmembrane transport","WP4746,WP3942","Thyroid hormones production and peripheral downstream signaling effects|PPAR signaling pathway","R-HSA-382551,R-HSA-432030,R-HSA-432047,R-HSA-445717","Transport of small molecules|Transport of glycerol from adipocytes to the liver by Aquaporins|Passive transport by Aquaporins|Aquaporin-mediated transport"]
["AQP7B",0.00737717986733528,0.0140338440394485,0,0,0,0,0,0.00723403957855441,0.014840885838543,0.00710516977133143,0,0,0,0,0,0.0139893742458384,0,0.00682584471002331,0,0,0,0.00701228136392596,0.00728290059926373,0.00720730275251083,0.00731390742036394,0.00700964778154883,0,0,100509620,"aquaporin 7B","protein_coding","hsa04923,hsa03320","Regulation of lipolysis in adipocytes|PPAR signaling pathway","GO:0005886,GO:0006833,GO:0015204,GO:0015250,GO:0015254,GO:0015793,GO:0016323,GO:0071918","plasma membrane|water transport|urea transmembrane transporter activity|water channel activity|glycerol channel activity|glycerol transmembrane transport|basolateral plasma membrane|urea transmembrane transport"]
["AQP8",0,0,0,0,0,0,0.0185198125053633,0,0,0,0,0,0.018877114635722,0,0,0,0.0190845125861108,0,0,0.0190881209454446,0,0,0,0,0,0,0.0768336801029272,0,343,"aquaporin 8","protein_coding","hsa04976","Bile secretion","GO:0005515,GO:0005739,GO:0005743,GO:0005790,GO:0005886,GO:0006833,GO:0008519,GO:0015250,GO:0015264,GO:0015265,GO:0015840,GO:0015843,GO:0016323,GO:0016324,GO:0030183,GO:0030868,GO:0031526,GO:0031966,GO:0035377,GO:0045177,GO:0045540,GO:0046691,GO:0071320,GO:0071918,GO:0072488,GO:0072489,GO:0080170,GO:0097708,GO:0140157,GO:1990748","protein binding|mitochondrion|mitochondrial inner membrane|smooth endoplasmic reticulum|plasma membrane|water transport|ammonium transmembrane transporter activity|water channel activity|methylammonium channel activity|urea channel activity|urea transport|methylammonium transport|basolateral plasma membrane|apical plasma membrane|B cell differentiation|smooth endoplasmic reticulum membrane|brush border membrane|mitochondrial membrane|transepithelial water transport|apical part of cell|regulation of cholesterol biosynthetic process|intracellular canaliculus|cellular response to cAMP|urea transmembrane transport|ammonium transmembrane transport|methylammonium transmembrane transport|hydrogen peroxide transmembrane transport|intracellular vesicle|ammonium import across plasma membrane|cellular detoxification",null,null,"R-HSA-2262752,R-HSA-3299685,R-HSA-382551,R-HSA-432047,R-HSA-445717,R-HSA-8953897,R-HSA-9711123","Cellular responses to stress|Detoxification of Reactive Oxygen Species|Transport of small molecules|Passive transport by Aquaporins|Aquaporin-mediated transport|Cellular responses to stimuli|Cellular response to chemical stress"]
["AQP9",0.00910068036301253,0,0.0427202223078154,0.00872808213571329,0,0.00854600263911052,0,0.00892409879136996,0,0,0,0.00915604058645319,0,0.00867638454982996,0.0338543273162937,0.043144136980329,0,0,0,0,0,0,0,0.00889111554951876,0,0,0,0,366,"aquaporin 9","protein_coding","hsa04613,hsa04976","Neutrophil extracellular trap formation|Bile secretion","GO:0005345,GO:0005350,GO:0005515,GO:0005886,GO:0006833,GO:0006863,GO:0015204,GO:0015250,GO:0015254,GO:0015265,GO:0015722,GO:0015793,GO:0015837,GO:0015855,GO:0016323,GO:0043231,GO:0048265,GO:0071320,GO:0071918,GO:0072531,GO:1904823","purine nucleobase transmembrane transporter activity|pyrimidine nucleobase transmembrane transporter activity|protein binding|plasma membrane|water transport|purine nucleobase transport|urea transmembrane transporter activity|water channel activity|glycerol channel activity|urea channel activity|canalicular bile acid transport|glycerol transmembrane transport|amine transport|pyrimidine nucleobase transport|basolateral plasma membrane|intracellular membrane-bounded organelle|response to pain|cellular response to cAMP|urea transmembrane transport|pyrimidine-containing compound transmembrane transport|purine nucleobase transmembrane transport","WP3527","Pre-implantation embryo","R-HSA-382551,R-HSA-432030,R-HSA-432047,R-HSA-445717","Transport of small molecules|Transport of glycerol from adipocytes to the liver by Aquaporins|Passive transport by Aquaporins|Aquaporin-mediated transport"]
["AQR",5.81986849717867,5.76542250116041,5.07362222084696,4.55524763703208,5.53597434414048,5.07742264747445,5.1940306833058,4.14800146022475,6.35124964717483,4.56646307194157,4.64116795479293,4.88881239299141,6.48557626629718,5.03170454285344,5.58223710327999,5.54741442058007,5.65216167723533,4.71960112659082,5.27241187999951,5.99896063037746,5.4003041396843,5.20360378517014,6.43872158275563,5.81482662728065,5.97323778228104,4.86003268747237,5.76224579736176,4.93266475241648,9716,"aquarius intron-binding spliceosomal factor","protein_coding","hsa03040","Spliceosome","GO:0000398,GO:0003723,GO:0003727,GO:0003729,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0016020,GO:0016887,GO:0034458,GO:0071007,GO:0071013","mRNA splicing, via spliceosome|RNA binding|single-stranded RNA binding|mRNA binding|protein binding|ATP binding|nucleus|nucleoplasm|membrane|ATP hydrolysis activity|3'-5' RNA helicase activity|U2-type catalytic step 2 spliceosome|catalytic step 2 spliceosome",null,null,"R-HSA-5696398,R-HSA-6781823,R-HSA-6781827,R-HSA-6782135,R-HSA-6782210,R-HSA-72163,R-HSA-72172,R-HSA-72203,R-HSA-73894,R-HSA-8953854","Nucleotide Excision Repair|Formation of TC-NER Pre-Incision Complex|Transcription-Coupled Nucleotide Excision Repair (TC-NER)|Dual incision in TC-NER|Gap-filling DNA repair synthesis and ligation in TC-NER|mRNA Splicing - Major Pathway|mRNA Splicing|Processing of Capped Intron-Containing Pre-mRNA|DNA Repair|Metabolism of RNA"]
["AR",3.33053086313004,3.42369229064581,3.06824417566706,2.84545509101845,3.77373768717302,3.31745331786962,3.01100311863877,2.81441958233941,3.07305481414046,2.82023123623511,2.63037677554684,2.97198690350731,3.15707500558737,3.34755400205325,2.8592693655324,3.20476812034222,3.18141825567894,3.0079665462457,1.92881345246471,3.41580926416327,2.98919389160009,3.10034960278863,2.61890408394221,2.93013529054181,3.34889279359849,2.77413874312065,2.13818583475195,2.33010929592125,367,"androgen receptor","protein_coding","hsa04114,hsa05200,hsa05207,hsa05215","Oocyte meiosis|Pathways in cancer|Chemical carcinogenesis - receptor activation|Prostate cancer","GO:0000122,GO:0000165,GO:0000785,GO:0000976,GO:0000978,GO:0000981,GO:0001091,GO:0001223,GO:0001228,GO:0001701,GO:0003073,GO:0003382,GO:0003682,GO:0003700,GO:0004879,GO:0004930,GO:0005102,GO:0005496,GO:0005497,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0006366,GO:0007165,GO:0007186,GO:0007267,GO:0007283,GO:0007338,GO:0008013,GO:0008270,GO:0008284,GO:0008285,GO:0008584,GO:0010628,GO:0016607,GO:0019102,GO:0019899,GO:0030518,GO:0030520,GO:0030521,GO:0030522,GO:0032991,GO:0033148,GO:0033327,GO:0034056,GO:0035264,GO:0042327,GO:0043410,GO:0043568,GO:0045597,GO:0045720,GO:0045726,GO:0045893,GO:0045944,GO:0045945,GO:0048009,GO:0048638,GO:0048645,GO:0048808,GO:0050673,GO:0050680,GO:0051092,GO:0051117,GO:0060090,GO:0060520,GO:0060571,GO:0060599,GO:0060736,GO:0060740,GO:0060742,GO:0060748,GO:0060749,GO:0060769,GO:0061629,GO:0070974,GO:0071383,GO:0071391,GO:0071394,GO:0072520,GO:1902895,GO:1903076,GO:2001237","negative regulation of transcription by RNA polymerase II|MAPK cascade|chromatin|transcription cis-regulatory region binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|RNA polymerase II general transcription initiation factor binding|transcription coactivator binding|DNA-binding transcription activator activity, RNA polymerase II-specific|in utero embryonic development|regulation of systemic arterial blood pressure|epithelial cell morphogenesis|chromatin binding|DNA-binding transcription factor activity|nuclear receptor activity|G protein-coupled receptor activity|signaling receptor binding|steroid binding|androgen binding|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|plasma membrane|transcription by RNA polymerase II|signal transduction|G protein-coupled receptor signaling pathway|cell-cell signaling|spermatogenesis|single fertilization|beta-catenin binding|zinc ion binding|positive regulation of cell population proliferation|negative regulation of cell population proliferation|male gonad development|positive regulation of gene expression|nuclear speck|male somatic sex determination|enzyme binding|intracellular steroid hormone receptor signaling pathway|intracellular estrogen receptor signaling pathway|androgen receptor signaling pathway|intracellular receptor signaling pathway|protein-containing complex|positive regulation of intracellular estrogen receptor signaling pathway|Leydig cell differentiation|estrogen response element binding|multicellular organism growth|positive regulation of phosphorylation|positive regulation of MAPK cascade|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of cell differentiation|negative regulation of integrin biosynthetic process|positive regulation of integrin biosynthetic process|positive regulation of DNA-templated transcription|positive regulation of transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase III|insulin-like growth factor receptor signaling pathway|regulation of developmental growth|animal organ formation|male genitalia morphogenesis|epithelial cell proliferation|negative regulation of epithelial cell proliferation|positive regulation of NF-kappaB transcription factor activity|ATPase binding|molecular adaptor activity|activation of prostate induction by androgen receptor signaling pathway|morphogenesis of an epithelial fold|lateral sprouting involved in mammary gland duct morphogenesis|prostate gland growth|prostate gland epithelium morphogenesis|epithelial cell differentiation involved in prostate gland development|tertiary branching involved in mammary gland duct morphogenesis|mammary gland alveolus development|positive regulation of epithelial cell proliferation involved in prostate gland development|RNA polymerase II-specific DNA-binding transcription factor binding|POU domain binding|cellular response to steroid hormone stimulus|cellular response to estrogen stimulus|cellular response to testosterone stimulus|seminiferous tubule development|positive regulation of miRNA transcription|regulation of protein localization to plasma membrane|negative regulation of extrinsic apoptotic signaling pathway","WP3981,WP706,WP170,WP138,WP2263,WP4673","miRNA regulation of prostate cancer signaling pathways|Sudden infant death syndrome (SIDS) susceptibility pathways|Nuclear receptors|Androgen receptor signaling pathway|Androgen receptor network in prostate cancer|Male infertility","R-HSA-162582,R-HSA-194315,R-HSA-195258,R-HSA-212436,R-HSA-212436,R-HSA-2262752,R-HSA-2990846,R-HSA-3108232,R-HSA-3371497,R-HSA-383280,R-HSA-392499,R-HSA-4090294,R-HSA-5625740,R-HSA-5625886,R-HSA-5688426,R-HSA-5689880,R-HSA-597592,R-HSA-73857,R-HSA-73857,R-HSA-74160,R-HSA-74160,R-HSA-8878166,R-HSA-8878166,R-HSA-8940973,R-HSA-8940973,R-HSA-8941326,R-HSA-8941326,R-HSA-8953897,R-HSA-9716542","Signal Transduction|Signaling by Rho GTPases|RHO GTPase Effectors|Generic Transcription Pathway|Generic Transcription Pathway|Cellular responses to stress|SUMOylation|SUMO E3 ligases SUMOylate target proteins|HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand|Nuclear Receptor transcription pathway|Metabolism of proteins|SUMOylation of intracellular receptors|RHO GTPases activate PKNs|Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3|Deubiquitination|Ub-specific processing proteases|Post-translational protein modification|RNA Polymerase II Transcription|RNA Polymerase II Transcription|Gene expression (Transcription)|Gene expression (Transcription)|Transcriptional regulation by RUNX2|Transcriptional regulation by RUNX2|RUNX2 regulates osteoblast differentiation|RUNX2 regulates osteoblast differentiation|RUNX2 regulates bone development|RUNX2 regulates bone development|Cellular responses to stimuli|Signaling by Rho GTPases, Miro GTPases and RHOBTB3","Androgen_rcpt"]
["ARAF",17.4517329710239,20.4641961077073,19.921642409429,20.1104227314268,16.3972104210563,19.1026027769402,17.2341981105687,17.8239674101251,18.652332782464,25.8329960698213,22.6995369047831,20.6732939343966,15.3963927990162,19.2148617976145,16.8708915168092,17.4293948136254,18.5168940683439,20.7764163861875,20.8108860177027,20.5600482850962,19.7155351341869,21.0716680309019,16.5572247715524,17.9941655386103,18.615234782202,22.0671950593817,16.87040073086,21.9596676234988,369,"A-Raf proto-oncogene%2C serine/threonine kinase","protein_coding","hsa04010,hsa04012,hsa04068,hsa04810,hsa04650,hsa04910,hsa04914,hsa04928,hsa04270,hsa04726,hsa04720,hsa04730,hsa05200,hsa05205,hsa05208,hsa05210,hsa05212,hsa05225,hsa05226,hsa05214,hsa05221,hsa05220,hsa05218,hsa05211,hsa05219,hsa05215,hsa05213,hsa05224,hsa05223,hsa05161,hsa05160,hsa05010,hsa05022,hsa05034,hsa01521,hsa01522","MAPK signaling pathway|ErbB signaling pathway|FoxO signaling pathway|Regulation of actin cytoskeleton|Natural killer cell mediated cytotoxicity|Insulin signaling pathway|Progesterone-mediated oocyte maturation|Parathyroid hormone synthesis, secretion and action|Vascular smooth muscle contraction|Serotonergic synapse|Long-term potentiation|Long-term depression|Pathways in cancer|Proteoglycans in cancer|Chemical carcinogenesis - reactive oxygen species|Colorectal cancer|Pancreatic cancer|Hepatocellular carcinoma|Gastric cancer|Glioma|Acute myeloid leukemia|Chronic myeloid leukemia|Melanoma|Renal cell carcinoma|Bladder cancer|Prostate cancer|Endometrial cancer|Breast cancer|Non-small cell lung cancer|Hepatitis B|Hepatitis C|Alzheimer disease|Pathways of neurodegeneration - multiple diseases|Alcoholism|EGFR tyrosine kinase inhibitor resistance|Endocrine resistance","GO:0000165,GO:0004672,GO:0004674,GO:0004709,GO:0005515,GO:0005524,GO:0005575,GO:0005739,GO:0005829,GO:0016310,GO:0032006,GO:0032434,GO:0033138,GO:0036211,GO:0043066,GO:0046872,GO:0106310","MAPK cascade|protein kinase activity|protein serine/threonine kinase activity|MAP kinase kinase kinase activity|protein binding|ATP binding|cellular_component|mitochondrion|cytosol|phosphorylation|regulation of TOR signaling|regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of peptidyl-serine phosphorylation|protein modification process|negative regulation of apoptotic process|metal ion binding|protein serine kinase activity","WP4205,WP185,WP4216,WP5124,WP4666,WP4262,WP4549,WP4806,WP2828,WP4685,WP673,WP2636,WP2261,WP2059,WP4301,WP382,WP422,WP4263,WP4255,WP4155,WP3931","MET in type 1 papillary renal cell carcinoma|Integrin-mediated cell adhesion|Chromosomal and microsatellite instability in colorectal cancer |Alzheimer's disease|Hepatitis B infection|Breast cancer pathway|Fragile X syndrome|EGFR tyrosine kinase inhibitor resistance|Bladder cancer|Melanoma|ErbB signaling pathway|Common pathways underlying drug addiction|Glioblastoma signaling pathways|Alzheimer's disease and miRNA effects|Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells|MAPK signaling pathway|MAPK cascade|Pancreatic adenocarcinoma pathway|Non-small cell lung cancer|Endometrial cancer|Embryonic stem cell pluripotency pathways","R-HSA-162582,R-HSA-1643685,R-HSA-5663202,R-HSA-5673000,R-HSA-5673001,R-HSA-5674135,R-HSA-5675221,R-HSA-5683057,R-HSA-5684996,R-HSA-6802946,R-HSA-6802948,R-HSA-6802949,R-HSA-6802952,R-HSA-6802955,R-HSA-6802957,R-HSA-9649948,R-HSA-9656223,R-HSA-9660537,R-HSA-9726840,R-HSA-9726842","Signal Transduction|Disease|Diseases of signal transduction by growth factor receptors and second messengers|RAF activation|RAF/MAP kinase cascade|MAP2K and MAPK activation|Negative regulation of MAPK pathway|MAPK family signaling cascades|MAPK1/MAPK3 signaling|Signaling by moderate kinase activity BRAF mutants|Signaling by high-kinase activity BRAF mutants|Signaling by RAS mutants|Signaling by BRAF and RAF1 fusions|Paradoxical activation of RAF signaling by kinase inactive BRAF|Oncogenic MAPK signaling|Signaling downstream of RAS mutants|Signaling by RAF1 mutants|Signaling by MRAS-complex mutants|SHOC2 M1731 mutant abolishes MRAS complex function|Gain-of-function MRAS complexes activate RAF signaling"]
["ARAP1",17.6859885685453,22.4887715860703,21.9328329640629,22.3411699868241,20.3092694853826,21.9647552866163,20.6160637532477,21.6024665417876,16.1955956427009,22.4497722245307,20.4305503692064,18.7156701026985,16.3652583034344,18.2403753771344,18.3568000667352,18.0906093905341,14.3742372346293,17.3933353664484,16.8178318347095,16.0111172011282,14.3590914379872,16.9291572061667,13.6569436962243,13.9535627588033,14.4202459668121,15.9158676740166,12.439702076427,16.2409346185158,116985,"ArfGAP with RhoGAP domain%2C ankyrin repeat and PH domain 1","protein_coding","hsa04144","Endocytosis","GO:0001921,GO:0005096,GO:0005515,GO:0005547,GO:0005654,GO:0005737,GO:0005794,GO:0005802,GO:0005829,GO:0005886,GO:0007015,GO:0007165,GO:0008360,GO:0031702,GO:0032580,GO:0043231,GO:0043547,GO:0046872,GO:0051056,GO:0051491,GO:0051497","positive regulation of receptor recycling|GTPase activator activity|protein binding|phosphatidylinositol-3,4,5-trisphosphate binding|nucleoplasm|cytoplasm|Golgi apparatus|trans-Golgi network|cytosol|plasma membrane|actin filament organization|signal transduction|regulation of cell shape|type 1 angiotensin receptor binding|Golgi cisterna membrane|intracellular membrane-bounded organelle|positive regulation of GTPase activity|metal ion binding|regulation of small GTPase mediated signal transduction|positive regulation of filopodium assembly|negative regulation of stress fiber assembly",null,null,"R-HSA-162582,R-HSA-194315,R-HSA-8848021,R-HSA-8849469,R-HSA-8980692,R-HSA-9006927,R-HSA-9012999,R-HSA-9013148,R-HSA-9013149,R-HSA-9716542","Signal Transduction|Signaling by Rho GTPases|Signaling by PTK6|PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1|RHOA GTPase cycle|Signaling by Non-Receptor Tyrosine Kinases|RHO GTPase cycle|CDC42 GTPase cycle|RAC1 GTPase cycle|Signaling by Rho GTPases, Miro GTPases and RHOBTB3"]
["ARAP1-AS2",0.67981683159056,0.337366224474638,0.110997630241885,0.35433908012586,0.259938935727482,0.541237463193404,0.358496458300093,0.43475626019799,0.267575313424521,0.384310218914483,0.152882884965035,0.565004004522382,0.309195546522386,0.422688339417703,0.233648683893181,0.182160980105761,0.241548825418287,0.054696571426371,0.218539552775641,0.369497464003156,0.111590657977741,0.168571553314378,0.277205404059475,0.447587725870566,0.468859959894909,0.182550596995138,0.286020113979646,0.111148952883609,100506020,"ARAP1 antisense RNA 2","non_coding"]
["ARAP3",5.59622961774147,7.54274274955365,7.11518190286702,7.14384018827228,5.83045229155252,7.06258927062512,6.42440460586355,6.00196461061908,5.74037092724805,7.9203059976181,6.86036330172918,6.69532771085573,5.64228936552265,6.32623044974408,5.96969271507899,6.24136855946036,5.05196550453354,6.01502160061486,4.71408774677053,5.49713350120841,5.28201093038375,5.07243298805749,4.45587151459258,4.4707328684485,5.11887611694619,5.22598146588538,4.19539735627353,4.94444192331437,64411,"ArfGAP with RhoGAP domain%2C ankyrin repeat and PH domain 3","protein_coding","hsa04015,hsa04024,hsa04144","Rap1 signaling pathway|cAMP signaling pathway|Endocytosis","GO:0001726,GO:0005096,GO:0005515,GO:0005547,GO:0005737,GO:0005856,GO:0005886,GO:0007010,GO:0007165,GO:0016192,GO:0030027,GO:0043325,GO:0046872","ruffle|GTPase activator activity|protein binding|phosphatidylinositol-3,4,5-trisphosphate binding|cytoplasm|cytoskeleton|plasma membrane|cytoskeleton organization|signal transduction|vesicle-mediated transport|lamellipodium|phosphatidylinositol-3,4-bisphosphate binding|metal ion binding",null,null,"R-HSA-162582,R-HSA-194315,R-HSA-8980692,R-HSA-9012999,R-HSA-9013148,R-HSA-9013149,R-HSA-9013423,R-HSA-9716542","Signal Transduction|Signaling by Rho GTPases|RHOA GTPase cycle|RHO GTPase cycle|CDC42 GTPase cycle|RAC1 GTPase cycle|RAC3 GTPase cycle|Signaling by Rho GTPases, Miro GTPases and RHOBTB3"]
["ARC",0.849806107416138,0.738774850883446,1.37260798346575,0.981521654247482,0.553596504021647,0.420457535944143,0.349541057855465,0.58242601366185,0.0643390132166533,0.0264023291638424,0.060154350546489,0,0.00868987175434257,0.00871167831749029,0.0169960199170952,0.0259917831326917,0,0.0253643761733137,0.0422262864685137,0,0.0344985356188813,0.0260571621394428,0.0721673729890431,0.00892728279921172,0.00905932803864741,0.00868245864195914,0.0176847690813178,0.0171809906830257,23237,"activity regulated cytoskeleton associated protein","protein_coding","hsa05031","Amphetamine addiction","GO:0001669,GO:0003729,GO:0005515,GO:0005737,GO:0005829,GO:0005886,GO:0005938,GO:0006897,GO:0007010,GO:0007492,GO:0007612,GO:0007616,GO:0009952,GO:0015629,GO:0016477,GO:0022604,GO:0031901,GO:0043025,GO:0043197,GO:0045121,GO:0048168,GO:0050804,GO:0051028,GO:0051260,GO:0060291,GO:0060997,GO:0061001,GO:0071598,GO:0098839,GO:0098845,GO:0098978,GO:0099149,GO:0110077,GO:1900271,GO:1900452,GO:1903561,GO:2000969","acrosomal vesicle|mRNA binding|protein binding|cytoplasm|cytosol|plasma membrane|cell cortex|endocytosis|cytoskeleton organization|endoderm development|learning|long-term memory|anterior/posterior pattern specification|actin cytoskeleton|cell migration|regulation of cell morphogenesis|early endosome membrane|neuronal cell body|dendritic spine|membrane raft|regulation of neuronal synaptic plasticity|modulation of chemical synaptic transmission|mRNA transport|protein homooligomerization|long-term synaptic potentiation|dendritic spine morphogenesis|regulation of dendritic spine morphogenesis|neuronal ribonucleoprotein granule|postsynaptic density membrane|postsynaptic endosome|glutamatergic synapse|regulation of postsynaptic neurotransmitter receptor internalization|vesicle-mediated intercellular transport|regulation of long-term synaptic potentiation|regulation of long-term synaptic depression|extracellular vesicle|positive regulation of AMPA receptor activity","WP5083,WP3944,WP4549,WP5323,WP4875,WP3676,WP5093,WP4539,WP3947,WP5094","Neuroinflammation and glutamatergic signaling|Serotonin and anxiety-related events|Fragile X syndrome|Fatty Acids and Lipoproteins Transport in Hepatocytes|Disruption of postsynaptic signaling by CNV|BDNF-TrkB signaling|Opioid receptor pathways|Synaptic signaling pathways associated with autism spectrum disorder|Serotonin and anxiety|Orexin receptor pathway","R-HSA-162582,R-HSA-162582,R-HSA-166520,R-HSA-166520,R-HSA-187037,R-HSA-187037,R-HSA-198725,R-HSA-198725,R-HSA-9006934,R-HSA-9006934,R-HSA-9031628,R-HSA-9031628","Signal Transduction|Signal Transduction|Signaling by NTRKs|Signaling by NTRKs|Signaling by NTRK1 (TRKA)|Signaling by NTRK1 (TRKA)|Nuclear Events (kinase and transcription factor activation)|Nuclear Events (kinase and transcription factor activation)|Signaling by Receptor Tyrosine Kinases|Signaling by Receptor Tyrosine Kinases|NGF-stimulated transcription|NGF-stimulated transcription"]
["ARCN1",66.4722642224699,62.6758584535589,62.2928562448872,56.5827602540726,67.3992835900688,59.5528076604159,58.7103106927575,59.8061431248472,73.17544876211,61.1380513327137,59.0147012940948,67.1744217006396,68.3581919392796,61.1989422987777,67.3056385938267,66.744460125317,63.6956157148518,61.8654669012867,57.2507090150297,70.9077628204489,63.1082349184167,62.909372375603,63.7233445937769,62.1088909995071,64.3881509885328,58.3792961298197,59.2202540281516,61.1255441860195,372,"archain 1","protein_coding",null,null,"GO:0000139,GO:0003723,GO:0005515,GO:0005789,GO:0005829,GO:0006886,GO:0006888,GO:0006890,GO:0008344,GO:0016020,GO:0021691,GO:0030126,GO:0030133,GO:0043473,GO:0051645","Golgi membrane|RNA binding|protein binding|endoplasmic reticulum membrane|cytosol|intracellular protein transport|endoplasmic reticulum to Golgi vesicle-mediated transport|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|adult locomotory behavior|membrane|cerebellar Purkinje cell layer maturation|COPI vesicle coat|transport vesicle|pigmentation|Golgi localization","WP3596","miR-517 relationship with ARCN1 and USP1","R-HSA-199977,R-HSA-199991,R-HSA-392499,R-HSA-446203,R-HSA-5653656,R-HSA-597592,R-HSA-6807878,R-HSA-6811434,R-HSA-6811442,R-HSA-8856688,R-HSA-948021","ER to Golgi Anterograde Transport|Membrane Trafficking|Metabolism of proteins|Asparagine N-linked glycosylation|Vesicle-mediated transport|Post-translational protein modification|COPI-mediated anterograde transport|COPI-dependent Golgi-to-ER retrograde traffic|Intra-Golgi and retrograde Golgi-to-ER traffic|Golgi-to-ER retrograde transport|Transport to the Golgi and subsequent modification"]
["AREG",1.48543163370869,0.519445564426104,0.881864478842337,0.81705882670448,0.640368204709518,0.615395295390082,0.570662358755216,0.685463354814595,0.63720798572409,0.631173995407903,1.0066347964222,1.07689580116421,0.851734188563803,0.916349955924019,1.07671301217092,0.579935517763463,0.420044863726719,0.485088555664671,0.38359535762726,0.378111854449309,0.597923363491755,0.373753460184876,0.603831544661159,0.44817274668652,0.303201173416643,0.269831676595731,0.887821267899221,0.492874449091663,374,"amphiregulin","protein_coding","hsa04010,hsa04012,hsa04390,hsa04151,hsa05210","MAPK signaling pathway|ErbB signaling pathway|Hippo signaling pathway|PI3K-Akt signaling pathway|Colorectal cancer","GO:0005125,GO:0005154,GO:0005515,GO:0005576,GO:0005615,GO:0005634,GO:0005789,GO:0007173,GO:0007186,GO:0007267,GO:0008083,GO:0008284,GO:0009986,GO:0010838,GO:0012507,GO:0014009,GO:0030297,GO:0030669,GO:0031175,GO:0032355,GO:0033116,GO:0038134,GO:0042542,GO:0043434,GO:0045668,GO:0048018,GO:0050731,GO:0051384,GO:0051591,GO:0060598,GO:0060744,GO:0060749,GO:0060750","cytokine activity|epidermal growth factor receptor binding|protein binding|extracellular region|extracellular space|nucleus|endoplasmic reticulum membrane|epidermal growth factor receptor signaling pathway|G protein-coupled receptor signaling pathway|cell-cell signaling|growth factor activity|positive regulation of cell population proliferation|cell surface|positive regulation of keratinocyte proliferation|ER to Golgi transport vesicle membrane|glial cell proliferation|transmembrane receptor protein tyrosine kinase activator activity|clathrin-coated endocytic vesicle membrane|neuron projection development|response to estradiol|endoplasmic reticulum-Golgi intermediate compartment membrane|ERBB2-EGFR signaling pathway|response to hydrogen peroxide|response to peptide hormone|negative regulation of osteoblast differentiation|receptor ligand activity|positive regulation of peptidyl-tyrosine phosphorylation|response to glucocorticoid|response to cAMP|dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis|mammary gland branching involved in thelarche|mammary gland alveolus development|epithelial cell proliferation involved in mammary gland duct elongation","WP3893,WP5095,WP673,WP2643,WP2814,WP2035,WP5088,WP5390,WP5087","Development and heterogeneity of the ILC family|Overview of proinflammatory and profibrotic mediators|ErbB signaling pathway|Nanoparticle-mediated activation of receptor signaling|Mammary gland development pathway - Puberty (Stage 2 of 4)|Follicle stimulating hormone (FSH) signaling pathway|Prostaglandin signaling|Pancreatic cancer subtypes|Pleural mesothelioma","R-HSA-1257604,R-HSA-162582,R-HSA-1643685,R-HSA-1643713,R-HSA-177929,R-HSA-179812,R-HSA-180292,R-HSA-180336,R-HSA-182971,R-HSA-199418,R-HSA-199977,R-HSA-199991,R-HSA-204005,R-HSA-212718,R-HSA-2219528,R-HSA-2219530,R-HSA-392499,R-HSA-446203,R-HSA-5638302,R-HSA-5638303,R-HSA-5653656,R-HSA-5663202,R-HSA-5673001,R-HSA-5683057,R-HSA-5684996,R-HSA-5694530,R-HSA-597592,R-HSA-6811558,R-HSA-8856825,R-HSA-8856828,R-HSA-8939211,R-HSA-9006925,R-HSA-9006931,R-HSA-9006934,R-HSA-9009391,R-HSA-948021,R-HSA-9634638","PIP3 activates AKT signaling|Signal Transduction|Disease|Signaling by EGFR in Cancer|Signaling by EGFR|GRB2 events in EGFR signaling|GAB1 signalosome|SHC1 events in EGFR signaling|EGFR downregulation|Negative regulation of the PI3K/AKT network|ER to Golgi Anterograde Transport|Membrane Trafficking|COPII-mediated vesicle transport|EGFR interacts with phospholipase C-gamma|PI3K/AKT Signaling in Cancer|Constitutive Signaling by Aberrant PI3K in Cancer|Metabolism of proteins|Asparagine N-linked glycosylation|Signaling by Overexpressed Wild-Type EGFR in Cancer|Inhibition of Signaling by Overexpressed EGFR|Vesicle-mediated transport|Diseases of signal transduction by growth factor receptors and second messengers|RAF/MAP kinase cascade|MAPK family signaling cascades|MAPK1/MAPK3 signaling|Cargo concentration in the ER|Post-translational protein modification|PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling|Cargo recognition for clathrin-mediated endocytosis|Clathrin-mediated endocytosis|ESR-mediated signaling|Intracellular signaling by second messengers|Signaling by Nuclear Receptors|Signaling by Receptor Tyrosine Kinases|Extra-nuclear estrogen signaling|Transport to the Golgi and subsequent modification|Estrogen-dependent nuclear events downstream of ESR-membrane signaling"]
["AREL1",11.4034313549235,11.6229596514207,9.93504816439013,9.69704713304437,10.9815298326514,10.5395872706155,9.39268275992994,9.59084221127183,10.1800799609731,10.865976600541,9.42200275361102,10.3338295506299,11.0432481622192,10.6772232587156,10.1126012161729,11.0885937816118,11.2907044841772,11.7425296903299,8.94964374003808,12.4048358304958,11.8408388588436,10.6685010453757,10.1256918466252,10.8892575499469,11.7728809107858,10.9276441665962,9.71841494130296,10.6017829990215,9870,"apoptosis resistant E3 ubiquitin protein ligase 1","protein_coding",null,null,"GO:0000209,GO:0004842,GO:0005515,GO:0005737,GO:0005829,GO:0006511,GO:0006915,GO:0016567,GO:0043066,GO:0050727,GO:0061630,GO:0070979,GO:1990390","protein polyubiquitination|ubiquitin-protein transferase activity|protein binding|cytoplasm|cytosol|ubiquitin-dependent protein catabolic process|apoptotic process|protein ubiquitination|negative regulation of apoptotic process|regulation of inflammatory response|ubiquitin protein ligase activity|protein K11-linked ubiquitination|protein K33-linked ubiquitination",null,null,"R-HSA-1280218,R-HSA-168256,R-HSA-983168,R-HSA-983169","Adaptive Immune System|Immune System|Antigen processing: Ubiquitination & Proteasome degradation|Class I MHC mediated antigen processing & presentation"]
["ARF1",187.346866876044,195.428545122516,214.058013781174,209.134114449857,175.103539265138,196.17226548049,216.49458082334,206.011161383188,196.996803297949,242.333506790222,224.610834960361,210.493689983695,183.354595301472,201.654728094717,203.438925241139,187.592476837443,213.199755585161,232.329936133635,254.968444360518,224.545606625492,209.122832071277,228.279568207009,220.616004075942,215.6947090331,209.678777121082,236.004652150762,221.734123822875,245.108065767773,375,"ADP ribosylation factor 1","protein_coding","hsa04072,hsa04144,hsa05110,hsa05130,hsa05132,hsa05131,hsa05134","Phospholipase D signaling pathway|Endocytosis|Vibrio cholerae infection|Pathogenic Escherichia coli infection|Salmonella infection|Shigellosis|Legionellosis","GO:0000139,GO:0000287,GO:0002090,GO:0003723,GO:0003924,GO:0005515,GO:0005525,GO:0005737,GO:0005829,GO:0005886,GO:0005925,GO:0006878,GO:0006886,GO:0014069,GO:0016192,GO:0019904,GO:0030017,GO:0031252,GO:0032991,GO:0034315,GO:0043005,GO:0060292,GO:0070062,GO:0097061,GO:0098586,GO:1990386","Golgi membrane|magnesium ion binding|regulation of receptor internalization|RNA binding|GTPase activity|protein binding|GTP binding|cytoplasm|cytosol|plasma membrane|focal adhesion|intracellular copper ion homeostasis|intracellular protein transport|postsynaptic density|vesicle-mediated transport|protein domain specific binding|sarcomere|cell leading edge|protein-containing complex|regulation of Arp2/3 complex-mediated actin nucleation|neuron projection|long-term synaptic depression|extracellular exosome|dendritic spine organization|cellular response to virus|mitotic cleavage furrow ingression","WP5224,WP4564,WP481,WP4565","2q37 copy number variation syndrome|Neural crest cell migration during development|Insulin signaling|Neural crest cell migration in cancer","R-HSA-1280215,R-HSA-1280218,R-HSA-1430728,R-HSA-1483255,R-HSA-1483257,R-HSA-162906,R-HSA-162909,R-HSA-1643685,R-HSA-164938,R-HSA-164952,R-HSA-1660499,R-HSA-1660514,R-HSA-167590,R-HSA-168256,R-HSA-199977,R-HSA-199991,R-HSA-199992,R-HSA-2132295,R-HSA-392499,R-HSA-432720,R-HSA-432722,R-HSA-446203,R-HSA-447115,R-HSA-449147,R-HSA-556833,R-HSA-5653656,R-HSA-5663205,R-HSA-597592,R-HSA-6807878,R-HSA-6811434,R-HSA-6811438,R-HSA-6811442,R-HSA-8856688,R-HSA-8950505,R-HSA-9020591,R-HSA-948021,R-HSA-9824446","Cytokine Signaling in Immune system|Adaptive Immune System|Metabolism|PI Metabolism|Phospholipid metabolism|HIV Infection|Host Interactions of HIV factors|Disease|Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters|The role of Nef in HIV-1 replication and disease pathogenesis|Synthesis of PIPs at the plasma membrane|Synthesis of PIPs at the Golgi membrane|Nef Mediated CD4 Down-regulation|Immune System|ER to Golgi Anterograde Transport|Membrane Trafficking|trans-Golgi Network Vesicle Budding|MHC class II antigen presentation|Metabolism of proteins|Lysosome Vesicle Biogenesis|Golgi Associated Vesicle Biogenesis|Asparagine N-linked glycosylation|Interleukin-12 family signaling|Signaling by Interleukins|Metabolism of lipids|Vesicle-mediated transport|Infectious disease|Post-translational protein modification|COPI-mediated anterograde transport|COPI-dependent Golgi-to-ER retrograde traffic|Intra-Golgi traffic|Intra-Golgi and retrograde Golgi-to-ER traffic|Golgi-to-ER retrograde transport|Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation|Interleukin-12 signaling|Transport to the Golgi and subsequent modification|Viral Infection Pathways"]
["ARF3",36.3468352254265,33.9758039553242,34.7828274048179,32.5540956434574,33.8959281726399,33.7996839263082,36.4214238930638,35.0917683637803,34.6310397843422,33.0870580145689,33.3047242287028,33.5530013131362,34.3459548402823,34.1760922017872,34.5122291520516,34.0825831662268,40.5218476808933,38.295286774098,38.1606501504834,39.2699001345919,38.8866818118301,38.1991802637976,38.8360846312333,40.4584113163261,40.047819762665,37.8132380327672,39.690652754411,37.6386374418219,377,"ADP ribosylation factor 3","protein_coding","hsa04144","Endocytosis","GO:0000139,GO:0003924,GO:0005515,GO:0005525,GO:0005737,GO:0005886,GO:0006886,GO:0006890,GO:0016192,GO:0048471,GO:0070062","Golgi membrane|GTPase activity|protein binding|GTP binding|cytoplasm|plasma membrane|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|vesicle-mediated transport|perinuclear region of cytoplasm|extracellular exosome",null,null,"R-HSA-1430728,R-HSA-1483255,R-HSA-1483257,R-HSA-1660514,R-HSA-199977,R-HSA-199991,R-HSA-392499,R-HSA-446203,R-HSA-556833,R-HSA-5653656,R-HSA-597592,R-HSA-6807878,R-HSA-6811434,R-HSA-6811442,R-HSA-8856688,R-HSA-948021","Metabolism|PI Metabolism|Phospholipid metabolism|Synthesis of PIPs at the Golgi membrane|ER to Golgi Anterograde Transport|Membrane Trafficking|Metabolism of proteins|Asparagine N-linked glycosylation|Metabolism of lipids|Vesicle-mediated transport|Post-translational protein modification|COPI-mediated anterograde transport|COPI-dependent Golgi-to-ER retrograde traffic|Intra-Golgi and retrograde Golgi-to-ER traffic|Golgi-to-ER retrograde transport|Transport to the Golgi and subsequent modification"]
["ARF4",160.588780987901,140.826301130699,130.073365839169,140.828524005222,157.712791734083,139.82562565606,131.375163641664,143.991273377574,156.009149408087,129.599979432452,135.283483765943,156.077046061295,162.002404271417,149.253265450007,145.356969462017,148.194963507579,166.153114734784,153.494207014233,146.171740870793,160.548678315217,161.39197448095,158.746239921197,157.702779644783,163.276702211585,166.729950738343,156.921295597227,157.065902591109,155.640290880734,378,"ADP ribosylation factor 4","protein_coding","hsa04144","Endocytosis","GO:0000139,GO:0003924,GO:0005085,GO:0005154,GO:0005515,GO:0005525,GO:0005737,GO:0005829,GO:0005886,GO:0006886,GO:0006888,GO:0006890,GO:0007612,GO:0016020,GO:0016192,GO:0016477,GO:0031584,GO:0032587,GO:0043066,GO:0043197,GO:0045176,GO:0045197,GO:0045944,GO:0060271,GO:0060996,GO:0061512,GO:0070062,GO:0098978,GO:0099175,GO:0106274,GO:1902017,GO:2000377","Golgi membrane|GTPase activity|guanyl-nucleotide exchange factor activity|epidermal growth factor receptor binding|protein binding|GTP binding|cytoplasm|cytosol|plasma membrane|intracellular protein transport|endoplasmic reticulum to Golgi vesicle-mediated transport|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|learning|membrane|vesicle-mediated transport|cell migration|activation of phospholipase D activity|ruffle membrane|negative regulation of apoptotic process|dendritic spine|apical protein localization|establishment or maintenance of epithelial cell apical/basal polarity|positive regulation of transcription by RNA polymerase II|cilium assembly|dendritic spine development|protein localization to cilium|extracellular exosome|glutamatergic synapse|regulation of postsynapse organization|NAD+-protein-arginine ADP-ribosyltransferase activity|regulation of cilium assembly|regulation of reactive oxygen species metabolic process","WP3888","VEGFA-VEGFR2 signaling","R-HSA-1852241,R-HSA-1852241,R-HSA-199977,R-HSA-199991,R-HSA-392499,R-HSA-446203,R-HSA-5617833,R-HSA-5617833,R-HSA-5620916,R-HSA-5620916,R-HSA-5620920,R-HSA-5620920,R-HSA-5653656,R-HSA-597592,R-HSA-6807878,R-HSA-6811434,R-HSA-6811442,R-HSA-8856688,R-HSA-948021","Organelle biogenesis and maintenance|Organelle biogenesis and maintenance|ER to Golgi Anterograde Transport|Membrane Trafficking|Metabolism of proteins|Asparagine N-linked glycosylation|Cilium Assembly|Cilium Assembly|VxPx cargo-targeting to cilium|VxPx cargo-targeting to cilium|Cargo trafficking to the periciliary membrane|Cargo trafficking to the periciliary membrane|Vesicle-mediated transport|Post-translational protein modification|COPI-mediated anterograde transport|COPI-dependent Golgi-to-ER retrograde traffic|Intra-Golgi and retrograde Golgi-to-ER traffic|Golgi-to-ER retrograde transport|Transport to the Golgi and subsequent modification"]
["ARF4-AS1",0.09838034757388,0.233940082664895,1.01599290746952,0.566114874875535,0.528732239095316,0.69288119937168,0.963773746401373,0.964714621169264,0.593743761175581,0.331635095640721,0.971470807183262,0.1979576074239,0.608132448501893,0.234484042304711,0.594705623923908,0.466397568378593,0.898574076180352,1.27439018972975,2.00035473854492,0.993348600587936,1.67141627861551,0.794870244095534,1.50540744978284,0.624746889324397,0.48768280500018,0.607613665910826,2.85602566367997,1.20235582608401,106144532,"ARF4 antisense RNA 1","non_coding"]
["ARF5",64.9352239097038,69.1679217434515,83.8922670708408,82.7182333355767,58.4237945928885,74.2473231261592,88.0977790280569,86.9836059938454,75.0109709390862,100.075572664924,103.540176257292,86.5375900880095,77.5015306462877,93.5340485401704,89.9039223129119,81.9756997413335,94.0989632175328,95.4404290858615,114.645595270342,93.112038934291,97.7521188227109,97.8982562763818,102.733612071902,96.3082534771937,83.671058366246,107.913201566815,104.517070952609,110.821968173382,381,"ADP ribosylation factor 5","protein_coding","hsa04144","Endocytosis","GO:0003924,GO:0005515,GO:0005525,GO:0005737,GO:0005794,GO:0005886,GO:0006886,GO:0006890,GO:0016192,GO:0048471,GO:0070062","GTPase activity|protein binding|GTP binding|cytoplasm|Golgi apparatus|plasma membrane|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|vesicle-mediated transport|perinuclear region of cytoplasm|extracellular exosome","WP5224","2q37 copy number variation syndrome","R-HSA-199977,R-HSA-199991,R-HSA-392499,R-HSA-446203,R-HSA-5653656,R-HSA-597592,R-HSA-6807878,R-HSA-6811434,R-HSA-6811442,R-HSA-8856688,R-HSA-948021","ER to Golgi Anterograde Transport|Membrane Trafficking|Metabolism of proteins|Asparagine N-linked glycosylation|Vesicle-mediated transport|Post-translational protein modification|COPI-mediated anterograde transport|COPI-dependent Golgi-to-ER retrograde traffic|Intra-Golgi and retrograde Golgi-to-ER traffic|Golgi-to-ER retrograde transport|Transport to the Golgi and subsequent modification"]
["ARF6",50.0307354766112,45.6091275569238,47.9306959232787,46.4479114810354,47.3448864474788,44.7277135399509,46.8988945270658,45.1649261639407,46.4126816687514,35.4628136240381,41.1173004569517,44.9740271450115,43.4573198155135,39.8324910776252,43.6299892963389,41.3752295909296,45.5065006703355,45.5064182072016,40.6459881295037,48.5654997292423,45.612962224896,46.1806881829258,46.4795129725819,45.8475294973607,44.7531974054735,42.9443366969252,42.4226804534028,40.9918485578782,382,"ADP ribosylation factor 6","protein_coding","hsa04014,hsa04072,hsa04144,hsa04666,hsa05130,hsa05132,hsa05131,hsa05135","Ras signaling pathway|Phospholipase D signaling pathway|Endocytosis|Fc gamma R-mediated phagocytosis|Pathogenic Escherichia coli infection|Salmonella infection|Shigellosis|Yersinia infection","GO:0001726,GO:0001889,GO:0003924,GO:0003925,GO:0005515,GO:0005525,GO:0005737,GO:0005768,GO:0005794,GO:0005829,GO:0005886,GO:0005925,GO:0005938,GO:0006886,GO:0007049,GO:0007155,GO:0007399,GO:0016020,GO:0016192,GO:0019003,GO:0030139,GO:0030154,GO:0030838,GO:0030866,GO:0031527,GO:0031901,GO:0031996,GO:0032154,GO:0032456,GO:0034394,GO:0035020,GO:0036010,GO:0048261,GO:0048488,GO:0050714,GO:0051301,GO:0051489,GO:0051549,GO:0055038,GO:0060998,GO:0070062,GO:0090162,GO:0090543,GO:0097178,GO:0097284,GO:0098793,GO:0098794,GO:0098978,GO:0099562,GO:0120183,GO:1902217,GO:1903078,GO:1905606,GO:1990090,GO:2000009,GO:2000171","ruffle|liver development|GTPase activity|G protein activity|protein binding|GTP binding|cytoplasm|endosome|Golgi apparatus|cytosol|plasma membrane|focal adhesion|cell cortex|intracellular protein transport|cell cycle|cell adhesion|nervous system development|membrane|vesicle-mediated transport|GDP binding|endocytic vesicle|cell differentiation|positive regulation of actin filament polymerization|cortical actin cytoskeleton organization|filopodium membrane|early endosome membrane|thioesterase binding|cleavage furrow|endocytic recycling|protein localization to cell surface|regulation of Rac protein signal transduction|protein localization to endosome|negative regulation of receptor-mediated endocytosis|synaptic vesicle endocytosis|positive regulation of protein secretion|cell division|regulation of filopodium assembly|positive regulation of keratinocyte migration|recycling endosome membrane|regulation of dendritic spine development|extracellular exosome|establishment of epithelial cell polarity|Flemming body|ruffle assembly|hepatocyte apoptotic process|presynapse|postsynapse|glutamatergic synapse|maintenance of postsynaptic density structure|positive regulation of focal adhesion disassembly|erythrocyte apoptotic process|positive regulation of protein localization to plasma membrane|regulation of presynapse assembly|cellular response to nerve growth factor stimulus|negative regulation of protein localization to cell surface|negative regulation of dendrite development","WP4223,WP5222,WP4754,WP5366,WP481,WP437,WP5345,WP3888","Ras signaling|2q13 copy number variation syndrome|IL-18 signaling pathway|NF1 copy number variation syndrome |Insulin signaling|EGF/EGFR signaling pathway|1p36 copy number variation syndrome|VEGFA-VEGFR2 signaling","R-HSA-162582,R-HSA-199991,R-HSA-5653656,R-HSA-6806834,R-HSA-8854214,R-HSA-8856828,R-HSA-8875656,R-HSA-9006934,R-HSA-9007101","Signal Transduction|Membrane Trafficking|Vesicle-mediated transport|Signaling by MET|TBC/RABGAPs|Clathrin-mediated endocytosis|MET receptor recycling|Signaling by Receptor Tyrosine Kinases|Rab regulation of trafficking"]
["ARFGAP1",24.5148702918738,26.5287173558933,29.7486774271931,31.5011003715791,25.7670902730988,27.2316525255664,27.5290418226392,28.8555709966658,28.4915095000379,36.8746854260661,35.1068198518013,33.0529620275281,25.2010951594426,33.3312417905439,28.4107816677845,27.9076963057398,26.467003157583,31.3965669701348,29.8011364235687,28.2135867744828,27.0084779830029,30.3329129903722,24.2516362310952,24.990753806463,28.384109112004,30.5624410890569,25.5592677785447,32.2886961358861,55738,"ADP ribosylation factor GTPase activating protein 1","protein_coding","hsa04144","Endocytosis","GO:0000139,GO:0005096,GO:0005515,GO:0005829,GO:0015031,GO:0016192,GO:0030100,GO:0032012,GO:0045202,GO:0046872","Golgi membrane|GTPase activator activity|protein binding|cytosol|protein transport|vesicle-mediated transport|regulation of endocytosis|regulation of ARF protein signal transduction|synapse|metal ion binding","WP4754","IL-18 signaling pathway","R-HSA-199977,R-HSA-199991,R-HSA-2262752,R-HSA-381038,R-HSA-381070,R-HSA-381119,R-HSA-392499,R-HSA-446203,R-HSA-5653656,R-HSA-597592,R-HSA-6807878,R-HSA-6811434,R-HSA-6811442,R-HSA-8856688,R-HSA-8856828,R-HSA-8953897,R-HSA-948021","ER to Golgi Anterograde Transport|Membrane Trafficking|Cellular responses to stress|XBP1(S) activates chaperone genes|IRE1alpha activates chaperones|Unfolded Protein Response (UPR)|Metabolism of proteins|Asparagine N-linked glycosylation|Vesicle-mediated transport|Post-translational protein modification|COPI-mediated anterograde transport|COPI-dependent Golgi-to-ER retrograde traffic|Intra-Golgi and retrograde Golgi-to-ER traffic|Golgi-to-ER retrograde transport|Clathrin-mediated endocytosis|Cellular responses to stimuli|Transport to the Golgi and subsequent modification"]
["ARFGAP2",23.965195818897,24.8030813799946,28.3415728636855,27.4245155737254,23.3453917404991,23.8958563989147,26.7482332750084,26.4422610668327,26.0151959830511,28.5933022481246,32.5876164424418,28.461761327091,22.3944055033716,28.0919454477669,26.2231188440892,24.3996264411958,23.8423582790146,27.3235585788684,30.1170175983486,26.3401905412218,24.5948723576966,27.040012157619,23.6497823802744,23.4314339496314,23.8790007125179,27.0210580363781,25.8072480444651,28.9286627476982,84364,"ADP ribosylation factor GTPase activating protein 2","protein_coding","hsa04144","Endocytosis","GO:0000139,GO:0005096,GO:0005794,GO:0005829,GO:0005886,GO:0015031,GO:0046872,GO:0048205","Golgi membrane|GTPase activator activity|Golgi apparatus|cytosol|plasma membrane|protein transport|metal ion binding|COPI coating of Golgi vesicle","WP5380,WP4754","5q35 copy number variation|IL-18 signaling pathway","R-HSA-162582,R-HSA-194315,R-HSA-199977,R-HSA-199991,R-HSA-392499,R-HSA-446203,R-HSA-5653656,R-HSA-597592,R-HSA-6807878,R-HSA-6811434,R-HSA-6811442,R-HSA-8856688,R-HSA-9012999,R-HSA-9013148,R-HSA-948021,R-HSA-9716542","Signal Transduction|Signaling by Rho GTPases|ER to Golgi Anterograde Transport|Membrane Trafficking|Metabolism of proteins|Asparagine N-linked glycosylation|Vesicle-mediated transport|Post-translational protein modification|COPI-mediated anterograde transport|COPI-dependent Golgi-to-ER retrograde traffic|Intra-Golgi and retrograde Golgi-to-ER traffic|Golgi-to-ER retrograde transport|RHO GTPase cycle|CDC42 GTPase cycle|Transport to the Golgi and subsequent modification|Signaling by Rho GTPases, Miro GTPases and RHOBTB3"]
["ARFGAP3",23.9556325280825,23.3920339449479,22.7113506976845,21.5830008953548,24.5486746954623,21.7496979584798,21.7374227676629,22.202333230872,26.1279652721612,19.6157428320889,21.6712589078384,23.8349888673887,27.3696188130362,23.1566170307927,24.1754317862218,24.0059188727294,23.7766784750342,23.8165863940946,24.0253591860813,24.4223793203843,25.442670018925,23.6468667425622,27.4732840760989,25.1954614760582,23.9640482593795,22.6410348398996,23.9120722718291,22.3643499492926,26286,"ADP ribosylation factor GTPase activating protein 3","protein_coding","hsa04144","Endocytosis","GO:0000139,GO:0005096,GO:0005515,GO:0005794,GO:0005829,GO:0006886,GO:0009306,GO:0016020,GO:0016192,GO:0046872,GO:0048205","Golgi membrane|GTPase activator activity|protein binding|Golgi apparatus|cytosol|intracellular protein transport|protein secretion|membrane|vesicle-mediated transport|metal ion binding|COPI coating of Golgi vesicle","WP4352","Ciliary landscape","R-HSA-162582,R-HSA-194315,R-HSA-199977,R-HSA-199991,R-HSA-392499,R-HSA-446203,R-HSA-5653656,R-HSA-597592,R-HSA-6807878,R-HSA-6811434,R-HSA-6811442,R-HSA-8856688,R-HSA-9012999,R-HSA-9013148,R-HSA-9013408,R-HSA-948021,R-HSA-9716542","Signal Transduction|Signaling by Rho GTPases|ER to Golgi Anterograde Transport|Membrane Trafficking|Metabolism of proteins|Asparagine N-linked glycosylation|Vesicle-mediated transport|Post-translational protein modification|COPI-mediated anterograde transport|COPI-dependent Golgi-to-ER retrograde traffic|Intra-Golgi and retrograde Golgi-to-ER traffic|Golgi-to-ER retrograde transport|RHO GTPase cycle|CDC42 GTPase cycle|RHOG GTPase cycle|Transport to the Golgi and subsequent modification|Signaling by Rho GTPases, Miro GTPases and RHOBTB3"]
["ARFGEF1",10.0173015634557,9.42125840850547,8.32644135837184,6.73100842951786,11.1972954652064,9.0257976657212,8.32992351223813,7.62577982231237,11.0522626489385,8.25936256848056,7.38687983263756,8.84122033842109,12.2863398629064,9.00284080073403,10.511737277852,11.0276514015531,8.31388798133385,7.66613163862918,7.18736564817393,9.37177239242217,9.34881160454596,7.98823863712598,9.73216249788062,9.81101971998111,9.09294131297464,6.84660814570928,8.86009387760652,6.92077872266211,10565,"ADP ribosylation factor guanine nucleotide exchange factor 1","protein_coding","hsa04144","Endocytosis","GO:0000139,GO:0005085,GO:0005096,GO:0005515,GO:0005654,GO:0005730,GO:0005794,GO:0005802,GO:0005829,GO:0006486,GO:0006887,GO:0007030,GO:0010256,GO:0015031,GO:0016363,GO:0017022,GO:0030532,GO:0030837,GO:0032012,GO:0034237,GO:0034260,GO:0048471,GO:0090303,GO:2000114","Golgi membrane|guanyl-nucleotide exchange factor activity|GTPase activator activity|protein binding|nucleoplasm|nucleolus|Golgi apparatus|trans-Golgi network|cytosol|protein glycosylation|exocytosis|Golgi organization|endomembrane system organization|protein transport|nuclear matrix|myosin binding|small nuclear ribonucleoprotein complex|negative regulation of actin filament polymerization|regulation of ARF protein signal transduction|protein kinase A regulatory subunit binding|negative regulation of GTPase activity|perinuclear region of cytoplasm|positive regulation of wound healing|regulation of establishment of cell polarity"]
["ARFGEF1-DT",0.0170124425593203,0.0566357940740005,0.087845394965809,0.0652636902139041,0.0166238427392772,0.0559144268599929,0.0317449105487957,0.066729392540329,0.154009899553905,0.0983109763753048,0.207989842984073,0.0684637228578715,0.0404467050730681,0.121644608882595,0.0711966438622403,0.0161303797709983,0.0245346495032552,0.0550935487513336,0.141509360143772,0.0408988138906812,0.0722575039982092,0.040427384196569,0.134360208468082,0.0831034530062309,0.0421663264657776,0.105071722599915,0.0905444551418055,0.191923972918621,102724708,"ARFGEF1 divergent transcript","non_coding"]
["ARFGEF2",7.5785439577325,7.65986818692013,5.6662256121795,4.15942838030483,8.33001965574345,6.67657899282494,5.33575669499004,4.95530669800952,6.64121671139013,5.42186685744916,3.33200692204807,5.18019395132912,7.45692222799699,4.40797803739206,6.4123229833377,6.74694616379118,4.84414843751437,4.37742154402878,4.00558244843831,5.84392830745304,5.47675235486549,4.83461198990703,6.57999867760178,5.82932488440831,5.98065117927294,3.84298060088264,5.0344607408246,3.97625502179439,10564,"ADP ribosylation factor guanine nucleotide exchange factor 2","protein_coding","hsa04144","Endocytosis","GO:0000139,GO:0001881,GO:0005085,GO:0005515,GO:0005794,GO:0005802,GO:0005815,GO:0005829,GO:0005879,GO:0006887,GO:0006893,GO:0007032,GO:0010256,GO:0015031,GO:0016020,GO:0017022,GO:0031410,GO:0032012,GO:0032279,GO:0032280,GO:0032760,GO:0034237,GO:0035556,GO:0043197,GO:0043231,GO:0048471,GO:0050811,GO:0055037,GO:0098793,GO:0098978,GO:0098982","Golgi membrane|receptor recycling|guanyl-nucleotide exchange factor activity|protein binding|Golgi apparatus|trans-Golgi network|microtubule organizing center|cytosol|axonemal microtubule|exocytosis|Golgi to plasma membrane transport|endosome organization|endomembrane system organization|protein transport|membrane|myosin binding|cytoplasmic vesicle|regulation of ARF protein signal transduction|asymmetric synapse|symmetric synapse|positive regulation of tumor necrosis factor production|protein kinase A regulatory subunit binding|intracellular signal transduction|dendritic spine|intracellular membrane-bounded organelle|perinuclear region of cytoplasm|GABA receptor binding|recycling endosome|presynapse|glutamatergic synapse|GABA-ergic synapse",null,null,"R-HSA-390466,R-HSA-390471,R-HSA-391251,R-HSA-392499","Chaperonin-mediated protein folding|Association of TriC/CCT with target proteins during biosynthesis|Protein folding|Metabolism of proteins"]
["ARFGEF3",0.00725653549639763,0,0,0,0,5.110692472652E-3,0,0,0.00729909103627921,0,0.00341217605707253,0.00547550822068935,0.00517567568651536,0.00345910909705853,0.00337426870956531,3.44014896657203E-3,0.00174417982986328,0.00167855418065988,0,0,0.00171227337094858,0,0.00358189902277537,0.00354471825259769,0,0,0.00175550403088658,1.7054957438228E-3,57221,"ARFGEF family member 3","protein_coding",null,null,"GO:0005085,GO:0030658,GO:0032012","guanyl-nucleotide exchange factor activity|transport vesicle membrane|regulation of ARF protein signal transduction"]
["ARFIP1",12.7156128712844,11.162682171275,11.7511270899315,9.66557214081018,12.108413603686,11.3594896473321,11.8360582312905,11.2263357976329,12.2418204431358,7.01741053584481,8.70891168465088,10.6138604140066,12.3656708819139,9.00428975920101,11.839151561818,11.6022991492241,12.6644387396518,9.9998307867761,12.7597474437761,12.348037100066,11.806956461365,12.1006640905551,17.149612710067,13.4304492005522,13.2639060313314,11.2631112508858,14.0298845830143,10.1672585750084,27236,"ADP ribosylation factor interacting protein 1","protein_coding",null,null,"GO:0000139,GO:0005515,GO:0005543,GO:0005829,GO:0006886,GO:0019904,GO:0032588,GO:0034315,GO:0050708,GO:0070273,GO:1905280","Golgi membrane|protein binding|phospholipid binding|cytosol|intracellular protein transport|protein domain specific binding|trans-Golgi network membrane|regulation of Arp2/3 complex-mediated actin nucleation|regulation of protein secretion|phosphatidylinositol-4-phosphate binding|negative regulation of retrograde transport, endosome to Golgi"]
["ARFIP2",22.7687176666329,24.3852474044015,25.3555498798437,26.9333521967507,22.7366508392585,23.2689585491604,23.2621690162973,25.8806580797615,22.2066748162372,25.9129558259758,25.9167885313424,24.4919170568448,22.712352458173,25.3453968417928,21.5916064426594,23.0573663813928,30.7184495911576,27.2876907466457,32.5355041739416,26.3280411902554,30.180687428625,29.4693506162777,30.0377405436342,29.6008340872485,27.7533913172568,30.0423380720387,30.6700523170954,30.8557941581367,23647,"ADP ribosylation factor interacting protein 2","protein_coding",null,null,"GO:0000423,GO:0001726,GO:0005515,GO:0005525,GO:0005543,GO:0005730,GO:0005737,GO:0005794,GO:0005829,GO:0005886,GO:0005938,GO:0006886,GO:0007264,GO:0019904,GO:0030032,GO:0030036,GO:0030742,GO:0031267,GO:0031529,GO:0032588,GO:0034315,GO:0034497,GO:0042802,GO:0045296,GO:0070273,GO:0140090","mitophagy|ruffle|protein binding|GTP binding|phospholipid binding|nucleolus|cytoplasm|Golgi apparatus|cytosol|plasma membrane|cell cortex|intracellular protein transport|small GTPase mediated signal transduction|protein domain specific binding|lamellipodium assembly|actin cytoskeleton organization|GTP-dependent protein binding|small GTPase binding|ruffle organization|trans-Golgi network membrane|regulation of Arp2/3 complex-mediated actin nucleation|protein localization to phagophore assembly site|identical protein binding|cadherin binding|phosphatidylinositol-4-phosphate binding|membrane curvature sensor activity","WP2526","PDGF pathway","R-HSA-199991,R-HSA-5653656,R-HSA-6811440,R-HSA-6811442","Membrane Trafficking|Vesicle-mediated transport|Retrograde transport at the Trans-Golgi-Network|Intra-Golgi and retrograde Golgi-to-ER traffic"]
["ARFRP1",10.3774195324227,10.8705553403169,11.5626568982849,11.571226005998,8.62309056195067,9.85360525257437,10.734825445819,11.1690827593075,11.0494403965558,13.81249579327,14.1401924804922,12.1774029454126,9.85966218281176,12.8267385316822,10.5478698204627,10.4703333901549,11.6926814182234,13.8316768100748,12.1670625429043,12.1586071798822,10.413744007746,13.0635414840408,8.70236528579414,11.024156200887,11.3402042965351,13.1227829291921,10.0607037845257,12.1949688340922,10139,"ADP ribosylation factor related protein 1","protein_coding",null,null,"GO:0003924,GO:0005515,GO:0005525,GO:0005794,GO:0005802,GO:0005829,GO:0006886,GO:0007165,GO:0007369,GO:0016020,GO:0032588,GO:0034067,GO:0042147,GO:0043001","GTPase activity|protein binding|GTP binding|Golgi apparatus|trans-Golgi network|cytosol|intracellular protein transport|signal transduction|gastrulation|membrane|trans-Golgi network membrane|protein localization to Golgi apparatus|retrograde transport, endosome to Golgi|Golgi to plasma membrane protein transport",null,null,"R-HSA-199991,R-HSA-199991,R-HSA-5653656,R-HSA-5653656,R-HSA-6811440,R-HSA-6811440,R-HSA-6811442,R-HSA-6811442","Membrane Trafficking|Membrane Trafficking|Vesicle-mediated transport|Vesicle-mediated transport|Retrograde transport at the Trans-Golgi-Network|Retrograde transport at the Trans-Golgi-Network|Intra-Golgi and retrograde Golgi-to-ER traffic|Intra-Golgi and retrograde Golgi-to-ER traffic"]
["ARG1",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.0180909033240718,0,0,0,0,0,383,"arginase 1","protein_coding","hsa00220,hsa00330,hsa05146","Arginine biosynthesis|Arginine and proline metabolism|Amoebiasis","GO:0000050,GO:0002250,GO:0004053,GO:0005515,GO:0005576,GO:0005615,GO:0005634,GO:0005737,GO:0005829,GO:0006527,GO:0019547,GO:0030145,GO:0035578,GO:0035580,GO:0042130,GO:0042832,GO:0045087,GO:0046007,GO:0060336,GO:0070965,GO:2000552","urea cycle|adaptive immune response|arginase activity|protein binding|extracellular region|extracellular space|nucleus|cytoplasm|cytosol|arginine catabolic process|arginine catabolic process to ornithine|manganese ion binding|azurophil granule lumen|specific granule lumen|negative regulation of T cell proliferation|defense response to protozoan|innate immune response|negative regulation of activated T cell proliferation|negative regulation of type II interferon-mediated signaling pathway|positive regulation of neutrophil mediated killing of fungus|negative regulation of T-helper 2 cell cytokine production","WP497,WP4754,WP4583,WP4571,WP5355,WP2431,WP5078,WP4595,WP3925","Urea cycle and metabolism of amino groups|IL-18 signaling pathway|Biomarkers for urea cycle disorders|Urea cycle and related diseases|Metabolic Epileptic Disorders|Spinal cord injury|T cell modulation in pancreatic cancer|Urea cycle and associated pathways|Amino acid metabolism","R-HSA-1430728,R-HSA-168249,R-HSA-168256,R-HSA-6798695,R-HSA-70635,R-HSA-71291","Metabolism|Innate Immune System|Immune System|Neutrophil degranulation|Urea cycle|Metabolism of amino acids and derivatives"]
["ARG2",2.94811563797269,1.12702562901417,1.86726939665941,1.7992637598303,2.16402677906877,1.66900614178321,2.14517769613406,3.22288387465662,2.80933076323893,1.67104223567071,1.22044484849496,3.0511990197127,1.59632625816952,1.99032901800955,1.52172632538723,2.43415111877589,2.63100628458194,1.6314518949781,1.94249756328992,1.99397448030105,1.03847632730306,1.90394997736134,2.79903478635878,2.4805793649301,3.31440565056009,2.34553598844134,3.00298669120232,2.06873153122147,384,"arginase 2","protein_coding","hsa00220,hsa00330,hsa05146","Arginine biosynthesis|Arginine and proline metabolism|Amoebiasis","GO:0000050,GO:0001657,GO:0002250,GO:0002829,GO:0004053,GO:0005515,GO:0005737,GO:0005739,GO:0005759,GO:0006809,GO:0006941,GO:0019547,GO:0030145,GO:0032651,GO:0032696,GO:0032700,GO:0032720,GO:0045087,GO:0071641,GO:0071644,GO:0071650,GO:1900425,GO:1903426,GO:1905403,GO:2000562,GO:2000774","urea cycle|ureteric bud development|adaptive immune response|negative regulation of type 2 immune response|arginase activity|protein binding|cytoplasm|mitochondrion|mitochondrial matrix|nitric oxide biosynthetic process|striated muscle contraction|arginine catabolic process to ornithine|manganese ion binding|regulation of interleukin-1 beta production|negative regulation of interleukin-13 production|negative regulation of interleukin-17 production|negative regulation of tumor necrosis factor production|innate immune response|negative regulation of macrophage inflammatory protein 1 alpha production|negative regulation of chemokine (C-C motif) ligand 4 production|negative regulation of chemokine (C-C motif) ligand 5 production|negative regulation of defense response to bacterium|regulation of reactive oxygen species biosynthetic process|negative regulation of activated CD8-positive, alpha-beta T cell apoptotic process|negative regulation of CD4-positive, alpha-beta T cell proliferation|positive regulation of cellular senescence","WP497,WP5381,WP3925","Urea cycle and metabolism of amino groups|Smith-Magenis and Potocki-Lupski syndrome copy number variation|Amino acid metabolism","R-HSA-1430728,R-HSA-70635,R-HSA-71291","Metabolism|Urea cycle|Metabolism of amino acids and derivatives"]
["ARGLU1",22.5717223022434,19.8988891724024,20.9503323792141,18.9647080281057,22.7140614270342,19.2013457607144,19.8851021146273,17.3470204069055,23.8892852332009,19.631907328553,22.3656589061945,23.8541565798709,25.5665174246183,22.8337673795271,23.8167910680348,24.5325953076985,26.8646605912869,23.1023484736468,26.8099878472897,24.5573699152867,25.6393721956993,25.0514471094994,32.6256665387966,27.4083243835447,27.5276423911181,24.2118737042,31.3516827310029,23.4128675667373,55082,"arginine and glutamate rich 1","protein_coding",null,null,"GO:0005515,GO:0005654,GO:0005739,GO:0005829,GO:0045296","protein binding|nucleoplasm|mitochondrion|cytosol|cadherin binding"]
["ARHGAP1",31.784288527377,37.0874768347809,35.6324279933119,38.3783360104589,32.0043000878666,39.0810586424196,33.0491010164372,36.1936015391269,40.3977587127428,55.6604689473748,50.064779540089,44.1944540776831,38.2240124135147,45.5712800775701,40.1341460929623,42.9276263323559,30.2909831760005,35.9194695679715,33.1010471908344,35.1585443928013,32.6753163552907,35.1743144260416,26.9428035539948,28.9813967605583,31.0913586362988,36.1892417299433,25.7972417619479,35.3478717821233,392,"Rho GTPase activating protein 1","protein_coding",null,null,"GO:0005096,GO:0005515,GO:0005737,GO:0005829,GO:0007264,GO:0007266,GO:0010008,GO:0016197,GO:0017124,GO:0031267,GO:0033572,GO:0045296,GO:0048471,GO:0051056,GO:0070062,GO:0097443,GO:2001136","GTPase activator activity|protein binding|cytoplasm|cytosol|small GTPase mediated signal transduction|Rho protein signal transduction|endosome membrane|endosomal transport|SH3 domain binding|small GTPase binding|transferrin transport|cadherin binding|perinuclear region of cytoplasm|regulation of small GTPase mediated signal transduction|extracellular exosome|sorting endosome|negative regulation of endocytic recycling",null,null,"R-HSA-162582,R-HSA-194315,R-HSA-8980692,R-HSA-9012999,R-HSA-9013026,R-HSA-9013106,R-HSA-9013148,R-HSA-9013149,R-HSA-9013404,R-HSA-9013405,R-HSA-9013406,R-HSA-9013408,R-HSA-9013409,R-HSA-9013423,R-HSA-9035034,R-HSA-9696270,R-HSA-9716542","Signal Transduction|Signaling by Rho GTPases|RHOA GTPase cycle|RHO GTPase cycle|RHOB GTPase cycle|RHOC GTPase cycle|CDC42 GTPase cycle|RAC1 GTPase cycle|RAC2 GTPase cycle|RHOD GTPase cycle|RHOQ GTPase cycle|RHOG GTPase cycle|RHOJ GTPase cycle|RAC3 GTPase cycle|RHOF GTPase cycle|RND2 GTPase cycle|Signaling by Rho GTPases, Miro GTPases and RHOBTB3"]
["ARHGAP10",11.003489706303,11.2655386597662,10.6007863792328,11.3067718297528,10.3187152884706,10.522833180296,9.90313826253886,11.606486063244,10.8175405387237,10.8151226810145,12.067958015132,12.1743357094545,9.19874602840965,10.4385472310886,9.97265019702424,9.05322919709851,10.0704300957705,10.6779581506756,8.32847674394283,9.81790667898812,10.84839018994,10.363062765994,6.8296241351189,8.70500273528793,10.5850820737937,9.51624035883203,8.29088420000956,10.1616582524873,79658,"Rho GTPase activating protein 10","protein_coding","hsa05100","Bacterial invasion of epithelial cells","GO:0005096,GO:0005515,GO:0005829,GO:0005886,GO:0007010,GO:0007165,GO:0043066,GO:0048471,GO:0051056","GTPase activator activity|protein binding|cytosol|plasma membrane|cytoskeleton organization|signal transduction|negative regulation of apoptotic process|perinuclear region of cytoplasm|regulation of small GTPase mediated signal transduction","WP2858","Ectoderm differentiation","R-HSA-109581,R-HSA-162582,R-HSA-169911,R-HSA-194315,R-HSA-211728,R-HSA-5357801,R-HSA-8980692,R-HSA-9012999,R-HSA-9013148,R-HSA-9013149,R-HSA-9716542","Apoptosis|Signal Transduction|Regulation of Apoptosis|Signaling by Rho GTPases|Regulation of PAK-2p34 activity by PS-GAP/RHG10|Programmed Cell Death|RHOA GTPase cycle|RHO GTPase cycle|CDC42 GTPase cycle|RAC1 GTPase cycle|Signaling by Rho GTPases, Miro GTPases and RHOBTB3"]
["ARHGAP11A",9.1578696672515,6.79545799432824,2.88615143356395,5.30531977349902,7.09069511431665,4.34439024051338,2.25271065484304,4.02078611158924,5.54689502369742,3.2764310751387,2.01524771624474,4.29446421863461,4.39552950030917,1.66068109705453,1.78034124179553,1.51667237415091,7.28339116083431,6.83780631505259,4.95321364481989,8.07668102033653,7.69140216503011,7.49997813018672,6.77211205924953,6.95455606356697,7.89952538955378,6.96457614994003,4.78142185166436,5.6747833909866,9824,"Rho GTPase activating protein 11A","protein_coding",null,null,"GO:0005096,GO:0005634,GO:0005829,GO:0007165,GO:0043547,GO:0051056","GTPase activator activity|nucleus|cytosol|signal transduction|positive regulation of GTPase activity|regulation of small GTPase mediated signal transduction",null,null,"R-HSA-162582,R-HSA-194315,R-HSA-8980692,R-HSA-9012999,R-HSA-9716542","Signal Transduction|Signaling by Rho GTPases|RHOA GTPase cycle|RHO GTPase cycle|Signaling by Rho GTPases, Miro GTPases and RHOBTB3"]
["ARHGAP11B",2.82480466362931,2.4902585464096,0.776203236656354,1.50324901918494,2.22168894842862,1.92477822251016,0.530317493683932,1.16542457685789,2.30428223053892,1.39350312391909,0.50215566932692,1.23037293764362,1.17937939975869,0.5419053573212,0.720837585940701,0.84923099734929,2.83180021963035,2.54994367493165,1.48048328340405,2.58388514124635,2.48736646191407,2.40674938482841,2.0745237650764,2.62513453303337,3.22749415204336,2.30764771381655,1.91679166480417,1.70025938149113,89839,"Rho GTPase activating protein 11B","protein_coding",null,null,"GO:0005096,GO:0005515,GO:0005759,GO:0005829,GO:0006543,GO:0007165,GO:0021987,GO:0035795,GO:0043547,GO:0051056","GTPase activator activity|protein binding|mitochondrial matrix|cytosol|glutamine catabolic process|signal transduction|cerebral cortex development|negative regulation of mitochondrial membrane permeability|positive regulation of GTPase activity|regulation of small GTPase mediated signal transduction","WP4942","15q13.3 copy number variation syndrome","R-HSA-162582,R-HSA-194315,R-HSA-8980692,R-HSA-9012999,R-HSA-9013148,R-HSA-9716542","Signal Transduction|Signaling by Rho GTPases|RHOA GTPase cycle|RHO GTPase cycle|CDC42 GTPase cycle|Signaling by Rho GTPases, Miro GTPases and RHOBTB3"]
["ARHGAP11B-DT",0.0562973927449542,0.0778882340917335,0.0816834658852379,0.127618580109275,0.135028085845906,0.0817021866128292,0.157574877086644,0.110410095621954,0.0926632564431987,0.0936554996287177,0.0529444431699684,0.0514907769452712,0.141146483498007,0.107345343232413,0.147549460928266,0.106756960022257,0.137776629309717,0.142063622007358,0.184474435473799,0.0984304850727692,0.140086848404941,0.0972959031850596,0.282942140160194,0.340006252045162,0.172517676528637,0.0632185853273463,0.168386400119249,0.125097967095887,102725021,"ARHGAP11B divergent transcript","non_coding"]
["ARHGAP12",9.4095936433307,9.39206421593254,9.00757184448331,6.85181974024186,10.3917187745847,8.1666873493974,9.40966097554582,7.41475311418103,8.02540742864339,5.31959954951803,6.17754122388429,6.40684658448416,10.2841780981461,7.63180563594124,9.23211816456516,8.95677016467107,6.32562057640656,6.06318726423069,7.56921694113071,7.74857311267628,7.11198631087287,6.79595969530372,10.9157569335263,8.13021022332912,6.75323660158133,5.08752958583592,8.54853330905797,5.33149194721161,94134,"Rho GTPase activating protein 12","protein_coding",null,null,"GO:0001891,GO:0002011,GO:0005096,GO:0005737,GO:0006911,GO:0007015,GO:0007165,GO:0043087,GO:0051058","phagocytic cup|morphogenesis of an epithelial sheet|GTPase activator activity|cytoplasm|phagocytosis, engulfment|actin filament organization|signal transduction|regulation of GTPase activity|negative regulation of small GTPase mediated signal transduction",null,null,"R-HSA-162582,R-HSA-194315,R-HSA-9012999,R-HSA-9013149,R-HSA-9013405,R-HSA-9013424,R-HSA-9035034,R-HSA-9716542","Signal Transduction|Signaling by Rho GTPases|RHO GTPase cycle|RAC1 GTPase cycle|RHOD GTPase cycle|RHOV GTPase cycle|RHOF GTPase cycle|Signaling by Rho GTPases, Miro GTPases and RHOBTB3"]
["ARHGAP15",0.00723074443005448,0.00687763762341001,0.00678848167788355,6.93470474409409E-3,0,0.00679003750457225,0,0,0.00727314871969372,0.0139282673521701,0,0.007274729671962,0.00687637383994382,6.89362956990245E-3,0.0134491037434096,0.00685584408453511,0,0,0,0.00695323718989103,0,0,0.0285533463408902,0,0,0.00687050777730135,0,0.00679773638880446,55843,"Rho GTPase activating protein 15","protein_coding",null,null,"GO:0005096,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0007165,GO:0008360,GO:0043087,GO:0051056","GTPase activator activity|nucleoplasm|cytoplasm|cytosol|plasma membrane|signal transduction|regulation of cell shape|regulation of GTPase activity|regulation of small GTPase mediated signal transduction","WP2858","Ectoderm differentiation","R-HSA-162582,R-HSA-194315,R-HSA-9012999,R-HSA-9013149,R-HSA-9013423,R-HSA-9716542","Signal Transduction|Signaling by Rho GTPases|RHO GTPase cycle|RAC1 GTPase cycle|RAC3 GTPase cycle|Signaling by Rho GTPases, Miro GTPases and RHOBTB3"]
["ARHGAP15-AS1",0,0,0,0,0,0,0,0.002591996530696,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,105373654,null,"non_coding"]
["ARHGAP17",18.9124540838655,23.0537736370393,23.5953929261053,21.5787949612151,19.9189746356366,22.0377924950857,21.6975936471508,20.2556845341741,21.7581405827634,28.3254016427094,26.9909220185328,23.8977929942337,21.5107995164783,21.8619192335916,22.5097963662144,21.515740184191,19.2989070145874,21.6651706593287,20.647875000327,21.4642891289086,20.4980920816677,20.5361206263549,17.5774821526126,18.0364054547026,17.5997226126456,20.2196626954583,18.3654042898718,21.0902472162355,55114,"Rho GTPase activating protein 17","protein_coding","hsa04530","Tight junction","GO:0005096,GO:0005515,GO:0005622,GO:0005829,GO:0005886,GO:0005923,GO:0007015,GO:0007165,GO:0017124,GO:0017156,GO:0032956,GO:0035020","GTPase activator activity|protein binding|intracellular anatomical structure|cytosol|plasma membrane|bicellular tight junction|actin filament organization|signal transduction|SH3 domain binding|calcium-ion regulated exocytosis|regulation of actin cytoskeleton organization|regulation of Rac protein signal transduction",null,null,"R-HSA-162582,R-HSA-194315,R-HSA-9012999,R-HSA-9013148,R-HSA-9013149,R-HSA-9013404,R-HSA-9013405,R-HSA-9013406,R-HSA-9013423,R-HSA-9716542","Signal Transduction|Signaling by Rho GTPases|RHO GTPase cycle|CDC42 GTPase cycle|RAC1 GTPase cycle|RAC2 GTPase cycle|RHOD GTPase cycle|RHOQ GTPase cycle|RAC3 GTPase cycle|Signaling by Rho GTPases, Miro GTPases and RHOBTB3"]
["ARHGAP18",5.41689236829647,4.67604567588545,3.31966904474213,3.71916353570436,4.49948369519034,3.49820763216984,2.79759935267358,2.57504931278121,1.95955169873557,1.37634253298598,1.5621674826365,1.41315002490419,1.75392087583683,1.18191856828932,1.51073593440696,1.58655477315773,3.92215701980402,3.6446206587957,4.55487126784174,4.53364927147744,4.99746146497688,4.10407190878484,5.54662013741116,4.71341924865494,4.13529386014244,3.78918310034843,4.40857173960763,3.54236295782843,93663,"Rho GTPase activating protein 18","protein_coding",null,null,"GO:0001726,GO:0005096,GO:0005737,GO:0005829,GO:0005881,GO:0005886,GO:0007264,GO:0008360,GO:0016607,GO:0030833,GO:0032956,GO:0045296,GO:0051056,GO:2000145","ruffle|GTPase activator activity|cytoplasm|cytosol|cytoplasmic microtubule|plasma membrane|small GTPase mediated signal transduction|regulation of cell shape|nuclear speck|regulation of actin filament polymerization|regulation of actin cytoskeleton organization|cadherin binding|regulation of small GTPase mediated signal transduction|regulation of cell motility",null,null,"R-HSA-162582,R-HSA-194315,R-HSA-8980692,R-HSA-9012999,R-HSA-9013106,R-HSA-9716542","Signal Transduction|Signaling by Rho GTPases|RHOA GTPase cycle|RHO GTPase cycle|RHOC GTPase cycle|Signaling by Rho GTPases, Miro GTPases and RHOBTB3"]
["ARHGAP19",2.87238359064066,2.06426342669436,1.58114001374069,2.46282312687959,2.09668292249693,1.70138303688337,1.57587749572049,1.69961981035944,2.50893690362937,2.03347629291646,1.58384542285883,2.20320687227962,2.03119816553007,1.78351381510805,1.55711714349744,1.42923244651622,3.01654185988137,3.13928431150524,2.32344564961906,2.92740151388461,2.97526305139341,2.69763613624553,2.43334842120842,3.11324759257391,3.35888200777173,2.79459718456719,2.63226030142055,2.41417955148509,84986,"Rho GTPase activating protein 19","protein_coding",null,null,"GO:0005096,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0007165,GO:0043231,GO:0051056","GTPase activator activity|protein binding|nucleus|cytoplasm|cytosol|plasma membrane|signal transduction|intracellular membrane-bounded organelle|regulation of small GTPase mediated signal transduction",null,null,"R-HSA-162582,R-HSA-194315,R-HSA-8980692,R-HSA-9012999,R-HSA-9716542","Signal Transduction|Signaling by Rho GTPases|RHOA GTPase cycle|RHO GTPase cycle|Signaling by Rho GTPases, Miro GTPases and RHOBTB3"]
["ARHGAP20",0.0817917237306899,0.15929964189902,0.0731323788329717,0.0747076413407969,0.0494764087075571,0.0841215107342932,0.105381773744577,0.0611083499379577,0.21939036438564,0.0525172756570193,0.0549431339749032,0.137148783065684,0.13704659759955,0.122537477851131,0.112287676738792,0.107094208303317,0.0561698484870797,0.0108112858996208,0.00359969787840241,0.0411990103573257,0.0220569310957304,0.0444263131405036,0.0269154791977991,0.0266360915768996,0.0386143876809852,0.0148032093592136,0.0113069069765686,0.0512624559463202,57569,"Rho GTPase activating protein 20","protein_coding",null,null,"GO:0005096,GO:0005829,GO:0007165,GO:0035023,GO:0051056","GTPase activator activity|cytosol|signal transduction|regulation of Rho protein signal transduction|regulation of small GTPase mediated signal transduction",null,null,"R-HSA-162582,R-HSA-194315,R-HSA-8980692,R-HSA-9012999,R-HSA-9013148,R-HSA-9013149,R-HSA-9716542","Signal Transduction|Signaling by Rho GTPases|RHOA GTPase cycle|RHO GTPase cycle|CDC42 GTPase cycle|RAC1 GTPase cycle|Signaling by Rho GTPases, Miro GTPases and RHOBTB3"]
["ARHGAP21",22.7023016998038,24.1612195048132,19.7503382160456,17.3277905523974,24.492555636896,20.6843830937443,19.1914459127602,17.7647129427856,17.5252854697921,16.2581565181717,12.278657097384,15.1162822798693,17.8875152805461,15.8613304557585,18.4460849286287,18.0965628171904,14.6584201357921,14.9776853142042,12.3779596263309,17.357062174989,15.7571912653146,14.0143850405819,15.8559760438482,16.1046040264626,16.443800433577,12.380545520036,14.3207331686034,12.1515672274551,57584,"Rho GTPase activating protein 21","protein_coding",null,null,"GO:0000139,GO:0005096,GO:0005515,GO:0005794,GO:0005829,GO:0005886,GO:0007030,GO:0007165,GO:0015629,GO:0030054,GO:0030659,GO:0051056,GO:0051645,GO:0051683,GO:0051684,GO:0070161,GO:0072384","Golgi membrane|GTPase activator activity|protein binding|Golgi apparatus|cytosol|plasma membrane|Golgi organization|signal transduction|actin cytoskeleton|cell junction|cytoplasmic vesicle membrane|regulation of small GTPase mediated signal transduction|Golgi localization|establishment of Golgi localization|maintenance of Golgi location|anchoring junction|organelle transport along microtubule",null,null,"R-HSA-162582,R-HSA-194315,R-HSA-8980692,R-HSA-9012999,R-HSA-9013026,R-HSA-9013106,R-HSA-9013148,R-HSA-9013149,R-HSA-9013404,R-HSA-9013405,R-HSA-9013406,R-HSA-9013408,R-HSA-9013409,R-HSA-9013423,R-HSA-9035034,R-HSA-9696264,R-HSA-9716542","Signal Transduction|Signaling by Rho GTPases|RHOA GTPase cycle|RHO GTPase cycle|RHOB GTPase cycle|RHOC GTPase cycle|CDC42 GTPase cycle|RAC1 GTPase cycle|RAC2 GTPase cycle|RHOD GTPase cycle|RHOQ GTPase cycle|RHOG GTPase cycle|RHOJ GTPase cycle|RAC3 GTPase cycle|RHOF GTPase cycle|RND3 GTPase cycle|Signaling by Rho GTPases, Miro GTPases and RHOBTB3"]
["ARHGAP22",9.74212525264489,7.94893902818608,7.36773624995895,9.69471723224354,7.91428211561793,7.80686595970397,6.49609307224418,7.30566823818787,4.27643715974515,4.31309017012555,3.6887111090131,3.79932646727677,3.50858577768075,3.92301527920393,3.35314046169674,2.94453764368051,8.01389464962709,7.81006546064697,7.80986843706075,7.4480000691614,7.97281825477834,8.4189450055295,6.34021134298612,7.25136029675602,7.57106204593896,8.06463369032249,6.25680202883329,8.03176675337337,58504,"Rho GTPase activating protein 22","protein_coding",null,null,"GO:0001525,GO:0005096,GO:0005515,GO:0005634,GO:0005829,GO:0005925,GO:0007165,GO:0030154,GO:0051056,GO:0090630,GO:0098978,GO:0099175","angiogenesis|GTPase activator activity|protein binding|nucleus|cytosol|focal adhesion|signal transduction|cell differentiation|regulation of small GTPase mediated signal transduction|activation of GTPase activity|glutamatergic synapse|regulation of postsynapse organization","WP5352","10q11.21q11.23 copy number variation syndrome","R-HSA-162582,R-HSA-194315,R-HSA-8980692,R-HSA-9012999,R-HSA-9013148,R-HSA-9013149,R-HSA-9716542","Signal Transduction|Signaling by Rho GTPases|RHOA GTPase cycle|RHO GTPase cycle|CDC42 GTPase cycle|RAC1 GTPase cycle|Signaling by Rho GTPases, Miro GTPases and RHOBTB3"]
["ARHGAP22-IT1",0.0235837403632923,0.0224320499213233,0.0442825191516183,0,0,0.0885853361926347,0.0220034167824002,0.0231261422747487,0.0474440917358148,0.0227141647807918,0,0,0,0,0,0,0.0453486755764454,0,0,0.0907144995412555,0.0222595538223316,0,0.0698470309441198,0.023040668641885,0.0233814678162816,0,0,0,100689073,"ARHGAP22 intronic transcript 1","non_coding"]
["ARHGAP23",13.9160884861326,16.8694652195004,14.8062456603514,15.6931720596664,14.9774436865811,15.642202520808,13.6221760898383,13.6843265017561,14.8074533312133,19.4247526889697,17.2929484348198,15.4636117706617,14.3402890887278,16.5739651337186,14.1588965160548,15.0271443458754,11.098418647449,12.8760665573409,10.6851781862306,12.024707568483,13.3154770866048,12.6782840450384,8.77020859995036,9.90222523463149,12.4184663288886,11.982729594248,7.7764357241077,12.0391819629915,57636,"Rho GTPase activating protein 23","protein_coding",null,null,"GO:0005096,GO:0005829,GO:0007165,GO:0051056,GO:0070062","GTPase activator activity|cytosol|signal transduction|regulation of small GTPase mediated signal transduction|extracellular exosome","WP5287","17q12 copy number variation syndrome","R-HSA-162582,R-HSA-194315,R-HSA-8980692,R-HSA-9012999,R-HSA-9013149,R-HSA-9716542","Signal Transduction|Signaling by Rho GTPases|RHOA GTPase cycle|RHO GTPase cycle|RAC1 GTPase cycle|Signaling by Rho GTPases, Miro GTPases and RHOBTB3"]
["ARHGAP24",1.3923561289116,1.50719673472739,1.41076494487131,1.26481584030758,1.58431602007647,1.51311356505436,1.29593671313186,1.50302143167202,1.13151378690291,1.27984255123915,1.0830703186605,1.12671475075586,1.31776002163033,1.38002880868682,1.51406535709647,1.48974214313375,0.933691465332444,0.776381320664317,0.872830197450181,0.819746437923731,0.853505579477797,0.751511155025145,0.933976116759203,1.01572959684216,0.977724341245477,0.759170021146312,0.85887972119521,0.857984178494129,83478,"Rho GTPase activating protein 24","protein_coding",null,null,"GO:0001525,GO:0005096,GO:0005515,GO:0005737,GO:0005856,GO:0005912,GO:0005925,GO:0007165,GO:0030154,GO:0035021,GO:0035313,GO:0042995,GO:0090630,GO:1900028","angiogenesis|GTPase activator activity|protein binding|cytoplasm|cytoskeleton|adherens junction|focal adhesion|signal transduction|cell differentiation|negative regulation of Rac protein signal transduction|wound healing, spreading of epidermal cells|cell projection|activation of GTPase activity|negative regulation of ruffle assembly","WP4758","Nephrotic syndrome","R-HSA-162582,R-HSA-194315,R-HSA-8980692,R-HSA-9012999,R-HSA-9013148,R-HSA-9013149,R-HSA-9716542","Signal Transduction|Signaling by Rho GTPases|RHOA GTPase cycle|RHO GTPase cycle|CDC42 GTPase cycle|RAC1 GTPase cycle|Signaling by Rho GTPases, Miro GTPases and RHOBTB3"]
["ARHGAP25",0.00542269467617041,0.0257894116476287,0.0101820397083684,0.0416054384002941,0.0476894607490371,0.0203687465838224,0.0202373006495944,0.015952432480409,0,0.00522275001899921,0.00509973084208818,0,0.0206277382219356,0.0258493774256652,0.0201723028587531,0.0154246148142105,0,0.0250871419939903,0,0.0104291564047128,0.0255910983895846,0.0103089423068941,0,0.00529782423208098,0.0268809270911384,0.0103050706070325,0,0,9938,"Rho GTPase activating protein 25","protein_coding",null,null,"GO:0001891,GO:0005096,GO:0006911,GO:0007015,GO:0007165,GO:0051058,GO:0090630","phagocytic cup|GTPase activator activity|phagocytosis, engulfment|actin filament organization|signal transduction|negative regulation of small GTPase mediated signal transduction|activation of GTPase activity",null,null,"R-HSA-162582,R-HSA-194315,R-HSA-9012999,R-HSA-9013149,R-HSA-9716542","Signal Transduction|Signaling by Rho GTPases|RHO GTPase cycle|RAC1 GTPase cycle|Signaling by Rho GTPases, Miro GTPases and RHOBTB3"]
["ARHGAP26",0.351871569484563,0.502032363674025,0.426329582093281,0.337465314369858,0.413530184338375,0.468846759708901,0.343820368164926,0.487258312717225,0.165010283247861,0.112202524861334,0.127446942574806,0.165046151259316,0.219316175913311,0.183599888336946,0.2122628700177,0.180339296152033,0.089147464772059,0.0571954975155279,0.043946920120697,0.0868780555008575,0.09873676846293,0.076836989550953,0.0399011482999704,0.0650373574894063,0.124927318649014,0.0722900066855656,0.0690202003746969,0.0826999970476391,23092,"Rho GTPase activating protein 26","protein_coding",null,null,"GO:0005096,GO:0005515,GO:0005543,GO:0005575,GO:0005829,GO:0005856,GO:0005925,GO:0007165,GO:0007399,GO:0030036,GO:0051056","GTPase activator activity|protein binding|phospholipid binding|cellular_component|cytosol|cytoskeleton|focal adhesion|signal transduction|nervous system development|actin cytoskeleton organization|regulation of small GTPase mediated signal transduction",null,null,"R-HSA-162582,R-HSA-194315,R-HSA-8980692,R-HSA-9012999,R-HSA-9013026,R-HSA-9013106,R-HSA-9013148,R-HSA-9013149,R-HSA-9013404,R-HSA-9013405,R-HSA-9013406,R-HSA-9013409,R-HSA-9013423,R-HSA-9716542","Signal Transduction|Signaling by Rho GTPases|RHOA GTPase cycle|RHO GTPase cycle|RHOB GTPase cycle|RHOC GTPase cycle|CDC42 GTPase cycle|RAC1 GTPase cycle|RAC2 GTPase cycle|RHOD GTPase cycle|RHOQ GTPase cycle|RHOJ GTPase cycle|RAC3 GTPase cycle|Signaling by Rho GTPases, Miro GTPases and RHOBTB3"]
["ARHGAP26-IT1",0,0,0,0,0,0,0,0,0,0,0,0,0,0.0662356985479287,0,0,0,0,0,0,0,0,0,0,0,0,0,0,100874372,"ARHGAP26 intronic transcript 1","non_coding"]
["ARHGAP27",0.321943177438345,0.397260163616359,0.289998327688128,0.429763664695969,0.289082078725979,0.486164931928405,0.243543305832312,0.430883028183315,0.218804861418804,0.209508475988097,0.225030973350729,0.275754052562247,0.17790675145874,0.269603666458806,0.157794713642818,0.193875658023871,0.092022094580802,0.124788691685471,0.172898787557487,0.184078986883829,0.254590952416615,0.190227937503894,0.150324428282737,0.195518443488223,0.189783857233123,0.169487309997572,0.176819148577733,0.249493162799426,201176,"Rho GTPase activating protein 27","protein_coding",null,null,"GO:0005096,GO:0005737,GO:0005829,GO:0006898,GO:0007165,GO:0016020,GO:0017124,GO:0043087,GO:0043547,GO:0051056","GTPase activator activity|cytoplasm|cytosol|receptor-mediated endocytosis|signal transduction|membrane|SH3 domain binding|regulation of GTPase activity|positive regulation of GTPase activity|regulation of small GTPase mediated signal transduction","WP5323","Fatty Acids and Lipoproteins Transport in Hepatocytes","R-HSA-162582,R-HSA-194315,R-HSA-9012999,R-HSA-9013148,R-HSA-9013149,R-HSA-9716542","Signal Transduction|Signaling by Rho GTPases|RHO GTPase cycle|CDC42 GTPase cycle|RAC1 GTPase cycle|Signaling by Rho GTPases, Miro GTPases and RHOBTB3"]
["ARHGAP28",0.795771477343037,1.02162264330342,0.657283595889519,0.608884751694383,1.05803826847488,0.865689801776676,1.05484358757762,0.741954093867814,1.5658846325008,1.04703542282808,1.07144695083034,1.24685510273692,1.77820653660002,1.14422463076312,1.9168845499334,2.13572317067625,0.514238179594845,0.611571020923476,0.723412102428805,0.62305671371885,0.435057754800137,0.611741516915671,1.19772052626697,0.904897265185463,0.607876673282044,0.425579135079736,0.593319866056957,0.564154001214696,79822,"Rho GTPase activating protein 28","protein_coding",null,null,"GO:0005096,GO:0005654,GO:0005737,GO:0005829,GO:0007165,GO:0030054,GO:0030833,GO:0051056,GO:0051497,GO:1904425","GTPase activator activity|nucleoplasm|cytoplasm|cytosol|signal transduction|cell junction|regulation of actin filament polymerization|regulation of small GTPase mediated signal transduction|negative regulation of stress fiber assembly|negative regulation of GTP binding"]
["ARHGAP28-AS1",0,0.0665969689872014,0.0657336615458438,0.0671495565869682,0,0,0,0.0686576120000982,0,0.067434520375182,0,0.0704420577066866,0.133169463248366,0,0.2604584870412,0.132771879205957,0,0,0.0647104130296704,0,0.132169714384026,0.266211699779589,0.0691213475057394,0.0684038552147392,0,0,0.0677533360907631,0.0658232759934105,101927168,"ARHGAP28 antisense RNA 1","non_coding"]
["ARHGAP29",13.5939568725222,13.8981229795758,11.1929957198111,8.98694275037699,14.5845606263669,12.2861986773843,10.6937036485653,10.4283225903881,5.22461348212917,3.75126989200555,2.73890835403201,3.78284043328139,6.76927867544105,4.2138040161191,6.21886791221753,5.81192974665836,9.30533507816313,7.18316962266516,8.21053408886363,9.80347283384226,9.57248971009059,8.7983676404686,12.8527276365489,10.9313320033759,9.6129810208374,7.45183750466394,10.2484016102863,6.89314581042951,9411,"Rho GTPase activating protein 29","protein_coding","hsa04520","Adherens junction","GO:0005096,GO:0005737,GO:0005829,GO:0007266,GO:0030165,GO:0032991,GO:0046872,GO:0051056,GO:0090630","GTPase activator activity|cytoplasm|cytosol|Rho protein signal transduction|PDZ domain binding|protein-containing complex|metal ion binding|regulation of small GTPase mediated signal transduction|activation of GTPase activity","WP3655","Hypothetical craniofacial development pathway","R-HSA-162582,R-HSA-194315,R-HSA-8980692,R-HSA-9012999,R-HSA-9013148,R-HSA-9013149,R-HSA-9716542","Signal Transduction|Signaling by Rho GTPases|RHOA GTPase cycle|RHO GTPase cycle|CDC42 GTPase cycle|RAC1 GTPase cycle|Signaling by Rho GTPases, Miro GTPases and RHOBTB3"]
["ARHGAP29-AS1",0.158511123832283,0.124163840484612,0.113800406792441,0.0536546093794177,0.118445598292979,0.113826488281421,0.234883239474802,0.10971918624713,0,0.0179607681386683,0.0350754230591772,0.00938090356868708,0.00886721607585976,0.00888946767090845,0.0260143161996356,0,0.00896463787337896,0.0258820165033814,0.0258528284501104,0.0358653313648063,0.0176012936831027,0.0177259606390767,0.0736401765194318,0.0182189444881872,0.0184884245686681,0.0265789550264055,0.0992512550482123,0.0876581157297234,107985092,null,"non_coding"]
["ARHGAP30",0.00609042368622754,5.79300340263726E-3,5.71790774856527E-3,0.00584107078309597,0,0,0,0,0.00612614062969232,0,0.0114553827456034,0,0,0,0,0,0,0,0.00562889946146026,0,0,0.00578917218793164,0,0.00595017719332909,0,0.00578699796515577,0.00589359114210207,0,257106,"Rho GTPase activating protein 30","protein_coding",null,null,"GO:0005096,GO:0005515,GO:0005829,GO:0007264,GO:0031410,GO:0043231,GO:0051056","GTPase activator activity|protein binding|cytosol|small GTPase mediated signal transduction|cytoplasmic vesicle|intracellular membrane-bounded organelle|regulation of small GTPase mediated signal transduction",null,null,"R-HSA-162582,R-HSA-194315,R-HSA-8980692,R-HSA-9012999,R-HSA-9013148,R-HSA-9013149,R-HSA-9013420,R-HSA-9716542","Signal Transduction|Signaling by Rho GTPases|RHOA GTPase cycle|RHO GTPase cycle|CDC42 GTPase cycle|RAC1 GTPase cycle|RHOU GTPase cycle|Signaling by Rho GTPases, Miro GTPases and RHOBTB3"]
["ARHGAP31",4.02579791408162,4.16739335345078,3.50497952591055,3.05797980704317,4.1495850582906,4.0469981390298,3.0818733113914,2.92702276624395,3.58216771049426,3.87459773994856,3.26558587399219,3.37235450502711,3.43583164672814,3.22029074791091,3.68796999567924,3.94484728966175,3.49839152310074,3.21819010317261,2.4327838822547,3.72515411100175,3.42627595404308,3.27883416156301,2.73448785776614,3.28878401430804,3.64160703027833,2.86347504483163,2.72753843316985,2.89514587708917,57514,"Rho GTPase activating protein 31","protein_coding",null,null,"GO:0005096,GO:0005515,GO:0005829,GO:0005925,GO:0007264,GO:0017124,GO:0030027,GO:0051056","GTPase activator activity|protein binding|cytosol|focal adhesion|small GTPase mediated signal transduction|SH3 domain binding|lamellipodium|regulation of small GTPase mediated signal transduction","WP5269","Genetic causes of porto-sinusoidal vascular disease","R-HSA-162582,R-HSA-194315,R-HSA-8980692,R-HSA-9012999,R-HSA-9013148,R-HSA-9013149,R-HSA-9013420,R-HSA-9716542","Signal Transduction|Signaling by Rho GTPases|RHOA GTPase cycle|RHO GTPase cycle|CDC42 GTPase cycle|RAC1 GTPase cycle|RHOU GTPase cycle|Signaling by Rho GTPases, Miro GTPases and RHOBTB3"]
["ARHGAP31-AS1",0.345592503015937,0.575252664809319,0.24334095860721,0.0828608310448166,0.168849223207595,0.121698364505025,0.201521677742656,0.29652606464786,0.391071611928147,0.29124364168448,0.528140875333757,0.391156618515495,0.410819257617156,0.164740070747412,0.361573981409358,0.327674189065986,0.498399386383434,0.519617428550525,0.23955297131176,0.41541135006272,0.122320528937139,0.287436110138618,0.938233675278225,0.464247318644904,0.256971324173171,0.492562557572682,0.79425585497425,0.324896939198244,100874246,"ARHGAP31 antisense RNA 1","non_coding"]
["ARHGAP32",1.51328912868537,1.67037852189438,1.19650338071775,1.01246792527934,1.42969317698314,1.27216516837954,1.18718189355727,0.980100063195506,1.40305542452368,1.3608407715352,1.0437771867217,1.32461068382106,1.46775434206788,1.02177848660132,1.63506494936183,1.55471412198786,0.862541533548995,0.826373931489778,0.660353600614,1.0228936169514,0.98694297370709,0.839406260566272,1.10956462826575,0.964712847500253,1.09240076874331,0.673179830750067,0.825414311507044,0.728314871966401,9743,"Rho GTPase activating protein 32","protein_coding",null,null,"GO:0000139,GO:0001650,GO:0005096,GO:0005515,GO:0005654,GO:0005789,GO:0005794,GO:0005829,GO:0005938,GO:0007264,GO:0010008,GO:0014069,GO:0015629,GO:0043197,GO:0051056,GO:1901981","Golgi membrane|fibrillar center|GTPase activator activity|protein binding|nucleoplasm|endoplasmic reticulum membrane|Golgi apparatus|cytosol|cell cortex|small GTPase mediated signal transduction|endosome membrane|postsynaptic density|actin cytoskeleton|dendritic spine|regulation of small GTPase mediated signal transduction|phosphatidylinositol phosphate binding","WP4549","Fragile X syndrome","R-HSA-162582,R-HSA-194315,R-HSA-8980692,R-HSA-9012999,R-HSA-9013026,R-HSA-9013106,R-HSA-9013148,R-HSA-9013149,R-HSA-9013404,R-HSA-9013405,R-HSA-9013406,R-HSA-9013408,R-HSA-9013409,R-HSA-9013423,R-HSA-9035034,R-HSA-9716542","Signal Transduction|Signaling by Rho GTPases|RHOA GTPase cycle|RHO GTPase cycle|RHOB GTPase cycle|RHOC GTPase cycle|CDC42 GTPase cycle|RAC1 GTPase cycle|RAC2 GTPase cycle|RHOD GTPase cycle|RHOQ GTPase cycle|RHOG GTPase cycle|RHOJ GTPase cycle|RAC3 GTPase cycle|RHOF GTPase cycle|Signaling by Rho GTPases, Miro GTPases and RHOBTB3"]
["ARHGAP33",1.59543091031175,2.16788499648076,1.26210890999027,2.10436586907971,1.52878961339293,1.59976319566021,0.774896769445535,1.42810391140072,1.65918679110587,2.98763530332321,1.91456743801128,1.8072355088764,1.08374332103992,1.13434091706386,0.77240797022196,0.912021797082198,1.43363033583953,1.48691900448507,1.00682280633868,1.51934111661804,1.56054209918313,1.48346832128537,0.648322183182952,1.1171257294743,1.52812869989824,1.41684087927756,0.867258237263823,1.62336725166035,115703,"Rho GTPase activating protein 33","protein_coding",null,null,"GO:0001650,GO:0005096,GO:0005515,GO:0005654,GO:0005794,GO:0005829,GO:0005886,GO:0005938,GO:0007264,GO:0009636,GO:0015031,GO:0015629,GO:0019901,GO:0032991,GO:0035091,GO:0043197,GO:0061001","fibrillar center|GTPase activator activity|protein binding|nucleoplasm|Golgi apparatus|cytosol|plasma membrane|cell cortex|small GTPase mediated signal transduction|response to toxic substance|protein transport|actin cytoskeleton|protein kinase binding|protein-containing complex|phosphatidylinositol binding|dendritic spine|regulation of dendritic spine morphogenesis","WP481","Insulin signaling","R-HSA-162582,R-HSA-194315,R-HSA-9012999,R-HSA-9013148,R-HSA-9013149,R-HSA-9013406,R-HSA-9716542","Signal Transduction|Signaling by Rho GTPases|RHO GTPase cycle|CDC42 GTPase cycle|RAC1 GTPase cycle|RHOQ GTPase cycle|Signaling by Rho GTPases, Miro GTPases and RHOBTB3"]
["ARHGAP35",24.3845592816265,28.0619495434802,26.2033222256228,22.4871547635471,25.8373491512318,26.3669935642305,25.0741919746133,23.3571300153391,25.8532991853173,28.3151481738544,24.5033681232394,24.9608246856203,25.5659310635013,25.2325763421704,28.2076500908396,28.5381666201922,19.9548083606258,23.0774220650056,19.6271794794596,24.4470420425575,21.6419846501683,22.0506221219123,20.0616943684077,20.7556313177894,21.8449900840977,18.7346600845188,19.006628923296,18.8913758735432,2909,"Rho GTPase activating protein 35","protein_coding","hsa04510,hsa04810,hsa04611,hsa04670","Focal adhesion|Regulation of actin cytoskeleton|Platelet activation|Leukocyte transendothelial migration","GO:0001843,GO:0003677,GO:0003924,GO:0005096,GO:0005525,GO:0005543,GO:0005634,GO:0005829,GO:0005886,GO:0007266,GO:0007411,GO:0007413,GO:0008064,GO:0008360,GO:0008361,GO:0010976,GO:0015629,GO:0016477,GO:0021955,GO:0030879,GO:0030900,GO:0030950,GO:0031668,GO:0032794,GO:0032956,GO:0035024,GO:0036064,GO:0043010,GO:0043116,GO:0044319,GO:0044877,GO:0045724,GO:0050770,GO:0051056,GO:0097485","neural tube closure|DNA binding|GTPase activity|GTPase activator activity|GTP binding|phospholipid binding|nucleus|cytosol|plasma membrane|Rho protein signal transduction|axon guidance|axonal fasciculation|regulation of actin polymerization or depolymerization|regulation of cell shape|regulation of cell size|positive regulation of neuron projection development|actin cytoskeleton|cell migration|central nervous system neuron axonogenesis|mammary gland development|forebrain development|establishment or maintenance of actin cytoskeleton polarity|cellular response to extracellular stimulus|GTPase activating protein binding|regulation of actin cytoskeleton organization|negative regulation of Rho protein signal transduction|ciliary basal body|camera-type eye development|negative regulation of vascular permeability|wound healing, spreading of cells|protein-containing complex binding|positive regulation of cilium assembly|regulation of axonogenesis|regulation of small GTPase mediated signal transduction|neuron projection guidance","WP306,WP51","Focal adhesion|Regulation of actin cytoskeleton","R-HSA-1266738,R-HSA-162582,R-HSA-194315,R-HSA-373755,R-HSA-400685,R-HSA-416550,R-HSA-422475,R-HSA-8848021,R-HSA-8849471,R-HSA-8980692,R-HSA-9006927,R-HSA-9012999,R-HSA-9013026,R-HSA-9013106,R-HSA-9013148,R-HSA-9013149,R-HSA-9013404,R-HSA-9013405,R-HSA-9013406,R-HSA-9013408,R-HSA-9013409,R-HSA-9013423,R-HSA-9675108,R-HSA-9696264,R-HSA-9696270,R-HSA-9696273,R-HSA-9716542","Developmental Biology|Signal Transduction|Signaling by Rho GTPases|Semaphorin interactions|Sema4D in semaphorin signaling|Sema4D mediated inhibition of cell attachment and migration|Axon guidance|Signaling by PTK6|PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases|RHOA GTPase cycle|Signaling by Non-Receptor Tyrosine Kinases|RHO GTPase cycle|RHOB GTPase cycle|RHOC GTPase cycle|CDC42 GTPase cycle|RAC1 GTPase cycle|RAC2 GTPase cycle|RHOD GTPase cycle|RHOQ GTPase cycle|RHOG GTPase cycle|RHOJ GTPase cycle|RAC3 GTPase cycle|Nervous system development|RND3 GTPase cycle|RND2 GTPase cycle|RND1 GTPase cycle|Signaling by Rho GTPases, Miro GTPases and RHOBTB3"]
["ARHGAP39",0.684428468585581,0.813756286024899,0.684332730108788,0.810662318603243,0.692202502960475,0.56880119177568,0.510852464284036,0.644302485596961,0.695326683033855,1.00197235809461,1.06204791992975,0.833196206237399,0.621595561760101,0.662306532998484,0.623784354199853,0.622984468129009,0.602103410032342,0.620612005560916,0.499725076119697,0.621962079230633,0.587859076227542,0.686356081998061,0.361489642059024,0.458037494388906,0.580167326278492,0.747879673552021,0.404008403730245,0.637007531925566,80728,"Rho GTPase activating protein 39","protein_coding",null,null,"GO:0005096,GO:0005634,GO:0005737,GO:0005829,GO:0005856,GO:0007165,GO:0051056,GO:0098978,GO:0099173","GTPase activator activity|nucleus|cytoplasm|cytosol|cytoskeleton|signal transduction|regulation of small GTPase mediated signal transduction|glutamatergic synapse|postsynapse organization",null,null,"R-HSA-1266738,R-HSA-162582,R-HSA-194315,R-HSA-376176,R-HSA-422475,R-HSA-428543,R-HSA-8980692,R-HSA-9012999,R-HSA-9013026,R-HSA-9013106,R-HSA-9013148,R-HSA-9013149,R-HSA-9013404,R-HSA-9013405,R-HSA-9013408,R-HSA-9013423,R-HSA-9035034,R-HSA-9675108,R-HSA-9716542","Developmental Biology|Signal Transduction|Signaling by Rho GTPases|Signaling by ROBO receptors|Axon guidance|Inactivation of CDC42 and RAC1|RHOA GTPase cycle|RHO GTPase cycle|RHOB GTPase cycle|RHOC GTPase cycle|CDC42 GTPase cycle|RAC1 GTPase cycle|RAC2 GTPase cycle|RHOD GTPase cycle|RHOG GTPase cycle|RAC3 GTPase cycle|RHOF GTPase cycle|Nervous system development|Signaling by Rho GTPases, Miro GTPases and RHOBTB3"]
["ARHGAP4",0.167777273248401,0.296370328791591,0.195018954378748,0.283504870652449,0.265434582066711,0.285093026985099,0.290707264347674,0.274203118465122,0.377703623612879,0.792565472874286,0.540976545688638,0.626963542659098,0.547044683053456,0.77692472013421,0.705858710990804,0.560561772166233,0.514648329033753,0.480499815375707,0.502109843840181,0.376455762878415,0.497693011632795,0.394899098220759,0.283942464857601,0.366854700684856,0.285151344903484,0.341611258067598,0.425215439158835,0.503233966879082,393,"Rho GTPase activating protein 4","protein_coding",null,null,"GO:0005096,GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0005874,GO:0007010,GO:0007266,GO:0007399,GO:0010764,GO:0030336,GO:0030426,GO:0030517,GO:0051056","GTPase activator activity|protein binding|nucleoplasm|cytoplasm|cytosol|microtubule|cytoskeleton organization|Rho protein signal transduction|nervous system development|negative regulation of fibroblast migration|negative regulation of cell migration|growth cone|negative regulation of axon extension|regulation of small GTPase mediated signal transduction","WP5205","Clock-controlled autophagy in bone metabolism","R-HSA-162582,R-HSA-194315,R-HSA-8980692,R-HSA-9012999,R-HSA-9013148,R-HSA-9013149,R-HSA-9716542","Signal Transduction|Signaling by Rho GTPases|RHOA GTPase cycle|RHO GTPase cycle|CDC42 GTPase cycle|RAC1 GTPase cycle|Signaling by Rho GTPases, Miro GTPases and RHOBTB3"]
["ARHGAP40",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.00901653769028673,0,0,0,343578,"Rho GTPase activating protein 40","protein_coding",null,null,"GO:0005096,GO:0005737,GO:0005829,GO:0007165,GO:0030833,GO:0051056","GTPase activator activity|cytoplasm|cytosol|signal transduction|regulation of actin filament polymerization|regulation of small GTPase mediated signal transduction"]
["ARHGAP42",1.34135977775636,1.40703820638292,1.20919451753521,0.793625969168641,1.61938081541398,1.36196116526766,1.3780770072484,1.26952559175293,1.64457908432566,1.14407188017277,1.18406761025478,1.28014110811739,1.70294379836813,1.23004469394503,1.81222622007582,1.57763846235896,0.846925248754553,0.755370574463281,0.682561890860907,0.951901499301999,0.921714155661667,0.873266861764597,1.04971130396775,1.00186980052714,0.893186348751773,0.767256216928696,0.850271380261,0.608558402865303,143872,"Rho GTPase activating protein 42","protein_coding",null,null,"GO:0003085,GO:0005096,GO:0005575,GO:0005737,GO:0007165,GO:0035024,GO:0090630,GO:1904694","negative regulation of systemic arterial blood pressure|GTPase activator activity|cellular_component|cytoplasm|signal transduction|negative regulation of Rho protein signal transduction|activation of GTPase activity|negative regulation of vascular associated smooth muscle contraction",null,null,"R-HSA-162582,R-HSA-194315,R-HSA-8980692,R-HSA-9012999,R-HSA-9013148,R-HSA-9013149,R-HSA-9013404,R-HSA-9013423,R-HSA-9716542","Signal Transduction|Signaling by Rho GTPases|RHOA GTPase cycle|RHO GTPase cycle|CDC42 GTPase cycle|RAC1 GTPase cycle|RAC2 GTPase cycle|RAC3 GTPase cycle|Signaling by Rho GTPases, Miro GTPases and RHOBTB3"]
["ARHGAP42-AS1",0.0144459888720488,0.0549621287461362,0.189873759770685,0.0277090881950512,0.127044110066164,0.0135655197304637,0.107823817287388,0.0849941499036586,0.029061413105057,0.0278266777539604,0.190198643207012,0.130804785612898,0.0824280439720597,0.0550899271952762,0.0806081330473167,0.0958789427813656,0.0138889432432682,0.0267327294431138,0.0534051640223432,0.138915692625475,0.0272697427855573,0.0823886691440047,0.0142613712699408,0.042340006845136,0.0859325328424754,0.0137262877780168,0.139791181109023,0.067904504977125,100128386,"ARHGAP42 antisense RNA 1","non_coding"]
["ARHGAP44",0.056119809650055,0.0533792499515736,0.0643955717433839,0.0837233657191207,0.048744813916974,0.0292774228742139,0.00581769728944794,0.0183436367939193,0.0752652281110845,0.144134852710312,0.0469132769206946,0.25721209366182,0.160108324134486,0.101061917099731,0.0927841938569161,0.0886835071032162,0.0419656203200486,0.0692342444702989,0.0518671249474458,0.035977332746584,0.0588541985170599,0.0829794738498719,0.104649368361106,0.0609194639317015,0.0556384824025188,0.0592487924908153,0.0543061090803826,0.0996561048755197,9912,"Rho GTPase activating protein 44","protein_coding",null,null,"GO:0005096,GO:0005515,GO:0005543,GO:0005622,GO:0005829,GO:0006887,GO:0007165,GO:0014069,GO:0030425,GO:0031256,GO:0031267,GO:0032956,GO:0035021,GO:0043087,GO:0043197,GO:0048786,GO:0050804,GO:0051056,GO:0051490,GO:0055037,GO:0061001,GO:0098886,GO:0098887,GO:0098978,GO:0099152","GTPase activator activity|protein binding|phospholipid binding|intracellular anatomical structure|cytosol|exocytosis|signal transduction|postsynaptic density|dendrite|leading edge membrane|small GTPase binding|regulation of actin cytoskeleton organization|negative regulation of Rac protein signal transduction|regulation of GTPase activity|dendritic spine|presynaptic active zone|modulation of chemical synaptic transmission|regulation of small GTPase mediated signal transduction|negative regulation of filopodium assembly|recycling endosome|regulation of dendritic spine morphogenesis|modification of dendritic spine|neurotransmitter receptor transport, endosome to postsynaptic membrane|glutamatergic synapse|regulation of neurotransmitter receptor transport, endosome to postsynaptic membrane",null,null,"R-HSA-162582,R-HSA-194315,R-HSA-8980692,R-HSA-9012999,R-HSA-9013148,R-HSA-9013149,R-HSA-9716542","Signal Transduction|Signaling by Rho GTPases|RHOA GTPase cycle|RHO GTPase cycle|CDC42 GTPase cycle|RAC1 GTPase cycle|Signaling by Rho GTPases, Miro GTPases and RHOBTB3"]
["ARHGAP44-AS1",0,0,0,0,0.014134949729211,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.0208653084871857,0,0,0,0,0,0,0,0,100128006,"ARHGAP44 and MYOCD antisense RNA 1","non_coding"]
["ARHGAP45",0.163838276367226,0.288757504966852,0.235249893483695,0.194102311407092,0.155387165011208,0.194578150184653,0.184330733048556,0.245714228144792,0.198728322400383,0.380569862038701,0.285501967645563,0.266644721476419,0.279539224560948,0.188358507776269,0.286811633924525,0.379221076155379,0.24091382566693,0.365608544650494,0.240495081674445,0.32436839061029,0.195572901468318,0.361853273542912,0.176016016306624,0.338962257159916,0.257981937174925,0.270143354778868,0.237814936385794,0.312584077004817,23526,"Rho GTPase activating protein 45","protein_coding",null,null,"GO:0005096,GO:0005515,GO:0005576,GO:0005829,GO:0005886,GO:0007165,GO:0016020,GO:0032587,GO:0034774,GO:0035578,GO:0046872,GO:0051056,GO:0090630","GTPase activator activity|protein binding|extracellular region|cytosol|plasma membrane|signal transduction|membrane|ruffle membrane|secretory granule lumen|azurophil granule lumen|metal ion binding|regulation of small GTPase mediated signal transduction|activation of GTPase activity",null,null,"R-HSA-162582,R-HSA-168249,R-HSA-168256,R-HSA-194315,R-HSA-6798695,R-HSA-8980692,R-HSA-9012999,R-HSA-9013148,R-HSA-9013149,R-HSA-9716542","Signal Transduction|Innate Immune System|Immune System|Signaling by Rho GTPases|Neutrophil degranulation|RHOA GTPase cycle|RHO GTPase cycle|CDC42 GTPase cycle|RAC1 GTPase cycle|Signaling by Rho GTPases, Miro GTPases and RHOBTB3"]
["ARHGAP5",4.07033957817101,3.66309919870945,2.81091929826347,2.01002630963975,4.57970575497798,3.61644249146608,2.9522611254557,2.42168231887388,4.23986924223573,2.41246690677965,1.80721947729451,2.60078213566281,5.42106057641957,2.4178939051491,3.77629353602611,4.48458106481699,2.80333825459081,2.16191027695736,2.48502079045846,3.82191711095382,3.53703906252206,2.66924335455042,5.35518580653903,4.06646642584928,3.1740202526403,1.92262095067644,3.71344845361051,1.97768481682561,394,"Rho GTPase activating protein 5","protein_coding","hsa04510,hsa04670","Focal adhesion|Leukocyte transendothelial migration","GO:0002053,GO:0003924,GO:0005096,GO:0005515,GO:0005525,GO:0005737,GO:0005783,GO:0005829,GO:0005886,GO:0007155,GO:0007266,GO:0008361,GO:0010631,GO:0010634,GO:0030879,GO:0042169,GO:0051056","positive regulation of mesenchymal cell proliferation|GTPase activity|GTPase activator activity|protein binding|GTP binding|cytoplasm|endoplasmic reticulum|cytosol|plasma membrane|cell adhesion|Rho protein signal transduction|regulation of cell size|epithelial cell migration|positive regulation of epithelial cell migration|mammary gland development|SH2 domain binding|regulation of small GTPase mediated signal transduction","WP306","Focal adhesion","R-HSA-162582,R-HSA-194315,R-HSA-8980692,R-HSA-9012999,R-HSA-9013026,R-HSA-9013106,R-HSA-9013148,R-HSA-9013149,R-HSA-9013405,R-HSA-9013406,R-HSA-9013408,R-HSA-9013409,R-HSA-9013423,R-HSA-9035034,R-HSA-9696264,R-HSA-9696270,R-HSA-9696273,R-HSA-9716542","Signal Transduction|Signaling by Rho GTPases|RHOA GTPase cycle|RHO GTPase cycle|RHOB GTPase cycle|RHOC GTPase cycle|CDC42 GTPase cycle|RAC1 GTPase cycle|RHOD GTPase cycle|RHOQ GTPase cycle|RHOG GTPase cycle|RHOJ GTPase cycle|RAC3 GTPase cycle|RHOF GTPase cycle|RND3 GTPase cycle|RND2 GTPase cycle|RND1 GTPase cycle|Signaling by Rho GTPases, Miro GTPases and RHOBTB3"]
["ARHGAP5-AS1",0.44190516779087,1.00077412412461,0.928532869377084,0.665991503854357,0.555185736261039,0.671858574379034,0.903119162829851,0.949200865356549,0.275164621039216,0.567481756162734,0.752013237009191,0.762159968629724,0.940554815565649,0.722232816016759,0.900218541276279,0.638465867219907,0.445096719767876,0.856699460654729,0.797387876403863,0.323767909369727,0.337646674724219,0.500056130050457,0.810192843714814,0.740107285929965,0.730191740819941,0.539857791437974,1.26250751950547,0.751752168449333,84837,"ARHGAP5 antisense RNA 1 (head to head)","non_coding"]
["ARHGAP6",0.219898323452037,0.260463134056454,0.206448416783583,0.171103726227067,0.300014688734566,0.222080315464304,0.181937132979424,0.199357526609489,0.438202452645361,0.515489526617425,0.339466876311185,0.442471967832827,0.363003108223575,0.628938389228693,0.725411162538174,0.664830100087398,0.111693013171353,0.122846293713037,0.22624242449884,0.19150993931166,0.148810444931376,0.177471051973271,0.22937605852297,0.154032384453075,0.26737358033102,0.220769919601608,0.260970792007287,0.202829303584435,395,"Rho GTPase activating protein 6","protein_coding",null,null,"GO:0005096,GO:0005737,GO:0005829,GO:0005884,GO:0007202,GO:0007266,GO:0015629,GO:0016004,GO:0017124,GO:0030041,GO:0043274,GO:0048041,GO:0051056,GO:0051497,GO:0051895","GTPase activator activity|cytoplasm|cytosol|actin filament|activation of phospholipase C activity|Rho protein signal transduction|actin cytoskeleton|phospholipase activator activity|SH3 domain binding|actin filament polymerization|phospholipase binding|focal adhesion assembly|regulation of small GTPase mediated signal transduction|negative regulation of stress fiber assembly|negative regulation of focal adhesion assembly",null,null,"R-HSA-162582,R-HSA-194315,R-HSA-8980692,R-HSA-9012999,R-HSA-9013423,R-HSA-9716542","Signal Transduction|Signaling by Rho GTPases|RHOA GTPase cycle|RHO GTPase cycle|RAC3 GTPase cycle|Signaling by Rho GTPases, Miro GTPases and RHOBTB3"]
["ARHGAP9",0.0428897617108084,0.0135984264439525,0.00671107390483953,0.00685562961707313,0.0558800929628954,0.0335630599536533,0.0133385867845576,0.0280383777459961,0.0143804287600202,0.00688472297651686,0,0.0215753319149358,0.020393891547582,0.0272600912613061,0.0332393653907657,0.0203330045721136,0.0206179539315342,0.00661406432522546,0.00660660541406076,0.00687395074089466,0.00674692920151817,0.027178866193355,0.00705693948281879,6.98368715398424E-3,0.00708698427844334,0.0339608233807736,0.00691727244628581,6.72022308604164E-3,64333,"Rho GTPase activating protein 9","protein_coding",null,null,"GO:0005096,GO:0005515,GO:0005547,GO:0005576,GO:0005737,GO:0005829,GO:0007165,GO:0034774,GO:0043087,GO:0051056","GTPase activator activity|protein binding|phosphatidylinositol-3,4,5-trisphosphate binding|extracellular region|cytoplasm|cytosol|signal transduction|secretory granule lumen|regulation of GTPase activity|regulation of small GTPase mediated signal transduction",null,null,"R-HSA-162582,R-HSA-168249,R-HSA-168256,R-HSA-194315,R-HSA-6798695,R-HSA-8980692,R-HSA-9012999,R-HSA-9013148,R-HSA-9013149,R-HSA-9716542","Signal Transduction|Innate Immune System|Immune System|Signaling by Rho GTPases|Neutrophil degranulation|RHOA GTPase cycle|RHO GTPase cycle|CDC42 GTPase cycle|RAC1 GTPase cycle|Signaling by Rho GTPases, Miro GTPases and RHOBTB3"]
["ARHGDIA",222.169525652455,259.449646350168,249.997833872122,289.679478942893,196.899589538339,250.661954660913,226.295317307455,245.762949437757,201.894737516932,325.417748837907,308.940707650713,249.654372190054,184.164645528708,231.328063761349,203.064240618635,194.80763571616,212.859209166067,261.235882692034,283.145869382285,242.738224672779,240.267680058855,279.482398597796,205.648436469109,208.632051229677,208.205735178624,296.317706402778,210.600919815342,292.040067230695,396,"Rho GDP dissociation inhibitor alpha","protein_coding","hsa04962,hsa04722","Vasopressin-regulated water reabsorption|Neurotrophin signaling pathway","GO:0001772,GO:0005094,GO:0005096,GO:0005515,GO:0005634,GO:0005829,GO:0005856,GO:0007266,GO:0016020,GO:0032880,GO:0035023,GO:0043066,GO:0070062,GO:0071526,GO:0098685,GO:0098693","immunological synapse|Rho GDP-dissociation inhibitor activity|GTPase activator activity|protein binding|nucleus|cytosol|cytoskeleton|Rho protein signal transduction|membrane|regulation of protein localization|regulation of Rho protein signal transduction|negative regulation of apoptotic process|extracellular exosome|semaphorin-plexin signaling pathway|Schaffer collateral - CA1 synapse|regulation of synaptic vesicle cycle","WP5085,WP4352,WP4758","Vasopressin-regulated water reabsorption|Ciliary landscape|Nephrotic syndrome","R-HSA-162582,R-HSA-193634,R-HSA-193697,R-HSA-193704,R-HSA-194315,R-HSA-209563,R-HSA-73887,R-HSA-8980692,R-HSA-9012999,R-HSA-9013106,R-HSA-9013148,R-HSA-9013149,R-HSA-9013404,R-HSA-9013407,R-HSA-9013408,R-HSA-9716542","Signal Transduction|Axonal growth inhibition (RHOA activation)|p75NTR regulates axonogenesis|p75 NTR receptor-mediated signalling|Signaling by Rho GTPases|Axonal growth stimulation|Death Receptor Signaling|RHOA GTPase cycle|RHO GTPase cycle|RHOC GTPase cycle|CDC42 GTPase cycle|RAC1 GTPase cycle|RAC2 GTPase cycle|RHOH GTPase cycle|RHOG GTPase cycle|Signaling by Rho GTPases, Miro GTPases and RHOBTB3"]
["ARHGDIB",0.172997880739599,0.179508749545432,0.324833204955249,0.361996442744216,0.16904624680527,0.103379707537524,0.146732236769448,0.231328885239537,0.363844144586592,0.287796684098282,0.384550649017811,0.395568731287549,0.209388391746994,0.254895372008248,0.131634868377736,0.0596466435172623,0.876996819913908,0.858551083812769,0.494200295541649,1.16450901679192,0.994550111591584,1.07634018639005,0.760778425143392,0.921895598284991,0.561318925148398,0.612685748392624,0.669627487384788,0.768834297192577,397,"Rho GDP dissociation inhibitor beta","protein_coding","hsa04962,hsa04722","Vasopressin-regulated water reabsorption|Neurotrophin signaling pathway","GO:0003924,GO:0005094,GO:0005096,GO:0005515,GO:0005737,GO:0005829,GO:0005856,GO:0007266,GO:0016020,GO:0031267,GO:0031410,GO:0035023,GO:0070062,GO:0071461,GO:1901164","GTPase activity|Rho GDP-dissociation inhibitor activity|GTPase activator activity|protein binding|cytoplasm|cytosol|cytoskeleton|Rho protein signal transduction|membrane|small GTPase binding|cytoplasmic vesicle|regulation of Rho protein signal transduction|extracellular exosome|cellular response to redox state|negative regulation of trophoblast cell migration","WP314,WP5085,WP524","Fas ligand pathway and stress induction of heat shock proteins|Vasopressin-regulated water reabsorption|G13 signaling pathway","R-HSA-162582,R-HSA-194315,R-HSA-8980692,R-HSA-9012999,R-HSA-9013148,R-HSA-9013149,R-HSA-9013407,R-HSA-9013408,R-HSA-9013423,R-HSA-9716542","Signal Transduction|Signaling by Rho GTPases|RHOA GTPase cycle|RHO GTPase cycle|CDC42 GTPase cycle|RAC1 GTPase cycle|RHOH GTPase cycle|RHOG GTPase cycle|RAC3 GTPase cycle|Signaling by Rho GTPases, Miro GTPases and RHOBTB3"]
["ARHGDIG",0,0,0,0.0268180283049614,0,0,0,0,0.0281268655881931,0.0538636729137864,0,0.0281329794782929,0.0265924498706541,0.0266591815732327,0.0260053209312401,0,0,0,0,0,0,0,0,0,0,0.0265697645163687,0.0270591643101076,0.184018390873694,398,"Rho GDP dissociation inhibitor gamma","protein_coding","hsa04962,hsa04722","Vasopressin-regulated water reabsorption|Neurotrophin signaling pathway","GO:0001835,GO:0005094,GO:0005096,GO:0005515,GO:0005829,GO:0005886,GO:0007162,GO:0007266,GO:0016020,GO:0031410,GO:0032880","blastocyst hatching|Rho GDP-dissociation inhibitor activity|GTPase activator activity|protein binding|cytosol|plasma membrane|negative regulation of cell adhesion|Rho protein signal transduction|membrane|cytoplasmic vesicle|regulation of protein localization","WP5085,WP2858,WP524","Vasopressin-regulated water reabsorption|Ectoderm differentiation|G13 signaling pathway","R-HSA-162582,R-HSA-194315,R-HSA-9012999,R-HSA-9013026,R-HSA-9013148,R-HSA-9013407,R-HSA-9013408,R-HSA-9716542","Signal Transduction|Signaling by Rho GTPases|RHO GTPase cycle|RHOB GTPase cycle|CDC42 GTPase cycle|RHOH GTPase cycle|RHOG GTPase cycle|Signaling by Rho GTPases, Miro GTPases and RHOBTB3"]
["ARHGEF1",16.040171243733,18.4138904095885,19.5221880650592,20.8875143899993,14.1232000739174,17.0741880051201,16.9393279812976,17.8879434218014,15.6088443483472,21.1608267879791,20.9795121515949,17.8672642371993,15.474131577861,18.3936713575639,18.2438329319798,16.8259128843125,14.8113980020154,19.1910507533539,18.8516495746051,17.904198620275,16.2503587758844,17.8172317277978,14.6015243886633,15.5351581161901,15.3978578882043,17.5341155520329,14.1845772022542,19.7228459823228,9138,"Rho guanine nucleotide exchange factor 1","protein_coding","hsa04810,hsa04611,hsa04928,hsa04270,hsa05200,hsa05205,hsa05163,hsa05130,hsa05135,hsa05417","Regulation of actin cytoskeleton|Platelet activation|Parathyroid hormone synthesis, secretion and action|Vascular smooth muscle contraction|Pathways in cancer|Proteoglycans in cancer|Human cytomegalovirus infection|Pathogenic Escherichia coli infection|Yersinia infection|Lipid and atherosclerosis","GO:0001664,GO:0003723,GO:0005085,GO:0005096,GO:0005515,GO:0005737,GO:0005829,GO:0005886,GO:0007186,GO:0007266,GO:0051056","G protein-coupled receptor binding|RNA binding|guanyl-nucleotide exchange factor activity|GTPase activator activity|protein binding|cytoplasm|cytosol|plasma membrane|G protein-coupled receptor signaling pathway|Rho protein signal transduction|regulation of small GTPase mediated signal transduction","WP35,WP51,WP437,WP524","G protein signaling pathways|Regulation of actin cytoskeleton|EGF/EGFR signaling pathway|G13 signaling pathway","R-HSA-162582,R-HSA-193648,R-HSA-193704,R-HSA-194315,R-HSA-204998,R-HSA-372790,R-HSA-388396,R-HSA-416482,R-HSA-73887,R-HSA-8980692,R-HSA-9012999,R-HSA-9013026,R-HSA-9013106,R-HSA-9716542","Signal Transduction|NRAGE signals death through JNK|p75 NTR receptor-mediated signalling|Signaling by Rho GTPases|Cell death signalling via NRAGE, NRIF and NADE|Signaling by GPCR|GPCR downstream signalling|G alpha (12/13) signalling events|Death Receptor Signaling|RHOA GTPase cycle|RHO GTPase cycle|RHOB GTPase cycle|RHOC GTPase cycle|Signaling by Rho GTPases, Miro GTPases and RHOBTB3"]
["ARHGEF10",8.21397517899928,8.61748535531218,7.49347709022242,6.77631834292751,8.37327416160201,7.82035669144491,7.01743701398348,6.79526155451704,7.85212447130397,8.24883176147084,6.07181665847121,6.70728656295448,7.9573085005151,6.93676239361787,8.18924893005373,8.05822759393786,6.67936218304433,7.12965806354593,5.89417164534888,7.98724574344985,7.078440390631,7.01191877767006,6.3262329870822,6.9028944103043,7.71331812071016,6.41372513990574,5.84050282306302,6.85263114978228,9639,"Rho guanine nucleotide exchange factor 10","protein_coding",null,null,"GO:0005085,GO:0005515,GO:0005813,GO:0005829,GO:0019894,GO:0022011,GO:0030036,GO:0051056,GO:0051298,GO:0051496,GO:0090307,GO:0090630","guanyl-nucleotide exchange factor activity|protein binding|centrosome|cytosol|kinesin binding|myelination in peripheral nervous system|actin cytoskeleton organization|regulation of small GTPase mediated signal transduction|centrosome duplication|positive regulation of stress fiber assembly|mitotic spindle assembly|activation of GTPase activity",null,null,"R-HSA-162582,R-HSA-193648,R-HSA-193704,R-HSA-194315,R-HSA-204998,R-HSA-372790,R-HSA-388396,R-HSA-416482,R-HSA-73887,R-HSA-8980692,R-HSA-9012999,R-HSA-9013026,R-HSA-9013106,R-HSA-9013148,R-HSA-9013149,R-HSA-9716542","Signal Transduction|NRAGE signals death through JNK|p75 NTR receptor-mediated signalling|Signaling by Rho GTPases|Cell death signalling via NRAGE, NRIF and NADE|Signaling by GPCR|GPCR downstream signalling|G alpha (12/13) signalling events|Death Receptor Signaling|RHOA GTPase cycle|RHO GTPase cycle|RHOB GTPase cycle|RHOC GTPase cycle|CDC42 GTPase cycle|RAC1 GTPase cycle|Signaling by Rho GTPases, Miro GTPases and RHOBTB3"]
["ARHGEF10L",2.60856814474052,3.00338316817098,2.99007906829159,2.63849323870669,2.8394484876706,3.02209617034827,2.82713575749985,2.90298011535466,2.40114243975057,3.17553838240258,2.8668297317543,2.59697125877464,2.37688086648541,2.77902244246304,2.5782811130001,2.97373452194777,1.84599012064781,2.23119174901407,1.93712554634279,1.85217276188649,2.03839102660904,2.03841267079738,1.77271717379409,1.90841137188505,1.90957423747004,2.06646814409135,1.64077126440571,1.87918898038349,55160,"Rho guanine nucleotide exchange factor 10 like","protein_coding",null,null,"GO:0005085,GO:0005096,GO:0005829,GO:0030036,GO:0032933,GO:0051056,GO:0051496","guanyl-nucleotide exchange factor activity|GTPase activator activity|cytosol|actin cytoskeleton organization|SREBP signaling pathway|regulation of small GTPase mediated signal transduction|positive regulation of stress fiber assembly",null,null,"R-HSA-162582,R-HSA-193648,R-HSA-193704,R-HSA-194315,R-HSA-204998,R-HSA-372790,R-HSA-388396,R-HSA-416482,R-HSA-73887,R-HSA-8980692,R-HSA-9012999,R-HSA-9013026,R-HSA-9013106,R-HSA-9716542","Signal Transduction|NRAGE signals death through JNK|p75 NTR receptor-mediated signalling|Signaling by Rho GTPases|Cell death signalling via NRAGE, NRIF and NADE|Signaling by GPCR|GPCR downstream signalling|G alpha (12/13) signalling events|Death Receptor Signaling|RHOA GTPase cycle|RHO GTPase cycle|RHOB GTPase cycle|RHOC GTPase cycle|Signaling by Rho GTPases, Miro GTPases and RHOBTB3"]
["ARHGEF11",5.93153585318797,7.05763595533217,6.2713603806435,5.92349324129237,7.02213404820456,6.88936589302803,6.15963726619451,5.67458103928978,6.5651918783966,8.215541562191,6.98853187581694,6.68977803682606,6.87907073545334,6.38441311230131,7.42578195005093,7.11968475906177,5.44335050749252,6.04169894011641,5.10406805631127,5.62898028539525,5.55647535969092,5.50062775269622,4.90541126622164,4.99855047475111,5.38692946593676,5.1363970035002,4.37487675629927,4.87798098309098,9826,"Rho guanine nucleotide exchange factor 11","protein_coding","hsa04928,hsa04270,hsa05200,hsa05163,hsa05130","Parathyroid hormone synthesis, secretion and action|Vascular smooth muscle contraction|Pathways in cancer|Human cytomegalovirus infection|Pathogenic Escherichia coli infection","GO:0001558,GO:0001664,GO:0005085,GO:0005096,GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0006941,GO:0007186,GO:0007266,GO:0030010,GO:0030036,GO:0045893,GO:0051056","regulation of cell growth|G protein-coupled receptor binding|guanyl-nucleotide exchange factor activity|GTPase activator activity|protein binding|nucleoplasm|cytoplasm|cytosol|plasma membrane|striated muscle contraction|G protein-coupled receptor signaling pathway|Rho protein signal transduction|establishment of cell polarity|actin cytoskeleton organization|positive regulation of DNA-templated transcription|regulation of small GTPase mediated signal transduction",null,null,"R-HSA-1266738,R-HSA-162582,R-HSA-193648,R-HSA-193704,R-HSA-194315,R-HSA-204998,R-HSA-372790,R-HSA-373755,R-HSA-388396,R-HSA-400685,R-HSA-416482,R-HSA-416572,R-HSA-422475,R-HSA-73887,R-HSA-8980692,R-HSA-9012999,R-HSA-9013026,R-HSA-9013106,R-HSA-9013148,R-HSA-9013149,R-HSA-9675108,R-HSA-9716542","Developmental Biology|Signal Transduction|NRAGE signals death through JNK|p75 NTR receptor-mediated signalling|Signaling by Rho GTPases|Cell death signalling via NRAGE, NRIF and NADE|Signaling by GPCR|Semaphorin interactions|GPCR downstream signalling|Sema4D in semaphorin signaling|G alpha (12/13) signalling events|Sema4D induced cell migration and growth-cone collapse|Axon guidance|Death Receptor Signaling|RHOA GTPase cycle|RHO GTPase cycle|RHOB GTPase cycle|RHOC GTPase cycle|CDC42 GTPase cycle|RAC1 GTPase cycle|Nervous system development|Signaling by Rho GTPases, Miro GTPases and RHOBTB3"]
["ARHGEF12",25.4021558515742,24.7730059637355,18.9040419573379,16.3372660736953,27.6973415638904,21.0275717893018,19.511314495864,17.7694940182389,24.9335754930302,19.8181896045675,16.2276452584756,21.2063495903795,26.9989831309899,20.8339321926571,24.5271544276456,26.861528936303,20.2468986312555,18.6773803392588,15.5221800393248,23.6823497506005,20.793271067068,19.465635146817,22.9466884795254,23.0716649008293,22.2668853106496,15.9057389587705,20.4340505202384,15.3224171446369,23365,"Rho guanine nucleotide exchange factor 12","protein_coding","hsa04810,hsa04611,hsa04625,hsa04270,hsa04360,hsa05200,hsa05205,hsa05163,hsa05130,hsa05135,hsa05152","Regulation of actin cytoskeleton|Platelet activation|C-type lectin receptor signaling pathway|Vascular smooth muscle contraction|Axon guidance|Pathways in cancer|Proteoglycans in cancer|Human cytomegalovirus infection|Pathogenic Escherichia coli infection|Yersinia infection|Tuberculosis","GO:0001664,GO:0005085,GO:0005096,GO:0005515,GO:0005737,GO:0005829,GO:0007186,GO:0007266,GO:0016020,GO:0051056,GO:0070062","G protein-coupled receptor binding|guanyl-nucleotide exchange factor activity|GTPase activator activity|protein binding|cytoplasm|cytosol|G protein-coupled receptor signaling pathway|Rho protein signal transduction|membrane|regulation of small GTPase mediated signal transduction|extracellular exosome","WP4747","Netrin-UNC5B signaling pathway","R-HSA-1266738,R-HSA-162582,R-HSA-193648,R-HSA-193704,R-HSA-194315,R-HSA-204998,R-HSA-372790,R-HSA-373755,R-HSA-388396,R-HSA-400685,R-HSA-416482,R-HSA-416572,R-HSA-422475,R-HSA-73887,R-HSA-8980692,R-HSA-9012999,R-HSA-9013026,R-HSA-9013106,R-HSA-9013148,R-HSA-9675108,R-HSA-9716542","Developmental Biology|Signal Transduction|NRAGE signals death through JNK|p75 NTR receptor-mediated signalling|Signaling by Rho GTPases|Cell death signalling via NRAGE, NRIF and NADE|Signaling by GPCR|Semaphorin interactions|GPCR downstream signalling|Sema4D in semaphorin signaling|G alpha (12/13) signalling events|Sema4D induced cell migration and growth-cone collapse|Axon guidance|Death Receptor Signaling|RHOA GTPase cycle|RHO GTPase cycle|RHOB GTPase cycle|RHOC GTPase cycle|CDC42 GTPase cycle|Nervous system development|Signaling by Rho GTPases, Miro GTPases and RHOBTB3"]
["ARHGEF15",0,0,0,0,0.00595399611672352,0,0,0,0,0,0,0,0,0,0.0113332411291661,0,0,0,0,0,0,0,0,0,0,0,0,0,22899,"Rho guanine nucleotide exchange factor 15","protein_coding",null,null,"GO:0005085,GO:0005096,GO:0005515,GO:0005737,GO:0005829,GO:0030425,GO:0050790,GO:0051056,GO:0051496,GO:0061299,GO:0090630,GO:0098794,GO:0098978,GO:0150052,GO:2000297","guanyl-nucleotide exchange factor activity|GTPase activator activity|protein binding|cytoplasm|cytosol|dendrite|regulation of catalytic activity|regulation of small GTPase mediated signal transduction|positive regulation of stress fiber assembly|retina vasculature morphogenesis in camera-type eye|activation of GTPase activity|postsynapse|glutamatergic synapse|regulation of postsynapse assembly|negative regulation of synapse maturation","WP3888","VEGFA-VEGFR2 signaling","R-HSA-162582,R-HSA-193648,R-HSA-193704,R-HSA-194315,R-HSA-204998,R-HSA-372790,R-HSA-388396,R-HSA-416482,R-HSA-73887,R-HSA-8980692,R-HSA-9012999,R-HSA-9013148,R-HSA-9013149,R-HSA-9716542","Signal Transduction|NRAGE signals death through JNK|p75 NTR receptor-mediated signalling|Signaling by Rho GTPases|Cell death signalling via NRAGE, NRIF and NADE|Signaling by GPCR|GPCR downstream signalling|G alpha (12/13) signalling events|Death Receptor Signaling|RHOA GTPase cycle|RHO GTPase cycle|CDC42 GTPase cycle|RAC1 GTPase cycle|Signaling by Rho GTPases, Miro GTPases and RHOBTB3"]
["ARHGEF16",0,6.5929115608312E-3,0.0065074465659938,0,0,6.50893798329786E-3,0,0,0.013944097931097,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.0068719510707148,0,0,0,27237,"Rho guanine nucleotide exchange factor 16","protein_coding",null,null,"GO:0005085,GO:0005515,GO:0005829,GO:0030165,GO:0030971,GO:0031267,GO:0045296,GO:0060326,GO:0090630,GO:1903078","guanyl-nucleotide exchange factor activity|protein binding|cytosol|PDZ domain binding|receptor tyrosine kinase binding|small GTPase binding|cadherin binding|cell chemotaxis|activation of GTPase activity|positive regulation of protein localization to plasma membrane",null,null,"R-HSA-162582,R-HSA-193648,R-HSA-193704,R-HSA-194315,R-HSA-204998,R-HSA-372790,R-HSA-388396,R-HSA-416482,R-HSA-73887,R-HSA-9012999,R-HSA-9013148,R-HSA-9013408,R-HSA-9716542","Signal Transduction|NRAGE signals death through JNK|p75 NTR receptor-mediated signalling|Signaling by Rho GTPases|Cell death signalling via NRAGE, NRIF and NADE|Signaling by GPCR|GPCR downstream signalling|G alpha (12/13) signalling events|Death Receptor Signaling|RHO GTPase cycle|CDC42 GTPase cycle|RHOG GTPase cycle|Signaling by Rho GTPases, Miro GTPases and RHOBTB3"]
["ARHGEF17",14.3515510734247,18.073208309158,17.2932757784571,16.1107522758537,17.4086589778238,17.7809912766064,15.6605376770974,16.2361837105071,16.4884696057476,22.7945283472544,17.7141671615068,17.0036927314696,15.5010364558781,18.0522665985352,16.5960523284545,17.0234026882564,13.7663979476474,14.9594821326475,11.6830714828944,14.7057755283063,15.0106454503421,14.5802106458512,11.6416082075282,13.5758566404869,14.7883014840355,13.6428303340626,10.68582077872,14.0260910157072,9828,"Rho guanine nucleotide exchange factor 17","protein_coding",null,null,"GO:0005085,GO:0005515,GO:0005829,GO:0030036,GO:0051056","guanyl-nucleotide exchange factor activity|protein binding|cytosol|actin cytoskeleton organization|regulation of small GTPase mediated signal transduction",null,null,"R-HSA-162582,R-HSA-193648,R-HSA-193704,R-HSA-194315,R-HSA-204998,R-HSA-372790,R-HSA-388396,R-HSA-416482,R-HSA-73887,R-HSA-8980692,R-HSA-9012999,R-HSA-9013026,R-HSA-9013106,R-HSA-9716542","Signal Transduction|NRAGE signals death through JNK|p75 NTR receptor-mediated signalling|Signaling by Rho GTPases|Cell death signalling via NRAGE, NRIF and NADE|Signaling by GPCR|GPCR downstream signalling|G alpha (12/13) signalling events|Death Receptor Signaling|RHOA GTPase cycle|RHO GTPase cycle|RHOB GTPase cycle|RHOC GTPase cycle|Signaling by Rho GTPases, Miro GTPases and RHOBTB3"]
["ARHGEF17-AS1",1.44374373352958,1.87917028770087,2.33634758285034,1.74901170645126,1.72633159287934,1.94442940102744,1.87871033863428,2.66380889969373,1.16558999580557,2.2687272746379,1.98304058053436,1.58631145455755,1.46331561360123,2.44497948551128,2.75601422334293,1.99929748339204,1.82641071824796,2.33772915001166,2.12440774558646,1.82675604255911,1.61370000120031,1.75152852858857,1.70660071167271,1.94871447995478,2.05287310135805,2.11187498257378,1.52576311119121,2.17880146117723,100287837,"ARHGEF17 antisense RNA 1","non_coding"]
["ARHGEF18",7.17229542399553,7.24674999033673,7.82118643190778,7.00442290627982,6.7979366166822,7.45352791091501,7.39668826197355,6.90453171530004,8.07178813360787,10.3031167288392,9.63464035382402,8.68298520653232,7.90166324313696,9.16582992490214,8.0669571888444,8.98828557446287,8.17760642678567,9.90673830649693,8.87974831964948,9.35618188903455,8.77363936596082,9.18600736027058,7.96841110522408,8.00161881244995,8.92794522034107,8.94520534880633,7.62034712661279,8.55397603431568,23370,"Rho/Rac guanine nucleotide exchange factor 18","protein_coding","hsa04530","Tight junction","GO:0005085,GO:0005515,GO:0005829,GO:0005856,GO:0005886,GO:0007264,GO:0008360,GO:0016324,GO:0030036,GO:0030054,GO:0035023,GO:0045177,GO:0046872,GO:0051497,GO:0070062,GO:0150105","guanyl-nucleotide exchange factor activity|protein binding|cytosol|cytoskeleton|plasma membrane|small GTPase mediated signal transduction|regulation of cell shape|apical plasma membrane|actin cytoskeleton organization|cell junction|regulation of Rho protein signal transduction|apical part of cell|metal ion binding|negative regulation of stress fiber assembly|extracellular exosome|protein localization to cell-cell junction",null,null,"R-HSA-162582,R-HSA-162582,R-HSA-170834,R-HSA-170834,R-HSA-193648,R-HSA-193704,R-HSA-194315,R-HSA-204998,R-HSA-2173791,R-HSA-2173791,R-HSA-372790,R-HSA-388396,R-HSA-416482,R-HSA-73887,R-HSA-8980692,R-HSA-9006936,R-HSA-9006936,R-HSA-9012999,R-HSA-9013149,R-HSA-9716542","Signal Transduction|Signal Transduction|Signaling by TGF-beta Receptor Complex|Signaling by TGF-beta Receptor Complex|NRAGE signals death through JNK|p75 NTR receptor-mediated signalling|Signaling by Rho GTPases|Cell death signalling via NRAGE, NRIF and NADE|TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)|TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)|Signaling by GPCR|GPCR downstream signalling|G alpha (12/13) signalling events|Death Receptor Signaling|RHOA GTPase cycle|Signaling by TGFB family members|Signaling by TGFB family members|RHO GTPase cycle|RAC1 GTPase cycle|Signaling by Rho GTPases, Miro GTPases and RHOBTB3"]
["ARHGEF19",3.99960104100151,4.60832075034404,5.65817188306196,5.84010066332595,4.28300468624144,5.02002219948954,4.8123657511396,5.23444517504814,7.96738385834565,10.3803930906796,11.2768198050357,9.63853521303688,7.45085853571018,10.8498843807233,9.17891177273498,8.80895542069203,6.92317846822982,7.6910621480231,7.23388763543064,7.09007302141892,7.32843456991104,8.07224755302184,5.40115895296372,6.01800990441054,6.97612976913323,7.85354098763969,5.46846539870773,7.85865697531084,128272,"Rho guanine nucleotide exchange factor 19","protein_coding",null,null,"GO:0005085,GO:0005096,GO:0005515,GO:0005829,GO:0032956,GO:0042060,GO:0051056,GO:0060071,GO:0090630","guanyl-nucleotide exchange factor activity|GTPase activator activity|protein binding|cytosol|regulation of actin cytoskeleton organization|wound healing|regulation of small GTPase mediated signal transduction|Wnt signaling pathway, planar cell polarity pathway|activation of GTPase activity",null,null,"R-HSA-162582,R-HSA-193648,R-HSA-193704,R-HSA-194315,R-HSA-204998,R-HSA-372790,R-HSA-388396,R-HSA-416482,R-HSA-73887,R-HSA-8980692,R-HSA-9012999,R-HSA-9013148,R-HSA-9013149,R-HSA-9716542","Signal Transduction|NRAGE signals death through JNK|p75 NTR receptor-mediated signalling|Signaling by Rho GTPases|Cell death signalling via NRAGE, NRIF and NADE|Signaling by GPCR|GPCR downstream signalling|G alpha (12/13) signalling events|Death Receptor Signaling|RHOA GTPase cycle|RHO GTPase cycle|CDC42 GTPase cycle|RAC1 GTPase cycle|Signaling by Rho GTPases, Miro GTPases and RHOBTB3"]
["ARHGEF2",30.300429102161,35.9474972200888,44.1563296548343,37.4665411759939,35.8895384313807,38.2877316872115,44.6911497445642,40.8100167847031,32.3229906554323,32.0641808632618,31.7986377380603,29.3089005823072,33.6024228527842,40.1846964588118,39.2582888902795,41.0835492915611,22.1396731070864,22.5165321775506,19.0046385585678,22.2662623550424,23.5640955423184,22.1085988274774,16.998599510233,19.620190139169,22.767030544517,20.951300098582,17.4740056549945,23.0574315884064,9181,"Rho/Rac guanine nucleotide exchange factor 2","protein_coding","hsa04530,hsa05130,hsa05131,hsa05418","Tight junction|Pathogenic Escherichia coli infection|Shigellosis|Fluid shear stress and atherosclerosis","GO:0000902,GO:0005085,GO:0005515,GO:0005737,GO:0005794,GO:0005819,GO:0005829,GO:0005856,GO:0005874,GO:0005923,GO:0005925,GO:0006886,GO:0007015,GO:0007026,GO:0007049,GO:0008017,GO:0008270,GO:0031267,GO:0031410,GO:0031982,GO:0032587,GO:0032755,GO:0032760,GO:0032991,GO:0035023,GO:0042127,GO:0045087,GO:0045666,GO:0045944,GO:0050731,GO:0051056,GO:0051092,GO:0055059,GO:0060546,GO:0071225,GO:0071356,GO:0071474,GO:1902042,GO:1902219,GO:2001224","cell morphogenesis|guanyl-nucleotide exchange factor activity|protein binding|cytoplasm|Golgi apparatus|spindle|cytosol|cytoskeleton|microtubule|bicellular tight junction|focal adhesion|intracellular protein transport|actin filament organization|negative regulation of microtubule depolymerization|cell cycle|microtubule binding|zinc ion binding|small GTPase binding|cytoplasmic vesicle|vesicle|ruffle membrane|positive regulation of interleukin-6 production|positive regulation of tumor necrosis factor production|protein-containing complex|regulation of Rho protein signal transduction|regulation of cell population proliferation|innate immune response|positive regulation of neuron differentiation|positive regulation of transcription by RNA polymerase II|positive regulation of peptidyl-tyrosine phosphorylation|regulation of small GTPase mediated signal transduction|positive regulation of NF-kappaB transcription factor activity|asymmetric neuroblast division|negative regulation of necroptotic process|cellular response to muramyl dipeptide|cellular response to tumor necrosis factor|cellular hyperosmotic response|negative regulation of extrinsic apoptotic signaling pathway via death domain receptors|negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress|positive regulation of neuron migration","WP2272","Pathogenic Escherichia coli infection","R-HSA-162582,R-HSA-193648,R-HSA-193704,R-HSA-194315,R-HSA-204998,R-HSA-372790,R-HSA-388396,R-HSA-416482,R-HSA-73887,R-HSA-8980692,R-HSA-9012999,R-HSA-9013026,R-HSA-9716542","Signal Transduction|NRAGE signals death through JNK|p75 NTR receptor-mediated signalling|Signaling by Rho GTPases|Cell death signalling via NRAGE, NRIF and NADE|Signaling by GPCR|GPCR downstream signalling|G alpha (12/13) signalling events|Death Receptor Signaling|RHOA GTPase cycle|RHO GTPase cycle|RHOB GTPase cycle|Signaling by Rho GTPases, Miro GTPases and RHOBTB3"]
["ARHGEF2-AS1",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.0646303443689241,0,0,0,0,0,0,0,0,0,0,0,107985210,null,"non_coding"]
["ARHGEF2-AS2",0.143193706428914,0.0113500810358886,0.100826532649999,0.022888516410786,0.01166023852164,0.156877218875004,0.211530855362277,0.093610201398983,0.048011152593215,0.0344784732329947,0.213220220586271,0.0360161915233391,0.0907839634362481,0.0568823617454545,0.0443897819879867,0.0565705771295858,0.114726729047979,0.198738140003388,0.17645690317077,0.0917987365875653,0.14641642773175,0.113425746364698,0.188484949373773,0.303108716555794,0.0828132465684236,0.124721462121104,0.207848879640986,0.14583687310625,107985209,null,"non_coding"]
["ARHGEF25",14.0371507708097,15.2283985829081,15.2867994603327,16.2648677627044,15.5619071455393,16.8872705785377,15.0513724438413,16.2155447512257,16.0285291503042,19.0124684606758,18.6618366601028,17.4593917828289,14.7877749643217,18.3094032481014,15.0991479835107,16.4896981767057,15.1038118681496,16.4133181753094,14.9619993151959,15.8023693825741,16.2464173839911,16.5311759038364,14.256609194766,15.8251568003593,17.708002326362,18.9175612038406,15.1655062289181,17.9222165881465,115557,"Rho guanine nucleotide exchange factor 25","protein_coding",null,null,"GO:0005085,GO:0005737,GO:0005829,GO:0005886,GO:0007411,GO:0019898,GO:0030016,GO:0030017,GO:0051056","guanyl-nucleotide exchange factor activity|cytoplasm|cytosol|plasma membrane|axon guidance|extrinsic component of membrane|myofibril|sarcomere|regulation of small GTPase mediated signal transduction",null,null,"R-HSA-162582,R-HSA-194315,R-HSA-372790,R-HSA-388396,R-HSA-416476,R-HSA-8980692,R-HSA-9012999,R-HSA-9013026,R-HSA-9013106,R-HSA-9013148,R-HSA-9013149,R-HSA-9716542","Signal Transduction|Signaling by Rho GTPases|Signaling by GPCR|GPCR downstream signalling|G alpha (q) signalling events|RHOA GTPase cycle|RHO GTPase cycle|RHOB GTPase cycle|RHOC GTPase cycle|CDC42 GTPase cycle|RAC1 GTPase cycle|Signaling by Rho GTPases, Miro GTPases and RHOBTB3"]
["ARHGEF26",0.325904049372787,0.366350426577332,0.27815489681425,0.331504039204761,0.342585454524148,0.333862375311827,0.221138570864555,0.261474950262327,0.352649787198808,0.351934325973426,0.366863930988387,0.412342178790469,0.230100927292584,0.197724298138312,0.394934077025743,0.248141618904338,0.204143804351229,0.23301400716096,0.287516224223238,0.256415109941627,0.274980313448722,0.464675716115545,0.229117197859746,0.270157010153833,0.323108842118456,0.309667466127394,0.253252761115959,0.273891869241678,26084,"Rho guanine nucleotide exchange factor 26","protein_coding","hsa05132,hsa05100","Salmonella infection|Bacterial invasion of epithelial cells","GO:0001726,GO:0001886,GO:0005085,GO:0005829,GO:0090630,GO:0097178","ruffle|endothelial cell morphogenesis|guanyl-nucleotide exchange factor activity|cytosol|activation of GTPase activity|ruffle assembly","WP3584","MECP2 and associated Rett syndrome","R-HSA-162582,R-HSA-193648,R-HSA-193704,R-HSA-194315,R-HSA-204998,R-HSA-372790,R-HSA-388396,R-HSA-416482,R-HSA-73887,R-HSA-9012999,R-HSA-9013148,R-HSA-9013408,R-HSA-9716542","Signal Transduction|NRAGE signals death through JNK|p75 NTR receptor-mediated signalling|Signaling by Rho GTPases|Cell death signalling via NRAGE, NRIF and NADE|Signaling by GPCR|GPCR downstream signalling|G alpha (12/13) signalling events|Death Receptor Signaling|RHO GTPase cycle|CDC42 GTPase cycle|RHOG GTPase cycle|Signaling by Rho GTPases, Miro GTPases and RHOBTB3"]
["ARHGEF26-AS1",0.0415030257663481,0,0,0,0,0,0.0096804870601553,0,0,0,0,0.0104388730627691,0,0,0,0.00983779320521435,0,0,0,0,0,0,0.0102431558082023,0,0,0,0,0.00975441156946229,100507524,"ARHGEF26 antisense RNA 1","non_coding"]
["ARHGEF28",8.96992367752117,8.00766208251059,6.17715964302705,6.61013570992392,8.47760414136438,6.8502228496392,6.01448460899542,6.1209846232479,6.82061952161381,6.05965701584107,4.78711839585773,6.13054655217118,6.69587258093915,6.09867514835838,4.78288811123196,5.88323085702761,8.66273778400428,8.24512176081825,6.11820379934673,8.12248001026841,7.96654243873071,8.43206294938494,6.42826149951291,8.20374836972358,8.70880717374752,7.99053470377958,5.72276771127299,7.0530177035186,64283,"Rho guanine nucleotide exchange factor 28","protein_coding","hsa05135","Yersinia infection","GO:0000902,GO:0003723,GO:0005085,GO:0005829,GO:0005886,GO:0021955,GO:0035023,GO:0046872,GO:0048013,GO:0051056,GO:0060052","cell morphogenesis|RNA binding|guanyl-nucleotide exchange factor activity|cytosol|plasma membrane|central nervous system neuron axonogenesis|regulation of Rho protein signal transduction|metal ion binding|ephrin receptor signaling pathway|regulation of small GTPase mediated signal transduction|neurofilament cytoskeleton organization","WP4659","Gastrin signaling pathway","R-HSA-1266738,R-HSA-162582,R-HSA-194315,R-HSA-2682334,R-HSA-3928662,R-HSA-422475,R-HSA-8980692,R-HSA-9012999,R-HSA-9013026,R-HSA-9013106,R-HSA-9675108,R-HSA-9716542","Developmental Biology|Signal Transduction|Signaling by Rho GTPases|EPH-Ephrin signaling|EPHB-mediated forward signaling|Axon guidance|RHOA GTPase cycle|RHO GTPase cycle|RHOB GTPase cycle|RHOC GTPase cycle|Nervous system development|Signaling by Rho GTPases, Miro GTPases and RHOBTB3"]
["ARHGEF3",0.659562816672373,0.501140504286925,0.340754850390754,0.400496016157544,0.644497020507462,0.469103410537397,0.262167827931722,0.466895618306734,0.855786456795999,0.556307944256243,0.660653997811447,0.867751915444249,0.649507209089235,0.863221751916947,0.994489858041704,0.802984410616892,0.318940971161833,0.3069406556372,0.403983351648963,0.461613608513304,0.508337695470052,0.367259987588643,0.558665010063399,0.282152285372508,0.297933453594724,0.26328955589378,0.441863185783759,0.359564529206801,50650,"Rho guanine nucleotide exchange factor 3","protein_coding",null,null,"GO:0005085,GO:0005515,GO:0005829,GO:0007266,GO:0035025,GO:0051056","guanyl-nucleotide exchange factor activity|protein binding|cytosol|Rho protein signal transduction|positive regulation of Rho protein signal transduction|regulation of small GTPase mediated signal transduction",null,null,"R-HSA-162582,R-HSA-193648,R-HSA-193704,R-HSA-194315,R-HSA-204998,R-HSA-372790,R-HSA-388396,R-HSA-416482,R-HSA-73887,R-HSA-8980692,R-HSA-9012999,R-HSA-9013026,R-HSA-9716542","Signal Transduction|NRAGE signals death through JNK|p75 NTR receptor-mediated signalling|Signaling by Rho GTPases|Cell death signalling via NRAGE, NRIF and NADE|Signaling by GPCR|GPCR downstream signalling|G alpha (12/13) signalling events|Death Receptor Signaling|RHOA GTPase cycle|RHO GTPase cycle|RHOB GTPase cycle|Signaling by Rho GTPases, Miro GTPases and RHOBTB3"]
["ARHGEF33",0.168700000523994,0.213948919901989,0.0671921933874641,0.117667722902254,0.169841888847541,0.100811389371885,0.138317325258149,0.11529739318431,0.138836726252511,0.0689307917356782,0.115383707260475,0.169726217174939,0.0388926556803498,0.0389902538010185,0.114101859485145,0.111482551713328,0.157279836704349,0.104061445960431,0.0661462405139245,0.0786547870097895,0.197828460226801,0.0485925964418461,0.156450461308742,0.209764904005752,0.192594476224611,0.1991548213057,0.084097398959614,0.120149636153342,100271715,"Rho guanine nucleotide exchange factor 33","protein_coding",null,null,"GO:0005085","guanyl-nucleotide exchange factor activity",null,null,"R-HSA-162582,R-HSA-193648,R-HSA-193704,R-HSA-204998,R-HSA-372790,R-HSA-388396,R-HSA-416482,R-HSA-73887","Signal Transduction|NRAGE signals death through JNK|p75 NTR receptor-mediated signalling|Cell death signalling via NRAGE, NRIF and NADE|Signaling by GPCR|GPCR downstream signalling|G alpha (12/13) signalling events|Death Receptor Signaling"]
["ARHGEF35",0.335049002923925,0.444230629289392,0.514727993799658,0.438179309931911,0.436527709264381,0.343230641587056,0.284179721833711,0.358416008407292,0.337013878753898,0.136900966034738,0.286449288316614,0.398375704883578,0.280006978751038,0.406544988149546,0.169960199170952,0.385063453817655,0.429505761222334,0.263037975130661,0.215823241950181,0.517457030857789,0.450397548357618,0.289524023771587,0.28065089495739,0.367010515078704,0.392570881674721,0.270120935527617,0.235796921084237,0.50588472566687,445328,"Rho guanine nucleotide exchange factor 35","protein_coding",{"$nulls":6},"R-HSA-162582,R-HSA-193648,R-HSA-193704,R-HSA-204998,R-HSA-372790,R-HSA-388396,R-HSA-416482,R-HSA-73887","Signal Transduction|NRAGE signals death through JNK|p75 NTR receptor-mediated signalling|Cell death signalling via NRAGE, NRIF and NADE|Signaling by GPCR|GPCR downstream signalling|G alpha (12/13) signalling events|Death Receptor Signaling"]
["ARHGEF35-AS1",0.76239800665334,0.181291748909603,0.664640355630199,0.470046896108777,0.69177015083839,0.741499529994258,0.508078896611787,0.10680072977793,1.04075084871383,0.524490714029193,0.563350267022674,0.13697066776300099,0.310728747579522,1.01240261659318,1.74724235056805,0.206534034320379,0.471213965307974,0.327516439813664,0.150990963735897,0.47130305898025,0.385495000286742,0.491752167648407,0.0268805240300097,1.59608995501058,0.296944641266776,0.413951563535829,0.0526970391817046,0.460762931953873,101928605,"ARHGEF35 antisense RNA 1","non_coding"]
["ARHGEF37",0.386469035630725,0.251513170934497,0.243478672788652,0.209707773872337,0.248448206191141,0.272185589430595,0.161308580078784,0.294200652062296,0.506379087771137,0.705257462667438,0.593000281076499,0.567881783832343,0.415887655928449,0.620548902600326,0.406705362475671,0.438753328426781,0.655130527130687,0.508148792606286,0.230288991096912,0.39119665336976,0.84472928189602,0.589698337042412,0.326308568445789,0.392473732570513,0.806640791217049,0.579813310555279,0.246038807724427,0.482840612526649,389337,"Rho guanine nucleotide exchange factor 37","protein_coding",null,null,"GO:0005085,GO:0005737","guanyl-nucleotide exchange factor activity|cytoplasm",null,null,"R-HSA-162582,R-HSA-193648,R-HSA-193704,R-HSA-204998,R-HSA-372790,R-HSA-388396,R-HSA-416482,R-HSA-73887","Signal Transduction|NRAGE signals death through JNK|p75 NTR receptor-mediated signalling|Cell death signalling via NRAGE, NRIF and NADE|Signaling by GPCR|GPCR downstream signalling|G alpha (12/13) signalling events|Death Receptor Signaling"]
["ARHGEF38",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,3.85621196778867E-3,0,0,0,0,0,54848,"Rho guanine nucleotide exchange factor 38","protein_coding",null,null,"GO:0005085,GO:0005737","guanyl-nucleotide exchange factor activity|cytoplasm",null,null,"R-HSA-162582,R-HSA-193648,R-HSA-193704,R-HSA-204998,R-HSA-372790,R-HSA-388396,R-HSA-416482,R-HSA-73887","Signal Transduction|NRAGE signals death through JNK|p75 NTR receptor-mediated signalling|Cell death signalling via NRAGE, NRIF and NADE|Signaling by GPCR|GPCR downstream signalling|G alpha (12/13) signalling events|Death Receptor Signaling"]
["ARHGEF39",1.54234015005772,0.878891184791146,0.502235669207871,1.37924843097897,1.37133420662828,0.848124684591726,0.557446356411437,1.06959004055307,0.86653943426553,0.903327112500022,0.444291705435408,0.999532857484957,0.601236101147748,0.397414191287572,0.355361370044936,0.414997671409859,1.50958494556137,1.00923632514349,0.802625934807446,1.25599835821025,1.10164138226273,1.41982432018398,0.987651418999534,1.48646161145122,1.39135401500773,1.51171003494213,1.05550268041396,1.30628666275582,84904,"Rho guanine nucleotide exchange factor 39","protein_coding",null,null,"GO:0005085,GO:0005515,GO:0005886,GO:0030335","guanyl-nucleotide exchange factor activity|protein binding|plasma membrane|positive regulation of cell migration",null,null,"R-HSA-162582,R-HSA-193648,R-HSA-193704,R-HSA-194315,R-HSA-204998,R-HSA-372790,R-HSA-388396,R-HSA-416482,R-HSA-73887,R-HSA-9012999,R-HSA-9013149,R-HSA-9716542","Signal Transduction|NRAGE signals death through JNK|p75 NTR receptor-mediated signalling|Signaling by Rho GTPases|Cell death signalling via NRAGE, NRIF and NADE|Signaling by GPCR|GPCR downstream signalling|G alpha (12/13) signalling events|Death Receptor Signaling|RHO GTPase cycle|RAC1 GTPase cycle|Signaling by Rho GTPases, Miro GTPases and RHOBTB3"]
["ARHGEF4",0.00351175289672265,0,0,0,0,0,0,0,0,3.38226815326277E-3,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,50649,"Rho guanine nucleotide exchange factor 4","protein_coding","hsa04810","Regulation of actin cytoskeleton","GO:0005085,GO:0005515,GO:0005829,GO:0019904,GO:0030032,GO:0032587,GO:0035556,GO:0046847,GO:0051056","guanyl-nucleotide exchange factor activity|protein binding|cytosol|protein domain specific binding|lamellipodium assembly|ruffle membrane|intracellular signal transduction|filopodium assembly|regulation of small GTPase mediated signal transduction","WP51,WP5223","Regulation of actin cytoskeleton|2q21.1 copy number variation syndrome","R-HSA-162582,R-HSA-193648,R-HSA-193704,R-HSA-194315,R-HSA-204998,R-HSA-372790,R-HSA-388396,R-HSA-416482,R-HSA-73887,R-HSA-8980692,R-HSA-9012999,R-HSA-9013148,R-HSA-9013149,R-HSA-9716542","Signal Transduction|NRAGE signals death through JNK|p75 NTR receptor-mediated signalling|Signaling by Rho GTPases|Cell death signalling via NRAGE, NRIF and NADE|Signaling by GPCR|GPCR downstream signalling|G alpha (12/13) signalling events|Death Receptor Signaling|RHOA GTPase cycle|RHO GTPase cycle|CDC42 GTPase cycle|RAC1 GTPase cycle|Signaling by Rho GTPases, Miro GTPases and RHOBTB3"]
["ARHGEF40",18.8589313655731,21.1942739320422,19.6758162621596,20.3066228792438,18.5154221636388,20.5049984271703,18.5673238520778,19.4125512008008,18.9545564928796,25.0447936122283,21.3437738177399,20.0256637450484,18.2637856110267,17.983229887425,17.068048880576,17.2354633158217,18.804325385316,19.9181898895513,18.8674089541823,19.7811957554328,18.69565606167,19.6062399562786,15.9986244242387,17.2176771734327,19.0661087170075,18.6972503908207,15.9736626968485,19.6991418885663,55701,"Rho guanine nucleotide exchange factor 40","protein_coding",null,null,"GO:0005085,GO:0005737,GO:0005829,GO:0005886,GO:0007411,GO:0019898,GO:0051056","guanyl-nucleotide exchange factor activity|cytoplasm|cytosol|plasma membrane|axon guidance|extrinsic component of membrane|regulation of small GTPase mediated signal transduction",null,null,"R-HSA-162582,R-HSA-193648,R-HSA-193704,R-HSA-194315,R-HSA-204998,R-HSA-372790,R-HSA-388396,R-HSA-416482,R-HSA-73887,R-HSA-8980692,R-HSA-9012999,R-HSA-9013106,R-HSA-9716542","Signal Transduction|NRAGE signals death through JNK|p75 NTR receptor-mediated signalling|Signaling by Rho GTPases|Cell death signalling via NRAGE, NRIF and NADE|Signaling by GPCR|GPCR downstream signalling|G alpha (12/13) signalling events|Death Receptor Signaling|RHOA GTPase cycle|RHO GTPase cycle|RHOC GTPase cycle|Signaling by Rho GTPases, Miro GTPases and RHOBTB3"]
["ARHGEF5",1.53249620142052,1.56044173507001,1.49409929687109,1.53099276019395,1.46869287883341,1.45754192824095,1.39772615553871,1.32936549765496,0.92390193255328,1.10226196251015,1.05320221203583,0.998228649389398,0.789419745467836,1.18475967788973,0.740014387607491,0.721862417239025,0.87365198560653,0.913496528909523,0.739960271442596,1.05330393921151,1.07556476756388,1.1252028318171,0.814644452746214,0.777395854545059,1.26125721354383,1.24145869102502,0.632162823346852,0.835804480247961,7984,"Rho guanine nucleotide exchange factor 5","protein_coding",null,null,"GO:0002102,GO:0002408,GO:0005085,GO:0005515,GO:0005525,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0008289,GO:0030036,GO:0032956,GO:0035556,GO:0042995,GO:0043087,GO:0043507,GO:0051056,GO:0051091,GO:0051493,GO:0051496,GO:0061484,GO:0070161,GO:0070372,GO:0071803,GO:0071944,GO:0090630,GO:1904591","podosome|myeloid dendritic cell chemotaxis|guanyl-nucleotide exchange factor activity|protein binding|GTP binding|nucleus|nucleoplasm|cytoplasm|cytosol|plasma membrane|lipid binding|actin cytoskeleton organization|regulation of actin cytoskeleton organization|intracellular signal transduction|cell projection|regulation of GTPase activity|positive regulation of JUN kinase activity|regulation of small GTPase mediated signal transduction|positive regulation of DNA-binding transcription factor activity|regulation of cytoskeleton organization|positive regulation of stress fiber assembly|hematopoietic stem cell homeostasis|anchoring junction|regulation of ERK1 and ERK2 cascade|positive regulation of podosome assembly|cell periphery|activation of GTPase activity|positive regulation of protein import",null,null,"R-HSA-162582,R-HSA-193648,R-HSA-193704,R-HSA-194315,R-HSA-204998,R-HSA-372790,R-HSA-388396,R-HSA-416482,R-HSA-73887,R-HSA-8980692,R-HSA-9012999,R-HSA-9013026,R-HSA-9013106,R-HSA-9013148,R-HSA-9013149,R-HSA-9013408,R-HSA-9716542","Signal Transduction|NRAGE signals death through JNK|p75 NTR receptor-mediated signalling|Signaling by Rho GTPases|Cell death signalling via NRAGE, NRIF and NADE|Signaling by GPCR|GPCR downstream signalling|G alpha (12/13) signalling events|Death Receptor Signaling|RHOA GTPase cycle|RHO GTPase cycle|RHOB GTPase cycle|RHOC GTPase cycle|CDC42 GTPase cycle|RAC1 GTPase cycle|RHOG GTPase cycle|Signaling by Rho GTPases, Miro GTPases and RHOBTB3"]
["ARHGEF6",4.783059955348,5.58887871321069,6.46666772074107,4.82346677822871,5.35649544378651,5.82469926011095,6.36791091586642,5.43243801744256,7.18963620028593,5.86620948138317,6.0818242816304,7.17768170822386,7.09980857829252,7.241446911126,8.5382480851166,8.58605456101197,4.97322929825371,4.703232681082,4.97939048791444,5.20242153823689,4.83575585672872,4.87000668927239,4.76614601350839,4.83918351702743,4.96404216718109,4.22135686489935,4.76282651603974,4.18506554077392,9459,"Rac/Cdc42 guanine nucleotide exchange factor 6","protein_coding","hsa04810,hsa05212","Regulation of actin cytoskeleton|Pancreatic cancer","GO:0005085,GO:0005096,GO:0005515,GO:0005737,GO:0005829,GO:0005911,GO:0006915,GO:0007254,GO:0030027,GO:0030032","guanyl-nucleotide exchange factor activity|GTPase activator activity|protein binding|cytoplasm|cytosol|cell-cell junction|apoptotic process|JNK cascade|lamellipodium|lamellipodium assembly","WP51,WP4263","Regulation of actin cytoskeleton|Pancreatic adenocarcinoma pathway","R-HSA-1500931,R-HSA-162582,R-HSA-193648,R-HSA-193704,R-HSA-194315,R-HSA-204998,R-HSA-372790,R-HSA-388396,R-HSA-397795,R-HSA-416482,R-HSA-446353,R-HSA-446388,R-HSA-446728,R-HSA-73887,R-HSA-8964616,R-HSA-9012999,R-HSA-9013148,R-HSA-9013149,R-HSA-9013420,R-HSA-9716542","Cell-Cell communication|Signal Transduction|NRAGE signals death through JNK|p75 NTR receptor-mediated signalling|Signaling by Rho GTPases|Cell death signalling via NRAGE, NRIF and NADE|Signaling by GPCR|GPCR downstream signalling|G-protein beta:gamma signalling|G alpha (12/13) signalling events|Cell-extracellular matrix interactions|Regulation of cytoskeletal remodeling and cell spreading by IPP complex components|Cell junction organization|Death Receptor Signaling|G beta:gamma signalling through CDC42|RHO GTPase cycle|CDC42 GTPase cycle|RAC1 GTPase cycle|RHOU GTPase cycle|Signaling by Rho GTPases, Miro GTPases and RHOBTB3"]
["ARHGEF7",4.11027592090136,4.58927580020234,4.12586899268088,3.8277669240382,4.36791168175723,4.00355795483296,3.57632108096131,4.1044127166551,4.34219963989038,4.23028481987486,4.25408188564597,4.85424540585145,4.38501585374789,4.5350609268367,4.24525022284488,4.2428636791251,3.73444503254444,4.10896032589421,3.51125469726504,3.9127928440317,3.91160977297269,3.67592388468193,3.52743251766214,4.10349114492891,4.04128536577047,3.57061218470541,3.46938013819135,3.65161894404201,8874,"Rho guanine nucleotide exchange factor 7","protein_coding","hsa04810,hsa05135","Regulation of actin cytoskeleton|Yersinia infection","GO:0001726,GO:0005085,GO:0005515,GO:0005737,GO:0005813,GO:0005829,GO:0005925,GO:0005938,GO:0007030,GO:0007165,GO:0007399,GO:0010763,GO:0019901,GO:0030027,GO:0030032,GO:0032991,GO:0035556,GO:0043005,GO:0043015,GO:0043025,GO:0043065,GO:0043547,GO:0048013,GO:0048041,GO:0097431,GO:0098794,GO:1900026,GO:1904424,GO:1905833,GO:2000394","ruffle|guanyl-nucleotide exchange factor activity|protein binding|cytoplasm|centrosome|cytosol|focal adhesion|cell cortex|Golgi organization|signal transduction|nervous system development|positive regulation of fibroblast migration|protein kinase binding|lamellipodium|lamellipodium assembly|protein-containing complex|intracellular signal transduction|neuron projection|gamma-tubulin binding|neuronal cell body|positive regulation of apoptotic process|positive regulation of GTPase activity|ephrin receptor signaling pathway|focal adhesion assembly|mitotic spindle pole|postsynapse|positive regulation of substrate adhesion-dependent cell spreading|regulation of GTP binding|negative regulation of microtubule nucleation|positive regulation of lamellipodium morphogenesis","WP185,WP4874,WP51","Integrin-mediated cell adhesion|CAMKK2 pathway|Regulation of actin cytoskeleton","R-HSA-112314,R-HSA-112315,R-HSA-112316,R-HSA-1266738,R-HSA-162582,R-HSA-177929,R-HSA-182971,R-HSA-193648,R-HSA-193704,R-HSA-194315,R-HSA-204998,R-HSA-2682334,R-HSA-372790,R-HSA-388396,R-HSA-3928664,R-HSA-416482,R-HSA-422475,R-HSA-438064,R-HSA-442755,R-HSA-73887,R-HSA-8980692,R-HSA-9006934,R-HSA-9012999,R-HSA-9013148,R-HSA-9013149,R-HSA-9013406,R-HSA-9013409,R-HSA-9013420,R-HSA-9013424,R-HSA-9619229,R-HSA-9675108,R-HSA-9716542","Neurotransmitter receptors and postsynaptic signal transmission|Transmission across Chemical Synapses|Neuronal System|Developmental Biology|Signal Transduction|Signaling by EGFR|EGFR downregulation|NRAGE signals death through JNK|p75 NTR receptor-mediated signalling|Signaling by Rho GTPases|Cell death signalling via NRAGE, NRIF and NADE|EPH-Ephrin signaling|Signaling by GPCR|GPCR downstream signalling|Ephrin signaling|G alpha (12/13) signalling events|Axon guidance|Post NMDA receptor activation events|Activation of NMDA receptors and postsynaptic events|Death Receptor Signaling|RHOA GTPase cycle|Signaling by Receptor Tyrosine Kinases|RHO GTPase cycle|CDC42 GTPase cycle|RAC1 GTPase cycle|RHOQ GTPase cycle|RHOJ GTPase cycle|RHOU GTPase cycle|RHOV GTPase cycle|Activation of RAC1 downstream of NMDARs|Nervous system development|Signaling by Rho GTPases, Miro GTPases and RHOBTB3"]
["ARHGEF7-AS2",0.0217564287612938,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,100874238,"ARHGEF7 antisense RNA 2","non_coding"]
["ARHGEF9",3.55930786116243,3.36560105024381,3.5614997584951,3.53793249499407,3.74774539616647,3.93936378533692,3.59005631523674,3.5640704358127,3.90832943967415,3.89937890665986,3.39845746809023,3.58516738075211,3.6792067571237,4.12706467383665,3.83524617012063,3.74356957165348,3.1244885659327,2.89470041189729,3.1929493324384,3.19345300010357,3.11075624125879,3.41505827356892,3.28672275509835,3.3506744905032,3.17631707818953,3.10379372973495,3.07192259205001,3.25572442531876,23229,"Cdc42 guanine nucleotide exchange factor 9","protein_coding",null,null,"GO:0005085,GO:0005515,GO:0005829,GO:0014069,GO:0051056,GO:0098982,GO:0099150,GO:0099572","guanyl-nucleotide exchange factor activity|protein binding|cytosol|postsynaptic density|regulation of small GTPase mediated signal transduction|GABA-ergic synapse|regulation of postsynaptic specialization assembly|postsynaptic specialization","WP2858","Ectoderm differentiation","R-HSA-112314,R-HSA-112314,R-HSA-112315,R-HSA-112315,R-HSA-112316,R-HSA-112316,R-HSA-162582,R-HSA-193648,R-HSA-193704,R-HSA-194315,R-HSA-204998,R-HSA-372790,R-HSA-388396,R-HSA-416482,R-HSA-73887,R-HSA-9012999,R-HSA-9013148,R-HSA-9013406,R-HSA-9716542,R-HSA-977443,R-HSA-977443","Neurotransmitter receptors and postsynaptic signal transmission|Neurotransmitter receptors and postsynaptic signal transmission|Transmission across Chemical Synapses|Transmission across Chemical Synapses|Neuronal System|Neuronal System|Signal Transduction|NRAGE signals death through JNK|p75 NTR receptor-mediated signalling|Signaling by Rho GTPases|Cell death signalling via NRAGE, NRIF and NADE|Signaling by GPCR|GPCR downstream signalling|G alpha (12/13) signalling events|Death Receptor Signaling|RHO GTPase cycle|CDC42 GTPase cycle|RHOQ GTPase cycle|Signaling by Rho GTPases, Miro GTPases and RHOBTB3|GABA receptor activation|GABA receptor activation"]
["ARHGEF9-IT1",0,0,0,0,0.0658511970509621,0,0,0,0,0.0649057258611127,0.0633769050400509,0.406802883256115,0,0,0,0,0,0,0,0,0,0,0.0665292969742741,0,0,0,0,0,100874355,"ARHGEF9 intronic transcript 1","non_coding"]
["ARID1A",11.0020247871126,12.8512391882248,9.36037398148708,9.04464292180922,11.6210698879464,11.0117834154662,8.9392624715388,8.81721103404868,11.5618270779548,15.6710136482816,10.0400225599224,11.1825434807808,11.1667126878839,10.151208408289,10.9755827630417,11.3236879968743,8.09314782533603,8.52571590970439,6.04359119246564,8.94817797320443,8.5844959924238,7.88808960681981,6.42768216491416,7.38435335206466,8.37663731489733,6.96430159935574,5.751150689752,6.66940271836898,8289,"AT-rich interaction domain 1A","protein_coding","hsa03082,hsa04714,hsa05225","ATP-dependent chromatin remodeling|Thermogenesis|Hepatocellular carcinoma","GO:0000785,GO:0003677,GO:0003713,GO:0005515,GO:0005634,GO:0005654,GO:0006337,GO:0006338,GO:0006357,GO:0007399,GO:0016514,GO:0016922,GO:0030071,GO:0030520,GO:0030521,GO:0031491,GO:0035060,GO:0042921,GO:0045582,GO:0045597,GO:0045663,GO:0045815,GO:0045893,GO:0070316,GO:0071564,GO:0071565,GO:0140092,GO:1902459,GO:2000045,GO:2000781,GO:2000819","chromatin|DNA binding|transcription coactivator activity|protein binding|nucleus|nucleoplasm|nucleosome disassembly|chromatin remodeling|regulation of transcription by RNA polymerase II|nervous system development|SWI/SNF complex|nuclear receptor binding|regulation of mitotic metaphase/anaphase transition|intracellular estrogen receptor signaling pathway|androgen receptor signaling pathway|nucleosome binding|brahma complex|glucocorticoid receptor signaling pathway|positive regulation of T cell differentiation|positive regulation of cell differentiation|positive regulation of myoblast differentiation|transcription initiation-coupled chromatin remodeling|positive regulation of DNA-templated transcription|regulation of G0 to G1 transition|npBAF complex|nBAF complex|bBAF complex|positive regulation of stem cell population maintenance|regulation of G1/S transition of mitotic cell cycle|positive regulation of double-strand break repair|regulation of nucleotide-excision repair","WP3651,WP4204,WP4321,WP5351,WP2263","Pathways affected in adenoid cystic carcinoma|Tumor suppressor activity of SMARCB1|Thermogenesis|Kleefstra syndrome|Androgen receptor network in prostate cancer","R-HSA-212436,R-HSA-3214858,R-HSA-3247509,R-HSA-4839726,R-HSA-73857,R-HSA-74160,R-HSA-8878171,R-HSA-8939243","Generic Transcription Pathway|RMTs methylate histone arginines|Chromatin modifying enzymes|Chromatin organization|RNA Polymerase II Transcription|Gene expression (Transcription)|Transcriptional regulation by RUNX1|RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known","chromosome_remodelling_factor"]
["ARID1B",5.72777686538241,6.59550669286362,5.15722074235206,4.35237882491772,6.00624663565515,6.08893809664144,5.23677216493116,4.485331927268,6.68106714038141,7.63515411301741,5.6387550035634,6.02028774131467,6.98580966271782,6.23203700772017,6.7069158954943,6.90594738692666,4.51276702435549,5.02287619798653,4.19207064341341,5.5700974205533,5.30902810730543,4.5343981597269,4.900790691694,5.09311709405214,5.37490366917353,4.17335457677014,4.22474717957534,4.3384213553888,57492,"AT-rich interaction domain 1B","protein_coding","hsa03082,hsa04714,hsa05225","ATP-dependent chromatin remodeling|Thermogenesis|Hepatocellular carcinoma","GO:0000785,GO:0002931,GO:0003677,GO:0003713,GO:0005515,GO:0005654,GO:0005829,GO:0005886,GO:0006338,GO:0006357,GO:0007399,GO:0016514,GO:0030071,GO:0031491,GO:0035060,GO:0045582,GO:0045597,GO:0045663,GO:0045815,GO:0045893,GO:0070316,GO:0071564,GO:0071565,GO:0140092,GO:1904385,GO:2000045,GO:2000781,GO:2000819","chromatin|response to ischemia|DNA binding|transcription coactivator activity|protein binding|nucleoplasm|cytosol|plasma membrane|chromatin remodeling|regulation of transcription by RNA polymerase II|nervous system development|SWI/SNF complex|regulation of mitotic metaphase/anaphase transition|nucleosome binding|brahma complex|positive regulation of T cell differentiation|positive regulation of cell differentiation|positive regulation of myoblast differentiation|transcription initiation-coupled chromatin remodeling|positive regulation of DNA-templated transcription|regulation of G0 to G1 transition|npBAF complex|nBAF complex|bBAF complex|cellular response to angiotensin|regulation of G1/S transition of mitotic cell cycle|positive regulation of double-strand break repair|regulation of nucleotide-excision repair","WP4204,WP4321,WP5351,WP2263","Tumor suppressor activity of SMARCB1|Thermogenesis|Kleefstra syndrome|Androgen receptor network in prostate cancer","R-HSA-212436,R-HSA-3214858,R-HSA-3247509,R-HSA-4839726,R-HSA-73857,R-HSA-74160,R-HSA-8878171,R-HSA-8939243","Generic Transcription Pathway|RMTs methylate histone arginines|Chromatin modifying enzymes|Chromatin organization|RNA Polymerase II Transcription|Gene expression (Transcription)|Transcriptional regulation by RUNX1|RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known","ARID"]
["ARID2",2.45879299571607,2.11776125331097,1.64278977316026,1.34832702263771,2.33777277051652,1.92930385399081,1.68885766417124,1.4821514818846,2.26685852545972,1.64461738499786,1.57466960480036,2.26128071647682,2.56781576937917,1.63084373114159,2.4409784620719,2.1739816371384,1.86217852434522,1.71395241793408,1.57818087334029,2.07431368711788,2.03598310727827,1.76650158700971,2.46311040168885,2.3049075198099,2.41975817914202,1.54224175832717,1.86259115209559,1.55143288280159,196528,"AT-rich interaction domain 2","protein_coding","hsa03082,hsa05225","ATP-dependent chromatin remodeling|Hepatocellular carcinoma","GO:0000776,GO:0000785,GO:0003007,GO:0003677,GO:0005515,GO:0005654,GO:0005886,GO:0006337,GO:0006338,GO:0006357,GO:0008285,GO:0016363,GO:0016514,GO:0016586,GO:0030071,GO:0030336,GO:0042592,GO:0045582,GO:0045597,GO:0045663,GO:0046872,GO:0048568,GO:0060038,GO:0060982,GO:0070316,GO:1905168,GO:2000045,GO:2000781,GO:2000819","kinetochore|chromatin|heart morphogenesis|DNA binding|protein binding|nucleoplasm|plasma membrane|nucleosome disassembly|chromatin remodeling|regulation of transcription by RNA polymerase II|negative regulation of cell population proliferation|nuclear matrix|SWI/SNF complex|RSC-type complex|regulation of mitotic metaphase/anaphase transition|negative regulation of cell migration|homeostatic process|positive regulation of T cell differentiation|positive regulation of cell differentiation|positive regulation of myoblast differentiation|metal ion binding|embryonic organ development|cardiac muscle cell proliferation|coronary artery morphogenesis|regulation of G0 to G1 transition|positive regulation of double-strand break repair via homologous recombination|regulation of G1/S transition of mitotic cell cycle|positive regulation of double-strand break repair|regulation of nucleotide-excision repair",null,null,"R-HSA-212436,R-HSA-3214858,R-HSA-3247509,R-HSA-4839726,R-HSA-73857,R-HSA-74160,R-HSA-8878171,R-HSA-8939243","Generic Transcription Pathway|RMTs methylate histone arginines|Chromatin modifying enzymes|Chromatin organization|RNA Polymerase II Transcription|Gene expression (Transcription)|Transcriptional regulation by RUNX1|RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known","RFX"]
["ARID3A",4.26088031152038,4.37395654516962,3.60058480346244,4.2483408030199,4.13486345539873,4.26310447837782,3.60898574171909,3.91549360307708,5.00940816412031,5.56006571978381,4.51447198324773,4.89234236727345,4.59303201153284,4.96494499944591,3.98989955650775,4.79854201828666,3.87428337167441,4.35672154116481,3.49026559263436,4.43615207387333,4.93612045976421,4.84898540289473,3.39122788116654,3.9117785330324,4.42081640878447,4.39383237197578,2.94411075744158,4.18513260793773,1820,"AT-rich interaction domain 3A","protein_coding",null,null,"GO:0003677,GO:0003682,GO:0003712,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006357,GO:0042802,GO:0045121,GO:0045944","DNA binding|chromatin binding|transcription coregulator activity|protein binding|nucleus|nucleoplasm|cytosol|regulation of transcription by RNA polymerase II|identical protein binding|membrane raft|positive regulation of transcription by RNA polymerase II",null,null,"R-HSA-212436,R-HSA-3700989,R-HSA-6791312,R-HSA-6804116,R-HSA-73857,R-HSA-74160","Generic Transcription Pathway|Transcriptional Regulation by TP53|TP53 Regulates Transcription of Cell Cycle Genes|TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest|RNA Polymerase II Transcription|Gene expression (Transcription)","ARID"]
["ARL15",2.08331968161574,1.51282117501259,2.07507148746935,1.31053241255813,1.8387259453565,1.65482806560185,1.28884556668211,1.52301982519885,1.8852323837068,1.41677872516777,1.4887428109131,1.67529165219046,2.25106193104527,1.58752841583406,2.38191450874139,2.76117696160312,1.57223606984336,1.72035110970522,1.48376854252935,1.7376852396197,2.17777978832349,1.51891841723271,2.71277354975433,1.93321421836115,1.79153858359844,1.55382338106307,1.90037785204161,1.37590703780131,54622,"ADP ribosylation factor like GTPase 15","protein_coding",null,null,"GO:0003674,GO:0003924,GO:0005515,GO:0005525,GO:0008150,GO:0070062","molecular_function|GTPase activity|protein binding|GTP binding|biological_process|extracellular exosome"]
["ARL6IP4",104.240959567934,88.2963908479822,127.920332570019,124.223119554424,85.5743288267478,101.35627442241,126.631619840812,124.102273775642,118.365191828223,122.59029266231,161.430178677871,138.100619911252,108.771535852337,129.189002233722,125.488782211288,107.529519120541,138.377784608344,160.167622119867,168.643728651953,125.041391512647,134.310734390279,149.097551488095,135.771860546194,140.892692696645,136.546093768807,158.421939193988,157.33999131371,169.642313246328,51329,"ADP ribosylation factor like GTPase 6 interacting protein 4","protein_coding",null,null,"GO:0003723,GO:0005515,GO:0005634,GO:0005730,GO:0006397,GO:0008380,GO:0016607","RNA binding|protein binding|nucleus|nucleolus|mRNA processing|RNA splicing|nuclear speck"]
["ARNTL2-AS1",0.265251810432896,0.0946119301109687,0,0,0.485986694103041,0.0622712418623502,0,0.162565686470097,0.0667018411488762,0.127735745852128,0,0.0333581700087015,0.0315315149757817,0,0.0308353374879649,0,0,0,0,0.0637679415594434,0.125179188284993,0.0315164527721838,0.130930965755029,0.161964847833177,0.131488402036948,0.283541546056599,0.0962547394647372,0,101928646,"ARNTL2 antisense RNA 1","non_coding"]
["ARSG",2.76305126495045,1.80179862341871,1.41921996196186,2.26492055873706,2.62945093983597,2.23534196639179,2.07168505068722,2.59564914989085,1.7508360240832,1.1478383165665,1.04116567674871,1.73859521950063,1.23776329205978,1.51894370291924,1.04126575774804,1.39167173911166,1.27548492180221,0.623903648940246,0.921756354534328,1.07366072074849,0.840688573051158,0.754227766638478,1.14558882515329,1.47380662337888,1.5888870333751,1.07578642591674,1.44765112348902,0.975938240397937,22901,"arylsulfatase G","protein_coding","hsa04142","Lysosome","GO:0004065,GO:0005615,GO:0005764,GO:0005783,GO:0005788,GO:0006790,GO:0033889,GO:0046872","arylsulfatase activity|extracellular space|lysosome|endoplasmic reticulum|endoplasmic reticulum lumen|sulfur compound metabolic process|N-sulfoglucosamine-3-sulfatase activity|metal ion binding",null,null,"R-HSA-1430728,R-HSA-163841,R-HSA-1660662,R-HSA-1663150,R-HSA-392499,R-HSA-428157,R-HSA-556833,R-HSA-597592","Metabolism|Gamma carboxylation, hypusine formation and arylsulfatase activation|Glycosphingolipid metabolism|The activation of arylsulfatases|Metabolism of proteins|Sphingolipid metabolism|Metabolism of lipids|Post-translational protein modification"]
["ASAP1-IT1",0,0,0,0,0,0.0429402202155137,0,0,0,0.0220206024974088,0,0,0,0,0,0.0216781906252306,0.0219819915962159,0,0,0,0.0863194911583546,0,0,0,0,0,0,0,29065,"ASAP1 intronic transcript 1","non_coding"]
["ASCC3",6.98984262678885,5.6261781475518,4.03964102789407,3.97203371273207,6.78466878706882,4.75548813814375,4.04791805129522,3.97340872956708,5.8217901526911,3.99751639607118,3.81406998965112,4.85344747744426,6.40537330536734,3.83749777241042,4.57135107738246,4.8610230775076,5.89878593267475,4.39561537644654,4.00821407022597,5.31938540252563,5.57446059625171,4.69616509132378,5.08430964383408,6.11834482754056,6.01881213668124,4.08334622089825,4.78260299678694,3.91210632649432,10973,"activating signal cointegrator 1 complex subunit 3","protein_coding",null,null,"GO:0003723,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005829,GO:0006307,GO:0008283,GO:0016020,GO:0016607,GO:0016887,GO:0022626,GO:0032508,GO:0032790,GO:0043138,GO:0072344,GO:0099053,GO:1990116,GO:1990391","RNA binding|protein binding|ATP binding|nucleus|nucleoplasm|cytosol|DNA dealkylation involved in DNA repair|cell population proliferation|membrane|nuclear speck|ATP hydrolysis activity|cytosolic ribosome|DNA duplex unwinding|ribosome disassembly|3'-5' DNA helicase activity|rescue of stalled ribosome|activating signal cointegrator 1 complex|ribosome-associated ubiquitin-dependent protein catabolic process|DNA repair complex","WP2853,WP2857,WP3888","Endoderm differentiation|Mesodermal commitment pathway|VEGFA-VEGFR2 signaling","R-HSA-112126,R-HSA-73894,R-HSA-73942,R-HSA-73943","ALKBH3 mediated reversal of alkylation damage|DNA Repair|DNA Damage Reversal|Reversal of alkylation damage by DNA dioxygenases"]
["ASPHD2",0.359949461598201,0.319546880867372,0.43555865350703,0.245484432389154,0.343911296171196,0.375567653071889,0.156720478643309,0.392183688724596,0.490792938886679,0.631723385235755,0.895175275936624,0.635755247818657,0.547693994249958,0.66345763803676,0.654624149922541,0.712910134786887,0.776733999194598,0.458866904263015,0.517491285207602,0.53843227806349,0.588880789755534,0.547432367796009,0.458005842671561,0.523583811651097,0.43616497752835,0.608029744659453,0.510864175093854,0.586549845128224,57168,"aspartate beta-hydroxylase domain containing 2","protein_coding",null,null,"GO:0016020,GO:0046872,GO:0051213","membrane|metal ion binding|dioxygenase activity"]
["ASTN1",0,0,0,0,0,0.00256492651910481,0,0,0.00549484211713815,0.00263069108769329,0.00256872651900094,0,0,0.00520811653391353,0.00254018941916258,0.00517956971266529,0,0,0,0,0.00257803931694447,0.0129814956448401,0,0,2.70797626041238E-3,0,0,0,460,"astrotactin 1","protein_coding",null,null,"GO:0001764,GO:0005575,GO:0005768,GO:0007158,GO:0007626,GO:0009897,GO:0030136,GO:0043204","neuron migration|cellular_component|endosome|neuron cell-cell adhesion|locomotory behavior|external side of plasma membrane|clathrin-coated vesicle|perikaryon","WP2858","Ectoderm differentiation"]
["ATG2A",5.33389836893204,5.7913215921703,6.83257866945545,5.9242966766721,5.78064942671671,6.2085392449753,5.57837726139182,5.78858953043218,5.280353752798,7.34237774796757,7.10598553616588,5.66753899609124,5.17273689365722,5.78066801042164,5.65457290202812,5.76897241922931,4.66607227808874,5.41904163871744,4.79720469251007,5.10891631273758,4.61255350413484,5.29451264400134,4.179284477533,4.44897903930682,4.11347058197805,4.57937559391364,4.04352715241503,5.41484734517355,23130,"autophagy related 2A","protein_coding","hsa04140,hsa04136,hsa05010,hsa05014,hsa05016,hsa05017,hsa05022","Autophagy - animal|Autophagy - other|Alzheimer disease|Amyotrophic lateral sclerosis|Huntington disease|Spinocerebellar ataxia|Pathways of neurodegeneration - multiple diseases","GO:0000045,GO:0000407,GO:0000422,GO:0005515,GO:0005789,GO:0005811,GO:0032266,GO:0034045,GO:0034727,GO:0044232,GO:0044805,GO:0061709,GO:0120009,GO:0120013,GO:2000786","autophagosome assembly|phagophore assembly site|autophagy of mitochondrion|protein binding|endoplasmic reticulum membrane|lipid droplet|phosphatidylinositol-3-phosphate binding|phagophore assembly site membrane|piecemeal microautophagy of the nucleus|organelle membrane contact site|late nucleophagy|reticulophagy|intermembrane lipid transfer|lipid transfer activity|positive regulation of autophagosome assembly","WP5124,WP2059,WP4577","Alzheimer's disease|Alzheimer's disease and miRNA effects|Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway"]
["ATOX1-AS1",0.0420862064562734,0,0,0,0.0205624346763347,0.0395210926105314,0,0,0,0,0,0.0211711102397145,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.0407260490163057,0,105378235,null,"non_coding"]
["ATP2C2-AS1",0.206802184926815,0.290778627098888,0.40518948144336,0.284568084201945,0.272366525494306,0.388395580915306,0.117444521464966,0.0881693816545624,0.244191480163272,0.138557920450674,0.0845589126618424,0.0904609480222627,0.0940581515771902,0.171443969557013,0.0418097554665035,0.0767269115157845,0.164249030602679,0.249582754207056,0.216061118888259,0.121048484127682,0.0763789293430037,0.119653190611406,0.150900340035044,0.11419656282514,0.169371359761903,0.0939779129191374,0.139212992101101,0.177512070182362,105371374,"ATP2C2 antisense RNA 1","non_coding"]
["ATP6V0A2",2.70050194873286,2.74657234047246,2.48569044380545,2.04776767126447,2.78585933208958,2.19600549106836,2.64855672251566,2.28119784469849,3.02315427543247,2.56175888431911,2.40962282288666,2.77421398961623,2.8698340801268,2.6405139040317,3.07501541703118,2.63375297952645,2.59245884806205,2.3368672767402,2.42820259876423,2.58512714381819,2.33390817313011,2.40456079308306,2.55356867082911,2.49130184513608,2.39509060382043,2.40365771909034,2.3416710116161,1.89261780664517,23545,"ATPase H+ transporting V0 subunit a2","protein_coding","hsa00190,hsa04145,hsa04142,hsa04966,hsa04721,hsa05165,hsa05110,hsa05120,hsa05152,hsa05323","Oxidative phosphorylation|Phagosome|Lysosome|Collecting duct acid secretion|Synaptic vesicle cycle|Human papillomavirus infection|Vibrio cholerae infection|Epithelial cell signaling in Helicobacter pylori infection|Tuberculosis|Rheumatoid arthritis","GO:0000139,GO:0000220,GO:0001669,GO:0005515,GO:0005765,GO:0005886,GO:0005925,GO:0006879,GO:0006955,GO:0007035,GO:0010008,GO:0016241,GO:0016471,GO:0030670,GO:0033176,GO:0036295,GO:0043231,GO:0046961,GO:0048471,GO:0051117,GO:0061795,GO:1902495,GO:1902600","Golgi membrane|vacuolar proton-transporting V-type ATPase, V0 domain|acrosomal vesicle|protein binding|lysosomal membrane|plasma membrane|focal adhesion|intracellular iron ion homeostasis|immune response|vacuolar acidification|endosome membrane|regulation of macroautophagy|vacuolar proton-transporting V-type ATPase complex|phagocytic vesicle membrane|proton-transporting V-type ATPase complex|cellular response to increased oxygen levels|intracellular membrane-bounded organelle|proton-transporting ATPase activity, rotational mechanism|perinuclear region of cytoplasm|ATPase binding|Golgi lumen acidification|transmembrane transporter complex|proton transmembrane transport",null,null,"R-HSA-1222556,R-HSA-162582,R-HSA-168249,R-HSA-168256,R-HSA-382551,R-HSA-74752,R-HSA-77387,R-HSA-9006934,R-HSA-917937,R-HSA-917977,R-HSA-983712","ROS and RNS production in phagocytes|Signal Transduction|Innate Immune System|Immune System|Transport of small molecules|Signaling by Insulin receptor|Insulin receptor recycling|Signaling by Receptor Tyrosine Kinases|Iron uptake and transport|Transferrin endocytosis and recycling|Ion channel transport"]
["ATP6V1G2-DDX39B",0.10525203345648,0.0222471436529913,0.142731876805617,0.0672952172303239,0.102847856565494,0.0988370231468149,0.0218220437156472,0.103209815869995,0.0823427717957168,0.0563173326343711,0.0439926455809464,0.0705948604349007,0.0111215278417833,0.055747182291966,0.0761318462663811,0.0665299438103607,0.11243717176546,0.108206666249133,0.0216169275630569,0.0449833722237115,0,0.022232430458816,0.0115452142254705,0.0228507455598044,0.0579718388590235,0.100008363099355,0.0452668709673645,0.0439773731149033,100532737,"ATP6V1G2-DDX39B readthrough (NMD candidate)","non_coding"]
["ATRAID",69.8965178964092,66.612028603304,79.0835405979809,76.5926738788592,67.4868405670879,79.8830510809271,86.2643560061381,88.559694151986,81.7127241899658,79.6015377323223,87.6630442434817,88.427791134208,81.2300266150903,83.6477465900415,82.8199091143193,78.4371560258815,109.732303091352,92.0674050575207,114.319561832718,88.81846556224,100.254713376797,101.25910477483,111.050912652248,111.127046996849,98.3242755091892,106.093661000795,124.826158849027,116.121851189078,51374,"all-trans retinoic acid induced differentiation factor","protein_coding",null,null,"GO:0003674,GO:0005515,GO:0005635,GO:0005765,GO:0005886,GO:0006855,GO:0010468,GO:0030154,GO:0030501,GO:0033689,GO:0042177,GO:0042910,GO:0043231,GO:0045669,GO:0048471","molecular_function|protein binding|nuclear envelope|lysosomal membrane|plasma membrane|xenobiotic transmembrane transport|regulation of gene expression|cell differentiation|positive regulation of bone mineralization|negative regulation of osteoblast proliferation|negative regulation of protein catabolic process|xenobiotic transmembrane transporter activity|intracellular membrane-bounded organelle|positive regulation of osteoblast differentiation|perinuclear region of cytoplasm"]
["AURKB",17.2093351501834,15.5142718685523,4.7326379429913,16.3879061914534,12.5005662198436,10.2254128639477,3.32490274545442,9.99084623435328,10.0185034865931,13.3771801096801,6.45943145153965,10.5416340369192,7.79191833972716,3.60082703789598,2.19531923929147,2.54141879519652,18.7859963061905,18.4596293261339,8.17782414606883,15.8751911731087,18.5285885053075,18.616394728513,8.11882946126735,14.7448954233647,17.0164378325927,21.3733190236227,8.90133377092997,18.0543577094129,9212,"aurora kinase B","protein_coding","hsa03083,hsa04110","Polycomb repressive complex|Cell cycle","GO:0000122,GO:0000278,GO:0000281,GO:0000776,GO:0000779,GO:0001934,GO:0002903,GO:0004674,GO:0004712,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005819,GO:0005829,GO:0005876,GO:0006468,GO:0007051,GO:0007052,GO:0008608,GO:0009838,GO:0010369,GO:0015630,GO:0016570,GO:0019900,GO:0030496,GO:0031616,GO:0032091,GO:0032133,GO:0032212,GO:0032465,GO:0032466,GO:0032467,GO:0034501,GO:0034644,GO:0036089,GO:0043687,GO:0044839,GO:0044878,GO:0045824,GO:0046777,GO:0051233,GO:0051256,GO:0051973,GO:0051983,GO:0062033,GO:0090267,GO:0097431,GO:0106310,GO:1901796,GO:1901970,GO:1902425,GO:1903490,GO:1904355,GO:1905116,GO:1990023","negative regulation of transcription by RNA polymerase II|mitotic cell cycle|mitotic cytokinesis|kinetochore|condensed chromosome, centromeric region|positive regulation of protein phosphorylation|negative regulation of B cell apoptotic process|protein serine/threonine kinase activity|protein serine/threonine/tyrosine kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|spindle|cytosol|spindle microtubule|protein phosphorylation|spindle organization|mitotic spindle organization|attachment of spindle microtubules to kinetochore|abscission|chromocenter|microtubule cytoskeleton|histone modification|kinase binding|midbody|spindle pole centrosome|negative regulation of protein binding|chromosome passenger complex|positive regulation of telomere maintenance via telomerase|regulation of cytokinesis|negative regulation of cytokinesis|positive regulation of cytokinesis|protein localization to kinetochore|cellular response to UV|cleavage furrow formation|post-translational protein modification|cell cycle G2/M phase transition|mitotic cytokinesis checkpoint signaling|negative regulation of innate immune response|protein autophosphorylation|spindle midzone|mitotic spindle midzone assembly|positive regulation of telomerase activity|regulation of chromosome segregation|positive regulation of mitotic sister chromatid segregation|positive regulation of mitotic cell cycle spindle assembly checkpoint|mitotic spindle pole|protein serine kinase activity|regulation of signal transduction by p53 class mediator|positive regulation of mitotic sister chromatid separation|positive regulation of attachment of mitotic spindle microtubules to kinetochore|positive regulation of mitotic cytokinesis|positive regulation of telomere capping|positive regulation of lateral attachment of mitotic spindle microtubules to kinetochore|mitotic spindle midzone","WP5117,WP2038,WP3878","Cohesin complex - Cornelia de Lange syndrome|Microtubule cytoskeleton regulation|ATM signaling in development and disease ","R-HSA-141424,R-HSA-141444,R-HSA-162582,R-HSA-1640170,R-HSA-174143,R-HSA-174178,R-HSA-194315,R-HSA-195258,R-HSA-212436,R-HSA-212436,R-HSA-2467813,R-HSA-2500257,R-HSA-2555396,R-HSA-2990846,R-HSA-3108232,R-HSA-3700989,R-HSA-392499,R-HSA-453276,R-HSA-4615885,R-HSA-5633007,R-HSA-5663220,R-HSA-597592,R-HSA-6804756,R-HSA-68877,R-HSA-68882,R-HSA-68886,R-HSA-69278,R-HSA-69618,R-HSA-69620,R-HSA-73857,R-HSA-73857,R-HSA-74160,R-HSA-74160,R-HSA-8986944,R-HSA-9022692,R-HSA-9648025,R-HSA-9716542","Amplification of signal from the kinetochores|Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal|Signal Transduction|Cell Cycle|APC/C-mediated degradation of cell cycle proteins|APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1|Signaling by Rho GTPases|RHO GTPase Effectors|Generic Transcription Pathway|Generic Transcription Pathway|Separation of Sister Chromatids|Resolution of Sister Chromatid Cohesion|Mitotic Metaphase and Anaphase|SUMOylation|SUMO E3 ligases SUMOylate target proteins|Transcriptional Regulation by TP53|Metabolism of proteins|Regulation of mitotic cell cycle|SUMOylation of DNA replication proteins|Regulation of TP53 Activity|RHO GTPases Activate Formins|Post-translational protein modification|Regulation of TP53 Activity through Phosphorylation|Mitotic Prometaphase|Mitotic Anaphase|M Phase|Cell Cycle, Mitotic|Mitotic Spindle Checkpoint|Cell Cycle Checkpoints|RNA Polymerase II Transcription|RNA Polymerase II Transcription|Gene expression (Transcription)|Gene expression (Transcription)|Transcriptional Regulation by MECP2|Regulation of MECP2 expression and activity|EML4 and NUDC in mitotic spindle formation|Signaling by Rho GTPases, Miro GTPases and RHOBTB3"]
["AXIN1",5.5145623862543,6.2290463272672,6.2229927639983,6.11381786471682,5.46634175851926,6.64934181506596,6.42549694788094,5.44657125116809,5.77698112584505,7.84951003035334,7.66929527878129,6.30853392099811,5.03150146883055,5.75049513141327,5.94703936169381,5.66711331305489,4.96248022125664,5.63613812926966,5.96067537249599,5.48940696255543,5.51469051323314,6.1493012010745,5.1151837260427,4.96006814740559,5.23555964070807,6.26983706377888,4.94176910599654,5.68920251804695,8312,"axin 1","protein_coding","hsa04310,hsa04390,hsa04550,hsa05200,hsa05210,hsa05225,hsa05226,hsa05217,hsa05213,hsa05224,hsa05165,hsa05010,hsa05022,hsa04934","Wnt signaling pathway|Hippo signaling pathway|Signaling pathways regulating pluripotency of stem cells|Pathways in cancer|Colorectal cancer|Hepatocellular carcinoma|Gastric cancer|Basal cell carcinoma|Endometrial cancer|Breast cancer|Human papillomavirus infection|Alzheimer disease|Pathways of neurodegeneration - multiple diseases|Cushing syndrome","GO:0001701,GO:0001934,GO:0002039,GO:0005515,GO:0005634,GO:0005730,GO:0005737,GO:0005829,GO:0005886,GO:0005938,GO:0006913,GO:0006915,GO:0007605,GO:0008013,GO:0009950,GO:0010629,GO:0010800,GO:0015630,GO:0016328,GO:0019899,GO:0019901,GO:0030511,GO:0030877,GO:0031122,GO:0031398,GO:0031410,GO:0031625,GO:0032147,GO:0032436,GO:0033138,GO:0034244,GO:0035591,GO:0036342,GO:0042802,GO:0042803,GO:0043161,GO:0043621,GO:0045599,GO:0045732,GO:0045860,GO:0046330,GO:0046332,GO:0048320,GO:0048468,GO:0048471,GO:0051248,GO:0060070,GO:0060090,GO:0060322,GO:0065003,GO:0070016,GO:0070411,GO:0070412,GO:0071514,GO:0071944,GO:0090090,GO:1990756,GO:1990909,GO:2000060","in utero embryonic development|positive regulation of protein phosphorylation|p53 binding|protein binding|nucleus|nucleolus|cytoplasm|cytosol|plasma membrane|cell cortex|nucleocytoplasmic transport|apoptotic process|sensory perception of sound|beta-catenin binding|dorsal/ventral axis specification|negative regulation of gene expression|positive regulation of peptidyl-threonine phosphorylation|microtubule cytoskeleton|lateral plasma membrane|enzyme binding|protein kinase binding|positive regulation of transforming growth factor beta receptor signaling pathway|beta-catenin destruction complex|cytoplasmic microtubule organization|positive regulation of protein ubiquitination|cytoplasmic vesicle|ubiquitin protein ligase binding|activation of protein kinase activity|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of peptidyl-serine phosphorylation|negative regulation of transcription elongation by RNA polymerase II|signaling adaptor activity|post-anal tail morphogenesis|identical protein binding|protein homodimerization activity|proteasome-mediated ubiquitin-dependent protein catabolic process|protein self-association|negative regulation of fat cell differentiation|positive regulation of protein catabolic process|positive regulation of protein kinase activity|positive regulation of JNK cascade|SMAD binding|axial mesoderm formation|cell development|perinuclear region of cytoplasm|negative regulation of protein metabolic process|canonical Wnt signaling pathway|molecular adaptor activity|head development|protein-containing complex assembly|armadillo repeat domain binding|I-SMAD binding|R-SMAD binding|genomic imprinting|cell periphery|negative regulation of canonical Wnt signaling pathway|ubiquitin ligase-substrate adaptor activity|Wnt signalosome|positive regulation of ubiquitin-dependent protein catabolic process","WP2064,WP3664,WP4216,WP428,WP5124,WP4262,WP2864,WP399,WP2870,WP2857,WP2059,WP5346,WP4844,WP4258,WP363,WP710,WP4879,WP3680,WP4336,WP4872,WP4155,WP5087,WP3931","Neural crest differentiation|Regulation of Wnt / B-catenin signaling by small molecule compounds|Chromosomal and microsatellite instability in colorectal cancer |Wnt signaling|Alzheimer's disease|Breast cancer pathway|Apoptosis-related network due to altered Notch3 in ovarian cancer|Wnt signaling pathway and pluripotency|Extracellular vesicle-mediated signaling in recipient cells|Mesodermal commitment pathway|Alzheimer's disease and miRNA effects|8p23.1 copy number variation syndrome|Influence of laminopathies on Wnt signaling|lncRNA in canonical Wnt signaling and colorectal cancer|Wnt signaling pathway|DNA damage response (only ATM dependent)|Overlap between signal transduction pathways contributing to LMNA laminopathies|Physico-chemical features and toxicity-associated pathways|ncRNAs involved in Wnt signaling in hepatocellular carcinoma|MAP3K1 role in promoting and blocking gonadal determination|Endometrial cancer|Pleural mesothelioma|Embryonic stem cell pluripotency pathways","R-HSA-162582,R-HSA-162582,R-HSA-1643685,R-HSA-195253,R-HSA-195721,R-HSA-195721,R-HSA-196299,R-HSA-201681,R-HSA-201681,R-HSA-212436,R-HSA-392499,R-HSA-4641257,R-HSA-4641262,R-HSA-4641262,R-HSA-4791275,R-HSA-4839735,R-HSA-4839743,R-HSA-4839744,R-HSA-4839748,R-HSA-5339716,R-HSA-5358747,R-HSA-5358749,R-HSA-5358751,R-HSA-5358752,R-HSA-5467337,R-HSA-5467340,R-HSA-5467348,R-HSA-5663202,R-HSA-5688426,R-HSA-5689880,R-HSA-597592,R-HSA-73857,R-HSA-74160,R-HSA-8878171,R-HSA-8931987,R-HSA-8939211,R-HSA-8939256,R-HSA-9006931,R-HSA-9018519","Signal Transduction|Signal Transduction|Disease|Degradation of beta-catenin by the destruction complex|Signaling by WNT|Signaling by WNT|Beta-catenin phosphorylation cascade|TCF dependent signaling in response to WNT|TCF dependent signaling in response to WNT|Generic Transcription Pathway|Metabolism of proteins|Degradation of AXIN|Disassembly of the destruction complex and recruitment of AXIN to the membrane|Disassembly of the destruction complex and recruitment of AXIN to the membrane|Signaling by WNT in cancer|Signaling by AXIN mutants|Signaling by CTNNB1 phospho-site mutants|Signaling by APC mutants|Signaling by AMER1 mutants|Signaling by GSK3beta mutants|CTNNB1 S33 mutants aren't phosphorylated|CTNNB1 S37 mutants aren't phosphorylated|CTNNB1 S45 mutants aren't phosphorylated|CTNNB1 T41 mutants aren't phosphorylated|APC truncation mutants have impaired AXIN binding|AXIN missense mutants destabilize the destruction complex|Truncations of AMER1 destabilize the destruction complex|Diseases of signal transduction by growth factor receptors and second messengers|Deubiquitination|Ub-specific processing proteases|Post-translational protein modification|RNA Polymerase II Transcription|Gene expression (Transcription)|Transcriptional regulation by RUNX1|RUNX1 regulates estrogen receptor mediated transcription|ESR-mediated signaling|RUNX1 regulates transcription of genes involved in WNT signaling|Signaling by Nuclear Receptors|Estrogen-dependent gene expression"]
["B3GNT5",0.240244781375234,0.27135876793838,0.151541674821256,0.187207091334229,0.315454836172273,0.380703531575115,0.182118796808068,0.231902294814424,0.789150309322769,0.473619277972748,0.564840819184411,0.883738334326054,1.04596722613368,0.518927781688688,0.973999038627298,1.06064041925216,0.357298432126712,0.336908334122161,0.381630133937688,0.476487983316615,0.354305389485099,0.435314146311353,0.63370058669271,0.458422995712202,0.327503350345755,0.221142136974561,0.403208302163871,0.331728778471177,84002,"UDP-GlcNAc:betaGal beta-1%2C3-N-acetylglucosaminyltransferase 5","protein_coding","hsa00601","Glycosphingolipid biosynthesis - lacto and neolacto series","GO:0000139,GO:0005515,GO:0006486,GO:0006493,GO:0007417,GO:0008457,GO:0008499,GO:0009247,GO:0016020,GO:0016266,GO:0047256","Golgi membrane|protein binding|protein glycosylation|protein O-linked glycosylation|central nervous system development|beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity|UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity|glycolipid biosynthetic process|membrane|O-glycan processing|lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity","WP5303,WP5302,WP2882,WP5194,WP5292,WP2880","Lacto series sphingolipid metabolism|Neolacto series sphingolipid metabolism|Nuclear receptors meta-pathway|Synthesis of ceramides and 1-deoxyceramides|Glycosphingolipid metabolism|Glucocorticoid receptor pathway","R-HSA-392499,R-HSA-5173105,R-HSA-597592,R-HSA-913709","Metabolism of proteins|O-linked glycosylation|Post-translational protein modification|O-linked glycosylation of mucins"]
["BAG4",5.31160114356589,4.55737799924091,4.87818320070913,4.93398046415825,5.54800649921853,4.99389543209758,4.2785400149989,5.17075084323351,6.05339471673005,3.29090742512384,4.40331320221082,4.73650247679664,5.52159875970473,3.82705668283838,4.58137294084055,5.10928145838843,5.44641159330232,4.91463746574735,6.04287638282553,6.5529878500816,5.7468790035599,5.35412493281387,7.78632134233106,6.45680564716396,5.92828007904293,4.9798461860672,6.2027315525742,5.38599700778104,9530,"BAG cochaperone 4","protein_coding","hsa04668","TNF signaling pathway","GO:0000774,GO:0003723,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0006457,GO:0010763,GO:0016020,GO:0030838,GO:0031625,GO:0033138,GO:0043066,GO:0044877,GO:0045785,GO:0050821,GO:0051087,GO:0051496,GO:0051897,GO:0071356,GO:0071364,GO:0072659,GO:0090367,GO:0097178,GO:1903215","adenyl-nucleotide exchange factor activity|RNA binding|protein binding|nucleus|cytoplasm|cytosol|plasma membrane|protein folding|positive regulation of fibroblast migration|membrane|positive regulation of actin filament polymerization|ubiquitin protein ligase binding|positive regulation of peptidyl-serine phosphorylation|negative regulation of apoptotic process|protein-containing complex binding|positive regulation of cell adhesion|protein stabilization|protein-folding chaperone binding|positive regulation of stress fiber assembly|positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction|cellular response to tumor necrosis factor|cellular response to epidermal growth factor stimulus|protein localization to plasma membrane|negative regulation of mRNA modification|ruffle assembly|negative regulation of protein targeting to mitochondrion","WP3941","Oxidative damage response","R-HSA-1226099,R-HSA-162582,R-HSA-1643685,R-HSA-1839124,R-HSA-2262752,R-HSA-3371453,R-HSA-3371556,R-HSA-5655302,R-HSA-5663202,R-HSA-73887,R-HSA-75893,R-HSA-8853336,R-HSA-8953897","Signaling by FGFR in disease|Signal Transduction|Disease|FGFR1 mutant receptor activation|Cellular responses to stress|Regulation of HSF1-mediated heat shock response|Cellular response to heat stress|Signaling by FGFR1 in disease|Diseases of signal transduction by growth factor receptors and second messengers|Death Receptor Signaling|TNF signaling|Signaling by plasma membrane FGFR1 fusions|Cellular responses to stimuli"]
["BAZ1A",7.48244534189399,6.40786007900667,5.73663366248487,5.6571028650342,7.18651034264837,5.75866303530164,5.32223038613625,4.84103586150938,7.09143189629706,4.87802116455367,5.14068643827319,6.320647089544,7.01084915211848,5.24504344396655,6.96273527888432,6.37918899990164,6.29043651069475,5.44960471710599,6.07954859958869,6.13041090220219,6.36691365940038,5.95490737600251,8.39728213200658,7.27135220011408,6.63532763865024,5.03881016342437,7.28758653226989,5.16793514350228,11177,"bromodomain adjacent to zinc finger domain 1A","protein_coding","hsa03082","ATP-dependent chromatin remodeling","GO:0000228,GO:0003677,GO:0004402,GO:0005515,GO:0005634,GO:0005721,GO:0006261,GO:0006275,GO:0006334,GO:0006338,GO:0006355,GO:0006357,GO:0008623,GO:0016590,GO:0031445,GO:0045740,GO:0046872","nuclear chromosome|DNA binding|histone acetyltransferase activity|protein binding|nucleus|pericentric heterochromatin|DNA-templated DNA replication|regulation of DNA replication|nucleosome assembly|chromatin remodeling|regulation of DNA-templated transcription|regulation of transcription by RNA polymerase II|CHRAC|ACF complex|regulation of heterochromatin formation|positive regulation of DNA replication|metal ion binding","WP2858","Ectoderm differentiation"]
["BCAP31",77.0574576901427,61.9786637151679,71.3131166667453,78.2430786932174,64.1507684967743,64.2462215287798,69.5480692284746,72.9150917545373,63.9721739029207,65.0140613878322,79.3626948336582,69.4846751010854,60.5326142652154,67.2702370776297,59.0115244801894,60.7910421158207,77.2668299569676,82.9551240867112,78.9233547780944,71.55500271749,66.1984050566041,78.3654973620929,60.474053155408,66.4398888562541,70.4532867571099,81.3035315943927,67.511193583772,78.9619185572498,10134,"B cell receptor associated protein 31","protein_coding","hsa04141,hsa05165","Protein processing in endoplasmic reticulum|Human papillomavirus infection","GO:0000139,GO:0005515,GO:0005739,GO:0005783,GO:0005789,GO:0005811,GO:0005829,GO:0005886,GO:0006626,GO:0006888,GO:0006915,GO:0007204,GO:0007283,GO:0016020,GO:0030136,GO:0032471,GO:0032580,GO:0033116,GO:0034976,GO:0035584,GO:0042288,GO:0043280,GO:0044233,GO:0044877,GO:0051561,GO:0070973,GO:0097038,GO:0098553,GO:1903071,GO:1904154,GO:2001244","Golgi membrane|protein binding|mitochondrion|endoplasmic reticulum|endoplasmic reticulum membrane|lipid droplet|cytosol|plasma membrane|protein targeting to mitochondrion|endoplasmic reticulum to Golgi vesicle-mediated transport|apoptotic process|positive regulation of cytosolic calcium ion concentration|spermatogenesis|membrane|clathrin-coated vesicle|negative regulation of endoplasmic reticulum calcium ion concentration|Golgi cisterna membrane|endoplasmic reticulum-Golgi intermediate compartment membrane|response to endoplasmic reticulum stress|calcium-mediated signaling using intracellular calcium source|MHC class I protein binding|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|mitochondria-associated endoplasmic reticulum membrane|protein-containing complex binding|positive regulation of mitochondrial calcium ion concentration|protein localization to endoplasmic reticulum exit site|perinuclear endoplasmic reticulum|lumenal side of endoplasmic reticulum membrane|positive regulation of ER-associated ubiquitin-dependent protein catabolic process|positive regulation of retrograde protein transport, ER to cytosol|positive regulation of intrinsic apoptotic signaling pathway",null,null,"R-HSA-109581,R-HSA-111465,R-HSA-1280218,R-HSA-162582,R-HSA-168256,R-HSA-194315,R-HSA-5357801,R-HSA-75153,R-HSA-8980692,R-HSA-9012999,R-HSA-9716542,R-HSA-983169,R-HSA-983170","Apoptosis|Apoptotic cleavage of cellular proteins|Adaptive Immune System|Signal Transduction|Immune System|Signaling by Rho GTPases|Programmed Cell Death|Apoptotic execution phase|RHOA GTPase cycle|RHO GTPase cycle|Signaling by Rho GTPases, Miro GTPases and RHOBTB3|Class I MHC mediated antigen processing & presentation|Antigen Presentation: Folding, assembly and peptide loading of class I MHC"]
["BCAT1",12.7102458131677,12.4892239529835,12.5455954257092,10.5472304793897,15.27947857511,12.5885296684705,11.9779459167561,11.7985101976288,19.5236679605843,10.9432758873919,11.6082338808917,14.2296245126934,24.1929178842719,16.284317447465,18.6183611599333,21.2489374072062,17.0474832369271,15.2120695272066,15.0332663205604,20.9805938017877,19.2964070368251,18.2287766299363,24.8408329294354,20.3694697435329,19.5288446422599,15.2852630225577,17.560648253852,14.5759389444927,586,"branched chain amino acid transaminase 1","protein_coding","hsa00270,hsa00280,hsa00290,hsa00770","Cysteine and methionine metabolism|Valine, leucine and isoleucine degradation|Valine, leucine and isoleucine biosynthesis|Pantothenate and CoA biosynthesis","GO:0000082,GO:0004084,GO:0005739,GO:0005829,GO:0006629,GO:0009082,GO:0009098,GO:0009099,GO:0050048,GO:0052654,GO:0052655,GO:0052656","G1/S transition of mitotic cell cycle|branched-chain-amino-acid transaminase activity|mitochondrion|cytosol|lipid metabolic process|branched-chain amino acid biosynthetic process|leucine biosynthetic process|valine biosynthetic process|L-leucine:2-oxoglutarate aminotransferase activity|L-leucine transaminase activity|L-valine transaminase activity|L-isoleucine transaminase activity","WP4686,WP2525,WP3925","Leucine, isoleucine and valine metabolism|Trans-sulfuration, one-carbon metabolism and related pathways|Amino acid metabolism","R-HSA-1430728,R-HSA-70895,R-HSA-71291","Metabolism|Branched-chain amino acid catabolism|Metabolism of amino acids and derivatives"]
["BCLAF1",18.0658379426169,15.8679734566841,14.4198660542674,14.1060097710043,18.6505309626514,14.8627404879557,13.5255856207893,12.6177971467369,18.0337166976407,11.3320194048152,12.756474319068,14.3444181579015,19.6840515174959,12.1434016583682,15.9828383276387,16.2014543226789,17.4030471728476,14.4784588317156,17.402699208495,20.6994285128315,18.6061358892804,16.5901348216049,26.524854581622,21.2121167757663,18.3226358553683,14.8348857919318,20.5199545932284,13.9762951235832,9774,"BCL2 associated transcription factor 1","protein_coding",null,null,"GO:0003677,GO:0003712,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006915,GO:0006974,GO:0016592,GO:0016607,GO:0043065,GO:0043620,GO:0045892,GO:0045944,GO:1990830,GO:2000144,GO:2001244","DNA binding|transcription coregulator activity|RNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|apoptotic process|DNA damage response|mediator complex|nuclear speck|positive regulation of apoptotic process|regulation of DNA-templated transcription in response to stress|negative regulation of DNA-templated transcription|positive regulation of transcription by RNA polymerase II|cellular response to leukemia inhibitory factor|positive regulation of DNA-templated transcription initiation|positive regulation of intrinsic apoptotic signaling pathway","WP2916","Interactome of polycomb repressive complex 2 (PRC2) "]
["BEST2",0,0,0,0.0128555839313688,0,0.012587399212852,0.0625308438147276,0,0,0.077460836432954,0,0.0134859235291269,0.0254948997268131,0,0,0,0,0,0,0.0515597578198185,0,0,0.0132330774687765,0,0,0,0.0129711757309516,0,54831,"bestrophin 2","protein_coding","hsa04970","Salivary secretion","GO:0003674,GO:0005254,GO:0005515,GO:0005886,GO:0005929,GO:0007608,GO:0008150,GO:0034707,GO:0051899,GO:1902476","molecular_function|chloride channel activity|protein binding|plasma membrane|cilium|sensory perception of smell|biological_process|chloride channel complex|membrane depolarization|chloride transmembrane transport",null,null,"R-HSA-2672351,R-HSA-382551,R-HSA-983712","Stimuli-sensing channels|Transport of small molecules|Ion channel transport"]
["BEX5",0.138237001206374,0.0525945293539949,0.103825475672409,0.0795463978030239,0.0270158757132152,0,0.154768648506359,0.0542219089641801,0.139047684241119,0.0532559801937335,0.156004689329356,0.0556311635222038,0.210339459899984,0.105433645278344,0.128559637834438,0.0786418053758366,0.132906503035582,0.0767434971397698,0.0255523169399211,0.13293163202007,0.130475230866282,0.131399364634797,0.109176282214193,0.135053765423972,0.0822308237354149,0.26270003070543,0.160523288584269,0.0259917551358595,340542,"brain expressed X-linked 5","protein_coding",null,null,"GO:0005102,GO:0005515,GO:0005737,GO:0007165","signaling receptor binding|protein binding|cytoplasm|signal transduction"]
["BIN3-IT1",0,0.0557690768027678,0,0.0140579550222853,0.0286465240025936,0.0275293744611695,0,0.028747341620487,0.0884642689299125,0.0282352260407233,0,0.014747249710209,0.111517658185146,0,0.0136319354963107,0,0,0.0271252164985592,0,0.0140955237867937,0.0415051713196166,0.0278660969046062,0.014470755187444,0.0143205460890019,0.0145323641729254,0.0417834469719077,0.0141843580179139,0.0137802943216221,80094,"BIN3 intronic transcript 1","non_coding"]
["BMPR1B-DT",0,0.0398753235770957,0.0787168264234833,0.0402061886251676,0,0,0,0.0822182911976293,0.0421684267916301,0.04037681235528,0,0,0,0.0399680420475837,0,0,0.0403060156950833,0.0387894814470065,0,0,0,0,0,0,0,0,0,0.0394120703848569,100507012,"BMPR1B divergent transcript","non_coding"]
["BOLA3",39.0986545303976,29.8438417239763,32.0105165873787,35.5880550891727,28.9982568635227,23.2152238682452,34.7114009420344,32.9105005557588,28.1890994457468,21.1908423892497,32.7961209504551,31.8112524924601,25.6813110837345,21.7171937588534,21.5459003840906,17.7758819538715,47.6308170338331,39.7717988555429,55.2586118904808,41.4279634817144,45.7509633853822,43.1664669496205,60.4637430519349,53.2878357141776,46.1307512973359,47.4883555506289,68.8080907282841,50.9578896636554,388962,"bolA family member 3","protein_coding",null,null,"GO:0003674,GO:0005515,GO:0005739,GO:0005759,GO:0005829,GO:0006879,GO:0008150,GO:0016226,GO:0016604,GO:0045454,GO:0106035,GO:1990229","molecular_function|protein binding|mitochondrion|mitochondrial matrix|cytosol|intracellular iron ion homeostasis|biological_process|iron-sulfur cluster assembly|nuclear body|cell redox homeostasis|protein maturation by [4Fe-4S] cluster transfer|iron-sulfur cluster assembly complex"]
["BRD3OS",5.71669119297218,5.89328088286778,6.47161896111453,6.09232729037855,5.46557981859094,5.6845687304734,6.07280362275482,6.1314558354822,5.6022855250474,6.88580984672276,6.47823063133783,6.53423849791883,5.31019679898636,6.50853749413272,5.85475795216974,5.80263585072501,6.18043308070693,5.96983909464594,6.17795392540306,6.40058087754505,5.98677399072558,6.41248324878263,5.46097573192563,5.64530443960712,5.35723251958064,6.31090358875242,5.57325444481903,6.11025817013804,266655,"BRD3 opposite strand","protein_coding"]
["BRI3BP",3.41793581867719,2.59203268183414,1.6144471454399,1.82641129527965,2.54135106056698,1.97514825513257,1.67400846422211,1.75942483367854,1.87981032985522,1.55698459295143,1.11600823953483,1.4548462148872,1.3447711120039,0.961993422221347,1.20934511035242,1.06788875693232,1.9163446552758,1.85410346984576,1.24452615226365,2.00212173335092,1.93159060641898,1.77978854707986,1.41704684210395,1.7841622391518,1.82111956743681,1.46853368291736,1.25835278615387,1.3794951890513,140707,"BRI3 binding protein","protein_coding",null,null,"GO:0005515,GO:0005739,GO:0005741","protein binding|mitochondrion|mitochondrial outer membrane"]
["BSG-AS1",0.550126841535573,0.479656740919724,0.946877743696084,0.131900914724401,0.134390198063188,0.129149284780843,0.641579218935802,0.71927022095341,0,0.176614220030238,0.172454163374288,0,0.305180019944173,0.0874130987639331,0.127903721314875,0.0869339685277105,0.308532953475459,0.339341994155444,0.593178786105312,0.484929167828318,0.216349234854804,0.305034239330779,0.633612352135944,0.268729431200761,0.136352131193927,0.435599540710535,0.177449213571046,0.258591441402684,105372233,null,"non_coding"]
["BTN2A1",13.8206451592848,12.8624134909093,9.29105357316414,11.4694039594719,14.3562885946462,11.15321806856,8.42730254936736,10.0183214946662,11.8269274078071,13.9350083257615,10.4554385883752,11.2001898797033,11.7270059376558,10.3081775981043,10.0068762295024,9.92689860952722,12.650532933275,11.5751241542304,9.38041789762009,11.6361079824198,13.4030861121795,12.4716872085276,10.4094458028256,11.8509679159535,12.7497529259931,10.9953025282688,10.3547498413078,11.7399085714821,11120,"butyrophilin subfamily 2 member A1","protein_coding",null,null,"GO:0001817,GO:0003674,GO:0005102,GO:0005886,GO:0006629,GO:0009897,GO:0050852","regulation of cytokine production|molecular_function|signaling receptor binding|plasma membrane|lipid metabolic process|external side of plasma membrane|T cell receptor signaling pathway",null,null,"R-HSA-1280218,R-HSA-168256,R-HSA-8851680","Adaptive Immune System|Immune System|Butyrophilin (BTN) family interactions"]
["BTNL9",0,0,0,0,0,0,0,0.00436984305175034,0,0,0,0.00448341746025365,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,153579,"butyrophilin like 9","protein_coding",null,null,"GO:0001817,GO:0005102,GO:0005886,GO:0009897,GO:0050852","regulation of cytokine production|signaling receptor binding|plasma membrane|external side of plasma membrane|T cell receptor signaling pathway",null,null,"R-HSA-1280218,R-HSA-168256,R-HSA-8851680","Adaptive Immune System|Immune System|Butyrophilin (BTN) family interactions"]
["C10orf95",0.110100266447555,0.0174539367325204,0.0172276784854662,0.0351975211517805,0.0717235638403944,0,0.0513612771591902,0.0539819890130112,0.0922882860007427,0.0176734447545575,0,0.0184616693104658,0,0.0699780831493433,0.0511963159517675,0.0347972590158569,0.0352849123103316,0.0679145992387343,0.0678380095750119,0.0705831674442852,0.0173197209114533,0.0174423935355925,0.0724621342129603,0.0537824729564491,0.109155960710727,0,0.0355140018991746,0,79946,"chromosome 10 open reading frame 95","protein_coding"]
["C13orf46",0.086244556387198,0.205082205421838,0.0854677806981599,0.0643327603988195,0.126411825124491,0.0584913575580501,0.0536435948431215,0.122158317831671,0.0481946292694955,0.161514426245214,0.0405540096239216,0.0626666368329126,0.027339269472425,0.0365438336816158,0.0133678258324114,0.0454294112107126,0.0690990972945394,0.0310329640940235,0.0398545291766456,0.0691121620438511,0.0497457110217161,0.0546524197023507,0.0898724950239039,0.074896506953927,0.0475026976786524,0.0409739205375071,0.0880937883938734,0.0225221838406177,100507747,"chromosome 13 open reading frame 46","protein_coding"]
["C16orf74",4.67517234595874,4.58758813259256,5.77821253193323,4.51214062181258,4.77077827152963,5.16823965529137,4.16864512922591,3.97513254110338,3.39300770656429,3.98981410342734,4.50803890954478,5.83486023550666,3.77069846815764,4.54183492523821,3.90759206546169,3.17027475568342,2.95866507306434,3.75082789258864,3.36373392867183,2.16251019378424,3.23968136355137,2.81260989064604,3.59302020980712,2.83301586965105,2.11218581274282,2.64286035281588,2.86334076783137,2.05851276954145,404550,"chromosome 16 open reading frame 74","protein_coding",null,null,"GO:0005515","protein binding"]
["C1GALT1C1",16.6985404112125,14.9754777165025,13.4655841962025,14.1560030382317,15.3264290481442,14.3087121310953,14.327656274199,15.0002451969904,13.5121586740837,10.12357007347,10.4319507411057,12.8250908991142,15.4973384906606,11.4993671950256,13.1585197895199,13.6557493350353,21.6880918822472,14.5538863837381,22.0473531118788,18.4663211826111,26.0055609485472,19.4013923595587,27.8333850837063,25.3304242943009,23.7391473720684,20.1591034348164,26.8496952483354,20.828625237052,29071,"C1GALT1 specific chaperone 1","protein_coding","hsa00512,hsa00514","Mucin type O-glycan biosynthesis|Other types of O-glycan biosynthesis","GO:0000139,GO:0005515,GO:0006493,GO:0016263,GO:0016267,GO:0030168,GO:0036344,GO:0070062","Golgi membrane|protein binding|protein O-linked glycosylation|glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity|O-glycan processing, core 1|platelet activation|platelet morphogenesis|extracellular exosome",null,null,"R-HSA-1643685,R-HSA-3781865,R-HSA-3906995,R-HSA-392499,R-HSA-5083632,R-HSA-5173105,R-HSA-5668914,R-HSA-597592,R-HSA-913709","Disease|Diseases of glycosylation|Diseases associated with O-glycosylation of proteins|Metabolism of proteins|Defective C1GALT1C1 causes TNPS|O-linked glycosylation|Diseases of metabolism|Post-translational protein modification|O-linked glycosylation of mucins"]
["C1QTNF1-AS1",0.0279049847155725,0,0.0523963968843682,0,0,0,0,0,0,0,0,0,0.0265373930386237,0,0,0,0,0,0.103161528018315,0,0,0,0,0.0817872181915359,0,0,0.054006282391188,0,100507410,"C1QTNF1 antisense RNA 1","non_coding"]
["C1orf147",0.0643039485573547,0,0.0362225091056534,0.0493369833701961,0.0502680893518794,0.0241538738712265,0,0.0504450011832783,0.0258724221631853,0.0247731778095849,0.0725689752366995,0.0388170690129881,0.0122304969824955,0.0367835654149757,0.0478418499574723,0.0121939822266922,0,0.0118996357683326,0,0.123672081316382,0.0242773568882872,0.0488986185186745,0,0.0753878366154807,0,0.0366601903536919,0.112006349978289,0.012090630370927,574431,"chromosome 1 open reading frame 147","non_coding"]
["C22orf39",3.1521380718631,2.69493944260439,3.204250945273,2.48101365728383,2.9951673497373,2.87155796849278,3.17754180905194,2.8351717923105,3.32368819427965,3.1057040869027,3.74128181365461,3.36815290437858,3.33532228248664,3.98617829250432,4.20514428271357,3.43529391762727,3.28836412349328,3.20486620447936,4.36656125771717,3.60952262106111,3.22137031691228,3.45771070002696,3.49815335703441,3.53263619477946,3.44838938245288,3.69051172168435,4.17921518800712,3.54242469190343,128977,"chromosome 22 open reading frame 39","protein_coding",null,null,"GO:0005515","protein binding","WP4657","22q11.2 copy number variation syndrome"]
["C2CD2L",1.93670722929075,1.96134916163746,1.70816812101656,1.97374574119772,1.40256036916703,1.82626038278068,1.28258104544418,1.52247507996018,1.54543773845311,2.43773717648456,2.1521720865558,1.73696146343044,1.52649517100619,1.4185387702816,1.36870602872183,1.26125319331203,1.0845625165218,1.75081534647652,1.547051557342,1.41525232350151,1.60662428048109,1.28364191070411,1.1056616326308,1.00333178362822,1.18653145992904,1.47909140582047,0.946839406566131,1.61166815256702,9854,"C2CD2 like","protein_coding",null,null,"GO:0005515,GO:0005789,GO:0005886,GO:0008526,GO:0015914,GO:0032541,GO:0035091,GO:0035774,GO:0043559,GO:0098592,GO:0120009,GO:0140268","protein binding|endoplasmic reticulum membrane|plasma membrane|phosphatidylinositol transfer activity|phospholipid transport|cortical endoplasmic reticulum|phosphatidylinositol binding|positive regulation of insulin secretion involved in cellular response to glucose stimulus|insulin binding|cytoplasmic side of apical plasma membrane|intermembrane lipid transfer|endoplasmic reticulum-plasma membrane contact site"]
["C2orf88",0.206358777837894,0.164328643432902,0.279341730656808,0.170294718458494,0.135993214490147,0.126183242812403,0.268647734188536,0.169413299327285,0.0820621458535356,0.0647092869542871,0.0496454303322456,0.0531105776015342,0.0821492238126384,0.105231862887967,0.187449427428173,0.0546026421516401,0.0968937386381895,0.0754865269177903,0.159673548974761,0.143060657924395,0.176653753024403,0.100356644878632,0.156344440103332,0.145344492075469,0.090399739463448,0.0638393345047022,0.111454660046047,0.0315815789215313,84281,"chromosome 2 open reading frame 88","protein_coding",null,null,"GO:0005515,GO:0005886,GO:0034237","protein binding|plasma membrane|protein kinase A regulatory subunit binding"]
["C5orf38",0.00629376960897574,0.00598641911278835,0,0,0,0,0.00587203020833141,0,0,0,0.0473514116572876,6.3320551522471E-3,0,0,5.85317052946895E-3,0,0,0,0,0.00605222233105621,0,0,0.024853344655344,0.00614884059249932,0.00623978933317998,0,0,0,153571,"chromosome 5 open reading frame 38","non_coding",null,null,"GO:0005515,GO:0005576","protein binding|extracellular region"]
["C7orf26",9.96094343512473,10.8067074588208,10.3624185490803,10.9064002571342,7.80307321394882,9.57958184623353,10.1028700954035,9.6446773801689,9.23084684719735,12.039898895679,13.6730942087182,11.9354083623029,9.1248707630613,10.6823619663556,10.6536509491958,8.8597815246023,7.637357018175,9.55499687149286,10.3170328148661,8.79467224250661,8.72094621819686,9.33908628831265,7.8834250311509,8.14878496999779,7.52321165582441,9.07736069651587,8.76918372253442,9.7967954143818,79034,"chromosome 7 open reading frame 26","protein_coding",null,null,"GO:0032039","integrator complex"]
["C9orf64",9.80849561994851,7.68915386207191,7.64467430267886,6.89778015118551,8.16736766041013,7.79364996911575,7.80734976243914,7.56194589166476,6.73175784284021,6.12487329463644,6.08197125793291,7.33457761159699,7.04476626191741,6.44588193938621,6.24222232778448,6.67068894382096,7.53668283298832,6.88138937003007,7.64340298431883,7.86790003041366,7.38031649403931,7.56298633088832,8.31918508147957,8.27112264581274,7.9465883279026,6.09839356994749,7.60457927471644,7.49849380718826,84267,"chromosome 9 open reading frame 64","protein_coding",null,null,"GO:0003674,GO:0005515,GO:0005575,GO:0008150,GO:0016787,GO:0043174,GO:0101030","molecular_function|protein binding|cellular_component|biological_process|hydrolase activity|nucleoside salvage|tRNA-guanine transglycosylation"]
["CA3",0.0156631116997345,0.134083961383296,0.0294101797735617,0.0450655071806788,0,0.0588338403650095,0.0438406253032251,0.0767959925044678,0.110284769894902,0.0754279208147736,0.147302510261594,0.0472751752767129,0.0744774017295484,0.119462875242748,0.116532850099781,0.0148510091499982,0.0301182662311895,0.0869551536447131,0.057904727522192,0.015061980385772,0.0739182743141342,0.0148883649644308,0.0463888183434799,0.107117019060849,0.0310575452806622,0.119062187071607,0.0757845275855427,0.161976510070943,761,"carbonic anhydrase 3","protein_coding","hsa00910","Nitrogen metabolism","GO:0004089,GO:0005515,GO:0005737,GO:0005829,GO:0006730,GO:0008270,GO:0009617,GO:0016151","carbonate dehydratase activity|protein binding|cytoplasm|cytosol|one-carbon metabolic process|zinc ion binding|response to bacterium|nickel cation binding",null,null,"R-HSA-1430728,R-HSA-1475029","Metabolism|Reversible hydration of carbon dioxide"]
["CACNA1C-AS4",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.0361081666074758,0,0.0362618964911938,0,0,0,100874234,"CACNA1C antisense RNA 4","non_coding"]
["CADM1",1.02396052478221,0.74343413458066,0.841875485475878,0.877442003187997,1.13082298374769,0.933102856820733,0.743360880595701,0.935766677378278,2.12697013958852,1.67188046385334,1.4786519989115,1.82569062014245,1.81502884417236,1.08886188365889,1.25937298627094,1.4534327819798,2.35633461298924,1.62857842744628,1.10316054759167,1.87610185986519,2.24746444536694,1.9322263278984,1.21424565392471,1.92972979725824,2.52593165851678,1.48244833578292,1.20487178425735,1.58921267494542,23705,"cell adhesion molecule 1","protein_coding","hsa04514","Cell adhesion molecules","GO:0001819,GO:0001889,GO:0001913,GO:0001933,GO:0005102,GO:0005515,GO:0005886,GO:0005911,GO:0006915,GO:0007156,GO:0007157,GO:0007283,GO:0008037,GO:0014069,GO:0016323,GO:0030154,GO:0030165,GO:0030425,GO:0042271,GO:0042803,GO:0043005,GO:0045202,GO:0045954,GO:0050798,GO:0050839,GO:0051606,GO:0120154","positive regulation of cytokine production|liver development|T cell mediated cytotoxicity|negative regulation of protein phosphorylation|signaling receptor binding|protein binding|plasma membrane|cell-cell junction|apoptotic process|homophilic cell adhesion via plasma membrane adhesion molecules|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules|spermatogenesis|cell recognition|postsynaptic density|basolateral plasma membrane|cell differentiation|PDZ domain binding|dendrite|susceptibility to natural killer cell mediated cytotoxicity|protein homodimerization activity|neuron projection|synapse|positive regulation of natural killer cell mediated cytotoxicity|activated T cell proliferation|cell adhesion molecule binding|detection of stimulus|negative regulation of ERBB4 signaling pathway","WP4148","Splicing factor NOVA regulated synaptic proteins","R-HSA-1500931,R-HSA-418990,R-HSA-420597,R-HSA-421270,R-HSA-446728","Cell-Cell communication|Adherens junctions interactions|Nectin/Necl  trans heterodimerization|Cell-cell junction organization|Cell junction organization"]
["CALCOCO1",11.325323619661,12.0294461109982,12.6495797229939,12.9135710897185,13.9607129464552,12.7105938930457,12.0016767239168,12.9738454568339,14.4330948989998,17.0811264122521,14.8537672488095,14.3962056750852,13.864321299635,16.2170363379506,14.5859742591234,15.5539382451069,12.6396307486758,12.2908523932646,11.2515257184698,13.4071731127097,12.3458282364708,12.3996568354002,11.6999045712055,12.6797280715861,12.7533292141306,12.437002642601,11.7335600763087,12.8247445786374,57658,"calcium binding and coiled-coil domain 1","protein_coding",null,null,"GO:0000785,GO:0000976,GO:0000978,GO:0003682,GO:0003712,GO:0003713,GO:0005515,GO:0005634,GO:0005829,GO:0007165,GO:0008013,GO:0010628,GO:0016055,GO:0030374,GO:0030518,GO:0043231,GO:0043565,GO:0045893,GO:0045944,GO:0046872","chromatin|transcription cis-regulatory region binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|chromatin binding|transcription coregulator activity|transcription coactivator activity|protein binding|nucleus|cytosol|signal transduction|beta-catenin binding|positive regulation of gene expression|Wnt signaling pathway|nuclear receptor coactivator activity|intracellular steroid hormone receptor signaling pathway|intracellular membrane-bounded organelle|sequence-specific DNA binding|positive regulation of DNA-templated transcription|positive regulation of transcription by RNA polymerase II|metal ion binding"]
["CAMK1D",1.03297265858361,0.864362384460924,0.818599233973014,0.772245690031063,1.20271026447946,0.898721181521795,0.764134703088923,0.848244082370421,2.14285570909096,2.14709049618223,2.10084406567856,2.10628786528443,2.08065210490913,2.60569666565472,2.40485631309654,2.39727633652935,1.26077987645344,1.1835410030858,0.708048007379781,1.24331975361266,1.20080195617184,1.13714223555248,0.722243456100339,1.11032936957337,1.28185200608291,0.981509822839206,0.821488238604955,1.04465027629552,57118,"calcium/calmodulin dependent protein kinase ID","protein_coding","hsa04020,hsa04921,hsa04925,hsa05214","Calcium signaling pathway|Oxytocin signaling pathway|Aldosterone synthesis and secretion|Glioma","GO:0004683,GO:0005515,GO:0005516,GO:0005524,GO:0005622,GO:0005634,GO:0005737,GO:0006954,GO:0007399,GO:0010976,GO:0016310,GO:0018105,GO:0032793,GO:0043065,GO:0043066,GO:0050766,GO:0050773,GO:0060267,GO:0071622,GO:0090023,GO:0106310","calmodulin-dependent protein kinase activity|protein binding|calmodulin binding|ATP binding|intracellular anatomical structure|nucleus|cytoplasm|inflammatory response|nervous system development|positive regulation of neuron projection development|phosphorylation|peptidyl-serine phosphorylation|positive regulation of CREB transcription factor activity|positive regulation of apoptotic process|negative regulation of apoptotic process|positive regulation of phagocytosis|regulation of dendrite development|positive regulation of respiratory burst|regulation of granulocyte chemotaxis|positive regulation of neutrophil chemotaxis|protein serine kinase activity","WP4756","Renin-angiotensin-aldosterone system (RAAS)"]
["CAPN11",0,0,0,0.00902358788341458,0,0,0,0,0,0,0.0353937340537806,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,11131,"calpain 11","protein_coding",null,null,"GO:0001669,GO:0004198,GO:0005509,GO:0005737,GO:0006508,GO:0008233","acrosomal vesicle|calcium-dependent cysteine-type endopeptidase activity|calcium ion binding|cytoplasm|proteolysis|peptidase activity","WP185","Integrin-mediated cell adhesion","R-HSA-1474228,R-HSA-1474244","Degradation of the extracellular matrix|Extracellular matrix organization"]
["CARD19",45.0615994312647,39.7594646300203,43.7049332753798,45.0633092853594,37.841678673986,39.6904914873257,48.0687707709772,44.2177168897407,33.7366846787784,40.5885115177557,38.0261430240305,34.9937964091282,34.9677235755388,36.9207551182438,36.4195531627871,35.2755609712926,40.9950721085618,37.8147393164511,46.124434319576,36.1051807683084,41.7107366784911,37.6372892077493,42.1863191873738,43.7508851377497,38.3941210707031,42.7871161762444,50.0363851009002,48.9029782330076,84270,"caspase recruitment domain family member 19","protein_coding",null,null,"GO:0005634,GO:0005739,GO:0005789,GO:0005829,GO:0031966,GO:0043124,GO:0050700","nucleus|mitochondrion|endoplasmic reticulum membrane|cytosol|mitochondrial membrane|negative regulation of canonical NF-kappaB signal transduction|CARD domain binding"]
["CASP10",0.479848857590715,0.556136992327676,0.423999324735495,0.440866722303969,0.6225573154257,0.469535410218941,0.466505350396881,0.336098781257025,0.381263134201901,0.353413376416529,0.462646666560132,0.25963983573564,0.40648061295182,0.334458076317708,0.34125516430398,0.386150674863401,0.465222463879226,0.380560498157572,0.309322550241304,0.38388110039603,0.452906167876152,0.398620660402945,0.469735649541621,0.445162261947229,0.263852082142805,0.291190310774456,0.433124729669224,0.307060413142035,843,"caspase 10","protein_coding","hsa04668,hsa04210,hsa04622,hsa05161,hsa05152","TNF signaling pathway|Apoptosis|RIG-I-like receptor signaling pathway|Hepatitis B|Tuberculosis","GO:0004197,GO:0005515,GO:0005737,GO:0005829,GO:0006508,GO:0006915,GO:0006919,GO:0008625,GO:0030225,GO:0031265,GO:0031625,GO:0035877,GO:0042981,GO:0043123,GO:0051604,GO:0097153,GO:0097199,GO:0097342","cysteine-type endopeptidase activity|protein binding|cytoplasm|cytosol|proteolysis|apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|extrinsic apoptotic signaling pathway via death domain receptors|macrophage differentiation|CD95 death-inducing signaling complex|ubiquitin protein ligase binding|death effector domain binding|regulation of apoptotic process|positive regulation of canonical NF-kappaB signal transduction|protein maturation|cysteine-type endopeptidase activity involved in apoptotic process|cysteine-type endopeptidase activity involved in apoptotic signaling pathway|ripoptosome","WP4666,WP5090,WP314,WP254,WP4655,WP1772,WP3865","Hepatitis B infection|Complement system in neuronal development and plasticity|Fas ligand pathway and stress induction of heat shock proteins|Apoptosis|Cytosolic DNA-sensing pathway|Apoptosis modulation and signaling|Novel intracellular components of RIG-I-like receptor pathway","R-HSA-162582,R-HSA-168249,R-HSA-168256,R-HSA-168928,R-HSA-212436,R-HSA-3700989,R-HSA-5633008,R-HSA-6803207,R-HSA-73857,R-HSA-73887,R-HSA-74160,R-HSA-75157,R-HSA-75158,R-HSA-933543","Signal Transduction|Innate Immune System|Immune System|DDX58/IFIH1-mediated induction of interferon-alpha/beta|Generic Transcription Pathway|Transcriptional Regulation by TP53|TP53 Regulates Transcription of Cell Death Genes|TP53 Regulates Transcription of Caspase Activators and Caspases|RNA Polymerase II Transcription|Death Receptor Signaling|Gene expression (Transcription)|FasL/ CD95L signaling|TRAIL  signaling|NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10"]
["CASP7",5.0744409335195,4.65330303586339,4.9088312357207,4.39614842772562,4.90373968679031,4.76515863430599,4.74094680243253,4.15810563575738,5.33684969039333,5.25861263086914,5.60933397702374,6.04316295632676,5.19901063617843,4.77771905646552,5.72952800910346,5.25658921398679,6.60385666409251,6.66666728923481,7.30692620138463,6.77360285624891,7.0784339366224,6.73549863258634,6.70482462486445,6.70370231104093,6.89319229648928,6.74628842503863,6.68742691456437,6.72095696375775,840,"caspase 7","protein_coding","hsa04668,hsa04210,hsa04215,hsa04623,hsa05200,hsa05130,hsa05132,hsa05133,hsa05134,hsa05010,hsa05022,hsa05417,hsa04932","TNF signaling pathway|Apoptosis|Apoptosis - multiple species|Cytosolic DNA-sensing pathway|Pathways in cancer|Pathogenic Escherichia coli infection|Salmonella infection|Pertussis|Legionellosis|Alzheimer disease|Pathways of neurodegeneration - multiple diseases|Lipid and atherosclerosis|Non-alcoholic fatty liver disease","GO:0003723,GO:0004190,GO:0004197,GO:0005515,GO:0005615,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006508,GO:0006915,GO:0007507,GO:0008233,GO:0008234,GO:0009411,GO:0016485,GO:0030163,GO:0032991,GO:0042742,GO:0044346,GO:0051146,GO:0051402,GO:0051604,GO:0070227,GO:0071222,GO:0072734,GO:0097153,GO:0097194,GO:0097200,GO:1905686","RNA binding|aspartic-type endopeptidase activity|cysteine-type endopeptidase activity|protein binding|extracellular space|nucleus|nucleoplasm|cytoplasm|cytosol|proteolysis|apoptotic process|heart development|peptidase activity|cysteine-type peptidase activity|response to UV|protein processing|protein catabolic process|protein-containing complex|defense response to bacterium|fibroblast apoptotic process|striated muscle cell differentiation|neuron apoptotic process|protein maturation|lymphocyte apoptotic process|cellular response to lipopolysaccharide|cellular response to staurosporine|cysteine-type endopeptidase activity involved in apoptotic process|execution phase of apoptosis|cysteine-type endopeptidase activity involved in execution phase of apoptosis|positive regulation of plasma membrane repair","WP1433,WP3853,WP5124,WP2374,WP2507,WP5090,WP2864,WP5413,WP384,WP2059,WP2371,WP4298,WP314,WP2328,WP3303,WP4864,WP3646,WP254,WP5182,WP4396,WP2036,WP231,WP1772,WP4906","Nucleotide-binding oligomerization domain (NOD) pathway|ERK pathway in Huntington's disease|Alzheimer's disease|Oncostatin M signaling pathway|Nanomaterial induced apoptosis|Complement system in neuronal development and plasticity|Apoptosis-related network due to altered Notch3 in ovarian cancer|IL-24 Signaling pathway|Apoptosis modulation by HSP70|Alzheimer's disease and miRNA effects|Parkinson's disease pathway|Acute viral myocarditis|Fas ligand pathway and stress induction of heat shock proteins|Allograft rejection|RAC1/PAK1/p38/MMP2 pathway|Host-pathogen interaction of human coronaviruses - apoptosis|Hepatitis C and hepatocellular carcinoma|Apoptosis|Pro-survival signaling of neuroprotectin D1|Nonalcoholic fatty liver disease|TNF-related weak inducer of apoptosis (TWEAK) signaling pathway|TNF-alpha signaling pathway|Apoptosis modulation and signaling|3q29 copy number variation syndrome","R-HSA-109581,R-HSA-109606,R-HSA-111459,R-HSA-111461,R-HSA-111463,R-HSA-111464,R-HSA-111465,R-HSA-111469,R-HSA-111471,R-HSA-264870,R-HSA-5357801,R-HSA-75153","Apoptosis|Intrinsic Pathway for Apoptosis|Activation of caspases through apoptosome-mediated cleavage|Cytochrome c-mediated apoptotic response|SMAC (DIABLO) binds to IAPs |SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes |Apoptotic cleavage of cellular proteins|SMAC, XIAP-regulated apoptotic response|Apoptotic factor-mediated response|Caspase-mediated cleavage of cytoskeletal proteins|Programmed Cell Death|Apoptotic execution phase"]
["CAVIN1",247.216312859235,255.399599695766,257.640930623827,281.554092161132,233.667820509377,262.743363482678,255.986287892608,252.597533272342,248.927105102309,300.330286827592,279.420219077855,268.852355484375,227.456469129378,235.374063310774,209.117058176054,211.63791475044,286.035948892022,338.881295806764,304.745700955087,304.82767693145,299.137906736946,327.556377861354,250.413473831801,274.709698784554,283.248094616539,333.912645644223,258.637174476484,317.191492246701,284119,"caveolae associated protein 1","protein_coding",null,null,"GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005783,GO:0005829,GO:0005886,GO:0005901,GO:0006361,GO:0006363,GO:0009303,GO:0009306,GO:0032991,GO:0042134,GO:0042802,GO:0043231,GO:0045121,GO:2000147","RNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|mitochondrion|endoplasmic reticulum|cytosol|plasma membrane|caveola|transcription initiation at RNA polymerase I promoter|termination of RNA polymerase I transcription|rRNA transcription|protein secretion|protein-containing complex|rRNA primary transcript binding|identical protein binding|intracellular membrane-bounded organelle|membrane raft|positive regulation of cell motility","WP5101","Congenital generalized lipodystrophy","R-HSA-162582,R-HSA-194315,R-HSA-73863,R-HSA-73864,R-HSA-74160,R-HSA-8980692,R-HSA-9012999,R-HSA-9013026,R-HSA-9013106,R-HSA-9716542","Signal Transduction|Signaling by Rho GTPases|RNA Polymerase I Transcription Termination|RNA Polymerase I Transcription|Gene expression (Transcription)|RHOA GTPase cycle|RHO GTPase cycle|RHOB GTPase cycle|RHOC GTPase cycle|Signaling by Rho GTPases, Miro GTPases and RHOBTB3"]
["CBX6",22.1502409723833,23.6062706230542,22.0415763471802,21.7730661964068,22.1143378860501,23.8660708056941,20.4457261204287,21.0085259058793,24.3276008689208,29.6687376110677,26.8838715497056,26.4166446000749,26.312851263554,26.5699711064083,25.0649870893186,27.2731912116779,17.8145663024561,20.4206558503729,15.3465898237318,18.3490460602985,18.7709057558658,19.0647407626149,15.1130993853655,18.0719210380242,18.9618681533308,18.223837969467,14.3528031287446,18.0978117241829,23466,"chromobox 6","protein_coding","hsa03083","Polycomb repressive complex","GO:0000122,GO:0000785,GO:0000792,GO:0003682,GO:0003727,GO:0005515,GO:0005634,GO:0005654,GO:0006325,GO:0016604,GO:0031519,GO:0035064,GO:0035102","negative regulation of transcription by RNA polymerase II|chromatin|heterochromatin|chromatin binding|single-stranded RNA binding|protein binding|nucleus|nucleoplasm|chromatin organization|nuclear body|PcG protein complex|methylated histone binding|PRC1 complex",null,null,"R-HSA-1257604,R-HSA-1257604,R-HSA-162582,R-HSA-162582,R-HSA-212436,R-HSA-2262752,R-HSA-2559580,R-HSA-2559583,R-HSA-6807070,R-HSA-6807070,R-HSA-73857,R-HSA-74160,R-HSA-8878171,R-HSA-8939243,R-HSA-8943724,R-HSA-8943724,R-HSA-8953897,R-HSA-9006925,R-HSA-9006925","PIP3 activates AKT signaling|PIP3 activates AKT signaling|Signal Transduction|Signal Transduction|Generic Transcription Pathway|Cellular responses to stress|Oxidative Stress Induced Senescence|Cellular Senescence|PTEN Regulation|PTEN Regulation|RNA Polymerase II Transcription|Gene expression (Transcription)|Transcriptional regulation by RUNX1|RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known|Regulation of PTEN gene transcription|Regulation of PTEN gene transcription|Cellular responses to stimuli|Intracellular signaling by second messengers|Intracellular signaling by second messengers"]
["CCDC121",0.455938745780777,0.442523870556999,0.6464452942496,0.37480439420479,0.35460085398516,0.576691455963063,0.62505805575575,0.45621644149185,0.496050333666539,0.25989175698616,0.393781253269215,0.767640925716291,0.407047151213077,0.576618680489735,0.96918967563139,0.5205235133178,0.608332837504944,0.180798884355861,0.515985688983565,0.447388129856986,0.430338567803702,0.406852709966907,0.541971490712071,0.418167854971705,0.332102394789214,0.362493397564707,0.783361405716296,0.37614923509524,79635,"coiled-coil domain containing 121","protein_coding",null,null,"GO:0005515","protein binding"]
["CCDC157",0.701748969006161,0.383262536504275,0.52706163960339,0.594861162609949,0.482215685492433,0.60370891736991,0.283010356166105,0.501671046366186,0.446288418852499,0.593025106960787,0.506674618727985,0.61947365494157,0.54249669652152,0.423000705674578,0.408415443338664,0.519413670877523,0.539751300537518,0.477552329363196,0.368221161142968,0.561621633097896,0.423047418856831,0.559451443314093,0.594450554086561,0.561741098542941,0.610447163101333,0.520524624159777,0.424966129712722,0.557574223165545,550631,"coiled-coil domain containing 157","protein_coding",null,null,"GO:0005515","protein binding"]
["CCDC18",1.07778899789676,0.889634446329882,0.509169692076331,0.826489107608145,0.91619056766556,0.664661894599315,0.353771047576877,0.525058063467077,0.700394921004817,0.416104909186332,0.412787343994875,0.564136990704701,0.666556872205432,0.313301065493033,0.397515606500859,0.305047071150943,1.44939470318087,1.06315586404199,1.04708950938589,1.10051072339889,1.45975421336202,1.16209463659112,1.4905284948712,1.36728984764909,1.48320430791307,1.12017039947219,1.25644027563028,0.974358442209363,343099,"coiled-coil domain containing 18","protein_coding",null,null,"GO:0005737,GO:0034451","cytoplasm|centriolar satellite"]
["CCDC28B",2.7787895197129,2.8106096494163,3.55498617133321,3.54710525230544,2.94477948336788,3.13314758534028,3.5328542224841,3.80906450314156,3.35607105757285,3.67524255329712,4.69288153472609,3.94743995609684,3.24742557701756,4.15109100228144,3.42141293866462,2.97796963551149,3.75346296503938,3.97436604516031,4.65715322811539,3.36840552861021,3.55550924039424,4.36193426231411,4.07627779646369,4.04352444319286,3.47279722018712,4.862334415879,4.77199903268663,4.59926701587351,79140,"coiled-coil domain containing 28B","protein_coding",null,null,"GO:0005515,GO:0005737,GO:0005813,GO:0060271","protein binding|cytoplasm|centrosome|cilium assembly","WP4803","Ciliopathies"]
["CCDC81",0.117558723223912,0.0614998176320972,0.10484992023721,0.101471091833338,0.143591794703362,0.0331180895992743,0.131617472563193,0.0806944022417203,0.100510918722047,0.0509508532708255,0.121612901079905,0.147842303843623,0.0950277079110945,0.0560389250688974,0.0273322387458738,0.0668781162158227,0.062164075231427,0.0761410623606526,0.0271625697954896,0.0339140884133193,0.0554790013495966,0.0670463395650731,0.0406197190422956,0.0516832442911189,0.0174825671918948,0.0837764489547954,0.102383475601611,0.138148502275747,60494,"coiled-coil domain containing 81","protein_coding",null,null,"GO:0005515,GO:0005737,GO:0005813","protein binding|cytoplasm|centrosome"]
["CCDC87",0.0653370867890241,0.0887805853880628,0.0350518832342796,0.0447586206474771,0.100327308526396,0.0613548541271875,0.0522504959465723,0.0915276337258927,0.0469430374428985,0.143835403570332,0.0438898234349383,0.0563438896476614,0.0177528543457829,0.0444935094123898,0.043402232302139,0.0353997046359375,0.0628176511923719,0.0777267067637904,0.0603859290564272,0.0628295282920347,0.149766409391179,0.044360935082731,0.129004176958426,0.0547136099536175,0.0462690749896292,0.0975574040621794,0.0270966423770191,0.0877491733291656,55231,"coiled-coil domain containing 87","protein_coding",null,null,"GO:0005515,GO:0007283,GO:0007338,GO:0030154,GO:1905516,GO:2000344","protein binding|spermatogenesis|single fertilization|cell differentiation|positive regulation of fertilization|positive regulation of acrosome reaction"]
["CCL28",0.88772003969589,0.573414796870631,0.715251379931736,0.654415253491331,0.705606338516084,0.740299316350061,0.611904800404537,0.727578331148743,0.619717314748757,0.350927984503435,0.274129645786408,0.533206040148918,0.617410155856583,0.505273060439348,0.474397385619094,0.672098496422885,0.414005880062916,0.331002303957473,0.140823471953239,0.458677835724205,0.443949267963548,0.346340178350503,0.333545750374832,0.336555709363253,0.380941515707194,0.264378625150832,0.237194955176436,0.473332282026835,56477,"C-C motif chemokine ligand 28","protein_coding","hsa04060,hsa04061,hsa04672,hsa04062","Cytokine-cytokine receptor interaction|Viral protein interaction with cytokine and cytokine receptor|Intestinal immune network for IgA production|Chemokine signaling pathway","GO:0001954,GO:0005515,GO:0005576,GO:0006935,GO:0006955,GO:0007165,GO:0007204,GO:0007584,GO:0008009,GO:0060326,GO:0070062,GO:1903237","positive regulation of cell-matrix adhesion|protein binding|extracellular region|chemotaxis|immune response|signal transduction|positive regulation of cytosolic calcium ion concentration|response to nutrient|chemokine activity|cell chemotaxis|extracellular exosome|negative regulation of leukocyte tethering or rolling","WP5095,WP3929,WP5285,WP5098","Overview of proinflammatory and profibrotic mediators|Chemokine signaling pathway|Immune infiltration in pancreatic cancer|T-cell activation SARS-CoV-2","R-HSA-162582,R-HSA-372790,R-HSA-373076,R-HSA-375276,R-HSA-380108,R-HSA-388396,R-HSA-418594,R-HSA-500792","Signal Transduction|Signaling by GPCR|Class A/1 (Rhodopsin-like receptors)|Peptide ligand-binding receptors|Chemokine receptors bind chemokines|GPCR downstream signalling|G alpha (i) signalling events|GPCR ligand binding"]
["CCNJ",1.36010082949858,1.29368154649606,1.35383371013567,1.16297317152749,1.26498348134371,0.89763332684558,1.06511250757796,1.00162204173193,1.81311418053009,1.20999529467525,1.34073938929712,1.74206705832068,1.94795757411174,1.45291729264648,1.63063637897602,1.45531162633197,1.25513831286186,1.27361548444724,1.38829077599115,1.42871200858045,1.50026686433782,1.32397840049955,2.22708001218846,1.44084716303386,1.38092796698531,1.3131009133589,1.51700200027332,1.18108431392431,54619,"cyclin J","protein_coding",null,null,"GO:0000079,GO:0000307,GO:0005634,GO:0005737,GO:0016538,GO:0044772","regulation of cyclin-dependent protein serine/threonine kinase activity|cyclin-dependent protein kinase holoenzyme complex|nucleus|cytoplasm|cyclin-dependent protein serine/threonine kinase regulator activity|mitotic cell cycle phase transition"]
["CCSER1",0,0,0,0,0,0,0.000630276053988007,0,0.00611554734839896,5.85571543743592E-3,0.00444716773455987,7.47618260250652E-3,0.00706679543965156,0.00450833664777521,0.0150780418781839,0.00768621509575126,0.00064949422579602,0.000625056676701631,0.00124870355694675,0.00129923405477852,0.000637612961905747,0.000642129065578664,0.00133382045408664,1.31997515262885E-3,0.00133949917119063,0.00128377580601856,0.00065371110931368,0.00190526736767634,401145,"coiled-coil serine rich protein 1","protein_coding"]
["CCT7",143.483893576488,127.229009454846,149.36997464297,143.859758149616,120.143648359121,127.163368604253,147.043525424279,139.478866583767,125.978226843959,131.023450534373,151.955083573177,146.968786127713,117.896365483651,113.83530793311,126.959433595447,112.131234633183,164.912152345215,165.913972606312,189.183515887364,161.211122012271,151.118207625919,165.610658178422,171.818856598523,169.465929412407,158.603458934691,171.929747368563,185.863881438174,178.975266433542,10574,"chaperonin containing TCP1 subunit 7","protein_coding",null,null,"GO:0005515,GO:0005524,GO:0005737,GO:0005829,GO:0005832,GO:0005874,GO:0006457,GO:0007339,GO:0016887,GO:0032212,GO:0044183,GO:0044297,GO:0050821,GO:0051082,GO:0061077,GO:0070062,GO:0140662,GO:1904851,GO:1904871,GO:1904874","protein binding|ATP binding|cytoplasm|cytosol|chaperonin-containing T-complex|microtubule|protein folding|binding of sperm to zona pellucida|ATP hydrolysis activity|positive regulation of telomere maintenance via telomerase|protein folding chaperone|cell body|protein stabilization|unfolded protein binding|chaperone-mediated protein folding|extracellular exosome|ATP-dependent protein folding chaperone|positive regulation of establishment of protein localization to telomere|positive regulation of protein localization to Cajal body|positive regulation of telomerase RNA localization to Cajal body","WP4949,WP3888","16p11.2 proximal deletion syndrome|VEGFA-VEGFR2 signaling","R-HSA-162582,R-HSA-194315,R-HSA-389957,R-HSA-389958,R-HSA-389960,R-HSA-390450,R-HSA-390466,R-HSA-390466,R-HSA-390471,R-HSA-390471,R-HSA-391251,R-HSA-391251,R-HSA-392499,R-HSA-392499,R-HSA-6814122,R-HSA-9012999,R-HSA-9013418,R-HSA-9013422,R-HSA-9706574,R-HSA-9716542","Signal Transduction|Signaling by Rho GTPases|Prefoldin mediated transfer of substrate  to CCT/TriC|Cooperation of Prefoldin and TriC/CCT  in actin and tubulin folding|Formation of tubulin folding intermediates by CCT/TriC|Folding of actin by CCT/TriC|Chaperonin-mediated protein folding|Chaperonin-mediated protein folding|Association of TriC/CCT with target proteins during biosynthesis|Association of TriC/CCT with target proteins during biosynthesis|Protein folding|Protein folding|Metabolism of proteins|Metabolism of proteins|Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding|RHO GTPase cycle|RHOBTB2 GTPase cycle|RHOBTB1 GTPase cycle|RHOBTB GTPase Cycle|Signaling by Rho GTPases, Miro GTPases and RHOBTB3"]
["CD276",41.7803578428722,46.2260178648264,42.8993117836361,47.8494115691022,42.3321687287291,50.3730535278858,40.4916790212785,48.8474033434322,57.5223232242222,79.508231458008,65.1972166736123,60.5862950240728,55.3299819874753,64.0488558377149,57.7812054458175,62.1285804327879,38.2502814447821,43.3833314891638,37.1569067280513,41.6454311681534,38.3617807241868,40.6387592275849,29.9285417113256,34.2465388172922,38.1333256709785,41.6426273970011,30.4016092566103,38.4102664434591,80381,"CD276 molecule","protein_coding","hsa04514","Cell adhesion molecules","GO:0001817,GO:0005102,GO:0005515,GO:0009897,GO:0016020,GO:0032729,GO:0042102,GO:0042110,GO:0050776,GO:0050852","regulation of cytokine production|signaling receptor binding|protein binding|external side of plasma membrane|membrane|positive regulation of type II interferon production|positive regulation of T cell proliferation|T cell activation|regulation of immune response|T cell receptor signaling pathway","WP5078","T cell modulation in pancreatic cancer"]
["CD5L",0,0,0,0,0,0,0,0.00945054723633816,0,0,0,0.00969617169005161,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,922,"CD5 molecule like","protein_coding",null,null,"GO:0002376,GO:0004252,GO:0005576,GO:0005615,GO:0005737,GO:0005886,GO:0006915,GO:0006954,GO:0006968,GO:0009986,GO:0030449,GO:0031638,GO:0072562,GO:1903661","immune system process|serine-type endopeptidase activity|extracellular region|extracellular space|cytoplasm|plasma membrane|apoptotic process|inflammatory response|cellular defense response|cell surface|regulation of complement activation|zymogen activation|blood microparticle|positive regulation of complement-dependent cytotoxicity","WP5323","Fatty Acids and Lipoproteins Transport in Hepatocytes"]
["CDC20-DT",0.0234198220983867,0.0445522729106386,0,0.0673829173396597,0.0457697286192612,0.0219924064440012,0.131102895129192,0.183723236281757,0,0.0225562904817072,0.0220249887193921,0.0942491475832297,0.133632258950359,0.044655866266892,0.130681821256553,0.111027744340342,0.0900669612230707,0.0216695365511947,0.238096089644356,0.0225209976054854,0,0,0.323687283280569,0.205924724864527,0.0696568663266981,0.0445060868701641,0.158640521950136,0.132104055208321,105378687,null,"non_coding"]
["CDC40",7.83050460707632,6.10598771241426,5.49563390114941,4.85698885263993,6.62095476957069,5.68056050830818,5.85896992450708,4.82222315535284,6.5695436717445,4.58158064901972,5.05175848414606,6.14930505051569,8.1442495915861,5.65401242033436,7.18488134017967,6.53038780323577,8.65011591148404,6.2370249521794,8.05056899286852,7.46952451081423,7.71389580775907,6.81904476770864,10.3509173110531,10.2912439130793,8.40047848849286,6.55762994502568,9.43630681921263,7.19083896784712,51362,"cell division cycle 40","protein_coding","hsa03040","Spliceosome","GO:0000398,GO:0003723,GO:0003729,GO:0005515,GO:0005654,GO:0016607,GO:0071007,GO:0071013,GO:1990403","mRNA splicing, via spliceosome|RNA binding|mRNA binding|protein binding|nucleoplasm|nuclear speck|U2-type catalytic step 2 spliceosome|catalytic step 2 spliceosome|embryonic brain development","WP411","mRNA processing","R-HSA-159236,R-HSA-72163,R-HSA-72172,R-HSA-72187,R-HSA-72202,R-HSA-72203,R-HSA-73856,R-HSA-73857,R-HSA-74160,R-HSA-8953854","Transport of Mature mRNA derived from an Intron-Containing Transcript|mRNA Splicing - Major Pathway|mRNA Splicing|mRNA 3'-end processing|Transport of Mature Transcript to Cytoplasm|Processing of Capped Intron-Containing Pre-mRNA|RNA Polymerase II Transcription Termination|RNA Polymerase II Transcription|Gene expression (Transcription)|Metabolism of RNA"]
["CDCA5",14.9205205225231,10.0793899379468,4.04568144045764,10.2251194293638,8.63253482557582,7.9378383466849,2.54385218571802,7.13209116809667,7.72109859130729,9.18761595856263,4.85771207032362,7.33193347101583,4.23489199813644,2.1536235990102,1.1173057395459,1.71209107913901,11.1635077930047,11.8151601047517,5.54520056570506,9.62290913458341,11.129046213242,10.7565476678021,5.11354084029649,9.25642721306577,10.8697429933683,10.8618785714212,5.158529620137,10.0975575546817,113130,"cell division cycle associated 5","protein_coding","hsa04110,hsa05206","Cell cycle|MicroRNAs in cancer","GO:0000278,GO:0000775,GO:0000785,GO:0003682,GO:0005515,GO:0005634,GO:0005654,GO:0005694,GO:0005737,GO:0005829,GO:0006302,GO:0007064,GO:0007076,GO:0007080,GO:0031536,GO:0044877,GO:0051301","mitotic cell cycle|chromosome, centromeric region|chromatin|chromatin binding|protein binding|nucleus|nucleoplasm|chromosome|cytoplasm|cytosol|double-strand break repair|mitotic sister chromatid cohesion|mitotic chromosome condensation|mitotic metaphase chromosome alignment|positive regulation of exit from mitosis|protein-containing complex binding|cell division","WP5117","Cohesin complex - Cornelia de Lange syndrome","R-HSA-1640170,R-HSA-2467813,R-HSA-2468052,R-HSA-2500257,R-HSA-2555396,R-HSA-68877,R-HSA-68882,R-HSA-68886,R-HSA-69242,R-HSA-69278","Cell Cycle|Separation of Sister Chromatids|Establishment of Sister Chromatid Cohesion|Resolution of Sister Chromatid Cohesion|Mitotic Metaphase and Anaphase|Mitotic Prometaphase|Mitotic Anaphase|M Phase|S Phase|Cell Cycle, Mitotic"]
["CDIPTOSP",0.0332792780682013,0,0.124975109605678,0.223417351854172,0.227633767583572,0.031250938045735,0.0620985318081073,0.195801337926206,0.167372212512458,0.576939785432112,0.125188948227261,0.23437203150558,0.189889790187485,0.285549455962181,0.15474771220812,0.347091918788414,0.287964089910428,0.0923764317423155,0.184544511232764,0.160010297801936,0.125642814908271,0.537764066375744,0.131415895257825,0.19507766116796,0.329938490296418,0.0316212999923203,0.322037461665972,0.187718231536763,440356,"CDIP transferase opposite strand%2C pseudogene","non_coding"]
["CDK6",5.48767543100165,4.63095487299646,3.64242140371125,3.51440220909283,5.61214361555787,3.6369384113175798,3.11339926862211,3.3536273249216,6.9658031233471,5.67412119258379,5.42025444102931,6.39422834801902,7.14243115562521,4.20983519892331,4.76355170538288,4.95649465121459,5.17041679571287,4.81402635968273,4.08938047332802,5.824827448154,5.34465405971594,5.13736534194034,5.72306930710478,5.33063504150767,5.48952318934196,4.66664093647063,4.67013261380358,4.13019152274293,1021,"cyclin dependent kinase 6","protein_coding","hsa04151,hsa04110,hsa04115,hsa04218,hsa05200,hsa05206,hsa05203,hsa05212,hsa05225,hsa05214,hsa05220,hsa05218,hsa05224,hsa05222,hsa05223,hsa05160,hsa05164,hsa05162,hsa05163,hsa05167,hsa05169,hsa05165,hsa04934","PI3K-Akt signaling pathway|Cell cycle|p53 signaling pathway|Cellular senescence|Pathways in cancer|MicroRNAs in cancer|Viral carcinogenesis|Pancreatic cancer|Hepatocellular carcinoma|Glioma|Chronic myeloid leukemia|Melanoma|Breast cancer|Small cell lung cancer|Non-small cell lung cancer|Hepatitis C|Influenza A|Measles|Human cytomegalovirus infection|Kaposi sarcoma-associated herpesvirus infection|Epstein-Barr virus infection|Human papillomavirus infection|Cushing syndrome","GO:0000082,GO:0000122,GO:0000307,GO:0001726,GO:0001954,GO:0003323,GO:0004693,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005813,GO:0005829,GO:0006468,GO:0007165,GO:0007219,GO:0008285,GO:0009615,GO:0010033,GO:0010389,GO:0010468,GO:0010628,GO:0014002,GO:0021542,GO:0021670,GO:0030332,GO:0033077,GO:0042063,GO:0043697,GO:0045596,GO:0045638,GO:0045646,GO:0045656,GO:0045668,GO:0045786,GO:0048146,GO:0048699,GO:0050680,GO:0051301,GO:0051726,GO:0060218,GO:0097132,GO:0098770,GO:0106310,GO:1902036,GO:2000145,GO:2000773","G1/S transition of mitotic cell cycle|negative regulation of transcription by RNA polymerase II|cyclin-dependent protein kinase holoenzyme complex|ruffle|positive regulation of cell-matrix adhesion|type B pancreatic cell development|cyclin-dependent protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|centrosome|cytosol|protein phosphorylation|signal transduction|Notch signaling pathway|negative regulation of cell population proliferation|response to virus|response to organic substance|regulation of G2/M transition of mitotic cell cycle|regulation of gene expression|positive regulation of gene expression|astrocyte development|dentate gyrus development|lateral ventricle development|cyclin binding|T cell differentiation in thymus|gliogenesis|cell dedifferentiation|negative regulation of cell differentiation|negative regulation of myeloid cell differentiation|regulation of erythrocyte differentiation|negative regulation of monocyte differentiation|negative regulation of osteoblast differentiation|negative regulation of cell cycle|positive regulation of fibroblast proliferation|generation of neurons|negative regulation of epithelial cell proliferation|cell division|regulation of cell cycle|hematopoietic stem cell differentiation|cyclin D2-CDK6 complex|FBXO family protein binding|protein serine kinase activity|regulation of hematopoietic stem cell differentiation|regulation of cell motility|negative regulation of cellular senescence","WP4204,WP4630,WP4262,WP5413,WP4685,WP2261,WP179,WP4844,WP4258,WP3998,WP5180,WP2446,WP363,WP4658,WP707,WP1545,WP45,WP4263,WP4674,WP4255,WP2249,WP1530,WP4172","Tumor suppressor activity of SMARCB1|Measles virus infection|Breast cancer pathway|IL-24 Signaling pathway|Melanoma|Glioblastoma signaling pathways|Cell cycle|Influence of laminopathies on Wnt signaling|lncRNA in canonical Wnt signaling and colorectal cancer|Prader-Willi and Angelman syndrome|DYRK1A involvement regarding cell proliferation in brain development|Retinoblastoma gene in cancer|Wnt signaling pathway|Small cell lung cancer|DNA damage response|miRNAs involved in DNA damage response|G1 to S cell cycle control|Pancreatic adenocarcinoma pathway|Head and neck squamous cell carcinoma|Non-small cell lung cancer|Metastatic brain tumor|miRNA regulation of DNA damage response|PI3K-Akt signaling pathway","R-HSA-1640170,R-HSA-1643685,R-HSA-212436,R-HSA-2262752,R-HSA-2559580,R-HSA-2559582,R-HSA-2559583,R-HSA-2559585,R-HSA-453279,R-HSA-69231,R-HSA-69236,R-HSA-69278,R-HSA-73857,R-HSA-74160,R-HSA-8878171,R-HSA-8934593,R-HSA-8953897,R-HSA-9630747,R-HSA-9630750,R-HSA-9630794,R-HSA-9632693,R-HSA-9632700,R-HSA-9659787,R-HSA-9661069,R-HSA-9675126,R-HSA-9675132,R-HSA-9687139,R-HSA-9754119","Cell Cycle|Disease|Generic Transcription Pathway|Cellular responses to stress|Oxidative Stress Induced Senescence|Senescence-Associated Secretory Phenotype (SASP)|Cellular Senescence|Oncogene Induced Senescence|Mitotic G1 phase and G1/S transition|Cyclin D associated events in G1|G1 Phase|Cell Cycle, Mitotic|RNA Polymerase II Transcription|Gene expression (Transcription)|Transcriptional regulation by RUNX1|Regulation of RUNX1 Expression and Activity|Cellular responses to stimuli|Diseases of Cellular Senescence|Evasion of Oncogene Induced Senescence Due to p16INK4A Defects|Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6|Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects|Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6|Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects|Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)|Diseases of mitotic cell cycle|Diseases of cellular response to stress|Aberrant regulation of mitotic cell cycle due to RB1 defects|Drug-mediated inhibition of CDK4/CDK6 activity"]
["CDKL4",0.00437387883096594,0.0208014222457184,0.024638123993331,0.00419480436248301,0.00427397027752472,0.012321885356342,0.0163231578012548,0,0.0307967043629932,0,0.0041133801745936,0,0.041595199862584,0.00833991596190048,0.0528798769933963,0.0248826091972872,0.0252313173051487,0.0323759682887232,0.00404243209742384,0.0168240585714189,0.00412829304217507,0.0291027312553136,0.0302258691429446,0.0170926394662823,0.0173454601421449,0.00415597160372861,0.0380926999114869,0.00822390435095344,344387,"cyclin dependent kinase like 4","protein_coding",null,null,"GO:0004674,GO:0004693,GO:0005524,GO:0005634,GO:0005737,GO:0006468,GO:0016310,GO:0051726,GO:0106310","protein serine/threonine kinase activity|cyclin-dependent protein serine/threonine kinase activity|ATP binding|nucleus|cytoplasm|protein phosphorylation|phosphorylation|regulation of cell cycle|protein serine kinase activity"]
["CDS2",6.61367294499149,5.94376788677435,4.95775426721223,4.8356232273055,5.94894905206184,5.43992052580022,5.05200069314797,5.5753997527092,5.97264518131711,5.06020562976499,4.68627159742969,5.55301518085156,5.61876162080481,5.35671574188333,5.6318867908548,5.4366986832554,6.50046486516537,5.87124784853507,5.37879957871238,5.74088483841926,6.07019427971169,5.75373906738073,6.00226509762927,6.1469551356586,6.44793234070977,5.49164861223706,5.82378043799163,5.18134816277848,8760,"CDP-diacylglycerol synthase 2","protein_coding","hsa00564,hsa04070","Glycerophospholipid metabolism|Phosphatidylinositol signaling system","GO:0004605,GO:0005515,GO:0005743,GO:0005783,GO:0005789,GO:0006655,GO:0016020,GO:0016024,GO:0140042","phosphatidate cytidylyltransferase activity|protein binding|mitochondrial inner membrane|endoplasmic reticulum|endoplasmic reticulum membrane|phosphatidylglycerol biosynthetic process|membrane|CDP-diacylglycerol biosynthetic process|lipid droplet formation","WP2533","Glycerophospholipid biosynthetic pathway","R-HSA-1430728,R-HSA-1483148,R-HSA-1483206,R-HSA-1483257,R-HSA-556833","Metabolism|Synthesis of PG|Glycerophospholipid biosynthesis|Phospholipid metabolism|Metabolism of lipids"]
["CELF3",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4.43856278334279E-3,0,0,0,0,0,0,0,0,0.00877316423832144,0,0,11189,"CUGBP Elav-like family member 3","protein_coding",null,null,"GO:0000381,GO:0003723,GO:0003729,GO:0005634,GO:0005737,GO:0006376,GO:0007283,GO:0008380,GO:0016604,GO:0030317,GO:0030575,GO:0036002,GO:0048026,GO:0097322,GO:0098781,GO:1990904","regulation of alternative mRNA splicing, via spliceosome|RNA binding|mRNA binding|nucleus|cytoplasm|mRNA splice site recognition|spermatogenesis|RNA splicing|nuclear body|flagellated sperm motility|nuclear body organization|pre-mRNA binding|positive regulation of mRNA splicing, via spliceosome|7SK snRNA binding|ncRNA transcription|ribonucleoprotein complex","WP3527","Pre-implantation embryo"]
["CENPV",5.28646623871375,5.5266071260227,5.85738024746401,6.18908921069022,5.14244330327301,6.55193032366987,5.70982834209085,5.27729577749871,5.46118378212027,7.91253548483529,8.12926379135635,8.43313397562736,5.5482374650628,6.243241197053,6.71019982460053,4.5608078824414,9.52418332707283,9.07769811573779,10.0578388873722,8.01465007541503,8.58577733854183,9.41618061764553,7.75783321608144,8.98012095712225,8.40468754963561,10.1819468614847,8.94080684208321,11.0815113272475,201161,"centromere protein V","protein_coding",null,null,"GO:0000776,GO:0001667,GO:0003674,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0007049,GO:0015630,GO:0016846,GO:0030496,GO:0031508,GO:0031965,GO:0032467,GO:0033044,GO:0034508,GO:0046872,GO:0051233,GO:0051301","kinetochore|ameboidal-type cell migration|molecular_function|protein binding|nucleus|nucleoplasm|cytosol|cell cycle|microtubule cytoskeleton|carbon-sulfur lyase activity|midbody|pericentric heterochromatin formation|nuclear membrane|positive regulation of cytokinesis|regulation of chromosome organization|centromere complex assembly|metal ion binding|spindle midzone|cell division"]
["CEP41",2.49415957344801,2.44837992823921,2.3027951261306,2.19909477210281,1.92551296969381,2.08593062187287,2.50187689775706,1.89985952110076,2.40344512178967,2.05181989942296,2.37930677136353,2.61469596776414,2.37978636961271,2.07571478569789,2.3733783666051,2.53469268425851,2.00582695487143,2.17515754979784,2.28223127274462,2.24737497912676,1.85467986131208,1.92544872060958,2.43507701838157,2.12439393510942,2.10663415371655,2.08970206410755,2.40021786682848,1.90952105579698,95681,"centrosomal protein 41","protein_coding",null,null,"GO:0005515,GO:0005813,GO:0005814,GO:0005829,GO:0005929,GO:0015031,GO:0016020,GO:0018095,GO:0036064,GO:0060271","protein binding|centrosome|centriole|cytosol|cilium|protein transport|membrane|protein polyglutamylation|ciliary basal body|cilium assembly","WP4656,WP4803,WP5234","Joubert syndrome|Ciliopathies|Bardet-Biedl syndrome","R-HSA-1640170,R-HSA-1852241,R-HSA-2565942,R-HSA-380259,R-HSA-380270,R-HSA-380284,R-HSA-380287,R-HSA-380320,R-HSA-453274,R-HSA-5617833,R-HSA-5620912,R-HSA-68877,R-HSA-68886,R-HSA-69275,R-HSA-69278,R-HSA-8854518","Cell Cycle|Organelle biogenesis and maintenance|Regulation of PLK1 Activity at G2/M Transition|Loss of Nlp from mitotic centrosomes|Recruitment of mitotic centrosome proteins and complexes|Loss of proteins required for interphase microtubule organization from the centrosome|Centrosome maturation|Recruitment of NuMA to mitotic centrosomes|Mitotic G2-G2/M phases|Cilium Assembly|Anchoring of the basal body to the plasma membrane|Mitotic Prometaphase|M Phase|G2/M Transition|Cell Cycle, Mitotic|AURKA Activation by TPX2"]
["CEP57",11.6978706062873,10.9332535285247,10.224410025513,9.11329879592067,10.4431116202344,10.035853924448,10.3504243223791,9.15849050571446,10.6272158669998,7.05977384500963,7.61451459821857,9.75298444522669,11.9199725437018,8.671695824889,10.7979292450017,10.0229751949595,12.8159842212883,10.4474340644056,12.2125044198152,12.5000417000385,13.2010233582356,11.334575445178,18.4120295267739,14.8615887245959,13.2617357887017,11.1702702131888,16.0129849151464,10.9591286885861,9702,"centrosomal protein 57","protein_coding",null,null,"GO:0005515,GO:0005634,GO:0005794,GO:0005813,GO:0005829,GO:0005874,GO:0007286,GO:0008017,GO:0008543,GO:0017134,GO:0034451,GO:0042803,GO:0043015,GO:0051260","protein binding|nucleus|Golgi apparatus|centrosome|cytosol|microtubule|spermatid development|microtubule binding|fibroblast growth factor receptor signaling pathway|fibroblast growth factor binding|centriolar satellite|protein homodimerization activity|gamma-tubulin binding|protein homooligomerization",null,null,"R-HSA-1640170,R-HSA-1852241,R-HSA-2565942,R-HSA-380259,R-HSA-380270,R-HSA-380284,R-HSA-380287,R-HSA-380320,R-HSA-453274,R-HSA-5617833,R-HSA-5620912,R-HSA-68877,R-HSA-68886,R-HSA-69275,R-HSA-69278,R-HSA-8854518","Cell Cycle|Organelle biogenesis and maintenance|Regulation of PLK1 Activity at G2/M Transition|Loss of Nlp from mitotic centrosomes|Recruitment of mitotic centrosome proteins and complexes|Loss of proteins required for interphase microtubule organization from the centrosome|Centrosome maturation|Recruitment of NuMA to mitotic centrosomes|Mitotic G2-G2/M phases|Cilium Assembly|Anchoring of the basal body to the plasma membrane|Mitotic Prometaphase|M Phase|G2/M Transition|Cell Cycle, Mitotic|AURKA Activation by TPX2"]
["CETN3",9.01803972155631,7.27393165505689,8.40518132732379,9.01397437574218,7.85537282012284,7.28343593605865,8.14986845115965,7.54167017690344,7.80165245297174,3.96034937457636,8.06150139976757,7.73768196023872,9.39333756302744,6.31596678018045,7.14237503658884,7.06522676424359,11.3581961855711,9.59216289411429,13.4520884035408,11.8310761839654,11.3865702384938,9.77143580229106,19.7278964554869,12.2962692841523,12.0143945655395,11.7419916872209,16.2110383245413,10.5438103536902,1070,"centrin 3","protein_coding",null,null,"GO:0005509,GO:0005515,GO:0005730,GO:0005737,GO:0005813,GO:0005814,GO:0005815,GO:0007098,GO:0008017,GO:0015031,GO:0031683,GO:0032391,GO:0036064,GO:0044615,GO:0051028,GO:0051301,GO:0070390","calcium ion binding|protein binding|nucleolus|cytoplasm|centrosome|centriole|microtubule organizing center|centrosome cycle|microtubule binding|protein transport|G-protein beta/gamma-subunit complex binding|photoreceptor connecting cilium|ciliary basal body|nuclear pore nuclear basket|mRNA transport|cell division|transcription export complex 2","WP4262","Breast cancer pathway"]
["CFAP43",0.0301355117219039,0.071659678759286,0.0235769141933574,0.0385356128727151,0.0539864481133283,0.018865854158409,0.0421742404398269,0.0147753944214856,0.101040799057269,0.0435365405440666,0.0425110598368144,0.0555845191704523,0.066870077036398,0.0335189411694008,0.0700646433139058,0.0380973903441727,0.0144867345399321,0.0185888850906839,0.0232099021952889,0.0289789471703899,0.0521463331857975,0.0525156767545444,0.0347087817268432,0.0343484981933523,0.0597540921498264,0.00954471883502122,0.0388821082838737,0.00944362260386176,80217,"cilia and flagella associated protein 43","protein_coding",null,null,"GO:0003356,GO:0005576,GO:0005930,GO:0007288,GO:0007420,GO:0051649,GO:0060271,GO:0090660,GO:0097729,GO:0120197","regulation of cilium beat frequency|extracellular region|axoneme|sperm axoneme assembly|brain development|establishment of localization in cell|cilium assembly|cerebrospinal fluid circulation|9+2 motile cilium|mucociliary clearance"]
["CFAP58",0.190415525310378,0.102370340841812,0.209859155948724,0.134979683004209,0.0970779317704601,0.108840797739138,0.0849658965617684,0.105537883310961,0.0832748723188519,0.103657793144283,0.249147538240986,0.0916222710036296,0.0944783354126925,0.102608373303363,0.123189824951919,0.0706471992396566,0.071637258239388,0.114903116878494,0.0688641219741425,0.0636896025648987,0.109397229811102,0.0550860358496616,0.122596984596328,0.056618055836524,0.0820792927334455,0.125863651075083,0.120170612998819,0.0233494729030679,159686,"cilia and flagella associated protein 58","protein_coding",null,null,"GO:0005515,GO:0005615,GO:0005737,GO:0005813,GO:0005856,GO:0007219,GO:0007288,GO:0030317,GO:0036126,GO:0060271,GO:0097225,GO:0120229,GO:0120316,GO:0120317","protein binding|extracellular space|cytoplasm|centrosome|cytoskeleton|Notch signaling pathway|sperm axoneme assembly|flagellated sperm motility|sperm flagellum|cilium assembly|sperm midpiece|protein localization to motile cilium|sperm flagellum assembly|sperm mitochondrial sheath assembly"]
["CGB7",0.313298642901477,0.178799393724355,0.305901418909296,0.276433902174618,0.0857198287971613,0.223594577649401,0.0935375374515424,0.196620590386148,0.0882380701948523,0.120698699881195,0.0589278521990245,0.0756490717352143,0.059588846293144,0.155319787761856,0.221438148850113,0.130704069836641,0.253022840507071,0.405837880039461,0.220063538499321,0.180764771575409,0.130111283220908,0.512219280549872,0.197948628840239,0.159163782124486,0.260913701531477,0.166706435105956,0.0727616022174164,0.270974016235076,94027,"chorionic gonadotropin subunit beta 7","protein_coding",null,null,"GO:0005179,GO:0005615,GO:0005737,GO:0006915,GO:0007165,GO:0007186,GO:0007267,GO:0007292","hormone activity|extracellular space|cytoplasm|apoptotic process|signal transduction|G protein-coupled receptor signaling pathway|cell-cell signaling|female gamete generation"]
["CHCHD7",11.6015897227383,9.13478435650017,13.1025386881188,11.318201730814,10.039780175054,10.35847000454,14.2990991956444,11.8942316183335,15.329841566996,10.0330714406802,15.2050891287194,16.1515173341496,14.5614005069392,12.5572225022649,15.2086936298898,14.5314569435869,18.5766564301137,17.5608134667366,23.9375430729528,14.6692765234218,16.3107852794696,18.1218435546095,24.6535245537278,22.3203336667745,16.9206570597966,18.9014688582999,27.0240403975145,19.8818351421705,79145,"coiled-coil-helix-coiled-coil-helix domain containing 7","protein_coding",null,null,"GO:0003674,GO:0005575,GO:0005739,GO:0005758,GO:0008150,GO:0033108","molecular_function|cellular_component|mitochondrion|mitochondrial intermembrane space|biological_process|mitochondrial respiratory chain complex assembly",null,null,"R-HSA-1268020,R-HSA-9609507","Mitochondrial protein import|Protein localization"]
["CHM",4.10003401627498,3.65112097295426,2.65159165213518,2.28710731265889,4.52858583855049,3.63159749666841,2.93799790012605,2.55541407187958,3.0749961123798,2.03945938860115,1.73202285784151,2.43971884792269,3.7898010833144,2.20507973613942,2.92588964704737,3.37802681373504,2.80659095943398,1.96194071508993,2.6395254702968,2.90658654792126,3.11863893858066,2.40880161197386,4.46459660786644,3.40491818424208,2.87987560316179,2.04480137415698,3.55881944420465,1.94210937370666,1121,"CHM Rab escort protein","protein_coding",null,null,"GO:0004663,GO:0005092,GO:0005096,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0005968,GO:0006612,GO:0007264,GO:0007601,GO:0016192,GO:0018344,GO:0031267","Rab geranylgeranyltransferase activity|GDP-dissociation inhibitor activity|GTPase activator activity|protein binding|nucleus|cytoplasm|cytosol|Rab-protein geranylgeranyltransferase complex|protein targeting to membrane|small GTPase mediated signal transduction|visual perception|vesicle-mediated transport|protein geranylgeranylation|small GTPase binding",null,null,"R-HSA-199991,R-HSA-212436,R-HSA-3700989,R-HSA-392499,R-HSA-5633008,R-HSA-5653656,R-HSA-597592,R-HSA-6803205,R-HSA-73857,R-HSA-74160,R-HSA-8873719,R-HSA-8876198,R-HSA-9007101","Membrane Trafficking|Generic Transcription Pathway|Transcriptional Regulation by TP53|Metabolism of proteins|TP53 Regulates Transcription of Cell Death Genes|Vesicle-mediated transport|Post-translational protein modification|TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain|RNA Polymerase II Transcription|Gene expression (Transcription)|RAB geranylgeranylation|RAB GEFs exchange GTP for GDP on RABs|Rab regulation of trafficking"]
["CHRDL1",0.0963213408099549,0.157058701746233,0.0645928016721538,0.1121730086426,0.0806752796949,0.109832929272529,0.154057613367739,0.0539728037162589,0.0346022185132953,0.0463848985224899,0.032351661582466,0.0899853238442998,0.0261716403014911,0.0459153030260782,0.0703829563948113,0.0260935035703388,0.0132295906543841,0.0127318206076698,0.0190761937338615,0.0264641840162468,6.49379020391144E-3,0.0261591384418432,0.0135843383306328,0.00672166520103996,0.0545686936477996,0.019611985446998,0.0133154846324368,0.0323404303949247,91851,"chordin like 1","protein_coding",null,null,"GO:0000578,GO:0001503,GO:0001654,GO:0005576,GO:0005788,GO:0005886,GO:0030154,GO:0030509,GO:0030514,GO:0036122,GO:0045202,GO:0048167,GO:0050431,GO:0060074,GO:0097113,GO:0098976","embryonic axis specification|ossification|eye development|extracellular region|endoplasmic reticulum lumen|plasma membrane|cell differentiation|BMP signaling pathway|negative regulation of BMP signaling pathway|BMP binding|synapse|regulation of synaptic plasticity|transforming growth factor beta binding|synapse maturation|AMPA glutamate receptor clustering|excitatory chemical synaptic transmission",null,null,"R-HSA-162582,R-HSA-201451,R-HSA-381426,R-HSA-392499,R-HSA-597592,R-HSA-8957275,R-HSA-9006936","Signal Transduction|Signaling by BMP|Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)|Metabolism of proteins|Post-translational protein modification|Post-translational protein phosphorylation|Signaling by TGFB family members"]
["CHRNA10",0.0678509552846824,0.0414884030098261,0.0500507113712061,0.092961450147367,0.0663010973544386,0.0591643972710517,0.0271304265181051,0.0855442738512551,0.121872970276061,0.13069833326941,0.113946251420443,0.0731396769608262,0.1106154117597,0.0877902858136157,0.0270432895120987,0.0597377971436371,0.0792134227908946,0.0807172704544505,0.0537508285143972,0.0652469175503043,0.0731899892669544,0.0829219291384642,0.0813375079872464,0.0426140521968844,0.139342954639749,0.0828907863876358,0.0750378551454694,0.145800568183893,57053,"cholinergic receptor nicotinic alpha 10 subunit","protein_coding","hsa04080","Neuroactive ligand-receptor interaction","GO:0004888,GO:0005102,GO:0005262,GO:0007165,GO:0007204,GO:0007268,GO:0007271,GO:0010996,GO:0016020,GO:0022848,GO:0030424,GO:0034220,GO:0042127,GO:0042391,GO:0042472,GO:0043005,GO:0043204,GO:0045202,GO:0050877,GO:0050910,GO:0051899,GO:0060079,GO:0070373,GO:0070588,GO:0098981,GO:0099634","transmembrane signaling receptor activity|signaling receptor binding|calcium channel activity|signal transduction|positive regulation of cytosolic calcium ion concentration|chemical synaptic transmission|synaptic transmission, cholinergic|response to auditory stimulus|membrane|acetylcholine-gated monoatomic cation-selective channel activity|axon|monoatomic ion transmembrane transport|regulation of cell population proliferation|regulation of membrane potential|inner ear morphogenesis|neuron projection|perikaryon|synapse|nervous system process|detection of mechanical stimulus involved in sensory perception of sound|membrane depolarization|excitatory postsynaptic potential|negative regulation of ERK1 and ERK2 cascade|calcium ion transmembrane transport|cholinergic synapse|postsynaptic specialization membrane",null,null,"R-HSA-9659379,R-HSA-9662361,R-HSA-9667769,R-HSA-9709957","Sensory processing of sound|Sensory processing of sound by outer hair cells of the cochlea|Acetylcholine inhibits contraction of outer hair cells|Sensory Perception"]
["CHST5",0.0227542615941838,0.0216430779910572,0.0498458688424449,0.0290968815824229,0.0222345066013378,0.078347174447805,0,0.0446255159595461,0.0457754053354274,0.0730509013630981,0.106995337715336,0.129725173801424,0.0288521346936528,0.0289245369010651,0.0846453439877845,0.0791064868369769,0.0729228139896977,0.091232773048826,0.0280399651282196,0.131285883058651,0.0644299465870357,0.0720958809898296,0.00748782183165719,0.0370504843242467,0.0902364132155651,0.0792756845615008,0.0366981350519749,0.0427832773057901,23563,"carbohydrate sulfotransferase 5","protein_coding",null,null,"GO:0000139,GO:0001517,GO:0005794,GO:0005802,GO:0005975,GO:0006044,GO:0006477,GO:0006790,GO:0008146,GO:0016020,GO:0018146","Golgi membrane|N-acetylglucosamine 6-O-sulfotransferase activity|Golgi apparatus|trans-Golgi network|carbohydrate metabolic process|N-acetylglucosamine metabolic process|protein sulfation|sulfur compound metabolic process|sulfotransferase activity|membrane|keratan sulfate biosynthetic process","WP702","Metapathway biotransformation Phase I and II","R-HSA-1430728,R-HSA-1630316,R-HSA-1638074,R-HSA-2022854,R-HSA-71387","Metabolism|Glycosaminoglycan metabolism|Keratan sulfate/keratin metabolism|Keratan sulfate biosynthesis|Metabolism of carbohydrates"]
["CIRBP-AS1",0.457221939830819,0.359260197744379,0.261286457029571,0.438502451015932,0.233101582481281,0.280013936029263,0.408036812986899,0.175441464292286,0.43990749660354,0.344632172713872,0.168257270017834,0.240001701036056,0.26466939782769,0.379047950392276,0.129412909766968,0.113091091801535,0.382253216695259,0.33108367128883,0.128609559819293,0.439674313871693,0.0938151549370391,0.321230747613829,0.196251613493434,0.0776857942704265,0.394174302566517,0.509998400318617,0.0769470041148784,0.242953905860633,148046,"CIRBP antisense RNA 1","non_coding"]
["CIZ1",39.4830527672434,48.6702725890512,53.5249762148808,48.3292203834179,39.4863482395988,48.0503618150152,51.9020119797745,48.9324778964115,41.7071378659315,58.6090297492891,55.1444410863948,45.9100478345609,38.6796919171749,46.1340132142547,45.8374749948872,42.0571510708404,37.2275225513069,42.1957372589799,48.5164739423709,41.5445610792622,38.6650568170235,42.1968062718962,38.1694914493694,36.4018628557706,37.2511283124435,43.6569535564076,37.9450024518571,46.1286664601878,25792,"CDKN1A interacting zinc finger protein 1","protein_coding",null,null,"GO:0003676,GO:0005515,GO:0005634,GO:0005654,GO:0005886,GO:0008270,GO:0030332,GO:0032298,GO:0051457","nucleic acid binding|protein binding|nucleus|nucleoplasm|plasma membrane|zinc ion binding|cyclin binding|positive regulation of DNA-templated DNA replication initiation|maintenance of protein location in nucleus"]
["CLDN10",0.00813649720351437,0,0.01527766960166,0.0156067487388969,0,0,0,0.00797862379113728,0.0409210661440057,0,0,0.00818599221764997,0,0,0,0,0.00782274919768747,0,0,0.0156484565311885,0,0,0.00803251397214297,0.0079491350008073,0.00806671225898275,0.0154622716533531,0,0,9071,"claudin 10","protein_coding","hsa04514,hsa04530,hsa04670,hsa05160,hsa05130","Cell adhesion molecules|Tight junction|Leukocyte transendothelial migration|Hepatitis C|Pathogenic Escherichia coli infection","GO:0005198,GO:0005515,GO:0005737,GO:0005886,GO:0005923,GO:0006811,GO:0007155,GO:0016338,GO:0042802,GO:0043269,GO:0070830","structural molecule activity|protein binding|cytoplasm|plasma membrane|bicellular tight junction|monoatomic ion transport|cell adhesion|calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules|identical protein binding|regulation of monoatomic ion transport|bicellular tight junction assembly","WP4239","Epithelial to mesenchymal transition in colorectal cancer","R-HSA-1500931,R-HSA-420029,R-HSA-421270,R-HSA-446728","Cell-Cell communication|Tight junction interactions|Cell-cell junction organization|Cell junction organization"]
["CLDN4",0.715651731909109,0.393295374372794,0.343405057810293,0.427063256641603,0.699304747443845,0.313615608352774,0.207727832066058,0.374275123823544,0.399915906003218,0.306339709078998,0.119649614234904,0.176001247426441,0.211735518262152,0.257752606266748,0.118320374644085,0.135709310161841,0.0611605146712415,0.191292787855768,0.0293964708158385,0.137637176516356,0.195135522269041,0.075583705320901,0.0628005163178989,0.233057382811279,0.157669721026606,0.241777019410307,0.123115206583805,0.254167163054201,1364,"claudin 4","protein_coding","hsa04514,hsa04530,hsa04670,hsa05160,hsa05130","Cell adhesion molecules|Tight junction|Leukocyte transendothelial migration|Hepatitis C|Pathogenic Escherichia coli infection","GO:0004888,GO:0005198,GO:0005254,GO:0005515,GO:0005886,GO:0005911,GO:0005923,GO:0007155,GO:0007565,GO:0007623,GO:0009925,GO:0016324,GO:0016327,GO:0016328,GO:0016338,GO:0022604,GO:0030335,GO:0032570,GO:0034707,GO:0042802,GO:0061436,GO:0070160,GO:0070293,GO:0070830,GO:0090303,GO:1902476,GO:1905050","transmembrane signaling receptor activity|structural molecule activity|chloride channel activity|protein binding|plasma membrane|cell-cell junction|bicellular tight junction|cell adhesion|female pregnancy|circadian rhythm|basal plasma membrane|apical plasma membrane|apicolateral plasma membrane|lateral plasma membrane|calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules|regulation of cell morphogenesis|positive regulation of cell migration|response to progesterone|chloride channel complex|identical protein binding|establishment of skin barrier|tight junction|renal absorption|bicellular tight junction assembly|positive regulation of wound healing|chloride transmembrane transport|positive regulation of metallopeptidase activity","WP4932,WP4239,WP4754,WP3594,WP2813,WP5094","7q11.23 copy number variation syndrome|Epithelial to mesenchymal transition in colorectal cancer|IL-18 signaling pathway|Circadian rhythm genes|Mammary gland development pathway - Embryonic development (Stage 1 of 4)|Orexin receptor pathway","R-HSA-1500931,R-HSA-420029,R-HSA-421270,R-HSA-446728","Cell-Cell communication|Tight junction interactions|Cell-cell junction organization|Cell junction organization"]
["CLK2",14.3791510238135,18.7954022292732,18.8924768754879,20.0075439506654,15.6404235892628,17.6158665114907,15.8325309648915,16.3090515524745,16.6537682539206,22.3945847075111,22.5261645769094,20.044264628404,15.0192774160826,18.9226227223963,16.6661992891776,16.0542097812858,14.2458001025326,18.2256898615827,16.1116611234342,18.1475746108737,14.729345178087,17.4506774578705,14.8131155194344,14.9283316056734,16.7992915435326,18.8591547112972,14.5562726753586,17.1770025236286,1196,"CDC like kinase 2","protein_coding",null,null,"GO:0004674,GO:0004712,GO:0004713,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0006468,GO:0010212,GO:0016604,GO:0016607,GO:0018108,GO:0042802,GO:0043484,GO:0045721,GO:0046777,GO:0106310","protein serine/threonine kinase activity|protein serine/threonine/tyrosine kinase activity|protein tyrosine kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|protein phosphorylation|response to ionizing radiation|nuclear body|nuclear speck|peptidyl-tyrosine phosphorylation|identical protein binding|regulation of RNA splicing|negative regulation of gluconeogenesis|protein autophosphorylation|protein serine kinase activity","WP4016,WP411","DNA IR-damage and cellular response via ATR|mRNA processing"]
["CLSTN1",58.1020170142836,63.918884709991,62.1533326999095,62.95280394822,63.6953469238661,64.6841559354192,60.3389761530221,60.149022918139,62.417410530454,72.8124899098203,65.3517012918157,63.486020345025,58.5353746203765,67.5981050006018,61.3418651565224,66.7184307306653,52.7589610922531,62.0189425790821,47.7153862782123,57.8889651836924,51.4543454376343,57.8476997998073,38.2146482375815,46.865382528833,54.8161705188317,57.099118025223,37.2230156287931,53.4748244688583,22883,"calsyntenin 1","protein_coding",null,null,"GO:0000139,GO:0001540,GO:0001558,GO:0005509,GO:0005515,GO:0005576,GO:0005634,GO:0005789,GO:0007155,GO:0007156,GO:0009986,GO:0014069,GO:0019894,GO:0042988,GO:0043005,GO:0045211,GO:0050806,GO:0051965,GO:0090128,GO:0098845,GO:0098969,GO:0098978,GO:0099003","Golgi membrane|amyloid-beta binding|regulation of cell growth|calcium ion binding|protein binding|extracellular region|nucleus|endoplasmic reticulum membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|cell surface|postsynaptic density|kinesin binding|X11-like protein binding|neuron projection|postsynaptic membrane|positive regulation of synaptic transmission|positive regulation of synapse assembly|regulation of synapse maturation|postsynaptic endosome|neurotransmitter receptor transport to postsynaptic membrane|glutamatergic synapse|vesicle-mediated transport in synapse","WP4148","Splicing factor NOVA regulated synaptic proteins"]
["CLUAP1",5.99804411676126,5.48128568957662,6.18056177075982,6.80170502686899,5.61863918207359,5.33979572355794,7.83338251642618,6.35568925243476,5.46380624272618,5.18265635474293,6.36460849104428,6.41208886302701,5.77062436957203,6.36119021646757,6.38263109923431,6.84497309061154,6.21929050247795,6.50907268685471,7.20128564066029,6.03697181612621,5.85937846589684,5.8887874764245,6.98259350971145,6.68640421454881,5.85831558667181,6.09810577412068,6.64128176312986,6.15908921547591,23059,"clusterin associated protein 1","protein_coding",null,null,"GO:0001843,GO:0001947,GO:0005515,GO:0005654,GO:0005813,GO:0005929,GO:0007224,GO:0021508,GO:0030991,GO:0030992,GO:0035082,GO:0035720,GO:0043231,GO:0060271,GO:0097542,GO:0097546","neural tube closure|heart looping|protein binding|nucleoplasm|centrosome|cilium|smoothened signaling pathway|floor plate formation|intraciliary transport particle A|intraciliary transport particle B|axoneme assembly|intraciliary anterograde transport|intracellular membrane-bounded organelle|cilium assembly|ciliary tip|ciliary base","WP5381,WP4352,WP4536,WP4803,WP5234","Smith-Magenis and Potocki-Lupski syndrome copy number variation|Ciliary landscape|Genes related to primary cilium development (based on CRISPR)|Ciliopathies|Bardet-Biedl syndrome","R-HSA-1852241,R-HSA-1852241,R-HSA-5617833,R-HSA-5617833,R-HSA-5620924,R-HSA-5620924","Organelle biogenesis and maintenance|Organelle biogenesis and maintenance|Cilium Assembly|Cilium Assembly|Intraflagellar transport|Intraflagellar transport"]
["CMTR2",4.90878008966445,4.94476142261544,4.55586943523509,3.69450664787544,5.07074774377856,4.33301898012899,4.55803869658103,4.02961598422012,4.70244509660391,3.22840134876294,3.46451621030593,4.06379571202779,5.77523812976559,3.98016125141875,4.9303490659607,5.23051202941958,4.72398946663674,3.43888329404926,5.0855359195855,4.97663661914889,4.91997521177617,4.49711248994639,7.65213835472401,5.70465137666242,4.51442373455525,3.94460087729381,6.39685026612045,3.81052383111697,55783,"cap methyltransferase 2","protein_coding",null,null,"GO:0004483,GO:0005634,GO:0005737,GO:0006370,GO:0097309,GO:0097310","mRNA (nucleoside-2'-O-)-methyltransferase activity|nucleus|cytoplasm|7-methylguanosine mRNA capping|cap1 mRNA methylation|cap2 mRNA methylation","WP3651","Pathways affected in adenoid cystic carcinoma"]
["CNNM2",1.36861572609659,1.22071736347007,1.08565880038706,1.18757431349037,1.50391054451518,1.37150759903897,1.08357722650096,1.32075776949665,2.02378124766784,1.96193862314044,1.66742040164885,2.19066458736891,1.78465325406817,1.65530528963012,1.54632593954664,1.7111942028962,1.1117973789363,0.924623313440845,0.742880034523558,0.867751587112605,0.929002085496673,0.929228350425546,0.864456056401206,1.02853853340369,1.2558157229694,1.13053351506856,0.777813002539704,0.895475662807881,54805,"cyclin and CBS domain divalent metal cation transport mediator 2","protein_coding",null,null,"GO:0005524,GO:0005886,GO:0006810,GO:0010960,GO:0015095,GO:0016323,GO:1903830","ATP binding|plasma membrane|transport|magnesium ion homeostasis|magnesium ion transmembrane transporter activity|basolateral plasma membrane|magnesium ion transmembrane transport"]
["CNOT4",3.92772237365065,3.40268697941654,2.96018062332066,3.84736352910562,3.75603752536697,3.18790458614812,3.075258428586,3.10153190141758,3.85645430675327,3.21261363222494,3.21582977797951,3.57928950915442,3.62260917688811,3.05777835873835,3.55180416224635,3.83636118115695,2.98401009149357,2.9447841090837,2.69520114016219,3.29774106343036,3.21351680634418,3.02052575706348,3.04941167167458,3.08524801847185,2.90095835702138,3.1647347191655,2.82671432579292,2.68588606408037,4850,"CCR4-NOT transcription complex subunit 4","protein_coding","hsa03018","RNA degradation","GO:0000289,GO:0003723,GO:0004842,GO:0005515,GO:0005634,GO:0005829,GO:0006511,GO:0016567,GO:0030014,GO:0045652,GO:0046872,GO:0051865","nuclear-transcribed mRNA poly(A) tail shortening|RNA binding|ubiquitin-protein transferase activity|protein binding|nucleus|cytosol|ubiquitin-dependent protein catabolic process|protein ubiquitination|CCR4-NOT complex|regulation of megakaryocyte differentiation|metal ion binding|protein autoubiquitination",null,null,"R-HSA-212436,R-HSA-3700989,R-HSA-429914,R-HSA-429947,R-HSA-6791312,R-HSA-6804115,R-HSA-73857,R-HSA-74160,R-HSA-8953854","Generic Transcription Pathway|Transcriptional Regulation by TP53|Deadenylation-dependent mRNA decay|Deadenylation of mRNA|TP53 Regulates Transcription of Cell Cycle Genes|TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain|RNA Polymerase II Transcription|Gene expression (Transcription)|Metabolism of RNA"]
["CNTN4-AS1",0,0,0,0.0510920539248671,0,0,0,0,0.0535855700138699,0.051308874198508,0,0,0.430629514308576,0,0,0,0,0.0246458859391553,0,0,0,0.0253190475333848,0.026296164811966,0.052046411576432,0,0,0.0515514513734067,0.0250414636931453,100873975,"CNTN4 antisense RNA 1","non_coding"]
["COL11A1",0.0993716462346146,0.148079645345712,0.0310978860839885,0.0984799653312197,0.213623937348906,0.130641055826481,0.0216329979940998,0.074706703644737,0.356504046656543,0.200986027488331,0.171331028616505,0.166626887546536,0.315005181559481,0.243162660336436,0.181749647737185,0.260673715902333,0.0286619455428173,0.00306483614775438,0.00612275965014085,0.025482101984678,0.0125056131820717,0.0409311119868777,0.0130802255048953,0.0161805629501564,0.0361237644205097,0.0157368229256447,0.00641067446422801,0.00622805634245835,1301,"collagen type XI alpha 1 chain","protein_coding","hsa04974","Protein digestion and absorption","GO:0001502,GO:0001503,GO:0002063,GO:0005201,GO:0005576,GO:0005592,GO:0005615,GO:0005788,GO:0006029,GO:0007601,GO:0007605,GO:0008201,GO:0030020,GO:0030198,GO:0030199,GO:0030674,GO:0035987,GO:0035989,GO:0042472,GO:0046872,GO:0048704,GO:0050840,GO:0050910,GO:0055010,GO:0062023,GO:1904399","cartilage condensation|ossification|chondrocyte development|extracellular matrix structural constituent|extracellular region|collagen type XI trimer|extracellular space|endoplasmic reticulum lumen|proteoglycan metabolic process|visual perception|sensory perception of sound|heparin binding|extracellular matrix structural constituent conferring tensile strength|extracellular matrix organization|collagen fibril organization|protein-macromolecule adaptor activity|endodermal cell differentiation|tendon development|inner ear morphogenesis|metal ion binding|embryonic skeletal system morphogenesis|extracellular matrix binding|detection of mechanical stimulus involved in sensory perception of sound|ventricular cardiac muscle tissue morphogenesis|collagen-containing extracellular matrix|heparan sulfate binding","WP3932","Focal adhesion: PI3K-Akt-mTOR-signaling pathway","R-HSA-1442490,R-HSA-1442490,R-HSA-1474228,R-HSA-1474228,R-HSA-1474244,R-HSA-1474244,R-HSA-1474290,R-HSA-162582,R-HSA-1650814,R-HSA-2022090,R-HSA-3000171,R-HSA-6806834,R-HSA-8874081,R-HSA-8875878,R-HSA-8948216,R-HSA-9006934","Collagen degradation|Collagen degradation|Degradation of the extracellular matrix|Degradation of the extracellular matrix|Extracellular matrix organization|Extracellular matrix organization|Collagen formation|Signal Transduction|Collagen biosynthesis and modifying enzymes|Assembly of collagen fibrils and other multimeric structures|Non-integrin membrane-ECM interactions|Signaling by MET|MET activates PTK2 signaling|MET promotes cell motility|Collagen chain trimerization|Signaling by Receptor Tyrosine Kinases"]
["COL25A1",0.021905907770957,0.00568258711437777,0.00186964093492537,0.0038198255446192,0.005837872078986,0.00374013886185658,0,0.00390561179374081,0.0160249990703417,0.0134261253258802,0,0.0180320426975228,0.0208323240564728,0.0170874009551837,0.011112202738349,0.00944096732681254,0.0038293097062557,0.00737045997944007,0,0.00191501686199126,0.0244351884047004,0,1.96599577347145E-3,0.00194558837601023,0.00394873193173904,0.00567669614223835,0,0,84570,"collagen type XXV alpha 1 chain","protein_coding","hsa04974","Protein digestion and absorption","GO:0001540,GO:0005576,GO:0005581,GO:0005615,GO:0005788,GO:0005886,GO:0008201,GO:0016020,GO:0030020,GO:0062023","amyloid-beta binding|extracellular region|collagen trimer|extracellular space|endoplasmic reticulum lumen|plasma membrane|heparin binding|membrane|extracellular matrix structural constituent conferring tensile strength|collagen-containing extracellular matrix",null,null,"R-HSA-1442490,R-HSA-1474228,R-HSA-1474244,R-HSA-1474290,R-HSA-1650814,R-HSA-8948216","Collagen degradation|Degradation of the extracellular matrix|Extracellular matrix organization|Collagen formation|Collagen biosynthesis and modifying enzymes|Collagen chain trimerization"]
["COMMD2",8.12189159632528,8.31524634704031,7.74843987959245,7.30646799528046,8.32855421283419,7.1129300731167,7.02617822266284,6.50453740758375,9.90178358907622,5.48904947455647,8.0636560283768,8.58977392906794,10.6662647577023,7.40233240469369,9.19563354271914,8.2888973803687,8.04023179029822,8.01454320765964,8.85528893843085,9.49431974391319,9.22245131438565,8.71205532927843,11.5264618471942,10.1164191016892,9.15190779865254,8.92372945397784,10.4580227230405,8.11573908164017,51122,"COMM domain containing 2","protein_coding",null,null,"GO:0005515,GO:0005737","protein binding|cytoplasm",null,null,"R-HSA-392499,R-HSA-597592,R-HSA-8951664","Metabolism of proteins|Post-translational protein modification|Neddylation"]
["COMT",48.3209520474785,47.6322336666098,52.8849648289677,50.2105280245979,47.3187228143353,54.5113156396499,51.8859996113822,57.1730987972997,48.3763166048972,67.6165746777366,56.7771796798886,51.8267443419493,50.8660455666726,58.2244745629404,50.0152847500743,55.3709677146493,47.9287673403125,52.0331128732696,47.7232494018168,47.9741596581473,49.9582070028226,49.342441158516,38.6587898045326,45.6949257337086,48.8335554935394,53.0483316209637,39.4931442258416,55.2479617883444,1312,"catechol-O-methyltransferase","protein_coding","hsa00140,hsa00350,hsa04728","Steroid hormone biosynthesis|Tyrosine metabolism|Dopaminergic synapse","GO:0000287,GO:0005515,GO:0005829,GO:0005886,GO:0006629,GO:0008168,GO:0008171,GO:0016020,GO:0016036,GO:0016206,GO:0030424,GO:0030425,GO:0032259,GO:0032502,GO:0042135,GO:0042417,GO:0042420,GO:0042424,GO:0043231,GO:0070062,GO:0102084,GO:0102938","magnesium ion binding|protein binding|cytosol|plasma membrane|lipid metabolic process|methyltransferase activity|O-methyltransferase activity|membrane|cellular response to phosphate starvation|catechol O-methyltransferase activity|axon|dendrite|methylation|developmental process|neurotransmitter catabolic process|dopamine metabolic process|dopamine catabolic process|catecholamine catabolic process|intracellular membrane-bounded organelle|extracellular exosome|L-dopa O-methyltransferase activity|orcinol O-methyltransferase activity","WP5316,WP5276,WP2436,WP702,WP4238,WP4657,WP4156,WP4288,WP704,WP4220,WP697,WP550","Primary ovarian insufficiency|Estrogen metabolism|Dopamine metabolism|Metapathway biotransformation Phase I and II|Flavan-3-ol metabolic pathway|22q11.2 copy number variation syndrome|Biosynthesis and regeneration of tetrahydrobiopterin and catabolism of phenylalanine|MTHFR deficiency|Methylation pathways|Neurotransmitter disorders|Estrogen metabolism|Biogenic amine synthesis","R-HSA-112311,R-HSA-112315,R-HSA-112316,R-HSA-1430728,R-HSA-156580,R-HSA-156581,R-HSA-1643685,R-HSA-211859,R-HSA-379397,R-HSA-379398,R-HSA-379401,R-HSA-5663205,R-HSA-9679191,R-HSA-9679506,R-HSA-9824446","Neurotransmitter clearance|Transmission across Chemical Synapses|Neuronal System|Metabolism|Phase II - Conjugation of compounds|Methylation|Disease|Biological oxidations|Enzymatic degradation of dopamine by COMT|Enzymatic degradation of Dopamine by monoamine oxidase|Dopamine clearance from the synaptic cleft|Infectious disease|Potential therapeutics for SARS|SARS-CoV Infections|Viral Infection Pathways"]
["COQ8B",8.53792474582401,9.68388913982022,13.4300941489799,11.5461121034209,9.71764278393481,10.9724409087431,13.6270403664962,11.4684197988929,9.57102326945742,11.812324929624,11.9178881190852,10.0377125775546,10.1314903194852,11.3446182265134,10.9664956401321,10.1928865872087,11.1204618466206,12.2720801452092,14.3823404640626,11.3600936527112,10.8764880200424,11.8518562376473,10.4220396694361,10.2718880829734,10.9242502687546,11.3371809068083,12.5748572182796,12.3680886615108,79934,"coenzyme Q8B","protein_coding",null,null,"GO:0004672,GO:0005524,GO:0005739,GO:0005829,GO:0005886,GO:0006468,GO:0006744,GO:0008289,GO:0016887,GO:0021692,GO:0031966","protein kinase activity|ATP binding|mitochondrion|cytosol|plasma membrane|protein phosphorylation|ubiquinone biosynthetic process|lipid binding|ATP hydrolysis activity|cerebellar Purkinje cell layer morphogenesis|mitochondrial membrane","WP4758","Nephrotic syndrome"]
["COSMOC",6.75045660713364,7.76570239890521,9.80610536411052,7.87388201603536,9.53783835458944,8.95172809096867,11.2344755007154,12.478608109967,4.31259568889968,4.17329540223736,5.96236196315876,5.1854174628247,5.50873173056589,6.00088704407833,6.91415920231409,6.01124121464199,10.4807234754201,9.70655907140067,12.6886061149633,8.42125262746437,8.56699041246375,8.02069725753013,9.41091239771458,8.0209596723882,7.95871931923136,10.7913705506786,10.8135929386822,10.6770699714184,101927809,"cell fate and sterol metabolism associated divergent transcript of MOCOS","non_coding"]
["COX6C",86.545170512287,63.5734953627716,107.816337470158,90.1210863230587,77.6845007110918,73.670880353064,108.285823714,109.957464091129,87.9604238388365,51.055432739994,95.2433056735797,93.1927123485211,83.9647127874913,86.1181388407759,97.948283033018,82.5547872145965,147.244186751283,126.351206427499,151.498886902244,114.296081468574,131.774347095857,128.833813325297,179.844639509722,144.02040203117,144.188108530446,141.730354578969,199.07444715882,149.835030112969,1345,"cytochrome c oxidase subunit 6C","protein_coding","hsa00190,hsa04260,hsa04714,hsa05208,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022,hsa05415,hsa04932","Oxidative phosphorylation|Cardiac muscle contraction|Thermogenesis|Chemical carcinogenesis - reactive oxygen species|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases|Diabetic cardiomyopathy|Non-alcoholic fatty liver disease","GO:0005515,GO:0005739,GO:0005743,GO:0005751,GO:0006091,GO:0006123,GO:0031966,GO:0045333","protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial respiratory chain complex IV|generation of precursor metabolites and energy|mitochondrial electron transport, cytochrome c to oxygen|mitochondrial membrane|cellular respiration","WP5413,WP5380,WP111,WP4352,WP4922,WP4396","IL-24 Signaling pathway|5q35 copy number variation|Electron transport chain: OXPHOS system in mitochondria|Ciliary landscape|Mitochondrial complex IV assembly|Nonalcoholic fatty liver disease","R-HSA-1428517,R-HSA-1430728,R-HSA-163200,R-HSA-212436,R-HSA-2262752,R-HSA-3700989,R-HSA-5628897,R-HSA-611105,R-HSA-73857,R-HSA-74160,R-HSA-8953897,R-HSA-9707564,R-HSA-9711123","The citric acid (TCA) cycle and respiratory electron transport|Metabolism|Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.|Generic Transcription Pathway|Cellular responses to stress|Transcriptional Regulation by TP53|TP53 Regulates Metabolic Genes|Respiratory electron transport|RNA Polymerase II Transcription|Gene expression (Transcription)|Cellular responses to stimuli|Cytoprotection by HMOX1|Cellular response to chemical stress"]
["CPEB4",3.43477938257063,2.83126298314768,1.87694385872557,1.46465993070565,3.38074130718989,2.46405341235145,1.93779658281294,1.67998274027228,3.31527320074893,1.76505064146412,1.39183726354953,2.25442883386681,3.89227125560442,2.17338785548471,3.06520978279236,3.69109380093736,1.54304614309234,1.34882150798034,1.07784031591447,1.95453864385505,2.06518582353862,1.64431930497098,2.26972632446225,2.15664503346222,1.77010572621635,1.16879594934531,1.63904727862749,1.32609356394635,80315,"cytoplasmic polyadenylation element binding protein 4","protein_coding","hsa04114,hsa04914","Oocyte meiosis|Progesterone-mediated oocyte maturation","GO:0000900,GO:0002931,GO:0003723,GO:0003730,GO:0005515,GO:0005634,GO:0005737,GO:0005783,GO:0006412,GO:0008135,GO:0014069,GO:0030425,GO:0030426,GO:0035235,GO:0036294,GO:0042149,GO:0043005,GO:0043022,GO:0043197,GO:0043524,GO:0045202,GO:0046872,GO:0048471,GO:0071230,GO:1990124,GO:2000766","mRNA regulatory element binding translation repressor activity|response to ischemia|RNA binding|mRNA 3'-UTR binding|protein binding|nucleus|cytoplasm|endoplasmic reticulum|translation|translation factor activity, RNA binding|postsynaptic density|dendrite|growth cone|ionotropic glutamate receptor signaling pathway|cellular response to decreased oxygen levels|cellular response to glucose starvation|neuron projection|ribosome binding|dendritic spine|negative regulation of neuron apoptotic process|synapse|metal ion binding|perinuclear region of cytoplasm|cellular response to amino acid stimulus|messenger ribonucleoprotein complex|negative regulation of cytoplasmic translation","WP2882,WP2880","Nuclear receptors meta-pathway|Glucocorticoid receptor pathway"]
["CPT1A",17.5865306075559,16.7539205631927,12.8671766451401,14.7565412520092,15.2235311226351,13.6852910886837,10.6144685009228,11.3767616708494,14.6913390693334,14.9607200451377,12.9496651088821,14.6806697348177,13.3220516458846,11.551397484161,10.9648074821257,12.1630827713036,10.3375624643428,10.7730531105857,8.1417805918384,11.514361750193,9.57622390046096,10.2028729689123,8.51538726990539,9.1898230975835,10.6553998041886,9.63170035053182,7.74684187261663,9.46923173242741,1374,"carnitine palmitoyltransferase 1A","protein_coding","hsa00071,hsa04152,hsa04922,hsa04920,hsa03320,hsa04714,hsa04936,hsa04931","Fatty acid degradation|AMPK signaling pathway|Glucagon signaling pathway|Adipocytokine signaling pathway|PPAR signaling pathway|Thermogenesis|Alcoholic liver disease|Insulin resistance","GO:0001676,GO:0004095,GO:0005739,GO:0005741,GO:0006006,GO:0006631,GO:0006635,GO:0006641,GO:0006853,GO:0009410,GO:0009437,GO:0010883,GO:0014070,GO:0016020,GO:0030855,GO:0031667,GO:0032000,GO:0042755,GO:0042802,GO:0043279,GO:0045471,GO:0050796,GO:0071398,GO:0097421,GO:1904772,GO:1990698","long-chain fatty acid metabolic process|carnitine O-palmitoyltransferase activity|mitochondrion|mitochondrial outer membrane|glucose metabolic process|fatty acid metabolic process|fatty acid beta-oxidation|triglyceride metabolic process|carnitine shuttle|response to xenobiotic stimulus|carnitine metabolic process|regulation of lipid storage|response to organic cyclic compound|membrane|epithelial cell differentiation|response to nutrient levels|positive regulation of fatty acid beta-oxidation|eating behavior|identical protein binding|response to alkaloid|response to ethanol|regulation of insulin secretion|cellular response to fatty acid|liver regeneration|response to tetrachloromethane|palmitoleoyltransferase activity","WP368,WP4321,WP4549,WP5323,WP2878,WP3934,WP706,WP4754,WP2882,WP3594,WP5123,WP1403,WP143,WP3942","Mitochondrial long chain fatty acid beta-oxidation|Thermogenesis|Fragile X syndrome|Fatty Acids and Lipoproteins Transport in Hepatocytes|PPAR-alpha pathway|Leptin and adiponectin|Sudden infant death syndrome (SIDS) susceptibility pathways|IL-18 signaling pathway|Nuclear receptors meta-pathway|Circadian rhythm genes|Mitochondrial fatty acid oxidation disorders|AMP-activated protein kinase signaling|Fatty acid beta-oxidation|PPAR signaling pathway","R-HSA-1368082,R-HSA-1430728,R-HSA-1430728,R-HSA-162582,R-HSA-1989781,R-HSA-200425,R-HSA-400206,R-HSA-400253,R-HSA-5362517,R-HSA-556833,R-HSA-556833,R-HSA-8978868,R-HSA-9006931","RORA activates gene expression|Metabolism|Metabolism|Signal Transduction|PPARA activates gene expression|Carnitine metabolism|Regulation of lipid metabolism by PPARalpha|Circadian Clock|Signaling by Retinoic Acid|Metabolism of lipids|Metabolism of lipids|Fatty acid metabolism|Signaling by Nuclear Receptors"]
["CRBN",6.55296896815458,5.81610664769129,6.55708117004657,6.58490213039097,7.06944463824522,6.48019451316361,7.49629437846126,6.28257015511092,8.15877986216857,4.97805980023811,6.63372198303087,6.83778781834365,9.14264210458818,7.02341126393691,8.55261652576514,7.90832142189139,8.07934344646756,6.68757687656046,9.93968643597165,7.67281380019847,9.76341943693974,6.81733813238782,14.5660530459288,10.3982686230302,8.62787023489712,7.77320916662829,13.0526146301409,7.9001520513588,51185,"cereblon","protein_coding",null,null,"GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0016020,GO:0016567,GO:0030177,GO:0031333,GO:0031334,GO:0031464,GO:0034766,GO:0035641,GO:0043161,GO:0044325,GO:0046872,GO:0048471","protein binding|nucleus|cytoplasm|cytosol|membrane|protein ubiquitination|positive regulation of Wnt signaling pathway|negative regulation of protein-containing complex assembly|positive regulation of protein-containing complex assembly|Cul4A-RING E3 ubiquitin ligase complex|negative regulation of monoatomic ion transmembrane transport|locomotory exploration behavior|proteasome-mediated ubiquitin-dependent protein catabolic process|transmembrane transporter binding|metal ion binding|perinuclear region of cytoplasm",null,null,"R-HSA-1643685,R-HSA-5663205,R-HSA-9679191,R-HSA-9679506,R-HSA-9824446","Disease|Infectious disease|Potential therapeutics for SARS|SARS-CoV Infections|Viral Infection Pathways"]
["CRLS1",6.49483156447654,5.69899210559925,6.94245929260755,6.27434660905138,5.71009281698217,5.73759809602258,7.80514304967417,6.78101360953309,7.20586450619196,5.05788524830283,6.35857022233587,6.6415581642956,6.98730199847582,6.41780712247091,7.48274694142661,6.48928756417786,8.41882275598005,7.56520977460074,10.8069800807018,7.82261633365638,8.95774215689365,8.22768391472311,12.4963441186908,9.89099013411455,8.61093805984021,9.29907911239126,13.3146540597077,8.96124700736119,54675,"cardiolipin synthase 1","protein_coding","hsa00564","Glycerophospholipid metabolism","GO:0003841,GO:0005739,GO:0005743,GO:0032049,GO:0036148,GO:0043337,GO:0047144,GO:0097068,GO:1905711","1-acylglycerol-3-phosphate O-acyltransferase activity|mitochondrion|mitochondrial inner membrane|cardiolipin biosynthetic process|phosphatidylglycerol acyl-chain remodeling|cardiolipin synthase (CMP-forming)|2-acylglycerol-3-phosphate O-acyltransferase activity|response to thyroxine|response to phosphatidylethanolamine","WP4722,WP2533","Glycerolipids and glycerophospholipids|Glycerophospholipid biosynthetic pathway","R-HSA-1430728,R-HSA-1482925,R-HSA-1483076,R-HSA-1483206,R-HSA-1483257,R-HSA-556833","Metabolism|Acyl chain remodelling of PG|Synthesis of CL|Glycerophospholipid biosynthesis|Phospholipid metabolism|Metabolism of lipids"]
["CRTAC1",0,0,0,0,0.00712289854526361,0,0.0272037916520102,0.0071479666360297,0.0146643041790255,0,0.00685526284911313,0.0146674917344912,0,0.00694955409318451,0.0135582095066065,0,0,0,0,0,0,0,7.19624629251207E-3,0,0.00722688418442668,0,0,0,55118,"cartilage acidic protein 1","protein_coding",null,null,"GO:0005509,GO:0005515,GO:0007413,GO:0070062","calcium ion binding|protein binding|axonal fasciculation|extracellular exosome"]
["CRYZL1",11.6900232528307,11.9695340818611,12.3845015529456,11.4702620236306,12.8570547433668,11.2468175657711,13.1572721524336,11.2812447952852,11.537999330646,7.19730577133239,10.2005882204637,9.77548855884532,12.2400487098009,10.1479058849138,11.8443008011108,10.3961710798782,17.3210940689552,13.1107476340157,15.7307450548003,12.5553011394175,16.6858061200459,14.3507347389787,20.2002596319886,18.3590297015328,16.8411094105181,14.6979680821625,19.8004672847727,15.0021873276345,9946,"crystallin zeta like 1","protein_coding",null,null,"GO:0003960,GO:0005829,GO:0050661,GO:1901661","NADPH:quinone reductase activity|cytosol|NADP binding|quinone metabolic process"]
["CSPG4",24.8393882004851,24.306809169977,20.9755796821923,22.8151351093184,26.3404788203848,23.771257861966,18.5636032610606,21.4909092133962,17.5343490792816,22.6989964314279,15.2960810137676,16.4356870565237,16.3736995501531,14.9639626240833,13.0698163052456,15.2457432406081,15.196792484308,18.9032934344971,12.4357177695969,16.700558515168,15.5356810175872,16.5605995372837,9.98019707083322,12.4942653299679,15.9189550629409,15.3401448871067,9.4459919485671,14.8597435069394,1464,"chondroitin sulfate proteoglycan 4","protein_coding",null,null,"GO:0001525,GO:0001726,GO:0005576,GO:0005654,GO:0005796,GO:0005886,GO:0005925,GO:0006929,GO:0008347,GO:0009986,GO:0015026,GO:0016324,GO:0019901,GO:0031258,GO:0035556,GO:0043202,GO:0043410,GO:0048008,GO:0048771,GO:0050731,GO:0062023,GO:0070062,GO:0097178","angiogenesis|ruffle|extracellular region|nucleoplasm|Golgi lumen|plasma membrane|focal adhesion|substrate-dependent cell migration|glial cell migration|cell surface|coreceptor activity|apical plasma membrane|protein kinase binding|lamellipodium membrane|intracellular signal transduction|lysosomal lumen|positive regulation of MAPK cascade|platelet-derived growth factor receptor signaling pathway|tissue remodeling|positive regulation of peptidyl-tyrosine phosphorylation|collagen-containing extracellular matrix|extracellular exosome|ruffle assembly","WP2431","Spinal cord injury","R-HSA-1430728,R-HSA-1630316,R-HSA-1638091,R-HSA-1643685,R-HSA-1793185,R-HSA-1971475,R-HSA-2022870,R-HSA-2022923,R-HSA-2024101,R-HSA-3560782,R-HSA-3560783,R-HSA-3560801,R-HSA-3595172,R-HSA-3595174,R-HSA-3595177,R-HSA-3781865,R-HSA-4420332,R-HSA-5668914,R-HSA-71387","Metabolism|Glycosaminoglycan metabolism|Heparan sulfate/heparin (HS-GAG) metabolism|Disease|Chondroitin sulfate/dermatan sulfate metabolism|A tetrasaccharide linker sequence is required for GAG synthesis|Chondroitin sulfate biosynthesis|Dermatan sulfate biosynthesis|CS/DS degradation|Diseases associated with glycosaminoglycan metabolism|Defective B4GALT7 causes EDS, progeroid type|Defective B3GAT3 causes JDSSDHD|Defective CHST3 causes SEDCJD|Defective CHST14 causes EDS, musculocontractural type|Defective CHSY1 causes TPBS|Diseases of glycosylation|Defective B3GALT6 causes EDSP2 and SEMDJL1|Diseases of metabolism|Metabolism of carbohydrates"]
["CSTA",0.0362314720903805,0.103386423629324,0.0340154028160616,0.104244271314446,0,0.0340231986788244,0.03380363626651,0.0355284685753196,0,0,0.0340736048602424,0.0364518712595085,0.0689116174067488,0.172711364493255,0.0673901327357944,0.0343529391762727,0,0,0,0,0,0.0344393496018621,0.0357684392334807,0,0.143682890935536,0.0344264153142197,0,0.0340617758836869,1475,"cystatin A","protein_coding",null,null,"GO:0001533,GO:0002020,GO:0004869,GO:0005515,GO:0005615,GO:0005654,GO:0005737,GO:0005829,GO:0010466,GO:0018149,GO:0030216,GO:0045861,GO:0098609,GO:1904090","cornified envelope|protease binding|cysteine-type endopeptidase inhibitor activity|protein binding|extracellular space|nucleoplasm|cytoplasm|cytosol|negative regulation of peptidase activity|peptide cross-linking|keratinocyte differentiation|negative regulation of proteolysis|cell-cell adhesion|peptidase inhibitor complex","WP5346","8p23.1 copy number variation syndrome","R-HSA-1266738,R-HSA-6805567,R-HSA-6809371","Developmental Biology|Keratinization|Formation of the cornified envelope"]
["CTAGE8",0.0206166082105109,0.00980490747995125,0.0387112194189673,0.0395450543571438,0.0604370450945732,0.00968002287458714,0.00961755463949654,0.0606497452084998,0,0,0,0,0,0,0,0,0,0,0,0,0.0194590210469789,0.0489921149211959,0.010176565502757,0,0.0204397841024932,0.0391789720746148,0,0,100142659,"CTAGE family member 8","protein_coding",null,null,"GO:0005789,GO:0006888,GO:0009306,GO:0035459,GO:0070971","endoplasmic reticulum membrane|endoplasmic reticulum to Golgi vesicle-mediated transport|protein secretion|vesicle cargo loading|endoplasmic reticulum exit site"]
["CTNNAL1",31.860246499429,27.2182916067857,26.6357517785969,27.505348758883,26.7458768764207,23.774884911037,25.745404325826,24.4407822386537,22.2029081436711,15.6142582813473,17.8975979663221,20.6344635337487,17.9162590714187,14.7969609559566,16.4126620511562,14.5343028818621,39.1512976542782,34.6663157068025,43.2889424622379,38.4528614557505,37.9129921039703,38.0601837626868,47.0273388872612,42.6210816656367,37.0395667764809,38.00545827017,42.2775202289006,37.7529217627951,8727,"catenin alpha like 1","protein_coding",null,null,"GO:0005515,GO:0005829,GO:0005856,GO:0005886,GO:0007155,GO:0007266,GO:0045296,GO:0051015","protein binding|cytosol|cytoskeleton|plasma membrane|cell adhesion|Rho protein signal transduction|cadherin binding|actin filament binding"]
["CTXN2",0,0,0,0,0,0,0.00742761529305477,0,0.00800776681246846,0.0306701598871176,0,0,0,0.007589914659361,0.00740375941456453,0.00754831268374096,0,0,0.00735779947324959,0,0,0,0.0157186761900234,0,0,0,0.00770379042969397,0.00748433587048524,399697,"cortexin 2","protein_coding",null,null,"GO:0016020","membrane"]
["CUL2",12.3851510074249,10.7093940533134,10.6657967482851,9.38767225248292,11.3836462559593,10.8492202941165,10.7839387330619,8.83261124763634,10.2539491699542,7.40035181031689,9.0480518427828,9.72040755851865,10.7894199788654,9.54965490071078,10.7870364791788,9.94452632043269,11.6881454593371,10.7978750232452,13.2887672740469,12.446302419279,12.9535023652325,10.818012037045,16.3275286873458,13.7598569677445,12.2688698442491,10.6982919371948,13.9381933549652,10.718481450005,8453,"cullin 2","protein_coding","hsa04120,hsa04066,hsa05200,hsa05211","Ubiquitin mediated proteolysis|HIF-1 signaling pathway|Pathways in cancer|Renal cell carcinoma","GO:0000082,GO:0004842,GO:0005515,GO:0005654,GO:0005730,GO:0005829,GO:0016567,GO:0019005,GO:0030674,GO:0030891,GO:0031146,GO:0031462,GO:0031625,GO:0044877,GO:0097193,GO:0140627,GO:0160072","G1/S transition of mitotic cell cycle|ubiquitin-protein transferase activity|protein binding|nucleoplasm|nucleolus|cytosol|protein ubiquitination|SCF ubiquitin ligase complex|protein-macromolecule adaptor activity|VCB complex|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|Cul2-RING ubiquitin ligase complex|ubiquitin protein ligase binding|protein-containing complex binding|intrinsic apoptotic signaling pathway|ubiquitin-dependent protein catabolic process via the C-end degron rule pathway|ubiquitin ligase complex scaffold activity","WP4860,WP4241","Hijack of ubiquitination by SARS-CoV-2|Type 2 papillary renal cell carcinoma","R-HSA-1234174,R-HSA-1234174,R-HSA-1234176,R-HSA-1234176,R-HSA-1266738,R-HSA-1280218,R-HSA-168256,R-HSA-2262752,R-HSA-2262752,R-HSA-376176,R-HSA-392499,R-HSA-422475,R-HSA-597592,R-HSA-8951664,R-HSA-8953897,R-HSA-8953897,R-HSA-9010553,R-HSA-9675108,R-HSA-983168,R-HSA-983169","Cellular response to hypoxia|Cellular response to hypoxia|Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha|Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha|Developmental Biology|Adaptive Immune System|Immune System|Cellular responses to stress|Cellular responses to stress|Signaling by ROBO receptors|Metabolism of proteins|Axon guidance|Post-translational protein modification|Neddylation|Cellular responses to stimuli|Cellular responses to stimuli|Regulation of expression of SLITs and ROBOs|Nervous system development|Antigen processing: Ubiquitination & Proteasome degradation|Class I MHC mediated antigen processing & presentation"]
["CXCL13",0,0,0,0,0.0218230976142376,0,0,0,0,0.0215097683052569,0,0.0224690904863913,0.0212387089273492,0.021292005829823,0,0,0,0,0,0,0,0,0.0220478200411844,0,0,0,0,0,10563,"C-X-C motif chemokine ligand 13","protein_coding","hsa04060,hsa04061,hsa04062","Cytokine-cytokine receptor interaction|Viral protein interaction with cytokine and cytokine receptor|Chemokine signaling pathway","GO:0002467,GO:0002518,GO:0002544,GO:0002920,GO:0005576,GO:0005615,GO:0006954,GO:0006955,GO:0007166,GO:0007204,GO:0007267,GO:0008009,GO:0008201,GO:0010820,GO:0017134,GO:0030593,GO:0031724,GO:0031735,GO:0033625,GO:0033634,GO:0035754,GO:0035768,GO:0042742,GO:0045236,GO:0045765,GO:0048018,GO:0048248,GO:0061844,GO:0070098,GO:0071222,GO:0090630,GO:2000545","germinal center formation|lymphocyte chemotaxis across high endothelial venule|chronic inflammatory response|regulation of humoral immune response|extracellular region|extracellular space|inflammatory response|immune response|cell surface receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|cell-cell signaling|chemokine activity|heparin binding|positive regulation of T cell chemotaxis|fibroblast growth factor binding|neutrophil chemotaxis|CXCR5 chemokine receptor binding|CCR10 chemokine receptor binding|positive regulation of integrin activation|positive regulation of cell-cell adhesion mediated by integrin|B cell chemotaxis|endothelial cell chemotaxis to fibroblast growth factor|defense response to bacterium|CXCR chemokine receptor binding|regulation of angiogenesis|receptor ligand activity|CXCR3 chemokine receptor binding|antimicrobial humoral immune response mediated by antimicrobial peptide|chemokine-mediated signaling pathway|cellular response to lipopolysaccharide|activation of GTPase activity|negative regulation of endothelial cell chemotaxis to fibroblast growth factor","WP5115,WP5095,WP5218,WP5222,WP5039,WP3929,WP2328","Network map of SARS-CoV-2 signaling pathway|Overview of proinflammatory and profibrotic mediators|Extrafollicular and follicular B cell activation by SARS-CoV-2|2q13 copy number variation syndrome|SARS-CoV-2 innate immunity evasion and cell-specific immune response|Chemokine signaling pathway|Allograft rejection","R-HSA-162582,R-HSA-372790,R-HSA-373076,R-HSA-375276,R-HSA-380108,R-HSA-388396,R-HSA-418594,R-HSA-500792","Signal Transduction|Signaling by GPCR|Class A/1 (Rhodopsin-like receptors)|Peptide ligand-binding receptors|Chemokine receptors bind chemokines|GPCR downstream signalling|G alpha (i) signalling events|GPCR ligand binding"]
["CYB5D1",4.82878604815905,5.38664305905221,5.26604062444219,4.72000372747808,4.98272170291029,4.65055876833651,5.06025611303038,5.1820852806265,4.78716188909235,4.10009228426174,4.20696222621834,4.66383357129395,4.68030166442328,4.4121442163718,5.15896672204062,4.17552148061729,4.74657919482624,4.63947323995585,5.01269226985641,4.33885189293369,4.29513689915357,4.20805617869563,5.11030426744209,4.65720658841651,5.13972109088581,4.26520492673713,4.68768029969325,4.5178274296767,124637,"cytochrome b5 domain containing 1","protein_coding",null,null,"GO:0003341,GO:0003356,GO:0005737,GO:0005856,GO:0042995,GO:0046872","cilium movement|regulation of cilium beat frequency|cytoplasm|cytoskeleton|cell projection|metal ion binding"]
["CYP27A1",19.6947315296037,23.9186662673868,26.677504070158,25.6062576124047,21.6404886627414,26.7603582561315,28.3412965806416,27.9214064669866,27.243470052266,34.2378406664509,34.0462161159286,30.3619302213673,26.6565297282029,34.5256375554447,30.9862690532698,31.6798073929555,17.8240916977039,20.923321800309,19.9394390049155,18.6133070369896,18.0049037725957,18.4764351289747,17.8640814742529,16.3213850033487,17.5813347369341,21.3314359060363,17.3523658859392,20.1945468660597,1593,"cytochrome P450 family 27 subfamily A member 1","protein_coding","hsa00120,hsa03320,hsa04979","Primary bile acid biosynthesis|PPAR signaling pathway|Cholesterol metabolism","GO:0005506,GO:0005739,GO:0005743,GO:0005759,GO:0006699,GO:0006707,GO:0008203,GO:0008395,GO:0016125,GO:0020037,GO:0030343,GO:0031073,GO:0036378,GO:0047103,GO:0047748,GO:0047749","iron ion binding|mitochondrion|mitochondrial inner membrane|mitochondrial matrix|bile acid biosynthetic process|cholesterol catabolic process|cholesterol metabolic process|steroid hydroxylase activity|sterol metabolic process|heme binding|vitamin D3 25-hydroxylase activity|cholesterol 26-hydroxylase activity|calcitriol biosynthetic process from calciol|3-alpha,7-alpha,12-alpha-trihydroxycholestan-26-al 26-oxidoreductase activity|cholestanetetraol 26-dehydrogenase activity|cholestanetriol 26-monooxygenase activity","WP4698,WP4718,WP702,WP5064,WP1531,WP43,WP5304,WP5329,WP4545,WP5176,WP3942","Vitamin D-sensitive calcium signaling in depression|Cholesterol metabolism with Bloch and Kandutsch-Russell pathways|Metapathway biotransformation Phase I and II|7-oxo-C and 7-beta-HC pathways|Vitamin D metabolism|Oxidation by cytochrome P450|Cholesterol metabolism|Cholesterol biosynthesis pathway in hepatocytes|Oxysterols derived from cholesterol|Disorders of bile acid synthesis and biliary transport|PPAR signaling pathway","R-HSA-1430728,R-HSA-1643685,R-HSA-192105,R-HSA-193368,R-HSA-193775,R-HSA-193807,R-HSA-194068,R-HSA-211859,R-HSA-211897,R-HSA-211945,R-HSA-211976,R-HSA-556833,R-HSA-5578996,R-HSA-5579029,R-HSA-5668914,R-HSA-8957322","Metabolism|Disease|Synthesis of bile acids and bile salts|Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol|Synthesis of bile acids and bile salts via 24-hydroxycholesterol|Synthesis of bile acids and bile salts via 27-hydroxycholesterol|Bile acid and bile salt metabolism|Biological oxidations|Cytochrome P450 - arranged by substrate type|Phase I - Functionalization of compounds|Endogenous sterols|Metabolism of lipids|Defective CYP27A1 causes CTX|Metabolic disorders of biological oxidation enzymes|Diseases of metabolism|Metabolism of steroids"]
["CYP4F2",0,0,0,0.0656990579059283,0,0,0,0.0111957562981947,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,8529,"cytochrome P450 family 4 subfamily F member 2","protein_coding","hsa00590","Arachidonic acid metabolism","GO:0000038,GO:0001676,GO:0003091,GO:0003095,GO:0004497,GO:0005506,GO:0005515,GO:0005737,GO:0005789,GO:0006690,GO:0006691,GO:0006805,GO:0007596,GO:0008217,GO:0008392,GO:0010430,GO:0016324,GO:0016709,GO:0018685,GO:0019369,GO:0019373,GO:0020037,GO:0032304,GO:0032305,GO:0036101,GO:0042360,GO:0042361,GO:0042376,GO:0042377,GO:0043231,GO:0050051,GO:0052869,GO:0052871,GO:0052872,GO:0055078,GO:0070330,GO:0097258,GO:0097259,GO:0097267,GO:0102033","very long-chain fatty acid metabolic process|long-chain fatty acid metabolic process|renal water homeostasis|pressure natriuresis|monooxygenase activity|iron ion binding|protein binding|cytoplasm|endoplasmic reticulum membrane|icosanoid metabolic process|leukotriene metabolic process|xenobiotic metabolic process|blood coagulation|regulation of blood pressure|arachidonic acid epoxygenase activity|fatty acid omega-oxidation|apical plasma membrane|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen|alkane 1-monooxygenase activity|arachidonic acid metabolic process|epoxygenase P450 pathway|heme binding|negative regulation of icosanoid secretion|positive regulation of icosanoid secretion|leukotriene B4 catabolic process|vitamin E metabolic process|menaquinone catabolic process|phylloquinone catabolic process|vitamin K catabolic process|intracellular membrane-bounded organelle|leukotriene-B4 20-monooxygenase activity|arachidonic acid omega-hydroxylase activity|alpha-tocopherol omega-hydroxylase activity|tocotrienol omega-hydroxylase activity|sodium ion homeostasis|aromatase activity|20-hydroxy-leukotriene B4 omega oxidase activity|20-aldehyde-leukotriene B4 20-monooxygenase activity|omega-hydroxylase P450 pathway|long-chain fatty acid omega-hydroxylase activity","WP702,WP4719,WP43,WP4721,WP4720","Metapathway biotransformation Phase I and II|Eicosanoid metabolism via cyclooxygenases (COX)|Oxidation by cytochrome P450|Eicosanoid metabolism via lipooxygenases (LOX)|Eicosanoid metabolism via cytochrome P450 monooxygenases pathway","R-HSA-1430728,R-HSA-211859,R-HSA-211897,R-HSA-211935,R-HSA-211945,R-HSA-211958,R-HSA-211979,R-HSA-2142691,R-HSA-2142753,R-HSA-2142816,R-HSA-556833,R-HSA-8978868","Metabolism|Biological oxidations|Cytochrome P450 - arranged by substrate type|Fatty acids|Phase I - Functionalization of compounds|Miscellaneous substrates|Eicosanoids|Synthesis of Leukotrienes (LT) and Eoxins (EX)|Arachidonic acid metabolism|Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)|Metabolism of lipids|Fatty acid metabolism"]
["CYSRT1",1.45040003234247,0.605665347875729,0.498178340455706,0.712472657487714,0.656783592634268,0.697609522516998,0.627097378298406,0.832541121890955,0.284664550414889,0.851781179279694,0.665374331129143,0.569452854951692,0.571912163359947,0.53962101914113,0.131596479673047,0.503121786361159,0.442149586870343,0.327318065228677,0.35964383094574,0.40821524793565,0.701175945403445,0.94152300643831,0.838164371329438,0.898586077033516,0.771588437937292,0.57142427938878,0.342323286022884,0.465600338063625,375791,"cysteine rich tail 1","protein_coding",null,null,"GO:0001533,GO:0005515,GO:0042802,GO:0051702,GO:0061436,GO:0070062","cornified envelope|protein binding|identical protein binding|biological process involved in interaction with symbiont|establishment of skin barrier|extracellular exosome"]
["DAO",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.0141920752964873,0,1610,"D-amino acid oxidase","protein_coding","hsa00260,hsa00330,hsa00470,hsa04146","Glycine, serine and threonine metabolism|Arginine and proline metabolism|D-Amino acid metabolism|Peroxisome","GO:0003884,GO:0005515,GO:0005737,GO:0005741,GO:0005777,GO:0005778,GO:0005782,GO:0005829,GO:0006562,GO:0036088,GO:0042416,GO:0042802,GO:0055130,GO:0070178,GO:0071949","D-amino-acid oxidase activity|protein binding|cytoplasm|mitochondrial outer membrane|peroxisome|peroxisomal membrane|peroxisomal matrix|cytosol|proline catabolic process|D-serine catabolic process|dopamine biosynthetic process|identical protein binding|D-alanine catabolic process|D-serine metabolic process|FAD binding","WP5083,WP5166","Neuroinflammation and glutamatergic signaling|Glyoxylate metabolism","R-HSA-1430728,R-HSA-389661,R-HSA-71291,R-HSA-9033241,R-HSA-9033241,R-HSA-9609507,R-HSA-9609507","Metabolism|Glyoxylate metabolism and glycine degradation|Metabolism of amino acids and derivatives|Peroxisomal protein import|Peroxisomal protein import|Protein localization|Protein localization"]
["DCAF12",8.32068639066504,8.17482564874414,7.06024728666463,7.22579254333407,7.45135712397446,7.40473841483249,7.11456036602236,6.52050587318984,8.19291122045874,7.66222322486488,8.06284981025289,9.08480520738672,7.67250711251155,7.330268008615,8.33896280680977,7.06373027838574,8.43864551052962,7.76380716375569,6.45064547078004,8.19716208598888,8.76807825867095,8.62327583383454,7.45876775663652,8.00560305514619,8.50689545363898,7.77271157534594,8.06536489366978,7.0962772471406,25853,"DDB1 and CUL4 associated factor 12","protein_coding",null,null,"GO:0005515,GO:0005634,GO:0005737,GO:0005813,GO:0005829,GO:0010506,GO:0016567,GO:0042110,GO:0080008,GO:0140627,GO:1990756","protein binding|nucleus|cytoplasm|centrosome|cytosol|regulation of autophagy|protein ubiquitination|T cell activation|Cul4-RING E3 ubiquitin ligase complex|ubiquitin-dependent protein catabolic process via the C-end degron rule pathway|ubiquitin ligase-substrate adaptor activity"]
["DCLK2",2.83381367171277,3.93221752965421,3.93051180210201,3.36648339393502,3.1394340969137,3.16484191526113,3.63403348374764,2.91033721297842,3.35482991569422,3.33584262699553,3.16953070414444,3.68994179202677,2.72265730966417,2.3570337961317,2.73303941301506,2.44915724183129,3.8177198941402,4.97430000387887,4.26811575622044,4.67072239826523,4.27621773841763,4.79424352796331,3.17751866145787,4.06169160192991,4.09864537296841,4.02786825145526,3.90457361049126,4.06194966294183,166614,"doublecortin like kinase 2","protein_coding",null,null,"GO:0000226,GO:0004674,GO:0005515,GO:0005524,GO:0005737,GO:0005856,GO:0008017,GO:0016310,GO:0021766,GO:0021860,GO:0034504,GO:0035556,GO:0106310,GO:1900181","microtubule cytoskeleton organization|protein serine/threonine kinase activity|protein binding|ATP binding|cytoplasm|cytoskeleton|microtubule binding|phosphorylation|hippocampus development|pyramidal neuron development|protein localization to nucleus|intracellular signal transduction|protein serine kinase activity|negative regulation of protein localization to nucleus"]
["DCST1-AS1",0.308154882928745,0.111659588721056,0.27553031785683,0.337758248700918,0.129049705706839,0.179135752651927,0.177979733244248,0.259007757844682,0.118080777036551,0.268526682931114,0.124200793763845,0.162396360581283,0.15350372260665,0.139899025784411,0.177408101203212,0.111305766999006,0.211623038311964,0.162928491478008,0.230555064387149,0.282217400586976,0.221601916332498,0.167378613633873,0.376649258863609,0.329731158370449,0.232770976278801,0.25097362759283,0.454393631267393,0.372473028824987,100505666,"DCST1 antisense RNA 1","non_coding"]
["DDAH2",41.4610182467515,39.8518637027707,45.9526591223116,47.2078433207033,40.3858881103469,45.334120093736,44.4301407887989,50.2387517132863,46.420967971486,61.0415384003376,61.1239604956773,54.2403844341487,45.9243995004483,54.8421564530284,43.5290015234887,46.9609689503223,47.885114464846,50.5165831996348,55.7088135164642,48.5943753681149,48.6723363246966,53.7928128251271,44.0221949941064,43.3945040442504,45.942196848179,52.5272330439691,48.8865393387682,55.6263579627619,23564,"dimethylarginine dimethylaminohydrolase 2","protein_coding",null,null,"GO:0000052,GO:0003824,GO:0005515,GO:0005739,GO:0005829,GO:0006525,GO:0006527,GO:0006809,GO:0007263,GO:0016403,GO:0016597,GO:0043066,GO:0045429,GO:0046209,GO:0070062","citrulline metabolic process|catalytic activity|protein binding|mitochondrion|cytosol|arginine metabolic process|arginine catabolic process|nitric oxide biosynthetic process|nitric oxide mediated signal transduction|dimethylargininase activity|amino acid binding|negative regulation of apoptotic process|positive regulation of nitric oxide biosynthetic process|nitric oxide metabolic process|extracellular exosome","WP4947","Nitric oxide metabolism in cystic fibrosis","R-HSA-1430728,R-HSA-202131,R-HSA-203615","Metabolism|Metabolism of nitric oxide: NOS3 activation and regulation|eNOS activation"]
["DDX23",27.2459779911502,27.2698838719383,25.1908712751783,26.8847768618973,23.9458898367135,25.2666137608714,22.9948612785804,24.5497353178729,27.7638424311052,31.5518374978406,27.9979546098308,28.0697321165665,23.0448406460792,23.6314976669439,23.6755444829469,22.5443062462548,26.2510752970557,29.3615764663512,27.4155721148169,27.2113826958529,26.6460395468471,26.543599845844,23.9554507901225,24.8634148059249,27.1846617533171,27.1000173721038,23.1368486893727,28.5097064146459,9416,"DEAD-box helicase 23","protein_coding","hsa03040","Spliceosome","GO:0000354,GO:0000375,GO:0000398,GO:0000785,GO:0003723,GO:0003724,GO:0004386,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005682,GO:0005730,GO:0008380,GO:0016887,GO:0046540,GO:0062176,GO:0070062,GO:0071013","cis assembly of pre-catalytic spliceosome|RNA splicing, via transesterification reactions|mRNA splicing, via spliceosome|chromatin|RNA binding|RNA helicase activity|helicase activity|protein binding|ATP binding|nucleus|nucleoplasm|U5 snRNP|nucleolus|RNA splicing|ATP hydrolysis activity|U4/U6 x U5 tri-snRNP complex|R-loop processing|extracellular exosome|catalytic step 2 spliceosome",null,null,"R-HSA-72163,R-HSA-72165,R-HSA-72172,R-HSA-72203,R-HSA-8953854","mRNA Splicing - Major Pathway|mRNA Splicing - Minor Pathway|mRNA Splicing|Processing of Capped Intron-Containing Pre-mRNA|Metabolism of RNA"]
["DDX4",0,0,0,0,0,0.00783207296319473,0,0,0,0,0.0156873527326858,0,0,0,0,0.0316319142910234,0,0.0077170905230276,0,0.0080203181447753,0,0,0.0329352955318189,0.0162967105554917,0.0330755169727844,0,0,0,54514,"DEAD-box helicase 4","protein_coding",null,null,"GO:0003723,GO:0003724,GO:0005524,GO:0005634,GO:0005737,GO:0007140,GO:0007141,GO:0007276,GO:0007283,GO:0016887,GO:0030154,GO:0030317,GO:0034587,GO:0043186,GO:0048471,GO:0071546,GO:0071547,GO:0140693,GO:0141006,GO:0141007","RNA binding|RNA helicase activity|ATP binding|nucleus|cytoplasm|male meiotic nuclear division|male meiosis I|gamete generation|spermatogenesis|ATP hydrolysis activity|cell differentiation|flagellated sperm motility|piRNA processing|P granule|perinuclear region of cytoplasm|pi-body|piP-body|molecular condensate scaffold activity|piRNA-mediated retrotransposon silencing by heterochromatin formation|siRNA-mediated retrotransposon silencing by heterochromatin formation","WP4673","Male infertility","R-HSA-162582,R-HSA-194315,R-HSA-211000,R-HSA-5601884,R-HSA-74160,R-HSA-9012999,R-HSA-9696264,R-HSA-9716542","Signal Transduction|Signaling by Rho GTPases|Gene Silencing by RNA|PIWI-interacting RNA (piRNA) biogenesis|Gene expression (Transcription)|RHO GTPase cycle|RND3 GTPase cycle|Signaling by Rho GTPases, Miro GTPases and RHOBTB3"]
["DEGS1",83.5114119052629,69.5923045009728,54.2890937640637,58.1332508766988,75.1643200381445,67.1429728480494,59.1867402008598,63.0558726680752,74.64633096366,51.8812560491831,52.1504411768862,65.3170086229329,76.0284021651159,61.4985611789389,61.8413692158664,63.6458924879932,67.8571700229481,65.2936042884514,63.4010867752111,68.8432791158761,68.4309109770586,64.6825295385923,65.5911700498976,68.6348644796383,69.9176412534651,59.4223195237411,63.3680247316469,58.9938021763219,8560,"delta 4-desaturase%2C sphingolipid 1","protein_coding","hsa00600,hsa04071","Sphingolipid metabolism|Sphingolipid signaling pathway","GO:0005515,GO:0005739,GO:0005783,GO:0005789,GO:0005886,GO:0006636,GO:0009055,GO:0016020,GO:0022900,GO:0030148,GO:0031966,GO:0035579,GO:0042284,GO:0043217,GO:0046513,GO:0050251","protein binding|mitochondrion|endoplasmic reticulum|endoplasmic reticulum membrane|plasma membrane|unsaturated fatty acid biosynthetic process|electron transfer activity|membrane|electron transport chain|sphingolipid biosynthetic process|mitochondrial membrane|specific granule membrane|sphingolipid delta-4 desaturase activity|myelin maintenance|ceramide biosynthetic process|retinol isomerase activity","WP4726,WP5121,WP4725","Sphingolipid metabolism: integrated pathway|Sphingolipid metabolism in senescence|Sphingolipid metabolism overview","R-HSA-1430728,R-HSA-1660661,R-HSA-168249,R-HSA-168256,R-HSA-428157,R-HSA-556833,R-HSA-6798695","Metabolism|Sphingolipid de novo biosynthesis|Innate Immune System|Immune System|Sphingolipid metabolism|Metabolism of lipids|Neutrophil degranulation"]
["DEPDC5",1.4775514223719,1.51616671801158,1.2436769716531,1.37517432680939,1.28733000310237,1.03207836705112,1.01183634452821,1.29186058923365,1.1274745396951,1.64038772528693,1.32794595142647,1.40232666655049,0.986365556563185,0.940266130811072,1.13381373586265,0.969618317260467,1.11966596319972,0.973151474126216,1.00232559563846,1.44884172444718,1.03735471118068,1.25225882942761,1.05986999364983,1.29775236317689,1.30973152830911,0.95440229867465,1.0600236739406,1.2761646481752,9681,"DEP domain containing 5%2C GATOR1 subcomplex subunit","protein_coding","hsa04150","mTOR signaling pathway","GO:0005096,GO:0005764,GO:0005765,GO:0005829,GO:0010508,GO:0031267,GO:0032007,GO:0034198,GO:0035556,GO:0044877,GO:0048471,GO:1904262,GO:1990130","GTPase activator activity|lysosome|lysosomal membrane|cytosol|positive regulation of autophagy|small GTPase binding|negative regulation of TOR signaling|cellular response to amino acid starvation|intracellular signal transduction|protein-containing complex binding|perinuclear region of cytoplasm|negative regulation of TORC1 signaling|GATOR1 complex","WP4657","22q11.2 copy number variation syndrome","R-HSA-2262752,R-HSA-8953897,R-HSA-9639288,R-HSA-9711097","Cellular responses to stress|Cellular responses to stimuli|Amino acids regulate mTORC1|Cellular response to starvation"]
["DGKA",9.70684509922055,9.8342866344075,8.43990010147803,10.4723265547814,8.60604277783311,8.90096246045561,7.31080683663959,9.21165980011475,8.02609462507141,8.89059325942786,9.067418868608,8.97884961189233,7.96641628845806,7.89939595344956,7.39039146588517,6.92894213870657,8.0037999645479,8.0404356827997,6.88661204492663,7.99277557702298,7.08210718060041,7.89444840537428,6.57087421627414,6.40076461401764,8.16938872805525,6.71457466632574,6.1758763416324,8.05304403683348,1606,"diacylglycerol kinase alpha","protein_coding","hsa00561,hsa00564,hsa04070,hsa04072,hsa05231","Glycerolipid metabolism|Glycerophospholipid metabolism|Phosphatidylinositol signaling system|Phospholipase D signaling pathway|Choline metabolism in cancer","GO:0004143,GO:0005509,GO:0005524,GO:0005543,GO:0005829,GO:0005886,GO:0006654,GO:0007205,GO:0008289,GO:0016020,GO:0016301,GO:0030168,GO:0035556,GO:0046339,GO:0046486,GO:0046834","ATP-dependent diacylglycerol kinase activity|calcium ion binding|ATP binding|phospholipid binding|cytosol|plasma membrane|phosphatidic acid biosynthetic process|protein kinase C-activating G protein-coupled receptor signaling pathway|lipid binding|membrane|kinase activity|platelet activation|intracellular signal transduction|diacylglycerol metabolic process|glycerolipid metabolic process|lipid phosphorylation","WP5072","Modulators of TCR signaling and T cell activation","R-HSA-109582,R-HSA-114508,R-HSA-162582,R-HSA-372790,R-HSA-388396,R-HSA-416476,R-HSA-76002","Hemostasis|Effects of PIP2 hydrolysis|Signal Transduction|Signaling by GPCR|GPCR downstream signalling|G alpha (q) signalling events|Platelet activation, signaling and aggregation"]
["DHRS4L2",7.20785755203239,6.93947655647615,8.40372710529161,9.32940904668074,6.41333397365891,7.04368968822132,9.13050912791595,8.92119845926276,6.57227016220115,8.98803203772365,9.97497374978192,9.16780410816318,6.77101583380485,8.11488100666439,7.83410293053609,7.44532744373409,8.57788683042967,10.1122070008354,10.9808998979995,10.3264037080373,9.85903463233344,11.8366547218574,9.19839845122573,8.95978975288276,9.16493813996751,12.820546743082,10.2355406701899,12.5194797733879,317749,"dehydrogenase/reductase 4 like 2","protein_coding","hsa00830","Retinol metabolism","GO:0004090,GO:0005576,GO:0005777,GO:0042574","carbonyl reductase (NADPH) activity|extracellular region|peroxisome|retinal metabolic process"]
["DHX37",6.24017088881292,6.99458840534494,8.3892417517051,7.1477887923617,5.81752906462487,6.37749204388546,7.915276970007,6.78938136171114,5.85535769712295,7.61348146297223,8.68872743125769,6.32804485065068,5.27905266401589,6.1909924992046,6.72611405798829,6.14137820611403,5.25755295443825,6.92653220094834,7.16836547773156,6.76931908946378,6.65463700494991,5.96295153499138,6.39443140652533,5.48790561524957,5.23023352807923,6.31688816165603,5.12098834747363,6.34844632727857,57647,"DEAH-box helicase 37","protein_coding",null,null,"GO:0000462,GO:0003723,GO:0003724,GO:0004386,GO:0005515,GO:0005524,GO:0005622,GO:0005654,GO:0005730,GO:0005737,GO:0007420,GO:0016887,GO:0031965,GO:0032040,GO:0034511,GO:0042254,GO:0042255,GO:0042274,GO:2000020","maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|RNA binding|RNA helicase activity|helicase activity|protein binding|ATP binding|intracellular anatomical structure|nucleoplasm|nucleolus|cytoplasm|brain development|ATP hydrolysis activity|nuclear membrane|small-subunit processome|U3 snoRNA binding|ribosome biogenesis|ribosome assembly|ribosomal small subunit biogenesis|positive regulation of male gonad development",null,null,"R-HSA-6790901,R-HSA-6791226,R-HSA-72312,R-HSA-72312,R-HSA-8868773,R-HSA-8868773,R-HSA-8953854,R-HSA-8953854","rRNA modification in the nucleus and cytosol|Major pathway of rRNA processing in the nucleolus and cytosol|rRNA processing|rRNA processing|rRNA processing in the nucleus and cytosol|rRNA processing in the nucleus and cytosol|Metabolism of RNA|Metabolism of RNA"]
["DINOL",0.226761011442633,0.0269609180442403,0,0,0.0276976643747474,0,0,0,0.0570227096256954,0,0,0,0,0,0,0.0268754855385351,0.0272521220735421,0,0,0.0272572747044308,0,0,0.0279828799050574,0,0.0281020165236696,0,0.0548581164983045,0,108783646,"damage induced long noncoding RNA","non_coding"]
["DKFZP434A062",5.36762549487119E-3,0.0459495216130332,0.0201572757428513,0.0308871915005768,0.0209800707450297,0.0352833171484105,0.0200317844542281,0.0421078146077862,0.0161973108883023,0.0413576907119794,0.0504794146077665,0.0378019405654162,0.0102091285047035,0.0562911113903942,0.0149755850523987,0.0152679729672323,0.0567671144984716,0.0744971223728351,0.0198434958314799,0.046454602587659,0.0557286679028624,0.0714297621371956,0.0953825046226153,0.015732069449029,0.0638590626380164,0.0714029354665297,0.0415532208601255,0.00504618901980546,26102,"uncharacterized LOC26102","non_coding"]
["DLEC1",0.192569866742046,0.11193471239349,0.100439713038033,0.232567190295916,0.18120186514883,0.120555278927587,0.159703063679006,0.227299476161193,0.229569400625633,0.182034844325385,0.0804892563016918,0.294199730361171,0.0881747802034759,0.22778981604074,0.119392599232406,0.121723656951619,0.188572859512716,0.0758906788093371,0.145018441159229,0.0960188795911609,0.063951677518134,0.149147578855213,0.228834729637667,0.209039430541139,0.243951081130662,0.264298681507447,0.251912622149874,0.214563503172064,9940,"DLEC1 cilia and flagella associated protein","protein_coding",null,null,"GO:0002357,GO:0003674,GO:0005515,GO:0005737,GO:0005829,GO:0005929,GO:0007283,GO:0008285,GO:0015631,GO:0030154,GO:0043014,GO:0048487","defense response to tumor cell|molecular_function|protein binding|cytoplasm|cytosol|cilium|spermatogenesis|negative regulation of cell population proliferation|tubulin binding|cell differentiation|alpha-tubulin binding|beta-tubulin binding"]
["DLX4",0.99958557099652,0.981775147403019,0.601829956474745,1.09412366990253,1.0616879814746,1.21413862080951,0.740001246637119,1.32112631877657,5.91246894357793,6.68678094723917,5.69140445099691,5.20322913959185,4.6496593123296,5.28283757705124,3.98115154164446,4.40913951139817,3.55167317664616,3.44819884871255,2.65101426051418,3.56279277354881,3.96868734273437,4.01745215815096,2.18814616408737,3.35429787401256,4.58881803553736,3.5926691019086,2.80721651892381,4.20833858850253,1748,"distal-less homeobox 4","protein_coding",null,null,"GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001227,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0006355,GO:0009790,GO:0030154,GO:0043565,GO:1990837","negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|regulation of DNA-templated transcription|embryo development|cell differentiation|sequence-specific DNA binding|sequence-specific double-stranded DNA binding",{"$nulls":4},"Homeobox"]
["DMXL1",2.91477452301107,2.53872795735943,1.69472918129091,1.25994266881847,3.28191058516262,2.41335621748808,1.60653247406676,1.58552450646507,2.43558311362953,1.49430118639374,1.11995060067834,1.72042971797524,2.8812188357505,1.58874142324151,2.13577778217967,2.48371447219407,1.69552511039586,1.67939863999628,1.42478021278867,2.14743605637245,2.0310746574943,1.6781816089733,2.27893651793676,2.20301242908215,2.13540828102975,1.28781718963136,1.9366278108566,1.32261044492787,1657,"Dmx like 1","protein_coding","hsa04142","Lysosome","GO:0007035,GO:0043291","vacuolar acidification|RAVE complex"]
["DNAH6",0.0303518257398937,0.0180435137650053,0.0320573029213721,0.0236511985023065,0.044487789703676,0.0178136944525301,0.0389372215630004,0.0148814528473119,0.0248054806158505,0.0255786111767931,0.0428162060791336,0.0477132164269429,0.0396884360912619,0.0144683749678234,0.0564540563044966,0.0377713104637639,0.0109430407144005,0.0245730409560839,0.0350647558288854,0.0127692947014353,0.0268571463957688,0.00540947419502859,0.0224729504205852,0.0148264513765937,0.0150457524076058,0.00540744257433767,0.0532347640713138,0.0124837247573709,1768,"dynein axonemal heavy chain 6","protein_coding","hsa04814,hsa05014,hsa05016,hsa05022","Motor proteins|Amyotrophic lateral sclerosis|Huntington disease|Pathways of neurodegeneration - multiple diseases","GO:0005524,GO:0005874,GO:0005930,GO:0008569,GO:0016887,GO:0030286,GO:0045505,GO:0051959,GO:0060294,GO:0097729","ATP binding|microtubule|axoneme|minus-end-directed microtubule motor activity|ATP hydrolysis activity|dynein complex|dynein intermediate chain binding|dynein light intermediate chain binding|cilium movement involved in cell motility|9+2 motile cilium","WP4803","Ciliopathies"]
["DNAJC16",6.75468966451567,5.48575148832509,4.21511385376626,4.5029931769254,6.46070743357136,4.87471128727323,3.92211815789339,4.21423927021484,4.8261114535329,3.85518928548604,3.75597965567156,4.13050325613048,5.18310381900545,4.44224849704507,4.94402783551234,5.34553140120971,3.83124911137043,3.84003652202933,2.98103306427867,4.1240970358232,3.27626029246018,3.81752827598659,3.66936526898217,3.73166043094328,3.92858646210254,3.45952953097949,3.27684058193029,3.21289366290341,23341,"DnaJ heat shock protein family (Hsp40) member C16","protein_coding",null,null,"GO:0005789,GO:0016243","endoplasmic reticulum membrane|regulation of autophagosome size"]
["DNAJC27",1.01990777110408,1.06560372647233,0.803726420430166,0.699403242788791,1.39422256057712,1.06691842004798,0.744488475343031,0.912025051779387,1.00462701484149,1.03319838069444,0.665948267035234,0.7336966332006,1.08048444622461,0.891747271805048,1.11068873541731,1.09730062686241,0.980579541608341,0.933905623397611,0.761910881505981,1.18911397158906,1.04743397450975,1.03476033667512,1.08512791771409,1.04288724172716,1.0111602467759,0.964074607881916,1.09944763672082,0.730301569270156,51277,"DnaJ heat shock protein family (Hsp40) member C27","protein_coding",null,null,"GO:0003924,GO:0005515,GO:0005525,GO:0005634,GO:0006886,GO:0070374,GO:0071701","GTPase activity|protein binding|GTP binding|nucleus|intracellular protein transport|positive regulation of ERK1 and ERK2 cascade|regulation of MAPK export from nucleus"]
["DNHD1",0.381528835334649,0.648964853353445,0.55987813287963,0.619736679090183,0.471895093945052,0.555164894935518,0.492255081438382,0.505575657380385,0.625781066661178,0.827615248468125,0.534976233809546,0.568858351253902,0.578567617026454,0.765166951488077,0.573784982250549,0.699052197292064,0.404820413294546,0.459555815674394,0.295435937332145,0.439602406941731,0.447700154620548,0.463939866973227,0.341023619810752,0.397928579475223,0.419149146168085,0.418042254791682,0.415764016495757,0.420077139110002,144132,"dynein heavy chain domain 1","protein_coding",null,null,"GO:0005524,GO:0008569,GO:0030317,GO:0036126,GO:0036156,GO:0045505,GO:0051959,GO:0070062,GO:0120316","ATP binding|minus-end-directed microtubule motor activity|flagellated sperm motility|sperm flagellum|inner dynein arm|dynein intermediate chain binding|dynein light intermediate chain binding|extracellular exosome|sperm flagellum assembly"]
["DOCK9",1.49076265126746,1.39238814135382,1.10227548046036,0.971298279723835,1.5004994030453,1.17827431266308,1.12886087552086,0.902296312863975,1.56862061164839,1.30343760678639,0.904681964885133,1.23833749234563,1.49725247953991,1.25036673003056,1.19469418512885,1.36531517368112,1.4907239986386,1.12504112647268,0.80900566793882,1.37321926416832,1.48037257674117,1.36023026196533,1.07945129968233,1.4505968830837,1.59645179517359,0.905533381914623,0.731410140964289,0.870664744521062,23348,"dedicator of cytokinesis 9","protein_coding",null,null,"GO:0005085,GO:0005515,GO:0005829,GO:0007264,GO:0008150,GO:0012505,GO:0016020,GO:0043547,GO:0045296","guanyl-nucleotide exchange factor activity|protein binding|cytosol|small GTPase mediated signal transduction|biological_process|endomembrane system|membrane|positive regulation of GTPase activity|cadherin binding",null,null,"R-HSA-109582,R-HSA-162582,R-HSA-194315,R-HSA-9012999,R-HSA-9013148,R-HSA-9013149,R-HSA-9716542,R-HSA-983231","Hemostasis|Signal Transduction|Signaling by Rho GTPases|RHO GTPase cycle|CDC42 GTPase cycle|RAC1 GTPase cycle|Signaling by Rho GTPases, Miro GTPases and RHOBTB3|Factors involved in megakaryocyte development and platelet production"]
["DPH2",5.02192628884195,5.11123892100032,6.4667484904243,5.25672235572176,3.89522122461653,4.73419429706249,5.58785501969545,4.52209541596877,5.00223918062786,5.98478313123126,5.91732176089782,5.38668551466355,4.4598979355379,4.13575797761826,5.16102409805814,4.63185696758733,5.19462586257413,5.82182455648924,6.97108697378711,5.36472365613438,6.47363332848327,5.26573785822629,5.7390259803832,5.68899913648932,5.41474624941338,5.40301313605641,5.8239873821259,6.1540826540414,1802,"diphthamide biosynthesis 2","protein_coding",null,null,"GO:0005515,GO:0005829,GO:0017183,GO:0032991,GO:0046872,GO:0051539,GO:0090560","protein binding|cytosol|protein histidyl modification to diphthamide|protein-containing complex|metal ion binding|4 iron, 4 sulfur cluster binding|2-(3-amino-3-carboxypropyl)histidine synthase activity",null,null,"R-HSA-163841,R-HSA-392499,R-HSA-5358493,R-HSA-597592","Gamma carboxylation, hypusine formation and arylsulfatase activation|Metabolism of proteins|Synthesis of diphthamide-EEF2|Post-translational protein modification"]
["DPP3",19.0517611437056,19.3166261099193,20.1127705998296,21.255485300167,18.2303840256874,19.0515587044078,19.8173690531075,20.1130667575024,19.6323829964049,22.3900353572018,23.4732807689692,20.0444728942737,18.5999191102817,20.2890402920497,17.5578150491293,18.1600484782359,17.3525428465197,21.1535083093531,19.8465133856393,20.8640194399321,18.2115953819673,19.1400957963239,16.6673396630286,17.68239657301,17.8937054694178,19.6143595294469,17.6809462458961,21.5406670688435,10072,"dipeptidyl peptidase 3","protein_coding",null,null,"GO:0004177,GO:0005515,GO:0005737,GO:0005829,GO:0006508,GO:0008235,GO:0008239,GO:0008270,GO:0030163,GO:0070062","aminopeptidase activity|protein binding|cytoplasm|cytosol|proteolysis|metalloexopeptidase activity|dipeptidyl-peptidase activity|zinc ion binding|protein catabolic process|extracellular exosome",null,null,"R-HSA-2262752,R-HSA-392499,R-HSA-597592,R-HSA-8951664,R-HSA-8953897,R-HSA-9711123,R-HSA-9755511","Cellular responses to stress|Metabolism of proteins|Post-translational protein modification|Neddylation|Cellular responses to stimuli|Cellular response to chemical stress|KEAP1-NFE2L2 pathway"]
["DRG1",42.3042585043184,34.8486139429093,40.7503299956137,39.7337840197176,34.1872520906016,34.4807647237591,43.2306481706277,41.8644428198437,38.3508545319086,32.5893013933274,39.3583902771247,41.6657367515172,36.1201173875547,35.1920410591229,38.4845013149795,35.2140528516246,47.7709076721678,40.44589714123,50.6200606621978,39.7776951130328,42.1752367881279,43.5050274747156,51.497272036303,51.7693933785999,44.0762154010036,44.8116552377655,58.3584102829823,48.4921853250914,4733,"developmentally regulated GTP binding protein 1","protein_coding",null,null,"GO:0002181,GO:0003924,GO:0005515,GO:0005525,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005844,GO:0008017,GO:0016020,GO:0016604,GO:0030955,GO:0031116,GO:0042802,GO:1901673","cytoplasmic translation|GTPase activity|protein binding|GTP binding|nucleus|nucleoplasm|cytoplasm|cytosol|polysome|microtubule binding|membrane|nuclear body|potassium ion binding|positive regulation of microtubule polymerization|identical protein binding|regulation of mitotic spindle assembly"]
["DST-AS1",0.09778554498879,0.0620068514149275,0.0612030464211605,0.0625213525658592,0,0,0.15205505067886,0.319627335187881,0.0327863342527426,0.0627866755609312,0.367846607245761,0.0655869219276284,0.0929931862465921,0.155377575795624,0.121253346446024,0.123620733964434,0.282044634616018,0.120636694415599,0.0602503241025952,0.0626884358982195,0.0615300363214631,0.061965843056313,0.0321786200601084,0,0.161578099842864,0,0.346959345035528,0.275789179343612,101930010,"DST antisense RNA 1","non_coding"]
["DUSP14",17.6353161360437,16.8240592903917,13.8615858784798,16.2082242211794,15.6931099465604,15.8947547033005,15.0409499071968,15.3707228865219,13.0905720003169,14.6922961267427,13.3420731259639,13.8946958826439,11.4941892966246,11.3144336381898,10.3450855321676,10.7379257307818,14.7590945562533,14.2847554903344,11.6074303371971,13.9960176265027,15.653850547358,15.2406198123814,9.70290915611817,14.4674153779173,15.3061465089329,14.8606763311311,11.1030779518738,13.8969391441087,11072,"dual specificity phosphatase 14","protein_coding",null,null,"GO:0003723,GO:0004725,GO:0005515,GO:0016311,GO:0017017,GO:0017018","RNA binding|protein tyrosine phosphatase activity|protein binding|dephosphorylation|MAP kinase tyrosine/serine/threonine phosphatase activity|myosin phosphatase activity","WP5287,WP516","17q12 copy number variation syndrome|Hypertrophy model"]
["DUSP28",0.598906014113662,0.564480267329409,0.516270133146867,0.621380920022611,0.558624576073603,0.618643594801553,0.6654489204361,0.501862043684822,0.503840730213224,0.466702452162313,0.599078803448673,0.454650768333098,0.533309943962227,0.384116214241189,0.450646841974688,0.495581564881055,0.607219773513406,0.58437282209035,0.618937913354887,0.643984082811834,0.493333936945425,0.569282240237608,0.628877216399925,0.345749641839799,0.502004978267606,0.553548388271945,0.474177559189041,0.46066986733421,285193,"dual specificity phosphatase 28","protein_coding",null,null,"GO:0004725,GO:0008138,GO:0016311,GO:0016791,GO:0017018","protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity|dephosphorylation|phosphatase activity|myosin phosphatase activity","WP5224","2q37 copy number variation syndrome"]
["DYNC2I2",28.1391539180842,25.2038293163192,23.7804050783278,30.3622447895168,20.6909301540269,23.3415193376046,22.6942371661307,23.9972100527496,19.4247250387744,30.1777801644975,25.4898226963057,24.2341158099912,16.5510357717172,17.0013921832886,17.0932132838729,13.7396681361513,33.2667237164763,38.6095986844431,43.1852377903988,34.1403869740191,35.1703392472249,38.7646145333188,36.5381964512579,35.783321177323,35.7262030548777,42.9088725414166,39.3064122232093,43.4413762641645,89891,"dynein 2 intermediate chain 2","protein_coding",null,null,"GO:0005515,GO:0005737,GO:0005813,GO:0005814,GO:0005829,GO:0005868,GO:0005929,GO:0005930,GO:0030175,GO:0035721,GO:0036064,GO:0042073,GO:0045503,GO:0045504,GO:0060271,GO:0097014,GO:0097542","protein binding|cytoplasm|centrosome|centriole|cytosol|cytoplasmic dynein complex|cilium|axoneme|filopodium|intraciliary retrograde transport|ciliary basal body|intraciliary transport|dynein light chain binding|dynein heavy chain binding|cilium assembly|ciliary plasm|ciliary tip","WP4532,WP4352,WP4536,WP4803,WP5234,WP4906","Intraflagellar transport proteins binding to dynein|Ciliary landscape|Genes related to primary cilium development (based on CRISPR)|Ciliopathies|Bardet-Biedl syndrome|3q29 copy number variation syndrome","R-HSA-1852241,R-HSA-5617833,R-HSA-5620924","Organelle biogenesis and maintenance|Cilium Assembly|Intraflagellar transport"]
["E2F3-IT1",0,0,0,0,0,0,0,0,0,0,0,0,0.0640878041882764,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,100874268,"E2F3 intronic transcript 1","non_coding"]
["ECE1-AS1",0.0733075006397443,0.00996108510492328,0.0294958737705709,0.0401749483853656,0.0204665725100115,0.0393368450925336,0.00977074801176513,0.0102693009401856,0,0.0100863598851768,0.0196975617840096,0.0105362052125386,0.0199185094602257,0.00998424671196439,0,0.00992952088078745,0,0,0.00967890793178832,0.0402823127333547,0.00988448718683955,0.0199089946416359,0.0206773261769306,0.0204626917309048,0,0.00995075873884206,0,0,100506801,"ECE1 antisense RNA 1","non_coding"]
["ECI2-DT",0.10654630527764,0.135124284901568,0.0666863233073778,0.0908303180886527,0.21979319173795,0.155637082757415,0.0773163538322284,0.0928701998068962,0.0238158088950533,0.136823664529354,0.0445336179464565,0.03573147854687,0.0788080156904585,0.135438477136212,0.165145779826847,0.15714546089594,0.0682918790301412,0.0657223625044142,0.0328241225512821,0.136609582313116,0.0893901449940273,0.0112529100148377,0.0701231061652428,0.115658692392071,0.105632481083042,0.089989470333876,0.114558780829792,0.0556476970958784,100507506,"ECI2 divergent transcript","non_coding",{"$nulls":4},"WP5097","CCL18 signaling pathway"]
["EEF1A2",0.471315664011583,0.578450830458489,0.21410710401988,0.554087993721007,0.653683625548185,0.58536021009524,0.0709247190701733,0.134178581827603,0.137636032624457,0.219647126433545,0.100087610892353,0.244739467271962,0.245796428922887,0.202928547384291,0.113115078974463,0.144154465578944,0.160792131422066,0.365754399791909,0.168619350364962,0.160822532816159,0.15785074461826,0.346840962487789,0.0900565779685606,0.222804435344116,0.256246644747979,0.491173492266498,0.102986599416021,0.25727879449201,1917,"eukaryotic translation elongation factor 1 alpha 2","protein_coding","hsa03013,hsa05134,hsa05140","Nucleocytoplasmic transport|Legionellosis|Leishmaniasis","GO:0003746,GO:0003924,GO:0005515,GO:0005525,GO:0005634,GO:0005737,GO:0005853,GO:0006412,GO:0006414,GO:0008135,GO:0019901,GO:0043065,GO:0045202,GO:0090218,GO:0098574,GO:1904714","translation elongation factor activity|GTPase activity|protein binding|GTP binding|nucleus|cytoplasm|eukaryotic translation elongation factor 1 complex|translation|translational elongation|translation factor activity, RNA binding|protein kinase binding|positive regulation of apoptotic process|synapse|positive regulation of lipid kinase activity|cytoplasmic side of lysosomal membrane|regulation of chaperone-mediated autophagy","WP107","Translation factors","R-HSA-156842,R-HSA-392499,R-HSA-72766","Eukaryotic Translation Elongation|Metabolism of proteins|Translation"]
["EFCAB14",18.0078824830934,17.2034155807913,16.1885950705952,15.1773350974095,19.050093587306,16.9016161473962,16.7882211792,15.6363373755458,18.3372270950472,14.7061624007128,14.6604716214358,16.7467303496185,18.7647151613327,16.2935491529942,18.2771493365809,18.0012944650268,14.5378054467931,13.7935782786759,13.2298142258434,15.4050553754873,14.7223701708271,13.6813912976375,15.7602494809265,15.737002454818,16.1581377514479,12.9056978725747,14.5021490859976,13.0783166056221,9813,"EF-hand calcium binding domain 14","protein_coding",null,null,"GO:0005509","calcium ion binding"]
["EGFR",17.4612676267847,16.112684099447,13.1154963082766,11.5858106697749,18.1734781674905,14.7555459561861,12.5936605055942,12.4381913182763,12.3671762843807,9.94914408141463,7.54954433714161,9.75206701846141,11.7104520123498,8.25836914381568,10.30012798008,10.1299413124904,10.0382966285919,9.89414882066486,8.0276135642312,11.4965445576402,10.3801284351298,9.7204137490076,10.2096591558665,10.9494955551073,10.3373219826659,8.25308458240097,8.36172932429151,8.03038782823783,1956,"epidermal growth factor receptor","protein_coding","hsa04010,hsa04012,hsa04014,hsa04015,hsa04630,hsa04066,hsa04068,hsa04020,hsa04072,hsa04151,hsa04144,hsa04510,hsa04520,hsa04540,hsa04810,hsa04912,hsa04915,hsa04921,hsa04926,hsa04928,hsa05200,hsa05206,hsa05205,hsa05207,hsa05208,hsa05230,hsa05231,hsa05235,hsa05210,hsa05212,hsa05225,hsa05226,hsa05214,hsa05218,hsa05219,hsa05215,hsa05213,hsa05224,hsa05223,hsa05160,hsa05171,hsa05163,hsa05165,hsa05120,hsa05131,hsa04934,hsa01521,hsa01522","MAPK signaling pathway|ErbB signaling pathway|Ras signaling pathway|Rap1 signaling pathway|JAK-STAT signaling pathway|HIF-1 signaling pathway|FoxO signaling pathway|Calcium signaling pathway|Phospholipase D signaling pathway|PI3K-Akt signaling pathway|Endocytosis|Focal adhesion|Adherens junction|Gap junction|Regulation of actin cytoskeleton|GnRH signaling pathway|Estrogen signaling pathway|Oxytocin signaling pathway|Relaxin signaling pathway|Parathyroid hormone synthesis, secretion and action|Pathways in cancer|MicroRNAs in cancer|Proteoglycans in cancer|Chemical carcinogenesis - receptor activation|Chemical carcinogenesis - reactive oxygen species|Central carbon metabolism in cancer|Choline metabolism in cancer|PD-L1 expression and PD-1 checkpoint pathway in cancer|Colorectal cancer|Pancreatic cancer|Hepatocellular carcinoma|Gastric cancer|Glioma|Melanoma|Bladder cancer|Prostate cancer|Endometrial cancer|Breast cancer|Non-small cell lung cancer|Hepatitis C|Coronavirus disease - COVID-19|Human cytomegalovirus infection|Human papillomavirus infection|Epithelial cell signaling in Helicobacter pylori infection|Shigellosis|Cushing syndrome|EGFR tyrosine kinase inhibitor resistance|Endocrine resistance","GO:0000139,GO:0000165,GO:0000902,GO:0001503,GO:0001618,GO:0001892,GO:0001934,GO:0001942,GO:0003682,GO:0003690,GO:0004709,GO:0004713,GO:0004714,GO:0004888,GO:0005006,GO:0005515,GO:0005524,GO:0005615,GO:0005634,GO:0005737,GO:0005768,GO:0005789,GO:0005886,GO:0005925,GO:0007165,GO:0007166,GO:0007169,GO:0007173,GO:0007202,GO:0007275,GO:0007435,GO:0007611,GO:0008284,GO:0009925,GO:0009986,GO:0010008,GO:0010750,GO:0016020,GO:0016323,GO:0018108,GO:0019899,GO:0019900,GO:0019903,GO:0021795,GO:0022008,GO:0030054,GO:0030235,GO:0030296,GO:0030297,GO:0030307,GO:0030335,GO:0030669,GO:0031625,GO:0031901,GO:0031965,GO:0032587,GO:0032991,GO:0033138,GO:0033674,GO:0034614,GO:0038083,GO:0038134,GO:0042059,GO:0042177,GO:0042327,GO:0042802,GO:0043066,GO:0043235,GO:0043406,GO:0045121,GO:0045296,GO:0045737,GO:0045739,GO:0045740,GO:0045893,GO:0045944,GO:0046328,GO:0046718,GO:0046777,GO:0048146,GO:0048408,GO:0048471,GO:0048546,GO:0050673,GO:0050679,GO:0050730,GO:0050999,GO:0051015,GO:0051117,GO:0051205,GO:0051896,GO:0051897,GO:0060571,GO:0061029,GO:0070141,GO:0070372,GO:0070374,GO:0070435,GO:0071230,GO:0071276,GO:0071364,GO:0071392,GO:0090263,GO:0097489,GO:0097708,GO:0098609,GO:1900020,GO:1900087,GO:1901224,GO:1902895,GO:1903078,GO:1905208","Golgi membrane|MAPK cascade|cell morphogenesis|ossification|virus receptor activity|embryonic placenta development|positive regulation of protein phosphorylation|hair follicle development|chromatin binding|double-stranded DNA binding|MAP kinase kinase kinase activity|protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity|transmembrane signaling receptor activity|epidermal growth factor receptor activity|protein binding|ATP binding|extracellular space|nucleus|cytoplasm|endosome|endoplasmic reticulum membrane|plasma membrane|focal adhesion|signal transduction|cell surface receptor signaling pathway|transmembrane receptor protein tyrosine kinase signaling pathway|epidermal growth factor receptor signaling pathway|activation of phospholipase C activity|multicellular organism development|salivary gland morphogenesis|learning or memory|positive regulation of cell population proliferation|basal plasma membrane|cell surface|endosome membrane|positive regulation of nitric oxide mediated signal transduction|membrane|basolateral plasma membrane|peptidyl-tyrosine phosphorylation|enzyme binding|kinase binding|protein phosphatase binding|cerebral cortex cell migration|neurogenesis|cell junction|nitric-oxide synthase regulator activity|protein tyrosine kinase activator activity|transmembrane receptor protein tyrosine kinase activator activity|positive regulation of cell growth|positive regulation of cell migration|clathrin-coated endocytic vesicle membrane|ubiquitin protein ligase binding|early endosome membrane|nuclear membrane|ruffle membrane|protein-containing complex|positive regulation of peptidyl-serine phosphorylation|positive regulation of kinase activity|cellular response to reactive oxygen species|peptidyl-tyrosine autophosphorylation|ERBB2-EGFR signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of protein catabolic process|positive regulation of phosphorylation|identical protein binding|negative regulation of apoptotic process|receptor complex|positive regulation of MAP kinase activity|membrane raft|cadherin binding|positive regulation of cyclin-dependent protein serine/threonine kinase activity|positive regulation of DNA repair|positive regulation of DNA replication|positive regulation of DNA-templated transcription|positive regulation of transcription by RNA polymerase II|regulation of JNK cascade|viral entry into host cell|protein autophosphorylation|positive regulation of fibroblast proliferation|epidermal growth factor binding|perinuclear region of cytoplasm|digestive tract morphogenesis|epithelial cell proliferation|positive regulation of epithelial cell proliferation|regulation of peptidyl-tyrosine phosphorylation|regulation of nitric-oxide synthase activity|actin filament binding|ATPase binding|protein insertion into membrane|regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction|positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction|morphogenesis of an epithelial fold|eyelid development in camera-type eye|response to UV-A|regulation of ERK1 and ERK2 cascade|positive regulation of ERK1 and ERK2 cascade|Shc-EGFR complex|cellular response to amino acid stimulus|cellular response to cadmium ion|cellular response to epidermal growth factor stimulus|cellular response to estradiol stimulus|positive regulation of canonical Wnt signaling pathway|multivesicular body, internal vesicle lumen|intracellular vesicle|cell-cell adhesion|positive regulation of protein kinase C activity|positive regulation of G1/S transition of mitotic cell cycle|positive regulation of non-canonical NF-kappaB signal transduction|positive regulation of miRNA transcription|positive regulation of protein localization to plasma membrane|negative regulation of cardiocyte differentiation","WP306,WP3853,WP3927,WP2840,WP5224,WP4262,WP2363,WP4806,WP5413,WP4223,WP2828,WP673,WP4540,WP2261,WP2870,WP4018,WP4483,WP2643,WP4300,WP2586,WP51,WP2868,WP2817,WP2882,WP3932,WP4538,WP138,WP5366,WP4657,WP382,WP5158,WP5300,WP5322,WP2873,WP3303,WP437,WP4659,WP5144,WP2431,WP3680,WP4263,WP4674,WP4541,WP3611,WP4255,WP2324,WP4155,WP5362,WP5087,WP4172,WP4217,WP3931","Focal adhesion|ERK pathway in Huntington's disease|BMP signaling in eyelid development|Hair follicle development: cytodifferentiation - part 3 of 3|2q37 copy number variation syndrome|Breast cancer pathway|Gastric cancer network 2|EGFR tyrosine kinase inhibitor resistance|IL-24 Signaling pathway|Ras signaling|Bladder cancer|ErbB signaling pathway|Hippo signaling regulation pathways|Glioblastoma signaling pathways|Extracellular vesicle-mediated signaling in recipient cells|Clear cell renal cell carcinoma pathways|Relationship between inflammation, COX-2 and EGFR|Nanoparticle-mediated activation of receptor signaling|Extracellular vesicles in the crosstalk of cardiac cells|Aryl hydrocarbon receptor pathway|Regulation of actin cytoskeleton|TCA cycle nutrient use and invasiveness of ovarian cancer|Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4)|Nuclear receptors meta-pathway|Focal adhesion: PI3K-Akt-mTOR-signaling pathway|Regulatory circuits of the STAT3 signaling pathway|Androgen receptor signaling pathway|NF1 copy number variation syndrome |22q11.2 copy number variation syndrome|MAPK signaling pathway|Urotensin-II-mediated signaling pathway|TROP2 regulatory signaling|CKAP4 signaling pathway map|Aryl hydrocarbon receptor pathway|RAC1/PAK1/p38/MMP2 pathway|EGF/EGFR signaling pathway|Gastrin signaling pathway|NRP1-triggered signaling pathways in pancreatic cancer |Spinal cord injury|Physico-chemical features and toxicity-associated pathways|Pancreatic adenocarcinoma pathway|Head and neck squamous cell carcinoma|Hippo-Merlin signaling dysregulation|Photodynamic therapy-induced AP-1 survival signaling|Non-small cell lung cancer|AGE/RAGE pathway|Endometrial cancer|TAR syndrome|Pleural mesothelioma|PI3K-Akt signaling pathway|Ebola virus infection in host|Embryonic stem cell pluripotency pathways","R-HSA-1227986,R-HSA-1227986,R-HSA-1227990,R-HSA-1236382,R-HSA-1236394,R-HSA-1250196,R-HSA-1250196,R-HSA-1251932,R-HSA-1257604,R-HSA-1266738,R-HSA-157118,R-HSA-162582,R-HSA-162582,R-HSA-1643685,R-HSA-1643713,R-HSA-177929,R-HSA-179812,R-HSA-180292,R-HSA-180336,R-HSA-182971,R-HSA-1963640,R-HSA-1963642,R-HSA-199418,R-HSA-199991,R-HSA-212436,R-HSA-212718,R-HSA-2179392,R-HSA-2219528,R-HSA-2219530,R-HSA-372790,R-HSA-373760,R-HSA-388396,R-HSA-416476,R-HSA-422475,R-HSA-445144,R-HSA-5637810,R-HSA-5637812,R-HSA-5637815,R-HSA-5638302,R-HSA-5638303,R-HSA-5653656,R-HSA-5663202,R-HSA-5663205,R-HSA-5673001,R-HSA-5683057,R-HSA-5684996,R-HSA-6785631,R-HSA-6811558,R-HSA-73857,R-HSA-74160,R-HSA-881907,R-HSA-8847993,R-HSA-8848021,R-HSA-8856825,R-HSA-8856828,R-HSA-8857538,R-HSA-8863795,R-HSA-8864260,R-HSA-8866910,R-HSA-8939211,R-HSA-9006925,R-HSA-9006927,R-HSA-9006931,R-HSA-9006934,R-HSA-9006934,R-HSA-9009391,R-HSA-9012852,R-HSA-9013507,R-HSA-9609646,R-HSA-9609690,R-HSA-9634638,R-HSA-9664565,R-HSA-9665348,R-HSA-9665686,R-HSA-9675108,R-HSA-9824446","Signaling by ERBB2|Signaling by ERBB2|Signaling by ERBB2 in Cancer|Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants|Signaling by ERBB4|SHC1 events in ERBB2 signaling|SHC1 events in ERBB2 signaling|PLCG1 events in ERBB2 signaling|PIP3 activates AKT signaling|Developmental Biology|Signaling by NOTCH|Signal Transduction|Signal Transduction|Disease|Signaling by EGFR in Cancer|Signaling by EGFR|GRB2 events in EGFR signaling|GAB1 signalosome|SHC1 events in EGFR signaling|EGFR downregulation|GRB2 events in ERBB2 signaling|PI3K events in ERBB2 signaling|Negative regulation of the PI3K/AKT network|Membrane Trafficking|Generic Transcription Pathway|EGFR interacts with phospholipase C-gamma|EGFR Transactivation by Gastrin|PI3K/AKT Signaling in Cancer|Constitutive Signaling by Aberrant PI3K in Cancer|Signaling by GPCR|L1CAM interactions|GPCR downstream signalling|G alpha (q) signalling events|Axon guidance|Signal transduction by L1|Constitutive Signaling by EGFRvIII|Signaling by EGFRvIII in Cancer|Signaling by Ligand-Responsive EGFR Variants in Cancer|Signaling by Overexpressed Wild-Type EGFR in Cancer|Inhibition of Signaling by Overexpressed EGFR|Vesicle-mediated transport|Diseases of signal transduction by growth factor receptors and second messengers|Infectious disease|RAF/MAP kinase cascade|MAPK family signaling cascades|MAPK1/MAPK3 signaling|ERBB2 Regulates Cell Motility|PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling|RNA Polymerase II Transcription|Gene expression (Transcription)|Gastrin-CREB signalling pathway via PKC and MAPK|ERBB2 Activates PTK6 Signaling|Signaling by PTK6|Cargo recognition for clathrin-mediated endocytosis|Clathrin-mediated endocytosis|PTK6 promotes HIF1A stabilization|Downregulation of ERBB2 signaling|Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors|TFAP2 (AP-2) family regulates transcription of growth factors and their receptors|ESR-mediated signaling|Intracellular signaling by second messengers|Signaling by Non-Receptor Tyrosine Kinases|Signaling by Nuclear Receptors|Signaling by Receptor Tyrosine Kinases|Signaling by Receptor Tyrosine Kinases|Extra-nuclear estrogen signaling|Signaling by NOTCH3|NOTCH3 Activation and Transmission of Signal to the Nucleus|HCMV Infection|HCMV Early Events|Estrogen-dependent nuclear events downstream of ESR-membrane signaling|Signaling by ERBB2 KD Mutants|Signaling by ERBB2 ECD mutants|Signaling by ERBB2 TMD/JMD mutants|Nervous system development|Viral Infection Pathways"]
["EHBP1",12.5241735555197,13.0692256621854,13.0337267619021,10.7801732913636,13.318337088439,11.9182288250912,13.0523983085987,10.8719087905407,12.687296406451,9.30781939852443,10.7855603444267,11.5168431031629,13.0634328209149,11.2602965780139,14.6289098670595,13.2509725442609,12.3463794019143,13.1026906761686,13.6811715739082,15.4316056485794,12.6590662708264,13.4537895562805,16.4056898478697,14.3610088781763,13.325385866398,11.6867455451177,14.7455155403618,11.3416926754858,23301,"EH domain binding protein 1","protein_coding",null,null,"GO:0005654,GO:0005768,GO:0005829,GO:0005886,GO:0006897,GO:0015031","nucleoplasm|endosome|cytosol|plasma membrane|endocytosis|protein transport","WP5323,WP4352","Fatty Acids and Lipoproteins Transport in Hepatocytes|Ciliary landscape"]
["EIF2AK1",31.2974128898596,32.1357008392348,30.3131504908831,31.2287533614508,29.9277035624606,30.9822042983378,31.9293978188825,32.7872006912617,29.4998408956296,30.0480117821355,32.2227584639428,32.3085558383693,28.8104188478036,30.3215745261009,29.6483369704888,28.5697042951787,32.3595444226193,32.6139125841984,29.1573147027485,32.9932517553316,29.3201197299803,31.0565210363002,27.3192936732233,30.4002347462132,32.0226487654035,31.8919881634608,28.1431921022837,30.2613475975412,27102,"eukaryotic translation initiation factor 2 alpha kinase 1","protein_coding","hsa05160,hsa05162,hsa05168","Hepatitis C|Measles|Herpes simplex virus 1 infection","GO:0002526,GO:0004694,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0006468,GO:0006909,GO:0008285,GO:0010999,GO:0020037,GO:0030225,GO:0042803,GO:0045993,GO:0046501,GO:0046777,GO:0046986,GO:0051649,GO:0060586,GO:0106310,GO:0140467,GO:0140468,GO:1990641","acute inflammatory response|eukaryotic translation initiation factor 2alpha kinase activity|protein binding|ATP binding|nucleus|cytoplasm|protein phosphorylation|phagocytosis|negative regulation of cell population proliferation|regulation of eIF2 alpha phosphorylation by heme|heme binding|macrophage differentiation|protein homodimerization activity|negative regulation of translational initiation by iron|protoporphyrinogen IX metabolic process|protein autophosphorylation|negative regulation of hemoglobin biosynthetic process|establishment of localization in cell|multicellular organismal-level iron ion homeostasis|protein serine kinase activity|integrated stress response signaling|HRI-mediated signaling|response to iron ion starvation","WP4630,WP4861,WP107,WP5044","Measles virus infection|Endoplasmic reticulum stress response in coronavirus infection|Translation factors|Kynurenine pathway and links to cell senescence","R-HSA-2262752,R-HSA-8953897,R-HSA-9648895","Cellular responses to stress|Cellular responses to stimuli|Response of EIF2AK1 (HRI) to heme deficiency"]
["EIF4A3",33.4816698742025,32.4256525862724,35.0935455360636,32.889315407009,27.1649232842558,30.2074241556817,31.5968106050795,33.7326762191528,33.0871787461236,36.8347708888501,38.3575911803414,35.5979385163103,31.7188926275732,32.0123114338585,33.8592163425642,31.1887667120493,32.6423953107261,35.1791704400609,36.2153980115913,34.1377279091796,30.9263516711814,33.0945230183599,31.0716066851324,29.7891472090574,32.188610875828,33.8228891554148,30.7977030494978,36.7177307125762,9775,"eukaryotic translation initiation factor 4A3","protein_coding","hsa03040,hsa03013,hsa03015","Spliceosome|Nucleocytoplasmic transport|mRNA surveillance pathway","GO:0000184,GO:0000398,GO:0003723,GO:0003724,GO:0003729,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0006364,GO:0006406,GO:0008143,GO:0008306,GO:0014070,GO:0016020,GO:0016607,GO:0016887,GO:0017148,GO:0030425,GO:0035145,GO:0035368,GO:0035613,GO:0035640,GO:0043021,GO:0043025,GO:0045727,GO:0048701,GO:0071006,GO:0071013,GO:0072715,GO:0090394,GO:0098794,GO:0098978,GO:0099578,GO:1904570,GO:1990416,GO:2000622","nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|mRNA splicing, via spliceosome|RNA binding|RNA helicase activity|mRNA binding|protein binding|ATP binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|rRNA processing|mRNA export from nucleus|poly(A) binding|associative learning|response to organic cyclic compound|membrane|nuclear speck|ATP hydrolysis activity|negative regulation of translation|dendrite|exon-exon junction complex|selenocysteine insertion sequence binding|RNA stem-loop binding|exploration behavior|ribonucleoprotein complex binding|neuronal cell body|positive regulation of translation|embryonic cranial skeleton morphogenesis|U2-type catalytic step 1 spliceosome|catalytic step 2 spliceosome|cellular response to selenite ion|negative regulation of excitatory postsynaptic potential|postsynapse|glutamatergic synapse|regulation of translation at postsynapse, modulating synaptic transmission|negative regulation of selenocysteine incorporation|cellular response to brain-derived neurotrophic factor stimulus|regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay","WP5362","TAR syndrome","R-HSA-1169408,R-HSA-1169410,R-HSA-1266738,R-HSA-1280215,R-HSA-159236,R-HSA-168256,R-HSA-376176,R-HSA-422475,R-HSA-429914,R-HSA-429947,R-HSA-72163,R-HSA-72172,R-HSA-72187,R-HSA-72202,R-HSA-72203,R-HSA-73856,R-HSA-73857,R-HSA-74160,R-HSA-8953854,R-HSA-9010553,R-HSA-913531,R-HSA-927802,R-HSA-9675108,R-HSA-975957","ISG15 antiviral mechanism|Antiviral mechanism by IFN-stimulated genes|Developmental Biology|Cytokine Signaling in Immune system|Transport of Mature mRNA derived from an Intron-Containing Transcript|Immune System|Signaling by ROBO receptors|Axon guidance|Deadenylation-dependent mRNA decay|Deadenylation of mRNA|mRNA Splicing - Major Pathway|mRNA Splicing|mRNA 3'-end processing|Transport of Mature Transcript to Cytoplasm|Processing of Capped Intron-Containing Pre-mRNA|RNA Polymerase II Transcription Termination|RNA Polymerase II Transcription|Gene expression (Transcription)|Metabolism of RNA|Regulation of expression of SLITs and ROBOs|Interferon Signaling|Nonsense-Mediated Decay (NMD)|Nervous system development|Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"]
["ELAPOR2",0.105435000920116,0.109403104203225,0.125982376104811,0.0827331564207105,0.128002800952445,0.117010445995587,0.0834653728462649,0.112788254393903,0.250671480064883,0.147705337979538,0.201315758572166,0.189651693825694,0.276495919456354,0.201038730403622,0.306047211793848,0.26658239110453,0.190451537477799,0.171460817954801,0.298241603728663,0.285731319981507,0.277435775956039,0.224735431039483,0.258641808789403,0.230985638860723,0.196391027411237,0.182149481999142,0.287532084713734,0.225275227487226,222223,"endosome-lysosome associated apoptosis and autophagy regulator family member 2","protein_coding",null,null,"GO:0005886,GO:0030513,GO:0045684,GO:0051961,GO:0070700","plasma membrane|positive regulation of BMP signaling pathway|positive regulation of epidermis development|negative regulation of nervous system development|BMP receptor binding"]
["ELF4",6.42027698963881,8.07707936066683,6.79626054551908,6.63370748151525,6.3741772813479,6.83142912240925,6.57863085186369,6.28692910016833,6.59743759236658,8.61387857237273,6.06735250242346,6.47283591836563,5.88863209935764,6.00151495576615,6.44099788824956,6.2104184228752,5.44574745301149,5.61756030308166,5.39620402762359,6.20399097223629,6.05556660699393,6.59177725491576,4.76139964403436,4.94801131613072,5.13652622619476,4.93134829423803,4.41605561540957,5.91382531584946,2000,"E74 like ETS transcription factor 4","protein_coding",null,null,"GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0001787,GO:0001866,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0016604,GO:0016605,GO:0030154,GO:0032691,GO:0032715,GO:0032720,GO:0045893,GO:0045944,GO:0050728,GO:1990837","chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|natural killer cell proliferation|NK T cell proliferation|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|nuclear body|PML body|cell differentiation|negative regulation of interleukin-1 beta production|negative regulation of interleukin-6 production|negative regulation of tumor necrosis factor production|positive regulation of DNA-templated transcription|positive regulation of transcription by RNA polymerase II|negative regulation of inflammatory response|sequence-specific double-stranded DNA binding","WP3945","TYROBP causal network in microglia"]
["ELP2",12.8422446524689,12.0040901506471,12.8869445277377,11.7380958691543,13.1992453854785,12.217968456958,12.5122747074024,12.8596335994318,11.9243825469,8.87177836274766,11.1076713133832,11.7855106783136,12.4892102006874,11.9158228986189,13.4426559060289,12.564502885667,11.7281862328652,10.6132778312311,11.5485246964965,12.1120023984254,10.8146830832732,11.0279052942338,12.0056577639446,11.6673491170548,11.7655752031771,10.7298361330148,11.5836057455696,11.0156896621637,55250,"elongator acetyltransferase complex subunit 2","protein_coding",null,null,"GO:0000993,GO:0002098,GO:0005654,GO:0005737,GO:0005829,GO:0006357,GO:0006368,GO:0006417,GO:0008023,GO:0019901,GO:0033588,GO:0046425","RNA polymerase II complex binding|tRNA wobble uridine modification|nucleoplasm|cytoplasm|cytosol|regulation of transcription by RNA polymerase II|transcription elongation by RNA polymerase II|regulation of translation|transcription elongation factor complex|protein kinase binding|elongator holoenzyme complex|regulation of receptor signaling pathway via JAK-STAT",null,null,"R-HSA-3214847,R-HSA-3247509,R-HSA-4839726","HATs acetylate histones|Chromatin modifying enzymes|Chromatin organization"]
["EMILIN2",1.72153678543589,1.97739698781804,2.31183746608887,1.98962453356957,1.83127015242772,1.95630366896486,2.19172174632995,2.08131915310564,1.81492636197017,1.69583917528792,2.62729805210493,1.95563552608167,1.64545566776043,1.95706409672382,2.07524563320781,1.78930768981642,1.73476830882175,2.43569094398331,2.3040464280346,1.63031995907557,1.99510023592217,1.8062366986662,1.94908789195448,1.65208858398993,1.88825104947814,1.89252330123802,1.62794232440554,1.98720310588028,84034,"elastin microfibril interfacer 2","protein_coding",null,null,"GO:0005515,GO:0005576,GO:0005581,GO:0008217,GO:0030023,GO:0030194,GO:0030336,GO:0033627,GO:0042127,GO:0043065,GO:0045766,GO:0062023,GO:1900426,GO:1901731,GO:1990971","protein binding|extracellular region|collagen trimer|regulation of blood pressure|extracellular matrix constituent conferring elasticity|positive regulation of blood coagulation|negative regulation of cell migration|cell adhesion mediated by integrin|regulation of cell population proliferation|positive regulation of apoptotic process|positive regulation of angiogenesis|collagen-containing extracellular matrix|positive regulation of defense response to bacterium|positive regulation of platelet aggregation|EMILIN complex",null,null,"R-HSA-1474244,R-HSA-1474244,R-HSA-1566948,R-HSA-1566948,R-HSA-2129379,R-HSA-2129379","Extracellular matrix organization|Extracellular matrix organization|Elastic fibre formation|Elastic fibre formation|Molecules associated with elastic fibres|Molecules associated with elastic fibres"]
["ENO2",26.3334256068787,29.3393904894029,29.5547883711013,32.2537410272374,26.4208551724958,27.1449952702404,27.5837671934721,30.7081195956411,28.118969467252,32.1869022404541,31.9591995424284,32.0855281940452,25.2998759690074,32.7236689092841,29.6917282124032,28.0208568740516,31.1136788688748,35.444522763551,27.9543906749229,30.7127699594409,29.0472331209959,33.6090820384875,24.5236153101335,26.55360727463,32.3053505322359,32.5134231551376,24.9820490696127,31.2300455426538,2026,"enolase 2","protein_coding","hsa00010,hsa03018,hsa04066","Glycolysis / Gluconeogenesis|RNA degradation|HIF-1 signaling pathway","GO:0000015,GO:0000287,GO:0001917,GO:0004634,GO:0005515,GO:0005615,GO:0005829,GO:0005886,GO:0006094,GO:0006096,GO:0016020,GO:0043204,GO:0061621,GO:0070062","phosphopyruvate hydratase complex|magnesium ion binding|photoreceptor inner segment|phosphopyruvate hydratase activity|protein binding|extracellular space|cytosol|plasma membrane|gluconeogenesis|glycolytic process|membrane|perikaryon|canonical glycolysis|extracellular exosome","WP4018,WP534,WP5355","Clear cell renal cell carcinoma pathways|Glycolysis and gluconeogenesis|Metabolic Epileptic Disorders","R-HSA-1430728,R-HSA-70171,R-HSA-70263,R-HSA-70326,R-HSA-71387","Metabolism|Glycolysis|Gluconeogenesis|Glucose metabolism|Metabolism of carbohydrates"]
["ENTR1",14.4035319611406,15.7359926720813,15.7261544710942,17.4730512857313,13.6299600800533,14.4383649205778,14.4898956210931,16.5067963365637,11.7734506403469,14.9579440342756,16.0447860860888,13.0555585855114,10.580510518847,13.4756998722774,12.0681846448151,12.4116497207088,13.7984173807482,14.6760531258274,15.5864722691929,13.8507417966136,12.1992088698336,14.782050502529,13.9642621036911,12.8697379916676,12.8243180514868,14.6782508525916,13.9280275710632,15.4365302941508,10807,"endosome associated trafficking regulator 1","protein_coding",null,null,"GO:0005515,GO:0005768,GO:0005769,GO:0005813,GO:0007049,GO:0015031,GO:0030030,GO:0030496,GO:0032456,GO:0032465,GO:0036064,GO:0045724,GO:0051301,GO:0055037,GO:1903566","protein binding|endosome|early endosome|centrosome|cell cycle|protein transport|cell projection organization|midbody|endocytic recycling|regulation of cytokinesis|ciliary basal body|positive regulation of cilium assembly|cell division|recycling endosome|positive regulation of protein localization to cilium"]
["EP300-AS1",0.391236795867098,0.316311438331809,0.146922842932655,0.393979800439505,0.248495083211177,0.312282595711009,0.529279576259956,0.249369628490922,0.31482494545159,0.39565173964684,0.533506602659354,0.472340067641353,0.223237634327813,0.279747289948436,0.291078425285521,0.204023551682595,0.413765528318323,0.361997628017782,0.397748329725187,0.150488640022721,0.516977329847533,0.334696494824483,0.135182896609555,0.324893492293518,0.446063430640222,0.315983527499456,0.283944496316514,0.220684713417675,101927279,"EP300 antisense RNA 1","non_coding"]
["EPHB2",5.01131847786402,5.84756294349274,5.16175464200313,5.48820641867388,4.84605706407115,5.54011830687722,4.80777838888248,5.23844520833601,7.49095176106244,9.46420944364511,9.08352310645028,8.07972068944129,6.79019525837396,7.50552816670514,6.94130771357729,7.07459172122797,6.72622932073189,8.64179940072669,6.75846352930402,7.7294693107016,6.78381998400998,7.40006808326523,5.53273704699722,6.0408416427675,7.45367747970719,7.24911858330387,4.76705203904442,7.303389307962,2048,"EPH receptor B2","protein_coding","hsa04360","Axon guidance","GO:0001525,GO:0001540,GO:0001655,GO:0001933,GO:0002639,GO:0004713,GO:0005005,GO:0005102,GO:0005515,GO:0005524,GO:0005576,GO:0005654,GO:0005829,GO:0005886,GO:0006468,GO:0006469,GO:0007162,GO:0007399,GO:0007411,GO:0007413,GO:0007611,GO:0007612,GO:0008046,GO:0009986,GO:0010628,GO:0016310,GO:0018108,GO:0021631,GO:0021934,GO:0021952,GO:0022038,GO:0030193,GO:0030335,GO:0030424,GO:0030425,GO:0030890,GO:0031290,GO:0031915,GO:0032760,GO:0042113,GO:0042472,GO:0042734,GO:0042802,GO:0043025,GO:0043197,GO:0044877,GO:0045211,GO:0046425,GO:0046580,GO:0048013,GO:0048168,GO:0048170,GO:0048593,GO:0050771,GO:0050878,GO:0051489,GO:0051965,GO:0060021,GO:0060996,GO:0060997,GO:0061003,GO:0070373,GO:0071222,GO:0071679,GO:0097104,GO:0098686,GO:0098794,GO:0098978,GO:0099557,GO:0106028,GO:0110077,GO:0120192,GO:1900016,GO:1900273,GO:1903078,GO:1904646,GO:1904782,GO:1904783,GO:2000010,GO:2000316,GO:2000785,GO:2000822","angiogenesis|amyloid-beta binding|urogenital system development|negative regulation of protein phosphorylation|positive regulation of immunoglobulin production|protein tyrosine kinase activity|transmembrane-ephrin receptor activity|signaling receptor binding|protein binding|ATP binding|extracellular region|nucleoplasm|cytosol|plasma membrane|protein phosphorylation|negative regulation of protein kinase activity|negative regulation of cell adhesion|nervous system development|axon guidance|axonal fasciculation|learning or memory|learning|axon guidance receptor activity|cell surface|positive regulation of gene expression|phosphorylation|peptidyl-tyrosine phosphorylation|optic nerve morphogenesis|hindbrain tangential cell migration|central nervous system projection neuron axonogenesis|corpus callosum development|regulation of blood coagulation|positive regulation of cell migration|axon|dendrite|positive regulation of B cell proliferation|retinal ganglion cell axon guidance|positive regulation of synaptic plasticity|positive regulation of tumor necrosis factor production|B cell activation|inner ear morphogenesis|presynaptic membrane|identical protein binding|neuronal cell body|dendritic spine|protein-containing complex binding|postsynaptic membrane|regulation of receptor signaling pathway via JAK-STAT|negative regulation of Ras protein signal transduction|ephrin receptor signaling pathway|regulation of neuronal synaptic plasticity|positive regulation of long-term neuronal synaptic plasticity|camera-type eye morphogenesis|negative regulation of axonogenesis|regulation of body fluid levels|regulation of filopodium assembly|positive regulation of synapse assembly|roof of mouth development|dendritic spine development|dendritic spine morphogenesis|positive regulation of dendritic spine morphogenesis|negative regulation of ERK1 and ERK2 cascade|cellular response to lipopolysaccharide|commissural neuron axon guidance|postsynaptic membrane assembly|hippocampal mossy fiber to CA3 synapse|postsynapse|glutamatergic synapse|trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission|neuron projection retraction|vesicle-mediated intercellular transport|tight junction assembly|negative regulation of cytokine production involved in inflammatory response|positive regulation of long-term synaptic potentiation|positive regulation of protein localization to plasma membrane|cellular response to amyloid-beta|negative regulation of NMDA glutamate receptor activity|positive regulation of NMDA glutamate receptor activity|positive regulation of protein localization to cell surface|regulation of T-helper 17 type immune response|regulation of autophagosome assembly|regulation of behavioral fear response","WP3,WP4357,WP2038,WP4564,WP288,WP4565,WP4331,WP3888,WP5191","Transcriptional activation by NRF2 in response to phytochemicals|NRF2-ARE regulation|Microtubule cytoskeleton regulation|Neural crest cell migration during development|Nod-like receptor (NLR) signaling pathway|Neural crest cell migration in cancer|Neovascularisation processes|VEGFA-VEGFR2 signaling|Resolvin E1 and resolvin D1 signaling pathways promoting inflammation resolution","R-HSA-1266738,R-HSA-1266738,R-HSA-2682334,R-HSA-2682334,R-HSA-373760,R-HSA-3928662,R-HSA-3928662,R-HSA-3928664,R-HSA-3928664,R-HSA-3928665,R-HSA-422475,R-HSA-422475,R-HSA-9675108,R-HSA-9675108","Developmental Biology|Developmental Biology|EPH-Ephrin signaling|EPH-Ephrin signaling|L1CAM interactions|EPHB-mediated forward signaling|EPHB-mediated forward signaling|Ephrin signaling|Ephrin signaling|EPH-ephrin mediated repulsion of cells|Axon guidance|Axon guidance|Nervous system development|Nervous system development"]
["EPOP",0.2815702973881,0.244188886286405,0.147724035086896,0.230330199475729,0.218492451044667,0.101097504645649,0.154530908646903,0.227382198882045,0.19992109439276,0.287140538371742,0.358259616816263,0.199964550909303,0.181139108612025,0.252652053201561,0.215648424754542,0.0942252045977766,0.398107036742528,0.727943310043132,0.420965590139254,0.350400430946914,0.570603659410607,0.606132552992774,0.359728303148149,0.323631142951454,0.410522545530105,0.54295375009855,0.272470405354251,0.67734274328703,100170841,"elongin BC and polycomb repressive complex 2 associated protein","protein_coding","hsa03083","Polycomb repressive complex","GO:0003682,GO:0005694,GO:0006357,GO:0035098,GO:0044877,GO:0048663,GO:0048863,GO:0070449","chromatin binding|chromosome|regulation of transcription by RNA polymerase II|ESC/E(Z) complex|protein-containing complex binding|neuron fate commitment|stem cell differentiation|elongin complex","WP5287","17q12 copy number variation syndrome"]
["ERAS",0,0,0,0.0312985221379936,0,0,0,0.128005717288318,0.0328260271513537,0.0314313442426695,0,0,0.0931057687965275,0,0,0,0,0,0,0,0,0.0310204311183843,0,0,0.0323547429951693,0.0310087808641397,0,0,3266,"ES cell expressed Ras","protein_coding",null,null,"GO:0003924,GO:0003925,GO:0005515,GO:0005525,GO:0005886,GO:0007265,GO:0019003","GTPase activity|G protein activity|protein binding|GTP binding|plasma membrane|Ras protein signal transduction|GDP binding","WP3931","Embryonic stem cell pluripotency pathways"]
["ERICH1",0.609786228137053,0.68704795384272,0.731377395073425,0.69693199175481,0.649561322366772,0.643071487261508,0.649502410843437,0.59367726052771,0.583527781681783,0.673003060385129,0.723604275020387,0.686342728600393,0.591515914384998,0.631258360413483,0.662019727256176,0.595539885370413,0.4864636081982,0.607801046522012,0.604696820786969,0.589738924772536,0.588721976166064,0.505823767744632,0.539985361849448,0.613642351635136,0.627908183183532,0.563657347435923,0.580792998825933,0.565068327067703,157697,"glutamate rich 1","protein_coding",null,null,"GO:0005515","protein binding"]
["ERVH48-1",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.00913553037399532,90625,"endogenous retrovirus group 48 member 1","protein_coding",null,null,"GO:0005515,GO:0005615,GO:0005886,GO:0006949","protein binding|extracellular space|plasma membrane|syncytium formation"]
["ETF1",48.236085956919,43.0404725046048,46.6361382090708,41.78412350057,45.8668175743242,40.9064208191605,44.5305494774923,42.7099247607709,42.9126724033132,32.5239840213045,39.8800458203426,40.9903810427195,43.569936434812,38.9164864791908,42.8528042912069,40.9558392205948,45.8389716728547,41.1138935367657,44.1357233337634,43.5382760333101,44.9822527109246,42.5054095251934,50.7258155681888,47.7589427474217,44.6966053763847,41.5864536459268,49.3179890406548,42.0695874233587,2107,"eukaryotic translation termination factor 1","protein_coding","hsa03015","mRNA surveillance pathway","GO:0000184,GO:0002184,GO:0003723,GO:0003747,GO:0004045,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0006415,GO:0006449,GO:0006479,GO:0008079,GO:0016149,GO:0018444,GO:0022626,GO:0043022,GO:1990825","nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|cytoplasmic translational termination|RNA binding|translation release factor activity|aminoacyl-tRNA hydrolase activity|protein binding|nucleus|cytoplasm|cytosol|translational termination|regulation of translational termination|protein methylation|translation termination factor activity|translation release factor activity, codon specific|translation release factor complex|cytosolic ribosome|ribosome binding|sequence-specific mRNA binding","WP107","Translation factors","R-HSA-1266738,R-HSA-376176,R-HSA-392499,R-HSA-392499,R-HSA-422475,R-HSA-72764,R-HSA-72764,R-HSA-72766,R-HSA-72766,R-HSA-8953854,R-HSA-9010553,R-HSA-927802,R-HSA-9675108,R-HSA-975956,R-HSA-975957","Developmental Biology|Signaling by ROBO receptors|Metabolism of proteins|Metabolism of proteins|Axon guidance|Eukaryotic Translation Termination|Eukaryotic Translation Termination|Translation|Translation|Metabolism of RNA|Regulation of expression of SLITs and ROBOs|Nonsense-Mediated Decay (NMD)|Nervous system development|Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)|Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"]
["EVI5L",9.90397454453974,10.510820624165,9.03884161287187,11.8234317257184,9.85321523898588,10.5066566496575,9.35630607611467,10.1046132424023,11.1569467778096,15.3192812357819,13.691879664302,11.8264327833616,11.8816128902477,11.964105184088,9.63456163632417,10.6019349074124,11.3282107007038,12.7360188790308,10.9088360002734,11.7952556498055,13.0961629690034,12.2567024559998,9.30694238994458,10.1752268154171,11.6609544368329,12.9477192305218,9.51037764386498,12.9534237019315,115704,"ecotropic viral integration site 5 like","protein_coding",null,null,"GO:0005096,GO:0005515,GO:0031267,GO:0043547,GO:0090630,GO:1902018","GTPase activator activity|protein binding|small GTPase binding|positive regulation of GTPase activity|activation of GTPase activity|negative regulation of cilium assembly"]
["EXO5",4.31733346624819,3.30170888499928,2.83117657756606,3.141842633548,2.92554211445723,3.40226510217028,2.56053362644576,2.51035437679232,2.70597424945694,2.70592885280131,2.50957241687766,3.1212776555667,2.55835419536298,2.09939177482054,1.55357984875983,1.71761931057285,3.09749703151137,2.78021461972144,2.72695148992639,2.43048237458024,3.30703517751017,2.68086430059727,2.49518329094662,3.51846308794686,3.64578712476834,3.2879789557407,2.92866180933171,3.30414303719035,64789,"exonuclease 5","protein_coding",null,null,"GO:0003677,GO:0005634,GO:0005654,GO:0005829,GO:0008310,GO:0036297,GO:0045145,GO:0046872,GO:0051539","DNA binding|nucleus|nucleoplasm|cytosol|single-stranded DNA 3'-5' DNA exonuclease activity|interstrand cross-link repair|single-stranded DNA 5'-3' DNA exonuclease activity|metal ion binding|4 iron, 4 sulfur cluster binding"]
["EXTL3",11.7860787743935,10.7590243422896,8.89762748026652,10.0833730420651,11.5294812661339,10.3672778287587,9.16459177921733,9.90136030173194,12.7808773730614,14.5548057992337,12.5174701760943,12.5919819158337,11.8963178450111,12.2617289744565,11.8318602956635,11.9955130420845,10.3039953638169,10.6094575301365,9.23065205891192,11.0480708686925,9.45414020109073,10.0797227030224,7.37655932910735,8.84894984939832,10.6221380899718,9.65559501334738,8.05236387587088,8.9036861964709,2137,"exostosin like glycosyltransferase 3","protein_coding","hsa00534","Glycosaminoglycan biosynthesis - heparan sulfate / heparin","GO:0000287,GO:0001888,GO:0005515,GO:0005634,GO:0005783,GO:0005789,GO:0005794,GO:0005886,GO:0015012,GO:0016500,GO:0016757,GO:0030307,GO:0045617,GO:0050728,GO:0051897,GO:0106015,GO:1900016,GO:2000972","magnesium ion binding|glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|protein binding|nucleus|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|plasma membrane|heparan sulfate proteoglycan biosynthetic process|protein-hormone receptor activity|glycosyltransferase activity|positive regulation of cell growth|negative regulation of keratinocyte differentiation|negative regulation of inflammatory response|positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction|negative regulation of inflammatory response to wounding|negative regulation of cytokine production involved in inflammatory response|positive regulation of detection of glucose","WP4784,WP5395","Proteoglycan biosynthesis|Glycosaminoglycan synthesis in fibroblasts","R-HSA-2262752,R-HSA-381038,R-HSA-381070,R-HSA-381119,R-HSA-8953897","Cellular responses to stress|XBP1(S) activates chaperone genes|IRE1alpha activates chaperones|Unfolded Protein Response (UPR)|Cellular responses to stimuli"]
["F2RL1",2.4154636569888,2.02419734684783,1.65231915398047,1.8256984705624,2.0356399354861,1.98155098501187,1.55825529683701,1.60254459455259,1.80641561805584,1.08968973464359,0.89513017111864,1.10215304812893,1.0674184574996,0.941685414398933,0.926939827090747,1.17491171589149,5.47342803807097,3.47288610474275,3.94201092032011,4.0669905872363,4.33084756151588,3.49092482559901,4.96421136650147,4.48282227037698,4.54912859822086,3.77117182653248,4.06655432939163,3.7481115250878,2150,"F2R like trypsin receptor 1","protein_coding","hsa04080,hsa04750,hsa05143","Neuroactive ligand-receptor interaction|Inflammatory mediator regulation of TRP channels|African trypanosomiasis","GO:0001965,GO:0002020,GO:0002286,GO:0002690,GO:0002720,GO:0003104,GO:0004930,GO:0005102,GO:0005515,GO:0005769,GO:0005794,GO:0005886,GO:0006954,GO:0007186,GO:0007200,GO:0007204,GO:0007596,GO:0010804,GO:0015057,GO:0030193,GO:0030335,GO:0030836,GO:0031143,GO:0031274,GO:0031681,GO:0032682,GO:0032722,GO:0032729,GO:0032731,GO:0032733,GO:0032755,GO:0032757,GO:0032930,GO:0034137,GO:0034140,GO:0034141,GO:0034145,GO:0035025,GO:0038023,GO:0042119,GO:0042311,GO:0043122,GO:0043123,GO:0043311,GO:0043547,GO:0045087,GO:0045217,GO:0045944,GO:0046328,GO:0046329,GO:0046330,GO:0046676,GO:0050900,GO:0050921,GO:0050927,GO:0051607,GO:0051897,GO:0060100,GO:0061028,GO:0070374,GO:0070493,GO:0070661,GO:0070963,GO:0097029,GO:0099109,GO:1900135,GO:2000341","G-protein alpha-subunit binding|protease binding|T cell activation involved in immune response|positive regulation of leukocyte chemotaxis|positive regulation of cytokine production involved in immune response|positive regulation of glomerular filtration|G protein-coupled receptor activity|signaling receptor binding|protein binding|early endosome|Golgi apparatus|plasma membrane|inflammatory response|G protein-coupled receptor signaling pathway|phospholipase C-activating G protein-coupled receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|blood coagulation|negative regulation of tumor necrosis factor-mediated signaling pathway|thrombin-activated receptor activity|regulation of blood coagulation|positive regulation of cell migration|positive regulation of actin filament depolymerization|pseudopodium|positive regulation of pseudopodium assembly|G-protein beta-subunit binding|negative regulation of chemokine production|positive regulation of chemokine production|positive regulation of type II interferon production|positive regulation of interleukin-1 beta production|positive regulation of interleukin-10 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of superoxide anion generation|positive regulation of toll-like receptor 2 signaling pathway|negative regulation of toll-like receptor 3 signaling pathway|positive regulation of toll-like receptor 3 signaling pathway|positive regulation of toll-like receptor 4 signaling pathway|positive regulation of Rho protein signal transduction|signaling receptor activity|neutrophil activation|vasodilation|regulation of canonical NF-kappaB signal transduction|positive regulation of canonical NF-kappaB signal transduction|positive regulation of eosinophil degranulation|positive regulation of GTPase activity|innate immune response|cell-cell junction maintenance|positive regulation of transcription by RNA polymerase II|regulation of JNK cascade|negative regulation of JNK cascade|positive regulation of JNK cascade|negative regulation of insulin secretion|leukocyte migration|positive regulation of chemotaxis|positive regulation of positive chemotaxis|defense response to virus|positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction|positive regulation of phagocytosis, engulfment|establishment of endothelial barrier|positive regulation of ERK1 and ERK2 cascade|thrombin-activated receptor signaling pathway|leukocyte proliferation|positive regulation of neutrophil mediated killing of gram-negative bacterium|mature conventional dendritic cell differentiation|potassium channel activating, G protein-coupled receptor signaling pathway|positive regulation of renin secretion into blood stream|regulation of chemokine (C-X-C motif) ligand 2 production","WP455","GPCRs, class A rhodopsin-like","R-HSA-162582,R-HSA-372790,R-HSA-373076,R-HSA-375276,R-HSA-388396,R-HSA-416476,R-HSA-500792","Signal Transduction|Signaling by GPCR|Class A/1 (Rhodopsin-like receptors)|Peptide ligand-binding receptors|GPCR downstream signalling|G alpha (q) signalling events|GPCR ligand binding"]
["FAAH2",0.0479434686264884,0.00760036551358308,0.0637656461860898,0.0114951441911884,0.0234241696935392,0.0487731403025922,0.022365411633867,0.0391776798874134,0.0281310343840414,0.0346317790277168,0.0225440302499069,0.0401959274004362,0.0303958757080902,0.0571352846522818,0.0483027540996445,0.0378814091405764,0.0345710557028971,0.0443604029709652,0.044310376196395,0.015367818730644,0.0150838417186453,0.0379766949811552,0.0276096089414506,0.0429361681983726,0.0158440893517177,0.0265737025280059,0.0231970070208482,0.033804305812534,158584,"fatty acid amide hydrolase 2","protein_coding",null,null,"GO:0005811,GO:0016020,GO:0016042,GO:0017064,GO:0019369","lipid droplet|membrane|lipid catabolic process|fatty acid amide hydrolase activity|arachidonic acid metabolic process",null,null,"R-HSA-1430728,R-HSA-2142753,R-HSA-556833,R-HSA-8978868","Metabolism|Arachidonic acid metabolism|Metabolism of lipids|Fatty acid metabolism"]
["FAM110A",2.4813252517797,2.62835108774802,1.90600114858869,3.13692384641632,2.69099033973945,3.15974442625601,2.09582544852362,2.60829501934125,2.4202442110588,3.27696970177444,3.06719470695922,2.57206843899728,1.92174029295389,1.98032729396366,1.70449101417521,1.51497899128834,2.97301837595808,3.24380419831541,1.86764450436923,2.59397447210713,2.78556429077491,3.52895260146278,1.3454320866485,2.15789358457236,3.24278457617692,3.59907285791252,1.41885124323962,3.42841037932205,83541,"family with sequence similarity 110 member A","protein_coding",null,null,"GO:0000922,GO:0005515,GO:0005634,GO:0005813,GO:0005829,GO:0005876,GO:0005938,GO:0007052","spindle pole|protein binding|nucleus|centrosome|cytosol|spindle microtubule|cell cortex|mitotic spindle organization","WP4754","IL-18 signaling pathway"]
["FAM133A",0.00802985261699229,0,0.0113080695688784,0,0.0156928679299284,0.0037702204076624,0.0037458899884247,0.0236221453262179,0.0121154148467462,0,0.0302064486339235,0,0,0.0229664441792639,0.00746771801540527,0.00380676001595872,0.00772021688767905,3.7148699092084E-3,0,0,0.0113684852631479,0.0190816771699325,0.0118908484315056,0.00392247307978471,0.00398049116979592,0.00381490214384561,0,0.0150979810887477,286499,"family with sequence similarity 133 member A","protein_coding",null,null,"GO:0005515","protein binding"]
["FAM167B",0.740086162741627,1.02884229808105,1.3896387583398,0.76438460402061,0.472849144610921,0.534598940169912,0.584263905396236,0.78155127493248,0.458108526750043,0.328983615769103,0.535390961267589,0.601398137865429,0.649675734115579,0.786994804710975,0.555915223793057,0.269890039568605,0.355774007597889,0.684775660856447,0.342001707722809,0.547448114971779,0.402998997131864,0.622308500936711,0.309111833882583,0.19466567033128,0.451531450289501,0.351607485659063,0.275449148837843,0.535205095194573,84734,"family with sequence similarity 167 member B","protein_coding"]
["FAM174C",28.9701853390256,27.5554527714572,35.4886216414745,34.8861242318894,28.126787154181,29.415753649463,34.5160770418924,33.0566672581622,26.2104884794509,35.5713219431937,39.337389335204,28.6788239536878,22.7769529367989,26.703797398946,27.4319668592933,24.2365908809151,29.1638114505837,28.9552332599189,41.4652425928513,28.5436300892751,31.437781919936,33.6631579156629,28.3246570106565,26.6987323164011,28.015190982962,34.5337307605785,29.3531593938505,39.4985051323217,55009,"family with sequence similarity 174 member C","protein_coding",null,null,"GO:0005576,GO:0005737,GO:0016020","extracellular region|cytoplasm|membrane"]
["FAM200A",2.76372477000583,3.06563221370432,2.86976481854519,2.30880849087507,2.52261929948456,2.76631394005313,2.43815181438118,2.22864948235924,2.62062402540804,2.07454258921535,2.97893795722918,2.46185058609752,3.56210709530608,2.45367849203696,3.15941730406579,3.18356074641312,2.39829081931864,2.461924173814,3.76922947810162,3.15263532696248,3.04205837182799,2.83778621948505,3.81507601920632,3.35769687656603,2.56729753010611,2.55079105901622,3.59397213020818,2.68755817095891,221786,"family with sequence similarity 200 member A","protein_coding",null,null,"GO:0005515,GO:0016020","protein binding|membrane"]
["FAM228A",0.0295572535474156,0.0421707780593298,0.083248222681414,0.0283471264100688,0.0722052599243005,0.055511534686503,0.234401530426984,0.0724593766996651,0.163518247092763,0.241973100798007,0.194578217228226,0.0743426321739977,0.154597773261193,0.12680650182531,0.316112925267246,0.210185746275879,0.0710437721818492,0.0410224285697783,0.327809329163462,0.156325850155181,0.153437154719394,0.196666812200107,0.175077097300721,0.101068196164321,0.131866863720443,0.196592950610149,0.314622125377611,0.0416808573313536,653140,"family with sequence similarity 228 member A","protein_coding",null,null,"GO:0005515","protein binding"]
["FAM27C",0,0.0364720242675285,0,0.0367746504779271,0,0,0,0,0.0385694145476788,0,0.0721216558066013,0,0,0.0731136587100892,0,0,0.0737319149130543,0,0.177194231980249,0.0737458556014616,0.0361915647495377,0,0,0,0,0.0728684295697851,0.18552656041923,0.0720966180866658,100132948,"family with sequence similarity 27 member C","non_coding"]
["FAM66E",0,0.0536398181173065,0.0176481587832286,0.126198085775369,0.0183685347422488,0.0353044069972738,0.0350765765443284,0.0552995410461042,0.0378163157977938,0.0362096099643585,0.0176783556597073,0.0567368038014107,0.089383269439716,0.0358430279450437,0.0174819591197458,0.0534698467513533,0,0.0695722080067648,0.0173734372499464,0.0542294314726229,0.0177424477119421,0,0.0185576839537724,0.0183650517835945,0,0.0178614037613524,0,0,100132103,"family with sequence similarity 66 member E","non_coding"]
["FAM72C",0.480700683207353,0.202234622901806,0.078109443503549,0.15958382275298,0.234860236395749,0.156254690228675,0.00862479608445935,0.199427288628543,0.120879931258997,0.124647484506937,0.095630446562491,0.102305251847674,0.13186790985242,0.00881325481364758,0.0687767609813868,0.113944316773974,0.186643391608611,0.213834332736841,0.111068455834533,0.400025744504842,0.174503909594821,0.202100874618335,0.146017661397583,0.225784330055509,0.164969245148209,0.193241277730846,0.161018730832986,0.269410424890725,554282,"family with sequence similarity 72 member C","protein_coding",null,null,"GO:0005829,GO:0043231","cytosol|intracellular membrane-bounded organelle"]
["FAM9C",0,0,0,0,0,0,0,0,0,0,0.0068000971073016,0,0,6.89362956990245E-3,0,0,0,0,0.00668280821255985,0,6.82475054155713E-3,0.00687308908363343,0,0,0,0,0,0.0271909455552178,171484,"family with sequence similarity 9 member C","protein_coding",null,null,"GO:0000795,GO:0005515,GO:0007286,GO:0051321","synaptonemal complex|protein binding|spermatid development|meiotic cell cycle"]
["FAT2",0.00682738307737431,0.00649397405434623,0,0.0114587510290558,0.00667143134816307,0,0.00636988675546975,0.00669491056038443,0.00515056640796901,9.8634674898164E-3,0,6.86891463738982E-3,0,0.00650907390276612,0,0,0,0.00157928427597196,1.57750326197829E-3,0.00164133908971783,0,0,0.00168503253274929,0.0066701663414613,0,0.00973086291158594,0,0.00641853004684684,2196,"FAT atypical cadherin 2","protein_coding",null,null,"GO:0005509,GO:0005794,GO:0005886,GO:0005912,GO:0007156,GO:0010631,GO:0031589,GO:0070062,GO:0098609","calcium ion binding|Golgi apparatus|plasma membrane|adherens junction|homophilic cell adhesion via plasma membrane adhesion molecules|epithelial cell migration|cell-substrate adhesion|extracellular exosome|cell-cell adhesion"]
["FBN1-DT",0.104481454400167,0.241349480631912,0.294272787152905,0.200407591364207,0.306284637446335,0.210243021736257,0.0835545029311743,0.160999438992478,0.480430536912836,0.273135944930485,0.350924169656981,0.450501531845088,0.411638166436327,0.369981022675252,0.541359936728075,0.43871328303519,0.344408878298187,0.220966879915173,0.400050809233815,0.502357911703755,0.352196428833402,0.184439307502331,0.427319958417265,0.481213167499037,0.473532982751005,0.326193144439051,0.375532056627097,0.238545593231933,105370809,null,"non_coding"]
["FBXL22",0.0579607671283758,0.0508895131857212,0.104645466817523,0.0684156911306193,0.0609935004110797,0.0418677800480406,0.095674466389765,0.0918122383428373,0.0358773383089886,0.0944707885507429,0.0251578848984654,0.0403707790197931,0.0593601891257605,0.051007841951564,0.0497567900318534,0.0465009021201812,0.0214329871749409,0.0783809286864172,0.0288446184444197,0.0257244474799012,0.0336654581791928,0.055093845410058,0.0264092478892256,0.00871170501411663,0.0397825271958466,0.0762551362699355,0.0172577137908989,0.0586813525644199,283807,"F-box and leucine rich repeat protein 22","protein_coding",null,null,"GO:0005515,GO:0005730,GO:0005829,GO:0016567,GO:0030018,GO:0043161,GO:0061630","protein binding|nucleolus|cytosol|protein ubiquitination|Z disc|proteasome-mediated ubiquitin-dependent protein catabolic process|ubiquitin protein ligase activity",null,null,"R-HSA-1280218,R-HSA-168256,R-HSA-392499,R-HSA-597592,R-HSA-8951664,R-HSA-983168,R-HSA-983169","Adaptive Immune System|Immune System|Metabolism of proteins|Post-translational protein modification|Neddylation|Antigen processing: Ubiquitination & Proteasome degradation|Class I MHC mediated antigen processing & presentation"]
["FBXO42",4.61598841296436,4.74433213299211,4.39961050042924,4.22487345069103,4.66803518570671,4.61793334083765,4.04449651173008,4.12929803032631,5.0296337722968,5.50449908728614,5.27768431975404,5.20534733340136,4.24435557402045,4.97599366230587,4.36586401549667,4.96047383441483,4.39428874899342,4.80249816533099,4.27383360254139,4.92762051547648,4.99258280303909,5.05936906663738,4.12863090835293,3.98080445777512,4.65833897605844,4.55486332558396,3.9469460290985,4.82907524804945,54455,"F-box protein 42","protein_coding",null,null,"GO:0005515,GO:0019005,GO:1990756","protein binding|SCF ubiquitin ligase complex|ubiquitin ligase-substrate adaptor activity"]
["FCGBP",0.0252202232046559,0.0399810276938601,0.0177582361809097,0.0463596852937473,0.0554493160884446,0.0217094852633322,0.0431387742406234,0.045339932452895,0.0613063039438272,0.0789434994100544,0.0790605395790437,0.0380604599958941,0.0939381505332603,0.0641183871176581,0.105545999251258,0.0757232415711509,0.0101032153796735,0.0116676921427219,0.00388484469303339,0.0121261507456325,0.0198367924675853,0.025970481003369,0.0269727385206787,0.00615986689326553,0.020836595753945,0.021966769291406,0.0122025733954204,0.0079033092959498,8857,"Fc gamma binding protein","protein_coding",null,null,"GO:0005515,GO:0005615,GO:0031012,GO:0070062","protein binding|extracellular space|extracellular matrix|extracellular exosome"]
["FEN1",29.5101026905662,23.5031803050664,9.91710970196845,23.3647814777086,19.2196648535645,17.6037650116555,6.51202907219839,16.4027326168984,16.7581427778098,22.3049042046522,14.8382436403293,20.6630035939614,14.0382809174319,6.71806086125311,4.11601280953563,5.67968594381042,26.7523781742679,26.463373325466,16.5472165540627,22.9514770909653,26.2882349451492,25.2161637846777,16.2099160088112,24.4805047117471,25.0281911924854,25.1558734760334,16.1608174401214,24.7134403929426,2237,"flap structure-specific endonuclease 1","protein_coding","hsa03030,hsa03410,hsa03450","DNA replication|Base excision repair|Non-homologous end-joining","GO:0000287,GO:0000724,GO:0000781,GO:0003677,GO:0003684,GO:0003690,GO:0004519,GO:0004523,GO:0004527,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005739,GO:0006260,GO:0006281,GO:0006287,GO:0006302,GO:0007613,GO:0008309,GO:0008409,GO:0009650,GO:0016020,GO:0017108,GO:0030145,GO:0032201,GO:0032991,GO:0043137,GO:0045876,GO:0048256,GO:0090305","magnesium ion binding|double-strand break repair via homologous recombination|chromosome, telomeric region|DNA binding|damaged DNA binding|double-stranded DNA binding|endonuclease activity|RNA-DNA hybrid ribonuclease activity|exonuclease activity|protein binding|nucleus|nucleoplasm|nucleolus|mitochondrion|DNA replication|DNA repair|base-excision repair, gap-filling|double-strand break repair|memory|double-stranded DNA exodeoxyribonuclease activity|5'-3' exonuclease activity|UV protection|membrane|5'-flap endonuclease activity|manganese ion binding|telomere maintenance via semi-conservative replication|protein-containing complex|DNA replication, removal of RNA primer|positive regulation of sister chromatid cohesion|flap endonuclease activity|nucleic acid phosphodiester bond hydrolysis","WP5413,WP4016,WP4946,WP4752","IL-24 Signaling pathway|DNA IR-damage and cellular response via ATR|DNA repair pathways, full network|Base excision repair","R-HSA-110362,R-HSA-110373,R-HSA-157579,R-HSA-162587,R-HSA-162594,R-HSA-162906,R-HSA-1640170,R-HSA-1643685,R-HSA-174414,R-HSA-174417,R-HSA-174437,R-HSA-180786,R-HSA-5651801,R-HSA-5663205,R-HSA-5685939,R-HSA-5693532,R-HSA-5693538,R-HSA-69166,R-HSA-69183,R-HSA-69186,R-HSA-69190,R-HSA-69239,R-HSA-69242,R-HSA-69278,R-HSA-69306,R-HSA-73884,R-HSA-73886,R-HSA-73894,R-HSA-73933,R-HSA-9824446","POLB-Dependent Long Patch Base Excision Repair|Resolution of AP sites via the multiple-nucleotide patch replacement pathway|Telomere Maintenance|HIV Life Cycle|Early Phase of HIV Life Cycle|HIV Infection|Cell Cycle|Disease|Processive synthesis on the C-strand of the telomere|Telomere C-strand (Lagging Strand) Synthesis|Removal of the Flap Intermediate from the C-strand|Extension of Telomeres|PCNA-Dependent Long Patch Base Excision Repair|Infectious disease|HDR through MMEJ (alt-NHEJ)|DNA Double-Strand Break Repair|Homology Directed Repair|Removal of the Flap Intermediate|Processive synthesis on the lagging strand|Lagging Strand Synthesis|DNA strand elongation|Synthesis of DNA|S Phase|Cell Cycle, Mitotic|DNA Replication|Base Excision Repair|Chromosome Maintenance|DNA Repair|Resolution of Abasic Sites (AP sites)|Viral Infection Pathways"]
["FER1L6",0.0640130095575077,0.0288412070417013,0.0253042966580676,0.0355428536615186,0.0427979283420826,0.0316376200687981,0.0220034167824002,0.00330373461067839,0.0338886369541534,0.0519180909275242,0.00316844919585306,0.00677920065418681,0.0416518662390997,0.00642405975168012,0.00313324951602493,0.0351386644442714,0.0194351466756194,0.0342904639763376,0.00311379940212762,0.019438821330269,0.0572388526859955,0.0320245920557248,0.0565428345738113,0.023040668641885,0.00668041937608045,0.0224087952701482,0.00978066531493955,0.0158367461926403,654463,"fer-1 like family member 6","protein_coding",null,null,"GO:0009617,GO:0010628,GO:0016020,GO:0046872","response to bacterium|positive regulation of gene expression|membrane|metal ion binding"]
["FGF2",18.0318180732283,14.4983321702048,10.1790151541377,9.39087787790459,16.7257180642502,11.9710235356182,10.0748108055376,9.81246483533507,10.0533014979586,5.51435214843637,5.19363212962896,7.26140644749415,10.6248592862394,6.23994050999276,8.02582164136752,8.66917082582193,8.20920801849449,6.89162268041859,7.56414583716345,9.60727807534575,9.33586386229484,8.08964309756414,11.6855886936363,9.13481741779118,8.1535958103112,6.92597483167586,8.83233489328429,6.19802653927915,2247,"fibroblast growth factor 2","protein_coding","hsa04010,hsa04014,hsa04015,hsa04020,hsa04151,hsa04550,hsa04810,hsa05200,hsa05205,hsa05207,hsa05226,hsa05218,hsa05224,hsa05167,hsa01521","MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|Calcium signaling pathway|PI3K-Akt signaling pathway|Signaling pathways regulating pluripotency of stem cells|Regulation of actin cytoskeleton|Pathways in cancer|Proteoglycans in cancer|Chemical carcinogenesis - receptor activation|Gastric cancer|Melanoma|Breast cancer|Kaposi sarcoma-associated herpesvirus infection|EGFR tyrosine kinase inhibitor resistance","GO:0001649,GO:0001658,GO:0001759,GO:0001935,GO:0001938,GO:0002042,GO:0002052,GO:0005104,GO:0005125,GO:0005178,GO:0005515,GO:0005576,GO:0005615,GO:0005634,GO:0005737,GO:0006366,GO:0006661,GO:0006935,GO:0007165,GO:0007265,GO:0007399,GO:0007405,GO:0008083,GO:0008201,GO:0008284,GO:0008543,GO:0009792,GO:0009887,GO:0010001,GO:0010595,GO:0010628,GO:0010629,GO:0010764,GO:0010863,GO:0014843,GO:0019956,GO:0021762,GO:0021930,GO:0021940,GO:0030154,GO:0030214,GO:0030324,GO:0030374,GO:0032958,GO:0038001,GO:0040037,GO:0042056,GO:0042060,GO:0042491,GO:0042660,GO:0042802,GO:0043406,GO:0043410,GO:0043491,GO:0043536,GO:0043537,GO:0043552,GO:0045609,GO:0045669,GO:0045765,GO:0045766,GO:0045893,GO:0045944,GO:0046668,GO:0048598,GO:0048678,GO:0048864,GO:0050679,GO:0050918,GO:0051209,GO:0051726,GO:0051781,GO:0051897,GO:0060045,GO:0060070,GO:0060128,GO:0060129,GO:0060591,GO:0060644,GO:0060978,GO:0061045,GO:0070371,GO:0070374,GO:0071260,GO:0072089,GO:0090049,GO:0090050,GO:0090263,GO:0090722,GO:1902748,GO:1902895,GO:1902913,GO:1903587,GO:1903672,GO:1904707,GO:1904977,GO:1905278,GO:1905564,GO:2000544,GO:2000546,GO:2000573,GO:2000647,GO:2000648,GO:2000738,GO:2001028","osteoblast differentiation|branching involved in ureteric bud morphogenesis|organ induction|endothelial cell proliferation|positive regulation of endothelial cell proliferation|cell migration involved in sprouting angiogenesis|positive regulation of neuroblast proliferation|fibroblast growth factor receptor binding|cytokine activity|integrin binding|protein binding|extracellular region|extracellular space|nucleus|cytoplasm|transcription by RNA polymerase II|phosphatidylinositol biosynthetic process|chemotaxis|signal transduction|Ras protein signal transduction|nervous system development|neuroblast proliferation|growth factor activity|heparin binding|positive regulation of cell population proliferation|fibroblast growth factor receptor signaling pathway|embryo development ending in birth or egg hatching|animal organ morphogenesis|glial cell differentiation|positive regulation of endothelial cell migration|positive regulation of gene expression|negative regulation of gene expression|negative regulation of fibroblast migration|positive regulation of phospholipase C activity|growth factor dependent regulation of skeletal muscle satellite cell proliferation|chemokine binding|substantia nigra development|cerebellar granule cell precursor proliferation|positive regulation of cerebellar granule cell precursor proliferation|cell differentiation|hyaluronan catabolic process|lung development|nuclear receptor coactivator activity|inositol phosphate biosynthetic process|paracrine signaling|negative regulation of fibroblast growth factor receptor signaling pathway|chemoattractant activity|wound healing|inner ear auditory receptor cell differentiation|positive regulation of cell fate specification|identical protein binding|positive regulation of MAP kinase activity|positive regulation of MAPK cascade|phosphatidylinositol 3-kinase/protein kinase B signal transduction|positive regulation of blood vessel endothelial cell migration|negative regulation of blood vessel endothelial cell migration|positive regulation of phosphatidylinositol 3-kinase activity|positive regulation of inner ear auditory receptor cell differentiation|positive regulation of osteoblast differentiation|regulation of angiogenesis|positive regulation of angiogenesis|positive regulation of DNA-templated transcription|positive regulation of transcription by RNA polymerase II|regulation of retinal cell programmed cell death|embryonic morphogenesis|response to axon injury|stem cell development|positive regulation of epithelial cell proliferation|positive chemotaxis|release of sequestered calcium ion into cytosol|regulation of cell cycle|positive regulation of cell division|positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction|positive regulation of cardiac muscle cell proliferation|canonical Wnt signaling pathway|corticotropin hormone secreting cell differentiation|thyroid-stimulating hormone-secreting cell differentiation|chondroblast differentiation|mammary gland epithelial cell differentiation|angiogenesis involved in coronary vascular morphogenesis|negative regulation of wound healing|ERK1 and ERK2 cascade|positive regulation of ERK1 and ERK2 cascade|cellular response to mechanical stimulus|stem cell proliferation|regulation of cell migration involved in sprouting angiogenesis|positive regulation of cell migration involved in sprouting angiogenesis|positive regulation of canonical Wnt signaling pathway|receptor-receptor interaction|positive regulation of lens fiber cell differentiation|positive regulation of miRNA transcription|positive regulation of neuroepithelial cell differentiation|regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis|positive regulation of sprouting angiogenesis|positive regulation of vascular associated smooth muscle cell proliferation|lymphatic endothelial cell migration|positive regulation of epithelial tube formation|positive regulation of vascular endothelial cell proliferation|regulation of endothelial cell chemotaxis to fibroblast growth factor|positive regulation of endothelial cell chemotaxis to fibroblast growth factor|positive regulation of DNA biosynthetic process|negative regulation of stem cell proliferation|positive regulation of stem cell proliferation|positive regulation of stem cell differentiation|positive regulation of endothelial cell chemotaxis","WP2064,WP5083,WP5115,WP1539,WP4304,WP3584,WP4262,WP4806,WP2406,WP4787,WP1544,WP4808,WP51,WP5365,WP5180,WP3624,WP3932,WP382,WP2848,WP474,WP2795,WP4155,WP5087,WP4172,WP3931","Neural crest differentiation|Neuroinflammation and glutamatergic signaling|Network map of SARS-CoV-2 signaling pathway|Angiogenesis|Oligodendrocyte specification and differentiation, leading to myelin components for CNS|MECP2 and associated Rett syndrome|Breast cancer pathway|EGFR tyrosine kinase inhibitor resistance|Cardiac progenitor differentiation|Osteoblast differentiation and related diseases|MicroRNAs in cardiomyocyte hypertrophy|Endochondral ossification with skeletal dysplasias|Regulation of actin cytoskeleton|4p16.3 copy number variation|DYRK1A involvement regarding cell proliferation in brain development|Lung fibrosis|Focal adhesion: PI3K-Akt-mTOR-signaling pathway|MAPK signaling pathway|Pluripotent stem cell differentiation pathway|Endochondral ossification|Cardiac hypertrophic response|Endometrial cancer|Pleural mesothelioma|PI3K-Akt signaling pathway|Embryonic stem cell pluripotency pathways","R-HSA-109704,R-HSA-112399,R-HSA-1226099,R-HSA-1226099,R-HSA-1257604,R-HSA-1266738,R-HSA-1266738,R-HSA-1280215,R-HSA-1474244,R-HSA-162582,R-HSA-1643685,R-HSA-1643685,R-HSA-168256,R-HSA-1839122,R-HSA-1839124,R-HSA-1839126,R-HSA-1839126,R-HSA-1839130,R-HSA-190236,R-HSA-190239,R-HSA-190241,R-HSA-190242,R-HSA-190322,R-HSA-190370,R-HSA-190372,R-HSA-190373,R-HSA-190375,R-HSA-190377,R-HSA-199418,R-HSA-2033514,R-HSA-2033519,R-HSA-2219528,R-HSA-2219530,R-HSA-2404192,R-HSA-2428924,R-HSA-2428928,R-HSA-2892247,R-HSA-3000170,R-HSA-3000171,R-HSA-449147,R-HSA-452723,R-HSA-5654219,R-HSA-5654221,R-HSA-5654227,R-HSA-5654228,R-HSA-5654687,R-HSA-5654688,R-HSA-5654689,R-HSA-5654693,R-HSA-5654695,R-HSA-5654696,R-HSA-5654699,R-HSA-5654700,R-HSA-5654704,R-HSA-5654706,R-HSA-5654708,R-HSA-5654710,R-HSA-5654712,R-HSA-5654716,R-HSA-5654719,R-HSA-5654720,R-HSA-5654726,R-HSA-5654727,R-HSA-5654732,R-HSA-5654733,R-HSA-5654736,R-HSA-5654738,R-HSA-5654741,R-HSA-5654743,R-HSA-5655253,R-HSA-5655253,R-HSA-5655302,R-HSA-5655332,R-HSA-5658623,R-HSA-5663202,R-HSA-5663202,R-HSA-5673001,R-HSA-5683057,R-HSA-5684996,R-HSA-6785807,R-HSA-6811558,R-HSA-74751,R-HSA-74752,R-HSA-8851708,R-HSA-9006925,R-HSA-9006934,R-HSA-9758941,R-HSA-9761174","PI3K Cascade|IRS-mediated signalling|Signaling by FGFR in disease|Signaling by FGFR in disease|PIP3 activates AKT signaling|Developmental Biology|Developmental Biology|Cytokine Signaling in Immune system|Extracellular matrix organization|Signal Transduction|Disease|Disease|Immune System|Signaling by activated point mutants of FGFR1|FGFR1 mutant receptor activation|FGFR2 mutant receptor activation|FGFR2 mutant receptor activation|Signaling by activated point mutants of FGFR3|Signaling by FGFR|FGFR3 ligand binding and activation|FGFR2 ligand binding and activation|FGFR1 ligand binding and activation|FGFR4 ligand binding and activation|FGFR1b ligand binding and activation|FGFR3c ligand binding and activation|FGFR1c ligand binding and activation|FGFR2c ligand binding and activation|FGFR2b ligand binding and activation|Negative regulation of the PI3K/AKT network|FGFR3 mutant receptor activation|Activated point mutants of FGFR2|PI3K/AKT Signaling in Cancer|Constitutive Signaling by Aberrant PI3K in Cancer|Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)|IGF1R signaling cascade|IRS-related events triggered by IGF1R|POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation|Syndecan interactions|Non-integrin membrane-ECM interactions|Signaling by Interleukins|Transcriptional regulation of pluripotent stem cells|Phospholipase C-mediated cascade: FGFR1|Phospholipase C-mediated cascade; FGFR2|Phospholipase C-mediated cascade; FGFR3|Phospholipase C-mediated cascade; FGFR4|Downstream signaling of activated FGFR1|SHC-mediated cascade:FGFR1|PI-3K cascade:FGFR1|FRS-mediated FGFR1 signaling|PI-3K cascade:FGFR2|Downstream signaling of activated FGFR2|SHC-mediated cascade:FGFR2|FRS-mediated FGFR2 signaling|SHC-mediated cascade:FGFR3|FRS-mediated FGFR3 signaling|Downstream signaling of activated FGFR3|PI-3K cascade:FGFR3|FRS-mediated FGFR4 signaling|Downstream signaling of activated FGFR4|SHC-mediated cascade:FGFR4|PI-3K cascade:FGFR4|Negative regulation of FGFR1 signaling|Negative regulation of FGFR2 signaling|Negative regulation of FGFR3 signaling|Negative regulation of FGFR4 signaling|Signaling by FGFR1|Signaling by FGFR2|Signaling by FGFR3|Signaling by FGFR4|Signaling by FGFR2 in disease|Signaling by FGFR2 in disease|Signaling by FGFR1 in disease|Signaling by FGFR3 in disease|FGFRL1 modulation of FGFR1 signaling|Diseases of signal transduction by growth factor receptors and second messengers|Diseases of signal transduction by growth factor receptors and second messengers|RAF/MAP kinase cascade|MAPK family signaling cascades|MAPK1/MAPK3 signaling|Interleukin-4 and Interleukin-13 signaling|PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling|Insulin receptor signalling cascade|Signaling by Insulin receptor|Signaling by FGFR2 IIIa TM|Intracellular signaling by second messengers|Signaling by Receptor Tyrosine Kinases|Gastrulation|Formation of intermediate mesoderm"]
["FHL3",17.8894206180749,24.6798876194176,30.9619041922546,27.5073941436604,18.4987783019973,27.8507001127153,29.1441234472234,27.8218803265253,26.9341913722493,42.3141435022085,42.4962049254061,32.5082014196211,24.6289121892627,33.1640862712599,29.1262107021284,31.1456691157865,25.0560058666628,28.4961210092056,26.6586581987329,26.610408221409,26.6410566502511,29.3053909061411,21.6782660913758,23.1707732870965,23.8201244842261,32.5115083290606,23.6907558756011,31.3866923545028,2275,"four and a half LIM domains 3","protein_coding",null,null,"GO:0001725,GO:0003712,GO:0003779,GO:0005515,GO:0005634,GO:0005925,GO:0006355,GO:0007517,GO:0030018,GO:0030036,GO:0046872","stress fiber|transcription coregulator activity|actin binding|protein binding|nucleus|focal adhesion|regulation of DNA-templated transcription|muscle organ development|Z disc|actin cytoskeleton organization|metal ion binding"]
["FKBP14",9.94748239998826,7.60232896678727,6.0447106423329,6.6682828049823,9.900167913407,7.23090708313349,6.25968918614889,7.14726016765185,9.86420137632181,5.80996212207951,5.69348170628982,8.6078553039328,10.716490198136,7.42898956240702,7.39282481448099,9.12366585971877,10.1990656271811,8.35730208908582,8.34287254527468,8.81586668078465,10.0022710379743,8.70395409632406,9.71878359977745,10.8611388471285,11.3224311689125,8.19130147973019,8.07493732475058,8.15544835967372,55033,"FKBP prolyl isomerase 14","protein_coding",null,null,"GO:0003755,GO:0005509,GO:0005515,GO:0005788","peptidyl-prolyl cis-trans isomerase activity|calcium ion binding|protein binding|endoplasmic reticulum lumen",null,null,"R-HSA-2262752,R-HSA-381038,R-HSA-381070,R-HSA-381119,R-HSA-8953897","Cellular responses to stress|XBP1(S) activates chaperone genes|IRE1alpha activates chaperones|Unfolded Protein Response (UPR)|Cellular responses to stimuli"]
["FLAD1",7.50712368914529,6.90938192893777,7.77312187674597,7.61594013093182,6.55543790346345,7.13921944614673,6.94739820283297,7.06359945738293,6.97499177179251,8.99401944965322,9.75343226308574,8.39975045486977,6.24783873413074,6.97509247387338,6.95736945382832,7.12612238346079,7.98530169477953,7.99802640828831,8.77507368447099,8.08695960346183,7.60986492195149,7.05330298413926,8.59354602256239,8.23301842054154,7.5029669821689,8.37832100504827,7.81879170048057,8.58330432802676,80308,"flavin adenine dinucleotide synthetase 1","protein_coding","hsa00740","Riboflavin metabolism","GO:0003919,GO:0005515,GO:0005524,GO:0005759,GO:0005829,GO:0005886,GO:0006747,GO:0006771,GO:0042802","FMN adenylyltransferase activity|protein binding|ATP binding|mitochondrial matrix|cytosol|plasma membrane|FAD biosynthetic process|riboflavin metabolic process|identical protein binding","WP15,WP176,WP5037","Selenium micronutrient network|Folate metabolism|Riboflavin and CoQ disorders","R-HSA-1430728,R-HSA-196843,R-HSA-196849,R-HSA-196854","Metabolism|Vitamin B2 (riboflavin) metabolism|Metabolism of water-soluble vitamins and cofactors|Metabolism of vitamins and cofactors"]
["FLJ22447",0.433506385362096,0.281138520395532,0.0554988151209427,0.170082758460413,0.154037887838507,0.074015379582004,0.0919221687948957,0.19322500453244,0.158563148696012,0.0759131296621201,0.111187552701843,0.019824701913066,0.149912992253278,0.0563584452556937,0.073301547888057,0.149465419573958,0.246285076897077,0.492269142837339,0.10926977638782,0.0947429394879889,0.167385986966611,0.412063796990701,0.116718064867147,0.077004339934721,0.253965811609742,0.131061967073432,0.0953400379932156,0.148198603844813,400221,"uncharacterized LOC400221","non_coding"]
["FLYWCH1",13.5000947426095,14.5709387937413,17.9325289075227,16.1564243083392,14.4534734740358,15.7743315662501,16.6198989149421,15.9430143232528,13.2977880614191,16.3019927804212,15.681155030227,13.8356015463051,14.1538718667034,16.9678119553502,14.5998029165488,14.9038058860717,11.8034101750472,13.3641009830856,14.4020255295888,13.535547069082,13.6627477589392,13.596122007911,11.4174258428933,12.5838544087539,12.3340138107665,13.2301587093777,12.0347830346537,13.732689668511,84256,"FLYWCH-type zinc finger 1","protein_coding",null,null,"GO:0000122,GO:0001223,GO:0003677,GO:0003714,GO:0005515,GO:0005654,GO:0005667,GO:0005721,GO:0005829,GO:0006974,GO:0016604,GO:0046872","negative regulation of transcription by RNA polymerase II|transcription coactivator binding|DNA binding|transcription corepressor activity|protein binding|nucleoplasm|transcription regulator complex|pericentric heterochromatin|cytosol|DNA damage response|nuclear body|metal ion binding"]
["FMO1",8.91409233969679E-3,0.00847878077383351,0,0,0,0,0,0.00874113115741991,0,0,0,0.0358732701284052,0.00847722277622704,0,0,0.00845191360686075,0,0,0,0,0,0,0,0,0,0,0,0,2326,"flavin containing dimethylaniline monoxygenase 1","protein_coding","hsa00430,hsa00982","Taurine and hypotaurine metabolism|Drug metabolism - cytochrome P450","GO:0000098,GO:0004497,GO:0004499,GO:0005515,GO:0005788,GO:0005789,GO:0006082,GO:0006805,GO:0009404,GO:0032496,GO:0034899,GO:0042412,GO:0046322,GO:0047822,GO:0050660,GO:0050661,GO:0070995,GO:0097009","sulfur amino acid catabolic process|monooxygenase activity|N,N-dimethylaniline monooxygenase activity|protein binding|endoplasmic reticulum lumen|endoplasmic reticulum membrane|organic acid metabolic process|xenobiotic metabolic process|toxin metabolic process|response to lipopolysaccharide|trimethylamine monooxygenase activity|taurine biosynthetic process|negative regulation of fatty acid oxidation|hypotaurine dehydrogenase activity|flavin adenine dinucleotide binding|NADP binding|NADPH oxidation|energy homeostasis","WP702,WP691,WP688","Metapathway biotransformation Phase I and II|Tamoxifen metabolism|Catalytic cycle of mammalian flavin-containing monooxygenases (FMOs)","R-HSA-1430728,R-HSA-1614558,R-HSA-1614635,R-HSA-211859,R-HSA-211945,R-HSA-217271,R-HSA-71291","Metabolism|Degradation of cysteine and homocysteine|Sulfur amino acid metabolism|Biological oxidations|Phase I - Functionalization of compounds|FMO oxidises nucleophiles|Metabolism of amino acids and derivatives"]
["FOS",225.578936143976,221.557892046187,247.661879811376,158.740243248864,248.506893813992,220.540573054305,215.017346966024,136.939956634226,259.377131388115,190.867256201462,215.553770183747,183.615559948775,324.496290674214,279.567031998867,373.89224328551,356.690486053457,59.8894137181584,125.040105772264,200.8947689984,25.5151021545368,22.3227988854256,45.0348839504746,69.4257245421656,59.44259255689,23.8670666752017,48.5483141345971,77.746792153371,22.8005383366813,2353,"Fos proto-oncogene%2C AP-1 transcription factor subunit","protein_coding","hsa04010,hsa04668,hsa04024,hsa04210,hsa04620,hsa04660,hsa04658,hsa04659,hsa04657,hsa04662,hsa04915,hsa04917,hsa04921,hsa04926,hsa04935,hsa04928,hsa04725,hsa04728,hsa04380,hsa04713,hsa05200,hsa05207,hsa05208,hsa05231,hsa05235,hsa05210,hsa05224,hsa05166,hsa05170,hsa05161,hsa05171,hsa05162,hsa05167,hsa05130,hsa05132,hsa05135,hsa05133,hsa05140,hsa05142,hsa05323,hsa05031,hsa05417,hsa05418,hsa04932,hsa01522","MAPK signaling pathway|TNF signaling pathway|cAMP signaling pathway|Apoptosis|Toll-like receptor signaling pathway|T cell receptor signaling pathway|Th1 and Th2 cell differentiation|Th17 cell differentiation|IL-17 signaling pathway|B cell receptor signaling pathway|Estrogen signaling pathway|Prolactin signaling pathway|Oxytocin signaling pathway|Relaxin signaling pathway|Growth hormone synthesis, secretion and action|Parathyroid hormone synthesis, secretion and action|Cholinergic synapse|Dopaminergic synapse|Osteoclast differentiation|Circadian entrainment|Pathways in cancer|Chemical carcinogenesis - receptor activation|Chemical carcinogenesis - reactive oxygen species|Choline metabolism in cancer|PD-L1 expression and PD-1 checkpoint pathway in cancer|Colorectal cancer|Breast cancer|Human T-cell leukemia virus 1 infection|Human immunodeficiency virus 1 infection|Hepatitis B|Coronavirus disease - COVID-19|Measles|Kaposi sarcoma-associated herpesvirus infection|Pathogenic Escherichia coli infection|Salmonella infection|Yersinia infection|Pertussis|Leishmaniasis|Chagas disease|Rheumatoid arthritis|Amphetamine addiction|Lipid and atherosclerosis|Fluid shear stress and atherosclerosis|Non-alcoholic fatty liver disease|Endocrine resistance","GO:0000785,GO:0000976,GO:0000978,GO:0000979,GO:0000981,GO:0001221,GO:0001228,GO:0001661,GO:0003682,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005783,GO:0005829,GO:0006306,GO:0006357,GO:0006366,GO:0006954,GO:0007179,GO:0007399,GO:0007565,GO:0009410,GO:0009416,GO:0009629,GO:0009636,GO:0014823,GO:0014856,GO:0030316,GO:0032496,GO:0032570,GO:0032868,GO:0032993,GO:0034224,GO:0034614,GO:0035902,GO:0035914,GO:0035976,GO:0035994,GO:0042802,GO:0045471,GO:0045672,GO:0045893,GO:0045944,GO:0051412,GO:0051450,GO:0051591,GO:0060395,GO:0061629,GO:0070412,GO:0071276,GO:0071277,GO:0071356,GO:0071364,GO:0071374,GO:0071456,GO:0090575,GO:0140467,GO:1902895,GO:1903131,GO:1904628,GO:1990646,GO:1990837","chromatin|transcription cis-regulatory region binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|RNA polymerase II core promoter sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|transcription coregulator binding|DNA-binding transcription activator activity, RNA polymerase II-specific|conditioned taste aversion|chromatin binding|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|endoplasmic reticulum|cytosol|DNA methylation|regulation of transcription by RNA polymerase II|transcription by RNA polymerase II|inflammatory response|transforming growth factor beta receptor signaling pathway|nervous system development|female pregnancy|response to xenobiotic stimulus|response to light stimulus|response to gravity|response to toxic substance|response to activity|skeletal muscle cell proliferation|osteoclast differentiation|response to lipopolysaccharide|response to progesterone|response to insulin|protein-DNA complex|cellular response to zinc ion starvation|cellular response to reactive oxygen species|response to immobilization stress|skeletal muscle cell differentiation|transcription factor AP-1 complex|response to muscle stretch|identical protein binding|response to ethanol|positive regulation of osteoclast differentiation|positive regulation of DNA-templated transcription|positive regulation of transcription by RNA polymerase II|response to corticosterone|myoblast proliferation|response to cAMP|SMAD protein signal transduction|RNA polymerase II-specific DNA-binding transcription factor binding|R-SMAD binding|cellular response to cadmium ion|cellular response to calcium ion|cellular response to tumor necrosis factor|cellular response to epidermal growth factor stimulus|cellular response to parathyroid hormone stimulus|cellular response to hypoxia|RNA polymerase II transcription regulator complex|integrated stress response signaling|positive regulation of miRNA transcription|mononuclear cell differentiation|cellular response to phorbol 13-acetate 12-myristate|cellular response to prolactin|sequence-specific double-stranded DNA binding","WP2849,WP5083,WP5115,WP5373,WP4816,WP2840,WP4216,WP3944,WP4630,WP4666,WP2374,WP3972,WP4262,WP289,WP2032,WP4685,WP1528,WP286,WP408,WP69,WP712,WP395,WP2355,WP3612,WP4564,WP127,WP4754,WP2435,WP3591,WP382,WP75,WP3863,WP2380,WP4970,WP481,WP560,WP2263,WP313,WP49,WP5130,WP437,WP4928,WP2037,WP4659,WP2431,WP2637,WP2526,WP4877,WP3611,WP4565,WP722,WP1772,WP2018,WP304,WP4155,WP4880,WP3947,WP5098,WP5094,WP4919,WP3931","Hematopoietic stem cell differentiation|Neuroinflammation and glutamatergic signaling|Network map of SARS-CoV-2 signaling pathway|Role of hypoxia, angiogenesis, and FGF pathway in OA chondrocyte hypertrophy|TGF-beta receptor signaling in skeletal dysplasias|Hair follicle development: cytodifferentiation - part 3 of 3|Chromosomal and microsatellite instability in colorectal cancer |Serotonin and anxiety-related events|Measles virus infection|Hepatitis B infection|Oncostatin M signaling pathway|PDGFR-beta pathway|Breast cancer pathway|Myometrial relaxation and contraction pathways|Thyroid stimulating hormone (TSH) signaling pathway|Melanoma|Physiological and pathological hypertrophy of the heart|IL-3 signaling pathway|Oxidative stress response|T-cell receptor signaling pathway|Estrogen signaling pathway|IL-4 signaling pathway|Corticotropin-releasing hormone signaling pathway|Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling|Neural crest cell migration during development|IL-5 signaling pathway|IL-18 signaling pathway|Quercetin and Nf-kB / AP-1 induced apoptosis|Sleep regulation|MAPK signaling pathway|Toll-like receptor signaling pathway|T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection|Brain-derived neurotrophic factor (BDNF) signaling pathway|Galanin receptor pathway|Insulin signaling|TGF-beta receptor signaling|Androgen receptor network in prostate cancer|Hepatocyte growth factor receptor signaling|IL-2 signaling pathway|Th17 cell differentiation pathway|EGF/EGFR signaling pathway|MAPK pathway in congenital thyroid cancer|Prolactin signaling pathway|Gastrin signaling pathway|Spinal cord injury|Interleukin-1 (IL-1) structural pathway|PDGF pathway|Host-pathogen interaction of human coronaviruses - MAPK signaling|Photodynamic therapy-induced AP-1 survival signaling|Neural crest cell migration in cancer|Serotonin HTR1 group and FOS pathway|Apoptosis modulation and signaling|RANKL/RANK signaling pathway|Kit receptor signaling pathway|Endometrial cancer|Host-pathogen interaction of human coronaviruses - interferon induction|Serotonin and anxiety|T-cell activation SARS-CoV-2|Orexin receptor pathway|Neuroinflammation|Embryonic stem cell pluripotency pathways","R-HSA-1280215,R-HSA-162582,R-HSA-162582,R-HSA-166016,R-HSA-166058,R-HSA-166166,R-HSA-166520,R-HSA-166520,R-HSA-168138,R-HSA-168142,R-HSA-168164,R-HSA-168176,R-HSA-168179,R-HSA-168181,R-HSA-168188,R-HSA-168249,R-HSA-168256,R-HSA-168898,R-HSA-181438,R-HSA-187037,R-HSA-187037,R-HSA-198725,R-HSA-198725,R-HSA-212436,R-HSA-212436,R-HSA-2262752,R-HSA-2454202,R-HSA-2559580,R-HSA-2559582,R-HSA-2559583,R-HSA-2871796,R-HSA-3700989,R-HSA-448424,R-HSA-449147,R-HSA-450282,R-HSA-450294,R-HSA-450341,R-HSA-6785807,R-HSA-6796648,R-HSA-73857,R-HSA-73857,R-HSA-74160,R-HSA-74160,R-HSA-8939211,R-HSA-8953897,R-HSA-9006931,R-HSA-9006934,R-HSA-9006934,R-HSA-9009391,R-HSA-9018519,R-HSA-9031628,R-HSA-9031628,R-HSA-937061,R-HSA-9634638,R-HSA-9634815,R-HSA-975138,R-HSA-975155,R-HSA-975871,R-HSA-9768919","Cytokine Signaling in Immune system|Signal Transduction|Signal Transduction|Toll Like Receptor 4 (TLR4) Cascade|MyD88:MAL(TIRAP) cascade initiated on plasma membrane|MyD88-independent TLR4 cascade |Signaling by NTRKs|Signaling by NTRKs|Toll Like Receptor 9 (TLR9) Cascade|Toll Like Receptor 10 (TLR10) Cascade|Toll Like Receptor 3 (TLR3) Cascade|Toll Like Receptor 5 (TLR5) Cascade|Toll Like Receptor TLR1:TLR2 Cascade|Toll Like Receptor 7/8 (TLR7/8) Cascade|Toll Like Receptor TLR6:TLR2 Cascade|Innate Immune System|Immune System|Toll-like Receptor Cascades|Toll Like Receptor 2 (TLR2) Cascade|Signaling by NTRK1 (TRKA)|Signaling by NTRK1 (TRKA)|Nuclear Events (kinase and transcription factor activation)|Nuclear Events (kinase and transcription factor activation)|Generic Transcription Pathway|Generic Transcription Pathway|Cellular responses to stress|Fc epsilon receptor (FCERI) signaling|Oxidative Stress Induced Senescence|Senescence-Associated Secretory Phenotype (SASP)|Cellular Senescence|FCERI mediated MAPK activation|Transcriptional Regulation by TP53|Interleukin-17 signaling|Signaling by Interleukins|MAPK targets/ Nuclear events mediated by MAP kinases|MAP kinase activation|Activation of the AP-1 family of transcription factors|Interleukin-4 and Interleukin-13 signaling|TP53 Regulates Transcription of DNA Repair Genes|RNA Polymerase II Transcription|RNA Polymerase II Transcription|Gene expression (Transcription)|Gene expression (Transcription)|ESR-mediated signaling|Cellular responses to stimuli|Signaling by Nuclear Receptors|Signaling by Receptor Tyrosine Kinases|Signaling by Receptor Tyrosine Kinases|Extra-nuclear estrogen signaling|Estrogen-dependent gene expression|NGF-stimulated transcription|NGF-stimulated transcription|TRIF(TICAM1)-mediated TLR4 signaling |Estrogen-dependent nuclear events downstream of ESR-membrane signaling|Transcriptional Regulation by NPAS4|TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation|MyD88 dependent cascade initiated on endosome|MyD88 cascade initiated on plasma membrane|NPAS4 regulates expression of target genes","TF_bZIP"]
["FOXD4L4",0,0,0.0202297839289767,0,0.147388770377852,0,0,0,0,0.0207532296918026,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,349334,"forkhead box D4 like 4","protein_coding",null,null,"GO:0000785,GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0009653,GO:0030154","chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|anatomical structure morphogenesis|cell differentiation"]
["FOXP1",6.05554541747288,6.6287150732483,6.6852180681955,6.21935478212662,6.36827047519542,6.10173536243711,6.72792343719569,5.52972895978997,4.87024878942968,4.17212233771348,5.4277526625128,5.1830711026764,4.8378579523757,4.69305027311812,6.39411394737565,6.28635339224521,4.72032143070753,5.10719656752809,4.59129330334992,5.18992088418438,4.40242583850397,5.19759934376871,5.20698700782967,4.88488386003328,4.39709907065615,4.50555246651443,4.87591171003559,4.63990644984564,27086,"forkhead box P1","protein_coding","hsa05206","MicroRNAs in cancer","GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001046,GO:0001227,GO:0002903,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0006974,GO:0010468,GO:0010595,GO:0010629,GO:0021756,GO:0030316,GO:0032496,GO:0032651,GO:0032655,GO:0032680,GO:0032745,GO:0033574,GO:0036035,GO:0042116,GO:0042117,GO:0042118,GO:0042802,GO:0043621,GO:0045655,GO:0045892,GO:0046872,GO:0048661,GO:0050681,GO:0050727,GO:0050861,GO:0060766,GO:0061052,GO:0061470,GO:0071356,GO:1900424,GO:1901256,GO:1901300,GO:1901509,GO:1990837,GO:2000341","negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|core promoter sequence-specific DNA binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|negative regulation of B cell apoptotic process|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|DNA damage response|regulation of gene expression|positive regulation of endothelial cell migration|negative regulation of gene expression|striatum development|osteoclast differentiation|response to lipopolysaccharide|regulation of interleukin-1 beta production|regulation of interleukin-12 production|regulation of tumor necrosis factor production|positive regulation of interleukin-21 production|response to testosterone|osteoclast development|macrophage activation|monocyte activation|endothelial cell activation|identical protein binding|protein self-association|regulation of monocyte differentiation|negative regulation of DNA-templated transcription|metal ion binding|positive regulation of smooth muscle cell proliferation|nuclear androgen receptor binding|regulation of inflammatory response|positive regulation of B cell receptor signaling pathway|negative regulation of androgen receptor signaling pathway|negative regulation of cell growth involved in cardiac muscle cell development|T follicular helper cell differentiation|cellular response to tumor necrosis factor|regulation of defense response to bacterium|regulation of macrophage colony-stimulating factor production|positive regulation of hydrogen peroxide-mediated programmed cell death|regulation of endothelial tube morphogenesis|sequence-specific double-stranded DNA binding|regulation of chemokine (C-X-C motif) ligand 2 production",null,null,"R-HSA-1266738,R-HSA-452723","Developmental Biology|Transcriptional regulation of pluripotent stem cells","Fork_head"]
["FRG1-DT",0.0830060515326962,0.0789525267438723,0.0649408768158837,0.126045421204432,0.081110019462309,0.0974336405582963,0.0516292643208282,0.0474806939543917,0.118281517387556,0.119918200205289,0.149619585929809,0.0765517357936407,0.0394690095077914,0.0791361078879025,0.0321646514982236,0.0393511728208574,0.0798052905063544,0.121604078736997,0.0511439753993803,0.0864720777959658,0.0914029715845394,0.144650570768098,0.0887740170044202,0.114884072974202,0.0548627512733074,0.0525804526431192,0.080323431547171,0.0975441156946229,728339,"FRG1 divergent transcript","non_coding"]
["FRG2C",0.0170447140279754,0.0081061754853217,0,0,0,0,0,0,0.00857233589219671,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,100288801,"FSHD region gene 2 family member C","protein_coding",null,null,"GO:0005634","nucleus"]
["FSD2",0.0190570627325861,3.02107141040091E-3,0.00596381753155411,0.00913841614916323,0,0.00298259217827799,0.00592668914393389,0.00934364815130358,3.19480363226325E-3,3.05906567037175E-3,0.0059740219196466,0.0095864942442822,0.00604103256163793,0.0181685762011992,0,0,3.05370190785184E-3,0.00293880482743315,0.017612943808005,0.0152713963967914,0.00299784022845823,0.00301907341861499,0.00627117209607863,0.0155151904428388,0.018893614502658,0.00301793955387998,0.0122941130646606,0.0059719479810211,123722,"fibronectin type III and SPRY domain containing 2","protein_coding",null,null,"GO:0005515,GO:0005634,GO:0016529,GO:0048471","protein binding|nucleus|sarcoplasmic reticulum|perinuclear region of cytoplasm","WP5408","15q25 copy number variation"]
["FUT3",0,0,0,0.00914811722787784,0,0.0358291009441548,0.00889947111899627,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,2525,"fucosyltransferase 3 (Lewis blood group)","protein_coding","hsa00601","Glycosphingolipid biosynthesis - lacto and neolacto series","GO:0000139,GO:0005515,GO:0006487,GO:0006493,GO:0006672,GO:0008417,GO:0009311,GO:0009312,GO:0009988,GO:0016020,GO:0017060,GO:0017083,GO:0022409,GO:0030334,GO:0032580,GO:0036065,GO:0042127,GO:0043413,GO:0046920,GO:0070062","Golgi membrane|protein binding|protein N-linked glycosylation|protein O-linked glycosylation|ceramide metabolic process|fucosyltransferase activity|oligosaccharide metabolic process|oligosaccharide biosynthetic process|cell-cell recognition|membrane|3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity|4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity|positive regulation of cell-cell adhesion|regulation of cell migration|Golgi cisterna membrane|fucosylation|regulation of cell population proliferation|macromolecule glycosylation|alpha-(1->3)-fucosyltransferase activity|extracellular exosome","WP5303","Lacto series sphingolipid metabolism","R-HSA-1430728,R-HSA-392499,R-HSA-446203,R-HSA-597592,R-HSA-71387,R-HSA-9033658,R-HSA-9037629,R-HSA-948021,R-HSA-975576,R-HSA-975578","Metabolism|Metabolism of proteins|Asparagine N-linked glycosylation|Post-translational protein modification|Metabolism of carbohydrates|Blood group systems biosynthesis|Lewis blood group biosynthesis|Transport to the Golgi and subsequent modification|N-glycan antennae elongation in the medial/trans-Golgi|Reactions specific to the complex N-glycan synthesis pathway"]
["FXR2",21.7851702637686,20.3350400131609,18.537904858717,21.594303755784,19.7443361495954,19.2201115718309,17.2016259444275,19.1235699095754,19.7888083598592,21.4164992998703,21.0902723835991,19.4299334933174,17.4047628917073,16.9924391688241,17.5072661137979,17.0875452742056,17.3703949514767,20.1069504056189,20.2761099494223,18.2675298471504,19.5568698906768,20.0556693440409,17.1323519359262,16.3902461449672,18.8694550916795,21.188599982467,18.697040053423,18.919509074035,9513,"FMR1 autosomal homolog 2","protein_coding",null,null,"GO:0000381,GO:0001934,GO:0003723,GO:0003730,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0005844,GO:0010494,GO:0014069,GO:0016020,GO:0017148,GO:0021542,GO:0030424,GO:0030426,GO:0036464,GO:0042802,GO:0042803,GO:0043025,GO:0043197,GO:0043488,GO:0044326,GO:0045182,GO:0045727,GO:0046982,GO:0051489,GO:0061157,GO:0098793,GO:1902737","regulation of alternative mRNA splicing, via spliceosome|positive regulation of protein phosphorylation|RNA binding|mRNA 3'-UTR binding|protein binding|nucleus|cytoplasm|cytosol|polysome|cytoplasmic stress granule|postsynaptic density|membrane|negative regulation of translation|dentate gyrus development|axon|growth cone|cytoplasmic ribonucleoprotein granule|identical protein binding|protein homodimerization activity|neuronal cell body|dendritic spine|regulation of mRNA stability|dendritic spine neck|translation regulator activity|positive regulation of translation|protein heterodimerization activity|regulation of filopodium assembly|mRNA destabilization|presynapse|dendritic filopodium","WP3888","VEGFA-VEGFR2 signaling"]
["G0S2",0.676982574401082,0.614653532262012,1.15559176690182,0.383656998536274,0.962209271977528,0.664617552274022,1.14839750604034,0.905245911645131,0.495238327434122,1.21513002753681,1.41802207623858,1.08356932374155,1.05349815104016,1.76023637236961,1.54535729040712,0.933647004461987,1.71595039878132,1.65138689621536,1.53576425443704,0.887728364517595,0.92941260343105,1.11149462550667,1.3062829999515,1.50316690968462,1.18981243247304,1.4619436640285,1.16132002443242,1.79360913009441,50486,"G0/G1 switch 2","protein_coding",null,null,"GO:0003674,GO:0005515,GO:0005739,GO:0005811,GO:0097191,GO:0120162,GO:2001238","molecular_function|protein binding|mitochondrion|lipid droplet|extrinsic apoptotic signaling pathway|positive regulation of cold-induced thermogenesis|positive regulation of extrinsic apoptotic signaling pathway","WP2877,WP410","Vitamin D receptor pathway|Exercise-induced circadian regulation","R-HSA-1430728,R-HSA-1989781,R-HSA-400206,R-HSA-556833","Metabolism|PPARA activates gene expression|Regulation of lipid metabolism by PPARalpha|Metabolism of lipids"]
["GADD45G",0.176514038023107,0.0479697531526146,0.213065610155611,0.120919454097206,0.0739208947251212,0.0947175297176627,0.141159431518896,0,0.0760925119560847,0.0728595613034006,0.142286784000114,0.152218104118284,0.239804692940229,0,0.117255048539361,0.0239088744126725,0.048487872950306,0.139990476541207,0.163138038461143,0.0484970406808489,0,0.119845070644459,0.29872836807906,0.123178130297823,0.125000082853179,0.047920024310158,0.146408050860301,0.0474124625958148,10912,"growth arrest and DNA damage inducible gamma","protein_coding","hsa04010,hsa04064,hsa04068,hsa04110,hsa04210,hsa04115,hsa04218,hsa05200,hsa05202,hsa05210,hsa05212,hsa05225,hsa05226,hsa05214,hsa05216,hsa05220,hsa05217,hsa05218,hsa05213,hsa05224,hsa05222,hsa05223,hsa05169","MAPK signaling pathway|NF-kappa B signaling pathway|FoxO signaling pathway|Cell cycle|Apoptosis|p53 signaling pathway|Cellular senescence|Pathways in cancer|Transcriptional misregulation in cancer|Colorectal cancer|Pancreatic cancer|Hepatocellular carcinoma|Gastric cancer|Glioma|Thyroid cancer|Chronic myeloid leukemia|Basal cell carcinoma|Melanoma|Endometrial cancer|Breast cancer|Small cell lung cancer|Non-small cell lung cancer|Epstein-Barr virus infection","GO:0005515,GO:0005634,GO:0005737,GO:0006915,GO:0030154,GO:0043065,GO:0046330,GO:0051726,GO:0120162,GO:1900745","protein binding|nucleus|cytoplasm|apoptotic process|cell differentiation|positive regulation of apoptotic process|positive regulation of JNK cascade|regulation of cell cycle|positive regulation of cold-induced thermogenesis|positive regulation of p38MAPK cascade","WP4216,WP4262,WP5413,WP4685,WP179,WP4658,WP707,WP4263,WP4872,WP4255,WP4155,WP1530","Chromosomal and microsatellite instability in colorectal cancer |Breast cancer pathway|IL-24 Signaling pathway|Melanoma|Cell cycle|Small cell lung cancer|DNA damage response|Pancreatic adenocarcinoma pathway|MAP3K1 role in promoting and blocking gonadal determination|Non-small cell lung cancer|Endometrial cancer|miRNA regulation of DNA damage response"]
["GALNT3",0.118971583112599,0.217618681548739,0.124582639816558,0.162374033879029,0.24592197167224,0.098829566422007,0.0939225799372324,0.103202029241363,0.179503927797268,0.180691547126506,0.146312325334356,0.193353942134972,0.261094432272726,0.130874814309606,0.174475352993776,0.221267683602867,0.105585203565867,0.0592739623130118,0.071894356353623,0.0968047362699207,0.0604646715778221,0.12613536021215,0.153589957367192,0.0983501364231609,0.0362926738604785,0.0608700631323905,0.0929868820733016,0.0602253365480364,2591,"polypeptide N-acetylgalactosaminyltransferase 3","protein_coding","hsa00512,hsa00514","Mucin type O-glycan biosynthesis|Other types of O-glycan biosynthesis","GO:0000139,GO:0004653,GO:0005509,GO:0005794,GO:0005975,GO:0006493,GO:0007283,GO:0008543,GO:0016020,GO:0016266,GO:0018242,GO:0018243,GO:0030145,GO:0030246,GO:0032580,GO:0048471,GO:0070062","Golgi membrane|polypeptide N-acetylgalactosaminyltransferase activity|calcium ion binding|Golgi apparatus|carbohydrate metabolic process|protein O-linked glycosylation|spermatogenesis|fibroblast growth factor receptor signaling pathway|membrane|O-glycan processing|protein O-linked glycosylation via serine|protein O-linked glycosylation via threonine|manganese ion binding|carbohydrate binding|Golgi cisterna membrane|perinuclear region of cytoplasm|extracellular exosome","WP4790","FGF23 signaling in hypophosphatemic rickets and related disorders","R-HSA-162582,R-HSA-1643685,R-HSA-190236,R-HSA-190239,R-HSA-190372,R-HSA-3781865,R-HSA-3906995,R-HSA-392499,R-HSA-5083625,R-HSA-5173105,R-HSA-5654741,R-HSA-5668914,R-HSA-597592,R-HSA-9006934,R-HSA-913709","Signal Transduction|Disease|Signaling by FGFR|FGFR3 ligand binding and activation|FGFR3c ligand binding and activation|Diseases of glycosylation|Diseases associated with O-glycosylation of proteins|Metabolism of proteins|Defective GALNT3 causes HFTC|O-linked glycosylation|Signaling by FGFR3|Diseases of metabolism|Post-translational protein modification|Signaling by Receptor Tyrosine Kinases|O-linked glycosylation of mucins"]
["GARNL3",0.294804814602795,0.354891742629165,0.190281651843232,0.273899507131054,0.256563105393358,0.285487892673444,0.279347889584488,0.325220267368886,0.29190034191766,0.221824080181519,0.233927058931151,0.287329445908853,0.280356764733403,0.23275305962741,0.231328261516855,0.283887241723265,0.146147188488375,0.179006961031759,0.136232448483516,0.0531544803361184,0.117387575275286,0.153246866649434,0.0909491414549202,0.148508369874104,0.16440544048263,0.13568196220218,0.0668618448264109,0.21652393418885,84253,"GTPase activating Rap/RanGAP domain like 3","protein_coding",null,null,"GO:0005096,GO:0005737,GO:0051056,GO:0090630","GTPase activator activity|cytoplasm|regulation of small GTPase mediated signal transduction|activation of GTPase activity"]
["GAS2L3",3.2664753234174,2.58638768339205,1.28781213560516,1.60457411913771,2.98200486260075,1.97119448074139,1.1505225284108,1.34169960741646,2.29262507902569,1.23105694385765,0.791600510137875,1.50551568205809,2.08849487819929,0.88504920043791,1.27568430141035,1.04769842872524,3.18381268258716,2.51916298436831,1.89204366855642,3.05117554760023,3.21711479036522,2.69991755398407,2.8348901152235,3.35369633761957,3.10109110713838,1.93201998295406,2.7486158062007,1.92783873868133,283431,"growth arrest specific 2 like 3","protein_coding",null,null,"GO:0000226,GO:0003779,GO:0005515,GO:0005737,GO:0005874,GO:0005884,GO:0008017,GO:0008093,GO:0015629,GO:0015630,GO:0030036,GO:0051015,GO:0051764","microtubule cytoskeleton organization|actin binding|protein binding|cytoplasm|microtubule|actin filament|microtubule binding|cytoskeletal anchor activity|actin cytoskeleton|microtubule cytoskeleton|actin cytoskeleton organization|actin filament binding|actin crosslink formation"]
["GBP2",10.2998063105307,12.5753095120952,13.1489834619614,12.660680951697,13.9563300207812,14.4089910944874,14.0637680293297,14.0895060105338,17.5301102599337,16.5947809858206,19.5587826317339,17.971771212342,18.4111343538923,18.9162544445005,18.1947423834838,19.1939484622654,16.6354206147864,15.86307609665,11.5913635394414,15.275268786592,16.3808971354722,15.049052232189,11.1316142686897,13.8055143748034,17.0823070662201,15.9769557568829,11.3771077118847,15.534969400979,2634,"guanylate binding protein 2","protein_coding","hsa04621","NOD-like receptor signaling pathway","GO:0000139,GO:0002218,GO:0003924,GO:0004866,GO:0005515,GO:0005525,GO:0005634,GO:0005654,GO:0005737,GO:0005794,GO:0005829,GO:0006955,GO:0030659,GO:0031410,GO:0034504,GO:0042742,GO:0042802,GO:0042803,GO:0042832,GO:0048471,GO:0050830,GO:0051607,GO:0051715,GO:0071222,GO:0071346,GO:0071347,GO:0071356,GO:0140639,GO:0140678,GO:0140973","Golgi membrane|activation of innate immune response|GTPase activity|endopeptidase inhibitor activity|protein binding|GTP binding|nucleus|nucleoplasm|cytoplasm|Golgi apparatus|cytosol|immune response|cytoplasmic vesicle membrane|cytoplasmic vesicle|protein localization to nucleus|defense response to bacterium|identical protein binding|protein homodimerization activity|defense response to protozoan|perinuclear region of cytoplasm|defense response to Gram-positive bacterium|defense response to virus|cytolysis in another organism|cellular response to lipopolysaccharide|cellular response to type II interferon|cellular response to interleukin-1|cellular response to tumor necrosis factor|positive regulation of pyroptosis|molecular function inhibitor activity|positive regulation of AIM2 inflammasome complex assembly",null,null,"R-HSA-1280215,R-HSA-168256,R-HSA-877300,R-HSA-909733,R-HSA-913531","Cytokine Signaling in Immune system|Immune System|Interferon gamma signaling|Interferon alpha/beta signaling|Interferon Signaling"]
["GCN1",17.5816254650324,18.4036170714562,19.4390209938094,16.5848420739129,18.6941239502812,17.2302790299413,17.1422635810357,17.1065094716475,18.9746991065701,22.0085813437128,18.1143620303391,18.5102106768996,18.2496316038957,17.6589362323807,17.5723594359404,18.3982961159913,14.7541375314319,17.4398956321254,15.1989337347053,17.6175374541056,15.1729872927053,15.9268562902921,14.2117185012203,14.1521753325713,15.6668143239944,14.5636466740347,13.3835667774541,15.1859097409656,10985,"GCN1 activator of EIF2AK4","protein_coding",null,null,"GO:0003723,GO:0005737,GO:0005829,GO:0005840,GO:0005844,GO:0006417,GO:0008135,GO:0016020,GO:0019887,GO:0022626,GO:0034198,GO:0043539,GO:0045296,GO:0060090,GO:0072344,GO:0140469,GO:0170011,GO:1990253","RNA binding|cytoplasm|cytosol|ribosome|polysome|regulation of translation|translation factor activity, RNA binding|membrane|protein kinase regulator activity|cytosolic ribosome|cellular response to amino acid starvation|protein serine/threonine kinase activator activity|cadherin binding|molecular adaptor activity|rescue of stalled ribosome|GCN2-mediated signaling|stalled ribosome sensor activity|cellular response to leucine starvation",null,null,"R-HSA-2262752,R-HSA-8953897,R-HSA-9633012,R-HSA-9711097","Cellular responses to stress|Cellular responses to stimuli|Response of EIF2AK4 (GCN2) to amino acid deficiency|Cellular response to starvation"]
["GDA",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,3.23817547373665E-3,9615,"guanine deaminase","protein_coding","hsa00230","Purine metabolism","GO:0000255,GO:0005829,GO:0006139,GO:0006147,GO:0006161,GO:0007399,GO:0008270,GO:0008892,GO:0043605,GO:0046038,GO:0046055,GO:0046098","allantoin metabolic process|cytosol|nucleobase-containing compound metabolic process|guanine catabolic process|deoxyguanosine catabolic process|nervous system development|zinc ion binding|guanine deaminase activity|amide catabolic process|GMP catabolic process|dGMP catabolic process|guanine metabolic process",null,null,"R-HSA-1430728,R-HSA-15869,R-HSA-74259,R-HSA-8956319","Metabolism|Metabolism of nucleotides|Purine catabolism|Nucleotide catabolism"]
["GEMIN6",3.31768802895299,2.88577878165998,2.94399868518477,4.08896395724316,2.70158757132152,3.27261847567199,3.02070388532149,3.06068407179385,2.73704388979886,2.44557066942276,3.41431315681353,2.79619795598445,2.63616230993072,2.22659211410187,2.65915461415444,2.4351366050588,4.81261442570951,4.1603053712612,5.35253796952032,4.25381222464225,5.52116240086794,4.46066264154969,5.86104251886723,5.65093386905568,5.05647433671279,5.24017429670305,6.48429599939088,5.52666793415118,79833,"gem nuclear organelle associated protein 6","protein_coding",null,null,"GO:0000245,GO:0000387,GO:0000398,GO:0003723,GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0016604,GO:0032797,GO:0034719,GO:0097504","spliceosomal complex assembly|spliceosomal snRNP assembly|mRNA splicing, via spliceosome|RNA binding|protein binding|nucleoplasm|cytoplasm|cytosol|nuclear body|SMN complex|SMN-Sm protein complex|Gemini of coiled bodies",null,null,"R-HSA-1643685,R-HSA-191859,R-HSA-194441,R-HSA-5663205,R-HSA-8953854,R-HSA-9679506,R-HSA-9694516,R-HSA-9705683,R-HSA-9754678,R-HSA-9824446","Disease|snRNP Assembly|Metabolism of non-coding RNA|Infectious disease|Metabolism of RNA|SARS-CoV Infections|SARS-CoV-2 Infection|SARS-CoV-2-host interactions|SARS-CoV-2 modulates host translation machinery|Viral Infection Pathways"]
["GFRA4",0,0,0,0,0,0,0,0,0,0,0,0.017373601676537,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,64096,"GDNF family receptor alpha 4","protein_coding",null,null,"GO:0001503,GO:0005576,GO:0005886,GO:0007399,GO:0009897,GO:0016167,GO:0030279,GO:0035860,GO:0043235","ossification|extracellular region|plasma membrane|nervous system development|external side of plasma membrane|glial cell-derived neurotrophic factor receptor activity|negative regulation of ossification|glial cell-derived neurotrophic factor receptor signaling pathway|receptor complex",null,null,"R-HSA-1266738,R-HSA-1266738,R-HSA-162582,R-HSA-375165,R-HSA-419037,R-HSA-422475,R-HSA-422475,R-HSA-5673001,R-HSA-5683057,R-HSA-5684996,R-HSA-8853659,R-HSA-9675108,R-HSA-9675108","Developmental Biology|Developmental Biology|Signal Transduction|NCAM signaling for neurite out-growth|NCAM1 interactions|Axon guidance|Axon guidance|RAF/MAP kinase cascade|MAPK family signaling cascades|MAPK1/MAPK3 signaling|RET signaling|Nervous system development|Nervous system development"]
["GINS4",7.03848902770723,4.81165711895768,2.39448520900268,4.50021374920662,5.23229584513656,3.55285429214672,1.75510317226076,2.95697890888034,4.10328771281848,4.22752401583619,2.46484147150015,3.67178765510834,3.14911322200626,1.22922099835262,1.24493846883584,1.01539602340991,6.34032800158246,6.53854194462532,5.1376786758907,6.00954514698157,5.66574878623212,6.14788297524178,5.25139772248583,5.85768350843729,5.86050440722798,5.87779302889136,4.84748025478438,5.19291626394433,84296,"GINS complex subunit 4","protein_coding",null,null,"GO:0000727,GO:0000811,GO:0001833,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006268,GO:0071162","double-strand break repair via break-induced replication|GINS complex|inner cell mass cell proliferation|protein binding|nucleus|nucleoplasm|cytoplasm|DNA unwinding involved in DNA replication|CMG complex",null,null,"R-HSA-1640170,R-HSA-1640170,R-HSA-176974,R-HSA-176974,R-HSA-69190,R-HSA-69190,R-HSA-69239,R-HSA-69239,R-HSA-69242,R-HSA-69242,R-HSA-69278,R-HSA-69278,R-HSA-69306,R-HSA-69306","Cell Cycle|Cell Cycle|Unwinding of DNA|Unwinding of DNA|DNA strand elongation|DNA strand elongation|Synthesis of DNA|Synthesis of DNA|S Phase|S Phase|Cell Cycle, Mitotic|Cell Cycle, Mitotic|DNA Replication|DNA Replication"]
["GLCCI1-DT",0,0.0219143872308312,0.0648909222952561,0.287250880955364,0.0225132297610126,0,0.0429912912517666,0.0225924620684084,0.231746140401864,0.0221899917473889,0.0866692718496422,0.0927186058703396,0.0219103604062483,0.0439306855326433,0.0214266063057397,0.0436898918754648,0.0664532515177912,0.085270552377522,0.0212935974499343,0.155086904023415,0.21745871811047,0,0.0227450587946236,0.0900358436159815,0.0228418954820597,0.0656750076763576,0.245243913114856,0.0433195918930992,100505921,"GLCCI1 divergent transcript","non_coding"]
["GLI4",4.60375810759208,5.56970156361126,6.21786275656116,7.24259524566109,4.4788679342527,4.85407828701394,5.01114219602052,5.92024045347663,6.31651446502071,9.6653620233627,10.3871661593731,6.96795949846929,6.14474826674111,8.00821845035511,5.80251758630269,6.49015798298337,7.31881765592573,9.21065680091357,7.89394330632733,8.19396554227087,7.33739921894092,6.98631228597596,5.30240988618934,6.45071412154276,6.16577187708991,8.99821397309555,7.346796204119,9.35849205987212,2738,"GLI family zinc finger 4","protein_coding",null,null,"GO:0000978,GO:0000981,GO:0003674,GO:0005515,GO:0005634,GO:0006355,GO:0006357,GO:0008150,GO:0046872","RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|molecular_function|protein binding|nucleus|regulation of DNA-templated transcription|regulation of transcription by RNA polymerase II|biological_process|metal ion binding","WP4204","Tumor suppressor activity of SMARCB1",null,null,"zf-C2H2"]
["GLT1D1",0,0.00558845533131485,0,0.0112696509529131,0.040188176055513,0.0110345509228619,0.00548167074592054,0.0288068664124213,0,0,0,0,0.01117485687677,0.0056014496592407,0.0327843888984945,0.00557074689344963,0,0,0,0,0.00554548169549368,0,0,0.0114801587871292,0,0,0,0,144423,"glycosyltransferase 1 domain containing 1","protein_coding",null,null,"GO:0005576,GO:0005829,GO:0016757","extracellular region|cytosol|glycosyltransferase activity"]
["GNA15-DT",0.0232481373309556,0.0110564178784271,0.0109130917184777,0.0111481583811913,0,0.0218311856981848,0.0108451510919721,0.0113985254937636,0,0.0111954680226153,0,0,0,0.0110821263633447,0,0,0,0.0107553413412786,0.0537160608374798,0,0,0,0,0,0.0460974863544801,0,0,0,100996351,"GNA15 divergent transcript","non_coding"]
["GNAO1",0.0330954146534599,0.00944376908289964,0.0248569278773725,0.0253923430678775,0.0129357784262172,0.0186469685576761,0.0370532675982076,0.00973597812892737,0.0632500515792935,0.0318751262669675,0.0248994593159193,0.0133186947659051,0.0220314121212,0.00946572782195077,0.0461678257416492,0.0125517921410175,0.00954577093625731,0.0153110107860191,0.0122349952198517,0.0286427273413411,0.0187422983564825,0.0220208879958868,0.00653449202939464,0.00646666280114784,3.28115625709145E-3,0.0157232983387228,0.016012912458529,0.00933405571177276,2775,"G protein subunit alpha o1","protein_coding","hsa04015,hsa04915,hsa04921,hsa04926,hsa04916,hsa04724,hsa04727,hsa04725,hsa04728,hsa04726,hsa04730,hsa04723,hsa04713,hsa05170,hsa05163,hsa05145,hsa05142,hsa05032,hsa05034","Rap1 signaling pathway|Estrogen signaling pathway|Oxytocin signaling pathway|Relaxin signaling pathway|Melanogenesis|Glutamatergic synapse|GABAergic synapse|Cholinergic synapse|Dopaminergic synapse|Serotonergic synapse|Long-term depression|Retrograde endocannabinoid signaling|Circadian entrainment|Human immunodeficiency virus 1 infection|Human cytomegalovirus infection|Toxoplasmosis|Chagas disease|Morphine addiction|Alcoholism","GO:0003924,GO:0005515,GO:0005525,GO:0005834,GO:0005886,GO:0006936,GO:0007188,GO:0007212,GO:0031683,GO:0031821,GO:0031852,GO:0046872,GO:0051430","GTPase activity|protein binding|GTP binding|heterotrimeric G-protein complex|plasma membrane|muscle contraction|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|dopamine receptor signaling pathway|G-protein beta/gamma-subunit complex binding|G protein-coupled serotonin receptor binding|mu-type opioid receptor binding|metal ion binding|corticotropin-releasing hormone receptor 1 binding","WP35,WP4900,WP2032,WP2355,WP4312,WP536,WP4673,WP722","G protein signaling pathways|Purinergic signaling|Thyroid stimulating hormone (TSH) signaling pathway|Corticotropin-releasing hormone signaling pathway|Rett syndrome causing genes|Calcium regulation in cardiac cells|Male infertility|Serotonin HTR1 group and FOS pathway","R-HSA-162582,R-HSA-162582,R-HSA-195721,R-HSA-195721,R-HSA-3858494,R-HSA-3858494,R-HSA-4086398,R-HSA-4086398","Signal Transduction|Signal Transduction|Signaling by WNT|Signaling by WNT|Beta-catenin independent WNT signaling|Beta-catenin independent WNT signaling|Ca2+ pathway|Ca2+ pathway"]
["GNG8",0.0215534770004609,0.0205009326173287,0.0472154098790109,0.0137806925831464,0.0421223008854768,0.0404796265731002,0.00670306646649346,0.00704509078359217,0.0505863776623474,0.0207587609363899,0.0405395981066423,0.0867383546388305,0.00683238850621283,0.0410972031502073,0.0133630753612556,0.0136239801424024,0.0069074541822864,0,0.0132801220769846,0.027635040771763,0.0203432862624667,0.00682912476113685,0.00709267558361132,0.0280762092299302,0.00712287252505593,0,0.0486661089457906,0.0472797784654161,94235,"G protein subunit gamma 8","protein_coding","hsa04014,hsa04371,hsa04151,hsa04062,hsa04926,hsa04724,hsa04727,hsa04725,hsa04728,hsa04726,hsa04723,hsa04713,hsa05200,hsa05170,hsa05163,hsa05167,hsa05032,hsa05034","Ras signaling pathway|Apelin signaling pathway|PI3K-Akt signaling pathway|Chemokine signaling pathway|Relaxin signaling pathway|Glutamatergic synapse|GABAergic synapse|Cholinergic synapse|Dopaminergic synapse|Serotonergic synapse|Retrograde endocannabinoid signaling|Circadian entrainment|Pathways in cancer|Human immunodeficiency virus 1 infection|Human cytomegalovirus infection|Kaposi sarcoma-associated herpesvirus infection|Morphine addiction|Alcoholism","GO:0003924,GO:0005515,GO:0005834,GO:0005886,GO:0007186,GO:0031681,GO:0035176,GO:0043584,GO:0071444","GTPase activity|protein binding|heterotrimeric G-protein complex|plasma membrane|G protein-coupled receptor signaling pathway|G-protein beta-subunit binding|social behavior|nose development|cellular response to pheromone","WP35,WP289,WP4223,WP3929,WP3932,WP536,WP4172","G protein signaling pathways|Myometrial relaxation and contraction pathways|Ras signaling|Chemokine signaling pathway|Focal adhesion: PI3K-Akt-mTOR-signaling pathway|Calcium regulation in cardiac cells|PI3K-Akt signaling pathway","R-HSA-109582,R-HSA-109582,R-HSA-111885,R-HSA-112314,R-HSA-112315,R-HSA-112316,R-HSA-1296041,R-HSA-1296059,R-HSA-1296065,R-HSA-1296071,R-HSA-1430728,R-HSA-1430728,R-HSA-162582,R-HSA-162582,R-HSA-163359,R-HSA-163685,R-HSA-163685,R-HSA-1643685,R-HSA-195721,R-HSA-195721,R-HSA-202040,R-HSA-372790,R-HSA-373080,R-HSA-381676,R-HSA-381676,R-HSA-382551,R-HSA-3858494,R-HSA-3858494,R-HSA-388396,R-HSA-390466,R-HSA-391251,R-HSA-392170,R-HSA-392451,R-HSA-392499,R-HSA-392518,R-HSA-392518,R-HSA-392851,R-HSA-392851,R-HSA-397795,R-HSA-400042,R-HSA-400042,R-HSA-4086398,R-HSA-4086398,R-HSA-416476,R-HSA-416482,R-HSA-418217,R-HSA-418346,R-HSA-418346,R-HSA-418555,R-HSA-418592,R-HSA-418592,R-HSA-418594,R-HSA-418597,R-HSA-420092,R-HSA-422356,R-HSA-422356,R-HSA-428930,R-HSA-432040,R-HSA-445717,R-HSA-451326,R-HSA-456926,R-HSA-456926,R-HSA-500657,R-HSA-500792,R-HSA-5663205,R-HSA-6814122,R-HSA-76002,R-HSA-76002,R-HSA-8939211,R-HSA-8964315,R-HSA-8964616,R-HSA-9006931,R-HSA-9009391,R-HSA-9634597,R-HSA-9658195,R-HSA-9660821,R-HSA-9662851,R-HSA-9664433,R-HSA-977443,R-HSA-977444,R-HSA-9824443,R-HSA-991365,R-HSA-997272","Hemostasis|Hemostasis|Opioid Signalling|Neurotransmitter receptors and postsynaptic signal transmission|Transmission across Chemical Synapses|Neuronal System|Activation of G protein gated Potassium channels|G protein gated Potassium channels|Inwardly rectifying K+ channels|Potassium Channels|Metabolism|Metabolism|Signal Transduction|Signal Transduction|Glucagon signaling in metabolic regulation|Integration of energy metabolism|Integration of energy metabolism|Disease|Signaling by WNT|Signaling by WNT|G-protein activation|Signaling by GPCR|Class B/2 (Secretin family receptors)|Glucagon-like Peptide-1 (GLP1) regulates insulin secretion|Glucagon-like Peptide-1 (GLP1) regulates insulin secretion|Transport of small molecules|Beta-catenin independent WNT signaling|Beta-catenin independent WNT signaling|GPCR downstream signalling|Chaperonin-mediated protein folding|Protein folding|ADP signalling through P2Y purinoceptor 12|G beta:gamma signalling through PI3Kgamma|Metabolism of proteins|Signal amplification|Signal amplification|Prostacyclin signalling through prostacyclin receptor|Prostacyclin signalling through prostacyclin receptor|G-protein beta:gamma signalling|Adrenaline,noradrenaline inhibits insulin secretion|Adrenaline,noradrenaline inhibits insulin secretion|Ca2+ pathway|Ca2+ pathway|G alpha (q) signalling events|G alpha (12/13) signalling events|G beta:gamma signalling through PLC beta|Platelet homeostasis|Platelet homeostasis|G alpha (s) signalling events|ADP signalling through P2Y purinoceptor 1|ADP signalling through P2Y purinoceptor 1|G alpha (i) signalling events|G alpha (z) signalling events|Glucagon-type ligand receptors|Regulation of insulin secretion|Regulation of insulin secretion|Thromboxane signalling through TP receptor|Vasopressin regulates renal water homeostasis via Aquaporins|Aquaporin-mediated transport|Activation of kainate receptors upon glutamate binding|Thrombin signalling through proteinase activated receptors (PARs)|Thrombin signalling through proteinase activated receptors (PARs)|Presynaptic function of Kainate receptors|GPCR ligand binding|Infectious disease|Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding|Platelet activation, signaling and aggregation|Platelet activation, signaling and aggregation|ESR-mediated signaling|G beta:gamma signalling through BTK|G beta:gamma signalling through CDC42|Signaling by Nuclear Receptors|Extra-nuclear estrogen signaling|GPER1 signaling|Leishmania infection|ADORA2B mediated anti-inflammatory cytokines production|Anti-inflammatory response favouring Leishmania parasite infection|Leishmania parasite growth and survival|GABA receptor activation|GABA B receptor activation|Parasitic Infection Pathways|Activation of GABAB receptors|Inhibition  of voltage gated Ca2+ channels via Gbeta/gamma subunits"]
["GOLGA7B",0.00393923940307512,0.00374687024113291,0.00369829894712112,0,0.0115477767735137,0,0.003675274789169,0.00386280587754461,7.92468169721414E-3,0,0,0,0.00374618174416346,7.51116499681319E-3,0,0.0149399893304965,0.00378734006896662,0,0,0.00378805615138298,0,0,0,0,0,0.0149719438806251,0.00381192962077214,0,401647,"golgin A7 family member B","protein_coding",null,null,"GO:0000139,GO:0002178,GO:0005515,GO:0005886,GO:0006612,GO:0018230,GO:0019899","Golgi membrane|palmitoyltransferase complex|protein binding|plasma membrane|protein targeting to membrane|peptidyl-L-cysteine S-palmitoylation|enzyme binding"]
["GOSR2",5.24997282847966,5.33068611902677,5.33271704882839,5.4358628492333,5.44291878063805,5.43492603561188,5.41809549263809,5.47166119825427,5.58560939579158,5.62371127326859,5.01544679653245,5.52534879968864,5.41338275290582,5.74154024428084,5.61890360156974,5.46442538306033,6.7018426510299,5.9792988568505,5.98610924775784,6.16958737331341,6.777637547883,6.05200763898459,6.0418663386919,6.40657396530428,5.98277892246716,6.34699614035717,6.28178904279361,6.5141409162125,9570,"golgi SNAP receptor complex member 2","protein_coding","hsa04130","SNARE interactions in vesicular transport","GO:0000139,GO:0000149,GO:0005484,GO:0005515,GO:0005654,GO:0005789,GO:0005794,GO:0005829,GO:0006888,GO:0006891,GO:0006906,GO:0012507,GO:0015031,GO:0016020,GO:0031201,GO:0031902,GO:0033116","Golgi membrane|SNARE binding|SNAP receptor activity|protein binding|nucleoplasm|endoplasmic reticulum membrane|Golgi apparatus|cytosol|endoplasmic reticulum to Golgi vesicle-mediated transport|intra-Golgi vesicle-mediated transport|vesicle fusion|ER to Golgi transport vesicle membrane|protein transport|membrane|SNARE complex|late endosome membrane|endoplasmic reticulum-Golgi intermediate compartment membrane",null,null,"R-HSA-199977,R-HSA-199991,R-HSA-204005,R-HSA-2262752,R-HSA-381038,R-HSA-381070,R-HSA-381119,R-HSA-392499,R-HSA-446203,R-HSA-5653656,R-HSA-5694530,R-HSA-597592,R-HSA-6807878,R-HSA-6811438,R-HSA-6811442,R-HSA-8953897,R-HSA-948021","ER to Golgi Anterograde Transport|Membrane Trafficking|COPII-mediated vesicle transport|Cellular responses to stress|XBP1(S) activates chaperone genes|IRE1alpha activates chaperones|Unfolded Protein Response (UPR)|Metabolism of proteins|Asparagine N-linked glycosylation|Vesicle-mediated transport|Cargo concentration in the ER|Post-translational protein modification|COPI-mediated anterograde transport|Intra-Golgi traffic|Intra-Golgi and retrograde Golgi-to-ER traffic|Cellular responses to stimuli|Transport to the Golgi and subsequent modification"]
["GPC3",0.381755998610838,0.45389161593362,0.557520748594962,0.467827949313614,0.393760108251229,0.368446346668245,0.563943590397387,0.478334503745767,12.9384909488485,12.2662119211953,15.7868828762235,15.0430649197776,12.6864606874668,16.4084221213201,17.3077584806808,16.0168484217958,2.93628214416928,3.59112469896759,4.29272893359297,3.42631020061173,2.21197091824643,3.11466117862695,2.69048455112328,3.0769625588235,2.57577865457608,2.86159081441123,3.18110175548095,3.88802710086962,2719,"glypican 3","protein_coding","hsa05205","Proteoglycans in cancer","GO:0001658,GO:0005515,GO:0005788,GO:0005796,GO:0005886,GO:0007224,GO:0009617,GO:0009653,GO:0009948,GO:0009986,GO:0010171,GO:0016477,GO:0030282,GO:0030316,GO:0030324,GO:0030513,GO:0035116,GO:0042074,GO:0043202,GO:0045732,GO:0045807,GO:0045879,GO:0045880,GO:0045926,GO:0046326,GO:0050673,GO:0050680,GO:0060070,GO:0060071,GO:0060422,GO:0060828,GO:0060976,GO:0062023,GO:0072111,GO:0072138,GO:0072180,GO:0072203,GO:0090090,GO:0090263,GO:0098552,GO:1905475,GO:2000050,GO:2000096","branching involved in ureteric bud morphogenesis|protein binding|endoplasmic reticulum lumen|Golgi lumen|plasma membrane|smoothened signaling pathway|response to bacterium|anatomical structure morphogenesis|anterior/posterior axis specification|cell surface|body morphogenesis|cell migration|bone mineralization|osteoclast differentiation|lung development|positive regulation of BMP signaling pathway|embryonic hindlimb morphogenesis|cell migration involved in gastrulation|lysosomal lumen|positive regulation of protein catabolic process|positive regulation of endocytosis|negative regulation of smoothened signaling pathway|positive regulation of smoothened signaling pathway|negative regulation of growth|positive regulation of glucose import|epithelial cell proliferation|negative regulation of epithelial cell proliferation|canonical Wnt signaling pathway|Wnt signaling pathway, planar cell polarity pathway|peptidyl-dipeptidase inhibitor activity|regulation of canonical Wnt signaling pathway|coronary vasculature development|collagen-containing extracellular matrix|cell proliferation involved in kidney development|mesenchymal cell proliferation involved in ureteric bud development|mesonephric duct morphogenesis|cell proliferation involved in metanephros development|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|side of membrane|regulation of protein localization to membrane|regulation of non-canonical Wnt signaling pathway|positive regulation of Wnt signaling pathway, planar cell polarity pathway","WP5053","Development of ureteric collection system","R-HSA-1430728,R-HSA-1430728,R-HSA-1630316,R-HSA-1630316,R-HSA-1638091,R-HSA-1638091,R-HSA-1643685,R-HSA-1643685,R-HSA-1793185,R-HSA-196854,R-HSA-1971475,R-HSA-2022928,R-HSA-2022928,R-HSA-2024096,R-HSA-2187338,R-HSA-3560782,R-HSA-3560783,R-HSA-3560801,R-HSA-3656237,R-HSA-3656253,R-HSA-3781865,R-HSA-381426,R-HSA-392499,R-HSA-4420332,R-HSA-5663205,R-HSA-5663205,R-HSA-5668914,R-HSA-597592,R-HSA-6806667,R-HSA-71387,R-HSA-71387,R-HSA-8957275,R-HSA-9679506,R-HSA-9679506,R-HSA-9694516,R-HSA-9694516,R-HSA-9694614,R-HSA-9694614,R-HSA-9709957,R-HSA-975634,R-HSA-9772572,R-HSA-9772572,R-HSA-9824446,R-HSA-9824446","Metabolism|Metabolism|Glycosaminoglycan metabolism|Glycosaminoglycan metabolism|Heparan sulfate/heparin (HS-GAG) metabolism|Heparan sulfate/heparin (HS-GAG) metabolism|Disease|Disease|Chondroitin sulfate/dermatan sulfate metabolism|Metabolism of vitamins and cofactors|A tetrasaccharide linker sequence is required for GAG synthesis|HS-GAG biosynthesis|HS-GAG biosynthesis|HS-GAG degradation|Visual phototransduction|Diseases associated with glycosaminoglycan metabolism|Defective B4GALT7 causes EDS, progeroid type|Defective B3GAT3 causes JDSSDHD|Defective EXT2 causes exostoses 2|Defective EXT1 causes exostoses 1, TRPS2 and CHDS|Diseases of glycosylation|Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)|Metabolism of proteins|Defective B3GALT6 causes EDSP2 and SEMDJL1|Infectious disease|Infectious disease|Diseases of metabolism|Post-translational protein modification|Metabolism of fat-soluble vitamins|Metabolism of carbohydrates|Metabolism of carbohydrates|Post-translational protein phosphorylation|SARS-CoV Infections|SARS-CoV Infections|SARS-CoV-2 Infection|SARS-CoV-2 Infection|Attachment and Entry|Attachment and Entry|Sensory Perception|Retinoid metabolism and transport|Early SARS-CoV-2 Infection Events|Early SARS-CoV-2 Infection Events|Viral Infection Pathways|Viral Infection Pathways"]
["GPER1",3.98440407674213,3.83661735570428,2.78936234596177,3.82127540540986,3.32620644958144,3.0117236132689,2.44156015755014,3.35720688166903,1.60310815517406,2.5109514384226,1.79490796755764,1.81131210792868,1.31917961905795,1.85711361505331,0.832587873493471,1.19397777504919,2.13766043386062,2.5669859535985,2.03672482470028,2.27997154992088,2.4421248959771,2.66515317137914,1.8356258581223,1.76851427131829,2.68225542750099,2.38371515088093,1.38993248965758,2.59893836253544,2852,"G protein-coupled estrogen receptor 1","protein_coding","hsa04929,hsa04915,hsa01522","GnRH secretion|Estrogen signaling pathway|Endocrine resistance","GO:0000139,GO:0001934,GO:0001956,GO:0002695,GO:0003682,GO:0004930,GO:0005496,GO:0005515,GO:0005634,GO:0005635,GO:0005654,GO:0005730,GO:0005737,GO:0005769,GO:0005783,GO:0005789,GO:0005794,GO:0005802,GO:0005829,GO:0005886,GO:0006954,GO:0007049,GO:0007186,GO:0007189,GO:0007204,GO:0007399,GO:0008284,GO:0008285,GO:0010628,GO:0010629,GO:0010948,GO:0014069,GO:0019228,GO:0030154,GO:0030263,GO:0030264,GO:0030284,GO:0030335,GO:0030424,GO:0030425,GO:0030518,GO:0030659,GO:0031966,GO:0032024,GO:0032591,GO:0032962,GO:0038054,GO:0042311,GO:0042734,GO:0043065,GO:0043198,GO:0043231,GO:0043280,GO:0043401,GO:0043410,GO:0043679,GO:0044327,GO:0045087,GO:0045095,GO:0045599,GO:0045742,GO:0045745,GO:0045944,GO:0048471,GO:0048786,GO:0050728,GO:0050769,GO:0051055,GO:0051281,GO:0051480,GO:0051726,GO:0051897,GO:0051898,GO:0055037,GO:0070373,GO:0070374,GO:0070474,GO:0071333,GO:0071356,GO:0071375,GO:0071389,GO:0071392,GO:0090200,GO:0098686,GO:1903078,GO:1904706,GO:1990239,GO:2000353,GO:2000724,GO:2001238","Golgi membrane|positive regulation of protein phosphorylation|positive regulation of neurotransmitter secretion|negative regulation of leukocyte activation|chromatin binding|G protein-coupled receptor activity|steroid binding|protein binding|nucleus|nuclear envelope|nucleoplasm|nucleolus|cytoplasm|early endosome|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|trans-Golgi network|cytosol|plasma membrane|inflammatory response|cell cycle|G protein-coupled receptor signaling pathway|adenylate cyclase-activating G protein-coupled receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|nervous system development|positive regulation of cell population proliferation|negative regulation of cell population proliferation|positive regulation of gene expression|negative regulation of gene expression|negative regulation of cell cycle process|postsynaptic density|neuronal action potential|cell differentiation|apoptotic chromosome condensation|nuclear fragmentation involved in apoptotic nuclear change|nuclear estrogen receptor activity|positive regulation of cell migration|axon|dendrite|intracellular steroid hormone receptor signaling pathway|cytoplasmic vesicle membrane|mitochondrial membrane|positive regulation of insulin secretion|dendritic spine membrane|positive regulation of inositol trisphosphate biosynthetic process|G protein-coupled estrogen receptor activity|vasodilation|presynaptic membrane|positive regulation of apoptotic process|dendritic shaft|intracellular membrane-bounded organelle|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|steroid hormone mediated signaling pathway|positive regulation of MAPK cascade|axon terminus|dendritic spine head|innate immune response|keratin filament|negative regulation of fat cell differentiation|positive regulation of epidermal growth factor receptor signaling pathway|positive regulation of G protein-coupled receptor signaling pathway|positive regulation of transcription by RNA polymerase II|perinuclear region of cytoplasm|presynaptic active zone|negative regulation of inflammatory response|positive regulation of neurogenesis|negative regulation of lipid biosynthetic process|positive regulation of release of sequestered calcium ion into cytosol|regulation of cytosolic calcium ion concentration|regulation of cell cycle|positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction|negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction|recycling endosome|negative regulation of ERK1 and ERK2 cascade|positive regulation of ERK1 and ERK2 cascade|positive regulation of uterine smooth muscle contraction|cellular response to glucose stimulus|cellular response to tumor necrosis factor|cellular response to peptide hormone stimulus|cellular response to mineralocorticoid stimulus|cellular response to estradiol stimulus|positive regulation of release of cytochrome c from mitochondria|hippocampal mossy fiber to CA3 synapse|positive regulation of protein localization to plasma membrane|negative regulation of vascular associated smooth muscle cell proliferation|steroid hormone binding|positive regulation of endothelial cell apoptotic process|positive regulation of cardiac vascular smooth muscle cell differentiation|positive regulation of extrinsic apoptotic signaling pathway","WP712,WP455","Estrogen signaling pathway|GPCRs, class A rhodopsin-like","R-HSA-162582,R-HSA-372790,R-HSA-373076,R-HSA-375276,R-HSA-388396,R-HSA-418555,R-HSA-418594,R-HSA-500792,R-HSA-9634597","Signal Transduction|Signaling by GPCR|Class A/1 (Rhodopsin-like receptors)|Peptide ligand-binding receptors|GPCR downstream signalling|G alpha (s) signalling events|G alpha (i) signalling events|GPCR ligand binding|GPER1 signaling"]
["GPR155-DT",0.154145619643992,0.476508691609639,0.217076137485202,0.351107224041224,0.150624610838512,0.361876480586781,0.3235870599579,0.453464142159333,0.09690599866697,0.111346491827498,0.144965043694183,0.232624951111431,0.238210565960712,0.257178209086739,0.179193204987244,0.09134591403555,0.185252095010283,0.196110080253522,0.267121254643564,0.203815833225912,0.0727453038425304,0.183151366002755,0.152175661413636,0.131771543819672,0.0573088299800068,0.329548644666211,0.205100341918786,0.199257736834948,105373748,null,"non_coding"]
["GPR199P",0.814257693910364,1.19571028579034,1.23385601057434,1.76734643767449,1.06087779032816,1.27438244971876,1.0529107181772,0.784450511246485,0.991460832784449,1.70605405549082,1.26283605167245,1.29349088475712,0.801522087357352,1.30744424987453,1.24880665686553,1.12419856916438,0.947671965206021,0.859144873915017,0.660135374044068,0.961588117156313,0.728089126137759,1.00481867073668,0.634619684969229,0.795507473602253,0.906412895440716,0.732970673907838,1.18882509696087,1.10124049979436,653160,"G protein-coupled receptor 199%2C pseudogene","non_coding",null,null,"GO:0004930,GO:0007200,GO:0016020,GO:0035025","G protein-coupled receptor activity|phospholipase C-activating G protein-coupled receptor signaling pathway|membrane|positive regulation of Rho protein signal transduction"]
["GPR78",0.00620681907327725,5.90371472716383E-3,0,0,0.01213008465134,0,0,0,0,0,0.00583715450518543,0,0.00590262990451544,0,0.00577230701766417,5.88500730995784E-3,0,0,0,0,0.00585831683604076,0,0,0,0,0.00589759451848479,0.0060062248203877,0,27201,"G protein-coupled receptor 78","protein_coding",null,null,"GO:0004930,GO:0005515,GO:0005886,GO:0007189","G protein-coupled receptor activity|protein binding|plasma membrane|adenylate cyclase-activating G protein-coupled receptor signaling pathway"]
["GPT2",6.4465705168429,7.44895061444091,8.87666433948569,7.64815011649092,7.5650135141805,9.03564544399405,8.96619744585393,8.51644769755426,8.11747818275655,7.74384523781388,7.33690123005726,8.4615480145832,9.20162361286059,11.2961493152444,10.2308249431199,10.5154681523912,8.95264796798587,8.16844120630179,6.04632548317089,7.33567139409251,9.48184535913436,8.06814212125396,5.66294547318666,6.91044039976625,8.61639189362231,8.63227879905499,5.348702801089,7.44097445247918,84706,"glutamic--pyruvic transaminase 2","protein_coding","hsa00250,hsa00220","Alanine, aspartate and glutamate metabolism|Arginine biosynthesis","GO:0004021,GO:0005615,GO:0005759,GO:0006103,GO:0009058,GO:0030170,GO:0032869,GO:0033574,GO:0042594,GO:0042851,GO:0042853,GO:0045722","L-alanine:2-oxoglutarate aminotransferase activity|extracellular space|mitochondrial matrix|2-oxoglutarate metabolic process|biosynthetic process|pyridoxal phosphate binding|cellular response to insulin stimulus|response to testosterone|response to starvation|L-alanine metabolic process|L-alanine catabolic process|positive regulation of gluconeogenesis","WP4661,WP3925","Amino acid metabolism pathway excerpt: histidine catabolism extension|Amino acid metabolism","R-HSA-1430728,R-HSA-71291,R-HSA-8964540","Metabolism|Metabolism of amino acids and derivatives|Alanine metabolism"]
["GRIA1",0.0214927565262662,0.0245318128465053,0.0322850705726676,0.0288579261683749,0.0126010901708108,0.0161462349335323,0.0120315286472413,0.00843029201723419,0.0518851189801018,0.0414005586739676,0.0242552339493098,0.0908186950340554,0.118548641139213,0.0778647057399666,0.0359786580129867,0.0448324755571066,0.0578591537692776,0.0636367700728437,0.0437009407081254,0.0950722962222957,0.0730295104992266,0.0858045603858227,0.0594106303709034,0.0587939371085065,0.0426168357742144,0.0939411288242589,0.079032953835741,0.0606170337843957,2890,"glutamate ionotropic receptor AMPA type subunit 1","protein_coding","hsa04024,hsa04080,hsa04724,hsa04728,hsa04720,hsa04730,hsa04723,hsa04713,hsa05014,hsa05016,hsa05017,hsa05022,hsa05031,hsa05033","cAMP signaling pathway|Neuroactive ligand-receptor interaction|Glutamatergic synapse|Dopaminergic synapse|Long-term potentiation|Long-term depression|Retrograde endocannabinoid signaling|Circadian entrainment|Amyotrophic lateral sclerosis|Huntington disease|Spinocerebellar ataxia|Pathways of neurodegeneration - multiple diseases|Amphetamine addiction|Nicotine addiction","GO:0001540,GO:0001919,GO:0001965,GO:0004971,GO:0005515,GO:0005789,GO:0005886,GO:0005911,GO:0007165,GO:0007268,GO:0007416,GO:0007616,GO:0008066,GO:0008179,GO:0009410,GO:0009986,GO:0010226,GO:0010628,GO:0012507,GO:0014069,GO:0019228,GO:0019865,GO:0019901,GO:0021510,GO:0021987,GO:0030165,GO:0030425,GO:0030666,GO:0030672,GO:0031267,GO:0031489,GO:0031594,GO:0031623,GO:0031681,GO:0031698,GO:0031901,GO:0032281,GO:0032355,GO:0032591,GO:0032809,GO:0033116,GO:0034220,GO:0035235,GO:0035249,GO:0035254,GO:0042220,GO:0042802,GO:0043025,GO:0043197,GO:0043198,GO:0044308,GO:0044309,GO:0045838,GO:0046685,GO:0048787,GO:0050804,GO:0050806,GO:0051018,GO:0051602,GO:0055037,GO:0055038,GO:0060076,GO:0060078,GO:0060292,GO:0060992,GO:0071230,GO:0071242,GO:0071359,GO:0071375,GO:0071418,GO:0097060,GO:0097110,GO:0098793,GO:0098839,GO:0098978,GO:0099505,GO:0099507,GO:0099544,GO:0099566,GO:0099583,GO:1904315,GO:1990416","amyloid-beta binding|regulation of receptor recycling|G-protein alpha-subunit binding|AMPA glutamate receptor activity|protein binding|endoplasmic reticulum membrane|plasma membrane|cell-cell junction|signal transduction|chemical synaptic transmission|synapse assembly|long-term memory|glutamate receptor activity|adenylate cyclase binding|response to xenobiotic stimulus|cell surface|response to lithium ion|positive regulation of gene expression|ER to Golgi transport vesicle membrane|postsynaptic density|neuronal action potential|immunoglobulin binding|protein kinase binding|spinal cord development|cerebral cortex development|PDZ domain binding|dendrite|endocytic vesicle membrane|synaptic vesicle membrane|small GTPase binding|myosin V binding|neuromuscular junction|receptor internalization|G-protein beta-subunit binding|beta-2 adrenergic receptor binding|early endosome membrane|AMPA glutamate receptor complex|response to estradiol|dendritic spine membrane|neuronal cell body membrane|endoplasmic reticulum-Golgi intermediate compartment membrane|monoatomic ion transmembrane transport|ionotropic glutamate receptor signaling pathway|synaptic transmission, glutamatergic|glutamate receptor binding|response to cocaine|identical protein binding|neuronal cell body|dendritic spine|dendritic shaft|axonal spine|neuron spine|positive regulation of membrane potential|response to arsenic-containing substance|presynaptic active zone membrane|modulation of chemical synaptic transmission|positive regulation of synaptic transmission|protein kinase A binding|response to electrical stimulus|recycling endosome|recycling endosome membrane|excitatory synapse|regulation of postsynaptic membrane potential|long-term synaptic depression|response to fungicide|cellular response to amino acid stimulus|cellular response to ammonium ion|cellular response to dsRNA|cellular response to peptide hormone stimulus|cellular response to amine stimulus|synaptic membrane|scaffold protein binding|presynapse|postsynaptic density membrane|glutamatergic synapse|regulation of presynaptic membrane potential|ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential|perisynaptic space|regulation of postsynaptic cytosolic calcium ion concentration|neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration|transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential|cellular response to brain-derived neurotrophic factor stimulus","WP5083,WP3584,WP4549,WP2636,WP4222,WP2447,WP2380,WP4760,WP5398,WP3680,WP5094,WP4906","Neuroinflammation and glutamatergic signaling|MECP2 and associated Rett syndrome|Fragile X syndrome|Common pathways underlying drug addiction|Phosphodiesterases in neuronal function|Amyotrophic lateral sclerosis (ALS)|Brain-derived neurotrophic factor (BDNF) signaling pathway|PKC-gamma calcium signaling pathway in ataxia|NRXN1 deletion syndrome|Physico-chemical features and toxicity-associated pathways|Orexin receptor pathway|3q29 copy number variation syndrome","R-HSA-112314,R-HSA-112314,R-HSA-112315,R-HSA-112315,R-HSA-112316,R-HSA-112316,R-HSA-199977,R-HSA-199991,R-HSA-204005,R-HSA-392499,R-HSA-399710,R-HSA-399719,R-HSA-399721,R-HSA-416993,R-HSA-438064,R-HSA-438066,R-HSA-438066,R-HSA-442755,R-HSA-442755,R-HSA-446203,R-HSA-5653656,R-HSA-5694530,R-HSA-597592,R-HSA-6794362,R-HSA-8849932,R-HSA-948021,R-HSA-9620244","Neurotransmitter receptors and postsynaptic signal transmission|Neurotransmitter receptors and postsynaptic signal transmission|Transmission across Chemical Synapses|Transmission across Chemical Synapses|Neuronal System|Neuronal System|ER to Golgi Anterograde Transport|Membrane Trafficking|COPII-mediated vesicle transport|Metabolism of proteins|Activation of AMPA receptors|Trafficking of AMPA receptors|Glutamate binding, activation of AMPA receptors and synaptic plasticity|Trafficking of GluR2-containing AMPA receptors|Post NMDA receptor activation events|Unblocking of NMDA receptors, glutamate binding and activation|Unblocking of NMDA receptors, glutamate binding and activation|Activation of NMDA receptors and postsynaptic events|Activation of NMDA receptors and postsynaptic events|Asparagine N-linked glycosylation|Vesicle-mediated transport|Cargo concentration in the ER|Post-translational protein modification|Protein-protein interactions at synapses|Synaptic adhesion-like molecules|Transport to the Golgi and subsequent modification|Long-term potentiation"]
["GRK2",16.9682439861667,20.341221026685,19.8156843250614,20.8497870975319,16.6616787169212,19.8414617637522,18.3630880741448,18.6717601359663,18.1671865299596,24.9603898781326,21.55807250859,20.3249762700669,17.2406229387924,20.6759845168589,18.0026633786279,18.5113925265968,19.7492150588737,20.589404685653,21.1583688151222,20.7750282961568,22.1556136574196,21.5315275983991,18.0834666272356,19.0814428723811,19.6551444596884,21.0077379839919,18.1705315094533,23.0387908411667,156,"G protein-coupled receptor kinase 2","protein_coding","hsa04340,hsa04144,hsa04062,hsa04724,hsa04740,hsa05032","Hedgehog signaling pathway|Endocytosis|Chemokine signaling pathway|Glutamatergic synapse|Olfactory transduction|Morphine addiction","GO:0001664,GO:0002026,GO:0002029,GO:0003108,GO:0004672,GO:0004703,GO:0005515,GO:0005524,GO:0005737,GO:0005829,GO:0005886,GO:0005929,GO:0006468,GO:0007186,GO:0007213,GO:0007217,GO:0007507,GO:0016020,GO:0018105,GO:0019079,GO:0031623,GO:0031694,GO:0031755,GO:0033605,GO:0045988,GO:0046718,GO:0047696,GO:0060048,GO:0098793,GO:0098794,GO:1901081","G protein-coupled receptor binding|regulation of the force of heart contraction|desensitization of G protein-coupled receptor signaling pathway|negative regulation of the force of heart contraction by chemical signal|protein kinase activity|G protein-coupled receptor kinase activity|protein binding|ATP binding|cytoplasm|cytosol|plasma membrane|cilium|protein phosphorylation|G protein-coupled receptor signaling pathway|G protein-coupled acetylcholine receptor signaling pathway|tachykinin receptor signaling pathway|heart development|membrane|peptidyl-serine phosphorylation|viral genome replication|receptor internalization|alpha-2A adrenergic receptor binding|Edg-2 lysophosphatidic acid receptor binding|positive regulation of catecholamine secretion|negative regulation of striated muscle contraction|viral entry into host cell|beta-adrenergic receptor kinase activity|cardiac muscle contraction|presynapse|postsynapse|negative regulation of relaxation of smooth muscle","WP3929,WP47,WP4249","Chemokine signaling pathway|Hedgehog signaling pathway|Hedgehog signaling pathway","R-HSA-111885,R-HSA-111933,R-HSA-111996,R-HSA-111997,R-HSA-112040,R-HSA-112043,R-HSA-1489509,R-HSA-162582,R-HSA-162582,R-HSA-199991,R-HSA-372790,R-HSA-388396,R-HSA-416476,R-HSA-418555,R-HSA-418594,R-HSA-5358351,R-HSA-5358351,R-HSA-5632684,R-HSA-5632684,R-HSA-5635838,R-HSA-5635838,R-HSA-5653656,R-HSA-8856825,R-HSA-8856828,R-HSA-9006925","Opioid Signalling|Calmodulin induced events|Ca-dependent events|CaM pathway|G-protein mediated events|PLC beta mediated events|DAG and IP3 signaling|Signal Transduction|Signal Transduction|Membrane Trafficking|Signaling by GPCR|GPCR downstream signalling|G alpha (q) signalling events|G alpha (s) signalling events|G alpha (i) signalling events|Signaling by Hedgehog|Signaling by Hedgehog|Hedgehog 'on' state|Hedgehog 'on' state|Activation of SMO|Activation of SMO|Vesicle-mediated transport|Cargo recognition for clathrin-mediated endocytosis|Clathrin-mediated endocytosis|Intracellular signaling by second messengers"]
["GSC",1.51333138162768,1.19202732647705,1.19877440661236,1.20191815978691,1.08596710926148,1.22125376310306,1.27955658962494,1.13616302665074,1.49842175517732,3.23389932360631,3.73590177078194,2.16485744890681,2.36112962798913,2.95318253139835,3.29856965496256,2.28682091948156,2.25066670272098,1.42211085708564,2.31651925942179,2.93324140654813,2.52194887029695,2.2026682966412,2.17095600652894,1.5708885346683,2.71938776739047,2.87587402035418,2.17375286624531,2.00068115190497,145258,"goosecoid homeobox","protein_coding",null,null,"GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001227,GO:0005634,GO:0005667,GO:0006357,GO:0007369,GO:0014036,GO:0016055,GO:0021904,GO:0023019,GO:0030178,GO:0030900,GO:0042474,GO:0048644,GO:0048704,GO:0061629,GO:1990837","negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|nucleus|transcription regulator complex|regulation of transcription by RNA polymerase II|gastrulation|neural crest cell fate specification|Wnt signaling pathway|dorsal/ventral neural tube patterning|signal transduction involved in regulation of gene expression|negative regulation of Wnt signaling pathway|forebrain development|middle ear morphogenesis|muscle organ morphogenesis|embryonic skeletal system morphogenesis|RNA polymerase II-specific DNA-binding transcription factor binding|sequence-specific double-stranded DNA binding",null,null,"R-HSA-1266738,R-HSA-9754189,R-HSA-9758941,R-HSA-9823730","Developmental Biology|Germ layer formation at gastrulation|Gastrulation|Formation of definitive endoderm"]
["GSG1",0.00732704953390679,0,0.00687889635638757,0,0,0,0,0.0431092915792951,7.37001859935259E-3,0,0,0,0,0,0,0,0.0140890285903444,0,0,0.00704584622014508,0,6.96463063435321E-3,0,0,0,0,0.0141805025251121,0,83445,"germ cell associated 1","protein_coding",null,null,"GO:0005515,GO:0005789,GO:0005886","protein binding|endoplasmic reticulum membrane|plasma membrane"]
["GSTP1",312.452000884619,318.68132588835,401.162512252672,388.591131021965,294.721875708246,365.282978709401,400.70146146186,402.062589431101,334.080357137214,407.968837747258,415.191427566023,378.694505897528,316.962192697969,384.312573463595,357.328130212457,351.473682798147,445.16683437813,442.75612341076,500.959897901086,398.794896060211,414.464871522866,445.443846111962,429.199259454548,418.560051420558,400.190008845686,491.007096864557,483.682014286812,495.79272921652,2950,"glutathione S-transferase pi 1","protein_coding","hsa00480,hsa00980,hsa00982,hsa00983,hsa05200,hsa05204,hsa05225,hsa05215,hsa05418,hsa01524","Glutathione metabolism|Metabolism of xenobiotics by cytochrome P450|Drug metabolism - cytochrome P450|Drug metabolism - other enzymes|Pathways in cancer|Chemical carcinogenesis - DNA adducts|Hepatocellular carcinoma|Prostate cancer|Fluid shear stress and atherosclerosis|Platinum drug resistance","GO:0000302,GO:0002674,GO:0004364,GO:0004602,GO:0005504,GO:0005515,GO:0005576,GO:0005615,GO:0005634,GO:0005737,GO:0005739,GO:0005829,GO:0006469,GO:0006693,GO:0006749,GO:0006805,GO:0007417,GO:0008432,GO:0009890,GO:0010804,GO:0019207,GO:0031982,GO:0032691,GO:0032720,GO:0032872,GO:0032873,GO:0032930,GO:0034774,GO:0035726,GO:0035730,GO:0035731,GO:0035732,GO:0043066,GO:0043124,GO:0043407,GO:0043409,GO:0043508,GO:0043651,GO:0048147,GO:0051122,GO:0051771,GO:0070026,GO:0070062,GO:0070372,GO:0070373,GO:0070664,GO:0071222,GO:0071638,GO:0097057,GO:0098869,GO:1901687,GO:1904813,GO:2001237","response to reactive oxygen species|negative regulation of acute inflammatory response|glutathione transferase activity|glutathione peroxidase activity|fatty acid binding|protein binding|extracellular region|extracellular space|nucleus|cytoplasm|mitochondrion|cytosol|negative regulation of protein kinase activity|prostaglandin metabolic process|glutathione metabolic process|xenobiotic metabolic process|central nervous system development|JUN kinase binding|negative regulation of biosynthetic process|negative regulation of tumor necrosis factor-mediated signaling pathway|kinase regulator activity|vesicle|negative regulation of interleukin-1 beta production|negative regulation of tumor necrosis factor production|regulation of stress-activated MAPK cascade|negative regulation of stress-activated MAPK cascade|positive regulation of superoxide anion generation|secretory granule lumen|common myeloid progenitor cell proliferation|S-nitrosoglutathione binding|dinitrosyl-iron complex binding|nitric oxide storage|negative regulation of apoptotic process|negative regulation of canonical NF-kappaB signal transduction|negative regulation of MAP kinase activity|negative regulation of MAPK cascade|negative regulation of JUN kinase activity|linoleic acid metabolic process|negative regulation of fibroblast proliferation|hepoxilin biosynthetic process|negative regulation of nitric-oxide synthase biosynthetic process|nitric oxide binding|extracellular exosome|regulation of ERK1 and ERK2 cascade|negative regulation of ERK1 and ERK2 cascade|negative regulation of leukocyte proliferation|cellular response to lipopolysaccharide|negative regulation of monocyte chemotactic protein-1 production|TRAF2-GSTP1 complex|cellular oxidant detoxification|glutathione derivative biosynthetic process|ficolin-1-rich granule lumen|negative regulation of extrinsic apoptotic signaling pathway","WP702,WP3612,WP2882,WP678,WP2884,WP410","Metapathway biotransformation Phase I and II|Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling|Nuclear receptors meta-pathway|Arachidonate epoxygenase / epoxide hydrolase|NRF2 pathway|Exercise-induced circadian regulation","R-HSA-1430728,R-HSA-156580,R-HSA-156590,R-HSA-168249,R-HSA-168256,R-HSA-211859,R-HSA-2262752,R-HSA-3299685,R-HSA-6798695,R-HSA-8953897,R-HSA-9711123,R-HSA-9748784,R-HSA-9753281","Metabolism|Phase II - Conjugation of compounds|Glutathione conjugation|Innate Immune System|Immune System|Biological oxidations|Cellular responses to stress|Detoxification of Reactive Oxygen Species|Neutrophil degranulation|Cellular responses to stimuli|Cellular response to chemical stress|Drug ADME|Paracetamol ADME"]
["GTPBP10",2.74997308582263,2.33494006502463,2.78115093191458,2.10921697739824,2.57108960044082,2.34576075751495,2.61271550105708,2.08246449002835,2.2049149074715,1.14401866920374,1.56051559479041,1.81791113539475,2.16335917997012,1.7741509127948,1.99843373461025,1.89752626938358,2.65085383341233,1.96162691146754,2.77112471767665,2.23253785783474,2.46986528291607,2.26838921842832,3.42196357250506,3.14731718662288,2.53368441406689,2.17177402203898,2.96412929230834,2.13523535231128,85865,"GTP binding protein 10","protein_coding",null,null,"GO:0000287,GO:0003723,GO:0003924,GO:0005515,GO:0005525,GO:0005694,GO:0005730,GO:0005739,GO:0042254","magnesium ion binding|RNA binding|GTPase activity|protein binding|GTP binding|chromosome|nucleolus|mitochondrion|ribosome biogenesis"]
["GYG2",8.32514347964802,8.57210253879323,10.9725130294318,10.3606594860852,9.64198655301506,10.9063909569645,11.9884852662837,11.7329492068877,10.359014773229,10.9607608639644,11.2456200266294,11.3760676138324,10.7600781869253,13.072714247466,11.739258794825,12.4605040594821,12.5789085912608,13.5596478643445,10.3220829113596,12.0260234179328,10.927654368215,14.0272740926092,9.97217878725021,11.6538802355002,12.0001706438178,12.7719013708135,10.9064867236993,12.7603096678711,8908,"glycogenin 2","protein_coding","hsa00500","Starch and sucrose metabolism","GO:0005737,GO:0005829,GO:0005978,GO:0008466,GO:0016757,GO:0046872,GO:0102751","cytoplasm|cytosol|glycogen biosynthetic process|glycogenin glucosyltransferase activity|glycosyltransferase activity|metal ion binding|UDP-alpha-D-glucose:glucosyl-glycogenin alpha-D-glucosyltransferase activity","WP5173,WP500","Disorders of galactose metabolism |Glycogen synthesis and degradation","R-HSA-1430728,R-HSA-1643685,R-HSA-3229121,R-HSA-3322077,R-HSA-3858516,R-HSA-3878781,R-HSA-5663084,R-HSA-5668914,R-HSA-70221,R-HSA-71387,R-HSA-8982491","Metabolism|Disease|Glycogen storage diseases|Glycogen synthesis|Glycogen storage disease type 0 (liver GYS2)|Glycogen storage disease type IV (GBE1)|Diseases of carbohydrate metabolism|Diseases of metabolism|Glycogen breakdown (glycogenolysis)|Metabolism of carbohydrates|Glycogen metabolism"]
["GZMB",0,0,0,0,0,0.0280013936029263,0,0,0.149968464751206,0.14359673863078,0.308471661699362,0.210001488406549,0.0283574354815382,0.255857366514786,0.526895418336941,0.537182686057291,0.0573379825042889,0.19313214158515,0.110236765559394,0.0573488235484818,0.0562890929622235,0.170063336972027,0.0294377420240151,0.262189555662689,0.118252290769955,0.339998933545745,0.173130759258476,0.308364572823112,3002,"granzyme B","protein_coding","hsa04210,hsa04650,hsa05202,hsa05320,hsa05330,hsa05332,hsa04940","Apoptosis|Natural killer cell mediated cytotoxicity|Transcriptional misregulation in cancer|Autoimmune thyroid disease|Allograft rejection|Graft-versus-host disease|Type I diabetes mellitus","GO:0001772,GO:0004252,GO:0005515,GO:0005576,GO:0005634,GO:0005737,GO:0005739,GO:0005829,GO:0006915,GO:0008236,GO:0016020,GO:0017148,GO:0031640,GO:0042267,GO:0043231,GO:0044194,GO:0051603,GO:0051604,GO:0070269,GO:0140507,GO:1900740","immunological synapse|serine-type endopeptidase activity|protein binding|extracellular region|nucleus|cytoplasm|mitochondrion|cytosol|apoptotic process|serine-type peptidase activity|membrane|negative regulation of translation|killing of cells of another organism|natural killer cell mediated cytotoxicity|intracellular membrane-bounded organelle|cytolytic granule|proteolysis involved in protein catabolic process|protein maturation|pyroptosis|granzyme-mediated programmed cell death signaling pathway|positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway","WP5092,WP5413,WP623,WP4329,WP2328,WP3657,WP254","Interactions of natural killer cells in pancreatic cancer|IL-24 Signaling pathway|Oxidative phosphorylation|miRNA role in immune response in sepsis|Allograft rejection|Hematopoietic stem cell gene regulation by GABP alpha/beta complex|Apoptosis","R-HSA-109581,R-HSA-109606,R-HSA-157118,R-HSA-162582,R-HSA-1980145,R-HSA-2197563,R-HSA-5218859,R-HSA-5357801,R-HSA-5620971,R-HSA-75108","Apoptosis|Intrinsic Pathway for Apoptosis|Signaling by NOTCH|Signal Transduction|Signaling by NOTCH2|NOTCH2 intracellular domain regulates transcription|Regulated Necrosis|Programmed Cell Death|Pyroptosis|Activation, myristolyation of BID and translocation to mitochondria"]
["H2AW",4.22842591925382,3.31809604306821,5.50809416894438,4.86636786559675,4.18348781264935,4.96338427785203,6.75595497524085,4.2500408055747,5.36969439437027,5.09064516557746,5.11985977970607,4.94544681605473,5.78046861306022,7.96179071329847,5.80030836582437,6.26435949684973,3.35393469425087,3.42336188221522,5.22695189168093,5.28598724973928,4.39010776797137,4.72264775246241,4.74836550953643,4.54416198955953,4.92578757866064,4.72087408120641,6.18880227801607,3.87582936878846,92815,"H2A.W histone","protein_coding","hsa03082,hsa04217,hsa04613,hsa05322,hsa05034","ATP-dependent chromatin remodeling|Necroptosis|Neutrophil extracellular trap formation|Systemic lupus erythematosus|Alcoholism","GO:0000786,GO:0003677,GO:0005515,GO:0005634,GO:0006337,GO:0030527,GO:0046982,GO:0070062,GO:0070914","nucleosome|DNA binding|protein binding|nucleus|nucleosome disassembly|structural constituent of chromatin|protein heterodimerization activity|extracellular exosome|UV-damage excision repair",null,null,"R-HSA-1643685,R-HSA-3214815,R-HSA-3214847,R-HSA-3214847,R-HSA-3214858,R-HSA-3247509,R-HSA-3247509,R-HSA-392499,R-HSA-4839726,R-HSA-4839726,R-HSA-5663205,R-HSA-5688426,R-HSA-5689603,R-HSA-5689880,R-HSA-5689901,R-HSA-597592,R-HSA-9609646,R-HSA-9609690,R-HSA-9610379,R-HSA-9824446","Disease|HDACs deacetylate histones|HATs acetylate histones|HATs acetylate histones|RMTs methylate histone arginines|Chromatin modifying enzymes|Chromatin modifying enzymes|Metabolism of proteins|Chromatin organization|Chromatin organization|Infectious disease|Deubiquitination|UCH proteinases|Ub-specific processing proteases|Metalloprotease DUBs|Post-translational protein modification|HCMV Infection|HCMV Early Events|HCMV Late Events|Viral Infection Pathways"]
["H3-3A",83.5425866271878,80.23617999831,93.46119498678,79.966255633251,80.0630505700035,83.133359988956,101.375020756737,87.8035141775519,110.856045847728,93.9479930091548,112.566218737355,111.861704359165,111.045436586817,105.398753949687,123.631805604042,110.251383582196,132.606305371219,120.813141752321,146.792666061243,114.58002819612,117.135187908844,115.302942467034,142.583163542184,138.084781064201,121.050716964664,117.800363299808,153.048519499556,126.081352824496,3020,"H3.3 histone A","protein_coding","hsa04613,hsa05202,hsa05131,hsa05322,hsa05034","Neutrophil extracellular trap formation|Transcriptional misregulation in cancer|Shigellosis|Systemic lupus erythematosus|Alcoholism","GO:0000781,GO:0000786,GO:0000939,GO:0000978,GO:0000979,GO:0001556,GO:0001649,GO:0001740,GO:0005515,GO:0005576,GO:0005634,GO:0005654,GO:0006334,GO:0006997,GO:0007286,GO:0007338,GO:0007566,GO:0008283,GO:0008584,GO:0030307,GO:0030527,GO:0031492,GO:0031508,GO:0031509,GO:0032200,GO:0032991,GO:0035264,GO:0042692,GO:0046982,GO:0070062,GO:0090230,GO:1902340","chromosome, telomeric region|nucleosome|inner kinetochore|RNA polymerase II cis-regulatory region sequence-specific DNA binding|RNA polymerase II core promoter sequence-specific DNA binding|oocyte maturation|osteoblast differentiation|Barr body|protein binding|extracellular region|nucleus|nucleoplasm|nucleosome assembly|nucleus organization|spermatid development|single fertilization|embryo implantation|cell population proliferation|male gonad development|positive regulation of cell growth|structural constituent of chromatin|nucleosomal DNA binding|pericentric heterochromatin formation|subtelomeric heterochromatin formation|telomere organization|protein-containing complex|multicellular organism growth|muscle cell differentiation|protein heterodimerization activity|extracellular exosome|regulation of centromere complex assembly|negative regulation of chromosome condensation","WP4204,WP4320,WP5351,WP5114,WP5380,WP5365,WP5180,WP4352,WP4553,WP2361,WP2369","Tumor suppressor activity of SMARCB1|Effect of progerin on genes involved in Hutchinson-Gilford progeria syndrome|Kleefstra syndrome|Nucleotide excision repair in xeroderma pigmentosum |5q35 copy number variation|4p16.3 copy number variation|DYRK1A involvement regarding cell proliferation in brain development|Ciliary landscape|FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma|Gastric cancer network 1|Histone modifications","R-HSA-109582,R-HSA-1266738,R-HSA-1474165,R-HSA-1500620,R-HSA-157118,R-HSA-157579,R-HSA-162582,R-HSA-162582,R-HSA-1640170,R-HSA-1640170,R-HSA-1643685,R-HSA-1912408,R-HSA-1912422,R-HSA-194315,R-HSA-195258,R-HSA-195721,R-HSA-201681,R-HSA-201722,R-HSA-211000,R-HSA-212165,R-HSA-212165,R-HSA-212300,R-HSA-212436,R-HSA-212436,R-HSA-2262752,R-HSA-2299718,R-HSA-2559580,R-HSA-2559582,R-HSA-2559583,R-HSA-392499,R-HSA-427359,R-HSA-427389,R-HSA-427413,R-HSA-427413,R-HSA-5250913,R-HSA-5250913,R-HSA-5250924,R-HSA-5250941,R-HSA-5250941,R-HSA-5334118,R-HSA-5578749,R-HSA-5617472,R-HSA-5619507,R-HSA-5625740,R-HSA-5625886,R-HSA-68616,R-HSA-68867,R-HSA-68875,R-HSA-68886,R-HSA-69002,R-HSA-69278,R-HSA-69306,R-HSA-73728,R-HSA-73772,R-HSA-73854,R-HSA-73857,R-HSA-73857,R-HSA-73864,R-HSA-73886,R-HSA-74160,R-HSA-74160,R-HSA-8878171,R-HSA-8878171,R-HSA-8936459,R-HSA-8939211,R-HSA-8939236,R-HSA-8953897,R-HSA-9006931,R-HSA-9018519,R-HSA-912446,R-HSA-9616222,R-HSA-9645723,R-HSA-9670095,R-HSA-9710421,R-HSA-9716542,R-HSA-977225,R-HSA-983231","Hemostasis|Developmental Biology|Reproduction|Meiosis|Signaling by NOTCH|Telomere Maintenance|Signal Transduction|Signal Transduction|Cell Cycle|Cell Cycle|Disease|Pre-NOTCH Transcription and Translation|Pre-NOTCH Expression and Processing|Signaling by Rho GTPases|RHO GTPase Effectors|Signaling by WNT|TCF dependent signaling in response to WNT|Formation of the beta-catenin:TCF transactivating complex|Gene Silencing by RNA|Epigenetic regulation of gene expression|Epigenetic regulation of gene expression|PRC2 methylates histones and DNA|Generic Transcription Pathway|Generic Transcription Pathway|Cellular responses to stress|Condensation of Prophase Chromosomes|Oxidative Stress Induced Senescence|Senescence-Associated Secretory Phenotype (SASP)|Cellular Senescence|Metabolism of proteins|SIRT1 negatively regulates rRNA expression|ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression|NoRC negatively regulates rRNA expression|NoRC negatively regulates rRNA expression|Positive epigenetic regulation of rRNA expression|Positive epigenetic regulation of rRNA expression|B-WICH complex positively regulates rRNA expression|Negative epigenetic regulation of rRNA expression|Negative epigenetic regulation of rRNA expression|DNA methylation|Transcriptional regulation by small RNAs|Activation of anterior HOX genes in hindbrain development during early embryogenesis|Activation of HOX genes during differentiation|RHO GTPases activate PKNs|Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3|Assembly of the ORC complex at the origin of replication|Assembly of the pre-replicative complex|Mitotic Prophase|M Phase|DNA Replication Pre-Initiation|Cell Cycle, Mitotic|DNA Replication|RNA Polymerase I Promoter Opening|RNA Polymerase I Promoter Escape|RNA Polymerase I Promoter Clearance|RNA Polymerase II Transcription|RNA Polymerase II Transcription|RNA Polymerase I Transcription|Chromosome Maintenance|Gene expression (Transcription)|Gene expression (Transcription)|Transcriptional regulation by RUNX1|Transcriptional regulation by RUNX1|RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function|ESR-mediated signaling|RUNX1 regulates transcription of genes involved in differentiation of HSCs|Cellular responses to stimuli|Signaling by Nuclear Receptors|Estrogen-dependent gene expression|Meiotic recombination|Transcriptional regulation of granulopoiesis|Diseases of programmed cell death|Inhibition of DNA recombination at telomere|Defective pyroptosis|Signaling by Rho GTPases, Miro GTPases and RHOBTB3|Amyloid fiber formation|Factors involved in megakaryocyte development and platelet production"]
["H3C7",0.0545672373183059,0.0519024960730213,0.0512296754962548,0,0,0.20496566653478,0.0509107396402499,0.321050776761593,0,0.105110487224474,0,0.219596698113962,0,0,0,0.0517380298525241,0.209852373214077,0.30293485713067,0.403457635893492,0,0.154510141815334,0.259340851252889,0,0.533106968778837,0.0540992261417203,0.311092141624851,0.36962599345062,0,8968,"H3 clustered histone 7","protein_coding","hsa04613,hsa05202,hsa05131,hsa05322,hsa05034","Neutrophil extracellular trap formation|Transcriptional misregulation in cancer|Shigellosis|Systemic lupus erythematosus|Alcoholism","GO:0000786,GO:0003677,GO:0005515,GO:0005576,GO:0005634,GO:0005654,GO:0006325,GO:0006334,GO:0010467,GO:0016020,GO:0030527,GO:0032200,GO:0032991,GO:0040029,GO:0045296,GO:0046982,GO:0070062","nucleosome|DNA binding|protein binding|extracellular region|nucleus|nucleoplasm|chromatin organization|nucleosome assembly|gene expression|membrane|structural constituent of chromatin|telomere organization|protein-containing complex|epigenetic regulation of gene expression|cadherin binding|protein heterodimerization activity|extracellular exosome","WP4320,WP5366,WP4553,WP2369","Effect of progerin on genes involved in Hutchinson-Gilford progeria syndrome|NF1 copy number variation syndrome |FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma|Histone modifications","R-HSA-109582,R-HSA-1266695,R-HSA-1266695,R-HSA-1266738,R-HSA-1280215,R-HSA-1280215,R-HSA-1474165,R-HSA-1500620,R-HSA-157118,R-HSA-162582,R-HSA-162582,R-HSA-1640170,R-HSA-1640170,R-HSA-1643685,R-HSA-168256,R-HSA-168256,R-HSA-1912408,R-HSA-1912422,R-HSA-194315,R-HSA-195258,R-HSA-195721,R-HSA-201681,R-HSA-201722,R-HSA-211000,R-HSA-212165,R-HSA-212165,R-HSA-212300,R-HSA-212436,R-HSA-212436,R-HSA-2262752,R-HSA-2299718,R-HSA-2559580,R-HSA-2559582,R-HSA-2559583,R-HSA-3214815,R-HSA-3214841,R-HSA-3214842,R-HSA-3214847,R-HSA-3214847,R-HSA-3214858,R-HSA-3247509,R-HSA-3247509,R-HSA-392499,R-HSA-427359,R-HSA-427389,R-HSA-427413,R-HSA-427413,R-HSA-449147,R-HSA-449147,R-HSA-4839726,R-HSA-4839726,R-HSA-5250913,R-HSA-5250913,R-HSA-5250924,R-HSA-5250941,R-HSA-5250941,R-HSA-5334118,R-HSA-5578749,R-HSA-5617472,R-HSA-5619507,R-HSA-5625740,R-HSA-5625886,R-HSA-5663205,R-HSA-68616,R-HSA-68867,R-HSA-68875,R-HSA-68886,R-HSA-69002,R-HSA-69278,R-HSA-69306,R-HSA-73728,R-HSA-73772,R-HSA-73854,R-HSA-73857,R-HSA-73857,R-HSA-73864,R-HSA-74160,R-HSA-74160,R-HSA-8878171,R-HSA-8878171,R-HSA-8936459,R-HSA-8939211,R-HSA-8939236,R-HSA-8953897,R-HSA-9006931,R-HSA-9018519,R-HSA-912446,R-HSA-9609646,R-HSA-9609690,R-HSA-9610379,R-HSA-9616222,R-HSA-9645723,R-HSA-9710421,R-HSA-9716542,R-HSA-977225,R-HSA-9824446,R-HSA-983231","Hemostasis|Interleukin-7 signaling|Interleukin-7 signaling|Developmental Biology|Cytokine Signaling in Immune system|Cytokine Signaling in Immune system|Reproduction|Meiosis|Signaling by NOTCH|Signal Transduction|Signal Transduction|Cell Cycle|Cell Cycle|Disease|Immune System|Immune System|Pre-NOTCH Transcription and Translation|Pre-NOTCH Expression and Processing|Signaling by Rho GTPases|RHO GTPase Effectors|Signaling by WNT|TCF dependent signaling in response to WNT|Formation of the beta-catenin:TCF transactivating complex|Gene Silencing by RNA|Epigenetic regulation of gene expression|Epigenetic regulation of gene expression|PRC2 methylates histones and DNA|Generic Transcription Pathway|Generic Transcription Pathway|Cellular responses to stress|Condensation of Prophase Chromosomes|Oxidative Stress Induced Senescence|Senescence-Associated Secretory Phenotype (SASP)|Cellular Senescence|HDACs deacetylate histones|PKMTs methylate histone lysines|HDMs demethylate histones|HATs acetylate histones|HATs acetylate histones|RMTs methylate histone arginines|Chromatin modifying enzymes|Chromatin modifying enzymes|Metabolism of proteins|SIRT1 negatively regulates rRNA expression|ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression|NoRC negatively regulates rRNA expression|NoRC negatively regulates rRNA expression|Signaling by Interleukins|Signaling by Interleukins|Chromatin organization|Chromatin organization|Positive epigenetic regulation of rRNA expression|Positive epigenetic regulation of rRNA expression|B-WICH complex positively regulates rRNA expression|Negative epigenetic regulation of rRNA expression|Negative epigenetic regulation of rRNA expression|DNA methylation|Transcriptional regulation by small RNAs|Activation of anterior HOX genes in hindbrain development during early embryogenesis|Activation of HOX genes during differentiation|RHO GTPases activate PKNs|Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3|Infectious disease|Assembly of the ORC complex at the origin of replication|Assembly of the pre-replicative complex|Mitotic Prophase|M Phase|DNA Replication Pre-Initiation|Cell Cycle, Mitotic|DNA Replication|RNA Polymerase I Promoter Opening|RNA Polymerase I Promoter Escape|RNA Polymerase I Promoter Clearance|RNA Polymerase II Transcription|RNA Polymerase II Transcription|RNA Polymerase I Transcription|Gene expression (Transcription)|Gene expression (Transcription)|Transcriptional regulation by RUNX1|Transcriptional regulation by RUNX1|RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function|ESR-mediated signaling|RUNX1 regulates transcription of genes involved in differentiation of HSCs|Cellular responses to stimuli|Signaling by Nuclear Receptors|Estrogen-dependent gene expression|Meiotic recombination|HCMV Infection|HCMV Early Events|HCMV Late Events|Transcriptional regulation of granulopoiesis|Diseases of programmed cell death|Defective pyroptosis|Signaling by Rho GTPases, Miro GTPases and RHOBTB3|Amyloid fiber formation|Viral Infection Pathways|Factors involved in megakaryocyte development and platelet production"]
["HACL1",6.01114207336431,4.97736928493195,5.71905759163665,5.3661152624464,5.72961137108421,5.43056992590669,7.13561277645673,5.71030382732524,6.47827936534033,5.16919668381186,7.41973522420108,7.49213871601606,6.68631346832391,6.30653527179791,7.12517315812621,5.71219783447932,9.18503677524155,8.75254045900934,11.0368457066284,7.85778793456619,9.08033569117433,9.0426177986978,11.8686411326928,11.2735273576904,9.2187343334041,8.50375298499298,12.5036775123598,9.23360659057389,26061,"2-hydroxyacyl-CoA lyase 1","protein_coding","hsa04146","Peroxisome","GO:0000287,GO:0001561,GO:0005515,GO:0005524,GO:0005654,GO:0005777,GO:0005782,GO:0005829,GO:0006625,GO:0006631,GO:0016830,GO:0030976,GO:0042802,GO:0043231,GO:0097089,GO:0106359,GO:0106376,GO:1903512","magnesium ion binding|fatty acid alpha-oxidation|protein binding|ATP binding|nucleoplasm|peroxisome|peroxisomal matrix|cytosol|protein targeting to peroxisome|fatty acid metabolic process|carbon-carbon lyase activity|thiamine pyrophosphate binding|identical protein binding|intracellular membrane-bounded organelle|methyl-branched fatty acid metabolic process|2-hydroxyacyl-CoA lyase activity|2-hydroxyphytanoyl-CoA lyase activity|phytanic acid metabolic process",null,null,"R-HSA-1430728,R-HSA-389599,R-HSA-390918,R-HSA-556833,R-HSA-8978868,R-HSA-9033241,R-HSA-9033241,R-HSA-9609507,R-HSA-9609507","Metabolism|Alpha-oxidation of phytanate|Peroxisomal lipid metabolism|Metabolism of lipids|Fatty acid metabolism|Peroxisomal protein import|Peroxisomal protein import|Protein localization|Protein localization"]
["HAS2",4.34223938812996,3.71293808935956,2.70980818433916,2.59745254146902,3.07512665473832,3.46266289950149,2.63955374884814,2.50616476633377,0.844124384992076,0.783767255681361,1.03435892188007,0.985025849393738,1.09432948661113,1.06676966567003,1.78558421511086,1.3020412116471,1.94987005220009,1.69414889912322,1.75687245186568,2.06028353731107,1.96820654863382,1.87337065853148,2.30969634778612,2.52795804077206,2.02958860941301,1.52833797344957,1.88255201057849,1.73329451996799,3037,"hyaluronan synthase 2","protein_coding",null,null,"GO:0000139,GO:0001570,GO:0001822,GO:0005515,GO:0005764,GO:0005789,GO:0005794,GO:0005886,GO:0008284,GO:0010838,GO:0014911,GO:0030213,GO:0030335,GO:0031410,GO:0035810,GO:0036120,GO:0036302,GO:0042802,GO:0044849,GO:0044853,GO:0045226,GO:0050501,GO:0051549,GO:0060349,GO:0070295,GO:0071347,GO:0071356,GO:0071498,GO:0085029,GO:0090500,GO:1900026,GO:1900127,GO:1900625,GO:1901201,GO:1903561","Golgi membrane|vasculogenesis|kidney development|protein binding|lysosome|endoplasmic reticulum membrane|Golgi apparatus|plasma membrane|positive regulation of cell population proliferation|positive regulation of keratinocyte proliferation|positive regulation of smooth muscle cell migration|hyaluronan biosynthetic process|positive regulation of cell migration|cytoplasmic vesicle|positive regulation of urine volume|cellular response to platelet-derived growth factor stimulus|atrioventricular canal development|identical protein binding|estrous cycle|plasma membrane raft|extracellular polysaccharide biosynthetic process|hyaluronan synthase activity|positive regulation of keratinocyte migration|bone morphogenesis|renal water absorption|cellular response to interleukin-1|cellular response to tumor necrosis factor|cellular response to fluid shear stress|extracellular matrix assembly|endocardial cushion to mesenchymal transition|positive regulation of substrate adhesion-dependent cell spreading|positive regulation of hyaluronan biosynthetic process|positive regulation of monocyte aggregation|regulation of extracellular matrix assembly|extracellular vesicle",null,null,"R-HSA-1430728,R-HSA-1630316,R-HSA-2142845,R-HSA-2142850,R-HSA-71387","Metabolism|Glycosaminoglycan metabolism|Hyaluronan metabolism|Hyaluronan biosynthesis and export|Metabolism of carbohydrates"]
["HCFC1R1",30.8415783980668,43.4752406587084,55.5767221416317,54.5288064438455,33.7922167856862,51.0797561572249,60.7920720968356,58.1198671466543,42.2371345237347,60.7568728382985,63.0024309368599,54.2161049424592,47.0933479657451,65.3875021002746,56.8487956255626,52.4442979628117,42.7383051256498,54.0811493048969,68.8968928842713,50.5205655926591,47.4459101606274,52.5762148879823,52.4848849541006,45.1970665371192,38.783575393384,59.9629870892867,55.3226915681484,63.7292472445959,54985,"host cell factor C1 regulator 1","protein_coding",null,null,"GO:0005654,GO:0005737","nucleoplasm|cytoplasm"]
["HDAC10",8.21182715775618,12.3155099973001,14.1867684072149,15.2376129566388,10.0970125279543,11.8726781533785,10.747739074548,12.9025225231427,9.1894973243108,15.8484257770726,14.1814157596436,11.7482094839839,7.58967373324348,14.5666931274825,9.26786278903468,10.7929520973538,9.57113211965632,13.8456689181363,10.7049475828261,11.5117654063349,9.4753379579635,12.7964655882559,7.65073956634426,8.77165525528312,9.82797690768418,11.5144892695058,8.31225482472303,11.6689513853998,83933,"histone deacetylase 10","protein_coding","hsa04613,hsa05203,hsa05034","Neutrophil extracellular trap formation|Viral carcinogenesis|Alcoholism","GO:0000118,GO:0000122,GO:0004407,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006281,GO:0006325,GO:0006338,GO:0006355,GO:0006476,GO:0008270,GO:0016236,GO:0019213,GO:0019899,GO:0032425,GO:0033558,GO:0034983,GO:0035825,GO:0042826,GO:0043231,GO:0045892,GO:0047609,GO:0047611,GO:0106047,GO:0106048","histone deacetylase complex|negative regulation of transcription by RNA polymerase II|histone deacetylase activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|DNA repair|chromatin organization|chromatin remodeling|regulation of DNA-templated transcription|protein deacetylation|zinc ion binding|macroautophagy|deacetylase activity|enzyme binding|positive regulation of mismatch repair|protein lysine deacetylase activity|peptidyl-lysine deacetylation|homologous recombination|histone deacetylase binding|intracellular membrane-bounded organelle|negative regulation of DNA-templated transcription|acetylputrescine deacetylase activity|acetylspermidine deacetylase activity|polyamine deacetylation|spermidine deacetylation","WP2064,WP3996,WP2858","Neural crest differentiation|Ethanol effects on histone modifications|Ectoderm differentiation","R-HSA-157118,R-HSA-162582,R-HSA-1643685,R-HSA-1980143,R-HSA-2122947,R-HSA-212436,R-HSA-2644602,R-HSA-2644603,R-HSA-2644606,R-HSA-2894858,R-HSA-2894862,R-HSA-3214815,R-HSA-3247509,R-HSA-350054,R-HSA-4839726,R-HSA-5663202,R-HSA-73857,R-HSA-74160","Signaling by NOTCH|Signal Transduction|Disease|Signaling by NOTCH1|NOTCH1 Intracellular Domain Regulates Transcription|Generic Transcription Pathway|Signaling by NOTCH1 PEST Domain Mutants in Cancer|Signaling by NOTCH1 in Cancer|Constitutive Signaling by NOTCH1 PEST Domain Mutants|Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer|Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants|HDACs deacetylate histones|Chromatin modifying enzymes|Notch-HLH transcription pathway|Chromatin organization|Diseases of signal transduction by growth factor receptors and second messengers|RNA Polymerase II Transcription|Gene expression (Transcription)"]
["HEATR3",6.34097221951588,6.00975696068549,5.83609066335493,5.12486488683661,5.09422756248771,5.12437864280317,6.45004930973004,4.74541438921848,5.01588871468909,3.72761074316922,4.89748797408507,5.17661016041696,4.59675400232077,4.31655694308187,5.18035614427041,4.77645230569972,8.68977193749044,7.58158639496212,9.31703437885574,7.00762357823693,7.37019114695789,8.2949819633865,10.326935649738,9.70487784395702,7.92705486534957,8.27571365386568,11.2960207806567,8.09749445266845,55027,"HEAT repeat containing 3","protein_coding",null,null,"GO:0006606,GO:0042273,GO:0043249,GO:0051082","protein import into nucleus|ribosomal large subunit biogenesis|erythrocyte maturation|unfolded protein binding"]
["HECTD3",19.3668194505568,21.699080508038,23.1199610944851,23.4742569558937,18.9317615979753,22.4991119774627,22.8571958310358,23.5312611245083,19.186493550636,25.7097388819504,23.3427111059131,21.3011848820044,17.2278277406617,21.6923937738029,20.4984376401442,21.3532828687947,18.1014002821127,20.4219181035221,22.0191658344151,19.2503328370588,18.6683293079383,20.3601452975882,17.3146285955281,17.7570552554526,18.0568421519616,18.9643429614865,18.1246764834239,21.0877798790562,79654,"HECT domain E3 ubiquitin protein ligase 3","protein_coding",null,null,"GO:0004842,GO:0005515,GO:0016567,GO:0019905,GO:0043161,GO:0048471","ubiquitin-protein transferase activity|protein binding|protein ubiquitination|syntaxin binding|proteasome-mediated ubiquitin-dependent protein catabolic process|perinuclear region of cytoplasm",null,null,"R-HSA-1280218,R-HSA-168256,R-HSA-983168,R-HSA-983169","Adaptive Immune System|Immune System|Antigen processing: Ubiquitination & Proteasome degradation|Class I MHC mediated antigen processing & presentation"]
["HERC6",1.50939324361016,1.49703739331363,1.6774745957302,1.75072503898854,1.8026745495645,1.66574454407453,1.89572151122739,1.58763539976776,1.6674742033366,1.42267635531895,1.6075501158759,1.58347138094427,1.70532754863276,1.75880425854667,1.96161888167336,1.63907663274356,1.1845184746495,1.25334857137815,1.77655556039581,1.23436515447208,1.33332010867302,1.21400561582903,1.34364026432848,1.22256136539575,1.33017556461212,1.43419507072131,1.54175723750924,1.2492089062066,55008,"HECT and RLD domain containing E3 ubiquitin protein ligase family member 6","protein_coding",null,null,"GO:0002244,GO:0005654,GO:0005737,GO:0005829,GO:0006511,GO:0009617,GO:0016567,GO:0061630","hematopoietic progenitor cell differentiation|nucleoplasm|cytoplasm|cytosol|ubiquitin-dependent protein catabolic process|response to bacterium|protein ubiquitination|ubiquitin protein ligase activity",null,null,"R-HSA-1280218,R-HSA-168256,R-HSA-983168,R-HSA-983169","Adaptive Immune System|Immune System|Antigen processing: Ubiquitination & Proteasome degradation|Class I MHC mediated antigen processing & presentation"]
["HHATL",0,0,0,0.0128237000426501,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,57467,"hedgehog acyltransferase like","protein_coding","hsa04340","Hedgehog signaling pathway","GO:0005515,GO:0005783,GO:0005789,GO:0016746,GO:0048471,GO:0060262","protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|acyltransferase activity|perinuclear region of cytoplasm|negative regulation of N-terminal protein palmitoylation"]
["HIGD1B",0,0.025781632036272,0,0,0.0132430763300074,0,0.0126444974269901,0.013289683569652,0.0545285036239682,0,0.0637274057717957,0.0136350890985793,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.0127410564391468,51751,"HIG1 hypoxia inducible domain family member 1B","protein_coding",null,null,"GO:0005739,GO:0016020,GO:0097250","mitochondrion|membrane|mitochondrial respirasome assembly"]
["HIP1R",4.14604576501001,5.43503048099741,6.04434794429927,5.61724135041884,5.03826438343717,5.83352625723868,5.48177578392286,5.51727636551687,4.48580437620643,6.55164726399597,6.39298942884756,5.3266006270661,4.7059855530553,6.51170008301098,5.07387169441188,5.78074451321269,3.51616716799098,4.00260994064308,2.80037218542172,3.67648639421805,3.69560767255215,3.96288793803627,2.71808316808497,3.09087120628995,3.82243196046402,3.52757376561034,2.51255335574907,4.11021031173224,9026,"huntingtin interacting protein 1 related","protein_coding",null,null,"GO:0005515,GO:0005546,GO:0005547,GO:0005739,GO:0005829,GO:0005856,GO:0005886,GO:0005905,GO:0005938,GO:0006897,GO:0006898,GO:0006919,GO:0007015,GO:0014069,GO:0016324,GO:0017124,GO:0030100,GO:0030136,GO:0030276,GO:0030665,GO:0030837,GO:0032051,GO:0032092,GO:0032587,GO:0032839,GO:0032956,GO:0034316,GO:0035091,GO:0035615,GO:0042802,GO:0042803,GO:0043025,GO:0043065,GO:0043066,GO:0043197,GO:0043231,GO:0043325,GO:0045742,GO:0046982,GO:0048268,GO:0048471,GO:0050821,GO:0051015,GO:0055123,GO:0060453,GO:0080025,GO:0097060,GO:0098978,GO:0099173,GO:1901030,GO:1905445,GO:2000369,GO:2000588","protein binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylinositol-3,4,5-trisphosphate binding|mitochondrion|cytosol|cytoskeleton|plasma membrane|clathrin-coated pit|cell cortex|endocytosis|receptor-mediated endocytosis|activation of cysteine-type endopeptidase activity involved in apoptotic process|actin filament organization|postsynaptic density|apical plasma membrane|SH3 domain binding|regulation of endocytosis|clathrin-coated vesicle|clathrin binding|clathrin-coated vesicle membrane|negative regulation of actin filament polymerization|clathrin light chain binding|positive regulation of protein binding|ruffle membrane|dendrite cytoplasm|regulation of actin cytoskeleton organization|negative regulation of Arp2/3 complex-mediated actin nucleation|phosphatidylinositol binding|clathrin adaptor activity|identical protein binding|protein homodimerization activity|neuronal cell body|positive regulation of apoptotic process|negative regulation of apoptotic process|dendritic spine|intracellular membrane-bounded organelle|phosphatidylinositol-3,4-bisphosphate binding|positive regulation of epidermal growth factor receptor signaling pathway|protein heterodimerization activity|clathrin coat assembly|perinuclear region of cytoplasm|protein stabilization|actin filament binding|digestive system development|regulation of gastric acid secretion|phosphatidylinositol-3,5-bisphosphate binding|synaptic membrane|glutamatergic synapse|postsynapse organization|positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway|positive regulation of clathrin coat assembly|regulation of clathrin-dependent endocytosis|positive regulation of platelet-derived growth factor receptor-beta signaling pathway","WP5323,WP5380","Fatty Acids and Lipoproteins Transport in Hepatocytes|5q35 copy number variation","R-HSA-199991,R-HSA-199992,R-HSA-432722,R-HSA-5653656,R-HSA-8856828","Membrane Trafficking|trans-Golgi Network Vesicle Budding|Golgi Associated Vesicle Biogenesis|Vesicle-mediated transport|Clathrin-mediated endocytosis"]
["HLA-G",0,0,0,0,0.01535887977865,0,0,0,0,0.0151383617168775,0.0147817854320818,0,0.0149475928135921,0,0,0,0,0,0,0,0,0.0448213576159512,0.0155170371951659,0,0.0155831007078774,0,0,0.014776653794439,3135,"major histocompatibility complex%2C class I%2C G","protein_coding","hsa04514,hsa04144,hsa04145,hsa04218,hsa04650,hsa04612,hsa05203,hsa05166,hsa05170,hsa05168,hsa05163,hsa05167,hsa05169,hsa05165,hsa05320,hsa05330,hsa05332,hsa05416,hsa04940","Cell adhesion molecules|Endocytosis|Phagosome|Cellular senescence|Natural killer cell mediated cytotoxicity|Antigen processing and presentation|Viral carcinogenesis|Human T-cell leukemia virus 1 infection|Human immunodeficiency virus 1 infection|Herpes simplex virus 1 infection|Human cytomegalovirus infection|Kaposi sarcoma-associated herpesvirus infection|Epstein-Barr virus infection|Human papillomavirus infection|Autoimmune thyroid disease|Allograft rejection|Graft-versus-host disease|Viral myocarditis|Type I diabetes mellitus","GO:0000139,GO:0001915,GO:0001916,GO:0002451,GO:0002476,GO:0002486,GO:0002645,GO:0002666,GO:0002729,GO:0002767,GO:0005102,GO:0005515,GO:0005615,GO:0005769,GO:0005886,GO:0006955,GO:0006968,GO:0009897,GO:0012507,GO:0016020,GO:0016525,GO:0030670,GO:0031527,GO:0031901,GO:0032735,GO:0033106,GO:0042130,GO:0042270,GO:0042605,GO:0042610,GO:0042612,GO:0042802,GO:0042803,GO:0045591,GO:0045953,GO:0050777,GO:0051898,GO:0055038,GO:0060907,GO:0070207,GO:0070317,GO:0098553,GO:2000353,GO:2000774,GO:2001199","Golgi membrane|negative regulation of T cell mediated cytotoxicity|positive regulation of T cell mediated cytotoxicity|peripheral B cell tolerance induction|antigen processing and presentation of endogenous peptide antigen via MHC class Ib|antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent|positive regulation of tolerance induction|positive regulation of T cell tolerance induction|positive regulation of natural killer cell cytokine production|immune response-inhibiting cell surface receptor signaling pathway|signaling receptor binding|protein binding|extracellular space|early endosome|plasma membrane|immune response|cellular defense response|external side of plasma membrane|ER to Golgi transport vesicle membrane|membrane|negative regulation of angiogenesis|phagocytic vesicle membrane|filopodium membrane|early endosome membrane|positive regulation of interleukin-12 production|cis-Golgi network membrane|negative regulation of T cell proliferation|protection from natural killer cell mediated cytotoxicity|peptide antigen binding|CD8 receptor binding|MHC class I protein complex|identical protein binding|protein homodimerization activity|positive regulation of regulatory T cell differentiation|negative regulation of natural killer cell mediated cytotoxicity|negative regulation of immune response|negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction|recycling endosome membrane|positive regulation of macrophage cytokine production|protein homotrimerization|negative regulation of G0 to G1 transition|lumenal side of endoplasmic reticulum membrane|positive regulation of endothelial cell apoptotic process|positive regulation of cellular senescence|negative regulation of dendritic cell differentiation","WP183,WP2328,WP5362,WP4217","Proteasome degradation|Allograft rejection|TAR syndrome|Ebola virus infection in host","R-HSA-1236974,R-HSA-1236974,R-HSA-1236975,R-HSA-1236975,R-HSA-1236977,R-HSA-1280215,R-HSA-1280218,R-HSA-1280218,R-HSA-1643685,R-HSA-168256,R-HSA-168256,R-HSA-198933,R-HSA-5663205,R-HSA-877300,R-HSA-909733,R-HSA-913531,R-HSA-9679506,R-HSA-9694516,R-HSA-9705671,R-HSA-9705683,R-HSA-9824446,R-HSA-983169,R-HSA-983169,R-HSA-983170,R-HSA-983170","ER-Phagosome pathway|ER-Phagosome pathway|Antigen processing-Cross presentation|Antigen processing-Cross presentation|Endosomal/Vacuolar pathway|Cytokine Signaling in Immune system|Adaptive Immune System|Adaptive Immune System|Disease|Immune System|Immune System|Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell|Infectious disease|Interferon gamma signaling|Interferon alpha/beta signaling|Interferon Signaling|SARS-CoV Infections|SARS-CoV-2 Infection|SARS-CoV-2 activates/modulates innate and adaptive immune responses|SARS-CoV-2-host interactions|Viral Infection Pathways|Class I MHC mediated antigen processing & presentation|Class I MHC mediated antigen processing & presentation|Antigen Presentation: Folding, assembly and peptide loading of class I MHC|Antigen Presentation: Folding, assembly and peptide loading of class I MHC"]
["HMGCR",13.8763305077713,13.8393070770409,15.2406811608507,11.0320742858288,15.3509155766629,14.4360371274682,15.4350500016195,13.3030760288828,14.3286942907006,9.67343715193581,10.9033913965393,12.4388270073553,16.5360005571654,12.8573696143828,17.4435008896299,16.5322446895088,12.4264813099955,10.1982261765252,12.8495016759303,12.110142848039,10.8167924887121,10.5377444059589,15.0973879550583,14.2565679205734,11.8177254614796,9.51799248668306,14.8968667573742,9.99004937137349,3156,"3-hydroxy-3-methylglutaryl-CoA reductase","protein_coding","hsa00900,hsa04152,hsa04976","Terpenoid backbone biosynthesis|AMPK signaling pathway|Bile secretion","GO:0004420,GO:0005515,GO:0005778,GO:0005783,GO:0005789,GO:0006695,GO:0008299,GO:0008542,GO:0015936,GO:0016126,GO:0030695,GO:0042177,GO:0050709,GO:0060291,GO:0070372,GO:0070402,GO:0120225,GO:1900222","hydroxymethylglutaryl-CoA reductase (NADPH) activity|protein binding|peroxisomal membrane|endoplasmic reticulum|endoplasmic reticulum membrane|cholesterol biosynthetic process|isoprenoid biosynthetic process|visual learning|coenzyme A metabolic process|sterol biosynthetic process|GTPase regulator activity|negative regulation of protein catabolic process|negative regulation of protein secretion|long-term synaptic potentiation|regulation of ERK1 and ERK2 cascade|NADPH binding|coenzyme A binding|negative regulation of amyloid-beta clearance","WP4190,WP2011,WP197,WP5323,WP4718,WP1982,WP5238,WP5193,WP3963,WP430,WP5220,WP4313,WP4189,WP5304,WP1403,WP5329,WP5333,WP1471","Mevalonate arm of cholesterol biosynthesis pathway|SREBF and miR33 in cholesterol and lipid homeostasis|Cholesterol biosynthesis pathway|Fatty Acids and Lipoproteins Transport in Hepatocytes|Cholesterol metabolism with Bloch and Kandutsch-Russell pathways|Sterol regulatory element-binding proteins (SREBP) signaling|Cholestasis|Cholesterol synthesis disorders|Mevalonate pathway|Statin inhibition of cholesterol production|Metabolic reprogramming in pancreatic cancer|Ferroptosis|Mevalonate arm of cholesterol biosynthesis pathway with inhibitors|Cholesterol metabolism|AMP-activated protein kinase signaling|Cholesterol biosynthesis pathway in hepatocytes|Enterocyte cholesterol metabolism|Target of rapamycin signaling","R-HSA-1266738,R-HSA-1430728,R-HSA-1655829,R-HSA-191273,R-HSA-1989781,R-HSA-2426168,R-HSA-400206,R-HSA-556833,R-HSA-8957322,R-HSA-9619665,R-HSA-9675108","Developmental Biology|Metabolism|Regulation of cholesterol biosynthesis by SREBP (SREBF)|Cholesterol biosynthesis|PPARA activates gene expression|Activation of gene expression by SREBF (SREBP)|Regulation of lipid metabolism by PPARalpha|Metabolism of lipids|Metabolism of steroids|EGR2 and SOX10-mediated initiation of Schwann cell myelination|Nervous system development"]
["HMMR",13.2189132403596,8.93483572484623,5.10176906321323,8.03178607127515,9.99121610428391,7.11725607588013,3.41891949825471,5.56534141038594,6.62574202278263,3.91672483644645,2.76538484856455,4.62194257280378,6.34928245737964,1.71272866656361,3.01727253451947,2.14400611638865,15.0207263344524,11.6934595857364,16.0500490778879,14.5508568756452,20.0605667456908,15.0712805729825,26.7970125876486,19.8476643626307,17.2170787196025,15.2949166584206,21.6827523965928,14.2338469397023,3161,"hyaluronan mediated motility receptor","protein_coding","hsa04512","ECM-receptor interaction","GO:0005515,GO:0005540,GO:0005813,GO:0005819,GO:0005829,GO:0005886,GO:0006898,GO:0009986,GO:0015630,GO:0016020,GO:0030214,GO:0038024","protein binding|hyaluronic acid binding|centrosome|spindle|cytosol|plasma membrane|receptor-mediated endocytosis|cell surface|microtubule cytoskeleton|membrane|hyaluronan catabolic process|cargo receptor activity",null,null,"R-HSA-1430728,R-HSA-1630316,R-HSA-1640170,R-HSA-2142845,R-HSA-2160916,R-HSA-453274,R-HSA-69275,R-HSA-69278,R-HSA-71387,R-HSA-8854518","Metabolism|Glycosaminoglycan metabolism|Cell Cycle|Hyaluronan metabolism|Hyaluronan uptake and degradation|Mitotic G2-G2/M phases|G2/M Transition|Cell Cycle, Mitotic|Metabolism of carbohydrates|AURKA Activation by TPX2"]
["HNRNPM",80.1036255667189,75.529584760507,98.550605164914,89.3628697257823,68.6649918229101,74.8742978516941,95.3146127131502,82.7638394477523,84.7494748665919,88.8645486470897,106.447332342779,100.342981599079,76.136965332858,79.7453310067344,92.1146612944566,75.1272489270408,84.2212320232609,99.0348401068031,109.401764242717,93.9743132222754,79.2081592457796,94.4189911528522,95.6019208816547,90.2510999098306,85.1263399060091,92.0721304205599,96.3299691734197,94.9919498027672,4670,"heterogeneous nuclear ribonucleoprotein M","protein_coding","hsa03040","Spliceosome","GO:0000380,GO:0000398,GO:0003723,GO:0003729,GO:0005515,GO:0005634,GO:0005654,GO:0005681,GO:0005730,GO:0016020,GO:0016363,GO:0019904,GO:0042382,GO:0045202,GO:0062023,GO:0070062,GO:0071013","alternative mRNA splicing, via spliceosome|mRNA splicing, via spliceosome|RNA binding|mRNA binding|protein binding|nucleus|nucleoplasm|spliceosomal complex|nucleolus|membrane|nuclear matrix|protein domain specific binding|paraspeckles|synapse|collagen-containing extracellular matrix|extracellular exosome|catalytic step 2 spliceosome","WP411","mRNA processing","R-HSA-162582,R-HSA-190236,R-HSA-5654738,R-HSA-6803529,R-HSA-72163,R-HSA-72172,R-HSA-72203,R-HSA-8953854,R-HSA-9006934","Signal Transduction|Signaling by FGFR|Signaling by FGFR2|FGFR2 alternative splicing|mRNA Splicing - Major Pathway|mRNA Splicing|Processing of Capped Intron-Containing Pre-mRNA|Metabolism of RNA|Signaling by Receptor Tyrosine Kinases"]
["HOXA7",0,0,0,0,0,0,0,0.0524467869445195,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.0132564571994096,0,0,0,3204,"homeobox A7","protein_coding",null,null,"GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0001525,GO:0001953,GO:0002686,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0009952,GO:0031965,GO:0043565,GO:0045617,GO:0045656,GO:0045892,GO:0045944,GO:0048704,GO:0048863,GO:0140297,GO:1990837","negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|angiogenesis|negative regulation of cell-matrix adhesion|negative regulation of leukocyte migration|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|anterior/posterior pattern specification|nuclear membrane|sequence-specific DNA binding|negative regulation of keratinocyte differentiation|negative regulation of monocyte differentiation|negative regulation of DNA-templated transcription|positive regulation of transcription by RNA polymerase II|embryonic skeletal system morphogenesis|stem cell differentiation|DNA-binding transcription factor binding|sequence-specific double-stranded DNA binding",{"$nulls":4},"Homeobox"]
["HPF1",22.2787798613645,20.13654652333,20.3541904456057,20.2823689464042,19.9503133170842,20.0466029636634,22.3370870171596,20.0205257821174,23.1452646112211,14.3902826415756,23.1200617399396,23.395626345157,24.1172526287461,18.4292115986118,24.9248169553109,21.880336187319,22.400101368937,24.2442552847389,30.5682199444928,25.4100563706786,24.7731260710585,27.3085916369292,34.1181493364781,27.5266451410398,22.6371449386761,28.0776860532138,30.35388459609,27.3843232666993,54969,"histone PARylation factor 1","protein_coding",null,null,"GO:0000785,GO:0003682,GO:0005515,GO:0005634,GO:0006281,GO:0006302,GO:0006974,GO:0010835,GO:0042393,GO:0072572,GO:0090734,GO:0140768,GO:0140861","chromatin|chromatin binding|protein binding|nucleus|DNA repair|double-strand break repair|DNA damage response|regulation of protein ADP-ribosylation|histone binding|poly-ADP-D-ribose binding|site of DNA damage|protein ADP-ribosyltransferase-substrate adaptor activity|DNA repair-dependent chromatin remodeling"]
["HPN",0,0,0,0,0,0,0,0,0,0,0.00952320135838481,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,3249,"hepsin","protein_coding","hsa05203","Viral carcinogenesis","GO:0004252,GO:0005515,GO:0005789,GO:0005886,GO:0005911,GO:0006508,GO:0008233,GO:0008236,GO:0008360,GO:0009986,GO:0010628,GO:0010719,GO:0010756,GO:0016020,GO:0016324,GO:0030307,GO:0031965,GO:0034769,GO:0043025,GO:0043066,GO:0043923,GO:0050680,GO:0050910,GO:0070008,GO:0070062,GO:0071805,GO:0090103,GO:0097066,GO:0097195,GO:2000347,GO:2000611","serine-type endopeptidase activity|protein binding|endoplasmic reticulum membrane|plasma membrane|cell-cell junction|proteolysis|peptidase activity|serine-type peptidase activity|regulation of cell shape|cell surface|positive regulation of gene expression|negative regulation of epithelial to mesenchymal transition|positive regulation of plasminogen activation|membrane|apical plasma membrane|positive regulation of cell growth|nuclear membrane|basement membrane disassembly|neuronal cell body|negative regulation of apoptotic process|positive regulation by host of viral transcription|negative regulation of epithelial cell proliferation|detection of mechanical stimulus involved in sensory perception of sound|serine-type exopeptidase activity|extracellular exosome|potassium ion transmembrane transport|cochlea morphogenesis|response to thyroid hormone|pilomotor reflex|positive regulation of hepatocyte proliferation|positive regulation of thyroid hormone generation",null,null,"R-HSA-162582,R-HSA-6806834,R-HSA-6806942,R-HSA-8852405,R-HSA-9006934","Signal Transduction|Signaling by MET|MET Receptor Activation|Signaling by MST1|Signaling by Receptor Tyrosine Kinases"]
["HS3ST5",0,0.00559699477408263,0.00552444001203883,0.00846515366273175,0.00287497040170103,0.0165771184132582,0.00823507052465077,0.0288508847631934,0.035513161004608,0.0793433889592296,0.102377013162273,0.121363008175076,0.10632335992816,0.0476850761429969,0.0519879347496829,0.0474237038530339,0.118806402517072,0.130670001678717,0.100611202096447,0.0848777611130117,0.136071909073054,0.145425622942244,0.107469285660255,0.0776094820953082,0.0612557707917711,0.106232658127441,0.113883581728634,0.0912775290871295,222537,"heparan sulfate-glucosamine 3-sulfotransferase 5","protein_coding","hsa00534","Glycosaminoglycan biosynthesis - heparan sulfate / heparin","GO:0000139,GO:0005515,GO:0006477,GO:0008467,GO:0015015,GO:0016020,GO:0046596,GO:0050656,GO:0050819","Golgi membrane|protein binding|protein sulfation|[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity|heparan sulfate proteoglycan biosynthetic process, enzymatic modification|membrane|regulation of viral entry into host cell|3'-phosphoadenosine 5'-phosphosulfate binding|negative regulation of coagulation","WP702","Metapathway biotransformation Phase I and II","R-HSA-1430728,R-HSA-1630316,R-HSA-1638091,R-HSA-2022928,R-HSA-71387","Metabolism|Glycosaminoglycan metabolism|Heparan sulfate/heparin (HS-GAG) metabolism|HS-GAG biosynthesis|Metabolism of carbohydrates"]
["HSF2BP",0.0527331260159477,0.0569976726393218,0.0382559856675749,0.02068941966689,0.0468441736090785,0.0630242997401094,0.0648539263814885,0.0352567765694973,0.0892076330961829,0.0554059192838948,0.0653718743077174,0.0675231533058938,0.0478692473040656,0.0548449959877567,0.017833277167146,0.0659077908293847,0.0437861100610735,0.0754059793165976,0.0841822285811914,0.0530142601467203,0.05655937670933,0.0751871697870282,0.0378612396083367,0.0562023494739632,0.0308932269502159,0.0455508678530668,0.0579873608281695,0.0450683998887836,11077,"heat shock transcription factor 2 binding protein","protein_coding",null,null,"GO:0005515,GO:0005654,GO:0005694,GO:0005829,GO:0006366,GO:0007141,GO:0007144,GO:0007283,GO:1990918","protein binding|nucleoplasm|chromosome|cytosol|transcription by RNA polymerase II|male meiosis I|female meiosis I|spermatogenesis|double-strand break repair involved in meiotic recombination","WP5316","Primary ovarian insufficiency"]
["HSPA6",0.0915710071685541,0.0653244154396752,0.934925262623371,0.318354479530148,0.0447396667862163,0.193477145098436,0.288342864255479,0.258158451915443,0.345405075503416,0.54019202839822,1.44246374103895,0.529736238634998,0.283020451617016,0.196428925120481,0.510963146552163,0.293028383088308,0.0220099941332811,0.0423637139200428,0.296211572169786,0.0550353890528954,0.0756257707568896,0.065281213003275,0.0678005574260119,0.0447311834525258,0.0113482028509596,0.141389506972031,0.099688029534817,0.0430436709256272,3310,"heat shock protein family A (Hsp70) member 6","protein_coding","hsa03040,hsa04141,hsa04010,hsa04144,hsa04612,hsa04915,hsa04213,hsa05162,hsa05134,hsa05145,hsa05020,hsa05417","Spliceosome|Protein processing in endoplasmic reticulum|MAPK signaling pathway|Endocytosis|Antigen processing and presentation|Estrogen signaling pathway|Longevity regulating pathway - multiple species|Measles|Legionellosis|Toxoplasmosis|Prion disease|Lipid and atherosclerosis","GO:0005515,GO:0005524,GO:0005576,GO:0005634,GO:0005737,GO:0005814,GO:0005829,GO:0006986,GO:0016887,GO:0019899,GO:0031072,GO:0031625,GO:0034605,GO:0034774,GO:0042026,GO:0044183,GO:0051082,GO:0051085,GO:0070062,GO:0070370,GO:0072562,GO:0140662,GO:1904813","protein binding|ATP binding|extracellular region|nucleus|cytoplasm|centriole|cytosol|response to unfolded protein|ATP hydrolysis activity|enzyme binding|heat shock protein binding|ubiquitin protein ligase binding|cellular response to heat|secretory granule lumen|protein refolding|protein folding chaperone|unfolded protein binding|chaperone cofactor-dependent protein refolding|extracellular exosome|cellular heat acclimation|blood microparticle|ATP-dependent protein folding chaperone|ficolin-1-rich granule lumen","WP4630,WP382,WP2359","Measles virus infection|MAPK signaling pathway|Parkin-ubiquitin proteasomal system pathway","R-HSA-168249,R-HSA-168256,R-HSA-2262752,R-HSA-3371453,R-HSA-3371556,R-HSA-6798695,R-HSA-8953897","Innate Immune System|Immune System|Cellular responses to stress|Regulation of HSF1-mediated heat shock response|Cellular response to heat stress|Neutrophil degranulation|Cellular responses to stimuli"]
["HSPB7",0.432122534305424,0.32294446220702,0.0772746860920607,0.286154503547137,0.643431543704057,0.415446630585095,0.163186408969014,0.252225005916391,0.0517448443263706,0.009909271123834,0,0,0.0097843975859964,0,0,0.0195103715627075,0.0494594810914858,0.0095197086146661,0,0.049468832526553,0.0485547137765744,0.0880175133336141,0,0.0201034230974615,0.0102003884404617,0,0.00995611999807015,0,27129,"heat shock protein family B (small) member 7","protein_coding",null,null,"GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006986,GO:0007507,GO:0008016,GO:0015030,GO:0015629,GO:0016235,GO:0031005","protein binding|nucleus|nucleoplasm|cytoplasm|response to unfolded protein|heart development|regulation of heart contraction|Cajal body|actin cytoskeleton|aggresome|filamin binding","WP2895","Differentiation of white and brown adipocyte"]
["HUNK",0.00350992385875561,0.0200311195781816,0,0.0269297700895654,0,0.0131839894880444,0.00327472726331816,0,0.201238933638025,0.152122794986982,0.23766339390019,0.243657976950277,0.203612294556503,0.090349632550534,0.186059944600232,0.123133816359952,0.0506186876795675,0.0617045696403748,0.0291955183786208,0.0371273894118556,0.0331284765871419,0.0867441118096903,0.0796965536670992,0.0651528907416428,0.0591569402523655,0.0400207078027804,0.0543438216561329,0.079193628929572,30811,"hormonally up-regulated Neu-associated kinase","protein_coding",null,null,"GO:0004674,GO:0005515,GO:0005524,GO:0005737,GO:0007165,GO:0016310,GO:0035556,GO:0106310","protein serine/threonine kinase activity|protein binding|ATP binding|cytoplasm|signal transduction|phosphorylation|intracellular signal transduction|protein serine kinase activity"]
["ICAM4",0,0.0198758395814515,0.0392363716203874,0.0200407591364207,0.0204189758297557,0.0196226820287173,0.0779842027357626,0.0204908376899518,0,0.020125806468562,0,0,0,0,0.019433433626136,0.0198128579435247,0,0,0,0,0.0197230000146705,0,0,0.0204151040757167,0,0,0,0.0196449312073356,3386,"intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)","protein_coding",null,null,"GO:0005178,GO:0005576,GO:0005886,GO:0007155,GO:0016020,GO:0098609","integrin binding|extracellular region|plasma membrane|cell adhesion|membrane|cell-cell adhesion",null,null,"R-HSA-1280218,R-HSA-1474244,R-HSA-168256,R-HSA-198933,R-HSA-216083","Adaptive Immune System|Extracellular matrix organization|Immune System|Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell|Integrin cell surface interactions"]
["IER5",23.048494435847,19.9393798160573,20.379703915423,20.1848274358542,20.5218726920065,20.0951491287422,20.4384139431363,19.88937965721,12.669690029097,11.3094480672064,12.111159096918,12.3883953498133,12.7229775513026,12.9996032974928,12.8657564718768,11.9792566782033,16.1447707918598,17.4134301502159,15.1580407155385,16.6414518576137,15.9766159271421,16.5350195470988,12.6945690203709,14.3306158088655,15.4522894613972,14.900926045417,13.7038016923687,15.9797322949344,51278,"immediate early response 5","protein_coding",null,null,"GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0034605,GO:0042127,GO:0042802,GO:0045944,GO:1900036","protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cellular response to heat|regulation of cell population proliferation|identical protein binding|positive regulation of transcription by RNA polymerase II|positive regulation of cellular response to heat","WP3888","VEGFA-VEGFR2 signaling"]
["IFNA5",0,0,0,0,0,0,0,0,0,0,0.0256586660081177,0,0,0,0,0,0,0,0,0.0262365063197507,0,0,0,0,0,0,0,0,3442,"interferon alpha 5","protein_coding","hsa04630,hsa04151,hsa04060,hsa04217,hsa04620,hsa04621,hsa04622,hsa04623,hsa04650,hsa05200,hsa05170,hsa05161,hsa05160,hsa05171,hsa05164,hsa05162,hsa05168,hsa05163,hsa05167,hsa05169,hsa05165,hsa05152,hsa05320,hsa05417,hsa04936","JAK-STAT signaling pathway|PI3K-Akt signaling pathway|Cytokine-cytokine receptor interaction|Necroptosis|Toll-like receptor signaling pathway|NOD-like receptor signaling pathway|RIG-I-like receptor signaling pathway|Cytosolic DNA-sensing pathway|Natural killer cell mediated cytotoxicity|Pathways in cancer|Human immunodeficiency virus 1 infection|Hepatitis B|Hepatitis C|Coronavirus disease - COVID-19|Influenza A|Measles|Herpes simplex virus 1 infection|Human cytomegalovirus infection|Kaposi sarcoma-associated herpesvirus infection|Epstein-Barr virus infection|Human papillomavirus infection|Tuberculosis|Autoimmune thyroid disease|Lipid and atherosclerosis|Alcoholic liver disease","GO:0002250,GO:0002286,GO:0002323,GO:0005125,GO:0005126,GO:0005132,GO:0005576,GO:0005615,GO:0006959,GO:0019221,GO:0030183,GO:0033141,GO:0042100,GO:0043330,GO:0051607,GO:0060337,GO:0098586","adaptive immune response|T cell activation involved in immune response|natural killer cell activation involved in immune response|cytokine activity|cytokine receptor binding|type I interferon receptor binding|extracellular region|extracellular space|humoral immune response|cytokine-mediated signaling pathway|B cell differentiation|positive regulation of peptidyl-serine phosphorylation of STAT protein|B cell proliferation|response to exogenous dsRNA|defense response to virus|type I interferon-mediated signaling pathway|cellular response to virus","WP4630,WP4666,WP5095,WP4912,WP75,WP4558,WP4655,WP4172","Measles virus infection|Hepatitis B infection|Overview of proinflammatory and profibrotic mediators|SARS coronavirus and innate immunity|Toll-like receptor signaling pathway|Overview of interferons-mediated signaling pathway|Cytosolic DNA-sensing pathway|PI3K-Akt signaling pathway","R-HSA-109582,R-HSA-1280215,R-HSA-1280215,R-HSA-1643685,R-HSA-168249,R-HSA-168256,R-HSA-168256,R-HSA-168928,R-HSA-5663205,R-HSA-909733,R-HSA-909733,R-HSA-912694,R-HSA-912694,R-HSA-913531,R-HSA-913531,R-HSA-933541,R-HSA-9679506,R-HSA-9694516,R-HSA-9705671,R-HSA-9705683,R-HSA-9824446,R-HSA-983231","Hemostasis|Cytokine Signaling in Immune system|Cytokine Signaling in Immune system|Disease|Innate Immune System|Immune System|Immune System|DDX58/IFIH1-mediated induction of interferon-alpha/beta|Infectious disease|Interferon alpha/beta signaling|Interferon alpha/beta signaling|Regulation of IFNA/IFNB signaling|Regulation of IFNA/IFNB signaling|Interferon Signaling|Interferon Signaling|TRAF6 mediated IRF7 activation|SARS-CoV Infections|SARS-CoV-2 Infection|SARS-CoV-2 activates/modulates innate and adaptive immune responses|SARS-CoV-2-host interactions|Viral Infection Pathways|Factors involved in megakaryocyte development and platelet production"]
["IFNGR2",28.8303027832989,27.8596349603324,30.0546832234486,31.696822176605,29.1968140838109,32.1313481630444,32.2099138017963,31.3222210233067,36.2314368137156,33.227644878964,38.4307354217501,36.2511707947513,35.824157793744,39.689751229234,36.5459017688253,35.8066077559504,43.1077331970854,38.6938900532875,39.9247969152561,38.4347953717147,40.8617957934025,40.2661201211215,37.4100025836976,39.7047440841547,40.338767445895,42.3341042048475,38.2321973291874,42.5283984722969,3460,"interferon gamma receptor 2","protein_coding","hsa04630,hsa04066,hsa04060,hsa04217,hsa04650,hsa04658,hsa04659,hsa04380,hsa05200,hsa05235,hsa05164,hsa05168,hsa05152,hsa05145,hsa05140,hsa05142,hsa05321","JAK-STAT signaling pathway|HIF-1 signaling pathway|Cytokine-cytokine receptor interaction|Necroptosis|Natural killer cell mediated cytotoxicity|Th1 and Th2 cell differentiation|Th17 cell differentiation|Osteoclast differentiation|Pathways in cancer|PD-L1 expression and PD-1 checkpoint pathway in cancer|Influenza A|Herpes simplex virus 1 infection|Tuberculosis|Toxoplasmosis|Leishmaniasis|Chagas disease|Inflammatory bowel disease","GO:0000139,GO:0001774,GO:0004896,GO:0004906,GO:0005515,GO:0005783,GO:0005789,GO:0005886,GO:0007166,GO:0009615,GO:0019221,GO:0030659,GO:0038196,GO:0051607,GO:0060333,GO:0098586","Golgi membrane|microglial cell activation|cytokine receptor activity|type II interferon receptor activity|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|plasma membrane|cell surface receptor signaling pathway|response to virus|cytokine-mediated signaling pathway|cytoplasmic vesicle membrane|type III interferon-mediated signaling pathway|defense response to virus|type II interferon-mediated signaling pathway|cellular response to virus","WP5083,WP4197,WP619,WP5358,WP4538,WP4558,WP4341,WP4494","Neuroinflammation and glutamatergic signaling|Immune response to tuberculosis|Type II interferon signaling|JAK-STAT signaling in the regulation of Beta-cells|Regulatory circuits of the STAT3 signaling pathway|Overview of interferons-mediated signaling pathway|Non-genomic actions of 1,25 dihydroxyvitamin D3|Selective expression of chemokine receptors during T-cell polarization","R-HSA-1280215,R-HSA-1280215,R-HSA-1643685,R-HSA-168256,R-HSA-168256,R-HSA-5663205,R-HSA-877300,R-HSA-877300,R-HSA-877312,R-HSA-877312,R-HSA-913531,R-HSA-913531,R-HSA-9679191,R-HSA-9679506,R-HSA-9732724,R-HSA-9824446","Cytokine Signaling in Immune system|Cytokine Signaling in Immune system|Disease|Immune System|Immune System|Infectious disease|Interferon gamma signaling|Interferon gamma signaling|Regulation of IFNG signaling|Regulation of IFNG signaling|Interferon Signaling|Interferon Signaling|Potential therapeutics for SARS|SARS-CoV Infections|IFNG signaling activates MAPKs|Viral Infection Pathways"]
["IGFALS",0,0.0118047113536245,0,0.0119026608130675,0.0485091690983146,0.0116543553485475,0.0231582922488798,0.0851898086281145,0.0124835628117026,0.0358595170503385,0.0116716215543371,0.0499451053721443,0,0.0118321597774384,0.0346258693062369,0.0117673051322039,0,0.0114832580895143,0,0,0,0,0,0,0.0123043359640929,0.0353774212621263,0,0,3483,"insulin like growth factor binding protein acid labile subunit","protein_coding","hsa04935","Growth hormone synthesis, secretion and action","GO:0005520,GO:0005576,GO:0005615,GO:0007155,GO:0007165,GO:0031012,GO:0042567,GO:0070062","insulin-like growth factor binding|extracellular region|extracellular space|cell adhesion|signal transduction|extracellular matrix|insulin-like growth factor ternary complex|extracellular exosome",null,null,"R-HSA-381426,R-HSA-392499","Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)|Metabolism of proteins"]
["IGSF23",0,0,0.0239653974385889,0,0.0498872704931531,0.0239708899782626,0,0,0,0,0,0.0256820002055628,0,0,0,0.0242032071469194,0.024542394026457,0.0236189740250238,0,0.049094068643776,0,0,0,0,0,0.0242549744259275,0,0.0479961387451951,147710,"immunoglobulin superfamily member 23","protein_coding",null,null,"GO:0005886,GO:0030316","plasma membrane|osteoclast differentiation"]
["IK",61.7516657672446,62.7334708099727,68.9611670748152,67.8545388083537,54.8656272752163,59.9678433356041,71.6343236767822,64.6190667441029,67.3658658556835,69.7234002111186,79.6053849762907,77.246279774197,65.8035406783562,67.4391368671628,72.0622322689607,64.5203378829551,74.7436870850974,75.1129496086768,89.1132023296101,75.0979984452284,71.4798792342712,73.9902579773878,83.327507916335,78.4673011268036,72.9922662288678,74.0969224402722,88.8808179829817,80.7484014870345,3550,"IK cytokine","protein_coding",null,null,"GO:0000228,GO:0000278,GO:0000398,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0007094,GO:0016607,GO:0034501,GO:0042802,GO:0071005,GO:0097431","nuclear chromosome|mitotic cell cycle|mRNA splicing, via spliceosome|protein binding|nucleus|nucleoplasm|cytoplasm|mitotic spindle assembly checkpoint signaling|nuclear speck|protein localization to kinetochore|identical protein binding|U2-type precatalytic spliceosome|mitotic spindle pole",null,null,"R-HSA-72163,R-HSA-72172,R-HSA-72203,R-HSA-8953854","mRNA Splicing - Major Pathway|mRNA Splicing|Processing of Capped Intron-Containing Pre-mRNA|Metabolism of RNA"]
["IL13RA2",1.00733240789398,1.16893110363559,0.43503107099286,0.695585092896397,0.669339521594233,0.416212044824363,0.206763048733272,0.632183691959051,0.101323985153281,0.0582114133283522,0.132627305016549,0.0608076058678797,0.0766371350532453,0.0960368125433346,0.0749450803519148,0.0573062483119885,0.15495825466032,0.167768855854878,0.204819580852507,0.251854773670313,0.342278072003475,0.248951711023326,0.179002592755894,0.275558131246221,0.239686257524752,0.153143515657874,0.175459872611729,0.321983065304089,3598,"interleukin 13 receptor subunit alpha 2","protein_coding","hsa04630,hsa04060","JAK-STAT signaling pathway|Cytokine-cytokine receptor interaction","GO:0002638,GO:0004896,GO:0005515,GO:0005576,GO:0005615,GO:0009897,GO:0016064,GO:0019221,GO:0019955,GO:0043235,GO:0043305","negative regulation of immunoglobulin production|cytokine receptor activity|protein binding|extracellular region|extracellular space|external side of plasma membrane|immunoglobulin mediated immune response|cytokine-mediated signaling pathway|cytokine binding|receptor complex|negative regulation of mast cell degranulation",null,null,"R-HSA-1280215,R-HSA-168256,R-HSA-449147,R-HSA-6785807","Cytokine Signaling in Immune system|Immune System|Signaling by Interleukins|Interleukin-4 and Interleukin-13 signaling"]
["IL23A",0.0438669084381499,0.062587061985531,0.144143383129413,0.0420709182847563,0.128594689114978,0.0411932625175677,0.0409274294260105,0.258094521920629,0.088248326857667,0.0844989108037268,0.0618814369797079,0.0441337546250193,0.0208585204843861,0,0.0611939691888906,0.0831849853446604,0.105438438128309,0.182648274315562,0.0202713661647055,0.0843666989224207,0.0207019284124695,0.250182679613853,0.194878331250925,0.0642851527852105,0.043490671625728,0.270929445825169,0.233470608905111,0.0618599542492995,51561,"interleukin 23 subunit alpha","protein_coding","hsa04630,hsa04060,hsa04625,hsa04659,hsa05200,hsa05133,hsa05152,hsa05323,hsa05321","JAK-STAT signaling pathway|Cytokine-cytokine receptor interaction|C-type lectin receptor signaling pathway|Th17 cell differentiation|Pathways in cancer|Pertussis|Tuberculosis|Rheumatoid arthritis|Inflammatory bowel disease","GO:0001916,GO:0002230,GO:0002827,GO:0005125,GO:0005515,GO:0005576,GO:0005788,GO:0006954,GO:0007165,GO:0010536,GO:0032693,GO:0032725,GO:0032729,GO:0032733,GO:0032735,GO:0032740,GO:0032760,GO:0032816,GO:0032819,GO:0034105,GO:0042098,GO:0042102,GO:0042104,GO:0042509,GO:0042531,GO:0043382,GO:0045087,GO:0045519,GO:0045672,GO:0045944,GO:0048771,GO:0050729,GO:0050829,GO:0051135,GO:0051142,GO:0051607,GO:0070743,GO:0090023,GO:1901224,GO:2000318,GO:2000330","positive regulation of T cell mediated cytotoxicity|positive regulation of defense response to virus by host|positive regulation of T-helper 1 type immune response|cytokine activity|protein binding|extracellular region|endoplasmic reticulum lumen|inflammatory response|signal transduction|positive regulation of activation of Janus kinase activity|negative regulation of interleukin-10 production|positive regulation of granulocyte macrophage colony-stimulating factor production|positive regulation of type II interferon production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-17 production|positive regulation of tumor necrosis factor production|positive regulation of natural killer cell activation|positive regulation of natural killer cell proliferation|positive regulation of tissue remodeling|T cell proliferation|positive regulation of T cell proliferation|positive regulation of activated T cell proliferation|regulation of tyrosine phosphorylation of STAT protein|positive regulation of tyrosine phosphorylation of STAT protein|positive regulation of memory T cell differentiation|innate immune response|interleukin-23 receptor binding|positive regulation of osteoclast differentiation|positive regulation of transcription by RNA polymerase II|tissue remodeling|positive regulation of inflammatory response|defense response to Gram-negative bacterium|positive regulation of NK T cell activation|positive regulation of NK T cell proliferation|defense response to virus|interleukin-23 complex|positive regulation of neutrophil chemotaxis|positive regulation of non-canonical NF-kappaB signal transduction|positive regulation of T-helper 17 type immune response|positive regulation of T-helper 17 cell lineage commitment","WP3893,WP5413,WP5198,WP5095,WP5222,WP5285,WP5130,WP5098","Development and heterogeneity of the ILC family|IL-24 Signaling pathway|Inflammatory bowel disease signaling|Overview of proinflammatory and profibrotic mediators|2q13 copy number variation syndrome|Immune infiltration in pancreatic cancer|Th17 cell differentiation pathway|T-cell activation SARS-CoV-2","R-HSA-1280215,R-HSA-1280215,R-HSA-168256,R-HSA-168256,R-HSA-447115,R-HSA-447115,R-HSA-449147,R-HSA-449147,R-HSA-6785807,R-HSA-9020933,R-HSA-9020933","Cytokine Signaling in Immune system|Cytokine Signaling in Immune system|Immune System|Immune System|Interleukin-12 family signaling|Interleukin-12 family signaling|Signaling by Interleukins|Signaling by Interleukins|Interleukin-4 and Interleukin-13 signaling|Interleukin-23 signaling|Interleukin-23 signaling"]
["ILRUN",25.2361070952319,25.0346971399484,26.4080244852143,25.0785837959959,24.0955516481929,26.1264261616926,24.9960161010981,25.711120397681,24.116082735569,27.4147261679105,27.1789419690987,25.9348691306637,23.1029811601793,25.1097564651709,26.1319377473127,25.2513921948975,26.9645395292219,29.5473365053048,25.1748395305814,26.3465207610233,26.6102750678704,27.4818784784482,25.5707446499898,26.3182188615266,26.6607748829665,26.5871835053436,25.1444682508953,26.8095354998642,64771,"inflammation and lipid regulator with UBA-like and NBR1-like domains","protein_coding",null,null,"GO:0000407,GO:0005515,GO:0005634,GO:0005737,GO:0005813,GO:0005829,GO:0016236,GO:0016607,GO:0032480,GO:0032720,GO:0043130,GO:0043392,GO:0045087,GO:0050687,GO:1900181","phagophore assembly site|protein binding|nucleus|cytoplasm|centrosome|cytosol|macroautophagy|nuclear speck|negative regulation of type I interferon production|negative regulation of tumor necrosis factor production|ubiquitin binding|negative regulation of DNA binding|innate immune response|negative regulation of defense response to virus|negative regulation of protein localization to nucleus"]
["ING2",3.82243305411786,3.32000653276097,2.4399169445711,3.36574747917439,3.39219396490529,3.07286229306145,2.45127508476161,2.79027240887098,3.24379361899584,2.85018810255695,3.53233700152852,3.50215008573761,2.76015032816503,2.92080319662935,2.7521352448442,2.51808736425092,3.67503783991951,3.23837575456963,3.56783890558909,3.5297978924682,3.59885761703302,3.43501611384316,3.31476018703632,3.25255277074024,3.45111945849458,4.03755712217213,3.59793577861293,3.68269880342443,3622,"inhibitor of growth family member 2","protein_coding",null,null,"GO:0000122,GO:0003677,GO:0003682,GO:0005515,GO:0005634,GO:0005654,GO:0005886,GO:0006355,GO:0006974,GO:0007141,GO:0007165,GO:0007283,GO:0007286,GO:0016580,GO:0016602,GO:0030317,GO:0030336,GO:0030511,GO:0030512,GO:0035033,GO:0035064,GO:0035091,GO:0044877,GO:0045814,GO:0045893,GO:0046872,GO:0048133,GO:0072520,GO:0140566,GO:1902166,GO:1902455,GO:1902459,GO:2000772","negative regulation of transcription by RNA polymerase II|DNA binding|chromatin binding|protein binding|nucleus|nucleoplasm|plasma membrane|regulation of DNA-templated transcription|DNA damage response|male meiosis I|signal transduction|spermatogenesis|spermatid development|Sin3 complex|CCAAT-binding factor complex|flagellated sperm motility|negative regulation of cell migration|positive regulation of transforming growth factor beta receptor signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|histone deacetylase regulator activity|methylated histone binding|phosphatidylinositol binding|protein-containing complex binding|negative regulation of gene expression, epigenetic|positive regulation of DNA-templated transcription|metal ion binding|male germ-line stem cell asymmetric division|seminiferous tubule development|histone reader activity|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|negative regulation of stem cell population maintenance|positive regulation of stem cell population maintenance|regulation of cellular senescence","WP4533","Transcription co-factors SKI and SKIL protein partners","R-HSA-212436,R-HSA-2990846,R-HSA-3108232,R-HSA-3700989,R-HSA-3899300,R-HSA-392499,R-HSA-5633007,R-HSA-597592,R-HSA-6804758,R-HSA-6811555,R-HSA-73857,R-HSA-74160","Generic Transcription Pathway|SUMOylation|SUMO E3 ligases SUMOylate target proteins|Transcriptional Regulation by TP53|SUMOylation of transcription cofactors|Metabolism of proteins|Regulation of TP53 Activity|Post-translational protein modification|Regulation of TP53 Activity through Acetylation|PI5P Regulates TP53 Acetylation|RNA Polymerase II Transcription|Gene expression (Transcription)"]
["INHBC",0,0,0.0237109241366176,0.00807388484883909,0.0329050328799311,0,0.0392721820460391,0,0,0.0162162962801031,0,0.00846976646379586,0.00800597179116507,0,0.00782920967448954,0,0,0.00778939305759687,0,0.00809546166268387,0.00794586821328076,0,0.00831096776692994,0,0,0,0,0,3626,"inhibin subunit beta C","protein_coding","hsa04350,hsa04060,hsa04550","TGF-beta signaling pathway|Cytokine-cytokine receptor interaction|Signaling pathways regulating pluripotency of stem cells","GO:0005125,GO:0005160,GO:0005179,GO:0005576,GO:0005615,GO:0007165,GO:0008083","cytokine activity|transforming growth factor beta receptor binding|hormone activity|extracellular region|extracellular space|signal transduction|growth factor activity",null,null,"R-HSA-209822,R-HSA-209952,R-HSA-2980736,R-HSA-392499","Glycoprotein hormones|Peptide hormone biosynthesis|Peptide hormone metabolism|Metabolism of proteins"]
["INSIG1",55.2265131111383,71.7865329257474,94.0167604079487,67.5595027749715,67.8928623738941,78.0704698289764,105.83067107241,82.3062409881646,69.4115465419637,51.0470772128348,63.6858597282539,62.8515081897813,84.9616414835285,88.5574518495388,107.877914231501,95.871695884163,74.5328179543596,72.6768649627664,103.88050720855,83.1565769371702,71.6066046031493,77.3682619045403,108.202539414383,86.1530661481158,71.7415165153465,72.7609504122932,101.678226367551,71.4878855101655,3638,"insulin induced gene 1","protein_coding",null,null,"GO:0005515,GO:0005783,GO:0005789,GO:0006641,GO:0006695,GO:0008142,GO:0010894,GO:0032869,GO:0032933,GO:0032937,GO:0036315,GO:0036316,GO:0042472,GO:0042474,GO:0042632,GO:0045599,GO:0045717,GO:0060021,GO:0060363,GO:0070862,GO:0140311,GO:1901303","protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|triglyceride metabolic process|cholesterol biosynthetic process|oxysterol binding|negative regulation of steroid biosynthetic process|cellular response to insulin stimulus|SREBP signaling pathway|SREBP-SCAP-Insig complex|cellular response to sterol|SREBP-SCAP complex retention in endoplasmic reticulum|inner ear morphogenesis|middle ear morphogenesis|cholesterol homeostasis|negative regulation of fat cell differentiation|negative regulation of fatty acid biosynthetic process|roof of mouth development|cranial suture morphogenesis|negative regulation of protein exit from endoplasmic reticulum|protein sequestering activity|negative regulation of cargo loading into COPII-coated vesicle","WP5323,WP1982,WP4545","Fatty Acids and Lipoproteins Transport in Hepatocytes|Sterol regulatory element-binding proteins (SREBP) signaling|Oxysterols derived from cholesterol","R-HSA-1430728,R-HSA-1655829,R-HSA-556833,R-HSA-8957322","Metabolism|Regulation of cholesterol biosynthesis by SREBP (SREBF)|Metabolism of lipids|Metabolism of steroids"]
["INVS",4.57543445145839,4.77795928321207,4.28038499647751,4.80208037978223,4.58691284502298,4.72216936538957,3.93156046908794,3.86762510673491,5.45976465524025,5.48762582140392,5.64252349115585,5.15153370976852,5.00285100749155,4.61931685966043,5.63503448582356,5.79109691708773,4.44569060344102,4.45315048455149,4.49799542290105,5.17291898302282,4.64955118640483,4.23628816287565,4.57555373105696,4.63348492043554,5.13531165041022,3.95785254427496,4.25526481823042,3.63187435154994,27130,"inversin","protein_coding","hsa04310","Wnt signaling pathway","GO:0005515,GO:0005516,GO:0005634,GO:0005737,GO:0005819,GO:0005874,GO:0016020,GO:0016055,GO:0090090,GO:0097543,GO:1904108","protein binding|calmodulin binding|nucleus|cytoplasm|spindle|microtubule|membrane|Wnt signaling pathway|negative regulation of canonical Wnt signaling pathway|ciliary inversin compartment|protein localization to ciliary inversin compartment","WP428,WP4656,WP5399,WP4150,WP4803,WP5234","Wnt signaling|Joubert syndrome|NPHP1 deletion syndrome|Wnt signaling in kidney disease|Ciliopathies|Bardet-Biedl syndrome"]
["IPO4",13.5474632314343,14.153950154088,15.193157621445,14.9882878193176,12.1386083071642,13.7855231422159,15.22798730694,14.4105418646118,12.0068748609065,14.7550123512741,14.2987574206998,12.0017317187052,10.6263368865638,10.4546365995073,11.0152235144507,9.04560617294678,11.3802618036642,13.5831382694854,13.439620215549,12.6792379546416,12.4085749148902,11.8298870519192,11.4343663067277,11.2855605781172,12.1018948138912,12.9018158304858,11.3795776119737,13.2433119435798,79711,"importin 4","protein_coding","hsa03013","Nucleocytoplasmic transport","GO:0000785,GO:0005515,GO:0005634,GO:0005737,GO:0006606,GO:0008139,GO:0016020,GO:0031267,GO:0032991,GO:0034504,GO:0061608","chromatin|protein binding|nucleus|cytoplasm|protein import into nucleus|nuclear localization sequence binding|membrane|small GTPase binding|protein-containing complex|protein localization to nucleus|nuclear import signal receptor activity"]
["IQGAP2",0.0247456076210922,0.00784572615057299,0.0193600517863753,0.0237324779247088,0,0.0232373866129547,0.0269353331817601,0.0283097099663807,0.029039181301886,0.0158887945804437,0.0155145422374665,0.00414935621436266,0.0549099913485844,0.0157279382108912,0.103559744981382,0.0508356223550963,0.0237914027771774,0.0496085182704295,0.0152469455424866,0.0277618845941549,0.0272488815992159,0.0313621494538377,0.0773596476445048,0.068498046569839,0.0204444749954175,0.0352691672190965,0.0199548916729986,0.00387728905407941,10788,"IQ motif containing GTPase activating protein 2","protein_coding","hsa04810","Regulation of actin cytoskeleton","GO:0003779,GO:0005095,GO:0005096,GO:0005516,GO:0005547,GO:0005737,GO:0005829,GO:0005886,GO:0005902,GO:0005938,GO:0007165,GO:0009986,GO:0015629,GO:0030027,GO:0030175,GO:0030667,GO:0031267,GO:0032956,GO:0034314,GO:0051015,GO:0070062,GO:0070493,GO:0071933,GO:1903479","actin binding|GTPase inhibitor activity|GTPase activator activity|calmodulin binding|phosphatidylinositol-3,4,5-trisphosphate binding|cytoplasm|cytosol|plasma membrane|microvillus|cell cortex|signal transduction|cell surface|actin cytoskeleton|lamellipodium|filopodium|secretory granule membrane|small GTPase binding|regulation of actin cytoskeleton organization|Arp2/3 complex-mediated actin nucleation|actin filament binding|extracellular exosome|thrombin-activated receptor signaling pathway|Arp2/3 complex binding|mitotic actomyosin contractile ring assembly actin filament organization","WP4352,WP524","Ciliary landscape|G13 signaling pathway","R-HSA-162582,R-HSA-168249,R-HSA-168256,R-HSA-194315,R-HSA-195258,R-HSA-5626467,R-HSA-6798695,R-HSA-9012999,R-HSA-9013148,R-HSA-9013149,R-HSA-9013408,R-HSA-9716542","Signal Transduction|Innate Immune System|Immune System|Signaling by Rho GTPases|RHO GTPase Effectors|RHO GTPases activate IQGAPs|Neutrophil degranulation|RHO GTPase cycle|CDC42 GTPase cycle|RAC1 GTPase cycle|RHOG GTPase cycle|Signaling by Rho GTPases, Miro GTPases and RHOBTB3"]
["IRF7",2.25399563464356,3.09123898828293,3.60480587782154,4.27315360098888,2.90680053098073,3.8271384555669,3.43564580088558,3.03268382417546,2.75492871718366,4.77090216344202,4.30112588409873,2.86100229027959,2.65448756287853,3.56069204930965,3.01024548191333,3.36722265847195,2.35606982653987,3.80732809096427,4.91729930027603,3.13781983117867,3.27773823773219,3.88640609838651,3.66121362055801,2.50936067793107,2.72836836166362,4.25849903931578,3.51266627486603,4.13947446889041,3665,"interferon regulatory factor 7","protein_coding","hsa04620,hsa04621,hsa04622,hsa04623,hsa05203,hsa05161,hsa05160,hsa05164,hsa05162,hsa05168,hsa05167,hsa05169,hsa05417","Toll-like receptor signaling pathway|NOD-like receptor signaling pathway|RIG-I-like receptor signaling pathway|Cytosolic DNA-sensing pathway|Viral carcinogenesis|Hepatitis B|Hepatitis C|Influenza A|Measles|Herpes simplex virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Epstein-Barr virus infection|Lipid and atherosclerosis","GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0002376,GO:0002753,GO:0002819,GO:0003677,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006357,GO:0006974,GO:0009615,GO:0010008,GO:0016064,GO:0019043,GO:0032479,GO:0032481,GO:0032727,GO:0032728,GO:0034124,GO:0034127,GO:0039530,GO:0045087,GO:0045655,GO:0045893,GO:0045944,GO:0050776,GO:0051607,GO:0060337,GO:0060340,GO:1990837,GO:2000110","negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|immune system process|cytosolic pattern recognition receptor signaling pathway|regulation of adaptive immune response|DNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|regulation of transcription by RNA polymerase II|DNA damage response|response to virus|endosome membrane|immunoglobulin mediated immune response|establishment of viral latency|regulation of type I interferon production|positive regulation of type I interferon production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|regulation of MyD88-dependent toll-like receptor signaling pathway|regulation of MyD88-independent toll-like receptor signaling pathway|MDA-5 signaling pathway|innate immune response|regulation of monocyte differentiation|positive regulation of DNA-templated transcription|positive regulation of transcription by RNA polymerase II|regulation of immune response|defense response to virus|type I interferon-mediated signaling pathway|positive regulation of type I interferon-mediated signaling pathway|sequence-specific double-stranded DNA binding|negative regulation of macrophage apoptotic process","WP5187,WP3851,WP4630,WP4666,WP3858,WP4868,WP5039,WP4329,WP5088,WP75,WP5038,WP254,WP2637,WP4655,WP4217,WP3865","mRNA vaccine activation of dendritic cell and induction of IFN-1|TLR4 signaling and tolerance|Measles virus infection|Hepatitis B infection|Toll-like receptor signaling related to MyD88|Type I interferon induction and signaling during SARS-CoV-2 infection|SARS-CoV-2 innate immunity evasion and cell-specific immune response|miRNA role in immune response in sepsis|Prostaglandin signaling|Toll-like receptor signaling pathway|Mitochondrial immune response to SARS-CoV-2|Apoptosis|Interleukin-1 (IL-1) structural pathway|Cytosolic DNA-sensing pathway|Ebola virus infection in host|Novel intracellular components of RIG-I-like receptor pathway","R-HSA-1280215,R-HSA-1643685,R-HSA-166016,R-HSA-166166,R-HSA-168138,R-HSA-168164,R-HSA-168181,R-HSA-168249,R-HSA-168256,R-HSA-168898,R-HSA-168928,R-HSA-1834949,R-HSA-3134963,R-HSA-5663205,R-HSA-877300,R-HSA-9013973,R-HSA-909733,R-HSA-913531,R-HSA-918233,R-HSA-933541,R-HSA-936964,R-HSA-937061,R-HSA-9679506,R-HSA-9694516,R-HSA-9705671,R-HSA-9705683,R-HSA-975110,R-HSA-975155,R-HSA-9824446","Cytokine Signaling in Immune system|Disease|Toll Like Receptor 4 (TLR4) Cascade|MyD88-independent TLR4 cascade |Toll Like Receptor 9 (TLR9) Cascade|Toll Like Receptor 3 (TLR3) Cascade|Toll Like Receptor 7/8 (TLR7/8) Cascade|Innate Immune System|Immune System|Toll-like Receptor Cascades|DDX58/IFIH1-mediated induction of interferon-alpha/beta|Cytosolic sensors of pathogen-associated DNA |DEx/H-box helicases activate type I IFN and inflammatory cytokines production |Infectious disease|Interferon gamma signaling|TICAM1-dependent activation of IRF3/IRF7|Interferon alpha/beta signaling|Interferon Signaling|TRAF3-dependent IRF activation pathway|TRAF6 mediated IRF7 activation|Activation of IRF3, IRF7 mediated by TBK1, IKBKE|TRIF(TICAM1)-mediated TLR4 signaling |SARS-CoV Infections|SARS-CoV-2 Infection|SARS-CoV-2 activates/modulates innate and adaptive immune responses|SARS-CoV-2-host interactions|TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling|MyD88 dependent cascade initiated on endosome|Viral Infection Pathways"]
["ITGA11",1.80300871556967,2.18246334183685,1.80403185292528,1.98975321607344,2.48103465524607,2.37500257033667,1.90110609679163,1.83583937236473,2.04959650011819,2.35739689676975,1.71420765693815,1.77918798125574,2.20555060043216,2.2770175144208,1.83987288176196,2.21535853608218,0.845370115514947,0.626168995812397,0.260229066141857,0.64602288458352,0.864873609769212,0.572840550606895,0.246269341924196,0.564642048405337,0.768889093109684,0.621908745038625,0.191204210334937,0.534052692799752,22801,"integrin subunit alpha 11","protein_coding","hsa04151,hsa04512,hsa04510,hsa04810,hsa05165,hsa05410,hsa05412,hsa05414","PI3K-Akt signaling pathway|ECM-receptor interaction|Focal adhesion|Regulation of actin cytoskeleton|Human papillomavirus infection|Hypertrophic cardiomyopathy|Arrhythmogenic right ventricular cardiomyopathy|Dilated cardiomyopathy","GO:0001649,GO:0005178,GO:0005518,GO:0005886,GO:0005925,GO:0006929,GO:0007155,GO:0007160,GO:0007229,GO:0007517,GO:0008305,GO:0009897,GO:0016020,GO:0033627,GO:0034681,GO:0038064,GO:0038065,GO:0046872,GO:0098609,GO:0098639","osteoblast differentiation|integrin binding|collagen binding|plasma membrane|focal adhesion|substrate-dependent cell migration|cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|muscle organ development|integrin complex|external side of plasma membrane|membrane|cell adhesion mediated by integrin|integrin alpha11-beta1 complex|collagen receptor activity|collagen-activated signaling pathway|metal ion binding|cell-cell adhesion|collagen binding involved in cell-matrix adhesion","WP306,WP185,WP2118,WP3932,WP4541,WP2911,WP4172","Focal adhesion|Integrin-mediated cell adhesion|Arrhythmogenic right ventricular cardiomyopathy|Focal adhesion: PI3K-Akt-mTOR-signaling pathway|Hippo-Merlin signaling dysregulation|miRNA targets in ECM and membrane receptors|PI3K-Akt signaling pathway","R-HSA-1474244,R-HSA-1474244,R-HSA-216083,R-HSA-216083","Extracellular matrix organization|Extracellular matrix organization|Integrin cell surface interactions|Integrin cell surface interactions"]
["ITGB3BP",3.61178047269597,2.85585286535121,2.71545183003514,4.11163025681207,3.07018652917339,2.59198956732272,3.01360522009932,3.22496321290221,3.61819341754872,1.90899193709155,2.83055893969726,2.56282862182048,3.07872784826033,1.97365065150331,2.73766908509366,2.18556542445646,3.84657914218587,3.47090857502376,5.19031437842148,4.07320331610518,4.84325336144569,5.24040848418923,7.86321211515114,4.74784601813196,4.06843270755215,5.0152311826055,6.89065451064691,4.67225157170547,23421,"integrin subunit beta 3 binding protein","protein_coding",null,null,"GO:0000939,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006355,GO:0006915,GO:0007059,GO:0007155,GO:0007165,GO:0016020,GO:0034080,GO:0051301","inner kinetochore|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|regulation of DNA-templated transcription|apoptotic process|chromosome segregation|cell adhesion|signal transduction|membrane|CENP-A containing chromatin assembly|cell division",null,null,"R-HSA-141424,R-HSA-141444,R-HSA-162582,R-HSA-162582,R-HSA-1640170,R-HSA-193704,R-HSA-193704,R-HSA-194315,R-HSA-195258,R-HSA-204998,R-HSA-204998,R-HSA-205043,R-HSA-205043,R-HSA-2467813,R-HSA-2500257,R-HSA-2555396,R-HSA-5663220,R-HSA-606279,R-HSA-68877,R-HSA-68882,R-HSA-68886,R-HSA-69278,R-HSA-69618,R-HSA-69620,R-HSA-73886,R-HSA-73887,R-HSA-73887,R-HSA-774815,R-HSA-9648025,R-HSA-9716542","Amplification of signal from the kinetochores|Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal|Signal Transduction|Signal Transduction|Cell Cycle|p75 NTR receptor-mediated signalling|p75 NTR receptor-mediated signalling|Signaling by Rho GTPases|RHO GTPase Effectors|Cell death signalling via NRAGE, NRIF and NADE|Cell death signalling via NRAGE, NRIF and NADE|NRIF signals cell death from the nucleus|NRIF signals cell death from the nucleus|Separation of Sister Chromatids|Resolution of Sister Chromatid Cohesion|Mitotic Metaphase and Anaphase|RHO GTPases Activate Formins|Deposition of new CENPA-containing nucleosomes at the centromere|Mitotic Prometaphase|Mitotic Anaphase|M Phase|Cell Cycle, Mitotic|Mitotic Spindle Checkpoint|Cell Cycle Checkpoints|Chromosome Maintenance|Death Receptor Signaling|Death Receptor Signaling|Nucleosome assembly|EML4 and NUDC in mitotic spindle formation|Signaling by Rho GTPases, Miro GTPases and RHOBTB3"]
["ITIH2",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.008124153447917,0,0,0,0,0,0,0,0,0,0,0,0,3698,"inter-alpha-trypsin inhibitor heavy chain 2","protein_coding",null,null,"GO:0004866,GO:0004867,GO:0005515,GO:0005540,GO:0005576,GO:0005788,GO:0030212,GO:0062023,GO:0070062,GO:0072562","endopeptidase inhibitor activity|serine-type endopeptidase inhibitor activity|protein binding|hyaluronic acid binding|extracellular region|endoplasmic reticulum lumen|hyaluronan metabolic process|collagen-containing extracellular matrix|extracellular exosome|blood microparticle",null,null,"R-HSA-381426,R-HSA-392499,R-HSA-597592,R-HSA-8957275","Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)|Metabolism of proteins|Post-translational protein modification|Post-translational protein phosphorylation"]
["ITPR3",19.082264195969,21.5331784844836,16.5973343271498,17.2757596173386,19.0948939619597,18.105529459385,14.4826764818114,15.7501451920339,10.4817330731272,14.228920853393,8.65540682695718,9.57831681620279,9.77756151342176,10.1465260931041,8.63085262767883,10.4896056341141,9.9476203134388,9.39524022849478,6.64779890155902,10.0491670034902,9.81036710605589,8.78490567064862,6.16252918913632,7.81414291771713,9.71765446922692,8.2019809378081,5.81418595928166,8.14851374278747,3710,"inositol 1%2C4%2C5-trisphosphate receptor type 3","protein_coding","hsa04371,hsa04020,hsa04070,hsa04022,hsa04114,hsa04210,hsa04218,hsa04540,hsa04611,hsa04621,hsa04625,hsa04911,hsa04922,hsa04929,hsa04912,hsa04915,hsa04921,hsa04935,hsa04918,hsa04928,hsa04924,hsa04925,hsa04927,hsa04270,hsa04970,hsa04971,hsa04972,hsa04724,hsa04725,hsa04728,hsa04726,hsa04720,hsa04730,hsa04723,hsa04742,hsa04750,hsa04380,hsa04713,hsa05205,hsa05170,hsa05163,hsa05167,hsa05131,hsa05010,hsa05012,hsa05014,hsa05017,hsa05020,hsa05022,hsa04934","Apelin signaling pathway|Calcium signaling pathway|Phosphatidylinositol signaling system|cGMP-PKG signaling pathway|Oocyte meiosis|Apoptosis|Cellular senescence|Gap junction|Platelet activation|NOD-like receptor signaling pathway|C-type lectin receptor signaling pathway|Insulin secretion|Glucagon signaling pathway|GnRH secretion|GnRH signaling pathway|Estrogen signaling pathway|Oxytocin signaling pathway|Growth hormone synthesis, secretion and action|Thyroid hormone synthesis|Parathyroid hormone synthesis, secretion and action|Renin secretion|Aldosterone synthesis and secretion|Cortisol synthesis and secretion|Vascular smooth muscle contraction|Salivary secretion|Gastric acid secretion|Pancreatic secretion|Glutamatergic synapse|Cholinergic synapse|Dopaminergic synapse|Serotonergic synapse|Long-term potentiation|Long-term depression|Retrograde endocannabinoid signaling|Taste transduction|Inflammatory mediator regulation of TRP channels|Osteoclast differentiation|Circadian entrainment|Proteoglycans in cancer|Human immunodeficiency virus 1 infection|Human cytomegalovirus infection|Kaposi sarcoma-associated herpesvirus infection|Shigellosis|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Spinocerebellar ataxia|Prion disease|Pathways of neurodegeneration - multiple diseases|Cushing syndrome","GO:0000822,GO:0005220,GO:0005509,GO:0005515,GO:0005640,GO:0005654,GO:0005730,GO:0005737,GO:0005783,GO:0005789,GO:0005886,GO:0005903,GO:0007186,GO:0007204,GO:0007613,GO:0015278,GO:0016020,GO:0016529,GO:0030667,GO:0031095,GO:0035091,GO:0043025,GO:0043209,GO:0043235,GO:0043533,GO:0045177,GO:0050909,GO:0050913,GO:0050916,GO:0050917,GO:0051209,GO:0051592,GO:0055074,GO:0060291,GO:0070679,GO:0098554","inositol hexakisphosphate binding|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|calcium ion binding|protein binding|nuclear outer membrane|nucleoplasm|nucleolus|cytoplasm|endoplasmic reticulum|endoplasmic reticulum membrane|plasma membrane|brush border|G protein-coupled receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|memory|calcium-release channel activity|membrane|sarcoplasmic reticulum|secretory granule membrane|platelet dense tubular network membrane|phosphatidylinositol binding|neuronal cell body|myelin sheath|receptor complex|inositol 1,3,4,5 tetrakisphosphate binding|apical part of cell|sensory perception of taste|sensory perception of bitter taste|sensory perception of sweet taste|sensory perception of umami taste|release of sequestered calcium ion into cytosol|response to calcium ion|calcium ion homeostasis|long-term synaptic potentiation|inositol 1,4,5 trisphosphate binding|cytoplasmic side of endoplasmic reticulum membrane","WP4698,WP5124,WP4962,WP289,WP3958,WP2059,WP5356,WP536,WP4756,WP3301,WP5087","Vitamin D-sensitive calcium signaling in depression|Alzheimer's disease|Airway smooth muscle cell contraction|Myometrial relaxation and contraction pathways|GPR40 pathway|Alzheimer's disease and miRNA effects|Disturbed pathways in Duchenne Muscular Dystrophy|Calcium regulation in cardiac cells|Renin-angiotensin-aldosterone system (RAAS)|MFAP5-mediated ovarian cancer cell motility and invasiveness|Pleural mesothelioma","R-HSA-109582,R-HSA-111885,R-HSA-112040,R-HSA-112043,R-HSA-114508,R-HSA-1280218,R-HSA-1280218,R-HSA-139853,R-HSA-1430728,R-HSA-1430728,R-HSA-1489509,R-HSA-162582,R-HSA-162582,R-HSA-163685,R-HSA-163685,R-HSA-1643685,R-HSA-168249,R-HSA-168256,R-HSA-168256,R-HSA-194138,R-HSA-195721,R-HSA-2029480,R-HSA-2029485,R-HSA-2454202,R-HSA-2871809,R-HSA-372790,R-HSA-372790,R-HSA-381676,R-HSA-3858494,R-HSA-388396,R-HSA-388396,R-HSA-397014,R-HSA-397014,R-HSA-4086398,R-HSA-416476,R-HSA-418346,R-HSA-418360,R-HSA-418594,R-HSA-422356,R-HSA-422356,R-HSA-4420097,R-HSA-5218921,R-HSA-5576891,R-HSA-5576891,R-HSA-5578775,R-HSA-5578775,R-HSA-5607763,R-HSA-5607764,R-HSA-5621481,R-HSA-5663205,R-HSA-76002,R-HSA-9006925,R-HSA-9006934,R-HSA-9658195,R-HSA-9662851,R-HSA-9664323,R-HSA-9664433,R-HSA-9709957,R-HSA-9717189,R-HSA-9717207,R-HSA-9824443,R-HSA-983695,R-HSA-983695,R-HSA-983705,R-HSA-983705","Hemostasis|Opioid Signalling|G-protein mediated events|PLC beta mediated events|Effects of PIP2 hydrolysis|Adaptive Immune System|Adaptive Immune System|Elevation of cytosolic Ca2+ levels|Metabolism|Metabolism|DAG and IP3 signaling|Signal Transduction|Signal Transduction|Integration of energy metabolism|Integration of energy metabolism|Disease|Innate Immune System|Immune System|Immune System|Signaling by VEGF|Signaling by WNT|Fcgamma receptor (FCGR) dependent phagocytosis|Role of phospholipids in phagocytosis|Fc epsilon receptor (FCERI) signaling|FCERI mediated Ca+2 mobilization|Signaling by GPCR|Signaling by GPCR|Glucagon-like Peptide-1 (GLP1) regulates insulin secretion|Beta-catenin independent WNT signaling|GPCR downstream signalling|GPCR downstream signalling|Muscle contraction|Muscle contraction|Ca2+ pathway|G alpha (q) signalling events|Platelet homeostasis|Platelet calcium homeostasis|G alpha (i) signalling events|Regulation of insulin secretion|Regulation of insulin secretion|VEGFA-VEGFR2 Pathway|VEGFR2 mediated cell proliferation|Cardiac conduction|Cardiac conduction|Ion homeostasis|Ion homeostasis|CLEC7A (Dectin-1) induces NFAT activation|CLEC7A (Dectin-1) signaling|C-type lectin receptors (CLRs)|Infectious disease|Platelet activation, signaling and aggregation|Intracellular signaling by second messengers|Signaling by Receptor Tyrosine Kinases|Leishmania infection|Anti-inflammatory response favouring Leishmania parasite infection|FCGR3A-mediated IL10 synthesis|Leishmania parasite growth and survival|Sensory Perception|Sensory perception of taste|Sensory perception of sweet, bitter, and umami (glutamate) taste|Parasitic Infection Pathways|Antigen activates B Cell Receptor (BCR) leading to generation of second messengers|Antigen activates B Cell Receptor (BCR) leading to generation of second messengers|Signaling by the B Cell Receptor (BCR)|Signaling by the B Cell Receptor (BCR)"]
["JDP2-AS1",0.420932938456031,0.219814857832832,0.278955465102693,0.0870723735902665,0.177431271907062,0.186012931907253,0.392726630280605,0.16186883417047,0.398495506582018,0.222579341593528,0.256146707449072,0.240810034995455,0.26686899478278,0.212457188606277,0.245625272531199,0.203467010234482,0.325348282844299,0.374200916090274,0.251728658157367,0.222231081086829,0.436249087893386,0.243205498841809,0.301479974041414,0.47574818469161,0.23730113708092,0.368592434386905,0.167723736158548,0.271576437235519,101928377,null,"non_coding"]
["JMY",1.67069290029418,1.6060115213452,1.55738213508614,1.01989845754591,1.85830630798759,1.26566299085226,1.64165316451388,1.33908750174037,1.80861309287912,1.1126695861905,1.32046826325204,1.34706888814479,2.29870981176411,1.63233875814864,2.39671896248489,2.49968595658909,0.854398948085887,0.978479588532065,1.24293770257759,1.47554111542278,1.20782785144786,1.07559765622484,1.73414826838437,1.17496775918855,1.19528375929692,1.1033401289628,1.30425171974719,0.832664441316643,133746,"junction mediating and regulatory protein%2C p53 cofactor","protein_coding",null,null,"GO:0000421,GO:0003713,GO:0003779,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005856,GO:0006281,GO:0006357,GO:0008017,GO:0009267,GO:0012505,GO:0031252,GO:0031410,GO:0034314,GO:0043065,GO:0045893,GO:0051091,GO:0070060,GO:0070358,GO:0071933,GO:0072332","autophagosome membrane|transcription coactivator activity|actin binding|protein binding|nucleus|nucleoplasm|cytoplasm|cytoskeleton|DNA repair|regulation of transcription by RNA polymerase II|microtubule binding|cellular response to starvation|endomembrane system|cell leading edge|cytoplasmic vesicle|Arp2/3 complex-mediated actin nucleation|positive regulation of apoptotic process|positive regulation of DNA-templated transcription|positive regulation of DNA-binding transcription factor activity|'de novo' actin filament nucleation|actin polymerization-dependent cell motility|Arp2/3 complex binding|intrinsic apoptotic signaling pathway by p53 class mediator",null,null,"R-HSA-212436,R-HSA-3700989,R-HSA-5633007,R-HSA-6804760,R-HSA-73857,R-HSA-74160","Generic Transcription Pathway|Transcriptional Regulation by TP53|Regulation of TP53 Activity|Regulation of TP53 Activity through Methylation|RNA Polymerase II Transcription|Gene expression (Transcription)"]
["KANSL1L",0.880408034670798,0.883129025896007,0.65632442681319,0.513322143209804,0.770638856808406,0.695453041411652,0.866254136272831,0.507712440793335,1.02401029799744,0.658578237929435,0.649229337633717,0.767075701739115,1.28185996220655,0.799788410572412,1.0199127115336,1.11232361481626,0.735138085110503,0.41438005486159,0.417950917124531,0.638640663437052,0.53405069575343,0.477612570214008,0.733283441810624,0.74488078498488,0.825207208772004,0.508570142108434,0.56656043584123,0.513452493262481,151050,"KAT8 regulatory NSL complex subunit 1 like","protein_coding",null,null,"GO:0035035,GO:0044545","histone acetyltransferase binding|NSL complex"]
["KCMF1",8.80365786173208,7.34283329618752,7.73144766463816,7.57594084650901,6.98146139430279,6.79661650489735,7.21803525216744,7.16577836739555,7.63133066236501,6.70831256433306,7.438266260004,7.63967920865784,7.42368841805984,6.43437168281827,6.78362973047704,6.48736698638731,7.75137674185386,7.97037251529004,8.48681695897394,7.80399508921972,6.99767564654696,7.72036091780314,8.62878745660418,7.8960979563896,7.35696096912555,7.72062041401048,7.87891579097402,7.7201090658527,56888,"potassium channel modulatory factor 1","protein_coding",null,null,"GO:0005576,GO:0005829,GO:0005886,GO:0008270,GO:0045202,GO:0061630,GO:0099536,GO:1904813","extracellular region|cytosol|plasma membrane|zinc ion binding|synapse|ubiquitin protein ligase activity|synaptic signaling|ficolin-1-rich granule lumen",null,null,"R-HSA-168249,R-HSA-168256,R-HSA-6798695","Innate Immune System|Immune System|Neutrophil degranulation"]
["KCNE5",0.201302354098896,0.26109809633475,0.446703294008076,0.473876198724735,0.303997379461332,0.274957336777139,0.204887212890293,0.161506195234447,0.202482880310387,0.158629065241008,0.258154399348476,0.257761501044834,0.156630071335909,0.122129095218041,0.136152773266615,0.242919358085578,0.299107303165618,0.287853239441431,0.0338268961526451,0.193576612819451,0.138181507231093,0.243530390667343,0.307127779650417,0.0357576161000334,0.127002799727134,0.12171946432889,0.301049276791612,0.326882052879699,23630,"potassium voltage-gated channel subfamily E regulatory subunit 5","protein_coding",null,null,"GO:0005249,GO:0005251,GO:0005515,GO:0005886,GO:0008016,GO:0008076,GO:0015459,GO:0044325,GO:0060048,GO:0060306,GO:0060307,GO:0060372,GO:0086005,GO:0086008,GO:0086011,GO:0086014,GO:0086091,GO:0097623,GO:0098915,GO:1901379,GO:1901380,GO:1901381,GO:1902260,GO:1902282,GO:1903765,GO:2001257","voltage-gated potassium channel activity|delayed rectifier potassium channel activity|protein binding|plasma membrane|regulation of heart contraction|voltage-gated potassium channel complex|potassium channel regulator activity|transmembrane transporter binding|cardiac muscle contraction|regulation of membrane repolarization|regulation of ventricular cardiac muscle cell membrane repolarization|regulation of atrial cardiac muscle cell membrane repolarization|ventricular cardiac muscle cell action potential|voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization|membrane repolarization during action potential|atrial cardiac muscle cell action potential|regulation of heart rate by cardiac conduction|potassium ion export across plasma membrane|membrane repolarization during ventricular cardiac muscle cell action potential|regulation of potassium ion transmembrane transport|negative regulation of potassium ion transmembrane transport|positive regulation of potassium ion transmembrane transport|negative regulation of delayed rectifier potassium channel activity|voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization|negative regulation of potassium ion export across plasma membrane|regulation of cation channel activity",null,null,"R-HSA-397014,R-HSA-5576890,R-HSA-5576891,R-HSA-5576893","Muscle contraction|Phase 3 - rapid repolarisation|Cardiac conduction|Phase 2 - plateau phase"]
["KCNK15",0.16425985344653,0.223197676257432,0.258857585565189,0.247554622107343,0.154775392415754,0.181792725563111,0.328399199768663,0.21859866454003,0.0708099197223544,0.0339007055640196,0.0441362559582509,0.0236084371857012,0.061368082356565,0.106265412338483,0.130937781298187,0.111245208910323,0.0282010534188668,0.037995964307503,0.0271093678089479,0.0112825541866871,0.00553703373643635,5.57625160038856E-3,0.0115829026288181,0.0286566749267405,0.0116322166328661,5.57415734358639E-3,0.0113536602371899,0.0110302334091242,60598,"potassium two pore domain channel subfamily K member 15","protein_coding",null,null,"GO:0005244,GO:0005886,GO:0015271,GO:0022841,GO:0030322,GO:0034765,GO:0071805","voltage-gated monoatomic ion channel activity|plasma membrane|outward rectifier potassium channel activity|potassium ion leak channel activity|stabilization of membrane potential|regulation of monoatomic ion transmembrane transport|potassium ion transmembrane transport",null,null,"R-HSA-397014,R-HSA-5576886,R-HSA-5576891","Muscle contraction|Phase 4 - resting membrane potential|Cardiac conduction"]
["KCNMA1-AS1",0,0,0,0,0,0,0.0625619536872723,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,101929328,"KCNMA1 antisense RNA 1","non_coding"]
["KCNU1",0,6.79560908032667E-3,0,0.0205559867102964,0.0349065449514774,0,0.00666575811881353,0.00700587877552023,0,0.0137621470153432,0.013437986756438,0,0.0135887207396292,0.00681141029329349,0,0,0.020607024721923,0.00661055832770347,0.013206206740749,0.0137406139644387,0.033716763873476,0.00679111479029564,0.00705319872507545,0.00697998522599379,0.00708322759448976,0.0407313856248812,0.00691360572354725,0.0134333216313082,157855,"potassium calcium-activated channel subfamily U member 1","protein_coding","hsa04022,hsa04911,hsa04270","cGMP-PKG signaling pathway|Insulin secretion|Vascular smooth muscle contraction","GO:0005244,GO:0005267,GO:0005886,GO:0016020,GO:0022414,GO:0034765,GO:0060072,GO:0071805","voltage-gated monoatomic ion channel activity|potassium channel activity|plasma membrane|membrane|reproductive process|regulation of monoatomic ion transmembrane transport|large conductance calcium-activated potassium channel activity|potassium ion transmembrane transport",null,null,"R-HSA-1187000,R-HSA-1300642,R-HSA-1474165","Fertilization|Sperm Motility And Taxes|Reproduction"]
["KCTD5",16.113924883845,16.8755187190781,14.2133514393056,14.1689978502469,14.4255785815829,14.736601955938,13.8458805309202,14.3568877484346,16.5648980119047,18.9330588995028,15.7374697642591,16.2565162057154,14.9345121345893,15.5315909921254,14.9961595620188,14.2493846408703,17.5901811371744,17.3587232334841,16.1825216741844,19.6915220143782,17.540180892258,18.0854975950301,14.4866587495338,16.4786123765153,16.6454917232699,17.7945812705345,15.4859797455603,17.7831018191236,54442,"potassium channel tetramerization domain containing 5","protein_coding",null,null,"GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0031463,GO:0042802,GO:0043161,GO:0044877,GO:0051260,GO:0097602","protein binding|nucleus|cytoplasm|cytosol|Cul3-RING ubiquitin ligase complex|identical protein binding|proteasome-mediated ubiquitin-dependent protein catabolic process|protein-containing complex binding|protein homooligomerization|cullin family protein binding"]
["KDM4C",1.29804510626201,1.45217120264287,1.53558230839925,1.31800739512443,1.61316013136072,1.51343720324905,1.56463013204801,1.38604946452327,1.49405764944868,1.17466935387325,1.13061490125581,1.29717652036099,1.43533484050983,1.24998541843992,1.68113253482296,1.4248545572862,1.16842179811761,1.3038085853652,1.15942321996119,1.48488832390198,1.34438928596404,1.19450589899686,1.33735873694751,1.39794886945885,1.45101493930796,1.16715477809579,1.46263342248452,1.25102515377796,23081,"lysine demethylase 4C","protein_coding",null,null,"GO:0000785,GO:0001825,GO:0005634,GO:0005654,GO:0005721,GO:0006338,GO:0008270,GO:0008284,GO:0010468,GO:0019827,GO:0019899,GO:0030374,GO:0030521,GO:0032452,GO:0032454,GO:0045944,GO:0050681,GO:0051864,GO:0060765,GO:0062072,GO:0140684,GO:2000736","chromatin|blastocyst formation|nucleus|nucleoplasm|pericentric heterochromatin|chromatin remodeling|zinc ion binding|positive regulation of cell population proliferation|regulation of gene expression|stem cell population maintenance|enzyme binding|nuclear receptor coactivator activity|androgen receptor signaling pathway|histone demethylase activity|histone H3K9 demethylase activity|positive regulation of transcription by RNA polymerase II|nuclear androgen receptor binding|histone H3K36 demethylase activity|regulation of androgen receptor signaling pathway|H3K9me3 modified histone binding|histone H3K9me2/H3K9me3 demethylase activity|regulation of stem cell differentiation",null,null,"R-HSA-162582,R-HSA-194315,R-HSA-195258,R-HSA-3214842,R-HSA-3247509,R-HSA-4839726,R-HSA-5625740,R-HSA-5625886,R-HSA-9716542","Signal Transduction|Signaling by Rho GTPases|RHO GTPase Effectors|HDMs demethylate histones|Chromatin modifying enzymes|Chromatin organization|RHO GTPases activate PKNs|Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3|Signaling by Rho GTPases, Miro GTPases and RHOBTB3","other"]
["KIAA0100",28.3357971570266,27.5629013407662,23.4093204642644,22.8511642447133,27.655344522247,25.9578178005375,23.0353223884623,22.7812499557794,24.6602373819408,27.1699148417475,22.835818147798,23.9374241653793,24.3425402218725,23.5289440159837,23.760845051184,24.1313267031552,23.7181061827145,25.8188225786375,20.5670705342941,26.4281422862441,23.2874356494913,23.9691621790233,20.3856567610066,23.1618144038567,23.9693055634917,22.3522690628936,19.2028993907061,21.34564289958,9703,"KIAA0100","protein_coding",null,null,"GO:0005789,GO:0005886,GO:0031966,GO:0035091,GO:0140268","endoplasmic reticulum membrane|plasma membrane|mitochondrial membrane|phosphatidylinositol binding|endoplasmic reticulum-plasma membrane contact site"]
["KIDINS220",11.4451914169078,11.0209473713058,8.80086948947043,7.32854552352726,12.3772993140002,10.4182042991132,9.36516545671421,8.43806142088382,12.7706730126626,10.5143612354502,8.30517673760968,10.9535301271846,13.0747963013147,10.2265924632928,12.4225436497757,12.8975088500615,9.92704052188867,8.32561057673804,7.24788585449563,9.81918320434237,9.47418333254106,8.06690737165274,9.80310964196031,10.3351704448039,9.84484620869648,6.78080553151405,8.95676157493366,6.92950461477195,57498,"kinase D interacting substrate 220","protein_coding","hsa04722","Neurotrophin signaling pathway","GO:0001701,GO:0005770,GO:0005829,GO:0010976,GO:0016020,GO:0019887,GO:0030165,GO:0032991,GO:0038180,GO:0048813,GO:1990090","in utero embryonic development|late endosome|cytosol|positive regulation of neuron projection development|membrane|protein kinase regulator activity|PDZ domain binding|protein-containing complex|nerve growth factor signaling pathway|dendrite morphogenesis|cellular response to nerve growth factor stimulus","WP2380,WP4565","Brain-derived neurotrophic factor (BDNF) signaling pathway|Neural crest cell migration in cancer","R-HSA-162582,R-HSA-162582,R-HSA-166520,R-HSA-166520,R-HSA-169893,R-HSA-169893,R-HSA-170984,R-HSA-170984,R-HSA-187037,R-HSA-187037,R-HSA-187687,R-HSA-187687,R-HSA-194315,R-HSA-9006934,R-HSA-9006934,R-HSA-9012999,R-HSA-9696270,R-HSA-9696273,R-HSA-9716542","Signal Transduction|Signal Transduction|Signaling by NTRKs|Signaling by NTRKs|Prolonged ERK activation events|Prolonged ERK activation events|ARMS-mediated activation|ARMS-mediated activation|Signaling by NTRK1 (TRKA)|Signaling by NTRK1 (TRKA)|Signalling to ERKs|Signalling to ERKs|Signaling by Rho GTPases|Signaling by Receptor Tyrosine Kinases|Signaling by Receptor Tyrosine Kinases|RHO GTPase cycle|RND2 GTPase cycle|RND1 GTPase cycle|Signaling by Rho GTPases, Miro GTPases and RHOBTB3"]
["KIF26A",0,0.026037840043596,3.67147246411575E-3,0,3.82133741772593E-3,0,0.00364861531731952,0,0.0511367879807394,0.060263549327016,0.0404552998949984,0.0314756329227614,0.0855371824361153,0.0521967669392643,0.0254582773312068,0.0482027604399985,0.015039470820797,0.0253288054537902,0.0216859210936513,0.0188028929667153,0.0110732641892898,0.0148689256368985,0.0270248123499155,0.00382061283297179,0.0271398700127766,0.014863341357191,0.00378427889089566,0.0220588666102971,26153,"kinesin family member 26A","protein_coding","hsa04814","Motor proteins","GO:0001560,GO:0003777,GO:0005515,GO:0005524,GO:0005829,GO:0005874,GO:0007018,GO:0008017,GO:0009968,GO:0010975,GO:0016887,GO:0021987,GO:0048484,GO:2001222","regulation of cell growth by extracellular stimulus|microtubule motor activity|protein binding|ATP binding|cytosol|microtubule|microtubule-based movement|microtubule binding|negative regulation of signal transduction|regulation of neuron projection development|ATP hydrolysis activity|cerebral cortex development|enteric nervous system development|regulation of neuron migration",null,null,"R-HSA-109582,R-HSA-1280218,R-HSA-168256,R-HSA-199991,R-HSA-2132295,R-HSA-5653656,R-HSA-6811434,R-HSA-6811442,R-HSA-8856688,R-HSA-983189,R-HSA-983231","Hemostasis|Adaptive Immune System|Immune System|Membrane Trafficking|MHC class II antigen presentation|Vesicle-mediated transport|COPI-dependent Golgi-to-ER retrograde traffic|Intra-Golgi and retrograde Golgi-to-ER traffic|Golgi-to-ER retrograde transport|Kinesins|Factors involved in megakaryocyte development and platelet production"]
["KISS1R",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.044016800382373,0,0,0,0,0,0,0,0,0,84634,"KISS1 receptor","protein_coding","hsa04080,hsa04929","Neuroactive ligand-receptor interaction|GnRH secretion","GO:0005515,GO:0005886,GO:0005929,GO:0007186,GO:0007218,GO:0008188,GO:0008528,GO:0009986,GO:0016020,GO:0043231","protein binding|plasma membrane|cilium|G protein-coupled receptor signaling pathway|neuropeptide signaling pathway|neuropeptide receptor activity|G protein-coupled peptide receptor activity|cell surface|membrane|intracellular membrane-bounded organelle","WP4871","Kisspeptin/kisspeptin receptor system in the ovary","R-HSA-162582,R-HSA-372790,R-HSA-373076,R-HSA-375276,R-HSA-388396,R-HSA-416476,R-HSA-500792","Signal Transduction|Signaling by GPCR|Class A/1 (Rhodopsin-like receptors)|Peptide ligand-binding receptors|GPCR downstream signalling|G alpha (q) signalling events|GPCR ligand binding"]
["KLC2-AS2",0.139308605866889,0,0.0653939527006457,0.133605060909471,0.272253011063409,0.130817880191448,0.259947342452542,0.0683027922998393,0.350313933165609,0.335430107809368,0.131011690005273,0.350390080323958,0.264962497936026,0.531254801790105,0,0,0.0669683930024253,0,0,0.33490527446917,0.0657433333822352,0.132417964360648,0.206292393718679,0.340251734595279,0.0690568933178549,0.397104697577976,0,0.130966208048904,105369351,null,"non_coding"]
["KLHDC3",21.0393193874288,19.697823732579,23.7327182050548,22.5085905885308,18.8035657233222,20.2902954731436,20.5043814581674,22.0816134038042,23.8063805885431,28.7862141349726,30.6792661340373,29.0336207713412,24.944317318553,25.6113098522474,26.7641513542587,23.0916383937966,29.3071537266997,28.8154723336906,30.3454107862949,27.1028123628182,28.1228140924521,29.0501397864574,27.2897243639698,27.5225810492993,30.5877713767403,31.1600721134514,28.5644546167072,31.5501830255823,116138,"kelch domain containing 3","protein_coding",null,null,"GO:0000785,GO:0003682,GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0007131,GO:0016567,GO:0031462,GO:0043161,GO:0140627,GO:1990756","chromatin|chromatin binding|protein binding|nucleoplasm|cytoplasm|cytosol|reciprocal meiotic recombination|protein ubiquitination|Cul2-RING ubiquitin ligase complex|proteasome-mediated ubiquitin-dependent protein catabolic process|ubiquitin-dependent protein catabolic process via the C-end degron rule pathway|ubiquitin ligase-substrate adaptor activity",null,null,"R-HSA-2262752,R-HSA-381038,R-HSA-381070,R-HSA-381119,R-HSA-8953897","Cellular responses to stress|XBP1(S) activates chaperone genes|IRE1alpha activates chaperones|Unfolded Protein Response (UPR)|Cellular responses to stimuli"]
["KLHL42",5.78795423418413,5.56426385753227,5.30663749572056,5.25002795790366,5.74660058196956,5.13322931903579,4.88684565634481,4.66132690727025,6.28172593623934,4.3208295801764,5.00238520379361,5.84654905513244,5.96851065162448,4.84219320335984,6.27628964874682,5.56132514158959,4.91666195477995,4.60620911080718,4.63682008856969,5.56209409142904,4.88522666646792,5.07081063450885,5.46155999305912,5.62817836895115,5.47713067838144,4.66766381088133,5.35721675055686,4.21030572199299,57542,"kelch like family member 42","protein_coding",null,null,"GO:0000209,GO:0004842,GO:0005515,GO:0005819,GO:0005829,GO:0007049,GO:0031463,GO:0032886,GO:0043161,GO:0051301","protein polyubiquitination|ubiquitin-protein transferase activity|protein binding|spindle|cytosol|cell cycle|Cul3-RING ubiquitin ligase complex|regulation of microtubule-based process|proteasome-mediated ubiquitin-dependent protein catabolic process|cell division",null,null,"R-HSA-1280218,R-HSA-168256,R-HSA-392499,R-HSA-597592,R-HSA-8951664,R-HSA-983168,R-HSA-983169","Adaptive Immune System|Immune System|Metabolism of proteins|Post-translational protein modification|Neddylation|Antigen processing: Ubiquitination & Proteasome degradation|Class I MHC mediated antigen processing & presentation"]
["KLRK1-AS1",0.16192779469934,0.14496018691207,0.160966174739469,0.155298179456433,0.102383486581001,0.134169221645116,0.142190277779694,0.186806930176945,0.287430725374751,0.128435358594427,0.134367996551344,0.249160776552626,0.271750406452055,0.199783718305696,0.124016894448062,0.19868866022517,0.274736057511716,0.185079281971353,0.422561283670781,0.265628402499469,0.152835826968807,0.380268832635685,0.423154539058987,0.167504846868601,0.396625704589545,0.416328493891821,0.285737125881009,0.286552212098522,101928100,"KLRK1 antisense RNA 1","non_coding"]
["KPNA1",8.4060666611964,8.41839227934356,7.32965707387013,6.82434668508821,8.42822925150656,7.14580685398727,6.88079752156152,6.36006785188954,8.59199080938609,6.84736081805508,6.86026690836648,7.85777442844687,7.95299411571419,6.43369216284924,6.80702081476906,7.06578428854931,8.2332930241683,8.14916275027749,8.19703520432703,9.89131912376554,8.14678256675611,8.58008356933906,9.65482422420982,9.1323690256801,8.66757331265184,7.9755422457726,7.96113337866757,7.98683891210928,3836,"karyopherin subunit alpha 1","protein_coding","hsa03013,hsa05207,hsa05164,hsa05132","Nucleocytoplasmic transport|Chemical carcinogenesis - receptor activation|Influenza A|Salmonella infection","GO:0000018,GO:0005515,GO:0005634,GO:0005643,GO:0005654,GO:0005737,GO:0005829,GO:0006606,GO:0006607,GO:0008139,GO:0014069,GO:0014841,GO:0014901,GO:0030425,GO:0042564,GO:0042981,GO:0060828,GO:0061608,GO:0098978,GO:0099527","regulation of DNA recombination|protein binding|nucleus|nuclear pore|nucleoplasm|cytoplasm|cytosol|protein import into nucleus|NLS-bearing protein import into nucleus|nuclear localization sequence binding|postsynaptic density|skeletal muscle satellite cell proliferation|satellite cell activation involved in skeletal muscle regeneration|dendrite|NLS-dependent protein nuclear import complex|regulation of apoptotic process|regulation of canonical Wnt signaling pathway|nuclear import signal receptor activity|glutamatergic synapse|postsynapse to nucleus signaling pathway","WP4217","Ebola virus infection in host","R-HSA-109581,R-HSA-1169408,R-HSA-1169410,R-HSA-1280215,R-HSA-140342,R-HSA-162587,R-HSA-162592,R-HSA-162594,R-HSA-162906,R-HSA-162909,R-HSA-1643685,R-HSA-168255,R-HSA-168256,R-HSA-168271,R-HSA-168276,R-HSA-176033,R-HSA-180910,R-HSA-5357801,R-HSA-5663205,R-HSA-68616,R-HSA-68867,R-HSA-69002,R-HSA-69306,R-HSA-75153,R-HSA-909733,R-HSA-913531,R-HSA-9635486,R-HSA-9636249,R-HSA-9637687,R-HSA-9637690,R-HSA-9824439,R-HSA-9824446","Apoptosis|ISG15 antiviral mechanism|Antiviral mechanism by IFN-stimulated genes|Cytokine Signaling in Immune system|Apoptosis induced DNA fragmentation|HIV Life Cycle|Integration of provirus|Early Phase of HIV Life Cycle|HIV Infection|Host Interactions of HIV factors|Disease|Influenza Infection|Immune System|Transport of Ribonucleoproteins into the Host Nucleus|NS1 Mediated Effects on Host Pathways|Interactions of Vpr with host cellular proteins|Vpr-mediated nuclear import of PICs|Programmed Cell Death|Infectious disease|Assembly of the ORC complex at the origin of replication|Assembly of the pre-replicative complex|DNA Replication Pre-Initiation|DNA Replication|Apoptotic execution phase|Interferon alpha/beta signaling|Interferon Signaling|Infection with Mycobacterium tuberculosis|Inhibition of nitric oxide production|Suppression of phagosomal maturation|Response of Mtb to phagocytosis|Bacterial Infection Pathways|Viral Infection Pathways"]
["KRT19",24.8229895691447,22.3749046776028,22.7220933090266,27.3776954740767,25.2603296889014,29.374307974744,24.7337558687636,27.8213980195074,25.6317900238143,30.6317670251006,22.0679295247371,26.0666020158354,24.381029391914,27.5853100335264,22.5261457501918,25.963111141706,34.1765725989377,36.4973300606078,30.3263721264661,30.3600546051018,36.4434215882587,34.8213042878062,23.7590956964242,28.3059089791121,31.7623951536289,38.9911103128326,27.736461032897,36.8096545171351,3880,"keratin 19","protein_coding","hsa04915,hsa05150","Estrogen signaling pathway|Staphylococcus aureus infection","GO:0005200,GO:0005515,GO:0005829,GO:0005856,GO:0005882,GO:0005886,GO:0007219,GO:0008307,GO:0016327,GO:0030018,GO:0030855,GO:0042383,GO:0043034,GO:0043627,GO:0045109,GO:0045214,GO:0060706,GO:0070062,GO:0071944,GO:1990357","structural constituent of cytoskeleton|protein binding|cytosol|cytoskeleton|intermediate filament|plasma membrane|Notch signaling pathway|structural constituent of muscle|apicolateral plasma membrane|Z disc|epithelial cell differentiation|sarcolemma|costamere|response to estrogen|intermediate filament organization|sarcomere organization|cell differentiation involved in embryonic placenta development|extracellular exosome|cell periphery|terminal web","WP2840,WP4970","Hair follicle development: cytodifferentiation - part 3 of 3|Galanin receptor pathway","R-HSA-1266738,R-HSA-6805567,R-HSA-6809371","Developmental Biology|Keratinization|Formation of the cornified envelope"]
["KRTAP1-3",0,0.02587268724528,0,0.0260873655761683,0.0265796960851512,0.153258888902393,0,0.0800197193341205,0.0820816299506101,0.183386511010207,0.204647927475441,0.164198943796615,0.155207598437803,0.0259328466565048,0.151780803497773,0,0.418434197246233,0.327185948956132,0.251397669186913,0.261570819817495,0.462127205187336,0.284411339194389,0.456507789530842,0.159447936978857,0.134838636296719,0.568609047288747,0.263219317809725,0.58815853574334,81850,"keratin associated protein 1-3","protein_coding",null,null,"GO:0005515,GO:0005829,GO:0008150,GO:0030280,GO:0045095","protein binding|cytosol|biological_process|structural constituent of skin epidermis|keratin filament",null,null,"R-HSA-1266738,R-HSA-6805567","Developmental Biology|Keratinization"]
["KRTAP5-6",0,0,0,0,0,0,0,0,0.0483320827576082,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,440023,"keratin associated protein 5-6","protein_coding",null,null,"GO:0005515,GO:0005829,GO:0005882","protein binding|cytosol|intermediate filament",null,null,"R-HSA-1266738,R-HSA-6805567","Developmental Biology|Keratinization"]
["L2HGDH",0.969186809661091,0.972075372031289,0.708099040155284,0.723351406994481,0.795962986178389,0.743674393058132,0.51369420618542,0.587979255538054,0.629682923738811,0.435852663868691,0.51070365561093,0.770201317860393,0.72443964443379,0.431440140513648,0.53659440330029,0.443377833890069,1.00432914961765,0.781606965833134,0.700561739269872,0.957375547900564,0.736798082529026,0.802955266822599,0.833943062240482,1.03897685515727,1.08051624501243,0.791903876836214,0.707959803108435,0.740972286347198,79944,"L-2-hydroxyglutarate dehydrogenase","protein_coding","hsa00650","Butanoate metabolism","GO:0005739,GO:0005743,GO:0006103,GO:0016020,GO:0044281,GO:0047545","mitochondrion|mitochondrial inner membrane|2-oxoglutarate metabolic process|membrane|small molecule metabolic process|2-hydroxyglutarate dehydrogenase activity","WP4519","Cerebral organic acidurias, including diseases","R-HSA-1428517,R-HSA-1430728,R-HSA-71406,R-HSA-880009","The citric acid (TCA) cycle and respiratory electron transport|Metabolism|Pyruvate metabolism and Citric Acid (TCA) cycle|Interconversion of 2-oxoglutarate and 2-hydroxyglutarate"]
["LAMB3",1.67138051215871,1.84434809743681,1.84836036167136,1.92240053384293,1.99355344999823,2.39057263938557,2.15871870999741,2.3796861634985502,1.50767943592422,1.68422624917626,1.8123669225928,1.29856171913175,1.58946804738796,1.46303141382212,1.79776413233838,1.42117472645212,1.18375352935377,1.68405577902694,1.55022275874477,1.48712130260758,1.13964298628459,1.57740124292942,1.23898337701428,1.19706746625793,1.1263191490238,1.446820998766,0.909407642189126,1.57688284964796,3914,"laminin subunit beta 3","protein_coding","hsa04151,hsa04512,hsa04510,hsa05200,hsa05222,hsa05165,hsa05146,hsa05145","PI3K-Akt signaling pathway|ECM-receptor interaction|Focal adhesion|Pathways in cancer|Small cell lung cancer|Human papillomavirus infection|Amoebiasis|Toxoplasmosis","GO:0005198,GO:0005201,GO:0005515,GO:0005576,GO:0005610,GO:0007155,GO:0008544,GO:0035987,GO:0044877,GO:0050873,GO:0062023","structural molecule activity|extracellular matrix structural constituent|protein binding|extracellular region|laminin-5 complex|cell adhesion|epidermis development|endodermal cell differentiation|protein-containing complex binding|brown fat cell differentiation|collagen-containing extracellular matrix","WP306,WP244,WP3932,WP4658,WP5087,WP4172","Focal adhesion|Alpha 6 beta 4 signaling pathway|Focal adhesion: PI3K-Akt-mTOR-signaling pathway|Small cell lung cancer|Pleural mesothelioma|PI3K-Akt signaling pathway","R-HSA-1474228,R-HSA-1474228,R-HSA-1474244,R-HSA-1474244,R-HSA-1474290,R-HSA-1500931,R-HSA-162582,R-HSA-2022090,R-HSA-2214320,R-HSA-3000157,R-HSA-3000157,R-HSA-3000171,R-HSA-446107,R-HSA-446728,R-HSA-6806834,R-HSA-8874081,R-HSA-8875878,R-HSA-9006934","Degradation of the extracellular matrix|Degradation of the extracellular matrix|Extracellular matrix organization|Extracellular matrix organization|Collagen formation|Cell-Cell communication|Signal Transduction|Assembly of collagen fibrils and other multimeric structures|Anchoring fibril formation|Laminin interactions|Laminin interactions|Non-integrin membrane-ECM interactions|Type I hemidesmosome assembly|Cell junction organization|Signaling by MET|MET activates PTK2 signaling|MET promotes cell motility|Signaling by Receptor Tyrosine Kinases"]
["LARP6",16.5387289101539,16.1392274843034,19.0898041774116,18.6085021212683,15.5749321448497,17.841624439517,20.6736659893492,18.5600065688451,15.0704328426349,15.923936425304,16.8907838979007,15.8747270131398,16.4017579418557,16.2309728161702,16.563703626051,16.8380793011986,18.7441757719026,16.6086233549129,20.3312199587419,15.8145045423647,17.8108449499571,17.8780251755986,18.0218601930312,17.4913275765874,17.8115528492873,18.1513175703903,19.7213666254063,19.013761495818,55323,"La ribonucleoprotein 6%2C translational regulator","protein_coding",null,null,"GO:0003729,GO:0005515,GO:0005634,GO:0005737,GO:0005844,GO:0006396,GO:0017022,GO:0032967,GO:0035613,GO:0045727,GO:0048027,GO:1902416,GO:1990825,GO:1990904","mRNA binding|protein binding|nucleus|cytoplasm|polysome|RNA processing|myosin binding|positive regulation of collagen biosynthetic process|RNA stem-loop binding|positive regulation of translation|mRNA 5'-UTR binding|positive regulation of mRNA binding|sequence-specific mRNA binding|ribonucleoprotein complex"]
["LCAT",3.45962120666221,6.06717974817224,5.90394614545943,7.06798457751802,5.00046523060782,5.04234720954513,4.05155561305502,4.68234817133023,3.80615151716164,7.41035961034629,5.72764542875326,7.46892994213545,3.46142685722776,4.75852134835373,3.26770068760329,3.43400797872762,4.38298283907785,4.88495956894023,4.16335377948247,5.12888623007919,5.03411118021511,4.82998065592747,3.57550499781527,3.30953946553664,4.60899369666747,5.73558807013109,3.10370061651069,5.48849963062702,3931,"lecithin-cholesterol acyltransferase","protein_coding","hsa00564,hsa04979","Glycerophospholipid metabolism|Cholesterol metabolism","GO:0003847,GO:0004607,GO:0004771,GO:0005515,GO:0005576,GO:0005615,GO:0006629,GO:0006644,GO:0006656,GO:0008203,GO:0030301,GO:0034186,GO:0034364,GO:0034372,GO:0034375,GO:0042158,GO:0042632,GO:0043691,GO:0046470,GO:0047179,GO:0070062,GO:0090107","1-alkyl-2-acetylglycerophosphocholine esterase activity|phosphatidylcholine-sterol O-acyltransferase activity|sterol esterase activity|protein binding|extracellular region|extracellular space|lipid metabolic process|phospholipid metabolic process|phosphatidylcholine biosynthetic process|cholesterol metabolic process|cholesterol transport|apolipoprotein A-I binding|high-density lipoprotein particle|very-low-density lipoprotein particle remodeling|high-density lipoprotein particle remodeling|lipoprotein biosynthetic process|cholesterol homeostasis|reverse cholesterol transport|phosphatidylcholine metabolic process|platelet-activating factor acetyltransferase activity|extracellular exosome|regulation of high-density lipoprotein particle assembly","WP5112,WP5323,WP5109,WP430,WP5111,WP5110,WP3601,WP5304,WP4522,WP5108","Familial hyperlipidemia type 5|Fatty Acids and Lipoproteins Transport in Hepatocytes|Familial hyperlipidemia type 2|Statin inhibition of cholesterol production|Familial hyperlipidemia type 4|Familial hyperlipidemia type 3|Lipid particles composition|Cholesterol metabolism|Metabolic pathway of LDL, HDL and TG, including diseases|Familial  hyperlipidemia type 1","R-HSA-174824,R-HSA-382551,R-HSA-8963899,R-HSA-8964058","Plasma lipoprotein assembly, remodeling, and clearance|Transport of small molecules|Plasma lipoprotein remodeling|HDL remodeling"]
["LCMT1",15.7965497495359,15.749242771816,18.8262809927334,18.7505870302699,15.2159377011209,17.6770389479752,18.7090759551133,18.1367587181132,16.9855938798265,17.4637229017833,21.4293668646333,19.1825749828086,17.4740046336199,19.2333503906748,18.1340878104527,17.3890256431166,18.3646418315148,19.6587482082683,20.1802621172824,17.8190671946287,16.3630008722483,19.0115820128215,18.5325512752471,17.9683053696457,18.5942998729054,22.4568058982687,19.7563161656185,19.9254830169398,51451,"leucine carboxyl methyltransferase 1","protein_coding",null,null,"GO:0000086,GO:0003880,GO:0005515,GO:0005654,GO:0005829,GO:0006479,GO:0006481,GO:0008757,GO:0010906,GO:0018423,GO:0031333,GO:0036211,GO:0042981,GO:0090266","G2/M transition of mitotic cell cycle|protein C-terminal carboxyl O-methyltransferase activity|protein binding|nucleoplasm|cytosol|protein methylation|C-terminal protein methylation|S-adenosylmethionine-dependent methyltransferase activity|regulation of glucose metabolic process|protein C-terminal leucine carboxyl O-methyltransferase activity|negative regulation of protein-containing complex assembly|protein modification process|regulation of apoptotic process|regulation of mitotic cell cycle spindle assembly checkpoint",null,null,"R-HSA-1640170,R-HSA-453274,R-HSA-69273,R-HSA-69275,R-HSA-69278","Cell Cycle|Mitotic G2-G2/M phases|Cyclin A/B1/B2 associated events during G2/M transition|G2/M Transition|Cell Cycle, Mitotic"]
["LEAP2",0.407004411217375,0.0297791324739518,0.382110308986002,0.300262244901077,0.244743124928082,0.205798860301181,0.671832547958791,0.276305023902834,0.377899629644852,0.0603072946444717,0.0294433937468296,0.377981773060269,0.0595473209647167,0.26863537668916,0.349395531396732,0.0593695394823389,0.301007759488253,0.347618628159236,0.665517662459619,0.511809942098181,0.23640111515842,0.357113255801888,0.896329668875238,0.428219256222351,0.775987738502028,0.386727397118621,0.63622035109619,0.206032205345228,116842,"liver enriched antimicrobial peptide 2","protein_coding",null,null,"GO:0005576,GO:0042742,GO:0061844","extracellular region|defense response to bacterium|antimicrobial humoral immune response mediated by antimicrobial peptide",null,null,"R-HSA-168249,R-HSA-168256,R-HSA-6803157","Innate Immune System|Immune System|Antimicrobial peptides"]
["LFNG",0.317426767567164,0.12712653515995,0.141163394642918,0.120170030768435,0.171413094275823,0.251014661960164,0.116903805619538,0.163825104555549,0.176448796705107,0.289631996405337,0.180684080064601,0.0924456505695128,0.0556076392089166,0.0477832991073994,0.0155371114829349,0.0316809256239812,0.0642498124374058,0.154580951784475,0.046321987635122,0.112458430559278,0.110380347153687,0.11116215229408,0.0659726527169747,0.073448825013657,0.115943677718047,0.166680605165593,0.080833698156008,0.0863841257614172,3955,"LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase","protein_coding","hsa00514,hsa04330,hsa05165","Other types of O-glycan biosynthesis|Notch signaling pathway|Human papillomavirus infection","GO:0000139,GO:0001541,GO:0001756,GO:0002315,GO:0005576,GO:0007386,GO:0008593,GO:0009887,GO:0014807,GO:0030217,GO:0033829,GO:0045747,GO:0046872,GO:0051446,GO:1902367,GO:1903561","Golgi membrane|ovarian follicle development|somitogenesis|marginal zone B cell differentiation|extracellular region|compartment pattern specification|regulation of Notch signaling pathway|animal organ morphogenesis|regulation of somitogenesis|T cell differentiation|O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity|positive regulation of Notch signaling pathway|metal ion binding|positive regulation of meiotic cell cycle|negative regulation of Notch signaling pathway involved in somitogenesis|extracellular vesicle","WP4785,WP268,WP2854","Somitogenesis in the context of spondylocostal dysostosis|Notch signaling|Gene regulatory network modelling somitogenesis ","R-HSA-1266738,R-HSA-157118,R-HSA-162582,R-HSA-1643685,R-HSA-1912420,R-HSA-1912422,R-HSA-3781865,R-HSA-3906995,R-HSA-5083630,R-HSA-5668914,R-HSA-9758941,R-HSA-9793380,R-HSA-9824272","Developmental Biology|Signaling by NOTCH|Signal Transduction|Disease|Pre-NOTCH Processing in Golgi|Pre-NOTCH Expression and Processing|Diseases of glycosylation|Diseases associated with O-glycosylation of proteins|Defective LFNG causes SCDO3|Diseases of metabolism|Gastrulation|Formation of paraxial mesoderm|Somitogenesis"]
["LGSN",0.0113979768436545,0.0162620505666422,0.0294272787152905,0.0109313231653204,0.00278440579496668,0.010703281106573,0.0186098665619433,0.00838261541861664,0.00573240981543725,0.00823328446441176,0.0241180611146071,0.0114673117196931,0.0243885935600206,0.0244497948551128,0.0238501230866215,0.0135087667796759,0.0191773125416036,0.031638439624218,0.00526712664194992,0.0137006703191933,0.0268950000200053,0.0270854927101326,0.00843923428849144,0.00835163348552048,0.0141252736331976,0.0108301281157629,2.75740321299617E-3,0.0348251053220951,51557,"lengsin%2C lens protein with glutamine synthetase domain","protein_coding",null,null,"GO:0004356,GO:0005737,GO:0005886,GO:0006542,GO:0016020,GO:0019740","glutamine synthetase activity|cytoplasm|plasma membrane|glutamine biosynthetic process|membrane|nitrogen utilization"]
["LHX9",0,0,0,0.00288051022685044,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,56956,"LIM homeobox 9","protein_coding",null,null,"GO:0000785,GO:0000977,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0008584,GO:0008585,GO:0030182,GO:0035262,GO:0045892,GO:0046872,GO:0097380,GO:1990837","chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|male gonad development|female gonad development|neuron differentiation|gonad morphogenesis|negative regulation of DNA-templated transcription|metal ion binding|dorsal spinal cord interneuron anterior axon guidance|sequence-specific double-stranded DNA binding",null,null,"R-HSA-1266738,R-HSA-376176,R-HSA-422475,R-HSA-9010553,R-HSA-9675108","Developmental Biology|Signaling by ROBO receptors|Axon guidance|Regulation of expression of SLITs and ROBOs|Nervous system development"]
["LIN28B",0,0,0.00439441911706023,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,389421,"lin-28 homolog B","protein_coding",null,null,"GO:0003723,GO:0003729,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0008270,GO:0010587,GO:0031054,GO:0031123,GO:0050779,GO:1990837,GO:2000627,GO:2000632,GO:2000635","RNA binding|mRNA binding|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|zinc ion binding|miRNA catabolic process|pre-miRNA processing|RNA 3'-end processing|RNA destabilization|sequence-specific double-stranded DNA binding|positive regulation of miRNA catabolic process|negative regulation of pre-miRNA processing|negative regulation of primary miRNA processing","WP2406,WP4541,WP5087","Cardiac progenitor differentiation|Hippo-Merlin signaling dysregulation|Pleural mesothelioma"]
["LINC00266-1",0,0,0.0350034020679804,0,0,0,0,0,0,0.0359091152758576,0.0350632946279673,0,0.106369799482616,0,0,0.0353507423888615,0,0,0.0344585186949144,0,0.035190414963935,0,0,0,0,0,0,0,140849,"long intergenic non-protein coding RNA 266-1","non_coding"]
["LINC00324",0.463430634416787,0.440799422236204,0.386742459524735,0.296304633650232,0.251580504492692,0.314300265159111,0.54047074603761,0.340828976476132,0.530891229946392,0.446343100477565,0.460042481666081,0.310833148619763,0.269327925910617,0.306822481334722,0.203522062760823,0.537047668039381,0.792107525255047,0.547906056465883,1.07078118981761,0.878910432339005,0.680415244059121,0.758652492089158,1.16918726296718,0.943248003498373,0.765759819885669,0.758367567151063,1.00901995510527,0.798743764561872,284029,"long intergenic non-protein coding RNA 324","non_coding"]
["LINC00460",0,0,0.015807282757745,0,0,0.0316218111393446,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.0162929633947181,0,728192,"long intergenic non-protein coding RNA 460","non_coding"]
["LINC00528",0,0,0,0,0,0,0,0,0,0,0,0,0.0116948547788825,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,200298,"long intergenic non-protein coding RNA 528","non_coding"]
["LINC00605",0,0,0,0,0,0,0,0,0,0,0,0,0.0164538650034085,0,0,0,0.0166346393401403,0,0,0,0,0.0164460052014027,0,0,0,0,0,0,100131366,"long intergenic non-protein coding RNA 605","non_coding"]
["LINC00673",5.13647393964236,3.96713880426427,6.16290653399419,5.47790933041403,4.2662741991858,5.37327961817617,6.61335164396935,5.38938705477143,4.57760449815894,4.75909361877975,4.99479571733328,5.89120029105654,5.73468613696924,5.76866488588233,5.75137800510089,5.99029376886255,6.57796019406673,7.40454835684498,8.31716230883638,6.19393520919738,6.1861369939307,7.24549316654299,7.77865408220553,7.27638189284073,7.27197509443713,7.47703955534873,8.74802982757261,6.95358693040144,100499467,"long intergenic non-protein coding RNA 673","non_coding"]
["LINC00839",9.08281840320203,10.9519668535001,10.6892739562341,11.2446387787687,9.34367375328482,9.97821039622474,10.6227267312853,9.88092007566028,10.2295922079383,12.1142343497931,11.8508766059279,9.86723385521482,10.3051855130151,11.8355667826822,9.97981819980175,10.0416650446292,9.48558207701482,8.85828289296541,9.98268964925194,8.68926693518878,9.26792836769168,8.66688784082942,8.71285675898994,9.15917535761276,8.3327353583578,10.1631077577225,8.59697577630411,9.40707668533754,84856,"long intergenic non-protein coding RNA 839","non_coding"]
["LINC00868",0,0,0,0.0470903083533384,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,283994,"long intergenic non-protein coding RNA 868","non_coding"]
["LINC00954",0.125169821987861,0.00850409056718823,0.06715080516126,0.0428732658142334,0.00873647722069149,0.0923535184038139,0.0250247814749089,0.0701377926899843,0,0.0774993741625226,0.0336328517625477,0.00899508862921206,0.0170050558376852,0.0170477287141601,0.00831480244700349,0.0169542863994341,0.0171918859648017,0.00827251627543124,0.00826318707012376,0.0171951364802081,0.0168773930473797,0.0169969327388294,8.82644072627186E-3,8.73482064931164E-3,0.0354560765691673,0.0254858238744074,0.00865175270147389,0.0168105878988146,400946,"long intergenic non-protein coding RNA 954","non_coding"]
["LINC01018",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.00740151783019106,0,0,0,0,0,0,0,0,0,255167,"long intergenic non-protein coding RNA 1018","non_coding"]
["LINC01085",0.788034517965776,0.284312664980643,0.20409241689637,0.46909922091501,0.45139933462353,0.306208788109419,0.164792726799236,0.319756217177877,0.0136664810620051,0,0.0127776018225909,0.0136694517223157,0.0258418565275308,0,0.0252712997759229,0.0128823521911022,0.130628871431142,0.0502855576016637,0.163243758676159,0.130653569777791,0.0641196321041457,0.0774885366041899,0.0536526588502211,0.185835070366655,0.215524336403305,0.180738680399653,0.0920338915144186,0.166051157432973,152742,"long intergenic non-protein coding RNA 1085","non_coding"]
["LINC01128",1.15030313036778,1.05525144187453,1.01690323263301,1.03040714580761,1.06982341142037,1.02810272190967,0.727285252579842,0.944757890676105,1.21578247035476,1.13038456822992,0.815463697471899,1.0251215297042,0.707999136489136,0.893482484863796,0.871568345093326,0.802771597170215,1.25471627175311,1.25343001935203,0.97409040993488,1.1735359391266,1.15736179009514,1.01570157630082,0.956903567441093,1.02683573408024,1.03334033617475,1.24002210421525,1.04532250905764,1.09514161612994,643837,"long intergenic non-protein coding RNA 1128","non_coding"]
["LINC01189",0,0,0,0,0,0,0,0,0,0,0.0216858528794015,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,643648,"long intergenic non-protein coding RNA 1189","non_coding"]
["LINC01278",3.6487932942425,4.30749195409218,4.08968548673622,4.66587350953417,4.4420583482697,4.21212643355634,4.03203283088768,4.30543645939176,3.80034006753087,4.90168041703123,4.25892801869142,3.76645229510728,3.60122189294762,3.95565950355291,3.89072887942144,3.74586647366185,2.65387705261451,3.54370772392601,3.16501218544639,3.03594578472718,3.52533635782225,3.2551301802249,2.86980775428229,3.54791643919392,3.47211430140416,3.35226255182585,3.73120331985276,3.23566161335288,92249,"long intergenic non-protein coding RNA 1278","non_coding"]
["LINC01305",2.33914003482256,2.21670026455958,2.36624342970982,2.42549014754817,2.4037900940793,2.65858124239221,2.4562027350613,2.70849112981495,3.38603150385433,2.66024108556593,3.93695791795384,3.62992005979413,2.92222328415323,3.69486183651353,3.34736693900332,3.24904224739587,1.95018908152595,2.09244597548876,1.62739540164915,2.10826248285433,1.63752054876846,2.10857481865925,1.77241034526404,2.0154277097612,1.95966348271157,1.79612629063006,2.11319683058622,1.9880821351516,285084,"long intergenic non-protein coding RNA 1305","non_coding"]
["LINC01388",0.00431921410595146,0.00410828922609718,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.00415266272903999,0,0.00399190979272923,0,0,0,0,0,0,0,0,0,101929179,null,"non_coding"]
["LINC01460",0.00942525008225283,0.0358599063777238,0,0.00903936338670726,0.00920995762950519,0,0.00879367321058862,0.00924237084616707,0.0189610478510616,0.00907772389665912,0,0.0189651693825694,0.0089633292571016,0.00898582204076795,0.00876542985234808,0.0178731375854174,0,0.00872085194770112,0.0522661028316569,0.0362540814600192,0.0355841538726224,0.053754285532417,0,0,0.0373776471524613,0,0,0.00886082561449757,100129995,"long intergenic non-protein coding RNA 1460","non_coding"]
["LINC01541",0,0,0,0,0,0,0,0,0.00873809166194592,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,8.61263864454072E-3,0,0,0,100505776,"long intergenic non-protein coding RNA 1541","non_coding"]
["LINC01556",0,0,0.201118884994568,0.0684836537377027,0,0,0.0333111329566668,0.0350108352583282,0,0,0,0,0.0339538035434577,0,0,0,0,0,0.0329980251873154,0.0343333354224023,0,0,0.0704946193104892,0.0348814361028802,0.0353973744556422,0,0,0.100696534797866,729583,"long intergenic non-protein coding RNA 1556","non_coding"]
["LINC01657",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.0143583202725421,0,0,0,0,0,0,0,0,0,0,0,101928751,"long intergenic non-protein coding RNA 1657","non_coding"]
["LINC01725",0,0,0,0,0.00831979747959092,0.00799534422521964,0,0,0,0,0,0,0,0,0,0.0161456644012298,0,0,0,0,0,0.00809313837769597,0,0,0.00844125638471568,0,0,0,101927587,"long intergenic non-protein coding RNA 1725","non_coding"]
["LINC01816",0.285466727150834,0.193947300000548,0.306293006900452,0.11733394532216,0.0796988769149314,0.114886201892792,0.114144805063313,0.559855565326066,0.123060355947132,0.235663755017655,0.613634178905182,0.369261316117502,0.581734985067562,0.194398268052922,0.075852131248761,0.425332003356453,0.627334779835124,0.528264617225344,0.489978240867625,0.235295021881214,0.769823601177761,0.581457097665328,0.161039145474793,0.0796837647735993,0.242587150202812,0.581238721492726,0.552481817744649,0.651759971825827,100133985,"long intergenic non-protein coding RNA 1816","non_coding"]
["LINC01817",0,0,0,0,0.046702976631888,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.047183898563315,0,0,0,0,0,105373683,"long intergenic non-protein coding RNA 1817","non_coding"]
["LINC01923",0,0.00912124975456155,0,0.00919693322162319,0,0,0,0,0.00964578385877559,0,0,0.00964788054680695,0.0182391474032803,0.00914245856869312,0.0267546738289386,0,0.00921976808678,0.0354914785776239,0.00886286339965248,0.00922151129274769,0,0.0364608695891646,0,0.0187374487781391,0.0095072990800462,0,0.00927962803092984,0.0360611330593568,101927619,"long intergenic non-protein coding RNA 1923","non_coding"]
["LINC01997",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.0739760793754904,0,0,0,0,105374201,null,"non_coding"]
["LINC02054",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.0219712176329231,0,0,0,0,0,0,0,105374250,"long intergenic non-protein coding RNA 2054","non_coding"]
["LINC02082",0,0.0344158833021107,0,0,0,0,0,0,0,0,0.0340278684778796,0,0.0344095592957188,0.0344959074316729,0,0.0343068278485193,0,0,0,0,0,0,0,0,0,0,0,0,100507661,"long intergenic non-protein coding RNA 2082","non_coding"]
["LINC02175",0.0138166146772132,0.0262837858124782,0.0648576619557916,0.0265018752290956,0.256519270931477,0.0648725264404033,0.141798543928815,0.13548529277313,0.125078772856567,0.0665358542912482,0.0519749093101391,0.0278013246715267,0.0919763463491409,0.0263449011138865,0.0642468718034739,0.0917017464018597,0.0531353523156096,0.051136107781497,0.0383088298561093,0.093004447825421,0.0130408354786904,0.0787992089301449,0.0545601615370777,0.175479905356109,0.0410943378482981,0.0393848072687536,0.0935905898332171,0.181849030038176,283887,"long intergenic non-protein coding RNA 2175","non_coding"]
["LINC02259",0.0427876432305446,0.122094443143202,0,0.0410358401364806,0,0.0401797774873736,0,0,0.0430385689317749,0,0,0.0860958483081725,0.0406906693258898,0,0,0.0811383706258632,0.0822754542601225,0,0.0395452524070208,0.0411455051490694,0.242311143037381,0.0406712319107705,0.0844816469514592,0.0836047119291256,0,0.0406559571329832,0.0828096329998216,0.0804506706586128,102723640,"long intergenic non-protein coding RNA 2259","non_coding"]
["LINC02331",0,0.00722452326291139,0,0.00728446866328058,0,0.00713250487941543,0,0.0148961288363132,0,0,0,0.00764164334096206,0,0,0.00706371636452959,0.00720163052892276,0,0,0.00701986729118713,0.0146078716505572,0.0430138123734996,0,0,0,0.00753029521386584,0,0.00734996742601966,0.0142811841405821,105370503,null,"non_coding"]
["LINC02332",0,0.0664244379794625,0.0655633670858805,0.334877970025683,0,0.131156786616815,0,0.0684797425389581,0.0702442964430523,0,0.0656755492643014,0.0702595653292081,0,0.332894443479227,0.064945931030351,0.198641865910468,0.0671418862485455,0.323078193917424,0.129085538945197,0.0671545809427818,0,0.132761016081789,0,0.477586502082181,0,0.132711155408183,0.0675778093133259,0,105370400,"long intergenic non-protein coding RNA 2332","non_coding"]
["LINC02399",0,0,0,0,0,0,0,0,0,0.0649057258611127,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,105369891,"long intergenic non-protein coding RNA 2399","non_coding"]
["LINC02510",0,0,0,0,0,0,0,0,0.00858862794647393,0,0,0,0,0,0,0.0323833851721848,0,0,0,0,0,0,0,0,0,0.00811316217731373,0,0,729307,"long intergenic non-protein coding RNA 2510","non_coding"]
["LINC02561",0.036625292439189,0,0.137540541821466,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.0352196579401002,0,0.104441071075212,0.0361572266164533,0,0,0,0,0,110806285,"long intergenic non-protein coding RNA 2561","non_coding"]
["LINC02579",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.014083363393803,0,0,0,0,0,0,0,0,0,0,339807,"long intergenic non-protein coding RNA 2579","non_coding"]
["LINC02636",0.00961348617519369,0.0182880406990531,0.0361019396507131,0.00921989275534336,0.00939389401582912,0.0090275534297594,0.00896929578540779,0,0.0483493195916872,0.0185180387620863,0.108491135589245,0.0677037608842797,0.00914234011245027,0.0549916926603345,0,0.0638053164158446,0,0,0.00888498895022222,0.00924453218399207,0.0181474108551533,0.00913797293287641,0.0379625089724817,0,0.0285931002646325,0.00913454101062035,0.00930279400675599,0.0180755786429836,102723350,null,"non_coding"]
["LINC02710",0,0,0,0,0,0,0,0,0,0,0,0,0,0.0183436481346155,0,0,0,0,0,0,0,0,0,0,0,0,0,0,105376662,null,"non_coding"]
["LINC02770",0,0,0,0,0,0,0,0,0,0,0,0,0,0.0785915933840867,0,0,0,0,0,0,0,0,0,0,0,0,0,0,107985457,null,"non_coding"]
["LINC02772",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.0093194120739349,0,105371455,null,"non_coding"]
["LINC02861",0.92819105544596,0.643754775539841,1.1074282936902,0.593459495804482,0.944780445494435,0.599237857935794,0.595370787385476,0.872257036242281,0.700225784341933,0.316613296883476,0.381898136539761,0.719832935460366,0.422961118028797,0.589944356650705,0.683376554055372,0.458367768062175,0.539158016259841,0.662009005097369,0.965085715126864,0.502069614480395,1.20460274121165,0.771994832395257,0.572705569362475,1.05795345654933,0.824372856314508,0.477722078793591,0.29939781228056,0.727172489453745,102724927,"long intergenic non-protein coding RNA 2861","non_coding"]
["LINC02923",0.00738931338685392,0,0.00693735189011784,0,0,0,0,0,0,0.00711685590582376,0.0138984440877304,0.00743426321739976,0,0.00704480565696172,0,0.0070061915425293,0,0.0205112142848891,0,0,0.00697441612360883,0,0,0,0.0366296843667898,0,0,0.00694680955522561,105374323,null,"non_coding"]
["LINCR-0003",0,0,0.0192892223286203,0,0,0,0,0,0,0,0.0193222271463569,0,0,0,0,0,0,0,0,0,0,0.0195296311766657,0,0,0,0,0,0,100996645,"uncharacterized LincR-0003","non_coding"]
["LIPT2",0.284228334407877,0.216278642429966,0.202801237540214,0.185362230224254,0.166641578365994,0.20284771679623,0.275789768004795,0.245267808368128,0.148665491164587,0.142349124621588,0.138996164575396,0.183012684720872,0.21623890067744,0.227620612302203,0.338343374140403,0.204813643271105,0.415367856387037,0.24194755002943,0.25218229286974,0.196790395778341,0.311192505503511,0.172908484884254,0.291819775846668,0.299897964975628,0.349420307521849,0.280870762479234,0.374057852985276,0.309960723941977,387787,"lipoyl(octanoyl) transferase 2","protein_coding","hsa00785","Lipoic acid metabolism","GO:0005739,GO:0005759,GO:0009249,GO:0016874,GO:0019752,GO:0033819,GO:2000376","mitochondrion|mitochondrial matrix|protein lipoylation|ligase activity|carboxylic acid metabolic process|lipoyl(octanoyl) transferase activity|positive regulation of oxygen metabolic process",null,null,"R-HSA-1430728,R-HSA-389661,R-HSA-71291","Metabolism|Glyoxylate metabolism and glycine degradation|Metabolism of amino acids and derivatives"]
["LMF1",3.2416196240585,3.64797393001901,3.38801691659207,3.4984510363819,3.35075925880873,3.83623149357135,3.2867595848768,3.74553037473152,4.11703633026877,5.52949388674793,5.06133730195248,4.2279523073851,4.44956183237062,4.7883938036892,4.62010034315475,4.78436599207676,2.76365420395056,3.49081728876133,2.84437048753135,3.2599258237782,3.06698079625407,3.08127892873687,1.92782662921687,2.39621618571713,2.75691286762895,3.72583396200443,2.30540002621207,3.43669599202918,64788,"lipase maturation factor 1","protein_coding",null,null,"GO:0005789,GO:0006641,GO:0051604","endoplasmic reticulum membrane|triglyceride metabolic process|protein maturation","WP5112,WP5111,WP5108","Familial hyperlipidemia type 5|Familial hyperlipidemia type 4|Familial  hyperlipidemia type 1","R-HSA-174824,R-HSA-382551,R-HSA-8963889,R-HSA-8963899","Plasma lipoprotein assembly, remodeling, and clearance|Transport of small molecules|Assembly of active LPL and LIPC lipase complexes|Plasma lipoprotein remodeling"]
["LNP1",1.02676570906773,0.687763762341001,1.2355036653748,1.19276921598418,0.67829559194124,0.923445100621827,1.2413043429024,0.652320980966598,1.17825009259038,1.16997445758228,1.61842311153778,0.960264316698984,1.29275828190943,0.978895398926148,1.47940141177505,0.973529860003986,1.71017300177491,1.65920758301111,3.06072616135241,1.32111506607929,1.77443514080485,1.53957195473389,2.78395126823679,2.07688636581446,1.07530918913666,2.0474113176358,2.72885284711053,1.90336618886525,348801,"leukemia NUP98 fusion partner 1","protein_coding"]
["LOC100129617",0.0140177926340317,0,0,0.0134438789838704,0,0,0.0130784739377449,0.0137458037545698,0,0,0,0,0,0,0.0130364687351614,0,0.0134772584981479,0,0.0129555429102564,0,0,0.0133244285511104,0,0.0136949996139753,0,0,0,0,100129617,"uncharacterized LOC100129617","non_coding"]
["LOC100130027",0.460632522816867,0.63091865356296,0.501651627586703,0.53012807831817,0.420103330468657,0.542138624470782,0.320891934702181,0.409536632983042,0.568356221299994,0.780820762238949,0.814412723686231,0.64262929837679,0.718414209629346,0.942723084277059,0.639722599750316,0.826912581019562,0.212577728710364,0.375062204066544,0.351933825249085,0.543356910102544,0.55650406056432,0.507903900895268,0.321353633140718,0.198011159832139,0.365345423294734,0.338475432590387,0.439802357080392,0.35221226628053,100130027,"uncharacterized LOC100130027","non_coding"]
["LOC100134368",0.2059036173284,0.375376295596224,0.64436561922724,0.279754199784664,0.2682671299339,0.290030984536484,0.512283241395971,0.319688371598166,0.379703733541948,0.0495778937195004,0.129093632163057,0.362523256880051,0.130541676258742,0.392607781590268,0.670212243070688,0.390455812814465,0.0494909638929444,0.0952576826368881,0.269592395467341,0.16500107093516,0.129561655093189,0.130479318160587,0.135514799692983,0.150871647561471,0.255172034188509,0.081518946511074,0.0332081914639641,0.112917714068899,100134368,"uncharacterized LOC100134368","non_coding"]
["LOC100422781",0,0,0,0,0,0,0,0,0,0.015231616511848,0,0,0.00751983622039031,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,100422781,"uncharacterized LOC100422781","non_coding"]
["LOC100506124",0.405102796271656,0.224769982993748,0.174315627205165,0.534211093573845,0.494811749913303,0.110953549605083,0.283467937934315,0.314483676756868,0.424456769364718,0.276367524017261,0.333353789816172,0.458512955454607,0.337093021403583,0.225292620233155,0.21976694507703,0.464119609059023,0.292111349815212,0.26550270613477,0.436805417946053,0.227240673396864,0.254904646401252,0.224621330903566,0.233289958081362,0.24735896297127,0.301221239105934,0.272652035625704,0.277674129438976,0.333238062872087,100506124,"uncharacterized LOC100506124","non_coding"]
["LOC100506317",0,0,0.0155738213508614,0.0159092795606047,0.0162095254279291,0,0,0,0.0166857221089342,0.01597679405812,0,0,0.0157754594924988,0,0.0154271565401326,0,0,0.0153486994279539,0,0,0,0.0157679237561756,0,0,0,0,0.0321046577168539,0.0155950530815157,100506317,null,"non_coding"]
["LOC100507053",0.407834966253419,0.286953572071278,0.351419647580319,0.262544328500136,0.534998326300044,0.398716631315118,0.432630496731508,0.284875728962065,0.421465778658314,0.215231422544622,0.199653669763476,0.303521322222179,0.355969565232291,0.335557599027061,0.348110190322681,0.323124101881028,0.263196194094298,0.180923788593758,0.330458979699705,0.322341988525352,0.221469873739865,0.143381897368333,0.413653659943673,0.212867126642343,0.24371000609667,0.180487171355129,0.394654406389823,0.28887209723533,100507053,"uncharacterized LOC100507053","non_coding"]
["LOC100996720",0.417925817600668,0,0,0.233808856591575,0.340316263829261,0.130817880191448,0,0.204908376899518,0.560502293064975,0.134172043123747,0.0655058450026365,0.24527305622677,0.231842185694023,0.298830826006934,0.25911244834848,0.0660428598117491,0.100452589503637,0.0322243366542961,0.064375992290499,0.267924219575336,0,0.0993134732704862,0.206292393718679,0.136100693838111,0.310756019930347,0,0.235911163778561,0.16370776006113,100996720,"uncharacterized LOC100996720","non_coding"]
["LOC101927044",0,0,0,0,0,0,0,0,0,0,0,0.0526946739969061,0,0,0,0,0.0335709431242727,0,0.0161356923681497,0,0,0,0,0,0,0,0.0168944523283314,0,101927044,null,"non_coding"]
["LOC101927157",0.0809010061081726,0.0615602234335475,0.0759527601895254,0,0.0316212230736913,0.0151940335036286,0,0,0.0162750890918476,0,0,0.0488358803428709,0,0.0154258409583411,0,0.0153412885637136,0.0155562833685105,0,0.0149540870446717,0.0777961231810137,0.061086842782533,0,0.0798671032104131,0.0158076136000447,0.0320828543985712,0,0.0313145671007728,0.0152112612589814,101927157,"uncharacterized LOC101927157","non_coding"]
["LOC101927262",0,0,0,0,0,0.0920482175165286,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.0462594000344091,0.0465870474614281,0,0,0.0485909412981997,0,0,0,101927262,null,"non_coding"]
["LOC101927400",0,0,0,0,0,0.00857785829110314,0,0,0,0,0,0.00919017018538609,0,0,0,0,0,0,0,0,0,0,0,0,0.00905625812064041,8.6795164329988E-3,0,0.00858758429598883,101927400,null,"non_coding"]
["LOC101927556",0.352164875737424,0.106002286506005,0.276218346267552,0.277892782138065,0.209085990305684,0.226048624131048,0.245385218712539,0.393415951017596,0.358714052284017,0.266191830884007,0.134153197372689,0.592006841847827,0.122940057645775,0.293246588643153,0.344094218348005,0.29163924021054,0.19286498497391,0.0659940772493473,0.111239415155188,0.184328052668809,0.0631122954000124,0.207627076084916,0.334461820409779,0.217756608712374,0.274012088352672,0.160956443486624,0.340783482255756,0.163442448989756,101927556,null,"non_coding"]
["LOC101927741",2.18113909562498,1.33425320278635,0.914444961189788,2.23156143002847,2.03369972362452,1.89184956013742,1.16118309285095,1.66942107374852,2.66286192087454,2.55373362405983,1.55799927152194,2.4372995476123,1.77735788020606,2.08341750991554,1.02970790834964,1.61813165014364,1.21659936688532,0.901226522155574,1.14642150816771,1.20482120775448,1.10398243905465,1.00497383112438,1.96423742765306,1.63478453854002,1.79927543596483,1.684874270437,1.42589595055745,1.24831464501709,101927741,null,"non_coding"]
["LOC101927814",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.0200487754793772,0,0.0782746718527946,0,101927814,"uncharacterized LOC101927814","non_coding"]
["LOC101928008",0,0,0,0,0.044873047394182,0,0.0428448132577231,0,0.0923826181499768,0,0,0,0,0.0875620137533095,0,0,0,0,0,0,0,0,0,0.0448645387694626,0,0,0,0,101928008,"uncharacterized LOC101928008","non_coding"]
["LOC101928234",0,0,0.0253327924876375,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.0259476158597735,0,0,0,0,0,0,0,0,101928234,null,"non_coding"]
["LOC101928347",0.0944175664982245,0.0898067707883451,0.0443212954380908,0,0.0461304357624953,0.177325813079126,0,0,0.0474856364746378,0,0.044397131376568,0,0,0.0450077951604139,0,0,0.04538838544998,0.0873612489331881,0,0.0453969671522132,0,0,0.186421847913903,0,0.0468038839124516,0.0897136707312765,0,0.266290310936564,101928347,null,"non_coding"]
["LOC101928391",0,0.0261630949592576,0.0516478769288773,0,0,0.154979141737012,0.153979012544592,0.0269726332857528,0,0.0264921330045358,0.0776043735184296,0.0276736655276268,0,0.0524478592583599,0,0.0782405716749395,0,0,0,0.0264506818815446,0,0,0.0271548150915404,0.0268729431200761,0,0,0,0.0258591441402684,101928391,null,"non_coding"]
["LOC101928519",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.0119337101402087,0,0,0,0,0,0,0,101928519,"uncharacterized LOC101928519","non_coding"]
["LOC101928824",0.507543801500393,0.643677817407678,0.529444763496859,0.324509363422378,0.385739229587225,0.370696273471375,0.21045945926597,0.663594492553251,0.340346842180144,0.869030639144605,0.424280535832976,0.624104841815518,0.160889884991488,0.376351793422959,0.314675264155424,0.16040954025406,0.162657540325974,0.57397071605581,0.260601558749196,0.542294314726229,0.425818745086611,0.482439089820228,0.501057466751855,0.220380621403134,0.111820157799204,0.910931591828976,0.327427209978374,0.636199864204093,101928824,null,"non_coding"]
["LOC101928882",0,0,0,0,0,0,0,0,0,0,0,0,0,0.00894204976917061,0,0,0,0,0,0,0,0,0,0,0,0,0,0,101928882,"uncharacterized LOC101928882","non_coding"]
["LOC101929140",0.0982267083012503,0.186859793254042,0.0658705353856061,0.107663005876034,0.164542293516198,0.0922398848096396,0.0130920902562641,0.220161837543261,0.112917432283261,0.243269768974498,0.171556432175046,0.07058873559884,0.160136106248686,0.200672444325322,0.143550454531426,0.133048343295923,0.31029967002321,0.103869387071005,0.259380624845633,0.188913771689116,0.304623326619091,0.146721310328807,0.152383605771372,0.137092578124282,0.40344899203867,0.0933330405811849,0.135788830790962,0.0923444710058518,101929140,"uncharacterized LOC101929140","non_coding"]
["LOC101929356",0.0506220004417711,0.0372067573214881,0.0583270517941994,0.0353086870316452,0.0562110090063697,0.0648226883919215,0.023614934631252,0.0203071810141135,0.0439753879738238,0.0487554748252489,0.0627547672611686,0.0138899832097691,0.0437646123351439,0.0307121053787749,0.0278189229116774,0.0523607410953073,0.0176981771007689,0.017032274226496,0.0255195995046587,0.0221269041774765,0.0412642535518203,0.0174974826146208,0.0499750587600181,0.0337202103171249,0.052469091542657,0.0284227305948897,0.0445327091676377,0.0173056500264365,101929356,null,"non_coding"]
["LOC101929586",0,0.0101745369286002,0,0,0.0313577128814105,0,0,0,0.0645578533976623,0.0515124808421529,0,0.0107619810385215,0,0.0203963897115844,0,0.0101422963282329,0,0,0,0,0,0,0.0316806176067972,0,0,0.0203279785664916,0,0,101929586,"uncharacterized LOC101929586","non_coding"]
["LOC101929594",0.00390783056469166,0.00371699522471332,0.00366881120544358,0.00374783695070785,0,0.0036696520465418,0,0,0,0,0,0,3.71631221735438E-3,0,0,0,0,0,0,0,0,0.0148581479291304,3.85788906780366E-3,0.00763568694046813,0.00387431396259928,0,0.00378153586473525,0.014695251526508,101929594,null,"non_coding"]
["LOC101930129",0,0,0,0,0.0109070305674471,0.0209633621673253,0.0104140394957695,0,0,0.0107504307844493,0,0,0,0,0,0,0,0,0,0,0.0105352670885817,0,0,0,0,0.0212118037215564,0.0108012564782376,0.0104935657380799,101930129,null,"non_coding"]
["LOC102723323",0.0149479936609481,0.0284360440592301,0.0514569420788629,0.0286719918143986,0.00486885005922086,0.00467897593660727,0.00464878103184537,0.00488598532717889,0,0,4.68590795120524E-3,0,0.00473846981059345,0,0,0,0,0.00461028402410817,0,0.00958287180921026,0.00470289649148336,0,0,0,0,0.00473442754043982,0,0.0140528435808482,102723323,null,"non_coding"]
["LOC102723546",0.0111481452585786,0.00530186787842691,0.00523313889477871,0.0481127406066677,0.0108934982714577,0.00523433825828068,0.0104011188512338,0.0163977547270706,0,0.00536854639049732,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,102723546,null,"non_coding"]
["LOC102723604",0.0509569286110455,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,102723604,"uncharacterized LOC102723604","non_coding"]
["LOC102723798",0,0,0,0,0,0,0,0,0,0.0247554615918427,0,0,6.110875250372E-3,0.024504840082571,0,0,0,0,0,0,0,0,0,0,0,0,0,0,102723798,null,"non_coding"]
["LOC102723961",0,0.00445522729106386,0.00879494689666372,0,0.0320388100334828,0.00439848128880023,0,0.00918616181408786,0.0376914661018498,0.00451125809634145,0.0264299864632705,0,0,0.0044655866266892,0.0261363642513107,0.0310877684152959,0.00450334806115353,0.00433390731023895,0.0129870594351467,0,0.0265258071439704,0,0.0184964161874611,0.009152209993979,0.00464379108844654,0.00890121737403282,0,0.00440346850694405,102723961,null,"non_coding"]
["LOC102724142",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.0170025720662146,0,0.0174754374636195,0,0,0,0,102724142,null,"non_coding"]
["LOC102724200",0.192604209509348,0.223024332302588,0.369509352492092,0.200781137666843,0.270032867683348,0.290957009391326,0.187510944136316,0.270983212320984,0.227426547850106,0.0967839341824606,0.212634536947048,0.193775837524917,0.302620262088164,0.103787779893057,0.19469656242401,0.127038641800046,0.193228466668694,0.216951172405065,0.224446027174983,0.306002918070432,0.276636673085546,0.453713556357803,0.214943985253945,0.122718938758968,0.166045465759613,0.310319001788567,0.153965720255959,0.157452384327201,102724200,null,"protein_coding"]
["LOC102724475",0,0,0.00659735654200987,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.00693736151973662,0,0,0,0,0,102724475,null,"non_coding"]
["LOC102724670",0.0300013525155738,0,0,0,0.0293160587872953,0.0140863994530024,0,0.0147096163717517,0.0301772937418121,0,0,0.0150919266650385,0.0142655101142518,0.0143013083119623,0,0,0.0144222415647961,0.0138795974237202,0,0.0144249684162013,0,0.114069565292311,0,0.0293105000085415,0,0,0,0,102724670,null,"non_coding"]
["LOC102724848",0.0720754418054628,0.0685557033691779,0.0676670045324863,0,0,0,0,0.0706769535295129,0,0,0,0,0,0,0.0670297576944265,0.273353868953442,0,0,0.0666136604717196,0,0.0680285294623663,0,0,0,0,0,0,0,102724848,null,"non_coding"]
["LOC102724892",0,0.00998047219154244,0.0295532810764693,0,0.0307596093659612,0.0197067028548426,0.0097897646486117,0.010289287901922,0.0105544174492091,0.010105990791921,0.00986794940288842,0.042226846581665,0.0399145530172216,0.0300110366328489,0,0.0298465396035191,0.0302648128749769,0.00970869465567349,0,0.161442853990899,0.0891335267303718,0.0299216147572426,0.0207175700970881,0,0.0104028873935421,0,0.0406150788554983,0,102724892,null,"non_coding"]
["LOC105274304",0.0467178773574404,0.0444364524437998,0.0584805538882724,0.119480435752664,0.0913014863791502,0.0584939568273723,0.0290582384544003,0.0458114048874139,0.0626558022576966,0.0449953038898528,0.0292903085107109,0.0470020662340976,0.0740471452204233,0.0445397764932345,0.0434473646060927,0.0442956442758178,0.0598885455619609,0.115270417425419,0.359813821727659,0.0898498032717981,0.0440947487329723,0.103616483377526,0.384340248262704,0.045642087101689,0.0926343768249908,0.0739839774517026,0.0904160637606371,0.146400700505274,105274304,"uncharacterized LOC105274304","non_coding"]
["LOC105369293",0.0204834462273883,0.00389663116414476,0,0.0157158536692904,0.0120093368481997,0,3.82217407025584E-3,0.0040172007021334,0,0.00394563683046277,0,0,0.0155836605928939,0,0.0228593884903181,0.0077685674003486,0.0118161556650175,0.0113715668254218,0.00378624757088497,0.0157578530358138,0.00386666717612842,0.00778810823823266,0,0,0.00406155284407444,0,0,0.00385136189323146,105369293,null,"non_coding"]
["LOC105369420",0,0,0,0,0.021932122248447,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,105369420,null,"non_coding"]
["LOC105369469",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.0136000358047816,0,0,0,0,0,0,0,0,105369469,null,"non_coding"]
["LOC105369669",0,0,0.0266394312580525,0.027213241353666,0.0831804594327942,0.106582146598085,0,0.111297602610685,0.0570827335305646,0.0546574533567264,0.133425063242212,0.0285475707548151,0.10793735442236,0.081156161168199,0.0263885572397005,0.0807113265699376,0.0545616170356602,0.0262543542846581,0.0786742389992309,0.0272859665725408,0.241035821231921,0.0539428970606009,0.0840370067043463,0.0277215623764995,0.0843947927810837,0,0.13728965471023,0.106702994768265,105369669,null,"protein_coding"]
["LOC105369819",0.0065427706881658,0,0.00614258730464803,0.00627489788494727,0.00639332010203515,0.0061439951012246,0,0.00641582053884413,0,0,0,0.0263302837058974,0,0,0.00608474014022221,0.00620354047260847,0.0062904776922181,0,0,0,0.00617540534439927,0,0.012918310092092,0,0.00648665478495385,0.00621680897907268,0,0,105369819,null,"non_coding"]
["LOC105369914",0.0151524537578657,0,0,0,0,0,0,0,0.0152413144615054,0,0,0,0.014409849171057,0,0,0,0,0,0,0,0,0,0,0.0148035324663713,0,0,0,0,105369914,null,"protein_coding"]
["LOC105369955",0.0547334319497322,0.052060574741264,0.205542819859085,0.209970187094276,0.347640837223353,0.154192445586063,0.127664494326312,0.295192880020726,0,0,0.0257368142294622,0.0275331900680957,0.0260255042388939,0,0,0,0.0263114396872473,0.0759643753413965,0.101171610218977,0,0.0258301218466243,0.0520261443731684,0.135084866952841,0.26736532241294,0,0.0260033025317558,0.158893610527576,0.180095156144407,105369955,null,"non_coding"]
["LOC105370050",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.041991841503711,0,0,0,0,0,0,0,0,0,0,0,0,0,105370050,null,"non_coding"]
["LOC105370135",0.0135936536738492,0,0,0.0130371050357956,0.0132831461524885,0,0,0.0133298944125253,0,0,0,0,0.0129274441126124,0,0,0,0.0130694745798984,0,0,0,0.038491180058888,0.0129212688370072,0,0,0,0,0.0526173159756808,0,105370135,null,"non_coding"]
["LOC105370290",0,0,0,0,0,0.00590327887524378,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,105370290,null,"non_coding"]
["LOC105370328",0,0.02751055049364,0,0.0277388189763763,0,0.027160150018289,0.107939508078469,0.0283617817811564,0.0581851897575498,0.0278565347043402,0.190402719004444,0.058197837375696,0.0550109907195505,0.0827235548388294,0.134491037434096,0.0274233763381404,0.027807691085771,0,0.0267312328502394,0.0278129487595641,0.0545980043324571,0.0824770690036012,0.0571066926817804,0.141284786790099,0.258074205392799,0.0274820311092054,0.0279882343293388,0.299100401107396,105370328,null,"non_coding"]
["LOC105370475",0,0,0.036033402508519,0.0368095575975075,0.0125014137733198,0,0,0,0.0128686750958795,0.0492876893107642,0.0240633716336216,0.0257429446768622,0.0121666453133889,0,0.0475920823497209,0.0121303211899131,0.0123003170820781,0.0591875571201357,0.035472485547826,0.0246052854712043,0,0.0608041673084609,0.0252602931084097,0.0249980866233266,0.0126839191808305,0.012156266252387,0.0371405330730096,0.0240550178049008,105370475,null,"non_coding"]
["LOC105370549",0,0,0,0.00818378578220411,0,0,0,0,0,0,0,0,0,0,0,0.00809072071767866,0,0.00789542151643722,0,0,0,0,0.00842409584986061,0,0,0,0,0,105370549,null,"non_coding"]
["LOC105370639",0,0,0,0,0,0,0,0,0,0,0,0,0,0.0292371456616568,0,0,0,0,0,0,0,0,0,0,0,0,0,0,105370639,null,"non_coding"]
["LOC105370794",0.0344708634721779,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,105370794,null,"non_coding"]
["LOC105370834",0.0201919215245266,0,0.056870695944157,0.0193652279295751,0.00986534787280331,0,0.0659360815265858,0.0495003382397712,0,0,0.0474733371086523,0.0101573753622001,0.0192023383335659,0.00962526256052297,0,0,0.0194133094321637,0,0,0.00970848997899392,0.00952908989472847,0,0,0.00986347725006539,0.040037479721363,0.0191859572987112,0.0390787032133989,0.0569482275448607,105370834,null,"non_coding"]
["LOC105370943",0,0.128199165300362,0.0843581989838329,0.344701057146437,0.0439007980339747,0.168755065446969,0.125749526911417,0.440553010333963,0.225952486891818,0.129811451722225,0.0422512700267006,0.135600961085371,0.0427252027921842,0.0856648367886545,0.125345646888577,0.0425976445785781,0.129583840459692,0.332555154272336,0.166090060109487,0,0.0848089000630834,0.0854095870126182,0,0,0,0,0.0434750573249063,0.549075827245032,105370943,"uncharacterized LOC105370943","non_coding"]
["LOC105371075",0,0,0,0,0,0.0315233621631947,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.0316845205715131,0,0,0,0,0,0,0,105371075,null,"non_coding"]
["LOC105371081",0,0,0,0,0.0124895584733925,0,0,0,0.0257129430317858,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,105371081,null,"non_coding"]
["LOC105371229",0,0,0,0,0,0,0,0,0.01898095794681,0.0181745119667098,0,0,0.0179454824468397,0.01799051525138,0,0,0.0362852895931936,0,0,0,0,0,0,0,0,0,0.00913021854915779,0,105371229,null,"non_coding"]
["LOC105371345",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.0280385911261953,0,0,105371345,null,"non_coding"]
["LOC105371403",0,0.0239624608038061,0.0236518314907942,0,0,0,0.0470091689388476,0,0,0,0.0236923009495517,0,0,0,0,0,0,0,0,0.024225858171882,0,0.0239466131811079,0,0.098450408439905,0,0,0.0487570736354089,0,105371403,null,"non_coding"]
["LOC105371578",0,0,0.0238975067942869,0,0,0,0,0,0,0,0,0.025609246663904,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,105371578,null,"non_coding"]
["LOC105371632",0,0,0,0,0,0,0,0,0,0,0,0,0.00821901945345,0,0.00803755350359587,0,0,0.00799667732299621,0,0,0.008157316453647,0.00821509333240957,0,0,0.00856845710612692,0,0.0083632684818672,0,105371632,null,"non_coding"]
["LOC105371749",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.0217425233111149,0,0.0224776826469545,0,0,0,0.0441329922271032,0,0,0,0,0,0.0226236204639582,0,105371749,null,"non_coding"]
["LOC105371822",0,0,0,0,0.00181758755315931,0,0,0,0,0,0,0,1.76891537919614E-3,0,0,0,0,0,0,0,0.00526690657305927,0,3.6726081686047E-3,0,0,0,1.79996097122162E-3,0,105371822,null,"non_coding"]
["LOC105371873",0,0,0.0069640780669097,0,0,0,0,0.00727385267474899,0.00746128190066543,0,0,7.46290374713108E-3,0,0,0,0,0,0,0,0,0,0,0,0.00724696870051584,0,0,0,0,105371873,null,"non_coding"]
["LOC105371958",0,0,0.0843581989838329,0,0,0,0,0,0,0,0.169005080106802,0.0904006407235812,0,0,0,0.0851952891571563,0,0,0.249135090164231,0,0.0848089000630834,0,0,0,0,0,0.0869501146498126,0,105371958,null,"non_coding"]
["LOC105372098",0.013929060966409,0.0529953919340086,0.0196156514882959,0.036736645413488,0.0306245070899707,0.0261601961679838,0.022742454163026,0.0307322859553469,0.0280214943051473,0.0368925453802991,0.0163743457021188,0.0385379297749409,0.0198696202108078,0.0497987037267724,0.0226694103661036,0.0363188805346358,0.016739935468246,0.0161100869205691,0.022528686618649,0.0133944804257402,0.0131469681017568,0.0198601287459905,0.0103132872198849,0.0612374004183106,0.0172619930977973,0.0165438916120523,3.36972411767779E-3,0.0360110546224122,105372098,null,"non_coding"]
["LOC105372240",0,0,0,0.152073995799898,0,0.0372253820838902,0,0,0.0398739682750267,0.038179838741831,0,0,0.0376987083460449,0,0,0.0375861569810983,0,0.0366788773094488,0.293100106075566,0,0,0,0,0,0,0,0,0.0372675900845044,105372240,null,"non_coding"]
["LOC105372316",0.0157270800672363,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.0149435548388444,0,0,105372316,null,"non_coding"]
["LOC105372345",0.0739336676775729,0.0562585475810697,0.0277646293967634,0.0425440141842832,0.0288979471424957,0.152740459674985,0.0275917777095814,0.0434994744158603,0.148734494937017,0.0284830393246791,0.0139060680285355,0.104136777575162,0.0984343673763982,0.0422920203564394,0.192522112609993,0.0420602085800552,0.0426496457903542,0.0957715063044302,0.0819972869437952,0.0426577096718273,0.153521322110902,0.0983873465312661,0.0291955225339656,0.0288924676441849,0.0439797329358363,0.042150169490586,0.286177009269816,0.083407442427196,105372345,null,"non_coding"]
["LOC105372470",0.117073681803444,0,0,0,0.14299934213021,0.0549690766928238,0.109228687870937,0,0.0294400634386734,0.0281892403305592,0,0.0294464627764108,0,0.0279038556314835,0,0,0.0281398133462959,0,0,0.112580535261297,0,0.0278207123819603,0.0577887487290112,0.0571888908961446,0.0870521749642015,0.027810263836894,0,0,105372470,null,"non_coding"]
["LOC105372525",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.0429556079783981,0,0,0,0,0,0,0,0,0.0112289990394999,0,0,0,105372525,null,"non_coding"]
["LOC105372613",0,0,0.00652590502711446,0,0,0,0,0.0136323778339545,0.0139836505554503,0,0.00653707117483763,0,0.00661039754391711,0.00662698582686858,0.00646444800869404,0.0263626474957678,0,6.43157209139381E-3,6.42431898309002E-3,0,0.00656077102086772,0,0.00686222764046149,0.00679099645633692,0.00689144345384473,0.0066047583790045,0.00672641423283749,0,105372613,null,"non_coding"]
["LOC105372666",0,0,0,0,0,0,0,0,0.00841014219200316,0,0.00786313958313286,0,0,0,0,0,0.00803869978037797,0,0,0,0,0,0,0,0.00828939755397328,0,0,0,105372666,null,"non_coding"]
["LOC105372768",0.0644542872256078,0.0136237157598685,0.0874062104242689,0.0686837919393804,0.0279920072480179,0.0605258603489395,0.0734986607877572,0.0070226303453873,0.0288143447683509,0.0758727932489096,0.0673505898406492,0.0216154560709944,0.0272424247346552,0.0409661812485595,0.0466216539968142,0.0475319094660011,0.034427162715115,0.0331318232869622,0.0330944593735695,0.0413204063399263,0.101392149384664,0.0476514699060834,0.0636305709637053,0.0629700739423675,0.0568013128884375,0.088462350934945,0.13860273323562,0.0269308833766876,105372768,null,"non_coding"]
["LOC105372912",0,0,0,0,0,0,0,0,0,0,0.00518102636746788,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,105372912,null,"non_coding"]
["LOC105372956",0.0600361141096728,0.399730136794003,0.112728105546324,0.115156255171415,0.29332381759894,0.338261823835795,0.392092066093506,0,0.0603881924877911,0.115644945854989,0.0564604944677513,0.0604013189689852,0,0.114474169428046,0,0,0.173163261193353,0.0555493019385862,0.0554866570521673,0.0577320005432378,0.113330378703452,0.0570665392066491,0.296344307235074,0,0.535690778231823,0,0.464766759820825,0,105372956,null,"non_coding"]
["LOC105373041",0.237499693702582,0.0564754032160188,0,0.22777602895139,0.406130730710779,0,0.166188802085573,0.11644572960369,0.119446248577172,0.0571856615516411,0.167516048564011,0,0,0.0566067203449258,0,0.112592893159237,0,0.164812576456554,0.109751141041511,0.0570961855592814,0,0.0564380530920384,0.410312844775259,0.116015349152751,0,0.225667427257968,0.114912045792703,0.167457893771782,105373041,null,"non_coding"]
["LOC105373138",0.00857931738868336,0,0,0,0,0,0,0.00841285188416226,0.00862963030777154,0.0165259645731668,0,0,0.0163177095323428,0.0327173151325224,0.0159574343588259,0,0.0247454819464722,0,0,0,0,0.00815495738503674,0.00846967498081147,0,0.0340229378918012,0,0.00830204786599102,0.0080655510049214,105373138,null,"non_coding"]
["LOC105373207",0,0.0199531774786556,0,0.0201187387439554,0.0204984270975757,0.0393980697541562,0,0,0,0.0808164679982726,0.0394564389354402,0.0211052079510306,0,0.0199995727911255,0,0.0198899507759898,0.0201686911221312,0,0,0,0,0,0,0.0819781611133839,0,0,0,0,105373207,null,"non_coding"]
["LOC105373233",0,0,0.119940567275591,0,0,0.119968056004954,0,0.0626378687678621,0.0642518920071521,0.06152201503423,0.12014579154512,0.128531716668598,0.1214934676555,0.0608991730725032,0.0594055198524064,0.121130742877473,0,0,0,0,0,0,0,0.124812721600353,0.0633294258625826,0.242779649230137,0.123625755426273,0,105373233,null,"non_coding"]
["LOC105373312",0.0992862439603798,0.0236094227072491,0.0233033698850367,0,0,0.116543553485475,0.115791461244399,0.0243399453223184,0.074901376870216,0.143438068201354,0.116716215543371,0.0499451053721443,0.0236050844155714,0.0709929586646308,0.0692517386124738,0.0235346102644078,0.0477288546812865,0,0.045881232074444,0.0238689394511176,0.0468557458912063,0.0471876171340432,0.122521725551149,0,0.0984346877127435,0.0235849475080842,0.0480387373755871,0.0466702785588638,105373312,null,"non_coding"]
["LOC105373465",0,8.79884456419785E-3,0,0,0,0,0,0,0,0,0,0,8.79722775405304E-3,0,0,0,0,0,0,0,0,0,0,0,0.0366849934303498,0,0,0.0086966236298775,105373465,null,"non_coding"]
["LOC105373622",0.0474581254141604,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,105373622,null,"non_coding"]
["LOC105373746",0,0,0,0,0,0,0,0,0,0,0.0416953322631913,0,0,0.169075335767081,0,0,0,0,0,0,0,0,0,0,0,0,0,0,105373746,null,"non_coding"]
["LOC105373793",0.0452665243245056,0,0.0212489166206128,0,0,0,0,0,0,0,0,0,0,0.0215780445311472,0,0.0214597705685532,0,0,0.0209181435906155,0,0,0.0215137498772338,0,0.0221120774623632,0,0,0,0,105373793,null,"non_coding"]
["LOC105373893",0,0,0,0,0,0,0,0,0,0,0.0119410089571457,0,0,0,0.0472334043857098,0,0,0,0,0,0,0,0,0,0,0,0.0122868744206047,0,105373893,null,"non_coding"]
["LOC105373991",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.0165071140914205,0,0,0,105373991,null,"non_coding"]
["LOC105374027",0.0404596101091829,0.0192419009831688,0,0.00970078021988096,0.0197677139364989,0.00949840893697762,0,0,0,0,0,0.0203528647032452,0,0,0,0,0,0,0,0,0,0.00961458765620467,0,0.0098819828359004,0,0,0.0195760108029597,0,105374027,null,"non_coding"]
["LOC105374127",0.143592429824539,0.148996608581535,0.0490217136952055,0.100155270841579,0.051022719264668,0.0858076603967639,0.0487165237429219,0.128005717288318,0.26260821721083,0.264023291638424,0.135040378777832,0.302065094911724,0.248282050124073,0.174233566349805,0.0242800284529932,0.309425989674902,0.188257395340958,0.0966261949459572,0.108581879490464,0.276163051509008,0.32034354503247,0.347428828525904,0.270627648708911,0.25506522283462,0.194128457971016,0.0992280987652473,0.113687801237043,0.220898451638903,105374127,null,"non_coding"]
["LOC105374235",0,0.00172623934963122,0.00511158547670165,0,0.00709364541045845,0.001704252327277,0,0,0.0018255098920769,0,0.00682710887120995,0,1.72592214874507E-3,0,0.00168781588754564,0.00172076932250366,1.74488440664772E-3,0,0,1.74521431656323E-3,0.00171296505883828,0.00172509769768972,0.00358334596239273,0.00354615017271589,0.00359860199474986,0.00172444980770076,0,0.00341236938766081,105374235,null,"non_coding"]
["LOC105374343",0,0,0,0,0,0,0,0,0,0,0.0107055582837923,0.0114527838754536,0,0.0108528087147788,0,0.0107933221060586,0.043778324479626,0,0,0,0,0.0108204713276121,0.0112380569213301,0.0111214038250315,0,0.0108164075142649,0.0110156395248918,0,105374343,null,"non_coding"]
["LOC105374433",0.361369552066665,0.260114248435518,0.100863064002408,0.355941309009907,0.238591293662906,0.100886180430253,0.0182245691175967,0.143658590326292,0.00982402116920949,0,0,9.82615660038926E-3,0,0.00931139530311462,0,0,0.206582934066177,0.189773321731496,0.0541598022096155,0.131486722976374,0.138275380537636,0.0742692060979288,0.212122396149859,0.0858765791011128,0.203342526084857,0.0742413130254477,0.0661576959292053,0.165273660374759,105374433,null,"non_coding"]
["LOC105374470",0,0,0,0.0920020615159529,0,0,0,0,0,0,0,0,0,0,0,0,0.0922304914303864,0,0,0,0,0,0,0,0,0,0,0,105374470,null,"non_coding"]
["LOC105374545",0,0,0,0,0,0.0347709612871502,0,0,0,0,0,0,0,0,0,0,0,0,0,0.0356066871482332,0,0.140785033537282,0.0365545587770737,0,0.0367101891675959,0,0.107493273605537,0.069620772685338,105374545,null,"non_coding"]
["LOC105374727",0.506220004417711,0.481499212395728,0.118814364765961,0.364120835013842,0.123664219814013,0.297103988462973,0.531336029203171,0.062049719765347,0,0.243777374126244,0,0,0.180529025882468,0,0.353086329263598,0,0.18251245135168,0.409839098575062,0.643306570846606,0.304244932440302,0.298622887546068,0.120295192975518,0.124937646900045,0.309101927906978,0.313673916831101,0.120250014055302,0.428627325738513,0.237952687863502,105374727,"uncharacterized LOC105374727","non_coding"]
["LOC105374759",0,0.4091462722352,0.269228294629254,0.137513719606291,0,0.403934997080511,0.535104369835818,0.421806073724008,0.144224991633075,0.138097289066197,0.269688957617237,0.721281707900913,0.136357030187822,0.273398415282939,0.133346432860188,0.271899859012201,1.10284119540164,1.19401451666929,0.132518664980974,0.413643642190113,0.541333404657979,0.408875682507214,0.141551695689945,0.140082363072737,0.710771747713028,0.13624070741372,0.555000731807314,0.404392998789304,105374759,null,"non_coding"]
["LOC105374838",0.0473082050460567,0.10799508484411,0.0621804906514739,0.108891172843732,0.0369820692458895,0.079964667726714,0.194207763569756,0.102058612432578,0.0475856413250582,0.0455638651183662,0.0711850109259961,0.0285575909621702,0.0809814303537364,0.0902051633436165,0.0967920053193649,0.0538264375159289,0.127355125758911,0.236372126150045,0.0699572032753194,0.0636896025648987,0.0446519305351439,0.22484096265168,0.13077011690275,0.175631520145951,0.196990302560269,0.0539415647464643,0.0457792811424075,0.0978454102604751,105374838,null,"non_coding"]
["LOC105374955",0,0,0,0,0,0,0,0,0,0.0254782044597105,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,105374955,null,"non_coding"]
["LOC105375052",0,0,0,0,0,0,0,0.0160883631284466,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,105375052,null,"non_coding"]
["LOC105375149",0,0,0,0,0,0,0,0,0,0.00619477221294323,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,105375149,null,"non_coding"]
["LOC105375169",0.0461842636811703,0,0.0289062931983436,0.0442933968349219,0.0300862122448713,0,0,0,0.0309700724466227,0.0148271218414877,0,0.0309768043598793,0,0.0146770137273537,0,0,0.0148011239816896,0,0,0.0444117674081903,0,0.0438998448380104,0,0.0150402537165474,0,0.0292555716662244,0.0297944424842305,0,105375169,null,"non_coding"]
["LOC105375249",0.0265840386935336,0.00842861047339662,0.00831934901221232,0.00849854677382734,0,0.0166425113853026,0,0.0347576339513975,0.0267399392771382,0.0341384488421368,0.0166671676633927,0.0891525056445573,0.0421353084735545,0.0591374612939429,0.032964009701138,0.0168038045674864,0.136314362087776,0.0491945494485704,0.0163796903461033,0.0511275507769502,0.0585465779528189,0.0589612533617679,0.0349923981455748,0.0952302192092112,0.0790680997455913,0.084198727790202,0.0428748099851147,0.166613814973458,105375249,null,"non_coding"]
["LOC105375421",0.0171805068420924,0.0163415124665854,0,0,0.117516476572781,0.0161333714576452,0.0160292577324942,0.033694302893611,0,0.0827351508745859,0.0161572734327727,0,0.0163385096719634,0.0655180396089135,0,0,0.0330360332593226,0.031793035781294,0.0158785908326469,0.016521139734808,0,0.0489921149211959,0.016960942504595,0.0167848848041265,0.0340663068374886,0.114272001884293,0,0.0161516642813658,105375421,null,"non_coding"]
["LOC105375451",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.133727230099043,0,0,0,0,0,105375451,null,"non_coding"]
["LOC105375517",0.0493101498205666,0.0469021336464741,0.0771568893144813,0.0630550714292263,0.0321225351468108,0.123479316180709,0.0153353081599289,0.096706758365992,0.0165331087969623,0.110814653909216,0,0,0.0312623435064763,0,0.015286054498607,0.0155845041141139,0.0158029073731332,0.0304166299639331,0.045573492103213,0,0.0155138231822713,0.0624948197653303,0.0162266577986034,0,0,0.0624713487653157,0.063622035109619,0.0463572462026763,105375517,null,"non_coding"]
["LOC105375646",0,0,0,0,0,0,0,0,0,0.0355647812937603,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,105375646,null,"non_coding"]
["LOC105375701",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.07134610861777,0,0,105375701,null,"non_coding"]
["LOC105375859",0,0,0,0,0,0,0,0,0,0,0,0.0865077901661064,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,105375859,null,"non_coding"]
["LOC105375889",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.00690799927740852,0,0,0,0,0,0,0,0,0,0,0,0,0,105375889,null,"non_coding"]
["LOC105375970",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.103785159636156,0,0,0,0,105375970,null,"non_coding"]
["LOC105376078",0.0111308827233377,0.00529365811088521,0,0.0160127465382364,0,0,0,0,0.00279903978806836,0,0,0,0,5.30596697359272E-3,0,0,0,0,0,0,0,0,0.00549431584385458,0,0,0,0.00807836308298042,0.00261607941132064,105376078,null,"non_coding"]
["LOC105376131",0.0701984771751122,0,0.0659048429561195,0.134648850447826,0.480164978496598,0,0.261978181065452,0,0.141220304307386,0.135220262210651,0,0.0706255005652978,0.0667581293627879,0.468479576187954,0.326420955439004,0,0.472441085009297,0,0.0648789297302685,0,0.132513906348567,0.467083678975255,0.0693013510148689,0.274327961017443,0.139192800593801,0.0667011796713006,0,0.0659946907746433,105376131,null,"non_coding"]
["LOC105376219",0,0,0,0,0,0,0,0.0146606659012966,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,105376219,null,"non_coding"]
["LOC105376308",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.0396429094148082,0,105376308,null,"non_coding"]
["LOC105376387",0.0676017936933996,0,0,0,0,0,0,0.00828626351725323,0,0,0,0,0,0,0,0,0,0,0,0.00812591481000431,0,0,0.00834223159552027,0,0,0,0.00817712676957485,7.94418848196333E-3,105376387,null,"non_coding"]
["LOC105376517",0.193755365572277,0,0,0,0,0,0,0,0,0,0,0,0.0230324543354093,0.0461805050073609,0,0,0,0,0,0,0,0,0,0,0,0,0,0,105376517,null,"non_coding"]
["LOC105376571",0,0,0,0,0,0.00915157621729767,0,0,0,0,0,0,0,0,0,0,0,0,0,0.0093715358799399,0,0.00926351269117334,0.00962101185455881,0,0,0,0.0471529905910047,0,105376571,null,"non_coding"]
["LOC105376717",0.333478951363832,0.264328175877036,0.208721317073401,0.7995643078139,0.814653984135614,0.0521922882825677,0.466699275135157,0.109002806680568,0.894492319241837,0.481774460000011,0.365887286829159,0.559179220970605,0,0.3709199118684,0.103377853103981,0.263490585022133,0.160309905723331,0.154278164353145,0.616416717932118,0.267233693236224,0.41967290752866,0.052830672378939,0.823042849166278,0.814499513123956,1.26737197406644,0.792162463725138,0.860537217152785,0.261257332551165,105376717,null,"non_coding"]
["LOC105376875",0,0.011322514047283,0.00558786921950759,0,0,0.00558914988232399,0,0,0,0,0.0223897213654408,0,0.00566021675321496,0.0340465237844067,0,0,0.00572240408300697,0.00550709573204354,0.0220035407519745,0,0,0,0,0,0,0.00565538816378438,0,0,105376875,null,"protein_coding"]
["LOC105376952",0.0498113000959219,0.0473788107054004,0.0311764209364334,0.0477719358533713,0.04867350567364,0.0623671322871459,0.0232367465804898,0.0488448055806057,0.0334022770890276,0.0879535552167834,0.117111620030891,0.0501143065298571,0.0631601396373528,0.0158296587844757,0.0463242304485041,0.0393572324409407,0.0399087897935611,0.0230443208226903,0.0460366658757434,0,0.0156714936981367,0.0394562305263096,0.0983494380894721,0.0486642764231744,0.0329227196969631,0.00788828241262071,0.0482014802493571,0.0234141927232488,105376952,null,"non_coding"]
["LOC105377054",0,0,0,0,0,0,0,0,0.0102627927430046,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,105377054,null,"non_coding"]
["LOC105377202",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.0231809397122906,0,0,0,0,0,105377202,null,"non_coding"]
["LOC105377329",0.0119645873214572,0,0.00374426094025002,0,3.89709702920326E-3,0.00374511907339035,0.0186047532048257,0.011732437026204,0,0.00384114371126573,0,0,0,0,3.70899975998158E-3,0.0151256616346482,3.8344086539338E-3,0.0147605483476403,0,0,0,0,0,0,0,0,0,0.00374936547676624,105377329,null,"non_coding"]
["LOC105377412",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.0269044373827463,0,0,0,0,0,0,0,0,0,105377412,null,"non_coding"]
["LOC105377489",0,0.0289062379482215,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.0292184533167289,0,0,0,0,0,0,0,0,0,0,0,105377489,null,"non_coding"]
["LOC105377611",0,0,0,0,0.0378047776395907,0,0.00902400623691548,0,9.72884765949702E-3,0,0,0.00973096240296891,9.19810609089005E-3,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,105377611,null,"non_coding"]
["LOC105377731",0,0.0699109285891548,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,105377731,null,"non_coding"]
["LOC105377796",0,0,0,0,0,0,0,0,0.0774694240771948,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,105377796,null,"non_coding"]
["LOC105377882",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.00882243242911525,0,0,0,0,0,0,0,0,0,0,0,0,105377882,null,"non_coding"]
["LOC105377996",0.0490113004277147,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.0483849432540175,0,0,0,0,0,105377996,null,"non_coding"]
["LOC105378099",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.0169542863994341,0,0,0,0,0,0,0,0,0,0,0,0,105378099,null,"non_coding"]
["LOC105378302",0.365685090400584,0.397516791629031,0.0490454645254842,0.325662335966837,0.33180835723353,0.122641762679483,0.17059044348448,0.204908376899518,0,0,0,0,0,0,0,0.0247660724294059,0.602715537021827,0.507533302305163,0.458678945069805,0.351650538192628,0.616343750458454,0.422082261399566,0.335225139792854,0.357264321325042,0.388445024912934,0.297828523183482,0.303314353429579,0.515679444192562,105378302,null,"non_coding"]
["LOC105378383",0.120532422003642,0.0327560946152316,0.0242486039876875,0.0165139439706054,0.0673024051622736,0.0404236023906824,0.0401627361582297,0.0590968586203337,0.0346397935829041,0.116088171453922,0.0890636800307326,0.0519709847660319,0.0327500755992469,0.180577426638492,0.0160134968877135,0.0408153732787398,0.0662197843294502,0.0796602892699623,0.0477422721490063,0.0413951904246467,0.00812605238547589,0.0818360782618507,0.0509965866299131,0.0504672326879743,0.247532901215677,0.0245416029962754,0.0999745808812921,0.0566572113708851,105378383,null,"non_coding"]
["LOC105378477",0.124126854498433,0.0196775388028185,0.116534733822639,0.0396816259186228,0.121291537162171,0.135988348978754,0,0,0,0.0398500235524866,0,0,0.0196739230048431,0,0,0.0196151855311948,0.0198900752816105,0.0191417011284921,0,0.0397876719016328,0.039052448225518,0.0786581000883667,0.0408468438829004,0.0202114230680541,0.0410207486017035,0.0196571396728929,0.060057638668328,0.116693605176345,105378477,null,"non_coding"]
["LOC105378598",0,0.00546574995951237,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,105378598,null,"non_coding"]
["LOC105378693",0,0,0.0639077265029037,0,0,0,0.0317549310382367,0,0.0342352252866391,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.0337437092348609,0,0,0,105378693,null,"non_coding"]
["LOC105378808",0.00670886392116553,0.00638124267298968,0,0,0.0131112388354329,0.0251998604450426,0.00625930945303222,0.00657869104530558,0.0539856613778361,0.0129229917095296,0,0.0134993490378667,0.0510405608269,0.0127921607947219,0.0124784118355975,0.0254440883495738,0.0709518290222311,0,0.0372028506965004,0,0.018996518182373,0.0255080897001348,0.0993468844812456,0.0131087527415005,0.139677792930365,0,0.00649204439894071,0,105378808,null,"non_coding"]
["LOC105378913",0.0672224818833993,0.0799246666461114,0,0,0,0,0,0,0.0507125282300839,0.0323719330978118,0,0.0169078505093979,0,0.0160221016437633,0,0.0159342810144307,0.0484727582766931,0,0.0776605642656581,0.0484819231494646,0,0.0319487233214282,0.0331816942515083,0,0,0.0159683622155732,0,0,105378913,null,"non_coding"]
["LOC105378988",0,0,0,0,0,0,0,0,0,0,0,0,0,7.20478021771694E-3,0,0,0,0,0,0,0,0,0,0,0,0,0,0,105378988,null,"non_coding"]
["LOC105379100",0,0,0.00439747344833186,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,105379100,null,"non_coding"]
["LOC105379154",0.148929365940569,0,0.13982021931022,0.107123947317608,0.0727637536474719,0,0.277899506986557,0.182549589917388,0.037450688435108,0,0.105044593989034,0.0749176580582164,0.141630506493428,0.0709929586646308,0.10387760791871,0.105905746189835,0.107389923032894,0,0,0.179017045883382,0.316276284765642,0.353907128505323,0.147026070661379,0.109124934769369,0.147652031569115,0.318396791359136,0.108087159095071,0.140010835676591,105379154,null,"non_coding"]
["LOC105379241",0,0.22360319529133,0.110352295182339,0.150305693523155,0.382855796807919,0.14717011521538,0.0365550950323887,0.0768406413373192,0.0394103174811311,0.113207661385661,0.184235189069915,0,0.186301756361268,0.1120615597526,0.14575075219602,0.148596434576435,0.0376697210638642,0,0,0.0376768433777816,0,0,0,0.114834960425906,0,0.0372285653979352,0,0.0368342460137544,105379241,null,"non_coding"]
["LOC105379381",0.036280235848241,0.0690170472680283,0.136244735909286,0.139179430880122,0.141806077094938,0.0681379806649942,0.169245662061126,0.0711525723285002,0.182464996144133,0.279540138298197,0.0682389287106873,0.365009316515132,0.172510913023624,0.242121342202119,0.236182914729486,0.137596698504155,0.244168743800229,0.134275297821939,0.0670619354412466,0.174439221022299,0.068486325757537,0.206914208105939,0.07163315959545,0.141779188466619,0.143876273022933,0.206836497930924,0.175538589467993,0.27286095566582,105379381,null,"non_coding"]
["LOC105379574",0.0231981198237892,0,0,0.0222483470619473,0.0226682261793329,0,0,0,0,0,0,0.0233392359871552,0,0,0,0,0,0,0,0.0223078039964834,0,0,0,0,0,0,0.0224483944879034,0,105379574,null,"non_coding"]
["LOC107983998",1.72179122038297,1.49683091353445,1.52957173981675,1.6868097748409,1.95382672568788,2.01671575465471,1.39913621975615,1.37975393346351,2.04847034819505,2.69251774863407,1.54960015070454,1.54599996841838,1.0211792975055,1.46500991486091,1.25690003061348,1.33410205548294,1.56639807149079,1.30189861219252,0.855546326113431,1.40646414235521,1.13583348298772,1.07348588072178,1.15146860147782,1.03099079854907,0.807624161687111,1.0554911947986,1.2540881920646,1.35760506736409,107983998,"uncharacterized LOC107983998","non_coding"]
["LOC107984041",0.0238445070634614,0.0567002057940569,0.0447721533748781,0.0228682700450975,0.0931993943224585,0.100760432708274,0.100110193914441,0.128600171083775,0.131913880007607,0.0459306330728794,0.0784853313189485,0.0599738881403678,0.0680277443838405,0.159129727780782,0.0997886618308004,0.21477803989199,0.229250491746471,0.066187447776449,0.121206810783128,0.11464691837202,0.112528394599403,0.113325413992859,0.247167666777489,0.2678974515376,0.271859976745788,0.10195456742327,0.196128078157472,0.168124466546636,107984041,null,"non_coding"]
["LOC107984191",0.0335276308896058,0,0,0,0,0.0314841540013002,0,0.0328770903234301,0,0.0968742177031532,0,0,0,0,0.031180509176263,0,0.0322347861840032,0,0.123947806051856,0,0,0,0.0330991527235194,0,0.099720215350783,0,0,0,107984191,null,"non_coding"]
["LOC107984264",0.0490826934363494,0,0,0,0,0.0184364601726477,0,0.00962606723235172,0,0,0.00923188711435555,0,0.00933544125102351,0,0,0.0930756982780295,0,0,0,0,0,0,0.00969108477411131,0,0.0194646887938892,0.00932747741943899,0,0.0184573643535783,107984264,null,"protein_coding"]
["LOC107984325",0,0,0,0.025904388062107,0.026393265351087,0.0507279755852612,0,0,0,0.0260143189824099,0,0,0.0513729893292797,0.0257509529424813,0,0,0,0.0999664792401811,0,0.0259736154748635,0.0254936573335922,0,0,0,0,0,0,0,107984325,null,"non_coding"]
["LOC107984369",0,0,0,0,0,0,0.206995106027024,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.0365044153493959,0,0,0,0,0,107984369,null,"non_coding"]
["LOC107984433",0.0514977578257669,0.0380978202972846,0.0214879725707067,0.0439016417507667,0.0167738137255687,0.042985794637309,0.053385492214569,0.005610948974748,0.00575552927765192,0.00551099349277119,5.38118488983662E-3,0,0.00544154567508184,0.00545520081439107,0,0,0.0550133052259363,0.0317660410576419,0.0423069565127117,0.005502370673724,0.00540069412416154,0.0489505168614029,0.0225953884862744,0.0167706331507161,0.0283644849437591,0.0271845181424108,0.0332222896135985,0.0322759005614048,107984433,null,"non_coding"]
["LOC107984494",0.017918249956955,0.013634582855662,0.0353268182397066,0.0103107867399559,0.0140071676790134,0.0201913798062047,0.0133740523170877,0.0140564640361807,0.0324419949273017,0.0172575713536593,0.00674043127253931,0.00721089928664566,0.0187441065161138,6.83314305679243E-3,0.0116647105586285,0.00509676683338478,0.012059118362375,0.00331582512236442,0.00993625725196349,0.0103383414958443,0.0101473025866491,6.81278279813492E-3,0.00884462868575833,0.00175056396288717,0,1.70255603521533E-3,0,1.68452281690129E-3,107984494,null,"non_coding"]
["LOC107984525",0,0,0,0.00719927019938256,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.00713530384399483,0,0,0.00744222158563349,0.00713262405841811,0,0,107984525,null,"non_coding"]
["LOC107984611",0,0,0.0550162167285867,0,0,0,0,0,0,0,0.0551103522087399,0,0,0,0,0,0,0.0271104745330708,0,0,0,0.0278509522867233,0.0289257812931626,0,0,0,0,0,107984611,null,"non_coding"]
["LOC107984684",0,0,0,0,0,0,0,0,0.0173587057791409,0,0,0.0173624790122114,0.0164117296256789,0,0.0160493786028908,0.0163627315922835,0,0,0,0,0,0.016403889951207,0,0.0168601051585624,0,0,0,0,107984684,null,"non_coding"]
["LOC107984763",0,0,0,0.00766683845966274,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,107984763,null,"non_coding"]
["LOC107984862",0.177001027037131,0.0396134925609463,0.0390999763540361,0.0998554626727801,0.091565975041894,0.117326812593489,0.00971413881123347,0.0510490162611777,0.209457693526598,0.13036298743831,0.127292354657498,0.020950322299787,0.0792124269611759,0.1290432072135,0.0387317564738748,0.108591909702053,0.0300310174877619,0.0385347803328315,0.0384913233162196,0.0400489273756875,0.019654438021572,0.0395872940962309,0.102787635340709,0.0610324084766502,0.0206450503777596,0.0296793198073921,0.0403013277635284,0.0489416015014736,107984862,"uncharacterized LOC107984862","non_coding"]
["LOC107984919",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.0120389009642708,0,0,0,0,0,0,0,0,0,0.012064650491653,0,0,107984919,null,"non_coding"]
["LOC107984986",0.224168110064391,0.053305266237157,0.0526142613204779,0.429980528664994,0.273809551147451,0.263131598929785,0.104573411152945,0.384682462245872,0.281853414002268,0.107951311203513,0,0.112765872004467,0,0.0534292121342959,0,0.0531363549836734,0.377167103209085,0,0.0517952370403807,0,0,0,0,0.328509159139392,0.72229777605432,0,0.542308407379289,0,107984986,null,"non_coding"]
["LOC107985029",0,0.038382983622863,0.0378854187053142,0.0387014659969802,0.0394318545215342,0,0.150598235822056,0.0395706296707153,0.0405902671063146,0,0,0.0405990901453208,0.0383759306516625,0.153888928362852,0.0375286367929873,0,0,0,0,0,0,0,0,0.0394243776312494,0,0,0.156197810748166,0,107985029,null,"non_coding"]
["LOC107985046",0,0,0,0,0,0.00593650558561101,0,0,0,0,0,0,0,0.00602707575905167,0,0,0,0,0,0,0,6.00911728512792E-3,0,0,0.00626759327251638,0,0,0,107985046,null,"non_coding"]
["LOC107985152",0.165086182543046,0.0448640998426466,0.154988817030664,0.0452363592055691,0.115225191690222,0.221463340481586,0.220034167824002,0.277513707296985,0.355830688018611,0.113570823903959,0.0221791443709714,0.118636011448269,0.201851351774099,0.292294718701445,0.285125705958269,0.290692587675336,0.181394702305781,0.0654636130457354,0.152576170704253,0.181428999082511,0.133557322933989,0.179337715512059,0.442364529312759,0.299528692344505,0.257196145979097,0.268905543241779,0.114107762007628,0.465600338063625,107985152,null,"non_coding"]
["LOC107985236",0.213384884298107,0.0060286463813949,0.0793399473160902,0.0688915820772329,0.0743206550304769,0.0218234860088956,0.0847594585342259,0.174025172198697,0.112630912816989,0.0142437520504048,0.0198689254769342,0.11265539521161,0.0582662064882833,0.0503555353801166,0.0668038560108415,0.0620986118944708,0.0568751082823325,0.00977413456008512,0.085915384961409,0.109708447775793,0.0119645756025981,0.0542219339134891,0.150171937679998,0.121780199953193,0.215743931698645,0.0301119832985886,0.196266423850976,0.0496550694753958,107985236,null,"non_coding"]
["LOC107985314",0.061403679351351,0.0584050866972039,0,0.0588897022459744,0.120002181414054,0,0,0.0602122565376716,0.0617637777380824,0,0,0,0,0,0.0571050783091469,0,0,0,0,0.118094160564527,0.115911936304897,0,0,0,0.121754067034213,0.233378159396623,0.17825763823424,0,107985314,null,"non_coding"]
["LOC107985367",0.293800711010824,0.30274098981012,0.264337680739531,0.410917472756311,0.406710390505488,0.551787679935594,0.456855683601879,0.456158430318545,0.45559901989086,0.589516129528725,0.598655597108564,0.431065725521163,0.360894083530712,0.513522182384304,0.352925981248492,0.30178167821336,0.306010885735878,0.668281815465525,0.565701839609971,0.541506239427808,0.612380341054961,0.779624295619266,0.51966571660196,0.621909709990499,0.81315903126188,0.500167973992968,0.438304392648919,0.35676693868363,107985367,null,"non_coding"]
["LOC107985382",0.255682258328864,0,0.0342919508064361,0,0,0,0,0,0.0367402417710273,0,0,0,0,0.0348231043856319,0,0,0,0,0,0,0,0.0347193443140724,0,0,0,0,0,0,107985382,null,"non_coding"]
["LOC107985502",0,0.0045908385067274,0.0362506137083615,0.0185157237500324,0.0094325797029131,0,0.0180124658064698,0.00946577640824989,0.00970968609741028,0.0371885985238246,0.054468960464144,0.0291353900272956,0.0183599797137407,0.00460151316680328,0.0134659602745114,0.0183051650830058,0.0974489041952928,0.0357266056514595,0.0312255260725088,0.051054315252113,0.0819996527019964,0.0871682445786792,0.0857674016499148,0.0848771202575009,0.11005826453397,0.137582379554768,0.00934110452818041,0.0680625638069732,107985502,null,"non_coding"]
["LOC107985550",0,0,0,0,0,0,0.0195719108033334,0,0,0,0.0394564389354402,0,0,0,0.078036200397558,0,0,0,0,0,0,0,0,0.0204945402783459,0,0,0,0,107985550,null,"non_coding"]
["LOC107985566",0,0,0,0,0.0146092505936688,0,0.0139489214544001,0,0,0.014399495476675,0,0.0150417039473512,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,107985566,null,"non_coding"]
["LOC107985683",0,0,0,0,0,0,0.138566971803214,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,107985683,null,"non_coding"]
["LOC107985814",0,0,0,0,0,0,0.0133633928705013,0,0,0,0,0,0,0,0,0,0,0,0,0,0.0135189532512885,0,0,0,0,0,0,0,107985814,null,"non_coding"]
["LOC107985880",0.0132691189934743,0.0126211336746603,0.0249150476939698,0.00636292869455643,0,0.00623018947010715,0.00618998409605795,0.065058283583652,0.0266938699749133,0.0255597246807236,0,0.0400495085657017,0.0315470362728409,0.00632524022559595,0.00617010321873382,0.0125811404120831,0.0574085436444615,0.0429710696512371,0.0551862124410062,0.0510394649154098,0.0563583633202867,0.0567575399788503,0.0785972496865656,0.0324089149122256,0.059198907070167,0.0378241491416876,0.121982686070374,0.0436607749943985,107985880,null,"non_coding"]
["LOC107985948",0,0.0175856193827658,0,0,0,0,0,0,0,0.0178067835009911,0,0,0,0,0,0,0,0,0.0170874547437744,0,0,0,0,0.0180627464044407,0,0.0175673888846224,0,0,107985948,null,"non_coding"]
["LOC107985976",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.0268340250972192,0,0,0,0,0,0,0,0,107985976,null,"non_coding"]
["LOC107986024",0,0,0,0.0105391680741878,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,107986024,null,"non_coding"]
["LOC107986104",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.125407067893688,0,0,0,0,107986104,null,"non_coding"]
["LOC107986129",0,0,0.0351370492122872,0,0,0,0.0174591498662155,0,0.0094114190999716,0.0180231102703541,0,0,0,0,0,0.00887142892993644,0.0359830171356315,0,0,0,0,0,0,0,0,0.00889040367711887,0,0,107986129,null,"non_coding"]
["LOC107986193",0,0,0,0,0,0.0260558515872829,0.0258877049740437,0.0680215661864071,0.083729176820437,0,0.0130472269768504,0.0279157922975546,0,0.0793601164279866,0.0129022796591433,0.0131541877236988,0.0400155966422109,0,0,0.0133410541656787,0.0130945290884843,0,0.0136962011269735,0,0.0137545124621769,0.026364645387318,0.0268502670045741,0,107986193,null,"non_coding"]
["LOC107986292",0,0,0,0,0,0,0,0,0,0,0,0.01104692147335,0,0,0.0102114579949961,0,0,0,0,0,0,0,0,0,0,0,0,0,107986292,null,"non_coding"]
["LOC107986325",0.00913770007974343,0,0,0,0,0,0,0,0,0,0,0,0.0173797435086851,0,0,0,0.00878534511591138,0.0422739602888562,0,0,0.00862463390472034,0,0.0090209216236304,0,0,0,0,0,107986325,null,"non_coding"]
["LOC107986434",0,0,0,0,0,0.00611136161686271,0,0,0,0,0,0,6.18906848752066E-3,0,0,0,0.00625706617381424,0.00602164089097663,0.0240594003055752,6.2582492138855E-3,0,0,0,0,0,0,0,0,107986434,null,"non_coding"]
["LOC107986450",0,0,0.0714395474810159,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,107986450,null,"non_coding"]
["LOC107986515",0,0,9.74300661988446E-3,0.00497643489624307,0.00507035203472278,0.00487261979153905,0,0,0,0.00499755348305006,0,0,0.00493457587590193,0.0148408764407678,0.00482562644421857,0,0,0,0,0,0,0,0.0153676913126331,0,0,0.00493036631256582,0,0.0048781446116387,107986515,null,"non_coding"]
["LOC107986625",0,0,0,0.0440418727188803,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,107986625,null,"non_coding"]
["LOC107986632",0.0712750270630436,0.0406766256902261,0.01338310930468,0.0273427596890352,0.0139293912323558,0.0803170591762412,0.0132997913179711,0.027956827731399,0.0716930154072401,0.054917589306071,0.0536240338784143,0.0430251595194199,0.0677819187607365,0.054361609807713,0.0927995270460119,0.0675795524779135,0.0137053242157263,0.118706890076058,0.0263495600385226,0.0274158310353397,0.0269092226535431,0.0406497241202307,0.267383742466675,0.0696337500202924,0.0565309734828341,0.0406344574200626,0.0551772276995109,0.0670067722302037,107986632,null,"non_coding"]
["LOC107986699",0,0.0136873524943667,0,0,0.00351534483122712,0,3.35645340748478E-3,0,0,0,0,0,0.0102636280563101,0,0,0,0,0,0.00332490444633966,0,0.00339552515933871,0.00341957508391638,0.021309263677867,0.00351467826740619,3.56666458214465E-3,0,0.00348125375616492,0,107986699,null,"non_coding"]
["LOC107986798",0.0416956152130597,0,0.00978633398884372,0,0,0.00978857688207477,0,0.0613298854293221,0,0,0.00980307889250594,0,0,0.00993791610077198,0.00969417222649478,0.00988344421776755,0.0200439041700994,0.00964487106358283,0,0.0100238469620702,0.0295158584906322,0.00990830475784434,0.0308720635611481,0,0,0.00990458352427666,0.0100870202609991,0,107986798,null,"non_coding"]
["LOC107986876",0.432915662236238,0.192161489743584,0.33869726572738,0.401351605617505,0.380724265605134,0.447182855440309,0.255807388791962,0.452816798630198,0.667696856339848,0.430851713424945,0.352847865319341,0.522658950650255,0.205849478120802,0.233881513716348,0.281826400927208,0.342058173810852,0.152614801397925,0.240336969094033,0.17338095139909,0.138766960620523,0.258785187558659,0.480086008368571,0.341906451259653,0.479339649229623,0.51504316793595,0.507328886921755,0.418924535250703,0.244194487491614,107986876,"uncharacterized LOC107986876","non_coding"]
["LOC107986942",0.0456498141155683,0.0506573049451052,0.114287145109341,0.0875616571921516,0.0371725639576416,0.0928795872485435,0.035492386935201,0.0522247429693098,0.0688762872828574,0.0586221627873442,0.100172359081085,0.0459275058714214,0.0651188526891885,0.0652822634291186,0.0495297503934543,0.0216414790407679,0.014629843687236,0.0351984710279779,0.0843810635611283,0.0512141342668349,0.0789922015828888,0.115711548873995,0.18777673433326,0.0520317216493712,0.0377152380948488,0.0578340457099169,0.0588993155968248,0.114442952334013,107986942,null,"non_coding"]
["LOC107986983",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.049563419204424,0,0,0,0,0,0.0489737150932685,0,0,107986983,null,"non_coding"]
["LOC107987060",0,0,0.0998321881465478,0.025495640321482,0,0,0,0.0260682254635481,0,0,0,0,0,0,0.148338043655121,0,0.0255589428914581,0,0.0245695355191549,0,0,0.0252691085836148,0,0,0,0,0.0771746579732065,0,107987060,null,"non_coding"]
["LOC107987119",0.399351336818416,0.126616459555913,0.0624875548028392,0.063833529101192,0.0650382193095922,0.25000750436588,0.0620985318081073,0,0,0,0.375566844681783,0,0.0632965967291619,0,0.0618990848832482,0,0.0639920199800953,0.12316857565642,0.0615148370775879,0.256016476483099,0.0628214074541358,0.0632663607500875,0.0657079476289127,0,0.131975396118567,0,0.0644074923331945,0.0625727438455877,107987119,null,"non_coding"]
["LOC107987142",0.0897996267679207,0.0698844632164303,0.030657128643428,0.0548055890375165,0.0159542573109538,0.084326425798758,0.0304662693910157,0.0880572340461587,0,0,0.0690965651557187,0.024639786993102,0.0698716217679573,0.0311319818735267,0.0455526275791317,0.0154806703495741,0.0392440461719239,0.0377674690648473,0.0679047792694755,0.0785029322953173,0.0154104603385372,0.0310392199924717,0.0483556368074676,0.0239268482050344,0.0647486801066259,0.0698120160339234,0.229093276030699,0.0460483850832157,107987142,"uncharacterized LOC107987142","non_coding"]
["LOC107987237",0.0140032286936327,0,0,0.0134299113173936,0,0,0,0,0,0,0.0131692270213092,0,0,0,0,0,0,0,0,0.01346580168515,0,0,0,0,0,0,0,0,107987237,null,"non_coding"]
["LOC112267864",0.918961883019651,0.097120579773002,0.191723179508711,0.391705746757314,0.199549081972612,0.0958835599130506,0.19052958622942,0.200251368333619,0.102705675859917,0.0983420088804738,0,0.308184002466754,0,0,0,0.0968128285876776,0.589017456634968,0.283427688300286,0.188738704669872,0.392752549150208,0.867363750645171,0,0,0.299266866564484,0.708617893932079,0.19403979540742,0.296420845397088,0.479961387451951,112267864,null,"non_coding"]
["LOC112267938",0,0,0,0,0,0.00562767003491449,0,0,0.0060280787965803,0,0,0,0,0,0.0167201841114154,0.00568221137108646,0,0,0.0110775940490987,0,0.005656440644492,0,0,0,0.00594153350689414,0,0.00579925175521205,0,112267938,null,"non_coding"]
["LOC112268044",0.0328734332137111,0.0312680890976494,0.0154313778628962,0.0472913035719197,0.080306337867027,0.0771745726129432,0.0153353081599289,0.0161177930609986,0.0165331087969623,0,0.0927466903025135,0.0496101077141604,0.0156311717532381,0.10969277881474,0.015286054498607,0.0311690082282279,0.0158029073731332,0.0304166299639331,0.0151911640344043,0,0,0.0156237049413325,0.0162266577986034,0,0.0162957425085426,0.0156178371913289,0,0.0154524154008921,112268044,null,"non_coding"]
["LOC112268055",0.135946330437105,0.0738900088186528,0.100281720694037,0.167631998252049,0.094886451082078,0.0547116566650836,0.0362390567468061,0.0380881565130228,0.185580572807401,0.0841716905979847,0.0365284755274068,0.117234260304356,0.0831109852585717,0.074061818549269,0.0180613324046941,0.0276209510956198,0.0280080346814898,0.0269542181957044,0.00897460699438873,0.0747022139594056,0.00916522695206232,0.0923014268868352,0.0671044782161267,0.170763226454662,0.144407516466191,0.0645867330534784,0.0845696360066621,0.127805280116888,112268055,null,"non_coding"]
["LOC112268109",0.00956572577545887,0,0.00449032286996981,0.00458704387615024,0,0.00449135199024935,0,0.00938012087297297,0.0192436468609071,0.0276390599834404,0.0224900301774488,0.048119574551232,0.00454846019789045,0.00911974841610942,0.0177921429224382,0.00906976108841267,0.0459843294746958,0,0.0132612716552997,0,0,0.00454628745631395,0.0188869544284667,0.0140181782776834,0.0663857785656739,0,4.62828857255922E-3,0,112268109,null,"non_coding"]
["LOC112268186",0,0,0,0.0182574712471629,0.0186020330652435,0.0178765959159925,0,0.0933375021893991,0.0191485158382896,0,0.0179030805197883,0,0.0181038994882136,0,0,0.0360996987954052,0.0183028023248154,0.0176141501203567,0.087971430142737,0,0.0539039619045021,0,0.0375871734317933,0,0,0.0723538220163261,0.018421634459706,0,112268186,null,"protein_coding"]
["LOC112268218",0.132658539543519,0.100944224645954,0.0871812095797486,0.0381681780796989,0.14259117471665,0.0249146258041785,0.0618846097005006,0.0260169100590923,0.0266873016013958,0.063883588445977,0.0499030748346857,0.200198269318954,0.0504628379435247,0.151768411633442,0,0.0880463126132029,0.089280205041127,0.0613721372303769,0.0367817554376325,0.140323991477879,0,0.0756580987316499,0.0654815915101123,0.142564137221663,0.118368680819925,0.0504197893578335,0.077022739355149,0,112268218,null,"non_coding"]
["LOC112268256",0.490113004277147,0.714807467129295,0.797568426756238,0.4230422064979,0.79819632789045,0.32216876130785,0.411543906255547,0.480603284000687,0.821645406879339,0.472041642626274,0.491651142128879,0.443784963552125,0.792358306327781,0.42053647150794,0.47099576406617,0.650582208109194,0.612578154900366,0.816271742304824,0.573765662196411,1.09970713762058,0.447174200332621,0.605631616998565,0.709645834392257,0.68631868065455,0.761258080338462,0.512265059875589,0.980164928779706,0.952243392704672,112268256,null,"non_coding"]
["LOC112268418",0.0532731526388203,0.0101343213676176,0.03000884548832,0,0.010411256450745,0.0200104820688105,0,0.0104478974782758,0.0214342280055479,0,0.0200401280759054,0.032158330692183,0,0.0101578857852159,0,0,0.0102437818545211,0,0,0.0614743120409022,0.0201127826236561,0.0202552380267078,0,0.0104092823152864,0,0,0,0,112268418,null,"non_coding"]
["LOC112268467",0,0,0.00922283516587095,0,0,0,0,0,0,0,0,0,0,0.00936568915327855,0,0,0,0,9.07926713426499E-3,0,0,0,0,0,0,0,0,0,112268467,null,"non_coding"]
["LOC254028",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.0124775781671408,254028,"uncharacterized LOC254028","non_coding"]
["LOC283194",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.00963086030646005,0.00981889617639143,0,0,0,0,0,0,0,0,0,0,0,0,283194,"uncharacterized LOC283194","non_coding"]
["LOC339666",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.0169033916929875,0,0,0,0,339666,"uncharacterized LOC339666","non_coding"]
["LOC440864",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.014802354768218,0,0,0,0,0,0,440864,null,"non_coding"]
["LOC645188",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.0368734348100362,0.0371346030489644,0,0,0,0,0,0,645188,"uncharacterized LOC645188","non_coding"]
["LOC729737",0.0640173178769018,0.140517901315706,0.124826710224524,0.288090488937696,0.125110056508952,0.124855318790687,0.105671871354132,0.101406063759735,0.0544861678292291,0.0284570226647187,0.0648357084808704,0.0842241994319079,0.0280984161585428,0.0704223174185139,0.0137390186578638,0.0466908782373893,0.160973714856761,0.214149966899887,0.150191048144311,0.203622896325957,0.106901974869432,0.327658262196745,0.102090992799397,0.153952410713479,0.0878791229178256,0.187162974013733,0.119131505274679,0.199069114737104,729737,"uncharacterized LOC729737","non_coding"]
["LOC84214",0.0200269058211315,0.0380978202972846,0.141014819995263,0.0576209047978813,0.156555594771975,0.0658219980383795,0.0186849222750991,0.068734124940663,0.0402887049435634,0.0192884772246991,0.0094170735572141,0.0402974624325027,0.00952270493139323,0.0859194128266594,0.0186249103846326,0.0284828232694802,0,0.0092650953084789,0.0370185869486227,0.077033189432136,0.0189024294345654,0.0475907802819195,0.00988548246274505,0.0489143466895887,0.0198551394606314,0.0380583253993751,0.0193796689412658,0.00941380433040975,84214,null,"non_coding"]
["LPAR6",2.09968228636487,2.22623063683104,1.86689622493431,1.94264513305895,2.53447906175524,2.18047782158283,2.01084008669345,2.47073028475955,2.00018421386022,1.14198390518521,2.06755355732033,1.66511145800135,3.01866037597013,2.26084517710263,2.65910811039685,2.6056291185522,2.04840435090923,1.36564745482969,2.41429881190079,1.78749648142452,2.31402978178997,2.27758898700315,3.88963953902285,2.55209847445506,1.91024181598421,2.06549027578702,2.71905856808692,2.07264150490591,10161,"lysophosphatidic acid receptor 6","protein_coding","hsa04072,hsa04151,hsa04080,hsa05200","Phospholipase D signaling pathway|PI3K-Akt signaling pathway|Neuroactive ligand-receptor interaction|Pathways in cancer","GO:0001835,GO:0005515,GO:0005886,GO:0007200,GO:0035025,GO:0070915","blastocyst hatching|protein binding|plasma membrane|phospholipase C-activating G protein-coupled receptor signaling pathway|positive regulation of Rho protein signal transduction|lysophosphatidic acid receptor activity","WP80,WP4900,WP455,WP3932,WP4172","Nucleotide GPCRs|Purinergic signaling|GPCRs, class A rhodopsin-like|Focal adhesion: PI3K-Akt-mTOR-signaling pathway|PI3K-Akt signaling pathway","R-HSA-162582,R-HSA-372790,R-HSA-373076,R-HSA-388396,R-HSA-416476,R-HSA-417957,R-HSA-418038,R-HSA-500792","Signal Transduction|Signaling by GPCR|Class A/1 (Rhodopsin-like receptors)|GPCR downstream signalling|G alpha (q) signalling events|P2Y receptors|Nucleotide-like (purinergic) receptors|GPCR ligand binding"]
["LRIG2",1.391331614669,1.57324270902914,1.49014937341166,1.28526325296569,1.2159821339991,1.38387794193443,1.11532737552945,1.14604177269137,1.31216276143634,1.07845668868245,1.13679608346676,1.2183817463117,1.57507065211256,1.24157063807158,1.35810957732111,1.25798312835903,1.07442543415254,1.06283627635142,1.06369511615251,1.26943176716829,1.14511975888299,1.19766684901664,1.44387639316535,1.04828668033686,1.1940073154909,1.09780149506743,1.09001795390548,0.941769144095992,9860,"leucine rich repeats and immunoglobulin like domains 2","protein_coding","hsa04360","Axon guidance","GO:0005102,GO:0005515,GO:0005615,GO:0005737,GO:0005886,GO:0006509,GO:0007605,GO:0010640,GO:0030426,GO:0031012,GO:0034394,GO:0048681,GO:0051045,GO:0060384,GO:0097708,GO:2000010,GO:2001222","signaling receptor binding|protein binding|extracellular space|cytoplasm|plasma membrane|membrane protein ectodomain proteolysis|sensory perception of sound|regulation of platelet-derived growth factor receptor signaling pathway|growth cone|extracellular matrix|protein localization to cell surface|negative regulation of axon regeneration|negative regulation of membrane protein ectodomain proteolysis|innervation|intracellular vesicle|positive regulation of protein localization to cell surface|regulation of neuron migration"]
["LRP12",11.5632188697548,8.95461506369367,6.16789846841592,6.18265201288807,12.0511601364163,7.81137825784109,6.07779805720783,6.71999315443172,9.84116496129098,6.26226098760484,5.44305991207381,8.06543861732088,10.4285408185765,5.88187527150971,7.66732851456397,8.26655067015989,8.25808393975658,6.52310961012719,6.50437204334665,8.04057228762789,8.26973947851309,5.85264415344574,8.02363380594261,8.5238422094849,8.61329374017083,5.37655995917846,7.12601670542548,5.40643942769997,29967,"LDL receptor related protein 12","protein_coding",null,null,"GO:0001764,GO:0005041,GO:0005515,GO:0005886,GO:0005905,GO:0006897,GO:0007165,GO:0016020,GO:0031175,GO:0040008","neuron migration|low-density lipoprotein particle receptor activity|protein binding|plasma membrane|clathrin-coated pit|endocytosis|signal transduction|membrane|neuron projection development|regulation of growth","WP5323","Fatty Acids and Lipoproteins Transport in Hepatocytes","R-HSA-1430728,R-HSA-196854,R-HSA-2187338,R-HSA-6806667,R-HSA-9709957,R-HSA-975634","Metabolism|Metabolism of vitamins and cofactors|Visual phototransduction|Metabolism of fat-soluble vitamins|Sensory Perception|Retinoid metabolism and transport"]
["LRRC20",5.37824426935833,5.1774225889839,5.0721701920659,4.80742658814086,5.02517272251465,5.49293160586879,5.23008882271717,5.2260899598387,6.93792627020447,7.89510275995933,7.2430748617201,6.42449399717312,5.49324035899512,6.73855406927029,6.67905677212191,5.96212963902703,5.10836839425191,5.31456812998511,5.83417616207377,5.10933424699204,5.02258856612293,6.20879818789738,5.07691922660826,5.92111852206909,5.67040761623355,6.28366122270539,5.14939648242561,5.78175547676296,55222,"leucine rich repeat containing 20","protein_coding",null,null,"GO:0005515","protein binding"]
["LRRC59",86.4283650979982,80.8277931779161,76.1156999581209,78.2130289301277,72.674112745409,69.3917313387407,71.2493326437676,72.6086430156664,81.2205043506548,78.7973541322202,77.9359885034181,82.0385814566499,71.1374626489868,66.7204150696635,67.3471715261753,64.2248237114938,86.9111618860912,92.8209933200754,85.6488377679185,83.7953928301518,80.1090735179208,87.6248981757579,81.9326772598457,83.5420083951788,83.75694787731,85.6798886604414,85.2745134820819,84.9659645493275,55379,"leucine rich repeat containing 59","protein_coding",null,null,"GO:0003723,GO:0005515,GO:0005635,GO:0005737,GO:0005783,GO:0005789,GO:0007165,GO:0016020,GO:0042645,GO:0043231,GO:0045296","RNA binding|protein binding|nuclear envelope|cytoplasm|endoplasmic reticulum|endoplasmic reticulum membrane|signal transduction|membrane|mitochondrial nucleoid|intracellular membrane-bounded organelle|cadherin binding","WP3888","VEGFA-VEGFR2 signaling"]
["LRRIQ3",0.093823506842881,0.08237697368698,0.0677575895452473,0.110747327597248,0.148099077704975,0.0881050542494216,0.154872241979255,0.0778487247176482,7.25951765114275E-3,0.0278043270087765,0.0882355839915032,0.0145221912808965,0.00686348639231876,0.0137614195644424,0.060407540669194,0.068429951130246,0.159594555853972,0.126878472513541,0.31350332631108,0.291488638887383,0.26566643393255,0.178365402596632,0.634121277719989,0.274988992248811,0.214658776819356,0.233159465003614,0.25840596321631,0.346034812350901,127255,"leucine rich repeats and IQ motif containing 3","protein_coding",null,null,"GO:0005515","protein binding"]
["LRRTM1",0,0,0,0,0,0,0,0,0,0,0.0183834387353302,0.0393331286687082,0,0,0,0,0,0,0,0,0,0,0,0.0381950460589914,0.00968999917114208,0,0,0,347730,"leucine rich repeat transmembrane neuronal 1","protein_coding",null,null,"GO:0002091,GO:0003674,GO:0005615,GO:0005783,GO:0007626,GO:0008150,GO:0009986,GO:0030424,GO:0030426,GO:0031012,GO:0031623,GO:0035418,GO:0035640,GO:0050808,GO:0051649,GO:0051965,GO:0060291,GO:0098982,GO:0099634","negative regulation of receptor internalization|molecular_function|extracellular space|endoplasmic reticulum|locomotory behavior|biological_process|cell surface|axon|growth cone|extracellular matrix|receptor internalization|protein localization to synapse|exploration behavior|synapse organization|establishment of localization in cell|positive regulation of synapse assembly|long-term synaptic potentiation|GABA-ergic synapse|postsynaptic specialization membrane",null,null,"R-HSA-112316,R-HSA-6794361,R-HSA-6794362","Neuronal System|Neurexins and neuroligins|Protein-protein interactions at synapses"]
["LSMEM2",0.399567904788491,0.0463482159437319,0.100644272106525,0.177584601024465,0.0571376980919411,0.173879948128655,0.0909251821485302,0.133790502053698,0.0686189764964307,0.0750897768458281,0.0458256724801525,0.19609683454139,0.0741435189452222,0.009291197048661,0.0725065202536963,0,0.0655883501965185,0.00901722218742777,0.099077584664011,0.121829966439218,0.0643885358396511,0.08337161422056,0.230904284509411,0.0380845759330073,0.212563409149753,0.12964047068435,0.113167177418411,0.128267338251801,132228,"leucine rich single-pass membrane protein 2","protein_coding",null,null,"GO:0005515,GO:0016020","protein binding|membrane"]
["LUZP2",0,0,0,0,0,0,0,0,0.00573847585756999,0.00824199693474447,0.0107304812766223,0.0258287544924517,0.0189889790187485,0,2.65281792356778E-3,0.00540922470839088,0.0137125757100204,2.63932662120901E-3,0.00263635016046805,8.22910102981389E-3,0,0.0108456618428721,0,0,0.00282804420254072,0,0.0138016054999702,0,338645,"leucine zipper protein 2","protein_coding",null,null,"GO:0005576","extracellular region"]
["LYRM7",2.93878661030629,2.23044696663438,2.02655007689092,1.64202746711098,3.04531343815029,1.94153801780521,1.88856822857796,1.81916727856185,2.38051245234795,1.22735381271375,1.23105485268341,2.11065654173725,2.7535393598822,1.54138852494781,1.88653361453141,1.9809034912566,2.23370118946439,1.83683382364604,1.96696139685862,3.02190215096277,2.22147770063937,1.98176610482727,3.28634829240987,2.53657421938367,2.40220049881516,1.61447100394943,2.76411604217204,1.73184330831673,90624,"LYR motif containing 7","protein_coding",null,null,"GO:0005515,GO:0005759,GO:0006457,GO:0031966,GO:0034551,GO:0044183,GO:0045333","protein binding|mitochondrial matrix|protein folding|mitochondrial membrane|mitochondrial respiratory chain complex III assembly|protein folding chaperone|cellular respiration","WP4921","Mitochondrial complex III assembly"]
["LYZL1",0,0,0,0,0,0,0,0,0,0,0,0.090931071976779,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,84569,"lysozyme like 1","protein_coding",null,null,"GO:0003796,GO:0005576,GO:0008152","lysozyme activity|extracellular region|metabolic process"]
["MACORIS",0,0,0,0,0,0,0,0,0,0,0,0.034548015563152,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.129131012776881,101929951,null,"non_coding"]
["MAGI2",0.501749410533252,0.613919820000008,0.508249276998774,0.400012536062143,0.59654285578351,0.582031387483495,0.52754944730889,0.460787018818731,0.737506417193142,0.611915907962775,0.573397919166022,0.573567137881996,0.805852525435481,0.675327013927732,0.84656888234549,0.842477474751802,0.386070682404548,0.329862593955661,0.42927097308307,0.461579870187826,0.415662822011481,0.454044511145855,0.504538436109864,0.439354733625125,0.418131868227607,0.340958995076531,0.444947281790086,0.435193018770471,9863,"membrane associated guanylate kinase%2C WW and PDZ domain containing 2","protein_coding","hsa04015,hsa04151","Rap1 signaling pathway|PI3K-Akt signaling pathway","GO:0001750,GO:0001917,GO:0002092,GO:0003402,GO:0005515,GO:0005634,GO:0005737,GO:0005770,GO:0005814,GO:0005886,GO:0005911,GO:0005923,GO:0007165,GO:0007399,GO:0008285,GO:0010976,GO:0014069,GO:0019902,GO:0030159,GO:0030336,GO:0030425,GO:0031697,GO:0032516,GO:0032926,GO:0032991,GO:0036057,GO:0038180,GO:0043113,GO:0045202,GO:0046332,GO:0048471,GO:0051898,GO:0060395,GO:0070699,GO:0072015,GO:0072583,GO:0097546,GO:1990090","photoreceptor outer segment|photoreceptor inner segment|positive regulation of receptor internalization|planar cell polarity pathway involved in axis elongation|protein binding|nucleus|cytoplasm|late endosome|centriole|plasma membrane|cell-cell junction|bicellular tight junction|signal transduction|nervous system development|negative regulation of cell population proliferation|positive regulation of neuron projection development|postsynaptic density|phosphatase binding|signaling receptor complex adaptor activity|negative regulation of cell migration|dendrite|beta-1 adrenergic receptor binding|positive regulation of phosphoprotein phosphatase activity|negative regulation of activin receptor signaling pathway|protein-containing complex|slit diaphragm|nerve growth factor signaling pathway|receptor clustering|synapse|SMAD binding|perinuclear region of cytoplasm|negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction|SMAD protein signal transduction|type II activin receptor binding|podocyte development|clathrin-dependent endocytosis|ciliary base|cellular response to nerve growth factor stimulus","WP3651","Pathways affected in adenoid cystic carcinoma","R-HSA-1500931,R-HSA-373753","Cell-Cell communication|Nephrin family interactions"]
["MAML2",3.91157986627233,4.41159115880199,3.13658621046854,3.00162838860846,4.76305030613878,3.87382816000852,3.4454174211111,3.32787408720051,4.80688998505657,4.29032719298299,2.96227779595948,3.4826545447087,5.39573529993247,3.69805585652039,5.15970983275372,5.15795782158219,3.10817530226923,2.91447082185421,2.70208066642731,3.83156245142248,3.61127891157361,2.84114517275024,4.28845006701653,3.90500978921035,3.41446183607139,2.83052362189953,3.46892278720412,2.61147693644471,84441,"mastermind like transcriptional coactivator 2","protein_coding","hsa04330,hsa04658,hsa05165","Notch signaling pathway|Th1 and Th2 cell differentiation|Human papillomavirus infection","GO:0003713,GO:0005515,GO:0005634,GO:0005654,GO:0007219,GO:0007221,GO:0016607,GO:0045944","transcription coactivator activity|protein binding|nucleus|nucleoplasm|Notch signaling pathway|positive regulation of transcription of Notch receptor target|nuclear speck|positive regulation of transcription by RNA polymerase II","WP61,WP3845","Notch signaling pathway|Canonical and non-canonical Notch signaling","R-HSA-1266738,R-HSA-157118,R-HSA-157118,R-HSA-162582,R-HSA-162582,R-HSA-1643685,R-HSA-186712,R-HSA-1912408,R-HSA-1912408,R-HSA-1912422,R-HSA-1912422,R-HSA-1980143,R-HSA-1980143,R-HSA-1980145,R-HSA-1980145,R-HSA-210744,R-HSA-2122947,R-HSA-2122947,R-HSA-212436,R-HSA-212436,R-HSA-2197563,R-HSA-2197563,R-HSA-2644602,R-HSA-2644603,R-HSA-2644606,R-HSA-2894858,R-HSA-2894862,R-HSA-350054,R-HSA-5663202,R-HSA-73857,R-HSA-73857,R-HSA-74160,R-HSA-74160,R-HSA-8878159,R-HSA-8878159,R-HSA-8941856,R-HSA-8941856,R-HSA-9012852,R-HSA-9012852,R-HSA-9013508,R-HSA-9013508,R-HSA-9013694,R-HSA-9013694,R-HSA-9013695,R-HSA-9013695,R-HSA-9758941,R-HSA-9793380","Developmental Biology|Signaling by NOTCH|Signaling by NOTCH|Signal Transduction|Signal Transduction|Disease|Regulation of beta-cell development|Pre-NOTCH Transcription and Translation|Pre-NOTCH Transcription and Translation|Pre-NOTCH Expression and Processing|Pre-NOTCH Expression and Processing|Signaling by NOTCH1|Signaling by NOTCH1|Signaling by NOTCH2|Signaling by NOTCH2|Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells|NOTCH1 Intracellular Domain Regulates Transcription|NOTCH1 Intracellular Domain Regulates Transcription|Generic Transcription Pathway|Generic Transcription Pathway|NOTCH2 intracellular domain regulates transcription|NOTCH2 intracellular domain regulates transcription|Signaling by NOTCH1 PEST Domain Mutants in Cancer|Signaling by NOTCH1 in Cancer|Constitutive Signaling by NOTCH1 PEST Domain Mutants|Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer|Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants|Notch-HLH transcription pathway|Diseases of signal transduction by growth factor receptors and second messengers|RNA Polymerase II Transcription|RNA Polymerase II Transcription|Gene expression (Transcription)|Gene expression (Transcription)|Transcriptional regulation by RUNX3|Transcriptional regulation by RUNX3|RUNX3 regulates NOTCH signaling|RUNX3 regulates NOTCH signaling|Signaling by NOTCH3|Signaling by NOTCH3|NOTCH3 Intracellular Domain Regulates Transcription|NOTCH3 Intracellular Domain Regulates Transcription|Signaling by NOTCH4|Signaling by NOTCH4|NOTCH4 Intracellular Domain Regulates Transcription|NOTCH4 Intracellular Domain Regulates Transcription|Gastrulation|Formation of paraxial mesoderm"]
["MAN2A1",12.2588527333819,11.3238508404146,8.63178729148594,8.25600953694203,16.0461676115435,11.7088527576795,8.64678353946777,9.79234116711158,13.7979840587887,8.96511447122338,7.16735810483002,10.7324510331576,18.2507493752894,10.4511569123955,10.7155283811825,14.4801722675144,8.51733086377593,6.99374668522991,5.65473332553687,9.2875941699292,9.13683203193973,7.78700142864428,7.93478688154502,8.86006589811353,9.12258735304682,7.00706921201783,6.4374927736087,6.26449957840265,4124,"mannosidase alpha class 2A member 1","protein_coding","hsa00510,hsa00513","N-Glycan biosynthesis|Various types of N-glycan biosynthesis","GO:0000139,GO:0001701,GO:0001889,GO:0004559,GO:0004572,GO:0005797,GO:0005801,GO:0006013,GO:0006491,GO:0006517,GO:0007005,GO:0007033,GO:0007585,GO:0016020,GO:0016799,GO:0019082,GO:0030246,GO:0042803,GO:0046872,GO:0048286,GO:0050769,GO:0060042,GO:0070062","Golgi membrane|in utero embryonic development|liver development|alpha-mannosidase activity|mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity|Golgi medial cisterna|cis-Golgi network|mannose metabolic process|N-glycan processing|protein deglycosylation|mitochondrion organization|vacuole organization|respiratory gaseous exchange by respiratory system|membrane|hydrolase activity, hydrolyzing N-glycosyl compounds|viral protein processing|carbohydrate binding|protein homodimerization activity|metal ion binding|lung alveolus development|positive regulation of neurogenesis|retina morphogenesis in camera-type eye|extracellular exosome","WP5153","N-glycan biosynthesis","R-HSA-1643685,R-HSA-199991,R-HSA-392499,R-HSA-446203,R-HSA-5653656,R-HSA-5663205,R-HSA-597592,R-HSA-6811438,R-HSA-6811442,R-HSA-948021,R-HSA-9679506,R-HSA-9694516,R-HSA-9694548,R-HSA-9694635,R-HSA-975576,R-HSA-975578,R-HSA-9772573,R-HSA-9824446","Disease|Membrane Trafficking|Metabolism of proteins|Asparagine N-linked glycosylation|Vesicle-mediated transport|Infectious disease|Post-translational protein modification|Intra-Golgi traffic|Intra-Golgi and retrograde Golgi-to-ER traffic|Transport to the Golgi and subsequent modification|SARS-CoV Infections|SARS-CoV-2 Infection|Maturation of spike protein|Translation of Structural Proteins|N-glycan antennae elongation in the medial/trans-Golgi|Reactions specific to the complex N-glycan synthesis pathway|Late SARS-CoV-2 Infection Events|Viral Infection Pathways"]
["MAP2K6",0.772924557413083,0.962905822313375,1.24245308804778,0.837103588321563,0.823427794441012,0.987817258403477,1.36839124326292,1.03706653107498,0.475955584668967,0.30503285389655,0.496413271171809,0.57089152089932,0.562936443530842,0.492457485420477,0.685504551834867,0.539806503786164,0.520184099754274,0.552940680664717,0.864193333250288,0.68706289002331,0.599634925265944,0.636136863895645,1.17248638628694,0.876683020256878,0.515847603962985,0.62694164261996,0.935843250899095,0.579538522357536,5608,"mitogen-activated protein kinase kinase 6","protein_coding","hsa04010,hsa04015,hsa04668,hsa04218,hsa04620,hsa04664,hsa04912,hsa04935,hsa04750,hsa04380,hsa05235,hsa05170,hsa05161,hsa05163,hsa05167,hsa05169,hsa05132,hsa05135,hsa05145,hsa05014,hsa05022,hsa05417,hsa05418,hsa04936","MAPK signaling pathway|Rap1 signaling pathway|TNF signaling pathway|Cellular senescence|Toll-like receptor signaling pathway|Fc epsilon RI signaling pathway|GnRH signaling pathway|Growth hormone synthesis, secretion and action|Inflammatory mediator regulation of TRP channels|Osteoclast differentiation|PD-L1 expression and PD-1 checkpoint pathway in cancer|Human immunodeficiency virus 1 infection|Hepatitis B|Human cytomegalovirus infection|Kaposi sarcoma-associated herpesvirus infection|Epstein-Barr virus infection|Salmonella infection|Yersinia infection|Toxoplasmosis|Amyotrophic lateral sclerosis|Pathways of neurodegeneration - multiple diseases|Lipid and atherosclerosis|Fluid shear stress and atherosclerosis|Alcoholic liver disease","GO:0000165,GO:0001649,GO:0001934,GO:0002931,GO:0004674,GO:0004708,GO:0004713,GO:0005515,GO:0005524,GO:0005654,GO:0005737,GO:0005829,GO:0005856,GO:0006915,GO:0007165,GO:0009410,GO:0016310,GO:0019901,GO:0022602,GO:0031098,GO:0032308,GO:0038066,GO:0042770,GO:0043065,GO:0043410,GO:0051403,GO:0051726,GO:0051770,GO:0060048,GO:0060348,GO:0070423,GO:0072709,GO:0090398,GO:0106310,GO:0120163,GO:1901796","MAPK cascade|osteoblast differentiation|positive regulation of protein phosphorylation|response to ischemia|protein serine/threonine kinase activity|MAP kinase kinase activity|protein tyrosine kinase activity|protein binding|ATP binding|nucleoplasm|cytoplasm|cytosol|cytoskeleton|apoptotic process|signal transduction|response to xenobiotic stimulus|phosphorylation|protein kinase binding|ovulation cycle process|stress-activated protein kinase signaling cascade|positive regulation of prostaglandin secretion|p38MAPK cascade|signal transduction in response to DNA damage|positive regulation of apoptotic process|positive regulation of MAPK cascade|stress-activated MAPK cascade|regulation of cell cycle|positive regulation of nitric-oxide synthase biosynthetic process|cardiac muscle contraction|bone development|nucleotide-binding oligomerization domain containing signaling pathway|cellular response to sorbitol|cellular senescence|protein serine kinase activity|negative regulation of cold-induced thermogenesis|regulation of signal transduction by p53 class mediator","WP185,WP4949,WP400,WP3879,WP4666,WP2032,WP2261,WP195,WP5036,WP2447,WP4239,WP1544,WP4496,WP382,WP75,WP3849,WP481,WP422,WP23,WP2637,WP4877,WP3611,WP231,WP722,WP4482,WP2795,WP2018,WP4566,WP5087,WP585,WP3888,WP3915,WP3931","Integrin-mediated cell adhesion|16p11.2 proximal deletion syndrome|p38 MAPK signaling pathway|4-hydroxytamoxifen, dexamethasone, and retinoic acids regulation of p27 expression|Hepatitis B infection|Thyroid stimulating hormone (TSH) signaling pathway|Glioblastoma signaling pathways|IL-1 signaling pathway|Angiotensin II receptor type 1 pathway|Amyotrophic lateral sclerosis (ALS)|Epithelial to mesenchymal transition in colorectal cancer|MicroRNAs in cardiomyocyte hypertrophy|Signal transduction through IL1R|MAPK signaling pathway|Toll-like receptor signaling pathway|MAPK and NFkB signaling pathways inhibited by Yersinia YopJ|Insulin signaling|MAPK cascade|B cell receptor signaling pathway|Interleukin-1 (IL-1) structural pathway|Host-pathogen interaction of human coronaviruses - MAPK signaling|Photodynamic therapy-induced AP-1 survival signaling|TNF-alpha signaling pathway|Serotonin HTR1 group and FOS pathway|Vitamin D in inflammatory diseases|Cardiac hypertrophic response|RANKL/RANK signaling pathway|Translation inhibitors in chronically activated PDGFRA cells|Pleural mesothelioma|Interferon type I signaling pathways|VEGFA-VEGFR2 signaling|Angiopoietin-like protein 8 regulatory pathway|Embryonic stem cell pluripotency pathways","R-HSA-1266738,R-HSA-1280215,R-HSA-1643685,R-HSA-166016,R-HSA-166058,R-HSA-166166,R-HSA-168138,R-HSA-168142,R-HSA-168164,R-HSA-168176,R-HSA-168179,R-HSA-168181,R-HSA-168188,R-HSA-168249,R-HSA-168256,R-HSA-168638,R-HSA-168643,R-HSA-168898,R-HSA-181438,R-HSA-212436,R-HSA-2262752,R-HSA-2559580,R-HSA-2559583,R-HSA-3700989,R-HSA-446652,R-HSA-448424,R-HSA-449147,R-HSA-450294,R-HSA-450302,R-HSA-5210891,R-HSA-525793,R-HSA-5339562,R-HSA-5633007,R-HSA-5663205,R-HSA-6804758,R-HSA-6811555,R-HSA-73857,R-HSA-74160,R-HSA-8953897,R-HSA-9020702,R-HSA-937061,R-HSA-975138,R-HSA-975155,R-HSA-975871,R-HSA-9824439","Developmental Biology|Cytokine Signaling in Immune system|Disease|Toll Like Receptor 4 (TLR4) Cascade|MyD88:MAL(TIRAP) cascade initiated on plasma membrane|MyD88-independent TLR4 cascade |Toll Like Receptor 9 (TLR9) Cascade|Toll Like Receptor 10 (TLR10) Cascade|Toll Like Receptor 3 (TLR3) Cascade|Toll Like Receptor 5 (TLR5) Cascade|Toll Like Receptor TLR1:TLR2 Cascade|Toll Like Receptor 7/8 (TLR7/8) Cascade|Toll Like Receptor TLR6:TLR2 Cascade|Innate Immune System|Immune System|NOD1/2 Signaling Pathway|Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways|Toll-like Receptor Cascades|Toll Like Receptor 2 (TLR2) Cascade|Generic Transcription Pathway|Cellular responses to stress|Oxidative Stress Induced Senescence|Cellular Senescence|Transcriptional Regulation by TP53|Interleukin-1 family signaling|Interleukin-17 signaling|Signaling by Interleukins|MAP kinase activation|activated TAK1 mediates p38 MAPK activation|Uptake and function of anthrax toxins|Myogenesis|Uptake and actions of bacterial toxins|Regulation of TP53 Activity|Infectious disease|Regulation of TP53 Activity through Acetylation|PI5P Regulates TP53 Acetylation|RNA Polymerase II Transcription|Gene expression (Transcription)|Cellular responses to stimuli|Interleukin-1 signaling|TRIF(TICAM1)-mediated TLR4 signaling |TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation|MyD88 dependent cascade initiated on endosome|MyD88 cascade initiated on plasma membrane|Bacterial Infection Pathways"]
["MAP4K1-AS1",0,0,0,0,0.0511465608162812,0,0.0488347677325892,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.0516732403683682,0,0,0,0,0,105372397,"MAP4K1 antisense RNA 1","non_coding"]
["MAPKAPK3",18.4934188712223,16.4698027914797,18.8992726001055,20.0872547279904,16.1326968610711,17.7160282395645,19.3958139194988,19.2218148274889,12.9559645761491,15.5757056790099,15.0621976117036,14.1091231360679,11.9443850993574,14.195808589945,13.6462420198747,14.0276562224058,12.6585756747257,13.689047320786,16.5716464215925,13.493927556279,13.2445775805458,13.7747659773885,12.7671260131865,13.5739449708579,12.289042528518,14.4527224476467,15.9427170370125,16.237747669467,7867,"MAPK activated protein kinase 3","protein_coding","hsa04010,hsa04370","MAPK signaling pathway|VEGF signaling pathway","GO:0000165,GO:0002224,GO:0004674,GO:0004683,GO:0004708,GO:0005515,GO:0005516,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0007165,GO:0009931,GO:0018105,GO:0032496,GO:0034097,GO:0035556,GO:0044351,GO:0046777,GO:0048010,GO:0051019,GO:0106310","MAPK cascade|toll-like receptor signaling pathway|protein serine/threonine kinase activity|calmodulin-dependent protein kinase activity|MAP kinase kinase activity|protein binding|calmodulin binding|ATP binding|nucleus|nucleoplasm|cytoplasm|cytosol|signal transduction|calcium-dependent protein serine/threonine kinase activity|peptidyl-serine phosphorylation|response to lipopolysaccharide|response to cytokine|intracellular signal transduction|macropinocytosis|protein autophosphorylation|vascular endothelial growth factor receptor signaling pathway|mitogen-activated protein kinase binding|protein serine kinase activity","WP4746,WP382,WP314,WP5322,WP722","Thyroid hormones production and peripheral downstream signaling effects|MAPK signaling pathway|Fas ligand pathway and stress induction of heat shock proteins|CKAP4 signaling pathway map|Serotonin HTR1 group and FOS pathway","R-HSA-1280215,R-HSA-162582,R-HSA-166016,R-HSA-166058,R-HSA-166166,R-HSA-166520,R-HSA-167044,R-HSA-168138,R-HSA-168142,R-HSA-168164,R-HSA-168176,R-HSA-168179,R-HSA-168181,R-HSA-168188,R-HSA-168249,R-HSA-168256,R-HSA-168898,R-HSA-171007,R-HSA-181438,R-HSA-187037,R-HSA-187687,R-HSA-194138,R-HSA-2262752,R-HSA-2559580,R-HSA-2559583,R-HSA-4420097,R-HSA-448424,R-HSA-449147,R-HSA-450294,R-HSA-450302,R-HSA-8953897,R-HSA-9006934,R-HSA-937061,R-HSA-975138,R-HSA-975155,R-HSA-975871","Cytokine Signaling in Immune system|Signal Transduction|Toll Like Receptor 4 (TLR4) Cascade|MyD88:MAL(TIRAP) cascade initiated on plasma membrane|MyD88-independent TLR4 cascade |Signaling by NTRKs|Signalling to RAS|Toll Like Receptor 9 (TLR9) Cascade|Toll Like Receptor 10 (TLR10) Cascade|Toll Like Receptor 3 (TLR3) Cascade|Toll Like Receptor 5 (TLR5) Cascade|Toll Like Receptor TLR1:TLR2 Cascade|Toll Like Receptor 7/8 (TLR7/8) Cascade|Toll Like Receptor TLR6:TLR2 Cascade|Innate Immune System|Immune System|Toll-like Receptor Cascades|p38MAPK events|Toll Like Receptor 2 (TLR2) Cascade|Signaling by NTRK1 (TRKA)|Signalling to ERKs|Signaling by VEGF|Cellular responses to stress|Oxidative Stress Induced Senescence|Cellular Senescence|VEGFA-VEGFR2 Pathway|Interleukin-17 signaling|Signaling by Interleukins|MAP kinase activation|activated TAK1 mediates p38 MAPK activation|Cellular responses to stimuli|Signaling by Receptor Tyrosine Kinases|TRIF(TICAM1)-mediated TLR4 signaling |TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation|MyD88 dependent cascade initiated on endosome|MyD88 cascade initiated on plasma membrane"]
["MARK3",18.5971786436227,21.1856656571055,19.0768541270493,19.1301935242058,18.8208732484243,18.373995507587,18.1649800700254,18.3460166461064,19.5762984493824,19.2113766725838,19.6494703095128,21.2385239741459,17.7566651936314,19.2372654232447,21.7335135462684,19.3934172745294,19.2493837695311,19.9464097718116,18.4766577242131,18.2061177513961,18.4960821050442,19.1657695669808,18.0871350114292,18.9192953297872,19.3765619442378,18.7334553016743,17.3034336041701,17.735867768017,4140,"microtubule affinity regulating kinase 3","protein_coding",null,null,"GO:0004674,GO:0005515,GO:0005524,GO:0005737,GO:0005829,GO:0005886,GO:0006468,GO:0018105,GO:0030425,GO:0032092,GO:0035331,GO:0035556,GO:0036289,GO:0048156,GO:0050321,GO:0070062,GO:0106310,GO:1900181","protein serine/threonine kinase activity|protein binding|ATP binding|cytoplasm|cytosol|plasma membrane|protein phosphorylation|peptidyl-serine phosphorylation|dendrite|positive regulation of protein binding|negative regulation of hippo signaling|intracellular signal transduction|peptidyl-serine autophosphorylation|tau protein binding|tau-protein kinase activity|extracellular exosome|protein serine kinase activity|negative regulation of protein localization to nucleus","WP5090","Complement system in neuronal development and plasticity","R-HSA-162582,R-HSA-1643685,R-HSA-5663202,R-HSA-5673000,R-HSA-5673001,R-HSA-5674135,R-HSA-5675221,R-HSA-5683057,R-HSA-5684996,R-HSA-6802946,R-HSA-6802948,R-HSA-6802949,R-HSA-6802952,R-HSA-6802955,R-HSA-6802957,R-HSA-9649948,R-HSA-9656223","Signal Transduction|Disease|Diseases of signal transduction by growth factor receptors and second messengers|RAF activation|RAF/MAP kinase cascade|MAP2K and MAPK activation|Negative regulation of MAPK pathway|MAPK family signaling cascades|MAPK1/MAPK3 signaling|Signaling by moderate kinase activity BRAF mutants|Signaling by high-kinase activity BRAF mutants|Signaling by RAS mutants|Signaling by BRAF and RAF1 fusions|Paradoxical activation of RAF signaling by kinase inactive BRAF|Oncogenic MAPK signaling|Signaling downstream of RAS mutants|Signaling by RAF1 mutants"]
["MAST1",0.0666545606476236,0.0898160234949996,0.0260740363642591,0.138505473199165,0.0759873693561483,0.0521600243499801,0.0207293677166976,0.0871483391552864,0.117329541926103,0.171191694008292,0.0888034111420453,0.0558833550733038,0.0633878961680871,0.0635469632060903,0.149805223975633,0.0842648646104163,0.197593327715171,0.102788529035339,0.118073502447503,0.181606577435208,0.17825072751771,0.0316788082882161,0.0219342417388911,0.146519281878675,0.0715897857577021,0.0897229138459202,0.026875164223103,0.104438331990369,22983,"microtubule associated serine/threonine kinase 1","protein_coding",null,null,"GO:0000287,GO:0004674,GO:0005515,GO:0005524,GO:0005737,GO:0005856,GO:0005886,GO:0006468,GO:0007010,GO:0007420,GO:0008017,GO:0018105,GO:0030424,GO:0030425,GO:0035556,GO:0043005,GO:0043025,GO:0106310","magnesium ion binding|protein serine/threonine kinase activity|protein binding|ATP binding|cytoplasm|cytoskeleton|plasma membrane|protein phosphorylation|cytoskeleton organization|brain development|microtubule binding|peptidyl-serine phosphorylation|axon|dendrite|intracellular signal transduction|neuron projection|neuronal cell body|protein serine kinase activity"]
["MB21D2",0.721648595915747,0.778486606133446,0.677509531505808,0.936871139648739,0.601969806538341,0.652872192473583,0.862141712419119,0.517790021940016,0.557688802122803,0.339043948344042,0.355887289157321,0.256769694513599,0.301294280219125,0.218147478599903,0.212797049892459,0.375493438988446,0.829201199154417,0.977145409223318,0.894706494223488,0.609324229044006,0.930322899810513,1.00383451924722,0.729802278268237,0.816804115076423,0.497331377635834,0.59371236126619,0.8260686700325,0.554329547584075,151963,"Mab-21 domain containing 2","protein_coding",null,null,"GO:0005515,GO:0016779,GO:0044877,GO:0045296","protein binding|nucleotidyltransferase activity|protein-containing complex binding|cadherin binding"]
["MCF2L2",0.00424139961218521,0.0100856868303329,0.00597296664978755,0,0.0062167757423613,0.0159315615243775,0.00593578130334752,0.0041591032365727,0.0127988191772566,0.0204250573081937,0.0119663733849517,0.0149352014412336,0.0221844338312026,0.0202182763249125,0.0138056726964053,0.0160859644384529,0.0101946220171263,0.0196220884040793,0.00783998395607682,0.0224324089908781,0.00800650460826843,0.0060474099843723,0.031403963641385,0.00621559694540349,0.0105125551545943,0.0141053238105936,0.0061564867583063,0.00199370319073739,23101,"MCF.2 cell line derived transforming sequence-like 2","protein_coding",null,null,"GO:0005085,GO:0005737,GO:0048583","guanyl-nucleotide exchange factor activity|cytoplasm|regulation of response to stimulus"]
["MCM4",24.2076877842585,20.2455263918571,9.95216761108933,16.5090190366208,17.9869282131541,14.2621861199915,7.6629558524765,11.5146933289777,18.4958713539975,19.7544569183798,14.1073532042238,18.5712948619075,13.3084200367995,5.80667347499927,4.92022165862296,5.43227023251949,25.2220150937822,25.5684608499595,18.735817455625,25.5307957931319,25.4731184033421,23.3414711467227,20.121211023622,26.6002258418829,25.7527336803742,23.7434487421991,19.2734564808979,23.2554043707786,4173,"minichromosome maintenance complex component 4","protein_coding","hsa03030,hsa04110","DNA replication|Cell cycle","GO:0000727,GO:0000781,GO:0003678,GO:0003697,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0006260,GO:0006268,GO:0006271,GO:0016020,GO:0016887,GO:0017116,GO:0030174,GO:0042555,GO:0071162,GO:1902975","double-strand break repair via break-induced replication|chromosome, telomeric region|DNA helicase activity|single-stranded DNA binding|protein binding|ATP binding|nucleus|nucleoplasm|DNA replication|DNA unwinding involved in DNA replication|DNA strand elongation involved in DNA replication|membrane|ATP hydrolysis activity|single-stranded DNA helicase activity|regulation of DNA-templated DNA replication initiation|MCM complex|CMG complex|mitotic DNA replication initiation","WP466,WP179,WP2446,WP4352,WP2361,WP45","DNA replication|Cell cycle|Retinoblastoma gene in cancer|Ciliary landscape|Gastric cancer network 1|G1 to S cell cycle control","R-HSA-1640170,R-HSA-1640170,R-HSA-176187,R-HSA-176974,R-HSA-453279,R-HSA-68867,R-HSA-68867,R-HSA-68949,R-HSA-68962,R-HSA-69002,R-HSA-69002,R-HSA-69052,R-HSA-69190,R-HSA-69206,R-HSA-69239,R-HSA-69239,R-HSA-69242,R-HSA-69242,R-HSA-69278,R-HSA-69278,R-HSA-69306,R-HSA-69306,R-HSA-69481,R-HSA-69620","Cell Cycle|Cell Cycle|Activation of ATR in response to replication stress|Unwinding of DNA|Mitotic G1 phase and G1/S transition|Assembly of the pre-replicative complex|Assembly of the pre-replicative complex|Orc1 removal from chromatin|Activation of the pre-replicative complex|DNA Replication Pre-Initiation|DNA Replication Pre-Initiation|Switching of origins to a post-replicative state|DNA strand elongation|G1/S Transition|Synthesis of DNA|Synthesis of DNA|S Phase|S Phase|Cell Cycle, Mitotic|Cell Cycle, Mitotic|DNA Replication|DNA Replication|G2/M Checkpoints|Cell Cycle Checkpoints"]
["MDK",87.2567482044265,95.1179295499472,99.7045793607046,113.742272470043,92.8004815550247,110.525187100522,109.532326366492,123.164082666683,195.273718572112,266.945211195195,273.770429354986,233.9414123254,202.095959234323,246.783903429831,224.44865336947,222.579547429951,133.056596394774,133.216652202949,128.372358337403,121.159909849258,132.126212064341,131.877599888178,106.291160010859,120.042962180974,123.429236288285,143.443209130171,117.268179787216,144.222302627317,4192,"midkine","protein_coding",null,null,"GO:0001662,GO:0002232,GO:0002286,GO:0002690,GO:0005515,GO:0005576,GO:0007010,GO:0007162,GO:0007165,GO:0007399,GO:0007614,GO:0008083,GO:0008201,GO:0009611,GO:0010667,GO:0010718,GO:0010759,GO:0010838,GO:0010976,GO:0010996,GO:0021542,GO:0021681,GO:0021987,GO:0030154,GO:0030279,GO:0030325,GO:0030335,GO:0030421,GO:0032330,GO:0032735,GO:0035374,GO:0035556,GO:0042246,GO:0043524,GO:0044849,GO:0045582,GO:0045590,GO:0045785,GO:0045893,GO:0046850,GO:0048477,GO:0048714,GO:0050729,GO:0050795,GO:0051781,GO:0061036,GO:0062023,GO:0071673,GO:0090023,GO:0090090,GO:0106015,GO:0106016,GO:0106091,GO:1900026,GO:1903039,GO:1904036,GO:1904399,GO:1904996,GO:1905555,GO:1905564,GO:1905653,GO:2000179,GO:2000347,GO:2000391,GO:2001224","behavioral fear response|leukocyte chemotaxis involved in inflammatory response|T cell activation involved in immune response|positive regulation of leukocyte chemotaxis|protein binding|extracellular region|cytoskeleton organization|negative regulation of cell adhesion|signal transduction|nervous system development|short-term memory|growth factor activity|heparin binding|response to wounding|negative regulation of cardiac muscle cell apoptotic process|positive regulation of epithelial to mesenchymal transition|positive regulation of macrophage chemotaxis|positive regulation of keratinocyte proliferation|positive regulation of neuron projection development|response to auditory stimulus|dentate gyrus development|cerebellar granular layer development|cerebral cortex development|cell differentiation|negative regulation of ossification|adrenal gland development|positive regulation of cell migration|defecation|regulation of chondrocyte differentiation|positive regulation of interleukin-12 production|chondroitin sulfate binding|intracellular signal transduction|tissue regeneration|negative regulation of neuron apoptotic process|estrous cycle|positive regulation of T cell differentiation|negative regulation of regulatory T cell differentiation|positive regulation of cell adhesion|positive regulation of DNA-templated transcription|regulation of bone remodeling|oogenesis|positive regulation of oligodendrocyte differentiation|positive regulation of inflammatory response|regulation of behavior|positive regulation of cell division|positive regulation of cartilage development|collagen-containing extracellular matrix|positive regulation of smooth muscle cell chemotaxis|positive regulation of neutrophil chemotaxis|negative regulation of canonical Wnt signaling pathway|negative regulation of inflammatory response to wounding|positive regulation of inflammatory response to wounding|glial cell projection elongation|positive regulation of substrate adhesion-dependent cell spreading|positive regulation of leukocyte cell-cell adhesion|negative regulation of epithelial cell apoptotic process|heparan sulfate binding|positive regulation of leukocyte adhesion to vascular endothelial cell|positive regulation of blood vessel branching|positive regulation of vascular endothelial cell proliferation|positive regulation of artery morphogenesis|positive regulation of neural precursor cell proliferation|positive regulation of hepatocyte proliferation|positive regulation of neutrophil extravasation|positive regulation of neuron migration","WP5300,WP5087","TROP2 regulatory signaling|Pleural mesothelioma","R-HSA-157118,R-HSA-162582,R-HSA-162582,R-HSA-1980145,R-HSA-201556,R-HSA-201556,R-HSA-2979096,R-HSA-9006934,R-HSA-9006934","Signaling by NOTCH|Signal Transduction|Signal Transduction|Signaling by NOTCH2|Signaling by ALK|Signaling by ALK|NOTCH2 Activation and Transmission of Signal to the Nucleus|Signaling by Receptor Tyrosine Kinases|Signaling by Receptor Tyrosine Kinases"]
["MEAK7",5.7906635116733,4.89096348142633,4.62604767839333,5.22690195707597,5.22979560446277,4.94697426578574,3.70914304755158,4.70828160948916,4.91408524374036,4.48509014432338,4.39261083227218,4.78370709177752,4.80575329312123,4.67545837622689,4.56512447729907,4.5923166078481,6.97155229615242,6.41566071380506,6.46017595752152,6.29083934186725,6.10853095313294,6.46226942759484,6.26483253488058,6.79243059441494,6.24061777673521,5.87016565064289,6.67816615373409,5.89133702073271,57707,"MTOR associated protein%2C eak-7 homolog","protein_coding",null,null,"GO:0005515,GO:0005654,GO:0005730,GO:0005737,GO:0005765,GO:0005829,GO:0016020,GO:0030334,GO:0031667,GO:0031929,GO:0032868,GO:0042127,GO:0043200,GO:0150032,GO:1900408","protein binding|nucleoplasm|nucleolus|cytoplasm|lysosomal membrane|cytosol|membrane|regulation of cell migration|response to nutrient levels|TOR signaling|response to insulin|regulation of cell population proliferation|response to amino acid|positive regulation of protein localization to lysosome|negative regulation of cellular response to oxidative stress"]
["MEF2C-AS2",0,0,0.109319480324621,0,0.341345297888356,0,0.0543194500697267,0.0570911028510536,0.234248798505556,0,0,0.175724787583635,0.16610230027199,0,0.108289975713673,0.110404262406682,0,0,0,0.223945298003574,0.32971062659514,0,0.689720573383404,0,0.346328523291704,0.276601004252478,0.0563391671597058,0,109729137,"MEF2C antisense RNA 2","non_coding"]
["MEN1",10.8768185546235,12.5344252817533,12.8952644576028,12.1792241227972,10.0278174936565,12.7975573889463,11.5681563728159,11.7940198789829,10.2217742214262,15.0116000109317,13.7507049535465,11.7194892136349,10.493273559565,12.4068664733939,10.6404231531608,10.4348418851023,9.93521915719597,12.1666519855732,12.4963836317795,11.6551297300312,11.2036783938055,11.2490675577594,9.70071933612163,9.4184963583253,10.2592326749433,12.0461057293119,10.4353968456972,11.4952533699679,4221,"menin 1","protein_coding","hsa05202,hsa04934","Transcriptional misregulation in cancer|Cushing syndrome","GO:0000122,GO:0000165,GO:0000400,GO:0000403,GO:0000781,GO:0000785,GO:0000976,GO:0001933,GO:0002076,GO:0003682,GO:0003690,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005788,GO:0005829,GO:0006281,GO:0006357,GO:0006974,GO:0008285,GO:0009411,GO:0010332,GO:0016363,GO:0017053,GO:0030511,GO:0030674,GO:0032154,GO:0032991,GO:0035097,GO:0043433,GO:0044665,GO:0045064,GO:0045668,GO:0045736,GO:0045786,GO:0045815,GO:0045892,GO:0045944,GO:0046329,GO:0051219,GO:0051974,GO:0070412,GO:0071339","negative regulation of transcription by RNA polymerase II|MAPK cascade|four-way junction DNA binding|Y-form DNA binding|chromosome, telomeric region|chromatin|transcription cis-regulatory region binding|negative regulation of protein phosphorylation|osteoblast development|chromatin binding|double-stranded DNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|endoplasmic reticulum lumen|cytosol|DNA repair|regulation of transcription by RNA polymerase II|DNA damage response|negative regulation of cell population proliferation|response to UV|response to gamma radiation|nuclear matrix|transcription repressor complex|positive regulation of transforming growth factor beta receptor signaling pathway|protein-macromolecule adaptor activity|cleavage furrow|protein-containing complex|histone methyltransferase complex|negative regulation of DNA-binding transcription factor activity|MLL1/2 complex|T-helper 2 cell differentiation|negative regulation of osteoblast differentiation|negative regulation of cyclin-dependent protein serine/threonine kinase activity|negative regulation of cell cycle|transcription initiation-coupled chromatin remodeling|negative regulation of DNA-templated transcription|positive regulation of transcription by RNA polymerase II|negative regulation of JNK cascade|phosphoprotein binding|negative regulation of telomerase activity|R-SMAD binding|MLL1 complex","WP5352","10q11.21q11.23 copy number variation syndrome","R-HSA-162582,R-HSA-170834,R-HSA-194315,R-HSA-195258,R-HSA-195721,R-HSA-201681,R-HSA-201722,R-HSA-212165,R-HSA-212436,R-HSA-2173793,R-HSA-2173796,R-HSA-3769402,R-HSA-381426,R-HSA-392499,R-HSA-5626467,R-HSA-597592,R-HSA-73857,R-HSA-74160,R-HSA-8957275,R-HSA-9006936,R-HSA-9716542,R-HSA-9772755","Signal Transduction|Signaling by TGF-beta Receptor Complex|Signaling by Rho GTPases|RHO GTPase Effectors|Signaling by WNT|TCF dependent signaling in response to WNT|Formation of the beta-catenin:TCF transactivating complex|Epigenetic regulation of gene expression|Generic Transcription Pathway|Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer|SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription|Deactivation of the beta-catenin transactivating complex|Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)|Metabolism of proteins|RHO GTPases activate IQGAPs|Post-translational protein modification|RNA Polymerase II Transcription|Gene expression (Transcription)|Post-translational protein phosphorylation|Signaling by TGFB family members|Signaling by Rho GTPases, Miro GTPases and RHOBTB3|Formation of WDR5-containing histone-modifying complexes"]
["MESP1",0.147840302935519,0.140620656636595,0.0925318453204749,0.378099879868121,0.240772201283225,0.671009629519484,0.0919557783630108,0.459077177130455,0.371768259968256,0.261046795053835,0.301243058691284,0.198319504329611,0.234324695386751,0.281895258171075,0.0916604364815924,0.233625107377942,0.639627731702323,0.569964272633117,0.364365762580228,0.473887902082518,0.418617971060923,0.351319142190842,0.291901851441056,0.385162475432169,0.219858463826406,0.913086715500364,0.500718210506233,0.509618964958123,55897,"mesoderm posterior bHLH transcription factor 1","protein_coding",null,null,"GO:0000785,GO:0000976,GO:0000978,GO:0000981,GO:0001228,GO:0001707,GO:0001947,GO:0003007,GO:0003139,GO:0003143,GO:0003210,GO:0003211,GO:0003236,GO:0003241,GO:0003259,GO:0003700,GO:0005515,GO:0005634,GO:0006357,GO:0007219,GO:0007369,GO:0008078,GO:0010467,GO:0022008,GO:0023019,GO:0032525,GO:0035481,GO:0042662,GO:0042664,GO:0045446,GO:0045747,GO:0045892,GO:0045893,GO:0045944,GO:0046983,GO:0048368,GO:0051155,GO:0055007,GO:0060913,GO:0060921,GO:0060947,GO:0060975,GO:0070368,GO:0090082","chromatin|transcription cis-regulatory region binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|mesoderm formation|heart looping|heart morphogenesis|secondary heart field specification|embryonic heart tube morphogenesis|cardiac atrium formation|cardiac ventricle formation|sinus venosus morphogenesis|growth involved in heart morphogenesis|cardioblast anterior-lateral migration|DNA-binding transcription factor activity|protein binding|nucleus|regulation of transcription by RNA polymerase II|Notch signaling pathway|gastrulation|mesodermal cell migration|gene expression|neurogenesis|signal transduction involved in regulation of gene expression|somite rostral/caudal axis specification|positive regulation of Notch signaling pathway involved in heart induction|negative regulation of mesodermal cell fate specification|negative regulation of endodermal cell fate specification|endothelial cell differentiation|positive regulation of Notch signaling pathway|negative regulation of DNA-templated transcription|positive regulation of DNA-templated transcription|positive regulation of transcription by RNA polymerase II|protein dimerization activity|lateral mesoderm development|positive regulation of striated muscle cell differentiation|cardiac muscle cell differentiation|cardiac cell fate determination|sinoatrial node cell differentiation|cardiac vascular smooth muscle cell differentiation|cardioblast migration to the midline involved in heart field formation|positive regulation of hepatocyte differentiation|positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway","WP2406","Cardiac progenitor differentiation"]
["METTL27",4.00544957381067,3.52520334984771,5.40295894431039,3.42198957244007,3.98143872861496,3.912638793241,5.54114055391044,4.83065811501972,3.51953318608605,4.10164279566382,4.43800701390621,4.95620933770615,3.13050589203194,4.63072943528764,3.76786231466945,3.23029106624913,4.05018664459843,4.81367195979171,6.27624693411172,5.8661332917482,3.41118633046219,5.6234664036489,4.97691410328473,5.10517073141941,4.45036588747388,4.96516518325186,5.47986205051765,5.38868347831622,155368,"methyltransferase like 27","protein_coding",null,null,"GO:0005515,GO:0008152,GO:0008757","protein binding|metabolic process|S-adenosylmethionine-dependent methyltransferase activity","WP4932","7q11.23 copy number variation syndrome"]
["MFSD12",14.7042313796091,14.5494830237898,13.4486603529323,15.7440699118892,14.3321863818434,15.3634889655119,12.4670317102702,12.9670494699739,14.3343699202224,20.7395295679793,16.4218633450842,15.1660807145946,12.5667537769802,13.0394056409507,13.4424923062106,12.5204611356603,10.4627941215653,11.8158113515917,11.7426185648983,11.4703159513919,11.406840729391,12.6311191503727,8.9527924524255,9.62831813746084,10.7065209997423,11.404184391669,9.32184030385736,11.996760924834,126321,"major facilitator superfamily domain containing 12","protein_coding",null,null,"GO:0005215,GO:0005764,GO:0005765,GO:0005770,GO:0008643,GO:0015293,GO:0033162,GO:0033229,GO:0042438,GO:0042470,GO:0043474,GO:0048021,GO:0048022,GO:0071702,GO:1903712","transporter activity|lysosome|lysosomal membrane|late endosome|carbohydrate transport|symporter activity|melanosome membrane|cysteine transmembrane transporter activity|melanin biosynthetic process|melanosome|pigment metabolic process involved in pigmentation|regulation of melanin biosynthetic process|negative regulation of melanin biosynthetic process|organic substance transport|cysteine transmembrane transport"]
["MFSD4B",0.368120530962284,0.377741233781088,0.360927107660395,0.325222490849564,0.421731177884399,0.315032160521587,0.287620848636945,0.375203572877765,0.404936041089676,0.340574949018956,0.433171446489685,0.499894562225252,0.441479391111974,0.420112115835379,0.391257182349815,0.436722572066956,0.37484730169975,0.49832936841011,0.578214639129901,0.392356229726242,0.46383878742877,0.399899579958172,0.486941642166231,0.453540798517638,0.530365302767097,0.337719312935134,0.389564590358393,0.376762424345733,91749,"major facilitator superfamily domain containing 4B","protein_coding",null,null,"GO:0005355,GO:0005515,GO:0006814,GO:0015293,GO:0016324,GO:1904659","glucose transmembrane transporter activity|protein binding|sodium ion transport|symporter activity|apical plasma membrane|glucose transmembrane transport",null,null,"R-HSA-189200,R-HSA-382551,R-HSA-425407","Cellular hexose transport|Transport of small molecules|SLC-mediated transmembrane transport"]
["MIA2",1.50249574840618,1.49504168501245,1.7255086155784,1.50212950396753,1.72822146106597,1.44476133262651,1.4302650839575,1.47062430228717,1.57544000527203,1.17743418777255,1.32697839018452,1.32477286128242,1.71621392540386,1.88437973972575,1.79175698452409,1.6558936292372,1.13805635286484,1.29273805342393,1.33739733716298,1.39151695015662,1.17218389227462,1.20156638248932,1.18225653199861,1.15915130216831,1.2669923042121,1.11155828500359,1.24201675492173,1.24051558602965,4253,"MIA SH3 domain ER export factor 2","protein_coding",null,null,"GO:0005515,GO:0005783,GO:0005789,GO:0006888,GO:0009306,GO:0016020,GO:0035459,GO:0070971","protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|endoplasmic reticulum to Golgi vesicle-mediated transport|protein secretion|membrane|vesicle cargo loading|endoplasmic reticulum exit site","WP5323","Fatty Acids and Lipoproteins Transport in Hepatocytes","R-HSA-199977,R-HSA-199991,R-HSA-392499,R-HSA-446203,R-HSA-5653656,R-HSA-5694530,R-HSA-597592,R-HSA-948021","ER to Golgi Anterograde Transport|Membrane Trafficking|Metabolism of proteins|Asparagine N-linked glycosylation|Vesicle-mediated transport|Cargo concentration in the ER|Post-translational protein modification|Transport to the Golgi and subsequent modification"]
["MID1IP1-AS1",0.271111360124571,0.184194203017762,0.254529048658116,0.37144510468366,0.302764124372239,0.545544392608736,0.180674607631346,0.531701909023749,0.623317205218809,0.48492783689337,0.254964560505951,0.428623727568703,0.14732828549029,0.369244986157993,0.180094320242209,0.073444214790652,0.186183678821397,0.0716713694552448,0.107385814725961,0.335193985912678,0.109666681116056,0.368144771606112,0.497057965899749,0.189191697253409,0.383980139569107,0.110401952559394,0.562177465408271,0.254876047129657,100874211,"MID1IP1 antisense RNA 1","non_coding"]
["MILR1",2.04602730356968,2.04230704894084,2.05235098826468,1.6861999765172,1.71042070262239,1.72407772491275,2.25006368499505,2.15890046622531,1.06422643176752,0.921605111794154,1.23644409255626,1.08011155150252,1.00616927787654,1.23120025168109,1.26611764533916,1.79242036928043,1.43608065617668,1.37484923086615,1.6465205093105,1.54108619285605,1.40981028676294,1.47895388766438,1.78947488542636,1.74809852215444,1.66597513022399,1.72972617620328,1.60349562081472,1.75528735982428,284021,"mast cell immunoglobulin like receptor 1","protein_coding",null,null,"GO:0004888,GO:0005515,GO:0005886,GO:0007166,GO:0033004,GO:0043303","transmembrane signaling receptor activity|protein binding|plasma membrane|cell surface receptor signaling pathway|negative regulation of mast cell activation|mast cell degranulation"]
["MIR3142HG",0,0,0,0.0111529677678959,0.056817253710925,0,0.021699659518795,0.0228068857808782,0,0,0,0,0,0,0,0,0.0559032961430944,0.0107599812642041,0,0,0,0,0,0.0113612960559424,0,0.0110497208773854,0.0225065007721689,0,107075116,"MIR3142 host gene","non_coding",null,null,"GO:0016442,GO:0035195","RISC complex|miRNA-mediated post-transcriptional gene silencing"]
["MIR3936HG",0.149590539596243,0.0426856266260919,0.0140440952803273,0.0860796202640936,0.0438520735078549,0.0983311979574459,0.0697833112715967,0.132019215083429,0,0.115259890541376,0.112545003400756,0.0602002046993881,0.0569037107110112,0.0855697592783452,0.0556473460104673,0.0851007327873926,0.143822242463588,0.027682171554301,0.0414764301050329,0.0575397741263346,0,0.0284382642661325,0.162446674077029,0.0876875169511917,0.0444922603451884,0.0426413756833176,0.0868536106379926,0.0281264830826448,553103,"MIR3936 host gene","non_coding"]
["MIXL1",0,0.012890816018136,0.0127237102539717,0,0.105944610640059,0,0.0252889948539803,0,0.0545285036239682,0.052211745287974,0.0127454811543591,0.0272701781971587,0.0257768945955862,0.0129207898625421,0,0.0770998091919967,0,0.0125397871143414,0,0.0130325129431441,0,0,0.0668972317488931,0.0132405652376443,0.0134364091070939,0.0128774524855603,0,0,83881,"Mix paired-like homeobox","protein_coding",null,null,"GO:0000785,GO:0000978,GO:0000981,GO:0000987,GO:0001228,GO:0001706,GO:0002244,GO:0005654,GO:0006357,GO:0007369,GO:0007492,GO:0007507,GO:0035987,GO:0042074,GO:0042803,GO:0045944,GO:0048565,GO:0061629,GO:1901533,GO:1990837,GO:2000382","chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|endoderm formation|hematopoietic progenitor cell differentiation|nucleoplasm|regulation of transcription by RNA polymerase II|gastrulation|endoderm development|heart development|endodermal cell differentiation|cell migration involved in gastrulation|protein homodimerization activity|positive regulation of transcription by RNA polymerase II|digestive tract development|RNA polymerase II-specific DNA-binding transcription factor binding|negative regulation of hematopoietic progenitor cell differentiation|sequence-specific double-stranded DNA binding|positive regulation of mesoderm development","WP2853,WP2406,WP2857,WP236","Endoderm differentiation|Cardiac progenitor differentiation|Mesodermal commitment pathway|Adipogenesis","R-HSA-1266738,R-HSA-9754189,R-HSA-9758941,R-HSA-9823730","Developmental Biology|Germ layer formation at gastrulation|Gastrulation|Formation of definitive endoderm","Homeobox"]
["MKRN2OS",0,0,0,0.0297269980291101,0.0403840227219392,0.0388091373201155,0,0.0202630744500098,0.0103926019267988,0,0,0,0,0,0,0,0,0,0.0381962575951293,0,0,0,0.0203999377460403,0,0.0204867901218933,0,0.0399923869604351,0,100129480,"MKRN2 opposite strand","protein_coding"]
["MLST8",12.9993548485428,15.8145749368117,16.4704177787218,17.7201454046305,12.8213588960151,16.6189703976447,17.1022384884341,15.3411114495583,11.6472317445379,17.8109752242595,15.9644172599381,12.9559738255559,10.5719797396675,12.6408497874167,13.5306890349921,12.9023931291286,11.9441818027567,14.1601223876646,15.5015722868593,12.6877280447332,13.2115008376416,15.4493139180861,13.6663432436016,13.5086288907518,12.1799147558732,15.667107189452,14.0790086303835,15.5316776400345,64223,"MTOR associated protein%2C LST8 homolog","protein_coding","hsa04151,hsa04150,hsa04140,hsa04136,hsa04714","PI3K-Akt signaling pathway|mTOR signaling pathway|Autophagy - animal|Autophagy - other|Thermogenesis","GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0006974,GO:0007010,GO:0010507,GO:0030307,GO:0030838,GO:0031669,GO:0031929,GO:0031931,GO:0031932,GO:0032008,GO:0032956,GO:0038202,GO:0043066,GO:0043539,GO:0045821,GO:0046889,GO:0050731,GO:0071456,GO:0071470,GO:1905857","protein binding|nucleoplasm|cytoplasm|cytosol|DNA damage response|cytoskeleton organization|negative regulation of autophagy|positive regulation of cell growth|positive regulation of actin filament polymerization|cellular response to nutrient levels|TOR signaling|TORC1 complex|TORC2 complex|positive regulation of TOR signaling|regulation of actin cytoskeleton organization|TORC1 signaling|negative regulation of apoptotic process|protein serine/threonine kinase activator activity|positive regulation of glycolytic process|positive regulation of lipid biosynthetic process|positive regulation of peptidyl-tyrosine phosphorylation|cellular response to hypoxia|cellular response to osmotic stress|positive regulation of pentose-phosphate shunt","WP5115,WP4963,WP3850,WP4321,WP4549,WP5200,WP4746,WP4018,WP3844,WP5358,WP5180,WP3932,WP4538,WP5381,WP4577,WP4674,WP4923,WP5087,WP585,WP4172,WP3888,WP5098,WP3915,WP1471","Network map of SARS-CoV-2 signaling pathway|p53 transcriptional gene network|Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling|Thermogenesis|Fragile X syndrome|Dravet syndrome|Thyroid hormones production and peripheral downstream signaling effects|Clear cell renal cell carcinoma pathways|PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer|JAK-STAT signaling in the regulation of Beta-cells|DYRK1A involvement regarding cell proliferation in brain development|Focal adhesion: PI3K-Akt-mTOR-signaling pathway|Regulatory circuits of the STAT3 signaling pathway|Smith-Magenis and Potocki-Lupski syndrome copy number variation|Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway|Head and neck squamous cell carcinoma|Autophagy|Pleural mesothelioma|Interferon type I signaling pathways|PI3K-Akt signaling pathway|VEGFA-VEGFR2 signaling|T-cell activation SARS-CoV-2|Angiopoietin-like protein 8 regulatory pathway|Target of rapamycin signaling","R-HSA-1257604,R-HSA-1280218,R-HSA-162582,R-HSA-1632852,R-HSA-1643685,R-HSA-165159,R-HSA-166208,R-HSA-168256,R-HSA-194138,R-HSA-212436,R-HSA-2219528,R-HSA-2262752,R-HSA-3371556,R-HSA-3371571,R-HSA-3700989,R-HSA-380972,R-HSA-388841,R-HSA-389356,R-HSA-389357,R-HSA-4420097,R-HSA-5218920,R-HSA-5628897,R-HSA-5633007,R-HSA-5663202,R-HSA-5674400,R-HSA-6804757,R-HSA-6806003,R-HSA-6807070,R-HSA-73857,R-HSA-74160,R-HSA-8943724,R-HSA-8953897,R-HSA-9006925,R-HSA-9006934,R-HSA-9612973,R-HSA-9639288,R-HSA-9711097","PIP3 activates AKT signaling|Adaptive Immune System|Signal Transduction|Macroautophagy|Disease|MTOR signalling|mTORC1-mediated signalling|Immune System|Signaling by VEGF|Generic Transcription Pathway|PI3K/AKT Signaling in Cancer|Cellular responses to stress|Cellular response to heat stress|HSF1-dependent transactivation|Transcriptional Regulation by TP53|Energy dependent regulation of mTOR by LKB1-AMPK|Costimulation by the CD28 family|CD28 co-stimulation|CD28 dependent PI3K/Akt signaling|VEGFA-VEGFR2 Pathway|VEGFR2 mediated vascular permeability|TP53 Regulates Metabolic Genes|Regulation of TP53 Activity|Diseases of signal transduction by growth factor receptors and second messengers|Constitutive Signaling by AKT1 E17K in Cancer|Regulation of TP53 Degradation|Regulation of TP53 Expression and Degradation|PTEN Regulation|RNA Polymerase II Transcription|Gene expression (Transcription)|Regulation of PTEN gene transcription|Cellular responses to stimuli|Intracellular signaling by second messengers|Signaling by Receptor Tyrosine Kinases|Autophagy|Amino acids regulate mTORC1|Cellular response to starvation"]
["MMP2",534.088528232344,641.183664106649,581.583346049273,641.825792559256,598.485267615401,697.465303642746,601.220924929884,664.328119626967,548.95363606564,727.964869264842,645.840841836709,570.563809495821,569.124741603787,658.546079383199,571.178227123378,629.977033778576,429.313320329319,464.145888852076,358.979633580963,440.70001053511,428.219707703138,443.679340358295,281.011952113461,354.175284258523,430.641518651197,436.482355779708,281.476312538162,422.817782416031,4313,"matrix metallopeptidase 2","protein_coding","hsa04670,hsa04912,hsa04915,hsa04926,hsa05200,hsa05205,hsa05219,hsa05418,hsa05415,hsa04933,hsa01522","Leukocyte transendothelial migration|GnRH signaling pathway|Estrogen signaling pathway|Relaxin signaling pathway|Pathways in cancer|Proteoglycans in cancer|Bladder cancer|Fluid shear stress and atherosclerosis|Diabetic cardiomyopathy|AGE-RAGE signaling pathway in diabetic complications|Endocrine resistance","GO:0001525,GO:0001541,GO:0001542,GO:0001553,GO:0001666,GO:0001955,GO:0001957,GO:0001968,GO:0004175,GO:0004222,GO:0004252,GO:0005515,GO:0005576,GO:0005615,GO:0005634,GO:0005739,GO:0005886,GO:0006508,GO:0007162,GO:0007507,GO:0007566,GO:0007567,GO:0008237,GO:0008270,GO:0009410,GO:0009612,GO:0014012,GO:0014823,GO:0019538,GO:0022617,GO:0030017,GO:0030163,GO:0030198,GO:0030335,GO:0030574,GO:0032526,GO:0034614,GO:0035094,GO:0035987,GO:0042542,GO:0043065,GO:0043627,GO:0045906,GO:0048013,GO:0048246,GO:0048771,GO:0051602,GO:0055093,GO:0060325,GO:0060346,GO:0060740,GO:0062023,GO:0071230,GO:0071347,GO:0071392,GO:0071492,GO:0071498,GO:1904645,GO:1904707","angiogenesis|ovarian follicle development|ovulation from ovarian follicle|luteinization|response to hypoxia|blood vessel maturation|intramembranous ossification|fibronectin binding|endopeptidase activity|metalloendopeptidase activity|serine-type endopeptidase activity|protein binding|extracellular region|extracellular space|nucleus|mitochondrion|plasma membrane|proteolysis|negative regulation of cell adhesion|heart development|embryo implantation|parturition|metallopeptidase activity|zinc ion binding|response to xenobiotic stimulus|response to mechanical stimulus|peripheral nervous system axon regeneration|response to activity|protein metabolic process|extracellular matrix disassembly|sarcomere|protein catabolic process|extracellular matrix organization|positive regulation of cell migration|collagen catabolic process|response to retinoic acid|cellular response to reactive oxygen species|response to nicotine|endodermal cell differentiation|response to hydrogen peroxide|positive regulation of apoptotic process|response to estrogen|negative regulation of vasoconstriction|ephrin receptor signaling pathway|macrophage chemotaxis|tissue remodeling|response to electrical stimulus|response to hyperoxia|face morphogenesis|bone trabecula formation|prostate gland epithelium morphogenesis|collagen-containing extracellular matrix|cellular response to amino acid stimulus|cellular response to interleukin-1|cellular response to estradiol stimulus|cellular response to UV-A|cellular response to fluid shear stress|response to amyloid-beta|positive regulation of vascular associated smooth muscle cell proliferation","WP5316,WP5413,WP2828,WP5283,WP5097,WP4239,WP129,WP4564,WP5055,WP4754,WP3624,WP5158,WP5356,WP3303,WP5144,WP3611,WP4565,WP4673,WP2324,WP5087,WP3617,WP3888","Primary ovarian insufficiency|IL-24 Signaling pathway|Bladder cancer|Chronic hyperglycemia impairment of neuron function|CCL18 signaling pathway|Epithelial to mesenchymal transition in colorectal cancer|Matrix metalloproteinases|Neural crest cell migration during development|Burn wound healing|IL-18 signaling pathway|Lung fibrosis|Urotensin-II-mediated signaling pathway|Disturbed pathways in Duchenne Muscular Dystrophy|RAC1/PAK1/p38/MMP2 pathway|NRP1-triggered signaling pathways in pancreatic cancer |Photodynamic therapy-induced AP-1 survival signaling|Neural crest cell migration in cancer|Male infertility|AGE/RAGE pathway|Pleural mesothelioma|Photodynamic therapy-induced NF-kB survival signaling|VEGFA-VEGFR2 signaling","R-HSA-1266738,R-HSA-1280215,R-HSA-1442490,R-HSA-1442490,R-HSA-1474228,R-HSA-1474228,R-HSA-1474244,R-HSA-1474244,R-HSA-1592389,R-HSA-162582,R-HSA-168256,R-HSA-2682334,R-HSA-381426,R-HSA-392499,R-HSA-3928665,R-HSA-422475,R-HSA-449147,R-HSA-6785807,R-HSA-8939211,R-HSA-9006931,R-HSA-9009391,R-HSA-9675108","Developmental Biology|Cytokine Signaling in Immune system|Collagen degradation|Collagen degradation|Degradation of the extracellular matrix|Degradation of the extracellular matrix|Extracellular matrix organization|Extracellular matrix organization|Activation of Matrix Metalloproteinases|Signal Transduction|Immune System|EPH-Ephrin signaling|Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)|Metabolism of proteins|EPH-ephrin mediated repulsion of cells|Axon guidance|Signaling by Interleukins|Interleukin-4 and Interleukin-13 signaling|ESR-mediated signaling|Signaling by Nuclear Receptors|Extra-nuclear estrogen signaling|Nervous system development"]
["MOB3C",3.64248065226311,4.27772464704416,4.64973320148737,4.20627970457906,4.10406633120095,4.55481614081271,4.20465498462856,4.06383955757906,4.26202002162023,4.6716013649777,4.75381404230095,5.00148322514125,4.14438885409192,4.86349487042102,4.60594483223797,4.72230351481238,4.45793425642101,5.32191418031478,4.35406724278749,4.76258158359394,5.34111893882293,5.34361945632202,4.42152652762497,4.62073818929898,5.13127709986332,5.07673921800179,4.6846959392505,5.13652989292942,148932,"MOB kinase activator 3C","protein_coding",null,null,"GO:0001934,GO:0005515,GO:0005634,GO:0005737,GO:0007165,GO:0030295,GO:0046872","positive regulation of protein phosphorylation|protein binding|nucleus|cytoplasm|signal transduction|protein kinase activator activity|metal ion binding"]
["MORF4L2-AS1",0.0844140351834335,0.0802917527977219,0.15850183525146,0.197897266628956,0.0824858418174891,0.0440383782481652,0.122511717241464,0.101170837446213,0.0566060509958626,0.0632345276308683,0.0970279687460765,0.0471819627993638,0.0445983327684595,0.107304597230047,0.0785045805147667,0.0978234009111398,0.0991943107207114,0.0781053337278451,0.199377420799489,0.135290544070531,0.11508514622339,0.249631360788445,0.240746238181089,0.0824702012244507,0.0929889273278005,0.258449664864163,0.254133946784421,0.0793589600964396,340544,"MORF4L2 antisense RNA 1","non_coding"]
["MPPED2",0.321013479480235,0.449524033140537,0.496717149160511,0.324974532870441,0.438572312479668,0.513578101922632,0.471439399601741,0.460518528830739,1.36333885574157,0.936119632002816,1.19919251349352,1.15729566523406,1.0232565935012,1.14767644391019,1.30473360527971,1.33020762428639,0.808738049401105,0.695802630093458,0.848855914221496,0.948946284814133,0.838830999631555,0.912580106023012,1.03876375030954,0.935056338181852,0.842800205778677,0.844455027581878,0.782349691854086,0.734914082116306,744,"metallophosphoesterase domain containing 2","protein_coding",null,null,"GO:0005515,GO:0008081,GO:0016208,GO:0019002,GO:0030145","protein binding|phosphoric diester hydrolase activity|AMP binding|GMP binding|manganese ion binding"]
["MPZL3",0,0.0108184949620559,0.00533912651796411,0.0218165226042048,0,0.00534035017237244,0,0.00557662038397422,0.022881264495374,0.0164318293319272,0.00534826202869627,0.0514940358552044,0.043266028143984,0.0216873004528239,0.010577691720555,0.00539210690868078,0.0109353451864719,0.0210477945741984,0.0157680436812804,0.010937412761145,0.0268382595136339,0.0162170101922692,0.00561428666449571,0.0111120186741243,0.00563818939114132,0.0108072797442107,0,0.0160392159857361,196264,"myelin protein zero like 3","protein_coding",null,null,"GO:0005515,GO:0005886,GO:0007155,GO:0030198,GO:0042633","protein binding|plasma membrane|cell adhesion|extracellular matrix organization|hair cycle"]
["MRPL1",17.4125679689783,15.0565828182553,17.8767587633824,18.7238680615926,14.5264938515824,16.4374614811962,18.3219736231784,18.1995260609452,14.5148031579527,8.86032206648721,17.0011918881906,15.8797380811465,16.7555518694795,13.5386895248111,16.7269765379821,13.7472568716568,21.2407214234356,19.2103668904126,32.8222229424876,20.7152736008808,23.88362981351,23.9219532645554,37.867909630974,27.4337299841648,24.22310116206,22.9320358718774,36.9408487090948,24.9537439786253,65008,"mitochondrial ribosomal protein L1","protein_coding","hsa03010","Ribosome","GO:0003723,GO:0003735,GO:0005515,GO:0005743,GO:0005762,GO:0032543","RNA binding|structural constituent of ribosome|protein binding|mitochondrial inner membrane|mitochondrial large ribosomal subunit|mitochondrial translation",null,null,"R-HSA-392499,R-HSA-392499,R-HSA-5368286,R-HSA-5368287,R-HSA-5368287,R-HSA-5389840,R-HSA-5389840,R-HSA-5419276,R-HSA-72766,R-HSA-72766","Metabolism of proteins|Metabolism of proteins|Mitochondrial translation initiation|Mitochondrial translation|Mitochondrial translation|Mitochondrial translation elongation|Mitochondrial translation elongation|Mitochondrial translation termination|Translation|Translation"]
["MRPL33",81.0278359531815,57.6391522728402,81.5019764985535,69.4151932009459,68.9104258903375,60.0940774396785,84.4106076314828,77.6344596163315,85.1324921084528,45.4851149735356,78.0484090414485,79.5988318812162,77.1576792156493,74.1641638182091,77.6254734471388,66.2611392637647,127.083994718541,103.841656193797,129.128482756382,97.2062559146766,113.390167170957,103.449840332409,138.559047635397,137.328145272795,125.78645148464,114.654600999713,159.591115943868,116.782541936458,9553,"mitochondrial ribosomal protein L33","protein_coding","hsa03010","Ribosome","GO:0003735,GO:0005739,GO:0005743,GO:0005762,GO:0032543","structural constituent of ribosome|mitochondrion|mitochondrial inner membrane|mitochondrial large ribosomal subunit|mitochondrial translation",null,null,"R-HSA-392499,R-HSA-392499,R-HSA-5368286,R-HSA-5368287,R-HSA-5368287,R-HSA-5389840,R-HSA-5389840,R-HSA-5419276,R-HSA-72766,R-HSA-72766","Metabolism of proteins|Metabolism of proteins|Mitochondrial translation initiation|Mitochondrial translation|Mitochondrial translation|Mitochondrial translation elongation|Mitochondrial translation elongation|Mitochondrial translation termination|Translation|Translation"]
["MRPL45",33.3611369492191,33.5810820632244,35.6064387855135,33.809780122235,31.9036964978389,32.615475140958,36.1297095350124,36.2541369740377,30.2744323711845,25.5443526376768,32.5985008023133,32.6385313932466,28.6723801352314,31.5078910326332,33.705307238036,33.9354834981435,37.2981176339232,28.9085291865842,43.0572171281904,32.0807767963955,34.9939105991138,31.4635059432832,40.9885584964491,37.8837552038925,34.4516970144544,36.7623573233318,41.1683318106936,37.7926479538212,84311,"mitochondrial ribosomal protein L45","protein_coding",null,null,"GO:0003723,GO:0005515,GO:0005739,GO:0005743,GO:0005762,GO:0032543","RNA binding|protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial large ribosomal subunit|mitochondrial translation","WP5287","17q12 copy number variation syndrome"]
["MRPS17",10.0067025201378,10.1496987533433,11.4776272973524,12.086732196974,9.48316230767494,12.2314351747537,12.4482174456543,11.6773681462541,10.9762809421803,8.99812862441853,12.2637504937522,13.0893648886439,10.894209043427,10.2452458779712,10.372948829861,10.045984264556,15.9476641282421,14.9566028930153,19.0129410914808,14.1074252704838,13.6473000437458,15.3651177531658,17.2842070526669,17.4881771162385,16.3701956210116,14.4845383671429,18.9138407286966,16.4878829681814,51373,"mitochondrial ribosomal protein S17","protein_coding","hsa03010","Ribosome","GO:0003735,GO:0005515,GO:0005743,GO:0005763,GO:0006412,GO:0019843,GO:0032543","structural constituent of ribosome|protein binding|mitochondrial inner membrane|mitochondrial small ribosomal subunit|translation|rRNA binding|mitochondrial translation",null,null,"R-HSA-392499,R-HSA-392499,R-HSA-5368286,R-HSA-5368287,R-HSA-5368287,R-HSA-5389840,R-HSA-5389840,R-HSA-5419276,R-HSA-72766,R-HSA-72766","Metabolism of proteins|Metabolism of proteins|Mitochondrial translation initiation|Mitochondrial translation|Mitochondrial translation|Mitochondrial translation elongation|Mitochondrial translation elongation|Mitochondrial translation termination|Translation|Translation"]
["MSANTD1",0.00591793967842878,0.0056289424939786,0,0.0283782429044816,0.0173482846237441,0,0.0110427685542408,5.80311319869107E-3,0.0029763225496178,0.0113994688669352,0.00556548013524047,0,0.00844186224214398,0.0169260928890865,0.00825547619463738,0.0112222115245431,0.0113794810502474,0.0328539669423822,0.00273474303144052,0.0113816325988644,0.0251354588551399,0.00843782967193813,0.00292115464211961,0.0144541626002604,0.0146679570329362,0.014057767834127,0.00572668153566274,0.00834532203868157,345222,"Myb/SANT DNA binding domain containing 1","protein_coding",null,null,"GO:0016604,GO:0045893","nuclear body|positive regulation of DNA-templated transcription"]
["MSTN",0,0.0363814587585279,0.0179549199681801,0.00917083337565902,0.0934390876920356,0.0718361399561415,0.00892156984117895,0,0,9.20975180718165E-3,0.0269784625924303,0.0481025048192166,0.0727495471452588,0.0091165133155716,0.0800362413619864,0.0634658060411594,0.0275808103142305,0.0353907578154312,0.00883771160568397,0.0183906833940502,0.018050847831802,0.00908934945150246,0.00944012727552666,0.028026411058185,0.0189606369024546,0.109031229487532,0.0370131740261707,0.0179793978414069,2660,"myostatin","protein_coding","hsa04060","Cytokine-cytokine receptor interaction","GO:0005102,GO:0005125,GO:0005515,GO:0005615,GO:0007179,GO:0007517,GO:0008083,GO:0008201,GO:0009629,GO:0010592,GO:0010759,GO:0014732,GO:0014741,GO:0014816,GO:0014839,GO:0014850,GO:0022602,GO:0033574,GO:0042802,GO:0042803,GO:0043627,GO:0045471,GO:0045662,GO:0045893,GO:0046627,GO:0046716,GO:0048632,GO:0051602,GO:0051898,GO:0071549,GO:1902723,GO:1902725,GO:2000818","signaling receptor binding|cytokine activity|protein binding|extracellular space|transforming growth factor beta receptor signaling pathway|muscle organ development|growth factor activity|heparin binding|response to gravity|positive regulation of lamellipodium assembly|positive regulation of macrophage chemotaxis|skeletal muscle atrophy|negative regulation of muscle hypertrophy|skeletal muscle satellite cell differentiation|myoblast migration involved in skeletal muscle regeneration|response to muscle activity|ovulation cycle process|response to testosterone|identical protein binding|protein homodimerization activity|response to estrogen|response to ethanol|negative regulation of myoblast differentiation|positive regulation of DNA-templated transcription|negative regulation of insulin receptor signaling pathway|muscle cell cellular homeostasis|negative regulation of skeletal muscle tissue growth|response to electrical stimulus|negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction|cellular response to dexamethasone stimulus|negative regulation of skeletal muscle satellite cell proliferation|negative regulation of satellite cell differentiation|negative regulation of myoblast proliferation","WP3850,WP5120,WP4879,WP516","Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling|Inclusion body myositis|Overlap between signal transduction pathways contributing to LMNA laminopathies|Hypertrophy model","R-HSA-212436,R-HSA-73857,R-HSA-74160,R-HSA-9614085,R-HSA-9617828","Generic Transcription Pathway|RNA Polymerase II Transcription|Gene expression (Transcription)|FOXO-mediated transcription|FOXO-mediated transcription of cell cycle genes"]
["MT1E",111.83577232316,98.5380715592868,144.076114377079,133.941312252444,80.9281199146408,84.4227753683765,156.63064397599,138.721048428214,66.5499737531774,55.6831964492119,82.9506837548333,78.6340157714904,60.4796436307595,73.1710911551349,82.5332195062591,63.6566409868618,139.380795690157,147.54348818403,167.181000182592,125.890353951339,112.411582282006,139.139773587714,156.852181659991,137.18457349239,125.99448699755,141.250566778027,196.337088642908,129.019797393893,4493,"metallothionein 1E","protein_coding","hsa04978","Mineral absorption","GO:0005515,GO:0005634,GO:0005737,GO:0006882,GO:0008270,GO:0010273,GO:0045926,GO:0046872,GO:0071276,GO:0071280,GO:0071294","protein binding|nucleus|cytoplasm|intracellular zinc ion homeostasis|zinc ion binding|detoxification of copper ion|negative regulation of growth|metal ion binding|cellular response to cadmium ion|cellular response to copper ion|cellular response to zinc ion","WP3286,WP3529","Copper homeostasis|Zinc homeostasis","R-HSA-5660526,R-HSA-5661231,R-HSA-8953897","Response to metal ions|Metallothioneins bind metals|Cellular responses to stimuli"]
["MTFP1",1.83197579268642,2.08196349649309,2.01030129970299,2.16769199661815,1.13917339999899,1.78734402944715,1.53163589706757,1.67977846835191,1.24443382012793,1.60402499921549,2.05849082566096,1.31651418529487,0.85978342776858,0.861940987988227,0.862926783522422,1.39861639746081,3.04230375660002,3.74234617561543,3.34232424580433,3.15727291938226,3.25612281795598,4.04809781339593,3.24132144128855,3.41687218524109,3.58535100841085,3.54923276259786,3.43042376420708,3.78004541263129,51537,"mitochondrial fission process 1","protein_coding",null,null,"GO:0000266,GO:0005515,GO:0005739,GO:0005743,GO:0006915","mitochondrial fission|protein binding|mitochondrion|mitochondrial inner membrane|apoptotic process"]
["MTMR6",11.8656026430528,8.94693196509303,5.83176036993201,6.27834459334156,11.1733972422813,7.62826226992225,6.41994386827664,6.71271516874549,10.5274476962689,5.95335438861522,5.71775087607381,7.37693716062632,11.1972822667552,6.6520776197059,8.39410276379488,8.28394374818173,8.91681129423545,7.32390795455864,8.43572540059474,10.3472121921717,10.514963512336,9.63990824070182,13.8765395946341,10.7799122920804,10.3511684486731,7.86802899526746,10.7509989389243,6.79790006643008,9107,"myotubularin related protein 6","protein_coding","hsa00562,hsa04070","Inositol phosphate metabolism|Phosphatidylinositol signaling system","GO:0004438,GO:0004722,GO:0004725,GO:0005515,GO:0005635,GO:0005737,GO:0005783,GO:0005793,GO:0005829,GO:0006470,GO:0006661,GO:0006897,GO:0032587,GO:0046856,GO:0048471,GO:0052629,GO:0106018","phosphatidylinositol-3-phosphate phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein binding|nuclear envelope|cytoplasm|endoplasmic reticulum|endoplasmic reticulum-Golgi intermediate compartment|cytosol|protein dephosphorylation|phosphatidylinositol biosynthetic process|endocytosis|ruffle membrane|phosphatidylinositol dephosphorylation|perinuclear region of cytoplasm|phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity|phosphatidylinositol-3,5-bisphosphate phosphatase activity","WP5323,WP5346,WP4971","Fatty Acids and Lipoproteins Transport in Hepatocytes|8p23.1 copy number variation syndrome|Phosphoinositides metabolism","R-HSA-1430728,R-HSA-1483255,R-HSA-1483257,R-HSA-1660499,R-HSA-556833","Metabolism|PI Metabolism|Phospholipid metabolism|Synthesis of PIPs at the plasma membrane|Metabolism of lipids"]
["MUC17",0,0,0,0,0,0,0,0,0.00188923484023259,0,0,0,0,0,0,0.00178083798405427,0,0,0,0,0,0,0,0,0,0,0,0,140453,"mucin 17%2C cell surface associated","protein_coding",null,null,"GO:0005515,GO:0005576,GO:0005796,GO:0005886,GO:0009897,GO:0016324,GO:0019725,GO:0030165,GO:0030197,GO:0062023","protein binding|extracellular region|Golgi lumen|plasma membrane|external side of plasma membrane|apical plasma membrane|cellular homeostasis|PDZ domain binding|extracellular matrix constituent, lubricant activity|collagen-containing extracellular matrix",null,null,"R-HSA-1643685,R-HSA-168249,R-HSA-168256,R-HSA-3781865,R-HSA-3906995,R-HSA-392499,R-HSA-5083625,R-HSA-5083632,R-HSA-5083636,R-HSA-5173105,R-HSA-5621480,R-HSA-5621481,R-HSA-5668914,R-HSA-597592,R-HSA-913709,R-HSA-977068","Disease|Innate Immune System|Immune System|Diseases of glycosylation|Diseases associated with O-glycosylation of proteins|Metabolism of proteins|Defective GALNT3 causes HFTC|Defective C1GALT1C1 causes TNPS|Defective GALNT12 causes CRCS1|O-linked glycosylation|Dectin-2 family|C-type lectin receptors (CLRs)|Diseases of metabolism|Post-translational protein modification|O-linked glycosylation of mucins|Termination of O-glycan biosynthesis"]
["MVB12B",0.961947769251237,1.42271691286289,1.19566807968641,1.1278668486245,1.19946088717675,1.29517985995939,0.877263486897101,1.06551120110928,1.30556382655224,1.71985819631979,1.66405786052083,1.38218108705837,1.07714926219137,1.48285935816307,1.39860944960113,1.1561483751725,0.721647040758644,0.995358837802453,0.879035149252565,0.977143706420151,0.792845567537872,0.94269930176774,0.625969259830324,0.683007130928834,0.870416740987052,0.77241414335885,0.728954519681782,0.952743617841896,89853,"multivesicular body subunit 12B","protein_coding","hsa04144","Endocytosis","GO:0000813,GO:0005515,GO:0005634,GO:0005769,GO:0005770,GO:0005829,GO:0005886,GO:0008289,GO:0010008,GO:0015031,GO:0019075,GO:0031902,GO:0031982,GO:0042058,GO:0043130,GO:0043162,GO:0046755,GO:0070062","ESCRT I complex|protein binding|nucleus|early endosome|late endosome|cytosol|plasma membrane|lipid binding|endosome membrane|protein transport|virus maturation|late endosome membrane|vesicle|regulation of epidermal growth factor receptor signaling pathway|ubiquitin binding|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|viral budding|extracellular exosome",null,null,"R-HSA-162587,R-HSA-162588,R-HSA-162599,R-HSA-162906,R-HSA-1643685,R-HSA-174490,R-HSA-174495,R-HSA-175474,R-HSA-199991,R-HSA-5653656,R-HSA-5663205,R-HSA-917729,R-HSA-9609646,R-HSA-9610379,R-HSA-9612973,R-HSA-9615710,R-HSA-9824446","HIV Life Cycle|Budding and maturation of HIV virion|Late Phase of HIV Life Cycle|HIV Infection|Disease|Membrane binding and targetting of GAG proteins|Synthesis And Processing Of GAG, GAGPOL Polyproteins|Assembly Of The HIV Virion|Membrane Trafficking|Vesicle-mediated transport|Infectious disease|Endosomal Sorting Complex Required For Transport (ESCRT)|HCMV Infection|HCMV Late Events|Autophagy|Late endosomal microautophagy|Viral Infection Pathways"]
["MYADML2",0,0,0.0103211499572389,0.010543466266714,0.0107424465009726,0.0103235154229385,0,0,0.011058033616239,0.0105882097652712,0,0.110604372826567,0,0,0.010223951622233,0,0,0,0,0,0,0,0,0,0,0,0,0,255275,"myeloid associated differentiation marker like 2","protein_coding",null,null,"GO:0005515,GO:0005737,GO:0016020","protein binding|cytoplasm|membrane"]
["MYL12-AS1",12.893854821043,4.56074758467658,4.50162586505655,9.00396259138114,9.37075330231927,6.56479907063882,5.11268629595,10.0359161098499,9.66630818362308,6.53908209721823,3.71356454046337,11.6547911246769,7.18473141124175,6.74178424054209,3.6910452073318,6.41829981094272,8.89072986113588,1.92002135033915,6.64732639675863,6.08326145634448,4.63976942049155,5.22798593148985,15.4737796848984,13.6598102203484,13.0429271803052,10.5669025803933,12.8475617834588,7.06468725637796,104968399,"MYL12A and MYL12B antisense RNA 1","non_coding"]
["MYO1F",0.231802710780547,0.336526435275901,0.223351647004038,0.263264554847075,0.256311516016417,0.263500781078091,0.244726393174516,0.388811210749594,0.134988586873591,0.176254516934454,0.166366168469018,0.196389715081778,0.191436753855,0.215179834431786,0.119133676608288,0.231351769605312,0.310837001328976,0.530553029558716,0.417198385882623,0.363689393781999,0.368484019282915,0.243530390667343,0.283039326344502,0.184747683183505,0.362865142077527,0.394139217826884,0.271534641812042,0.344086371452315,4542,"myosin IF","protein_coding","hsa04814,hsa05130","Motor proteins|Pathogenic Escherichia coli infection","GO:0000146,GO:0003779,GO:0005515,GO:0005516,GO:0005524,GO:0005737,GO:0005829,GO:0005886,GO:0005902,GO:0007015,GO:0008150,GO:0015629,GO:0016461,GO:0030050,GO:0031982,GO:0051015","microfilament motor activity|actin binding|protein binding|calmodulin binding|ATP binding|cytoplasm|cytosol|plasma membrane|microvillus|actin filament organization|biological_process|actin cytoskeleton|unconventional myosin complex|vesicle transport along actin filament|vesicle|actin filament binding"]
["MYO9A",4.16442997049846,4.01508710948987,3.19937785294994,2.66132353549736,4.78881758070959,3.31630561678651,3.11511357207002,3.08509768542995,3.57062399332394,2.71950546763996,2.56006641775147,3.65303213699774,4.00663313414252,3.00913129753509,4.06531520874233,4.04467664453683,3.63330114796309,3.16063781959485,2.68088779392618,3.51890206276021,3.39644041038249,2.77457436325888,3.5264682661358,3.56120590044708,3.78482077942407,2.69065401304207,3.35852914814875,2.62210826465585,4649,"myosin IXA","protein_coding","hsa04814","Motor proteins","GO:0000146,GO:0005096,GO:0005515,GO:0005524,GO:0005829,GO:0005884,GO:0007601,GO:0016020,GO:0016461,GO:0034329,GO:0035556,GO:0044295,GO:0045198,GO:0045202,GO:0046872,GO:0051015,GO:0051056,GO:0150011","microfilament motor activity|GTPase activator activity|protein binding|ATP binding|cytosol|actin filament|visual perception|membrane|unconventional myosin complex|cell junction assembly|intracellular signal transduction|axonal growth cone|establishment of epithelial cell apical/basal polarity|synapse|metal ion binding|actin filament binding|regulation of small GTPase mediated signal transduction|regulation of neuron projection arborization",null,null,"R-HSA-162582,R-HSA-194315,R-HSA-8980692,R-HSA-9012999,R-HSA-9013026,R-HSA-9013424,R-HSA-9716542","Signal Transduction|Signaling by Rho GTPases|RHOA GTPase cycle|RHO GTPase cycle|RHOB GTPase cycle|RHOV GTPase cycle|Signaling by Rho GTPases, Miro GTPases and RHOBTB3"]
["MYT1L",0,1.7148095947079E-3,0,0,0,0.00846484076278938,0,0,0.00181342284824894,0,1.69547632530901E-3,0,0.00514348348220517,0,0.00167664054158075,0.00512812735697169,1.73333119930033E-3,1.66811373531468E-3,0,1.73365892482034E-3,0.00170162319548722,0,0,0,0.00178738748756085,0,3.48916992976776E-3,0,23040,"myelin transcription factor 1 like","protein_coding",null,null,"GO:0000122,GO:0000785,GO:0000981,GO:0001227,GO:0003677,GO:0005634,GO:0006357,GO:0007399,GO:0008270,GO:0030182,GO:0048663,GO:0048665,GO:0048666","negative regulation of transcription by RNA polymerase II|chromatin|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA binding|nucleus|regulation of transcription by RNA polymerase II|nervous system development|zinc ion binding|neuron differentiation|neuron fate commitment|neuron fate specification|neuron development"]
["NAA60",8.29611372993327,9.8110411435346,10.0998720427219,10.3646413758414,9.09287762018764,9.87872118278605,8.98046849723546,8.93175966156529,9.14540111328346,13.506713606897,11.9306782577678,10.5261020020608,8.24850033814407,11.0542844184811,8.68452640238668,9.25088573587752,8.77304295836703,10.4929503014696,8.56235971979961,9.01142926470305,9.14696903876726,9.6407533833421,7.96326318730125,8.44178536478884,9.1686742659632,9.46559791002991,7.392744907669,11.0162315603218,79903,"N-alpha-acetyltransferase 60%2C NatF catalytic subunit","protein_coding",null,null,"GO:0000139,GO:0004402,GO:0004596,GO:0005515,GO:0006334,GO:0006474,GO:0007059,GO:0008283,GO:0010485,GO:0017196,GO:0042803","Golgi membrane|histone acetyltransferase activity|peptide alpha-N-acetyltransferase activity|protein binding|nucleosome assembly|N-terminal protein amino acid acetylation|chromosome segregation|cell population proliferation|histone H4 acetyltransferase activity|N-terminal peptidyl-methionine acetylation|protein homodimerization activity"]
["NALF1-IT1",0,0,0,0,0,0,0,0,0.0150051457814157,0.0143676205558633,0.0140291986806974,0,0.0141865642918154,0,0,0.0282884191999412,0,0,0.013787221370461,0.0143451401460507,0.0140800608848505,0.0141797875505176,0,0.0145741473479106,0.0147897164991753,0,0,0.0280486566214311,100874375,"NALF1 intronic transcript 1","non_coding"]
["NANP",2.99828531278144,3.29683890780317,3.42046654833211,3.06587253693879,3.38000359304438,3.23487885119223,3.43885111721993,3.69772602941365,2.34567556731238,2.06851800535547,2.59307031928265,2.49594196055115,2.59519375361413,2.92607475646758,2.73565308749722,3.11165544673389,2.71229915871458,2.5118713664141,2.67936502437998,3.23765248905049,2.54225995455995,2.91735612751488,3.3238407639001,2.62454602515347,2.74066708084771,2.2899042907928,3.1620302014381,2.29896834967782,140838,"N-acetylneuraminic acid phosphatase","protein_coding","hsa00520","Amino sugar and nucleotide sugar metabolism","GO:0005575,GO:0005829,GO:0005975,GO:0006045,GO:0016311,GO:0046380,GO:0050124","cellular_component|cytosol|carbohydrate metabolic process|N-acetylglucosamine biosynthetic process|dephosphorylation|N-acetylneuraminate biosynthetic process|N-acylneuraminate-9-phosphatase activity",null,null,"R-HSA-392499,R-HSA-4085001,R-HSA-446193,R-HSA-446203,R-HSA-446219,R-HSA-597592","Metabolism of proteins|Sialic acid metabolism|Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein|Asparagine N-linked glycosylation|Synthesis of substrates in N-glycan biosythesis|Post-translational protein modification"]
["NATD1",3.68454452819993,4.40416520013819,2.91515658220343,3.59660705540137,4.82365694074376,4.18379775925613,2.69299331613175,4.15983536020064,3.8051296920496,3.42232584138902,3.72215609401718,2.96996629430544,3.54555931506019,4.08606157223515,3.945172256562,3.90816759427068,2.43873056066913,2.8325525206729,2.06644193626385,2.59689801510715,2.62114710395739,2.52539399441081,1.83491875654051,1.99745915886641,2.42264914178917,2.18681393437054,1.86208316913814,2.63132917538452,256302,"N-acetyltransferase domain containing 1","protein_coding",null,null,"GO:0005515","protein binding"]
["NBR2",2.24026359678623,3.03416271984598,2.72049476397726,2.31201928573829,2.51031663554706,3.14414925460139,2.40821135548513,2.31618655839536,1.83701208855136,1.92313261810704,1.79768276265365,1.94765608063,1.48206665512183,1.91527074120975,1.81168053316824,1.80087603096428,2.09534845910434,1.85879405335147,1.19278769455323,1.73279444448926,1.63182436435743,2.08316065884434,1.64670527289531,1.62961216951283,1.78649621575133,1.31883958504555,1.40204114408234,1.72838127817385,10230,"neighbor of BRCA1 lncRNA 2","non_coding"]
["NCLN",30.6846700055525,30.0849997699438,29.7018800063457,35.5613468330556,27.1779342611416,27.6932565281045,26.7969508162862,28.6886204881606,27.5932194590171,39.5007781626489,34.5817460109843,29.3384470696122,23.2387950839228,27.3056667263836,22.8074579229868,22.56517617975,26.973158095686,33.0680013117131,31.3788354051959,29.3238872009274,26.5765281393336,31.6665327500044,19.604448271441,23.1723635941169,25.9624832411916,31.7938423031479,21.5839482969032,31.209176200767,56926,"nicalin","protein_coding",null,null,"GO:0005515,GO:0005789,GO:0009966,GO:0016020,GO:0032991,GO:0043022,GO:0043254,GO:0050821,GO:0061635,GO:0160063,GO:0160064","protein binding|endoplasmic reticulum membrane|regulation of signal transduction|membrane|protein-containing complex|ribosome binding|regulation of protein-containing complex assembly|protein stabilization|regulation of protein complex stability|multi-pass transmembrane protein insertion into ER membrane|multi-pass translocon complex"]
["NDC80",20.0459907276196,12.7716760162826,5.14243771792321,13.2302945734474,12.3772993140002,9.9062239735568,4.73187307286612,9.11360366626892,11.1977206109698,7.90103567867166,5.25855411527045,9.87348484290477,8.36819117717099,3.91656732636745,3.46675636737928,3.52242046891535,27.8306592445417,18.735556727643,15.7613685922338,19.0084105325783,27.6087675134807,20.8020151247101,21.7174657103228,27.462732172749,26.913576164485,20.9749169624506,23.3243887040395,21.0745943100633,10403,"NDC80 kinetochore complex component","protein_coding","hsa04110","Cell cycle","GO:0000070,GO:0000132,GO:0000278,GO:0000775,GO:0000776,GO:0000940,GO:0005515,GO:0005634,GO:0005654,GO:0005813,GO:0005829,GO:0007052,GO:0007057,GO:0007059,GO:0007094,GO:0008315,GO:0008608,GO:0014841,GO:0016020,GO:0030332,GO:0031262,GO:0031647,GO:0042802,GO:0051298,GO:0051301,GO:0051310,GO:0051315,GO:0051383,GO:0090267,GO:0140483","mitotic sister chromatid segregation|establishment of mitotic spindle orientation|mitotic cell cycle|chromosome, centromeric region|kinetochore|outer kinetochore|protein binding|nucleus|nucleoplasm|centrosome|cytosol|mitotic spindle organization|spindle assembly involved in female meiosis I|chromosome segregation|mitotic spindle assembly checkpoint signaling|G2/MI transition of meiotic cell cycle|attachment of spindle microtubules to kinetochore|skeletal muscle satellite cell proliferation|membrane|cyclin binding|Ndc80 complex|regulation of protein stability|identical protein binding|centrosome duplication|cell division|metaphase chromosome alignment|attachment of mitotic spindle microtubules to kinetochore|kinetochore organization|positive regulation of mitotic cell cycle spindle assembly checkpoint|kinetochore adaptor activity",null,null,"R-HSA-141424,R-HSA-141444,R-HSA-162582,R-HSA-1640170,R-HSA-194315,R-HSA-195258,R-HSA-2467813,R-HSA-2500257,R-HSA-2555396,R-HSA-5663220,R-HSA-68877,R-HSA-68882,R-HSA-68886,R-HSA-69278,R-HSA-69618,R-HSA-69620,R-HSA-9648025,R-HSA-9716542","Amplification of signal from the kinetochores|Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal|Signal Transduction|Cell Cycle|Signaling by Rho GTPases|RHO GTPase Effectors|Separation of Sister Chromatids|Resolution of Sister Chromatid Cohesion|Mitotic Metaphase and Anaphase|RHO GTPases Activate Formins|Mitotic Prometaphase|Mitotic Anaphase|M Phase|Cell Cycle, Mitotic|Mitotic Spindle Checkpoint|Cell Cycle Checkpoints|EML4 and NUDC in mitotic spindle formation|Signaling by Rho GTPases, Miro GTPases and RHOBTB3"]
["NDST1",34.4404055343607,36.0400137618627,28.0502311428707,28.5159112484695,35.4627781098605,34.0397379639103,27.1191441987481,28.8762863300486,34.2461645500527,41.5959393645718,28.75885276927,31.822963005812,31.5194621962507,31.022729922769,28.457674629696,32.3061532434711,28.5740889313701,29.9925305812163,22.0738786657933,30.8522144929387,29.8421575282861,28.6900080095357,22.7359740658308,26.9672536681424,30.5912282649406,25.8752492494391,20.4563591699267,24.9809031148518,3340,"N-deacetylase and N-sulfotransferase 1","protein_coding","hsa00534","Glycosaminoglycan biosynthesis - heparan sulfate / heparin","GO:0000139,GO:0003279,GO:0005515,GO:0005794,GO:0006954,GO:0007585,GO:0008283,GO:0008543,GO:0015014,GO:0015015,GO:0015016,GO:0019213,GO:0030210,GO:0030900,GO:0030901,GO:0032588,GO:0035904,GO:0043410,GO:0045880,GO:0048702,GO:0048703,GO:0050119,GO:0060976,GO:0102140","Golgi membrane|cardiac septum development|protein binding|Golgi apparatus|inflammatory response|respiratory gaseous exchange by respiratory system|cell population proliferation|fibroblast growth factor receptor signaling pathway|heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|heparan sulfate proteoglycan biosynthetic process, enzymatic modification|[heparan sulfate]-glucosamine N-sulfotransferase activity|deacetylase activity|heparin biosynthetic process|forebrain development|midbrain development|trans-Golgi network membrane|aorta development|positive regulation of MAPK cascade|positive regulation of smoothened signaling pathway|embryonic neurocranium morphogenesis|embryonic viscerocranium morphogenesis|N-acetylglucosamine deacetylase activity|coronary vasculature development|heparan sulfate N-deacetylase activity","WP702,WP5348,WP5395","Metapathway biotransformation Phase I and II|11p11.2 copy number variation syndrome |Glycosaminoglycan synthesis in fibroblasts","R-HSA-1430728,R-HSA-1630316,R-HSA-1638091,R-HSA-2022928,R-HSA-71387","Metabolism|Glycosaminoglycan metabolism|Heparan sulfate/heparin (HS-GAG) metabolism|HS-GAG biosynthesis|Metabolism of carbohydrates"]
["NDUFA9",7.89395149361415,6.88863394206113,8.377265858878,8.55152335405175,6.73642930100076,7.49158586974069,9.18591565662148,8.8448028977532,7.41457299015517,7.03740876378268,8.50081799531941,8.07179488318141,7.42117751706274,7.30447537241698,7.40733370435371,6.95550816934084,8.82708496764686,9.04716376794624,9.38877930740982,8.21762795334222,7.94702833286193,8.32835465508393,9.29626701138852,9.08315768676617,7.7175045169825,9.1160620396721,10.5794855869392,8.71926024595575,4704,"NADH:ubiquinone oxidoreductase subunit A9","protein_coding","hsa00190,hsa04723,hsa04714,hsa05208,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022,hsa05415,hsa04932","Oxidative phosphorylation|Retrograde endocannabinoid signaling|Thermogenesis|Chemical carcinogenesis - reactive oxygen species|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases|Diabetic cardiomyopathy|Non-alcoholic fatty liver disease","GO:0003954,GO:0005515,GO:0005634,GO:0005739,GO:0005743,GO:0005747,GO:0005759,GO:0006120,GO:0006814,GO:0007623,GO:0008137,GO:0009060,GO:0031966,GO:0032981,GO:0042776,GO:0044877,GO:1901006","NADH dehydrogenase activity|protein binding|nucleus|mitochondrion|mitochondrial inner membrane|mitochondrial respiratory chain complex I|mitochondrial matrix|mitochondrial electron transport, NADH to ubiquinone|sodium ion transport|circadian rhythm|NADH dehydrogenase (ubiquinone) activity|aerobic respiration|mitochondrial membrane|mitochondrial respiratory chain complex I assembly|proton motive force-driven mitochondrial ATP synthesis|protein-containing complex binding|ubiquinone-6 biosynthetic process","WP623,WP111,WP4352,WP4396","Oxidative phosphorylation|Electron transport chain: OXPHOS system in mitochondria|Ciliary landscape|Nonalcoholic fatty liver disease","R-HSA-1428517,R-HSA-1430728,R-HSA-163200,R-HSA-611105,R-HSA-6799198","The citric acid (TCA) cycle and respiratory electron transport|Metabolism|Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.|Respiratory electron transport|Complex I biogenesis"]
["NDUFV1-DT",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.0102598258208248,0,0,0,0,0,0,0,0.0105360974881857,0,0,100505621,"NDUFV1 divergent transcript","non_coding"]
["NECAB2",0.0387301943035102,0.0552582609053287,0.0181806463327226,0.120719659022189,0.0662296522064274,0.0272772196304368,0.0361349215262693,0.123430800309084,0.0486966566577194,0.0652787472741076,0.0182117543218537,0.0389657934153367,0,0.0369244986157993,0.0630330120847732,0.0275415805464945,0.00930918394106989,0.044794605909528,0.062641725256811,0.0558656643187796,0.00913889009300467,0,0,0.00945958486267047,0.0479975174461384,0.00920016271328285,0.00936962442347119,0.0455135798445816,54550,"N-terminal EF-hand calcium binding protein 2","protein_coding",null,null,"GO:0005509,GO:0005515,GO:0005737,GO:0005886,GO:0030424,GO:0030425,GO:0031687,GO:0031802,GO:0042984,GO:0060168,GO:0070374,GO:1900451,GO:1904021,GO:1905477","calcium ion binding|protein binding|cytoplasm|plasma membrane|axon|dendrite|A2A adenosine receptor binding|type 5 metabotropic glutamate receptor binding|regulation of amyloid precursor protein biosynthetic process|positive regulation of adenosine receptor signaling pathway|positive regulation of ERK1 and ERK2 cascade|positive regulation of glutamate receptor signaling pathway|negative regulation of G protein-coupled receptor internalization|positive regulation of protein localization to membrane"]
["NEK6",36.9788617052596,39.1710111783524,37.2987795238584,33.1283163646777,41.9503062018612,41.7470584723173,37.9330340240168,36.3323180602936,40.6289867705073,46.2442406537968,35.899401244163,38.5325147137895,43.5911767011265,41.7630452639453,41.5743749612986,45.7595905452833,37.5242333536972,36.6536041680365,33.6415974100961,37.2007833970261,38.5852035924592,36.7891764729519,35.6787540730939,35.8975627700249,38.4074974932437,36.2138163133526,34.3540486539226,38.3927878379283,10783,"NIMA related kinase 6","protein_coding",null,null,"GO:0000287,GO:0000922,GO:0001222,GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005813,GO:0005829,GO:0005874,GO:0006468,GO:0006915,GO:0007052,GO:0007059,GO:0007077,GO:0007346,GO:0016607,GO:0018105,GO:0019894,GO:0019901,GO:0030071,GO:0031625,GO:0032991,GO:0034451,GO:0043123,GO:0046777,GO:0051225,GO:0051301,GO:0106310,GO:0140297,GO:2000772","magnesium ion binding|spindle pole|transcription corepressor binding|protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|centrosome|cytosol|microtubule|protein phosphorylation|apoptotic process|mitotic spindle organization|chromosome segregation|mitotic nuclear membrane disassembly|regulation of mitotic cell cycle|nuclear speck|peptidyl-serine phosphorylation|kinesin binding|protein kinase binding|regulation of mitotic metaphase/anaphase transition|ubiquitin protein ligase binding|protein-containing complex|centriolar satellite|positive regulation of canonical NF-kappaB signal transduction|protein autophosphorylation|spindle assembly|cell division|protein serine kinase activity|DNA-binding transcription factor binding|regulation of cellular senescence",null,null,"R-HSA-1640170,R-HSA-2980766,R-HSA-2980767,R-HSA-3301854,R-HSA-68875,R-HSA-68877,R-HSA-68886,R-HSA-69278,R-HSA-9648025","Cell Cycle|Nuclear Envelope Breakdown|Activation of NIMA Kinases NEK9, NEK6, NEK7|Nuclear Pore Complex (NPC) Disassembly|Mitotic Prophase|Mitotic Prometaphase|M Phase|Cell Cycle, Mitotic|EML4 and NUDC in mitotic spindle formation"]
["NEURL1B",4.02644571741611,3.02794978879649,0.598527131424114,2.53819472996034,3.38528637087877,2.31588560330211,0.61045359259938,1.74795421868929,2.71691429702811,2.65803439344093,1.28587963547886,1.9157565375061,2.00230762113052,1.09563553509061,0.674803078006034,0.81523421241094,4.45992617234854,4.65302975695344,0.852804105121065,3.89208181972565,4.96423031021191,4.15818574393157,1.26702753223139,3.26991075737114,4.74039523789812,3.91352332968592,1.27847920249063,3.57240032663163,54492,"neuralized E3 ubiquitin protein ligase 1B","protein_coding",null,null,"GO:0005515,GO:0005769,GO:0005829,GO:0007219,GO:0015629,GO:0016567,GO:0046872,GO:0061630,GO:0070086","protein binding|early endosome|cytosol|Notch signaling pathway|actin cytoskeleton|protein ubiquitination|metal ion binding|ubiquitin protein ligase activity|ubiquitin-dependent endocytosis",null,null,"R-HSA-157118,R-HSA-162582,R-HSA-1643685,R-HSA-1980143,R-HSA-1980145,R-HSA-2122948,R-HSA-2644602,R-HSA-2644603,R-HSA-2644606,R-HSA-2691230,R-HSA-2691232,R-HSA-2894858,R-HSA-2894862,R-HSA-2979096,R-HSA-5663202,R-HSA-9012852,R-HSA-9013507","Signaling by NOTCH|Signal Transduction|Disease|Signaling by NOTCH1|Signaling by NOTCH2|Activated NOTCH1 Transmits Signal to the Nucleus|Signaling by NOTCH1 PEST Domain Mutants in Cancer|Signaling by NOTCH1 in Cancer|Constitutive Signaling by NOTCH1 PEST Domain Mutants|Signaling by NOTCH1 HD Domain Mutants in Cancer|Constitutive Signaling by NOTCH1 HD Domain Mutants|Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer|Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants|NOTCH2 Activation and Transmission of Signal to the Nucleus|Diseases of signal transduction by growth factor receptors and second messengers|Signaling by NOTCH3|NOTCH3 Activation and Transmission of Signal to the Nucleus"]
["NFIA-AS1",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.264506818815446,0,0,0,0,0,0,0,0,645030,"NFIA antisense RNA 1","non_coding"]
["NHLH1",0.0632527537784351,0.0200546210872683,0.0890759238390101,0.040442048159535,0.072109249801601,0.0197991864036334,0.019671416020558,0.0206751510520436,0.0954355439355353,0.152301273041328,0.109056856541346,0.0424250171561585,0.0200509359994607,0.15075939208015,0.127453532229292,0.0499776823370099,0.0202712304199754,0.0487712877794783,0.0097432573392347,0.0506876578879815,0.0995020337071764,0.0501033948059942,0.0208147976454514,0.123592417321898,0.0418068325600467,0.0400676620942971,0,0.109018996414584,4807,"nescient helix-loop-helix 1","protein_coding",null,null,"GO:0000785,GO:0000977,GO:0000978,GO:0000981,GO:0001228,GO:0005515,GO:0005634,GO:0006357,GO:0007417,GO:0030154,GO:0045944,GO:0046983,GO:1990837","chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|central nervous system development|cell differentiation|positive regulation of transcription by RNA polymerase II|protein dimerization activity|sequence-specific double-stranded DNA binding"]
["NHSL1",0.87534192373025,0.980127712293376,0.768619435352545,0.756717646467523,0.802629420675191,0.901783297795272,0.74873379878208,0.652034326312351,0.999861800295828,1.02622882878573,1.11114117512427,0.960727313603954,0.994056804681561,0.902682609210979,1.24053682350448,1.14582676500768,0.575755280337272,0.646440895801073,0.512331242157005,0.778194783665979,0.684887244580289,0.542303442004465,0.619155870970429,0.662801390053553,0.635163785357484,0.602333078508773,0.523371299528293,0.57059354377356,57224,"NHS like 1","protein_coding",null,null,"GO:0030154","cell differentiation","WP4746","Thyroid hormones production and peripheral downstream signaling effects"]
["NIPAL3",18.7898277906781,14.7529246200417,11.3232695988511,11.5802085480454,18.2211557346762,14.6735210084183,11.1259478046435,12.9266651065464,11.7249172471851,10.5328606062057,8.12426084779674,10.0521136054209,11.2242533507757,9.60327444181436,8.87785986157374,10.0694129582493,16.4904095511868,15.7032946334724,11.2663586537959,15.8530020992468,15.4574163919818,15.3827705504571,11.413649435526,15.1631564050428,17.2472725262249,13.923896483759,11.0627906838869,13.7189084265691,57185,"NIPA like domain containing 3","protein_coding",null,null,"GO:0005515,GO:0015095,GO:0015693,GO:0016020,GO:1903830","protein binding|magnesium ion transmembrane transporter activity|magnesium ion transport|membrane|magnesium ion transmembrane transport",null,null,"R-HSA-382551,R-HSA-5223345","Transport of small molecules|Miscellaneous transport and binding events"]
["NKX3-2",0.0477312354763047,0.0113500810358886,0.0560147403611108,0.080109807437751,0,0,0.0222664058276082,0.0234025503497457,0.0240055762966075,0,0.0112221168729616,0,0,0.0227529446981818,0.0110974454969966,0.0565705771295858,0.0803087103335857,0.044164031111864,0.0220571128963462,0.034424526220337,0.0112628021332116,0.0340277239094096,0.0117803093358608,0.0233160551196764,0.0354913913864672,0.0340149442148465,0.0230943199601096,0.0112182210081731,579,"NK3 homeobox 2","protein_coding",null,null,"GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001227,GO:0001501,GO:0005515,GO:0005634,GO:0006357,GO:0006366,GO:0007368,GO:0030154,GO:0031016,GO:0032331,GO:0042474,GO:0043066,GO:0048536,GO:0048645,GO:0048705,GO:0048706,GO:0060576,GO:1990837","negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|skeletal system development|protein binding|nucleus|regulation of transcription by RNA polymerase II|transcription by RNA polymerase II|determination of left/right symmetry|cell differentiation|pancreas development|negative regulation of chondrocyte differentiation|middle ear morphogenesis|negative regulation of apoptotic process|spleen development|animal organ formation|skeletal system morphogenesis|embryonic skeletal system development|intestinal epithelial cell development|sequence-specific double-stranded DNA binding","WP4808,WP474","Endochondral ossification with skeletal dysplasias|Endochondral ossification","R-HSA-212436,R-HSA-73857,R-HSA-74160,R-HSA-8878166,R-HSA-8939902","Generic Transcription Pathway|RNA Polymerase II Transcription|Gene expression (Transcription)|Transcriptional regulation by RUNX2|Regulation of RUNX2 expression and activity"]
["NLK",3.34299519649668,3.26626669747268,3.08870571082537,2.45003352625877,3.56292753447837,2.8900965932847,2.56025470989499,2.68345843752352,3.22535102211155,2.67946022396269,2.73041109452637,3.12690630174366,3.43147298015968,3.03536823266886,2.65777890196815,3.64403922407297,3.38900370156114,3.35267218241373,2.7814013159505,3.67393723142084,3.52734429677447,3.56673894020635,3.91392826969014,3.4881926561768,3.83289061702616,2.92434778275434,3.22028405494384,2.84348777888857,51701,"nemo like kinase","protein_coding","hsa04010,hsa04310,hsa04068,hsa04520","MAPK signaling pathway|Wnt signaling pathway|FoxO signaling pathway|Adherens junction","GO:0000165,GO:0000287,GO:0004672,GO:0004674,GO:0004707,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006355,GO:0006468,GO:0007179,GO:0007223,GO:0018107,GO:0030178,GO:0031625,GO:0035556,GO:0042169,GO:0042501,GO:0050821,GO:0071470,GO:0106310,GO:0140297,GO:1904262","MAPK cascade|magnesium ion binding|protein kinase activity|protein serine/threonine kinase activity|MAP kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|cytosol|regulation of DNA-templated transcription|protein phosphorylation|transforming growth factor beta receptor signaling pathway|Wnt signaling pathway, calcium modulating pathway|peptidyl-threonine phosphorylation|negative regulation of Wnt signaling pathway|ubiquitin protein ligase binding|intracellular signal transduction|SH2 domain binding|serine phosphorylation of STAT protein|protein stabilization|cellular response to osmotic stress|protein serine kinase activity|DNA-binding transcription factor binding|negative regulation of TORC1 signaling","WP428,WP2853,WP364,WP399,WP2857,WP4258,WP363,WP382,WP2858,WP4336","Wnt signaling|Endoderm differentiation|IL6 signaling pathway|Wnt signaling pathway and pluripotency|Mesodermal commitment pathway|lncRNA in canonical Wnt signaling and colorectal cancer|Wnt signaling pathway|MAPK signaling pathway|Ectoderm differentiation|ncRNAs involved in Wnt signaling in hepatocellular carcinoma","R-HSA-162582,R-HSA-195721,R-HSA-3858494,R-HSA-4086398","Signal Transduction|Signaling by WNT|Beta-catenin independent WNT signaling|Ca2+ pathway"]
["NME7",12.1046591511519,9.49300884357305,13.2554697180438,10.9943713539573,10.7902912559049,11.5732499027659,13.702597905293,11.3310713119863,11.1809640932065,7.39008128690386,10.9876264716175,10.9438819136835,10.4839288373213,10.1436012583304,12.091767566697,11.0082499984314,17.7473520629579,14.4871598286097,21.5623712547031,18.6664187082531,18.6671763725808,16.5539097654211,25.1111938851268,20.4493603984524,19.0270506550831,18.4965271279806,27.8039531016758,17.3881663519277,29922,"NME/NM23 family member 7","protein_coding","hsa00230,hsa00240,hsa00983","Purine metabolism|Pyrimidine metabolism|Drug metabolism - other enzymes","GO:0004550,GO:0005515,GO:0005524,GO:0005813,GO:0005829,GO:0005879,GO:0006183,GO:0006228,GO:0006241,GO:0016310,GO:0046872","nucleoside diphosphate kinase activity|protein binding|ATP binding|centrosome|cytosol|axonemal microtubule|GTP biosynthetic process|UTP biosynthetic process|CTP biosynthetic process|phosphorylation|metal ion binding","WP4022,WP4803","Pyrimidine metabolism|Ciliopathies","R-HSA-1640170,R-HSA-380270,R-HSA-380287,R-HSA-380320,R-HSA-453274,R-HSA-68877,R-HSA-68886,R-HSA-69275,R-HSA-69278","Cell Cycle|Recruitment of mitotic centrosome proteins and complexes|Centrosome maturation|Recruitment of NuMA to mitotic centrosomes|Mitotic G2-G2/M phases|Mitotic Prometaphase|M Phase|G2/M Transition|Cell Cycle, Mitotic"]
["NOL7",43.2738333163158,38.6854267124433,46.734729658505,43.6308152401708,36.6463220385819,37.2296098388117,45.8296685813444,42.4642066860232,38.2464039140904,32.9209507888392,38.1485061569869,39.2711471627141,34.6314335409221,38.6148480652095,40.2444229135728,33.3234044130887,42.6795158811027,42.1500911036828,49.5723654704978,40.0085714292774,37.9256154455867,41.9772842472578,48.629478174495,43.8476092240215,40.2165229654322,44.1868612124372,48.3780365325874,46.4098949774664,51406,"nucleolar protein 7","protein_coding",null,null,"GO:0003723,GO:0005515,GO:0005694,GO:0005730,GO:0005739,GO:0032040,GO:0042274","RNA binding|protein binding|chromosome|nucleolus|mitochondrion|small-subunit processome|ribosomal small subunit biogenesis"]
["NOS2",0,0,0.0361019396507131,0.0061465951702289,0.0187877880316582,0,0.0119590610472103,0,0.0128931518911165,0.0246907183494484,0.0120545706210272,0.025791908908297,0.0426642538581012,0.0183305642201115,0.0298016278860146,0.012153393603018,0.00616185641748421,0,0,0.00616302145599471,0,0.00609198195525094,0.0189812544862408,0,0,0,0,0.00602519288099454,4843,"nitric oxide synthase 2","protein_coding","hsa00220,hsa00330,hsa04371,hsa04066,hsa04020,hsa04146,hsa04926,hsa05200,hsa05222,hsa05133,hsa05152,hsa05146,hsa05145,hsa05140,hsa05142,hsa05010,hsa05014,hsa05022","Arginine biosynthesis|Arginine and proline metabolism|Apelin signaling pathway|HIF-1 signaling pathway|Calcium signaling pathway|Peroxisome|Relaxin signaling pathway|Pathways in cancer|Small cell lung cancer|Pertussis|Tuberculosis|Amoebiasis|Toxoplasmosis|Leishmaniasis|Chagas disease|Alzheimer disease|Amyotrophic lateral sclerosis|Pathways of neurodegeneration - multiple diseases","GO:0001666,GO:0001912,GO:0002227,GO:0004517,GO:0005515,GO:0005516,GO:0005634,GO:0005654,GO:0005737,GO:0005777,GO:0005782,GO:0005829,GO:0005886,GO:0006527,GO:0006801,GO:0006809,GO:0006954,GO:0007263,GO:0007623,GO:0009617,GO:0009725,GO:0010181,GO:0010629,GO:0018119,GO:0020037,GO:0030863,GO:0031284,GO:0032310,GO:0032496,GO:0032755,GO:0032757,GO:0034617,GO:0034618,GO:0042127,GO:0042177,GO:0042742,GO:0042803,GO:0043457,GO:0045454,GO:0045776,GO:0046872,GO:0048471,GO:0050660,GO:0050661,GO:0050796,GO:0050829,GO:0051712,GO:0071222,GO:0071346,GO:0071466,GO:1900015","response to hypoxia|positive regulation of leukocyte mediated cytotoxicity|innate immune response in mucosa|nitric-oxide synthase activity|protein binding|calmodulin binding|nucleus|nucleoplasm|cytoplasm|peroxisome|peroxisomal matrix|cytosol|plasma membrane|arginine catabolic process|superoxide metabolic process|nitric oxide biosynthetic process|inflammatory response|nitric oxide mediated signal transduction|circadian rhythm|response to bacterium|response to hormone|FMN binding|negative regulation of gene expression|peptidyl-cysteine S-nitrosylation|heme binding|cortical cytoskeleton|positive regulation of guanylate cyclase activity|prostaglandin secretion|response to lipopolysaccharide|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|tetrahydrobiopterin binding|arginine binding|regulation of cell population proliferation|negative regulation of protein catabolic process|defense response to bacterium|protein homodimerization activity|regulation of cellular respiration|cell redox homeostasis|negative regulation of blood pressure|metal ion binding|perinuclear region of cytoplasm|flavin adenine dinucleotide binding|NADP binding|regulation of insulin secretion|defense response to Gram-negative bacterium|positive regulation of killing of cells of another organism|cellular response to lipopolysaccharide|cellular response to type II interferon|cellular response to xenobiotic stimulus|regulation of cytokine production involved in inflammatory response","WP3614,WP5124,WP5413,WP5283,WP2059,WP4008,WP619,WP4754,WP3932,WP5294,WP3594,WP5356,WP4947,WP4658,WP3303,WP2037,WP2431,WP3646,WP5093,WP1995,WP4673,WP4595,WP2324,WP4136,WP4919","Photodynamic therapy-induced HIF-1 survival signaling|Alzheimer's disease|IL-24 Signaling pathway|Chronic hyperglycemia impairment of neuron function|Alzheimer's disease and miRNA effects|NO/cGMP/PKG mediated neuroprotection|Type II interferon signaling|IL-18 signaling pathway|Focal adhesion: PI3K-Akt-mTOR-signaling pathway|Sildenafil treatment|Circadian rhythm genes|Disturbed pathways in Duchenne Muscular Dystrophy|Nitric oxide metabolism in cystic fibrosis|Small cell lung cancer|RAC1/PAK1/p38/MMP2 pathway|Prolactin signaling pathway|Spinal cord injury|Hepatitis C and hepatocellular carcinoma|Opioid receptor pathways|Effects of nitric oxide|Male infertility|Urea cycle and associated pathways|AGE/RAGE pathway|Fibrin complement receptor 3 signaling pathway|Neuroinflammation","R-HSA-109582,R-HSA-1222556,R-HSA-1280215,R-HSA-1643685,R-HSA-168249,R-HSA-168256,R-HSA-392154,R-HSA-418346,R-HSA-449147,R-HSA-5663205,R-HSA-6785807,R-HSA-9033241,R-HSA-9033241,R-HSA-9609507,R-HSA-9609507,R-HSA-9635486,R-HSA-9636249,R-HSA-9637687,R-HSA-9637690,R-HSA-9824439","Hemostasis|ROS and RNS production in phagocytes|Cytokine Signaling in Immune system|Disease|Innate Immune System|Immune System|Nitric oxide stimulates guanylate cyclase|Platelet homeostasis|Signaling by Interleukins|Infectious disease|Interleukin-4 and Interleukin-13 signaling|Peroxisomal protein import|Peroxisomal protein import|Protein localization|Protein localization|Infection with Mycobacterium tuberculosis|Inhibition of nitric oxide production|Suppression of phagosomal maturation|Response of Mtb to phagocytosis|Bacterial Infection Pathways"]
["NPC1",59.0635981050358,59.1656805676132,52.1039916376741,51.145100020972,60.7683793272639,57.1731690705932,51.7728862603465,52.6153909506904,58.6702945771037,56.5073866871072,46.9284031275434,53.4969183463578,61.1773711443691,55.6672516569654,57.7247042999309,59.6925270846376,33.7770556063163,35.7214399129786,30.0807800092651,36.5565543327513,30.8625915674871,32.0097497407814,30.9710870054618,33.2345500053055,34.8268651541891,29.0692268197654,29.8872124493017,30.5574304170291,4864,"NPC intracellular cholesterol transporter 1","protein_coding","hsa04142,hsa04979","Lysosome|Cholesterol metabolism","GO:0001618,GO:0001889,GO:0004888,GO:0005515,GO:0005576,GO:0005635,GO:0005764,GO:0005765,GO:0005783,GO:0005794,GO:0005886,GO:0006486,GO:0006897,GO:0006914,GO:0007041,GO:0007628,GO:0008203,GO:0008206,GO:0009410,GO:0010467,GO:0010878,GO:0012501,GO:0015248,GO:0015485,GO:0016020,GO:0016236,GO:0016242,GO:0022008,GO:0030299,GO:0030301,GO:0031579,GO:0031902,GO:0032367,GO:0033344,GO:0038023,GO:0042632,GO:0045121,GO:0046686,GO:0046718,GO:0048471,GO:0070062,GO:0071383,GO:0071404,GO:0090150,GO:1904036,GO:1904262,GO:2000900","virus receptor activity|liver development|transmembrane signaling receptor activity|protein binding|extracellular region|nuclear envelope|lysosome|lysosomal membrane|endoplasmic reticulum|Golgi apparatus|plasma membrane|protein glycosylation|endocytosis|autophagy|lysosomal transport|adult walking behavior|cholesterol metabolic process|bile acid metabolic process|response to xenobiotic stimulus|gene expression|cholesterol storage|programmed cell death|sterol transporter activity|cholesterol binding|membrane|macroautophagy|negative regulation of macroautophagy|neurogenesis|intestinal cholesterol absorption|cholesterol transport|membrane raft organization|late endosome membrane|intracellular cholesterol transport|cholesterol efflux|signaling receptor activity|cholesterol homeostasis|membrane raft|response to cadmium ion|viral entry into host cell|perinuclear region of cytoplasm|extracellular exosome|cellular response to steroid hormone stimulus|cellular response to low-density lipoprotein particle stimulus|establishment of protein localization to membrane|negative regulation of epithelial cell apoptotic process|negative regulation of TORC1 signaling|cyclodextrin metabolic process","WP5323,WP5064,WP4153,WP5304,WP4217","Fatty Acids and Lipoproteins Transport in Hepatocytes|7-oxo-C and 7-beta-HC pathways|Degradation pathway of sphingolipids, including diseases|Cholesterol metabolism|Ebola virus infection in host","R-HSA-174824,R-HSA-382551,R-HSA-8964038,R-HSA-8964043","Plasma lipoprotein assembly, remodeling, and clearance|Transport of small molecules|LDL clearance|Plasma lipoprotein clearance"]
["NPHP1",1.59661689448626,1.611453805355,1.64885719632763,1.94808840292532,1.34345976214532,1.6409056215722,1.93651788728342,1.23511406648416,1.73981184378695,1.26436951990058,1.96866727074064,1.90082294907431,1.87265449553107,1.81815793776512,1.8395577003062,1.98480634166721,1.90175692152099,1.58398679107998,2.28722244671999,2.10682858053527,1.72464298252667,2.17528859321377,2.5219397865865,2.20978890612274,2.03141793087735,1.85420061159311,2.17160700951654,1.71781639323375,4867,"nephrocystin 1","protein_coding",null,null,"GO:0005198,GO:0005515,GO:0005737,GO:0005829,GO:0005856,GO:0005911,GO:0005912,GO:0005923,GO:0005929,GO:0007165,GO:0007632,GO:0016020,GO:0030030,GO:0030036,GO:0031514,GO:0032391,GO:0048515,GO:0060041,GO:0090251,GO:0098609,GO:1903348","structural molecule activity|protein binding|cytoplasm|cytosol|cytoskeleton|cell-cell junction|adherens junction|bicellular tight junction|cilium|signal transduction|visual behavior|membrane|cell projection organization|actin cytoskeleton organization|motile cilium|photoreceptor connecting cilium|spermatid differentiation|retina development in camera-type eye|protein localization involved in establishment of planar polarity|cell-cell adhesion|positive regulation of bicellular tight junction assembly","WP4656,WP5399,WP4803","Joubert syndrome|NPHP1 deletion syndrome|Ciliopathies","R-HSA-1852241,R-HSA-5617833,R-HSA-5620912","Organelle biogenesis and maintenance|Cilium Assembly|Anchoring of the basal body to the plasma membrane"]
["NPM1",396.435408930115,359.738211264431,448.950599573553,403.076053978224,353.227278941443,364.742123350867,460.969460413191,397.851068640431,346.320128110037,254.928614784385,351.870447687308,354.526461081228,364.437308650713,326.2692298576,387.07984590361,336.800398883413,476.591194782937,400.09008072402,537.283724198737,417.04233779876,484.584285249747,441.261855263345,663.942744158393,559.094556477735,489.543647821251,453.477445993187,688.245450857737,472.742130597591,4869,"nucleophosmin 1","protein_coding",null,null,"GO:0000055,GO:0000056,GO:0001046,GO:0001558,GO:0001652,GO:0003682,GO:0003713,GO:0003723,GO:0004860,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005813,GO:0005829,GO:0005925,GO:0006281,GO:0006334,GO:0006338,GO:0006407,GO:0006884,GO:0006886,GO:0006913,GO:0007098,GO:0007165,GO:0008104,GO:0008284,GO:0008285,GO:0010824,GO:0010825,GO:0010826,GO:0015934,GO:0015935,GO:0016020,GO:0016607,GO:0019843,GO:0019901,GO:0030957,GO:0031398,GO:0031616,GO:0032071,GO:0032991,GO:0032993,GO:0034644,GO:0042255,GO:0042273,GO:0042274,GO:0042393,GO:0042803,GO:0043023,GO:0043024,GO:0043066,GO:0043516,GO:0044387,GO:0045727,GO:0045893,GO:0045944,GO:0046599,GO:0048025,GO:0050821,GO:0051059,GO:0051082,GO:0051092,GO:0060699,GO:0060735,GO:0090398,GO:0140297,GO:0140693,GO:1902629,GO:1902751,GO:1904751,GO:1990904","ribosomal large subunit export from nucleus|ribosomal small subunit export from nucleus|core promoter sequence-specific DNA binding|regulation of cell growth|granular component|chromatin binding|transcription coactivator activity|RNA binding|protein kinase inhibitor activity|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|centrosome|cytosol|focal adhesion|DNA repair|nucleosome assembly|chromatin remodeling|rRNA export from nucleus|cell volume homeostasis|intracellular protein transport|nucleocytoplasmic transport|centrosome cycle|signal transduction|protein localization|positive regulation of cell population proliferation|negative regulation of cell population proliferation|regulation of centrosome duplication|positive regulation of centrosome duplication|negative regulation of centrosome duplication|large ribosomal subunit|small ribosomal subunit|membrane|nuclear speck|rRNA binding|protein kinase binding|Tat protein binding|positive regulation of protein ubiquitination|spindle pole centrosome|regulation of endodeoxyribonuclease activity|protein-containing complex|protein-DNA complex|cellular response to UV|ribosome assembly|ribosomal large subunit biogenesis|ribosomal small subunit biogenesis|histone binding|protein homodimerization activity|ribosomal large subunit binding|ribosomal small subunit binding|negative regulation of apoptotic process|regulation of DNA damage response, signal transduction by p53 class mediator|negative regulation of protein kinase activity by regulation of protein phosphorylation|positive regulation of translation|positive regulation of DNA-templated transcription|positive regulation of transcription by RNA polymerase II|regulation of centriole replication|negative regulation of mRNA splicing, via spliceosome|protein stabilization|NF-kappaB binding|unfolded protein binding|positive regulation of NF-kappaB transcription factor activity|regulation of endoribonuclease activity|regulation of eIF2 alpha phosphorylation by dsRNA|cellular senescence|DNA-binding transcription factor binding|molecular condensate scaffold activity|regulation of mRNA stability involved in cellular response to UV|positive regulation of cell cycle G2/M phase transition|positive regulation of protein localization to nucleolus|ribonucleoprotein complex",null,null,"R-HSA-162906,R-HSA-162906,R-HSA-162909,R-HSA-162909,R-HSA-1640170,R-HSA-1643685,R-HSA-1643685,R-HSA-177243,R-HSA-177243,R-HSA-180746,R-HSA-180746,R-HSA-212436,R-HSA-2990846,R-HSA-3108232,R-HSA-3700989,R-HSA-3899300,R-HSA-392499,R-HSA-5663202,R-HSA-5663205,R-HSA-5663205,R-HSA-597592,R-HSA-606279,R-HSA-6791312,R-HSA-6804115,R-HSA-73857,R-HSA-73886,R-HSA-74160,R-HSA-774815,R-HSA-8864260,R-HSA-8869496,R-HSA-9678108,R-HSA-9679506,R-HSA-9692914,R-HSA-9700206,R-HSA-9700645,R-HSA-9725370,R-HSA-9725371,R-HSA-9824446,R-HSA-9824446","HIV Infection|HIV Infection|Host Interactions of HIV factors|Host Interactions of HIV factors|Cell Cycle|Disease|Disease|Interactions of Rev with host cellular proteins|Interactions of Rev with host cellular proteins|Nuclear import of Rev protein|Nuclear import of Rev protein|Generic Transcription Pathway|SUMOylation|SUMO E3 ligases SUMOylate target proteins|Transcriptional Regulation by TP53|SUMOylation of transcription cofactors|Metabolism of proteins|Diseases of signal transduction by growth factor receptors and second messengers|Infectious disease|Infectious disease|Post-translational protein modification|Deposition of new CENPA-containing nucleosomes at the centromere|TP53 Regulates Transcription of Cell Cycle Genes|TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain|RNA Polymerase II Transcription|Chromosome Maintenance|Gene expression (Transcription)|Nucleosome assembly|Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors|TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation|SARS-CoV-1 Infection|SARS-CoV Infections|SARS-CoV-1-host interactions|Signaling by ALK in cancer|ALK mutants bind TKIs|Signaling by ALK fusions and activated point mutants|Nuclear events stimulated by ALK signaling in cancer|Viral Infection Pathways|Viral Infection Pathways"]
["NR1H3",4.53345978485247,4.32996482940513,5.4570865637134,5.21381396625891,4.39314336222748,5.89111803837029,4.82639496170827,5.82894980874525,4.76818088179245,5.0094719331745,5.20990887209909,4.44748441801289,3.9445529165429,5.76578751449108,4.40852798547404,4.38758711779353,4.03310487404208,4.72550895245669,4.17253465732139,3.95246651172027,4.50084916245463,4.18405653055533,3.67698556898989,3.70314031955438,4.12158333202803,4.65614264122787,4.2686256563952,5.19041565182512,10062,"nuclear receptor subfamily 1 group H member 3","protein_coding","hsa03320,hsa05160,hsa04932,hsa04931","PPAR signaling pathway|Hepatitis C|Non-alcoholic fatty liver disease|Insulin resistance","GO:0000122,GO:0000785,GO:0000976,GO:0000978,GO:0000981,GO:0001228,GO:0003677,GO:0004879,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0008270,GO:0009755,GO:0010745,GO:0010867,GO:0010875,GO:0010887,GO:0015485,GO:0030154,GO:0030522,GO:0031490,GO:0032369,GO:0032376,GO:0032411,GO:0032570,GO:0032810,GO:0034145,GO:0036151,GO:0042632,GO:0042752,GO:0042789,GO:0043031,GO:0043235,GO:0043277,GO:0045723,GO:0045861,GO:0045893,GO:0045944,GO:0046889,GO:0048550,GO:0050728,GO:0051006,GO:0051247,GO:0055088,GO:0055092,GO:0060336,GO:0070328,GO:0071222,GO:0090188,GO:0090341,GO:0090575,GO:0120163,GO:1903573","negative regulation of transcription by RNA polymerase II|chromatin|transcription cis-regulatory region binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA binding|nuclear receptor activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|zinc ion binding|hormone-mediated signaling pathway|negative regulation of macrophage derived foam cell differentiation|positive regulation of triglyceride biosynthetic process|positive regulation of cholesterol efflux|negative regulation of cholesterol storage|cholesterol binding|cell differentiation|intracellular receptor signaling pathway|chromatin DNA binding|negative regulation of lipid transport|positive regulation of cholesterol transport|positive regulation of transporter activity|response to progesterone|sterol response element binding|positive regulation of toll-like receptor 4 signaling pathway|phosphatidylcholine acyl-chain remodeling|cholesterol homeostasis|regulation of circadian rhythm|mRNA transcription by RNA polymerase II|negative regulation of macrophage activation|receptor complex|apoptotic cell clearance|positive regulation of fatty acid biosynthetic process|negative regulation of proteolysis|positive regulation of DNA-templated transcription|positive regulation of transcription by RNA polymerase II|positive regulation of lipid biosynthetic process|negative regulation of pinocytosis|negative regulation of inflammatory response|positive regulation of lipoprotein lipase activity|positive regulation of protein metabolic process|lipid homeostasis|sterol homeostasis|negative regulation of type II interferon-mediated signaling pathway|triglyceride homeostasis|cellular response to lipopolysaccharide|negative regulation of pancreatic juice secretion|negative regulation of secretion of lysosomal enzymes|RNA polymerase II transcription regulator complex|negative regulation of cold-induced thermogenesis|negative regulation of response to endoplasmic reticulum stress","WP4149,WP2011,WP299,WP2878,WP4718,WP236,WP170,WP4754,WP2882,WP5381,WP3594,WP5329,WP4396,WP3942,WP2874,WP3915","White fat cell differentiation|SREBF and miR33 in cholesterol and lipid homeostasis|Nuclear receptors in lipid metabolism and toxicity|PPAR-alpha pathway|Cholesterol metabolism with Bloch and Kandutsch-Russell pathways|Adipogenesis|Nuclear receptors|IL-18 signaling pathway|Nuclear receptors meta-pathway|Smith-Magenis and Potocki-Lupski syndrome copy number variation|Circadian rhythm genes|Cholesterol biosynthesis pathway in hepatocytes|Nonalcoholic fatty liver disease|PPAR signaling pathway|Liver X receptor pathway|Angiopoietin-like protein 8 regulatory pathway","R-HSA-1430728,R-HSA-162582,R-HSA-174824,R-HSA-1989781,R-HSA-212436,R-HSA-2990846,R-HSA-3108232,R-HSA-382551,R-HSA-383280,R-HSA-392499,R-HSA-400206,R-HSA-4090294,R-HSA-556833,R-HSA-597592,R-HSA-73857,R-HSA-74160,R-HSA-8866427,R-HSA-8964043,R-HSA-9006931,R-HSA-9024446,R-HSA-9029558,R-HSA-9029569,R-HSA-9031525,R-HSA-9031528,R-HSA-9623433,R-HSA-9632974","Metabolism|Signal Transduction|Plasma lipoprotein assembly, remodeling, and clearance|PPARA activates gene expression|Generic Transcription Pathway|SUMOylation|SUMO E3 ligases SUMOylate target proteins|Transport of small molecules|Nuclear Receptor transcription pathway|Metabolism of proteins|Regulation of lipid metabolism by PPARalpha|SUMOylation of intracellular receptors|Metabolism of lipids|Post-translational protein modification|RNA Polymerase II Transcription|Gene expression (Transcription)|VLDLR internalisation and degradation|Plasma lipoprotein clearance|Signaling by Nuclear Receptors|NR1H2 and NR1H3-mediated signaling|NR1H2 & NR1H3 regulate gene expression linked to lipogenesis|NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux|NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake |NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose|NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis|NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis ","Ecdysone_rcpt"]
["NRAS",18.7434802190502,17.1821257607837,16.0233777404104,14.4681216947212,17.5846747187405,15.6935189156994,16.6852123086346,14.6158502180144,19.0790393924742,10.808618795734,13.9587413597227,15.0584146337061,19.0396777491384,12.1368419943981,17.6283614348152,16.6668454030747,17.846983852493,16.1203920136174,18.5555538721487,19.5041678534302,18.7320628780111,17.7749078103236,26.4825356887887,20.1868852978384,17.8228562424684,16.2584356728891,21.9304831471129,14.9966298703433,4893,"NRAS proto-oncogene%2C GTPase","protein_coding","hsa04010,hsa04012,hsa04014,hsa04015,hsa04370,hsa04371,hsa04068,hsa04072,hsa04071,hsa04151,hsa04150,hsa04140,hsa04137,hsa04210,hsa04218,hsa04540,hsa04550,hsa04810,hsa04625,hsa04650,hsa04660,hsa04662,hsa04664,hsa04062,hsa04910,hsa04929,hsa04912,hsa04915,hsa04917,hsa04921,hsa04926,hsa04935,hsa04919,hsa04916,hsa04725,hsa04726,hsa04720,hsa04730,hsa04722,hsa04360,hsa04211,hsa04213,hsa04714,hsa05200,hsa05206,hsa05205,hsa05207,hsa05208,hsa05203,hsa05230,hsa05231,hsa05235,hsa05210,hsa05225,hsa05226,hsa05214,hsa05216,hsa05221,hsa05220,hsa05218,hsa05211,hsa05219,hsa05215,hsa05213,hsa05224,hsa05223,hsa05166,hsa05170,hsa05161,hsa05160,hsa05163,hsa05167,hsa05165,hsa05010,hsa05022,hsa05034,hsa05417,hsa04933,hsa01521,hsa01522","MAPK signaling pathway|ErbB signaling pathway|Ras signaling pathway|Rap1 signaling pathway|VEGF signaling pathway|Apelin signaling pathway|FoxO signaling pathway|Phospholipase D signaling pathway|Sphingolipid signaling pathway|PI3K-Akt signaling pathway|mTOR signaling pathway|Autophagy - animal|Mitophagy - animal|Apoptosis|Cellular senescence|Gap junction|Signaling pathways regulating pluripotency of stem cells|Regulation of actin cytoskeleton|C-type lectin receptor signaling pathway|Natural killer cell mediated cytotoxicity|T cell receptor signaling pathway|B cell receptor signaling pathway|Fc epsilon RI signaling pathway|Chemokine signaling pathway|Insulin signaling pathway|GnRH secretion|GnRH signaling pathway|Estrogen signaling pathway|Prolactin signaling pathway|Oxytocin signaling pathway|Relaxin signaling pathway|Growth hormone synthesis, secretion and action|Thyroid hormone signaling pathway|Melanogenesis|Cholinergic synapse|Serotonergic synapse|Long-term potentiation|Long-term depression|Neurotrophin signaling pathway|Axon guidance|Longevity regulating pathway|Longevity regulating pathway - multiple species|Thermogenesis|Pathways in cancer|MicroRNAs in cancer|Proteoglycans in cancer|Chemical carcinogenesis - receptor activation|Chemical carcinogenesis - reactive oxygen species|Viral carcinogenesis|Central carbon metabolism in cancer|Choline metabolism in cancer|PD-L1 expression and PD-1 checkpoint pathway in cancer|Colorectal cancer|Hepatocellular carcinoma|Gastric cancer|Glioma|Thyroid cancer|Acute myeloid leukemia|Chronic myeloid leukemia|Melanoma|Renal cell carcinoma|Bladder cancer|Prostate cancer|Endometrial cancer|Breast cancer|Non-small cell lung cancer|Human T-cell leukemia virus 1 infection|Human immunodeficiency virus 1 infection|Hepatitis B|Hepatitis C|Human cytomegalovirus infection|Kaposi sarcoma-associated herpesvirus infection|Human papillomavirus infection|Alzheimer disease|Pathways of neurodegeneration - multiple diseases|Alcoholism|Lipid and atherosclerosis|AGE-RAGE signaling pathway in diabetic complications|EGFR tyrosine kinase inhibitor resistance|Endocrine resistance","GO:0000139,GO:0000165,GO:0001938,GO:0003924,GO:0003925,GO:0005515,GO:0005525,GO:0005789,GO:0005794,GO:0005829,GO:0005886,GO:0007265,GO:0016020,GO:0019003,GO:0044877,GO:0045445,GO:0070062,GO:0070821","Golgi membrane|MAPK cascade|positive regulation of endothelial cell proliferation|GTPase activity|G protein activity|protein binding|GTP binding|endoplasmic reticulum membrane|Golgi apparatus|cytosol|plasma membrane|Ras protein signal transduction|membrane|GDP binding|protein-containing complex binding|myoblast differentiation|extracellular exosome|tertiary granule membrane","WP4871,WP4205,WP5124,WP35,WP4321,WP4666,WP4262,WP732,WP4806,WP4223,WP2828,WP4685,WP673,WP2261,WP2870,WP4483,WP2059,WP2643,WP2586,WP3844,WP51,WP4301,WP3929,WP5358,WP3932,WP382,WP710,WP3676,WP4535,WP422,WP3303,WP4674,WP2290,WP4541,WP231,WP4255,WP4155,WP4539,WP4341,WP4172","Kisspeptin/kisspeptin receptor system in the ovary|MET in type 1 papillary renal cell carcinoma|Alzheimer's disease|G protein signaling pathways|Thermogenesis|Hepatitis B infection|Breast cancer pathway|Serotonin receptor 2 and ELK-SRF/GATA4 signaling|EGFR tyrosine kinase inhibitor resistance|Ras signaling|Bladder cancer|Melanoma|ErbB signaling pathway|Glioblastoma signaling pathways|Extracellular vesicle-mediated signaling in recipient cells|Relationship between inflammation, COX-2 and EGFR|Alzheimer's disease and miRNA effects|Nanoparticle-mediated activation of receptor signaling|Aryl hydrocarbon receptor pathway|PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer|Regulation of actin cytoskeleton|Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells|Chemokine signaling pathway|JAK-STAT signaling in the regulation of Beta-cells|Focal adhesion: PI3K-Akt-mTOR-signaling pathway|MAPK signaling pathway|DNA damage response (only ATM dependent)|BDNF-TrkB signaling|Envelope proteins and their potential roles in EDMD physiopathology|MAPK cascade|RAC1/PAK1/p38/MMP2 pathway|Head and neck squamous cell carcinoma|RalA downstream regulated genes|Hippo-Merlin signaling dysregulation|TNF-alpha signaling pathway|Non-small cell lung cancer|Endometrial cancer|Synaptic signaling pathways associated with autism spectrum disorder|Non-genomic actions of 1,25 dihydroxyvitamin D3|PI3K-Akt signaling pathway","R-HSA-109582,R-HSA-112314,R-HSA-112315,R-HSA-112316,R-HSA-112399,R-HSA-112412,R-HSA-1168372,R-HSA-1169092,R-HSA-1226099,R-HSA-1227986,R-HSA-1227986,R-HSA-1227990,R-HSA-1236382,R-HSA-1236394,R-HSA-1250196,R-HSA-1250347,R-HSA-1266738,R-HSA-1280215,R-HSA-1280218,R-HSA-1433557,R-HSA-162582,R-HSA-162582,R-HSA-1643685,R-HSA-1643713,R-HSA-166520,R-HSA-166520,R-HSA-167044,R-HSA-167044,R-HSA-168249,R-HSA-168256,R-HSA-171007,R-HSA-171007,R-HSA-177929,R-HSA-179812,R-HSA-180336,R-HSA-186763,R-HSA-186797,R-HSA-187037,R-HSA-187037,R-HSA-187687,R-HSA-187687,R-HSA-190236,R-HSA-194138,R-HSA-1963640,R-HSA-1963640,R-HSA-202733,R-HSA-210993,R-HSA-2172127,R-HSA-2179392,R-HSA-2404192,R-HSA-2424491,R-HSA-2428924,R-HSA-2428928,R-HSA-2428933,R-HSA-2454202,R-HSA-2871796,R-HSA-372790,R-HSA-375165,R-HSA-388396,R-HSA-416476,R-HSA-422475,R-HSA-438064,R-HSA-4420097,R-HSA-442742,R-HSA-442755,R-HSA-442982,R-HSA-5218921,R-HSA-5621481,R-HSA-5621575,R-HSA-5637810,R-HSA-5637812,R-HSA-5637815,R-HSA-5654687,R-HSA-5654688,R-HSA-5654693,R-HSA-5654696,R-HSA-5654699,R-HSA-5654700,R-HSA-5654704,R-HSA-5654706,R-HSA-5654708,R-HSA-5654712,R-HSA-5654716,R-HSA-5654719,R-HSA-5654736,R-HSA-5654738,R-HSA-5654741,R-HSA-5654743,R-HSA-5655253,R-HSA-5655291,R-HSA-5655302,R-HSA-5655332,R-HSA-5658442,R-HSA-5663202,R-HSA-5673000,R-HSA-5673001,R-HSA-5674135,R-HSA-5675221,R-HSA-5683057,R-HSA-5684996,R-HSA-6798695,R-HSA-6802946,R-HSA-6802948,R-HSA-6802949,R-HSA-6802952,R-HSA-6802953,R-HSA-6802955,R-HSA-6802957,R-HSA-6806834,R-HSA-74751,R-HSA-74752,R-HSA-881907,R-HSA-8848021,R-HSA-8849471,R-HSA-8851805,R-HSA-8939211,R-HSA-9006115,R-HSA-9006335,R-HSA-9006927,R-HSA-9006931,R-HSA-9006934,R-HSA-9006934,R-HSA-9009391,R-HSA-9026519,R-HSA-9027284,R-HSA-9028731,R-HSA-9034015,R-HSA-9034864,R-HSA-9607240,R-HSA-9634285,R-HSA-9634635,R-HSA-9648002,R-HSA-9649913,R-HSA-9649948,R-HSA-9656223,R-HSA-9664565,R-HSA-9665348,R-HSA-9665686,R-HSA-9669938,R-HSA-9670439,R-HSA-9671555,R-HSA-9673767,R-HSA-9673770,R-HSA-9675108,R-HSA-9682385,R-HSA-9703465,R-HSA-9703648,R-HSA-9753510,R-HSA-9753512,R-HSA-983705","Hemostasis|Neurotransmitter receptors and postsynaptic signal transmission|Transmission across Chemical Synapses|Neuronal System|IRS-mediated signalling|SOS-mediated signalling|Downstream signaling events of B Cell Receptor (BCR)|Activation of RAS in B cells|Signaling by FGFR in disease|Signaling by ERBB2|Signaling by ERBB2|Signaling by ERBB2 in Cancer|Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants|Signaling by ERBB4|SHC1 events in ERBB2 signaling|SHC1 events in ERBB4 signaling|Developmental Biology|Cytokine Signaling in Immune system|Adaptive Immune System|Signaling by SCF-KIT|Signal Transduction|Signal Transduction|Disease|Signaling by EGFR in Cancer|Signaling by NTRKs|Signaling by NTRKs|Signalling to RAS|Signalling to RAS|Innate Immune System|Immune System|p38MAPK events|p38MAPK events|Signaling by EGFR|GRB2 events in EGFR signaling|SHC1 events in EGFR signaling|Downstream signal transduction|Signaling by PDGF|Signaling by NTRK1 (TRKA)|Signaling by NTRK1 (TRKA)|Signalling to ERKs|Signalling to ERKs|Signaling by FGFR|Signaling by VEGF|GRB2 events in ERBB2 signaling|GRB2 events in ERBB2 signaling|Cell surface interactions at the vascular wall|Tie2 Signaling|DAP12 interactions|EGFR Transactivation by Gastrin|Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)|DAP12 signaling|IGF1R signaling cascade|IRS-related events triggered by IGF1R|SHC-related events triggered by IGF1R|Fc epsilon receptor (FCERI) signaling|FCERI mediated MAPK activation|Signaling by GPCR|NCAM signaling for neurite out-growth|GPCR downstream signalling|G alpha (q) signalling events|Axon guidance|Post NMDA receptor activation events|VEGFA-VEGFR2 Pathway|CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling|Activation of NMDA receptors and postsynaptic events|Ras activation upon Ca2+ influx through NMDA receptor|VEGFR2 mediated cell proliferation|C-type lectin receptors (CLRs)|CD209 (DC-SIGN) signaling|Constitutive Signaling by EGFRvIII|Signaling by EGFRvIII in Cancer|Signaling by Ligand-Responsive EGFR Variants in Cancer|Downstream signaling of activated FGFR1|SHC-mediated cascade:FGFR1|FRS-mediated FGFR1 signaling|Downstream signaling of activated FGFR2|SHC-mediated cascade:FGFR2|FRS-mediated FGFR2 signaling|SHC-mediated cascade:FGFR3|FRS-mediated FGFR3 signaling|Downstream signaling of activated FGFR3|FRS-mediated FGFR4 signaling|Downstream signaling of activated FGFR4|SHC-mediated cascade:FGFR4|Signaling by FGFR1|Signaling by FGFR2|Signaling by FGFR3|Signaling by FGFR4|Signaling by FGFR2 in disease|Signaling by FGFR4 in disease|Signaling by FGFR1 in disease|Signaling by FGFR3 in disease|Regulation of RAS by GAPs|Diseases of signal transduction by growth factor receptors and second messengers|RAF activation|RAF/MAP kinase cascade|MAP2K and MAPK activation|Negative regulation of MAPK pathway|MAPK family signaling cascades|MAPK1/MAPK3 signaling|Neutrophil degranulation|Signaling by moderate kinase activity BRAF mutants|Signaling by high-kinase activity BRAF mutants|Signaling by RAS mutants|Signaling by BRAF and RAF1 fusions|RAS signaling downstream of NF1 loss-of-function variants|Paradoxical activation of RAF signaling by kinase inactive BRAF|Oncogenic MAPK signaling|Signaling by MET|Insulin receptor signalling cascade|Signaling by Insulin receptor|Gastrin-CREB signalling pathway via PKC and MAPK|Signaling by PTK6|PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases|MET activates RAS signaling|ESR-mediated signaling|Signaling by NTRK2 (TRKB)|Signaling by Erythropoietin|Signaling by Non-Receptor Tyrosine Kinases|Signaling by Nuclear Receptors|Signaling by Receptor Tyrosine Kinases|Signaling by Receptor Tyrosine Kinases|Extra-nuclear estrogen signaling|Activated NTRK2 signals through RAS|Erythropoietin activates RAS|Activated NTRK2 signals through FRS2 and FRS3|Signaling by NTRK3 (TRKC)|Activated NTRK3 signals through RAS|FLT3 Signaling|Constitutive Signaling by Overexpressed ERBB2|Estrogen-stimulated signaling through PRKCZ|RAS processing|RAS GTPase cycle mutants|Signaling downstream of RAS mutants|Signaling by RAF1 mutants|Signaling by ERBB2 KD Mutants|Signaling by ERBB2 ECD mutants|Signaling by ERBB2 TMD/JMD mutants|Signaling by KIT in disease|Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants|Signaling by PDGFR in disease|Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants|Signaling by PDGFRA extracellular domain mutants|Nervous system development|FLT3 signaling in disease|Signaling by FLT3 fusion proteins|Signaling by FLT3 ITD and TKD mutants|Signaling by RAS GAP mutants|Signaling by RAS GTPase mutants|Signaling by the B Cell Receptor (BCR)"]
["NRF1",4.27899692780157,3.86095882448496,3.84530306322065,3.94218455543254,3.67291808503871,3.79114057058766,3.36334695517354,3.48466773599302,4.20091060163098,4.87630949388734,4.23775989123471,4.12073591990882,3.72785813979101,3.50669323739368,4.17023842869309,4.07103338783041,3.80403771939299,4.52190040567371,5.13980792157248,4.43183727247126,4.18396720887459,4.79863050706936,4.57151570402188,4.68154572017373,3.68295297118863,4.49049964147533,4.54485105929844,4.31205973013641,4899,"nuclear respiratory factor 1","protein_coding","hsa04371,hsa05016","Apelin signaling pathway|Huntington disease","GO:0000978,GO:0000981,GO:0001228,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006357,GO:0042803,GO:0045944,GO:0070062","RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|protein binding|nucleus|nucleoplasm|cytosol|regulation of transcription by RNA polymerase II|protein homodimerization activity|positive regulation of transcription by RNA polymerase II|extracellular exosome","WP391,WP3670,WP5294,WP1541","Mitochondrial gene expression|Interactions between LOXL4 and oxidative stress pathway|Sildenafil treatment|Energy metabolism","R-HSA-1430728,R-HSA-1592230,R-HSA-1592230,R-HSA-1852241,R-HSA-1852241,R-HSA-1989781,R-HSA-2151201,R-HSA-2151201,R-HSA-400206,R-HSA-556833","Metabolism|Mitochondrial biogenesis|Mitochondrial biogenesis|Organelle biogenesis and maintenance|Organelle biogenesis and maintenance|PPARA activates gene expression|Transcriptional activation of mitochondrial biogenesis|Transcriptional activation of mitochondrial biogenesis|Regulation of lipid metabolism by PPARalpha|Metabolism of lipids","Nrf1"]
["NSG1",11.8899229620419,10.1456982729745,7.29402898857026,9.46830133085356,12.0797100322784,9.41185695426766,7.28866684645794,9.69146470981482,16.0937177367373,15.0172005853816,12.7561159188892,16.3779186279067,17.0832777406329,17.7195259535767,11.3769138099505,16.9101796073878,21.4081583561992,18.7062274278189,10.8500712038084,18.1204018456658,21.978739626221,19.1559559406485,8.88822932506624,17.2879034796597,22.9907497133659,20.8413571334734,11.1629824739508,18.2700206358541,27065,"neuronal vesicle trafficking associated 1","protein_coding",null,null,"GO:0001881,GO:0001921,GO:0005515,GO:0005634,GO:0005737,GO:0005768,GO:0005770,GO:0005783,GO:0005789,GO:0006915,GO:0007212,GO:0016197,GO:0016328,GO:0030425,GO:0031901,GO:0032051,GO:0032580,GO:0032585,GO:0032588,GO:0035255,GO:0036477,GO:0042982,GO:0043202,GO:0045211,GO:0048268,GO:0055038,GO:0098814,GO:0098845,GO:0098887,GO:0098978,GO:0099003,GO:0099627,GO:0099630,GO:1900271","receptor recycling|positive regulation of receptor recycling|protein binding|nucleus|cytoplasm|endosome|late endosome|endoplasmic reticulum|endoplasmic reticulum membrane|apoptotic process|dopamine receptor signaling pathway|endosomal transport|lateral plasma membrane|dendrite|early endosome membrane|clathrin light chain binding|Golgi cisterna membrane|multivesicular body membrane|trans-Golgi network membrane|ionotropic glutamate receptor binding|somatodendritic compartment|amyloid precursor protein metabolic process|lysosomal lumen|postsynaptic membrane|clathrin coat assembly|recycling endosome membrane|spontaneous synaptic transmission|postsynaptic endosome|neurotransmitter receptor transport, endosome to postsynaptic membrane|glutamatergic synapse|vesicle-mediated transport in synapse|neurotransmitter receptor cycle|postsynaptic neurotransmitter receptor cycle|regulation of long-term synaptic potentiation"]
["NT5C1A",0,0.00282750695413239,0.00558170703466031,0.00285096816122439,0,0,0,0,0,0,0,0,0.00282698739251329,0,0,0,0,0,0,0.00285858714643954,0.00280576422793615,0,0,0,0,0,0,0,84618,"5'-nucleotidase%2C cytosolic IA","protein_coding","hsa00230,hsa00240,hsa00760","Purine metabolism|Pyrimidine metabolism|Nicotinate and nicotinamide metabolism","GO:0000166,GO:0000255,GO:0000287,GO:0005515,GO:0005737,GO:0005829,GO:0006196,GO:0006204,GO:0008253,GO:0009116,GO:0046055,GO:0046059,GO:0046085,GO:0050483,GO:0106411","nucleotide binding|allantoin metabolic process|magnesium ion binding|protein binding|cytoplasm|cytosol|AMP catabolic process|IMP catabolic process|5'-nucleotidase activity|nucleoside metabolic process|dGMP catabolic process|dAMP catabolic process|adenosine metabolic process|IMP 5'-nucleotidase activity|XMP 5'-nucleosidase activity",null,null,"R-HSA-1430728,R-HSA-15869,R-HSA-73621,R-HSA-74259,R-HSA-8956319","Metabolism|Metabolism of nucleotides|Pyrimidine catabolism|Purine catabolism|Nucleotide catabolism"]
["NUCB1-AS1",30.3802148609668,9.77037518455419,12.3322725073363,20.6581811384527,19.2230746125672,18.0057367751731,12.1974136957956,24.4186426051157,34.8165125298432,20.1462576344885,13.5828563226714,35.638312636294,18.5899034781697,25.4620427129326,14.2425076834134,20.3052051755624,13.4671427729473,5.52978547519819,11.9101532711306,14.3078030260863,7.16860448570173,12.6634999681526,13.7668014062239,18.1854729631517,20.1826346246679,16.9177606379236,11.4460889954718,13.9878261906089,100874085,"NUCB1 antisense RNA 1","non_coding"]
["NUDT11",5.27576493054317,4.12434105922208,3.61383296780804,4.14770486654574,4.33660970079414,3.46582221770549,4.06665836714789,3.56365013819073,5.3522554643841,4.93948657120269,4.40790234129879,4.87502825237623,6.21229114097194,3.98282126522639,5.69609365533141,5.20617999679388,4.94171050556074,4.99670753636825,5.44100154915582,6.54301663779595,5.90919635466843,5.67125397173243,6.16953749345642,5.25382403292542,4.94990878281325,5.51852111961733,6.04743342545526,4.86403876298219,55190,"nudix hydrolase 11","protein_coding",null,null,"GO:0000298,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0008486,GO:0034431,GO:0034432,GO:0046872,GO:0071543,GO:1901907,GO:1901909,GO:1901911","endopolyphosphatase activity|protein binding|nucleus|cytoplasm|cytosol|diphosphoinositol-polyphosphate diphosphatase activity|bis(5'-adenosyl)-hexaphosphatase activity|bis(5'-adenosyl)-pentaphosphatase activity|metal ion binding|diphosphoinositol polyphosphate metabolic process|diadenosine pentaphosphate catabolic process|diadenosine hexaphosphate catabolic process|adenosine 5'-(hexahydrogen pentaphosphate) catabolic process",null,null,"R-HSA-1430728,R-HSA-1483249,R-HSA-1855167","Metabolism|Inositol phosphate metabolism|Synthesis of pyrophosphates in the cytosol"]
["NUGGC",0,0,0,0,0,0,0.00503400828308316,0,0,0,0,0,0,0.00514400541164858,0,0,0,0,0,0,0,0,0,0,0,0,0,0,389643,"nuclear GTPase%2C germinal center associated","protein_coding",null,null,"GO:0003924,GO:0005525,GO:0016607,GO:0033262,GO:0043066,GO:0071222","GTPase activity|GTP binding|nuclear speck|regulation of nuclear cell cycle DNA replication|negative regulation of apoptotic process|cellular response to lipopolysaccharide"]
["NUP98",14.9061268868404,14.4840168485525,11.7048205289711,11.1401293306937,15.1639071701669,13.1496619326207,10.7862809531935,11.2662166860432,13.0152761006737,12.4029974808825,10.2130020810639,11.9960652288695,12.539448554539,10.2752151016768,10.8597903432966,11.6425994698968,12.4568858688317,12.7034296654849,10.2518093820911,13.7452926774921,13.2072025183888,12.0100119689612,10.8763286666228,11.9797882329353,13.2997740736387,10.8485012680162,10.2506473190129,11.1130336385981,4928,"nucleoporin 98 and 96 precursor","protein_coding","hsa03013,hsa05164,hsa05014","Nucleocytoplasmic transport|Influenza A|Amyotrophic lateral sclerosis","GO:0000776,GO:0000973,GO:0003713,GO:0003723,GO:0003729,GO:0005515,GO:0005635,GO:0005643,GO:0005654,GO:0005829,GO:0006405,GO:0006508,GO:0006606,GO:0006913,GO:0006999,GO:0008139,GO:0008236,GO:0016604,GO:0017056,GO:0031080,GO:0031965,GO:0034398,GO:0034399,GO:0042405,GO:0044614,GO:0044615,GO:0045893,GO:0048026,GO:0051028,GO:0051292,GO:1990841,GO:1990904","kinetochore|post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery|transcription coactivator activity|RNA binding|mRNA binding|protein binding|nuclear envelope|nuclear pore|nucleoplasm|cytosol|RNA export from nucleus|proteolysis|protein import into nucleus|nucleocytoplasmic transport|nuclear pore organization|nuclear localization sequence binding|serine-type peptidase activity|nuclear body|structural constituent of nuclear pore|nuclear pore outer ring|nuclear membrane|telomere tethering at nuclear periphery|nuclear periphery|nuclear inclusion body|nuclear pore cytoplasmic filaments|nuclear pore nuclear basket|positive regulation of DNA-templated transcription|positive regulation of mRNA splicing, via spliceosome|mRNA transport|nuclear pore complex assembly|promoter-specific chromatin binding|ribonucleoprotein complex","WP5039,WP3998","SARS-CoV-2 innate immunity evasion and cell-specific immune response|Prader-Willi and Angelman syndrome","R-HSA-1169408,R-HSA-1169410,R-HSA-1280215,R-HSA-141424,R-HSA-141444,R-HSA-1430728,R-HSA-159227,R-HSA-159230,R-HSA-159231,R-HSA-159234,R-HSA-159236,R-HSA-162582,R-HSA-162587,R-HSA-162599,R-HSA-162906,R-HSA-162906,R-HSA-162909,R-HSA-162909,R-HSA-1640170,R-HSA-1640170,R-HSA-1643685,R-HSA-1643685,R-HSA-165054,R-HSA-168255,R-HSA-168256,R-HSA-168271,R-HSA-168273,R-HSA-168274,R-HSA-168276,R-HSA-168325,R-HSA-168333,R-HSA-170822,R-HSA-176033,R-HSA-177243,R-HSA-177243,R-HSA-180746,R-HSA-180910,R-HSA-191859,R-HSA-194315,R-HSA-194441,R-HSA-195258,R-HSA-211000,R-HSA-2262752,R-HSA-2467813,R-HSA-2500257,R-HSA-2555396,R-HSA-2555396,R-HSA-2980766,R-HSA-2990846,R-HSA-2990846,R-HSA-2995410,R-HSA-2995410,R-HSA-3108214,R-HSA-3108232,R-HSA-3108232,R-HSA-3232142,R-HSA-3301854,R-HSA-3371453,R-HSA-3371556,R-HSA-392499,R-HSA-392499,R-HSA-4085377,R-HSA-4551638,R-HSA-4570464,R-HSA-4615885,R-HSA-4615885,R-HSA-5578749,R-HSA-5619102,R-HSA-5619107,R-HSA-5619115,R-HSA-5663205,R-HSA-5663205,R-HSA-5663220,R-HSA-597592,R-HSA-597592,R-HSA-6784531,R-HSA-68875,R-HSA-68877,R-HSA-68882,R-HSA-68882,R-HSA-68886,R-HSA-68886,R-HSA-69278,R-HSA-69278,R-HSA-69618,R-HSA-69620,R-HSA-70171,R-HSA-70326,R-HSA-71387,R-HSA-72202,R-HSA-72203,R-HSA-72306,R-HSA-74160,R-HSA-8953854,R-HSA-8953897,R-HSA-913531,R-HSA-9609646,R-HSA-9609690,R-HSA-9610379,R-HSA-9615933,R-HSA-9615933,R-HSA-9648025,R-HSA-9679506,R-HSA-9694516,R-HSA-9705671,R-HSA-9705683,R-HSA-9716542,R-HSA-9824446,R-HSA-9824446","ISG15 antiviral mechanism|Antiviral mechanism by IFN-stimulated genes|Cytokine Signaling in Immune system|Amplification of signal from the kinetochores|Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal|Metabolism|Transport of the SLBP independent Mature mRNA|Transport of the SLBP Dependant Mature mRNA|Transport of Mature mRNA Derived from an Intronless Transcript|Transport of Mature mRNAs Derived from Intronless Transcripts|Transport of Mature mRNA derived from an Intron-Containing Transcript|Signal Transduction|HIV Life Cycle|Late Phase of HIV Life Cycle|HIV Infection|HIV Infection|Host Interactions of HIV factors|Host Interactions of HIV factors|Cell Cycle|Cell Cycle|Disease|Disease|Rev-mediated nuclear export of HIV RNA|Influenza Infection|Immune System|Transport of Ribonucleoproteins into the Host Nucleus|Influenza Viral RNA Transcription and Replication|Export of Viral Ribonucleoproteins from Nucleus|NS1 Mediated Effects on Host Pathways|Viral Messenger RNA Synthesis|NEP/NS2 Interacts with the Cellular Export Machinery|Regulation of Glucokinase by Glucokinase Regulatory Protein|Interactions of Vpr with host cellular proteins|Interactions of Rev with host cellular proteins|Interactions of Rev with host cellular proteins|Nuclear import of Rev protein|Vpr-mediated nuclear import of PICs|snRNP Assembly|Signaling by Rho GTPases|Metabolism of non-coding RNA|RHO GTPase Effectors|Gene Silencing by RNA|Cellular responses to stress|Separation of Sister Chromatids|Resolution of Sister Chromatid Cohesion|Mitotic Metaphase and Anaphase|Mitotic Metaphase and Anaphase|Nuclear Envelope Breakdown|SUMOylation|SUMOylation|Nuclear Envelope (NE) Reassembly|Nuclear Envelope (NE) Reassembly|SUMOylation of DNA damage response and repair proteins|SUMO E3 ligases SUMOylate target proteins|SUMO E3 ligases SUMOylate target proteins|SUMOylation of ubiquitinylation proteins|Nuclear Pore Complex (NPC) Disassembly|Regulation of HSF1-mediated heat shock response|Cellular response to heat stress|Metabolism of proteins|Metabolism of proteins|SUMOylation of SUMOylation proteins|SUMOylation of chromatin organization proteins|SUMOylation of RNA binding proteins|SUMOylation of DNA replication proteins|SUMOylation of DNA replication proteins|Transcriptional regulation by small RNAs|SLC transporter disorders|Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)|Disorders of transmembrane transporters|Infectious disease|Infectious disease|RHO GTPases Activate Formins|Post-translational protein modification|Post-translational protein modification|tRNA processing in the nucleus|Mitotic Prophase|Mitotic Prometaphase|Mitotic Anaphase|Mitotic Anaphase|M Phase|M Phase|Cell Cycle, Mitotic|Cell Cycle, Mitotic|Mitotic Spindle Checkpoint|Cell Cycle Checkpoints|Glycolysis|Glucose metabolism|Metabolism of carbohydrates|Transport of Mature Transcript to Cytoplasm|Processing of Capped Intron-Containing Pre-mRNA|tRNA processing|Gene expression (Transcription)|Metabolism of RNA|Cellular responses to stimuli|Interferon Signaling|HCMV Infection|HCMV Early Events|HCMV Late Events|Postmitotic nuclear pore complex (NPC) reformation|Postmitotic nuclear pore complex (NPC) reformation|EML4 and NUDC in mitotic spindle formation|SARS-CoV Infections|SARS-CoV-2 Infection|SARS-CoV-2 activates/modulates innate and adaptive immune responses|SARS-CoV-2-host interactions|Signaling by Rho GTPases, Miro GTPases and RHOBTB3|Viral Infection Pathways|Viral Infection Pathways"]
["NXPH4",0.776577945835258,1.60515298381617,1.31795080960891,1.33201655046891,0.554536396218628,1.22008509921492,0.933542194245425,1.25942024006828,1.15667644259302,1.52465527784552,0.997176788441798,1.33722831430449,1.00836212684047,1.11055799493324,1.01387614657796,0.991191729806251,1.03379905962303,1.11926457739858,0.345062451751012,0.531358296412636,1.26860958543116,0.695579462097223,0.545503376852774,0.379347695678415,0.992008967777651,1.17778393267794,0.549158618840922,0.645833915702659,11247,"neurexophilin 4","protein_coding",null,null,"GO:0003674,GO:0005102,GO:0005575,GO:0005576,GO:0007218","molecular_function|signaling receptor binding|cellular_component|extracellular region|neuropeptide signaling pathway"]
["OAS1",0.0849529207413722,0.0994514736875541,0.0858919844199026,0.0438710436368192,0.146868124331842,0.104321313185399,0.17071450926156,0.0897126130134617,0.0657316325503471,0.0125877771367006,0.0184369178298329,0.0525967364209927,0.0497165996127235,0.0124603398965315,0.06077364697628,0.0123920420592227,0.0251314114830919,0.0604645735040611,0.0422774698460513,0.0502723262912267,0,0.0248464253127616,0.0774159092064281,0.0191530794601269,0.0194363765192799,0.0869298283425242,0.0126472894036091,0.0430045403156948,4938,"2'-5'-oligoadenylate synthetase 1","protein_coding","hsa04621,hsa05160,hsa05171,hsa05164,hsa05162,hsa05168,hsa05169","NOD-like receptor signaling pathway|Hepatitis C|Coronavirus disease - COVID-19|Influenza A|Measles|Herpes simplex virus 1 infection|Epstein-Barr virus infection","GO:0001730,GO:0003725,GO:0005515,GO:0005524,GO:0005576,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005783,GO:0005829,GO:0006006,GO:0009615,GO:0016020,GO:0032728,GO:0032760,GO:0034138,GO:0034142,GO:0035458,GO:0042593,GO:0042742,GO:0043129,GO:0045071,GO:0046872,GO:0051607,GO:0060339,GO:0060700,GO:0070106,GO:0071639,GO:0071659,GO:0098586,GO:0140374,GO:2000342","2'-5'-oligoadenylate synthetase activity|double-stranded RNA binding|protein binding|ATP binding|extracellular region|nucleus|nucleoplasm|cytoplasm|mitochondrion|endoplasmic reticulum|cytosol|glucose metabolic process|response to virus|membrane|positive regulation of interferon-beta production|positive regulation of tumor necrosis factor production|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|cellular response to interferon-beta|glucose homeostasis|defense response to bacterium|surfactant homeostasis|negative regulation of viral genome replication|metal ion binding|defense response to virus|negative regulation of type I interferon-mediated signaling pathway|regulation of ribonuclease activity|interleukin-27-mediated signaling pathway|positive regulation of monocyte chemotactic protein-1 production|negative regulation of IP-10 production|cellular response to virus|antiviral innate immune response|negative regulation of chemokine (C-X-C motif) ligand 2 production","WP4197,WP4630,WP619,WP4868,WP4880,WP4705","Immune response to tuberculosis|Measles virus infection|Type II interferon signaling|Type I interferon induction and signaling during SARS-CoV-2 infection|Host-pathogen interaction of human coronaviruses - interferon induction|Pathways of nucleic acid metabolism and innate immune sensing","R-HSA-1169410,R-HSA-1280215,R-HSA-168256,R-HSA-877300,R-HSA-8983711,R-HSA-909733,R-HSA-913531","Antiviral mechanism by IFN-stimulated genes|Cytokine Signaling in Immune system|Immune System|Interferon gamma signaling|OAS antiviral response|Interferon alpha/beta signaling|Interferon Signaling"]
["ODF3B",1.0587897703864,2.17748051465584,2.92835786281458,1.72899415606891,1.70569979622449,1.96164327669247,2.83003181584081,2.46934171397381,1.15135025167805,1.81901397317768,2.77189860684723,1.38192062252608,1.33346174319556,3.00099746711847,2.31530175781449,2.17058061546895,1.9533869793287,2.03875373240206,2.56540379468475,2.28396864569516,2.56587436496589,2.44804548762281,2.57077113573628,2.3483871312576,2.52497513433851,3.42597651509152,1.52301156233748,2.47501107822356,440836,"outer dense fiber of sperm tails 3B","protein_coding",null,null,"GO:0005515,GO:0005856,GO:0031514","protein binding|cytoskeleton|motile cilium"]
["OLFM1",0.232704726341558,0.214200777444215,0.147996840322513,0.143985403987651,0.161373025354627,0.30311060209773,0.0420215628776666,0.206106671501269,1.14769517151399,1.17123114335842,0.825964677213695,0.83074941349991,0.79953595868415,0.75860256471156,0.70509107968512,0.854088111851191,1.03926889591733,1.39606487069213,1.10310440924847,1.21270962544625,1.45244983399599,1.27008408423108,1.05231525150063,1.32740814554138,1.58519319773993,1.7332276461956,0.893472356050706,1.31967328185619,10439,"olfactomedin 1","protein_coding",null,null,"GO:0003190,GO:0005515,GO:0005615,GO:0005783,GO:0007165,GO:0007399,GO:0010628,GO:0010629,GO:0010718,GO:0023041,GO:0030424,GO:0030516,GO:0043025,GO:0043065,GO:0043204,GO:0044295,GO:0045202,GO:0060317","atrioventricular valve formation|protein binding|extracellular space|endoplasmic reticulum|signal transduction|nervous system development|positive regulation of gene expression|negative regulation of gene expression|positive regulation of epithelial to mesenchymal transition|neuronal signal transduction|axon|regulation of axon extension|neuronal cell body|positive regulation of apoptotic process|perikaryon|axonal growth cone|synapse|cardiac epithelial to mesenchymal transition"]
["OR10AD1",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.0266694654286425,0,0,0,0,0,0,0,121275,"olfactory receptor family 10 subfamily AD member 1","protein_coding","hsa04740","Olfactory transduction","GO:0004930,GO:0004984,GO:0005886,GO:0007186,GO:0050911","G protein-coupled receptor activity|olfactory receptor activity|plasma membrane|G protein-coupled receptor signaling pathway|detection of chemical stimulus involved in sensory perception of smell",null,null,"R-HSA-381753,R-HSA-9709957,R-HSA-9752946","Olfactory Signaling Pathway|Sensory Perception|Expression and translocation of olfactory receptors"]
["OR1J1",0,0,0,0,0,0,0,0,0,0,0,0.027987814465505,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,347168,"olfactory receptor family 1 subfamily J member 1","protein_coding","hsa04740","Olfactory transduction","GO:0004930,GO:0004984,GO:0005886,GO:0007165,GO:0007186,GO:0050911","G protein-coupled receptor activity|olfactory receptor activity|plasma membrane|signal transduction|G protein-coupled receptor signaling pathway|detection of chemical stimulus involved in sensory perception of smell",null,null,"R-HSA-381753,R-HSA-9709957,R-HSA-9752946","Olfactory Signaling Pathway|Sensory Perception|Expression and translocation of olfactory receptors"]
["OR2T33",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.00617840456991865,0,0,0,0,0,0,0,391195,"olfactory receptor family 2 subfamily T member 33","protein_coding","hsa04740","Olfactory transduction","GO:0004930,GO:0004984,GO:0005886,GO:0007186,GO:0050911","G protein-coupled receptor activity|olfactory receptor activity|plasma membrane|G protein-coupled receptor signaling pathway|detection of chemical stimulus involved in sensory perception of smell",null,null,"R-HSA-381753,R-HSA-9709957,R-HSA-9752946","Olfactory Signaling Pathway|Sensory Perception|Expression and translocation of olfactory receptors"]
["OR6J1",0,0,0,0.00620710186938362,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,79549,"olfactory receptor family 6 subfamily J member 1","protein_coding","hsa04740","Olfactory transduction","GO:0004930,GO:0004984,GO:0005886,GO:0007186,GO:0050911","G protein-coupled receptor activity|olfactory receptor activity|plasma membrane|G protein-coupled receptor signaling pathway|detection of chemical stimulus involved in sensory perception of smell"]
["ORM2",0,0.033781071225392,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5005,"orosomucoid 2","protein_coding",null,null,"GO:0002682,GO:0005576,GO:0005615,GO:0006953,GO:0031093,GO:0032731,GO:0032732,GO:0032760,GO:0035578,GO:0035580,GO:0062023,GO:0070062,GO:0072562","regulation of immune system process|extracellular region|extracellular space|acute-phase response|platelet alpha granule lumen|positive regulation of interleukin-1 beta production|positive regulation of interleukin-1 production|positive regulation of tumor necrosis factor production|azurophil granule lumen|specific granule lumen|collagen-containing extracellular matrix|extracellular exosome|blood microparticle","WP2877","Vitamin D receptor pathway","R-HSA-109582,R-HSA-114608,R-HSA-168249,R-HSA-168256,R-HSA-6798695,R-HSA-76002,R-HSA-76005","Hemostasis|Platelet degranulation |Innate Immune System|Immune System|Neutrophil degranulation|Platelet activation, signaling and aggregation|Response to elevated platelet cytosolic Ca2+"]
["OSER1",8.244473201119,9.00286480183671,9.42897886640077,9.05702849151446,8.92245008660001,9.15765691188629,9.62201654917994,9.3948244434421,9.61967403678609,7.95285919670958,8.40997634087234,7.99300231373894,8.93604336759316,9.10137851296048,9.68670521871689,8.82814864764813,10.7718883585178,8.5556074603667,10.9565606859642,9.36540730642833,10.2959136539882,9.28595176243003,12.316481861205,10.8747892573397,9.09516808760869,10.3161099998778,13.2455942049952,11.7650477906429,51526,"oxidative stress responsive serine rich 1","protein_coding",null,null,"GO:0070301","cellular response to hydrogen peroxide"]
["OTUD7B",3.30633009594954,3.30583423979433,3.46555106082057,2.99446025473676,3.4395791224296,3.15646000543711,2.99004211364352,2.90820993716495,3.9449038125788,3.30869964053824,3.50728976177068,3.92022240162057,3.8765502211664,3.4062915169749,3.76735327303815,3.46383734696089,3.15036284818432,3.12382107560218,2.61784419469438,3.24249699292149,3.04082134809878,3.16490677135355,2.82761259054123,3.102060886037,3.28636135587016,2.97879941432795,2.81259022668545,3.08645718210646,56957,"OTU deubiquitinase 7B","protein_coding",null,null,"GO:0000122,GO:0001701,GO:0002250,GO:0002385,GO:0003677,GO:0004843,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0008234,GO:0008270,GO:0032717,GO:0035871,GO:0043124,GO:0070530,GO:0070536,GO:0071108,GO:0071947,GO:1900181,GO:1990380","negative regulation of transcription by RNA polymerase II|in utero embryonic development|adaptive immune response|mucosal immune response|DNA binding|cysteine-type deubiquitinase activity|protein binding|nucleus|cytoplasm|cytosol|cysteine-type peptidase activity|zinc ion binding|negative regulation of interleukin-8 production|protein K11-linked deubiquitination|negative regulation of canonical NF-kappaB signal transduction|K63-linked polyubiquitin modification-dependent protein binding|protein K63-linked deubiquitination|protein K48-linked deubiquitination|protein deubiquitination involved in ubiquitin-dependent protein catabolic process|negative regulation of protein localization to nucleus|K48-linked deubiquitinase activity","WP5216,WP231","Warburg effect modulated by deubiquitinating enzymes and their substrates|TNF-alpha signaling pathway","R-HSA-162582,R-HSA-392499,R-HSA-5357786,R-HSA-5357905,R-HSA-5357956,R-HSA-5688426,R-HSA-5689896,R-HSA-597592,R-HSA-73887,R-HSA-75893","Signal Transduction|Metabolism of proteins|TNFR1-induced proapoptotic signaling|Regulation of TNFR1 signaling|TNFR1-induced NF-kappa-B signaling pathway|Deubiquitination|Ovarian tumor domain proteases|Post-translational protein modification|Death Receptor Signaling|TNF signaling"]
["OXSM",1.60129513302189,1.27644190558802,2.51370390911421,1.57925809010092,1.5963926557809,1.02884581747971,1.91134442058719,1.76094060407659,1.65633280434406,1.16761623242213,1.59737846276992,1.23273600986701,1.70777506110173,2.05818114362351,1.72433165031905,1.57973948870051,2.64278731865848,1.75755159094145,2.75019255376099,1.9325919085169,2.03149746182854,2.14448313711335,2.89285639561057,2.57781195114804,2.46811130403554,2.09439779169913,3.35002606226551,2.34038314643237,54995,"3-oxoacyl-ACP synthase%2C mitochondrial","protein_coding","hsa00061,hsa00780","Fatty acid biosynthesis|Biotin metabolism","GO:0004315,GO:0005739,GO:0005829,GO:0006633,GO:0006637,GO:0051790,GO:0051792","3-oxoacyl-[acyl-carrier-protein] synthase activity|mitochondrion|cytosol|fatty acid biosynthetic process|acyl-CoA metabolic process|short-chain fatty acid biosynthetic process|medium-chain fatty acid biosynthetic process","WP4317","Mitochondrial fatty acid synthesis pathway"]
["P4HA3",2.7255064628095,2.4787066993773,2.52513455938302,2.77442314288595,3.08376337409383,2.57061485503476,1.88484878474762,3.20011454956555,3.43888662976816,2.86678948814493,2.5069711439346,2.82627280310974,2.63740497945545,2.88335304313032,2.15672332562164,2.65219924560194,3.83866986372837,3.88226804266928,2.62945239286417,3.72444368560002,3.73460034424132,3.02247673774143,2.14781943225151,2.88464062600692,3.91097820205022,3.63469665543655,2.31352854944069,3.57372225271541,283208,"prolyl 4-hydroxylase subunit alpha 3","protein_coding","hsa00330","Arginine and proline metabolism","GO:0004656,GO:0005506,GO:0005515,GO:0005783,GO:0005788,GO:0018401,GO:0031418","procollagen-proline 4-dioxygenase activity|iron ion binding|protein binding|endoplasmic reticulum|endoplasmic reticulum lumen|peptidyl-proline hydroxylation to 4-hydroxy-L-proline|L-ascorbic acid binding","WP5312","Metabolic pathways of fibroblasts","R-HSA-1474244,R-HSA-1474290,R-HSA-1650814","Extracellular matrix organization|Collagen formation|Collagen biosynthesis and modifying enzymes"]
["PAEP",0,0.0206606229331769,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5047,"progestagen associated endometrial protein","protein_coding",null,null,"GO:0005515,GO:0005576,GO:0006915,GO:0032725,GO:0036094,GO:1902491,GO:2000359","protein binding|extracellular region|apoptotic process|positive regulation of granulocyte macrophage colony-stimulating factor production|small molecule binding|negative regulation of sperm capacitation|regulation of binding of sperm to zona pellucida"]
["PAGR1",9.15704162353638,9.1466828314456,9.929617639811,10.0233799916226,6.75170249577753,7.67108080155169,7.33593006762527,8.17422570542212,7.52397284693974,9.24831199673056,9.61941666586214,8.62469716350945,6.18710345028791,8.58417388780477,6.75585210901781,7.01310730826462,8.46275468154422,10.3075787685211,9.62070456597031,9.02641467760446,8.86618599007454,9.3192133273706,7.9615338351248,9.15691721607838,8.34035787719099,10.823153110691,9.11696865533142,10.2244412610776,79447,"PAXIP1 associated glutamate rich protein 1","protein_coding",null,null,"GO:0005515,GO:0005634,GO:0005654,GO:0006281,GO:0006310,GO:0030331,GO:0033148,GO:0035097,GO:0044666,GO:0045944,GO:1902808","protein binding|nucleus|nucleoplasm|DNA repair|DNA recombination|nuclear estrogen receptor binding|positive regulation of intracellular estrogen receptor signaling pathway|histone methyltransferase complex|MLL3/4 complex|positive regulation of transcription by RNA polymerase II|positive regulation of cell cycle G1/S phase transition","WP4949,WP5351","16p11.2 proximal deletion syndrome|Kleefstra syndrome","R-HSA-1266738,R-HSA-212165,R-HSA-5617472,R-HSA-5619507,R-HSA-74160,R-HSA-9772755","Developmental Biology|Epigenetic regulation of gene expression|Activation of anterior HOX genes in hindbrain development during early embryogenesis|Activation of HOX genes during differentiation|Gene expression (Transcription)|Formation of WDR5-containing histone-modifying complexes"]
["PANK4",5.31624707017695,4.69421220036329,4.5652227047118,4.84917125489827,4.53290268235027,4.7764082356148,4.22644808869874,4.47175638041474,5.39000861708282,6.56484209517379,5.1645707674549,5.2086346281839,4.64733639525486,4.98766550295172,4.73596745255473,4.44422363227257,4.55883917076056,4.90774405929165,4.26497809726965,4.50154166946135,4.5553625028275,4.44390469558585,3.63022773707504,4.07706621893548,4.56909658920249,4.3100605217264,3.88612583312602,4.2075502199961,55229,"pantothenate kinase 4 (inactive)","protein_coding",null,null,"GO:0004594,GO:0005524,GO:0005634,GO:0005829,GO:0015937,GO:0016787,GO:0046872","pantothenate kinase activity|ATP binding|nucleus|cytosol|coenzyme A biosynthetic process|hydrolase activity|metal ion binding","WP5345","1p36 copy number variation syndrome","R-HSA-1430728,R-HSA-196783,R-HSA-196849,R-HSA-196854,R-HSA-199220","Metabolism|Coenzyme A biosynthesis|Metabolism of water-soluble vitamins and cofactors|Metabolism of vitamins and cofactors|Vitamin B5 (pantothenate) metabolism"]
["PAQR4",7.7906975875414,6.42666951561594,4.30745217157672,7.2310193831557,5.53297208741044,4.68554567190746,3.53129025293142,5.63120272426876,6.53368755392207,9.63070435123549,5.24954327035654,7.5047682745945,5.09838174101148,3.19687770809057,2.98775471168304,2.80811288283364,8.11769160719566,9.67939862435123,7.46941331777304,8.37023700836992,8.2913729111953,9.58114249839873,5.92693029282919,7.16011303839942,9.32638420783137,9.88280450709703,6.49939963136588,9.6837438548071,124222,"progestin and adipoQ receptor family member 4","protein_coding",null,null,"GO:0016020,GO:0038023","membrane|signaling receptor activity"]
["PARD6G",2.60707921070782,2.48644887860974,1.89344132755683,1.65116838505364,2.38272840215681,2.13143454663859,1.44893876159662,1.78472204916313,4.93372792024471,4.46692169638523,4.43440075931951,5.44383420415726,5.06554281279598,5.80850470509099,4.74457453811821,5.37023485875923,2.49979254275737,2.32121070272205,1.77953635831593,2.13536161759039,2.58008306500569,2.2643782583898,2.16445679415782,2.52644895902613,2.57775196928666,2.39706929738447,1.89721704801598,2.31882909316202,84552,"par-6 family cell polarity regulator gamma","protein_coding","hsa04015,hsa04390,hsa04144,hsa04530,hsa04360,hsa05165","Rap1 signaling pathway|Hippo signaling pathway|Endocytosis|Tight junction|Axon guidance|Human papillomavirus infection","GO:0005515,GO:0005634,GO:0005829,GO:0005886,GO:0005923,GO:0005938,GO:0007098,GO:0007163,GO:0016324,GO:0045197,GO:0051301,GO:0060341,GO:0070160,GO:0120157","protein binding|nucleus|cytosol|plasma membrane|bicellular tight junction|cell cortex|centrosome cycle|establishment or maintenance of cell polarity|apical plasma membrane|establishment or maintenance of epithelial cell apical/basal polarity|cell division|regulation of cellular localization|tight junction|PAR polarity complex","WP5090","Complement system in neuronal development and plasticity","R-HSA-1500931,R-HSA-420029,R-HSA-421270,R-HSA-446728","Cell-Cell communication|Tight junction interactions|Cell-cell junction organization|Cell junction organization"]
["PAWR",5.03673076027093,4.4943804397512,3.64241342400347,3.8090544617873,5.53564354970756,4.22847044319225,3.64118395149982,3.65666512272647,7.47865479638525,4.87561677683249,4.78959820541449,5.99758656761905,7.7896375983249,4.7678155324669,4.95729325481261,5.6473966547609,6.22257820210085,5.82066049582691,4.62436651157598,6.83777945717793,6.48240853523681,6.54774463254779,6.98702603432684,6.51275477662788,6.90282341182403,5.56725434600436,5.43005690408295,4.95841860874182,5074,"pro-apoptotic WT1 regulator","protein_coding",null,null,"GO:0000122,GO:0000785,GO:0003714,GO:0003779,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0005884,GO:0005886,GO:0006915,GO:0010628,GO:0010629,GO:0015629,GO:0019899,GO:0030889,GO:0042130,GO:0042986,GO:0043065,GO:0043522,GO:0048147,GO:0050860,GO:0051017,GO:0097190,GO:1901300,GO:2000774","negative regulation of transcription by RNA polymerase II|chromatin|transcription corepressor activity|actin binding|protein binding|nucleus|cytoplasm|cytosol|actin filament|plasma membrane|apoptotic process|positive regulation of gene expression|negative regulation of gene expression|actin cytoskeleton|enzyme binding|negative regulation of B cell proliferation|negative regulation of T cell proliferation|positive regulation of amyloid precursor protein biosynthetic process|positive regulation of apoptotic process|leucine zipper domain binding|negative regulation of fibroblast proliferation|negative regulation of T cell receptor signaling pathway|actin filament bundle assembly|apoptotic signaling pathway|positive regulation of hydrogen peroxide-mediated programmed cell death|positive regulation of cellular senescence"]
["PC",7.86786646060028,10.0050038666029,10.5619746312411,10.9476104253691,9.17537695421498,11.0408054503141,11.4231690694938,11.1851821381527,12.1155326566146,15.2003183588164,13.732988080824,12.0416035392938,12.6366354180522,14.3491288723781,13.1636520007201,14.6472829319439,10.6821308885844,12.3651996861847,10.6984296874163,11.0866357122259,11.0174422713695,10.8101531868229,8.36833377875908,9.70232944185659,10.6757559782909,10.8502817340336,8.86956627481778,11.903885502839,5091,"pyruvate carboxylase","protein_coding","hsa00020,hsa00620","Citrate cycle (TCA cycle)|Pyruvate metabolism","GO:0004736,GO:0005515,GO:0005524,GO:0005737,GO:0005739,GO:0005759,GO:0005829,GO:0006090,GO:0006094,GO:0006629,GO:0006734,GO:0006739,GO:0009374,GO:0010629,GO:0019074,GO:0019076,GO:0042802,GO:0044794,GO:0046872","pyruvate carboxylase activity|protein binding|ATP binding|cytoplasm|mitochondrion|mitochondrial matrix|cytosol|pyruvate metabolic process|gluconeogenesis|lipid metabolic process|NADH metabolic process|NADP metabolic process|biotin binding|negative regulation of gene expression|viral RNA genome packaging|viral release from host cell|identical protein binding|positive regulation by host of viral process|metal ion binding","WP106,WP2453,WP534,WP357,WP5355,WP5031,WP3925","Alanine and aspartate metabolism|TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc)|Glycolysis and gluconeogenesis|Fatty acid biosynthesis|Metabolic Epileptic Disorders|Biotin metabolism, including IMDs|Amino acid metabolism","R-HSA-1430728,R-HSA-1643685,R-HSA-196780,R-HSA-196849,R-HSA-196854,R-HSA-3296482,R-HSA-3323169,R-HSA-3371599,R-HSA-5668914,R-HSA-70263,R-HSA-70326,R-HSA-71387","Metabolism|Disease|Biotin transport and metabolism|Metabolism of water-soluble vitamins and cofactors|Metabolism of vitamins and cofactors|Defects in vitamin and cofactor metabolism|Defects in biotin (Btn) metabolism|Defective HLCS causes multiple carboxylase deficiency|Diseases of metabolism|Gluconeogenesis|Glucose metabolism|Metabolism of carbohydrates"]
["PCDHA1",0.0433612041317583,0,0,0.00924131520499831,0.0376628830318282,9.04852897838976E-3,0,0.00472442906524358,0.00969233187739703,0,0,0,0,0.00918657767170557,0.00896126161848633,0.0137043360574514,0,0,0,0,0.00454739410525916,0,0,0.00470696769574166,0.00477658940375511,0,0,4.52939432662431E-3,56147,"protocadherin alpha 1","protein_coding",null,null,"GO:0005509,GO:0005576,GO:0005783,GO:0005886,GO:0007155,GO:0007156,GO:0007399","calcium ion binding|extracellular region|endoplasmic reticulum|plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|nervous system development"]
["PCDHB6",0.03337197800711,0.0714201477996449,0.0313308074220363,0.112019842155295,0.0733718072991221,0.0783449700310906,0.0778393852747863,0.0490866863881853,0.243365724043184,0.345521041414775,0.227537015928378,0.176268658792498,0.142814048330421,0.174988524545069,0.209491331847204,0.134477243794954,0.0802128384151612,0.0771947897568096,0.0308430937993477,0.112319206256512,0.0944945961705664,0.047581942625414,0.0247091167963878,0.0326035088302997,0.165428769507953,0.0554914178138211,0.0565135378411038,0.0941205617733075,56130,"protocadherin beta 6","protein_coding",null,null,"GO:0005509,GO:0005886,GO:0007155,GO:0007156,GO:0007268,GO:0007399,GO:0007416,GO:0009988,GO:0016020,GO:0016339,GO:0042802,GO:0045202","calcium ion binding|plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|chemical synaptic transmission|nervous system development|synapse assembly|cell-cell recognition|membrane|calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules|identical protein binding|synapse"]
["PCDHGA3",0.636239974396787,0.527708044476568,0.272380136447043,0.395403875031081,0.726153683492482,0.525766348163706,0.280182103012599,0.464177831885105,0.404461777895475,0.426495328543565,0.296780068918667,0.307252932972896,0.48888732802235,0.310567384128052,0.350286173329106,0.492253747773599,0.151703136489821,0.207219034950662,0.103492673406591,0.230045016515095,0.19216518141182,0.106439440008172,0.130646655689662,0.149181368529123,0.242220704356584,0.295016698002369,0.0689559066331595,0.157908746506095,56112,"protocadherin gamma subfamily A%2C 3","protein_coding",null,null,"GO:0005509,GO:0005886,GO:0007155,GO:0007156,GO:0007399,GO:0008333,GO:0060989","calcium ion binding|plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|nervous system development|endosome to lysosome transport|lipid tube assembly involved in organelle fusion"]
["PCMT1",39.5482188918445,30.3641275598955,31.3606712917839,32.1703592585521,32.1053067975106,28.9263116075406,30.6324107078331,32.5041230548302,31.6880771409183,22.0432421912394,25.8990051392041,28.9970221282905,28.7397211861613,22.5648294136205,29.0051561788014,24.0109214596899,48.2464402541971,39.3003382465653,52.6394859624684,43.1878313475587,45.9332632608101,42.7897597909669,57.3441102985872,51.2812933079805,47.6819628331707,44.1252537518268,58.1046397638237,44.9184071077351,5110,"protein-L-isoaspartate (D-aspartate) O-methyltransferase","protein_coding",null,null,"GO:0004719,GO:0005515,GO:0005737,GO:0005829,GO:0006479,GO:0030091,GO:0045296,GO:0070062,GO:1903561","protein-L-isoaspartate (D-aspartate) O-methyltransferase activity|protein binding|cytoplasm|cytosol|protein methylation|protein repair|cadherin binding|extracellular exosome|extracellular vesicle","WP5316","Primary ovarian insufficiency","R-HSA-392499,R-HSA-5676934","Metabolism of proteins|Protein repair"]
["PCSK7",11.8215290097882,9.79110729863132,7.3442610928226,10.1106621960031,11.5110320553405,9.52380072324479,6.13077242845694,9.66088079677381,12.7795455713549,15.9195197878536,10.4986255805505,13.3471345445246,9.82431685917928,9.93671160769729,6.88566561432985,9.24960804096132,12.1797307198885,10.7847670592159,8.72270518823555,11.6864332250215,11.3575592522172,11.6916947465719,9.42630872117575,10.2500689838678,12.9154191103383,12.3868804594361,8.22894222633256,10.8151080818807,9159,"proprotein convertase subtilisin/kexin type 7","protein_coding",null,null,"GO:0000139,GO:0004252,GO:0005515,GO:0005802,GO:0008233,GO:0016020,GO:0016485,GO:0016486","Golgi membrane|serine-type endopeptidase activity|protein binding|trans-Golgi network|peptidase activity|membrane|protein processing|peptide hormone processing"]
["PDCD6IP",25.536108110781,24.5697524520645,21.7579049349516,20.6947986895182,25.7241375671985,23.4878509605069,21.1681811721983,20.4687149875197,25.7452267084126,20.8820939579431,18.7702481210572,21.2716121768295,25.7473717975888,20.3471570467633,24.1086263364237,24.8241445992403,23.122239731724,21.678882799034,21.3067092710241,24.502857721532,23.7019290488288,21.2822739395152,26.1128400986601,25.6616014503148,22.9949249296242,19.5709366060843,22.7048308410286,20.3762129650866,10015,"programmed cell death 6 interacting protein","protein_coding","hsa03250,hsa04144","Viral life cycle - HIV-1|Endocytosis","GO:0000281,GO:0000915,GO:0001772,GO:0005515,GO:0005768,GO:0005815,GO:0005829,GO:0005923,GO:0005925,GO:0006915,GO:0006997,GO:0007080,GO:0010824,GO:0015031,GO:0016020,GO:0016236,GO:0031871,GO:0036258,GO:0039702,GO:0042470,GO:0042641,GO:0042803,GO:0045199,GO:0046755,GO:0048306,GO:0051260,GO:0061952,GO:0070062,GO:0070830,GO:0070971,GO:0090543,GO:0090559,GO:0090611,GO:0097734,GO:1901673,GO:1903543,GO:1903551,GO:1903553,GO:1903561","mitotic cytokinesis|actomyosin contractile ring assembly|immunological synapse|protein binding|endosome|microtubule organizing center|cytosol|bicellular tight junction|focal adhesion|apoptotic process|nucleus organization|mitotic metaphase chromosome alignment|regulation of centrosome duplication|protein transport|membrane|macroautophagy|proteinase activated receptor binding|multivesicular body assembly|viral budding via host ESCRT complex|melanosome|actomyosin|protein homodimerization activity|maintenance of epithelial cell apical/basal polarity|viral budding|calcium-dependent protein binding|protein homooligomerization|midbody abscission|extracellular exosome|bicellular tight junction assembly|endoplasmic reticulum exit site|Flemming body|regulation of membrane permeability|ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway|extracellular exosome biogenesis|regulation of mitotic spindle assembly|positive regulation of exosomal secretion|regulation of extracellular exosome assembly|positive regulation of extracellular exosome assembly|extracellular vesicle","WP4301","Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells","R-HSA-162587,R-HSA-162588,R-HSA-162599,R-HSA-162906,R-HSA-1643685,R-HSA-5210891,R-HSA-5213460,R-HSA-5218859,R-HSA-5339562,R-HSA-5357801,R-HSA-5663205,R-HSA-5675482,R-HSA-9824439,R-HSA-9824446","HIV Life Cycle|Budding and maturation of HIV virion|Late Phase of HIV Life Cycle|HIV Infection|Disease|Uptake and function of anthrax toxins|RIPK1-mediated regulated necrosis|Regulated Necrosis|Uptake and actions of bacterial toxins|Programmed Cell Death|Infectious disease|Regulation of necroptotic cell death|Bacterial Infection Pathways|Viral Infection Pathways"]
["PDE4D",1.60127674681586,1.67247918429287,1.40024257478965,1.17844996074917,1.4329502993609,1.2674251164003,1.21126239504216,1.1122299482262,1.37158390949852,0.800569773937924,0.922891661079274,1.08100389747839,1.61797498739649,1.05352774578941,1.69213068403184,1.6065548004317,1.51948462437653,1.44687986086362,1.77540707784751,1.98225308130377,1.68979317198862,1.88145081069409,2.76642216676402,1.97180029609361,1.44422309927717,1.5320669041811,2.0673798723781,1.33681361142601,5144,"phosphodiesterase 4D","protein_coding","hsa00230,hsa04024,hsa04928,hsa05032","Purine metabolism|cAMP signaling pathway|Parathyroid hormone synthesis, secretion and action|Morphine addiction","GO:0002027,GO:0004114,GO:0004115,GO:0005515,GO:0005634,GO:0005815,GO:0005829,GO:0005886,GO:0005891,GO:0006198,GO:0007165,GO:0010469,GO:0010880,GO:0016324,GO:0019899,GO:0019933,GO:0030552,GO:0031698,GO:0032729,GO:0032743,GO:0032754,GO:0033137,GO:0034704,GO:0043951,GO:0044325,GO:0045822,GO:0046872,GO:0048471,GO:0050852,GO:0051117,GO:0060314,GO:0061028,GO:0071875,GO:0086004,GO:0086024,GO:0097110,GO:1901363,GO:1901844,GO:1901898","regulation of heart rate|3',5'-cyclic-nucleotide phosphodiesterase activity|3',5'-cyclic-AMP phosphodiesterase activity|protein binding|nucleus|microtubule organizing center|cytosol|plasma membrane|voltage-gated calcium channel complex|cAMP catabolic process|signal transduction|regulation of signaling receptor activity|regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|apical plasma membrane|enzyme binding|cAMP-mediated signaling|cAMP binding|beta-2 adrenergic receptor binding|positive regulation of type II interferon production|positive regulation of interleukin-2 production|positive regulation of interleukin-5 production|negative regulation of peptidyl-serine phosphorylation|calcium channel complex|negative regulation of cAMP-mediated signaling|transmembrane transporter binding|negative regulation of heart contraction|metal ion binding|perinuclear region of cytoplasm|T cell receptor signaling pathway|ATPase binding|regulation of ryanodine-sensitive calcium-release channel activity|establishment of endothelial barrier|adrenergic receptor signaling pathway|regulation of cardiac muscle cell contraction|adenylate cyclase-activating adrenergic receptor signaling pathway involved in positive regulation of heart rate|scaffold protein binding|heterocyclic compound binding|regulation of cell communication by electrical coupling involved in cardiac conduction|negative regulation of relaxation of cardiac muscle","WP35,WP289,WP2032,WP4222,WP5294","G protein signaling pathways|Myometrial relaxation and contraction pathways|Thyroid stimulating hormone (TSH) signaling pathway|Phosphodiesterases in neuronal function|Sildenafil treatment","R-HSA-111885,R-HSA-162582,R-HSA-180024,R-HSA-372790,R-HSA-388396,R-HSA-418555,R-HSA-418594","Opioid Signalling|Signal Transduction|DARPP-32 events|Signaling by GPCR|GPCR downstream signalling|G alpha (s) signalling events|G alpha (i) signalling events"]
["PDHB",50.3707379578265,43.3171963974417,51.0347511702458,47.3306345388364,46.2662557648033,44.7811218793914,52.9866951484737,49.1653651479535,47.3195785421751,36.5229300134197,46.8661068192652,47.9777255811016,49.0758633266562,42.9745299351179,45.6467757216001,42.9764159371401,70.6305020262719,56.6524366161682,68.0616566825574,63.1098877152751,65.9956185162428,63.2495680863184,75.031979520555,74.724970594437,66.5199346020245,63.5487411703658,74.8624908813085,63.7668991959521,5162,"pyruvate dehydrogenase E1 subunit beta","protein_coding","hsa00010,hsa00020,hsa00620,hsa00785,hsa04066,hsa04922,hsa05230,hsa05415","Glycolysis / Gluconeogenesis|Citrate cycle (TCA cycle)|Pyruvate metabolism|Lipoic acid metabolism|HIF-1 signaling pathway|Glucagon signaling pathway|Central carbon metabolism in cancer|Diabetic cardiomyopathy","GO:0004739,GO:0005515,GO:0005634,GO:0005654,GO:0005739,GO:0005759,GO:0005967,GO:0006006,GO:0006086,GO:0006099,GO:0034604,GO:0045254","pyruvate dehydrogenase (acetyl-transferring) activity|protein binding|nucleus|nucleoplasm|mitochondrion|mitochondrial matrix|mitochondrial pyruvate dehydrogenase complex|glucose metabolic process|acetyl-CoA biosynthetic process from pyruvate|tricarboxylic acid cycle|pyruvate dehydrogenase (NAD+) activity|pyruvate dehydrogenase complex","WP4206,WP5220,WP4290,WP5094","Hereditary leiomyomatosis and renal cell carcinoma pathway|Metabolic reprogramming in pancreatic cancer|Metabolic reprogramming in colon cancer|Orexin receptor pathway","R-HSA-1428517,R-HSA-1430728,R-HSA-162582,R-HSA-204174,R-HSA-389661,R-HSA-5362517,R-HSA-70268,R-HSA-71291,R-HSA-71406,R-HSA-9006931","The citric acid (TCA) cycle and respiratory electron transport|Metabolism|Signal Transduction|Regulation of pyruvate dehydrogenase (PDH) complex|Glyoxylate metabolism and glycine degradation|Signaling by Retinoic Acid|Pyruvate metabolism|Metabolism of amino acids and derivatives|Pyruvate metabolism and Citric Acid (TCA) cycle|Signaling by Nuclear Receptors"]
["PDXP-DT",0.665243357990575,0.369108136597445,0.22119630581879,0.571548025345634,0.48753585477319,0.338377766191866,0.258610852259984,0.380529078334734,0.362453346582248,0.480535965244227,0.3519128917391,0.404362763133756,0.382220323179437,0.290687878048904,0.283558275737656,0.105125292533252,0.266496329994227,0.11541117179117,0.281798045429978,0.186582702012746,0.104648514216658,0.0395211456613657,0.273642352593415,0.297882084148504,0.480912915162131,0.197531514090844,0.402339862132809,0.286644291858193,101927051,"PDXP divergent transcript","non_coding"]
["PEAR1",14.0633852436969,16.9235622679387,12.7283020768255,13.6439713570408,16.4954797575549,15.7619010802477,11.993790175329,13.1550987297924,14.8270806845015,20.985647840454,13.5875051996535,15.187812359779,15.7675081520288,18.322018674819,13.1216364221138,16.4220261931497,13.40051253389,14.7839539348891,9.75598794455155,14.359832346039,13.7275200055583,13.224710247115,9.00539243162941,11.5993758206879,14.9416390910368,11.9724479719682,8.3902545494903,12.4508891537907,375033,"platelet endothelial aggregation receptor 1","protein_coding",null,null,"GO:0001891,GO:0005515,GO:0016020,GO:0038023,GO:0043491,GO:0043654,GO:0070527","phagocytic cup|protein binding|membrane|signaling receptor activity|phosphatidylinositol 3-kinase/protein kinase B signal transduction|recognition of apoptotic cell|platelet aggregation"]
["PEMT",9.78675999053102,11.9684989236771,12.4856537395426,11.7407665574545,8.89678411770114,12.8407554543139,14.0145899062566,12.4893016591829,12.2108668437931,16.3064859658658,16.4836074335666,13.0025969010388,11.22043276364,13.3942742910533,11.6862418414777,11.6719162754206,10.3601501796996,12.3051717425247,14.3083277589577,10.8867727476019,9.89705380242814,12.3171320929012,12.10235661594,10.7607355031358,9.12808954178705,13.414151473023,10.9058872454508,14.4902801876955,10400,"phosphatidylethanolamine N-methyltransferase","protein_coding","hsa00564","Glycerophospholipid metabolism","GO:0000773,GO:0001835,GO:0004608,GO:0005739,GO:0005783,GO:0005789,GO:0005829,GO:0006656,GO:0006686,GO:0031966,GO:0032259,GO:0043231,GO:0080101,GO:0120162","phosphatidyl-N-methylethanolamine N-methyltransferase activity|blastocyst hatching|phosphatidylethanolamine N-methyltransferase activity|mitochondrion|endoplasmic reticulum|endoplasmic reticulum membrane|cytosol|phosphatidylcholine biosynthetic process|sphingomyelin biosynthetic process|mitochondrial membrane|methylation|intracellular membrane-bounded organelle|phosphatidyl-N-dimethylethanolamine N-methyltransferase activity|positive regulation of cold-induced thermogenesis","WP2525,WP5381,WP4288,WP528,WP4673,WP4722,WP2533,WP3933","Trans-sulfuration, one-carbon metabolism and related pathways|Smith-Magenis and Potocki-Lupski syndrome copy number variation|MTHFR deficiency|Acetylcholine synthesis|Male infertility|Glycerolipids and glycerophospholipids|Glycerophospholipid biosynthetic pathway|Kennedy pathway from sphingolipids","R-HSA-1430728,R-HSA-1483191,R-HSA-1483206,R-HSA-1483257,R-HSA-556833","Metabolism|Synthesis of PC|Glycerophospholipid biosynthesis|Phospholipid metabolism|Metabolism of lipids"]
["PFDN1",31.7212721311317,31.8832564949755,35.1442359291791,33.8072190662851,30.7551591728589,32.5345667439661,36.834425865545,33.6104018479951,30.429342554621,31.4906843148872,35.0881408036308,34.0556667422762,32.1646992798216,31.6039097311989,34.7111022152984,30.0896046727745,46.6449015123887,43.2889229727145,55.6143639887754,41.0679512167966,46.6211329893394,44.5365528609862,55.1755962680175,52.3892338391336,44.9410511838749,50.7698254706041,61.2725897071247,51.7812565479797,5201,"prefoldin subunit 1","protein_coding",null,null,"GO:0001540,GO:0005515,GO:0005737,GO:0006457,GO:0016272,GO:0044183,GO:0051082,GO:0061077,GO:1905907","amyloid-beta binding|protein binding|cytoplasm|protein folding|prefoldin complex|protein folding chaperone|unfolded protein binding|chaperone-mediated protein folding|negative regulation of amyloid fibril formation","WP4918","Cellular proteostasis","R-HSA-389957,R-HSA-389958,R-HSA-390466,R-HSA-391251,R-HSA-392499","Prefoldin mediated transfer of substrate  to CCT/TriC|Cooperation of Prefoldin and TriC/CCT  in actin and tubulin folding|Chaperonin-mediated protein folding|Protein folding|Metabolism of proteins"]
["PGAP6",29.5358263162955,30.0604939324988,27.1136857680194,31.4916342705756,27.9458327821725,30.0024041777009,26.9516093765235,30.5384139641281,24.3601061248885,39.0857041486005,29.3759832503203,26.2720065743591,24.5181676969423,27.6229598016984,22.8644398387504,25.5312586672248,26.5887612768939,26.3350613347178,27.0978530306938,27.1827598291563,29.0608203664438,28.2872168694557,21.4757495391963,24.0687037361639,26.4106897858044,29.3378211917522,23.9444020615442,30.1922270314121,58986,"post-glycosylphosphatidylinositol attachment to proteins 6","protein_coding",null,null,"GO:0003674,GO:0004623,GO:0005515,GO:0005765,GO:0005886,GO:0006629,GO:0008150,GO:0070062","molecular_function|phospholipase A2 activity|protein binding|lysosomal membrane|plasma membrane|lipid metabolic process|biological_process|extracellular exosome"]
["PGRMC1",78.0568212320158,76.0188983382991,74.0502466226365,73.4851654957072,79.007418111596,76.0879677736414,71.2870654954985,77.9631117595793,88.2260886550235,69.638075218735,82.3933494581353,82.5441081902332,98.3657409680624,88.0401098044549,93.8324571120134,96.1405487646802,72.2331636495382,68.1746915517317,81.0650314669563,78.0960957577412,71.5211192336146,71.5504156022151,84.7354515800069,78.1234642108984,69.6927018619735,72.0824277972888,78.9075761047688,72.2900012453443,10857,"progesterone receptor membrane component 1","protein_coding","hsa04080","Neuroactive ligand-receptor interaction","GO:0001540,GO:0005496,GO:0005515,GO:0005576,GO:0005741,GO:0005783,GO:0005886,GO:0006783,GO:0012505,GO:0016020,GO:0020037,GO:0030868,GO:0035579,GO:0042803,GO:0043005,GO:0043025,GO:0044297,GO:0045202,GO:0046872,GO:1903078","amyloid-beta binding|steroid binding|protein binding|extracellular region|mitochondrial outer membrane|endoplasmic reticulum|plasma membrane|heme biosynthetic process|endomembrane system|membrane|heme binding|smooth endoplasmic reticulum membrane|specific granule membrane|protein homodimerization activity|neuron projection|neuronal cell body|cell body|synapse|metal ion binding|positive regulation of protein localization to plasma membrane","WP5316","Primary ovarian insufficiency","R-HSA-168249,R-HSA-168256,R-HSA-6798695","Innate Immune System|Immune System|Neutrophil degranulation"]
["PHACTR3",0,0,0,0,0,0,0,0,0,0.0162721970193952,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,116154,"phosphatase and actin regulator 3","protein_coding",null,null,"GO:0003779,GO:0004864,GO:0005515,GO:0005654,GO:0016363,GO:0030036","actin binding|protein phosphatase inhibitor activity|protein binding|nucleoplasm|nuclear matrix|actin cytoskeleton organization"]
["PHIP",4.62131963194746,3.94507785306784,2.71844835600075,2.71728289830394,5.3502399848022,3.54398167721524,2.47743478479056,2.8132004784959,4.93699006917161,2.94514885105288,2.7691121944733,3.4300185354983,6.12908032464731,2.94501588068908,4.37639450237159,4.99743012876315,2.67912799432382,2.39312955460807,3.0173278802169,4.23651718432416,3.62087334235176,3.27869654623968,6.52065050783249,4.37367624871701,3.20144589726444,2.59915033267459,4.29980189102365,2.3437289472499,55023,"pleckstrin homology domain interacting protein","protein_coding",null,null,"GO:0001932,GO:0005158,GO:0005515,GO:0005634,GO:0006357,GO:0007010,GO:0008284,GO:0008286,GO:0008360,GO:0022604,GO:0043066,GO:0043568,GO:0045840,GO:0045893,GO:0045944,GO:0070577,GO:2001237","regulation of protein phosphorylation|insulin receptor binding|protein binding|nucleus|regulation of transcription by RNA polymerase II|cytoskeleton organization|positive regulation of cell population proliferation|insulin receptor signaling pathway|regulation of cell shape|regulation of cell morphogenesis|negative regulation of apoptotic process|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of mitotic nuclear division|positive regulation of DNA-templated transcription|positive regulation of transcription by RNA polymerase II|lysine-acetylated histone binding|negative regulation of extrinsic apoptotic signaling pathway",null,null,"R-HSA-162582,R-HSA-194315,R-HSA-9012999,R-HSA-9013418,R-HSA-9706574,R-HSA-9716542","Signal Transduction|Signaling by Rho GTPases|RHO GTPase cycle|RHOBTB2 GTPase cycle|RHOBTB GTPase Cycle|Signaling by Rho GTPases, Miro GTPases and RHOBTB3"]
["PI4KA",14.2344217748558,15.4190280142631,14.7248767093774,14.1339491184552,15.1070957816957,15.7871212297241,14.1236824716423,13.8118280896131,13.6579238250655,17.1454798937007,13.0873632212132,13.8941080954695,13.1631735406091,12.6156174160117,13.8371655667408,14.1855557984456,13.3191261175011,14.4066033710239,11.2457568027783,14.0168181292698,13.4796830664323,13.4108363341631,11.4731765311122,12.0680312645574,12.8775555403755,12.4426427967157,10.9723668945937,12.7984106918976,5297,"phosphatidylinositol 4-kinase alpha","protein_coding","hsa00562,hsa04070","Inositol phosphate metabolism|Phosphatidylinositol signaling system","GO:0004430,GO:0005515,GO:0005524,GO:0005737,GO:0005829,GO:0005886,GO:0005925,GO:0006661,GO:0007165,GO:0016020,GO:0016301,GO:0016310,GO:0030660,GO:0044788,GO:0045296,GO:0046854,GO:0048015,GO:0070062,GO:0140754","1-phosphatidylinositol 4-kinase activity|protein binding|ATP binding|cytoplasm|cytosol|plasma membrane|focal adhesion|phosphatidylinositol biosynthetic process|signal transduction|membrane|kinase activity|phosphorylation|Golgi-associated vesicle membrane|modulation by host of viral process|cadherin binding|phosphatidylinositol phosphate biosynthetic process|phosphatidylinositol-mediated signaling|extracellular exosome|reorganization of cellular membranes to establish viral sites of replication","WP4657,WP2858","22q11.2 copy number variation syndrome|Ectoderm differentiation","R-HSA-1430728,R-HSA-1483248,R-HSA-1483255,R-HSA-1483257,R-HSA-1660514,R-HSA-556833","Metabolism|Synthesis of PIPs at the ER membrane|PI Metabolism|Phospholipid metabolism|Synthesis of PIPs at the Golgi membrane|Metabolism of lipids"]
["PIGL",1.29728661716065,1.03409446710177,1.08957020585329,1.19299914309929,1.18618511575158,1.10547825255684,0.986331808262261,1.07263184997802,1.33508484151345,0.995708277468511,0.987936414084673,1.2078769266543,1.04024742168772,1.3162900815478,1.10101953842496,1.26480696509449,1.1190092866617,1.07690599567962,0.973978578397836,1.0679098756926,1.08909610621651,0.919291608325842,0.99098445573458,1.15663700500735,1.18035770430552,0.887258547353488,1.03914154090955,0.928024314265626,9487,"phosphatidylinositol glycan anchor biosynthesis class L","protein_coding","hsa00563","Glycosylphosphatidylinositol (GPI)-anchor biosynthesis","GO:0000225,GO:0005789,GO:0006506,GO:0016254","N-acetylglucosaminylphosphatidylinositol deacetylase activity|endoplasmic reticulum membrane|GPI anchor biosynthetic process|preassembly of GPI anchor in ER membrane",null,null,"R-HSA-162710,R-HSA-163125,R-HSA-392499,R-HSA-597592","Synthesis of glycosylphosphatidylinositol (GPI)|Post-translational modification: synthesis of GPI-anchored proteins|Metabolism of proteins|Post-translational protein modification"]
["PIK3C2B",0.232683423456633,0.163716564413375,0.197504119649981,0.171188889678968,0.124585450256047,0.182583522388526,0.246830098939284,0.168782281362426,0.259697076101274,0.322341313251357,0.332734371973307,0.291821862569914,0.2485609527463,0.34642750599172,0.447610090579998,0.341506480126238,0.156291258447306,0.150410720715583,0.212105078536415,0.229883542425627,0.120338985545347,0.127250892321034,0.160482163683953,0.183728694714768,0.214887218227819,0.151432263177128,0.154221558442377,0.230735605631388,5287,"phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta","protein_coding","hsa00562,hsa04070,hsa05132","Inositol phosphate metabolism|Phosphatidylinositol signaling system|Salmonella infection","GO:0005515,GO:0005524,GO:0005654,GO:0005737,GO:0005783,GO:0005829,GO:0005886,GO:0005942,GO:0008150,GO:0009267,GO:0016303,GO:0016310,GO:0016477,GO:0030139,GO:0035005,GO:0035091,GO:0036092,GO:0043231,GO:0043491,GO:0048015,GO:1905037","protein binding|ATP binding|nucleoplasm|cytoplasm|endoplasmic reticulum|cytosol|plasma membrane|phosphatidylinositol 3-kinase complex|biological_process|cellular response to starvation|1-phosphatidylinositol-3-kinase activity|phosphorylation|cell migration|endocytic vesicle|1-phosphatidylinositol-4-phosphate 3-kinase activity|phosphatidylinositol binding|phosphatidylinositol-3-phosphate biosynthetic process|intracellular membrane-bounded organelle|phosphatidylinositol 3-kinase/protein kinase B signal transduction|phosphatidylinositol-mediated signaling|autophagosome organization","WP2261,WP4787,WP51,WP3932,WP26,WP710,WP437,WP4971","Glioblastoma signaling pathways|Osteoblast differentiation and related diseases|Regulation of actin cytoskeleton|Focal adhesion: PI3K-Akt-mTOR-signaling pathway|S1P receptor signal transduction|DNA damage response (only ATM dependent)|EGF/EGFR signaling pathway|Phosphoinositides metabolism","R-HSA-1430728,R-HSA-1483255,R-HSA-1483257,R-HSA-1660499,R-HSA-556833","Metabolism|PI Metabolism|Phospholipid metabolism|Synthesis of PIPs at the plasma membrane|Metabolism of lipids"]
["PIN1-DT",0,0.0610472215716012,0.0903837846255353,0.0307768801023604,0.0313577128814105,0.0904044993465906,0.0598807271006749,0.0314680721667117,0,0.0927224655158752,0.0301794785905004,0.0322859431155647,0.122072007977669,0.0611891691347532,0,0.0304268889846987,0.0308532953475459,0.0296924244886014,0.118635757221062,0.0925773865854063,0,0.0610068478661558,0.538570499315552,0,0,0.182951807098424,0.186321674249598,0.211183010478858,100996288,null,"non_coding"]
["PITPNB",34.5540436348816,33.9208714212824,37.6752295461694,32.3116668916457,33.0372107238725,31.4151378897041,33.9121134721562,34.5639141440921,40.8331462187173,30.2974876022118,33.7691883226586,36.1687685908188,39.4101776414536,34.7015186313363,39.2796904750646,38.3940352077354,38.6148456159549,37.4202833668024,37.995838138983,41.3396096507614,37.7727021938215,40.0669079563902,43.2837183830117,39.1229902672862,38.9718870995887,38.4359581177839,37.891255235342,37.2334339755758,23760,"phosphatidylinositol transfer protein beta","protein_coding",null,null,"GO:0000139,GO:0005515,GO:0005737,GO:0005789,GO:0005794,GO:0006629,GO:0006890,GO:0006997,GO:0008525,GO:0008526,GO:0015914,GO:0031210,GO:0035091,GO:0120009,GO:0120019,GO:0140338","Golgi membrane|protein binding|cytoplasm|endoplasmic reticulum membrane|Golgi apparatus|lipid metabolic process|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|nucleus organization|phosphatidylcholine transporter activity|phosphatidylinositol transfer activity|phospholipid transport|phosphatidylcholine binding|phosphatidylinositol binding|intermembrane lipid transfer|phosphatidylcholine transfer activity|sphingomyelin transfer activity",null,null,"R-HSA-1430728,R-HSA-1483196,R-HSA-1483206,R-HSA-1483255,R-HSA-1483257,R-HSA-556833","Metabolism|PI and PC transport between ER and Golgi membranes|Glycerophospholipid biosynthesis|PI Metabolism|Phospholipid metabolism|Metabolism of lipids"]
["PITX1-AS1",1.93476060962632,0.951155097389787,0.908211255188846,0.886076306172797,1.24267581531654,0.99007508155379,0.892415997435865,1.51351276130861,1.27918262740368,0.628119927688187,0.71554570206509,1.45442966325439,0.857949636714023,1.00518014135074,0.798573072919163,0.875999948994954,0.449363317723128,0.191085118886322,0.663020804469325,0.324020853048922,0.0615548468199798,0.578581073311284,0.922825732223803,0.76457857522281,1.03451681473586,0.423444908364902,0.86248904047798,0.3372115812485,100996485,"PITX1 antisense RNA 1","non_coding"]
["PKNOX2",0.025975635013484,0,0,0.00622803644567159,0.0190367228285123,0.00609811125440746,0,0.0191037200337541,0.0391919514724426,0.0250178659064756,0.0671786032705911,0.0392004705618998,0.0123512992894775,0.123822939227156,0.0543536893277378,0.0800437551705395,0.0312174995084781,0.0300429252835764,0.0120036179313048,0.0187340411302677,0.0367757215402433,0.0123453992309253,0.0128218351191084,0.00634437105701628,0.0257528477128497,0.0123407627047841,6.28403623101512E-3,0.00610502559803976,63876,"PBX/knotted 1 homeobox 2","protein_coding",null,null,"GO:0000978,GO:0000981,GO:0003785,GO:0005515,GO:0005654,GO:0005737,GO:0006357,GO:0015629,GO:0015630,GO:0045171,GO:0051015,GO:1990837","RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|actin monomer binding|protein binding|nucleoplasm|cytoplasm|regulation of transcription by RNA polymerase II|actin cytoskeleton|microtubule cytoskeleton|intercellular bridge|actin filament binding|sequence-specific double-stranded DNA binding"]
["PLAA",7.41350047915441,6.74667414496366,6.13883761279941,6.12155853293793,7.36263986304733,6.24190422797825,6.06425830984859,6.22082082061934,7.71396345610429,5.15075157837585,6.31223793169984,6.43478295656527,6.967811385482,5.87887843792983,6.66093815112312,6.57338110557143,6.18255431590824,5.75761152637767,6.26339624268308,7.03736856742398,6.53948145064739,6.18241926231096,7.25463241544374,7.05664060109256,6.69735383676391,5.74806657547147,6.51183027305103,5.83781083424932,9373,"phospholipase A2 activating protein","protein_coding","hsa04141","Protein processing in endoplasmic reticulum","GO:0005515,GO:0005634,GO:0005737,GO:0006644,GO:0006693,GO:0006954,GO:0007165,GO:0007399,GO:0010992,GO:0016005,GO:0016236,GO:0032430,GO:0043130,GO:0043161,GO:0043162,GO:0045202,GO:0070062,GO:0071222,GO:1900045,GO:1903423,GO:1903861,GO:2001224","protein binding|nucleus|cytoplasm|phospholipid metabolic process|prostaglandin metabolic process|inflammatory response|signal transduction|nervous system development|ubiquitin recycling|phospholipase A2 activator activity|macroautophagy|positive regulation of phospholipase A2 activity|ubiquitin binding|proteasome-mediated ubiquitin-dependent protein catabolic process|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|synapse|extracellular exosome|cellular response to lipopolysaccharide|negative regulation of protein K63-linked ubiquitination|positive regulation of synaptic vesicle recycling|positive regulation of dendrite extension|positive regulation of neuron migration"]
["PLCH2",0.05433351521339,0.045220164127112,0.0223169838581568,0.0423385652201784,0.0232279354677115,0.0510219396665061,0.0316829243918914,0.04328941144627,0.040989113268357,0.0392476044511641,0.0383231474165084,0.0888290498417653,0.0322941820046744,0.0259001774115357,0.0347392823324352,0.0289779895092368,0.0685628785501021,0.0439887770201502,0.0533547056285201,0.055513776788427,0.032051738497008,0.0677853865179509,0.0335244630759759,0.0530823567803972,0.0235670350211727,0.0419466224387922,0.0328609654761196,0.0542722778252547,9651,"phospholipase C eta 2","protein_coding","hsa00562","Inositol phosphate metabolism","GO:0004435,GO:0005509,GO:0005575,GO:0005737,GO:0005886,GO:0007200,GO:0016042,GO:0046488,GO:0048015,GO:0051209","phosphatidylinositol phospholipase C activity|calcium ion binding|cellular_component|cytoplasm|plasma membrane|phospholipase C-activating G protein-coupled receptor signaling pathway|lipid catabolic process|phosphatidylinositol metabolic process|phosphatidylinositol-mediated signaling|release of sequestered calcium ion into cytosol","WP4971,WP5345","Phosphoinositides metabolism|1p36 copy number variation syndrome","R-HSA-1430728,R-HSA-1483249,R-HSA-1855204","Metabolism|Inositol phosphate metabolism|Synthesis of IP3 and IP4 in the cytosol"]
["PLEKHB1",0.0347934368960866,0.0496414967281172,0.0408316548808484,0,0.0509980228855466,0.0735138232828036,0.0486929436249437,0.102355007241192,0.043746851285928,0.0167552696640497,0.0327212158967671,0.0175025441865597,0.0413603124803332,0.116099488387334,0.129430806725862,0.0577315609002995,0.066903563967573,0.0402414271868751,0.0562744637350635,0.0418226335009902,0.065679690271507,0,0.00858719547909315,0.0339922352470791,0.0344950212507387,0,0.00841724246367983,0.0490647846223873,58473,"pleckstrin homology domain containing B1","protein_coding",null,null,"GO:0005515,GO:0005737,GO:0007602,GO:0016020,GO:0045595","protein binding|cytoplasm|phototransduction|membrane|regulation of cell differentiation"]
["PLEKHS1",4.68152400751009E-3,4.45290605419807E-3,0,4.48985399200812E-3,0,0.00439618961740975,0,0.00459068784648104,0.00470897853890555,0,0,0,0,0,0,0,0,0,0,0,0,0.0044499611156279,0,0,0,0.0177931594260364,0,0,79949,"pleckstrin homology domain containing S1","protein_coding"]
["PLIN5",0,0,0,0,0,0,0,0,0.0109774487558778,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.0105607426700177,0,440503,"perilipin 5","protein_coding","hsa03320","PPAR signaling pathway","GO:0005515,GO:0005737,GO:0005739,GO:0005811,GO:0005829,GO:0010867,GO:0010884,GO:0010890,GO:0010897,GO:0019915,GO:0031999,GO:0032000,GO:0034389,GO:0035359,GO:0035473,GO:0042802,GO:0043231,GO:0051646,GO:0060192,GO:0060193,GO:2000378","protein binding|cytoplasm|mitochondrion|lipid droplet|cytosol|positive regulation of triglyceride biosynthetic process|positive regulation of lipid storage|positive regulation of sequestering of triglyceride|negative regulation of triglyceride catabolic process|lipid storage|negative regulation of fatty acid beta-oxidation|positive regulation of fatty acid beta-oxidation|lipid droplet organization|negative regulation of peroxisome proliferator activated receptor signaling pathway|lipase binding|identical protein binding|intracellular membrane-bounded organelle|mitochondrion localization|negative regulation of lipase activity|positive regulation of lipase activity|negative regulation of reactive oxygen species metabolic process"]
["PLTP",27.0632374297254,32.4856048646973,32.730143903504,35.0773954183012,28.5758246656879,34.7853183292301,34.4485056352865,38.5412827105067,27.8813033949288,37.6227731046052,36.1704420824111,29.8793184724094,28.9683236003385,35.4052983015342,28.6024458756168,33.5749772306192,15.5114750962173,19.1611183181231,18.0020194183186,17.6241615355642,15.8969337736112,18.3492854678721,11.2918211241696,13.3441833385041,15.4116479323471,17.6814069053832,12.5570637037694,19.7579261218235,5360,"phospholipid transfer protein","protein_coding","hsa03320,hsa04979","PPAR signaling pathway|Cholesterol metabolism","GO:0005576,GO:0005615,GO:0005634,GO:0006629,GO:0006869,GO:0008035,GO:0008429,GO:0008525,GO:0008526,GO:0010189,GO:0010875,GO:0015914,GO:0015918,GO:0019992,GO:0030169,GO:0030317,GO:0031210,GO:0034189,GO:0034364,GO:0034375,GO:0035627,GO:0046836,GO:0070300,GO:0097001,GO:0120009,GO:0120014,GO:0120017,GO:0120019,GO:0120020,GO:0140337,GO:0140338,GO:0140339,GO:0140340,GO:1901611,GO:1904121,GO:1990050","extracellular region|extracellular space|nucleus|lipid metabolic process|lipid transport|high-density lipoprotein particle binding|phosphatidylethanolamine binding|phosphatidylcholine transporter activity|phosphatidylinositol transfer activity|vitamin E biosynthetic process|positive regulation of cholesterol efflux|phospholipid transport|sterol transport|diacylglycerol binding|low-density lipoprotein particle binding|flagellated sperm motility|phosphatidylcholine binding|very-low-density lipoprotein particle binding|high-density lipoprotein particle|high-density lipoprotein particle remodeling|ceramide transport|glycolipid transport|phosphatidic acid binding|ceramide binding|intermembrane lipid transfer|phospholipid transfer activity|ceramide transfer activity|phosphatidylcholine transfer activity|cholesterol transfer activity|diacylglyceride transfer activity|sphingomyelin transfer activity|phosphatidylglycerol transfer activity|cerebroside transfer activity|phosphatidylglycerol binding|phosphatidylethanolamine transfer activity|phosphatidic acid transfer activity","WP5112,WP5323,WP2878,WP5109,WP430,WP5111,WP2882,WP5110,WP5304,WP3942,WP5108","Familial hyperlipidemia type 5|Fatty Acids and Lipoproteins Transport in Hepatocytes|PPAR-alpha pathway|Familial hyperlipidemia type 2|Statin inhibition of cholesterol production|Familial hyperlipidemia type 4|Nuclear receptors meta-pathway|Familial hyperlipidemia type 3|Cholesterol metabolism|PPAR signaling pathway|Familial  hyperlipidemia type 1","R-HSA-162582,R-HSA-174824,R-HSA-382551,R-HSA-8963899,R-HSA-8964058,R-HSA-9006931,R-HSA-9024446,R-HSA-9029569","Signal Transduction|Plasma lipoprotein assembly, remodeling, and clearance|Transport of small molecules|Plasma lipoprotein remodeling|HDL remodeling|Signaling by Nuclear Receptors|NR1H2 and NR1H3-mediated signaling|NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux"]
["PLXNB2",52.7933096213696,57.1739186144861,47.7011027956931,54.5784081006552,56.0227615550629,55.8549675746408,44.3755099479821,50.6885888811014,48.8903382544932,70.3719997306948,48.9953484554081,47.1980859394107,46.8082250084771,48.4134449581884,39.0711237645468,46.6915440459417,41.6018260372144,46.152961327842,36.5094047809006,45.5667902059722,45.8302659662714,44.7673535433724,29.6070811547711,35.2452716083886,44.2671870257716,43.6739647811672,28.3551991985264,41.9632295551312,23654,"plexin B2","protein_coding","hsa04360","Axon guidance","GO:0001843,GO:0001932,GO:0002116,GO:0005515,GO:0005886,GO:0007156,GO:0007162,GO:0007405,GO:0007420,GO:0008360,GO:0009986,GO:0010976,GO:0017154,GO:0030334,GO:0043087,GO:0045727,GO:0050772,GO:0070062,GO:0071526,GO:1902287,GO:1904861,GO:2001222","neural tube closure|regulation of protein phosphorylation|semaphorin receptor complex|protein binding|plasma membrane|homophilic cell adhesion via plasma membrane adhesion molecules|negative regulation of cell adhesion|neuroblast proliferation|brain development|regulation of cell shape|cell surface|positive regulation of neuron projection development|semaphorin receptor activity|regulation of cell migration|regulation of GTPase activity|positive regulation of translation|positive regulation of axonogenesis|extracellular exosome|semaphorin-plexin signaling pathway|semaphorin-plexin signaling pathway involved in axon guidance|excitatory synapse assembly|regulation of neuron migration","WP5221","2q11.2 copy number variation syndrome"]
["PNKP",12.3802374997217,15.1528302833357,16.9447404891269,18.9675191757354,14.1821642175613,14.2871489550856,14.4419445118369,15.239927359213,13.001078968472,17.8181403403817,15.9192826755714,15.6516880559545,11.8327338062236,15.1732171920285,11.6583761693015,11.428276223161,13.1455357508504,17.8525058987618,17.1415304671056,14.9599922447543,15.5360498035839,16.3269973093445,14.5741822141217,12.9014966207441,14.4200846590902,18.643962317829,14.3158767621008,19.5298534474036,11284,"polynucleotide kinase 3'-phosphatase","protein_coding","hsa03410","Base excision repair","GO:0003684,GO:0003690,GO:0004519,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005730,GO:0006261,GO:0006281,GO:0006287,GO:0006289,GO:0006303,GO:0006979,GO:0009314,GO:0010836,GO:0016020,GO:0016310,GO:0017076,GO:0032212,GO:0035861,GO:0046403,GO:0046404,GO:0051103,GO:0051973,GO:1904355,GO:2001034","damaged DNA binding|double-stranded DNA binding|endonuclease activity|protein binding|ATP binding|nucleus|nucleoplasm|nucleolus|DNA-templated DNA replication|DNA repair|base-excision repair, gap-filling|nucleotide-excision repair|double-strand break repair via nonhomologous end joining|response to oxidative stress|response to radiation|negative regulation of protein ADP-ribosylation|membrane|phosphorylation|purine nucleotide binding|positive regulation of telomere maintenance via telomerase|site of double-strand break|polynucleotide 3'-phosphatase activity|ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity|DNA ligation involved in DNA repair|positive regulation of telomerase activity|positive regulation of telomere capping|positive regulation of double-strand break repair via nonhomologous end joining","WP4946,WP4752","DNA repair pathways, full network|Base excision repair","R-HSA-5649702,R-HSA-73884,R-HSA-73894,R-HSA-73933","APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway|Base Excision Repair|DNA Repair|Resolution of Abasic Sites (AP sites)"]
["POFUT2",14.7460162149484,14.0668661676755,12.986131696606,15.4592367082846,17.4340868869746,16.4262119082566,13.3918559011094,15.8111144283861,20.1504379683928,21.7550537302316,18.164896389541,19.7986067782795,20.6755400945351,21.0056748355566,16.7616986804853,20.7045420507594,19.3708751216104,20.0675254834464,15.998770965818,18.9512515968549,18.4113890073051,19.5468799244,12.0116437490649,14.7944280574263,19.1353783206098,18.6848544203822,13.2138246650993,18.0461392554032,23275,"protein O-fucosyltransferase 2","protein_coding","hsa00514","Other types of O-glycan biosynthesis","GO:0001707,GO:0005789,GO:0005794,GO:0006004,GO:0010468,GO:0010717,GO:0036066,GO:0046922,GO:0051046,GO:1903334","mesoderm formation|endoplasmic reticulum membrane|Golgi apparatus|fucose metabolic process|regulation of gene expression|regulation of epithelial to mesenchymal transition|protein O-linked fucosylation|peptide-O-fucosyltransferase activity|regulation of secretion|positive regulation of protein folding",null,null,"R-HSA-392499,R-HSA-5173105,R-HSA-5173214,R-HSA-597592","Metabolism of proteins|O-linked glycosylation|O-glycosylation of TSR domain-containing proteins|Post-translational protein modification"]
["POLQ",1.92082657380286,1.46981799659203,0.45372515383562,1.31373732811035,1.46787183559984,0.890314493964825,0.35038123291522,0.688222585516572,1.18588287056617,0.791587475387328,0.413972703927248,0.864055456042451,0.79039429625829,0.258256445268982,0.271961549718279,0.256840885434387,1.68694276720395,1.27314280541053,0.645810956575088,1.38829078524558,1.62702925780495,1.38691826803634,1.02411205117416,1.46157877689047,1.97454453134228,1.18165515695865,0.851926440213991,1.0099742467574,10721,"DNA polymerase theta","protein_coding",null,null,"GO:0003682,GO:0003684,GO:0003887,GO:0005515,GO:0005524,GO:0005654,GO:0005694,GO:0005794,GO:0005829,GO:0006261,GO:0006281,GO:0006284,GO:0006302,GO:0006974,GO:0016446,GO:0017116,GO:0032508,GO:0051260,GO:0051575,GO:0071897,GO:0097681,GO:2000042","chromatin binding|damaged DNA binding|DNA-directed DNA polymerase activity|protein binding|ATP binding|nucleoplasm|chromosome|Golgi apparatus|cytosol|DNA-templated DNA replication|DNA repair|base-excision repair|double-strand break repair|DNA damage response|somatic hypermutation of immunoglobulin genes|single-stranded DNA helicase activity|DNA duplex unwinding|protein homooligomerization|5'-deoxyribose-5-phosphate lyase activity|DNA biosynthetic process|double-strand break repair via alternative nonhomologous end joining|negative regulation of double-strand break repair via homologous recombination",null,null,"R-HSA-5685939,R-HSA-5693532,R-HSA-5693538,R-HSA-73894","HDR through MMEJ (alt-NHEJ)|DNA Double-Strand Break Repair|Homology Directed Repair|DNA Repair"]
["POLR3D",6.74915733775952,6.66943183796489,6.58771767551784,6.31295180090621,6.53081961757293,6.92129798970562,6.56084488233481,5.95935462629413,8.05908495225841,8.08645550083728,7.37813594656664,7.1154927106267,7.51854674322733,7.0798712563337,6.84515020677127,7.65416447187795,6.77546692058739,6.28215134007711,6.22370830563943,6.40269091931753,6.87085597774943,5.85830375686249,6.25894060739985,6.5542584509355,6.50095071079175,6.15370883396275,5.67554815077394,6.68218506170361,661,"RNA polymerase III subunit D","protein_coding","hsa03020,hsa04623","RNA polymerase|Cytosolic DNA-sensing pathway","GO:0003677,GO:0003682,GO:0005654,GO:0005666,GO:0005829,GO:0032728,GO:0042797,GO:0045087,GO:0045089,GO:0051607","DNA binding|chromatin binding|nucleoplasm|RNA polymerase III complex|cytosol|positive regulation of interferon-beta production|tRNA transcription by RNA polymerase III|innate immune response|positive regulation of innate immune response|defense response to virus","WP405,WP4655,WP4022","Eukaryotic transcription initiation|Cytosolic DNA-sensing pathway|Pyrimidine metabolism","R-HSA-168249,R-HSA-168256,R-HSA-1834949,R-HSA-73780,R-HSA-73980,R-HSA-74158,R-HSA-74158,R-HSA-74160,R-HSA-74160,R-HSA-749476,R-HSA-76046,R-HSA-76046,R-HSA-76061,R-HSA-76061,R-HSA-76066,R-HSA-76066,R-HSA-76071,R-HSA-76071","Innate Immune System|Immune System|Cytosolic sensors of pathogen-associated DNA |RNA Polymerase III Chain Elongation|RNA Polymerase III Transcription Termination|RNA Polymerase III Transcription|RNA Polymerase III Transcription|Gene expression (Transcription)|Gene expression (Transcription)|RNA Polymerase III Abortive And Retractive Initiation|RNA Polymerase III Transcription Initiation|RNA Polymerase III Transcription Initiation|RNA Polymerase III Transcription Initiation From Type 1 Promoter|RNA Polymerase III Transcription Initiation From Type 1 Promoter|RNA Polymerase III Transcription Initiation From Type 2 Promoter|RNA Polymerase III Transcription Initiation From Type 2 Promoter|RNA Polymerase III Transcription Initiation From Type 3 Promoter|RNA Polymerase III Transcription Initiation From Type 3 Promoter"]
["POM121C",10.5674612307924,11.327500816722,9.3603524013082,10.0158364951489,11.0533933621591,10.246973251318,7.96463681613817,8.08268723919343,9.76521434741596,12.1735573099656,9.92080272520585,10.5531615530221,9.37230884498741,8.88332822604694,8.2637968666272,8.97839565124761,7.93361436732942,8.70640390254488,7.2273380511253,8.93363101912283,8.13974631421889,8.13188943331319,7.10311089563411,6.8722731205897,8.2903583159192,7.73592710158125,6.05553380704166,7.18749335817598,100101267,"POM121 transmembrane nucleoporin C","protein_coding","hsa03013,hsa05014","Nucleocytoplasmic transport|Amyotrophic lateral sclerosis","GO:0005515,GO:0005635,GO:0005643,GO:0005654,GO:0005789,GO:0006405,GO:0006606,GO:0008139,GO:0017056,GO:0031965,GO:0051028","protein binding|nuclear envelope|nuclear pore|nucleoplasm|endoplasmic reticulum membrane|RNA export from nucleus|protein import into nucleus|nuclear localization sequence binding|structural constituent of nuclear pore|nuclear membrane|mRNA transport"]
["POU3F2",0,0,0,0,0,0,0,0.00541109122211624,0,0,0,0,0,0,0,0,0,0,0,0.00530638039793526,0,0,0,0,0,0.00524324523925884,0,0,5454,"POU class 3 homeobox 2","protein_coding",null,null,"GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0003677,GO:0003700,GO:0005515,GO:0005654,GO:0005667,GO:0006357,GO:0007399,GO:0008284,GO:0008544,GO:0010629,GO:0021799,GO:0021869,GO:0021897,GO:0021979,GO:0021985,GO:0022011,GO:0030182,GO:0040018,GO:0042802,GO:0045595,GO:0045944,GO:0048663,GO:0048665,GO:0048666,GO:0050770,GO:0061101,GO:0071310,GO:1990837","chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA binding|DNA-binding transcription factor activity|protein binding|nucleoplasm|transcription regulator complex|regulation of transcription by RNA polymerase II|nervous system development|positive regulation of cell population proliferation|epidermis development|negative regulation of gene expression|cerebral cortex radially oriented cell migration|forebrain ventricular zone progenitor cell division|forebrain astrocyte development|hypothalamus cell differentiation|neurohypophysis development|myelination in peripheral nervous system|neuron differentiation|positive regulation of multicellular organism growth|identical protein binding|regulation of cell differentiation|positive regulation of transcription by RNA polymerase II|neuron fate commitment|neuron fate specification|neuron development|regulation of axonogenesis|neuroendocrine cell differentiation|cellular response to organic substance|sequence-specific double-stranded DNA binding","WP3584,WP706","MECP2 and associated Rett syndrome|Sudden infant death syndrome (SIDS) susceptibility pathways","R-HSA-1266738,R-HSA-9619665,R-HSA-9675108","Developmental Biology|EGR2 and SOX10-mediated initiation of Schwann cell myelination|Nervous system development","POU"]
["PPFIA3",0.665094302514433,0.400115488495438,0.426949973768872,0.55063486037205,0.633237997790778,0.432385922644596,0.259878819850672,0.457090006504239,0.463150184012753,0.427047373864765,0.470448557024418,0.4403742726096,0.275704598363736,0.422723994275519,0.301337067593796,0.16708481424748,0.388041023729995,0.373440783741077,0.499110787971361,0.464643990032195,0.574096518773719,0.399850871294838,0.426505826237438,0.533151937734449,0.349420307521849,0.610353772310645,0.385059554543666,0.68939540325026,8541,"PTPRF interacting protein alpha 3","protein_coding",null,null,"GO:0001669,GO:0005515,GO:0005829,GO:0007269,GO:0016081,GO:0048172,GO:0048786,GO:0050808,GO:0098831,GO:0098875,GO:0098978","acrosomal vesicle|protein binding|cytosol|neurotransmitter secretion|synaptic vesicle docking|regulation of short-term neuronal synaptic plasticity|presynaptic active zone|synapse organization|presynaptic active zone cytoplasmic component|epididymosome|glutamatergic synapse",null,null,"R-HSA-112310,R-HSA-112315,R-HSA-112316,R-HSA-181429,R-HSA-181430,R-HSA-210500,R-HSA-212676,R-HSA-264642,R-HSA-388844,R-HSA-6794362","Neurotransmitter release cycle|Transmission across Chemical Synapses|Neuronal System|Serotonin Neurotransmitter Release Cycle|Norepinephrine Neurotransmitter Release Cycle|Glutamate Neurotransmitter Release Cycle|Dopamine Neurotransmitter Release Cycle|Acetylcholine Neurotransmitter Release Cycle|Receptor-type tyrosine-protein phosphatases|Protein-protein interactions at synapses"]
["PPIAL4F",0.0354687042568988,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,728945,"peptidylprolyl isomerase A like 4F","protein_coding",null,null,"GO:0000413,GO:0003755,GO:0005737,GO:0006457,GO:0016018","protein peptidyl-prolyl isomerization|peptidyl-prolyl cis-trans isomerase activity|cytoplasm|protein folding|cyclosporin A binding"]
["PPM1J",0.204452040874072,0.344058436628744,0.295302913595681,0.211164591600792,0.122942724949287,0.221527944723267,0.234771578831117,0.447235844796439,0.300566902049793,0.196913520698825,0.458502696905852,0.348100483533043,0.104694195873497,0.314870753657248,0.160887061350566,0.208763252310418,0.302412696522037,0.582068531398487,0.18895893653063,0.438581318012543,0.311724661842138,0.418576739151687,0.0931565418542929,0.199744046295081,0.280659462574199,0.343701761293423,0.106531645720307,0.561840447948422,333926,"protein phosphatase%2C Mg2+/Mn2+ dependent 1J","protein_coding",null,null,"GO:0004741,GO:0005515,GO:0005739,GO:0006470,GO:0017018","[pyruvate dehydrogenase (lipoamide)] phosphatase activity|protein binding|mitochondrion|protein dephosphorylation|myosin phosphatase activity","WP399","Wnt signaling pathway and pluripotency"]
["PPP1R13B",0.584741919339421,0.460419355338179,0.585332712386026,0.4790953495032,0.495705031672233,0.42909993656247,0.672012986798552,0.664531907557336,0.888099416945862,0.682531120964437,0.739291005495206,0.981796931289001,0.603959194763817,0.727308124437506,0.741882007155494,0.514035647838035,0.752074005828414,0.455047815607527,0.411586487126657,0.59209097123722,0.420328552244846,0.500604963383827,0.466402771490386,0.658292524182643,0.706421959399197,0.485698806949991,0.65203217708953,0.455070414765533,23368,"protein phosphatase 1 regulatory subunit 13B","protein_coding",null,null,"GO:0002039,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0042981,GO:0045786,GO:0048471,GO:0072332","p53 binding|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|plasma membrane|regulation of apoptotic process|negative regulation of cell cycle|perinuclear region of cytoplasm|intrinsic apoptotic signaling pathway by p53 class mediator","WP4861","Endoplasmic reticulum stress response in coronavirus infection","R-HSA-109581,R-HSA-109606,R-HSA-114452,R-HSA-139915,R-HSA-212436,R-HSA-3700989,R-HSA-5357801,R-HSA-5633007,R-HSA-5633008,R-HSA-6803204,R-HSA-6803205,R-HSA-6803211,R-HSA-6804759,R-HSA-73857,R-HSA-74160","Apoptosis|Intrinsic Pathway for Apoptosis|Activation of BH3-only proteins|Activation of PUMA and translocation to mitochondria|Generic Transcription Pathway|Transcriptional Regulation by TP53|Programmed Cell Death|Regulation of TP53 Activity|TP53 Regulates Transcription of Cell Death Genes|TP53 Regulates Transcription of Genes Involved in Cytochrome C Release|TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain|TP53 Regulates Transcription of Death Receptors and Ligands|Regulation of TP53 Activity through Association with Co-factors|RNA Polymerase II Transcription|Gene expression (Transcription)"]
["PPP2R3A",4.33068912057788,4.12724395448016,3.02620820437456,2.99411078173606,4.64475674401476,3.38674323882283,3.21241605280133,3.1027973070244,4.19170558937597,2.54005474677543,2.3689329196532,3.53495136350911,4.17203767622646,2.5841822825552,3.55584912360823,3.47566858555849,3.72213226281212,3.6733318624155,3.50773457145625,4.44085024059524,3.80562985231333,3.99863635653305,4.75099986336616,3.86209725237979,4.09241673994193,3.38939879691907,3.48182177509597,3.11244951160437,5523,"protein phosphatase 2 regulatory subunit B''alpha","protein_coding","hsa03015,hsa04071,hsa04151,hsa04152,hsa04660,hsa04261,hsa04728,hsa05165","mRNA surveillance pathway|Sphingolipid signaling pathway|PI3K-Akt signaling pathway|AMPK signaling pathway|T cell receptor signaling pathway|Adrenergic signaling in cardiomyocytes|Dopaminergic synapse|Human papillomavirus infection","GO:0000159,GO:0005509,GO:0005515,GO:0006470,GO:0019888,GO:0061053","protein phosphatase type 2A complex|calcium ion binding|protein binding|protein dephosphorylation|protein phosphatase regulator activity|somite development","WP399,WP3932,WP500,WP4172","Wnt signaling pathway and pluripotency|Focal adhesion: PI3K-Akt-mTOR-signaling pathway|Glycogen synthesis and degradation|PI3K-Akt signaling pathway"]
["PPP6R3",8.62778633076337,8.00343194915371,6.53912273848423,5.89076796191335,8.20841551904262,7.17885947301495,6.43290453360136,6.44443036579376,8.27158426696283,6.9815244195679,6.25977349218256,6.85775229327354,8.18892301067954,6.52794974236527,7.36297934108981,7.50673640760649,7.9386641165138,7.37230912172289,7.49637570737966,8.42899839437954,8.20432003631724,7.59235878716043,9.69312032598718,8.97239357393164,7.76022341831063,6.88499611626912,7.98477089522243,6.77246620393756,55291,"protein phosphatase 6 regulatory subunit 3","protein_coding",null,null,"GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0005886,GO:0019888,GO:0019903,GO:0043666","protein binding|nucleus|nucleoplasm|cytosol|plasma membrane|protein phosphatase regulator activity|protein phosphatase binding|regulation of phosphoprotein phosphatase activity",null,null,"R-HSA-157579,R-HSA-1640170,R-HSA-171319,R-HSA-180786,R-HSA-199977,R-HSA-199991,R-HSA-204005,R-HSA-392499,R-HSA-446203,R-HSA-5653656,R-HSA-597592,R-HSA-73886,R-HSA-948021","Telomere Maintenance|Cell Cycle|Telomere Extension By Telomerase|Extension of Telomeres|ER to Golgi Anterograde Transport|Membrane Trafficking|COPII-mediated vesicle transport|Metabolism of proteins|Asparagine N-linked glycosylation|Vesicle-mediated transport|Post-translational protein modification|Chromosome Maintenance|Transport to the Golgi and subsequent modification"]
["PRADC1",14.7393617249586,9.66786365843102,7.52258434975097,12.0961609503222,9.4245749907799,11.0774540667253,7.19887199933251,10.1610116328402,11.666610974561,14.2435317669524,10.7217443021884,13.0375969924284,9.45442102153656,7.59194792090277,6.04878993242126,6.23723309609273,17.4522089720026,16.475209477712,19.9308072131385,15.7670330694631,18.4401002889456,17.5598976601171,18.1399147346369,15.8737735388001,16.1576024527821,21.2190527095255,19.2646354935135,19.8318283968954,84279,"protease associated domain containing 1","protein_coding",null,null,"GO:0005515,GO:0005576","protein binding|extracellular region"]
["PRDM5",1.71543238220367,1.28449893320357,1.12316843840367,0.910110358495557,1.700024885504,1.17674097840635,1.16157980327381,1.15324543099307,1.62351297938216,0.933501939570088,1.04499906610344,1.17913879204671,1.75091699121272,1.27588669205307,1.40676775355617,1.59957455796797,1.26328161001776,0.983106481337656,1.2331193721082,1.15822709018239,1.09854765991146,1.16415053156961,1.30516328049426,1.2440713189273,1.08556563604372,0.890125085235904,1.22831589673798,0.834946519540305,11107,"PR/SET domain 5","protein_coding",null,null,"GO:0000122,GO:0000278,GO:0000976,GO:0000977,GO:0000978,GO:0001227,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0006325,GO:0008168,GO:0016604,GO:0032259,GO:0043565,GO:0045892,GO:0045944,GO:0046872,GO:0140297,GO:1903053,GO:1990830","negative regulation of transcription by RNA polymerase II|mitotic cell cycle|transcription cis-regulatory region binding|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|nucleolus|chromatin organization|methyltransferase activity|nuclear body|methylation|sequence-specific DNA binding|negative regulation of DNA-templated transcription|positive regulation of transcription by RNA polymerase II|metal ion binding|DNA-binding transcription factor binding|regulation of extracellular matrix organization|cellular response to leukemia inhibitory factor"]
["PRICKLE4",2.40172609364417,2.76537472629152,2.59601726063964,2.36401076706524,1.92998819023921,2.240505411708,2.28501485009023,2.21567692184373,0.874142094657679,1.21745792939953,1.5305559716589,0.89022905284652,1.1720630074292,1.19006836570405,0.822902253899219,0.823987263243306,0.850726267965159,1.38889535415615,1.03684592037868,1.03322007068355,1.1036093677611,1.12644531523089,1.01392832434415,1.15777334075357,0.892922631710763,1.27615856065138,0.611606902577814,1.12895020842156,29964,"prickle planar cell polarity protein 4","protein_coding","hsa04310","Wnt signaling pathway","GO:0001725,GO:0003674,GO:0003779,GO:0005634,GO:0005912,GO:0007507,GO:0008150,GO:0008270,GO:0030018,GO:0030036,GO:0031941,GO:0051371,GO:0061061","stress fiber|molecular_function|actin binding|nucleus|adherens junction|heart development|biological_process|zinc ion binding|Z disc|actin cytoskeleton organization|filamentous actin|muscle alpha-actinin binding|muscle structure development"]
["PRKAB1",13.6125525813883,12.3297119079401,12.5064711461069,12.9800148701027,11.8017606684849,13.424654832315,12.0523029533552,11.8323090306653,12.2837012823981,13.7904434996678,13.6342003527557,12.1736523667665,12.2954822997956,12.0593018372058,12.3991122026107,11.3027166662362,10.588604752442,11.382342873785,10.3236776763814,11.3555437776746,11.4206498838067,11.320497630226,10.2420829589655,10.9785913177255,11.1631931847796,11.5930309685061,11.0584933843901,11.3543783190129,5564,"protein kinase AMP-activated non-catalytic subunit beta 1","protein_coding","hsa04371,hsa04068,hsa04152,hsa04530,hsa04910,hsa04922,hsa04920,hsa04921,hsa04211,hsa04213,hsa04710,hsa04714,hsa05410,hsa04936,hsa04932,hsa04931","Apelin signaling pathway|FoxO signaling pathway|AMPK signaling pathway|Tight junction|Insulin signaling pathway|Glucagon signaling pathway|Adipocytokine signaling pathway|Oxytocin signaling pathway|Longevity regulating pathway|Longevity regulating pathway - multiple species|Circadian rhythm|Thermogenesis|Hypertrophic cardiomyopathy|Alcoholic liver disease|Non-alcoholic fatty liver disease|Insulin resistance","GO:0004672,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006468,GO:0006633,GO:0007165,GO:0010628,GO:0019901,GO:0031588,GO:0031669,GO:0035878,GO:0120162","protein kinase activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|protein phosphorylation|fatty acid biosynthetic process|signal transduction|positive regulation of gene expression|protein kinase binding|nucleotide-activated protein kinase complex|cellular response to nutrient levels|nail development|positive regulation of cold-induced thermogenesis","WP4963,WP3850,WP4321,WP4540,WP3934,WP1982,WP3965,WP4206,WP5381,WP1403,WP4396,WP1541,WP4923,WP4539,WP5087,WP3915,WP4905,WP1471","p53 transcriptional gene network|Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling|Thermogenesis|Hippo signaling regulation pathways|Leptin and adiponectin|Sterol regulatory element-binding proteins (SREBP) signaling|Lipid metabolism pathway|Hereditary leiomyomatosis and renal cell carcinoma pathway|Smith-Magenis and Potocki-Lupski syndrome copy number variation|AMP-activated protein kinase signaling|Nonalcoholic fatty liver disease|Energy metabolism|Autophagy|Synaptic signaling pathways associated with autism spectrum disorder|Pleural mesothelioma|Angiopoietin-like protein 8 regulatory pathway|1q21.1 copy number variation syndrome|Target of rapamycin signaling","R-HSA-112314,R-HSA-112315,R-HSA-112316,R-HSA-1445148,R-HSA-1592230,R-HSA-162582,R-HSA-1632852,R-HSA-1632852,R-HSA-165159,R-HSA-1852241,R-HSA-199991,R-HSA-212436,R-HSA-2151209,R-HSA-3700989,R-HSA-380972,R-HSA-438064,R-HSA-442755,R-HSA-5628897,R-HSA-5633007,R-HSA-5653656,R-HSA-6804756,R-HSA-73857,R-HSA-74160,R-HSA-9612973,R-HSA-9612973,R-HSA-9613354,R-HSA-9619483,R-HSA-9663891","Neurotransmitter receptors and postsynaptic signal transmission|Transmission across Chemical Synapses|Neuronal System|Translocation of SLC2A4 (GLUT4) to the plasma membrane|Mitochondrial biogenesis|Signal Transduction|Macroautophagy|Macroautophagy|MTOR signalling|Organelle biogenesis and maintenance|Membrane Trafficking|Generic Transcription Pathway|Activation of PPARGC1A (PGC-1alpha) by phosphorylation|Transcriptional Regulation by TP53|Energy dependent regulation of mTOR by LKB1-AMPK|Post NMDA receptor activation events|Activation of NMDA receptors and postsynaptic events|TP53 Regulates Metabolic Genes|Regulation of TP53 Activity|Vesicle-mediated transport|Regulation of TP53 Activity through Phosphorylation|RNA Polymerase II Transcription|Gene expression (Transcription)|Autophagy|Autophagy|Lipophagy|Activation of AMPK downstream of NMDARs|Selective autophagy"]
["PRKCZ-AS1",0.602373524809902,0.859435745030364,0.28276491279497,0.412650906400363,0.693723703968635,0.626265805529454,0.501793802519622,0.611781514749479,0.476069086507901,0.84952426506165,1.41624368804583,0.714258853282884,0.552392885262079,0.861434112958537,0.840306012660855,0.897508233738598,0.330940374677587,0.617071615070376,0.556726458467556,0.413753683063268,0.223359433526077,0.695273573446692,0.446006460162732,0.420358886794486,0.362590024850892,0.551921652699158,0.499633539887191,0.525850752349592,100506504,"PRKCZ antisense RNA 1","non_coding"]
["PRODH",0,0,0,0.0436883469133633,0,0.0106942373540538,0.0106252240736305,0,0.0458205296612052,0.0109684369854013,0,0,0,0.0108573937628205,0,0,0,0,0,0.0109512751347333,0,0,0,0,0.0112906707705998,0.043283908734735,0,0,5625,"proline dehydrogenase 1","protein_coding","hsa00330","Arginine and proline metabolism","GO:0004657,GO:0005654,GO:0005739,GO:0005743,GO:0005759,GO:0006560,GO:0006562,GO:0008631,GO:0010133,GO:0019470,GO:0043231,GO:0071949,GO:1903376","proline dehydrogenase activity|nucleoplasm|mitochondrion|mitochondrial inner membrane|mitochondrial matrix|proline metabolic process|proline catabolic process|intrinsic apoptotic signaling pathway in response to oxidative stress|proline catabolic process to glutamate|4-hydroxyproline catabolic process|intracellular membrane-bounded organelle|FAD binding|regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway","WP4657","22q11.2 copy number variation syndrome","R-HSA-1430728,R-HSA-70688,R-HSA-71291","Metabolism|Proline catabolism|Metabolism of amino acids and derivatives"]
["PRPF4",17.9677528566999,16.9332820583874,13.0024716365009,14.6020012299188,15.9709878386954,15.4170585479793,11.3298655073641,14.3813051416946,14.8256813787745,14.6374668597296,13.2834887732804,15.3548825618277,12.4643038019798,11.3588250753789,11.3190659014047,11.6792044918061,13.3155222248476,15.2840719507777,13.9444444818019,14.4910857178463,15.7296125976137,15.0999732602097,13.4099882706907,13.7815497748565,15.2402618879484,15.1553068922022,13.8279971375714,15.3138221140709,9128,"pre-mRNA processing factor 4","protein_coding","hsa03040","Spliceosome","GO:0000375,GO:0000398,GO:0005515,GO:0005634,GO:0005654,GO:0005681,GO:0006396,GO:0008380,GO:0015030,GO:0016607,GO:0017070,GO:0030621,GO:0046540,GO:0071001,GO:0071005,GO:0097525","RNA splicing, via transesterification reactions|mRNA splicing, via spliceosome|protein binding|nucleus|nucleoplasm|spliceosomal complex|RNA processing|RNA splicing|Cajal body|nuclear speck|U6 snRNA binding|U4 snRNA binding|U4/U6 x U5 tri-snRNP complex|U4/U6 snRNP|U2-type precatalytic spliceosome|spliceosomal snRNP complex","WP411","mRNA processing","R-HSA-72163,R-HSA-72172,R-HSA-72203,R-HSA-8953854","mRNA Splicing - Major Pathway|mRNA Splicing|Processing of Capped Intron-Containing Pre-mRNA|Metabolism of RNA"]
["PRR35",0,0,0,0,0,0,0,0,0,0,0,7.17275647105907E-3,0,0,0,0,0.00685447450196736,0,0.0065891322444917,0,0,0,0,0,0,0,0.00689897762362967,0,146325,"proline rich 35","protein_coding",null,null,"GO:0005515","protein binding"]
["PRRC2B",22.0092033780643,25.0080646750367,22.9539531104114,20.8706550607761,24.3561611983952,23.7774292514434,22.1002877818352,21.2810098500631,23.5750479567247,28.5761745617609,23.4633918509134,23.4604153286446,23.5567818627224,25.263674775974,24.8189473040882,26.2447839008281,18.1621085233182,20.3335023564068,14.0772437240197,21.8307010839849,19.2904108551153,19.3116333718718,14.4610002396081,16.5739345420991,20.3618058658273,16.705278933062,13.4560351409402,17.0677202640124,84726,"proline rich coiled-coil 2B","protein_coding",null,null,"GO:0003723,GO:0005515,GO:0030154","RNA binding|protein binding|cell differentiation"]
["PRSS48",0,0,0,0,0,0,0.00972917036065124,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,345062,"serine protease 48","protein_coding",null,null,"GO:0004252,GO:0005615,GO:0006508","serine-type endopeptidase activity|extracellular space|proteolysis"]
["PSAT1",52.3605540720837,55.8706607070574,66.8479454413591,48.6816021550192,55.2720201539263,57.6146317050701,74.6972711082145,60.7387998925529,68.5355068128075,49.2883372450299,47.3344463934668,56.8958520311061,82.0068239631308,79.7312071144449,85.3100427191796,88.6440377164192,29.13580456392,23.5735776288923,19.0182906544227,26.8147084916642,31.6822368730675,26.3430113342635,18.9273738808043,24.2224376966553,29.6446592684415,25.6132529937794,18.7537917272805,22.7457313190284,29968,"phosphoserine aminotransferase 1","protein_coding","hsa00260,hsa00270,hsa00750","Glycine, serine and threonine metabolism|Cysteine and methionine metabolism|Vitamin B6 metabolism","GO:0004648,GO:0005515,GO:0005737,GO:0005829,GO:0006564,GO:0008615,GO:0030170,GO:0042802,GO:0070062","O-phospho-L-serine:2-oxoglutarate aminotransferase activity|protein binding|cytoplasm|cytosol|L-serine biosynthetic process|pyridoxine biosynthetic process|pyridoxal phosphate binding|identical protein binding|extracellular exosome","WP5083,WP2525,WP4688,WP4018,WP5213,WP5312,WP5355,WP4290,WP4673","Neuroinflammation and glutamatergic signaling|Trans-sulfuration, one-carbon metabolism and related pathways|Serine metabolism|Clear cell renal cell carcinoma pathways|Amino acid metabolism in triple-negative breast cancer cells|Metabolic pathways of fibroblasts|Metabolic Epileptic Disorders|Metabolic reprogramming in colon cancer|Male infertility","R-HSA-1430728,R-HSA-71291,R-HSA-977347","Metabolism|Metabolism of amino acids and derivatives|Serine biosynthesis"]
["PSMA3",79.4573255363449,68.2475975274391,86.8138617395927,89.523015391356,69.4506027955278,69.2337535519607,86.5367424986214,81.2370524814775,78.872796890321,50.7012266936021,76.3442843540047,76.6180927766142,78.0327735184584,65.3654100187356,74.1836226402346,67.0411097398984,123.857727300112,102.796106325857,134.480773800692,111.748176083971,131.182939448363,112.713824619898,179.872926479137,137.054823833133,128.475975209444,120.744361233502,164.485944634923,125.701435054034,5684,"proteasome 20S subunit alpha 3","protein_coding","hsa03050,hsa05010,hsa05012,hsa05014,hsa05016,hsa05017,hsa05020,hsa05022","Proteasome|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Spinocerebellar ataxia|Prion disease|Pathways of neurodegeneration - multiple diseases","GO:0000502,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005839,GO:0010498,GO:0019773,GO:0031625,GO:0043161,GO:0045202,GO:0052548,GO:0070062","proteasome complex|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|proteasome core complex|proteasomal protein catabolic process|proteasome core complex, alpha-subunit complex|ubiquitin protein ligase binding|proteasome-mediated ubiquitin-dependent protein catabolic process|synapse|regulation of endopeptidase activity|extracellular exosome","WP5124,WP183,WP2059","Alzheimer's disease|Proteasome degradation|Alzheimer's disease and miRNA effects","R-HSA-109581,R-HSA-1168372,R-HSA-1169091,R-HSA-1234174,R-HSA-1234176,R-HSA-1236974,R-HSA-1236975,R-HSA-1236975,R-HSA-1236978,R-HSA-1257604,R-HSA-1266738,R-HSA-1280215,R-HSA-1280218,R-HSA-1280218,R-HSA-1430728,R-HSA-157118,R-HSA-162582,R-HSA-162582,R-HSA-162906,R-HSA-162909,R-HSA-1640170,R-HSA-1643685,R-HSA-168249,R-HSA-168256,R-HSA-168256,R-HSA-169911,R-HSA-174084,R-HSA-174113,R-HSA-174143,R-HSA-174154,R-HSA-174178,R-HSA-174184,R-HSA-176408,R-HSA-176409,R-HSA-176814,R-HSA-179419,R-HSA-180534,R-HSA-180585,R-HSA-187577,R-HSA-195253,R-HSA-195721,R-HSA-201681,R-HSA-202403,R-HSA-202424,R-HSA-211733,R-HSA-212436,R-HSA-212436,R-HSA-2262752,R-HSA-2454202,R-HSA-2467813,R-HSA-2555396,R-HSA-2871837,R-HSA-349425,R-HSA-350562,R-HSA-351202,R-HSA-376176,R-HSA-382551,R-HSA-382556,R-HSA-3858494,R-HSA-392499,R-HSA-4086400,R-HSA-422475,R-HSA-446652,R-HSA-449147,R-HSA-450408,R-HSA-450531,R-HSA-453274,R-HSA-453276,R-HSA-453279,R-HSA-4608870,R-HSA-4641257,R-HSA-4641258,R-HSA-5357801,R-HSA-5358346,R-HSA-5358351,R-HSA-5358351,R-HSA-5362768,R-HSA-5387390,R-HSA-5607761,R-HSA-5607764,R-HSA-5610780,R-HSA-5610783,R-HSA-5610785,R-HSA-5610787,R-HSA-5610787,R-HSA-5619084,R-HSA-5619115,R-HSA-5621481,R-HSA-5632684,R-HSA-5658442,R-HSA-5663202,R-HSA-5663205,R-HSA-5668541,R-HSA-5673001,R-HSA-5676590,R-HSA-5678895,R-HSA-5683057,R-HSA-5684996,R-HSA-5687128,R-HSA-5688426,R-HSA-5689603,R-HSA-5689880,R-HSA-597592,R-HSA-6807070,R-HSA-68867,R-HSA-68882,R-HSA-68886,R-HSA-68949,R-HSA-69002,R-HSA-69017,R-HSA-69052,R-HSA-69202,R-HSA-69206,R-HSA-69239,R-HSA-69242,R-HSA-69275,R-HSA-69278,R-HSA-69306,R-HSA-69481,R-HSA-69541,R-HSA-69563,R-HSA-69580,R-HSA-69601,R-HSA-69610,R-HSA-69613,R-HSA-69615,R-HSA-69620,R-HSA-69656,R-HSA-71291,R-HSA-73857,R-HSA-73857,R-HSA-74160,R-HSA-74160,R-HSA-75815,R-HSA-8852276,R-HSA-8854050,R-HSA-8878159,R-HSA-8878166,R-HSA-8878166,R-HSA-8878171,R-HSA-8939236,R-HSA-8939902,R-HSA-8939902,R-HSA-8941858,R-HSA-8948751,R-HSA-8951664,R-HSA-8953854,R-HSA-8953897,R-HSA-9006925,R-HSA-9010553,R-HSA-9013694,R-HSA-9020702,R-HSA-9604323,R-HSA-9675108,R-HSA-9711123,R-HSA-9755511,R-HSA-9758941,R-HSA-9759194,R-HSA-9762114,R-HSA-9793380,R-HSA-9824272,R-HSA-9824446,R-HSA-983168,R-HSA-983169,R-HSA-983169,R-HSA-983705","Apoptosis|Downstream signaling events of B Cell Receptor (BCR)|Activation of NF-kappaB in B cells|Cellular response to hypoxia|Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha|ER-Phagosome pathway|Antigen processing-Cross presentation|Antigen processing-Cross presentation|Cross-presentation of soluble exogenous antigens (endosomes)|PIP3 activates AKT signaling|Developmental Biology|Cytokine Signaling in Immune system|Adaptive Immune System|Adaptive Immune System|Metabolism|Signaling by NOTCH|Signal Transduction|Signal Transduction|HIV Infection|Host Interactions of HIV factors|Cell Cycle|Disease|Innate Immune System|Immune System|Immune System|Regulation of Apoptosis|Autodegradation of Cdh1 by Cdh1:APC/C|SCF-beta-TrCP mediated degradation of Emi1|APC/C-mediated degradation of cell cycle proteins|APC/C:Cdc20 mediated degradation of Securin|APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1|Cdc20:Phospho-APC/C mediated degradation of Cyclin A|Regulation of APC/C activators between G1/S and early anaphase|APC/C:Cdc20 mediated degradation of mitotic proteins|Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins|APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint|Vpu mediated degradation of CD4|Vif-mediated degradation of APOBEC3G|SCF(Skp2)-mediated degradation of p27/p21|Degradation of beta-catenin by the destruction complex|Signaling by WNT|TCF dependent signaling in response to WNT|TCR signaling|Downstream TCR signaling|Regulation of activated PAK-2p34 by proteasome mediated degradation|Generic Transcription Pathway|Generic Transcription Pathway|Cellular responses to stress|Fc epsilon receptor (FCERI) signaling|Separation of Sister Chromatids|Mitotic Metaphase and Anaphase|FCERI mediated NF-kB activation|Autodegradation of the E3 ubiquitin ligase COP1|Regulation of ornithine decarboxylase (ODC)|Metabolism of polyamines|Signaling by ROBO receptors|Transport of small molecules|ABC-family proteins mediated transport|Beta-catenin independent WNT signaling|Metabolism of proteins|PCP/CE pathway|Axon guidance|Interleukin-1 family signaling|Signaling by Interleukins|AUF1 (hnRNP D0) binds and destabilizes mRNA|Regulation of mRNA stability by proteins that bind AU-rich elements|Mitotic G2-G2/M phases|Regulation of mitotic cell cycle|Mitotic G1 phase and G1/S transition|Asymmetric localization of PCP proteins|Degradation of AXIN|Degradation of DVL|Programmed Cell Death|Hedgehog ligand biogenesis|Signaling by Hedgehog|Signaling by Hedgehog|Hh mutants are degraded by ERAD|Hh mutants abrogate ligand secretion|Dectin-1 mediated noncanonical NF-kB signaling|CLEC7A (Dectin-1) signaling|Degradation of GLI1 by the proteasome|Degradation of GLI2 by the proteasome|GLI3 is processed to GLI3R by the proteasome|Hedgehog 'off' state|Hedgehog 'off' state|ABC transporter disorders|Disorders of transmembrane transporters|C-type lectin receptors (CLRs)|Hedgehog 'on' state|Regulation of RAS by GAPs|Diseases of signal transduction by growth factor receptors and second messengers|Infectious disease|TNFR2 non-canonical NF-kB pathway|RAF/MAP kinase cascade|NIK-->noncanonical NF-kB signaling|Defective CFTR causes cystic fibrosis|MAPK family signaling cascades|MAPK1/MAPK3 signaling|MAPK6/MAPK4 signaling|Deubiquitination|UCH proteinases|Ub-specific processing proteases|Post-translational protein modification|PTEN Regulation|Assembly of the pre-replicative complex|Mitotic Anaphase|M Phase|Orc1 removal from chromatin|DNA Replication Pre-Initiation|CDK-mediated phosphorylation and removal of Cdc6|Switching of origins to a post-replicative state|Cyclin E associated events during G1/S transition |G1/S Transition|Synthesis of DNA|S Phase|G2/M Transition|Cell Cycle, Mitotic|DNA Replication|G2/M Checkpoints|Stabilization of p53|p53-Dependent G1 DNA Damage Response|p53-Dependent G1/S DNA damage checkpoint|Ubiquitin Mediated Degradation of Phosphorylated Cdc25A|p53-Independent DNA Damage Response|p53-Independent G1/S DNA damage checkpoint|G1/S DNA Damage Checkpoints|Cell Cycle Checkpoints|Cyclin A:Cdk2-associated events at S phase entry|Metabolism of amino acids and derivatives|RNA Polymerase II Transcription|RNA Polymerase II Transcription|Gene expression (Transcription)|Gene expression (Transcription)|Ubiquitin-dependent degradation of Cyclin D|The role of GTSE1 in G2/M progression after G2 checkpoint|FBXL7 down-regulates AURKA during mitotic entry and in early mitosis|Transcriptional regulation by RUNX3|Transcriptional regulation by RUNX2|Transcriptional regulation by RUNX2|Transcriptional regulation by RUNX1|RUNX1 regulates transcription of genes involved in differentiation of HSCs|Regulation of RUNX2 expression and activity|Regulation of RUNX2 expression and activity|Regulation of RUNX3 expression and activity|Regulation of PTEN stability and activity|Neddylation|Metabolism of RNA|Cellular responses to stimuli|Intracellular signaling by second messengers|Regulation of expression of SLITs and ROBOs|Signaling by NOTCH4|Interleukin-1 signaling|Negative regulation of NOTCH4 signaling|Nervous system development|Cellular response to chemical stress|KEAP1-NFE2L2 pathway|Gastrulation|Nuclear events mediated by NFE2L2|GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2|Formation of paraxial mesoderm|Somitogenesis|Viral Infection Pathways|Antigen processing: Ubiquitination & Proteasome degradation|Class I MHC mediated antigen processing & presentation|Class I MHC mediated antigen processing & presentation|Signaling by the B Cell Receptor (BCR)"]
["PSMD1",43.509697062151,37.1037399432828,36.5175538511077,38.695280912807,38.9632255992066,34.3219742230654,33.1188823302033,35.5535436330485,42.036555505906,35.0221103699546,36.3575593809437,40.9684012221439,39.2460096040724,32.6733205442177,35.2473116978134,33.6275447340637,46.1833216160273,42.9883218764626,44.8615773212589,44.461946893198,42.1243652114719,41.5291788675211,45.7070098473604,48.1154771275897,44.9325932928387,40.6854397439296,44.8445718327856,43.2978820745292,5707,"proteasome 26S subunit%2C non-ATPase 1","protein_coding","hsa03050,hsa05169,hsa05010,hsa05012,hsa05014,hsa05016,hsa05017,hsa05020,hsa05022","Proteasome|Epstein-Barr virus infection|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Spinocerebellar ataxia|Prion disease|Pathways of neurodegeneration - multiple diseases","GO:0000502,GO:0005515,GO:0005576,GO:0005634,GO:0005654,GO:0005829,GO:0005838,GO:0008540,GO:0016020,GO:0022624,GO:0030234,GO:0031625,GO:0034515,GO:0035578,GO:0042176,GO:0043161","proteasome complex|protein binding|extracellular region|nucleus|nucleoplasm|cytosol|proteasome regulatory particle|proteasome regulatory particle, base subcomplex|membrane|proteasome accessory complex|enzyme regulator activity|ubiquitin protein ligase binding|proteasome storage granule|azurophil granule lumen|regulation of protein catabolic process|proteasome-mediated ubiquitin-dependent protein catabolic process","WP5124,WP183,WP2059,WP2359","Alzheimer's disease|Proteasome degradation|Alzheimer's disease and miRNA effects|Parkin-ubiquitin proteasomal system pathway","R-HSA-109581,R-HSA-1168372,R-HSA-1169091,R-HSA-1234174,R-HSA-1234176,R-HSA-1236974,R-HSA-1236975,R-HSA-1236975,R-HSA-1236978,R-HSA-1257604,R-HSA-1266738,R-HSA-1280215,R-HSA-1280218,R-HSA-1280218,R-HSA-1430728,R-HSA-157118,R-HSA-162582,R-HSA-162582,R-HSA-162906,R-HSA-162909,R-HSA-1640170,R-HSA-1643685,R-HSA-168249,R-HSA-168256,R-HSA-168256,R-HSA-169911,R-HSA-174084,R-HSA-174113,R-HSA-174143,R-HSA-174154,R-HSA-174178,R-HSA-174184,R-HSA-176408,R-HSA-176409,R-HSA-176814,R-HSA-179419,R-HSA-180534,R-HSA-180585,R-HSA-187577,R-HSA-195253,R-HSA-195721,R-HSA-201681,R-HSA-202403,R-HSA-202424,R-HSA-211733,R-HSA-212436,R-HSA-212436,R-HSA-2262752,R-HSA-2454202,R-HSA-2467813,R-HSA-2555396,R-HSA-2871837,R-HSA-349425,R-HSA-350562,R-HSA-351202,R-HSA-376176,R-HSA-382551,R-HSA-382556,R-HSA-3858494,R-HSA-392499,R-HSA-4086400,R-HSA-422475,R-HSA-446652,R-HSA-449147,R-HSA-450408,R-HSA-450531,R-HSA-453274,R-HSA-453276,R-HSA-453279,R-HSA-4608870,R-HSA-4641257,R-HSA-4641258,R-HSA-5357801,R-HSA-5358346,R-HSA-5358351,R-HSA-5358351,R-HSA-5362768,R-HSA-5387390,R-HSA-5607761,R-HSA-5607764,R-HSA-5610780,R-HSA-5610783,R-HSA-5610785,R-HSA-5610787,R-HSA-5610787,R-HSA-5619084,R-HSA-5619115,R-HSA-5621481,R-HSA-5632684,R-HSA-5658442,R-HSA-5663202,R-HSA-5663205,R-HSA-5668541,R-HSA-5673001,R-HSA-5676590,R-HSA-5678895,R-HSA-5683057,R-HSA-5684996,R-HSA-5687128,R-HSA-5688426,R-HSA-5689603,R-HSA-5689880,R-HSA-597592,R-HSA-6798695,R-HSA-6807070,R-HSA-68867,R-HSA-68882,R-HSA-68886,R-HSA-68949,R-HSA-69002,R-HSA-69017,R-HSA-69052,R-HSA-69202,R-HSA-69206,R-HSA-69239,R-HSA-69242,R-HSA-69275,R-HSA-69278,R-HSA-69306,R-HSA-69481,R-HSA-69541,R-HSA-69563,R-HSA-69580,R-HSA-69601,R-HSA-69610,R-HSA-69613,R-HSA-69615,R-HSA-69620,R-HSA-69656,R-HSA-71291,R-HSA-73857,R-HSA-73857,R-HSA-74160,R-HSA-74160,R-HSA-75815,R-HSA-8852276,R-HSA-8854050,R-HSA-8878159,R-HSA-8878166,R-HSA-8878166,R-HSA-8878171,R-HSA-8939236,R-HSA-8939902,R-HSA-8939902,R-HSA-8941858,R-HSA-8948751,R-HSA-8951664,R-HSA-8953854,R-HSA-8953897,R-HSA-9006925,R-HSA-9010553,R-HSA-9013694,R-HSA-9020702,R-HSA-9604323,R-HSA-9675108,R-HSA-9711123,R-HSA-9755511,R-HSA-9758941,R-HSA-9759194,R-HSA-9762114,R-HSA-9793380,R-HSA-9824272,R-HSA-9824446,R-HSA-983168,R-HSA-983169,R-HSA-983169,R-HSA-983705","Apoptosis|Downstream signaling events of B Cell Receptor (BCR)|Activation of NF-kappaB in B cells|Cellular response to hypoxia|Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha|ER-Phagosome pathway|Antigen processing-Cross presentation|Antigen processing-Cross presentation|Cross-presentation of soluble exogenous antigens (endosomes)|PIP3 activates AKT signaling|Developmental Biology|Cytokine Signaling in Immune system|Adaptive Immune System|Adaptive Immune System|Metabolism|Signaling by NOTCH|Signal Transduction|Signal Transduction|HIV Infection|Host Interactions of HIV factors|Cell Cycle|Disease|Innate Immune System|Immune System|Immune System|Regulation of Apoptosis|Autodegradation of Cdh1 by Cdh1:APC/C|SCF-beta-TrCP mediated degradation of Emi1|APC/C-mediated degradation of cell cycle proteins|APC/C:Cdc20 mediated degradation of Securin|APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1|Cdc20:Phospho-APC/C mediated degradation of Cyclin A|Regulation of APC/C activators between G1/S and early anaphase|APC/C:Cdc20 mediated degradation of mitotic proteins|Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins|APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint|Vpu mediated degradation of CD4|Vif-mediated degradation of APOBEC3G|SCF(Skp2)-mediated degradation of p27/p21|Degradation of beta-catenin by the destruction complex|Signaling by WNT|TCF dependent signaling in response to WNT|TCR signaling|Downstream TCR signaling|Regulation of activated PAK-2p34 by proteasome mediated degradation|Generic Transcription Pathway|Generic Transcription Pathway|Cellular responses to stress|Fc epsilon receptor (FCERI) signaling|Separation of Sister Chromatids|Mitotic Metaphase and Anaphase|FCERI mediated NF-kB activation|Autodegradation of the E3 ubiquitin ligase COP1|Regulation of ornithine decarboxylase (ODC)|Metabolism of polyamines|Signaling by ROBO receptors|Transport of small molecules|ABC-family proteins mediated transport|Beta-catenin independent WNT signaling|Metabolism of proteins|PCP/CE pathway|Axon guidance|Interleukin-1 family signaling|Signaling by Interleukins|AUF1 (hnRNP D0) binds and destabilizes mRNA|Regulation of mRNA stability by proteins that bind AU-rich elements|Mitotic G2-G2/M phases|Regulation of mitotic cell cycle|Mitotic G1 phase and G1/S transition|Asymmetric localization of PCP proteins|Degradation of AXIN|Degradation of DVL|Programmed Cell Death|Hedgehog ligand biogenesis|Signaling by Hedgehog|Signaling by Hedgehog|Hh mutants are degraded by ERAD|Hh mutants abrogate ligand secretion|Dectin-1 mediated noncanonical NF-kB signaling|CLEC7A (Dectin-1) signaling|Degradation of GLI1 by the proteasome|Degradation of GLI2 by the proteasome|GLI3 is processed to GLI3R by the proteasome|Hedgehog 'off' state|Hedgehog 'off' state|ABC transporter disorders|Disorders of transmembrane transporters|C-type lectin receptors (CLRs)|Hedgehog 'on' state|Regulation of RAS by GAPs|Diseases of signal transduction by growth factor receptors and second messengers|Infectious disease|TNFR2 non-canonical NF-kB pathway|RAF/MAP kinase cascade|NIK-->noncanonical NF-kB signaling|Defective CFTR causes cystic fibrosis|MAPK family signaling cascades|MAPK1/MAPK3 signaling|MAPK6/MAPK4 signaling|Deubiquitination|UCH proteinases|Ub-specific processing proteases|Post-translational protein modification|Neutrophil degranulation|PTEN Regulation|Assembly of the pre-replicative complex|Mitotic Anaphase|M Phase|Orc1 removal from chromatin|DNA Replication Pre-Initiation|CDK-mediated phosphorylation and removal of Cdc6|Switching of origins to a post-replicative state|Cyclin E associated events during G1/S transition |G1/S Transition|Synthesis of DNA|S Phase|G2/M Transition|Cell Cycle, Mitotic|DNA Replication|G2/M Checkpoints|Stabilization of p53|p53-Dependent G1 DNA Damage Response|p53-Dependent G1/S DNA damage checkpoint|Ubiquitin Mediated Degradation of Phosphorylated Cdc25A|p53-Independent DNA Damage Response|p53-Independent G1/S DNA damage checkpoint|G1/S DNA Damage Checkpoints|Cell Cycle Checkpoints|Cyclin A:Cdk2-associated events at S phase entry|Metabolism of amino acids and derivatives|RNA Polymerase II Transcription|RNA Polymerase II Transcription|Gene expression (Transcription)|Gene expression (Transcription)|Ubiquitin-dependent degradation of Cyclin D|The role of GTSE1 in G2/M progression after G2 checkpoint|FBXL7 down-regulates AURKA during mitotic entry and in early mitosis|Transcriptional regulation by RUNX3|Transcriptional regulation by RUNX2|Transcriptional regulation by RUNX2|Transcriptional regulation by RUNX1|RUNX1 regulates transcription of genes involved in differentiation of HSCs|Regulation of RUNX2 expression and activity|Regulation of RUNX2 expression and activity|Regulation of RUNX3 expression and activity|Regulation of PTEN stability and activity|Neddylation|Metabolism of RNA|Cellular responses to stimuli|Intracellular signaling by second messengers|Regulation of expression of SLITs and ROBOs|Signaling by NOTCH4|Interleukin-1 signaling|Negative regulation of NOTCH4 signaling|Nervous system development|Cellular response to chemical stress|KEAP1-NFE2L2 pathway|Gastrulation|Nuclear events mediated by NFE2L2|GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2|Formation of paraxial mesoderm|Somitogenesis|Viral Infection Pathways|Antigen processing: Ubiquitination & Proteasome degradation|Class I MHC mediated antigen processing & presentation|Class I MHC mediated antigen processing & presentation|Signaling by the B Cell Receptor (BCR)"]
["PSTK",1.54436649785247,0.877553810091768,1.12979730781919,1.34648850447827,1.19551280360377,1.46907311438209,1.51573090473583,2.04542469083626,1.33150572632678,1.19766517958005,1.33921436245345,1.31161643906981,1.4114575922418,1.62533730514188,1.23107331765567,1.31215958746513,1.88976434003718,1.54029452034619,2.65076770040811,1.75511295401499,1.45765296983424,1.65862367636111,2.71265288258201,1.66556262046305,1.84927577931764,1.79140311117207,2.40665495905731,1.88556259356123,118672,"phosphoseryl-tRNA kinase","protein_coding","hsa00450,hsa00970","Selenocompound metabolism|Aminoacyl-tRNA biosynthesis","GO:0000049,GO:0005524,GO:0006412,GO:0016301,GO:0016310,GO:0043915","tRNA binding|ATP binding|translation|kinase activity|phosphorylation|L-seryl-tRNA(Sec) kinase activity",null,null,"R-HSA-1430728,R-HSA-2408522,R-HSA-2408557,R-HSA-71291","Metabolism|Selenoamino acid metabolism|Selenocysteine synthesis|Metabolism of amino acids and derivatives"]
["PTGDS",28.3173049207664,28.986904863481,19.5415975724864,35.6587300496314,35.7802316981336,37.7516719685245,17.9642181302024,37.3059421066051,6.244302716567,6.90622501773415,5.71328749868439,6.1788615272891,5.96679556235677,9.08342665948664,3.73567075702411,6.13783795036163,0.989433264593714,0.982921638243358,0.153408306751374,0.670387971825356,1.15933348608402,0.946657984130004,0.131092210786747,1.07028445874785,0.921552334965857,0.851672205458184,0.289119839352825,0.905070044909394,5730,"prostaglandin D2 synthase","protein_coding","hsa00590","Arachidonic acid metabolism","GO:0001516,GO:0004667,GO:0005501,GO:0005504,GO:0005515,GO:0005576,GO:0005615,GO:0005789,GO:0005791,GO:0005794,GO:0010467,GO:0019371,GO:0031965,GO:0043303,GO:0045187,GO:0048471,GO:0051384,GO:0070062,GO:2000255","prostaglandin biosynthetic process|prostaglandin-D synthase activity|retinoid binding|fatty acid binding|protein binding|extracellular region|extracellular space|endoplasmic reticulum membrane|rough endoplasmic reticulum|Golgi apparatus|gene expression|cyclooxygenase pathway|nuclear membrane|mast cell degranulation|regulation of circadian sleep/wake cycle, sleep|perinuclear region of cytoplasm|response to glucocorticoid|extracellular exosome|negative regulation of male germ cell proliferation","WP167,WP98,WP5122,WP4814,WP3591,WP4719,WP3594,WP4842,WP5321","Eicosanoid synthesis|Prostaglandin synthesis and regulation|Prostaglandin and leukotriene metabolism in senescence |Somatic sex determination|Sleep regulation|Eicosanoid metabolism via cyclooxygenases (COX)|Circadian rhythm genes|Mammalian disorder of sexual development|Prostaglandin and leukotriene metabolism in senescence ","R-HSA-1266738,R-HSA-1430728,R-HSA-2142753,R-HSA-2162123,R-HSA-556833,R-HSA-8978868,R-HSA-9690406","Developmental Biology|Metabolism|Arachidonic acid metabolism|Synthesis of Prostaglandins (PG) and Thromboxanes (TX)|Metabolism of lipids|Fatty acid metabolism|Transcriptional regulation of testis differentiation"]
["PTOV1-AS1",0.602093220703429,0.238621061517659,0.188422222020659,0.300751271358571,0.428998026390632,0.176686317941219,0.198952252907779,0.430507827687912,0.378515101354372,0.386595295961955,0.294913471568408,0.517416417356932,0.167004050002023,0.346805062848438,0.256640691628544,0.285437916208248,0.265318240122219,0.0580307970461265,0.231861414764291,0.313617205370757,0.130232373293706,0.405387523279993,0.359115795673141,0.306369058372203,0.348208699856806,0.274129743535098,0.315593715341339,0.212263984473864,100506033,"PTOV1 antisense RNA 1","non_coding"]
["PTPN13",17.9479121014916,20.080031428142,19.0252998287412,13.6405071988476,20.4944974211195,19.7626979227251,19.8070435183766,16.0044289471722,21.5519883940923,17.1087072593012,15.0319183088159,19.1880150656654,24.4770425077707,20.7220987681857,26.5268732613727,25.7865505117166,18.6277708803983,16.150092485657,15.811550550328,20.2677239252192,19.2094663712907,16.2202036264551,22.1543406627642,22.3941607709474,20.0878767457674,14.2173877384676,19.3258287953272,14.3985080467805,5783,"protein tyrosine phosphatase non-receptor type 13","protein_coding","hsa04210","Apoptosis","GO:0001650,GO:0001933,GO:0004725,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005856,GO:0005886,GO:0006470,GO:0030027,GO:0035335,GO:0036312,GO:0044297,GO:0051896,GO:0070062,GO:0097237,GO:1904890","fibrillar center|negative regulation of protein phosphorylation|protein tyrosine phosphatase activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|cytoskeleton|plasma membrane|protein dephosphorylation|lamellipodium|peptidyl-tyrosine dephosphorylation|phosphatidylinositol 3-kinase regulatory subunit binding|cell body|regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction|extracellular exosome|cellular response to toxic substance|negative regulation of excitatory synapse assembly","WP2858,WP1772","Ectoderm differentiation|Apoptosis modulation and signaling","R-HSA-1280215,R-HSA-1430728,R-HSA-1483255,R-HSA-1483257,R-HSA-162582,R-HSA-1660499,R-HSA-168256,R-HSA-194315,R-HSA-446652,R-HSA-449147,R-HSA-556833,R-HSA-9008059,R-HSA-9012999,R-HSA-9696264,R-HSA-9696270,R-HSA-9696273,R-HSA-9716542","Cytokine Signaling in Immune system|Metabolism|PI Metabolism|Phospholipid metabolism|Signal Transduction|Synthesis of PIPs at the plasma membrane|Immune System|Signaling by Rho GTPases|Interleukin-1 family signaling|Signaling by Interleukins|Metabolism of lipids|Interleukin-37 signaling|RHO GTPase cycle|RND3 GTPase cycle|RND2 GTPase cycle|RND1 GTPase cycle|Signaling by Rho GTPases, Miro GTPases and RHOBTB3"]
["PTPRK-AS1",0.593096044779826,0.141033185148913,0.0835229692909237,0.227525450261674,0.782390460011431,0.250626334822231,0.318178120897975,0.30533376953839,0.715889067380018,0.128526189823985,0.0976101947811565,0.805550263873495,0.380719628841246,0.197905563538145,0.165472801173039,0.463934742935009,0.228090368245884,0.0548770881637518,0.0959266023734664,0.199616807158851,0.209923019958127,0.169127895074491,0.161017000377781,0.246261403949652,0.441006892970459,0.0563547920655213,0.114785629900742,0.209092089583028,101928140,"PTPRK antisense RNA 1","non_coding"]
["PUS7",4.25824556607507,4.96161508581375,4.43326726958761,3.97451501011582,3.93063844738606,4.20578562263462,4.31343934342125,3.31812845582985,3.46481726020853,3.12719265926038,3.31097399532226,3.38906774391084,3.51443417043749,3.39276250638281,4.19351021748527,4.00862460688679,5.0736916941623,4.54507679111274,4.68050691253534,5.72543476304216,4.81580580612092,5.00892895343394,6.19313624866304,5.05908738490166,5.15653374228004,4.22672863225979,5.14342427138666,4.40356787999922,54517,"pseudouridine synthase 7","protein_coding",null,null,"GO:0001522,GO:0003723,GO:0005634,GO:0006397,GO:0008380,GO:0009982,GO:0017148,GO:0019899,GO:0031119,GO:1902036,GO:1990481,GO:2000380","pseudouridine synthesis|RNA binding|nucleus|mRNA processing|RNA splicing|pseudouridine synthase activity|negative regulation of translation|enzyme binding|tRNA pseudouridine synthesis|regulation of hematopoietic stem cell differentiation|mRNA pseudouridine synthesis|regulation of mesoderm development",null,null,"R-HSA-6782315,R-HSA-72306,R-HSA-8953854","tRNA modification in the nucleus and cytosol|tRNA processing|Metabolism of RNA"]
["PXMP2",14.5341242969403,14.802377849114,12.1058363902572,15.0051568433075,9.91162347364997,11.2474381248933,13.9231950415321,13.4073452217099,13.4732905585801,16.0056181711115,16.1251754266851,14.4827418231386,12.7382769561852,12.2403570916572,14.9897887000773,11.8043782089915,19.8784283096931,21.1618215437731,23.7320436403865,19.9356335154223,18.7016739417459,23.4832338724384,23.3195473930445,21.7199870166388,21.4075657358615,22.3653868925064,21.5403222168556,21.0573410036239,5827,"peroxisomal membrane protein 2","protein_coding","hsa04146","Peroxisome","GO:0005515,GO:0005737,GO:0005778,GO:0005829,GO:0008150,GO:0016020,GO:0032991","protein binding|cytoplasm|peroxisomal membrane|cytosol|biological_process|membrane|protein-containing complex","WP5166","Glyoxylate metabolism","R-HSA-1430728,R-HSA-389661,R-HSA-71291,R-HSA-9603798,R-HSA-9609507","Metabolism|Glyoxylate metabolism and glycine degradation|Metabolism of amino acids and derivatives|Class I peroxisomal membrane protein import|Protein localization"]
["PYCR3",3.45220231019869,3.22991314131973,3.56667071107588,3.70538165110285,2.83739448693553,3.21149675715955,3.52188980218691,3.32985309426568,3.36697601652081,4.3814278139638,4.39200814101609,3.53000706595671,2.90715473217914,3.39122019962267,2.74545222987548,2.43196606391164,4.31170648088505,4.23903338479997,4.64425975979402,4.28149637062848,4.21760598159319,4.98350373053876,4.04510866103306,4.16860298393472,3.45458038673018,4.62908581934254,4.13676488010778,4.36015192191539,65263,"pyrroline-5-carboxylate reductase 3","protein_coding","hsa00330","Arginine and proline metabolism","GO:0004735,GO:0005515,GO:0005829,GO:0045171,GO:0055129,GO:0072686","pyrroline-5-carboxylate reductase activity|protein binding|cytosol|intercellular bridge|L-proline biosynthetic process|mitotic spindle","WP497","Urea cycle and metabolism of amino groups","R-HSA-1430728,R-HSA-71291,R-HSA-8964539","Metabolism|Metabolism of amino acids and derivatives|Glutamate and glutamine metabolism"]
["RAB11B",44.1132528566683,58.9716160381668,56.3130769820379,64.9728973753378,48.6553372927486,60.2742148851156,54.3174686055103,59.0673526685499,57.1446629112817,92.1579664805333,86.7027948698859,65.9412975542197,55.204186551109,70.7785509995317,61.3484166092396,61.7424727646485,51.4749393926679,63.4207777699554,71.3717192262939,60.2556514650976,60.7103711017619,70.0519763667643,51.9179570350185,53.2838068282636,59.3665173370332,72.8286269087276,52.2685028819439,74.7348781988957,9230,"RAB11B%2C member RAS oncogene family","protein_coding","hsa04152,hsa04144,hsa04962,hsa05164","AMPK signaling pathway|Endocytosis|Vasopressin-regulated water reabsorption|Influenza A","GO:0001881,GO:0003924,GO:0003925,GO:0005515,GO:0005525,GO:0005794,GO:0005829,GO:0008021,GO:0019003,GO:0030670,GO:0030672,GO:0031489,GO:0032402,GO:0032456,GO:0033572,GO:0035773,GO:0044070,GO:0045054,GO:0045055,GO:0045296,GO:0045335,GO:0055037,GO:0055038,GO:0070062,GO:0071468,GO:0090150,GO:0150093,GO:2000008,GO:2001135","receptor recycling|GTPase activity|G protein activity|protein binding|GTP binding|Golgi apparatus|cytosol|synaptic vesicle|GDP binding|phagocytic vesicle membrane|synaptic vesicle membrane|myosin V binding|melanosome transport|endocytic recycling|transferrin transport|insulin secretion involved in cellular response to glucose stimulus|regulation of monoatomic anion transport|constitutive secretory pathway|regulated exocytosis|cadherin binding|phagocytic vesicle|recycling endosome|recycling endosome membrane|extracellular exosome|cellular response to acidic pH|establishment of protein localization to membrane|amyloid-beta clearance by transcytosis|regulation of protein localization to cell surface|regulation of endocytic recycling","WP4856,WP3932,WP5085","Intracellular trafficking proteins involved in CMT neuropathy|Focal adhesion: PI3K-Akt-mTOR-signaling pathway|Vasopressin-regulated water reabsorption","R-HSA-199991,R-HSA-392499,R-HSA-5653656,R-HSA-597592,R-HSA-8854214,R-HSA-8873719,R-HSA-9007101","Membrane Trafficking|Metabolism of proteins|Vesicle-mediated transport|Post-translational protein modification|TBC/RABGAPs|RAB geranylgeranylation|Rab regulation of trafficking"]
["RAB28",7.37016003202556,6.52725567137476,6.17022564149779,5.42653709447432,5.99678285308008,5.73567404896453,6.02352416314108,6.71499529206558,5.93946149612293,4.73693026198432,5.55315400458573,6.65597828363073,5.44987785885235,5.49121747122107,5.34304372097704,5.41985101096656,8.31345198212884,7.10125174690792,7.76368230382615,7.14310771845201,8.57218053382511,7.03318988855252,8.86579867106043,8.81629236182647,7.91106552352283,7.36139779261476,10.3469700479405,7.86992015369008,9364,"RAB28%2C member RAS oncogene family","protein_coding",null,null,"GO:0003924,GO:0005515,GO:0005525,GO:0005737,GO:0005886,GO:0006886,GO:0012505,GO:0019003,GO:0035253,GO:0036064","GTPase activity|protein binding|GTP binding|cytoplasm|plasma membrane|intracellular protein transport|endomembrane system|GDP binding|ciliary rootlet|ciliary basal body","WP4803","Ciliopathies"]
["RAB35",20.0965519622925,20.8933091546564,20.3252304934201,21.9703547119971,21.2948334087619,20.8183157499805,20.6769356330854,20.2388278908455,21.2380173081873,25.3959987765293,23.0042569188999,22.0237802568187,20.1869414534884,20.7191044011485,20.5965050648009,19.4977138272418,23.4381510093203,22.8213184727156,25.3663552373592,23.6238022390701,24.6458078706812,23.0577223998829,23.3224627200643,23.529606320825,22.644520042911,24.9113238009969,24.7428514171279,24.9521939562436,11021,"RAB35%2C member RAS oncogene family","protein_coding","hsa04144","Endocytosis","GO:0000281,GO:0003924,GO:0005515,GO:0005525,GO:0005546,GO:0005829,GO:0005886,GO:0005905,GO:0008104,GO:0010008,GO:0015031,GO:0016197,GO:0019003,GO:0019882,GO:0030669,GO:0031175,GO:0031253,GO:0032456,GO:0032482,GO:0036010,GO:0042470,GO:0045171,GO:0045334,GO:0048227,GO:0055038,GO:0070062,GO:1990090","mitotic cytokinesis|GTPase activity|protein binding|GTP binding|phosphatidylinositol-4,5-bisphosphate binding|cytosol|plasma membrane|clathrin-coated pit|protein localization|endosome membrane|protein transport|endosomal transport|GDP binding|antigen processing and presentation|clathrin-coated endocytic vesicle membrane|neuron projection development|cell projection membrane|endocytic recycling|Rab protein signal transduction|protein localization to endosome|melanosome|intercellular bridge|clathrin-coated endocytic vesicle|plasma membrane to endosome transport|recycling endosome membrane|extracellular exosome|cellular response to nerve growth factor stimulus","WP5199","PtdIns(4,5)P2 in cytokinesis pathway","R-HSA-199991,R-HSA-392499,R-HSA-5653656,R-HSA-597592,R-HSA-8854214,R-HSA-8873719,R-HSA-8876198,R-HSA-9007101","Membrane Trafficking|Metabolism of proteins|Vesicle-mediated transport|Post-translational protein modification|TBC/RABGAPs|RAB geranylgeranylation|RAB GEFs exchange GTP for GDP on RABs|Rab regulation of trafficking"]
["RAB5IF",12.0879888947278,10.0719702962437,9.19239567402305,11.9872497675812,10.5834390237958,8.19559353717792,10.4434136251096,9.95689314835505,9.87300911333577,8.6618583032588,10.3904020101536,9.31572521895917,10.0241372649644,8.73550846894172,8.49877211190714,9.35237972451653,12.8770309622726,11.2740671134478,14.7246658671056,11.2520963498244,14.5582273292144,11.21431707502,11.5277669734796,12.8488820055381,12.3678108882772,12.8640553152614,15.5808366879215,13.705114473767,55969,"RAB5 interacting factor","protein_coding",null,null,"GO:0003674,GO:0005515,GO:0005746,GO:0005789,GO:0097250,GO:0160063,GO:0160064","molecular_function|protein binding|mitochondrial respirasome|endoplasmic reticulum membrane|mitochondrial respirasome assembly|multi-pass transmembrane protein insertion into ER membrane|multi-pass translocon complex"]
["RABL2B",3.83811687187631,4.54068235266816,4.78956124232772,4.19539977800383,4.47840553015165,4.42688227178485,4.92099629965086,4.83897270691826,4.52604362423142,4.47150656164552,4.20364172275376,3.95740147319678,3.83705004956561,3.99440948015194,4.33984707113669,4.71277058304676,3.73595684190669,4.29020412376537,4.31290682287404,4.06906576457633,3.63948872479427,4.2544284664919,3.7949499490079,4.15149243327923,4.26607623027086,4.81911967669828,3.97359909310552,3.85480197769944,11158,"RAB%2C member of RAS oncogene family like 2B","protein_coding",null,null,"GO:0000242,GO:0003924,GO:0005515,GO:0005525,GO:0005737,GO:0005814,GO:0006886,GO:0012505,GO:0036064,GO:0042073,GO:0060271","pericentriolar material|GTPase activity|protein binding|GTP binding|cytoplasm|centriole|intracellular protein transport|endomembrane system|ciliary basal body|intraciliary transport|cilium assembly","WP4906","3q29 copy number variation syndrome"]
["RAET1E",0.0557464899911966,0.0185584563561687,0.0104673600228104,0.0294052706179103,0.0381311863804557,0.0104697589978473,0.00520109717346364,0.013666208572039,0,0.00805365226277895,0.00524263509792583,0.00560856006970827,0.0079521626539067,0.0106294906572624,0.00518439238500993,0.0105712281034626,0.0348379676553822,0.0103160527641092,0.0386415712176969,0.013401751754686,0.0289390311455046,0.0158967280139295,0.01926192033171,0.0299545369490663,0.0138170911560386,0.00794537886271723,0.0269724272515187,0.0314448904032216,135250,"retinoic acid early transcript 1E","protein_coding","hsa04650","Natural killer cell mediated cytotoxicity","GO:0001916,GO:0002476,GO:0002486,GO:0005515,GO:0005615,GO:0005886,GO:0006955,GO:0009897,GO:0042267,GO:0045954,GO:0046703","positive regulation of T cell mediated cytotoxicity|antigen processing and presentation of endogenous peptide antigen via MHC class Ib|antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent|protein binding|extracellular space|plasma membrane|immune response|external side of plasma membrane|natural killer cell mediated cytotoxicity|positive regulation of natural killer cell mediated cytotoxicity|natural killer cell lectin-like receptor binding",null,null,"R-HSA-1280218,R-HSA-168256,R-HSA-198933","Adaptive Immune System|Immune System|Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"]
["RAN",149.362825939338,123.442790471827,133.029212049722,135.201496164447,119.801460374018,120.100412066742,130.615486865815,126.668567710369,121.493669799613,105.175495775811,115.428632701205,123.111916046277,110.862613158154,102.667444612141,111.548542712943,96.5021856855137,170.787745672528,151.791546910663,184.396073256337,150.805879345117,154.923736354367,160.505038028386,190.582331013551,178.680535583048,159.410857473095,165.910774283619,206.969626164809,169.139227653524,5901,"RAN%2C member RAS oncogene family","protein_coding","hsa03013,hsa03008,hsa03250,hsa05166","Nucleocytoplasmic transport|Ribosome biogenesis in eukaryotes|Viral life cycle - HIV-1|Human T-cell leukemia virus 1 infection","GO:0000054,GO:0000055,GO:0000056,GO:0000070,GO:0000278,GO:0000287,GO:0000785,GO:0001673,GO:0002177,GO:0003682,GO:0003723,GO:0003924,GO:0003925,GO:0005049,GO:0005515,GO:0005525,GO:0005634,GO:0005635,GO:0005643,GO:0005654,GO:0005730,GO:0005737,GO:0005814,GO:0005829,GO:0006259,GO:0006606,GO:0006611,GO:0007052,GO:0007286,GO:0016020,GO:0016032,GO:0019003,GO:0019904,GO:0021766,GO:0030036,GO:0030496,GO:0032092,GO:0032991,GO:0035281,GO:0036126,GO:0042307,GO:0042470,GO:0042565,GO:0045296,GO:0045505,GO:0046039,GO:0046982,GO:0051301,GO:0055037,GO:0061015,GO:0061676,GO:0070062,GO:0070883,GO:0071389,GO:0090543,GO:1902570","ribosomal subunit export from nucleus|ribosomal large subunit export from nucleus|ribosomal small subunit export from nucleus|mitotic sister chromatid segregation|mitotic cell cycle|magnesium ion binding|chromatin|male germ cell nucleus|manchette|chromatin binding|RNA binding|GTPase activity|G protein activity|nuclear export signal receptor activity|protein binding|GTP binding|nucleus|nuclear envelope|nuclear pore|nucleoplasm|nucleolus|cytoplasm|centriole|cytosol|DNA metabolic process|protein import into nucleus|protein export from nucleus|mitotic spindle organization|spermatid development|membrane|viral process|GDP binding|protein domain specific binding|hippocampus development|actin cytoskeleton organization|midbody|positive regulation of protein binding|protein-containing complex|pre-miRNA export from nucleus|sperm flagellum|positive regulation of protein import into nucleus|melanosome|RNA nuclear export complex|cadherin binding|dynein intermediate chain binding|GTP metabolic process|protein heterodimerization activity|cell division|recycling endosome|snRNA import into nucleus|importin-alpha family protein binding|extracellular exosome|pre-miRNA binding|cellular response to mineralocorticoid stimulus|Flemming body|protein localization to nucleolus","WP138,WP4657,WP2338","Androgen receptor signaling pathway|22q11.2 copy number variation syndrome|miRNA biogenesis","R-HSA-1430728,R-HSA-162587,R-HSA-162599,R-HSA-162906,R-HSA-162909,R-HSA-1640170,R-HSA-1640170,R-HSA-1643685,R-HSA-165054,R-HSA-1655829,R-HSA-168255,R-HSA-168274,R-HSA-168333,R-HSA-177243,R-HSA-180746,R-HSA-203927,R-HSA-211000,R-HSA-2555396,R-HSA-2555396,R-HSA-2995410,R-HSA-2995410,R-HSA-556833,R-HSA-5578749,R-HSA-5663205,R-HSA-6784531,R-HSA-68882,R-HSA-68882,R-HSA-68886,R-HSA-68886,R-HSA-69278,R-HSA-69278,R-HSA-72306,R-HSA-74160,R-HSA-8953854,R-HSA-8957322,R-HSA-9615933,R-HSA-9615933,R-HSA-9824446","Metabolism|HIV Life Cycle|Late Phase of HIV Life Cycle|HIV Infection|Host Interactions of HIV factors|Cell Cycle|Cell Cycle|Disease|Rev-mediated nuclear export of HIV RNA|Regulation of cholesterol biosynthesis by SREBP (SREBF)|Influenza Infection|Export of Viral Ribonucleoproteins from Nucleus|NEP/NS2 Interacts with the Cellular Export Machinery|Interactions of Rev with host cellular proteins|Nuclear import of Rev protein|MicroRNA (miRNA) biogenesis|Gene Silencing by RNA|Mitotic Metaphase and Anaphase|Mitotic Metaphase and Anaphase|Nuclear Envelope (NE) Reassembly|Nuclear Envelope (NE) Reassembly|Metabolism of lipids|Transcriptional regulation by small RNAs|Infectious disease|tRNA processing in the nucleus|Mitotic Anaphase|Mitotic Anaphase|M Phase|M Phase|Cell Cycle, Mitotic|Cell Cycle, Mitotic|tRNA processing|Gene expression (Transcription)|Metabolism of RNA|Metabolism of steroids|Postmitotic nuclear pore complex (NPC) reformation|Postmitotic nuclear pore complex (NPC) reformation|Viral Infection Pathways"]
["RANBP3",16.8379575349379,17.8492117569258,18.8534033455539,19.6233104689409,15.9994579853859,17.454663073155,16.5547338128069,17.5816330603123,17.2403953812229,21.9657976320319,21.6158565265837,19.1056379978413,15.3207031034811,17.8538116190484,17.1351315103282,15.8915394335362,16.7022480178949,18.1510933571101,19.7762604599062,19.4077510373013,18.873755502264,18.7572404332421,15.7744364106722,15.9283543499892,16.9084474508798,19.6402600497964,15.2374956804467,22.1687576077634,8498,"RAN binding protein 3","protein_coding","hsa05166","Human T-cell leukemia virus 1 infection","GO:0005096,GO:0005515,GO:0005634,GO:0005643,GO:0005654,GO:0005737,GO:0006611,GO:0070412","GTPase activator activity|protein binding|nucleus|nuclear pore|nucleoplasm|cytoplasm|protein export from nucleus|R-SMAD binding"]
["RARS2",11.1854570792379,10.3972802053882,11.7833342260755,11.2731882856185,11.7802836740782,11.1763039371012,11.9472979876603,11.5854392337637,12.3620193474063,9.50940607351787,10.821445221142,11.3410488436933,11.5921421829502,11.4042510559716,12.4629741778461,12.7634263592034,13.0903169354365,11.9722332978971,12.9733370765928,12.7130108720461,13.697469232935,12.3819510548712,15.1330608463956,14.0015574362258,13.2795531278206,13.229591812034,15.3258483681244,12.4224066357665,57038,"arginyl-tRNA synthetase 2%2C mitochondrial","protein_coding","hsa00970","Aminoacyl-tRNA biosynthesis","GO:0003723,GO:0004814,GO:0005515,GO:0005524,GO:0005739,GO:0005759,GO:0006418,GO:0006420,GO:0032543","RNA binding|arginine-tRNA ligase activity|protein binding|ATP binding|mitochondrion|mitochondrial matrix|tRNA aminoacylation for protein translation|arginyl-tRNA aminoacylation|mitochondrial translation",null,null,"R-HSA-379724,R-HSA-379726,R-HSA-392499,R-HSA-72766","tRNA Aminoacylation|Mitochondrial tRNA aminoacylation|Metabolism of proteins|Translation"]
["RASIP1",0.193808362116471,0.240448575117904,0.158221067178179,0.299013889834749,0.345826855409866,0.189908795126317,0.165097847148469,0.264414435711538,0.466172683177868,0.397671843350362,0.459626194726221,0.373019211488362,0.12020219603928,0.289209202037345,0.297788970413626,0.327571758872467,0.202538043856975,0.32746131164672,0.381607359113702,0.194473284730831,0.30222615214728,0.376453634535141,0.324431707658229,0.238739932314024,0.208854467911924,0.352292320014472,0.163082428227219,0.245576992491827,54922,"Ras interacting protein 1","protein_coding","hsa04520","Adherens junction","GO:0001525,GO:0001570,GO:0005515,GO:0005795,GO:0005911,GO:0007165,GO:0010507,GO:0032991,GO:0033625,GO:0035024,GO:0042803,GO:0043087,GO:0048471,GO:0048754,GO:0051020,GO:1905709,GO:2000299","angiogenesis|vasculogenesis|protein binding|Golgi stack|cell-cell junction|signal transduction|negative regulation of autophagy|protein-containing complex|positive regulation of integrin activation|negative regulation of Rho protein signal transduction|protein homodimerization activity|regulation of GTPase activity|perinuclear region of cytoplasm|branching morphogenesis of an epithelial tube|GTPase binding|negative regulation of membrane permeability|negative regulation of Rho-dependent protein serine/threonine kinase activity"]
["RBFA",3.23571027242363,3.34372778189497,3.80290986474524,4.01894300528068,3.12881537329795,3.56378094383089,3.47779550277372,3.93424083647074,3.23043340829948,3.60871191370909,3.68697129141763,3.05162806879065,2.61395695079195,2.86417853234338,3.05403883832276,2.63358604049313,3.66729222910973,4.21196868022923,3.8283907415219,3.35729656683248,3.87329377211184,4.06574080573483,3.2514854979198,3.82547642526507,3.81034689053056,4.16959932456874,3.48111550243793,4.50171154358869,79863,"ribosome binding factor A","protein_coding",null,null,"GO:0003674,GO:0005515,GO:0005575,GO:0005739,GO:0006364,GO:0008150","molecular_function|protein binding|cellular_component|mitochondrion|rRNA processing|biological_process"]
["RBL2",12.3271399159493,11.4532538004156,10.7868632858769,8.79228184833051,13.9763805759511,11.571103138694,10.8226476556691,10.2290261748239,13.8472091501702,11.5151814290524,10.0176778645632,12.064070621586,15.8436975265826,12.0584214910318,15.5032160095863,13.7184228400965,12.8209649035283,10.1854683296899,10.6513941804168,13.4165732194545,12.4870257692882,11.0786165702692,14.5213341786452,13.7630465636851,13.3550507125266,9.53051274187142,12.787733140591,10.377238460963,5934,"RB transcriptional corepressor like 2","protein_coding","hsa04068,hsa04151,hsa04110,hsa04218,hsa05203,hsa05165","FoxO signaling pathway|PI3K-Akt signaling pathway|Cell cycle|Cellular senescence|Viral carcinogenesis|Human papillomavirus infection","GO:0000785,GO:0000977,GO:0005515,GO:0005654,GO:0005667,GO:0005694,GO:0005730,GO:0005829,GO:0006325,GO:0006357,GO:0007049,GO:0010629,GO:0030154,GO:0043550,GO:0070062,GO:1990841,GO:2000134","chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|protein binding|nucleoplasm|transcription regulator complex|chromosome|nucleolus|cytosol|chromatin organization|regulation of transcription by RNA polymerase II|cell cycle|negative regulation of gene expression|cell differentiation|regulation of lipid kinase activity|extracellular exosome|promoter-specific chromatin binding|negative regulation of G1/S transition of mitotic cell cycle","WP2032,WP179,WP236,WP5180,WP710,WP53,WP727,WP4172","Thyroid stimulating hormone (TSH) signaling pathway|Cell cycle|Adipogenesis|DYRK1A involvement regarding cell proliferation in brain development|DNA damage response (only ATM dependent)|ID signaling pathway|Monoamine transport|PI3K-Akt signaling pathway","R-HSA-1362277,R-HSA-1362277,R-HSA-1362300,R-HSA-1538133,R-HSA-1538133,R-HSA-1640170,R-HSA-1640170,R-HSA-212436,R-HSA-212436,R-HSA-3700989,R-HSA-453279,R-HSA-453279,R-HSA-6791312,R-HSA-6804114,R-HSA-69202,R-HSA-69205,R-HSA-69205,R-HSA-69206,R-HSA-69206,R-HSA-69231,R-HSA-69236,R-HSA-69242,R-HSA-69278,R-HSA-69278,R-HSA-69656,R-HSA-73857,R-HSA-73857,R-HSA-74160,R-HSA-74160,R-HSA-9614085,R-HSA-9617828","Transcription of E2F targets under negative control by DREAM complex|Transcription of E2F targets under negative control by DREAM complex|Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1|G0 and Early G1|G0 and Early G1|Cell Cycle|Cell Cycle|Generic Transcription Pathway|Generic Transcription Pathway|Transcriptional Regulation by TP53|Mitotic G1 phase and G1/S transition|Mitotic G1 phase and G1/S transition|TP53 Regulates Transcription of Cell Cycle Genes|TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest|Cyclin E associated events during G1/S transition |G1/S-Specific Transcription|G1/S-Specific Transcription|G1/S Transition|G1/S Transition|Cyclin D associated events in G1|G1 Phase|S Phase|Cell Cycle, Mitotic|Cell Cycle, Mitotic|Cyclin A:Cdk2-associated events at S phase entry|RNA Polymerase II Transcription|RNA Polymerase II Transcription|Gene expression (Transcription)|Gene expression (Transcription)|FOXO-mediated transcription|FOXO-mediated transcription of cell cycle genes","other"]
["RBM34",21.5132714024476,19.8206700959857,23.4198494887988,22.7673487265474,21.0779963709206,18.7185959648689,21.9207486443344,22.363287599691,21.4227515009419,15.3118036288229,22.0958160139634,21.2973699136748,22.6987598424966,19.6613807610827,20.2876971362545,18.8046927532284,24.8950095203864,21.8189489870208,28.0592211298446,23.2148771007027,27.8012339951066,24.9812803782245,34.040882692644,30.6288556923301,28.0491661676075,26.0908576047449,35.4100520182828,26.7595989410185,23029,"RNA binding motif protein 34","protein_coding",null,null,"GO:0000463,GO:0003723,GO:0005654,GO:0005694,GO:0005730,GO:0019843","maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|RNA binding|nucleoplasm|chromosome|nucleolus|rRNA binding"]
["RBPMS",8.05765995153462,9.87640612978384,9.94327812066325,10.7480048330316,8.60939289469307,10.0248571054582,9.07051149605132,10.2613600266274,10.4337490879584,14.2028402080106,14.2356060818326,12.5706569067786,11.0223326978818,14.2234267582781,12.3038671792468,13.4215108319765,7.5135285122302,9.69210965541781,9.30394847878692,8.70935570549981,9.14288873020501,9.53876029865502,7.99984184475935,7.89617639210005,8.40716521221299,10.0901706742235,8.28074711506374,10.2479305541862,11030,"RNA binding protein%2C mRNA processing factor","protein_coding",null,null,"GO:0000932,GO:0003713,GO:0003723,GO:0003729,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006396,GO:0006979,GO:0008143,GO:0010494,GO:0042803,GO:0045893,GO:0060395","P-body|transcription coactivator activity|RNA binding|mRNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|RNA processing|response to oxidative stress|poly(A) binding|cytoplasmic stress granule|protein homodimerization activity|positive regulation of DNA-templated transcription|SMAD protein signal transduction","WP410","Exercise-induced circadian regulation"]
["RCOR1",7.26050728558365,7.02632184014507,5.65028312442574,5.32695295668398,7.02137959166231,6.02130749951627,5.61073354294378,5.46497161488871,6.29413813251074,5.17801200227412,4.79156291278284,6.0550037918142,6.41880980915444,5.52777272339935,6.57350845098156,6.00411244920804,5.87645028549607,6.13674417443082,4.71324948876167,6.33280192709074,5.76452774033373,6.28208229983263,6.06178953477998,6.06755636261847,6.41288896632474,4.94806539316449,5.37031485369735,4.88684316371527,23186,"REST corepressor 1","protein_coding","hsa05016","Huntington disease","GO:0000118,GO:0003682,GO:0003714,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0006325,GO:0006357,GO:0010629,GO:0017053,GO:0019899,GO:0030218,GO:0045654,GO:0045892,GO:1990391","histone deacetylase complex|chromatin binding|transcription corepressor activity|protein binding|nucleus|nucleoplasm|transcription regulator complex|chromatin organization|regulation of transcription by RNA polymerase II|negative regulation of gene expression|transcription repressor complex|enzyme binding|erythrocyte differentiation|positive regulation of megakaryocyte differentiation|negative regulation of DNA-templated transcription|DNA repair complex",null,null,"R-HSA-109582,R-HSA-1257604,R-HSA-162582,R-HSA-1643685,R-HSA-3214815,R-HSA-3247509,R-HSA-4839726,R-HSA-5663205,R-HSA-6807070,R-HSA-8943724,R-HSA-9006925,R-HSA-9679191,R-HSA-9679506,R-HSA-9824446,R-HSA-983231","Hemostasis|PIP3 activates AKT signaling|Signal Transduction|Disease|HDACs deacetylate histones|Chromatin modifying enzymes|Chromatin organization|Infectious disease|PTEN Regulation|Regulation of PTEN gene transcription|Intracellular signaling by second messengers|Potential therapeutics for SARS|SARS-CoV Infections|Viral Infection Pathways|Factors involved in megakaryocyte development and platelet production","MYB"]
["RDH12",0,0,0.0539030025455801,0.0275320333184055,0,0,0.0133918559011094,0,0.0144378585873366,0.0138244357531656,0,0.0144409969206998,0,0,0,0,0,0,0,0,0,0,0,0,0.014230573862625,0,0,0,145226,"retinol dehydrogenase 12","protein_coding","hsa00830","Retinol metabolism","GO:0001523,GO:0001917,GO:0004745,GO:0005515,GO:0005789,GO:0007601,GO:0042572,GO:0045494,GO:0052650,GO:0060342,GO:0102354,GO:0110095","retinoid metabolic process|photoreceptor inner segment|NAD-retinol dehydrogenase activity|protein binding|endoplasmic reticulum membrane|visual perception|retinol metabolic process|photoreceptor cell maintenance|NADP-retinol dehydrogenase activity|photoreceptor inner segment membrane|11-cis-retinol dehydrogenase activity|cellular detoxification of aldehyde","WP5188,WP716","Retinol metabolism|Vitamin A and carotenoid metabolism","R-HSA-1643685,R-HSA-2187338,R-HSA-2453864,R-HSA-2453902,R-HSA-2474795,R-HSA-9675143,R-HSA-9709957","Disease|Visual phototransduction|Retinoid cycle disease events|The canonical retinoid cycle in rods (twilight vision)|Diseases associated with visual transduction|Diseases of the neuronal system|Sensory Perception"]
["REP15",0.281282245932971,0.802638252315314,0.572168653977301,0.741856622989071,0.939095331857199,0.176092242205533,0.437389658822321,0.666575859113997,0.165043555642719,0.180607237178748,0.418838676786423,0.330158861773079,0.445828203048879,0.536336369459402,0.196193186434295,0.222248580409973,0.766234882718184,0.45545597215559,0.584925863863847,0.38318987838829,0.398233095948391,0.512457522075709,0.532234375794193,0.27480505312356,0.650696083471544,0.267268726891611,0.340239579064484,0.220364880499678,387849,"RAB15 effector protein","protein_coding",null,null,"GO:0001881,GO:0005515,GO:0010008,GO:0031901,GO:0033572,GO:0048471,GO:0055037","receptor recycling|protein binding|endosome membrane|early endosome membrane|transferrin transport|perinuclear region of cytoplasm|recycling endosome"]
["RFC2",12.8781049983789,11.511477709381,7.4603423531305,11.8736601932363,10.0814536201798,9.39971211447287,7.61870097899792,9.6720758620551,10.8781034405898,11.7408185976779,10.0329563027572,10.8362983017191,8.6424595876047,6.45974257868844,6.27408721125236,6.17457714575481,15.0548001402683,15.585137726688,14.1068349099507,13.6503899004323,16.0363408751204,16.3029374558287,11.9622709869053,14.7690310739293,13.5221045111059,14.9063014165752,12.3769381439635,15.2024251843087,5982,"replication factor C subunit 2","protein_coding","hsa03030,hsa03410,hsa03420,hsa03430","DNA replication|Base excision repair|Nucleotide excision repair|Mismatch repair","GO:0003677,GO:0003689,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005663,GO:0006261,GO:0006281,GO:0016887,GO:0017116,GO:0019899,GO:0031390,GO:0032508,GO:1900264","DNA binding|DNA clamp loader activity|protein binding|ATP binding|nucleus|nucleoplasm|DNA replication factor C complex|DNA-templated DNA replication|DNA repair|ATP hydrolysis activity|single-stranded DNA helicase activity|enzyme binding|Ctf18 RFC-like complex|DNA duplex unwinding|positive regulation of DNA-directed DNA polymerase activity","WP531,WP4932,WP466,WP5114,WP5366,WP4946,WP4753","DNA mismatch repair|7q11.23 copy number variation syndrome|DNA replication|Nucleotide excision repair in xeroderma pigmentosum |NF1 copy number variation syndrome |DNA repair pathways, full network|Nucleotide excision repair","R-HSA-110312,R-HSA-110313,R-HSA-110314,R-HSA-110320,R-HSA-110373,R-HSA-157579,R-HSA-1640170,R-HSA-1643685,R-HSA-174411,R-HSA-174417,R-HSA-176187,R-HSA-180786,R-HSA-212436,R-HSA-3700989,R-HSA-5633007,R-HSA-5651801,R-HSA-5655862,R-HSA-5656121,R-HSA-5656169,R-HSA-5685938,R-HSA-5685942,R-HSA-5693532,R-HSA-5693538,R-HSA-5693567,R-HSA-5693579,R-HSA-5693607,R-HSA-5693616,R-HSA-5696397,R-HSA-5696398,R-HSA-5696399,R-HSA-5696400,R-HSA-6781827,R-HSA-6782135,R-HSA-6782210,R-HSA-6804756,R-HSA-69091,R-HSA-69109,R-HSA-69186,R-HSA-69190,R-HSA-69239,R-HSA-69242,R-HSA-69278,R-HSA-69306,R-HSA-69473,R-HSA-69481,R-HSA-69620,R-HSA-73857,R-HSA-73884,R-HSA-73886,R-HSA-73893,R-HSA-73894,R-HSA-73933,R-HSA-74160,R-HSA-9675135,R-HSA-9675136,R-HSA-9701190,R-HSA-9709570","Translesion synthesis by REV1|Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template|Recognition of DNA damage by PCNA-containing replication complex|Translesion Synthesis by POLH|Resolution of AP sites via the multiple-nucleotide patch replacement pathway|Telomere Maintenance|Cell Cycle|Disease|Polymerase switching on the C-strand of the telomere|Telomere C-strand (Lagging Strand) Synthesis|Activation of ATR in response to replication stress|Extension of Telomeres|Generic Transcription Pathway|Transcriptional Regulation by TP53|Regulation of TP53 Activity|PCNA-Dependent Long Patch Base Excision Repair|Translesion synthesis by POLK|Translesion synthesis by POLI|Termination of translesion DNA synthesis|HDR through Single Strand Annealing (SSA)|HDR through Homologous Recombination (HRR)|DNA Double-Strand Break Repair|Homology Directed Repair|HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)|Homologous DNA Pairing and Strand Exchange|Processing of DNA double-strand break ends|Presynaptic phase of homologous DNA pairing and strand exchange|Gap-filling DNA repair synthesis and ligation in GG-NER|Nucleotide Excision Repair|Global Genome Nucleotide Excision Repair (GG-NER)|Dual Incision in GG-NER|Transcription-Coupled Nucleotide Excision Repair (TC-NER)|Dual incision in TC-NER|Gap-filling DNA repair synthesis and ligation in TC-NER|Regulation of TP53 Activity through Phosphorylation|Polymerase switching|Leading Strand Synthesis|Lagging Strand Synthesis|DNA strand elongation|Synthesis of DNA|S Phase|Cell Cycle, Mitotic|DNA Replication|G2/M DNA damage checkpoint|G2/M Checkpoints|Cell Cycle Checkpoints|RNA Polymerase II Transcription|Base Excision Repair|Chromosome Maintenance|DNA Damage Bypass|DNA Repair|Resolution of Abasic Sites (AP sites)|Gene expression (Transcription)|Diseases of DNA repair|Diseases of DNA Double-Strand Break Repair|Defective homologous recombination repair (HRR) due to BRCA2 loss of function|Impaired BRCA2 binding to RAD51"]
["RGL1",11.1034290153672,10.8977585884834,9.76459019851688,8.78003108677211,11.1225094519798,9.74810874448244,9.26673348620649,9.1189341906065,10.8878269889967,10.0268486835913,10.0343837079496,10.9353187697243,11.3270365694199,10.9373518739591,12.1151237184966,11.0475089323034,6.98109282861056,7.46542976659611,7.5491294653203,7.75876888276879,7.97288328380068,6.98245874967272,8.87057292990322,8.7931012330117,8.43401834679512,6.64836516976638,7.75944173441755,7.01835052018481,23179,"ral guanine nucleotide dissociation stimulator like 1","protein_coding","hsa04014","Ras signaling pathway","GO:0005085,GO:0005515,GO:0005575,GO:0005829,GO:0005886,GO:0007264,GO:0007265,GO:0043547","guanyl-nucleotide exchange factor activity|protein binding|cellular_component|cytosol|plasma membrane|small GTPase mediated signal transduction|Ras protein signal transduction|positive regulation of GTPase activity","WP4223","Ras signaling","R-HSA-1430728,R-HSA-162582,R-HSA-1989781,R-HSA-400206,R-HSA-556833,R-HSA-5673001,R-HSA-5683057,R-HSA-5684996","Metabolism|Signal Transduction|PPARA activates gene expression|Regulation of lipid metabolism by PPARalpha|Metabolism of lipids|RAF/MAP kinase cascade|MAPK family signaling cascades|MAPK1/MAPK3 signaling"]
["RGL2",9.57542155304557,9.51573786985046,11.6398209185097,10.3799190190755,9.18907071373564,10.1048014311607,10.9635254298817,11.048870695966,9.92962158189327,13.833537406557,13.0603723316552,11.0457710852301,10.8116885746609,13.2474462676351,13.0675646915369,11.6148509631957,9.12372194616409,10.7140093454097,11.7252760109113,10.6850961086425,9.92830831805896,10.2728684639417,10.407591496583,9.95674802568142,9.18406741227761,10.3653285907716,9.87715071535477,10.7760147666967,5863,"ral guanine nucleotide dissociation stimulator like 2","protein_coding","hsa04014","Ras signaling pathway","GO:0005085,GO:0005515,GO:0005575,GO:0005829,GO:0007265,GO:0010667,GO:0032485","guanyl-nucleotide exchange factor activity|protein binding|cellular_component|cytosol|Ras protein signal transduction|negative regulation of cardiac muscle cell apoptotic process|regulation of Ral protein signal transduction","WP4223","Ras signaling","R-HSA-162582,R-HSA-5673001,R-HSA-5683057,R-HSA-5684996","Signal Transduction|RAF/MAP kinase cascade|MAPK family signaling cascades|MAPK1/MAPK3 signaling"]
["RGS5",0.539764703505631,0.583020130671936,0.429449511202271,0.416764811160421,0.518495765003333,0.408070538370831,0.431043686341528,0.372298318592082,0.340481602511343,0.18503583819221,0.412976947825887,0.372770332527239,0.522011641105933,0.261660794535174,0.404134955181227,0.420699629131724,0.41340169703754,0.266642305097028,0.401626227144102,0.444270913394755,0.518092720561853,0.452193978413997,0.609635505958052,0.563086885536568,0.412689056842847,0.334671725864758,0.624128601677766,0.365529731356585,8490,"regulator of G protein signaling 5","protein_coding",null,null,"GO:0003924,GO:0005096,GO:0005515,GO:0005829,GO:0005886,GO:0007186,GO:0008277,GO:0009968,GO:0043231","GTPase activity|GTPase activator activity|protein binding|cytosol|plasma membrane|G protein-coupled receptor signaling pathway|regulation of G protein-coupled receptor signaling pathway|negative regulation of signal transduction|intracellular membrane-bounded organelle","WP289,WP536","Myometrial relaxation and contraction pathways|Calcium regulation in cardiac cells","R-HSA-162582,R-HSA-162582,R-HSA-372790,R-HSA-372790,R-HSA-388396,R-HSA-388396,R-HSA-416476,R-HSA-418594,R-HSA-418594","Signal Transduction|Signal Transduction|Signaling by GPCR|Signaling by GPCR|GPCR downstream signalling|GPCR downstream signalling|G alpha (q) signalling events|G alpha (i) signalling events|G alpha (i) signalling events"]
["RHOJ",0.826244145141551,1.05253830295864,0.921152747524612,0.806566513027377,1.13896980120985,1.23310351599181,0.708932746134427,1.07063785762605,2.87913185267735,2.465493910652,2.06746772872853,2.73873862290652,2.49756522069254,2.43350028972696,2.60021894749703,3.0566782727157,1.34761519908821,1.18087113483403,1.54771936144719,1.61034994290323,1.45525945100036,1.52166505597193,1.3036392072682,1.50632627527476,1.17753909467859,1.42996814743596,1.33494839404884,1.24837247573709,57381,"ras homolog family member J","protein_coding","hsa05132","Salmonella infection","GO:0001525,GO:0003924,GO:0005515,GO:0005525,GO:0005886,GO:0006897,GO:0007015,GO:0007163,GO:0008360,GO:0010594,GO:0019901,GO:0030036,GO:0032488,GO:0061299,GO:0070062,GO:0090050,GO:1903670","angiogenesis|GTPase activity|protein binding|GTP binding|plasma membrane|endocytosis|actin filament organization|establishment or maintenance of cell polarity|regulation of cell shape|regulation of endothelial cell migration|protein kinase binding|actin cytoskeleton organization|Cdc42 protein signal transduction|retina vasculature morphogenesis in camera-type eye|extracellular exosome|positive regulation of cell migration involved in sprouting angiogenesis|regulation of sprouting angiogenesis","WP5323,WP481,WP3888","Fatty Acids and Lipoproteins Transport in Hepatocytes|Insulin signaling|VEGFA-VEGFR2 signaling","R-HSA-162582,R-HSA-194315,R-HSA-9012999,R-HSA-9013409,R-HSA-9716542","Signal Transduction|Signaling by Rho GTPases|RHO GTPase cycle|RHOJ GTPase cycle|Signaling by Rho GTPases, Miro GTPases and RHOBTB3"]
["RIMBP2",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.00239305337875702,0,0.00230041634500675,0.00239350583969656,0,0,0,0,0,0,0,0,23504,"RIMS binding protein 2","protein_coding",null,null,"GO:0005886,GO:0007274,GO:0045202","plasma membrane|neuromuscular synaptic transmission|synapse"]
["RIMS4",0.00995796647035209,0.047358391318937,0.00467444767180455,0.00955026940745577,0.00486525282977186,0.0233775949547888,0.00929069278990892,0.00488237543776095,0,0.0143861970877974,0,0,0.00946993781873312,0.0427216585388561,0.00463042655665229,0,0,0,0,0,0,0,0,0,0,0,0,0,140730,"regulating synaptic membrane exocytosis 4","protein_coding",null,null,"GO:0005515,GO:0031267,GO:0042391,GO:0042734,GO:0044325,GO:0048167,GO:0048786,GO:0048788,GO:0048791,GO:0050806,GO:0097060,GO:2000300","protein binding|small GTPase binding|regulation of membrane potential|presynaptic membrane|transmembrane transporter binding|regulation of synaptic plasticity|presynaptic active zone|cytoskeleton of presynaptic active zone|calcium ion-regulated exocytosis of neurotransmitter|positive regulation of synaptic transmission|synaptic membrane|regulation of synaptic vesicle exocytosis"]
["RLF",2.81385425502302,3.28106022809291,3.34196920986101,2.90999005954467,3.54463918727392,2.66622922141493,3.16301278192529,2.43097164953971,3.54647009767004,2.17950998961384,2.6223551967523,3.04414671325123,3.86884401954066,3.37353271742775,4.05535829738551,3.59210447287365,3.2635326586453,3.51323791339427,3.76777168272269,4.55595426767734,3.76780304320505,3.69781485038123,5.03702396208307,4.41753839065222,3.95350442837341,3.55146818747264,5.13417120931766,3.13139153409306,6018,"RLF zinc finger","protein_coding",null,null,"GO:0000981,GO:0001228,GO:0003677,GO:0005515,GO:0005634,GO:0006357,GO:0044030,GO:0045893,GO:0045944,GO:0046872","DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA binding|protein binding|nucleus|regulation of transcription by RNA polymerase II|regulation of DNA methylation|positive regulation of DNA-templated transcription|positive regulation of transcription by RNA polymerase II|metal ion binding","WP4747","Netrin-UNC5B signaling pathway"]
["RND3",189.048825479514,143.9740109344,126.654504380999,136.630927576613,194.987107021295,139.957888265245,121.117356949664,134.943882538347,137.841481493961,97.6522484704849,108.330028636325,123.456293605192,140.970337791269,106.176178721556,118.683170751856,115.264036206673,183.1069985035,133.407100629983,144.235637700709,146.378469303269,202.870623570922,153.846795102671,198.976399700187,190.98151676139,191.568963813178,151.982309178621,188.393980152723,153.180283810251,390,"Rho family GTPase 3","protein_coding",null,null,"GO:0000139,GO:0003924,GO:0005515,GO:0005525,GO:0005829,GO:0005886,GO:0005925,GO:0007015,GO:0007155,GO:0007165,GO:0007264,GO:0016477,GO:0019901,GO:0030036","Golgi membrane|GTPase activity|protein binding|GTP binding|cytosol|plasma membrane|focal adhesion|actin filament organization|cell adhesion|signal transduction|small GTPase mediated signal transduction|cell migration|protein kinase binding|actin cytoskeleton organization",null,null,"R-HSA-162582,R-HSA-194315,R-HSA-9012999,R-HSA-9696264,R-HSA-9716542","Signal Transduction|Signaling by Rho GTPases|RHO GTPase cycle|RND3 GTPase cycle|Signaling by Rho GTPases, Miro GTPases and RHOBTB3"]
["RNF152",6.71421264153238,5.4466080339301,4.66968608592971,5.2086344575129,7.67605106856291,5.83844539224111,4.57969314438842,5.24209363955041,5.35146869428458,3.52452788351655,3.63641262409897,4.86421141081386,6.01527657636566,5.0776377192896,4.12142295509362,5.05788146370605,6.04315161195914,5.81314815485528,4.09321475151343,5.76856082142072,6.20860099355969,5.63730259934784,5.0252566392785,5.65540309651379,6.43989894993729,5.29259635321698,4.53019712662057,4.7854804143898,220441,"ring finger protein 152","protein_coding","hsa04150","mTOR signaling pathway","GO:0004842,GO:0005515,GO:0005764,GO:0005765,GO:0006513,GO:0006915,GO:0010508,GO:0016567,GO:0031090,GO:0031267,GO:0034198,GO:0046872,GO:0061630,GO:0070534,GO:0070936,GO:1904262","ubiquitin-protein transferase activity|protein binding|lysosome|lysosomal membrane|protein monoubiquitination|apoptotic process|positive regulation of autophagy|protein ubiquitination|organelle membrane|small GTPase binding|cellular response to amino acid starvation|metal ion binding|ubiquitin protein ligase activity|protein K63-linked ubiquitination|protein K48-linked ubiquitination|negative regulation of TORC1 signaling",null,null,"R-HSA-392499,R-HSA-597592,R-HSA-8852135,R-HSA-8866654","Metabolism of proteins|Post-translational protein modification|Protein ubiquitination|E3 ubiquitin ligases ubiquitinate target proteins"]
["RNF157",3.29424703612108,3.33386569279763,3.09841106187268,3.19980538973066,3.59857077718171,3.28291941997203,3.13250050282015,3.34548633182561,1.92029325320928,2.24762902334058,2.16353688340477,1.72682189049736,1.92435229734234,2.05836755956653,1.87346375711479,1.61311455676251,0.984327653179079,1.22590707003877,1.06867598998061,1.11481705472596,1.13116428368321,1.23935493218712,1.21286654001357,0.997288780535264,1.05383503720347,1.05577416830927,1.12184296716413,1.16348816765162,114804,"ring finger protein 157","protein_coding",null,null,"GO:0005737,GO:0016567,GO:0043066,GO:0044297,GO:0046872,GO:0061630,GO:1903861","cytoplasm|protein ubiquitination|negative regulation of apoptotic process|cell body|metal ion binding|ubiquitin protein ligase activity|positive regulation of dendrite extension"]
["RNF214",6.98240320708174,7.47251318924491,6.55533004898536,6.54951610571812,6.17881575968652,6.65759605651605,7.22961454122507,6.50871038298344,7.9176526825555,6.52563681105756,6.48004977321646,7.8422620087474,6.95362697703903,6.10151879885071,6.38667612238643,5.77012165971982,6.24154181799032,6.26909489003579,5.86533564560658,6.37538897668052,6.0984278720369,6.30918700764236,6.54510570176254,6.39479771283881,6.65655829328195,5.52028597363799,6.19306332663579,5.77165509446343,257160,"ring finger protein 214","protein_coding",null,null,"GO:0004842,GO:0046872","ubiquitin-protein transferase activity|metal ion binding"]
["RNPC3",2.20025077713038,2.24826894370039,1.90042024763019,2.14634286982506,2.92398971980018,2.44395745435092,2.72144498539634,2.25619032344539,2.42814612779267,1.57420603767624,2.06920865335987,2.09979100188169,2.04459226048419,1.96581621735158,2.24499666069094,1.41859693232765,2.59892963608526,2.16378003829248,2.90502670434038,2.74450498664572,2.36151648030134,2.11532139476213,2.3831389960934,2.4443849660808,2.15644965696068,2.21009878910876,2.50630461070822,2.31670914480539,55599,"RNA binding region (RNP1%2C RRM) containing 3","protein_coding",null,null,"GO:0000398,GO:0005634,GO:0005654,GO:0005689,GO:0008380,GO:0030626,GO:0097157","mRNA splicing, via spliceosome|nucleus|nucleoplasm|U12-type spliceosomal complex|RNA splicing|U12 snRNA binding|pre-mRNA intronic binding",null,null,"R-HSA-72165,R-HSA-72172,R-HSA-72203,R-HSA-8953854","mRNA Splicing - Minor Pathway|mRNA Splicing|Processing of Capped Intron-Containing Pre-mRNA|Metabolism of RNA"]
["RORB-AS1",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.030423700701111,0,0,0,0,0,0,0,0,0,0,0,0,0,103752585,"RORB antisense RNA 1","non_coding"]
["RPA3",7.61980143530882,6.73997591826659,7.1161569835867,7.74297547921761,6.31128304409221,5.16290249733796,8.50365612678198,7.58972512852571,5.61078056559089,4.4084483109627,5.93609427404833,6.29671789594449,5.40621872954569,4.68188018884527,5.36131875800648,4.18806545213149,16.165904849427,13.6561633895496,20.5598116487016,12.6528539051975,15.8072034028469,14.8536573849172,23.7265869011223,19.191006350147,17.2654198597935,17.7644393288539,26.4724358958588,18.2537394205983,6119,"replication protein A3","protein_coding","hsa03030,hsa03420,hsa03430,hsa03440,hsa03460","DNA replication|Nucleotide excision repair|Mismatch repair|Homologous recombination|Fanconi anemia pathway","GO:0000723,GO:0000724,GO:0003684,GO:0003697,GO:0005515,GO:0005654,GO:0005662,GO:0006260,GO:0006281,GO:0006284,GO:0006289,GO:0006298,GO:0007346,GO:0035861,GO:0042127","telomere maintenance|double-strand break repair via homologous recombination|damaged DNA binding|single-stranded DNA binding|protein binding|nucleoplasm|DNA replication factor A complex|DNA replication|DNA repair|base-excision repair|nucleotide-excision repair|mismatch repair|regulation of mitotic cell cycle|site of double-strand break|regulation of cell population proliferation","WP531,WP466,WP5114,WP2446,WP4946,WP4753,WP45","DNA mismatch repair|DNA replication|Nucleotide excision repair in xeroderma pigmentosum |Retinoblastoma gene in cancer|DNA repair pathways, full network|Nucleotide excision repair|G1 to S cell cycle control","R-HSA-110312,R-HSA-110313,R-HSA-110314,R-HSA-110320,R-HSA-110373,R-HSA-1474165,R-HSA-1500620,R-HSA-157579,R-HSA-1640170,R-HSA-1640170,R-HSA-1643685,R-HSA-174414,R-HSA-174417,R-HSA-174437,R-HSA-176187,R-HSA-180786,R-HSA-212436,R-HSA-2262752,R-HSA-3371453,R-HSA-3371511,R-HSA-3371556,R-HSA-3700989,R-HSA-453279,R-HSA-5358508,R-HSA-5358508,R-HSA-5358565,R-HSA-5358606,R-HSA-5358606,R-HSA-5633007,R-HSA-5651801,R-HSA-5655862,R-HSA-5656121,R-HSA-5656169,R-HSA-5685938,R-HSA-5685942,R-HSA-5693532,R-HSA-5693538,R-HSA-5693567,R-HSA-5693579,R-HSA-5693607,R-HSA-5693616,R-HSA-5696395,R-HSA-5696397,R-HSA-5696398,R-HSA-5696399,R-HSA-5696400,R-HSA-6781827,R-HSA-6782135,R-HSA-6782210,R-HSA-6783310,R-HSA-6804756,R-HSA-68962,R-HSA-69002,R-HSA-69166,R-HSA-69183,R-HSA-69186,R-HSA-69190,R-HSA-69206,R-HSA-69239,R-HSA-69242,R-HSA-69278,R-HSA-69306,R-HSA-69473,R-HSA-69481,R-HSA-69620,R-HSA-73857,R-HSA-73884,R-HSA-73886,R-HSA-73893,R-HSA-73894,R-HSA-73894,R-HSA-73933,R-HSA-74160,R-HSA-8953897,R-HSA-912446,R-HSA-9675135,R-HSA-9675136,R-HSA-9701190,R-HSA-9709570","Translesion synthesis by REV1|Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template|Recognition of DNA damage by PCNA-containing replication complex|Translesion Synthesis by POLH|Resolution of AP sites via the multiple-nucleotide patch replacement pathway|Reproduction|Meiosis|Telomere Maintenance|Cell Cycle|Cell Cycle|Disease|Processive synthesis on the C-strand of the telomere|Telomere C-strand (Lagging Strand) Synthesis|Removal of the Flap Intermediate from the C-strand|Activation of ATR in response to replication stress|Extension of Telomeres|Generic Transcription Pathway|Cellular responses to stress|Regulation of HSF1-mediated heat shock response|HSF1 activation|Cellular response to heat stress|Transcriptional Regulation by TP53|Mitotic G1 phase and G1/S transition|Mismatch Repair|Mismatch Repair|Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)|Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)|Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)|Regulation of TP53 Activity|PCNA-Dependent Long Patch Base Excision Repair|Translesion synthesis by POLK|Translesion synthesis by POLI|Termination of translesion DNA synthesis|HDR through Single Strand Annealing (SSA)|HDR through Homologous Recombination (HRR)|DNA Double-Strand Break Repair|Homology Directed Repair|HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)|Homologous DNA Pairing and Strand Exchange|Processing of DNA double-strand break ends|Presynaptic phase of homologous DNA pairing and strand exchange|Formation of Incision Complex in GG-NER|Gap-filling DNA repair synthesis and ligation in GG-NER|Nucleotide Excision Repair|Global Genome Nucleotide Excision Repair (GG-NER)|Dual Incision in GG-NER|Transcription-Coupled Nucleotide Excision Repair (TC-NER)|Dual incision in TC-NER|Gap-filling DNA repair synthesis and ligation in TC-NER|Fanconi Anemia Pathway|Regulation of TP53 Activity through Phosphorylation|Activation of the pre-replicative complex|DNA Replication Pre-Initiation|Removal of the Flap Intermediate|Processive synthesis on the lagging strand|Lagging Strand Synthesis|DNA strand elongation|G1/S Transition|Synthesis of DNA|S Phase|Cell Cycle, Mitotic|DNA Replication|G2/M DNA damage checkpoint|G2/M Checkpoints|Cell Cycle Checkpoints|RNA Polymerase II Transcription|Base Excision Repair|Chromosome Maintenance|DNA Damage Bypass|DNA Repair|DNA Repair|Resolution of Abasic Sites (AP sites)|Gene expression (Transcription)|Cellular responses to stimuli|Meiotic recombination|Diseases of DNA repair|Diseases of DNA Double-Strand Break Repair|Defective homologous recombination repair (HRR) due to BRCA2 loss of function|Impaired BRCA2 binding to RAD51"]
["RPL23",235.682592849451,206.814721434664,266.495219517108,258.621330846841,219.134094310607,218.895151411257,283.322141786226,272.214872261121,236.022653159059,200.569726404517,281.500257596962,269.90905269698,255.924912068926,268.248704556047,270.062893750844,247.170235249847,351.782295645567,289.087024905697,343.743818417285,255.892654767061,336.076421713398,292.826106248915,369.279394143975,363.937706509882,331.761565058765,328.76020555541,443.725136080435,363.141127021207,9349,"ribosomal protein L23","protein_coding","hsa03010,hsa05171","Ribosome|Coronavirus disease - COVID-19","GO:0000122,GO:0001223,GO:0002181,GO:0003723,GO:0003735,GO:0005515,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0005840,GO:0005925,GO:0006412,GO:0006610,GO:0008284,GO:0010628,GO:0016020,GO:0022625,GO:0022626,GO:0031625,GO:0032986,GO:0032991,GO:0045202,GO:0050821,GO:0070062,GO:0070180,GO:0070314,GO:0072717,GO:1901798,GO:1903450,GO:1904667,GO:1990948,GO:2000059","negative regulation of transcription by RNA polymerase II|transcription coactivator binding|cytoplasmic translation|RNA binding|structural constituent of ribosome|protein binding|nucleoplasm|nucleolus|cytoplasm|cytosol|ribosome|focal adhesion|translation|ribosomal protein import into nucleus|positive regulation of cell population proliferation|positive regulation of gene expression|membrane|cytosolic large ribosomal subunit|cytosolic ribosome|ubiquitin protein ligase binding|protein-DNA complex disassembly|protein-containing complex|synapse|protein stabilization|extracellular exosome|large ribosomal subunit rRNA binding|G1 to G0 transition|cellular response to actinomycin D|positive regulation of signal transduction by p53 class mediator|regulation of G1 to G0 transition|negative regulation of ubiquitin protein ligase activity|ubiquitin ligase inhibitor activity|negative regulation of ubiquitin-dependent protein catabolic process","WP477,WP5287","Cytoplasmic ribosomal proteins|17q12 copy number variation syndrome","R-HSA-1266738,R-HSA-1430728,R-HSA-156827,R-HSA-156842,R-HSA-156902,R-HSA-1643685,R-HSA-168255,R-HSA-168273,R-HSA-1799339,R-HSA-1799339,R-HSA-192823,R-HSA-2262752,R-HSA-2408522,R-HSA-2408557,R-HSA-376176,R-HSA-392499,R-HSA-392499,R-HSA-422475,R-HSA-5663205,R-HSA-6791226,R-HSA-71291,R-HSA-72312,R-HSA-72613,R-HSA-72689,R-HSA-72706,R-HSA-72737,R-HSA-72764,R-HSA-72766,R-HSA-72766,R-HSA-8868773,R-HSA-8953854,R-HSA-8953897,R-HSA-9010553,R-HSA-927802,R-HSA-9633012,R-HSA-9675108,R-HSA-9711097,R-HSA-975956,R-HSA-975957,R-HSA-9824446","Developmental Biology|Metabolism|L13a-mediated translational silencing of Ceruloplasmin expression|Eukaryotic Translation Elongation|Peptide chain elongation|Disease|Influenza Infection|Influenza Viral RNA Transcription and Replication|SRP-dependent cotranslational protein targeting to membrane|SRP-dependent cotranslational protein targeting to membrane|Viral mRNA Translation|Cellular responses to stress|Selenoamino acid metabolism|Selenocysteine synthesis|Signaling by ROBO receptors|Metabolism of proteins|Metabolism of proteins|Axon guidance|Infectious disease|Major pathway of rRNA processing in the nucleolus and cytosol|Metabolism of amino acids and derivatives|rRNA processing|Eukaryotic Translation Initiation|Formation of a pool of free 40S subunits|GTP hydrolysis and joining of the 60S ribosomal subunit|Cap-dependent Translation Initiation|Eukaryotic Translation Termination|Translation|Translation|rRNA processing in the nucleus and cytosol|Metabolism of RNA|Cellular responses to stimuli|Regulation of expression of SLITs and ROBOs|Nonsense-Mediated Decay (NMD)|Response of EIF2AK4 (GCN2) to amino acid deficiency|Nervous system development|Cellular response to starvation|Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)|Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)|Viral Infection Pathways"]
["RPL39",786.983247867892,591.819941555828,838.844952510775,809.384597645768,698.968244390161,675.020261787876,870.186726227008,883.884893502341,808.075616967263,516.915857755425,895.401914796616,901.850699649326,890.458957270339,932.890072628447,877.740927314629,842.712479439902,1162.73254180679,961.915783732731,1184.79705571179,826.170093004739,1130.8940635335,1023.86384923434,1288.89424671493,1216.76689958727,1097.02771431688,1157.06228524206,1424.3097626675,1195.2308599225,6170,"ribosomal protein L39","protein_coding","hsa03010,hsa05171","Ribosome|Coronavirus disease - COVID-19","GO:0002181,GO:0002227,GO:0003723,GO:0003735,GO:0005615,GO:0005829,GO:0006412,GO:0019731,GO:0022625,GO:0022626,GO:0042788,GO:0050830,GO:0061844","cytoplasmic translation|innate immune response in mucosa|RNA binding|structural constituent of ribosome|extracellular space|cytosol|translation|antibacterial humoral response|cytosolic large ribosomal subunit|cytosolic ribosome|polysomal ribosome|defense response to Gram-positive bacterium|antimicrobial humoral immune response mediated by antimicrobial peptide","WP477","Cytoplasmic ribosomal proteins","R-HSA-1266738,R-HSA-1430728,R-HSA-156827,R-HSA-156842,R-HSA-156902,R-HSA-1643685,R-HSA-168255,R-HSA-168273,R-HSA-1799339,R-HSA-1799339,R-HSA-192823,R-HSA-2262752,R-HSA-2408522,R-HSA-2408557,R-HSA-376176,R-HSA-392499,R-HSA-392499,R-HSA-422475,R-HSA-5663205,R-HSA-6791226,R-HSA-71291,R-HSA-72312,R-HSA-72613,R-HSA-72689,R-HSA-72706,R-HSA-72737,R-HSA-72764,R-HSA-72766,R-HSA-72766,R-HSA-8868773,R-HSA-8953854,R-HSA-8953897,R-HSA-9010553,R-HSA-927802,R-HSA-9633012,R-HSA-9675108,R-HSA-9711097,R-HSA-975956,R-HSA-975957,R-HSA-9824446","Developmental Biology|Metabolism|L13a-mediated translational silencing of Ceruloplasmin expression|Eukaryotic Translation Elongation|Peptide chain elongation|Disease|Influenza Infection|Influenza Viral RNA Transcription and Replication|SRP-dependent cotranslational protein targeting to membrane|SRP-dependent cotranslational protein targeting to membrane|Viral mRNA Translation|Cellular responses to stress|Selenoamino acid metabolism|Selenocysteine synthesis|Signaling by ROBO receptors|Metabolism of proteins|Metabolism of proteins|Axon guidance|Infectious disease|Major pathway of rRNA processing in the nucleolus and cytosol|Metabolism of amino acids and derivatives|rRNA processing|Eukaryotic Translation Initiation|Formation of a pool of free 40S subunits|GTP hydrolysis and joining of the 60S ribosomal subunit|Cap-dependent Translation Initiation|Eukaryotic Translation Termination|Translation|Translation|rRNA processing in the nucleus and cytosol|Metabolism of RNA|Cellular responses to stimuli|Regulation of expression of SLITs and ROBOs|Nonsense-Mediated Decay (NMD)|Response of EIF2AK4 (GCN2) to amino acid deficiency|Nervous system development|Cellular response to starvation|Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)|Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)|Viral Infection Pathways"]
["RPS13",696.92302197379,584.315740135619,808.398057890233,710.234616513204,611.07911585963,632.927560928286,859.916783839403,758.085563361009,759.40615708309,521.068586286898,827.48350702008,826.522594304423,794.737415429267,784.052701644015,858.724712574042,754.099554708514,1041.24427098788,874.61374539176,1122.71522890139,803.424153882519,928.585038223916,936.572034890359,1138.24431354619,1103.64168848338,973.967154108678,1034.34772336549,1313.65619135068,1040.41494073334,6207,"ribosomal protein S13","protein_coding","hsa03010,hsa05171","Ribosome|Coronavirus disease - COVID-19","GO:0002181,GO:0003723,GO:0003729,GO:0003735,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0005840,GO:0005925,GO:0006412,GO:0014069,GO:0016020,GO:0022626,GO:0022627,GO:0032040,GO:0033119,GO:0042274,GO:0048027,GO:0070062,GO:0070181","cytoplasmic translation|RNA binding|mRNA binding|structural constituent of ribosome|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|ribosome|focal adhesion|translation|postsynaptic density|membrane|cytosolic ribosome|cytosolic small ribosomal subunit|small-subunit processome|negative regulation of RNA splicing|ribosomal small subunit biogenesis|mRNA 5'-UTR binding|extracellular exosome|small ribosomal subunit rRNA binding","WP477","Cytoplasmic ribosomal proteins","R-HSA-1266738,R-HSA-1430728,R-HSA-156827,R-HSA-156842,R-HSA-156902,R-HSA-1643685,R-HSA-168255,R-HSA-168273,R-HSA-1799339,R-HSA-1799339,R-HSA-192823,R-HSA-2262752,R-HSA-2408522,R-HSA-2408557,R-HSA-376176,R-HSA-392499,R-HSA-392499,R-HSA-422475,R-HSA-5663205,R-HSA-6791226,R-HSA-71291,R-HSA-72312,R-HSA-72613,R-HSA-72649,R-HSA-72662,R-HSA-72689,R-HSA-72695,R-HSA-72702,R-HSA-72706,R-HSA-72737,R-HSA-72764,R-HSA-72766,R-HSA-72766,R-HSA-8868773,R-HSA-8953854,R-HSA-8953897,R-HSA-9010553,R-HSA-927802,R-HSA-9633012,R-HSA-9675108,R-HSA-9678108,R-HSA-9679506,R-HSA-9692914,R-HSA-9694516,R-HSA-9705683,R-HSA-9711097,R-HSA-9735869,R-HSA-9754678,R-HSA-975956,R-HSA-975957,R-HSA-9824446","Developmental Biology|Metabolism|L13a-mediated translational silencing of Ceruloplasmin expression|Eukaryotic Translation Elongation|Peptide chain elongation|Disease|Influenza Infection|Influenza Viral RNA Transcription and Replication|SRP-dependent cotranslational protein targeting to membrane|SRP-dependent cotranslational protein targeting to membrane|Viral mRNA Translation|Cellular responses to stress|Selenoamino acid metabolism|Selenocysteine synthesis|Signaling by ROBO receptors|Metabolism of proteins|Metabolism of proteins|Axon guidance|Infectious disease|Major pathway of rRNA processing in the nucleolus and cytosol|Metabolism of amino acids and derivatives|rRNA processing|Eukaryotic Translation Initiation|Translation initiation complex formation|Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S|Formation of a pool of free 40S subunits|Formation of the ternary complex, and subsequently, the 43S complex|Ribosomal scanning and start codon recognition|GTP hydrolysis and joining of the 60S ribosomal subunit|Cap-dependent Translation Initiation|Eukaryotic Translation Termination|Translation|Translation|rRNA processing in the nucleus and cytosol|Metabolism of RNA|Cellular responses to stimuli|Regulation of expression of SLITs and ROBOs|Nonsense-Mediated Decay (NMD)|Response of EIF2AK4 (GCN2) to amino acid deficiency|Nervous system development|SARS-CoV-1 Infection|SARS-CoV Infections|SARS-CoV-1-host interactions|SARS-CoV-2 Infection|SARS-CoV-2-host interactions|Cellular response to starvation|SARS-CoV-1 modulates host translation machinery|SARS-CoV-2 modulates host translation machinery|Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)|Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)|Viral Infection Pathways"]
["RPS14",294.613294399233,234.751497357033,339.03213885301,300.340671417181,273.72695637468,277.492459712544,377.493374565734,369.460469538133,330.420371351847,273.752190529916,361.336866467025,356.407299665267,329.991168480574,346.763138743477,358.818490822299,331.623474256252,439.740541632749,353.732148279585,450.878634400057,336.685502218451,401.914509719184,367.470862581965,453.255118971411,450.723510092626,437.371936113495,412.207531993414,574.610366212445,446.760652587133,6208,"ribosomal protein S14","protein_coding","hsa03010,hsa05171","Ribosome|Coronavirus disease - COVID-19","GO:0000028,GO:0000122,GO:0002181,GO:0003723,GO:0003735,GO:0005515,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0005925,GO:0006412,GO:0006417,GO:0014069,GO:0016020,GO:0022626,GO:0022627,GO:0030218,GO:0030490,GO:0032040,GO:0042274,GO:0045182,GO:0048027,GO:0070062","ribosomal small subunit assembly|negative regulation of transcription by RNA polymerase II|cytoplasmic translation|RNA binding|structural constituent of ribosome|protein binding|nucleoplasm|nucleolus|cytoplasm|cytosol|focal adhesion|translation|regulation of translation|postsynaptic density|membrane|cytosolic ribosome|cytosolic small ribosomal subunit|erythrocyte differentiation|maturation of SSU-rRNA|small-subunit processome|ribosomal small subunit biogenesis|translation regulator activity|mRNA 5'-UTR binding|extracellular exosome","WP477","Cytoplasmic ribosomal proteins","R-HSA-1266738,R-HSA-1430728,R-HSA-156827,R-HSA-156842,R-HSA-156902,R-HSA-1643685,R-HSA-168255,R-HSA-168273,R-HSA-1799339,R-HSA-1799339,R-HSA-192823,R-HSA-2262752,R-HSA-2408522,R-HSA-2408557,R-HSA-376176,R-HSA-392499,R-HSA-392499,R-HSA-422475,R-HSA-5663205,R-HSA-6790901,R-HSA-6791226,R-HSA-71291,R-HSA-72312,R-HSA-72312,R-HSA-72613,R-HSA-72649,R-HSA-72662,R-HSA-72689,R-HSA-72695,R-HSA-72702,R-HSA-72706,R-HSA-72737,R-HSA-72764,R-HSA-72766,R-HSA-72766,R-HSA-8868773,R-HSA-8868773,R-HSA-8953854,R-HSA-8953854,R-HSA-8953897,R-HSA-9010553,R-HSA-927802,R-HSA-9633012,R-HSA-9675108,R-HSA-9678108,R-HSA-9679506,R-HSA-9692914,R-HSA-9694516,R-HSA-9705683,R-HSA-9711097,R-HSA-9735869,R-HSA-9754678,R-HSA-975956,R-HSA-975957,R-HSA-9824446","Developmental Biology|Metabolism|L13a-mediated translational silencing of Ceruloplasmin expression|Eukaryotic Translation Elongation|Peptide chain elongation|Disease|Influenza Infection|Influenza Viral RNA Transcription and Replication|SRP-dependent cotranslational protein targeting to membrane|SRP-dependent cotranslational protein targeting to membrane|Viral mRNA Translation|Cellular responses to stress|Selenoamino acid metabolism|Selenocysteine synthesis|Signaling by ROBO receptors|Metabolism of proteins|Metabolism of proteins|Axon guidance|Infectious disease|rRNA modification in the nucleus and cytosol|Major pathway of rRNA processing in the nucleolus and cytosol|Metabolism of amino acids and derivatives|rRNA processing|rRNA processing|Eukaryotic Translation Initiation|Translation initiation complex formation|Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S|Formation of a pool of free 40S subunits|Formation of the ternary complex, and subsequently, the 43S complex|Ribosomal scanning and start codon recognition|GTP hydrolysis and joining of the 60S ribosomal subunit|Cap-dependent Translation Initiation|Eukaryotic Translation Termination|Translation|Translation|rRNA processing in the nucleus and cytosol|rRNA processing in the nucleus and cytosol|Metabolism of RNA|Metabolism of RNA|Cellular responses to stimuli|Regulation of expression of SLITs and ROBOs|Nonsense-Mediated Decay (NMD)|Response of EIF2AK4 (GCN2) to amino acid deficiency|Nervous system development|SARS-CoV-1 Infection|SARS-CoV Infections|SARS-CoV-1-host interactions|SARS-CoV-2 Infection|SARS-CoV-2-host interactions|Cellular response to starvation|SARS-CoV-1 modulates host translation machinery|SARS-CoV-2 modulates host translation machinery|Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)|Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)|Viral Infection Pathways"]
["RPS6KB2",24.5146833655949,23.9926189298309,23.4950244563187,29.0518189553908,20.8615482600625,24.3935047210074,22.5673716542448,23.8302291845733,18.3617629158217,27.4114755874736,26.5522199314715,22.3502373984841,15.4566689406164,18.7434121567593,16.9899786777882,17.6985474315419,29.9428063158047,30.0376634210439,35.93370257819,27.4641371810187,33.3072552222472,33.0844087448562,30.8718359629965,28.193807001502,27.7805081450529,35.2570001715321,31.0987455872315,37.4724735181444,6199,"ribosomal protein S6 kinase B2","protein_coding","hsa04012,hsa04350,hsa04371,hsa04066,hsa04151,hsa04152,hsa04150,hsa04140,hsa04666,hsa04910,hsa04211,hsa04213,hsa04714,hsa05200,hsa05205,hsa05207,hsa05231,hsa05235,hsa05210,hsa05212,hsa05225,hsa05226,hsa05221,hsa05224,hsa05170,hsa05163,hsa05165,hsa05131,hsa04931,hsa01521,hsa01522","ErbB signaling pathway|TGF-beta signaling pathway|Apelin signaling pathway|HIF-1 signaling pathway|PI3K-Akt signaling pathway|AMPK signaling pathway|mTOR signaling pathway|Autophagy - animal|Fc gamma R-mediated phagocytosis|Insulin signaling pathway|Longevity regulating pathway|Longevity regulating pathway - multiple species|Thermogenesis|Pathways in cancer|Proteoglycans in cancer|Chemical carcinogenesis - receptor activation|Choline metabolism in cancer|PD-L1 expression and PD-1 checkpoint pathway in cancer|Colorectal cancer|Pancreatic cancer|Hepatocellular carcinoma|Gastric cancer|Acute myeloid leukemia|Breast cancer|Human immunodeficiency virus 1 infection|Human cytomegalovirus infection|Human papillomavirus infection|Shigellosis|Insulin resistance|EGFR tyrosine kinase inhibitor resistance|Endocrine resistance","GO:0004672,GO:0004674,GO:0004711,GO:0005524,GO:0005654,GO:0005737,GO:0006412,GO:0007165,GO:0016310,GO:0018105,GO:0031929,GO:0042277,GO:0043491,GO:0045948,GO:0106310","protein kinase activity|protein serine/threonine kinase activity|ribosomal protein S6 kinase activity|ATP binding|nucleoplasm|cytoplasm|translation|signal transduction|phosphorylation|peptidyl-serine phosphorylation|TOR signaling|peptide binding|phosphatidylinositol 3-kinase/protein kinase B signal transduction|positive regulation of translational initiation|protein serine kinase activity","WP477,WP4321,WP4262,WP4806,WP673,WP127,WP2035,WP3932,WP481,WP49,WP1403,WP4263,WP4674,WP4566,WP5087,WP4172,WP3915","Cytoplasmic ribosomal proteins|Thermogenesis|Breast cancer pathway|EGFR tyrosine kinase inhibitor resistance|ErbB signaling pathway|IL-5 signaling pathway|Follicle stimulating hormone (FSH) signaling pathway|Focal adhesion: PI3K-Akt-mTOR-signaling pathway|Insulin signaling|IL-2 signaling pathway|AMP-activated protein kinase signaling|Pancreatic adenocarcinoma pathway|Head and neck squamous cell carcinoma|Translation inhibitors in chronically activated PDGFRA cells|Pleural mesothelioma|PI3K-Akt signaling pathway|Angiopoietin-like protein 8 regulatory pathway","R-HSA-1257604,R-HSA-162582,R-HSA-1643685,R-HSA-198693,R-HSA-2219528,R-HSA-5663202,R-HSA-5674400,R-HSA-9006925","PIP3 activates AKT signaling|Signal Transduction|Disease|AKT phosphorylates targets in the nucleus|PI3K/AKT Signaling in Cancer|Diseases of signal transduction by growth factor receptors and second messengers|Constitutive Signaling by AKT1 E17K in Cancer|Intracellular signaling by second messengers"]
["RRM1",52.7531852467421,39.9597621637154,24.2473873817534,35.9380451509696,39.124548127793,31.5479135893531,22.0175798306223,29.1791016450738,36.2382106315859,29.6307960451681,24.8056604591274,35.4205917339449,31.7557664763132,18.2429501633699,19.3636447525163,18.6140168211558,55.2278294637205,47.6544756813318,42.5428951788403,48.9116761586499,53.137595384401,47.1815819682662,50.5481461065638,57.9365945216309,53.8157226293563,48.8232518669474,49.9046553029209,45.1852618343763,6240,"ribonucleotide reductase catalytic subunit M1","protein_coding","hsa00230,hsa00240,hsa00480,hsa00983","Purine metabolism|Pyrimidine metabolism|Glutathione metabolism|Drug metabolism - other enzymes","GO:0000731,GO:0004748,GO:0005515,GO:0005524,GO:0005635,GO:0005739,GO:0005829,GO:0005971,GO:0006206,GO:0006264,GO:0006281,GO:0008584,GO:0009185,GO:0009263,GO:0009265,GO:0010212,GO:0010971,GO:0021846,GO:0042802,GO:0042995,GO:0043025,GO:0051290,GO:0060041,GO:0061731,GO:0070318,GO:0097718,GO:1900087","DNA synthesis involved in DNA repair|ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor|protein binding|ATP binding|nuclear envelope|mitochondrion|cytosol|ribonucleoside-diphosphate reductase complex|pyrimidine nucleobase metabolic process|mitochondrial DNA replication|DNA repair|male gonad development|ribonucleoside diphosphate metabolic process|deoxyribonucleotide biosynthetic process|2'-deoxyribonucleotide biosynthetic process|response to ionizing radiation|positive regulation of G2/M transition of mitotic cell cycle|cell proliferation in forebrain|identical protein binding|cell projection|neuronal cell body|protein heterotetramerization|retina development in camera-type eye|ribonucleoside-diphosphate reductase activity|positive regulation of G0 to G1 transition|disordered domain specific binding|positive regulation of G1/S transition of mitotic cell cycle","WP2446,WP4225,WP1601,WP4022,WP4584","Retinoblastoma gene in cancer|Pyrimidine metabolism and related diseases|Fluoropyrimidine activity|Pyrimidine metabolism|Biomarkers for pyrimidine metabolism disorders","R-HSA-1430728,R-HSA-15869,R-HSA-499943","Metabolism|Metabolism of nucleotides|Interconversion of nucleotide di- and triphosphates"]
["RSPO2",0.00764065057688297,0.0581402110205726,0.0358665812006092,0.0146556571916002,0.0149322442292431,7.17496026560243E-3,0.0142573159763511,0.00749239813493135,0.222878303396691,0.117742813353492,0.129340622530716,0.184491103517512,0.159856200923138,0.211248322012838,0.305547778696646,0.239068413451204,0.0514221589125765,0.148462122443007,0.0706165221553943,0.0514318814363368,0.0576931292946145,0.00726271998406617,0.0452580251525674,0.0671823578001902,0.0227253551989879,0.0943799004872826,0.125693192946157,0.057464764756152,340419,"R-spondin 2","protein_coding","hsa04310","Wnt signaling pathway","GO:0001649,GO:0005102,GO:0005515,GO:0005576,GO:0008201,GO:0009986,GO:0030177,GO:0030282,GO:0035115,GO:0035116,GO:0042489,GO:0060070,GO:0060173,GO:0060437,GO:0060441,GO:0060535,GO:0071542,GO:0090263","osteoblast differentiation|signaling receptor binding|protein binding|extracellular region|heparin binding|cell surface|positive regulation of Wnt signaling pathway|bone mineralization|embryonic forelimb morphogenesis|embryonic hindlimb morphogenesis|negative regulation of odontogenesis of dentin-containing tooth|canonical Wnt signaling pathway|limb development|lung growth|epithelial tube branching involved in lung morphogenesis|trachea cartilage morphogenesis|dopaminergic neuron differentiation|positive regulation of canonical Wnt signaling pathway",null,null,"R-HSA-162582,R-HSA-195721,R-HSA-201681,R-HSA-4641263","Signal Transduction|Signaling by WNT|TCF dependent signaling in response to WNT|Regulation of FZD by ubiquitination"]
["RTCA",18.1704858252379,16.3735074278357,12.5007997792416,15.8743907896385,16.4820539987203,15.1287435865616,13.9917797195003,14.5614363415646,15.6871808443255,11.3464824468315,12.8186894092703,14.0728950646884,15.0812470206797,12.9950050660684,13.8002380823915,12.1266277081005,14.5396605396879,14.721886069249,16.5507287968752,15.4519418108944,14.0356249812003,15.2638419830737,15.8217821264355,14.7437642861679,15.1285480392757,14.3094703859984,14.9594875613888,13.6540313675687,8634,"RNA 3'-terminal phosphate cyclase","protein_coding",null,null,"GO:0003723,GO:0003963,GO:0005524,GO:0005634,GO:0005654,GO:0006396","RNA binding|RNA-3'-phosphate cyclase activity|ATP binding|nucleus|nucleoplasm|RNA processing"]
["RTN4RL2",0.0727236022533537,0.126815721070502,0.227585069200988,0.360355196881954,0.130281145244709,0.0796730299996931,0.0904672855477822,0.10696880646598,0.0609584047370013,0.128410608718028,0.193778306777134,0.146331972394286,0.0806860844097005,0.231110171192413,0.0450883621901358,0.091937362399809,0.29133057657305,0.224295292899507,0.0448084694539984,0.18648682189866,0.183040791503057,0.334111244159073,0.16751981252515,0.0118414947201774,0.168233025178119,0.195784757596335,0.175933235577408,0.205105801544215,349667,"reticulon 4 receptor like 2","protein_coding",null,null,"GO:0005576,GO:0005615,GO:0005886,GO:0007166,GO:0009986,GO:0010977,GO:0030424,GO:0030425,GO:0031012,GO:0031103,GO:0038023,GO:0043005,GO:0043204,GO:0045121,GO:0070062,GO:0098552","extracellular region|extracellular space|plasma membrane|cell surface receptor signaling pathway|cell surface|negative regulation of neuron projection development|axon|dendrite|extracellular matrix|axon regeneration|signaling receptor activity|neuron projection|perikaryon|membrane raft|extracellular exosome|side of membrane",null,null,"R-HSA-163125,R-HSA-392499,R-HSA-597592","Post-translational modification: synthesis of GPI-anchored proteins|Metabolism of proteins|Post-translational protein modification"]
["RUSC1",10.4171359701563,9.95764681906829,8.20099672977788,10.372795298081,8.70767988648545,8.25633104802459,6.78839834277031,8.79414513621147,8.37529394683668,10.5264651962887,9.67017932920569,9.47566708294784,6.93413062785805,7.4942342339393,6.13613744607166,6.51108554683508,8.56263349706782,9.73437265265395,8.3698676864543,9.74861741021829,9.01654230273288,9.23289277151186,7.19318488306992,7.40164118894905,8.23965798592817,9.33268461934986,6.30467619566793,9.86142358780525,23623,"RUN and SH3 domain containing 1","protein_coding",null,null,"GO:0000209,GO:0003779,GO:0005515,GO:0005634,GO:0005769,GO:0005794,GO:0005829,GO:0005874,GO:0014069,GO:0015630,GO:0031410","protein polyubiquitination|actin binding|protein binding|nucleus|early endosome|Golgi apparatus|cytosol|microtubule|postsynaptic density|microtubule cytoskeleton|cytoplasmic vesicle","WP4754","IL-18 signaling pathway"]
["S100PBP",6.95484242911498,7.20029172794823,6.08701689760046,5.97549495458122,6.63601683936453,6.2002114126771,5.96118478696744,5.56974453624278,6.71121298938893,5.34630160019029,5.50495016174163,6.41322175173731,6.59512331654107,5.53810400512593,5.81286400734662,6.26500506941473,5.91879079906069,5.63642431146156,5.65299164837131,5.78634221197412,5.74028587471514,6.04028419009002,5.86691923262278,5.85933022957831,5.92632431825209,5.37340971897471,5.42438146232729,4.94807156683259,64766,"S100P binding protein","protein_coding",null,null,"GO:0005515,GO:0005634,GO:0005829,GO:0016607,GO:0048306","protein binding|nucleus|cytosol|nuclear speck|calcium-dependent protein binding"]
["S100Z",0,0.00974342886569353,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.0295460020048701,0.00473905311997438,0.00946741744876425,0.029551588345712,0.00966850466233138,0.00486849251449467,0.0353946478297487,0.0650505976343852,0.0406232456226636,9.73332813748032E-3,0,0.0096302341848615,170591,"S100 calcium binding protein Z","protein_coding",null,null,"GO:0005509,GO:0005515,GO:0008150,GO:0042803,GO:0048306","calcium ion binding|protein binding|biological_process|protein homodimerization activity|calcium-dependent protein binding"]
["SAMD5",0.720492178831715,0.73912756932199,0.885371525858867,0.687376163495204,0.925197338919199,0.860778356499024,0.689809887339428,0.565949711008366,1.27868997619719,0.831984955062681,1.12102446082597,1.22963088137868,1.45287213525059,1.20117781223386,1.79616488124689,1.53079696722346,0.667322324225678,0.701548971544285,0.889021102601161,1.04832943219858,0.875860176973909,0.864135620068891,1.21030067263583,0.98767279331889,0.830248241325243,0.530473193825827,0.810366307819412,0.617058670416816,389432,"sterile alpha motif domain containing 5","protein_coding",null,null,"GO:0005737","cytoplasm"]
["SART3",13.0445461138379,14.3798224574672,14.158019409874,13.8724096774667,13.2132192124634,14.1435626530204,12.604264935177,13.4014377269422,13.3675387349984,13.9615393530617,14.0522405767124,14.3755983919876,12.9789007642831,11.8193512576234,14.1883091210007,12.320549508881,11.8045139514331,12.389423667034,11.0455697317568,13.5046453438571,12.0037212396979,12.5785028145855,10.9176282214193,12.3083090761392,12.4405268939108,11.8573241132041,10.9812522417875,12.9249909630137,9733,"spliceosome associated factor 3%2C U4/U6 recycling protein","protein_coding",null,null,"GO:0000244,GO:0000387,GO:0000398,GO:0000902,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006334,GO:0010468,GO:0015030,GO:0016607,GO:0017070,GO:0030621,GO:0030624,GO:0042393,GO:0048872,GO:0061574,GO:0071425,GO:0140673,GO:1990381","spliceosomal tri-snRNP complex assembly|spliceosomal snRNP assembly|mRNA splicing, via spliceosome|cell morphogenesis|RNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|nucleosome assembly|regulation of gene expression|Cajal body|nuclear speck|U6 snRNA binding|U4 snRNA binding|U6atac snRNA binding|histone binding|homeostasis of number of cells|ASAP complex|hematopoietic stem cell proliferation|transcription elongation-coupled chromatin remodeling|ubiquitin-specific protease binding"]
["SCAF4",6.11900078405868,7.35890146566551,6.071050901081,6.238858675191,6.11759926758062,5.93946911339141,5.51280160958362,5.79409260009425,6.05992916133931,6.06282711482026,5.84738206959782,5.78495026597893,5.56611046881942,5.39598470507331,5.92209296347179,5.27283164984119,4.81452855194083,5.23687020636594,4.39416873451079,5.45914789664086,4.99781197124378,4.8292717775998,4.57508059421942,4.54016705683883,5.16037034178509,4.8111490819261,4.18971660370873,5.03854021180696,57466,"SR-related CTD associated factor 4","protein_coding",null,null,"GO:0003723,GO:0005634,GO:0005654,GO:1990269,GO:2000805","RNA binding|nucleus|nucleoplasm|RNA polymerase II C-terminal domain phosphoserine binding|negative regulation of termination of RNA polymerase II transcription, poly(A)-coupled"]
["SCAND1",22.1003612205803,23.9818299984512,32.9055422826082,29.4946285618371,19.207866483918,26.7309192871685,32.5990401750729,29.4092026875363,26.4098276249305,30.2643557768098,39.8850037492237,28.9522144395903,25.6647234324414,31.2785466426934,33.2904143006614,31.1218588046956,27.8320950640911,31.8106669653979,39.4272102852285,29.2292252196094,30.848502909782,31.6587499203815,29.2698177219381,28.9051706546416,25.2437234296305,37.5325843523165,35.1364810874156,36.7107279416713,51282,"SCAN domain containing 1","protein_coding",null,null,"GO:0005515,GO:0005634,GO:0045893","protein binding|nucleus|positive regulation of DNA-templated transcription"]
["SCHLAP1",0,0,0,0,0.0157256589972446,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.0158875933072893,0,0,0,0,0,101669767,"SWI/SNF complex antagonist associated with prostate cancer 1","non_coding"]
["SCPEP1",40.2450826523052,37.6797546686245,37.2702682561957,40.7483972001111,41.8461585004034,41.9781516154746,40.3863275197562,43.9590804071144,42.7511975198747,34.6973927120248,40.629770428172,44.6926100550746,42.9118339432266,50.8242393615059,46.6053757282022,43.1558664420104,33.8548733473477,36.5369683925573,31.0285252700641,33.0390061704798,30.1792669335246,33.3377202348784,26.1550434282638,32.1558590936141,36.397723033277,32.512714798656,27.4279456820469,30.784618563408,59342,"serine carboxypeptidase 1","protein_coding",null,null,"GO:0004185,GO:0005829,GO:0006508,GO:0042573,GO:0045776,GO:0070062,GO:0097746","serine-type carboxypeptidase activity|cytosol|proteolysis|retinoic acid metabolic process|negative regulation of blood pressure|extracellular exosome|blood vessel diameter maintenance"]
["SDC4",99.7885457215869,95.2883348053442,100.842430289284,104.043522300572,95.8962782312748,97.3877539000218,98.8863864896978,108.565210261862,111.040990228672,89.2335742761046,95.6304864875287,116.140432801018,99.5090084778703,112.003577652031,93.3976174864372,98.1066303382638,98.4400778080714,107.650890639592,82.9878233750275,93.181105937651,85.6170675378522,97.539513434502,71.6367508483803,87.3414874003092,95.5166247344577,98.4046868750677,74.5115563428475,87.3148401075162,6385,"syndecan 4","protein_coding","hsa04512,hsa04514,hsa05205,hsa05418","ECM-receptor interaction|Cell adhesion molecules|Proteoglycans in cancer|Fluid shear stress and atherosclerosis","GO:0001657,GO:0001843,GO:0001968,GO:0005080,GO:0005515,GO:0005796,GO:0005886,GO:0005925,GO:0009986,GO:0010762,GO:0016477,GO:0042060,GO:0042130,GO:0042802,GO:0043034,GO:0043202,GO:0051496,GO:0051894,GO:0060122,GO:0070053,GO:0070062,GO:1903543,GO:1903553","ureteric bud development|neural tube closure|fibronectin binding|protein kinase C binding|protein binding|Golgi lumen|plasma membrane|focal adhesion|cell surface|regulation of fibroblast migration|cell migration|wound healing|negative regulation of T cell proliferation|identical protein binding|costamere|lysosomal lumen|positive regulation of stress fiber assembly|positive regulation of focal adhesion assembly|inner ear receptor cell stereocilium organization|thrombospondin receptor activity|extracellular exosome|positive regulation of exosomal secretion|positive regulation of extracellular exosome assembly","WP4754","IL-18 signaling pathway","R-HSA-109582,R-HSA-1430728,R-HSA-1430728,R-HSA-1474244,R-HSA-1474244,R-HSA-1630316,R-HSA-1630316,R-HSA-1638091,R-HSA-1638091,R-HSA-1643685,R-HSA-1643685,R-HSA-1793185,R-HSA-196854,R-HSA-1971475,R-HSA-2022928,R-HSA-2022928,R-HSA-2024096,R-HSA-202733,R-HSA-2187338,R-HSA-3000170,R-HSA-3000170,R-HSA-3000171,R-HSA-3000171,R-HSA-3560782,R-HSA-3560783,R-HSA-3560801,R-HSA-3656237,R-HSA-3656253,R-HSA-3781865,R-HSA-4420332,R-HSA-5663205,R-HSA-5663205,R-HSA-5668914,R-HSA-6806667,R-HSA-71387,R-HSA-71387,R-HSA-9679506,R-HSA-9679506,R-HSA-9694516,R-HSA-9694516,R-HSA-9694614,R-HSA-9694614,R-HSA-9709957,R-HSA-975634,R-HSA-9772572,R-HSA-9772572,R-HSA-9824446,R-HSA-9824446","Hemostasis|Metabolism|Metabolism|Extracellular matrix organization|Extracellular matrix organization|Glycosaminoglycan metabolism|Glycosaminoglycan metabolism|Heparan sulfate/heparin (HS-GAG) metabolism|Heparan sulfate/heparin (HS-GAG) metabolism|Disease|Disease|Chondroitin sulfate/dermatan sulfate metabolism|Metabolism of vitamins and cofactors|A tetrasaccharide linker sequence is required for GAG synthesis|HS-GAG biosynthesis|HS-GAG biosynthesis|HS-GAG degradation|Cell surface interactions at the vascular wall|Visual phototransduction|Syndecan interactions|Syndecan interactions|Non-integrin membrane-ECM interactions|Non-integrin membrane-ECM interactions|Diseases associated with glycosaminoglycan metabolism|Defective B4GALT7 causes EDS, progeroid type|Defective B3GAT3 causes JDSSDHD|Defective EXT2 causes exostoses 2|Defective EXT1 causes exostoses 1, TRPS2 and CHDS|Diseases of glycosylation|Defective B3GALT6 causes EDSP2 and SEMDJL1|Infectious disease|Infectious disease|Diseases of metabolism|Metabolism of fat-soluble vitamins|Metabolism of carbohydrates|Metabolism of carbohydrates|SARS-CoV Infections|SARS-CoV Infections|SARS-CoV-2 Infection|SARS-CoV-2 Infection|Attachment and Entry|Attachment and Entry|Sensory Perception|Retinoid metabolism and transport|Early SARS-CoV-2 Infection Events|Early SARS-CoV-2 Infection Events|Viral Infection Pathways|Viral Infection Pathways"]
["SDHB",57.8961075988472,56.3571108936175,63.0567148463389,65.5865927698578,51.4872019503877,55.6143540807992,65.6870927767817,58.8040609261531,49.4201498423484,47.1669590100066,54.7476555065188,53.1448889849861,52.4572883937143,48.7403381728551,52.4846304705866,47.5414894370575,65.4174973906863,65.2659967793589,79.4532302326716,62.1098494277815,65.6496086498173,64.1960334304693,73.8049146729386,68.524151649772,64.8246242481697,67.5029081363153,85.4252752007814,70.5580123286606,6390,"succinate dehydrogenase complex iron sulfur subunit B","protein_coding","hsa00020,hsa00190,hsa04714,hsa05208,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022,hsa05415,hsa04932","Citrate cycle (TCA cycle)|Oxidative phosphorylation|Thermogenesis|Chemical carcinogenesis - reactive oxygen species|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases|Diabetic cardiomyopathy|Non-alcoholic fatty liver disease","GO:0005515,GO:0005654,GO:0005739,GO:0005743,GO:0005749,GO:0005886,GO:0006099,GO:0006121,GO:0008177,GO:0009055,GO:0009060,GO:0022904,GO:0031966,GO:0042776,GO:0046872,GO:0048039,GO:0051537,GO:0051538,GO:0051539,GO:0102040","protein binding|nucleoplasm|mitochondrion|mitochondrial inner membrane|mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)|plasma membrane|tricarboxylic acid cycle|mitochondrial electron transport, succinate to ubiquinone|succinate dehydrogenase (ubiquinone) activity|electron transfer activity|aerobic respiration|respiratory electron transport chain|mitochondrial membrane|proton motive force-driven mitochondrial ATP synthesis|metal ion binding|ubiquinone binding|2 iron, 2 sulfur cluster binding|3 iron, 4 sulfur cluster binding|4 iron, 4 sulfur cluster binding|fumarate reductase (menaquinone)","WP78,WP4920,WP111,WP4290,WP4396","TCA cycle (aka Krebs or citric acid cycle)|Mitochondrial complex II assembly|Electron transport chain: OXPHOS system in mitochondria|Metabolic reprogramming in colon cancer|Nonalcoholic fatty liver disease","R-HSA-1428517,R-HSA-1428517,R-HSA-1430728,R-HSA-1430728,R-HSA-163200,R-HSA-611105,R-HSA-71403,R-HSA-71406","The citric acid (TCA) cycle and respiratory electron transport|The citric acid (TCA) cycle and respiratory electron transport|Metabolism|Metabolism|Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.|Respiratory electron transport|Citric acid cycle (TCA cycle)|Pyruvate metabolism and Citric Acid (TCA) cycle"]
["SEC24B-AS1",0.225339312311332,0.428670145204974,0.608225259131083,0.432227030904623,0.357812146985374,0.740617842087012,0.656998573204897,0.662901081380259,0.878310607353776,0.488318940647869,0.662245611703771,0.680130212340422,0.294656570980581,0.698208701098751,0.654888437244396,0.267069871966007,0.324975148488258,0.886118749628481,0.963218216935899,0.43338212320023,0.61147482804104,0.535483304154346,0.834223159552027,0.853082562160828,0.698145708307467,0.77615918162968,0.872226855421318,0.900341361289178,100533182,"SEC24B antisense RNA 1","non_coding"]
["SELENOO",9.36324077159342,9.98414874743954,11.0962624418944,12.0260355679867,9.86469968963164,9.49108646666265,10.7517773338189,10.4204391406193,9.31126148347887,12.9185991376651,14.0245345712806,10.9882513363091,8.71347105564652,11.9210331352411,9.8717246213606,9.56068028123673,10.9547442876569,13.3830507221948,14.3719191303676,12.0241115507247,11.779633031101,12.4354562956611,11.4116831778912,10.0820031717948,11.0271426572918,13.2722200138594,12.5340704035275,13.3536484418432,83642,"selenoprotein O","protein_coding",null,null,"GO:0005524,GO:0005694,GO:0005739,GO:0018117,GO:0046872,GO:0070733","ATP binding|chromosome|mitochondrion|protein adenylylation|metal ion binding|protein adenylyltransferase activity","WP15","Selenium micronutrient network"]
["SEMA4D",0.095496455751417,0.181665946938552,0.15294171946916,0.170602600178408,0.184800525205534,0.13715158833909,0.141507525421294,0.194631643909697,0.274985243841668,0.259695040955827,0.235968471113276,0.229832137432833,0.169167585381668,0.337399016804439,0.299520023129137,0.321346499113197,0.180027563850643,0.20963726208818,0.107296301682289,0.199868378374161,0.189105702419073,0.176206219385576,0.125701366886653,0.188424206622706,0.172647030244715,0.149452156951755,0.103281950577368,0.165472656168486,10507,"semaphorin 4D","protein_coding","hsa04360","Axon guidance","GO:0000122,GO:0001755,GO:0001934,GO:0004888,GO:0005102,GO:0005515,GO:0005615,GO:0005886,GO:0006955,GO:0007155,GO:0007162,GO:0007411,GO:0008360,GO:0010693,GO:0030215,GO:0030335,GO:0031344,GO:0038023,GO:0043066,GO:0043547,GO:0043931,GO:0045499,GO:0045668,GO:0048672,GO:0048814,GO:0048843,GO:0050731,GO:0050732,GO:0050919,GO:0051897,GO:0070486,GO:0071526,GO:1900220,GO:1905704","negative regulation of transcription by RNA polymerase II|neural crest cell migration|positive regulation of protein phosphorylation|transmembrane signaling receptor activity|signaling receptor binding|protein binding|extracellular space|plasma membrane|immune response|cell adhesion|negative regulation of cell adhesion|axon guidance|regulation of cell shape|negative regulation of alkaline phosphatase activity|semaphorin receptor binding|positive regulation of cell migration|regulation of cell projection organization|signaling receptor activity|negative regulation of apoptotic process|positive regulation of GTPase activity|ossification involved in bone maturation|chemorepellent activity|negative regulation of osteoblast differentiation|positive regulation of collateral sprouting|regulation of dendrite morphogenesis|negative regulation of axon extension involved in axon guidance|positive regulation of peptidyl-tyrosine phosphorylation|negative regulation of peptidyl-tyrosine phosphorylation|negative chemotaxis|positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction|leukocyte aggregation|semaphorin-plexin signaling pathway|semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis|positive regulation of inhibitory synapse assembly","WP5205","Clock-controlled autophagy in bone metabolism","R-HSA-1266738,R-HSA-373755,R-HSA-400685,R-HSA-416550,R-HSA-416572,R-HSA-416700,R-HSA-422475,R-HSA-9675108","Developmental Biology|Semaphorin interactions|Sema4D in semaphorin signaling|Sema4D mediated inhibition of cell attachment and migration|Sema4D induced cell migration and growth-cone collapse|Other semaphorin interactions|Axon guidance|Nervous system development"]
["SEPHS1",17.7748332907623,17.6498880700349,18.638448804465,16.9621344822283,16.4244336116352,15.1940062660424,19.957618373273,16.3716711757808,17.2876943063211,17.1349564896561,17.8902001439617,17.6722853975019,17.0568915359774,15.0265388941198,20.4103309095532,16.1965230028976,19.7918312647131,20.6195125157952,25.4792176167363,22.1809554378754,20.5472175264877,21.3128434636805,24.6319404871588,23.5815495429491,18.9558386773407,20.524273836067,24.5730843881857,21.934765988309,22929,"selenophosphate synthetase 1","protein_coding","hsa00450","Selenocompound metabolism","GO:0004756,GO:0005515,GO:0005524,GO:0005525,GO:0005737,GO:0005886,GO:0016260,GO:0016310,GO:0031965,GO:0036211,GO:0042802,GO:0046872","selenide, water dikinase activity|protein binding|ATP binding|GTP binding|cytoplasm|plasma membrane|selenocysteine biosynthetic process|phosphorylation|nuclear membrane|protein modification process|identical protein binding|metal ion binding"]
["SERHL2",0.915180146875538,1.88341983589421,1.31223865085962,1.64371337435569,1.05687106378087,1.42191768108094,1.49036476339457,1.20744158387827,1.30550325759717,1.6026105150892,1.59615908989757,1.45645476721325,1.10769044276033,1.69743287710852,0.727314247378166,1.40414458055313,1.40782443956209,0.923764317423155,0.645905789314673,0.704045310328522,0.926615759948504,0.806646099563616,0.673506463196356,1.26800479759173,0.940324697344791,0.869585749788809,1.28814984666389,1.54867541017829,253190,"serine hydrolase like 2","protein_coding",null,null,"GO:0003674,GO:0005575,GO:0005777,GO:0008150,GO:0016787,GO:0048471","molecular_function|cellular_component|peroxisome|biological_process|hydrolase activity|perinuclear region of cytoplasm"]
["SERTAD4",0.937178571765085,1.03685326738811,0.935426689555402,0.790005625024542,0.78563550736006,0.954168622563833,0.952613067544863,0.793237259228948,1.03694206244223,0.878869846975725,0.964859743702147,1.10664279312124,0.78336053426841,0.752408447549024,1.08716992909763,0.865203759967461,1.11918705758417,1.32352691773528,1.01204007349422,1.45142369307184,1.35476980338649,1.24715188355113,1.50466991875943,1.20955289088313,1.25678491354081,1.077959412364,1.20282317795532,1.1221874884366,56256,"SERTA domain containing 4","protein_coding",null,null,"GO:0005515,GO:0005634","protein binding|nucleus"]
["SETX",8.20084165165247,7.74998412048404,6.16973750191409,5.23390790951679,8.94301072807785,7.08826978372624,6.2321323224096,6.27382941468989,8.1871372647441,6.7701099782198,5.79576915314392,7.36618864368193,8.82441315135651,6.37234894848015,7.56171947120969,7.77564361035882,6.485302546741,6.3314591419737,5.4158099606591,6.15853529561076,6.83856738955702,5.79555465472292,6.99383744363322,6.91089138135613,6.88078890530464,5.31629999658688,5.74838387640855,5.38944884963022,23064,"senataxin","protein_coding","hsa05014","Amyotrophic lateral sclerosis","GO:0000165,GO:0000228,GO:0000781,GO:0001147,GO:0003677,GO:0003678,GO:0003723,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0006302,GO:0006310,GO:0006353,GO:0006369,GO:0006376,GO:0006396,GO:0006974,GO:0007283,GO:0007399,GO:0007623,GO:0008543,GO:0010976,GO:0016604,GO:0016787,GO:0030154,GO:0030424,GO:0030426,GO:0032508,GO:0033120,GO:0034599,GO:0042802,GO:0043066,GO:0043491,GO:0044344,GO:0045171,GO:0045944,GO:0060566,GO:0070301,GO:0071300,GO:2000144,GO:2000806","MAPK cascade|nuclear chromosome|chromosome, telomeric region|transcription termination site sequence-specific DNA binding|DNA binding|DNA helicase activity|RNA binding|protein binding|ATP binding|nucleus|nucleoplasm|nucleolus|cytoplasm|double-strand break repair|DNA recombination|DNA-templated transcription termination|termination of RNA polymerase II transcription|mRNA splice site recognition|RNA processing|DNA damage response|spermatogenesis|nervous system development|circadian rhythm|fibroblast growth factor receptor signaling pathway|positive regulation of neuron projection development|nuclear body|hydrolase activity|cell differentiation|axon|growth cone|DNA duplex unwinding|positive regulation of RNA splicing|cellular response to oxidative stress|identical protein binding|negative regulation of apoptotic process|phosphatidylinositol 3-kinase/protein kinase B signal transduction|cellular response to fibroblast growth factor stimulus|intercellular bridge|positive regulation of transcription by RNA polymerase II|positive regulation of termination of DNA-templated transcription|cellular response to hydrogen peroxide|cellular response to retinoic acid|positive regulation of DNA-templated transcription initiation|positive regulation of termination of RNA polymerase II transcription, poly(A)-coupled","WP2916,WP3594","Interactome of polycomb repressive complex 2 (PRC2) |Circadian rhythm genes"]
["SF3B2",69.674614340865,77.5458157129827,81.7798002912278,86.0042294109259,66.7640655535922,76.4576385069352,76.0179888180836,74.8200257550384,76.6899988792273,91.8153425249963,94.552536801737,82.3956984915694,66.6200062835322,75.3484362911139,72.7425760233375,68.2784963208513,67.652656616178,77.7036695963506,76.9694302986776,73.4434075222216,68.3805745058253,74.9674500233503,62.8605363533416,63.6715616342801,63.1689655340917,76.6129546036835,64.1811319555594,78.7109709651646,10992,"splicing factor 3b subunit 2","protein_coding","hsa03040","Spliceosome","GO:0000398,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005681,GO:0005684,GO:0005686,GO:0005689,GO:0006397,GO:0008380,GO:0016607,GO:0071005,GO:0071011,GO:0071013,GO:1903241","mRNA splicing, via spliceosome|RNA binding|protein binding|nucleus|nucleoplasm|spliceosomal complex|U2-type spliceosomal complex|U2 snRNP|U12-type spliceosomal complex|mRNA processing|RNA splicing|nuclear speck|U2-type precatalytic spliceosome|precatalytic spliceosome|catalytic step 2 spliceosome|U2-type prespliceosome assembly","WP411","mRNA processing","R-HSA-72163,R-HSA-72165,R-HSA-72172,R-HSA-72203,R-HSA-8953854","mRNA Splicing - Major Pathway|mRNA Splicing - Minor Pathway|mRNA Splicing|Processing of Capped Intron-Containing Pre-mRNA|Metabolism of RNA"]
["SGCZ",0,0.00349078734650408,0,0.00351975211517805,0,0,0,0,0.0295322515202376,0.0424162674109381,0.027611449438824,0.0553850079313976,0.0907437935409223,0.0489846582045403,0.0750879300625924,0.0347972590158569,0.0211709473861989,0.0169786498096835,0.0237433033512541,0.014116633488857,0.010391832546872,0.0244193509498295,0.0471003872384242,0.0215129891825796,0.00363853202369092,0.0104615056475613,0.0284112015193397,0.0172511649131811,137868,"sarcoglycan zeta","protein_coding",null,null,"GO:0005737,GO:0005856,GO:0016012,GO:0042383,GO:0046716,GO:0048738,GO:0055001,GO:0060047,GO:0061024","cytoplasm|cytoskeleton|sarcoglycan complex|sarcolemma|muscle cell cellular homeostasis|cardiac muscle tissue development|muscle cell development|heart contraction|membrane organization"]
["SH2D1A",0.0120555524307885,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4068,"SH2 domain containing 1A","protein_coding","hsa04650","Natural killer cell mediated cytotoxicity","GO:0002250,GO:0005515,GO:0005737,GO:0005829,GO:0006959,GO:0006968,GO:0007267,GO:0042267,GO:0045954,GO:0050776,GO:0050860","adaptive immune response|protein binding|cytoplasm|cytosol|humoral immune response|cellular defense response|cell-cell signaling|natural killer cell mediated cytotoxicity|positive regulation of natural killer cell mediated cytotoxicity|regulation of immune response|negative regulation of T cell receptor signaling pathway","WP5218,WP5072","Extrafollicular and follicular B cell activation by SARS-CoV-2|Modulators of TCR signaling and T cell activation","R-HSA-1280218,R-HSA-168256,R-HSA-198933","Adaptive Immune System|Immune System|Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"]
["SH3GLB1",14.6853022104844,14.2374772080913,14.426509316639,12.8437228532206,15.1051148948693,13.1111547299359,14.1903298643827,12.5093291961967,15.0061958221354,10.278045105842,12.6663849959392,13.6467113427293,14.562350169566,13.6249041336674,14.4721290531112,13.684455530197,15.1858649657235,13.3187277186571,15.3158846770941,15.2034539650605,14.4819172144626,14.5517568901697,17.1909059207904,15.367661573215,14.5555561346566,14.1645470069219,15.3622154300385,13.4641534402674,51100,"SH3 domain containing GRB2 like%2C endophilin B1","protein_coding","hsa04144,hsa04140","Endocytosis|Autophagy - animal","GO:0000139,GO:0000421,GO:0005515,GO:0005737,GO:0005741,GO:0005829,GO:0006914,GO:0006915,GO:0008289,GO:0010508,GO:0016020,GO:0016241,GO:0030496,GO:0031334,GO:0031410,GO:0031647,GO:0032465,GO:0032801,GO:0032991,GO:0034198,GO:0042149,GO:0042802,GO:0042803,GO:0045296,GO:0048102,GO:0061024,GO:0090148,GO:1903527,GO:1903778,GO:1903955,GO:2000786","Golgi membrane|autophagosome membrane|protein binding|cytoplasm|mitochondrial outer membrane|cytosol|autophagy|apoptotic process|lipid binding|positive regulation of autophagy|membrane|regulation of macroautophagy|midbody|positive regulation of protein-containing complex assembly|cytoplasmic vesicle|regulation of protein stability|regulation of cytokinesis|receptor catabolic process|protein-containing complex|cellular response to amino acid starvation|cellular response to glucose starvation|identical protein binding|protein homodimerization activity|cadherin binding|autophagic cell death|membrane organization|membrane fission|positive regulation of membrane tubulation|protein localization to vacuolar membrane|positive regulation of protein targeting to mitochondrion|positive regulation of autophagosome assembly","WP2509","Nanoparticle triggered autophagic cell death"]
["SHANK3",1.23649131567829,1.4575702275394,1.02526300385473,1.35479407915304,1.21857416393312,1.25044592405164,1.00901998854691,1.02941555472703,1.2543729277528,1.68625957935039,1.53721296072052,1.30426434081068,1.43050143169859,1.52141287501021,0.881285389781165,1.43959107266339,0.619807705282901,0.779018706263934,0.53069811417629,0.846891931649038,0.708218598279015,0.619476225718806,0.504273291232083,0.530013666450847,0.67057023014766,0.656063458805642,0.473839490446574,0.69879166562006,85358,"SH3 and multiple ankyrin repeat domains 3","protein_coding","hsa04724","Glutamatergic synapse","GO:0000165,GO:0003779,GO:0005515,GO:0005829,GO:0005886,GO:0007416,GO:0007612,GO:0007613,GO:0008270,GO:0014069,GO:0017124,GO:0021773,GO:0030160,GO:0030534,GO:0032232,GO:0035176,GO:0035255,GO:0042297,GO:0043005,GO:0043197,GO:0043621,GO:0044309,GO:0045211,GO:0045794,GO:0048170,GO:0048854,GO:0051835,GO:0051968,GO:0060170,GO:0060997,GO:0060999,GO:0061001,GO:0071625,GO:0097107,GO:0097110,GO:0097113,GO:0097114,GO:0097117,GO:1900271,GO:1900273,GO:1900451,GO:1900452,GO:2000463,GO:2000969","MAPK cascade|actin binding|protein binding|cytosol|plasma membrane|synapse assembly|learning|memory|zinc ion binding|postsynaptic density|SH3 domain binding|striatal medium spiny neuron differentiation|synaptic receptor adaptor activity|adult behavior|negative regulation of actin filament bundle assembly|social behavior|ionotropic glutamate receptor binding|vocal learning|neuron projection|dendritic spine|protein self-association|neuron spine|postsynaptic membrane|negative regulation of cell volume|positive regulation of long-term neuronal synaptic plasticity|brain morphogenesis|positive regulation of synapse structural plasticity|positive regulation of synaptic transmission, glutamatergic|ciliary membrane|dendritic spine morphogenesis|positive regulation of dendritic spine development|regulation of dendritic spine morphogenesis|vocalization behavior|postsynaptic density assembly|scaffold protein binding|AMPA glutamate receptor clustering|NMDA glutamate receptor clustering|guanylate kinase-associated protein clustering|regulation of long-term synaptic potentiation|positive regulation of long-term synaptic potentiation|positive regulation of glutamate receptor signaling pathway|regulation of long-term synaptic depression|positive regulation of excitatory postsynaptic potential|positive regulation of AMPA receptor activity","WP4312,WP5408,WP4539","Rett syndrome causing genes|15q25 copy number variation|Synaptic signaling pathways associated with autism spectrum disorder"]
["SHLD1",0.379429235354281,0.4298957726901,0.366698857102151,0.406705863327404,0.25080977556152,0.288186563845476,0.36962187583153,0.508856509555685,0.443392584503092,0.338568472717872,0.529999371479622,0.437875179658828,0.413897638309713,0.372378715082124,0.560435928957415,0.497310526647031,0.568656058320325,0.495631776187294,0.701353182826235,0.499009552201196,0.458189255153483,0.562207589940231,0.550853214442344,0.834056942956781,0.630646247029005,0.556694590011766,0.691137321993957,0.613746526003555,149840,"shieldin complex subunit 1","protein_coding",null,null,"GO:0000785,GO:0002208,GO:0005515,GO:0005694,GO:0006281,GO:0035861,GO:0043247,GO:0045830,GO:2000042,GO:2001034","chromatin|somatic diversification of immunoglobulins involved in immune response|protein binding|chromosome|DNA repair|site of double-strand break|telomere maintenance in response to DNA damage|positive regulation of isotype switching|negative regulation of double-strand break repair via homologous recombination|positive regulation of double-strand break repair via nonhomologous end joining","WP5402","10q22q23 copy number variation"]
["SIK1",0.0113571583042945,0,0.00533125335899513,0,0.00554886851071937,0,0,0.00556839701285818,0.0399831659972882,0.0109383991339562,0.0160211261950834,0,0.00540027842328008,0.00541383000560277,0.0158431405378442,0,0,0,0.010496527919285,0,0.0160792100393459,0.0161930963369193,0.00560600775009683,0.00554781635931632,0,0.026978357903707,0.0109901135011349,0,150094,"salt inducible kinase 1","protein_coding","hsa04922","Glucagon signaling pathway","GO:0000287,GO:0002028,GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0006468,GO:0007049,GO:0007346,GO:0008140,GO:0010830,GO:0010868,GO:0019901,GO:0032792,GO:0035556,GO:0042826,GO:0043153,GO:0043276,GO:0045595,GO:0045721,GO:0046777,GO:0048511,GO:0055007,GO:0071889,GO:0106310,GO:2000210","magnesium ion binding|regulation of sodium ion transport|protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|cytoplasm|protein phosphorylation|cell cycle|regulation of mitotic cell cycle|cAMP response element binding protein binding|regulation of myotube differentiation|negative regulation of triglyceride biosynthetic process|protein kinase binding|negative regulation of CREB transcription factor activity|intracellular signal transduction|histone deacetylase binding|entrainment of circadian clock by photoperiod|anoikis|regulation of cell differentiation|negative regulation of gluconeogenesis|protein autophosphorylation|rhythmic process|cardiac muscle cell differentiation|14-3-3 protein binding|protein serine kinase activity|positive regulation of anoikis","WP3594","Circadian rhythm genes","R-HSA-400253","Circadian Clock"]
["SKA1",7.87076775182461,5.59044044951823,2.02004947808556,5.75295821014959,5.45195121403266,3.41125477838552,1.67723971623383,3.69005009346761,4.90943067579735,3.4807770054059,2.05854494601409,3.7391004473437,3.79123430443432,1.06563031250572,0.822932719724593,1.23642092073274,6.65382124820676,5.88636412494831,3.78781754223434,6.88796229425352,6.43539545744751,6.06484800659745,3.71497387389174,6.0515193612141,6.53811767156841,7.03612167590002,3.71355707350271,4.8161985803748,220134,"spindle and kinetochore associated complex subunit 1","protein_coding",null,null,"GO:0000278,GO:0000776,GO:0000940,GO:0005515,GO:0005829,GO:0005876,GO:0007059,GO:0008017,GO:0015630,GO:0031110,GO:0034451,GO:0045171,GO:0051301,GO:0072686","mitotic cell cycle|kinetochore|outer kinetochore|protein binding|cytosol|spindle microtubule|chromosome segregation|microtubule binding|microtubule cytoskeleton|regulation of microtubule polymerization or depolymerization|centriolar satellite|intercellular bridge|cell division|mitotic spindle",null,null,"R-HSA-141424,R-HSA-141444,R-HSA-162582,R-HSA-1640170,R-HSA-194315,R-HSA-195258,R-HSA-2467813,R-HSA-2500257,R-HSA-2555396,R-HSA-5663220,R-HSA-68877,R-HSA-68882,R-HSA-68886,R-HSA-69278,R-HSA-69618,R-HSA-69620,R-HSA-9648025,R-HSA-9716542","Amplification of signal from the kinetochores|Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal|Signal Transduction|Cell Cycle|Signaling by Rho GTPases|RHO GTPase Effectors|Separation of Sister Chromatids|Resolution of Sister Chromatid Cohesion|Mitotic Metaphase and Anaphase|RHO GTPases Activate Formins|Mitotic Prometaphase|Mitotic Anaphase|M Phase|Cell Cycle, Mitotic|Mitotic Spindle Checkpoint|Cell Cycle Checkpoints|EML4 and NUDC in mitotic spindle formation|Signaling by Rho GTPases, Miro GTPases and RHOBTB3"]
["SKIV2L",13.0419793618093,15.0865494552277,14.589622764975,16.1151982709413,13.5145816779712,13.6755819927967,12.9623250365328,14.8622491086518,14.8240741076527,18.9794221932987,17.068944344724,15.2625674035515,14.4931674188139,16.5253524139024,14.2899878047449,14.9328838437252,12.9550295587712,14.6176197761953,14.0142519007733,15.0779157504722,13.7520825781815,14.4928771128064,12.4344168820672,13.3279502261853,12.791757119649,13.4995037782384,12.5394535002357,15.4623356675745,6499,"Ski2 like RNA helicase","protein_coding","hsa03018","RNA degradation","GO:0003723,GO:0003724,GO:0005515,GO:0005524,GO:0005634,GO:0005829,GO:0016887,GO:0034458,GO:0055087,GO:0070478,GO:0072344","RNA binding|RNA helicase activity|protein binding|ATP binding|nucleus|cytosol|ATP hydrolysis activity|3'-5' RNA helicase activity|Ski complex|nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay|rescue of stalled ribosome",null,null,"R-HSA-390466,R-HSA-390471,R-HSA-391251,R-HSA-392499,R-HSA-429914,R-HSA-429958,R-HSA-8953854","Chaperonin-mediated protein folding|Association of TriC/CCT with target proteins during biosynthesis|Protein folding|Metabolism of proteins|Deadenylation-dependent mRNA decay|mRNA decay by 3' to 5' exoribonuclease|Metabolism of RNA"]
["SLC12A5-AS1",0.0137883453888711,0.0131150041227992,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.0132566588705568,0,0,0,0,0,0,0,0,0,0,0.0259252800587857,109729184,"SLC12A5 and MMP9 antisense RNA 1","non_coding"]
["SLC16A2",17.2133196124275,16.4783132529971,12.1142297377946,14.0347941327246,15.2759462926359,15.9372970601988,10.320721830811,12.4417805098676,16.4735127071128,19.6603971939765,17.0171902970911,17.3245995340177,17.1956521121451,17.3259622661937,17.6236951197021,17.3238676643694,9.83807548451254,11.232195345063,8.50970148090034,10.2292629770677,9.72590438223442,10.5210210745921,7.52322573342809,9.60147863561053,10.1772596527188,9.53671750277108,7.70923981633513,9.26381287245924,6567,"solute carrier family 16 member 2","protein_coding","hsa04919","Thyroid hormone signaling pathway","GO:0005886,GO:0006520,GO:0006590,GO:0008028,GO:0015171,GO:0015349,GO:0015718,GO:0016324,GO:0042403,GO:0042802,GO:0070327,GO:0070460,GO:0089718,GO:0150104,GO:2000178","plasma membrane|amino acid metabolic process|thyroid hormone generation|monocarboxylic acid transmembrane transporter activity|amino acid transmembrane transporter activity|thyroid hormone transmembrane transporter activity|monocarboxylic acid transport|apical plasma membrane|thyroid hormone metabolic process|identical protein binding|thyroid hormone transport|thyroid-stimulating hormone secretion|amino acid import across plasma membrane|transport across blood-brain barrier|negative regulation of neural precursor cell proliferation","WP4746,WP3915","Thyroid hormones production and peripheral downstream signaling effects|Angiopoietin-like protein 8 regulatory pathway","R-HSA-382551,R-HSA-425397,R-HSA-425407,R-HSA-879518","Transport of small molecules|Transport of vitamins, nucleosides, and related molecules|SLC-mediated transmembrane transport|Transport of organic anions"]
["SLC22A15",1.52682990078423,1.70911081120196,1.37397660229666,1.35561385323481,1.74604212808883,1.54333874471968,1.25345187596589,1.49066662907955,0.932200712677598,0.459140182940347,0.388757666335212,0.576882644241502,0.928900649377442,0.772318402410699,0.644865064378534,0.796532755414422,1.04808102474201,0.946955531427224,0.699402244215687,1.02583896092658,1.28377558344316,1.18829811265391,0.951123760849133,1.07152786554228,1.38814091514768,1.13717014899416,0.90649204365313,0.88380324939458,55356,"solute carrier family 22 member 15","protein_coding",null,null,"GO:0003674,GO:0005575,GO:0005886,GO:0006811,GO:0008150,GO:0015199,GO:0015838,GO:0055085","molecular_function|cellular_component|plasma membrane|monoatomic ion transport|biological_process|amino-acid betaine transmembrane transporter activity|amino-acid betaine transport|transmembrane transport",null,null,"R-HSA-382551,R-HSA-425366,R-HSA-425407,R-HSA-549127,R-HSA-549132","Transport of small molecules|Transport of bile salts and organic acids, metal ions and amine compounds|SLC-mediated transmembrane transport|Organic cation transport|Organic cation/anion/zwitterion transport"]
["SLC25A10",5.38150277054085,4.38911324741079,3.40633378010599,4.56565424607916,4.44956597959527,3.715812755438,2.56724418084736,3.95184407643745,3.31886850664947,5.57004874146857,4.35107929814261,4.45878498961836,2.75571768686717,2.51887121722737,2.93265786306608,2.22800688446221,6.08704580298467,6.56773898850853,6.21149818295644,5.49108509773963,6.17105411028127,5.7402649265933,4.49538519753903,5.81664489702027,5.34741772687731,6.66361053496701,4.67739776639236,6.21530486124771,1468,"solute carrier family 25 member 10","protein_coding","hsa04964","Proximal tubule bicarbonate reclamation","GO:0005310,GO:0005515,GO:0005634,GO:0005654,GO:0005739,GO:0005743,GO:0006094,GO:0006811,GO:0006835,GO:0006839,GO:0006869,GO:0008272,GO:0015114,GO:0015116,GO:0015117,GO:0015131,GO:0015140,GO:0015141,GO:0015297,GO:0015709,GO:0015729,GO:0035435,GO:0070221,GO:0071422,GO:0071423,GO:1902356,GO:1902358","dicarboxylic acid transmembrane transporter activity|protein binding|nucleus|nucleoplasm|mitochondrion|mitochondrial inner membrane|gluconeogenesis|monoatomic ion transport|dicarboxylic acid transport|mitochondrial transport|lipid transport|sulfate transport|phosphate ion transmembrane transporter activity|sulfate transmembrane transporter activity|thiosulfate transmembrane transporter activity|oxaloacetate transmembrane transporter activity|malate transmembrane transporter activity|succinate transmembrane transporter activity|antiporter activity|thiosulfate transport|oxaloacetate transport|phosphate ion transmembrane transport|sulfide oxidation, using sulfide:quinone oxidoreductase|succinate transmembrane transport|malate transmembrane transport|oxaloacetate(2-) transmembrane transport|sulfate transmembrane transport",null,null,"R-HSA-1430728,R-HSA-1614517,R-HSA-1614558,R-HSA-1614635,R-HSA-382551,R-HSA-425393,R-HSA-425407,R-HSA-428643,R-HSA-70263,R-HSA-70326,R-HSA-71291,R-HSA-71387","Metabolism|Sulfide oxidation to sulfate|Degradation of cysteine and homocysteine|Sulfur amino acid metabolism|Transport of small molecules|Transport of inorganic cations/anions and amino acids/oligopeptides|SLC-mediated transmembrane transport|Organic anion transporters|Gluconeogenesis|Glucose metabolism|Metabolism of amino acids and derivatives|Metabolism of carbohydrates"]
["SLC25A21-AS1",0.502857604727542,0.710204533602913,0.486406800245956,0.277670438911064,0.536041400527899,0.686849333645097,0.796153025103377,1.13562562302028,0.70506372393603,0.410935064807497,0.472908505669119,0.536578138834145,0.840495792633133,0.886187966779184,0.623539679264829,0.982466873265115,0.498117645633641,0.366581430656334,0.661919120278059,0.380985514042825,0.474623013354734,1.01390691196437,0.857472001703477,0.58060140534161,0.604296613092365,0.839778786681293,0.648808091225283,0.759256046718791,100129794,"SLC25A21 antisense RNA 1","non_coding"]
["SLC25A5",147.588887699617,129.101561873249,153.335710272296,147.223219300359,117.353181462204,125.171842538304,153.420195572261,142.682547264244,111.755719683509,108.894625606922,116.10532626465,119.830994685236,105.129496694464,108.047806768245,117.347309512519,100.14194547218,152.843495373116,166.557462881921,196.63944836528,163.145863025581,146.757681157364,167.891592159769,176.671678606205,164.984655777995,143.664861865825,175.706523597725,200.717055019089,179.352059396735,292,"solute carrier family 25 member 5","protein_coding","hsa04020,hsa04022,hsa04217,hsa04218,hsa04613,hsa05208,hsa05166,hsa05164,hsa05010,hsa05012,hsa05016,hsa05017,hsa05020,hsa05022,hsa05415","Calcium signaling pathway|cGMP-PKG signaling pathway|Necroptosis|Cellular senescence|Neutrophil extracellular trap formation|Chemical carcinogenesis - reactive oxygen species|Human T-cell leukemia virus 1 infection|Influenza A|Alzheimer disease|Parkinson disease|Huntington disease|Spinocerebellar ataxia|Prion disease|Pathways of neurodegeneration - multiple diseases|Diabetic cardiomyopathy","GO:0000295,GO:0003723,GO:0005471,GO:0005515,GO:0005634,GO:0005739,GO:0005743,GO:0005757,GO:0005886,GO:0007059,GO:0008284,GO:0015078,GO:0015207,GO:0015853,GO:0016020,GO:0017077,GO:0030183,GO:0030218,GO:0031625,GO:0042645,GO:0046902,GO:0051503,GO:0071817,GO:0140021,GO:1901029,GO:1901526,GO:1902600,GO:1990544,GO:1990830,GO:1990845","adenine nucleotide transmembrane transporter activity|RNA binding|ATP:ADP antiporter activity|protein binding|nucleus|mitochondrion|mitochondrial inner membrane|mitochondrial permeability transition pore complex|plasma membrane|chromosome segregation|positive regulation of cell population proliferation|proton transmembrane transporter activity|adenine transmembrane transporter activity|adenine transport|membrane|oxidative phosphorylation uncoupler activity|B cell differentiation|erythrocyte differentiation|ubiquitin protein ligase binding|mitochondrial nucleoid|regulation of mitochondrial membrane permeability|adenine nucleotide transport|MMXD complex|mitochondrial ADP transmembrane transport|negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway|positive regulation of mitophagy|proton transmembrane transport|mitochondrial ATP transmembrane transport|cellular response to leukemia inhibitory factor|adaptive thermogenesis","WP5124,WP2059,WP111,WP5356,WP5355","Alzheimer's disease|Alzheimer's disease and miRNA effects|Electron transport chain: OXPHOS system in mitochondria|Disturbed pathways in Duchenne Muscular Dystrophy|Metabolic Epileptic Disorders","R-HSA-162906,R-HSA-162909,R-HSA-1643685,R-HSA-176033,R-HSA-180897,R-HSA-382551,R-HSA-425397,R-HSA-425407,R-HSA-5663205,R-HSA-83936,R-HSA-9824446","HIV Infection|Host Interactions of HIV factors|Disease|Interactions of Vpr with host cellular proteins|Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization|Transport of small molecules|Transport of vitamins, nucleosides, and related molecules|SLC-mediated transmembrane transport|Infectious disease|Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane|Viral Infection Pathways"]
["SLC28A3",0.0531927636679202,0.0297618491701364,0.0264384372903481,0.0240070382226189,0.0336326485228361,0.0264444966167624,0.0116772630910196,0.0214779180894097,0.00944200757760355,0.0241089173250795,0,0.00944405997112281,0.0535614846379094,0.00894931550897145,0.00581987913585966,0.00296675412038849,0.0330916365654468,0.00579028126997683,0.0173512541031385,0.0180533963393479,0.0059065977989379,0.0237937328880189,0.00308899811836444,0.0336262712518189,0.0248171957878211,0.014865497965049,0.0121114495159344,0.0205912627744911,64078,"solute carrier family 28 member 3","protein_coding",null,null,"GO:0005345,GO:0005415,GO:0005789,GO:0005886,GO:0006805,GO:0006855,GO:0015213,GO:0015389,GO:0015390,GO:0015855,GO:0015860,GO:0015862,GO:0015864,GO:0031526,GO:0035725,GO:0072531,GO:1901642,GO:1904823","purine nucleobase transmembrane transporter activity|nucleoside:sodium symporter activity|endoplasmic reticulum membrane|plasma membrane|xenobiotic metabolic process|xenobiotic transmembrane transport|uridine transmembrane transporter activity|pyrimidine- and adenosine-specific:sodium symporter activity|purine-specific nucleoside:sodium symporter activity|pyrimidine nucleobase transport|purine nucleoside transmembrane transport|uridine transport|pyrimidine nucleoside transport|brush border membrane|sodium ion transmembrane transport|pyrimidine-containing compound transmembrane transport|nucleoside transmembrane transport|purine nucleobase transmembrane transport",null,null,"R-HSA-382551,R-HSA-425397,R-HSA-425407,R-HSA-83936,R-HSA-9748784,R-HSA-9748787,R-HSA-9755088","Transport of small molecules|Transport of vitamins, nucleosides, and related molecules|SLC-mediated transmembrane transport|Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane|Drug ADME|Azathioprine ADME|Ribavirin ADME"]
["SLC30A1",8.064450612546,6.98753977506813,5.70308950876617,4.72918385716773,8.12161038802635,6.35730943988243,5.93645314555511,5.84463504970461,6.71760999549407,3.83729083489083,3.94048837717201,4.65272600228443,8.46963887694377,5.22885487746123,7.68707225276292,7.32537807838641,5.26427480163762,4.61333511993271,6.34992203337307,7.28868221282286,6.11781154196788,5.21762282785381,9.60514608276132,7.80277541386388,5.58717492341085,4.88968430646562,6.83000306658718,4.70888300982895,7779,"solute carrier family 30 member 1","protein_coding","hsa04978","Mineral absorption","GO:0001701,GO:0005385,GO:0005515,GO:0005737,GO:0005783,GO:0005794,GO:0005886,GO:0006829,GO:0006874,GO:0006882,GO:0010312,GO:0016323,GO:0019855,GO:0030315,GO:0030659,GO:0031965,GO:0042742,GO:0046872,GO:0046929,GO:0062111,GO:0070509,GO:0070574,GO:0071577,GO:0071584,GO:0071585,GO:0090281,GO:0098685,GO:0098839,GO:0140826,GO:0140882","in utero embryonic development|zinc ion transmembrane transporter activity|protein binding|cytoplasm|endoplasmic reticulum|Golgi apparatus|plasma membrane|zinc ion transport|intracellular calcium ion homeostasis|intracellular zinc ion homeostasis|detoxification of zinc ion|basolateral plasma membrane|calcium channel inhibitor activity|T-tubule|cytoplasmic vesicle membrane|nuclear membrane|defense response to bacterium|metal ion binding|negative regulation of neurotransmitter secretion|zinc ion import into organelle|calcium ion import|cadmium ion transmembrane transport|zinc ion transmembrane transport|negative regulation of zinc ion transmembrane import|detoxification of cadmium ion|negative regulation of calcium ion import|Schaffer collateral - CA1 synapse|postsynaptic density membrane|zinc:proton antiporter activity|zinc export across plasma membrane","WP3529","Zinc homeostasis","R-HSA-382551,R-HSA-425366,R-HSA-425407,R-HSA-425410,R-HSA-435354,R-HSA-435368","Transport of small molecules|Transport of bile salts and organic acids, metal ions and amine compounds|SLC-mediated transmembrane transport|Metal ion SLC transporters|Zinc transporters|Zinc efflux and compartmentalization by the SLC30 family"]
["SLC35B2",61.0250460203619,55.1682793824709,52.5901357567504,54.0668576109511,55.2858032181292,58.3046880220548,57.448852604941,61.1655594125753,58.3528559939331,74.6861984321131,61.2465416688598,62.2140817467519,59.5348701612423,65.3711978474131,60.7217670337393,61.5559577045476,63.9816620699876,66.0206779108062,69.790969603878,62.1315374094696,63.2963985836671,64.0515089122122,58.0855343161645,62.0256128126429,66.5458866803394,65.856160025691,63.622035109619,65.4170982171585,347734,"solute carrier family 35 member B2","protein_coding",null,null,"GO:0000139,GO:0005515,GO:0005794,GO:0015297,GO:0016020,GO:0030206,GO:0043123,GO:0046963,GO:0046964,GO:1902558,GO:1902559","Golgi membrane|protein binding|Golgi apparatus|antiporter activity|membrane|chondroitin sulfate biosynthetic process|positive regulation of canonical NF-kappaB signal transduction|3'-phosphoadenosine 5'-phosphosulfate transport|3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity|5'-adenylyl sulfate transmembrane transport|3'-phospho-5'-adenylyl sulfate transmembrane transport","WP4784","Proteoglycan biosynthesis","R-HSA-1430728,R-HSA-156580,R-HSA-156584,R-HSA-1630316,R-HSA-174362,R-HSA-211859,R-HSA-382551,R-HSA-425397,R-HSA-425407,R-HSA-71387,R-HSA-727802","Metabolism|Phase II - Conjugation of compounds|Cytosolic sulfonation of small molecules|Glycosaminoglycan metabolism|Transport and synthesis of PAPS|Biological oxidations|Transport of small molecules|Transport of vitamins, nucleosides, and related molecules|SLC-mediated transmembrane transport|Metabolism of carbohydrates|Transport of nucleotide sugars"]
["SLC37A1",0.0302905003075599,0.042108810453918,0.0175001882238049,0.0178771401407089,0.0478131260461649,0.0218802487829936,0.0173912389193765,0.015993799320621,0.0984355202640474,0.123426914075933,0.0876506595765247,0.0375073969637124,0.0487486106713486,0.106627508838847,0.0758422965009977,0.0552307605392577,0.0134411451769065,0.0237149280209765,0.0193812413473773,0.0112030721081829,0.010996054118301,0.0110739372909436,2.30026093782605E-3,0.0341457570978579,0.00693016277483184,0.0221395565682249,0.00901894179097374,0.0197145519333708,54020,"solute carrier family 37 member 1","protein_coding",null,null,"GO:0005789,GO:0008643,GO:0015760,GO:0016020,GO:0035435,GO:0061513","endoplasmic reticulum membrane|carbohydrate transport|glucose-6-phosphate transport|membrane|phosphate ion transmembrane transport|glucose 6-phosphate:inorganic phosphate antiporter activity",null,null,"R-HSA-1430728,R-HSA-70263,R-HSA-70326,R-HSA-71387","Metabolism|Gluconeogenesis|Glucose metabolism|Metabolism of carbohydrates"]
["SLC41A2",0.416096118904727,0.467525390696394,0.454611344948079,0.319715053455465,0.515967133419706,0.466140549077203,0.351889811721785,0.341211845880611,0.269233871364145,0.192174382401561,0.226550409783897,0.291325408361784,0.351736639704568,0.285343245847747,0.294185486468949,0.431436696309484,0.35326159793128,0.290437905541149,0.249629852033125,0.339288851360127,0.362876138562028,0.333065008028985,0.410778472020252,0.387496293013265,0.340154134110434,0.291322429790234,0.339072481754098,0.205883418773395,84102,"solute carrier family 41 member 2","protein_coding",null,null,"GO:0005515,GO:0005886,GO:0006824,GO:0006826,GO:0006828,GO:0015095,GO:0015675,GO:0015693,GO:1903830","protein binding|plasma membrane|cobalt ion transport|iron ion transport|manganese ion transport|magnesium ion transmembrane transporter activity|nickel cation transport|magnesium ion transport|magnesium ion transmembrane transport",null,null,"R-HSA-382551,R-HSA-425366,R-HSA-425407,R-HSA-425410","Transport of small molecules|Transport of bile salts and organic acids, metal ions and amine compounds|SLC-mediated transmembrane transport|Metal ion SLC transporters"]
["SLC44A3-AS1",0.0722202685472019,0.103040186443694,0.113004955102254,0.103895161229669,0.14702209656388,0.192152452283889,0.123531573657119,0.135736359513478,0.223985050636229,0.179689886286625,0.14715780585321,0.169539044893521,0.103021252546459,0.195084022157686,0.151120002946711,0.142657885393764,0.0810079824262425,0.0334114354593773,0.0333737562175795,0.0289368924357153,0.0795260951696696,0.0800893649147123,0.0475315361280815,0.0235190750235986,0.107401276814507,0.0629037247000612,0.046590818298627,0.0735533593094484,101928079,"SLC44A3 antisense RNA 1","non_coding"]
["SLC52A2",28.5672839673624,24.3739426448069,23.7620496401407,27.6552060789854,23.8878140536534,24.2388988546935,22.8298837943985,24.8075800795244,22.2175195426238,32.5624914844144,26.1412578432847,24.1368536189206,22.0490912287426,21.9486000191286,17.306276408869,19.6034028277163,25.9055438528342,26.0650363986297,28.5496513024926,24.215261326168,25.674067191033,26.7658627814337,21.1487674227445,23.9631236142807,25.7412037228055,28.0647596683681,23.9272857724083,28.6016245287781,79581,"solute carrier family 52 member 2","protein_coding",null,null,"GO:0001618,GO:0005515,GO:0005886,GO:0006771,GO:0032217,GO:0032218,GO:0046718,GO:0062124","virus receptor activity|protein binding|plasma membrane|riboflavin metabolic process|riboflavin transmembrane transporter activity|riboflavin transport|viral entry into host cell|4-hydroxybutyrate receptor activity","WP5037","Riboflavin and CoQ disorders","R-HSA-1430728,R-HSA-196843,R-HSA-196849,R-HSA-196854","Metabolism|Vitamin B2 (riboflavin) metabolism|Metabolism of water-soluble vitamins and cofactors|Metabolism of vitamins and cofactors"]
["SLC6A8",15.7718973612416,19.4544224013569,18.1962207100034,19.2497341913268,17.5646820258168,18.8544479332924,18.4266014838146,18.893977799714,17.3800968799271,22.0018316434539,21.6347496956596,19.1290001749749,17.1707547917111,20.6425652674077,18.4047893940743,18.6688807544377,8.85999326571615,10.1191782657153,8.05278887710969,9.15147591915564,8.98868987997798,10.6693019502967,6.33391965230854,7.98897547294923,9.38861491866085,9.1825898310618,6.54556142581198,8.83977977775853,6535,"solute carrier family 6 member 8","protein_coding",null,null,"GO:0003674,GO:0005308,GO:0005309,GO:0005332,GO:0005886,GO:0006600,GO:0006836,GO:0006936,GO:0015812,GO:0015881,GO:0016020,GO:0016324,GO:0035725,GO:0071705","molecular_function|creatine transmembrane transporter activity|creatine:sodium symporter activity|gamma-aminobutyric acid:sodium:chloride symporter activity|plasma membrane|creatine metabolic process|neurotransmitter transport|muscle contraction|gamma-aminobutyric acid transport|creatine transmembrane transport|membrane|apical plasma membrane|sodium ion transmembrane transport|nitrogen compound transport","WP2882,WP2884,WP5190","Nuclear receptors meta-pathway|NRF2 pathway|Creatine pathway","R-HSA-1430728,R-HSA-71288,R-HSA-71291","Metabolism|Creatine metabolism|Metabolism of amino acids and derivatives"]
["SLC9A3-AS1",4.02376725733707,5.12221131839833,6.40497436729101,6.89111961887868,4.15357718772623,5.53993901719848,4.78440960976099,5.02853436037756,1.36940901146556,1.98140936411028,2.30461472872912,2.23718757346236,0.906292180440272,1.81713290157752,1.32238954068757,1.37689356213586,2.60331172191751,3.90500370547061,2.72622573412037,3.46204098880554,2.58424426118149,2.61692674011725,2.40431353823976,2.17245577209773,2.51953028953628,3.21962327194534,2.56166162688842,2.97220533266541,100288152,"SLC9A3 antisense RNA 1","non_coding"]
["SLC9A9",0.323251245598685,0.508715754598626,0.427630682737188,0.394566782954059,0.450829082612059,0.518793507642486,0.526412496827474,0.481232003002978,0.47589687634906,0.546246815270674,0.621816358182119,0.51147860607804,0.687478462021846,0.630369179465189,0.677765625822898,0.766228208379526,0.175170568156567,0.149546496388682,0.192833221428762,0.141293296870782,0.127587792529221,0.139664646810124,0.232087376341085,0.178000656707274,0.171893169642056,0.201041558438037,0.159245822099297,0.234826851290129,285195,"solute carrier family 9 member A9","protein_coding",null,null,"GO:0005515,GO:0005769,GO:0005886,GO:0006811,GO:0015385,GO:0015386,GO:0030670,GO:0031901,GO:0031902,GO:0032009,GO:0042742,GO:0051453,GO:0055037,GO:0055038,GO:0071805,GO:0090382,GO:0098719,GO:1902600","protein binding|early endosome|plasma membrane|monoatomic ion transport|sodium:proton antiporter activity|potassium:proton antiporter activity|phagocytic vesicle membrane|early endosome membrane|late endosome membrane|early phagosome|defense response to bacterium|regulation of intracellular pH|recycling endosome|recycling endosome membrane|potassium ion transmembrane transport|phagosome maturation|sodium ion import across plasma membrane|proton transmembrane transport",null,null,"R-HSA-1643685,R-HSA-382551,R-HSA-425393,R-HSA-425407,R-HSA-425986,R-HSA-5619052,R-HSA-5619102,R-HSA-5619115","Disease|Transport of small molecules|Transport of inorganic cations/anions and amino acids/oligopeptides|SLC-mediated transmembrane transport|Sodium/Proton exchangers|Defective SLC9A9 causes autism 16 (AUTS16)|SLC transporter disorders|Disorders of transmembrane transporters"]
["SLX1B",0,0,0,0,0.045219706129416,0,0,0.317651955948952,0.0232740759030199,0,0,0,0,0,0,0,0.0222461528686168,0,0,0,0.0218392017329828,0,0.0228426770727121,0,0,0,0,0.0435055128883485,79008,"SLX1 homolog B%2C structure-specific endonuclease subunit","protein_coding","hsa03460","Fanconi anemia pathway","GO:0000724,GO:0005515,GO:0005654,GO:0006281,GO:0008821,GO:0010792,GO:0010833,GO:0017108,GO:0033557,GO:0046872,GO:0061820,GO:0090656,GO:1904357,GO:1904431","double-strand break repair via homologous recombination|protein binding|nucleoplasm|DNA repair|crossover junction DNA endonuclease activity|DNA double-strand break processing involved in repair via single-strand annealing|telomere maintenance via telomere lengthening|5'-flap endonuclease activity|Slx1-Slx4 complex|metal ion binding|telomeric D-loop disassembly|t-circle formation|negative regulation of telomere maintenance via telomere lengthening|positive regulation of t-circle formation",null,null,"R-HSA-5685942,R-HSA-5693532,R-HSA-5693537,R-HSA-5693538,R-HSA-5693567,R-HSA-5693568,R-HSA-6783310,R-HSA-73894","HDR through Homologous Recombination (HRR)|DNA Double-Strand Break Repair|Resolution of D-Loop Structures|Homology Directed Repair|HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)|Resolution of D-loop Structures through Holliday Junction Intermediates|Fanconi Anemia Pathway|DNA Repair"]
["SMARCA1",27.100051455271,24.4333990038867,20.8696005247416,22.0966503526081,27.7395971472498,23.4898210186795,22.4781473038356,22.5993115900153,34.4995414863297,22.9145705950608,25.4306940815571,29.6263268847205,36.3169405058183,30.3120131920853,31.6054655603602,31.9063900042602,35.1696137459123,29.02497508244,29.9650960980941,31.7246514573827,35.4272055732836,28.7550443202074,36.1514035753489,39.0209734004691,37.2905716489689,27.5390614895523,35.2461136585573,31.3224920126198,6594,"SWI/SNF related%2C matrix associated%2C actin dependent regulator of chromatin%2C subfamily a%2C member 1","protein_coding","hsa03082","ATP-dependent chromatin remodeling","GO:0003677,GO:0004386,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0006338,GO:0006355,GO:0007420,GO:0008094,GO:0016589,GO:0016787,GO:0030182,GO:0031491,GO:0036310,GO:0043231,GO:0045893,GO:0045944,GO:0061629,GO:0090537,GO:0140658,GO:1904949","DNA binding|helicase activity|protein binding|ATP binding|nucleus|nucleoplasm|chromatin remodeling|regulation of DNA-templated transcription|brain development|ATP-dependent activity, acting on DNA|NURF complex|hydrolase activity|neuron differentiation|nucleosome binding|ATP-dependent DNA/DNA annealing activity|intracellular membrane-bounded organelle|positive regulation of DNA-templated transcription|positive regulation of transcription by RNA polymerase II|RNA polymerase II-specific DNA-binding transcription factor binding|CERF complex|ATP-dependent chromatin remodeler activity|ATPase complex","WP2882,WP4312","Nuclear receptors meta-pathway|Rett syndrome causing genes"]
["SMDT1",13.6161676188263,10.9486355000437,18.9076859566196,15.8392563231021,11.2309595994726,14.3420198067126,18.0010206257316,18.9364462956609,13.4009208614968,13.1307358336181,16.7814903486332,16.7027048097474,13.0965602412918,16.0909494966653,17.1728351050932,15.0700757964931,17.2889067553137,19.8479220595637,22.8081420572887,16.8109154488378,19.0901467747632,20.7345168983257,18.7576839868568,18.1414731506132,18.2387124731975,21.1530706542736,22.7951805051845,21.1399331104189,91689,"single-pass membrane protein with aspartate rich tail 1","protein_coding",null,null,"GO:0005515,GO:0005654,GO:0005739,GO:0005743,GO:0005759,GO:0006851,GO:0036444,GO:0051560,GO:1990246","protein binding|nucleoplasm|mitochondrion|mitochondrial inner membrane|mitochondrial matrix|mitochondrial calcium ion transmembrane transport|calcium import into the mitochondrion|mitochondrial calcium ion homeostasis|uniplex complex",null,null,"R-HSA-382551,R-HSA-8949215,R-HSA-8949664","Transport of small molecules|Mitochondrial calcium ion transport|Processing of SMDT1"]
["SMILR",0.0473747192183534,0,0.0444770820652897,0.18174045192255,0,0.0889745512022684,0,0.185822007873728,0.047652545565937,0,0,0,0.0450529379179447,0,0.0440582238624174,0,0.36438338266346,0.0876683183494734,0.043784725863661,0,0,0,0.0935385546211236,0,0,0.180058017530962,0.0916872913706284,0.044537717499935,105375734,"smooth muscle induced lncRNA%2C enhancer of proliferation","non_coding"]
["SMIM45",0.119846374164897,0.131531291347841,0.103860983701025,0.167988716290585,0.090083716895981,0.0952277216099518,0.0344047953246011,0.189841584480435,0.111276190534958,0.115427419452047,0.190737607507677,0.120575409993832,0.131507122137366,0.105469703296565,0.0943093102444838,0.0524458004387419,0.0620442464581293,0.051179828803882,0.12780527881202,0.079786256564714,0.0870132353588407,0.131444302857996,0.154719295289009,0.0990732991909782,0.063979180573895,0.078836962019157,0.151657176714789,0.268673323865032,339674,"small integral membrane protein 45","protein_coding",null,null,"GO:0005634,GO:0005737,GO:0007399,GO:0016020","nucleus|cytoplasm|nervous system development|membrane"]
["SMTNL2",0,0,0,0,0.00871912572670799,0,0,0.00874981152599729,0,0,0,0,0,0,0,0,0.00857887060309122,0,0,0,0,0,0,0,0,0,0,0,342527,"smoothelin like 2","protein_coding",null,null,"GO:0005815,GO:0030036,GO:0031941","microtubule organizing center|actin cytoskeleton organization|filamentous actin"]
["SNAPIN",31.498189686645,30.829151216797,32.4228172564981,35.440973597434,28.4676760132574,31.9002596298557,35.2299272802674,34.1549372717537,34.3321625147688,29.8191011732808,34.272814849176,32.0413038656362,30.082291337827,29.5940836961802,31.2926719650048,29.4318720767245,46.3039366109212,39.9613259907012,49.2557212159193,43.3406157976504,47.6130524681179,45.0635627588011,47.0679851774127,48.5486643992426,43.4847745855075,46.349007162223,52.4561459367912,49.7238083296981,23557,"SNAP associated protein","protein_coding",null,null,"GO:0000139,GO:0000149,GO:0001669,GO:0002177,GO:0005515,GO:0005829,GO:0006886,GO:0007040,GO:0007042,GO:0007269,GO:0008021,GO:0008089,GO:0008090,GO:0008333,GO:0010977,GO:0016079,GO:0016188,GO:0030141,GO:0030672,GO:0031083,GO:0031175,GO:0031503,GO:0031629,GO:0032418,GO:0032438,GO:0043393,GO:0045202,GO:0048471,GO:0048489,GO:0048490,GO:0051036,GO:0051604,GO:0062196,GO:0070050,GO:0072384,GO:0072553,GO:0097352,GO:0098574,GO:0099078,GO:1902774,GO:1902824,GO:1904115,GO:2000300","Golgi membrane|SNARE binding|acrosomal vesicle|manchette|protein binding|cytosol|intracellular protein transport|lysosome organization|lysosomal lumen acidification|neurotransmitter secretion|synaptic vesicle|anterograde axonal transport|retrograde axonal transport|endosome to lysosome transport|negative regulation of neuron projection development|synaptic vesicle exocytosis|synaptic vesicle maturation|secretory granule|synaptic vesicle membrane|BLOC-1 complex|neuron projection development|protein-containing complex localization|synaptic vesicle fusion to presynaptic active zone membrane|lysosome localization|melanosome organization|regulation of protein binding|synapse|perinuclear region of cytoplasm|synaptic vesicle transport|anterograde synaptic vesicle transport|regulation of endosome size|protein maturation|regulation of lysosome size|neuron cellular homeostasis|organelle transport along microtubule|terminal button organization|autophagosome maturation|cytoplasmic side of lysosomal membrane|BORC complex|late endosome to lysosome transport|positive regulation of late endosome to lysosome transport|axon cytoplasm|regulation of synaptic vesicle exocytosis","WP5202","Alstrom syndrome","R-HSA-199991,R-HSA-199992,R-HSA-432722,R-HSA-5653656","Membrane Trafficking|trans-Golgi Network Vesicle Budding|Golgi Associated Vesicle Biogenesis|Vesicle-mediated transport"]
["SNED1-AS1",0.00936304801502018,0,0.00879036460408123,0.00897970798401625,0.00914917638776827,0.035169516939278,0.0174712784871715,0.00918137569296208,0.00941795707781111,0.0541068919995382,0.0088054053546441,0.00942000424351315,0.0089041756426921,0.00892651998492405,0,0,0,0.043316492828109,0.00865352866148771,0,0,0,0.00924338964560947,0,0,0.00889657971301822,0.00906044959879951,0.00880234847428379,105373970,null,"non_coding"]
["SNPH",5.87820008523488,6.31402084580623,5.8886309802324,6.69485519971151,6.37654125289859,6.21597800241055,5.6681391350604,5.76874495258048,5.83245263762521,7.0802138826567,6.26048230085849,5.78652204283556,5.4518132069665,6.43604421191475,5.78082081891282,5.90703153501759,5.39895081901331,5.95109358476382,5.77528611379666,6.10823856635211,5.86695749653248,5.07909082530658,4.97869782438877,5.60992564068808,6.04173303350136,5.65221106789285,4.93917811028521,6.22743635494915,9751,"syntaphilin","protein_coding",null,null,"GO:0005515,GO:0005737,GO:0005739,GO:0005881,GO:0007269,GO:0016020,GO:0016081,GO:0017075,GO:0030182,GO:0043005,GO:0098793","protein binding|cytoplasm|mitochondrion|cytoplasmic microtubule|neurotransmitter secretion|membrane|synaptic vesicle docking|syntaxin-1 binding|neuron differentiation|neuron projection|presynapse"]
["SNTB1",14.0388220480591,16.4236488983162,17.6325691188602,12.9162380958351,15.8790483713089,16.8689453057604,18.4028467843924,14.4036168891846,13.0089596652179,9.50873930966845,9.52132041503719,10.7763749789463,13.4056137843284,12.5000051503818,15.8192834292505,15.387819431554,10.3838372934458,9.65373219512375,9.967340893429,12.3813255978413,11.4551368125642,11.0232163331409,13.5334868495102,11.5960093008617,10.8219696536319,9.93360025711314,10.6388806688553,9.27168955803761,6641,"syntrophin beta 1","protein_coding",null,null,"GO:0003779,GO:0005198,GO:0005515,GO:0005516,GO:0005622,GO:0005737,GO:0005856,GO:0005925,GO:0006936,GO:0016010,GO:0030165,GO:0032991,GO:0042383,GO:0045202","actin binding|structural molecule activity|protein binding|calmodulin binding|intracellular anatomical structure|cytoplasm|cytoskeleton|focal adhesion|muscle contraction|dystrophin-associated glycoprotein complex|PDZ domain binding|protein-containing complex|sarcolemma|synapse","WP4754,WP5356,WP5406","IL-18 signaling pathway|Disturbed pathways in Duchenne Muscular Dystrophy|13q12.12 copy number variation"]
["SNX6",32.0604898478502,27.8025880302357,29.9817578063832,25.4465178312291,32.8374904665996,29.7677456196377,31.060645216165,28.0862154755666,29.0780739675439,18.2370364112376,23.3524907809006,25.155989813918,35.224058986087,25.721876386541,30.4723361458618,28.7998734899497,35.8975129883105,28.9389727397981,37.1818542068839,36.3114468477861,39.5552854133665,34.8196850369068,51.9617417787437,43.6243696473114,36.1075355676485,33.4954000756348,46.5479016908028,31.5558278485163,58533,"sorting nexin 6","protein_coding","hsa04144","Endocytosis","GO:0005515,GO:0005634,GO:0005737,GO:0005764,GO:0005768,GO:0005829,GO:0006886,GO:0007175,GO:0016241,GO:0030512,GO:0030904,GO:0030905,GO:0031901,GO:0034452,GO:0034713,GO:0035091,GO:0042147,GO:0042803,GO:0043524,GO:0045892,GO:0071364,GO:0097422,GO:0098978,GO:0099072,GO:1903593,GO:1904646","protein binding|nucleus|cytoplasm|lysosome|endosome|cytosol|intracellular protein transport|negative regulation of epidermal growth factor-activated receptor activity|regulation of macroautophagy|negative regulation of transforming growth factor beta receptor signaling pathway|retromer complex|retromer, tubulation complex|early endosome membrane|dynactin binding|type I transforming growth factor beta receptor binding|phosphatidylinositol binding|retrograde transport, endosome to Golgi|protein homodimerization activity|negative regulation of neuron apoptotic process|negative regulation of DNA-templated transcription|cellular response to epidermal growth factor stimulus|tubular endosome|glutamatergic synapse|regulation of postsynaptic membrane neurotransmitter receptor levels|regulation of histamine secretion by mast cell|cellular response to amyloid-beta"]
["SON",25.9137235857904,25.5344474781348,21.4256428974445,18.7428181072874,27.7085597380993,22.5608418416095,19.4315616456671,18.8674388713413,25.521127599312,22.3268421215283,19.1178609766774,22.4992458738755,25.6470951090683,20.4347246355449,23.532898749805,24.5892466052186,21.0287760529265,19.5712047820244,16.9193097197007,22.4299311483767,21.4521755806461,19.442748490523,22.3086001325412,22.2467803962775,21.9392298618139,16.8107160704618,18.6993511393553,17.4186035434295,6651,"SON DNA and RNA binding protein","protein_coding",null,null,"GO:0000226,GO:0000281,GO:0003677,GO:0003723,GO:0005515,GO:0006397,GO:0008380,GO:0016607,GO:0043066,GO:0043484,GO:0048024,GO:0051726","microtubule cytoskeleton organization|mitotic cytokinesis|DNA binding|RNA binding|protein binding|mRNA processing|RNA splicing|nuclear speck|negative regulation of apoptotic process|regulation of RNA splicing|regulation of mRNA splicing, via spliceosome|regulation of cell cycle"]
["SOS1",5.28691922291747,5.27540896677123,4.6785737776865,3.80143425600162,5.74785128736068,4.4914639426112,4.53121723734592,3.99662061851014,5.45428108731972,3.90555499223312,3.84127650095159,4.35251363011535,6.13202648142336,4.38017318968554,5.89249241960078,5.71694200116569,3.94970752379604,3.45752653015187,3.45362735681912,4.53990516308624,3.9748087304082,3.79847162968548,5.30663333031927,4.65844687098693,4.27740526219639,3.50862643502849,4.53144415147761,3.35510168173037,6654,"SOS Ras/Rac guanine nucleotide exchange factor 1","protein_coding","hsa04010,hsa04012,hsa04014,hsa04630,hsa04068,hsa04072,hsa04151,hsa04150,hsa04510,hsa04540,hsa04810,hsa04650,hsa04660,hsa04662,hsa04664,hsa04062,hsa04910,hsa04912,hsa04915,hsa04917,hsa04926,hsa04935,hsa04722,hsa04714,hsa05200,hsa05206,hsa05205,hsa05207,hsa05208,hsa05231,hsa05210,hsa05225,hsa05226,hsa05214,hsa05221,hsa05220,hsa05211,hsa05215,hsa05213,hsa05224,hsa05223,hsa05161,hsa05160,hsa05163,hsa05165,hsa05034,hsa01521,hsa01522","MAPK signaling pathway|ErbB signaling pathway|Ras signaling pathway|JAK-STAT signaling pathway|FoxO signaling pathway|Phospholipase D signaling pathway|PI3K-Akt signaling pathway|mTOR signaling pathway|Focal adhesion|Gap junction|Regulation of actin cytoskeleton|Natural killer cell mediated cytotoxicity|T cell receptor signaling pathway|B cell receptor signaling pathway|Fc epsilon RI signaling pathway|Chemokine signaling pathway|Insulin signaling pathway|GnRH signaling pathway|Estrogen signaling pathway|Prolactin signaling pathway|Relaxin signaling pathway|Growth hormone synthesis, secretion and action|Neurotrophin signaling pathway|Thermogenesis|Pathways in cancer|MicroRNAs in cancer|Proteoglycans in cancer|Chemical carcinogenesis - receptor activation|Chemical carcinogenesis - reactive oxygen species|Choline metabolism in cancer|Colorectal cancer|Hepatocellular carcinoma|Gastric cancer|Glioma|Acute myeloid leukemia|Chronic myeloid leukemia|Renal cell carcinoma|Prostate cancer|Endometrial cancer|Breast cancer|Non-small cell lung cancer|Hepatitis B|Hepatitis C|Human cytomegalovirus infection|Human papillomavirus infection|Alcoholism|EGFR tyrosine kinase inhibitor resistance|Endocrine resistance","GO:0001782,GO:0001942,GO:0002931,GO:0003209,GO:0003344,GO:0005085,GO:0005096,GO:0005154,GO:0005515,GO:0005737,GO:0005829,GO:0005886,GO:0006357,GO:0007165,GO:0007173,GO:0007265,GO:0007296,GO:0007411,GO:0008286,GO:0008543,GO:0017124,GO:0019221,GO:0033081,GO:0035264,GO:0038095,GO:0042127,GO:0042129,GO:0043025,GO:0043547,GO:0045742,GO:0046982,GO:0048009,GO:0048011,GO:0048514,GO:0050853,GO:0050900,GO:0051057,GO:0060021,GO:0061029,GO:0061384,GO:0140693,GO:1904693,GO:1905360,GO:2000973","B cell homeostasis|hair follicle development|response to ischemia|cardiac atrium morphogenesis|pericardium morphogenesis|guanyl-nucleotide exchange factor activity|GTPase activator activity|epidermal growth factor receptor binding|protein binding|cytoplasm|cytosol|plasma membrane|regulation of transcription by RNA polymerase II|signal transduction|epidermal growth factor receptor signaling pathway|Ras protein signal transduction|vitellogenesis|axon guidance|insulin receptor signaling pathway|fibroblast growth factor receptor signaling pathway|SH3 domain binding|cytokine-mediated signaling pathway|regulation of T cell differentiation in thymus|multicellular organism growth|Fc-epsilon receptor signaling pathway|regulation of cell population proliferation|regulation of T cell proliferation|neuronal cell body|positive regulation of GTPase activity|positive regulation of epidermal growth factor receptor signaling pathway|protein heterodimerization activity|insulin-like growth factor receptor signaling pathway|neurotrophin TRK receptor signaling pathway|blood vessel morphogenesis|B cell receptor signaling pathway|leukocyte migration|positive regulation of small GTPase mediated signal transduction|roof of mouth development|eyelid development in camera-type eye|heart trabecula morphogenesis|molecular condensate scaffold activity|midbrain morphogenesis|GTPase complex|regulation of pro-B cell differentiation","WP4205,WP306,WP185,WP4321,WP4666,WP2374,WP3972,WP4262,WP4549,WP4806,WP364,WP4223,WP4685,WP673,WP4746,WP286,WP3981,WP4239,WP69,WP244,WP2643,WP395,WP51,WP2253,WP127,WP3929,WP5380,WP5365,WP4298,WP3932,WP5366,WP382,WP3863,WP710,WP481,WP3676,WP2034,WP2263,WP313,WP49,WP4535,WP422,WP23,WP3303,WP437,WP4928,WP2037,WP4659,WP581,WP3680,WP3646,WP2526,WP231,WP4255,WP304,WP4155,WP5087,WP4172,WP5098,WP3915,WP3931","MET in type 1 papillary renal cell carcinoma|Focal adhesion|Integrin-mediated cell adhesion|Thermogenesis|Hepatitis B infection|Oncostatin M signaling pathway|PDGFR-beta pathway|Breast cancer pathway|Fragile X syndrome|EGFR tyrosine kinase inhibitor resistance|IL6 signaling pathway|Ras signaling|Melanoma|ErbB signaling pathway|Thyroid hormones production and peripheral downstream signaling effects|IL-3 signaling pathway|miRNA regulation of prostate cancer signaling pathways|Epithelial to mesenchymal transition in colorectal cancer|T-cell receptor signaling pathway|Alpha 6 beta 4 signaling pathway|Nanoparticle-mediated activation of receptor signaling|IL-4 signaling pathway|Regulation of actin cytoskeleton|Pilocytic astrocytoma|IL-5 signaling pathway|Chemokine signaling pathway|5q35 copy number variation|4p16.3 copy number variation|Acute viral myocarditis|Focal adhesion: PI3K-Akt-mTOR-signaling pathway|NF1 copy number variation syndrome |MAPK signaling pathway|T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection|DNA damage response (only ATM dependent)|Insulin signaling|BDNF-TrkB signaling|Leptin signaling pathway|Androgen receptor network in prostate cancer|Hepatocyte growth factor receptor signaling|IL-2 signaling pathway|Envelope proteins and their potential roles in EDMD physiopathology|MAPK cascade|B cell receptor signaling pathway|RAC1/PAK1/p38/MMP2 pathway|EGF/EGFR signaling pathway|MAPK pathway in congenital thyroid cancer|Prolactin signaling pathway|Gastrin signaling pathway|EPO receptor signaling|Physico-chemical features and toxicity-associated pathways|Hepatitis C and hepatocellular carcinoma|PDGF pathway|TNF-alpha signaling pathway|Non-small cell lung cancer|Kit receptor signaling pathway|Endometrial cancer|Pleural mesothelioma|PI3K-Akt signaling pathway|T-cell activation SARS-CoV-2|Angiopoietin-like protein 8 regulatory pathway|Embryonic stem cell pluripotency pathways","R-HSA-109582,R-HSA-112399,R-HSA-112399,R-HSA-112412,R-HSA-112412,R-HSA-1226099,R-HSA-1227986,R-HSA-1227986,R-HSA-1227990,R-HSA-1236382,R-HSA-1236394,R-HSA-1250196,R-HSA-1250347,R-HSA-1266738,R-HSA-1266738,R-HSA-1280215,R-HSA-1280215,R-HSA-1280218,R-HSA-1280218,R-HSA-1433557,R-HSA-1433559,R-HSA-162582,R-HSA-162582,R-HSA-1643685,R-HSA-1643713,R-HSA-166520,R-HSA-166520,R-HSA-167044,R-HSA-167044,R-HSA-168249,R-HSA-168249,R-HSA-168256,R-HSA-168256,R-HSA-177929,R-HSA-179812,R-HSA-180336,R-HSA-186763,R-HSA-186797,R-HSA-187037,R-HSA-187037,R-HSA-187687,R-HSA-187687,R-HSA-190236,R-HSA-193648,R-HSA-193704,R-HSA-194315,R-HSA-1963640,R-HSA-1963640,R-HSA-202733,R-HSA-204998,R-HSA-210993,R-HSA-2172127,R-HSA-2179392,R-HSA-2404192,R-HSA-2404192,R-HSA-2424491,R-HSA-2428924,R-HSA-2428924,R-HSA-2428928,R-HSA-2428928,R-HSA-2428933,R-HSA-2428933,R-HSA-2454202,R-HSA-2454202,R-HSA-2730905,R-HSA-2730905,R-HSA-2871796,R-HSA-2871809,R-HSA-2871809,R-HSA-354192,R-HSA-354194,R-HSA-372790,R-HSA-375165,R-HSA-376176,R-HSA-388396,R-HSA-416476,R-HSA-416482,R-HSA-422475,R-HSA-422475,R-HSA-428540,R-HSA-449147,R-HSA-451927,R-HSA-512988,R-HSA-5637810,R-HSA-5637812,R-HSA-5637815,R-HSA-5654687,R-HSA-5654688,R-HSA-5654693,R-HSA-5654696,R-HSA-5654699,R-HSA-5654700,R-HSA-5654704,R-HSA-5654706,R-HSA-5654708,R-HSA-5654712,R-HSA-5654716,R-HSA-5654719,R-HSA-5654736,R-HSA-5654738,R-HSA-5654741,R-HSA-5654743,R-HSA-5655253,R-HSA-5655291,R-HSA-5655302,R-HSA-5655332,R-HSA-5663202,R-HSA-5663205,R-HSA-5673001,R-HSA-5683057,R-HSA-5684996,R-HSA-6806834,R-HSA-73887,R-HSA-74749,R-HSA-74751,R-HSA-74751,R-HSA-74752,R-HSA-74752,R-HSA-76002,R-HSA-76009,R-HSA-881907,R-HSA-8851805,R-HSA-8853659,R-HSA-8983432,R-HSA-9006115,R-HSA-9006115,R-HSA-9006335,R-HSA-9006934,R-HSA-9006934,R-HSA-9012999,R-HSA-9013149,R-HSA-9026519,R-HSA-9027284,R-HSA-9028731,R-HSA-9028731,R-HSA-9034015,R-HSA-9034864,R-HSA-912526,R-HSA-9607240,R-HSA-9634285,R-HSA-9664565,R-HSA-9665348,R-HSA-9665686,R-HSA-9669938,R-HSA-9670439,R-HSA-9671555,R-HSA-9673767,R-HSA-9673770,R-HSA-9675108,R-HSA-9675108,R-HSA-9679191,R-HSA-9679506,R-HSA-9680350,R-HSA-9682385,R-HSA-9703465,R-HSA-9703648,R-HSA-9716542,R-HSA-9824446,R-HSA-983695,R-HSA-983695,R-HSA-983705,R-HSA-983705","Hemostasis|IRS-mediated signalling|IRS-mediated signalling|SOS-mediated signalling|SOS-mediated signalling|Signaling by FGFR in disease|Signaling by ERBB2|Signaling by ERBB2|Signaling by ERBB2 in Cancer|Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants|Signaling by ERBB4|SHC1 events in ERBB2 signaling|SHC1 events in ERBB4 signaling|Developmental Biology|Developmental Biology|Cytokine Signaling in Immune system|Cytokine Signaling in Immune system|Adaptive Immune System|Adaptive Immune System|Signaling by SCF-KIT|Regulation of KIT signaling|Signal Transduction|Signal Transduction|Disease|Signaling by EGFR in Cancer|Signaling by NTRKs|Signaling by NTRKs|Signalling to RAS|Signalling to RAS|Innate Immune System|Innate Immune System|Immune System|Immune System|Signaling by EGFR|GRB2 events in EGFR signaling|SHC1 events in EGFR signaling|Downstream signal transduction|Signaling by PDGF|Signaling by NTRK1 (TRKA)|Signaling by NTRK1 (TRKA)|Signalling to ERKs|Signalling to ERKs|Signaling by FGFR|NRAGE signals death through JNK|p75 NTR receptor-mediated signalling|Signaling by Rho GTPases|GRB2 events in ERBB2 signaling|GRB2 events in ERBB2 signaling|Cell surface interactions at the vascular wall|Cell death signalling via NRAGE, NRIF and NADE|Tie2 Signaling|DAP12 interactions|EGFR Transactivation by Gastrin|Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)|Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)|DAP12 signaling|IGF1R signaling cascade|IGF1R signaling cascade|IRS-related events triggered by IGF1R|IRS-related events triggered by IGF1R|SHC-related events triggered by IGF1R|SHC-related events triggered by IGF1R|Fc epsilon receptor (FCERI) signaling|Fc epsilon receptor (FCERI) signaling|Role of LAT2/NTAL/LAB on calcium mobilization|Role of LAT2/NTAL/LAB on calcium mobilization|FCERI mediated MAPK activation|FCERI mediated Ca+2 mobilization|FCERI mediated Ca+2 mobilization|Integrin signaling|GRB2:SOS provides linkage to MAPK signaling for Integrins |Signaling by GPCR|NCAM signaling for neurite out-growth|Signaling by ROBO receptors|GPCR downstream signalling|G alpha (q) signalling events|G alpha (12/13) signalling events|Axon guidance|Axon guidance|Activation of RAC1|Signaling by Interleukins|Interleukin-2 family signaling|Interleukin-3, Interleukin-5 and GM-CSF signaling|Constitutive Signaling by EGFRvIII|Signaling by EGFRvIII in Cancer|Signaling by Ligand-Responsive EGFR Variants in Cancer|Downstream signaling of activated FGFR1|SHC-mediated cascade:FGFR1|FRS-mediated FGFR1 signaling|Downstream signaling of activated FGFR2|SHC-mediated cascade:FGFR2|FRS-mediated FGFR2 signaling|SHC-mediated cascade:FGFR3|FRS-mediated FGFR3 signaling|Downstream signaling of activated FGFR3|FRS-mediated FGFR4 signaling|Downstream signaling of activated FGFR4|SHC-mediated cascade:FGFR4|Signaling by FGFR1|Signaling by FGFR2|Signaling by FGFR3|Signaling by FGFR4|Signaling by FGFR2 in disease|Signaling by FGFR4 in disease|Signaling by FGFR1 in disease|Signaling by FGFR3 in disease|Diseases of signal transduction by growth factor receptors and second messengers|Infectious disease|RAF/MAP kinase cascade|MAPK family signaling cascades|MAPK1/MAPK3 signaling|Signaling by MET|Death Receptor Signaling|Signal attenuation|Insulin receptor signalling cascade|Insulin receptor signalling cascade|Signaling by Insulin receptor|Signaling by Insulin receptor|Platelet activation, signaling and aggregation|Platelet Aggregation (Plug Formation)|Gastrin-CREB signalling pathway via PKC and MAPK|MET activates RAS signaling|RET signaling|Interleukin-15 signaling|Signaling by NTRK2 (TRKB)|Signaling by NTRK2 (TRKB)|Signaling by Erythropoietin|Signaling by Receptor Tyrosine Kinases|Signaling by Receptor Tyrosine Kinases|RHO GTPase cycle|RAC1 GTPase cycle|Activated NTRK2 signals through RAS|Erythropoietin activates RAS|Activated NTRK2 signals through FRS2 and FRS3|Activated NTRK2 signals through FRS2 and FRS3|Signaling by NTRK3 (TRKC)|Activated NTRK3 signals through RAS|Interleukin receptor SHC signaling|FLT3 Signaling|Constitutive Signaling by Overexpressed ERBB2|Signaling by ERBB2 KD Mutants|Signaling by ERBB2 ECD mutants|Signaling by ERBB2 TMD/JMD mutants|Signaling by KIT in disease|Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants|Signaling by PDGFR in disease|Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants|Signaling by PDGFRA extracellular domain mutants|Nervous system development|Nervous system development|Potential therapeutics for SARS|SARS-CoV Infections|Signaling by CSF1 (M-CSF) in myeloid cells|FLT3 signaling in disease|Signaling by FLT3 fusion proteins|Signaling by FLT3 ITD and TKD mutants|Signaling by Rho GTPases, Miro GTPases and RHOBTB3|Viral Infection Pathways|Antigen activates B Cell Receptor (BCR) leading to generation of second messengers|Antigen activates B Cell Receptor (BCR) leading to generation of second messengers|Signaling by the B Cell Receptor (BCR)|Signaling by the B Cell Receptor (BCR)"]
["SP5",0.126357258915202,0.128199165300362,0.0395429057736716,0.0888682412955658,0.222247790046997,0.150297480163706,0.0314373817278543,0.09086405838138,0.118625055618204,0.178490746118059,0.15052014947012,0.1186508409497,0.144197559423621,0.208808039672345,0.156682058610722,0.0559094085093838,0.0566929302011156,0.0155885228565157,0.0155709431352644,0.0648041706097844,0.0477050062854844,0.0480428926945977,0.0498969727307056,0.0822983883052331,0.0501094082137685,0.0320165662422243,0.0163031464968398,0.0633549031436576,389058,"Sp5 transcription factor","protein_coding",null,null,"GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001227,GO:0005634,GO:0006357,GO:0036342,GO:0046872,GO:0060349,GO:0071407","negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|post-anal tail morphogenesis|metal ion binding|bone morphogenesis|cellular response to organic cyclic compound"]
["SPAG7",28.5137539873938,27.3853365693108,31.0841624516514,34.1348701327507,25.6925150965424,29.3969779339829,29.0346161678764,30.4102552785446,29.9374118788015,33.4182799056072,36.7789087372011,34.4432647150486,27.6442816693137,34.1532178249504,29.4146363579488,28.863072219032,35.3316123358636,32.9463608930845,39.379877238202,31.8978880964865,39.5467588337638,34.9602743178079,35.3046772730759,40.0757369138526,33.9108062297905,37.1743837787291,41.05259131607,42.5362210122406,9552,"sperm associated antigen 7","protein_coding",null,null,"GO:0003676,GO:0005515,GO:0005634","nucleic acid binding|protein binding|nucleus"]
["SPART",17.7569502776281,17.9647823363049,16.6754938562512,13.882390158511,19.9554927423567,18.0974514070967,17.5754648195122,16.8703895352346,17.3050978243473,13.2568340847047,14.0445635042983,16.3257400237532,19.5290628507812,17.55486118959,18.6893985401057,19.1759590790567,15.3593149603817,12.8909264075998,12.9037563177336,13.3404997132262,14.971208612381,12.4830599253337,15.9416960600384,16.9382197358496,14.8695219393767,12.0422617517439,15.6739441384484,12.425077306387,23111,"spartin","protein_coding","hsa04144","Endocytosis","GO:0005515,GO:0005737,GO:0005741,GO:0005811,GO:0005829,GO:0005886,GO:0009838,GO:0030496,GO:0030509,GO:0030514,GO:0031625,GO:0034389,GO:0043231,GO:0045202,GO:0048669,GO:0048698,GO:0050905,GO:0051301,GO:0051881,GO:0060612","protein binding|cytoplasm|mitochondrial outer membrane|lipid droplet|cytosol|plasma membrane|abscission|midbody|BMP signaling pathway|negative regulation of BMP signaling pathway|ubiquitin protein ligase binding|lipid droplet organization|intracellular membrane-bounded organelle|synapse|collateral sprouting in absence of injury|negative regulation of collateral sprouting in absence of injury|neuromuscular process|cell division|regulation of mitochondrial membrane potential|adipose tissue development"]
["SPATC1",0,0,0,0.00442453864213294,0,0,0,0.00452390563409855,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,375686,"spermatogenesis and centriole associated 1","protein_coding",null,null,"GO:0005737,GO:0005813","cytoplasm|centrosome"]
["SPECC1",5.13451718766535,4.74659295815147,4.12989577689711,4.50735560279192,4.77563370495703,4.51393679990574,3.72356238825063,4.58635786956247,3.83409402201205,3.99465645978506,3.80174234315003,3.86602143887821,3.48777165650484,3.14490721620352,2.67304406343446,3.06124783557129,4.56212771655848,4.67453129027612,3.60096656348361,4.56497161461265,4.63619394061891,4.56131456437486,3.64505083475959,4.44057771707025,4.73504479561834,4.72209479637667,3.94575273772023,4.45513344738706,92521,"sperm antigen with calponin homology and coiled-coil domains 1","protein_coding",null,null,"GO:0001650,GO:0001824,GO:0005654,GO:0005815,GO:0005829,GO:0008306,GO:0016020,GO:0030036,GO:0031941,GO:0043231,GO:0045177","fibrillar center|blastocyst development|nucleoplasm|microtubule organizing center|cytosol|associative learning|membrane|actin cytoskeleton organization|filamentous actin|intracellular membrane-bounded organelle|apical part of cell"]
["SPINK1",0.222411016792434,0.0423099555446741,0,0.127983065772191,0.173864546669206,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,6690,"serine peptidase inhibitor Kazal type 1","protein_coding",null,null,"GO:0004866,GO:0004867,GO:0005515,GO:0007204,GO:0007263,GO:0010751,GO:0031667,GO:0045471,GO:0048240,GO:0050679,GO:0050732,GO:0060046,GO:0070062,GO:0071375,GO:0090187,GO:0090277,GO:0090281,GO:2001256","endopeptidase inhibitor activity|serine-type endopeptidase inhibitor activity|protein binding|positive regulation of cytosolic calcium ion concentration|nitric oxide mediated signal transduction|negative regulation of nitric oxide mediated signal transduction|response to nutrient levels|response to ethanol|sperm capacitation|positive regulation of epithelial cell proliferation|negative regulation of peptidyl-tyrosine phosphorylation|regulation of acrosome reaction|extracellular exosome|cellular response to peptide hormone stimulus|positive regulation of pancreatic juice secretion|positive regulation of peptide hormone secretion|negative regulation of calcium ion import|regulation of store-operated calcium entry","WP2263","Androgen receptor network in prostate cancer"]
["SPP1",1.00123085159474,0.351631996252423,0.144614055400856,0.29545804898266,0.526809576407697,0.274829678013635,0.344912988099887,0.226570119600324,0.402841005201413,0.534081401371441,0.333181443639124,0.464917580864131,0.307621460103726,0.117483204738726,0.28650433574532,0.116839253701243,0.0740479088341102,0.114018910036229,0.05694516346611,0.23699810965864,0.0436160057467286,0.117133147903019,0.22810044676894,0.0300976962944852,0.0458143160811597,0.146361445678739,0.163963073339646,0.0434433621556509,6696,"secreted phosphoprotein 1","protein_coding","hsa04371,hsa04151,hsa04512,hsa04510,hsa04620,hsa04929,hsa05165","Apelin signaling pathway|PI3K-Akt signaling pathway|ECM-receptor interaction|Focal adhesion|Toll-like receptor signaling pathway|GnRH secretion|Human papillomavirus infection","GO:0001649,GO:0005125,GO:0005178,GO:0005515,GO:0005576,GO:0005615,GO:0005788,GO:0005794,GO:0006710,GO:0007155,GO:0007165,GO:0007566,GO:0031214,GO:0033280,GO:0036005,GO:0036094,GO:0042995,GO:0043167,GO:0045780,GO:0045893,GO:0046697,GO:0048471,GO:0048545,GO:0048685,GO:0050840,GO:0070062,GO:0071394,GO:2000866","osteoblast differentiation|cytokine activity|integrin binding|protein binding|extracellular region|extracellular space|endoplasmic reticulum lumen|Golgi apparatus|androgen catabolic process|cell adhesion|signal transduction|embryo implantation|biomineral tissue development|response to vitamin D|response to macrophage colony-stimulating factor|small molecule binding|cell projection|ion binding|positive regulation of bone resorption|positive regulation of DNA-templated transcription|decidualization|perinuclear region of cytoplasm|response to steroid hormone|negative regulation of collateral sprouting of intact axon in response to injury|extracellular matrix binding|extracellular exosome|cellular response to testosterone stimulus|positive regulation of estradiol secretion","WP306,WP5373,WP2806,WP4816,WP5095,WP12,WP4844,WP4808,WP4300,WP3945,WP4754,WP3624,WP3932,WP75,WP2380,WP560,WP4879,WP5356,WP4790,WP474,WP1434,WP2877,WP4172,WP5094","Focal adhesion|Role of hypoxia, angiogenesis, and FGF pathway in OA chondrocyte hypertrophy|Complement system|TGF-beta receptor signaling in skeletal dysplasias|Overview of proinflammatory and profibrotic mediators|Osteoclast signaling|Influence of laminopathies on Wnt signaling|Endochondral ossification with skeletal dysplasias|Extracellular vesicles in the crosstalk of cardiac cells|TYROBP causal network in microglia|IL-18 signaling pathway|Lung fibrosis|Focal adhesion: PI3K-Akt-mTOR-signaling pathway|Toll-like receptor signaling pathway|Brain-derived neurotrophic factor (BDNF) signaling pathway|TGF-beta receptor signaling|Overlap between signal transduction pathways contributing to LMNA laminopathies|Disturbed pathways in Duchenne Muscular Dystrophy|FGF23 signaling in hypophosphatemic rickets and related disorders|Endochondral ossification|Osteopontin signaling|Vitamin D receptor pathway|PI3K-Akt signaling pathway|Orexin receptor pathway","R-HSA-1474228,R-HSA-1474244,R-HSA-1474244,R-HSA-162582,R-HSA-186797,R-HSA-212436,R-HSA-216083,R-HSA-216083,R-HSA-381426,R-HSA-392499,R-HSA-597592,R-HSA-73857,R-HSA-74160,R-HSA-8878159,R-HSA-8949275,R-HSA-8957275,R-HSA-9006934","Degradation of the extracellular matrix|Extracellular matrix organization|Extracellular matrix organization|Signal Transduction|Signaling by PDGF|Generic Transcription Pathway|Integrin cell surface interactions|Integrin cell surface interactions|Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)|Metabolism of proteins|Post-translational protein modification|RNA Polymerase II Transcription|Gene expression (Transcription)|Transcriptional regulation by RUNX3|RUNX3 Regulates Immune Response and Cell Migration|Post-translational protein phosphorylation|Signaling by Receptor Tyrosine Kinases"]
["SPRING1",6.77584427584202,6.85879227597952,6.01600305831773,5.95535917328418,6.1646598900782,5.99334836636666,6.00541296334611,5.3926700078145,6.43908273824631,6.53833136849186,6.429453884196,6.25058311008288,6.099978514004,5.9505849718015,6.65257219185519,6.82492525291722,4.81056554661665,5.10021834925737,4.78696547562177,5.46674631728397,4.97922654417367,5.75952140286846,4.74374574200616,5.31960529391907,5.36339959107413,4.73294978771832,5.16066370002033,4.88132009504658,79794,"SREBF pathway regulator in golgi 1","protein_coding",null,null,"GO:0000139,GO:0005515,GO:2000640","Golgi membrane|protein binding|positive regulation of SREBP signaling pathway"]
["SQLE-DT",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.0619607854705698,105375744,"SQLE divergent transcript","non_coding"]
["SRGAP2",6.48164474034649,7.66626191996533,7.17599331994596,6.63447009645498,7.20225991540475,7.01649113693096,6.49876494745709,6.61519172686816,6.69792782057525,7.18284613891921,7.08509086609293,6.97392544592686,6.39139069946952,6.9626147872056,6.98283305250706,7.2578704382161,5.30939425636354,5.739543794384,4.33685379246439,5.90555226220661,5.49107092456031,5.26523095891813,4.64080380897567,4.83999037547119,5.45545133047414,4.76071838675863,4.46184213873021,5.18899269329393,23380,"SLIT-ROBO Rho GTPase activating protein 2","protein_coding","hsa04360","Axon guidance","GO:0003363,GO:0005096,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0007165,GO:0014069,GO:0021816,GO:0030027,GO:0030336,GO:0031267,GO:0034446,GO:0042802,GO:0042803,GO:0043547,GO:0044327,GO:0045211,GO:0045335,GO:0046847,GO:0048812,GO:0051014,GO:0051056,GO:0060996,GO:1904861,GO:1904862,GO:2001223","lamellipodium assembly involved in ameboidal cell migration|GTPase activator activity|protein binding|nucleus|cytoplasm|cytosol|plasma membrane|signal transduction|postsynaptic density|extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration|lamellipodium|negative regulation of cell migration|small GTPase binding|substrate adhesion-dependent cell spreading|identical protein binding|protein homodimerization activity|positive regulation of GTPase activity|dendritic spine head|postsynaptic membrane|phagocytic vesicle|filopodium assembly|neuron projection morphogenesis|actin filament severing|regulation of small GTPase mediated signal transduction|dendritic spine development|excitatory synapse assembly|inhibitory synapse assembly|negative regulation of neuron migration",null,null,"R-HSA-1266738,R-HSA-162582,R-HSA-194315,R-HSA-195258,R-HSA-376176,R-HSA-422475,R-HSA-428543,R-HSA-5663220,R-HSA-9012999,R-HSA-9013148,R-HSA-9013149,R-HSA-9013406,R-HSA-9013420,R-HSA-9013423,R-HSA-9035034,R-HSA-9675108,R-HSA-9716542","Developmental Biology|Signal Transduction|Signaling by Rho GTPases|RHO GTPase Effectors|Signaling by ROBO receptors|Axon guidance|Inactivation of CDC42 and RAC1|RHO GTPases Activate Formins|RHO GTPase cycle|CDC42 GTPase cycle|RAC1 GTPase cycle|RHOQ GTPase cycle|RHOU GTPase cycle|RAC3 GTPase cycle|RHOF GTPase cycle|Nervous system development|Signaling by Rho GTPases, Miro GTPases and RHOBTB3"]
["SRP19",3.95181436674129,3.515203175094,3.57533600997575,3.62535386666752,3.42423474275651,3.24312099775657,3.84982367029629,3.6929722950413,3.75132561509858,2.92235031756414,3.66086497526951,3.81160893016415,3.68854523009063,3.22014631345051,3.790341374014,3.65351417529958,4.21888289185885,3.72158281916441,4.59925696366671,4.26298710286772,4.46050359838938,3.98911018802799,5.4018149031216,4.65002650931687,4.15790711014667,4.16145156712131,5.12331102609264,4.22586531566967,6728,"signal recognition particle 19","protein_coding","hsa03060","Protein export","GO:0003723,GO:0005515,GO:0005730,GO:0005786,GO:0005829,GO:0006613,GO:0006617,GO:0008312,GO:0016604,GO:0043022,GO:0048500","RNA binding|protein binding|nucleolus|signal recognition particle, endoplasmic reticulum targeting|cytosol|cotranslational protein targeting to membrane|SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition|7S RNA binding|nuclear body|ribosome binding|signal recognition particle",null,null,"R-HSA-1799339,R-HSA-1799339,R-HSA-392499,R-HSA-392499,R-HSA-72766,R-HSA-72766","SRP-dependent cotranslational protein targeting to membrane|SRP-dependent cotranslational protein targeting to membrane|Metabolism of proteins|Metabolism of proteins|Translation|Translation"]
["SRSF2",56.4051753150547,56.2380273565343,57.6101301531508,57.9785316757865,51.4274957731779,53.1809120354733,53.6355896424735,51.1356703726145,58.9138890560726,56.9102517000238,59.094739535826,59.1189070300652,52.5593534179924,52.5698186745901,52.7441621804517,52.3938089443706,66.8605384052577,73.2171295611064,67.9719226759246,68.7540974447918,70.2743204302674,69.2587292322705,64.8273325089856,67.0519383192363,68.0978345395796,71.0221014501829,65.5075062209844,70.2783988027586,6427,"serine and arginine rich splicing factor 2","protein_coding","hsa03040,hsa05168","Spliceosome|Herpes simplex virus 1 infection","GO:0000398,GO:0003714,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006397,GO:0008380,GO:0016605,GO:0016607,GO:0045892","mRNA splicing, via spliceosome|transcription corepressor activity|RNA binding|protein binding|nucleus|nucleoplasm|cytosol|mRNA processing|RNA splicing|PML body|nuclear speck|negative regulation of DNA-templated transcription","WP411","mRNA processing","R-HSA-159236,R-HSA-72163,R-HSA-72165,R-HSA-72172,R-HSA-72187,R-HSA-72202,R-HSA-72203,R-HSA-73856,R-HSA-73857,R-HSA-74160,R-HSA-8953854","Transport of Mature mRNA derived from an Intron-Containing Transcript|mRNA Splicing - Major Pathway|mRNA Splicing - Minor Pathway|mRNA Splicing|mRNA 3'-end processing|Transport of Mature Transcript to Cytoplasm|Processing of Capped Intron-Containing Pre-mRNA|RNA Polymerase II Transcription Termination|RNA Polymerase II Transcription|Gene expression (Transcription)|Metabolism of RNA"]
["SSTR2",0,0.00667269565649252,0.00329309820366296,0,0.00342751838911969,0.00988155880951674,0.0065451933330601,0.00343958108263342,0.00352821059557816,0,0.00329873285829803,0.00352897751686068,0.0033357347658179,0.0100323166050473,0.0065241716012272,0.0133031030564199,0.00337238361638758,0.0162274798766592,0,0.00337302124188858,3.3106922601073502E-3,0.00666828265550695,0,0,0.00347755598100323,0,6.7885580728546E-3,0,6752,"somatostatin receptor 2","protein_coding","hsa04024,hsa04080,hsa04935,hsa04971","cAMP signaling pathway|Neuroactive ligand-receptor interaction|Growth hormone synthesis, secretion and action|Gastric acid secretion","GO:0004994,GO:0005515,GO:0005829,GO:0005886,GO:0007187,GO:0007193,GO:0007218,GO:0007283,GO:0008285,GO:0021549,GO:0030165,GO:0030432,GO:0030900,GO:0038170,GO:0042594,GO:0042923,GO:0043005,GO:0071385,GO:0071392","somatostatin receptor activity|protein binding|cytosol|plasma membrane|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway|neuropeptide signaling pathway|spermatogenesis|negative regulation of cell population proliferation|cerebellum development|PDZ domain binding|peristalsis|forebrain development|somatostatin signaling pathway|response to starvation|neuropeptide binding|neuron projection|cellular response to glucocorticoid stimulus|cellular response to estradiol stimulus","WP24,WP455,WP706,WP117","Peptide GPCRs|GPCRs, class A rhodopsin-like|Sudden infant death syndrome (SIDS) susceptibility pathways|GPCRs, other","R-HSA-162582,R-HSA-372790,R-HSA-373076,R-HSA-375276,R-HSA-388396,R-HSA-418594,R-HSA-500792","Signal Transduction|Signaling by GPCR|Class A/1 (Rhodopsin-like receptors)|Peptide ligand-binding receptors|GPCR downstream signalling|G alpha (i) signalling events|GPCR ligand binding"]
["ST8SIA1",0.130518400747545,0.219234175748019,0.138178156365812,0.151807666560319,0.225225068722771,0.22426499889419,0.26427221067198,0.215125298133613,0.265360909711211,0.179197842080747,0.224597252846167,0.19836547310315,0.319547720481361,0.172088628554523,0.263423426035539,0.194842424980825,0.0827670558205518,0.0590973154548037,0.0461979151432591,0.0534081966496626,0.112705759844831,0.0369548022512616,0.0191904843440782,0.0651129723070145,0.066076071405814,0.0131931868722465,0.0483703120540834,0.0939848156246698,6489,"ST8 alpha-N-acetyl-neuraminide alpha-2%2C8-sialyltransferase 1","protein_coding","hsa00601,hsa00603,hsa00604","Glycosphingolipid biosynthesis - lacto and neolacto series|Glycosphingolipid biosynthesis - globo and isoglobo series|Glycosphingolipid biosynthesis - ganglio series","GO:0000139,GO:0003828,GO:0005515,GO:0005975,GO:0006486,GO:0006491,GO:0006688,GO:0008373,GO:0009311,GO:0016020,GO:0034605,GO:0050673,GO:0050679","Golgi membrane|alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity|protein binding|carbohydrate metabolic process|protein glycosylation|N-glycan processing|glycosphingolipid biosynthetic process|sialyltransferase activity|oligosaccharide metabolic process|membrane|cellular response to heat|epithelial cell proliferation|positive regulation of epithelial cell proliferation","WP5299,WP1423","Ganglio series sphingolipid metabolism|Ganglio sphingolipid metabolism","R-HSA-392499,R-HSA-4085001,R-HSA-446193,R-HSA-446203,R-HSA-446219,R-HSA-597592","Metabolism of proteins|Sialic acid metabolism|Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein|Asparagine N-linked glycosylation|Synthesis of substrates in N-glycan biosythesis|Post-translational protein modification"]
["STARD10",4.18804717388755,3.97252349128162,4.56185968753774,4.80436344670838,4.32978686189158,4.88882700329202,4.19884686425247,5.57025394181913,3.11872617100466,4.25647850282318,3.32932754373486,2.65382138433173,2.65152975268233,3.15452489118736,3.59360052023904,3.0275407477307,3.12558447804066,3.37193799128066,3.68891013333303,3.19292651759796,3.53795068074322,3.65098492122608,2.47843046238927,2.95002634817728,3.15424028813421,4.00138372950031,2.94436225144644,4.74210090482999,10809,"StAR related lipid transfer domain containing 10","protein_coding",null,null,"GO:0005515,GO:0005829,GO:0005902,GO:0006869,GO:0008289,GO:0016020,GO:0031514,GO:0046581","protein binding|cytosol|microvillus|lipid transport|lipid binding|membrane|motile cilium|intercellular canaliculus",null,null,"R-HSA-1430728,R-HSA-1483191,R-HSA-1483206,R-HSA-1483257,R-HSA-556833","Metabolism|Synthesis of PC|Glycerophospholipid biosynthesis|Phospholipid metabolism|Metabolism of lipids"]
["STARD7",54.1918108475171,52.3577994617294,49.4008807552348,52.2946310638283,51.8385615162208,49.8994286651083,48.4603003620131,52.4984727327787,42.032381482215,34.9495326934697,38.0824446867845,43.7119355160011,39.4205468936594,39.8999768388731,39.9977699399263,37.8951269893291,44.7116052424146,47.394279500272,40.7675602086924,45.9712381145393,42.4697456016228,45.1226663278685,41.4187722708658,43.5623378926177,42.5447720552315,44.7871658064162,40.846213171591,43.9600855926024,56910,"StAR related lipid transfer domain containing 7","protein_coding",null,null,"GO:0005515,GO:0005741,GO:0008289","protein binding|mitochondrial outer membrane|lipid binding","WP5221","2q11.2 copy number variation syndrome","R-HSA-1430728,R-HSA-1430728,R-HSA-1483191,R-HSA-1483191,R-HSA-1483206,R-HSA-1483206,R-HSA-1483257,R-HSA-1483257,R-HSA-556833,R-HSA-556833","Metabolism|Metabolism|Synthesis of PC|Synthesis of PC|Glycerophospholipid biosynthesis|Glycerophospholipid biosynthesis|Phospholipid metabolism|Phospholipid metabolism|Metabolism of lipids|Metabolism of lipids"]
["STIMATE",4.7843872740461,4.51831796758445,4.80116225245254,4.7410927442675,4.93051121258468,4.71688905528417,4.04497845840689,4.24580177750185,4.65241123937454,4.89802905950218,5.00709612331599,5.15077849653962,4.48506555449152,5.13013915085513,4.56570990352997,4.90268000419554,4.16285355945556,4.92103116144983,4.0437187906083,4.32209940576218,4.10815456039135,4.27227972135208,3.93229655809158,4.57429153210874,4.48421460799996,4.13029901775743,3.8544707231989,4.35898827700039,375346,"STIM activating enhancer","protein_coding",null,null,"GO:0005246,GO:0005515,GO:0005789,GO:0016020,GO:0032237,GO:0032541,GO:0035584,GO:0070886,GO:0140268","calcium channel regulator activity|protein binding|endoplasmic reticulum membrane|membrane|activation of store-operated calcium channel activity|cortical endoplasmic reticulum|calcium-mediated signaling using intracellular calcium source|positive regulation of calcineurin-NFAT signaling cascade|endoplasmic reticulum-plasma membrane contact site"]
["STK4",7.43963260247828,7.61736575890566,7.58197975845394,6.02548789986842,7.5397579456061,7.03749664918333,7.45082437708326,6.8414920274323,7.07596557662647,5.51868904198206,5.29198668217115,6.22393538601193,7.42953991329041,6.58418219809794,7.60322664960756,7.4469701967128,5.91685871436127,5.3255211132131,5.12348629629588,6.14048102058377,5.99364758671862,5.53512774201946,6.14214205732927,6.34211709591114,6.16191991641572,5.02615813397246,5.60386647349651,5.00917641450569,6789,"serine/threonine kinase 4","protein_coding","hsa04010,hsa04014,hsa04068,hsa05200,hsa05223","MAPK signaling pathway|Ras signaling pathway|FoxO signaling pathway|Pathways in cancer|Non-small cell lung cancer","GO:0000287,GO:0000902,GO:0001569,GO:0001841,GO:0001934,GO:0003157,GO:0004672,GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006468,GO:0006606,GO:0006915,GO:0007165,GO:0007417,GO:0008625,GO:0016604,GO:0018105,GO:0030216,GO:0032092,GO:0032991,GO:0033138,GO:0035265,GO:0035329,GO:0035556,GO:0042802,GO:0042803,GO:0043065,GO:0043408,GO:0043539,GO:0045600,GO:0046621,GO:0046777,GO:0050673,GO:0050680,GO:0050821,GO:0051262,GO:0060070,GO:0060215,GO:0060706,GO:0060800,GO:0061629,GO:0090090,GO:0097284,GO:0106310,GO:1902043,GO:1903945,GO:1904237","magnesium ion binding|cell morphogenesis|branching involved in blood vessel morphogenesis|neural tube formation|positive regulation of protein phosphorylation|endocardium development|protein kinase activity|protein serine/threonine kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytoplasm|cytosol|protein phosphorylation|protein import into nucleus|apoptotic process|signal transduction|central nervous system development|extrinsic apoptotic signaling pathway via death domain receptors|nuclear body|peptidyl-serine phosphorylation|keratinocyte differentiation|positive regulation of protein binding|protein-containing complex|positive regulation of peptidyl-serine phosphorylation|organ growth|hippo signaling|intracellular signal transduction|identical protein binding|protein homodimerization activity|positive regulation of apoptotic process|regulation of MAPK cascade|protein serine/threonine kinase activator activity|positive regulation of fat cell differentiation|negative regulation of organ growth|protein autophosphorylation|epithelial cell proliferation|negative regulation of epithelial cell proliferation|protein stabilization|protein tetramerization|canonical Wnt signaling pathway|primitive hemopoiesis|cell differentiation involved in embryonic placenta development|regulation of cell differentiation involved in embryonic placenta development|RNA polymerase II-specific DNA-binding transcription factor binding|negative regulation of canonical Wnt signaling pathway|hepatocyte apoptotic process|protein serine kinase activity|positive regulation of extrinsic apoptotic signaling pathway via death domain receptors|positive regulation of hepatocyte apoptotic process|positive regulation of substrate-dependent cell migration, cell attachment to substrate","WP4223,WP382,WP4255","Ras signaling|MAPK signaling pathway|Non-small cell lung cancer","R-HSA-162582,R-HSA-2028269","Signal Transduction|Signaling by Hippo"]
["STMND1",0,0,0,0,0,0,0,0,0,0.0169025327763314,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,401236,"stathmin domain containing 1","protein_coding",null,null,"GO:0005737,GO:0007019,GO:0015631,GO:0031110,GO:0031175,GO:0043005","cytoplasm|microtubule depolymerization|tubulin binding|regulation of microtubule polymerization or depolymerization|neuron projection development|neuron projection"]
["STRIT1",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.0318539419801088,0,0,0,0,0,0,0,0,0,0,100507537,"small transmembrane regulator of ion transport 1","protein_coding",null,null,"GO:0005515,GO:0008047,GO:0031449,GO:0033017,GO:1901894,GO:1902082","protein binding|enzyme activator activity|regulation of slow-twitch skeletal muscle fiber contraction|sarcoplasmic reticulum membrane|regulation of ATPase-coupled calcium transmembrane transporter activity|positive regulation of calcium ion import into sarcoplasmic reticulum"]
["STXBP4",0.77179642552761,0.648169386566623,0.685772781604641,0.506682943456459,0.748181526455287,0.654293769059572,0.674359787561085,0.543589807672197,0.768620968873605,0.502933648097243,0.593337155632584,0.65169808031713,0.701933116372192,0.541640421211,0.89435966876131,0.725972469100349,0.493218048673489,0.494497026818064,0.626977475105121,0.631732981687156,0.659084106608521,0.609895193290127,0.825427396420012,0.74654358033174,0.623983541467821,0.477256546154613,0.675724347218904,0.489477181590492,252983,"syntaxin binding protein 4","protein_coding",null,null,"GO:0005515,GO:0006605,GO:0006974,GO:0008286,GO:0010827,GO:0010838,GO:0019905,GO:0031410,GO:0045335,GO:0050821,GO:0061178,GO:0070062,GO:0071346,GO:0098685,GO:0099072,GO:1902808","protein binding|protein targeting|DNA damage response|insulin receptor signaling pathway|regulation of glucose transmembrane transport|positive regulation of keratinocyte proliferation|syntaxin binding|cytoplasmic vesicle|phagocytic vesicle|protein stabilization|regulation of insulin secretion involved in cellular response to glucose stimulus|extracellular exosome|cellular response to type II interferon|Schaffer collateral - CA1 synapse|regulation of postsynaptic membrane neurotransmitter receptor levels|positive regulation of cell cycle G1/S phase transition","WP481","Insulin signaling"]
["SULT2B1",0.268602856436586,0.0547469745054929,0.252173975610034,0.368008246063811,0.37495343516562,0.19818210532918,0.214803462339787,0.206950168555456,0.443863960015244,0.25869897852116,0.126302728905439,0.193026279125084,0.255438934842952,0.109748545352012,0.32117034078212,0.236485144279651,0.184460982860772,0.372793144468988,0.159588313984205,0.221395031264744,0.271629929027669,0.328264604888354,0.18940725117231,0.412370572006292,0.532598217788097,0.364601466103622,0.185658607793194,0.270554746520957,6820,"sulfotransferase family 2B member 1","protein_coding","hsa00140","Steroid hormone biosynthesis","GO:0003676,GO:0005515,GO:0005634,GO:0005737,GO:0005783,GO:0005829,GO:0008146,GO:0008202,GO:0008203,GO:0008285,GO:0015485,GO:0036094,GO:0043231,GO:0045606,GO:0050294,GO:0050427,GO:0051922,GO:0051923,GO:0070062,GO:1990239","nucleic acid binding|protein binding|nucleus|cytoplasm|endoplasmic reticulum|cytosol|sulfotransferase activity|steroid metabolic process|cholesterol metabolic process|negative regulation of cell population proliferation|cholesterol binding|small molecule binding|intracellular membrane-bounded organelle|positive regulation of epidermal cell differentiation|steroid sulfotransferase activity|3'-phosphoadenosine 5'-phosphosulfate metabolic process|cholesterol sulfotransferase activity|sulfation|extracellular exosome|steroid hormone binding","WP702,WP4545,WP692,WP716","Metapathway biotransformation Phase I and II|Oxysterols derived from cholesterol|Sulfation biotransformation reaction|Vitamin A and carotenoid metabolism","R-HSA-1430728,R-HSA-156580,R-HSA-156584,R-HSA-211859","Metabolism|Phase II - Conjugation of compounds|Cytosolic sulfonation of small molecules|Biological oxidations"]
["SUPT3H",0.532731526388203,0.535671272288359,0.588268637747225,0.635001241637634,0.527999434287782,0.664633868714065,0.655611122801855,0.52737006318916,0.668543778268282,0.532634979774988,0.510546120029019,0.816719509642743,0.509035448286329,0.744911624249169,0.559136425985185,0.661454108363015,0.607309924232327,0.636098579953437,0.511118479727107,0.529362131463324,0.608172236477221,0.725812695957032,0.543454072780632,0.552683322930682,0.623734650204634,0.568862008896287,0.655439881747599,0.624844141676578,8464,"SPT3 homolog%2C SAGA and STAGA complex component","protein_coding","hsa05202","Transcriptional misregulation in cancer","GO:0000124,GO:0003713,GO:0005634,GO:0005654,GO:0006282,GO:0006355,GO:0006357,GO:0006366,GO:0033276,GO:0043484,GO:0043966,GO:0045893,GO:0046982","SAGA complex|transcription coactivator activity|nucleus|nucleoplasm|regulation of DNA repair|regulation of DNA-templated transcription|regulation of transcription by RNA polymerase II|transcription by RNA polymerase II|transcription factor TFTC complex|regulation of RNA splicing|histone H3 acetylation|positive regulation of DNA-templated transcription|protein heterodimerization activity",null,null,"R-HSA-3214847,R-HSA-3247509,R-HSA-4839726","HATs acetylate histones|Chromatin modifying enzymes|Chromatin organization"]
["SUV39H2",2.80749373584081,2.35184300075209,1.3714060897451,1.88615170048407,2.06100495131745,1.79996481384753,1.26979432408568,1.87959967929954,2.07138045080842,1.40689122934476,1.48097235145136,2.02164795273988,1.70087643153659,0.937489887139914,1.16631424014748,1.14854870394263,3.4596795893283,2.32735863319061,2.57498864007968,3.0423528153047,3.28205735374977,3.09533554835579,3.18665308266943,3.04915202348968,3.46160684109564,2.87751322293319,2.26166832713231,3.04130330713408,79723,"SUV39H2 histone lysine methyltransferase","protein_coding","hsa00310","Lysine degradation","GO:0000122,GO:0000775,GO:0000785,GO:0000976,GO:0005515,GO:0005634,GO:0005654,GO:0006325,GO:0006338,GO:0007049,GO:0007623,GO:0008270,GO:0030154,GO:0032259,GO:0044725,GO:0045814,GO:0045892,GO:0046974,GO:0071456,GO:0140938,GO:0140949,GO:1904047,GO:1990756","negative regulation of transcription by RNA polymerase II|chromosome, centromeric region|chromatin|transcription cis-regulatory region binding|protein binding|nucleus|nucleoplasm|chromatin organization|chromatin remodeling|cell cycle|circadian rhythm|zinc ion binding|cell differentiation|methylation|epigenetic programming in the zygotic pronuclei|negative regulation of gene expression, epigenetic|negative regulation of DNA-templated transcription|histone H3K9 methyltransferase activity|cellular response to hypoxia|histone H3 methyltransferase activity|histone H3K9 trimethyltransferase activity|S-adenosyl-L-methionine binding|ubiquitin ligase-substrate adaptor activity","WP3594,WP2369","Circadian rhythm genes|Histone modifications","R-HSA-3214841,R-HSA-3247509,R-HSA-4839726","PKMTs methylate histone lysines|Chromatin modifying enzymes|Chromatin organization"]
["SYN3-AS1",0,0,0.00633795634739541,0.00647447515301347,0,0.00633940891987111,0,0.00661987994491305,0,0,0,0,0,0,0,0.00640084817108612,0,0,0,0,0,0,0,0,0,0,0,0,105373004,null,"non_coding"]
["SYNRG",7.76825445379776,7.44201392306398,5.44362322134136,5.86138579737439,7.8272662348065,6.35963242957878,5.94810168725889,5.6097117117447,7.31452589629769,6.14322349501428,5.37708072223794,6.70123750604887,7.52915531308465,6.39454633917842,6.57238769967038,7.36842672362792,5.55678892338377,6.06533295814345,4.84278015062017,6.10377871182501,5.32629954706233,5.56749799562054,5.56797154559698,6.01633516532213,5.8254325642001,4.99059009304507,4.96543294846783,4.9989782017829,11276,"synergin gamma","protein_coding",null,null,"GO:0005515,GO:0005737,GO:0005794,GO:0006886,GO:0006897,GO:0030121,GO:0030130,GO:0048471","protein binding|cytoplasm|Golgi apparatus|intracellular protein transport|endocytosis|AP-1 adaptor complex|clathrin coat of trans-Golgi network vesicle|perinuclear region of cytoplasm","WP5323,WP5287","Fatty Acids and Lipoproteins Transport in Hepatocytes|17q12 copy number variation syndrome"]
["SZT2",3.38266840516153,4.13324985901682,3.56711371686683,3.8084572837989,3.66766160790168,3.7844319329623,3.15771990259939,3.68418672069908,3.62142391580838,4.69150932601296,3.49689608103298,3.81334211468271,3.21337960377481,3.86327019688006,3.31224692633381,3.4800949453864,2.69186821509153,3.02576268486923,2.27059829010438,3.12869126118808,2.66003419698374,2.61050034338259,2.62384445952594,2.57138118615816,2.96050658084036,2.62003511636676,2.26492703709775,2.75180927236358,23334,"SZT2 subunit of KICSTOR complex","protein_coding",null,null,"GO:0003674,GO:0005515,GO:0005765,GO:0005777,GO:0007417,GO:0009791,GO:0021540,GO:0034198,GO:0042149,GO:0043473,GO:0061462,GO:0140007,GO:1901668,GO:1904262","molecular_function|protein binding|lysosomal membrane|peroxisome|central nervous system development|post-embryonic development|corpus callosum morphogenesis|cellular response to amino acid starvation|cellular response to glucose starvation|pigmentation|protein localization to lysosome|KICSTOR complex|regulation of superoxide dismutase activity|negative regulation of TORC1 signaling",null,null,"R-HSA-2262752,R-HSA-8953897,R-HSA-9639288,R-HSA-9711097","Cellular responses to stress|Cellular responses to stimuli|Amino acids regulate mTORC1|Cellular response to starvation"]
["TAB3-AS1",0.0916878069225956,0,0,0.0879339431496013,0.0895934653754586,0,0,0,0.0922255048538034,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,727682,"TAB3 antisense RNA 1","non_coding"]
["TAF5",1.78660401681881,1.60494812649732,1.05609528031309,1.59446714835303,1.30934567931952,1.61557472904125,1.25016406011964,1.36261870026583,1.77212198986034,1.5295365897924,1.15124663343694,1.75586393304777,1.15629422714656,0.76491155279222,1.05384189160694,0.799931220683947,2.09942521518005,1.87502330768768,1.97228761161005,1.90892923551374,1.67848237314172,1.83189019091194,1.46980956801096,2.10102052991573,2.18949976362093,1.76832829812837,1.92896388130759,1.48521466712962,6877,"TATA-box binding protein associated factor 5","protein_coding","hsa03022","Basal transcription factors","GO:0000785,GO:0005515,GO:0005634,GO:0005654,GO:0005669,GO:0005730,GO:0006282,GO:0006352,GO:0006357,GO:0006367,GO:0015629,GO:0016251,GO:0033276,GO:0042789,GO:0042802,GO:0045893,GO:0051123,GO:0060261","chromatin|protein binding|nucleus|nucleoplasm|transcription factor TFIID complex|nucleolus|regulation of DNA repair|DNA-templated transcription initiation|regulation of transcription by RNA polymerase II|transcription initiation at RNA polymerase II promoter|actin cytoskeleton|RNA polymerase II general transcription initiation factor activity|transcription factor TFTC complex|mRNA transcription by RNA polymerase II|identical protein binding|positive regulation of DNA-templated transcription|RNA polymerase II preinitiation complex assembly|positive regulation of transcription initiation by RNA polymerase II","WP2853,WP405","Endoderm differentiation|Eukaryotic transcription initiation","R-HSA-162587,R-HSA-162599,R-HSA-162906,R-HSA-1643685,R-HSA-167161,R-HSA-167162,R-HSA-167172,R-HSA-212436,R-HSA-3700989,R-HSA-5633007,R-HSA-5663205,R-HSA-674695,R-HSA-6804756,R-HSA-6807505,R-HSA-6807505,R-HSA-73776,R-HSA-73779,R-HSA-73857,R-HSA-73857,R-HSA-74160,R-HSA-74160,R-HSA-75953,R-HSA-76042,R-HSA-9824446","HIV Life Cycle|Late Phase of HIV Life Cycle|HIV Infection|Disease|HIV Transcription Initiation|RNA Polymerase II HIV Promoter Escape|Transcription of the HIV genome|Generic Transcription Pathway|Transcriptional Regulation by TP53|Regulation of TP53 Activity|Infectious disease|RNA Polymerase II Pre-transcription Events|Regulation of TP53 Activity through Phosphorylation|RNA polymerase II transcribes snRNA genes|RNA polymerase II transcribes snRNA genes|RNA Polymerase II Promoter Escape|RNA Polymerase II Transcription Pre-Initiation And Promoter Opening|RNA Polymerase II Transcription|RNA Polymerase II Transcription|Gene expression (Transcription)|Gene expression (Transcription)|RNA Polymerase II Transcription Initiation|RNA Polymerase II Transcription Initiation And Promoter Clearance|Viral Infection Pathways"]
["TAOK3",8.56839415971387,8.65886948350961,7.8042414383905,6.94608850926653,8.37267409089291,7.58437279690516,7.50239442518788,7.18309724379895,6.88937442519537,6.30112213117515,5.43494883268154,6.30904646731122,7.01486473164146,6.4698705543095,6.72461468129613,6.50154943086355,8.57084011913789,7.63318912553731,7.01010586451602,8.56489446938423,8.748238552917,7.78932441975848,8.23363161619738,8.66319053076452,8.76402726260656,7.29671188614382,8.17346305399071,6.8384831239126,51347,"TAO kinase 3","protein_coding","hsa04010","MAPK signaling pathway","GO:0000165,GO:0004674,GO:0004860,GO:0005515,GO:0005524,GO:0005737,GO:0005886,GO:0006281,GO:0006468,GO:0006974,GO:0007095,GO:0016740,GO:0032874,GO:0043408,GO:0043507,GO:0046329,GO:0046330,GO:0046777,GO:0048812,GO:0106310","MAPK cascade|protein serine/threonine kinase activity|protein kinase inhibitor activity|protein binding|ATP binding|cytoplasm|plasma membrane|DNA repair|protein phosphorylation|DNA damage response|mitotic G2 DNA damage checkpoint signaling|transferase activity|positive regulation of stress-activated MAPK cascade|regulation of MAPK cascade|positive regulation of JUN kinase activity|negative regulation of JNK cascade|positive regulation of JNK cascade|protein autophosphorylation|neuron projection morphogenesis|protein serine kinase activity","WP382","MAPK signaling pathway","R-HSA-162582,R-HSA-194315,R-HSA-9012999,R-HSA-9013149,R-HSA-9013404,R-HSA-9013423,R-HSA-9716542","Signal Transduction|Signaling by Rho GTPases|RHO GTPase cycle|RAC1 GTPase cycle|RAC2 GTPase cycle|RAC3 GTPase cycle|Signaling by Rho GTPases, Miro GTPases and RHOBTB3"]
["TAS2R14",0.0581579616725849,0.0691473383497102,0.163802328123947,0.13944217522105,0.0568295120180903,0.0409599673414973,0.0271304265181051,0.228118063603346,0.248620859363165,0.028006785700588,0.0410206505113598,0.160907289313817,0.138269264699625,0.152477864834174,0.121694802804444,0.234355973409653,0.0139788393160402,0.0403586352272252,0.147814778414592,0.167777787986496,0.0686156149377697,0.124382893707696,0.143536778801023,0.198865576918794,0.129733095699076,0.0828907863876358,0.211043967596632,0.0820128196034402,50840,"PRH1-TAS2R14 readthrough","protein_coding","hsa04742","Taste transduction","GO:0001580,GO:0004930,GO:0005886,GO:0007186,GO:0008527,GO:0016020,GO:0033038","detection of chemical stimulus involved in sensory perception of bitter taste|G protein-coupled receptor activity|plasma membrane|G protein-coupled receptor signaling pathway|taste receptor activity|membrane|bitter taste receptor activity",null,null,"R-HSA-162582,R-HSA-372790,R-HSA-388396,R-HSA-418594,R-HSA-420499,R-HSA-500792,R-HSA-9709957,R-HSA-9709957,R-HSA-9717189,R-HSA-9717189,R-HSA-9717207,R-HSA-9717207","Signal Transduction|Signaling by GPCR|GPCR downstream signalling|G alpha (i) signalling events|Class C/3 (Metabotropic glutamate/pheromone receptors)|GPCR ligand binding|Sensory Perception|Sensory Perception|Sensory perception of taste|Sensory perception of taste|Sensory perception of sweet, bitter, and umami (glutamate) taste|Sensory perception of sweet, bitter, and umami (glutamate) taste"]
["TAS2R8",0.0218092356272193,0,0,0,0.0426221340135677,0,0,0.0855442738512551,0,0,0.0615309757670397,0,0,0,0,0,0,0,0,0,0.0205846844813309,0,0.0215305168201534,0,0,0.0207226965969089,0,0,50836,"taste 2 receptor member 8","protein_coding","hsa04742","Taste transduction","GO:0001580,GO:0004930,GO:0005515,GO:0005886,GO:0007186,GO:0008527,GO:0016020,GO:0033038","detection of chemical stimulus involved in sensory perception of bitter taste|G protein-coupled receptor activity|protein binding|plasma membrane|G protein-coupled receptor signaling pathway|taste receptor activity|membrane|bitter taste receptor activity",null,null,"R-HSA-162582,R-HSA-372790,R-HSA-388396,R-HSA-418594,R-HSA-420499,R-HSA-500792,R-HSA-9709957,R-HSA-9709957,R-HSA-9717189,R-HSA-9717189,R-HSA-9717207,R-HSA-9717207","Signal Transduction|Signaling by GPCR|GPCR downstream signalling|G alpha (i) signalling events|Class C/3 (Metabotropic glutamate/pheromone receptors)|GPCR ligand binding|Sensory Perception|Sensory Perception|Sensory perception of taste|Sensory perception of taste|Sensory perception of sweet, bitter, and umami (glutamate) taste|Sensory perception of sweet, bitter, and umami (glutamate) taste"]
["TBC1D20",15.9039250119959,18.4761005287012,17.0666329407372,16.0650341209349,16.8824971972664,16.547918726897,16.3338927684758,17.1376702897866,17.3602094731335,19.1803994196394,17.8354216607324,18.3256056475787,17.178292935924,19.1534732703178,18.7568396196821,18.0504651017215,13.8831520277058,14.2563618368206,12.3113884322629,15.2993688243925,13.60063733956,14.1857350421989,12.84003487385,13.806034835262,14.9818434132847,13.6688320509891,13.3469206509137,13.3761878091456,128637,"TBC1 domain family member 20","protein_coding",null,null,"GO:0000139,GO:0001675,GO:0005096,GO:0005515,GO:0005783,GO:0005789,GO:0006888,GO:0007030,GO:0019068,GO:0031267,GO:0031965,GO:0033116,GO:0034389,GO:0043547,GO:0044829,GO:0046726,GO:0070309,GO:0072520,GO:0090110,GO:1902017,GO:1902953","Golgi membrane|acrosome assembly|GTPase activator activity|protein binding|endoplasmic reticulum|endoplasmic reticulum membrane|endoplasmic reticulum to Golgi vesicle-mediated transport|Golgi organization|virion assembly|small GTPase binding|nuclear membrane|endoplasmic reticulum-Golgi intermediate compartment membrane|lipid droplet organization|positive regulation of GTPase activity|positive regulation by host of viral genome replication|positive regulation by virus of viral protein levels in host cell|lens fiber cell morphogenesis|seminiferous tubule development|COPII-coated vesicle cargo loading|regulation of cilium assembly|positive regulation of ER to Golgi vesicle-mediated transport",null,null,"R-HSA-199977,R-HSA-199991,R-HSA-204005,R-HSA-392499,R-HSA-446203,R-HSA-5653656,R-HSA-597592,R-HSA-8854214,R-HSA-9007101,R-HSA-948021","ER to Golgi Anterograde Transport|Membrane Trafficking|COPII-mediated vesicle transport|Metabolism of proteins|Asparagine N-linked glycosylation|Vesicle-mediated transport|Post-translational protein modification|TBC/RABGAPs|Rab regulation of trafficking|Transport to the Golgi and subsequent modification"]
["TBCA",34.9942299923749,31.1944262188856,38.9618139787768,41.6643915758033,31.3308496018416,33.2366854599426,40.2833533903214,36.64501069483,35.4451331167033,24.0910379514146,38.0157020182578,34.8608401604156,33.7120854651015,36.3581607539985,35.8484420096492,31.379796990628,42.1734558201191,41.9529010517366,53.1618163978946,35.9358876890501,42.1145349283606,43.2570713135982,55.7114360000388,45.3386837714496,42.0687881807848,47.9984765740101,59.8623606460571,48.1789510561982,6902,"tubulin folding cofactor A","protein_coding",null,null,"GO:0003723,GO:0005515,GO:0005730,GO:0005737,GO:0005874,GO:0006457,GO:0007021,GO:0007023,GO:0015630,GO:0015631,GO:0048487,GO:0051087","RNA binding|protein binding|nucleolus|cytoplasm|microtubule|protein folding|tubulin complex assembly|post-chaperonin tubulin folding pathway|microtubule cytoskeleton|tubulin binding|beta-tubulin binding|protein-folding chaperone binding","WP3888","VEGFA-VEGFR2 signaling","R-HSA-389977,R-HSA-391251,R-HSA-392499","Post-chaperonin tubulin folding pathway|Protein folding|Metabolism of proteins"]
["TBKBP1",4.29158895726525,5.3744842751456,7.17652175473596,6.7071794838877,5.07020894382262,6.29629156212222,6.32908284532746,6.38964778709361,4.643943677652,7.87256682690646,7.88942554760929,6.27068671737725,5.19887053049311,6.82751083397314,5.80132246596024,5.59622617565984,2.43631743643564,3.19901488904441,3.37481554601605,2.77984414215579,2.9463582446984,3.2514821369537,2.21160060786415,2.68582984644248,2.77757093407576,3.24527592427995,2.41659719190215,2.9889506660223,9755,"TBK1 binding protein 1","protein_coding","hsa04622","RIG-I-like receptor signaling pathway","GO:0005515,GO:0005737,GO:0007249,GO:0046872,GO:0051607,GO:0060337,GO:1902554","protein binding|cytoplasm|canonical NF-kappaB signal transduction|metal ion binding|defense response to virus|type I interferon-mediated signaling pathway|serine/threonine protein kinase complex","WP3865","Novel intracellular components of RIG-I-like receptor pathway"]
["TBXA2R",1.76838356312341,1.29471750885994,1.30524015259836,1.77966611830567,1.42104439039624,1.38201440088745,1.04746045290908,1.5914668521775,1.45694007516778,1.91047496923948,1.7724745129889,1.50407626236256,0.918306041886395,1.07034830601275,0.957539037517403,0.849379015766211,1.16329041068692,1.53934140249063,1.56986289011557,1.1243537585297,1.4769266799937,1.45974089154064,0.964775303554429,1.19913404798647,1.35528251247136,1.56973755939433,1.12018166693867,1.49842412268987,6915,"thromboxane A2 receptor","protein_coding","hsa04020,hsa04080,hsa04611","Calcium signaling pathway|Neuroactive ligand-receptor interaction|Platelet activation","GO:0001669,GO:0004961,GO:0005085,GO:0005515,GO:0005886,GO:0006939,GO:0006954,GO:0007186,GO:0007189,GO:0007204,GO:0007584,GO:0009410,GO:0016607,GO:0019932,GO:0030194,GO:0033574,GO:0038193,GO:0045471,GO:0045766,GO:0045777,GO:0045907,GO:0045987,GO:0071222,GO:0090051","acrosomal vesicle|thromboxane A2 receptor activity|guanyl-nucleotide exchange factor activity|protein binding|plasma membrane|smooth muscle contraction|inflammatory response|G protein-coupled receptor signaling pathway|adenylate cyclase-activating G protein-coupled receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|response to nutrient|response to xenobiotic stimulus|nuclear speck|second-messenger-mediated signaling|positive regulation of blood coagulation|response to testosterone|thromboxane A2 signaling pathway|response to ethanol|positive regulation of angiogenesis|positive regulation of blood pressure|positive regulation of vasoconstriction|positive regulation of smooth muscle contraction|cellular response to lipopolysaccharide|negative regulation of cell migration involved in sprouting angiogenesis","WP98,WP455,WP4719,WP247","Prostaglandin synthesis and regulation|GPCRs, class A rhodopsin-like|Eicosanoid metabolism via cyclooxygenases (COX)|Small ligand GPCRs","R-HSA-109582,R-HSA-162582,R-HSA-372790,R-HSA-373076,R-HSA-388396,R-HSA-391903,R-HSA-391908,R-HSA-392518,R-HSA-416476,R-HSA-416482,R-HSA-428930,R-HSA-500792,R-HSA-76002","Hemostasis|Signal Transduction|Signaling by GPCR|Class A/1 (Rhodopsin-like receptors)|GPCR downstream signalling|Eicosanoid ligand-binding receptors|Prostanoid ligand receptors|Signal amplification|G alpha (q) signalling events|G alpha (12/13) signalling events|Thromboxane signalling through TP receptor|GPCR ligand binding|Platelet activation, signaling and aggregation"]
["TCF7L2",2.5347800579968,2.93386307296147,2.86715933102151,2.51886912982762,2.97424590909934,2.87737583267774,2.53113662552059,2.35083611632134,2.75443590516159,3.08841444807409,2.71410159801426,2.47338611043181,3.29151864411087,2.45057076538541,3.44132497311162,3.20930139479846,1.8449058856988,2.02980463781217,1.79700914733263,2.25150441695625,1.78233205759463,1.90623360741908,2.70840566987415,1.62607691696744,1.86207166474124,1.84264527768692,2.09822973040899,1.82791336864631,6934,"transcription factor 7 like 2","protein_coding","hsa04310,hsa04390,hsa04520,hsa04916,hsa05200,hsa05210,hsa05225,hsa05226,hsa05216,hsa05221,hsa05217,hsa05215,hsa05213,hsa05224,hsa05167,hsa05165,hsa05132,hsa05412,hsa04936,hsa04934","Wnt signaling pathway|Hippo signaling pathway|Adherens junction|Melanogenesis|Pathways in cancer|Colorectal cancer|Hepatocellular carcinoma|Gastric cancer|Thyroid cancer|Acute myeloid leukemia|Basal cell carcinoma|Prostate cancer|Endometrial cancer|Breast cancer|Kaposi sarcoma-associated herpesvirus infection|Human papillomavirus infection|Salmonella infection|Arrhythmogenic right ventricular cardiomyopathy|Alcoholic liver disease|Cushing syndrome","GO:0000122,GO:0000785,GO:0000976,GO:0000978,GO:0000981,GO:0001568,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0008013,GO:0009749,GO:0010909,GO:0016605,GO:0016922,GO:0019901,GO:0031016,GO:0032024,GO:0032092,GO:0032350,GO:0032993,GO:0042593,GO:0043433,GO:0043565,GO:0043570,GO:0044334,GO:0045295,GO:0045444,GO:0045721,GO:0045892,GO:0045944,GO:0048625,GO:0048660,GO:0050679,GO:0051897,GO:0060070,GO:0061629,GO:0070016,GO:0070369,GO:0071664,GO:0090090,GO:1900182,GO:1990841,GO:1990907,GO:2000675,GO:2001237","negative regulation of transcription by RNA polymerase II|chromatin|transcription cis-regulatory region binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|blood vessel development|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|beta-catenin binding|response to glucose|positive regulation of heparan sulfate proteoglycan biosynthetic process|PML body|nuclear receptor binding|protein kinase binding|pancreas development|positive regulation of insulin secretion|positive regulation of protein binding|regulation of hormone metabolic process|protein-DNA complex|glucose homeostasis|negative regulation of DNA-binding transcription factor activity|sequence-specific DNA binding|maintenance of DNA repeat elements|canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition|gamma-catenin binding|fat cell differentiation|negative regulation of gluconeogenesis|negative regulation of DNA-templated transcription|positive regulation of transcription by RNA polymerase II|myoblast fate commitment|regulation of smooth muscle cell proliferation|positive regulation of epithelial cell proliferation|positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction|canonical Wnt signaling pathway|RNA polymerase II-specific DNA-binding transcription factor binding|armadillo repeat domain binding|beta-catenin-TCF7L2 complex|catenin-TCF7L2 complex|negative regulation of canonical Wnt signaling pathway|positive regulation of protein localization to nucleus|promoter-specific chromatin binding|beta-catenin-TCF complex|negative regulation of type B pancreatic cell apoptotic process|negative regulation of extrinsic apoptotic signaling pathway","WP4216,WP428,WP4262,WP399,WP4540,WP2118,WP4844,WP3678,WP4258,WP363,WP710,WP4879,WP4336,WP4155,WP5087","Chromosomal and microsatellite instability in colorectal cancer |Wnt signaling|Breast cancer pathway|Wnt signaling pathway and pluripotency|Hippo signaling regulation pathways|Arrhythmogenic right ventricular cardiomyopathy|Influence of laminopathies on Wnt signaling|Amplification and expansion of oncogenic pathways as metastatic traits|lncRNA in canonical Wnt signaling and colorectal cancer|Wnt signaling pathway|DNA damage response (only ATM dependent)|Overlap between signal transduction pathways contributing to LMNA laminopathies|ncRNAs involved in Wnt signaling in hepatocellular carcinoma|Endometrial cancer|Pleural mesothelioma","R-HSA-1266738,R-HSA-162582,R-HSA-162582,R-HSA-1643685,R-HSA-195253,R-HSA-195253,R-HSA-195721,R-HSA-195721,R-HSA-201681,R-HSA-201681,R-HSA-201722,R-HSA-201722,R-HSA-212436,R-HSA-2980736,R-HSA-3769402,R-HSA-381771,R-HSA-3858494,R-HSA-392499,R-HSA-400508,R-HSA-4086398,R-HSA-4411364,R-HSA-4641265,R-HSA-4641265,R-HSA-4791275,R-HSA-5339700,R-HSA-5663202,R-HSA-73857,R-HSA-74160,R-HSA-8853884,R-HSA-8878159,R-HSA-8951430,R-HSA-9758941,R-HSA-9823730","Developmental Biology|Signal Transduction|Signal Transduction|Disease|Degradation of beta-catenin by the destruction complex|Degradation of beta-catenin by the destruction complex|Signaling by WNT|Signaling by WNT|TCF dependent signaling in response to WNT|TCF dependent signaling in response to WNT|Formation of the beta-catenin:TCF transactivating complex|Formation of the beta-catenin:TCF transactivating complex|Generic Transcription Pathway|Peptide hormone metabolism|Deactivation of the beta-catenin transactivating complex|Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)|Beta-catenin independent WNT signaling|Metabolism of proteins|Incretin synthesis, secretion, and inactivation|Ca2+ pathway|Binding of TCF/LEF:CTNNB1 to target gene promoters|Repression of WNT target genes|Repression of WNT target genes|Signaling by WNT in cancer|Signaling by TCF7L2 mutants|Diseases of signal transduction by growth factor receptors and second messengers|RNA Polymerase II Transcription|Gene expression (Transcription)|Transcriptional Regulation by VENTX|Transcriptional regulation by RUNX3|RUNX3 regulates WNT signaling|Gastrulation|Formation of definitive endoderm","HMG"]
["TDRP",2.74019089347848,2.99890270329078,3.16924403408337,3.01587039435377,2.70179436767572,3.31723061901268,2.66438066817822,3.05932096582189,2.31625513200798,1.80448251934753,2.2975583456038,2.11746754909796,2.58234997892748,2.69112438901284,2.82469063410879,3.02852819079787,1.61087076627787,1.84809432028257,1.80024131288299,1.61117533787951,1.87742911039832,2.02409737745763,2.39554357751826,1.65302335358949,1.56291438560192,1.85080456415552,1.86892163148097,1.69153323763837,157695,"testis development related protein","protein_coding",null,null,"GO:0003674,GO:0005634,GO:0005737,GO:0005829,GO:0007283,GO:0043231","molecular_function|nucleus|cytoplasm|cytosol|spermatogenesis|intracellular membrane-bounded organelle"]
["TENM3",1.97240599282266,2.0472369914461,1.68283236483795,1.38942403008961,1.86197993201864,1.67671913550647,1.53030233006448,1.34823925113757,1.53844928173838,1.71304457471691,1.46225191260571,1.33918279069335,1.58176488899434,1.16565759943483,1.49964239923176,1.54423296906167,1.14224523468963,1.08219167661151,0.663080984519263,1.14911631581919,0.794743222670742,0.942904298213756,0.772047297365132,0.984904289311407,1.07037298161374,0.727736413687187,0.685332097496598,0.850153942056098,55714,"teneurin transmembrane protein 3","protein_coding",null,null,"GO:0005886,GO:0007156,GO:0007157,GO:0007165,GO:0010976,GO:0016020,GO:0030424,GO:0042803,GO:0043005,GO:0046982,GO:0048593,GO:0048666,GO:0050839,GO:1903385","plasma membrane|homophilic cell adhesion via plasma membrane adhesion molecules|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules|signal transduction|positive regulation of neuron projection development|membrane|axon|protein homodimerization activity|neuron projection|protein heterodimerization activity|camera-type eye morphogenesis|neuron development|cell adhesion molecule binding|regulation of homophilic cell adhesion"]
["TET2-AS1",0.0357509485878555,0,0,0,0.0349343220429507,0,0,0,0,0,0,0.03596842469108,0,0.0340841525684301,0,0,0,0,0,0,0,0,0,0,0,0.0339698315567366,0,0,104384744,"TET2 antisense RNA 1","non_coding"]
["TEX19",0,0.0724971717061429,0,0,0.0124130437419344,0.0119289631560063,0,0.0747403787559976,0.0127777089665495,0.0122348210859778,0,0.0127804864359445,0,0,0,0,0,0.0587691719378539,0.0469623167133329,0.0122156777775276,0,0,0,0.0124106900366044,0,0,0.0122926646536021,0.023884977622491,400629,"testis expressed 19","protein_coding",null,null,"GO:0001890,GO:0005515,GO:0005634,GO:0005737,GO:0007131,GO:0007140,GO:0007283,GO:0008584,GO:0010526,GO:0030154,GO:0034584","placenta development|protein binding|nucleus|cytoplasm|reciprocal meiotic recombination|male meiotic nuclear division|spermatogenesis|male gonad development|retrotransposon silencing|cell differentiation|piRNA binding"]
["TFAP4",3.08923423438523,4.65929133437233,5.74635643202974,5.5655499141191,3.17853689442702,5.01565840716179,6.66234551719183,5.12431884208516,3.65912345784108,4.35640002209539,5.59327773148896,4.16339973343162,3.69746131982344,4.78940144273591,4.95833547849139,5.28326373673618,3.25694479413151,4.49679631134049,5.3633866250993,4.6087078848515,3.81503798927115,4.43666365952729,4.86440557669809,4.28739051106733,3.32035207585699,4.70018280571318,5.20583156971566,5.1480099805414,7023,"transcription factor AP-4","protein_coding","hsa05205","Proteoglycans in cancer","GO:0000785,GO:0000976,GO:0000978,GO:0000981,GO:0001228,GO:0003677,GO:0005515,GO:0005634,GO:0005654,GO:0005739,GO:0006357,GO:0006978,GO:0008285,GO:0010629,GO:0017053,GO:0042803,GO:0042826,GO:0043065,GO:0043392,GO:0043565,GO:0043922,GO:0043923,GO:0045736,GO:0045892,GO:0045893,GO:0045944,GO:0065003,GO:0070888,GO:0071549,GO:1901990,GO:1990837","chromatin|transcription cis-regulatory region binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA binding|protein binding|nucleus|nucleoplasm|mitochondrion|regulation of transcription by RNA polymerase II|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|negative regulation of cell population proliferation|negative regulation of gene expression|transcription repressor complex|protein homodimerization activity|histone deacetylase binding|positive regulation of apoptotic process|negative regulation of DNA binding|sequence-specific DNA binding|negative regulation by host of viral transcription|positive regulation by host of viral transcription|negative regulation of cyclin-dependent protein serine/threonine kinase activity|negative regulation of DNA-templated transcription|positive regulation of DNA-templated transcription|positive regulation of transcription by RNA polymerase II|protein-containing complex assembly|E-box binding|cellular response to dexamethasone stimulus|regulation of mitotic cell cycle phase transition|sequence-specific double-stranded DNA binding","WP5180","DYRK1A involvement regarding cell proliferation in brain development",null,null,"bHLH"]
["TFEC",0,0,0,0,0,0,0,0.00327873736294192,0,0,0,0.0134558135534975,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,22797,"transcription factor EC","protein_coding",null,null,"GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001227,GO:0001228,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006357,GO:0034605,GO:0045944,GO:0046983,GO:1990837","negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|protein binding|nucleus|nucleoplasm|cytosol|regulation of transcription by RNA polymerase II|cellular response to heat|positive regulation of transcription by RNA polymerase II|protein dimerization activity|sequence-specific double-stranded DNA binding"]
["THAP4",14.7575772313416,18.2401557339288,19.4316522401951,19.7713587677016,15.0029261752401,19.223794721904,17.939562703108,18.4719863044336,15.3713159591978,21.1914844176351,19.6195375114454,16.0363774794823,14.7966352330995,16.5679648123844,14.8044534525662,15.0350359705862,13.4375923008145,16.8496301954988,17.7424456129159,15.5648598872147,15.6167360771899,16.6455893560237,14.2849028043885,12.3093037361452,13.999303979813,19.4613851378583,14.1414101828479,18.24080169809,51078,"THAP domain containing 4","protein_coding",null,null,"GO:0003677,GO:0005515,GO:0005575,GO:0005654,GO:0005829,GO:0006570,GO:0020037,GO:0042126,GO:0042802,GO:0046872,GO:0062213,GO:0070026","DNA binding|protein binding|cellular_component|nucleoplasm|cytosol|tyrosine metabolic process|heme binding|nitrate metabolic process|identical protein binding|metal ion binding|peroxynitrite isomerase activity|nitric oxide binding","WP5224","2q37 copy number variation syndrome"]
["THEM4",3.22326570380466,2.95561548174054,2.98984525882503,3.22363242939465,2.92312438997718,2.70547125808715,2.83219655205894,2.8684655464005,3.5419579026285,3.04062859889897,3.70606963133467,3.19845018776306,3.38547368562148,3.43606501369726,2.98222034571104,3.29163617198104,3.4916530312235,3.31431657129524,3.30547785475884,3.04648598935432,2.8234904075056,3.2526992596943,3.62342198918037,3.7583604683864,2.96579844410183,3.29867652192614,3.40216357689991,3.75667075151581,117145,"thioesterase superfamily member 4","protein_coding","hsa00062,hsa04151","Fatty acid elongation|PI3K-Akt signaling pathway","GO:0005515,GO:0005739,GO:0005743,GO:0005758,GO:0005759,GO:0005829,GO:0005886,GO:0006631,GO:0016290,GO:0032587,GO:0043491,GO:0102991,GO:1902108","protein binding|mitochondrion|mitochondrial inner membrane|mitochondrial intermembrane space|mitochondrial matrix|cytosol|plasma membrane|fatty acid metabolic process|palmitoyl-CoA hydrolase activity|ruffle membrane|phosphatidylinositol 3-kinase/protein kinase B signal transduction|myristoyl-CoA hydrolase activity|regulation of mitochondrial membrane permeability involved in apoptotic process","WP4172","PI3K-Akt signaling pathway","R-HSA-109704,R-HSA-112399,R-HSA-1257604,R-HSA-1280218,R-HSA-1430728,R-HSA-162582,R-HSA-165158,R-HSA-168256,R-HSA-194138,R-HSA-199418,R-HSA-2404192,R-HSA-2428924,R-HSA-2428928,R-HSA-388841,R-HSA-389356,R-HSA-389357,R-HSA-4420097,R-HSA-5218920,R-HSA-556833,R-HSA-74751,R-HSA-74752,R-HSA-77289,R-HSA-8978868,R-HSA-9006925,R-HSA-9006934","PI3K Cascade|IRS-mediated signalling|PIP3 activates AKT signaling|Adaptive Immune System|Metabolism|Signal Transduction|Activation of AKT2|Immune System|Signaling by VEGF|Negative regulation of the PI3K/AKT network|Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)|IGF1R signaling cascade|IRS-related events triggered by IGF1R|Costimulation by the CD28 family|CD28 co-stimulation|CD28 dependent PI3K/Akt signaling|VEGFA-VEGFR2 Pathway|VEGFR2 mediated vascular permeability|Metabolism of lipids|Insulin receptor signalling cascade|Signaling by Insulin receptor|Mitochondrial Fatty Acid Beta-Oxidation|Fatty acid metabolism|Intracellular signaling by second messengers|Signaling by Receptor Tyrosine Kinases"]
["THSD4-AS2",0,0.0119868317251391,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.0118475742204128,101929173,"THSD4 antisense RNA 2","non_coding"]
["TIMM10",14.9192661478168,9.15930852935762,10.1475840818948,11.8582608511038,9.07354282573402,9.75006483840022,10.5427914421479,11.5946272221551,10.0978523303536,10.8202498033349,9.93392557735913,12.0772180407749,9.06418032504906,8.07206329642789,7.98069489302729,7.99676316815349,15.9185009361785,13.7588128833208,16.4223312775328,13.2128065957737,14.3134340446686,12.7491710382747,16.7172036625515,17.1036650494861,15.2296881019084,15.7165161140445,18.7951705907675,16.1197043964543,26519,"translocase of inner mitochondrial membrane 10","protein_coding",null,null,"GO:0005515,GO:0005739,GO:0005743,GO:0005744,GO:0005758,GO:0006626,GO:0007605,GO:0008270,GO:0032977,GO:0042719,GO:0042721,GO:0042803,GO:0045039,GO:0051087","protein binding|mitochondrion|mitochondrial inner membrane|TIM23 mitochondrial import inner membrane translocase complex|mitochondrial intermembrane space|protein targeting to mitochondrion|sensory perception of sound|zinc ion binding|membrane insertase activity|mitochondrial intermembrane space protein transporter complex|TIM22 mitochondrial import inner membrane insertion complex|protein homodimerization activity|protein insertion into mitochondrial inner membrane|protein-folding chaperone binding",null,null,"R-HSA-1268020,R-HSA-1268020,R-HSA-9609507,R-HSA-9609507","Mitochondrial protein import|Mitochondrial protein import|Protein localization|Protein localization"]
["TIMM22",9.1153009406416,9.33895867901448,9.32128936603258,10.5051492824562,7.85578705233979,8.20175074524631,9.43714237160479,9.90205886206319,7.78833084924407,8.48547515971806,9.18586694043729,9.23893411794739,7.71792789596088,8.43995170749314,8.41415153218107,7.54227308471745,9.08960188265351,9.86848536837376,9.0117689748281,8.8306374533006,8.17171865472701,9.48577877129455,7.82796002110881,8.68193682787575,8.48279946296353,9.44196912687093,7.73861485506817,9.87556001233632,29928,"translocase of inner mitochondrial membrane 22","protein_coding",null,null,"GO:0005515,GO:0005743,GO:0008320,GO:0030943,GO:0042721,GO:0045039,GO:0071806,GO:0140318","protein binding|mitochondrial inner membrane|protein transmembrane transporter activity|mitochondrion targeting sequence binding|TIM22 mitochondrial import inner membrane insertion complex|protein insertion into mitochondrial inner membrane|protein transmembrane transport|protein transporter activity",null,null,"R-HSA-1268020,R-HSA-1268020,R-HSA-9609507,R-HSA-9609507","Mitochondrial protein import|Mitochondrial protein import|Protein localization|Protein localization"]
["TJP3",0,0,0,0,0,0,0,0,0,0,0.0078002344664678,0,0,0,0,0,0,0,0,0,0,0,0,0,0.00822308237354149,0,0,0,27134,"tight junction protein 3","protein_coding","hsa04530","Tight junction","GO:0005515,GO:0005634,GO:0005654,GO:0005886,GO:0005923,GO:0030054,GO:0035633,GO:0045216,GO:0050839,GO:0090557,GO:0098609,GO:0150105,GO:1905605","protein binding|nucleus|nucleoplasm|plasma membrane|bicellular tight junction|cell junction|maintenance of blood-brain barrier|cell-cell junction organization|cell adhesion molecule binding|establishment of endothelial intestinal barrier|cell-cell adhesion|protein localization to cell-cell junction|positive regulation of blood-brain barrier permeability","WP5407,WP4905","15q11q13 copy number variation|1q21.1 copy number variation syndrome"]
["TLR3",1.07107821134216,1.51324035516637,1.21172874350842,0.846709579274914,1.3181187240126,1.08996413842306,1.33380213083099,1.00635051737134,1.09989839005693,0.595643568999737,0.577398902110521,0.843138145401979,1.07825200064066,0.824604164599018,0.99192897620886,1.11327510020822,1.47357185161147,0.858340610154283,1.03133229344794,1.49108848086353,1.50583383653155,1.30350791151427,1.49096412836777,1.46673104344488,1.48398269600653,1.15823853936957,1.28798922947602,1.03642933821045,7098,"toll like receptor 3","protein_coding","hsa04217,hsa04620,hsa05161,hsa05160,hsa05171,hsa05164,hsa05168,hsa05167,hsa05165","Necroptosis|Toll-like receptor signaling pathway|Hepatitis B|Hepatitis C|Coronavirus disease - COVID-19|Influenza A|Herpes simplex virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Human papillomavirus infection","GO:0000139,GO:0001774,GO:0002224,GO:0002730,GO:0003725,GO:0004888,GO:0005515,GO:0005615,GO:0005737,GO:0005765,GO:0005769,GO:0005789,GO:0005886,GO:0006972,GO:0007165,GO:0007250,GO:0007252,GO:0007254,GO:0008584,GO:0009597,GO:0009986,GO:0010008,GO:0010628,GO:0016020,GO:0031012,GO:0032722,GO:0032727,GO:0032728,GO:0032729,GO:0032735,GO:0032755,GO:0032757,GO:0032760,GO:0034138,GO:0034343,GO:0034346,GO:0035458,GO:0036020,GO:0038023,GO:0038187,GO:0042742,GO:0042802,GO:0043065,GO:0043123,GO:0043330,GO:0043331,GO:0045087,GO:0045671,GO:0045766,GO:0045944,GO:0046330,GO:0050729,GO:0051607,GO:0060907,GO:0071260,GO:0071346,GO:0071360,GO:0071466,GO:0090594,GO:0097191,GO:0097527,GO:0098586,GO:1900017,GO:1901224","Golgi membrane|microglial cell activation|toll-like receptor signaling pathway|regulation of dendritic cell cytokine production|double-stranded RNA binding|transmembrane signaling receptor activity|protein binding|extracellular space|cytoplasm|lysosomal membrane|early endosome|endoplasmic reticulum membrane|plasma membrane|hyperosmotic response|signal transduction|activation of NF-kappaB-inducing kinase activity|I-kappaB phosphorylation|JNK cascade|male gonad development|detection of virus|cell surface|endosome membrane|positive regulation of gene expression|membrane|extracellular matrix|positive regulation of chemokine production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of type II interferon production|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of tumor necrosis factor production|toll-like receptor 3 signaling pathway|type III interferon production|positive regulation of type III interferon production|cellular response to interferon-beta|endolysosome membrane|signaling receptor activity|pattern recognition receptor activity|defense response to bacterium|identical protein binding|positive regulation of apoptotic process|positive regulation of canonical NF-kappaB signal transduction|response to exogenous dsRNA|response to dsRNA|innate immune response|negative regulation of osteoclast differentiation|positive regulation of angiogenesis|positive regulation of transcription by RNA polymerase II|positive regulation of JNK cascade|positive regulation of inflammatory response|defense response to virus|positive regulation of macrophage cytokine production|cellular response to mechanical stimulus|cellular response to type II interferon|cellular response to exogenous dsRNA|cellular response to xenobiotic stimulus|inflammatory response to wounding|extrinsic apoptotic signaling pathway|necroptotic signaling pathway|cellular response to virus|positive regulation of cytokine production involved in inflammatory response|positive regulation of non-canonical NF-kappaB signal transduction","WP5187,WP4666,WP5413,WP3858,WP4912,WP4868,WP5055,WP4298,WP75,WP5038,WP4136","mRNA vaccine activation of dendritic cell and induction of IFN-1|Hepatitis B infection|IL-24 Signaling pathway|Toll-like receptor signaling related to MyD88|SARS coronavirus and innate immunity|Type I interferon induction and signaling during SARS-CoV-2 infection|Burn wound healing|Acute viral myocarditis|Toll-like receptor signaling pathway|Mitochondrial immune response to SARS-CoV-2|Fibrin complement receptor 3 signaling pathway","R-HSA-1606322,R-HSA-1643685,R-HSA-1679131,R-HSA-168164,R-HSA-168249,R-HSA-168256,R-HSA-168898,R-HSA-168927,R-HSA-1810476,R-HSA-1834949,R-HSA-5260271,R-HSA-5602358,R-HSA-5602410,R-HSA-5602415,R-HSA-5602566,R-HSA-5602571,R-HSA-9013957,R-HSA-9013973,R-HSA-9014325","ZBP1(DAI) mediated induction of type I IFNs|Disease|Trafficking and processing of endosomal TLR|Toll Like Receptor 3 (TLR3) Cascade|Innate Immune System|Immune System|Toll-like Receptor Cascades|TICAM1, RIP1-mediated IKK complex recruitment|RIP-mediated NFkB activation via ZBP1|Cytosolic sensors of pathogen-associated DNA |Diseases of Immune System|Diseases associated with the TLR signaling cascade|TLR3 deficiency - HSE|UNC93B1 deficiency - HSE|TICAM1 deficiency - HSE|TRAF3 deficiency - HSE|TLR3-mediated TICAM1-dependent programmed cell death|TICAM1-dependent activation of IRF3/IRF7|TICAM1,TRAF6-dependent induction of TAK1 complex"]
["TLX2",0.0248329942286901,0,0,0.107173290453175,0,0.0116597235453917,0,0.0243511567204402,0,0.0239173563744312,0.0467079908171724,0,0.01180797866205,0.0118376098740655,0.0230945457187614,0.0353181760669925,0.0238754197069908,0.0114885474760134,0.0114755914400843,0.023879933895821,0.117193321137379,0.01180233814085,0.012257816116863,0.0121305777326921,0,0.0235958111412063,0.0720912972683845,0.0116729439232902,3196,"T cell leukemia homeobox 2","protein_coding",null,null,"GO:0000785,GO:0000978,GO:0000981,GO:0001228,GO:0001707,GO:0005515,GO:0005575,GO:0005634,GO:0005737,GO:0006357,GO:0043565,GO:0045944,GO:0048484,GO:0048513,GO:0050774,GO:1990837","chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|mesoderm formation|protein binding|cellular_component|nucleus|cytoplasm|regulation of transcription by RNA polymerase II|sequence-specific DNA binding|positive regulation of transcription by RNA polymerase II|enteric nervous system development|animal organ development|negative regulation of dendrite morphogenesis|sequence-specific double-stranded DNA binding","WP2064,WP2029,WP2023","Neural crest differentiation|Cell differentiation - index|Cell differentiation - expanded index"]
["TMC1",0.0146793693421182,0,0.00459383911692682,0.00469278985042345,0.00478135393363311,0,0,0.00479818127065489,0,0,0.00460169940388824,0.00492288840389805,0.00930663339092778,0,0.0227528856214517,0.00927884797500341,0.00470444147611882,0,0,0.00470533095732687,0,0,0.00483058972403515,0.00478044731488012,0,0,0,0,117531,"transmembrane channel like 1","protein_coding",null,null,"GO:0005245,GO:0008381,GO:0009897,GO:0032426,GO:0050910,GO:0060005,GO:0060117,GO:0070588,GO:1903169","voltage-gated calcium channel activity|mechanosensitive monoatomic ion channel activity|external side of plasma membrane|stereocilium tip|detection of mechanical stimulus involved in sensory perception of sound|vestibular reflex|auditory receptor cell development|calcium ion transmembrane transport|regulation of calcium ion transmembrane transport",null,null,"R-HSA-9659379,R-HSA-9662360,R-HSA-9662361,R-HSA-9709957","Sensory processing of sound|Sensory processing of sound by inner hair cells of the cochlea|Sensory processing of sound by outer hair cells of the cochlea|Sensory Perception"]
["TMEM11",22.200891253243,22.6690382065568,20.6844895003156,23.8016439772826,19.2192011434749,21.5083439364039,20.2931908773539,21.1355076773997,19.2177543130953,25.3660790839254,23.3660990189415,21.9396127017042,17.9820477722429,20.0927858313263,20.4896955143541,19.5824662551209,24.1312704989657,23.7179863420223,31.0248603931031,24.6499371296507,26.0003903429306,28.1637667403821,25.8339232509707,24.6036100319611,22.6242060188538,27.297631844101,28.1544108187598,26.2149098185238,8834,"transmembrane protein 11","protein_coding",null,null,"GO:0003674,GO:0005515,GO:0005739,GO:0005743,GO:0005886,GO:0007005,GO:0007007","molecular_function|protein binding|mitochondrion|mitochondrial inner membrane|plasma membrane|mitochondrion organization|inner mitochondrial membrane organization",null,null,"R-HSA-1592230,R-HSA-1852241,R-HSA-8949613","Mitochondrial biogenesis|Organelle biogenesis and maintenance|Cristae formation"]
["TMEM126A",39.2445557772643,30.5718694589797,36.5107620107893,35.7303763781237,28.2145049815189,28.0813765032308,45.0643890907845,38.7268733194757,31.8298285882387,18.9500775373156,30.7615965965148,31.8367473852611,31.4781731243602,27.0199761886744,33.3924766809886,29.0943596173055,46.5067696195261,36.0815770149234,53.6674403713462,38.4897498167204,46.0247509037998,43.1098982668432,63.6367188449579,52.2198996150201,47.4641948333139,47.7506626959129,69.8006651595927,48.4468850916717,84233,"transmembrane protein 126A","protein_coding",null,null,"GO:0003674,GO:0005739,GO:0005743,GO:0005886,GO:0021554,GO:0032981,GO:0034142","molecular_function|mitochondrion|mitochondrial inner membrane|plasma membrane|optic nerve development|mitochondrial respiratory chain complex I assembly|toll-like receptor 4 signaling pathway"]
["TMEM151B",0,0,0,0,0,0,0,0,0,0.0105731176316208,0.00516203665567508,0,0,0.00523303828886099,0.0255234467295006,0.00520435486604498,0,0,0,0.0105565743204698,0,0,0,0,0,0,0,0,441151,"transmembrane protein 151B","protein_coding",null,null,"GO:0016020","membrane"]
["TMEM164",2.6621283683477,2.71704600550897,2.72881063550959,2.37775793490044,2.32106190119643,2.8143919976535,2.54839443997859,2.66521358436828,2.66031462715817,2.76048631268771,2.7859770596012,2.79839172762585,2.57559384441316,2.73804491192529,2.78008839785719,2.85991898263204,1.94135173724961,2.23520093515307,2.10814825653109,2.3915163789729,2.11295524364537,2.28161428887606,1.98390705630226,2.06674501565155,2.1469326569738,2.107002816969,2.15885138987002,2.26202881832539,84187,"transmembrane protein 164","protein_coding",null,null,"GO:0016020,GO:0160020","membrane|positive regulation of ferroptosis"]
["TMEM199",9.34983584895356,8.16115387148966,8.86828568162292,8.56440086015198,7.95684159045369,7.76974165701652,8.29081890603504,8.73958827119356,8.58648775625235,6.63798987392041,8.67782411645083,8.90513774291994,7.21975522847812,8.13843744702078,7.89815854177863,8.01090032373261,7.1813497568188,7.76897180649195,7.89763085952154,8.10788065773292,6.90964140358216,7.67356088377481,7.83154735310404,8.13477644818501,6.893701843815,7.69561073077215,8.09973326280376,7.49076142295549,147007,"transmembrane protein 199","protein_coding",null,null,"GO:0005515,GO:0005764,GO:0005783,GO:0005789,GO:0006879,GO:0007042,GO:0012505,GO:0016471,GO:0030663,GO:0033116,GO:0036295,GO:0070072,GO:1905146","protein binding|lysosome|endoplasmic reticulum|endoplasmic reticulum membrane|intracellular iron ion homeostasis|lysosomal lumen acidification|endomembrane system|vacuolar proton-transporting V-type ATPase complex|COPI-coated vesicle membrane|endoplasmic reticulum-Golgi intermediate compartment membrane|cellular response to increased oxygen levels|vacuolar proton-transporting V-type ATPase complex assembly|lysosomal protein catabolic process"]
["TMEM220",2.49196358580145,2.53270054394428,2.66019285392471,2.15943646781085,2.25581294449565,2.38165583919174,2.7616508021841,2.48082408447093,1.7240673096485,1.48025259354766,1.71305008461141,1.762621596464,1.74429499902394,1.88735996585045,1.64696298117323,1.48122264818049,1.95196681311879,1.8141500086419,1.82964061992971,2.09222287093062,1.98192549185431,1.76149758292096,2.43514085593307,2.09472763100696,2.05046475656528,2.15747485330052,2.40530701952438,2.04543281852822,388335,"transmembrane protein 220","protein_coding",null,null,"GO:0005515,GO:0016020","protein binding|membrane"]
["TMEM232",0.0340113528120353,0.0337569802754808,0.0402609211234487,0.0212731740243426,0.0520191583484477,0.058322283850782,0.0455289306936943,0.046401984740864,0.040160516623484,0.012818070826705,0.0083440985296024,0.0327304969430926,0.0815643785818209,0.0380649063573482,0.0495084018650369,0.05888752226563,0.0483389168427183,0.03420598575131,0.0656014280974442,0.0511920597279552,0.0334973986754183,0.0196785487658673,0.0627738168828523,0.0520092947104221,0.0615750037845419,0.0463677299245555,0.0515146874879574,0.0361452077839727,642987,"transmembrane protein 232","protein_coding",null,null,"GO:0016020","membrane"]
["TMEM256",17.9506635086708,17.2465244798694,30.8682916461021,25.3308904663104,17.6587514961772,19.2403477084717,32.5933751366812,26.3739133989166,21.7643920109249,15.6006587719983,28.1359354213678,24.4446575588876,22.5313177056541,28.0619566251623,25.9122615316745,25.6158929954588,34.0520764616054,33.8333859307337,45.1906475208213,26.7934732296956,24.7010675295841,35.3894432285467,35.1441757110739,33.1850720915092,28.8222724673514,33.1938570188442,47.7250853503904,38.7516089183627,254863,"transmembrane protein 256","protein_coding",null,null,"GO:0003674,GO:0008150,GO:0016020,GO:0070062","molecular_function|biological_process|membrane|extracellular exosome"]
["TMEM38B",7.15882396960245,5.24673894415696,3.38608916541807,3.69737810341467,5.82250746130836,4.61638266508293,3.12747867695137,3.940903699367,3.25591080729204,2.14844228620548,2.14344198741256,3.09805658787357,3.63169027556682,2.07468021635666,2.81865632760462,2.92541503357269,2.52931804630118,2.17615358428715,2.29695046025039,2.44818993983444,3.02085220822856,2.46606498143021,4.14704769985806,3.07948095659788,2.75844010135608,2.66672726245106,3.18510764030908,2.15979386475792,55151,"transmembrane protein 38B","protein_coding",null,null,"GO:0005267,GO:0005515,GO:0005634,GO:0007029,GO:0008654,GO:0010881,GO:0014808,GO:0030282,GO:0031965,GO:0033017,GO:0042802,GO:0048286,GO:0051649,GO:0060348,GO:0060487,GO:0061033,GO:0070278,GO:0071313,GO:0071805","potassium channel activity|protein binding|nucleus|endoplasmic reticulum organization|phospholipid biosynthetic process|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|bone mineralization|nuclear membrane|sarcoplasmic reticulum membrane|identical protein binding|lung alveolus development|establishment of localization in cell|bone development|lung epithelial cell differentiation|secretion by lung epithelial cell involved in lung growth|extracellular matrix constituent secretion|cellular response to caffeine|potassium ion transmembrane transport","WP4786","Type I collagen synthesis in the context of osteogenesis imperfecta"]
["TMEM65",6.05456040357861,6.0936447679836,5.70943907041498,5.0171967324202,6.51954537742873,5.68274000539777,6.08851438110602,5.45451226558647,4.03204437772875,2.24922254256478,2.85820164796688,3.60982421300514,4.54953918645697,3.27285551483983,4.21054861643861,3.69041333315188,5.40243318048376,4.43750294370919,4.63923829106441,5.68165797645421,5.02209817589757,4.64942651141935,7.41406372123135,5.57713176246837,5.68919385724219,4.25092713992799,5.58758869092843,4.03766587859557,157378,"transmembrane protein 65","protein_coding",null,null,"GO:0003231,GO:0005515,GO:0005739,GO:0005743,GO:0005886,GO:0014704,GO:1903779","cardiac ventricle development|protein binding|mitochondrion|mitochondrial inner membrane|plasma membrane|intercalated disc|regulation of cardiac conduction"]
["TMIGD3",0.0303049075157314,0.0144124975042566,0.0711283296659636,0.188917105518705,0.0592253599109271,0.199204967643977,0.155508127715074,0.118867591321136,0.182895773538065,0.102156285784775,0.0570000270174713,0.0457338823222164,0,0.0288920191530032,0,0,0.0582726657491592,0.0560801271960094,0.0840253255191336,0,0.0143016694878724,0.129626691924715,0.0747940381947995,0,0.0751124724958118,0.0719877824445741,0.0439882536171059,0.0427351791862783,57413,"transmembrane and immunoglobulin domain containing 3","protein_coding",null,null,"GO:0004888,GO:0005886,GO:0006954,GO:0007165,GO:0007190,GO:0008016,GO:0008285,GO:0009611,GO:0016020,GO:0030336,GO:0032088","transmembrane signaling receptor activity|plasma membrane|inflammatory response|signal transduction|activation of adenylate cyclase activity|regulation of heart contraction|negative regulation of cell population proliferation|response to wounding|membrane|negative regulation of cell migration|negative regulation of NF-kappaB transcription factor activity"]
["TMPPE",0.343988825507742,0.220109935782525,0.135051409046043,0.221936295494515,0.519475800402021,0.334769329366957,0.268421263940844,0.25145253026022,0.245349800151672,0.265044263377165,0.211746504078128,0.346081339197004,0.362817267330381,0.160994240832506,0.215210623428184,0.343943858778311,0.144316110024716,0.237263828164137,0.173411895705961,0.300715408862108,0.147579292453161,0.303194125590036,0.191406794079118,0.299405737500244,0.248028006626541,0.124797752405886,0.163409728228186,0.135235524111751,643853,"transmembrane protein with metallophosphoesterase domain","protein_coding",null,null,"GO:0005515,GO:0016020,GO:0016787,GO:0046872","protein binding|membrane|hydrolase activity|metal ion binding"]
["TNC",34.1416219586634,36.9640926616045,34.4690887731018,29.9067337649209,38.4417052914382,36.1481020872201,32.3845859565377,29.6658098517091,74.8020109527187,84.2903406972952,53.1570361537223,65.3790348090185,72.6578140210723,62.8913405670472,60.0872303385568,68.6651901960145,54.2821658964597,60.0272850706835,40.4682745484301,62.0100167601157,52.1795018245269,52.2440460817443,40.6404722772287,50.6616052684162,57.9938669029882,47.2320581992433,36.1351125817403,48.0784178401869,3371,"tenascin C","protein_coding","hsa04151,hsa04512,hsa04510,hsa05206,hsa05165","PI3K-Akt signaling pathway|ECM-receptor interaction|Focal adhesion|MicroRNAs in cancer|Human papillomavirus infection","GO:0001558,GO:0001649,GO:0002009,GO:0005201,GO:0005515,GO:0005576,GO:0005604,GO:0005614,GO:0005615,GO:0005788,GO:0005925,GO:0007155,GO:0007162,GO:0007528,GO:0008284,GO:0009611,GO:0009612,GO:0010628,GO:0014012,GO:0016020,GO:0030155,GO:0030334,GO:0042475,GO:0045471,GO:0045545,GO:0050727,GO:0060447,GO:0060739,GO:0060740,GO:0062023,GO:0071300,GO:0071305,GO:0071774,GO:0071799,GO:0090733,GO:0098966","regulation of cell growth|osteoblast differentiation|morphogenesis of an epithelium|extracellular matrix structural constituent|protein binding|extracellular region|basement membrane|interstitial matrix|extracellular space|endoplasmic reticulum lumen|focal adhesion|cell adhesion|negative regulation of cell adhesion|neuromuscular junction development|positive regulation of cell population proliferation|response to wounding|response to mechanical stimulus|positive regulation of gene expression|peripheral nervous system axon regeneration|membrane|regulation of cell adhesion|regulation of cell migration|odontogenesis of dentin-containing tooth|response to ethanol|syndecan binding|regulation of inflammatory response|bud outgrowth involved in lung branching|mesenchymal-epithelial cell signaling involved in prostate gland development|prostate gland epithelium morphogenesis|collagen-containing extracellular matrix|cellular response to retinoic acid|cellular response to vitamin D|response to fibroblast growth factor|cellular response to prostaglandin D stimulus|tenascin complex|perisynaptic extracellular matrix","WP306,WP3859,WP3678,WP5055,WP3932,WP5236,WP4172,WP5094","Focal adhesion|TGF-beta signaling in thyroid cells for epithelial-mesenchymal transition|Amplification and expansion of oncogenic pathways as metastatic traits|Burn wound healing|Focal adhesion: PI3K-Akt-mTOR-signaling pathway|Markers of kidney cell lineage|PI3K-Akt signaling pathway|Orexin receptor pathway","R-HSA-1474244,R-HSA-1474244,R-HSA-216083,R-HSA-3000170,R-HSA-3000171,R-HSA-3000178,R-HSA-381426,R-HSA-392499,R-HSA-597592,R-HSA-8957275","Extracellular matrix organization|Extracellular matrix organization|Integrin cell surface interactions|Syndecan interactions|Non-integrin membrane-ECM interactions|ECM proteoglycans|Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)|Metabolism of proteins|Post-translational protein modification|Post-translational protein phosphorylation"]
["TNFSF9",0.131976573979158,0.0627658092045839,0.0464641242873008,0.0316433038996117,0.0322404881522458,0.0774579553765158,0.0153916189610057,0.0323539542472923,0.0995629073207522,0.174776740384881,0,0.0165974248574506,0.0156885689567384,0.0157279382108912,0.0306843688833727,0.0469251898662427,0.0793046759239247,0.0152641594678244,0.0152469455424866,0.0317278681076056,0,0.0156810747269188,0,0.0322343748563948,0.016355579996334,0.0156751854307095,0,0.0310183124326353,8744,"TNF superfamily member 9","protein_coding","hsa04060","Cytokine-cytokine receptor interaction","GO:0005102,GO:0005125,GO:0005164,GO:0005615,GO:0005886,GO:0006955,GO:0007165,GO:0007267,GO:0032813,GO:0042104,GO:0042129,GO:0042981,GO:0045585","signaling receptor binding|cytokine activity|tumor necrosis factor receptor binding|extracellular space|plasma membrane|immune response|signal transduction|cell-cell signaling|tumor necrosis factor receptor superfamily binding|positive regulation of activated T cell proliferation|regulation of T cell proliferation|regulation of apoptotic process|positive regulation of cytotoxic T cell differentiation","WP3850,WP5078","Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling|T cell modulation in pancreatic cancer","R-HSA-1280215,R-HSA-168256,R-HSA-5668541,R-HSA-5669034","Cytokine Signaling in Immune system|Immune System|TNFR2 non-canonical NF-kB pathway|TNFs bind their physiological receptors"]
["TNNI3",0,0,0,0,0,0,0,0,0,0,0,0,0.0304093970051133,0,0,0.0303186082409809,0,0,0,0,0.120724412901186,0.0303948708229958,0,0,0,0,0,0.0300616385023286,7137,"troponin I3%2C cardiac type","protein_coding","hsa04024,hsa04814,hsa04260,hsa04261,hsa05410,hsa05414,hsa05415","cAMP signaling pathway|Motor proteins|Cardiac muscle contraction|Adrenergic signaling in cardiomyocytes|Hypertrophic cardiomyopathy|Dilated cardiomyopathy|Diabetic cardiomyopathy","GO:0001570,GO:0001980,GO:0003009,GO:0003779,GO:0005515,GO:0005829,GO:0005861,GO:0006874,GO:0006940,GO:0007507,GO:0010882,GO:0019855,GO:0019901,GO:0019904,GO:0030017,GO:0030172,GO:0031014,GO:0032780,GO:0048306,GO:0051015,GO:0055010,GO:0060047,GO:0060048,GO:0097512,GO:1990584","vasculogenesis|regulation of systemic arterial blood pressure by ischemic conditions|skeletal muscle contraction|actin binding|protein binding|cytosol|troponin complex|intracellular calcium ion homeostasis|regulation of smooth muscle contraction|heart development|regulation of cardiac muscle contraction by calcium ion signaling|calcium channel inhibitor activity|protein kinase binding|protein domain specific binding|sarcomere|troponin C binding|troponin T binding|negative regulation of ATP-dependent activity|calcium-dependent protein binding|actin filament binding|ventricular cardiac muscle tissue morphogenesis|heart contraction|cardiac muscle contraction|cardiac myofibril|cardiac Troponin complex","WP2406,WP383","Cardiac progenitor differentiation|Striated muscle contraction pathway","R-HSA-390522,R-HSA-397014,R-HSA-5576891,R-HSA-5578775","Striated Muscle Contraction|Muscle contraction|Cardiac conduction|Ion homeostasis"]
["TNRC17",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.012780974516504,0,0,0,27321,"trinucleotide repeat containing 17","non_coding"]
["TOMM70",23.3598616416631,19.15483138122,18.9065241576205,18.2103046287605,20.3207157338725,17.8983268803937,18.9483067624081,17.9487743527281,21.6319195499455,14.5958729863282,17.5167582418013,18.4152719834963,22.2025163582994,17.0243192720477,20.7462331655094,18.4832218793391,22.8320405727029,18.6514774938838,21.0792592141394,22.4190818519312,22.2282058555584,20.5732946667467,26.4299802223653,23.8239783199305,22.116581732594,20.7529820598378,24.5072079242252,19.3649669803979,9868,"translocase of outer mitochondrial membrane 70","protein_coding",null,null,"GO:0002218,GO:0002230,GO:0005515,GO:0005739,GO:0005741,GO:0005742,GO:0006626,GO:0008320,GO:0016020,GO:0030150,GO:0030943,GO:0031966,GO:0032728,GO:0042981,GO:0045039,GO:0045040,GO:0060090,GO:0061052,GO:0070062,GO:0097068,GO:0098586,GO:1903955","activation of innate immune response|positive regulation of defense response to virus by host|protein binding|mitochondrion|mitochondrial outer membrane|mitochondrial outer membrane translocase complex|protein targeting to mitochondrion|protein transmembrane transporter activity|membrane|protein import into mitochondrial matrix|mitochondrion targeting sequence binding|mitochondrial membrane|positive regulation of interferon-beta production|regulation of apoptotic process|protein insertion into mitochondrial inner membrane|protein insertion into mitochondrial outer membrane|molecular adaptor activity|negative regulation of cell growth involved in cardiac muscle cell development|extracellular exosome|response to thyroxine|cellular response to virus|positive regulation of protein targeting to mitochondrion","WP5116,WP5038,WP5183","SARS-CoV-2 B.1.1.7 variant antagonises innate immune activation|Mitochondrial immune response to SARS-CoV-2|SARS-CoV-2 mitochondrial chronic oxidative stress and endothelial dysfunction","R-HSA-1268020,R-HSA-1632852,R-HSA-1643685,R-HSA-168249,R-HSA-168256,R-HSA-168928,R-HSA-392499,R-HSA-5205647,R-HSA-5205685,R-HSA-5663205,R-HSA-5688426,R-HSA-5689880,R-HSA-597592,R-HSA-9609507,R-HSA-9612973,R-HSA-9663891,R-HSA-9678108,R-HSA-9679506,R-HSA-9692914,R-HSA-9692916,R-HSA-9694516,R-HSA-9705671,R-HSA-9705683,R-HSA-9824446","Mitochondrial protein import|Macroautophagy|Disease|Innate Immune System|Immune System|DDX58/IFIH1-mediated induction of interferon-alpha/beta|Metabolism of proteins|Mitophagy|PINK1-PRKN Mediated Mitophagy|Infectious disease|Deubiquitination|Ub-specific processing proteases|Post-translational protein modification|Protein localization|Autophagy|Selective autophagy|SARS-CoV-1 Infection|SARS-CoV Infections|SARS-CoV-1-host interactions|SARS-CoV-1 activates/modulates innate immune responses|SARS-CoV-2 Infection|SARS-CoV-2 activates/modulates innate and adaptive immune responses|SARS-CoV-2-host interactions|Viral Infection Pathways"]
["TP53TG1",19.9703791742787,23.5453114861511,31.188770751065,27.7095955445533,26.1178832247196,23.9941181082697,27.8065855282993,28.6669705315903,24.5938143478869,21.2451981551022,28.2428912037635,26.2798482328833,26.7182958306053,28.9571279285592,27.4348077837816,24.6586365095713,31.6841615546516,28.94635004793,34.8087337243545,26.2137433790564,30.6387082622266,32.6240563349606,30.247404314501,33.8652072214886,29.1340333952727,35.0649040985262,40.8543073903908,36.2639896303978,11257,"TP53 target 1","non_coding"]
["TPM4",489.76094694346,527.074970578065,557.875482288693,513.791630615212,488.196703858366,514.406516625018,574.377136472175,520.377678116056,564.943588054033,495.525763703021,538.26103524354,585.987842080553,578.864849172602,580.72053129684,615.462329166286,590.038842019663,542.918895938528,531.561457773919,522.917986927521,535.139885482153,529.741715412858,535.604913286155,537.426499096326,535.102675117669,544.906456953448,518.815668075378,527.815561080961,506.886920182995,7171,"tropomyosin 4","protein_coding","hsa04814,hsa04260,hsa04261,hsa05410,hsa05414","Motor proteins|Cardiac muscle contraction|Adrenergic signaling in cardiomyocytes|Hypertrophic cardiomyopathy|Dilated cardiomyopathy","GO:0001649,GO:0001725,GO:0002102,GO:0005509,GO:0005515,GO:0005829,GO:0005856,GO:0005862,GO:0005884,GO:0005925,GO:0006936,GO:0007015,GO:0008307,GO:0016020,GO:0030863,GO:0042802,GO:0042803,GO:0046982,GO:0051015,GO:0070062","osteoblast differentiation|stress fiber|podosome|calcium ion binding|protein binding|cytosol|cytoskeleton|muscle thin filament tropomyosin|actin filament|focal adhesion|muscle contraction|actin filament organization|structural constituent of muscle|membrane|cortical cytoskeleton|identical protein binding|protein homodimerization activity|protein heterodimerization activity|actin filament binding|extracellular exosome","WP383","Striated muscle contraction pathway","R-HSA-162582,R-HSA-1643685,R-HSA-194315,R-HSA-390522,R-HSA-397014,R-HSA-445355,R-HSA-5663202,R-HSA-9012999,R-HSA-9013424,R-HSA-9700206,R-HSA-9716542,R-HSA-9725370","Signal Transduction|Disease|Signaling by Rho GTPases|Striated Muscle Contraction|Muscle contraction|Smooth Muscle Contraction|Diseases of signal transduction by growth factor receptors and second messengers|RHO GTPase cycle|RHOV GTPase cycle|Signaling by ALK in cancer|Signaling by Rho GTPases, Miro GTPases and RHOBTB3|Signaling by ALK fusions and activated point mutants"]
["TPRG1",0.0231521404636734,0.0118577452048432,0.0167200447245969,0.0102481154674878,0.0121817753529792,0.00668955069160818,0,0.017463782122118,0.00358275613464828,0.00857633798376224,0.0150737881966294,0.0143341396496164,0.00846826165278494,0.00679160968197577,0.0115938098337743,0.0118201709322164,0.00684904019342986,0.00823917698547344,1.64597707560935E-3,0.00685033515959666,0.0134475000100026,3.38568658876657E-3,0,0.00695969457126707,0.0035313184082994,0.0253831127713195,0.0155103930731034,0.00334856781943222,285386,"tumor protein p63 regulated 1","protein_coding",null,null,"GO:0005515,GO:0005737","protein binding|cytoplasm"]
["TRAF3IP3",0.00781566112938333,0,0,0.0074956739014157,0,0,0,0.00766401293709418,0,0,0,0.00786320447001285,0,0,0,0,0.00751428474686535,0,0.0288936028024623,0.0150314109851631,0.00737682517220209,0,0.0308631125424293,0,0.0154972558503971,0,0.0529415021062935,0.029390503053016,80342,"TRAF3 interacting protein 3","protein_coding",null,null,"GO:0000139,GO:0005515,GO:0005739,GO:0005741,GO:0005765,GO:0005886,GO:0032481,GO:0060090","Golgi membrane|protein binding|mitochondrion|mitochondrial outer membrane|lysosomal membrane|plasma membrane|positive regulation of type I interferon production|molecular adaptor activity","WP2849","Hematopoietic stem cell differentiation"]
["TRAPPC2B",4.52893401129756,3.82529767428501,5.54451065901805,4.6909922091501,3.85902176266391,3.91266784806481,5.10434907624301,5.29374181772263,4.55549368733504,3.45465960228503,4.73623107557369,5.03035823381217,4.68598998365892,4.35232638523002,5.22273528702406,4.56894091044427,6.79270131441938,4.86093723482749,9.71091077253052,4.91257422364494,5.98449899638693,6.16464357873333,9.33556263993847,7.57499143970747,7.07638237857519,9.50169062672464,8.97549570578711,7.32328181499268,10597,"zinc finger protein 547","protein_coding",null,null,"GO:0001222,GO:0005515,GO:0005634,GO:0005640,GO:0005654,GO:0005737,GO:0005783,GO:0005793,GO:0006888,GO:0006901,GO:0010628,GO:0030008,GO:0043231,GO:0048208,GO:0048471,GO:0099022,GO:0140416,GO:1990071,GO:1990072","transcription corepressor binding|protein binding|nucleus|nuclear outer membrane|nucleoplasm|cytoplasm|endoplasmic reticulum|endoplasmic reticulum-Golgi intermediate compartment|endoplasmic reticulum to Golgi vesicle-mediated transport|vesicle coating|positive regulation of gene expression|TRAPP complex|intracellular membrane-bounded organelle|COPII vesicle coating|perinuclear region of cytoplasm|vesicle tethering|transcription regulator inhibitor activity|TRAPPII protein complex|TRAPPIII protein complex"]
["TRIM22",28.5336391877209,26.989297957971,22.5383609196418,20.383075842861,30.4082951479096,25.0590754213756,23.4082221840643,22.5707144768051,23.0208655619974,19.2110160893625,17.4944836211664,20.3683161076296,23.4603970179521,18.2423388590798,20.5379363253722,21.8239179080554,28.0076984816275,21.5216614728184,18.6678786397298,24.7279072063651,28.1296555991785,22.7039265753417,25.3769645245361,28.1410333861439,28.205628113678,20.2121203507006,22.7611795966961,19.9541620150522,10346,"tripartite motif containing 22","protein_coding",null,null,"GO:0000209,GO:0002230,GO:0003713,GO:0003714,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005794,GO:0005829,GO:0006355,GO:0006955,GO:0008270,GO:0009615,GO:0010508,GO:0015030,GO:0016567,GO:0016604,GO:0016607,GO:0019901,GO:0030674,GO:0032880,GO:0042802,GO:0042803,GO:0043123,GO:0045087,GO:0045892,GO:0045893,GO:0046596,GO:0051091,GO:0051092,GO:0051607,GO:0061630","protein polyubiquitination|positive regulation of defense response to virus by host|transcription coactivator activity|transcription corepressor activity|protein binding|nucleus|nucleoplasm|cytoplasm|Golgi apparatus|cytosol|regulation of DNA-templated transcription|immune response|zinc ion binding|response to virus|positive regulation of autophagy|Cajal body|protein ubiquitination|nuclear body|nuclear speck|protein kinase binding|protein-macromolecule adaptor activity|regulation of protein localization|identical protein binding|protein homodimerization activity|positive regulation of canonical NF-kappaB signal transduction|innate immune response|negative regulation of DNA-templated transcription|positive regulation of DNA-templated transcription|regulation of viral entry into host cell|positive regulation of DNA-binding transcription factor activity|positive regulation of NF-kappaB transcription factor activity|defense response to virus|ubiquitin protein ligase activity",null,null,"R-HSA-1280215,R-HSA-168256,R-HSA-877300,R-HSA-913531","Cytokine Signaling in Immune system|Immune System|Interferon gamma signaling|Interferon Signaling"]
["TRIM31",0,0,0,0,0,0,0,0,0,0.0126583570670136,0,0,0,0,0,0,0,0.0121607199270722,0.0242940117176237,0,0,0,0,0,0,0,0,0,11074,"tripartite motif containing 31","protein_coding",null,null,"GO:0003713,GO:0005515,GO:0005737,GO:0005739,GO:0005829,GO:0006511,GO:0006954,GO:0008270,GO:0016567,GO:0019076,GO:0032897,GO:0045087,GO:0045893,GO:0046597,GO:0051091,GO:0051607,GO:0061630,GO:0070534,GO:0070936,GO:0140374,GO:1900226","transcription coactivator activity|protein binding|cytoplasm|mitochondrion|cytosol|ubiquitin-dependent protein catabolic process|inflammatory response|zinc ion binding|protein ubiquitination|viral release from host cell|negative regulation of viral transcription|innate immune response|positive regulation of DNA-templated transcription|negative regulation of viral entry into host cell|positive regulation of DNA-binding transcription factor activity|defense response to virus|ubiquitin protein ligase activity|protein K63-linked ubiquitination|protein K48-linked ubiquitination|antiviral innate immune response|negative regulation of NLRP3 inflammasome complex assembly",null,null,"R-HSA-1280215,R-HSA-168256,R-HSA-877300,R-HSA-913531","Cytokine Signaling in Immune system|Immune System|Interferon gamma signaling|Interferon Signaling"]
["TRIM66",2.51407790990681,2.23744984316113,2.37323066020907,3.60929402479695,3.05694162115925,2.74543430763869,2.3263461793124,2.56316638122167,2.83864981936226,3.31137287636139,1.87561654494526,3.15608748239556,2.52341893541837,3.01043681150043,1.63713497308668,2.67088455187229,2.44195018855418,1.73548572370018,1.83531371879682,2.04361699848282,2.06432388088437,2.07567378076627,3.56748225077499,2.76720121852105,2.46351264468753,2.83192813183696,2.55438511087416,2.45573553711004,9866,"tripartite motif containing 66","protein_coding",null,null,"GO:0005634,GO:0008270","nucleus|zinc ion binding"]
["TRMO",1.12865626516207,1.13811316274837,1.26278368068038,1.53007552518959,1.0531216150445,1.14752381981883,1.25096334028043,1.17748939327415,1.28892147410034,1.04208783847528,1.33677086028125,1.16540413588246,1.24685228988996,1.16098574649821,1.52316762786056,1.07818373181731,1.14632643378478,1.09926935931356,1.22351878059562,0.75076136579256,1.01322139379632,1.06476299250737,1.20638674821917,1.3057890038041,1.00118907853523,1.08048981620225,1.49045608143626,1.02117772421069,51531,"tRNA methyltransferase O","protein_coding",null,null,"GO:0005515,GO:0030488,GO:0089715","protein binding|tRNA methylation|tRNA m6t6A37 methyltransferase activity"]
["TRMT5",4.34230049861722,4.13449744240148,4.57581016364078,4.82004502763185,4.40026560340535,4.08183655982518,5.21837612506113,4.75744682687455,4.56098987461443,3.16245996075027,4.39458022352623,4.45411178109391,4.70727789463773,4.24207047272952,4.64073873299771,4.68475255922182,4.55712478381618,4.38979417265355,5.07849123138887,4.88877336121542,4.39364636389126,4.26340199008959,5.83040971826254,4.66130215233617,4.42907154690253,4.44008329988288,5.46428297567268,4.43505321310589,57570,"tRNA methyltransferase 5","protein_coding",null,null,"GO:0002939,GO:0005634,GO:0005737,GO:0005759,GO:0009019,GO:0052906,GO:0070901","tRNA N1-guanine methylation|nucleus|cytoplasm|mitochondrial matrix|tRNA (guanine-N1-)-methyltransferase activity|tRNA (guanine(37)-N(1))-methyltransferase activity|mitochondrial tRNA methylation",null,null,"R-HSA-6782315,R-HSA-6782861,R-HSA-72306,R-HSA-8953854","tRNA modification in the nucleus and cytosol|Synthesis of wybutosine at G37 of tRNA(Phe)|tRNA processing|Metabolism of RNA"]
["TRPM7",8.8847969485375,8.19760563964306,6.25780994343751,4.99634906411447,9.76986897910774,7.62398801979321,5.94198460810253,6.06858870087432,8.31695642379369,5.08106547953008,4.18139685868307,5.73637486864726,9.49859890453265,6.21448900677951,7.3806271944742,8.47944833180654,4.88926609186459,4.0552453889438,4.26398879383455,5.78042470249112,5.661640439853,4.91579265860167,7.21881683014047,6.28156309683901,5.34098020554732,3.84632591062025,5.42906436597814,3.82704627570833,54822,"transient receptor potential cation channel subfamily M member 7","protein_coding","hsa04217,hsa04218,hsa04621,hsa04978","Necroptosis|Cellular senescence|NOD-like receptor signaling pathway|Mineral absorption","GO:0001726,GO:0003779,GO:0004674,GO:0005262,GO:0005524,GO:0005886,GO:0006816,GO:0016310,GO:0016340,GO:0017022,GO:0031032,GO:0046872,GO:0051262,GO:0070266,GO:0070588,GO:0098655,GO:0106310","ruffle|actin binding|protein serine/threonine kinase activity|calcium channel activity|ATP binding|plasma membrane|calcium ion transport|phosphorylation|calcium-dependent cell-matrix adhesion|myosin binding|actomyosin structure organization|metal ion binding|protein tetramerization|necroptotic process|calcium ion transmembrane transport|monoatomic cation transmembrane transport|protein serine kinase activity","WP4754","IL-18 signaling pathway","R-HSA-2672351,R-HSA-3295583,R-HSA-382551,R-HSA-983712","Stimuli-sensing channels|TRP channels|Transport of small molecules|Ion channel transport"]
["TSEN54",3.82703107366642,4.24903789999137,4.07636934686978,4.31098766617059,3.86200102477506,3.33241159181547,4.34962225248578,3.83465346114126,3.49952225439057,4.91902971420306,5.26123197234909,5.19441988256819,2.83217141895532,4.11297357839177,4.03798057090719,3.82653079848869,4.81674574759829,4.35223188477218,5.15762370448408,4.53662650216147,4.85998343159641,5.18542459095709,5.09703028961398,4.74500981204359,3.79420747101327,5.58017179317239,4.74028503201869,6.05747447713236,283989,"tRNA splicing endonuclease subunit 54","protein_coding",null,null,"GO:0000214,GO:0000379,GO:0005515,GO:0005654,GO:0005730,GO:0006388,GO:0006397","tRNA-intron endonuclease complex|tRNA-type intron splice site recognition and cleavage|protein binding|nucleoplasm|nucleolus|tRNA splicing, via endonucleolytic cleavage and ligation|mRNA processing",null,null,"R-HSA-6784531,R-HSA-72306,R-HSA-8953854","tRNA processing in the nucleus|tRNA processing|Metabolism of RNA"]
["TSPAN31",10.1739128417743,8.34911960999971,12.0319662295666,10.3341651594698,9.36783562828561,9.80930838594135,12.0038193816635,11.6193662486487,12.2572472570478,8.44033024743712,12.0323537111894,12.4832119819893,11.4319705957095,12.2729383701992,12.4246999784374,12.0088021130684,13.2027519788414,12.4012599362114,13.7570213134511,12.1312030400467,11.3191161438776,12.8352574586293,12.8428932379555,12.9753846740999,13.3589597178662,12.844042935526,14.33464439924,12.9368524666252,6302,"tetraspanin 31","protein_coding",null,null,"GO:0005515,GO:0005886,GO:0008284,GO:0016020","protein binding|plasma membrane|positive regulation of cell population proliferation|membrane"]
["TST",13.5833140083922,9.9846357710083,11.7867353480446,14.5743074899295,11.4911195547732,13.1286464619194,12.9566728508901,13.5948621922657,13.1691301987252,14.9063627129424,16.3801541213661,13.9717208819966,13.5846134810188,15.4241284625539,11.6974775413798,13.2780515711543,17.9147130696227,19.165906332521,18.9930393976027,18.4801485659125,18.9330536654272,20.2005155059332,16.9179443823566,17.0621047185454,18.3575143360761,21.9034409816709,20.0445277310669,21.6055055646887,7263,"thiosulfate sulfurtransferase","protein_coding","hsa00920,hsa00270,hsa04122","Sulfur metabolism|Cysteine and methionine metabolism|Sulfur relay system","GO:0000098,GO:0004792,GO:0005615,GO:0005739,GO:0005759,GO:0008097,GO:0009440,GO:0030855,GO:0035928,GO:0051029","sulfur amino acid catabolic process|thiosulfate sulfurtransferase activity|extracellular space|mitochondrion|mitochondrial matrix|5S rRNA binding|cyanate catabolic process|epithelial cell differentiation|rRNA import into mitochondrion|rRNA transport","WP5030","Ethylmalonic encephalopathy","R-HSA-1430728,R-HSA-1430728,R-HSA-1614517,R-HSA-1614558,R-HSA-1614558,R-HSA-1614635,R-HSA-1614635,R-HSA-71291,R-HSA-71291","Metabolism|Metabolism|Sulfide oxidation to sulfate|Degradation of cysteine and homocysteine|Degradation of cysteine and homocysteine|Sulfur amino acid metabolism|Sulfur amino acid metabolism|Metabolism of amino acids and derivatives|Metabolism of amino acids and derivatives"]
["TTBK1",0,0,0.00198023941276603,0,0,0,0,0,0,0,0.00198362770078406,0,0.00200587806536076,0,0,0.00199988941683465,0,0,0.00194941385105032,0,0.00199081925030712,0,0,0,0,0,0,0,84630,"tau tubulin kinase 1","protein_coding",null,null,"GO:0004674,GO:0004713,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005875,GO:0006468,GO:0007165,GO:0007611,GO:0010628,GO:0010629,GO:0018105,GO:0018107,GO:0018108,GO:0021762,GO:0032091,GO:0032273,GO:0043025,GO:0048156,GO:0048471,GO:0050321,GO:0061890,GO:0106310,GO:1903980,GO:1904031,GO:2001056","protein serine/threonine kinase activity|protein tyrosine kinase activity|ATP binding|nucleus|nucleoplasm|cytoplasm|cytosol|microtubule associated complex|protein phosphorylation|signal transduction|learning or memory|positive regulation of gene expression|negative regulation of gene expression|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|peptidyl-tyrosine phosphorylation|substantia nigra development|negative regulation of protein binding|positive regulation of protein polymerization|neuronal cell body|tau protein binding|perinuclear region of cytoplasm|tau-protein kinase activity|positive regulation of astrocyte activation|protein serine kinase activity|positive regulation of microglial cell activation|positive regulation of cyclin-dependent protein kinase activity|positive regulation of cysteine-type endopeptidase activity","WP4223","Ras signaling"]
["TTC39A",0.353425933084298,0.324771218760918,0.247450717019243,0.183840563811433,0.380473582961114,0.399386988224493,0.184432639470078,0.293702006889309,0.228965186717042,0.184620731338276,0.0732355347129477,0.144641025157729,0.227867748224982,0.228439564769745,0.111418352789846,0.181749950201933,0.0921485087713372,0.0387981013317725,0.0775086947177608,0.063364077929567,0.0735010467213389,0.0170819174025236,0.0118274305732043,0.0468186386803103,0.0593889282533552,0.0227673359944706,0.011593348619975,0.0450523755688232,22996,"tetratricopeptide repeat domain 39A","protein_coding",null,null,"GO:0003674,GO:0005813,GO:0008150","molecular_function|centrosome|biological_process"]
["TTLL3",0.740017212755967,0.967833827661196,0.761165017072533,0.767123365974862,0.861355988878148,0.730681500572767,0.467055166566426,0.843044517150984,0.788142707608119,1.17915125706502,0.532192016484884,0.908750889792964,0.652003498403135,1.01677279030538,0.617366528881972,0.866742546128518,0.575463159086242,0.488360667608244,0.206187700781862,0.512782294691875,0.616293985117279,0.434461363083968,0.537176398661882,0.786768605194961,0.609593662027273,0.392936460946152,0.458094063859529,0.439929081175176,26140,"tubulin tyrosine ligase like 3","protein_coding",null,null,"GO:0003341,GO:0005524,GO:0005829,GO:0005874,GO:0005929,GO:0005930,GO:0015630,GO:0018094,GO:0030317,GO:0035082,GO:0036126,GO:0046872,GO:0060271,GO:0070735,GO:0070736","cilium movement|ATP binding|cytosol|microtubule|cilium|axoneme|microtubule cytoskeleton|protein polyglycylation|flagellated sperm motility|axoneme assembly|sperm flagellum|metal ion binding|cilium assembly|protein-glycine ligase activity|protein-glycine ligase activity, initiating",null,null,"R-HSA-392499,R-HSA-597592,R-HSA-8955332","Metabolism of proteins|Post-translational protein modification|Carboxyterminal post-translational modifications of tubulin"]
["TUBA3D",0,0,0,0,0,0,0,0.0173902504079196,0.107030125369808,0.034160908347954,0,0.0356844634435188,0.0168652116284937,0,0,0,0,0,0,0,0,0,0,0.0173259764853122,0,0,0.0171612068387788,0,113457,"tubulin alpha 3d","protein_coding","hsa04145,hsa04210,hsa04530,hsa04540,hsa04814,hsa05130,hsa05132,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022","Phagosome|Apoptosis|Tight junction|Gap junction|Motor proteins|Pathogenic Escherichia coli infection|Salmonella infection|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases","GO:0000226,GO:0000278,GO:0005200,GO:0005525,GO:0005737,GO:0005874,GO:0015630,GO:0016787,GO:0046872","microtubule cytoskeleton organization|mitotic cell cycle|structural constituent of cytoskeleton|GTP binding|cytoplasm|microtubule|microtubule cytoskeleton|hydrolase activity|metal ion binding","WP5124,WP2059,WP5223,WP2272,WP2359","Alzheimer's disease|Alzheimer's disease and miRNA effects|2q21.1 copy number variation syndrome|Pathogenic Escherichia coli infection|Parkin-ubiquitin proteasomal system pathway","R-HSA-109582,R-HSA-112314,R-HSA-112315,R-HSA-112316,R-HSA-1266738,R-HSA-1266738,R-HSA-1280218,R-HSA-1445148,R-HSA-157858,R-HSA-157858,R-HSA-162582,R-HSA-1632852,R-HSA-1632852,R-HSA-1640170,R-HSA-1643685,R-HSA-168256,R-HSA-1852241,R-HSA-190828,R-HSA-190828,R-HSA-190840,R-HSA-190861,R-HSA-190861,R-HSA-190872,R-HSA-194315,R-HSA-195258,R-HSA-199977,R-HSA-199991,R-HSA-199991,R-HSA-2132295,R-HSA-2262752,R-HSA-2467813,R-HSA-2500257,R-HSA-2555396,R-HSA-2995410,R-HSA-3371497,R-HSA-373760,R-HSA-373760,R-HSA-380320,R-HSA-389957,R-HSA-389958,R-HSA-389960,R-HSA-389977,R-HSA-390466,R-HSA-391251,R-HSA-392499,R-HSA-392499,R-HSA-422475,R-HSA-422475,R-HSA-437239,R-HSA-437239,R-HSA-438064,R-HSA-442755,R-HSA-446203,R-HSA-453274,R-HSA-5358351,R-HSA-5610787,R-HSA-5617833,R-HSA-5620924,R-HSA-5626467,R-HSA-5653656,R-HSA-5653656,R-HSA-5663205,R-HSA-5663220,R-HSA-597592,R-HSA-597592,R-HSA-6807878,R-HSA-6811434,R-HSA-6811436,R-HSA-6811442,R-HSA-68877,R-HSA-68882,R-HSA-68886,R-HSA-69275,R-HSA-69278,R-HSA-8852276,R-HSA-8856688,R-HSA-8953897,R-HSA-8955332,R-HSA-8955332,R-HSA-948021,R-HSA-9609646,R-HSA-9609690,R-HSA-9609736,R-HSA-9612973,R-HSA-9612973,R-HSA-9619483,R-HSA-9646399,R-HSA-9646399,R-HSA-9648025,R-HSA-9663891,R-HSA-9663891,R-HSA-9668328,R-HSA-9675108,R-HSA-9675108,R-HSA-9716542,R-HSA-9824446,R-HSA-983189,R-HSA-983231","Hemostasis|Neurotransmitter receptors and postsynaptic signal transmission|Transmission across Chemical Synapses|Neuronal System|Developmental Biology|Developmental Biology|Adaptive Immune System|Translocation of SLC2A4 (GLUT4) to the plasma membrane|Gap junction trafficking and regulation|Gap junction trafficking and regulation|Signal Transduction|Macroautophagy|Macroautophagy|Cell Cycle|Disease|Immune System|Organelle biogenesis and maintenance|Gap junction trafficking|Gap junction trafficking|Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane|Gap junction assembly|Gap junction assembly|Transport of connexons to the plasma membrane|Signaling by Rho GTPases|RHO GTPase Effectors|ER to Golgi Anterograde Transport|Membrane Trafficking|Membrane Trafficking|MHC class II antigen presentation|Cellular responses to stress|Separation of Sister Chromatids|Resolution of Sister Chromatid Cohesion|Mitotic Metaphase and Anaphase|Nuclear Envelope (NE) Reassembly|HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand|L1CAM interactions|L1CAM interactions|Recruitment of NuMA to mitotic centrosomes|Prefoldin mediated transfer of substrate  to CCT/TriC|Cooperation of Prefoldin and TriC/CCT  in actin and tubulin folding|Formation of tubulin folding intermediates by CCT/TriC|Post-chaperonin tubulin folding pathway|Chaperonin-mediated protein folding|Protein folding|Metabolism of proteins|Metabolism of proteins|Axon guidance|Axon guidance|Recycling pathway of L1|Recycling pathway of L1|Post NMDA receptor activation events|Activation of NMDA receptors and postsynaptic events|Asparagine N-linked glycosylation|Mitotic G2-G2/M phases|Signaling by Hedgehog|Hedgehog 'off' state|Cilium Assembly|Intraflagellar transport|RHO GTPases activate IQGAPs|Vesicle-mediated transport|Vesicle-mediated transport|Infectious disease|RHO GTPases Activate Formins|Post-translational protein modification|Post-translational protein modification|COPI-mediated anterograde transport|COPI-dependent Golgi-to-ER retrograde traffic|COPI-independent Golgi-to-ER retrograde traffic|Intra-Golgi and retrograde Golgi-to-ER traffic|Mitotic Prometaphase|Mitotic Anaphase|M Phase|G2/M Transition|Cell Cycle, Mitotic|The role of GTSE1 in G2/M progression after G2 checkpoint|Golgi-to-ER retrograde transport|Cellular responses to stimuli|Carboxyterminal post-translational modifications of tubulin|Carboxyterminal post-translational modifications of tubulin|Transport to the Golgi and subsequent modification|HCMV Infection|HCMV Early Events|Assembly and cell surface presentation of NMDA receptors|Autophagy|Autophagy|Activation of AMPK downstream of NMDARs|Aggrephagy|Aggrephagy|EML4 and NUDC in mitotic spindle formation|Selective autophagy|Selective autophagy|Sealing of the nuclear envelope (NE) by ESCRT-III|Nervous system development|Nervous system development|Signaling by Rho GTPases, Miro GTPases and RHOBTB3|Viral Infection Pathways|Kinesins|Factors involved in megakaryocyte development and platelet production"]
["TVP23C",0.758277052972369,0.883781884400281,1.25835427565028,0.916721809071101,0.881842496165816,0.787278484801133,0.807108690952837,0.848291454129581,1.0850016407008,0.84860893558507,0.853730099588641,0.848849122483706,0.919167397629004,1.04874938857742,0.725058020829331,0.91642317774041,0.87792538504784,0.958533576597165,0.567562111111065,0.816470929235794,0.730821543729027,0.649708427354306,0.484999629289479,0.808637095867583,1.06413006349365,0.882865693525678,0.723435977672767,0.712868165324832,201158,"trans-golgi network vesicle protein 23 homolog C","protein_coding",null,null,"GO:0009306,GO:0016020,GO:0016192","protein secretion|membrane|vesicle-mediated transport"]
["TXK",0.180219362170188,0.145888097070114,0.104397771146421,0.0625169058124761,0.0899248210084262,0.136828431443488,0.0858602744203134,0.101521461840828,0.104137419278732,0.0886337081460429,0.108182483709901,0.150453413437539,0.0729306448799731,0.171817097968709,0.139074828695719,0.119976296252609,0.158523617063066,0.0816013714252887,0.0992287699089399,0.0663712700413154,0.0868597553988905,0.105698919916042,0.238483397404226,0.108638555259255,0.0760313448478232,0.0692250080912958,0.0556579681257691,0.147798067077665,7294,"TXK tyrosine kinase","protein_coding","hsa04670","Leukocyte transendothelial migration","GO:0001819,GO:0002250,GO:0004715,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0005886,GO:0006468,GO:0007202,GO:0007229,GO:0010468,GO:0010543,GO:0032729,GO:0042246,GO:0045944,GO:0046777,GO:0050852,GO:0060335","positive regulation of cytokine production|adaptive immune response|non-membrane spanning protein tyrosine kinase activity|protein binding|ATP binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|plasma membrane|protein phosphorylation|activation of phospholipase C activity|integrin-mediated signaling pathway|regulation of gene expression|regulation of platelet activation|positive regulation of type II interferon production|tissue regeneration|positive regulation of transcription by RNA polymerase II|protein autophosphorylation|T cell receptor signaling pathway|positive regulation of type II interferon-mediated signaling pathway","WP306","Focal adhesion","R-HSA-168249,R-HSA-168249,R-HSA-168256,R-HSA-168256,R-HSA-2454202,R-HSA-2454202,R-HSA-2871809,R-HSA-2871809","Innate Immune System|Innate Immune System|Immune System|Immune System|Fc epsilon receptor (FCERI) signaling|Fc epsilon receptor (FCERI) signaling|FCERI mediated Ca+2 mobilization|FCERI mediated Ca+2 mobilization"]
["TYW3",10.5722950646225,8.28799957222595,10.801874708404,8.73286137649869,9.29618877193099,8.40338360525131,9.71019041090781,8.50599294901421,8.34650210526193,6.48113037984692,7.8331420602309,8.53769216726053,8.97266551509997,7.12585884139549,10.5323895319817,8.96818609748593,10.2324859763633,9.91279474984021,12.0906991677025,10.4229693084343,10.4968594957333,9.8704358339866,15.4157498138818,12.6811831383332,10.5827026793038,10.1871739431179,14.30616521224,9.65899599862571,127253,"tRNA-yW synthesizing protein 3 homolog","protein_coding",null,null,"GO:0005515,GO:0005737,GO:0008175,GO:0030488,GO:0031591","protein binding|cytoplasm|tRNA methyltransferase activity|tRNA methylation|wybutosine biosynthetic process",null,null,"R-HSA-6782315,R-HSA-6782861,R-HSA-72306,R-HSA-8953854","tRNA modification in the nucleus and cytosol|Synthesis of wybutosine at G37 of tRNA(Phe)|tRNA processing|Metabolism of RNA"]
["UBA3",31.1033252714343,24.9501348607218,24.8297351138351,20.5576196776219,28.4661144401516,24.1545121991815,25.434755655608,24.8863592906915,30.9786297743327,20.0690097141109,22.7785988100532,27.9265027926645,36.0996711086015,24.7655870772674,31.0317727030428,32.3492825180972,34.4048459851926,27.4840591750556,36.5766524540313,35.1208633922965,37.545648489466,29.7220526017483,52.1685133801104,42.3555121992236,35.4651957582802,30.3273486368063,48.0461959619941,31.3934159041248,9039,"ubiquitin like modifier activating enzyme 3","protein_coding","hsa04120","Ubiquitin mediated proteolysis","GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0006508,GO:0007113,GO:0019781,GO:0019788,GO:0032991,GO:0036211,GO:0042802,GO:0043687,GO:0045116,GO:0046982,GO:0051726","protein binding|ATP binding|nucleus|cytoplasm|cytosol|proteolysis|endomitotic cell cycle|NEDD8 activating enzyme activity|NEDD8 transferase activity|protein-containing complex|protein modification process|identical protein binding|post-translational protein modification|protein neddylation|protein heterodimerization activity|regulation of cell cycle","WP4860","Hijack of ubiquitination by SARS-CoV-2","R-HSA-1280215,R-HSA-1280218,R-HSA-168249,R-HSA-168256,R-HSA-392499,R-HSA-5607761,R-HSA-5607764,R-HSA-5621481,R-HSA-5668541,R-HSA-5676590,R-HSA-597592,R-HSA-8951664,R-HSA-983168,R-HSA-983169","Cytokine Signaling in Immune system|Adaptive Immune System|Innate Immune System|Immune System|Metabolism of proteins|Dectin-1 mediated noncanonical NF-kB signaling|CLEC7A (Dectin-1) signaling|C-type lectin receptors (CLRs)|TNFR2 non-canonical NF-kB pathway|NIK-->noncanonical NF-kB signaling|Post-translational protein modification|Neddylation|Antigen processing: Ubiquitination & Proteasome degradation|Class I MHC mediated antigen processing & presentation"]
["UBE2D2",30.9724633086788,30.8278539329954,30.2965034736992,32.2610586015061,28.5169529974758,29.4305759876773,31.4741984403528,31.0766150815929,30.8189195523752,27.4318539488476,29.7133362211195,27.7024735073563,30.6387238240374,29.4030479166263,31.552524906435,28.792903677739,31.2704270829538,31.2378987625689,35.0766646138839,34.1349749679124,33.8683818208982,35.650306147004,34.3943912659455,32.8979373941022,30.2721248146331,36.3118271134973,34.2652468727336,33.816761573882,7322,"ubiquitin conjugating enzyme E2 D2","protein_coding","hsa04141,hsa04120,hsa03083,hsa05131","Protein processing in endoplasmic reticulum|Ubiquitin mediated proteolysis|Polycomb repressive complex|Shigellosis","GO:0000151,GO:0000209,GO:0004842,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005829,GO:0006511,GO:0016567,GO:0031625,GO:0032991,GO:0036211,GO:0051865,GO:0061630,GO:0061631,GO:0070062,GO:0070936","ubiquitin ligase complex|protein polyubiquitination|ubiquitin-protein transferase activity|protein binding|ATP binding|nucleus|nucleoplasm|cytosol|ubiquitin-dependent protein catabolic process|protein ubiquitination|ubiquitin protein ligase binding|protein-containing complex|protein modification process|protein autoubiquitination|ubiquitin protein ligase activity|ubiquitin conjugating enzyme activity|extracellular exosome|protein K48-linked ubiquitination","WP183,WP4352","Proteasome degradation|Ciliary landscape","R-HSA-1234174,R-HSA-1234176,R-HSA-1280215,R-HSA-1280218,R-HSA-162582,R-HSA-166016,R-HSA-166166,R-HSA-168164,R-HSA-168249,R-HSA-168249,R-HSA-168256,R-HSA-168256,R-HSA-168898,R-HSA-168927,R-HSA-168928,R-HSA-202403,R-HSA-202424,R-HSA-2262752,R-HSA-2454202,R-HSA-2871837,R-HSA-392499,R-HSA-5357905,R-HSA-5607764,R-HSA-5621481,R-HSA-597592,R-HSA-73887,R-HSA-75893,R-HSA-8852135,R-HSA-8866652,R-HSA-8866654,R-HSA-8951664,R-HSA-8953897,R-HSA-9033241,R-HSA-936440,R-HSA-937041,R-HSA-937061,R-HSA-9609507,R-HSA-9674555,R-HSA-9705462,R-HSA-983168,R-HSA-983169","Cellular response to hypoxia|Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha|Cytokine Signaling in Immune system|Adaptive Immune System|Signal Transduction|Toll Like Receptor 4 (TLR4) Cascade|MyD88-independent TLR4 cascade |Toll Like Receptor 3 (TLR3) Cascade|Innate Immune System|Innate Immune System|Immune System|Immune System|Toll-like Receptor Cascades|TICAM1, RIP1-mediated IKK complex recruitment|DDX58/IFIH1-mediated induction of interferon-alpha/beta|TCR signaling|Downstream TCR signaling|Cellular responses to stress|Fc epsilon receptor (FCERI) signaling|FCERI mediated NF-kB activation|Metabolism of proteins|Regulation of TNFR1 signaling|CLEC7A (Dectin-1) signaling|C-type lectin receptors (CLRs)|Post-translational protein modification|Death Receptor Signaling|TNF signaling|Protein ubiquitination|Synthesis of active ubiquitin: roles of E1 and E2 enzymes|E3 ubiquitin ligases ubiquitinate target proteins|Neddylation|Cellular responses to stimuli|Peroxisomal protein import|Negative regulators of DDX58/IFIH1 signaling|IKK complex recruitment mediated by RIP1|TRIF(TICAM1)-mediated TLR4 signaling |Protein localization|Signaling by CSF3 (G-CSF)|Inactivation of CSF3 (G-CSF) signaling|Antigen processing: Ubiquitination & Proteasome degradation|Class I MHC mediated antigen processing & presentation"]
["UBE2V2",11.3446005176229,8.57523329403631,8.67878055185314,8.73296549669389,8.94482435494649,8.23994927735033,8.46752786704252,8.9231902427991,10.224614879043,6.38188918714758,9.15774345655747,9.6516156271526,11.4410824355762,7.79188535559228,10.7519083578011,8.95891520272843,13.36631710033,10.3408392746772,13.5163712681197,13.1836481937118,14.8202558784048,13.2891139069197,20.7296911938595,14.8346565711348,13.466926765019,13.1811895848764,18.2286576593378,11.5648512637317,7336,"ubiquitin conjugating enzyme E2 V2","protein_coding","hsa05131","Shigellosis","GO:0000209,GO:0000729,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006282,GO:0006301,GO:0016567,GO:0031372,GO:0042275,GO:0070062,GO:0070534,GO:1902523,GO:2000781","protein polyubiquitination|DNA double-strand break processing|protein binding|nucleus|nucleoplasm|cytoplasm|regulation of DNA repair|postreplication repair|protein ubiquitination|UBC13-MMS2 complex|error-free postreplication DNA repair|extracellular exosome|protein K63-linked ubiquitination|positive regulation of protein K63-linked ubiquitination|positive regulation of double-strand break repair",null,null,"R-HSA-1280218,R-HSA-1640170,R-HSA-168256,R-HSA-392499,R-HSA-5693532,R-HSA-5693538,R-HSA-5693565,R-HSA-5693567,R-HSA-5693571,R-HSA-5693606,R-HSA-5693607,R-HSA-5696395,R-HSA-5696398,R-HSA-5696399,R-HSA-597592,R-HSA-69473,R-HSA-69481,R-HSA-69620,R-HSA-73894,R-HSA-8852135,R-HSA-8866654,R-HSA-983168,R-HSA-983169","Adaptive Immune System|Cell Cycle|Immune System|Metabolism of proteins|DNA Double-Strand Break Repair|Homology Directed Repair|Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks|HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)|Nonhomologous End-Joining (NHEJ)|DNA Double Strand Break Response|Processing of DNA double-strand break ends|Formation of Incision Complex in GG-NER|Nucleotide Excision Repair|Global Genome Nucleotide Excision Repair (GG-NER)|Post-translational protein modification|G2/M DNA damage checkpoint|G2/M Checkpoints|Cell Cycle Checkpoints|DNA Repair|Protein ubiquitination|E3 ubiquitin ligases ubiquitinate target proteins|Antigen processing: Ubiquitination & Proteasome degradation|Class I MHC mediated antigen processing & presentation"]
["UBQLN2",14.0055394574436,15.6788606689835,13.7812899330024,12.5118682871576,14.7101825378339,15.1211222009412,15.0235408389218,13.6216249022637,14.6373746812521,15.6740748637727,15.2152381171117,14.148275666286,17.4103690585973,14.358250579145,16.3168001442415,17.7801483948209,10.7222838287016,11.0302947209141,12.2923089041427,13.7307846638553,12.6493614026197,12.0262013961897,14.2845081763717,11.5846331034466,11.1007735059135,11.1582488289732,11.7081342498757,10.5621375537941,29978,"ubiquilin 2","protein_coding","hsa04141,hsa05014","Protein processing in endoplasmic reticulum|Amyotrophic lateral sclerosis","GO:0000045,GO:0005515,GO:0005634,GO:0005737,GO:0005776,GO:0005829,GO:0005886,GO:0016241,GO:0030433,GO:0031410,GO:0031593,GO:0042802,GO:0140693,GO:1900186,GO:1903071,GO:1904021,GO:2000785","autophagosome assembly|protein binding|nucleus|cytoplasm|autophagosome|cytosol|plasma membrane|regulation of macroautophagy|ubiquitin-dependent ERAD pathway|cytoplasmic vesicle|polyubiquitin modification-dependent protein binding|identical protein binding|molecular condensate scaffold activity|negative regulation of clathrin-dependent endocytosis|positive regulation of ER-associated ubiquitin-dependent protein catabolic process|negative regulation of G protein-coupled receptor internalization|regulation of autophagosome assembly",null,null,"R-HSA-199991,R-HSA-5653656,R-HSA-8856825,R-HSA-8856828","Membrane Trafficking|Vesicle-mediated transport|Cargo recognition for clathrin-mediated endocytosis|Clathrin-mediated endocytosis"]
["UCN2",0.557838900061773,0.667525693820313,0.473036629815885,0.69032254435201,0.545096691209566,0.574533266875529,0.352568767041357,0.599952030094316,0.181003327283165,0.242638227518178,0.135384576854581,0.452606679190159,0.171128983146265,0.257337627202233,0.184085729742904,0.102370841443846,0.173009132789977,0.51614868737195,0.282730075620289,0.155737659676384,0.305719666449032,0.530246434724532,0.408591142966169,0.281286881256871,0.285447452219064,0.427457493220618,0.19154564642482,0.507515913033305,90226,"urocortin 2","protein_coding","hsa04080","Neuroactive ligand-receptor interaction","GO:0005179,GO:0005576,GO:0005615,GO:0007189,GO:0007586,GO:0009755,GO:0031669,GO:0042562,GO:0051429,GO:0051431","hormone activity|extracellular region|extracellular space|adenylate cyclase-activating G protein-coupled receptor signaling pathway|digestion|hormone-mediated signaling pathway|cellular response to nutrient levels|hormone binding|corticotropin-releasing hormone receptor binding|corticotropin-releasing hormone receptor 2 binding",null,null,"R-HSA-162582,R-HSA-372790,R-HSA-373080,R-HSA-500792","Signal Transduction|Signaling by GPCR|Class B/2 (Secretin family receptors)|GPCR ligand binding"]
["UHRF1",12.6815291532231,11.0115910305276,6.54623612681871,9.49353975356026,9.09670200396663,8.13854216339993,4.76639262761164,6.46769313043479,10.5337660555712,13.9733997677352,8.2355016872375,11.4710505693574,8.26222597730655,3.84782954842656,3.44231347050191,3.56994444517871,14.1888688982461,15.7924389159469,10.6996551725379,14.2732590113749,14.8164957793424,15.587754414596,10.0816263263616,13.2248127212002,15.7001581605944,13.4525083690732,10.5295972173443,13.1452687137313,29128,"ubiquitin like with PHD and ring finger domains 1","protein_coding",null,null,"GO:0000122,GO:0000724,GO:0000785,GO:0000791,GO:0000792,GO:0000987,GO:0003676,GO:0004842,GO:0005515,GO:0005634,GO:0005654,GO:0005657,GO:0006511,GO:0006974,GO:0007049,GO:0008270,GO:0008327,GO:0010390,GO:0016363,GO:0031507,GO:0035064,GO:0035825,GO:0040029,GO:0042393,GO:0042802,GO:0044027,GO:0044729,GO:0045944,GO:0050678,GO:0051247,GO:0051865,GO:0061630,GO:0062072,GO:0140612,GO:0141055,GO:2000373","negative regulation of transcription by RNA polymerase II|double-strand break repair via homologous recombination|chromatin|euchromatin|heterochromatin|cis-regulatory region sequence-specific DNA binding|nucleic acid binding|ubiquitin-protein transferase activity|protein binding|nucleus|nucleoplasm|replication fork|ubiquitin-dependent protein catabolic process|DNA damage response|cell cycle|zinc ion binding|methyl-CpG binding|histone monoubiquitination|nuclear matrix|heterochromatin formation|methylated histone binding|homologous recombination|epigenetic regulation of gene expression|histone binding|identical protein binding|negative regulation of gene expression via CpG island methylation|hemi-methylated DNA-binding|positive regulation of transcription by RNA polymerase II|regulation of epithelial cell proliferation|positive regulation of protein metabolic process|protein autoubiquitination|ubiquitin protein ligase activity|H3K9me3 modified histone binding|DNA damage sensor activity|histone H3 ubiquitin ligase activity|positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity","WP3651,WP5087","Pathways affected in adenoid cystic carcinoma|Pleural mesothelioma","R-HSA-212165,R-HSA-5334118,R-HSA-74160","Epigenetic regulation of gene expression|DNA methylation|Gene expression (Transcription)"]
["ULBP3",8.53483510341191,7.12904390773473,7.63860644607706,7.55383946350316,7.21378590645062,7.72986076058923,6.96048490329349,7.33263737547176,6.06607255069259,5.24920624450529,6.24194268861189,6.76479240130173,6.27899798025929,5.40258469236065,6.6883244562854,5.50442080378927,6.91447043275764,7.19948236587651,6.96713366900936,7.02409718084838,5.90472766109413,7.23963616047168,6.57808156518378,6.92459856084147,6.37414437280466,6.96522405423896,6.64912641439744,6.41898600799771,79465,"UL16 binding protein 3","protein_coding","hsa04650","Natural killer cell mediated cytotoxicity","GO:0001916,GO:0002476,GO:0002486,GO:0005515,GO:0005615,GO:0005886,GO:0006955,GO:0009897,GO:0030101,GO:0042267,GO:0046703","positive regulation of T cell mediated cytotoxicity|antigen processing and presentation of endogenous peptide antigen via MHC class Ib|antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent|protein binding|extracellular space|plasma membrane|immune response|external side of plasma membrane|natural killer cell activation|natural killer cell mediated cytotoxicity|natural killer cell lectin-like receptor binding",null,null,"R-HSA-1280218,R-HSA-168256,R-HSA-198933","Adaptive Immune System|Immune System|Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"]
["UPF3A",9.08414579356178,9.66936761256482,10.4415393147821,9.80555704519959,9.67484120508974,9.13738716006566,9.30454374948948,8.64821843462776,9.18256460215701,8.04891518837108,9.09183173201928,9.24777783226245,8.80540393209552,9.40943936554701,9.56684058170562,8.64293867523399,8.75543164477912,9.48911747642717,10.4573686697307,9.39153348297642,9.90425616121323,10.0639967913469,11.599979985258,9.83524661837564,9.87392845610853,8.79789226209907,10.844876937092,9.42623067751789,65110,"UPF3A regulator of nonsense mediated mRNA decay","protein_coding","hsa03013,hsa03015","Nucleocytoplasmic transport|mRNA surveillance pathway","GO:0000184,GO:0001701,GO:0003729,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0007283,GO:0035145,GO:0042162,GO:0043005,GO:0043231,GO:0045727,GO:0051028,GO:2000623","nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|in utero embryonic development|mRNA binding|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|spermatogenesis|exon-exon junction complex|telomeric DNA binding|neuron projection|intracellular membrane-bounded organelle|positive regulation of translation|mRNA transport|negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay",null,null,"R-HSA-1266738,R-HSA-376176,R-HSA-422475,R-HSA-8953854,R-HSA-9010553,R-HSA-927802,R-HSA-9675108,R-HSA-975957","Developmental Biology|Signaling by ROBO receptors|Axon guidance|Metabolism of RNA|Regulation of expression of SLITs and ROBOs|Nonsense-Mediated Decay (NMD)|Nervous system development|Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"]
["UQCRHL",9.37607486443238,6.87444799436727,11.0949370402649,9.83522038053692,8.68472308932979,11.8311975231842,11.3903556984979,13.5996798842223,9.43106032244111,10.7235547074881,9.91986339757318,11.3000800904476,10.5884198224108,10.9874464576752,11.262942184191,11.7606540466944,16.9961413936264,15.2722339869632,24.1913783202949,13.2425913854776,19.2663696882439,16.8034078796564,21.0194010730315,20.0378684569263,17.9135082503327,16.8898987132893,29.9599851565115,19.4655644441382,440567,"ubiquinol-cytochrome c reductase hinge protein like","protein_coding","hsa00190,hsa04260,hsa04714,hsa05208,hsa05010,hsa05012,hsa05014,hsa05016,hsa05020,hsa05022,hsa05415,hsa04932","Oxidative phosphorylation|Cardiac muscle contraction|Thermogenesis|Chemical carcinogenesis - reactive oxygen species|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis|Huntington disease|Prion disease|Pathways of neurodegeneration - multiple diseases|Diabetic cardiomyopathy|Non-alcoholic fatty liver disease","GO:0005750,GO:0006122","mitochondrial respiratory chain complex III|mitochondrial electron transport, ubiquinol to cytochrome c","WP4396","Nonalcoholic fatty liver disease"]
["USF3",0.962482846514207,1.10176133119536,0.881612325445795,0.707959976721212,1.25290653107394,1.0169944797335,0.940154187787794,0.853530422405593,1.16680382575283,0.685169734003301,0.766630719187898,0.887502564480761,1.38968338441046,0.866542592701926,1.22201108802202,1.30935382925957,0.700061731246478,0.738770531799107,0.657491389218817,0.893351085157236,0.78994877107939,0.785997317142947,0.940267510639891,0.953402094027837,0.838060975259251,0.596433797358873,0.720804787987456,0.582248240515482,205717,"upstream transcription factor family member 3","protein_coding",null,null,"GO:0000977,GO:0001228,GO:0005634,GO:0010719,GO:0045944,GO:0046983","RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|nucleus|negative regulation of epithelial to mesenchymal transition|positive regulation of transcription by RNA polymerase II|protein dimerization activity"]
["USP19",10.5376903828442,11.1872985682473,12.3933835080363,10.3309437976798,10.007326291817,12.0954100651153,10.9021583459206,10.6848560895825,11.1765926825807,14.1507836517346,13.1025399990569,11.4628268984193,11.2398050339424,11.4457824677001,11.8498101794274,11.5689097869313,10.057802161256,11.1923271591301,11.6083341940659,11.3332586415834,10.5462078457303,10.3664030494385,9.60532950284838,9.81391493887448,10.0491375583009,10.321623058153,10.1138498026511,10.3156795115072,10869,"ubiquitin specific peptidase 19","protein_coding",null,null,"GO:0004843,GO:0005515,GO:0005789,GO:0005829,GO:0016579,GO:0030433,GO:0031647,GO:0034976,GO:0046872,GO:0048642,GO:0050821,GO:0051879,GO:0090068,GO:1900037,GO:1904292","cysteine-type deubiquitinase activity|protein binding|endoplasmic reticulum membrane|cytosol|protein deubiquitination|ubiquitin-dependent ERAD pathway|regulation of protein stability|response to endoplasmic reticulum stress|metal ion binding|negative regulation of skeletal muscle tissue development|protein stabilization|Hsp90 protein binding|positive regulation of cell cycle process|regulation of cellular response to hypoxia|regulation of ERAD pathway","WP5216","Warburg effect modulated by deubiquitinating enzymes and their substrates","R-HSA-392499,R-HSA-5688426,R-HSA-5689880,R-HSA-597592","Metabolism of proteins|Deubiquitination|Ub-specific processing proteases|Post-translational protein modification"]
["USP46",5.58639531843885,5.19066019878491,4.72600050402055,4.18326525663151,6.63010973544386,5.2003988165427,4.92567965895375,4.82849901293751,6.34714429197729,4.59000098981859,4.36034322102232,5.13603064880468,6.59698025133546,4.98402394548878,6.15385076897535,6.5558403019171,4.46701576365907,4.12554937878302,4.25228776691676,5.11411553751433,4.53777933455117,4.52385191188732,5.846731456495,4.82959258231357,5.0291595122852,3.97875774660651,4.8430682341805,3.9305403172908,64854,"ubiquitin specific peptidase 46","protein_coding",null,null,"GO:0001662,GO:0004843,GO:0005515,GO:0005634,GO:0005829,GO:0008343,GO:0016579,GO:0032228,GO:0046872,GO:0048149,GO:0060013","behavioral fear response|cysteine-type deubiquitinase activity|protein binding|nucleus|cytosol|adult feeding behavior|protein deubiquitination|regulation of synaptic transmission, GABAergic|metal ion binding|behavioral response to ethanol|righting reflex"]
["UTS2",0,0,0,0.0151895295452307,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.0150545688036342,0.0156355574557636,0.015473257495696,0,0,0,0,10911,"urotensin 2","protein_coding","hsa04080","Neuroactive ligand-receptor interaction","GO:0005102,GO:0005179,GO:0005576,GO:0005615,GO:0006936,GO:0007165,GO:0007268,GO:0008217,GO:0045202,GO:0097746","signaling receptor binding|hormone activity|extracellular region|extracellular space|muscle contraction|signal transduction|chemical synaptic transmission|regulation of blood pressure|synapse|blood vessel diameter maintenance","WP3591,WP5158,WP3594","Sleep regulation|Urotensin-II-mediated signaling pathway|Circadian rhythm genes","R-HSA-162582,R-HSA-372790,R-HSA-373076,R-HSA-375276,R-HSA-388396,R-HSA-416476,R-HSA-500792","Signal Transduction|Signaling by GPCR|Class A/1 (Rhodopsin-like receptors)|Peptide ligand-binding receptors|GPCR downstream signalling|G alpha (q) signalling events|GPCR ligand binding"]
["UXT",47.6703055971246,39.2392270505379,57.0318173207646,56.7887187937888,44.1279690457935,50.069824398787,62.8910311823466,56.2175277352421,48.7917064838063,41.1097585790437,61.9175144712114,52.9071796421062,50.7064696527165,52.662264478614,54.192128318451,47.5462454623509,58.4049288695433,65.2741666002201,78.5113945200604,54.526044714882,57.8302344414634,64.6041209913038,71.5383591785468,68.8197648130694,56.8036275603081,66.7004893615498,86.9951082408345,73.6326584531203,8409,"ubiquitously expressed prefoldin like chaperone","protein_coding",null,null,"GO:0000122,GO:0000226,GO:0000922,GO:0003682,GO:0003714,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005813,GO:0005856,GO:0006915,GO:0007098,GO:0008017,GO:0047497,GO:0048487,GO:0050821,GO:0051015,GO:0101031,GO:1990062","negative regulation of transcription by RNA polymerase II|microtubule cytoskeleton organization|spindle pole|chromatin binding|transcription corepressor activity|protein binding|nucleus|nucleoplasm|cytoplasm|centrosome|cytoskeleton|apoptotic process|centrosome cycle|microtubule binding|mitochondrion transport along microtubule|beta-tubulin binding|protein stabilization|actin filament binding|protein folding chaperone complex|RPAP3/R2TP/prefoldin-like complex",null,null,"R-HSA-212436,R-HSA-73857,R-HSA-74160,R-HSA-8953750","Generic Transcription Pathway|RNA Polymerase II Transcription|Gene expression (Transcription)|Transcriptional Regulation by E2F6"]
["VAX2",0.21628719994494,0.324828966132675,0.293899975344857,0.305689282097769,0.200223234276574,0.374140242228288,0.223035478474642,0.184183902124418,0.498087830057133,0.493371226984809,0.374694539932733,0.309225164637249,0.297705171482703,0.265893813512082,0.206439198845208,0.31840300212873,0.20247475071827,0.226454892848032,0.305106318190992,0.284612911461891,0.182654303345323,0.378716496466423,0.202285024583941,0.26135298988824,0.174931492638155,0.254185576585226,0.181758052160714,0.347809856785282,25806,"ventral anterior homeobox 2","protein_coding",null,null,"GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001162,GO:0001227,GO:0003700,GO:0005515,GO:0005634,GO:0005737,GO:0006357,GO:0007398,GO:0007409,GO:0007417,GO:0007420,GO:0007601,GO:0009950,GO:0016055,GO:0030182,GO:0030900,GO:0031490,GO:0048048,GO:0060041,GO:1990837","negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|cytoplasm|regulation of transcription by RNA polymerase II|ectoderm development|axonogenesis|central nervous system development|brain development|visual perception|dorsal/ventral axis specification|Wnt signaling pathway|neuron differentiation|forebrain development|chromatin DNA binding|embryonic eye morphogenesis|retina development in camera-type eye|sequence-specific double-stranded DNA binding","WP2858","Ectoderm differentiation"]
["VIRMA",11.9703193173713,11.8498634988317,11.5685880297858,10.1837682498938,12.4120713254513,10.6886554064259,10.5972895082618,10.7183802128432,12.9054405569546,9.64148556856766,10.3509342830991,11.415428088997,13.0495700991083,11.17201654855,12.2965195434313,13.5035797339154,11.7471404333638,10.4873290861402,11.6213757192335,11.1993913837206,11.8795374702606,10.8269957186321,13.2150478915665,12.4761426164324,11.5663021768199,9.88808372252435,12.5626144875352,9.9976669115125,25962,"vir like m6A methyltransferase associated","protein_coding",null,null,"GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0008380,GO:0016604,GO:0016607,GO:0036396,GO:0080009,GO:0110104","RNA binding|protein binding|nucleus|nucleoplasm|cytosol|RNA splicing|nuclear body|nuclear speck|RNA N6-methyladenosine methyltransferase complex|mRNA methylation|mRNA alternative polyadenylation"]
["VPS16",11.5867926638932,12.1287393463637,14.5602002234281,11.8284142301819,11.565298861683,12.852929190708,12.7328361444278,13.3044406148861,12.1854140272087,15.0040562736545,15.099992293885,12.7288642200522,12.2969065938805,13.3621961076542,13.7010012847189,13.0530005433176,13.1019407377636,13.2997500766964,14.5451468814494,14.1669383312379,12.9468239608857,13.2466863165803,12.8538139501256,12.2924860050593,14.1224151952541,14.0078388787988,13.6301047521585,15.3754956964593,64601,"VPS16 core subunit of CORVET and HOPS complexes","protein_coding","hsa04140,hsa05132","Autophagy - animal|Salmonella infection","GO:0003779,GO:0005515,GO:0005764,GO:0005765,GO:0005768,GO:0005769,GO:0005770,GO:0005776,GO:0006886,GO:0008333,GO:0010008,GO:0016197,GO:0030136,GO:0030897,GO:0031902,GO:0033263,GO:0034058,GO:0035542,GO:0042144,GO:0055037,GO:0097352","actin binding|protein binding|lysosome|lysosomal membrane|endosome|early endosome|late endosome|autophagosome|intracellular protein transport|endosome to lysosome transport|endosome membrane|endosomal transport|clathrin-coated vesicle|HOPS complex|late endosome membrane|CORVET complex|endosomal vesicle fusion|regulation of SNARE complex assembly|vacuole fusion, non-autophagic|recycling endosome|autophagosome maturation","WP5115,WP4217","Network map of SARS-CoV-2 signaling pathway|Ebola virus infection in host","R-HSA-1643685,R-HSA-5663205,R-HSA-9679506,R-HSA-9694516,R-HSA-9705683,R-HSA-9754560,R-HSA-9824446","Disease|Infectious disease|SARS-CoV Infections|SARS-CoV-2 Infection|SARS-CoV-2-host interactions|SARS-CoV-2 modulates autophagy|Viral Infection Pathways"]
["VPS33B",6.65298671035853,6.01701063191357,6.51271153074419,6.80982691920044,5.70205767567718,6.11009719721785,6.19914653739554,5.52801191127866,5.99077091682522,5.66163611278926,6.92046664230441,6.29514040287773,5.54936542013428,6.49871175638068,6.42736618464417,5.86737671494209,6.00752670330377,6.26726308458641,6.14883220616062,6.0334917464282,5.41022293505876,5.9721262949436,5.51436957040918,4.95261820810036,5.75116920154618,5.89628205891283,5.60511754399654,6.37594682978316,26276,"VPS33B late endosome and lysosome associated","protein_coding",null,null,"GO:0005515,GO:0005737,GO:0005764,GO:0005765,GO:0005768,GO:0005770,GO:0005794,GO:0005829,GO:0006886,GO:0007032,GO:0008333,GO:0010008,GO:0015031,GO:0016192,GO:0017185,GO:0030136,GO:0030199,GO:0030897,GO:0031091,GO:0031901,GO:0031902,GO:0032400,GO:0032418,GO:0032963,GO:0033263,GO:0035855,GO:0043589,GO:0044877,GO:0046907,GO:0048471,GO:0055037,GO:0061025,GO:0070889,GO:0090330,GO:0090385,GO:0097352,GO:0099023","protein binding|cytoplasm|lysosome|lysosomal membrane|endosome|late endosome|Golgi apparatus|cytosol|intracellular protein transport|endosome organization|endosome to lysosome transport|endosome membrane|protein transport|vesicle-mediated transport|peptidyl-lysine hydroxylation|clathrin-coated vesicle|collagen fibril organization|HOPS complex|platelet alpha granule|early endosome membrane|late endosome membrane|melanosome localization|lysosome localization|collagen metabolic process|CORVET complex|megakaryocyte development|skin morphogenesis|protein-containing complex binding|intracellular transport|perinuclear region of cytoplasm|recycling endosome|membrane fusion|platelet alpha granule organization|regulation of platelet aggregation|phagosome-lysosome fusion|autophagosome maturation|vesicle tethering complex",null,null,"R-HSA-1643685,R-HSA-5663205,R-HSA-9635486,R-HSA-9636383,R-HSA-9637687,R-HSA-9637690,R-HSA-9679506,R-HSA-9694516,R-HSA-9705683,R-HSA-9754560,R-HSA-9824439,R-HSA-9824446","Disease|Infectious disease|Infection with Mycobacterium tuberculosis|Prevention of phagosomal-lysosomal fusion|Suppression of phagosomal maturation|Response of Mtb to phagocytosis|SARS-CoV Infections|SARS-CoV-2 Infection|SARS-CoV-2-host interactions|SARS-CoV-2 modulates autophagy|Bacterial Infection Pathways|Viral Infection Pathways"]
["VTI1B",22.1804252548256,19.2223952638233,19.1602373771331,20.8449618280211,20.4238601822003,20.4297993467013,20.7577204283179,21.5804146719017,21.5564472908693,18.6108522383556,20.9333596888414,20.5379285284495,22.0007374471306,20.4416092453673,20.5984192183679,20.9111191064268,22.5599871605439,20.6585822935513,23.7942907000494,21.3039614933449,22.8548605245847,23.4552465617499,24.6916589548239,24.4609632078284,22.1876897357269,24.0541421055933,26.4147752031257,23.8092210880598,10490,"vesicle transport through interaction with t-SNAREs 1B","protein_coding","hsa04130","SNARE interactions in vesicular transport","GO:0000149,GO:0005484,GO:0005515,GO:0005576,GO:0005765,GO:0005789,GO:0005794,GO:0005829,GO:0006886,GO:0006891,GO:0006896,GO:0006904,GO:0008021,GO:0012507,GO:0016192,GO:0016236,GO:0019869,GO:0031093,GO:0031201,GO:0031901,GO:0031902,GO:0031982,GO:0042147,GO:0043025,GO:0043231,GO:0048280,GO:0048471,GO:0055037,GO:0055038,GO:0061025,GO:0097352,GO:1903076","SNARE binding|SNAP receptor activity|protein binding|extracellular region|lysosomal membrane|endoplasmic reticulum membrane|Golgi apparatus|cytosol|intracellular protein transport|intra-Golgi vesicle-mediated transport|Golgi to vacuole transport|vesicle docking involved in exocytosis|synaptic vesicle|ER to Golgi transport vesicle membrane|vesicle-mediated transport|macroautophagy|chloride channel inhibitor activity|platelet alpha granule lumen|SNARE complex|early endosome membrane|late endosome membrane|vesicle|retrograde transport, endosome to Golgi|neuronal cell body|intracellular membrane-bounded organelle|vesicle fusion with Golgi apparatus|perinuclear region of cytoplasm|recycling endosome|recycling endosome membrane|membrane fusion|autophagosome maturation|regulation of protein localization to plasma membrane",null,null,"R-HSA-109582,R-HSA-114608,R-HSA-76002,R-HSA-76005","Hemostasis|Platelet degranulation |Platelet activation, signaling and aggregation|Response to elevated platelet cytosolic Ca2+"]
["VWC2L",0.0116240686654778,0,0,0,0.00567927529546892,0,0.00542257554598608,0.0170977882406454,0,0,0,0.0233895577551309,0,0.00554106318167235,0,0,0,0.00537767067063932,0,0.0111779509460602,0,0,0.00573775739321036,0.00567819841691992,0.00576218579431001,0,0,0,402117,"von Willebrand factor C domain containing 2 like","protein_coding",null,null,"GO:0005515,GO:0005615,GO:0030514,GO:0032281,GO:0045202,GO:0045666","protein binding|extracellular space|negative regulation of BMP signaling pathway|AMPA glutamate receptor complex|synapse|positive regulation of neuron differentiation"]
["WBP4",11.1461810615568,10.255933224029,7.90355983336625,10.3410317143931,9.35505100962081,8.73910160350376,9.33141330652184,8.96840056751283,10.1678619101318,7.35598226425943,9.02366409855963,10.8373149057912,9.7454153035506,8.64806923771178,9.02289696253491,7.90084883969342,11.3642971196794,9.42239603771618,11.3692600670184,10.6772585861835,10.8030384604165,10.6355271446665,13.3797808359373,12.927378582041,11.8247598218734,9.84890561546519,12.7526834819725,9.85520715568007,11193,"WW domain binding protein 4","protein_coding",null,null,"GO:0000398,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0008270,GO:0008380,GO:0016607,GO:0045292,GO:0070064,GO:0071005,GO:0071011","mRNA splicing, via spliceosome|RNA binding|protein binding|nucleus|nucleoplasm|zinc ion binding|RNA splicing|nuclear speck|mRNA cis splicing, via spliceosome|proline-rich region binding|U2-type precatalytic spliceosome|precatalytic spliceosome",null,null,"R-HSA-72163,R-HSA-72172,R-HSA-72203,R-HSA-8953854","mRNA Splicing - Major Pathway|mRNA Splicing|Processing of Capped Intron-Containing Pre-mRNA|Metabolism of RNA"]
["WDR31",1.04056905621621,1.05226458312365,1.14145795455572,0.987461378660049,1.21480875502384,1.19829125098975,1.2927521458183,0.972045041086316,0.953021866695276,0.965278165996231,0.772575030963643,0.809969170237694,1.04165468002074,1.0651540047675,1.15108151957816,1.0385447682709,0.816151778596197,1.06414946765324,0.890852821391806,1.01116625413072,0.816729350465289,0.942247170821854,0.973203856592389,1.03265917548378,0.78730751087595,1.00954308833669,0.95394274504061,0.875281067405265,114987,"WD repeat domain 31","protein_coding"]
["WDR44",6.38197484976974,4.85995872309178,3.77905226661679,3.82931990868964,5.02448439926416,4.15791021079598,3.71312427729763,3.82619016200451,4.6104755995845,3.04519156978438,3.13831687770579,3.59904284961656,4.63062168990436,3.13815550952657,4.29894511486836,4.0750925882975,4.56289919923099,3.74845405104656,4.14025077585066,4.98829791109997,4.39976808130736,3.63484441838382,5.37746437007861,4.69370384168574,4.91117257124025,3.38055458588418,4.98832305144156,3.81472201009499,54521,"WD repeat domain 44","protein_coding",null,null,"GO:0005515,GO:0005794,GO:0005829,GO:0010008,GO:0031267,GO:0048471,GO:0060627,GO:0061824,GO:0140313,GO:1902018","protein binding|Golgi apparatus|cytosol|endosome membrane|small GTPase binding|perinuclear region of cytoplasm|regulation of vesicle-mediated transport|cytosolic ciliogenesis|molecular sequestering activity|negative regulation of cilium assembly","WP2858","Ectoderm differentiation"]
["WDR86",0.0305181152590492,0.0248809636681926,0.057302997854132,0.0501748263677492,0.076682616653231,0.0409400935096965,0.01627035767898,0.106878459566706,0.0657794721664682,0.0839795903103512,0.065601195577604,0.127201289712947,0.0456067181673,0.0706599818247029,0.036490726896238,0.0372031830380595,0.0419161702926388,0.0322712425300665,0.0443229175449869,0.0419240954939572,0.0493792722346919,0.0497290171834749,0.0516481684419401,0.0596307261212104,0.10805845752066,0.0911356244320149,0.0421883137553676,0.0737757241847541,349136,"WD repeat domain 86","protein_coding"]
["WHRN",0.399227083135523,0.347821008531164,0.283468745807528,0.444014429553904,0.360603941536071,0.447353191539569,0.234753317196174,0.345424264480892,0.388070232620671,0.817480952973815,0.694109227569941,0.529915392418254,0.500897834850499,0.530940743257622,0.436798769493487,0.483497845123376,0.0709606593680957,0.273162914523636,0.182936780581078,0.280670209983882,0.151991059229421,0.124367413571578,0.139102948247393,0.163879802474639,0.123064798434146,0.133883836432948,0.123364195022758,0.148235492109615,25861,"whirlin","protein_coding",null,null,"GO:0001895,GO:0001917,GO:0002141,GO:0002142,GO:0005515,GO:0005737,GO:0005884,GO:0005886,GO:0005929,GO:0007605,GO:0010628,GO:0021694,GO:0030426,GO:0032391,GO:0032420,GO:0032426,GO:0036064,GO:0042802,GO:0043025,GO:0045184,GO:0045202,GO:0050910,GO:0050953,GO:0051649,GO:0060088,GO:0060113,GO:0060122,GO:1990075,GO:1990227,GO:1990696","retina homeostasis|photoreceptor inner segment|stereocilia ankle link|stereocilia ankle link complex|protein binding|cytoplasm|actin filament|plasma membrane|cilium|sensory perception of sound|positive regulation of gene expression|cerebellar Purkinje cell layer formation|growth cone|photoreceptor connecting cilium|stereocilium|stereocilium tip|ciliary basal body|identical protein binding|neuronal cell body|establishment of protein localization|synapse|detection of mechanical stimulus involved in sensory perception of sound|sensory perception of light stimulus|establishment of localization in cell|auditory receptor cell stereocilium organization|inner ear receptor cell differentiation|inner ear receptor cell stereocilium organization|periciliary membrane compartment|paranodal junction maintenance|USH2 complex","WP4352","Ciliary landscape","R-HSA-9659379,R-HSA-9662360,R-HSA-9662361,R-HSA-9709957","Sensory processing of sound|Sensory processing of sound by inner hair cells of the cochlea|Sensory processing of sound by outer hair cells of the cochlea|Sensory Perception"]
["WLS",55.3178060512338,54.4818131650554,57.0107368920489,51.7203883683048,58.383535529719,58.6119397413236,59.0782018921091,58.8148001189295,48.6380198587749,43.3291125453978,48.2299180740723,47.5701751554279,51.0135145915753,53.3367693678521,56.0824853089099,56.2514757510108,35.4666581900284,37.2104239261277,37.5280368512482,37.7104917398203,31.9326117674932,34.3701260019555,34.4188681018012,34.3641223156107,33.6837557579523,33.5273332266144,32.7080976198161,31.492705315239,79971,"Wnt ligand secretion mediator","protein_coding",null,null,"GO:0000139,GO:0001707,GO:0005515,GO:0005769,GO:0005783,GO:0005789,GO:0005794,GO:0005802,GO:0005829,GO:0005886,GO:0006886,GO:0009948,GO:0012505,GO:0016055,GO:0017147,GO:0030177,GO:0030666,GO:0030901,GO:0030902,GO:0031017,GO:0031410,GO:0031901,GO:0043123,GO:0061355,GO:0061357,GO:0070062,GO:0071529,GO:0090263","Golgi membrane|mesoderm formation|protein binding|early endosome|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|trans-Golgi network|cytosol|plasma membrane|intracellular protein transport|anterior/posterior axis specification|endomembrane system|Wnt signaling pathway|Wnt-protein binding|positive regulation of Wnt signaling pathway|endocytic vesicle membrane|midbrain development|hindbrain development|exocrine pancreas development|cytoplasmic vesicle|early endosome membrane|positive regulation of canonical NF-kappaB signal transduction|Wnt protein secretion|positive regulation of Wnt protein secretion|extracellular exosome|cementum mineralization|positive regulation of canonical Wnt signaling pathway",null,null,"R-HSA-162582,R-HSA-195721,R-HSA-3238698","Signal Transduction|Signaling by WNT|WNT ligand biogenesis and trafficking"]
["WTIP",2.63478861634659,2.59356558201444,2.93824363342571,2.93962642341883,2.30319113116346,2.61196251794779,2.50568319351826,2.69299655979487,2.74664832770607,3.90724839811182,3.85200607078924,3.28449320153088,2.35684632193734,3.04902419598251,2.59586732617372,2.55752783719001,2.55199581313117,3.09123541559293,2.85092545670846,2.71047993175239,2.79701364767951,2.80752796725317,2.3462185856975,2.41168138256914,2.75181772993106,3.05924203089478,2.4095674323172,3.35968095329693,126374,"WT1 interacting protein","protein_coding","hsa04390,hsa04392","Hippo signaling pathway|Hippo signaling pathway - multiple species","GO:0000932,GO:0001666,GO:0003714,GO:0005515,GO:0005634,GO:0005667,GO:0005912,GO:0006355,GO:0007010,GO:0022604,GO:0030030,GO:0035195,GO:0035278,GO:0035331,GO:0045892,GO:0046872,GO:2000637","P-body|response to hypoxia|transcription corepressor activity|protein binding|nucleus|transcription regulator complex|adherens junction|regulation of DNA-templated transcription|cytoskeleton organization|regulation of cell morphogenesis|cell projection organization|miRNA-mediated post-transcriptional gene silencing|miRNA-mediated gene silencing by inhibition of translation|negative regulation of hippo signaling|negative regulation of DNA-templated transcription|metal ion binding|positive regulation of miRNA-mediated gene silencing",null,null,"R-HSA-1234174,R-HSA-1234174,R-HSA-1234176,R-HSA-1234176,R-HSA-2262752,R-HSA-2262752,R-HSA-8953897,R-HSA-8953897","Cellular response to hypoxia|Cellular response to hypoxia|Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha|Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha|Cellular responses to stress|Cellular responses to stress|Cellular responses to stimuli|Cellular responses to stimuli"]
["XKR8",10.4269718762781,9.86623250441874,10.5829344925435,10.7381240057982,9.29913164627981,10.4835776483943,10.0923223045914,10.5435123341686,8.22041858221621,10.8567679767683,9.83654416785671,8.9528258183426,7.54519865956065,8.43214798788203,7.52981087460936,7.29658085664427,9.13912570029358,11.1219440919185,10.3480718994632,8.90112773634996,8.86964009103658,9.74637748057139,8.69936766225732,8.51376330646175,8.30656963929619,9.55733766716017,8.34888917506042,10.0369247441098,55113,"XK related 8","protein_coding",null,null,"GO:0002513,GO:0005886,GO:0017128,GO:0043652,GO:0045663,GO:0048471,GO:0051649,GO:0070782,GO:0097350,GO:1902742","tolerance induction to self antigen|plasma membrane|phospholipid scramblase activity|engulfment of apoptotic cell|positive regulation of myoblast differentiation|perinuclear region of cytoplasm|establishment of localization in cell|phosphatidylserine exposure on apoptotic cell surface|neutrophil clearance|apoptotic process involved in development"]
["XYLT2",11.8965436979154,12.6906135588846,11.4054775305078,11.466715978506,12.2922234495129,12.4293398757251,10.6229735649153,11.3535875430716,10.8657299231519,14.376658195657,12.6473174338227,10.3610476047027,10.9351293936011,11.3861528454883,9.76246784868971,11.4557798409106,10.5707260753835,11.6517018074384,11.2892210598404,11.108375419655,11.5227442816336,11.4530789374116,8.85747983332772,9.7114122760773,10.512497742854,11.6693098510404,9.43938145017523,11.4210265740891,64132,"xylosyltransferase 2","protein_coding","hsa00532,hsa00534","Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate|Glycosaminoglycan biosynthesis - heparan sulfate / heparin","GO:0000139,GO:0000287,GO:0005615,GO:0006024,GO:0015012,GO:0030145,GO:0030158,GO:0030203,GO:0030206,GO:0030210,GO:0050650","Golgi membrane|magnesium ion binding|extracellular space|glycosaminoglycan biosynthetic process|heparan sulfate proteoglycan biosynthetic process|manganese ion binding|protein xylosyltransferase activity|glycosaminoglycan metabolic process|chondroitin sulfate biosynthetic process|heparin biosynthetic process|chondroitin sulfate proteoglycan biosynthetic process","WP4784,WP5395","Proteoglycan biosynthesis|Glycosaminoglycan synthesis in fibroblasts","R-HSA-1430728,R-HSA-1630316,R-HSA-1638091,R-HSA-1793185,R-HSA-1971475,R-HSA-71387","Metabolism|Glycosaminoglycan metabolism|Heparan sulfate/heparin (HS-GAG) metabolism|Chondroitin sulfate/dermatan sulfate metabolism|A tetrasaccharide linker sequence is required for GAG synthesis|Metabolism of carbohydrates"]
["YJEFN3",0.748276793937012,1.09364216843911,0.822449604175487,1.1289718103899,1.04327556600711,0.702670042314732,0.97909245733331,0.850085361849557,0.688413128648058,1.50289493869333,1.18429423094475,1.08333875477819,0.564076814114823,0.896087832352547,0.704379735392819,0.778697632783758,0.631688321807575,0.928767780212177,0.708441014685018,0.54405667945926,0.63735869377131,0.572481321208476,0.594574624279227,0.445759720001262,0.732811927838456,0.580937017800685,0.370877266278821,0.754939942673239,374887,"YjeF N-terminal domain containing 3","protein_coding",null,null,"GO:0002040,GO:0005515,GO:0006869,GO:0008593,GO:0010874,GO:0016525,GO:0031580,GO:0052856,GO:0071425","sprouting angiogenesis|protein binding|lipid transport|regulation of Notch signaling pathway|regulation of cholesterol efflux|negative regulation of angiogenesis|membrane raft distribution|NADHX epimerase activity|hematopoietic stem cell proliferation"]
["YPEL3",9.31092256407835,10.121408178617,10.4486139028695,12.2238616611423,9.54245953518002,11.3522301990247,10.1479318406965,11.458230699754,9.55182030783152,13.6703377641269,16.4518686662368,13.0942589530284,9.81532141596838,11.7501550023663,10.3345567703261,10.0574076519066,10.149789877355,10.9518866389812,12.4645351168987,11.6412738709394,11.2513493900055,11.6511266730517,10.1393806756545,11.0375452447842,10.366168644847,13.4545570067261,9.46621173233126,14.3092648199541,83719,"yippee like 3","protein_coding",null,null,"GO:0005730,GO:0046872,GO:2000774","nucleolus|metal ion binding|positive regulation of cellular senescence","WP4949","16p11.2 proximal deletion syndrome"]
["YY1",16.7207744641016,16.9244872953922,14.8730708952212,14.156799615128,16.4275254351191,15.0508133439273,14.9960256151479,13.8598219779996,16.2254219237283,16.3784145699116,15.6977629502323,15.4154260627814,17.2705548844072,15.5793580587631,16.5707942733935,17.2111695266982,14.5052985785459,15.5054985841853,14.5576641298903,16.6185901857598,16.1168061230992,16.2897807369337,17.1913169591926,15.187037753737,14.8063305975995,14.9704642153724,15.0585781661659,13.7298045380194,7528,"YY1 transcription factor","protein_coding","hsa03082,hsa03083","ATP-dependent chromatin remodeling|Polycomb repressive complex","GO:0000122,GO:0000400,GO:0000723,GO:0000724,GO:0000976,GO:0000978,GO:0000981,GO:0000987,GO:0001217,GO:0001227,GO:0001228,GO:0003677,GO:0003682,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0005677,GO:0006275,GO:0006282,GO:0006338,GO:0006357,GO:0006403,GO:0006974,GO:0007283,GO:0009952,GO:0010225,GO:0010628,GO:0010629,GO:0016363,GO:0030183,GO:0031011,GO:0031519,GO:0032688,GO:0033044,GO:0034644,GO:0034696,GO:0045739,GO:0045893,GO:0045944,GO:0045995,GO:0046332,GO:0046872,GO:0048593,GO:0051726,GO:0060382,GO:0061052,GO:0071347,GO:0071707,GO:0140297,GO:1902894,GO:1904507,GO:1990837","negative regulation of transcription by RNA polymerase II|four-way junction DNA binding|telomere maintenance|double-strand break repair via homologous recombination|transcription cis-regulatory region binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|cis-regulatory region sequence-specific DNA binding|DNA-binding transcription repressor activity|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA binding|chromatin binding|RNA binding|protein binding|nucleus|nucleoplasm|transcription regulator complex|chromatin silencing complex|regulation of DNA replication|regulation of DNA repair|chromatin remodeling|regulation of transcription by RNA polymerase II|RNA localization|DNA damage response|spermatogenesis|anterior/posterior pattern specification|response to UV-C|positive regulation of gene expression|negative regulation of gene expression|nuclear matrix|B cell differentiation|Ino80 complex|PcG protein complex|negative regulation of interferon-beta production|regulation of chromosome organization|cellular response to UV|response to prostaglandin F|positive regulation of DNA repair|positive regulation of DNA-templated transcription|positive regulation of transcription by RNA polymerase II|regulation of embryonic development|SMAD binding|metal ion binding|camera-type eye morphogenesis|regulation of cell cycle|regulation of DNA strand elongation|negative regulation of cell growth involved in cardiac muscle cell development|cellular response to interleukin-1|immunoglobulin heavy chain V-D-J recombination|DNA-binding transcription factor binding|negative regulation of miRNA transcription|positive regulation of telomere maintenance in response to DNA damage|sequence-specific double-stranded DNA binding","WP1982,WP2817,WP5087","Sterol regulatory element-binding proteins (SREBP) signaling|Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4)|Pleural mesothelioma","R-HSA-1266738,R-HSA-162582,R-HSA-212436,R-HSA-392499,R-HSA-5617472,R-HSA-5619507,R-HSA-5688426,R-HSA-5689603,R-HSA-5696394,R-HSA-5696398,R-HSA-5696399,R-HSA-597592,R-HSA-73857,R-HSA-73894,R-HSA-74160,R-HSA-8864260,R-HSA-8866910,R-HSA-8939211,R-HSA-9006931,R-HSA-9018519","Developmental Biology|Signal Transduction|Generic Transcription Pathway|Metabolism of proteins|Activation of anterior HOX genes in hindbrain development during early embryogenesis|Activation of HOX genes during differentiation|Deubiquitination|UCH proteinases|DNA Damage Recognition in GG-NER|Nucleotide Excision Repair|Global Genome Nucleotide Excision Repair (GG-NER)|Post-translational protein modification|RNA Polymerase II Transcription|DNA Repair|Gene expression (Transcription)|Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors|TFAP2 (AP-2) family regulates transcription of growth factors and their receptors|ESR-mediated signaling|Signaling by Nuclear Receptors|Estrogen-dependent gene expression","chromosome_remodelling_factor"]
["ZBTB32",0,0,0,0.00822021598918371,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,27033,"zinc finger and BTB domain containing 32","protein_coding",null,null,"GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0001227,GO:0001817,GO:0002682,GO:0003677,GO:0005515,GO:0005634,GO:0005654,GO:0008270,GO:1990837","negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|regulation of cytokine production|regulation of immune system process|DNA binding|protein binding|nucleus|nucleoplasm|zinc ion binding|sequence-specific double-stranded DNA binding"]
["ZBTB42",1.02546921485495,0.968570442811998,1.13105965117988,1.2860953249478,1.00204535017691,1.31313797933595,1.06380286134159,1.23762697236676,1.15410687638279,1.560914503284,1.30833940705186,1.14714300678766,0.927474474020281,1.44256030027183,1.14708439823545,1.14908251137744,1.53059923288384,1.59244287760097,1.4647208014444,1.28953231221385,1.14387103836082,1.2133205497403,1.19643002805558,1.28910058616975,1.19441419950882,1.24012025668205,1.00620643449503,1.21350173619136,100128927,"zinc finger and BTB domain containing 42","protein_coding",null,null,"GO:0000122,GO:0000981,GO:0003677,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005886,GO:0006357,GO:0007517,GO:0046872","negative regulation of transcription by RNA polymerase II|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA binding|protein binding|nucleus|nucleoplasm|cytoplasm|plasma membrane|regulation of transcription by RNA polymerase II|muscle organ development|metal ion binding",{"$nulls":4},"ZBTB"]
["ZC3H12A-DT",1.26563869709971,1.63505592744681,1.57839096907381,1.08700403444917,0.793721506150349,1.22397682366932,1.85055365461791,1.14846334859309,1.76708462068163,1.40090844885933,1.54556152445253,1.67244352845307,1.77847024937333,1.8729803138094,1.44055263417846,1.3970355755273,1.63455439963172,1.64296694997895,2.33946055234807,1.76201949520647,1.60465332985511,2.17264751826071,1.75297937367393,2.14079619754047,1.87281133244638,1.2205334292761,1.68172611375951,2.48624707501389,728431,"ZC3H12A divergent transcript","non_coding"]
["ZCCHC8",4.56512112737232,4.65608068220048,4.61121434559658,4.23579293341036,4.4393461549965,3.82720373891667,4.47474341835363,4.41721585958191,4.54763381085675,4.33322862716916,4.20012625117497,4.46008466169392,4.60814980533536,3.90132454014031,4.09719906785352,4.42751278276427,3.91845034811803,3.84226394831075,4.05143168457238,3.92976933385593,4.3036060897141,3.76945392181785,4.05067174395499,3.93339613887325,4.52596708888557,3.94572658851326,4.32710323670461,3.73329851619839,55596,"zinc finger CCHC-type containing 8","protein_coding",null,null,"GO:0000398,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0008270,GO:0016076,GO:0016604,GO:0031499,GO:0034470,GO:0071013","mRNA splicing, via spliceosome|RNA binding|protein binding|nucleus|nucleoplasm|nucleolus|zinc ion binding|snRNA catabolic process|nuclear body|TRAMP complex|ncRNA processing|catalytic step 2 spliceosome"]
["ZER1",11.8916307160214,13.6365222211888,13.3658445143215,14.735597139918,13.9059918076696,14.8926084349304,12.7901085504212,14.0857084936709,13.8114680299241,18.9244812735431,16.957992731805,13.9318736353224,13.1372732395015,15.8456108122984,14.5939437977053,15.5216649262203,12.1917264039999,14.026135758425,12.7161097350368,13.1131259267294,12.2991261996246,12.7348493684243,10.8893551427692,10.5971686808865,12.1201894394602,13.3267059485259,9.9317787110825,13.3213772843806,10444,"zyg-11 related cell cycle regulator","protein_coding",null,null,"GO:0006515,GO:0031462,GO:0032436","protein quality control for misfolded or incompletely synthesized proteins|Cul2-RING ubiquitin ligase complex|positive regulation of proteasomal ubiquitin-dependent protein catabolic process"]
["ZFP36L1",72.8091787565135,93.8076218592546,89.5835487458467,79.1415915296192,86.1234006829127,86.0593660973632,87.9536640232482,79.4487975383745,89.8706559946905,99.7737707985845,84.8484708356638,84.5304692480239,100.340295569312,90.7679651236082,111.706964700306,106.571080651782,61.1553776714914,63.6075107681114,59.8078958686182,71.0247855186852,68.9221961692788,63.4205970643385,66.3189276557784,64.2252718853171,63.8774703463601,60.8007428491523,57.7155320590555,59.7274682601077,677,"ZFP36 ring finger protein like 1","protein_coding","hsa04218","Cellular senescence","GO:0000165,GO:0000288,GO:0000932,GO:0001570,GO:0003342,GO:0003677,GO:0003723,GO:0003729,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0006397,GO:0006915,GO:0007507,GO:0008283,GO:0009611,GO:0010468,GO:0010837,GO:0021915,GO:0031086,GO:0031440,GO:0032869,GO:0033077,GO:0035264,GO:0035925,GO:0038066,GO:0043488,GO:0043491,GO:0044344,GO:0045577,GO:0045600,GO:0045616,GO:0045647,GO:0045657,GO:0045661,GO:0046872,GO:0048382,GO:0051028,GO:0060710,GO:0061158,GO:0070371,GO:0071320,GO:0071356,GO:0071364,GO:0071375,GO:0071385,GO:0071456,GO:0071472,GO:0071560,GO:0071889,GO:0072091,GO:0097403,GO:1900153,GO:1901991,GO:1902172,GO:1904582,GO:1990904","MAPK cascade|nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|P-body|vasculogenesis|proepicardium development|DNA binding|RNA binding|mRNA binding|protein binding|nucleus|cytoplasm|cytosol|mRNA processing|apoptotic process|heart development|cell population proliferation|response to wounding|regulation of gene expression|regulation of keratinocyte proliferation|neural tube development|nuclear-transcribed mRNA catabolic process, deadenylation-independent decay|regulation of mRNA 3'-end processing|cellular response to insulin stimulus|T cell differentiation in thymus|multicellular organism growth|mRNA 3'-UTR AU-rich region binding|p38MAPK cascade|regulation of mRNA stability|phosphatidylinositol 3-kinase/protein kinase B signal transduction|cellular response to fibroblast growth factor stimulus|regulation of B cell differentiation|positive regulation of fat cell differentiation|regulation of keratinocyte differentiation|negative regulation of erythrocyte differentiation|positive regulation of monocyte differentiation|regulation of myoblast differentiation|metal ion binding|mesendoderm development|mRNA transport|chorio-allantoic fusion|3'-UTR-mediated mRNA destabilization|ERK1 and ERK2 cascade|cellular response to cAMP|cellular response to tumor necrosis factor|cellular response to epidermal growth factor stimulus|cellular response to peptide hormone stimulus|cellular response to glucocorticoid stimulus|cellular response to hypoxia|cellular response to salt stress|cellular response to transforming growth factor beta stimulus|14-3-3 protein binding|regulation of stem cell proliferation|cellular response to raffinose|positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|negative regulation of mitotic cell cycle phase transition|regulation of keratinocyte apoptotic process|positive regulation of intracellular mRNA localization|ribonucleoprotein complex","WP5072","Modulators of TCR signaling and T cell activation","R-HSA-450385,R-HSA-450531,R-HSA-8953854","Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA|Regulation of mRNA stability by proteins that bind AU-rich elements|Metabolism of RNA"]
["ZFP69B",0.881511312040651,0.833699514216405,0.747656278619255,0.879045338040663,0.998412798097084,0.794860815511086,0.775712429107962,0.800558981989254,0.896756804163738,0.728410598664289,0.838430999415017,0.972537550705193,0.976439974626285,0.907264157739373,0.894327915370007,0.740828601366577,0.553777095981593,0.481963991699037,0.532339936248357,0.688739977495293,0.595647793085201,0.614149204271334,0.791132479812996,0.572510527340752,0.566081757598871,0.656750076763576,0.610686423961895,0.673337134860129,65243,"ZFP69 zinc finger protein B","protein_coding","hsa05168","Herpes simplex virus 1 infection","GO:0000122,GO:0000977,GO:0001227,GO:0005515,GO:0005634,GO:0005730,GO:0007030,GO:0046872","negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleus|nucleolus|Golgi organization|metal ion binding",null,null,"R-HSA-212436,R-HSA-73857,R-HSA-74160","Generic Transcription Pathway|RNA Polymerase II Transcription|Gene expression (Transcription)"]
["ZGLP1",0.844083507366198,0.647470531820013,0.536824902624391,1.08371923269523,0.625253790180852,0.434672138272496,0.927243986316511,0.627454287445342,0.780563136535372,0.576939785432112,0.88343564601283,1.10946240888031,0.59556343286075,0.856648367886545,0.519108234589058,0.748685874411374,0.287964089910428,0.592048948893931,0.616546435254915,0.274926784405146,0.642491667144571,0.595278939784914,0.698893624780254,0.678338230879497,0.755859086860885,0.478631495338303,0.698235769157586,0.934324834239799,100125288,"zinc finger GATA like protein 1","protein_coding",null,null,"GO:0000122,GO:0000981,GO:0005634,GO:0005654,GO:0006357,GO:0007283,GO:0008270,GO:0043565,GO:0045944,GO:0048599","negative regulation of transcription by RNA polymerase II|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|spermatogenesis|zinc ion binding|sequence-specific DNA binding|positive regulation of transcription by RNA polymerase II|oocyte development"]
["ZMYM4-AS1",0.646009515441556,0,0.110272155534422,0.281618510740553,0.459093312773592,0.0551487141983559,0.219171288734496,0.172765886405476,0.118145091185264,0.282813620309859,0,0.0590853860938439,0.111699876580873,0.559900894043493,0.163850518808598,0.167049586582659,0.282317735206302,0,0.0542777974214011,0.112948445507249,0,0,0.463820806792325,0.286878913482294,0.407571076248516,0,0.22732056117598,0.0552112445696362,100861513,"ZMYM4 antisense RNA 1","non_coding"]
["ZNF10",1.70694145497794,2.07167057861684,1.6484886365202,1.71333480515364,2.03262886948044,1.63163090967791,1.35282060272382,1.36185474370145,1.9138780778036,1.467228846066,1.62254082807937,1.73579078647638,1.93165238225218,1.76151480096507,1.9174527009283,1.96649135435379,1.03525900685002,1.33029609488196,1.14219900620006,1.45316660377818,1.2992738888466,1.50620175008634,1.52809007122027,1.33888980338608,1.34656239957108,1.28473193636524,1.45640455314484,1.14458699279054,7556,"zinc finger protein 10","protein_coding","hsa05168","Herpes simplex virus 1 infection","GO:0000122,GO:0000977,GO:0001227,GO:0005515,GO:0005634,GO:0032991,GO:0046872","negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleus|protein-containing complex|metal ion binding",null,null,"R-HSA-212436,R-HSA-73857,R-HSA-74160","Generic Transcription Pathway|RNA Polymerase II Transcription|Gene expression (Transcription)"]
["ZNF146",23.4178449347564,21.9041820014835,22.7918761470208,22.0718507792908,25.7666121794178,22.0319113222432,23.7115937999633,20.3287859670443,26.8484719718513,18.2768302125246,24.0459433828428,25.2959309214269,29.5097111442096,22.7389750593413,27.3903450608373,24.9460715963438,25.7262036206743,23.073730781518,27.4102876978075,27.0511526989862,26.4196352892595,24.7785493040692,39.9755557854135,30.9829226560877,25.8734852868477,23.5276422516389,34.0838766413236,23.3681592640985,7705,"zinc finger protein 146","protein_coding",null,null,"GO:0000978,GO:0000981,GO:0003677,GO:0005515,GO:0005634,GO:0005730,GO:0005829,GO:0006355,GO:0006357,GO:0008201,GO:0008270","RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA binding|protein binding|nucleus|nucleolus|cytosol|regulation of DNA-templated transcription|regulation of transcription by RNA polymerase II|heparin binding|zinc ion binding",{"$nulls":4},"zf-C2H2"]
["ZNF213",3.552674772383,4.68290346655328,5.76850337878927,5.1523842995442,3.78711735231716,4.53449101924278,3.94666837822507,4.17894527043847,3.8349855168547,5.89500280468551,5.75614906091403,4.03395027425214,3.12385907031107,3.91274517535555,3.88271144657779,4.10789675947714,3.77921311451705,4.13264404892784,4.47016205028749,4.28745301754973,3.66546940950614,4.50010185224285,3.66280524545682,3.27846764867603,3.36600895229054,4.30380493028147,3.33113969333443,4.19897487813604,7760,"zinc finger protein 213","protein_coding",null,null,"GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872","RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding",null,null,"R-HSA-212436,R-HSA-73857,R-HSA-74160","Generic Transcription Pathway|RNA Polymerase II Transcription|Gene expression (Transcription)"]
["ZNF225-AS1",0.858171684073494,0.663691007505596,0.722855141545489,0.530743222473315,1.11286759669581,0.640174675527776,0.463937558375952,0.707820962750194,0.798665737659863,0.455749815626974,0.663750984055278,0.839184763634553,0.602551208672875,0.703466080144857,0.648918255239884,0.920139540733345,0.786524946556898,0.593671801735797,0.711602756791615,0.794386143743861,0.938676311320054,0.769982292913517,1.13224510173415,0.893259507698573,0.866714350141944,0.807796732323898,0.760587137966228,0.512720430082561,100379224,"ZNF225 and ZNF224 antisense RNA 1","non_coding"]
["ZNF281",6.55616830248614,7.27973056249181,6.34247396554023,5.0068112021784,7.24579783340356,6.54689162208945,6.3443531875127,5.64096247606892,7.05172440587541,5.00670812974701,5.12331395183964,5.84333088887621,7.92137908675818,5.54250085061463,7.54547808572687,7.04122250024195,4.25729804799731,3.81508585698938,4.4100598814022,5.72898712216433,5.04773366946189,4.81482499154192,6.21523695417561,5.69591476954639,5.21423556961253,3.87042371513731,5.1054590345367,4.50674269895261,23528,"zinc finger protein 281","protein_coding",null,null,"GO:0000122,GO:0000976,GO:0000978,GO:0000981,GO:0001227,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0006355,GO:0010172,GO:0010629,GO:0043565,GO:0045892,GO:0045893,GO:0046872,GO:0048863,GO:1990837","negative regulation of transcription by RNA polymerase II|transcription cis-regulatory region binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|regulation of DNA-templated transcription|embryonic body morphogenesis|negative regulation of gene expression|sequence-specific DNA binding|negative regulation of DNA-templated transcription|positive regulation of DNA-templated transcription|metal ion binding|stem cell differentiation|sequence-specific double-stranded DNA binding","WP2853,WP2857","Endoderm differentiation|Mesodermal commitment pathway",null,null,"zf-C2H2"]
["ZNF295-AS1",0.0195902727000313,0.0372671992152217,0.0183920491970566,0.0187882116903944,0.153142318723167,0.036792528803845,0,0.0192101603343298,0,0,0,0,0,0,0,0,0.0188348605319321,0,0,0,0,0,0.0193399119111262,0.0191391600709844,0.0194222512456467,0,0,0,150142,"ZNF295 antisense RNA 1","non_coding"]
["ZNF333",1.09340821332353,1.00686480827369,0.963139424403328,0.749925336430819,1.10887115913223,0.965405513384406,0.928693177093046,0.826570854876748,1.18088290660656,0.952398175208311,0.977077689208283,1.07814597372338,1.13096125038134,1.13587586595169,1.25993846743205,1.40431795313994,0.797857841227262,0.697301733465345,0.726711114651644,0.923679354845343,0.84082514849227,0.809513942839375,0.853656460852839,0.885226361602507,0.960943187034129,0.627085945145053,0.832545942631124,0.673683359219888,84449,"zinc finger protein 333","protein_coding","hsa05168","Herpes simplex virus 1 infection","GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872","RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding",null,null,"R-HSA-212436,R-HSA-73857,R-HSA-74160","Generic Transcription Pathway|RNA Polymerase II Transcription|Gene expression (Transcription)"]
["ZNF382",0.527094899633472,0.489051518300328,0.573789573222568,0.648175272405278,0.654088185678942,0.48282249411111,0.579268454102498,0.46930311081641,0.484648568333218,0.448484861996172,0.559565764269163,0.588862139070352,0.528939650690189,0.62892130655778,0.598459302563026,0.588681460586877,0.438371437255679,0.451797879334717,0.484163682900737,0.491317608269958,0.506655856902777,0.62089982881054,0.641669323024429,0.625530936062808,0.375099216955272,0.439382818871216,0.613323745370559,0.51377056771968,84911,"zinc finger protein 382","protein_coding","hsa05168","Herpes simplex virus 1 infection","GO:0000978,GO:0003700,GO:0005634,GO:0006357,GO:0046872","RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity|nucleus|regulation of transcription by RNA polymerase II|metal ion binding",null,null,"R-HSA-212436,R-HSA-73857,R-HSA-74160","Generic Transcription Pathway|RNA Polymerase II Transcription|Gene expression (Transcription)","zf-C2H2"]
["ZNF407-AS1",2.44421640734069,2.79720688824625,3.29273799142422,2.72367415620889,2.70683676997046,2.14222751474131,3.17812563696673,2.58701249591619,2.5522094374309,2.3391470575162,2.91891330063562,2.84941570501788,3.19516628825834,2.9886523370135,3.08853983122114,2.83248586576038,2.61853356369327,3.00821696114224,3.19845279830878,3.26818960588204,2.85625829228001,3.23789366999476,3.53137661544506,3.07019894195688,2.65403889215123,2.91227257701292,3.63418441196108,2.640699474727,400657,"ZNF407 antisense RNA 1","non_coding"]
["ZNF438",0.547773357721517,0.696982984253308,0.778170552123592,0.783411493514629,0.60334251843484,0.559508773139684,0.878677621199208,0.577195120491022,0.674232554468634,0.66178387152507,0.540002862908098,0.729973088195762,0.498079904208351,0.684860593577746,0.717218407330363,0.669716978935935,0.831554056425837,0.869178244120878,1.02140946056636,0.730057679596858,0.725637647598574,0.753614003052513,0.851480128832956,0.701810141982594,0.819376657185329,0.96791615591466,0.764882024593271,0.851507967385344,220929,"zinc finger protein 438","protein_coding",null,null,"GO:0000981,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006357,GO:0043565,GO:0046872","DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|nucleoplasm|cytosol|regulation of transcription by RNA polymerase II|sequence-specific DNA binding|metal ion binding"]
["ZNF485",0.211457350071825,0.179268955570084,0.427257590351268,0.242478148146155,0.359351689227624,0.289220396954645,0.394575596038553,0.333570151071418,0.268183715683331,0.154959099941264,0.237771471841937,0.235867974602795,0.301641097475516,0.153390311439439,0.162453430483149,0.222286480918228,0.207723073042481,0.293481057871647,0.216676152769028,0.300592332978536,0.104130982342121,0.266540832593948,0.313132434599244,0.282935796083475,0.323580535077541,0.174715231881169,0.400350118612711,0.237688927210175,220992,"zinc finger protein 485","protein_coding","hsa05168","Herpes simplex virus 1 infection","GO:0000978,GO:0001228,GO:0005515,GO:0005634,GO:0006357,GO:0045944,GO:0046872","RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase II|metal ion binding",null,null,"R-HSA-212436,R-HSA-73857,R-HSA-74160","Generic Transcription Pathway|RNA Polymerase II Transcription|Gene expression (Transcription)"]
["ZNF510",1.73770928188513,1.75615294932003,1.63482247023463,1.44782776823191,1.93149361213136,1.69638955797819,1.49291675785244,1.56199294558375,1.81708768668843,1.31450221056349,1.42653361331084,1.6208011733277,2.07945386675901,1.77059070397178,1.9628394342208,1.69910024709074,2.23108358137693,1.8155206850887,1.91050411608616,2.07136618387438,2.20735493314874,1.72746223530758,2.85559539524281,2.196392119798,2.2934845983417,1.53418088036874,2.34365941582291,1.75276793548126,22869,"zinc finger protein 510","protein_coding","hsa05168","Herpes simplex virus 1 infection","GO:0000977,GO:0000981,GO:0005634,GO:0006357,GO:0046872","RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding",null,null,"R-HSA-212436,R-HSA-73857,R-HSA-74160","Generic Transcription Pathway|RNA Polymerase II Transcription|Gene expression (Transcription)"]
["ZNF555",0.457518027892938,0.408532151286226,0.388626271730162,0.405952058987837,0.450108632423156,0.534848925819109,0.418148755922967,0.418120972745085,0.547858471854079,0.392686760780776,0.418561247926441,0.422725545468772,0.491332432525292,0.421351119639381,0.471800956998918,0.599052431551878,0.607447629911503,0.41468602541753,0.396959270784712,0.508796166893585,0.578709848023118,0.553224550445431,0.470106566773534,0.526040731621949,0.595534975037975,0.416980564845041,0.722827416555422,0.550085292276071,148254,"zinc finger protein 555","protein_coding","hsa05168","Herpes simplex virus 1 infection","GO:0000122,GO:0000977,GO:0001227,GO:0005515,GO:0005634,GO:0046872","negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleus|metal ion binding","WP3888","VEGFA-VEGFR2 signaling","R-HSA-212436,R-HSA-73857,R-HSA-74160","Generic Transcription Pathway|RNA Polymerase II Transcription|Gene expression (Transcription)"]
["ZNF562",1.6636880390101,1.5148175673773,1.34261127546236,1.25658731269471,1.45696393776657,1.31239809752277,1.23001421198959,1.31269525460474,1.48954962722654,1.15235787587627,1.27613481738519,1.33455052884322,1.47203939085053,1.2297778001687,1.51510488025077,1.54083416712264,1.33978168131649,1.17847823132302,1.33860828400223,1.5607696252364,1.45140174863046,1.29948723570818,1.43787508456833,1.58171672595076,1.27482563775193,1.05000826138779,1.4133488869604,1.25850433072103,54811,"zinc finger protein 562","protein_coding","hsa05168","Herpes simplex virus 1 infection","GO:0000978,GO:0000981,GO:0005634,GO:0006355,GO:0006357,GO:0046872","RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of DNA-templated transcription|regulation of transcription by RNA polymerase II|metal ion binding",null,null,"R-HSA-212436,R-HSA-73857,R-HSA-74160","Generic Transcription Pathway|RNA Polymerase II Transcription|Gene expression (Transcription)"]
["ZNF582-DT",0.876305881009844,0.460297827861564,0.970057892244949,1.12893359327435,0.613460933225848,0.577255318486721,0.622341181220988,0.949080720952353,0.631482932798095,0.692831620060397,0.98401793366406,1.44746295190595,0.870673710466637,1.13471617871434,0.596015205971887,0.756464721773877,0.880239576145415,0.617187513387523,0.942869336866086,0.742056490243043,0.506137540405592,0.857825546414942,1.0329633688388,0.677234675233747,0.544614625904131,0.795365449588493,0.759389647596617,0.909900598278634,386758,"ZNF582 divergent transcript","non_coding"]
["ZNF620",0.117481044888589,0.129767185457979,0.0996216605460701,0.0835947312776049,0.137016408878706,0.135231811197486,0.0777868576423782,0.118917725269395,0.0800506490886239,0.0766495286423937,0.114048135036222,0.0838808138304001,0.0504557434914027,0.0830995886182646,0.116305534860763,0.150915316094498,0.0910894421901398,0.115714045666249,0.115583550898631,0.116616530831609,0.103730835167837,0.0972610227473931,0.164616283810941,0.129585540421567,0.0676297369397128,0.108027216338167,0.135687652553482,0.0855064066046834,253639,"zinc finger protein 620","protein_coding","hsa05168","Herpes simplex virus 1 infection","GO:0000122,GO:0000977,GO:0001227,GO:0005515,GO:0005634,GO:0046872","negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleus|metal ion binding",null,null,"R-HSA-212436,R-HSA-73857,R-HSA-74160","Generic Transcription Pathway|RNA Polymerase II Transcription|Gene expression (Transcription)"]
["ZNF627",3.25379241799303,3.17876896623077,2.90576328197501,2.68927713867926,3.10192096020233,3.26248752630548,2.74781432701428,3.28577318796675,3.65426593128279,2.58179138525067,3.54097984325832,4.28493714126493,3.9915989262178,4.17815739783722,4.76452867793677,5.15017645935312,5.34104151060559,4.12022455612192,4.4334147546399,4.63825728800158,4.65242150493264,4.41715921056425,5.58001692646512,4.97936208731956,4.35363389649228,4.2898218949346,5.79383001444777,4.31899307004849,199692,"zinc finger protein 627","protein_coding","hsa05168","Herpes simplex virus 1 infection","GO:0000977,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872","RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding",null,null,"R-HSA-212436,R-HSA-73857,R-HSA-74160","Generic Transcription Pathway|RNA Polymerase II Transcription|Gene expression (Transcription)"]
["ZNF628",1.14374082248126,1.28650570811983,1.40795022247664,1.56571959055952,1.21500095967268,1.59544841804617,1.12908906205674,1.14947105865305,1.05497534372729,1.54493910852507,1.86113869026065,1.12682488789252,1.04255512447125,1.33926716669586,1.20932067772782,1.2239323231028,1.04488378398836,1.56324341885059,1.07461438539149,1.04508134293243,1.12879451492413,1.41196482755014,0.646552322707735,0.918032725883727,0.936316641740838,1.27615327416189,0.81745354265845,1.12432645015505,89887,"zinc finger protein 628","protein_coding",null,null,"GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006355,GO:0006357,GO:0007283,GO:0046872","RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of DNA-templated transcription|regulation of transcription by RNA polymerase II|spermatogenesis|metal ion binding"]
["ZNF629",6.83844988268704,8.60123537757595,7.86762553944597,7.98201563008711,7.98588754796984,9.45410015126948,7.5301339123946,7.65877799675956,8.54486985826876,9.82839899961785,10.3197792277605,9.86229212220386,7.51997177954866,9.62360629607057,9.30540446419627,9.02215599038912,6.82109628902874,8.12994348387016,7.49610005803881,8.29221507901011,7.58026451891276,7.98247910083516,6.87752876620323,6.73276883677029,7.5593871803312,7.61849462204354,6.17713449699996,7.87419838481644,23361,"zinc finger protein 629","protein_coding",null,null,"GO:0000978,GO:0001228,GO:0005515,GO:0005634,GO:0006357,GO:0045944,GO:0046872","RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase II|metal ion binding"]
["ZNF630",0.781669529625574,0.613565824917276,0.470239960551771,0.640491829157231,0.637748079547606,0.584371425956565,0.587680784552231,0.639992548795961,0.778620056181266,0.555499455568081,0.599511263892373,0.572639193772684,0.902136883280918,0.991223195949803,0.536389029478147,0.532470557232227,0.693156804260745,0.610901571403995,0.799588971810877,0.605714657726588,0.830898007374803,0.973842419485089,0.936504743444174,0.630212883418451,0.8502046738972731,0.879734477826884,1.03547011533983,0.991704001910857,57232,"zinc finger protein 630","protein_coding","hsa05168","Herpes simplex virus 1 infection","GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872","RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding"]
["ZNF630-AS1",0.0240251472684876,0,0.0451113363549908,0.0230415145151361,0.0469527251700264,0.203047538639401,0,0.0471179690196752,0.0724981241364123,0,0.0225942620463639,0,0.045695404055812,0.0229050365745065,0,0,0,0,0,0,0,0,0.118590547191219,0.0469438222061935,0.142914533229999,0,0,0,100874120,"ZNF630 antisense RNA 1","non_coding"]
["ZNF638",14.326795151448,13.6948998246886,14.9289124489662,14.176608867229,16.2264772653978,13.669085992501,14.1161365304347,13.431920050869,15.2465693929116,11.0472155744233,13.9349190885067,14.1273392306468,16.834219048193,13.7041106144069,15.0090971278,15.4334398763778,18.3087340124028,14.6325732235416,17.0624443080332,16.9729285243063,17.2455966750911,14.8742807853326,22.8775630341009,20.2203020918678,18.0481148542726,15.5228418628086,20.0471510482791,15.8457001257584,27332,"zinc finger protein 638","protein_coding",null,null,"GO:0003690,GO:0003723,GO:0003729,GO:0005634,GO:0005654,GO:0005737,GO:0008270,GO:0008380,GO:0016607,GO:0043231,GO:0043484","double-stranded DNA binding|RNA binding|mRNA binding|nucleus|nucleoplasm|cytoplasm|zinc ion binding|RNA splicing|nuclear speck|intracellular membrane-bounded organelle|regulation of RNA splicing",null,null,"R-HSA-1266738,R-HSA-381340","Developmental Biology|Transcriptional regulation of white adipocyte differentiation"]
["ZNF639",3.89773308488585,4.67145424014039,4.25406013122784,3.75602167950897,4.4750412593659,4.24803669033634,4.17890327198019,3.61747979179395,4.24293417464537,3.3341122103939,3.76371556610531,3.82396959654628,4.78045053082581,3.50640837339239,4.9070897427212,4.81564193203777,3.74026899198007,3.79261822331596,4.3462604891797,4.99155154323636,3.85825394121658,3.95287942104293,5.49597841744902,4.28852646606865,3.7608609390188,3.72833223699886,4.70929705830752,3.40508520075395,51193,"zinc finger protein 639","protein_coding",null,null,"GO:0000976,GO:0000978,GO:0001228,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0030307,GO:0043621,GO:0043922,GO:0043923,GO:0045892,GO:0045944,GO:0046718,GO:0046872","transcription cis-regulatory region binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|positive regulation of cell growth|protein self-association|negative regulation by host of viral transcription|positive regulation by host of viral transcription|negative regulation of DNA-templated transcription|positive regulation of transcription by RNA polymerase II|viral entry into host cell|metal ion binding",{"$nulls":4},"zf-C2H2"]
["ZNF641",0.92103853917761,1.06378770447196,1.02712188403889,0.90903492201458,0.957142952706744,0.972442865610077,1.06846746178009,0.934228836882834,1.29652570441043,0.959827962657329,1.1480368589014,1.19384738404729,1.23274742215178,1.18473470384743,1.09676024756524,1.27758279591179,1.08699090614295,1.02354722977248,0.932314266726853,1.06142237318023,1.07170606786758,1.00054980356461,1.21476254079394,1.09265002931145,1.05566598038708,1.19002187822495,1.08225895211779,0.987289641323924,121274,"zinc finger protein 641","protein_coding","hsa05168","Herpes simplex virus 1 infection","GO:0000122,GO:0000977,GO:0001227,GO:0005654,GO:0005730,GO:0005829,GO:0046872","negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|nucleoplasm|nucleolus|cytosol|metal ion binding",null,null,"R-HSA-212436,R-HSA-73857,R-HSA-74160","Generic Transcription Pathway|RNA Polymerase II Transcription|Gene expression (Transcription)"]
["ZNF644",3.71809865313698,3.40542164545082,3.23186911538953,2.56593713379952,3.86455956470573,3.37532256902257,2.69404388322087,3.02212318089327,4.40469591596637,2.35897039579132,2.82524553738262,3.03310921216263,4.88704168295549,2.98203935589193,4.04616471272686,3.9810673994507,4.0980231177236,3.00856242884373,3.88058852910852,4.15997403049042,4.65687260343769,3.58458224763853,7.57493660580302,5.22082761211537,4.23633753982403,3.11308319460253,5.84151550367956,3.05685123336384,84146,"zinc finger protein 644","protein_coding",null,null,"GO:0000978,GO:0000981,GO:0001222,GO:0005634,GO:0006357,GO:0046872","RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|transcription corepressor binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding"]
["ZNF646",2.5409547147975,3.26408735421517,3.1115729133381,2.96006735164813,2.70894012458619,2.96963959943821,2.65091856168279,2.85727515923564,2.51071180362886,3.77397535104318,3.24352090855588,2.83775576861549,2.89248747386636,3.14989429329184,2.97631697401924,2.98860011528498,2.25377632356894,2.49160816149227,2.69300737831213,2.9314591520717,2.83818719089186,2.62857630111836,2.09949010943406,2.31717183465963,2.26929901951697,2.56198137655504,2.24836426073222,2.52510833226258,9726,"zinc finger protein 646","protein_coding",null,null,"GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006355,GO:0006357,GO:0046872","RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of DNA-templated transcription|regulation of transcription by RNA polymerase II|metal ion binding"]
["ZNF648",0,0,0,0,0,0,0,0,0.00248823514976766,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,127665,"zinc finger protein 648","protein_coding",null,null,"GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006355,GO:0006357,GO:0046872","RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of DNA-templated transcription|regulation of transcription by RNA polymerase II|metal ion binding"]
["ZNF649",1.4356380294459,1.23700948974034,0.991050270016834,1.02859572973678,1.44410519848601,1.07057959752541,0.890331863470561,0.919198950132894,1.17223470643123,1.3583027843115,1.38190244072291,1.45286744020041,1.23678218608954,1.54583164129902,1.36655028562734,1.17704017914492,1.87555558560082,1.32053151015095,1.24099246040453,1.08006951016307,1.99269032103109,1.15591922272716,1.46731281547271,1.61709113862914,1.92567483528266,1.28387233051526,1.266660504767,1.46081480932744,65251,"zinc finger protein 649","protein_coding","hsa05168","Herpes simplex virus 1 infection","GO:0000978,GO:0003700,GO:0005515,GO:0005615,GO:0005634,GO:0006357,GO:0046872","RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity|protein binding|extracellular space|nucleus|regulation of transcription by RNA polymerase II|metal ion binding",null,null,"R-HSA-212436,R-HSA-73857,R-HSA-74160","Generic Transcription Pathway|RNA Polymerase II Transcription|Gene expression (Transcription)"]
["ZNF649-AS1",0.790095963791608,0.132619826172789,0.349068409588274,0.222867062810196,0.0454146186558359,0.0436435514086989,0.0433619058315232,0.410170044104035,0.140246371174232,0,0.349665682979591,0.561107425180848,0.265190913882523,0,0.821230100304474,0.0440665288743912,0.402156746254219,0,0.214771629451923,0.0446925314550237,0.131600017339267,0.176709490370934,0.275293642652169,0.0908120146816365,0.276465700489757,0.132482343071273,0.53969036679194,0.26215821990479,101928571,"ZNF649 antisense RNA 1","non_coding"]
["ZNF652",1.36856356999569,1.48525375029633,1.47231912833206,1.4803640906164,1.4776098813932,1.40945241927618,1.32081483946906,1.42560974130541,1.50973496859552,1.35267530217416,1.69005080106802,1.59132214007802,1.5831261159451,1.74965883877951,1.49183749521985,1.57627239114738,1.10224456887063,1.3057252936161,1.13837007490772,1.42606930580332,1.12231503204579,1.3712450549092,1.26690829360914,1.22526306284145,1.25005908907811,1.37499360640763,1.18972940894125,1.15794729341216,22834,"zinc finger protein 652","protein_coding",null,null,"GO:0000981,GO:0003677,GO:0005515,GO:0005634,GO:0006357,GO:0046872","DNA-binding transcription factor activity, RNA polymerase II-specific|DNA binding|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding"]
["ZNF652-AS1",0.392342173800627,0.219519118665004,0.173338765035273,0.154938403255033,0.13531067887184,0.108361557435981,0.150727172667794,0.362098364658052,0.0696428897954234,0.0222279883086002,0.10852209767132,0.0696580279548142,0.04389575629334,0.308041365164682,0.0858531828003956,0.131294110002467,0.310646192882825,0.106770704496683,0.19197053180463,0.133159254677639,0.283180402607898,0.131624363546843,0.0911360232524304,0.0450950072905386,0.137286049900735,0.0877166198417104,0.133998464357588,0.3905439234883,102724596,"ZNF652 antisense RNA 1","non_coding"]
["ZNF653",1.37659409279328,1.30936937632682,1.2571486478092,1.95634652906926,1.41852160778302,1.57473389762492,1.45948847390224,1.42351390525737,1.35949128603433,2.54319557227386,2.11844807933317,1.80045844338051,1.02350067970135,1.6345518997278,1.41988569363105,1.0916388025708,1.4438310914729,2.01478401265273,2.4635921172229,1.34783047507815,1.85445644984736,2.79543912924307,1.49490156618146,1.77281579264754,1.46404461014538,2.05714613181237,1.39265503965577,1.87064616524448,115950,"zinc finger protein 653","protein_coding",null,null,"GO:0000122,GO:0003677,GO:0003712,GO:0003714,GO:0005515,GO:0005576,GO:0005634,GO:0006357,GO:0046872,GO:0050682,GO:0140297,GO:1900116","negative regulation of transcription by RNA polymerase II|DNA binding|transcription coregulator activity|transcription corepressor activity|protein binding|extracellular region|nucleus|regulation of transcription by RNA polymerase II|metal ion binding|AF-2 domain binding|DNA-binding transcription factor binding|extracellular negative regulation of signal transduction"]
["ZNF654",2.66620651529335,2.24545823945235,1.5613583835424,1.35990064514962,2.90379089402116,1.94417734185197,1.59034096709458,1.53466283678171,2.43527974120672,1.33661483586398,1.32641088332283,1.52143215991141,3.10217966552093,1.76890457610596,2.13585615431292,2.5959057048725,2.42924379149396,1.55972461485451,1.42203576926421,2.53124292588861,2.58413240539165,1.93211111079188,3.48469065293344,3.11324625038262,2.15729367948848,1.68772274203555,2.44501581485902,1.71239049907032,55279,"zinc finger protein 654","protein_coding",null,null,"GO:0003677,GO:0003700,GO:0005634,GO:0006355,GO:0046872","DNA binding|DNA-binding transcription factor activity|nucleus|regulation of DNA-templated transcription|metal ion binding"]
["ZNF655",2.52515247590828,2.45036095795678,2.4864449440275,2.20568449672239,2.33039088759437,2.24749491830887,2.41147176666588,2.12182446547851,2.15939452856713,2.20685609456803,2.12289144149295,2.4122044488929,2.32862799006132,1.985921937854,1.99651637529511,2.07177315692059,2.4318683196189,2.2341664677498,2.72276640094326,2.50591115494703,2.62411389250543,2.40833214916513,2.90836163401179,2.6248266915077,2.5372119009358,2.39530973431812,2.66979771681415,2.50182427805896,79027,"zinc finger protein 655","protein_coding",null,null,"GO:0000978,GO:0000981,GO:0003674,GO:0005515,GO:0005634,GO:0005730,GO:0005737,GO:0006357,GO:0046872,GO:2000134","RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|molecular_function|protein binding|nucleus|nucleolus|cytoplasm|regulation of transcription by RNA polymerase II|metal ion binding|negative regulation of G1/S transition of mitotic cell cycle","WP2446","Retinoblastoma gene in cancer","R-HSA-212436,R-HSA-73857,R-HSA-74160","Generic Transcription Pathway|RNA Polymerase II Transcription|Gene expression (Transcription)"]
["ZNF658",0.544609581060871,0.518014069091581,0.52969101687523,0.522312284992966,0.643197738637304,0.496699138851907,0.643369672570042,0.307362565349277,0.709385714660359,0.464151411681212,0.751679571405255,0.670121028619569,0.946412922315245,0.649957046565082,0.896367126005525,0.780131281526286,0.76846230970283,0.489407112937122,0.713366464569092,0.629203284408953,0.591690000440116,0.685262965566355,0.901239895058481,0.880401363265284,0.827387903064549,0.599379902906757,1.02747737224269,0.58934793622007,26149,"zinc finger protein 658","protein_coding","hsa05168","Herpes simplex virus 1 infection","GO:0000976,GO:0000978,GO:0001228,GO:0005634,GO:0006357,GO:0042254,GO:0045892,GO:0045944,GO:0046872,GO:0071294","transcription cis-regulatory region binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|ribosome biogenesis|negative regulation of DNA-templated transcription|positive regulation of transcription by RNA polymerase II|metal ion binding|cellular response to zinc ion",null,null,"R-HSA-212436,R-HSA-73857,R-HSA-74160","Generic Transcription Pathway|RNA Polymerase II Transcription|Gene expression (Transcription)"]
["ZNF66",0.190041614348486,0.158165967323646,0.0724822595366707,0.0797391738276622,0.185700665841003,0.0501915264052452,0.0443267774968644,0.0873535380701845,0.11947256411993,0.183034432919639,0.0558509848337086,0.0836489735710599,0.124250424511309,0.0339715149194928,0.0276152559789772,0.0450470795279081,0.114195937836257,0.164848886784039,0.0987977885647976,0.142771911455793,0.0616588169658901,0.101610876816069,0.0820806483930238,0.0928327270594389,0.217850992601534,0.039500500320876,0.160912307349289,0.0502484360689948,7617,"zinc finger protein 66","protein_coding","hsa05168","Herpes simplex virus 1 infection","GO:0000978,GO:0000981,GO:0005634,GO:0006355,GO:0006357,GO:0046872","RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of DNA-templated transcription|regulation of transcription by RNA polymerase II|metal ion binding"]
["ZNF660",0.45281266593312,0.646049958832818,0.494523552493501,0.310195500517448,0.790124064718435,0.5423650115068,0.375050011700147,0.385125189013235,1.04571771444619,0.734278009398943,0.877760357771017,0.939026196065996,1.06336980552368,1.02639219943896,0.975435784837405,0.911242036922618,0.675239758308993,0.534402566215829,0.474014312791046,0.826436457553644,0.5407766682116391,0.632446719051269,0.825629259673886,0.762889413703634,0.728364384046549,0.570744410214489,0.666210168811557,0.621169088072885,285349,"ZNF660-ZNF197 readthrough","protein_coding",null,null,"GO:0000978,GO:0003700,GO:0005515,GO:0005634,GO:0006357,GO:0046872,GO:1990837","RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding|sequence-specific double-stranded DNA binding",null,null,"R-HSA-212436,R-HSA-73857,R-HSA-74160","Generic Transcription Pathway|RNA Polymerase II Transcription|Gene expression (Transcription)"]
["ZNF662",0.958294881903761,1.17905139646601,1.14586304951509,1.01965425906865,1.22990562585454,1.23566673319853,0.867391501511368,0.84619838914518,1.46745230255882,1.40510450042451,1.6903497134842,1.77475612315484,1.3647279137369,1.90905013006198,1.43657550731868,1.50078719491559,1.10011042484352,1.38956765470179,1.15005763234638,1.29745881022773,1.11148558448434,1.09216716324943,1.57203998510134,1.21569886651097,1.16277933456781,1.29561201914059,1.42097463630044,1.07122899549587,389114,"zinc finger protein 662","protein_coding","hsa05168","Herpes simplex virus 1 infection","GO:0000978,GO:0003700,GO:0005634,GO:0006357,GO:0046872","RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity|nucleus|regulation of transcription by RNA polymerase II|metal ion binding",null,null,"R-HSA-212436,R-HSA-73857,R-HSA-74160","Generic Transcription Pathway|RNA Polymerase II Transcription|Gene expression (Transcription)"]
["ZNF664",21.573724206128,22.3872846640011,24.6970756950813,19.2275560691435,24.1780183606408,22.2195474043406,23.8025890225182,21.5045449014593,23.6181133793785,18.0266923217227,20.9061478963284,22.1578008304158,23.9526681887352,21.7301016881795,25.9877106489768,25.1970204689521,19.5157110376912,18.5847584185473,17.841585306752,20.0303800066606,19.6602450146238,19.847032974639,22.5076387815563,20.0020201632384,20.9114586658323,18.6218803653753,19.1766138756892,17.2315933225606,144348,"ZNF664-RFLNA readthrough","protein_coding",null,null,"GO:0000978,GO:0000981,GO:0003674,GO:0005515,GO:0005634,GO:0006355,GO:0006357,GO:0008150,GO:0046872","RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|molecular_function|protein binding|nucleus|regulation of DNA-templated transcription|regulation of transcription by RNA polymerase II|biological_process|metal ion binding",null,null,"R-HSA-212436,R-HSA-73857,R-HSA-74160","Generic Transcription Pathway|RNA Polymerase II Transcription|Gene expression (Transcription)"]
["ZNF664-RFLNA",0.0335137363057311,0.0106257078574689,0.0104879650622253,0,0,0.0104903687596541,0,0,0.0112367585690087,0.021518682423908,0.0210118209830255,0.0112392010845728,0.0106237553565315,0.0106504148514696,0,0.0211840752152067,0.0107404757944213,0,0,0.0214850130492447,0.0105439991789991,0,0,0,0,0,0,0,100533183,"zinc finger protein 664","protein_coding",null,null,"GO:0005515,GO:0005737,GO:0031005,GO:0032432,GO:0048705,GO:0061182,GO:0061572,GO:1900158","protein binding|cytoplasm|filamin binding|actin filament bundle|skeletal system morphogenesis|negative regulation of chondrocyte development|actin filament bundle organization|negative regulation of bone mineralization involved in bone maturation"]
["ZNF665",0.753128729976704,0.523486812960862,0.64723569819962,0.56116709819133,0.769891493568093,0.451536764413231,0.648611357376749,0.568088988180482,0.51862724264015,0.546809467817669,0.473998773993933,0.547882671052007,0.4738062463092,0.535750429948387,0.549548935423808,0.714080437809821,0.362043826773266,0.300178733708104,0.353383106615931,0.423392818942068,0.322612837119401,0.242296700745016,0.348874886346935,0.407512328938871,0.425027146107184,0.242205702068836,0.358788351875435,0.354014073014205,79788,"zinc finger protein 665","protein_coding","hsa05168","Herpes simplex virus 1 infection","GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872","RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding",null,null,"R-HSA-212436,R-HSA-73857,R-HSA-74160","Generic Transcription Pathway|RNA Polymerase II Transcription|Gene expression (Transcription)"]
["ZNF667",0.7418196573847,0.708860208183939,0.654531063589683,0.704860742413086,0.90944958087964,0.832057718537101,0.676089952307531,0.548937245644816,0.504355659363569,0.433311254315493,0.452173102591776,0.770518902332473,0.591152633868163,0.520602970419011,0.600458188687796,0.543799718024402,0.548118677954109,0.568805318652836,0.485637263283569,0.482171431215621,0.567265543803271,0.437439851943846,0.525521265435724,0.530132056658502,0.61288102796812,0.362220802944262,0.531737228078864,0.474616932710799,63934,"zinc finger protein 667","protein_coding","hsa05168","Herpes simplex virus 1 infection","GO:0000978,GO:0003700,GO:0005515,GO:0005634,GO:0006357,GO:0046872","RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding",null,null,"R-HSA-212436,R-HSA-73857,R-HSA-74160","Generic Transcription Pathway|RNA Polymerase II Transcription|Gene expression (Transcription)","zf-C2H2"]
["ZNF667-AS1",7.10567647816279,6.14033018320301,7.18203847770378,7.16274490593129,6.189938657174,6.97072942802539,7.41943366858166,7.11605535480547,5.01835024168031,3.72761992606726,3.78199814708997,3.93950072025925,3.06241217994456,4.5979388001538,4.51328689301552,5.01710900813315,5.84326459504168,4.63021968862072,6.28776166987684,5.80075469956342,5.86479942668434,5.86322683698512,7.10441847666954,6.08537269442621,5.92057318958715,5.01347464656704,7.27103875170334,6.16848636328601,100128252,"ZNF667 antisense RNA 1 (head to head)","non_coding"]
["ZNF668",3.76761447117058,3.63095737164001,4.08443178624254,4.30194555101665,3.25782820853388,3.96521000298653,3.58147386773024,3.68754022890295,3.17477544873314,4.36812796407066,4.83349180843426,4.01224362705134,2.92045689971892,2.96167196808876,3.29891760534811,3.25548454611602,3.56765636708648,4.09774250616426,4.86181346839481,4.0194991897208,4.3477980412087,4.47319197803427,3.65630419025283,3.27110049719534,3.74939594510897,4.57283024176917,3.87285716359529,4.93874192227457,79759,"zinc finger protein 668","protein_coding",null,null,"GO:0000122,GO:0000978,GO:0001227,GO:0001228,GO:0005634,GO:0006281,GO:0006357,GO:0045944,GO:0046872","negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|nucleus|DNA repair|regulation of transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase II|metal ion binding",null,null,"R-HSA-212436,R-HSA-73857,R-HSA-74160","Generic Transcription Pathway|RNA Polymerase II Transcription|Gene expression (Transcription)"]
["ZNF669",1.92152247094401,1.44909443465786,1.52050928921979,0.881936258737701,1.63622118945364,1.08264451355998,1.51104319506591,0.888284073789458,2.01562503581703,1.45409976470924,1.48438779625373,1.20135271022681,1.34440811229989,2.05438585170347,1.42960411929945,1.22327248178809,2.42804751981502,1.93030995860724,2.01692868310146,1.51781662324342,1.80067776610518,1.51336742771848,2.26280908242439,2.11863875392697,2.20440573812097,1.51279905665907,2.55006446223483,1.88387288370142,79862,"zinc finger protein 669","protein_coding","hsa05168","Herpes simplex virus 1 infection","GO:0000122,GO:0000977,GO:0001227,GO:0005515,GO:0005634,GO:0046872","negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleus|metal ion binding",null,null,"R-HSA-212436,R-HSA-73857,R-HSA-74160","Generic Transcription Pathway|RNA Polymerase II Transcription|Gene expression (Transcription)","zf-C2H2"]
["ZNF670",0.507395997994807,0.568144978457647,0.253255493732736,0.363426775761969,0.533462163386398,0.57900236893885,0.2876329421848,0.39048301130387,0.503911193068244,0.470129632160549,0.543618913853188,0.549253356790879,0.433665389313092,0.275548081164364,0.525633401295917,0.57852412222515,0.716308100706427,0.540788403123348,0.534242509287129,0.611447499677737,0.703204603811127,0.561664189075116,0.887691358246212,0.715331237878223,0.36295592320671,0.604172515221388,0.590440378251051,0.501163398706083,93474,"zinc finger protein 670","protein_coding","hsa05168","Herpes simplex virus 1 infection","GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0006629,GO:0044255,GO:0046872","RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|lipid metabolic process|cellular lipid metabolic process|metal ion binding",null,null,"R-HSA-212436,R-HSA-73857,R-HSA-74160","Generic Transcription Pathway|RNA Polymerase II Transcription|Gene expression (Transcription)"]
["ZNF670-ZNF695",0,0,0,0.0231032880124957,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,100533111,"ZNF670-ZNF695 readthrough (NMD candidate)","non_coding"]
["ZNF671",2.43323195791349,2.34895068788808,2.79583926574912,2.8821838139644,2.23570247987099,2.37018734561758,2.87161263879895,2.73323895262769,2.74887296279302,3.1130263936081,3.39831703683937,2.78600829444516,2.60754689994738,2.8824241142427,2.59219357324306,2.59976193925172,2.66238271069089,2.83943184937814,3.02083639134803,3.15180944292787,3.02501263613355,2.84794513784075,3.25363890894732,2.82070865407225,2.70040596638698,2.94177139470488,3.08381511371683,3.55077665311708,79891,"zinc finger protein 671","protein_coding","hsa05168","Herpes simplex virus 1 infection","GO:0000978,GO:0003700,GO:0005634,GO:0006357,GO:0046872","RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity|nucleus|regulation of transcription by RNA polymerase II|metal ion binding",null,null,"R-HSA-212436,R-HSA-73857,R-HSA-74160","Generic Transcription Pathway|RNA Polymerase II Transcription|Gene expression (Transcription)"]
["ZNF672",7.87475009003331,8.25518559507909,9.13557807356066,9.41711986450061,6.90897805124848,8.16663857704021,8.29534584084497,8.71861629631411,7.09416726057722,10.0103781787106,9.35069090754849,7.86040980980122,6.77439608862305,7.44020172633264,7.07689193252887,6.82120970891068,7.91098724380158,8.23482886112071,8.16019524833007,8.61789232764871,7.55772427447412,8.67817410334766,6.15123335958862,6.67453420694506,7.19384903055806,7.7259648374679,6.8932910564999,8.79906130218143,79894,"zinc finger protein 672","protein_coding",null,null,"GO:0000981,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0043565,GO:0046872","DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|sequence-specific DNA binding|metal ion binding"]
["ZNF674",0.60728944667904,0.666046238112229,0.453788932464756,0.522994707394594,0.847739548242271,0.66920112160005,0.502998107645669,0.516510425908785,0.885110431410709,0.376005584298859,0.472048672022448,0.610983640752479,0.701282638933783,0.762121651430098,0.714614262721086,0.581678181141964,0.661324427173605,0.470164183626406,0.389452554739488,0.703162494892373,0.579040076292776,0.671496063409549,0.819763291453125,0.659900640019892,0.964558110597597,0.51815316401209,0.749569953877695,0.617528251331283,641339,"zinc finger protein 674","protein_coding","hsa05168","Herpes simplex virus 1 infection","GO:0000122,GO:0000977,GO:0001227,GO:0005634,GO:0046872","negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|nucleus|metal ion binding"]
["ZNF674-AS1",0.865911941914234,0.596830378493308,0.801167252919083,0.974887766370859,0.748030357562139,0.707074296565513,0.88984767646813,0.898334350680987,0.807874813467954,0.713116913557849,0.731725905490345,0.744921480822806,0.537048638449243,0.610182496678963,0.922002430558438,0.666331870502898,0.989373828463205,0.928925011933899,1.3686192103994,0.627526419312624,0.592240922228236,0.882724781973987,1.46191006386673,1.27508862327661,0.758950689271229,1.04933252488481,1.26296255915929,1.4275499591029,401588,"ZNF674 antisense RNA 1 (head to head)","non_coding"]
["ZNF675",1.84296062620874,1.26479488050552,0.657052177286453,0.917313501276758,1.80086354548715,1.02961766456177,0.729140484903934,0.85784878689002,1.54871804083358,0.887503650891891,0.921446996687888,1.58426047135657,1.73045390798288,0.822916216662972,0.770189608748508,0.75204842008048,1.592462600197,1.15480532801189,1.63862110363319,1.37964742276131,2.11380036505132,1.685277874416,2.52183747942294,1.91447916715245,1.48022599194862,1.18590137184526,1.96399653168334,1.5132802481739,171392,"zinc finger protein 675","protein_coding","hsa05168","Herpes simplex virus 1 infection","GO:0000122,GO:0000978,GO:0000981,GO:0003677,GO:0005515,GO:0005634,GO:0006355,GO:0007249,GO:0008270,GO:0010804,GO:0019221,GO:0031625,GO:0032088,GO:0043508,GO:0045453,GO:0045671,GO:0046329,GO:0048471,GO:2000660,GO:2000678","negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA binding|protein binding|nucleus|regulation of DNA-templated transcription|canonical NF-kappaB signal transduction|zinc ion binding|negative regulation of tumor necrosis factor-mediated signaling pathway|cytokine-mediated signaling pathway|ubiquitin protein ligase binding|negative regulation of NF-kappaB transcription factor activity|negative regulation of JUN kinase activity|bone resorption|negative regulation of osteoclast differentiation|negative regulation of JNK cascade|perinuclear region of cytoplasm|negative regulation of interleukin-1-mediated signaling pathway|negative regulation of transcription regulatory region DNA binding",null,null,"R-HSA-212436,R-HSA-73857,R-HSA-74160","Generic Transcription Pathway|RNA Polymerase II Transcription|Gene expression (Transcription)"]
["ZNF676",0,0.01740653975565,0.00859044796169378,0,0.0357643975836861,0.0515545006457136,0.0682957376300976,0.0538353984114823,0,0.0088127258467227,0,0,0,0.00872350680128864,0.0510572899749806,0.0260270740805976,0.00879727362251819,0,0,0,0,0,0,0.00893940402500835,0.0362865142077527,8.69424745206363E-3,0.00885439049387094,0,163223,"zinc finger protein 676","protein_coding","hsa05168","Herpes simplex virus 1 infection","GO:0000978,GO:0000981,GO:0005634,GO:0006355,GO:0006357,GO:0046872","RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of DNA-templated transcription|regulation of transcription by RNA polymerase II|metal ion binding",null,null,"R-HSA-212436,R-HSA-73857,R-HSA-74160","Generic Transcription Pathway|RNA Polymerase II Transcription|Gene expression (Transcription)"]
["ZNF677",2.24412116622999,1.8618060596734,1.54694584152738,1.36027611900434,2.06211095005707,1.57243054883929,1.86546596439288,1.4658025276464,1.98809988466436,1.31818181014201,1.43813711621162,1.84621929714872,2.13777500284819,1.76408088238726,1.89502850068392,1.62391814816647,1.28278996796008,1.21683775070575,1.40273196419231,1.79403972529143,1.32427455636725,1.32638629667872,2.0984421567265,1.66580995304536,1.5767419329213,1.23870646303769,1.61667281670549,1.17886303963237,342926,"zinc finger protein 677","protein_coding","hsa05168","Herpes simplex virus 1 infection","GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872","RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding",null,null,"R-HSA-212436,R-HSA-73857,R-HSA-74160","Generic Transcription Pathway|RNA Polymerase II Transcription|Gene expression (Transcription)"]
["ZNF678",0.515027271168957,0.385963211881592,0.278393778489953,0.281396763881702,0.58256501328086,0.307768906992793,0.180557449479107,0.318324546605365,0.552584127275961,0.237496634693279,0.305289398988665,0.427089641213769,0.644143284337933,0.348174591394369,0.357052213230547,0.366982950051669,0.318107621323007,0.340795867914563,0.409647786050496,0.468246902043833,0.436025377813907,0.347137158886393,0.739556798231857,0.344593529541133,0.405393390520529,0.308450476071452,0.447033938218119,0.278773311655742,339500,"zinc finger protein 678","protein_coding",null,null,"GO:0000978,GO:0000981,GO:0005634,GO:0006355,GO:0006357,GO:0046872","RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of DNA-templated transcription|regulation of transcription by RNA polymerase II|metal ion binding"]
["ZNF680",0.936889886620191,0.701828673713492,0.574237335060127,0.521427855218813,0.692546354722886,0.51055017099029,0.398557837860786,0.652142219511108,0.756837071166544,0.388055123102636,0.32869707638276,0.634904553974368,0.909439756894684,0.481315128364131,0.735866754649312,0.616756820478603,0.639401625895117,0.664750983688624,0.713352770324379,0.732883470969649,1.2004285152095,0.682907556881009,1.3706017601039,0.957998887097112,0.832600047636179,0.793351254264373,0.887821267899221,0.707366107492665,340252,"zinc finger protein 680","protein_coding","hsa05168","Herpes simplex virus 1 infection","GO:0000978,GO:0000981,GO:0005634,GO:0006355,GO:0006357,GO:0046872","RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of DNA-templated transcription|regulation of transcription by RNA polymerase II|metal ion binding",null,null,"R-HSA-212436,R-HSA-73857,R-HSA-74160","Generic Transcription Pathway|RNA Polymerase II Transcription|Gene expression (Transcription)","zf-C2H2"]
["ZNF681",0.323623947721866,0.248623900690252,0.179181644755563,0.167124569803182,0.304068941285033,0.120780522445498,0.181937132979424,0.15053527519492,0.396468885726755,0.211790270625764,0.0975479529629843,0.317244052408442,0.264360959249778,0.106800858548268,0.204504210715549,0.129818895283338,0.303166750036529,0.261048374140205,0.138046225117936,0.243377214541902,0.234963860417962,0.220852864677849,0.294912075243819,0.304011285104755,0.238579502449218,0.220769919601608,0.252940921483986,0.257437193011014,148213,"zinc finger protein 681","protein_coding","hsa05168","Herpes simplex virus 1 infection","GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872","RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding",null,null,"R-HSA-212436,R-HSA-73857,R-HSA-74160","Generic Transcription Pathway|RNA Polymerase II Transcription|Gene expression (Transcription)"]
["ZNF682",0.595920697067328,0.482846201185863,0.366074062184209,0.50802011697346,0.438528713985664,0.442153009904722,0.295154457270248,0.375143393079139,0.629016202591852,0.581033790459742,0.601942220358562,0.547733139755322,0.356820743843023,0.301603819479706,0.410520677582677,0.425511405997806,0.565868298950624,0.721564813445707,0.707152002649564,0.672095655887502,0.624956414220319,0.475533726816979,0.559252823910383,0.59657346981086,0.824215884738841,0.482345648627397,0.605138625428554,0.574067353812618,91120,"zinc finger protein 682","protein_coding","hsa05168","Herpes simplex virus 1 infection","GO:0000978,GO:0000981,GO:0005634,GO:0006355,GO:0006357,GO:0046872","RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of DNA-templated transcription|regulation of transcription by RNA polymerase II|metal ion binding",null,null,"R-HSA-212436,R-HSA-73857,R-HSA-74160","Generic Transcription Pathway|RNA Polymerase II Transcription|Gene expression (Transcription)"]
["ZNF683",0,0,0,0,0,0,0,0,0,0,0,0.0120000850518028,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,257101,"zinc finger protein 683","protein_coding",null,null,"GO:0000978,GO:0002250,GO:0003700,GO:0005515,GO:0005634,GO:0006357,GO:0010468,GO:0032823,GO:0032826,GO:0033082,GO:0045087,GO:0046872,GO:0051136,GO:1990841","RNA polymerase II cis-regulatory region sequence-specific DNA binding|adaptive immune response|DNA-binding transcription factor activity|protein binding|nucleus|regulation of transcription by RNA polymerase II|regulation of gene expression|regulation of natural killer cell differentiation|regulation of natural killer cell differentiation involved in immune response|regulation of extrathymic T cell differentiation|innate immune response|metal ion binding|regulation of NK T cell differentiation|promoter-specific chromatin binding"]
["ZNF684",1.014696561604,1.02864114802668,0.789682991973473,0.755474085127778,0.834963172117202,0.677026265537617,0.311415371251652,0.890270570660016,1.11465417010525,0.784398073804432,0.489687824975133,0.899976660992561,0.736422514694409,0.941931340618192,0.881579091539277,0.911450344623366,0.718840521618901,0.815328387146143,0.974822789647066,0.975753732807056,1.13414576607392,0.583780238124879,1.33124497164966,1.25220727525347,1.04570401159325,1.23055252124646,1.31781748800607,1.09200130232753,127396,"zinc finger protein 684","protein_coding","hsa05168","Herpes simplex virus 1 infection","GO:0000122,GO:0000977,GO:0001227,GO:0005634,GO:0046872,GO:1990837","negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|nucleus|metal ion binding|sequence-specific double-stranded DNA binding",null,null,"R-HSA-212436,R-HSA-73857,R-HSA-74160","Generic Transcription Pathway|RNA Polymerase II Transcription|Gene expression (Transcription)"]
["ZNF687",4.24062765281534,4.89591063935645,4.99107521888753,4.2448662518186,4.03503436447418,4.76776274187431,4.74468479463962,4.25937507621462,4.58468339096195,5.22738669677941,4.94535580682494,4.60226469361757,4.53836888855062,5.02123504430058,4.60680224919951,4.76317340540774,4.22767031862077,4.28595008487355,4.52488131960108,4.30376574115431,4.04920035005365,4.0974665042898,4.04810582414938,3.87724680326259,3.783422474113,3.98236940753305,3.87227769415845,4.10291040691841,57592,"zinc finger protein 687","protein_coding",null,null,"GO:0003677,GO:0003700,GO:0005515,GO:0005654,GO:0005829,GO:0006355,GO:0046872","DNA binding|DNA-binding transcription factor activity|protein binding|nucleoplasm|cytosol|regulation of DNA-templated transcription|metal ion binding"]
["ZNF687-AS1",0.303365766313025,0.288551175917215,0.366185108129178,0.207818161462884,0.127044110066164,0.162786236765565,0.161735725931083,0.467467824470122,0.741066034178954,0.125220049892821,0.24454111269473,0.218007976021498,0.0412140219860298,0.371857008568114,0.24182439914195,0.0821819509554563,0.708336105406681,0.280693659152695,0.400538730167574,0.62512061681464,0.081809228356672,0.370749011148021,0.470625251908048,0.21170003422568,0.472628930633614,0.205894316670252,0.503248251992484,0.8148540597255,100507670,"ZNF687 antisense RNA 1","non_coding"]
["ZNF688",4.32446516752623,3.57866606115054,5.13687586152616,4.69746866175091,3.86700646512032,4.13629437010443,4.41996209484386,4.51051294835539,3.40370980254058,4.98255018950839,5.18881554455565,3.73912437375833,3.27256872450773,3.99161686313092,4.17107641986671,3.68696208820544,4.69810349241099,4.40458688371338,6.05345261633089,4.84238823790559,4.78538729717653,4.83018472935189,5.60544714932182,5.24468367344328,4.27600283424157,5.27524019105925,5.33910703998637,6.33009840771523,146542,"zinc finger protein 688","protein_coding","hsa05168","Herpes simplex virus 1 infection","GO:0003674,GO:0003677,GO:0003700,GO:0005515,GO:0005575,GO:0005634,GO:0006355,GO:0008150,GO:0046872","molecular_function|DNA binding|DNA-binding transcription factor activity|protein binding|cellular_component|nucleus|regulation of DNA-templated transcription|biological_process|metal ion binding",null,null,"R-HSA-212436,R-HSA-73857,R-HSA-74160","Generic Transcription Pathway|RNA Polymerase II Transcription|Gene expression (Transcription)"]
["ZNF689",3.50120085428235,3.24372360894929,3.55741631925075,3.1761532606057,3.45825235004771,3.57246455669293,3.57062193366689,3.25491512836001,3.4607510502857,3.38670304183933,3.72029737766731,3.38525874174332,2.87557310892575,3.35964147653002,3.19971457337161,2.98914031116477,3.43905384857886,3.3867895596051,3.13782739369062,3.432416570954,3.14009899868093,3.35683448534271,3.29934438747876,3.25769273921192,3.24577105775998,3.41318018528295,3.19004497098694,3.50526987311549,115509,"zinc finger protein 689","protein_coding","hsa05168","Herpes simplex virus 1 infection","GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0035914,GO:0046872","RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|skeletal muscle cell differentiation|metal ion binding",null,null,"R-HSA-212436,R-HSA-73857,R-HSA-74160","Generic Transcription Pathway|RNA Polymerase II Transcription|Gene expression (Transcription)"]
["ZNF69",0.946954629673862,1.05285808672977,1.05122369965611,1.01863948765087,1.18791620599884,1.0214227792304,0.847682545522015,0.959951729139755,1.40301852767385,1.03528715354065,1.30574777058543,1.44194708203765,1.47251351659747,0.982105771870878,1.02347264490079,1.1890536440638,1.62402724335907,1.0952297093588,0.928417022449188,1.21209794541918,1.50977154159298,1.18596269647238,1.33279673976471,1.4439821655644,1.5160881162232,1.02136874031686,1.08971423059817,1.30529446780666,7620,"zinc finger protein 69","protein_coding",null,null,"GO:0000122,GO:0000977,GO:0001227,GO:0005515,GO:0005634,GO:0046872","negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleus|metal ion binding"]
["ZNF691",1.73515299628678,1.5503930263893,1.89230030230314,2.42052757944182,1.76402426430405,1.73637770526546,1.65158676437622,2.11396698066622,1.58666245671758,2.14383021699904,2.25816280636852,2.2041768706985,1.71678643209167,2.00515872847305,1.65443214033688,1.66180668056871,1.91258334098506,2.29469543219451,2.08152529818619,2.32587140289993,1.91895300532854,1.83258541704577,1.98982292640872,1.83218258489673,2.09386517200142,2.56465602148376,2.29812884298757,2.78464983908404,51058,"zinc finger protein 691","protein_coding",null,null,"GO:0000978,GO:0003700,GO:0005515,GO:0005634,GO:0006357,GO:0046872","RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding",null,null,"R-HSA-212436,R-HSA-73857,R-HSA-74160","Generic Transcription Pathway|RNA Polymerase II Transcription|Gene expression (Transcription)"]
["ZNF692",3.73659509668968,4.94636914346087,4.9676025438709,5.77214417784843,3.54463779066899,3.72228710969031,4.2750598019126,4.49319495193897,4.14258927063718,5.35007062409981,5.09580241536193,4.64656244393719,3.36325879652472,4.18645357527016,3.66947795950372,3.19805587965986,4.02081393669199,4.82849895157641,3.83155484367249,4.70349325977255,4.34198685651806,4.57150133521163,4.44276586877109,3.96142528800096,4.07410050817283,4.71663950576849,4.18768174434848,5.13676853819065,55657,"zinc finger protein 692","protein_coding",null,null,"GO:0000122,GO:0000978,GO:0001227,GO:0003700,GO:0005515,GO:0005654,GO:0005730,GO:0006111,GO:0006357,GO:0046872","negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleoplasm|nucleolus|regulation of gluconeogenesis|regulation of transcription by RNA polymerase II|metal ion binding",null,null,"R-HSA-212436,R-HSA-73857,R-HSA-74160","Generic Transcription Pathway|RNA Polymerase II Transcription|Gene expression (Transcription)"]
["ZNF695",0.0941765111685462,0.0895774871757438,0.0476087658871403,0.152850509081327,0.10618306431222,0.0204084330693727,0.00675891034191977,0.0497264886697836,0.204031270076998,0.104658520603782,0.0272515582005056,0.0437304900033448,0.117118266186584,0.0207197939021201,0.0741092241749182,0.0137374827987889,0.0557200066475433,0.174276417853011,0.0736491801076738,0.0975284481093235,0.129914197892925,0.137720376800781,0.00715176532913455,0.113240459049393,0.150826490726742,0.0894846248103018,0.0701022155198704,0.0885368170779413,57116,"zinc finger protein 695","protein_coding",null,null,"GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006355,GO:0006357,GO:0046872","RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of DNA-templated transcription|regulation of transcription by RNA polymerase II|metal ion binding"]
["ZNF696",1.01273887208405,1.11190345172491,1.51040656832367,1.22658222889699,0.983950904840482,1.40206548578739,1.43081256468551,1.2654785912985,1.3039078676797,1.61079903596922,1.54564542991622,1.49632662082183,1.30982373523484,1.10897158831169,1.37777954501828,1.0260746504329,1.14616879066967,1.23155354469682,1.53503157743955,1.30220488816569,1.30545258362453,1.40821302760177,1.55968210167255,1.24949377864879,1.77287043229477,1.38019031804178,1.31041177510022,1.5342277961796,79943,"zinc finger protein 696","protein_coding",null,null,"GO:0000977,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872","RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding",null,null,"R-HSA-212436,R-HSA-73857,R-HSA-74160","Generic Transcription Pathway|RNA Polymerase II Transcription|Gene expression (Transcription)"]
["ZNF697",2.19421911336409,2.16995700646959,1.93728735456464,1.72828119230851,1.970745904123,1.81790181343981,1.71905599657219,1.57787257597962,2.11316839143716,1.21403158867339,1.27617275591558,1.70342738322231,1.92093222113804,1.64683008028068,1.77431893644378,1.87683421904923,1.49617642835345,1.29013430129898,1.33182711864725,1.37674256924146,1.34248934287596,1.3076216646892,1.48406190687331,1.37135473966184,1.23735505176284,1.16222242541915,1.21374770363264,1.04457685820509,90874,"zinc finger protein 697","protein_coding",null,null,"GO:0000978,GO:0000981,GO:0003674,GO:0005515,GO:0005575,GO:0005634,GO:0006357,GO:0008150,GO:0046872","RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|molecular_function|protein binding|cellular_component|nucleus|regulation of transcription by RNA polymerase II|biological_process|metal ion binding",null,null,"R-HSA-212436,R-HSA-73857,R-HSA-74160","Generic Transcription Pathway|RNA Polymerase II Transcription|Gene expression (Transcription)"]
["ZNF699",0.745902966704714,0.796739411455346,0.748962997784844,0.562345243421052,0.779534738691472,0.707932244069484,0.53961767985071,0.531949180870841,0.862618254188948,0.560889966009023,0.532673602585808,0.533735656240143,0.967291510388309,0.585634131345936,0.819810238602416,0.941711763841311,0.64427597505855,0.501932905234955,0.446069042762237,0.763304525087132,0.579782655062807,0.599055108670923,0.681241099529413,0.70534516878353,0.779051271035801,0.413116983770636,0.706357101845918,0.61498692604675,374879,"zinc finger protein 699","protein_coding","hsa05168","Herpes simplex virus 1 infection","GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872","RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding",null,null,"R-HSA-212436,R-HSA-73857,R-HSA-74160","Generic Transcription Pathway|RNA Polymerase II Transcription|Gene expression (Transcription)"]
["ZNF7",2.73377769829526,2.96747443409665,2.7267154742318,3.08681088227304,2.95206365464096,2.58401802961678,2.64272944150222,2.95364932490347,3.17424676006557,2.82320992421692,2.72715941088245,2.98073719621466,2.62114316546889,2.8502638451912,2.91812180433358,2.6260862652772,3.05994813941456,2.87420691202901,3.12404201321675,3.00872652223278,2.69467745745817,2.75216570973216,3.32369510279471,3.36813520564431,3.18207954463231,3.0923577719384,3.22316328410462,3.03428312141814,7553,"zinc finger protein 7","protein_coding","hsa05168","Herpes simplex virus 1 infection","GO:0000978,GO:0000981,GO:0003677,GO:0005634,GO:0006357,GO:0046872","RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding"]
["ZNF70",1.45350280657442,1.38613204210444,1.22208344015717,1.13557718389787,1.2571339321569,1.22592726693842,1.09408992863939,1.27644389028199,1.59181507026138,1.79831716872687,1.48471307879268,1.55016162749995,1.48332183704809,1.36764641585716,1.35527885133644,1.40692769507735,1.1602889276695,1.37296633803129,1.0978358893623,1.19335288128393,1.27876012906606,1.18320475320873,1.09024499053998,1.09375867323863,1.32439901947507,1.02770337930834,0.984202339552997,1.17380054254615,7621,"zinc finger protein 70","protein_coding",null,null,"GO:0000977,GO:0000981,GO:0005515,GO:0005737,GO:0006357,GO:0043076,GO:0046872","RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|cytoplasm|regulation of transcription by RNA polymerase II|megasporocyte nucleus|metal ion binding",null,null,"R-HSA-212436,R-HSA-73857,R-HSA-74160","Generic Transcription Pathway|RNA Polymerase II Transcription|Gene expression (Transcription)"]
["ZNF700",3.45931794393372,3.8567631075635,4.44566525500353,3.90689399448056,4.00833373353682,3.26622707316714,3.65961105667869,4.05951371373652,4.00249636668115,3.26804426145013,3.88439095406763,3.94631127983375,3.22686138900297,3.37913539225933,2.82159555759,2.98422489018229,5.05249756631061,4.05782586559512,3.94842429012035,4.27180367273473,4.83517782267088,4.49208907850376,5.46790575412688,4.80170119705146,5.14447220371368,4.98434621723267,5.5334662724197,4.44284033265481,90592,"zinc finger protein 700","protein_coding","hsa05168","Herpes simplex virus 1 infection","GO:0000977,GO:0000981,GO:0005634,GO:0006357,GO:0046872","RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding",null,null,"R-HSA-212436,R-HSA-73857,R-HSA-74160","Generic Transcription Pathway|RNA Polymerase II Transcription|Gene expression (Transcription)"]
["ZNF701",1.23076721306839,1.30379813591058,0.956109936558035,1.04613839187683,1.29226341929909,1.07417055982806,0.711492399355557,0.941844752620864,1.34964636754002,0.832094891970576,0.980441288354592,1.05372993932052,1.24847862053437,1.04914500203114,1.12665200963412,1.04339440973133,1.05337625011102,0.848506884222164,1.01259920263707,1.13711883970615,1.33932766079927,0.917560469249255,1.48187010628463,1.21657205702418,1.20107062600115,1.05021216393473,1.20967303639936,1.05723849113498,55762,"zinc finger protein 701","protein_coding","hsa05168","Herpes simplex virus 1 infection","GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872","RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding",null,null,"R-HSA-212436,R-HSA-73857,R-HSA-74160","Generic Transcription Pathway|RNA Polymerase II Transcription|Gene expression (Transcription)"]
["ZNF703",13.9739849183905,15.7736005556537,14.5846065975366,16.3722607058395,12.5347634434762,14.3055032862313,13.2727184616996,14.2050445913472,14.6937256554136,19.8396995575463,21.1307316683595,16.479851422619,14.0390171780349,17.8718136581396,15.6417456822959,15.0607595005805,13.9822370676954,18.2699744359357,14.410165950995,15.8062765950523,15.6369606449243,18.8926212526403,10.7056793924827,12.3020703001019,13.7654795704248,17.9586288330932,11.0051155363469,16.9430422520493,80139,"zinc finger protein 703","protein_coding",null,null,"GO:0005515,GO:0005634,GO:0005737,GO:0006355,GO:0008284,GO:0010718,GO:0016363,GO:0017015,GO:0030335,GO:0032991,GO:0033601,GO:0034111,GO:0034333,GO:0045892,GO:0046872,GO:0051726,GO:0060644,GO:0060828,GO:0071392,GO:0140297","protein binding|nucleus|cytoplasm|regulation of DNA-templated transcription|positive regulation of cell population proliferation|positive regulation of epithelial to mesenchymal transition|nuclear matrix|regulation of transforming growth factor beta receptor signaling pathway|positive regulation of cell migration|protein-containing complex|positive regulation of mammary gland epithelial cell proliferation|negative regulation of homotypic cell-cell adhesion|adherens junction assembly|negative regulation of DNA-templated transcription|metal ion binding|regulation of cell cycle|mammary gland epithelial cell differentiation|regulation of canonical Wnt signaling pathway|cellular response to estradiol stimulus|DNA-binding transcription factor binding",null,null,"R-HSA-212436,R-HSA-73857,R-HSA-74160","Generic Transcription Pathway|RNA Polymerase II Transcription|Gene expression (Transcription)"]
["ZNF704",1.73140312385144E-3,0,1.62550322404456E-3,0,0,0.00162587576703997,1.61538347885435E-3,1.69780850536565E-3,0.00348311367808057,0.00833781564148149,0.0048848536224588,0.0104516123901629,1.64654901890362E-3,0.00330136181342364,0.0225427330777838,0.0032832663301621,0.00332927844973198,0,0.0128015975419991,3.32990792522496E-3,4.9025634309702E-3,0.00822881241691356,6.83710419158832E-3,0.00507460034511039,0.00343310652116511,0,0.00502634101000908,0.00976631559796892,619279,"zinc finger protein 704","protein_coding",null,null,"GO:0000978,GO:0003700,GO:0005515,GO:0005634,GO:0006357,GO:0046872,GO:1990837","RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding|sequence-specific double-stranded DNA binding",null,null,"R-HSA-212436,R-HSA-73857,R-HSA-74160","Generic Transcription Pathway|RNA Polymerase II Transcription|Gene expression (Transcription)"]
["ZNF705A",0,0,0,0,0,0,0,0,0.030715716145022,0,0,0,0,0,0,0,0,0.0423817104000428,0,0,0,0,0,0,0.00756868244520245,0,0,0,440077,"zinc finger protein 705A","protein_coding","hsa05168","Herpes simplex virus 1 infection","GO:0000122,GO:0000785,GO:0000977,GO:0000981,GO:0001227,GO:0005634,GO:0046872","negative regulation of transcription by RNA polymerase II|chromatin|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|nucleus|metal ion binding",null,null,"R-HSA-212436,R-HSA-73857,R-HSA-74160","Generic Transcription Pathway|RNA Polymerase II Transcription|Gene expression (Transcription)"]
["ZNF706",6.76152802351381,6.74282413013818,8.38558276225666,7.03894667076663,6.51296260494508,6.64488144792377,7.78221226574231,6.63662991270125,6.82701606416346,6.20299600178142,6.62453214187097,6.52486758914842,7.14461466415278,5.85247146045405,7.97219812273707,7.0380481847789,6.55018841008738,7.08798771522564,9.38855913863301,7.73698196989613,8.0667445915172,7.83701117609826,8.48811135288738,7.77894246772665,6.37886320853689,7.36426783313287,8.65565814963237,7.9321908271335,51123,"zinc finger protein 706","protein_coding",null,null,"GO:0005634,GO:0005737,GO:0006417,GO:0045892,GO:0046872,GO:1902455","nucleus|cytoplasm|regulation of translation|negative regulation of DNA-templated transcription|metal ion binding|negative regulation of stem cell population maintenance",null,null,"R-HSA-212436,R-HSA-73857,R-HSA-74160","Generic Transcription Pathway|RNA Polymerase II Transcription|Gene expression (Transcription)","other"]
["ZNF707",2.42341409522286,3.18976080804321,3.02824304044528,3.67451981620964,3.12683746680731,2.71642769166773,2.953660936001,3.60642635240148,2.85820239828966,3.44355797857628,3.64331939071644,3.31383165425473,2.42636954128454,3.28666610281257,2.67435789816085,3.02592954841182,2.64172185046034,3.17395944960776,2.92589801997245,2.4945195144507,3.05247608014326,3.43909448179963,2.80522391800358,2.71774861285277,3.07096594814358,3.10537381975863,2.76621922200258,3.66612101761969,286075,"zinc finger protein 707","protein_coding","hsa05168","Herpes simplex virus 1 infection","GO:0000978,GO:0003700,GO:0005515,GO:0005634,GO:0006357,GO:0046872","RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding",null,null,"R-HSA-212436,R-HSA-73857,R-HSA-74160","Generic Transcription Pathway|RNA Polymerase II Transcription|Gene expression (Transcription)"]
["ZNF708",0.595863130200014,0.847639238488313,0.435652670808526,0.551238486340399,0.752290670535248,0.708097839170087,0.536255807251349,0.424006418396538,0.922904523924328,0.639915607081392,0.525661340707777,0.503994182437805,1.03302720366079,0.613328056820178,0.681652774550559,1.08993973217488,0.795957079505938,0.44399235678965,0.711536055633368,0.938088541690932,0.771442459494009,0.701721959023858,1.74392132131313,0.947912578914735,0.941021750493305,0.736531336088728,0.989925014205613,0.718815411254331,7562,"zinc finger protein 708","protein_coding","hsa05168","Herpes simplex virus 1 infection","GO:0000978,GO:0000981,GO:0005634,GO:0006355,GO:0006357,GO:0046872","RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of DNA-templated transcription|regulation of transcription by RNA polymerase II|metal ion binding",null,null,"R-HSA-212436,R-HSA-73857,R-HSA-74160","Generic Transcription Pathway|RNA Polymerase II Transcription|Gene expression (Transcription)","zf-C2H2"]
["ZNF709",0.467894281191681,0.382215195708657,0.501291319262719,0.438179309931911,0.360386375529055,0.367008667962062,0.395454914117996,0.464213504864867,0.498322821815731,0.413530456783074,0.641922501528798,0.531659884181976,0.355970650177888,0.430335916888074,0.363469100636675,0.427977151984081,0.264618828792511,0.397273361750697,0.488400421804496,0.561097985267482,0.467600633388452,0.601721615669864,0.717326297782658,0.387207446712797,0.371105003992785,0.418431741781163,0.362218161906509,0.476099741818787,163051,"zinc finger protein 709","protein_coding","hsa05168","Herpes simplex virus 1 infection","GO:0000977,GO:0000981,GO:0005634,GO:0006357,GO:0046872","RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding",null,null,"R-HSA-212436,R-HSA-73857,R-HSA-74160","Generic Transcription Pathway|RNA Polymerase II Transcription|Gene expression (Transcription)"]
["ZNF71",3.10625302036247,2.51498081449278,2.89492301740472,2.94274722057982,2.56889998613646,3.00941790405008,2.50933569722052,2.34020570413488,3.32260655260818,3.70681379847613,3.41287661767109,4.09318246783837,2.99724862757987,3.10589205894784,4.07250050037087,3.4839557538972,3.17586028332918,3.42088775895657,3.65510166008231,3.09632068680813,3.52536152876054,3.35589102427319,3.0964731812647,2.84227823354329,2.83925146034168,3.44821477909509,2.95454436794894,3.19089337924211,58491,"ZNF71-SMIM17 readthrough (NMD candidate)","protein_coding",null,null,"GO:0000978,GO:0001228,GO:0005515,GO:0005634,GO:0006357,GO:0045944,GO:0046872","RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase II|metal ion binding",null,null,"R-HSA-212436,R-HSA-73857,R-HSA-74160","Generic Transcription Pathway|RNA Polymerase II Transcription|Gene expression (Transcription)"]
["ZNF710",3.00662296348906,3.05648209384417,2.62470738783696,2.67727692820472,2.80458611557948,2.79230343793427,2.29582597460243,2.74145905172531,2.48346673226908,3.60875039154146,2.85478050318486,3.18302348052499,2.48563929100894,2.92164670422183,2.60383562269306,2.78015311502411,2.17894889757323,2.32655953280431,2.21691243165471,2.47763107026055,2.43965461212459,2.27610390673393,2.36802652623989,2.19799070821954,2.38630873113742,2.15343090527633,2.08504187170385,2.34057389950794,374655,"zinc finger protein 710","protein_coding",null,null,"GO:0000978,GO:0003700,GO:0005515,GO:0005634,GO:0006357,GO:0046872","RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding",null,null,"R-HSA-212436,R-HSA-73857,R-HSA-74160","Generic Transcription Pathway|RNA Polymerase II Transcription|Gene expression (Transcription)"]
["ZNF710-AS1",1.2891102076632,1.64217547353154,1.6641113548476,1.05971289985241,1.46211026757046,0.907905134343216,1.11681902636954,1.60269498208598,2.26917271208179,1.64065711826553,1.97004213788031,2.40862509869832,1.24782402689385,2.65553678516495,1.96956439175903,2.20445538980515,1.35006221486614,1.40576260772678,1.27652480015831,1.2839084185713,0.977728566056042,1.3785151106221,0.93175104216746,0.742161383862734,0.981362734160908,1.09364871877794,1.35882758163242,1.42832574124044,109729181,"ZNF710 antisense RNA 1","non_coding"]
["ZNF711",0.660905944112685,0.841256466005625,0.743666113270133,0.484706732601804,0.835753429310931,0.730146308045296,0.57581358996755,0.528949531066197,1.52019953322564,0.9922490631012,0.882043819919223,1.20762348613978,1.55742491519373,0.972937573045832,1.28802990312762,1.35003892498901,0.995181468105808,0.633995088593826,0.781494604084663,0.990696532848335,0.940282558838945,0.785269323534077,1.21376687467037,1.07772758725295,1.0310354769782,0.683389479552796,0.846458660733709,0.593916524872939,7552,"zinc finger protein 711","protein_coding",null,null,"GO:0000785,GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0010468,GO:0043565,GO:0045893,GO:0045944,GO:0046872","chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|regulation of gene expression|sequence-specific DNA binding|positive regulation of DNA-templated transcription|positive regulation of transcription by RNA polymerase II|metal ion binding",null,null,"R-HSA-212436,R-HSA-73857,R-HSA-74160","Generic Transcription Pathway|RNA Polymerase II Transcription|Gene expression (Transcription)","zf-C2H2"]
["ZNF713",0.222676399373279,0.22945238397036,0.180020938630024,0.124576449060495,0.187369170131236,0.255572150516291,0.294319682078122,0.139505083584412,0.472851464078335,0.363400576184293,0.378109116806177,0.311154109879237,0.394114995926068,0.218191759603961,0.534976831603382,0.433991606078217,0.261665396063629,0.211757813929722,0.114334598515021,0.220078413268657,0.245202418723003,0.129349076246737,0.238149846901945,0.229634787010471,0.196236935945001,0.135177792303104,0.227450965352883,0.197711492141749,349075,"zinc finger protein 713","protein_coding","hsa05168","Herpes simplex virus 1 infection","GO:0000978,GO:0000981,GO:0005634,GO:0006355,GO:0006357,GO:0046872,GO:1990837","RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of DNA-templated transcription|regulation of transcription by RNA polymerase II|metal ion binding|sequence-specific double-stranded DNA binding",null,null,"R-HSA-212436,R-HSA-73857,R-HSA-74160","Generic Transcription Pathway|RNA Polymerase II Transcription|Gene expression (Transcription)"]
["ZNF714",1.21044248028456,0.922823059177656,0.44241788543852,0.534656861376015,1.06541699067827,0.618948537574007,0.327592460418226,0.425854486680225,0.579338871783867,0.344107138934601,0.133242122113452,0.343960390321669,0.483294684235174,0.229039897263998,0.226286702563931,0.347517347224689,0.607054097217482,0.470220524922321,0.344439509939122,0.654557664751479,0.569785571721812,0.483063820512408,0.71455140717342,0.722179641435318,0.937452061037594,0.482882397620385,0.673585211752433,0.376423099116795,148206,"zinc finger protein 714","protein_coding","hsa05168","Herpes simplex virus 1 infection","GO:0000978,GO:0000981,GO:0005634,GO:0006355,GO:0006357,GO:0046872","RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of DNA-templated transcription|regulation of transcription by RNA polymerase II|metal ion binding",null,null,"R-HSA-212436,R-HSA-73857,R-HSA-74160","Generic Transcription Pathway|RNA Polymerase II Transcription|Gene expression (Transcription)"]
["ZNF717",0.907308616318464,0.910139739510424,0.823181407139651,0.873817911094595,1.02441403982546,0.912866815633796,0.988781458955565,1.15511989981497,1.04683969319416,0.771048079809569,1.06121136426842,0.874473741407573,0.935350218106367,1.04673198961105,1.13805551269221,1.0120781062369,0.751370026707313,0.712517407329358,0.824460629308869,0.90914633354414,0.734026967028808,0.840688340556954,0.812916314322909,0.729989381205518,0.748345850286233,0.811394239938707,0.818961622921443,0.795632215974656,100131827,"zinc finger protein 717","protein_coding","hsa05168","Herpes simplex virus 1 infection","GO:0000978,GO:0001228,GO:0005634,GO:0006357,GO:0045944,GO:0046872","RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase II|metal ion binding",null,null,"R-HSA-212436,R-HSA-73857,R-HSA-74160","Generic Transcription Pathway|RNA Polymerase II Transcription|Gene expression (Transcription)"]
["ZNF718",0.598844708512704,0.503277307478599,0.396632432836341,0.413043339170449,0.472942255143854,0.481460358662609,0.260224218806341,0.438407895250171,0.470333235039573,0.505656293987974,0.374166755257756,0.383776304958599,0.491482856221718,0.348029692978861,0.415784403860467,0.396679222186394,0.729549923464491,0.554089917723992,0.492811346946897,0.579806030410122,0.894287397195934,0.651098647189922,0.741014080723808,0.645163263159709,0.524578101811818,0.685930086260679,0.563614559355146,0.451157861704683,255403,"zinc finger protein 718","protein_coding","hsa05168","Herpes simplex virus 1 infection","GO:0000978,GO:0000981,GO:0005634,GO:0006355,GO:0006357,GO:0046872","RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of DNA-templated transcription|regulation of transcription by RNA polymerase II|metal ion binding",null,null,"R-HSA-212436,R-HSA-73857,R-HSA-74160","Generic Transcription Pathway|RNA Polymerase II Transcription|Gene expression (Transcription)"]
["ZNF721",4.00910969152449,3.98890619188374,3.67724483907698,3.00958765922846,4.41920295210394,3.74850755262045,3.25070465459003,3.30344050547872,3.99200456190638,2.73901329762709,2.6202478180479,3.74331777873164,5.16761922065965,3.69570534915316,4.82820809756986,4.28802311358082,3.27217915134683,3.095687825989,3.54536347013083,3.23951514111826,3.25587773835162,3.47633285893429,4.16858081619248,3.92242607390145,3.83174874136242,2.75700112473166,3.50554282046323,2.8525297713301,170960,"zinc finger protein 721","protein_coding","hsa05168","Herpes simplex virus 1 infection","GO:0000978,GO:0001228,GO:0005634,GO:0006357,GO:0045944,GO:0046872","RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase II|metal ion binding",null,null,"R-HSA-212436,R-HSA-73857,R-HSA-74160","Generic Transcription Pathway|RNA Polymerase II Transcription|Gene expression (Transcription)"]
["ZNF724",0.412640898775768,0.332763224406931,0.0505307015543758,0.180666943429497,0.420746417097661,0.235863984984116,0.108801587344321,0.219909988519449,0.406037746827227,0.1727939457201,0.0506171620952153,0.24367560394709,0.358294545877884,0.128283449433925,0.100109668064088,0.153096359883076,0.310483744196269,0.315401727013696,0.240429870707577,0.258785373483332,0.457206050256888,0.28990941348709,0.247962770752702,0.438194413605234,0.47135638563811,0.281276987951654,0.269096860646674,0.269864479280804,440519,"zinc finger protein 724","protein_coding","hsa05168","Herpes simplex virus 1 infection","GO:0000978,GO:0000981,GO:0005634,GO:0006355,GO:0006357,GO:0046872","RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of DNA-templated transcription|regulation of transcription by RNA polymerase II|metal ion binding"]
["ZNF726",0.388774097610326,0.238461852155951,0.126213237460647,0.216047973545077,0.305335109658053,0.191069220886176,0.210175782949396,0.213774206389307,0.274103299909201,0.258958011253394,0.167433257687693,0.270507376204812,0.162400689950073,0.128168174734339,0.138540814730601,0.151580781355231,0.436662085387831,0.379890137816154,0.339164902366725,0.262046787746803,0.315504197565858,0.455886190281666,0.390979558980772,0.401120059457774,0.425064306544435,0.486786449942432,0.334017828213999,0.488462118859309,730087,"zinc finger protein 726","protein_coding","hsa05168","Herpes simplex virus 1 infection","GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872","RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding",null,null,"R-HSA-212436,R-HSA-73857,R-HSA-74160","Generic Transcription Pathway|RNA Polymerase II Transcription|Gene expression (Transcription)"]
["ZNF727",0.0528158723586588,0.0191377742564452,0.0165284771287599,0.0120603560766853,0.0491518544884957,0.0377880348080543,0.0234651104518412,0.0345273865161904,0.10372142521998,0.06055768413987,0.0354787675163561,0.0708495411530212,0.124372674670288,0.0503534681627657,0.079525135178422,0.0977702982490225,0.0265986610385635,0.0302520316678044,0.0418401905482008,0.0169296209840825,0.0569718306077813,0.0167344777688466,0.0372434952272481,0.0466854078089025,0.0448824705030955,0.0238974183558308,0.0194700760551922,0.0260087305310779,442319,"zinc finger protein 727","protein_coding","hsa05168","Herpes simplex virus 1 infection","GO:0000978,GO:0000981,GO:0005634,GO:0006355,GO:0006357,GO:0046872","RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of DNA-templated transcription|regulation of transcription by RNA polymerase II|metal ion binding",null,null,"R-HSA-212436,R-HSA-73857,R-HSA-74160","Generic Transcription Pathway|RNA Polymerase II Transcription|Gene expression (Transcription)"]
["ZNF728",0.124413301085737,0.0197229485077481,0.0292009150328652,0.0397731989015119,0.202619067849114,0.136302168245628,0.00967304053164748,0.0203332158615675,0.114714339498923,0.0798839702906002,0.0195005861661695,0.0312925294812396,0.157754594924988,0.0988440424484475,0,0.0294906770159387,0.029903963183006,0.0383717485698849,0.0287463565574113,0.0797589792120423,0.00978564231497116,0.0591297140856587,0.112588041033387,0.19245161572916,0.123346235603122,0,0.060196233219101,0.0292407245278419,388523,"zinc finger protein 728","protein_coding","hsa05168","Herpes simplex virus 1 infection","GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872","RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding"]
["ZNF729",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.00695239794849372,0,0,0,100287226,"zinc finger protein 729","protein_coding","hsa05168","Herpes simplex virus 1 infection","GO:0000978,GO:0001228,GO:0005634,GO:0006357,GO:0045944,GO:0046872","RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase II|metal ion binding",null,null,"R-HSA-212436,R-HSA-73857,R-HSA-74160","Generic Transcription Pathway|RNA Polymerase II Transcription|Gene expression (Transcription)"]
["ZNF730",0.270596787126739,0.302802870505728,0.224158190391053,0.106860380869134,0.171092569840114,0.194314955784818,0.0445525338924419,0.124868878039741,0.344232309525179,0.176301351615658,0.1796333889532,0.144128568026967,0.272472506734922,0.121402780214213,0.155433043085924,0.0830069247766802,0.267814255452568,0.147278633424418,0.18389067771201,0.27551817442601,0.240379521879421,0.226951958403768,0.455707023856852,0.256590192058831,0.299837813148029,0.166368929986167,0.354269731965578,0.261874415119931,100129543,"zinc finger protein 730","protein_coding","hsa05168","Herpes simplex virus 1 infection","GO:0000978,GO:0000981,GO:0005634,GO:0006355,GO:0006357,GO:0046872","RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of DNA-templated transcription|regulation of transcription by RNA polymerase II|metal ion binding",null,null,"R-HSA-212436,R-HSA-73857,R-HSA-74160","Generic Transcription Pathway|RNA Polymerase II Transcription|Gene expression (Transcription)"]
["ZNF732",0.218315468657126,0.295087592762983,0.183387389095288,0.30855593350704,0.269467814019282,0.183429418964096,0.117923682525625,0.202812127519471,0.115576719637758,0.199199158653031,0.151283319788697,0.219643500479289,0.174834589430933,0.153364157933652,0.0641154204033645,0.206996226852425,0.375605334665776,0.329578317853018,0.28672836463914,0.298331220198496,0.466340499068105,0.371346030489644,0.31761642204257,0.235739628905015,0.318968668368404,0.425795765881244,0.300211393292192,0.248450600563363,654254,"zinc finger protein 732","protein_coding","hsa05168","Herpes simplex virus 1 infection","GO:0000978,GO:0000981,GO:0005634,GO:0006355,GO:0006357,GO:0046872","RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of DNA-templated transcription|regulation of transcription by RNA polymerase II|metal ion binding",null,null,"R-HSA-212436,R-HSA-73857,R-HSA-74160","Generic Transcription Pathway|RNA Polymerase II Transcription|Gene expression (Transcription)"]
["ZNF736",0.957469076505907,0.971060329866874,0.760821244713503,0.771677503026553,1.08495606567328,0.855781545114618,0.656529037474822,0.687200480439626,1.14583800991464,0.872168521253424,0.68618196106271,1.14028410627048,1.2478849216076,0.923827489921512,0.970902410905426,1.01993718376867,0.881730207899483,0.733812994208508,0.687673620010395,0.920722569485329,0.732221914527744,0.904627058334139,0.854125990896854,0.980501607111453,1.00644123626099,0.72068958354167,0.767453135616726,0.832350712104542,728927,"zinc finger protein 736","protein_coding","hsa05168","Herpes simplex virus 1 infection","GO:0000978,GO:0000981,GO:0005634,GO:0006355,GO:0006357,GO:0046872","RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of DNA-templated transcription|regulation of transcription by RNA polymerase II|metal ion binding",null,null,"R-HSA-212436,R-HSA-73857,R-HSA-74160","Generic Transcription Pathway|RNA Polymerase II Transcription|Gene expression (Transcription)"]
["ZNF737",0.801351013167529,0.920524534743057,0.758124221373115,0.715335489047316,0.912550318154197,0.960896668106456,0.793662689859391,0.568195512985034,1.25557864886146,0.608537562384089,0.721740194601997,0.803124832405929,1.33363598928267,1.07840138696899,1.30132457551827,1.36179984269042,0.67858905706082,0.556096401924641,0.840325309838191,0.901004704567778,0.735993084242857,0.68554230600112,1.18057933802965,0.95152218447578,0.736419994177495,0.623784917410819,0.94545574013231,0.567919552534045,100129842,"zinc finger protein 737","protein_coding","hsa05168","Herpes simplex virus 1 infection","GO:0000978,GO:0000981,GO:0005634,GO:0006355,GO:0006357,GO:0046872","RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of DNA-templated transcription|regulation of transcription by RNA polymerase II|metal ion binding",null,null,"R-HSA-212436,R-HSA-73857,R-HSA-74160","Generic Transcription Pathway|RNA Polymerase II Transcription|Gene expression (Transcription)"]
["ZNF738",0.465410257680873,0.519670611083507,0.187261632060626,0.288329034395947,0.457604028836712,0.244310282416523,0.361403466083215,0.351497522454122,0.540832118758754,0.51228540733275,0.361571190148065,0.671824600766131,0.536069568545368,0.394104182116169,0.379061366461971,0.49061523085676,0.61699973366331,0.449350664217848,0.414111946117489,0.578199141526441,0.4965754362943,0.423155272920424,0.473731401511185,0.477286524348204,0.593252403946385,0.409262701991757,0.422395731221073,0.320681118325001,148203,"zinc finger protein 738","protein_coding","hsa05168","Herpes simplex virus 1 infection","GO:0000209,GO:0003677,GO:0004842,GO:0005634,GO:0006355,GO:0046872","protein polyubiquitination|DNA binding|ubiquitin-protein transferase activity|nucleus|regulation of DNA-templated transcription|metal ion binding"]
["ZNF74",2.53664897213698,3.18196902591669,3.57548981846861,3.42712397201361,2.68132566453661,3.47895057998367,3.40491026713991,3.0703155950967,3.57352548499675,4.80635221248444,3.7051113715722,3.26833085692947,2.95132554672165,3.61769195361317,3.85678913503315,3.51922079056868,2.62490343495275,3.36392329129324,3.05350187432057,2.61210656919438,2.46598186337273,3.3638237346508,3.30258253697935,3.20077424054814,2.48062984935168,2.65983781089248,3.13020412739325,3.56736839239672,7625,"zinc finger protein 74","protein_coding","hsa05168","Herpes simplex virus 1 infection","GO:0000978,GO:0000981,GO:0003723,GO:0005634,GO:0005654,GO:0006355,GO:0006357,GO:0015629,GO:0046872","RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|RNA binding|nucleus|nucleoplasm|regulation of DNA-templated transcription|regulation of transcription by RNA polymerase II|actin cytoskeleton|metal ion binding","WP4657","22q11.2 copy number variation syndrome","R-HSA-212436,R-HSA-73857,R-HSA-74160","Generic Transcription Pathway|RNA Polymerase II Transcription|Gene expression (Transcription)"]
["ZNF740",3.47951146211595,4.09090237593944,4.86393085216074,4.39039465619063,3.92612021677957,4.10235436432372,4.56670845277482,4.24161743343679,4.66655581236515,4.29050404231413,5.00245007141054,5.22470719726335,4.59922520812465,5.44375497876316,5.65929444294924,5.13096942344572,4.54918846443752,4.62852100702024,4.299158369417,4.42875340802772,4.29464836315796,4.4274177609143,4.47679450993289,4.48142056929842,4.36774998475943,3.98142553954891,4.66803628523988,3.8669484365702,283337,"zinc finger protein 740","protein_coding",null,null,"GO:0000785,GO:0000978,GO:0000981,GO:0003700,GO:0005515,GO:0005634,GO:0006357,GO:0046872,GO:1990837","chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding|sequence-specific double-stranded DNA binding",null,null,"R-HSA-212436,R-HSA-73857,R-HSA-74160","Generic Transcription Pathway|RNA Polymerase II Transcription|Gene expression (Transcription)"]
["ZNF746",7.61886614756985,9.39618252315988,9.58738853316031,8.63923801608998,7.9395488153061,8.98661308209352,8.62331845104863,8.8211507474565,7.48344700058564,8.30721933375853,8.41928651471129,7.50370870321251,7.43336327094438,8.50565889781991,7.75156313786439,8.45903752854495,6.76115411285342,7.37509226120452,6.36818049984613,6.85148995727817,7.10366806071223,7.20680069982788,5.42474340880476,6.04401173297983,6.25583328074165,6.4473121942656,5.91483830760292,7.01170160307269,155061,"zinc finger protein 746","protein_coding","hsa05168","Herpes simplex virus 1 infection","GO:0000122,GO:0000976,GO:0000978,GO:0001227,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0045892,GO:0045944,GO:0046872,GO:0051260,GO:0051291","negative regulation of transcription by RNA polymerase II|transcription cis-regulatory region binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|negative regulation of DNA-templated transcription|positive regulation of transcription by RNA polymerase II|metal ion binding|protein homooligomerization|protein heterooligomerization","WP5294","Sildenafil treatment","R-HSA-212436,R-HSA-73857,R-HSA-74160","Generic Transcription Pathway|RNA Polymerase II Transcription|Gene expression (Transcription)"]
["ZNF747",3.71459304808252,4.57455681228448,4.11145269198837,3.9375120757589,3.52276203545036,4.13442566782609,3.96182147449374,3.93391983118056,5.08933886924304,4.64715205759286,5.24371723743038,4.61837912138748,4.29854955855222,4.06330165794749,4.08000626077702,4.53040223455374,4.06758675304287,4.26909358182502,4.36546546153744,3.72995284275637,3.88984250071757,4.09579481670606,3.50499574427855,3.90409992911857,3.60520256368279,3.9530753097449,3.88210694650599,4.43318904503922,65988,"zinc finger protein 747","protein_coding",null,null,"GO:0005515,GO:0006355,GO:0046872","protein binding|regulation of DNA-templated transcription|metal ion binding",null,null,"R-HSA-212436,R-HSA-73857,R-HSA-74160","Generic Transcription Pathway|RNA Polymerase II Transcription|Gene expression (Transcription)"]
["ZNF747-DT",0.264748542488994,0.183141664714803,0.542302707753211,0.138495960460622,0.211664561949521,0.361617997386362,0.516471271243321,0.37761686600054,0.411556315410097,0.301348012926594,0.362153743086005,0.387431317386776,0.183108011966504,0.160621568978727,0.470046175832166,0.068460500215572,0.532219344745167,0.356309093863217,0.200197840310543,0.115721733231757,0.499766732514598,0.251653247447892,0.356406948076468,0.681900931671931,0.524955705096622,0.388772590084152,0.465804185623996,0.248894262350083,107984875,null,"non_coding"]
["ZNF749",1.00952562290629,0.882692554754765,0.90657101489953,0.871975807505816,0.943576119641606,0.942107832223135,1.02378074945326,0.799328560270974,0.882996459591195,0.670345249647221,0.566102152486148,0.693933738980734,0.882530357745048,0.609756688935293,0.758080209142362,0.588578759704011,1.40465386495038,0.974690612661417,1.21119408802801,0.976810945688306,1.50916046867315,1.15031753617831,1.23185206772557,1.54986683349422,1.33656171400607,1.01881048195773,1.15286265062556,1.36171040950778,388567,"zinc finger protein 749","protein_coding","hsa05168","Herpes simplex virus 1 infection","GO:0000122,GO:0000977,GO:0001227,GO:0005634,GO:0046872","negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|nucleus|metal ion binding",null,null,"R-HSA-212436,R-HSA-73857,R-HSA-74160","Generic Transcription Pathway|RNA Polymerase II Transcription|Gene expression (Transcription)"]
["ZNF750",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,8.05657695342781E-3,0,0,0,0,0,0,0,79755,"zinc finger protein 750","protein_coding",null,null,"GO:0000122,GO:0000978,GO:0001227,GO:0001228,GO:0005515,GO:0005634,GO:0008544,GO:0010719,GO:0030154,GO:0045944,GO:0046872,GO:1990841","negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|protein binding|nucleus|epidermis development|negative regulation of epithelial to mesenchymal transition|cell differentiation|positive regulation of transcription by RNA polymerase II|metal ion binding|promoter-specific chromatin binding",null,null,"R-HSA-212436,R-HSA-73857,R-HSA-74160","Generic Transcription Pathway|RNA Polymerase II Transcription|Gene expression (Transcription)"]
["ZNF75A",2.67725766230274,2.90045440317421,2.76304104595666,3.11917996763471,3.0552688771583,2.58215217567207,2.78190957706505,2.4073244451379,2.53740835046674,2.63439518374971,2.49962694672126,2.96095321982758,2.90911294737748,2.31746573528289,2.26961461738012,2.35974761111162,2.38817117232994,2.78570089339815,2.7468282619398,2.97416057298401,2.88727323807449,2.58158056119172,3.35389715115918,2.93665672432298,2.75490949902396,2.79642722718029,3.17996116682714,2.56236395647349,7627,"zinc finger protein 75a","protein_coding",null,null,"GO:0000122,GO:0000977,GO:0001227,GO:0005515,GO:0005634,GO:0008150,GO:0046872,GO:1990837","negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleus|biological_process|metal ion binding|sequence-specific double-stranded DNA binding",null,null,"R-HSA-212436,R-HSA-73857,R-HSA-74160","Generic Transcription Pathway|RNA Polymerase II Transcription|Gene expression (Transcription)","zf-C2H2"]
["ZNF75D",1.52463198619681,1.6532600969123,1.56971749113156,1.23725530050051,1.64848378159704,1.45994593099201,1.45613575339191,1.30337637595456,1.72716024116771,1.25119471539494,1.44231243063034,1.81224845359521,1.75018903004128,1.62556768604976,1.82620944708257,1.8647161682992,1.57859832420777,1.85031105748915,1.48969665693917,1.76396894564785,1.59797224683788,1.74935298700543,1.80498940474603,1.69811578546808,1.48472320633388,1.48296277373622,1.71688646731557,1.60578246254339,7626,"embryonic testis differentiation homolog A","protein_coding",null,null,"GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0008270","RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|zinc ion binding",null,null,"R-HSA-212436,R-HSA-73857,R-HSA-74160","Generic Transcription Pathway|RNA Polymerase II Transcription|Gene expression (Transcription)"]
["ZNF76",5.57178975353776,6.69324217406779,7.30811078761945,6.85522689823205,6.13864027408914,7.17776486165464,6.62747987015979,6.38517676245767,6.21477880498495,8.97954593302245,7.3554091273493,6.67024217032627,6.00944109544749,7.61177811377641,7.06036967925778,7.07894977432644,6.97895951089535,6.99707729205999,7.33112315827768,7.40009194995068,7.25636402680842,7.34996034269991,7.53134286911629,6.52784580968436,6.80780028509501,7.08002903231839,6.96698832453481,7.08155821029299,7629,"zinc finger protein 76","protein_coding",null,null,"GO:0000978,GO:0000981,GO:0001228,GO:0005515,GO:0005634,GO:0006357,GO:0006359,GO:0007417,GO:0043565,GO:0045944,GO:0046872,GO:1990837","RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|regulation of transcription by RNA polymerase III|central nervous system development|sequence-specific DNA binding|positive regulation of transcription by RNA polymerase II|metal ion binding|sequence-specific double-stranded DNA binding","WP4906","3q29 copy number variation syndrome",null,null,"zf-C2H2"]
["ZNF761",0.173018069545847,0.126169482323848,0.167850074999924,0.105091785715377,0.129617247083622,0.151641265485081,0.139901056897597,0.141384149657883,0.145027270148792,0.138865481089244,0.0922043119966508,0.0928376284709434,0.1919617583731,0.10996769805989,0.134088197356201,0.180452152900266,0.177436152961496,0.138742522642502,0.186558154808474,0.10537263513786,0.157859955188024,0.24120807628724,0.176500488335686,0.214109628111175,0.120073892168208,0.0602793716156555,0.267882253093132,0.113859902953941,388561,"zinc finger protein 761","protein_coding","hsa05168","Herpes simplex virus 1 infection","GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872","RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding",null,null,"R-HSA-212436,R-HSA-73857,R-HSA-74160","Generic Transcription Pathway|RNA Polymerase II Transcription|Gene expression (Transcription)"]
["ZNF763",0.485025326032056,0.425851898575599,0.542928201072419,0.787206566493593,0.37368845385321,0.350356537260143,0.643976816016946,0.484760751855365,0.516016060029758,0.637827894275294,0.692979307704362,0.675658768037838,0.54995762763642,0.649155683623368,0.563838550017823,0.45103388377318,0.45735473103421,0.500558796223066,0.53447666402015,0.627860476496181,0.74831382408603,0.398972119263095,0.616949881975968,0.628771077432369,0.55484465842235,0.584939341726451,0.442272209464445,0.762889491141621,284390,"zinc finger protein 763","protein_coding","hsa05168","Herpes simplex virus 1 infection","GO:0000978,GO:0003700,GO:0005515,GO:0005634,GO:0006357,GO:0046872","RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding"]
["ZNF764",2.34648697028441,2.77187384433216,2.6115806073619,2.17782345687464,2.17269656819601,2.23901069634799,2.18042352735135,2.22673336216534,2.43638483584298,2.88874904850441,2.85629856340559,2.29412647396101,1.92555845507773,2.39043682860583,2.56938777756859,2.32350788610426,1.94671406517194,2.22364889044857,2.01126959416543,2.11995391394591,2.17901421011502,2.50922514319274,1.73737441027939,2.26472223346096,2.03556645978944,2.25655545856042,1.67552168981211,1.94801316791309,92595,"zinc finger protein 764","protein_coding","hsa05168","Herpes simplex virus 1 infection","GO:0000122,GO:0000977,GO:0001227,GO:0003712,GO:0005515,GO:0005634,GO:0046872,GO:0071385,GO:0140297","negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|transcription coregulator activity|protein binding|nucleus|metal ion binding|cellular response to glucocorticoid stimulus|DNA-binding transcription factor binding",null,null,"R-HSA-212436,R-HSA-73857,R-HSA-74160","Generic Transcription Pathway|RNA Polymerase II Transcription|Gene expression (Transcription)"]
["ZNF765",1.3796488112526,1.23937075815311,1.41704061285178,1.28923623735872,1.43455363654326,1.11838986943201,1.25419475659681,1.04645793793238,1.81473650889491,0.897209508841277,1.33629344835102,1.70835856485507,1.58116892223044,1.51206306405171,1.95749763513658,1.53731656943687,1.33211734505808,1.23835334678182,1.4494736216904,1.38906577422547,1.2354052371394,1.12646502556012,2.06630799876354,1.40548078715498,1.37366123420654,1.22127934222308,1.38640930839268,0.99771501013634,91661,"ZNF765-ZNF761 readthrough","protein_coding","hsa05168","Herpes simplex virus 1 infection","GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872","RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding"]
["ZNF765-ZNF761",0.0503102188041118,0.0622093747258199,0.0377864273163865,0.0627255563116416,0.108154261673845,0.0519682452384283,0.0187755919240638,0.0690676611945744,0.121452624533116,0.0920648593774648,0.0898963192057459,0.141725528570004,0.162671544785472,0.134300975928461,0.0514670442618273,0.085863113372274,0.0967404557369861,0.0139650820663075,0.06974666577946,0.0677311226977963,0.0759766181976111,0.0621682324279975,0.109267975620308,0.078642730146098,0.054866591051532,0.0956075139745407,0.0730264120799098,0.0709461401384743,110116772,"zinc finger protein 765","protein_coding","hsa05168","Herpes simplex virus 1 infection","GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872","RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding"]
["ZNF766",0.695932605552226,0.783405605104063,1.06396828419921,1.00115980891951,0.754902401057926,0.710474014287038,1.057344435186,0.945383769214996,1.08534259454431,0.910094498099922,0.981726572624189,0.950684142142824,0.989702707976225,1.09262232616509,1.08363716519021,1.11084809760811,1.06503061675777,1.05154223342863,1.05625725105157,1.41826275801612,1.1570328383784,1.20164127630258,1.42765379106329,1.16020844905908,1.40841223149388,1.21028990342468,1.41484435728141,1.15245299891826,90321,"zinc finger protein 766","protein_coding","hsa05168","Herpes simplex virus 1 infection","GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872","RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding"]
["ZNF768",8.41882335156205,10.2669878542893,11.8456096713757,12.0659302946165,8.98600005028489,10.3408520298142,11.1212596961269,10.6701440498023,9.38150341694728,13.2644846383906,12.3645592155744,9.82202596058958,8.48977756371778,10.1038801030434,9.84255497260347,9.55950374697922,8.4224258471781,10.719997394187,12.1042998535734,10.7570382903872,10.4417101694483,10.3568618042786,9.66655805134158,9.96362702715578,9.73651952286212,12.6444299338733,9.80561115088833,12.7221972036253,79724,"zinc finger protein 768","protein_coding","hsa05168","Herpes simplex virus 1 infection","GO:0000977,GO:0000981,GO:0003723,GO:0005515,GO:0005634,GO:0005694,GO:0006357,GO:0006366,GO:0046872,GO:1990837","RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|RNA binding|protein binding|nucleus|chromosome|regulation of transcription by RNA polymerase II|transcription by RNA polymerase II|metal ion binding|sequence-specific double-stranded DNA binding",{"$nulls":4},"zf-C2H2"]
["ZNF77",1.14320334491633,1.27272424346384,1.04888748616042,1.18361206369559,1.43444535262818,1.25651361983405,1.28476625085399,1.08280498925456,0.927766355816044,1.45138586985813,1.19728900123855,1.1370875772942,0.963633489481554,1.52338914578378,0.857787077502555,1.02234346988587,1.01169070623953,1.46644802968283,1.35673567173774,1.23674465356504,0.870568468117434,1.4324113870068,1.35944202010083,1.26917996422528,1.31371171413446,1.27140484740206,1.31996559588872,1.84416199994068,58492,"zinc finger protein 77","protein_coding","hsa05168","Herpes simplex virus 1 infection","GO:0000122,GO:0000977,GO:0001227,GO:0003674,GO:0005515,GO:0005634,GO:0008150,GO:0046872","negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|molecular_function|protein binding|nucleus|biological_process|metal ion binding",null,null,"R-HSA-212436,R-HSA-73857,R-HSA-74160","Generic Transcription Pathway|RNA Polymerase II Transcription|Gene expression (Transcription)"]
["ZNF770",7.11695625626201,6.86840168570062,6.46296405893789,5.12393463325784,8.12636945405511,6.8041893459313,6.1591605017837,5.23900877153902,8.5495535580688,4.81631751379758,5.35073998793737,5.85883909819128,9.80346627774333,5.80706477734453,8.46238675077876,8.16239477473693,5.34631619767514,5.44322901435828,5.98217370388832,7.83988679191729,6.93253115794206,6.7413744630478,10.353079051117,7.20001196748706,5.99949377253282,5.69811291091618,6.97807042556411,5.0879613335447,54989,"zinc finger protein 770","protein_coding",null,null,"GO:0000978,GO:0001228,GO:0005634,GO:0006357,GO:0045944,GO:0046872","RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase II|metal ion binding",null,null,"R-HSA-212436,R-HSA-73857,R-HSA-74160","Generic Transcription Pathway|RNA Polymerase II Transcription|Gene expression (Transcription)","zf-C2H2"]
["ZNF771",3.72881363484631,3.85459546003972,3.57367586473298,4.15975699366197,3.30204849765631,3.65960192359781,3.67222441700968,4.13891300774847,3.95905221989122,4.50162671198111,4.91916803769079,4.611214238638,4.02626550808192,3.91293274668638,3.68451181055761,4.03879684909285,3.63482050088668,4.09704116574708,5.77964690438634,4.12107213676054,5.14474739575765,5.39040333019117,4.0646141090911,4.28805435319485,4.49267829005929,5.04391629560498,5.21199534500318,5.87904288537687,51333,"zinc finger protein 771","protein_coding",null,null,"GO:0000981,GO:0005634,GO:0005654,GO:0005730,GO:0006357,GO:0046872,GO:1990837","DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|nucleoplasm|nucleolus|regulation of transcription by RNA polymerase II|metal ion binding|sequence-specific double-stranded DNA binding",null,null,"R-HSA-212436,R-HSA-73857,R-HSA-74160","Generic Transcription Pathway|RNA Polymerase II Transcription|Gene expression (Transcription)"]
["ZNF772",1.81803896486113,1.72565407275182,1.53615604725372,1.45663682642673,1.68398452483843,1.62186967494347,1.55839655382703,1.43363885335599,1.69154819468822,0.995883836452649,1.06147633564339,1.34895996133824,1.62448220817269,1.01468958005951,1.51816703130467,1.29283282688954,1.66417915104902,1.39479715540666,1.38272250407294,1.56979612380593,1.48716463789136,1.60210480064416,1.72002116668068,1.70586739395644,1.76865018171963,1.35677903311154,1.78860429741921,1.44923116928304,400720,"zinc finger protein 772","protein_coding","hsa05168","Herpes simplex virus 1 infection","GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872","RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding",null,null,"R-HSA-212436,R-HSA-73857,R-HSA-74160","Generic Transcription Pathway|RNA Polymerase II Transcription|Gene expression (Transcription)"]
["ZNF773",1.1252077437301,0.917838428229528,0.958269021798774,0.972228039832126,1.21524307816973,1.05335612058524,1.18306610999627,0.949654201650364,0.735849401612021,0.962933229368795,0.79937786662044,0.900735254560365,0.954111533017503,0.913330193210648,0.761339545588414,0.720053232214787,0.957895538161597,0.915407700439487,0.727636732710213,0.99827567028771,0.900916462288117,0.894052280695538,0.729088186019443,0.765764274744996,0.887610435836202,0.771244242381831,0.707916415474049,0.953025423355098,374928,"zinc finger protein 773","protein_coding","hsa05168","Herpes simplex virus 1 infection","GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872","RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding",null,null,"R-HSA-212436,R-HSA-73857,R-HSA-74160","Generic Transcription Pathway|RNA Polymerase II Transcription|Gene expression (Transcription)"]
["ZNF774",0.429344275984024,0.314136646166044,0.353473463029537,0.221720234013574,0.380810646998947,0.322540923912364,0.221856553237492,0.220222529056918,0.172744856432853,0.197214163361381,0.260899780610844,0.192718837122067,0.226136824384018,0.144838856613995,0.37471621956399,0.313141224542353,0.292127256120846,0.134456261835176,0.201456946224445,0.285830696147052,0.193267035184189,0.21975022387466,0.293439682807384,0.232314979974586,0.25539713081264,0.21966769291406,0.319591207975297,0.329116379967052,342132,"zinc finger protein 774","protein_coding",null,null,"GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872","RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding",null,null,"R-HSA-212436,R-HSA-73857,R-HSA-74160","Generic Transcription Pathway|RNA Polymerase II Transcription|Gene expression (Transcription)","zf-C2H2"]
["ZNF775",2.38445070634614,2.44944889030325,2.99973427611683,2.90427029572738,1.58438970348179,2.59738004314662,2.65848181617237,2.52523972309958,2.75819930924997,3.57110672141637,4.00275189726637,3.39452206874482,3.3673733470001,3.87594551237476,3.72544337501654,3.75296364442847,2.93440629435483,2.79090404790693,3.01915146859793,2.8776376511377,2.85822122282483,3.12778142620291,2.36574766772739,2.08494103587958,2.67131977150209,3.21723301646765,3.06882757587574,2.89174082460215,285971,"zinc finger protein 775","protein_coding",null,null,"GO:0003677,GO:0003700,GO:0005515,GO:0005634,GO:0006355,GO:0046872","DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|regulation of DNA-templated transcription|metal ion binding",null,null,"R-HSA-212436,R-HSA-73857,R-HSA-74160","Generic Transcription Pathway|RNA Polymerase II Transcription|Gene expression (Transcription)"]
["ZNF775-AS1",0,0.097489859544002,0.0274931664260183,0,0,0,0.0546440095215284,0,0.0147280273911016,0,0,0,0,0,0,0.0138829911717256,0,0.013547874291377,0,0.056320843550057,0,0,0.0144550346494892,0,0.0145165767050569,0.0278253699009011,0,0.0550612955077958,105375564,null,"non_coding"]
["ZNF776",3.12491282658652,2.85536719369108,2.84239997716335,1.98979373067712,3.21872441685812,2.89115719309089,2.47579836336428,2.30574494576156,2.61249511640027,2.49162991713127,2.19205562852323,2.62852490131279,2.96689264543218,2.66664771303337,3.54931611296048,3.03089284116679,2.85665630811941,2.43159626769823,2.57089232153511,3.01976104779915,3.32659767636267,2.85834820846105,3.62105485622047,3.28317705682906,2.98129711100794,2.57008695946703,2.90990406496237,2.28761527884738,284309,"zinc finger protein 776","protein_coding","hsa05168","Herpes simplex virus 1 infection","GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872","RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding",null,null,"R-HSA-212436,R-HSA-73857,R-HSA-74160","Generic Transcription Pathway|RNA Polymerase II Transcription|Gene expression (Transcription)"]
["ZNF777",4.75469038935725,6.83926262918794,7.78072880350306,7.47067894493902,6.0604392666994,6.72292119852244,7.231323833936,6.10466065127894,5.32266828244006,9.27117585337141,8.02822919502723,6.5373442555592,5.39492023709624,6.60291900189686,6.67979399989359,6.15353964986158,4.9828428259905,6.30021131614378,7.20650578361893,5.88924737527717,6.08890688385936,5.96930167891306,5.86932827809994,5.06334656917184,4.72934060585682,6.27021897769197,4.75163299746233,6.37206935775124,27153,"zinc finger protein 777","protein_coding","hsa05168","Herpes simplex virus 1 infection","GO:0003677,GO:0003700,GO:0005515,GO:0005634,GO:0008285,GO:0045892,GO:0046872,GO:0051291","DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|negative regulation of cell population proliferation|negative regulation of DNA-templated transcription|metal ion binding|protein heterooligomerization",null,null,"R-HSA-212436,R-HSA-73857,R-HSA-74160","Generic Transcription Pathway|RNA Polymerase II Transcription|Gene expression (Transcription)"]
["ZNF778",0.661314517295557,0.700651977283281,0.57004754682632,0.69518023573273,0.728997012926663,0.621008032878448,0.595043160345627,0.521555685361319,0.854571480020392,0.92932940817378,0.783496573570037,0.812137762393618,0.798999339801455,0.666381784343383,0.836075381725801,0.602481091472818,0.59056019486607,0.572695164835151,0.743881620710381,0.608776738048961,0.593084764715643,0.64650001693679,0.520431727684212,0.673677046228274,0.737306233423006,0.59482497785449,0.564788591753628,0.599587174853543,197320,"zinc finger protein 778","protein_coding","hsa05168","Herpes simplex virus 1 infection","GO:0000122,GO:0000977,GO:0001227,GO:0005515,GO:0005634,GO:0046872","negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleus|metal ion binding",null,null,"R-HSA-212436,R-HSA-73857,R-HSA-74160","Generic Transcription Pathway|RNA Polymerase II Transcription|Gene expression (Transcription)","zf-C2H2"]
["ZNF780A",1.54381642912143,1.28819626805619,1.2685808904575,1.13801397640532,1.53283496246765,1.178446297083,1.19112826827823,1.10874369044639,1.41226813655361,0.945388770320885,1.10131796266878,1.21256448262558,1.4090750217934,1.05131425650976,1.32885451875422,1.58158113427263,1.04228532658291,1.07779600298564,1.08232229767129,1.50846306328375,1.22258508848717,1.12494996491613,1.78474537169981,1.53557905443458,1.25648850280203,1.17175172142549,1.45484635251818,1.12429765892178,284323,"zinc finger protein 780A","protein_coding","hsa05168","Herpes simplex virus 1 infection","GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872","RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding"]
["ZNF780B",0.600721086124761,0.524978482338589,0.578292631043017,0.486929236551598,0.755351966172801,0.493952185343928,0.557622336530266,0.472448250901128,0.578172539987888,0.411167494142795,0.503287187082757,0.489329260025267,0.633628290277755,0.517477633994813,0.528890568885061,0.625954075877523,0.554102847214524,0.572754776447547,0.55519923939314,0.705221856635889,0.703702807650132,0.698542210521752,0.885050376037855,0.726907031546674,0.713473323586688,0.599767349514971,0.730321947143505,0.537513318526507,163131,"zinc finger protein 780B","protein_coding","hsa05168","Herpes simplex virus 1 infection","GO:0000978,GO:0001228,GO:0005634,GO:0006357,GO:0045944,GO:0046872","RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase II|metal ion binding"]
["ZNF782",0.257817148902431,0.122613441838816,0.191621307468589,0.20948556541511,0.311411080634199,0.228653250207104,0.160360714446015,0.196633649670844,0.262930896011202,0.182784456463282,0.141436238665363,0.118885008390469,0.187291670050754,0.150209331244718,0.133204725705183,0.196917910644861,0.210005692562201,0.24517549232352,0.261446229051199,0.161838258164711,0.246720896836015,0.211027938155512,0.28987260105688,0.216896921357043,0.170403938665312,0.16331510941836,0.20790409985343,0.208714346169329,158431,"zinc finger protein 782","protein_coding","hsa05168","Herpes simplex virus 1 infection","GO:0000978,GO:0001228,GO:0005634,GO:0006357,GO:0045944,GO:0046872","RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase II|metal ion binding",null,null,"R-HSA-212436,R-HSA-73857,R-HSA-74160","Generic Transcription Pathway|RNA Polymerase II Transcription|Gene expression (Transcription)"]
["ZNF783",2.20777456352057,3.46606285752631,3.44341921875883,3.13054130499571,2.95185022447729,2.62495494800272,3.02330434582271,3.36379973544294,3.14602273690854,3.69828310278643,4.20838277412579,3.32583598963241,2.72605983469286,4.09086373832214,3.64832552150373,3.65203055898246,2.8416007287066,2.72919272908439,3.07716392739176,2.92203745946364,2.40870720126326,2.8432253536565,2.43735689487433,2.70196734127616,2.87138015069062,2.57147586199106,2.78539006639096,2.778576993883,100289678,"zinc finger protein 783","protein_coding","hsa05168","Herpes simplex virus 1 infection","GO:0003677,GO:0003700,GO:0005515,GO:0005634,GO:0006355,GO:0046872","DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|regulation of DNA-templated transcription|metal ion binding"]
["ZNF784",2.60472739062238,2.59366202570436,3.6171708874799,3.26572591886345,2.38615308891256,2.48419006760133,2.98710501772465,2.7537334616748,3.01573223571767,3.71076520272894,4.10817582745775,3.49409622927581,2.4641712330067,3.07824325450927,3.26769225406558,3.00991912372037,2.908625709362,3.61509377568317,3.79909070557433,2.73958245154599,2.82980879425386,3.46882419321504,3.18751337289929,2.9291102269482,2.64963688457974,3.54486390200772,3.49200762408407,3.94094918397387,147808,"zinc finger protein 784","protein_coding",null,null,"GO:0000978,GO:0001228,GO:0002244,GO:0005515,GO:0005634,GO:0006357,GO:0045944,GO:0046872,GO:1990837","RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|hematopoietic progenitor cell differentiation|protein binding|nucleus|regulation of transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase II|metal ion binding|sequence-specific double-stranded DNA binding",{"$nulls":4},"zf-C2H2"]
["ZNF785",1.38626853399558,1.94808287019131,1.68352543758379,1.65545713410573,1.63863297240284,1.70070839845776,1.30589256547025,1.5128479286518,1.86669440066565,2.0113453203145,1.84621508378117,1.90309245318886,1.83715536890082,1.9952460327019,2.05443760991895,2.0267094334997,1.74125598494278,1.75021769563534,1.7275790923797,1.88349215176413,1.92044042113651,1.96379707364779,1.695238887732,2.09268363626843,1.80885985854612,1.96305953601959,1.60543260791707,1.92545093827439,146540,"zinc finger protein 785","protein_coding","hsa05168","Herpes simplex virus 1 infection","GO:0000122,GO:0000977,GO:0001227,GO:0005515,GO:0005634,GO:0046872","negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleus|metal ion binding",null,null,"R-HSA-212436,R-HSA-73857,R-HSA-74160","Generic Transcription Pathway|RNA Polymerase II Transcription|Gene expression (Transcription)"]
["ZNF786",1.00802300661551,1.35829592403001,1.45898412078614,1.57097318814791,1.42824659231753,1.37254821070922,1.16775814956691,0.91432940131636,1.06463122524284,1.48864488107756,1.22448367481556,1.00570360667866,1.23023020816386,1.14522327772928,1.36712297946407,1.33009784567576,1.17105994806204,0.715060942498946,1.21112726910626,1.38938203114776,1.00692399264676,1.06994870611008,0.953676429048492,1.0176379083676,1.24922176911856,1.07752856159558,1.02421761725238,0.947658258303386,136051,"zinc finger protein 786","protein_coding","hsa05168","Herpes simplex virus 1 infection","GO:0000978,GO:0001228,GO:0005515,GO:0005634,GO:0006357,GO:0045944,GO:0046872","RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase II|metal ion binding",null,null,"R-HSA-212436,R-HSA-73857,R-HSA-74160","Generic Transcription Pathway|RNA Polymerase II Transcription|Gene expression (Transcription)"]
["ZNF787",4.31603747228445,5.2147995367711,5.3281368577371,5.0926905949998,4.32647939984872,4.41017471130461,4.85490177276064,4.88379743534847,4.30563835793101,5.6809301355766,5.76175362471356,4.47495928022092,3.68007485197779,4.54031693760375,4.4148081086626,3.89990853281959,4.41292100154363,5.62653287825772,5.65768680768066,4.73076541798614,5.36617743955126,5.73200370412058,5.20718486195636,4.53872127564062,4.40975362844527,5.62383184266051,5.39859601776823,5.86464954782305,126208,"zinc finger protein 787","protein_coding",null,null,"GO:0000981,GO:0005634,GO:0006357,GO:0043565,GO:0046872,GO:1990837","DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|sequence-specific DNA binding|metal ion binding|sequence-specific double-stranded DNA binding"]
["ZNF789",0.827888263375371,0.581317970971253,0.651100426310336,1.09745633244885,0.775093684536167,0.687882442367047,0.501461371185584,0.731067224094952,0.863262757444863,0.747266436992389,0.599222064054509,0.811120075956879,0.737849618890592,0.590934474711895,0.632875592909042,0.604134467250457,0.891813534599591,0.749973635418799,0.729097707185883,0.92949542022717,0.846861664884624,0.663335432177111,0.795912477068017,0.855405663298,0.96259912653774,0.860776632207735,0.666911154332861,0.88425881859937,285989,"zinc finger protein 789","protein_coding",null,null,"GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0046872","RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|metal ion binding"]
["ZNF79",2.27956166684787,1.93322218519174,2.01292331697082,1.62820797986822,2.05614618822637,2.06577756046851,1.74755404046026,1.95396071999096,1.84396470674576,1.61976441829624,1.62658644514382,1.54766324597733,1.40985589343813,1.61856388846689,1.46767818355637,1.93465352077753,2.32193398339958,1.70358310105506,1.99632198209659,2.28405001084751,1.89578735800387,1.61374116206573,1.75470528980048,1.84550850652539,1.77007805083921,1.8024701988526,1.99764160505335,2.12806534509742,7633,"zinc finger protein 79","protein_coding","hsa05168","Herpes simplex virus 1 infection","GO:0000122,GO:0000977,GO:0001227,GO:0003674,GO:0005515,GO:0005634,GO:0008150,GO:0046872","negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|molecular_function|protein binding|nucleus|biological_process|metal ion binding",null,null,"R-HSA-212436,R-HSA-73857,R-HSA-74160","Generic Transcription Pathway|RNA Polymerase II Transcription|Gene expression (Transcription)"]
["ZNF790",0.688616738475788,0.589489891534412,0.746411375124021,0.822527487733312,0.7340588616921,0.85239727670032,0.654154529218706,0.779613083777242,0.837482975102977,0.536610274188484,0.647604231714407,0.919542049162298,0.875142333086543,0.680384909004176,0.774313564151454,0.902207428138952,1.02318870776348,0.752998781736014,1.07615250279951,0.957163318806848,0.951293514409412,0.577199020452203,1.26693041149337,1.14369149005693,1.16681452165207,0.975516370408693,1.01771615846506,0.829822697933648,388536,"zinc finger protein 790","protein_coding","hsa05168","Herpes simplex virus 1 infection","GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872","RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding",null,null,"R-HSA-212436,R-HSA-73857,R-HSA-74160","Generic Transcription Pathway|RNA Polymerase II Transcription|Gene expression (Transcription)"]
["ZNF790-AS1",0.71610438955105,1.99474982061285,1.17653275622613,1.54526802183768,1.6993857303474,0.912622270443761,1.28851507651167,1.07839351675676,1.59495873100107,1.05918262316047,1.05828608036517,1.18361370207345,1.19176561868142,1.2922873860907,1.35573090562598,0.897217940839123,1.42615991397764,1.34883613331521,0.921847107818313,1.18049343046286,1.27937524763095,1.50722800610502,1.41390536264112,1.47418744895901,1.03958797559241,0.850534966586604,1.95514014914664,1.10600589928206,284408,"ZNF790 antisense RNA 1","non_coding"]
["ZNF791",3.07137482680345,2.87865398447178,3.0483985541885,2.53433618151982,3.14489353188837,2.43160707939496,2.694088349284,2.34294100950335,3.08527850283192,2.39561133632834,2.69255820806519,3.21744098575291,3.0878669290715,2.69065464640728,2.8449663490771,2.62169139815431,2.57204289397269,2.79270748871882,3.07644088611891,3.14987544418467,2.80254865208462,2.57005211828878,3.64499905846932,3.05651226384526,2.8871117621347,2.85238499248907,3.00768351129579,2.79145542942055,163049,"zinc finger protein 791","protein_coding","hsa05168","Herpes simplex virus 1 infection","GO:0000977,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872","RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding",null,null,"R-HSA-212436,R-HSA-73857,R-HSA-74160","Generic Transcription Pathway|RNA Polymerase II Transcription|Gene expression (Transcription)"]
["ZNF792",0.85480623533588,0.869787847170602,0.684321673172686,0.997751953760889,1.19788313219547,1.12627827602881,0.945903521015086,0.740752849234098,0.926471848907456,0.79775965905989,0.897372106761782,0.946673376308888,0.554545404972303,0.878127751742107,0.881240290317925,0.797920481044163,0.955633041738148,0.692823238067366,0.58180515156347,0.739162614624876,0.850590738095821,0.74323976898886,1.04667527196498,0.873965185542298,0.74236160316694,0.724071802921494,0.724584288748438,0.7911575908795,126375,"zinc finger protein 792","protein_coding","hsa05168","Herpes simplex virus 1 infection","GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0042802,GO:0046872","RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|identical protein binding|metal ion binding",null,null,"R-HSA-212436,R-HSA-73857,R-HSA-74160","Generic Transcription Pathway|RNA Polymerase II Transcription|Gene expression (Transcription)"]
["ZNF793",0.277129931244096,0.233181558078951,0.130089749322636,0.194226574311456,0.29163044957326,0.296939518085809,0.0994460473795313,0.202072555155159,0.282328927867989,0.260067756185294,0.200480522072126,0.239495568544086,0.375049229729731,0.291307867292379,0.264337729038782,0.326767222152794,0.252779865401799,0.157796039986873,0.200306320021327,0.235744709217088,0.248155737630216,0.226272927237857,0.347246627149236,0.21868136394273,0.295887898771165,0.226187946564284,0.209725464358978,0.203751105404671,390927,"zinc finger protein 793","protein_coding","hsa05168","Herpes simplex virus 1 infection","GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872","RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding",null,null,"R-HSA-212436,R-HSA-73857,R-HSA-74160","Generic Transcription Pathway|RNA Polymerase II Transcription|Gene expression (Transcription)"]
["ZNF793-AS1",0.429825755459457,0.496443236926233,0.230591887882914,0.235558808983897,0.390007089595675,0.345967104560984,0.37237900907709,0.541910308839044,0.339700777559453,0.20698864739307,0.577466105148527,0.494217625823678,0.467154836907709,0.673220243555485,0.628155861400616,0.931520245909682,0.295179591024357,0.482924626078848,0.510755310131681,0.383806021834714,0.753427585981834,0.350198762238525,0.303094747035417,0.65988684928114,0.608770335171067,0.437584048868669,0.17825763823424,0.23090625291538,101927720,"ZNF793 antisense RNA 1 (head to head)","non_coding"]
["ZNF799",0.626141985809697,0.343595142258268,0.376823402250593,0.43113294818792,0.588307299442782,0.384447960294614,0.164770076953614,0.267637921703777,0.436025049153955,0.378842235520491,0.241579626120503,0.379585775521886,0.458042674365287,0.244902451807946,0.268757789636021,0.327283868411946,0.725484276546226,0.505071854314745,0.40805330431902,0.470882002048463,0.469757457168955,0.442563077432863,0.530966396340246,0.658779236940043,0.732192266137256,0.594947508491601,0.854482961120851,0.566005686214928,90576,"zinc finger protein 799","protein_coding","hsa05168","Herpes simplex virus 1 infection","GO:0000977,GO:0000981,GO:0005634,GO:0006357,GO:0046872","RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding",null,null,"R-HSA-212436,R-HSA-73857,R-HSA-74160","Generic Transcription Pathway|RNA Polymerase II Transcription|Gene expression (Transcription)"]
["ZNF8",0.55924529961152,0.714875696735282,0.613935081517906,0.689591302578904,0.719953811885381,0.647419268646715,0.496924584940836,0.528083301080887,0.678601541312859,0.604171849947569,0.640030215552654,0.637071474693074,0.647209438564372,0.592413251118027,0.82829944486195,0.676138244353721,0.557594571462125,0.662555000004709,0.396537739558875,0.515018875098616,0.505502005864481,0.579397637473084,0.581309773781802,0.612856494251044,0.542714410218641,0.444225463558414,0.60702824278025,0.475683356204849,7554,"zinc finger protein 8","protein_coding","hsa05168","Herpes simplex virus 1 infection","GO:0000122,GO:0000978,GO:0000981,GO:0003677,GO:0005515,GO:0005634,GO:0008270,GO:0030509","negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA binding|protein binding|nucleus|zinc ion binding|BMP signaling pathway",{"$nulls":4},"zf-C2H2"]
["ZNF8-DT",1.44408295903088,1.74556899181297,1.41224663477398,1.67349285556584,1.49929064714244,1.39373603159327,2.18938908461842,1.53406851812719,1.63412066412832,1.45844711384345,1.72588893189424,1.98760337305195,1.60219510470691,1.63489811281918,1.57614689911976,1.57839486608124,2.11152240034767,2.19909518868704,2.40978881855283,2.02513033155576,2.21487529182606,2.18290127521088,2.23744361848005,1.76353689225499,2.26685418109905,2.25831136887118,2.58133152866631,2.30981417711251,105372482,null,"non_coding"]
["ZNF8-ERVK3-1",0.046010181754202,0.0328224873822136,0.0323970040902281,0,0.0730587208587589,0.108014763460829,0.0160976565280244,0.0225587203926074,0.028925003655876,0.0498529151056124,0.0162262184868916,0.046290065657477,0.0382858655274533,0.038381940955019,0.0213946058269387,0.0708900421832536,0.0165885010189493,0.095786101614605,0.0691008357613613,0.0331832749015324,0.0434267890231278,0.0382675768565176,0.107877673779493,0.0224753439365688,0.0228077812792915,0.010929487089302,0.0612194107839517,0.0378480326012889,108903150,"ZNF8-ERVK3-1 readthrough","non_coding"]
["ZNF80",0,0,0,0,0,8.58658745490006E-3,0,0,0,0,0,0,0,0.00871758854701368,0,0,0.00879130532290997,0,0,0,0,0,0,0,0,0,0,0,7634,"zinc finger protein 80","protein_coding",null,null,"GO:0000977,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872","RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding"]
["ZNF800",0.915478090119035,0.921221816687506,0.640380015897893,0.661295365624682,1.00859021259432,0.733169069511054,0.580968653709039,0.581486284152577,0.926182009155554,0.535368153181268,0.575632194059413,0.678778570306532,1.03101390548059,0.664457885602447,0.833631668339286,0.863989060477714,0.620101334063935,0.515302790109528,0.593155442719137,0.784454089944106,0.833036931082823,0.582819345479831,0.956141011963517,0.711993927237119,0.729887147043518,0.522122901529958,0.788371430298565,0.451769251490723,168850,"zinc finger protein 800","protein_coding",null,null,"GO:0003677,GO:0003700,GO:0005634,GO:0006355,GO:0031018,GO:0046872,GO:0090425","DNA binding|DNA-binding transcription factor activity|nucleus|regulation of DNA-templated transcription|endocrine pancreas development|metal ion binding|acinar cell differentiation"]
["ZNF804A",8.46735985520559,7.24961040797279,5.18783357567905,5.94489397762493,7.11024190821963,5.32881303416042,4.83331514967674,4.95147717379988,7.07954511613331,6.64111601918873,6.01429609127587,6.84744415818776,8.1656384925553,4.53586511558217,5.41586227775696,5.46514512287126,6.76114493407985,6.33044851323582,6.48840890884976,7.44954503762576,6.78920816939726,5.91471295084069,8.59428603281545,7.14961567322334,6.38755669683204,5.04683491726337,6.96638095504463,5.84986735455022,91752,"zinc finger protein 804A","protein_coding",null,null,"GO:0003674,GO:0005634,GO:0005737,GO:0005886,GO:0010628,GO:0010975,GO:0010976,GO:0030426,GO:0043025,GO:0043197,GO:0043198,GO:0046872,GO:0098793,GO:0098794,GO:1901588,GO:1902952","molecular_function|nucleus|cytoplasm|plasma membrane|positive regulation of gene expression|regulation of neuron projection development|positive regulation of neuron projection development|growth cone|neuronal cell body|dendritic spine|dendritic shaft|metal ion binding|presynapse|postsynapse|dendritic microtubule|positive regulation of dendritic spine maintenance"]
["ZNF804B",0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.00427846625732837,0,0,0,0,0,0,0,0,0,219578,"zinc finger protein 804B","protein_coding",null,null,"GO:0005634,GO:0046872","nucleus|metal ion binding",null,null,"R-HSA-212436,R-HSA-73857,R-HSA-74160","Generic Transcription Pathway|RNA Polymerase II Transcription|Gene expression (Transcription)"]
["ZNF805",0.964899434126118,0.993420614187096,1.10746578467319,1.07284771941043,0.953220199223289,0.901111225663332,0.96207229754236,1.07094802000743,1.10920917943156,0.839963961384839,1.12930427704368,1.15478839905528,1.05878169963914,1.16758249374643,1.10936259415596,1.12096859958968,0.716158111302462,0.951652570491196,0.803582550632981,0.790217047459265,0.610483969379261,0.836541928061438,0.952568162007505,0.846858427796203,0.738492474937237,0.675027220211711,0.838804823202539,0.874720070938099,390980,"zinc finger protein 805","protein_coding","hsa05168","Herpes simplex virus 1 infection","GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872","RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding"]
["ZNF806",0,0,0,0,0,0,0.00663235901431526,0,0,0.00684659555496969,0,0.00715194942433395,0.00676031689749751,0.00677728139150747,0,0.00674013363585097,0,0,0,0,0,0,0,0,0,0,0,0,646915,"zinc finger protein 806","non_coding"]
["ZNF808",0.959665712456501,1.27327062135054,0.625513176138625,0.838303591359532,1.30209169678999,0.883955104722219,0.752786283551341,0.593397932286563,1.16204136115792,0.924281084824915,0.603589571810008,0.996251958994568,1.30210141842847,0.833338208216162,1.25629877380388,1.29241833211196,0.65820363408098,0.667372588505708,0.785255726367985,1.04039348734075,0.940398007502217,0.766943230317387,1.11636462042999,0.877849475255819,1.1877785650671,0.952510995687036,0.792606487284006,0.603380029939596,388558,"zinc finger protein 808","protein_coding","hsa05168","Herpes simplex virus 1 infection","GO:0000978,GO:0001228,GO:0005634,GO:0006357,GO:0045944,GO:0046872","RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase II|metal ion binding"]
["ZNF81",0.70893731685616,0.581852135587889,0.436297132575369,0.409311660786076,0.868825715335062,0.460888801313078,0.433580917840404,0.513829968953149,0.889579849879302,0.486407585835764,0.445962916985141,0.53195556903928,0.8004633824202,0.574163124575202,0.635052270277251,0.683420738071304,0.503791516256348,0.45412250594406,0.46456714851629,0.421805666736216,0.54828517500542,0.410182377596002,0.592203786946657,0.565208739455765,0.606478544305967,0.396510909218505,0.431347213145345,0.394540165588086,347344,"zinc finger protein 81","protein_coding","hsa05168","Herpes simplex virus 1 infection","GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872","RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding"]
["ZNF813",0.950674257443158,0.737567113868493,0.760910132228624,0.584025438119877,0.70207029522885,0.756970551980554,0.564064187023422,0.764684893607465,0.868115844323514,0.586503877438301,0.74985189125885,0.70081432837881,0.82908974701557,0.559682502666002,0.745595754286029,0.731076103932692,0.855046956389327,0.770178928714576,0.793604382775708,0.880485724521043,1.01721060046409,0.707929292644812,1.21532471638362,0.992984291854462,0.825248393574171,0.745127951549898,0.949625825526964,0.700167952830931,126017,"zinc finger protein 813","protein_coding","hsa05168","Herpes simplex virus 1 infection","GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872","RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding"]
["ZNF814",0.604399444736392,0.57899046468133,0.591750338803953,0.654181218319231,0.561064010748107,0.68107425516714,0.491397895041412,0.651939432332771,0.638341106465675,0.619535756137462,0.722683478355481,0.742721471671959,0.582989634512187,0.736739547653867,0.554058272601656,0.43389016579077,0.477326766587594,0.439394622477061,0.514708946687793,0.556294609975087,0.541940280672169,0.418567162489768,0.541269744761872,0.577828530317331,0.487932738532531,0.414307903967284,0.626642402184748,0.527619308691575,730051,"zinc finger protein 814","protein_coding","hsa05168","Herpes simplex virus 1 infection","GO:0000978,GO:0001228,GO:0005634,GO:0006357,GO:0045944,GO:0046872","RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase II|metal ion binding"]
["ZNF816",1.32750196307334,1.53594001793157,1.6462404873361,1.18764145929726,1.55855093351046,1.46055927647046,1.72842054630173,1.36974585351904,1.88335259195385,1.1258913122545,1.36023934374824,2.00336590798675,1.95019117485824,1.43561799248902,1.57545796530296,1.90679643868828,1.9335185309311,1.73244002639116,2.60030744603607,1.8100393114089,1.90749896503517,2.10934371453434,3.29590195962225,1.89700658379427,1.8661350112686,2.17444374919627,2.86638194931576,1.60191743340082,125893,"zinc finger protein 816","protein_coding","hsa05168","Herpes simplex virus 1 infection","GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872","RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding",{"$nulls":4},"zf-C2H2"]
["ZNF816-ZNF321P",0.447574894471961,0.309613078461253,0.401099361206149,0.458517443940072,0.387652329809437,0.410743461182245,0.26573484932224,0.339142694747655,0.419504239814244,0.29391272088051,0.373086686273507,0.460531565950319,0.40629249447662,0.581874363092747,0.539222782841428,0.453303236647511,0.508555449351247,0.329417841496182,0.59228342189987,0.489088080073844,0.403242317281075,0.328746334916492,0.52219221776034,0.745343894085129,0.605094740694563,0.444607410458058,0.679195235189102,0.277327123194878,100529240,"ZNF816-ZNF321P readthrough","protein_coding"]
["ZNF821",1.70158395687847,1.98182284522299,1.97243325160266,1.865049198087,1.90873034930325,1.72016032895219,1.94395403921031,1.94098717596413,2.31410276430268,3.00175917348012,3.25763415278329,2.60283970392533,2.16309239257048,2.62374427652207,2.29295740524032,2.33772580875675,1.89472024375847,2.32949262654534,2.15836841398319,2.19561956462136,2.42545260083794,2.37661459513372,1.91124421581489,2.12889099796338,2.20341530910999,2.3344768429113,2.35227363303841,2.66886355271833,55565,"zinc finger protein 821","protein_coding",null,null,"GO:0000978,GO:0003700,GO:0005515,GO:0005634,GO:0006357,GO:0046872,GO:1990837","RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding|sequence-specific double-stranded DNA binding"]
["ZNF823",0.884469403691795,0.879517017720609,0.594470529751842,1.09887920902387,1.09997525275283,1.17033714292081,0.853333851524159,0.443509741946943,1.01097309571283,0.871217796793459,0.97357512589489,1.15275984815304,1.01317035704061,0.747411327686247,0.719732648055218,0.800492649798784,1.52678946999489,1.66463569951756,1.05896347049673,0.918179896782926,1.74550756281961,1.39483218163783,2.17299269759374,1.46308245875969,1.76373159410132,1.22240730171654,1.91601483065023,1.92757647148488,55552,"zinc finger protein 823","protein_coding","hsa05168","Herpes simplex virus 1 infection","GO:0000977,GO:0000981,GO:0005634,GO:0006357,GO:0046872","RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding"]
["ZNF827",1.69781368338801,1.79071849943363,1.68716397967665,1.31971261878921,1.87310071611625,1.82576908902625,1.42595971469073,1.38963006688198,1.82999995097907,1.87587850234784,1.43412882262058,1.79079364480998,2.02965058597538,1.44732781393402,1.78428533539168,2.12095700816006,1.10249108708564,1.16869382787135,0.91112261545776,1.34628092847755,1.24386386759188,1.17133147903019,1.2334320454913,1.18384272091642,1.20305000376082,1.04729745574564,1.15105389869752,1.06194885269368,152485,"zinc finger protein 827","protein_coding",null,null,"GO:0000723,GO:0000781,GO:0000785,GO:0003677,GO:0005515,GO:0005634,GO:0006338,GO:0045892,GO:0045944,GO:0046872,GO:0070200,GO:0120325,GO:1904791,GO:1990904","telomere maintenance|chromosome, telomeric region|chromatin|DNA binding|protein binding|nucleus|chromatin remodeling|negative regulation of DNA-templated transcription|positive regulation of transcription by RNA polymerase II|metal ion binding|establishment of protein localization to telomere|NuRD complex binding|negative regulation of shelterin complex assembly|ribonucleoprotein complex"]
["ZNF829",1.28146709147515,0.671827929704314,0.838371769800024,0.890300316043577,1.07964904766316,0.781712122368049,0.729596731097499,0.786613460338015,1.09106759532264,0.505348717166814,0.754402238545243,0.659858691413001,0.983567273711148,0.543521985239638,0.83516845016533,0.798855322248462,1.06713250612511,0.826252980154456,0.755378712457523,0.834461339688034,1.00475451506516,0.891981088396798,1.28003214092371,1.09423123810663,0.965361860154202,0.853295720174573,1.21564169274583,0.825285655773642,374899,"zinc finger protein 829","protein_coding","hsa05168","Herpes simplex virus 1 infection","GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872","RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding"]
["ZNF83",7.95377662506443,9.13835709415381,8.26577269622482,8.74592077510022,9.91904095807072,7.47639663308001,7.1269086242521,8.06200425571706,10.1549899454973,7.00064095469553,7.3837889950255,7.97839134168678,8.99438537307858,8.76919626372905,7.14063720224149,8.34779432758114,6.4886562240115,6.40481990809341,6.60866672127146,8.51181861120627,7.30649857686336,7.59778534774824,9.01828623899013,8.36303575462818,7.32341998707018,7.53507033734616,7.83389288869477,5.95976593989417,55769,"zinc finger protein 83","protein_coding","hsa05168","Herpes simplex virus 1 infection","GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872","RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding",{"$nulls":4},"zf-C2H2"]
["ZNF830",6.21510592555203,5.39605065741473,6.20813019331424,6.30719762741134,5.21395536971871,5.7458159012775,5.6862610024287,5.29136055307281,6.49386235785601,5.55671897899427,6.66052192378014,5.81666321009637,5.63560315650259,6.22390637258052,7.13540456371974,5.35611134245393,6.94819519891115,6.76477810466849,8.37129525484816,6.64836352636573,6.96888146630966,6.93809781898748,8.10955863028686,7.14282347828797,6.65140074472899,6.42048030809217,7.69263748912551,7.51879458219636,91603,"zinc finger protein 830","protein_coding",null,null,"GO:0001541,GO:0001546,GO:0001832,GO:0003676,GO:0005515,GO:0005634,GO:0005654,GO:0005681,GO:0005694,GO:0006396,GO:0006397,GO:0008270,GO:0008380,GO:0016607,GO:0033260,GO:0033314,GO:0043066,GO:0044773,GO:0051276,GO:0051301,GO:0060729","ovarian follicle development|preantral ovarian follicle growth|blastocyst growth|nucleic acid binding|protein binding|nucleus|nucleoplasm|spliceosomal complex|chromosome|RNA processing|mRNA processing|zinc ion binding|RNA splicing|nuclear speck|nuclear DNA replication|mitotic DNA replication checkpoint signaling|negative regulation of apoptotic process|mitotic DNA damage checkpoint signaling|chromosome organization|cell division|intestinal epithelial structure maintenance","WP5287","17q12 copy number variation syndrome","R-HSA-5696398,R-HSA-6781823,R-HSA-6781827,R-HSA-6782135,R-HSA-6782210,R-HSA-72163,R-HSA-72172,R-HSA-72203,R-HSA-73894,R-HSA-8953854","Nucleotide Excision Repair|Formation of TC-NER Pre-Incision Complex|Transcription-Coupled Nucleotide Excision Repair (TC-NER)|Dual incision in TC-NER|Gap-filling DNA repair synthesis and ligation in TC-NER|mRNA Splicing - Major Pathway|mRNA Splicing|Processing of Capped Intron-Containing Pre-mRNA|DNA Repair|Metabolism of RNA"]
["ZNF835",0.023098727708006,0.0439414448330292,0.014457274890117,0.0221530242382029,0.0300948058501969,0.0361514707469942,0.0215509043549986,0.0226505403770675,0,0.088988141711894,0.0941330780372078,0.054224891607975,0.0366111420669959,0.0880872357723953,0.021481687555883,0.0219011026110941,0.00740267583317297,0.0356207320343119,0.035580561291664,0,0.0218017737951371,0.0805060374583376,0.00760117646092821,0,0.0687018450231616,0.0219479460100938,0.0447044291258677,0.0361924610932063,90485,"zinc finger protein 835","protein_coding",null,null,"GO:0000978,GO:0003700,GO:0005515,GO:0005634,GO:0006357,GO:0046872","RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding","WP2849","Hematopoietic stem cell differentiation"]
["ZNF836",1.28214016780158,1.20763018821223,1.52079630186631,1.77549036395612,1.30785672101214,1.90877249200458,1.57551611443539,1.77856667745034,1.90617921656299,1.81916744408872,2.40567556022095,2.13311952705062,1.73676462394215,2.03926038387841,2.05322567757159,2.00436248736326,1.47322695650231,1.48723911800447,1.7861425257714,1.51560566066502,1.44037389434285,1.30789622803545,1.91406794079118,1.6925589650524,1.308347734955,1.47380202841236,1.71277604031765,1.56990804077555,162962,"zinc finger protein 836","protein_coding","hsa05168","Herpes simplex virus 1 infection","GO:0000978,GO:0001228,GO:0005634,GO:0006357,GO:0045944,GO:0046872","RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase II|metal ion binding"]
["ZNF837",0.415603175014504,0.422887171302738,0.653329902492216,0.482012951907889,0.396665511099377,0.562718576069133,0.369718938929229,0.540226351861655,0.573590393400528,0.521293746607717,1.06347764642322,0.583439058094105,0.661788727365493,0.755595190032592,0.35954290968398,0.604828513915989,0.48320973136637,0.465028720567268,0.705689212010551,0.548360855643927,0.556472883167596,0.7992793908316,0.505708532038226,0.462688680038026,0.6707605736754,0.65204050288933,0.505052655907839,0.572443011552589,116412,"zinc finger protein 837","protein_coding",null,null,"GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0042802,GO:0046872","RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|identical protein binding|metal ion binding"]
["ZNF839",1.74389554243467,2.08199715211177,2.03618912776265,2.01853125002096,1.8842609031239,1.88607126239436,1.55223241130988,1.87909880077008,1.80654457098515,1.85720726586527,1.97935009791949,1.95213757184175,1.72324137377162,2.02950751047481,1.68519430082204,1.71809655111695,1.78457222286846,1.9807902927732,1.61915577634992,2.01236032470597,1.6951689721116,1.87484459295991,1.56725768006023,1.85257050176681,1.71304024906874,1.72177131962943,1.35002854988703,2.18218256515037,55778,"zinc finger protein 839","protein_coding",null,null,"GO:0046872","metal ion binding",null,null,"R-HSA-212436,R-HSA-73857,R-HSA-74160","Generic Transcription Pathway|RNA Polymerase II Transcription|Gene expression (Transcription)"]
["ZNF84",3.74682329685626,3.95504536341693,3.98885355164051,3.42294300347121,4.16529681889457,3.80648062674214,3.74614572024703,3.63994535303081,4.51203802373576,3.66238153165109,4.29068366679217,3.93442664436998,5.04482223814619,4.40618982085942,4.6579181427175,4.74225135533434,3.33426225129026,3.13141053916251,3.45645140607991,3.79742049655473,3.66803427348091,3.66088416016071,4.751846864312,3.93295633793821,3.63175505785161,3.54028542156067,4.21934031912008,3.69938896556449,7637,"zinc finger protein 84","protein_coding","hsa05168","Herpes simplex virus 1 infection","GO:0000978,GO:0000981,GO:0003677,GO:0005515,GO:0005634,GO:0006357,GO:0008270","RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA binding|protein binding|nucleus|regulation of transcription by RNA polymerase II|zinc ion binding",{"$nulls":4},"zf-C2H2"]
["ZNF84-DT",0,0,0,0,0,0.0219924064440012,0,0,0,0,0,0.0235622868958074,0,0.022327933133446,0,0,0,0,0,0,0,0,0,0,0,0,0.0906517268286491,0,101928597,"ZNF84 divergent transcript","non_coding"]
["ZNF841",1.70239361867516,2.02878062215738,1.66331385549176,1.84152758637072,2.21478599224091,1.45921857583114,1.6714275286188,1.43642765991026,2.21513912245696,1.806445390223,1.53119161066104,1.732665116861,2.01428898054579,1.94385419994082,1.50497618992343,1.91912281615257,1.96980759868966,1.64384937190795,1.64199554560233,1.99873336927552,1.59279428611225,1.60877981044513,1.96400054221833,1.78889832482827,1.73194992712419,1.45300076649125,1.97780782175725,1.74932576332037,284371,"zinc finger protein 841","protein_coding","hsa05168","Herpes simplex virus 1 infection","GO:0000978,GO:0001228,GO:0005634,GO:0006357,GO:0045944,GO:0046872","RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase II|metal ion binding"]
["ZNF843",0.0700889631701589,0.159998958253182,0.131604054576962,0.067219394919352,0.150673565795233,0.35541238432669,0.196177109066173,0.274916075091397,0.253799985276301,0.310521413376098,0.197743853479098,0.0564122563017667,0.133307965030216,0.36083472594285,0.130364687351614,0.186073954477408,0.161727101977775,0.0907911887638983,0.272066401115385,0.323515360298455,0.105845741108372,0.106595428408883,0.0968705312157918,0.0958649972978274,0.166770781366676,0.186471940672341,0.0949533233305286,0.131783469877602,283933,"zinc finger protein 843","protein_coding",null,null,"GO:0005515,GO:0046872","protein binding|metal ion binding"]
["ZNF844",2.25450499472012,2.53994111529756,2.57973802700106,2.00580356529176,2.35438944084202,2.13240860830222,2.54085553468925,2.08683004895035,2.67370274870173,1.97112367708884,2.00904405571607,2.28872765534293,2.48131849246805,2.6119224284018,2.53269486151148,2.49710330288216,1.82655988064782,1.88986084721461,2.15902006449038,1.87002960561809,1.75466689785689,1.64696345192208,2.3826584276328,2.39775582624321,2.08157654608516,1.88651757531315,2.33550217208208,2.03900837703725,284391,"zinc finger protein 844","protein_coding",null,null,"GO:0000977,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872","RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding"]
["ZNF845",1.2850110292058,1.24197253789371,1.09744789082458,0.814974435433872,1.21515356698684,1.25729400598272,1.29558946687143,1.17878246652483,1.40095406296757,0.982119548628862,0.896613142193554,1.08847765164637,1.44673068658142,0.932657303496346,1.47261378168342,1.22231592778143,1.22350419871215,1.06624249832049,1.65885735877459,1.30345771424877,1.60410498350903,1.17810855836257,2.31619757573053,1.51865394381485,1.29864763918608,1.24462370383427,1.89731220495285,1.17688333073256,91664,"zinc finger protein 845","protein_coding","hsa05168","Herpes simplex virus 1 infection","GO:0000978,GO:0001228,GO:0005634,GO:0006357,GO:0045944,GO:0046872","RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase II|metal ion binding"]
["ZNF846",1.03812064326045,1.19880034446458,1.28161673170585,1.11740626521678,1.47352814034657,0.942055129217564,1.20551307155686,1.14250115269743,1.1400076008062,1.06099573071751,0.92255157966674,1.21371723501216,1.30424832925852,1.20764114516569,1.03630484178284,1.19199156187376,0.799692997301602,0.887100959164811,0.668976569985216,1.03491291186983,1.04874979467951,0.817783467686474,0.97470787228827,1.03282490375758,1.04810162510485,0.733013835530374,0.832533779417002,0.978938086497218,162993,"zinc finger protein 846","protein_coding","hsa05168","Herpes simplex virus 1 infection","GO:0000122,GO:0000977,GO:0001227,GO:0005515,GO:0005634,GO:0046872","negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|protein binding|nucleus|metal ion binding"]
["ZNF85",1.06194892818639,0.728204145544891,0.336196212166443,0.746089095289471,1.09802270849978,0.869672233750986,0.437790382284366,0.647812717898316,0.863235795088303,0.499503524721343,0.499350786389773,0.509357709986279,0.757428011020399,0.429697646741075,0.459351889651223,0.503444448065651,0.991319347538649,0.588407825642188,0.610569277314996,0.92619794916412,1.04311450604387,0.83922842025683,1.18856737608643,1.0435269758538,0.881448133490018,1.00317596471284,0.842416365022234,0.951919754059537,7639,"zinc finger protein 85","protein_coding","hsa05168","Herpes simplex virus 1 infection","GO:0000122,GO:0000978,GO:0000981,GO:0001227,GO:0005634,GO:0005654,GO:0006355,GO:0046872","negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|nucleus|nucleoplasm|regulation of DNA-templated transcription|metal ion binding",{"$nulls":4},"zf-C2H2"]
["ZNF850",0.286619508466018,0.19948002899434,0.078757654652956,0.144146902139167,0.307396666731669,0.154269088615292,0.101095314685008,0.133674020251747,0.281268655881931,0.255852446340485,0.0821795967842983,0.246163570435062,0.149582530522429,0.113301521686239,0.0975199534921506,0.115994623463452,0.144504801342499,0.113194668045238,0.0936840977017986,0.134448486742291,0.145160461726231,0.112963924731419,0.103520690312667,0.102446126521037,0.152476760816446,0.159418587098212,0.0642655152365057,0.13801379315527,342892,"zinc finger protein 850","protein_coding","hsa05168","Herpes simplex virus 1 infection","GO:0000978,GO:0001228,GO:0005634,GO:0006357,GO:0045944,GO:0046872","RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase II|metal ion binding"]
["ZNF852",0.521391115357669,0.571579711971893,0.542045907578338,0.584797717429618,0.604469517241921,0.442587866979265,0.368275305565073,0.55460284985764,0.654820233020546,0.499329373906932,0.659324812568336,0.708307937917251,0.591084108129224,0.516741229454019,0.471193339849969,0.533459738684849,0.549432085000118,0.654135370659168,0.536330595151935,0.603356500486682,0.539381268022233,0.523601555175158,0.680487618488915,0.641767346679208,0.64541896129343,0.58498195560047,0.490288046763231,0.465244180008063,285346,"zinc finger protein 852","protein_coding",null,null,"GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872","RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding"]
["ZNF853",0.0136590905676428,0.0454722146999006,0.0192354646783505,0,0.10677670664458,0.0897860748514404,0.0191157122236763,0.0200910924398564,0.858699595484488,1.00639230369903,0.956996083199147,0.968823689538252,0.740411419048747,0.918070077567794,0.908255764128026,1.28213837748545,0.124757687800059,0.214850682390285,0.132552239509725,0.105078969319133,0.0902450925424247,0.149309893688134,0.168556617619139,0.20684064149681,0.169274244451544,0.201168189208807,0.138785336279153,0.0577850649397434,54753,"zinc finger protein 853","protein_coding","hsa05168","Herpes simplex virus 1 infection","GO:0000978,GO:0000981,GO:0006357,GO:0046872","RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|regulation of transcription by RNA polymerase II|metal ion binding"]
["ZNF860",0.172332990780065,0.359560455369134,0.0939439625722206,0.0853044480461382,0.380250261379034,0.198371596833929,0.197091442467884,0.136281607651257,0.206894007382898,0.128499684113566,0.0575084310530468,0.0727082901262047,0.0845869141688944,0.0847991785080514,0.108569131147045,0.100147071189068,0.106895310752479,0.102873320562694,0.118170902738241,0.251251476070106,0.204632734736662,0.174377172906768,0.131714013395139,0.195520196592346,0.181877827296829,0.100361271784246,0.172142936819591,0.224727641590206,344787,"zinc finger protein 860","protein_coding","hsa05168","Herpes simplex virus 1 infection","GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872","RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding",null,null,"R-HSA-212436,R-HSA-73857,R-HSA-74160","Generic Transcription Pathway|RNA Polymerase II Transcription|Gene expression (Transcription)"]
["ZNF862",1.87169718591883,2.4036541848212,2.04839768818171,1.85973031582007,2.34283998712577,2.23881157361361,1.84944276698132,2.06017485772981,2.32757059033332,3.2235319977445,2.42981791008979,2.39319755232211,2.45450839852648,2.94663040399594,1.8861416000042,2.73869398761324,1.74247805480567,1.60704491759418,1.66006973536146,1.89063493244753,2.03643181742271,1.96369415662828,1.74393955050123,1.66260035683768,2.013400534132,1.74769770302727,1.62069098141671,1.90920428482938,643641,"zinc finger protein 862","protein_coding",null,null,"GO:0003674,GO:0005575,GO:0005634,GO:0006355,GO:0008150,GO:0046872,GO:0046983","molecular_function|cellular_component|nucleus|regulation of DNA-templated transcription|biological_process|metal ion binding|protein dimerization activity"]
["ZNF865",5.64483061529938,8.12189237512794,7.76104397773132,8.25798572993656,6.25087631852343,8.22025072985103,6.50301831968158,7.15796201217606,5.46176938816895,10.5767183359113,9.02737738545503,7.1566172924674,5.82461574073625,7.90857408992255,6.70197824979585,7.08413658710449,5.26875567109567,7.31745064410029,6.03141289236286,6.75768178242875,6.68689892339007,7.0747191793338,4.45532363473746,4.7240105963142,5.78106947095509,7.34432633013235,4.81772492811212,7.5291822178697,100507290,"zinc finger protein 865","protein_coding",null,null,"GO:0000978,GO:0003700,GO:0005634,GO:0006357,GO:0046872","RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity|nucleus|regulation of transcription by RNA polymerase II|metal ion binding"]
["ZNF875",2.62654305100892,2.70244657126578,2.97152885663335,3.17402450188408,2.85638028615437,3.01252346454485,2.676296576803,3.05395658531782,2.96384759119715,3.10104090548243,3.10140348972595,2.73675604101647,2.38647505968216,3.18499060190046,2.55518562066189,2.64577812714782,2.7091221315158,3.17412748594234,2.95412825893304,3.11870657458988,2.85847863539681,2.71920778689369,2.75864929107168,2.85965154093759,2.70074741050802,3.26701547524536,2.91931831291321,2.85083305299678,284459,"zinc finger protein 875","protein_coding","hsa05168","Herpes simplex virus 1 infection","GO:0000122,GO:0000977,GO:0001227,GO:0005634,GO:0046872","negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|nucleus|metal ion binding",null,null,"R-HSA-212436,R-HSA-73857,R-HSA-74160","Generic Transcription Pathway|RNA Polymerase II Transcription|Gene expression (Transcription)"]
["ZNF878",0.0216864161184578,0.0206273797747968,0.0407199673292838,0.0415970704521042,0.0635731588585314,0.0305469748395559,0.0404664607920892,0.0212656320354286,0.0218135948729028,0.0208867983462953,0.0203948206082223,0.0654550093734698,0.0206235894411187,0.0103376713743348,0.020168245677969,0.0514050417279704,0.135526140464682,0.0501641926195197,0.0300645724252893,0.0834164706159735,0.0409375221543443,0.0206137378147912,0.0749324342429476,0.0211870348010254,0.0430008330072564,0.030908993958704,0.104927732883925,0.0305816105279119,729747,"zinc finger protein 878","protein_coding","hsa05168","Herpes simplex virus 1 infection","GO:0000977,GO:0000981,GO:0005634,GO:0006357,GO:0046872","RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding"]
["ZNF879",0.562360290327171,0.529019939341249,0.539567572592604,0.444507896939181,0.658210039298933,0.562903760259835,0.686116171593703,0.448430849583402,0.615386415468776,0.428538492618075,0.499808696326857,0.50982479637783,0.423138184461797,0.542033355196438,0.534486252207139,0.703124807349295,0.74268592652277,0.537485978363129,0.72535892826358,0.873563785386365,0.711601499841552,0.740138099284036,1.27506859858994,0.887509441971152,0.8638760884171,0.745732033519026,0.699667359974421,0.73202364017431,345462,"zinc finger protein 879","protein_coding","hsa05168","Herpes simplex virus 1 infection","GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872","RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding"]
["ZNF880",2.40311162491754,2.33728109188458,2.25150399553123,2.50308129732752,2.31453604541562,2.28901417782927,2.41666975357711,2.11504075841734,2.46178412828426,1.86867782164986,2.26924979683046,2.31368830204123,2.36495002667735,2.24881933623121,2.45012499398571,2.61935826911754,1.25464807167769,1.02062962948031,1.4336418231957,1.28329778847289,1.45014852866361,1.47914301220244,1.95431329073132,1.36632764508213,1.45976987513499,1.33353618984785,1.54870956857083,1.32867060301276,400713,"zinc finger protein 880","protein_coding","hsa05168","Herpes simplex virus 1 infection","GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872","RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding"]
["ZNF883",0.963126647749333,1.12086701901956,0.9467691941439,1.30403930824629,1.41722626692276,0.808662356492412,0.983161496659252,0.822217471997814,0.888993391049777,0.753004637985166,0.927077047244124,0.843587315705549,0.915924902228414,0.604947145039678,0.674411214869185,0.590887881922269,0.403077099370209,0.566140552670433,0.712113750784688,0.599281947631466,0.705849609604477,0.829323858760605,0.928445842600211,0.431729250125812,0.471816201760577,0.710582050268787,0.460517631184379,0.5965320850853,169834,"zinc finger protein 883","protein_coding",null,null,"GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872","RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding"]
["ZNF888",1.0339829605059,0.919695442544588,0.487993728312033,0.750437715122867,0.972134611243728,0.624565191422019,0.495384825070895,0.564507071089342,0.579053024669889,0.500620568532737,0.399472924158728,0.365501242817713,0.526202995201274,0.314382668703957,0.280682767239609,0.418645729426623,0.725433069129527,0.718823861349596,0.697350967700004,0.677198880102246,0.902072687795185,0.749082631273844,0.85523873365229,0.775376065641673,0.809009451844379,0.701005472771903,0.76259379010721,0.620018956744897,388559,"zinc finger protein 888","protein_coding","hsa05168","Herpes simplex virus 1 infection","GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872","RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding"]
["ZNF891",0.244619924470806,0.214117300913644,0.20711482992913,0.204379593509049,0.261029129831227,0.212799367129153,0.252031119519598,0.194253415089911,0.301907342467633,0.186456711637535,0.169362623422917,0.22195013116078,0.2797285295825,0.187430580436149,0.210747051332537,0.278893386173076,0.189015511638122,0.241612557802805,0.252436178654326,0.212141478223768,0.209637855628599,0.215402198623293,0.333350224233642,0.275641411894155,0.297572850618081,0.188227891948496,0.373224242261471,0.235614493374698,101060200,"zinc finger protein 891","protein_coding","hsa05168","Herpes simplex virus 1 infection","GO:0000122,GO:0000977,GO:0001227,GO:0005634,GO:0046872","negative regulation of transcription by RNA polymerase II|RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|nucleus|metal ion binding"]
["ZNF90",0.784782975598691,0.54785968077078,0.439365619707463,0.421209224477817,0.67539689283038,0.371856113765356,0.268695570323541,0.374187653008014,0.470734347691288,0.50620918673731,0.352093916889171,0.362182054181014,0.362890344228488,0.267702614964545,0.348182352468271,0.184316731349617,0.699143583676762,0.306441047606719,0.419217699795581,0.463876007570038,0.618398229626649,0.342185845403117,0.483332499385752,0.527553771187391,0.471114094317481,0.294169305217018,0.418029397354868,0.392583801531211,7643,"zinc finger protein 90","protein_coding","hsa05168","Herpes simplex virus 1 infection","GO:0000978,GO:0000981,GO:0003700,GO:0005634,GO:0006355,GO:0006357,GO:0008270","RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|nucleus|regulation of DNA-templated transcription|regulation of transcription by RNA polymerase II|zinc ion binding"]
["ZNF91",1.32068946034436,1.45808324488601,1.23253011638671,0.942424150116024,1.74374123424536,1.26603209641973,1.20652068690161,1.19485068419535,2.02823492170608,1.15842240382038,0.872379678591543,1.11517850761373,2.01477552974517,1.17292624299426,1.61936779153222,2.23982365631894,1.39069271767766,1.28017732178327,1.48580128138189,1.64420030418525,1.67688638794898,1.45338273612898,2.59986170736446,1.72036992526074,1.6639811262587,1.25115773591661,1.95124273033044,1.241600901503,7644,null,"protein_coding","hsa05168","Herpes simplex virus 1 infection","GO:0000122,GO:0000978,GO:0001227,GO:0001228,GO:0003700,GO:0005634,GO:0006357,GO:0008270,GO:0010526,GO:0045944","negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA-binding transcription factor activity|nucleus|regulation of transcription by RNA polymerase II|zinc ion binding|retrotransposon silencing|positive regulation of transcription by RNA polymerase II"]
["ZNF92",0.861089929936272,1.02184914233936,0.538948031232276,0.794374964370021,1.4664763079192,0.746999148844965,0.512638777186794,0.828298632145998,1.979747983719,0.853035399209025,0.964053925160494,0.915832472192045,1.98093121555487,0.664573574113382,1.12875909580222,1.22077825351447,1.23788639806338,0.865027857933822,1.27334028438061,1.54567903127687,1.67966516401178,1.34857242651502,2.84980986126492,1.62643848625127,1.32527468432723,1.2233893276615,1.80936654762616,1.1410435856722,168374,"zinc finger protein 92","protein_coding","hsa05168","Herpes simplex virus 1 infection","GO:0000978,GO:0000981,GO:0003700,GO:0005515,GO:0005634,GO:0006355,GO:0006357,GO:0008270","RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|regulation of DNA-templated transcription|regulation of transcription by RNA polymerase II|zinc ion binding",null,null,"R-HSA-212436,R-HSA-73857,R-HSA-74160","Generic Transcription Pathway|RNA Polymerase II Transcription|Gene expression (Transcription)","zf-C2H2"]
["ZNF93",1.2780543596876,1.15996349348862,0.72359367206545,1.16958827750555,1.10586157914029,0.906989765431593,0.446017142139663,0.832315133529964,1.53088329881101,1.24972298798812,0.844107891955799,1.13859656068788,1.26180837779306,1.0138400879439,1.13414447058068,0.823276952767309,1.64148911186726,1.28183582808555,1.05496943717752,1.67932631764768,2.03504526752892,1.41885633147997,1.37729851137476,1.93489080865289,1.93449277698225,1.77058679761559,1.21786805535568,1.79769251048235,81931,"zinc finger protein 93","protein_coding","hsa05168","Herpes simplex virus 1 infection","GO:0000122,GO:0000978,GO:0000981,GO:0001227,GO:0003700,GO:0005634,GO:0006357,GO:0008270,GO:0010526","negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|nucleus|regulation of transcription by RNA polymerase II|zinc ion binding|retrotransposon silencing"]
["ZNF98",0.0230592089266408,0,0,0,0.0112662441490097,0,0,0,0.0231944383464655,0.0333134606643863,0.0108429264397007,0.0347992201245607,0.0438582064590429,0.0219841326232646,0,0.0109318164016881,0,0.0426717477680499,0.0106559063372211,0,0,0.0109593139879321,0,0.033792323683928,0.0114307175851197,0.0109551980298457,0.0111569864820118,0,148198,"zinc finger protein 98","protein_coding","hsa05168","Herpes simplex virus 1 infection","GO:0000978,GO:0000981,GO:0005634,GO:0006355,GO:0006357,GO:0046872","RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of DNA-templated transcription|regulation of transcription by RNA polymerase II|metal ion binding"]
["ZNF99",0,0,0,0,0,0.00966032050008092,0.00319932647020524,0,0,3.30267018756456E-3,0.00322487749853967,0.00689993441472442,0.00652210194003576,0,0,0.00650262988096855,0,0.00634566507325409,0,0,0,0.0162974660372633,3.38528416101128E-3,0,0.00339969694873551,0,0,0,7652,"zinc finger protein 99","protein_coding","hsa05168","Herpes simplex virus 1 infection","GO:0000978,GO:0001228,GO:0005634,GO:0006357,GO:0045944,GO:0046872","RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|positive regulation of transcription by RNA polymerase II|metal ion binding",null,null,"R-HSA-212436,R-HSA-73857,R-HSA-74160","Generic Transcription Pathway|RNA Polymerase II Transcription|Gene expression (Transcription)"]
["ZNFX1",11.7225322184057,11.6195498137407,9.51004415510625,10.1631585097066,13.4278346046489,11.4259047641372,8.5612245537694,10.2887369704294,10.1814961633982,11.6396341230748,9.4278530954294,10.3266649515701,9.80030452727922,9.38641345253963,8.13729542847195,9.90576936766936,10.8930236258252,10.7357328725245,7.63406039912313,10.8735087764731,11.9043037833033,9.96622896310368,8.37591759382039,9.30820001228393,12.1261663119054,9.16307108766226,7.7397542753204,9.83235755820837,57169,"zinc finger NFX1-type containing 1","protein_coding",null,null,"GO:0002218,GO:0003723,GO:0004386,GO:0005741,GO:0008270,GO:0010494,GO:0031048,GO:0031380,GO:0042742,GO:0045071,GO:0045087,GO:0051607","activation of innate immune response|RNA binding|helicase activity|mitochondrial outer membrane|zinc ion binding|cytoplasmic stress granule|regulatory ncRNA-mediated heterochromatin formation|nuclear RNA-directed RNA polymerase complex|defense response to bacterium|negative regulation of viral genome replication|innate immune response|defense response to virus"]
["ZNHIT1",63.6266312380122,60.3878614371729,67.503881199178,74.7972981805949,62.4707454569702,62.0356788329438,73.8229768870107,75.1744459111958,69.4838694803259,72.395873280814,82.9495672947196,76.6549170160222,63.8246099205627,76.8872693230408,70.6259661318802,62.7943512175796,81.555332856049,81.6108785933728,89.7295581412858,75.768983049715,76.7459594616034,89.469611528721,79.3706807845037,79.3309145913935,77.3214578214371,94.9057803434805,94.9666652612635,93.2500915264348,10467,"zinc finger HIT-type containing 1","protein_coding","hsa03082","ATP-dependent chromatin remodeling","GO:0000786,GO:0000812,GO:0003015,GO:0005515,GO:0005634,GO:0005654,GO:0006338,GO:0006355,GO:0031491,GO:0036335,GO:0042393,GO:0042692,GO:0046872,GO:0055074,GO:0060261,GO:1902164,GO:1905458","nucleosome|Swr1 complex|heart process|protein binding|nucleus|nucleoplasm|chromatin remodeling|regulation of DNA-templated transcription|nucleosome binding|intestinal stem cell homeostasis|histone binding|muscle cell differentiation|metal ion binding|calcium ion homeostasis|positive regulation of transcription initiation by RNA polymerase II|positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|positive regulation of lymphoid progenitor cell differentiation"]
["ZNHIT2",5.91418117170461,5.27008116015347,5.08487065468369,5.75165158864436,4.66382611908276,5.08603603714306,6.52464827854467,5.1686126847495,5.23917544663708,6.07585547706797,6.40111619804055,5.05241456238028,4.163980503072,6.09348030736849,5.05628321552075,4.68278956568203,5.62627298069798,5.9714002874536,7.42226942983506,5.20827976263394,6.4243231456562,6.05559889442812,5.49033151319645,6.12264530086045,5.287397653965,6.96033741863291,5.86361050294348,8.48633806543219,741,"zinc finger HIT-type containing 2","protein_coding",null,null,"GO:0005515,GO:0046872","protein binding|metal ion binding"]
["ZNHIT3",10.0414997794378,8.11797164650841,9.51451968630826,8.85836847662886,8.92470281624831,9.89465477534583,10.9669763516159,10.0490613919209,10.7647501794861,9.17427028634104,10.3169448786484,11.2758532724895,11.0607894824176,9.88818847311613,10.5670411350937,10.4015228607263,14.5856236964585,13.3875093689648,16.5485980641248,12.7425046038228,15.2149504477645,14.2926992661621,17.8600088201994,16.4344714165427,15.6543939902125,15.1894827286999,19.6636419309511,15.7756619466443,9326,"zinc finger HIT-type containing 3","protein_coding",null,null,"GO:0000463,GO:0000492,GO:0005515,GO:0005634,GO:0005737,GO:0006355,GO:0046872,GO:0046966,GO:0048254,GO:0070761","maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|box C/D snoRNP assembly|protein binding|nucleus|cytoplasm|regulation of DNA-templated transcription|metal ion binding|nuclear thyroid hormone receptor binding|snoRNA localization|pre-snoRNP complex","WP5287","17q12 copy number variation syndrome"]
["ZNHIT6",7.06506786958074,6.38139702513581,6.7698662870062,6.24098707460787,7.29770426898313,5.81270431508537,6.43555822003688,6.27178107964296,6.8519264643706,4.7801352527885,5.42596672685349,5.87373991206846,6.46589240219084,5.86048907311307,6.31116528891565,6.45065540753898,5.85643072733176,5.77499700986134,5.26101630566414,5.74203726854359,5.77359125509024,5.26402499204122,6.69527807233147,5.52776953148834,5.48194586781647,5.06640252566325,5.549918998415,5.18614929616446,54680,"zinc finger HIT-type containing 6","protein_coding",null,null,"GO:0000463,GO:0000492,GO:0001094,GO:0005515,GO:0005634,GO:0019899,GO:0042802,GO:0046872,GO:0048254,GO:0051117,GO:0051259,GO:0070062,GO:0070761","maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|box C/D snoRNP assembly|TFIID-class transcription factor complex binding|protein binding|nucleus|enzyme binding|identical protein binding|metal ion binding|snoRNA localization|ATPase binding|protein complex oligomerization|extracellular exosome|pre-snoRNP complex"]
["ZNNT1",0.0627801228186157,0.246321540315107,0.250495962048062,0.203208046789384,0.0536778316572617,0.30213789010156,0.248936472488395,0.238552721752888,0.165764269859499,0.1436050994307,0.376386859626503,0.157905049298831,0.111943762774281,0.321710740778353,0.197049925239685,0.223219098228357,0.0980838384847748,0.210569857508684,0.159562503161953,0.0905560462669476,0.199986052550502,0.208861872170594,0.100713928461783,0.0230004229324668,0.0778020894148758,0.238609634876548,0.0683450682836955,0.19181688288036,115830329,"ZNF706 neighboring transcript 1","non_coding"]
["ZNRD2",22.7658059063306,20.226318423259,24.7202796558192,24.9828289387745,17.9066364138579,23.433853055687,26.521187926329,27.2917990160483,21.1378289361441,24.9081370241949,30.3209230145208,27.1831160969283,20.5794712289036,22.1218012403184,25.1272944110744,18.8872619001538,28.7730244361777,27.5746863707833,32.1101026882205,24.1775188725135,25.442670018925,27.1091218174621,28.2788102220116,26.7326551339504,25.7019021866753,28.6143418016352,29.8071448712524,28.8992435221417,10534,"zinc ribbon domain containing 2","protein_coding",null,null,"GO:0000278,GO:0005515,GO:0051301","mitotic cell cycle|protein binding|cell division"]
["ZNRD2-DT",0.112881973346914,0.0429477940704732,0.16956421906298,0.151564535177453,0.154424917707448,0.212003851064031,0.252762868163652,0.177106737822699,0.0454175853048881,0.1304637705751,0.360940497715532,0.227137288250204,0.0214699511518514,0.0430476566777158,0.125975524511133,0.278276070111314,0.108529179614483,0,0.438177294258698,0,0.0852350754402848,0.0429193904586021,0.111439358415869,0.110282597393947,0.156679333331716,0.150161449712274,0.131080574848963,0.0848976926548175,254100,"ZNRD2 divergent transcript","non_coding"]
["ZNRF1",2.27205883181704,2.87836818004084,2.88702719138131,2.80832741380884,2.67950374921262,2.7175543236828,2.53098048715441,2.76095892034909,3.49210492002832,4.20678710031698,4.87674059490745,3.37462882265139,2.98494332313788,3.67868617926211,3.65676855409728,3.25924212470429,2.33980631093432,3.06276954070979,2.84208604220049,2.71694869695517,2.93942563706381,2.98817192708996,2.35904064838843,2.47328707742375,2.85455230078797,2.94517513988417,2.57770367136229,3.01525606242294,84937,"zinc and ring finger 1","protein_coding",null,null,"GO:0004842,GO:0005515,GO:0005737,GO:0005764,GO:0005768,GO:0005829,GO:0005886,GO:0016020,GO:0030672,GO:0034145,GO:0043161,GO:0043231,GO:0046872,GO:0061630,GO:0070936","ubiquitin-protein transferase activity|protein binding|cytoplasm|lysosome|endosome|cytosol|plasma membrane|membrane|synaptic vesicle membrane|positive regulation of toll-like receptor 4 signaling pathway|proteasome-mediated ubiquitin-dependent protein catabolic process|intracellular membrane-bounded organelle|metal ion binding|ubiquitin protein ligase activity|protein K48-linked ubiquitination",null,null,"R-HSA-1280218,R-HSA-168256,R-HSA-983168,R-HSA-983169","Adaptive Immune System|Immune System|Antigen processing: Ubiquitination & Proteasome degradation|Class I MHC mediated antigen processing & presentation"]
["ZNRF2",1.48952878628593,1.11723933131986,0.982891551153595,0.84080065249644,1.23925839729628,1.25487268433095,1.04824360923947,0.817951279053902,1.10443463753879,0.795182242946376,0.600349589896282,0.924843940462276,1.10084513667263,0.649180954508275,1.41691637467984,0.831239164810903,1.08020631137855,0.929306319959006,1.29798831313855,1.51421175406506,1.48623111888257,1.28640268408648,1.9914674307424,1.15586748083889,1.15608696773582,1.31826973097128,1.92734387382912,1.04824658185275,223082,"zinc and ring finger 2","protein_coding",null,null,"GO:0001650,GO:0005654,GO:0005737,GO:0005765,GO:0005829,GO:0005886,GO:0010008,GO:0016020,GO:0016567,GO:0030659,GO:0032991,GO:0042734,GO:0042995,GO:0043161,GO:0043231,GO:0046872,GO:0061630,GO:0070936","fibrillar center|nucleoplasm|cytoplasm|lysosomal membrane|cytosol|plasma membrane|endosome membrane|membrane|protein ubiquitination|cytoplasmic vesicle membrane|protein-containing complex|presynaptic membrane|cell projection|proteasome-mediated ubiquitin-dependent protein catabolic process|intracellular membrane-bounded organelle|metal ion binding|ubiquitin protein ligase activity|protein K48-linked ubiquitination",null,null,"R-HSA-1280218,R-HSA-168256,R-HSA-983168,R-HSA-983169","Adaptive Immune System|Immune System|Antigen processing: Ubiquitination & Proteasome degradation|Class I MHC mediated antigen processing & presentation"]
["ZNRF3",1.61001945985084,1.51298943111124,1.3662031364503,1.19148283572153,1.58837058213376,1.35197884449976,1.36853038620034,1.13095302581066,1.18345250851594,1.28600002424028,1.01184663897396,1.14866571486531,1.21458580801902,1.39474407635799,1.58009300743964,1.40177747845084,0.866993103434557,0.863020016291812,0.794084565921885,0.822496580316574,0.847480178663403,0.985919712249031,0.760334822563133,0.967966111983445,0.847986922440226,0.798000847042375,0.764012493405389,0.658563530165227,84133,"zinc and ring finger 3","protein_coding","hsa04310","Wnt signaling pathway","GO:0004842,GO:0005109,GO:0005515,GO:0005886,GO:0006511,GO:0016055,GO:0016567,GO:0038018,GO:0046872,GO:0060173,GO:0061630,GO:0072089,GO:0090090,GO:2000051,GO:2000095","ubiquitin-protein transferase activity|frizzled binding|protein binding|plasma membrane|ubiquitin-dependent protein catabolic process|Wnt signaling pathway|protein ubiquitination|Wnt receptor catabolic process|metal ion binding|limb development|ubiquitin protein ligase activity|stem cell proliferation|negative regulation of canonical Wnt signaling pathway|negative regulation of non-canonical Wnt signaling pathway|regulation of Wnt signaling pathway, planar cell polarity pathway",null,null,"R-HSA-162582,R-HSA-195721,R-HSA-201681,R-HSA-4641263","Signal Transduction|Signaling by WNT|TCF dependent signaling in response to WNT|Regulation of FZD by ubiquitination"]
["ZNRF3-AS1",0.0993777520193294,0.0354467738157684,0.0932993905811977,0,0,0.0116650966898826,0.0347694544455531,0.0365435676774716,0.0124950683995475,0.0119641890988226,0.0116823788092259,0.0124977844318315,0.0590671006343561,0,0.023105188366558,0.0942252045977766,0,0.0114938417375231,0.0344426391932117,0,0,0.0236155540127054,0.0367903946401516,0.0121361678606795,0.0123156763659031,0,0.0120207531773934,0.0233566463202424,100874123,"ZNRF3 antisense RNA 1","non_coding"]
["ZP1",0.0440461033255606,0.20947576029471,0.237774335371097,0.211213883055414,0.0860799961450485,0.258509597804793,0.369851549739462,0.345531772810952,0.0110761022986185,0.0106055107616197,0.0310671103137504,0,0,0.0944832758698395,0.0204813148510747,0.0104405991614162,0.105869150702363,0.0101885770304024,0.132302131214665,0.127067001195655,0.114325723124254,0.125602333842085,0.0217416003183902,0.150611429578204,0.065502494397083,0.041851720578071,0.0959008617461169,0.144929516995295,22917,"zona pellucida glycoprotein 1","protein_coding",null,null,"GO:0005515,GO:0005576,GO:0005886,GO:0007339,GO:0032190,GO:0035804,GO:0035805,GO:0060468,GO:0062023","protein binding|extracellular region|plasma membrane|binding of sperm to zona pellucida|acrosin binding|structural constituent of egg coat|egg coat|prevention of polyspermy|collagen-containing extracellular matrix","WP5401","7q11.23 distal copy number variation","R-HSA-1187000,R-HSA-1474165,R-HSA-2534343","Fertilization|Reproduction|Interaction With Cumulus Cells And The Zona Pellucida"]
["ZP3",0.563366119545929,1.20161345563354,0.721238560026437,1.22795658419804,0.817405612538858,0.865684629588632,0.891953579105683,0.903984644383814,0.772731747445104,0.953649676996716,0.93118695182342,0.669846419547751,0.519521148581341,0.602203729166602,0.349284893166397,0.776955138608645,0.623709428431707,0.142162589698433,0.55223104216264,0.443245752112521,0.225584154695978,0.53550026056043,0.25280290173885,0.16678584077058,0.507758411285811,0.308202537607226,0.396479306826251,0.449382466883448,7784,"zona pellucida glycoprotein 3","protein_coding",null,null,"GO:0001809,GO:0001825,GO:0002455,GO:0002687,GO:0002922,GO:0005201,GO:0005515,GO:0005576,GO:0005615,GO:0005886,GO:0007165,GO:0007339,GO:0030246,GO:0031012,GO:0032190,GO:0032729,GO:0032753,GO:0035803,GO:0035804,GO:0035805,GO:0042102,GO:0042802,GO:0045892,GO:0045893,GO:0048018,GO:0048599,GO:0050729,GO:0062023,GO:2000344,GO:2000360,GO:2000368,GO:2000386,GO:2000388","positive regulation of type IV hypersensitivity|blastocyst formation|humoral immune response mediated by circulating immunoglobulin|positive regulation of leukocyte migration|positive regulation of humoral immune response|extracellular matrix structural constituent|protein binding|extracellular region|extracellular space|plasma membrane|signal transduction|binding of sperm to zona pellucida|carbohydrate binding|extracellular matrix|acrosin binding|positive regulation of type II interferon production|positive regulation of interleukin-4 production|egg coat formation|structural constituent of egg coat|egg coat|positive regulation of T cell proliferation|identical protein binding|negative regulation of DNA-templated transcription|positive regulation of DNA-templated transcription|receptor ligand activity|oocyte development|positive regulation of inflammatory response|collagen-containing extracellular matrix|positive regulation of acrosome reaction|negative regulation of binding of sperm to zona pellucida|positive regulation of acrosomal vesicle exocytosis|positive regulation of ovarian follicle development|positive regulation of antral ovarian follicle growth","WP5316,WP5401,WP34","Primary ovarian insufficiency|7q11.23 distal copy number variation|Ovarian infertility","R-HSA-1187000,R-HSA-1474165,R-HSA-2534343","Fertilization|Reproduction|Interaction With Cumulus Cells And The Zona Pellucida"]
["ZPLD1",0,0.00627658092045839,0,0,0,0,0,0,0,0,0,0,0,0.012582350568713,0,0,0,0,0.00609877821699464,0,0.00622831579410649,0,0,0,0,0,0,0,131368,"zona pellucida like domain containing 1","protein_coding",null,null,"GO:0005615,GO:0009986,GO:0030659,GO:0060005","extracellular space|cell surface|cytoplasmic vesicle membrane|vestibular reflex"]
["ZPLD2P",0.125028827621721,0,0,0,0.0244345814660341,0,0.0233301534158473,0.0245205757143208,0.0251524104146736,0.0240837572768507,0.0470329536475331,0.025157877752388,0,0.0715198080795816,0,0.0711277924317631,0.0961661153689743,0.0925478165878486,0,0,0,0,0.0493723910755281,0,0.0247912965807141,0,0,0.0705249385643684,101928303,"zona pellucida like domain containing 2%2C pseudogene","non_coding"]
["ZPR1",7.46974491608205,7.46962562768591,7.81787254690361,8.10092291741531,7.12590717743704,7.22738279223485,7.63843280153157,7.70883551650285,6.99523190799506,7.75017445364073,7.40867200070575,7.17094545699978,6.15101787866069,6.9171178810842,6.34491651936369,6.69549764457297,6.7338414112561,6.98777767197109,7.33803614706085,6.7073654486469,6.78574958143527,6.76327942424433,7.00801036181068,7.49508123620315,6.49018628687072,7.52847105888425,7.06876906986395,7.09218368269725,8882,"ZPR1 zinc finger","protein_coding",null,null,"GO:0000226,GO:0001833,GO:0001834,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0006397,GO:0007165,GO:0008270,GO:0008283,GO:0008380,GO:0010628,GO:0015030,GO:0021510,GO:0030424,GO:0030426,GO:0030576,GO:0030971,GO:0031369,GO:0031641,GO:0033120,GO:0042023,GO:0042307,GO:0043025,GO:0043204,GO:0045787,GO:0045927,GO:0048471,GO:0061564,GO:0071364,GO:0071931,GO:0097504,GO:1902742,GO:1990261,GO:2000672","microtubule cytoskeleton organization|inner cell mass cell proliferation|trophectodermal cell proliferation|protein binding|nucleus|nucleoplasm|nucleolus|cytoplasm|mRNA processing|signal transduction|zinc ion binding|cell population proliferation|RNA splicing|positive regulation of gene expression|Cajal body|spinal cord development|axon|growth cone|Cajal body organization|receptor tyrosine kinase binding|translation initiation factor binding|regulation of myelination|positive regulation of RNA splicing|DNA endoreduplication|positive regulation of protein import into nucleus|neuronal cell body|perikaryon|positive regulation of cell cycle|positive regulation of growth|perinuclear region of cytoplasm|axon development|cellular response to epidermal growth factor stimulus|positive regulation of transcription involved in G1/S transition of mitotic cell cycle|Gemini of coiled bodies|apoptotic process involved in development|pre-mRNA catabolic process|negative regulation of motor neuron apoptotic process"]
["ZRANB1",9.0199950298563,9.28940946076362,8.84299746528779,8.16074904319148,9.66025555790543,8.18539523844049,8.32620497998013,8.39098893238986,10.5141172017116,8.00318159566696,9.36859668226041,9.54868479304158,8.89676120919869,9.40233099073579,9.702502841775,10.3346906139262,8.7335747967504,8.97736430303578,8.23687675950146,9.46827888032799,8.5587424167897,9.52606483515032,8.83773841357992,9.45566321066936,8.52715622944792,8.63129461265058,8.49675387457452,8.3072404832726,54764,"zinc finger RANBP2-type containing 1","protein_coding",null,null,"GO:0004843,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0007010,GO:0016055,GO:0016477,GO:0022604,GO:0030177,GO:0031593,GO:0035523,GO:0043231,GO:0046872,GO:0070530,GO:0070536,GO:0071947,GO:0101005,GO:1990168","cysteine-type deubiquitinase activity|protein binding|nucleus|nucleoplasm|cytoplasm|cytosol|cytoskeleton organization|Wnt signaling pathway|cell migration|regulation of cell morphogenesis|positive regulation of Wnt signaling pathway|polyubiquitin modification-dependent protein binding|protein K29-linked deubiquitination|intracellular membrane-bounded organelle|metal ion binding|K63-linked polyubiquitin modification-dependent protein binding|protein K63-linked deubiquitination|protein deubiquitination involved in ubiquitin-dependent protein catabolic process|deubiquitinase activity|protein K33-linked deubiquitination",null,null,"R-HSA-162582,R-HSA-195253,R-HSA-195721,R-HSA-392499,R-HSA-5688426,R-HSA-5689896,R-HSA-597592","Signal Transduction|Degradation of beta-catenin by the destruction complex|Signaling by WNT|Metabolism of proteins|Deubiquitination|Ovarian tumor domain proteases|Post-translational protein modification"]
["ZRANB2",21.8465625375906,21.0635086536396,20.1426720022621,17.2767842201725,23.6800084587271,20.0509737049581,19.4605113594493,17.3356314270466,22.1247423000124,13.5064976402785,15.301653309566,19.8499919513418,25.6351216753105,17.8056037448296,22.84056962328,22.3759194247764,20.887606244973,18.0483928416912,23.956954363769,25.6257792601541,24.3777917510973,21.2622897865725,42.7389174474652,29.4327048206664,23.3508802302279,19.5178126410571,32.292749256141,19.3023170836851,9406,"zinc finger RANBP2-type containing 2","protein_coding",null,null,"GO:0001530,GO:0003723,GO:0005515,GO:0005654,GO:0006397,GO:0008380,GO:0046872","lipopolysaccharide binding|RNA binding|protein binding|nucleoplasm|mRNA processing|RNA splicing|metal ion binding"]
["ZRANB2-AS1",0.369483283915727,0.152799958641671,0.0603276750778304,0.415983099357291,0.188370527916935,0.316792882096515,0.179856295940048,0.0945167364244499,0.274697898247502,0.0773608174745085,0.181292696181313,0.630326279181108,0.22915782188895,0.153155250516068,0.0896393183946919,0.335094701094893,0.26256558853573,0.044591722116374,0.504802924051481,0.0463438645600365,0.0606499881261621,0.137429013667502,0.523353230071763,0.39236418739086,0.191120508085887,0.167905710924656,0.373087500285251,0.0755123994560877,100132618,"ZRANB2 antisense RNA 1","non_coding"]
["ZRANB2-DT",0.103280518142693,0.0327456360920466,0.161605745179756,0.297156083746928,0.0672809165271643,0.0646571131980724,0.160599651227863,0.0675177027331745,0.519431004349007,0.03315745893288,0.161882260638699,0.519543912204489,0.458354665969793,0.22975243583164,0.192100608258356,0.359060605643187,0.165496603396798,0.159269709900544,0.190908115068376,0.165527894277865,0.0324938314417944,0.490859695474817,0.441829303021999,0.538145272187475,0.477841951463778,0.228981827530595,0.49971330258513,0.161826061669623,100852410,"ZRANB2 divergent transcript","non_coding"]
["ZRANB3",0.972567992862464,0.662847956950739,0.607522825068228,0.521458275370675,0.729601330962364,0.59687516045874,0.582306047913665,0.585735252375838,0.616234055159504,0.490480769291363,0.439317182663989,0.681857105457693,0.739194559671597,0.697243628975838,0.537704337504977,0.595398895814217,1.11545180850247,0.758169066203266,1.14658763086947,0.898421456181102,1.02276642263576,0.866227913735928,1.44398815023708,1.26440251123494,1.01357666614213,0.727649232777825,1.38947271279885,1.14830761947879,84083,"zinc finger RANBP2-type containing 3","protein_coding",null,null,"GO:0003678,GO:0004520,GO:0005515,GO:0005524,GO:0005654,GO:0006281,GO:0006338,GO:0006974,GO:0008270,GO:0009411,GO:0031297,GO:0036292,GO:0036310,GO:0043596,GO:0045910,GO:0070530,GO:0071932,GO:0140658","DNA helicase activity|DNA endonuclease activity|protein binding|ATP binding|nucleoplasm|DNA repair|chromatin remodeling|DNA damage response|zinc ion binding|response to UV|replication fork processing|DNA rewinding|ATP-dependent DNA/DNA annealing activity|nuclear replication fork|negative regulation of DNA recombination|K63-linked polyubiquitin modification-dependent protein binding|replication fork reversal|ATP-dependent chromatin remodeler activity"]
["ZRSR2",3.69145622648233,3.42953181058295,4.4961615154486,5.01055449309766,3.24162853544772,3.95591662745909,4.11346268650177,3.99864993455986,3.44788280725731,3.38407469685328,4.84986143209124,3.53500230672966,2.85158655578409,4.05134658060993,3.80371003069523,3.17447415012334,3.72597757827688,3.96592446831829,3.74042674040929,3.9212714700188,3.57100259364802,3.58463803544769,4.21937397552949,3.37281110943375,3.90297119481217,3.60077123524925,3.76797016396481,4.30628868501476,8233,"zinc finger CCCH-type%2C RNA binding motif and serine/arginine rich 2","protein_coding",null,null,"GO:0000245,GO:0000398,GO:0005515,GO:0005654,GO:0005681,GO:0005689,GO:0008380,GO:0030628,GO:0042802,GO:0046872,GO:0089701","spliceosomal complex assembly|mRNA splicing, via spliceosome|protein binding|nucleoplasm|spliceosomal complex|U12-type spliceosomal complex|RNA splicing|pre-mRNA 3'-splice site binding|identical protein binding|metal ion binding|U2AF complex",null,null,"R-HSA-72165,R-HSA-72172,R-HSA-72203,R-HSA-8953854","mRNA Splicing - Minor Pathway|mRNA Splicing|Processing of Capped Intron-Containing Pre-mRNA|Metabolism of RNA"]
["ZSCAN1",0.0409047272158469,0.0833725332540837,0.0630903504214662,0.0364278702273765,0.0770857281758498,0.046642685550593,0.0381637410960295,0.0171904491350777,0.0646558167563841,0.0844210611677165,0.065946053369227,0.0911257271547046,0.0805786395603735,0.161561690886905,0.0978201449813308,0.124662519360677,0.0252819112104321,0.0405511108342052,0.0378050212692308,0.0168577942188903,0.0496388532777639,0.0222179719087669,0.0201909854246659,0.0371083129579199,0.0463473101478601,0.0721812895987715,0.0226187161456265,0.0824039494606429,284312,"zinc finger and SCAN domain containing 1","protein_coding",null,null,"GO:0000785,GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872,GO:1990837","chromatin|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding|sequence-specific double-stranded DNA binding"]
["ZSCAN10",0,0,0,0.00897659002985513,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,84891,"zinc finger and SCAN domain containing 10","protein_coding",null,null,"GO:0000978,GO:0000981,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0043565,GO:0045892,GO:0046872","RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|regulation of transcription by RNA polymerase II|sequence-specific DNA binding|negative regulation of DNA-templated transcription|metal ion binding",null,null,"R-HSA-1266738,R-HSA-452723","Developmental Biology|Transcriptional regulation of pluripotent stem cells"]
["ZSCAN12",1.22807358702702,1.30221711821173,0.939448432115578,0.883345533689616,1.32002399555459,1.21942726360692,1.0672743109161,0.885343179461319,1.45945519247765,0.96594702116766,0.943194638409261,1.13258205917926,1.30630334024192,1.20550871309774,1.17171160678768,1.27868404126028,1.29879020050717,1.02055966731259,1.11189118954592,1.33840048639797,1.30508254209958,1.05275800747013,1.69059514457532,1.38865077710677,1.29420063847478,0.974569906369234,1.32702908463267,1.04976824242085,9753,"zinc finger and SCAN domain containing 12","protein_coding",null,null,"GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872","RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding"]
["ZSCAN16",0.367177682606301,0.511093017808754,0.45402087160734,0.858889677275175,0.463802450990165,0.378437439125263,0.392706163776519,0.324926140512092,0.558500499161172,0.465768663986722,0.496908624234286,0.603672052672419,0.366216023933008,0.4525152508105,0.558017165550478,0.399087567148141,0.602715537021827,0.480602963815502,0.488337884375071,0.499487295065448,0.600142714732118,0.808695425202531,0.77801702773902,0.647450443544159,0.435058427902486,0.663732137380331,0.840614065219119,0.623024961146932,80345,"zinc finger and SCAN domain containing 16","protein_coding",null,null,"GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872,GO:1990837","RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding|sequence-specific double-stranded DNA binding",{"$nulls":4},"zf-C2H2"]
["ZSCAN16-AS1",1.86202584653326,1.1729109359594,2.39645203883624,2.57816206969087,2.06048576316825,1.07691361527228,3.3709617003701,2.90208753376444,2.95205993853171,1.66272673752164,2.73686177300128,2.3075735372259,2.57992990327919,2.43357107254137,2.47709604098195,2.38515631126165,2.85724661946806,3.19472014625757,3.90911875234818,2.84592880994478,2.45581124153393,2.64902561731725,2.61734654153137,3.46963379058109,3.49650277502599,2.34339002687826,4.61798184393561,3.1416612537843,100129195,"ZSCAN16 antisense RNA 1","non_coding"]
["ZSCAN18",14.0141443507436,17.2128691558234,16.675707613317,17.8738958919632,16.2752815364897,17.2674607215225,17.324067818213,17.2324489629199,15.6836762775434,20.6343624818402,19.8579624828005,17.0935732682228,16.8916121506739,19.5014924347064,16.9573557292469,18.4756949059871,12.2698539359862,14.5063034205336,14.5057974864951,13.3360921254879,13.6158354985147,15.37535613482,12.6496684288343,13.2389644057034,13.4772997380546,14.1390372078292,12.8142835207741,15.7470093337019,65982,"zinc finger and SCAN domain containing 18","protein_coding",null,null,"GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872","RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding"]
["ZSCAN2",1.42936527225578,1.51854474185163,1.66660200686469,1.46481366491029,1.6332561167226,1.87265082247117,1.98962261950927,1.54292459039348,1.91892939477079,2.14270773422189,2.40661499574792,2.16868759657596,2.15955483003471,2.22541750477261,2.63716306475006,2.62853971036511,2.00595895858066,1.87715545708566,1.77915587160259,2.11718564660574,1.82782491476562,1.94486230849772,1.87198107372556,1.90322721383237,2.10280233456395,2.03175472753734,2.32015700412585,1.69596619063201,54993,"zinc finger and SCAN domain containing 2","protein_coding",null,null,"GO:0000977,GO:0000981,GO:0005634,GO:0006357,GO:0007283,GO:0030154,GO:0046872","RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|spermatogenesis|cell differentiation|metal ion binding","WP5408","15q25 copy number variation",null,null,"zf-C2H2"]
["ZSCAN20",0.823882512283862,0.818477804272182,0.756301716042514,0.706258674932138,0.850782954880742,0.811873475378785,0.635817546076896,0.823855074792515,0.80620583957778,0.846404756531603,0.705941527727078,0.810474388194207,0.63647687202303,0.835896415121351,0.78134106354211,0.734874466128063,0.598485475521334,0.698313121094842,0.71820696130659,0.954627884916604,0.758422357367397,0.715452732503254,0.783229215001643,0.794973489024967,0.772445987809657,0.68812301454875,0.883871439387953,0.678922062214125,7579,"zinc finger and SCAN domain containing 20","protein_coding",null,null,"GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872","RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding"]
["ZSCAN21",3.55849218133801,3.61898084779851,3.73950806459524,3.7711859512949,3.87555249184616,3.83606741398828,3.87470186891512,3.60603881804548,3.65624440036666,4.16345487880357,4.21713999510357,4.09280783616213,3.30332853345999,4.50995407289986,4.4704244573998,4.23560700346543,4.06633601442514,3.91333806303457,4.33278417676924,3.90376730327371,4.42481217720435,3.94756975890078,4.67004642907003,3.81673684893834,3.46061193461186,3.93801747352374,4.14204704948067,4.07195974836362,7589,"zinc finger and SCAN domain containing 21","protein_coding",null,null,"GO:0000978,GO:0000981,GO:0001228,GO:0005515,GO:0005634,GO:0006355,GO:0006357,GO:0007141,GO:0007283,GO:0030154,GO:0045944,GO:0046872","RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|protein binding|nucleus|regulation of DNA-templated transcription|regulation of transcription by RNA polymerase II|male meiosis I|spermatogenesis|cell differentiation|positive regulation of transcription by RNA polymerase II|metal ion binding"]
["ZSCAN22",0.609620239123845,0.723722545140629,0.710037553086164,0.637412684316868,0.568821766738458,0.589681447871997,0.62436425536701,0.489919518378528,0.64546876037792,0.635703079340263,0.844881713167827,0.673278024773483,0.688717773286697,0.769104469042842,0.652198060668334,0.569320670613202,0.612554117459524,0.720979122083367,0.588841651637955,0.736085461100765,0.51049737497588,0.662247435431965,0.533953888315888,0.568713909322338,0.699821922795021,0.609735660453855,0.643144020960185,0.723932918084304,342945,"zinc finger and SCAN domain containing 22","protein_coding",null,null,"GO:0000978,GO:0000981,GO:0003674,GO:0005515,GO:0005634,GO:0006357,GO:0008150,GO:0046872","RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|molecular_function|protein binding|nucleus|regulation of transcription by RNA polymerase II|biological_process|metal ion binding",{"$nulls":4},"zf-C2H2"]
["ZSCAN23",0.417090256595382,0.505932032739609,0.290384620980509,0.204501452975002,0.650269122478207,0.400470556910836,0.251411606307597,0.287217278990327,0.681157184058437,0.334007212358994,0.158662627360349,0.379550673413505,0.684108340952742,0.379772833468478,0.39007077178469,0.575423675896301,0.317651625605297,0.190791378494212,0.160257272880329,0.351510800247787,0.356073528602827,0.229412051346479,0.395567099534105,0.464716907537199,0.32291181000064,0.162531942676104,0.324248949798067,0.149796015777771,222696,"zinc finger and SCAN domain containing 23","protein_coding",null,null,"GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872,GO:1990837","RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding|sequence-specific double-stranded DNA binding"]
["ZSCAN25",1.67615817585344,1.76512286223017,1.38536282808226,1.42094456435281,1.57937581201508,1.50373018011539,1.30413122513062,1.26207724479416,1.85458670120399,1.74408013084491,1.50595799229079,1.62913879518512,1.68794438745937,1.47816074138984,1.66459464444524,1.64317363164535,1.33814092413407,1.2933315876514,1.44955348929666,1.48806378881894,1.6611470098965,1.43961529075232,1.81430105894756,1.4913498746851,1.55198581661416,1.40210234576207,1.44241029632267,1.32253184443788,221785,"zinc finger and SCAN domain containing 25","protein_coding",null,null,"GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872","RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding",null,null,"R-HSA-212436,R-HSA-73857,R-HSA-74160","Generic Transcription Pathway|RNA Polymerase II Transcription|Gene expression (Transcription)"]
["ZSCAN26",4.77131975094096,5.06005749344454,5.78736481400714,4.66782681552466,4.60277746829076,5.31447638277761,6.26310628221594,4.86657395136355,4.82557442935627,4.02516129371241,4.7082326095645,4.53755154019525,4.55404293327545,4.10062300131737,5.2713188710894,4.8954269835459,5.60023186482781,4.43084628996571,7.03307715773702,5.76037072086972,5.85937458769171,4.73394222589318,7.84770647771477,6.38822631702636,5.35190923213375,5.90693237647239,6.3527506246084,5.3859853060112,7741,"zinc finger and SCAN domain containing 26","protein_coding",null,null,"GO:0000978,GO:0000981,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006355,GO:0006357,GO:0046872","RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription factor activity|protein binding|nucleus|nucleoplasm|cytosol|regulation of DNA-templated transcription|regulation of transcription by RNA polymerase II|metal ion binding"]
["ZSCAN29",3.8714841135405,4.08978932246555,4.38710407174062,3.24529782447919,4.18497461201647,3.38067603974697,3.61205971590762,3.45124113805747,4.08185993309051,3.33258280966921,3.51329578985589,3.34469572096685,3.59303026784673,3.51714997669322,4.27086158818088,3.99239840174876,3.36343144185139,3.49975457304062,2.68456090549785,3.61688213502462,2.93769384833899,3.09957396945273,3.46617951201504,3.09463689483764,3.38844805371904,3.1104972960827,3.04058683131246,2.75066120302808,146050,"zinc finger and SCAN domain containing 29","protein_coding",null,null,"GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872,GO:1990837","RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding|sequence-specific double-stranded DNA binding",{"$nulls":4},"zf-C2H2"]
["ZSCAN30",5.00480366160695,5.56972261344407,5.08701020176511,4.72622777827918,5.61221951192767,4.92171447999106,4.63635914653669,4.22977243591135,5.67605326562963,4.3080784284842,4.23994551035149,4.52994004151921,4.95057917491201,4.36023128065006,4.79181955663479,5.05905388703938,4.43686889079439,4.49955433964488,4.59277972003767,4.64794489774692,4.48955488058628,4.19559150581493,4.85334283933328,4.68173558372952,5.51254749427516,4.24454609015722,4.71726290570553,4.47178404477373,100101467,"zinc finger and SCAN domain containing 30","protein_coding",null,null,"GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872","RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding"]
["ZSCAN31",0.135999404171922,0.212901703988409,0.172901500965392,0.12499670455699,0.182727727784885,0.204868720402826,0.195616249557386,0.150030665701286,0.28784361374068,0.185561881797589,0.181191067594007,0.168182819088436,0.239807213485667,0.218799194236315,0.274037151070255,0.166557954416975,0.542089221178871,0.327696507389441,0.374462033776383,0.435933037526403,0.379741343566045,0.401283218358632,0.497885846601673,0.539775008434574,0.469106365171289,0.368826535647234,0.537383512866195,0.428847568052506,64288,"zinc finger and SCAN domain containing 31","protein_coding",null,null,"GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872,GO:1990837","RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding|sequence-specific double-stranded DNA binding",{"$nulls":4},"other"]
["ZSCAN32",2.66438826397058,2.7707268168487,2.32787936188538,2.21296611528157,2.53501415935129,2.78332130880257,2.52153224925235,2.21891206434462,2.56460614112255,3.13708450366787,2.78744486579557,2.64853142247616,2.85508212557845,2.5644758423844,3.28998978591442,2.94325650174049,2.98450367953986,2.57732210481811,3.33436890595779,3.15669405193085,3.12242746271508,3.0354837852912,3.04565426678162,2.98290304077231,2.90063445985588,2.77996763399025,3.11490715758964,3.67335593540431,54925,"zinc finger and SCAN domain containing 32","protein_coding","hsa05168","Herpes simplex virus 1 infection","GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0042802,GO:0046872","RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|identical protein binding|metal ion binding",null,null,"R-HSA-212436,R-HSA-73857,R-HSA-74160","Generic Transcription Pathway|RNA Polymerase II Transcription|Gene expression (Transcription)"]
["ZSCAN4",0,0,0,0,0.00813228737893944,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.00825100886508486,0,0,0,201516,"zinc finger and SCAN domain containing 4","protein_coding",null,null,"GO:0000781,GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0010833,GO:0045950,GO:0046872,GO:1990837","chromosome, telomeric region|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|telomere maintenance via telomere lengthening|negative regulation of mitotic recombination|metal ion binding|sequence-specific double-stranded DNA binding","WP3527","Pre-implantation embryo"]
["ZSCAN5A",0.798045845780223,0.958426774075678,0.946002530470614,0.773103447547332,0.669539682934423,0.756975472997768,0.812257709714896,0.418946941645336,0.737859197625196,0.70650969537814,1.00068797431659,0.81912063813532,0.743602512710862,0.576393190115049,0.817145664524818,0.557947617386879,0.829274577104494,0.701110597374392,1.06538031978125,0.8526864553919,0.66193549391342,0.574675749935379,0.899259636135524,0.79541982955297,0.823168906860949,0.857860148117015,1.13888009020986,0.727520418874537,79149,"zinc finger and SCAN domain containing 5A","protein_coding",null,null,"GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872,GO:1990837","RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding|sequence-specific double-stranded DNA binding",{"$nulls":4},"zf-C2H2"]
["ZSCAN5A-AS1",0,0,0.115691244320685,0.029545804898266,0.0301034043661541,0,0,0,0,0.0593423779301601,0,0,0,0,0,0,0.0592383270672882,0,0,0,0,0.0585665739515096,0,0.12039078517794,0,0.0292722891357479,0,0,112268243,null,"non_coding"]
["ZSCAN5B",0,0.026805889242104,0,0.0135141554030228,0.0137691995924646,0.0132322320005464,0.0262936804833073,0,0.0141737053983367,0.0542860226752641,0.0132518358682803,0.0283535726263192,0.0134004817957713,0.0537364370864534,0,0,0.0541908376203629,0,0,0,0,0.0133940805560823,0,0,0,0.0133890501797069,0.0545426751593179,0,342933,"zinc finger and SCAN domain containing 5B","protein_coding",null,null,"GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872","RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding",{"$nulls":4},"zf-C2H2"]
["ZSCAN5C",0,0,0,0,0,0,0,0.0137030485329382,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,649137,"zinc finger and SCAN domain containing 5C","protein_coding",null,null,"GO:0000978,GO:0000981,GO:0005634,GO:0006357,GO:0046872","RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|nucleus|regulation of transcription by RNA polymerase II|metal ion binding"]
["ZSCAN9",2.18174049730061,2.65831045104431,2.22604076917204,2.88788009415326,2.11428592538206,2.48053014260678,2.44769982148645,2.08636475796954,2.61167824313753,2.67437639668531,3.38292777404418,3.46485398893725,2.8207207462131,3.17160449247627,3.03512536278696,2.82939538906542,2.20162511550247,2.41908849679709,2.64966416963965,2.08066902292284,2.79954462750044,2.33947999208475,3.29308894722159,2.56308559163321,2.35966711588582,2.24437200146161,3.13194894574743,3.20376633957225,7746,"zinc finger and SCAN domain containing 9","protein_coding",null,null,"GO:0000978,GO:0000981,GO:0005515,GO:0005634,GO:0006357,GO:0046872,GO:1990837","RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|protein binding|nucleus|regulation of transcription by RNA polymerase II|metal ion binding|sequence-specific double-stranded DNA binding"]
["ZSWIM1",2.43753010105921,2.24629325933051,2.32011442136386,2.10315100574328,2.34888500119201,2.62953762805352,2.39223130044248,2.76241624752585,2.68937190280499,2.94878329006056,2.78414188598972,2.68147081996104,1.90097742085375,2.82243658130329,2.15707464920893,2.13521359871346,2.64357521838923,1.982220178,2.1280938552827,2.29531668117259,2.90568665735532,2.5173914570052,1.72360005928344,2.43908114526648,2.33300373661099,2.95722476680369,2.26081180456803,3.05277067713494,90204,"zinc finger SWIM-type containing 1","protein_coding",null,null,"GO:0005634,GO:0008270","nucleus|zinc ion binding"]
["ZSWIM2",0.021996095663193,0.0209219364015279,0.0516268047636676,0,0.0107468293840819,0.0413109095341417,0,0,0.0110625452578613,0.0423701188811833,0,0,0.0209180919423178,0.0209705842811883,0.0102281229611242,0,0.0105739567898566,0.0203522126237659,0,0.021151912071737,0.0311415789705324,0,0,0.0107447916187982,0.010903719997556,0,0.0106426088922659,0.0103394374775451,151112,"zinc finger SWIM-type containing 2","protein_coding",null,null,"GO:0006915,GO:0008270,GO:0043621,GO:0061630,GO:1902043","apoptotic process|zinc ion binding|protein self-association|ubiquitin protein ligase activity|positive regulation of extrinsic apoptotic signaling pathway via death domain receptors"]
["ZSWIM3",1.28177968697841,1.2284213966101,1.29454584895939,1.53662665064378,1.55613779774607,1.77812884161521,1.54921967592596,1.73301112134253,1.04511164686273,2.02012057435163,1.44287478333257,1.90505672994578,1.51446684248952,1.8330300090944,1.57133591920839,1.80456880491383,1.57778595372392,1.75202418272079,1.45388633309097,1.6714620373417,1.56725380880265,1.75372711084986,1.73513007958841,1.7835270318598,1.60773701665693,1.59621497403596,1.29673441876882,1.80753181879599,140831,"zinc finger SWIM-type containing 3","protein_coding",null,null,"GO:0005515,GO:0008270","protein binding|zinc ion binding"]
["ZSWIM4",0.894079035607865,1.6804657219114,1.50789233536146,1.43768067528801,1.2241652520298,1.10604114394239,1.2037988474936,0.992228627048093,1.26551343204553,2.3306763129472,1.70683382789094,1.76133125223104,1.16083569850462,1.69458147848063,1.59825035357431,1.70559784449679,1.33315649172037,1.53067839131308,1.26175666319521,1.53934037833767,1.40477900005186,1.53686367097183,0.97250372538363,1.0617881438546,1.4808897601209,1.24632512084924,0.984340920563917,1.58041228100166,65249,"zinc finger SWIM-type containing 4","protein_coding",null,null,"GO:0008270,GO:0031462","zinc ion binding|Cul2-RING ubiquitin ligase complex"]
["ZSWIM5",0.167429908293435,0.0774747347794704,0.0679737040662075,0.0911371772713846,0.0972789212772312,0.131729235240625,0.0675505264590457,0.137557260235214,0.0637233805570345,0.0871656550090484,0.085112513063691,0.0865005291462838,0.0559436934327744,0.0647123997899857,0.0883753092046375,0.137296420330485,0.0217532047103731,0.0376825128645,0,0.0217573176463939,0.0341684338008058,0.0129039161174007,0.0178692085208727,0.039788376417504,0.0403768943135955,0.00859937988711749,0.0350311020915814,0.0212707413609728,57643,"zinc finger SWIM-type containing 5","protein_coding",null,null,"GO:0005615,GO:0008270,GO:0031462","extracellular space|zinc ion binding|Cul2-RING ubiquitin ligase complex"]
["ZSWIM6",5.10825413587293,5.24952698887614,3.69595326435447,3.31957769863755,5.61598186787096,4.6183215667334,3.76521089468078,3.27477530469778,5.97226186603293,5.35950765823665,3.58423360237793,5.30005167498913,6.57245888020873,4.804821874346,6.04885159247827,6.46267637235604,3.80322263519347,3.57917939778784,3.26578945622366,4.58667588230109,4.55218083589627,3.33708404738168,4.82893613144724,4.42578830970656,4.71373954317939,3.29607545228261,4.01563038307939,2.78200167324767,57688,"zinc finger SWIM-type containing 6","protein_coding",null,null,"GO:0008270,GO:0021773,GO:0031462","zinc ion binding|striatal medium spiny neuron differentiation|Cul2-RING ubiquitin ligase complex"]
["ZSWIM7",6.63229652075041,6.30841437171091,7.7676361440559,7.57659749371376,5.38545433307868,5.77693701765243,7.48271937363978,6.75223821779184,5.48997428547051,4.94825830822344,6.71418696958955,6.10875616770734,4.78437666910499,5.83962773554342,6.52790200627641,5.6810918066678,7.69804992829859,6.5440927635274,9.01573024307193,7.32736265706671,6.86448275263076,8.15619273996735,7.68051091802016,6.90980527552848,8.0571959345703,8.36868662172992,9.07810850477499,9.37150745511133,125150,"zinc finger SWIM-type containing 7","protein_coding",null,null,"GO:0000724,GO:0005515,GO:0005634,GO:0008270,GO:0050821,GO:0097196","double-strand break repair via homologous recombination|protein binding|nucleus|zinc ion binding|protein stabilization|Shu complex"]
["ZSWIM8",15.9794501124233,18.8361427148935,16.2871431846427,16.7607713044913,18.2161345748836,18.6293982568361,15.2712038087018,17.2151230377183,18.6891020116122,25.417954035831,19.7449424055981,18.0756858527887,17.5855674981491,20.4416927491747,17.4559981956869,19.6932992724945,13.2873847875131,13.9681335682692,11.4997982650745,13.0436306052912,13.8153073075735,12.2385432790562,10.0910940209955,12.0785185784584,13.6886372467991,11.9696332172404,10.1947407152065,12.1251218399753,23053,"zinc finger SWIM-type containing 8","protein_coding",null,null,"GO:0005829,GO:0008270,GO:0016567,GO:0031462,GO:0031463,GO:0043161,GO:0140958,GO:1990756,GO:2000627","cytosol|zinc ion binding|protein ubiquitination|Cul2-RING ubiquitin ligase complex|Cul3-RING ubiquitin ligase complex|proteasome-mediated ubiquitin-dependent protein catabolic process|target-directed miRNA degradation|ubiquitin ligase-substrate adaptor activity|positive regulation of miRNA catabolic process",null,null,"R-HSA-1266738,R-HSA-376176,R-HSA-422475,R-HSA-9010553,R-HSA-9675108","Developmental Biology|Signaling by ROBO receptors|Axon guidance|Regulation of expression of SLITs and ROBOs|Nervous system development"]
["ZSWIM8-AS1",2.91717945696466,1.73859141982683,2.44407658699735,2.86857386597891,2.9587935113309,1.64709567302692,1.91208184755716,2.71573773493539,3.08285858827741,2.79183533156019,2.67398448662132,3.78939672074189,2.07187969704564,2.76357110462029,1.33930965168617,2.25825869204243,1.73961868014382,1.46916489387436,1.19448330900658,1.50913821967991,0.958456747288271,1.28114380518927,1.73158444179617,1.58734425662696,2.17827199175833,1.31574929762565,2.00104373440664,1.30181307829433,100507331,"ZSWIM8 antisense RNA 1","non_coding"]
["ZSWIM9",3.51133064186533,4.1848135455429,4.41795778245324,4.89880760907845,3.86514708141474,3.90605412006511,4.49125453497914,4.29664258575542,3.69493445498444,4.34728174994938,4.53276818055318,4.28149995143747,3.81301743021764,4.61228179369776,4.38751629723544,4.11464222181857,3.39901500916317,4.69842452428851,3.60582962829548,4.184638048728,3.85237488596504,3.93671443144332,3.11092237020654,3.39528955359465,3.8680163692065,4.40290165023329,3.35719213544366,4.34498111072067,374920,"zinc finger SWIM-type containing 9","protein_coding",null,null,"GO:0005515","protein binding"]
["ZUP1",3.53097255206623,2.76410874179298,3.84305705571634,3.88587841663342,4.38668716058186,3.38423025374718,3.20690447301141,3.43181943134957,3.75074143619494,2.96941187865368,3.66351815842025,4.01353694711726,3.69470648566106,3.60467570567406,3.69062530637929,3.59479349921231,4.6365779082564,3.95134118774124,5.08281791370611,4.90788927338398,4.77787389072548,3.05930012212894,6.20048934706141,5.73926318443913,5.01868570672673,4.18640108824138,5.95682199668152,4.64145658270382,221302,"zinc finger containing ubiquitin peptidase 1","protein_coding",null,null,"GO:0004843,GO:0005515,GO:0005654,GO:0005829,GO:0046872","cysteine-type deubiquitinase activity|protein binding|nucleoplasm|cytosol|metal ion binding"]
["ZW10",11.0613434930825,9.30107047558493,8.70053010898773,8.37980156166338,9.67331377369305,8.33591831906149,7.78779828734157,8.77763894382635,8.62047694817613,7.60068431118409,8.79409192693672,9.48271548555634,8.2651168160053,6.92998990021322,7.66769577863229,7.36792362779821,9.21385789751334,9.07359537303399,9.38122477446002,10.4938063856395,9.99282798329503,10.2138085434399,10.5529229683331,10.6250057177514,9.99884283437955,9.37091773324138,10.3350705240656,9.47265034589308,9183,"zw10 kinetochore protein","protein_coding",null,null,"GO:0000070,GO:0000132,GO:0000776,GO:0000922,GO:0005515,GO:0005634,GO:0005783,GO:0005789,GO:0005811,GO:0005828,GO:0005829,GO:0006888,GO:0006890,GO:0007030,GO:0007080,GO:0007094,GO:0007096,GO:0015031,GO:0016020,GO:0019237,GO:0034501,GO:0051301,GO:0051321,GO:0051988,GO:0065003,GO:0070939,GO:1990423","mitotic sister chromatid segregation|establishment of mitotic spindle orientation|kinetochore|spindle pole|protein binding|nucleus|endoplasmic reticulum|endoplasmic reticulum membrane|lipid droplet|kinetochore microtubule|cytosol|endoplasmic reticulum to Golgi vesicle-mediated transport|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|Golgi organization|mitotic metaphase chromosome alignment|mitotic spindle assembly checkpoint signaling|regulation of exit from mitosis|protein transport|membrane|centromeric DNA binding|protein localization to kinetochore|cell division|meiotic cell cycle|regulation of attachment of spindle microtubules to kinetochore|protein-containing complex assembly|Dsl1/NZR complex|RZZ complex",null,null,"R-HSA-141424,R-HSA-141444,R-HSA-162582,R-HSA-1640170,R-HSA-194315,R-HSA-195258,R-HSA-199991,R-HSA-2467813,R-HSA-2500257,R-HSA-2555396,R-HSA-5653656,R-HSA-5663220,R-HSA-6811434,R-HSA-6811442,R-HSA-68877,R-HSA-68882,R-HSA-68886,R-HSA-69278,R-HSA-69618,R-HSA-69620,R-HSA-8856688,R-HSA-9648025,R-HSA-9716542","Amplification of signal from the kinetochores|Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal|Signal Transduction|Cell Cycle|Signaling by Rho GTPases|RHO GTPase Effectors|Membrane Trafficking|Separation of Sister Chromatids|Resolution of Sister Chromatid Cohesion|Mitotic Metaphase and Anaphase|Vesicle-mediated transport|RHO GTPases Activate Formins|COPI-dependent Golgi-to-ER retrograde traffic|Intra-Golgi and retrograde Golgi-to-ER traffic|Mitotic Prometaphase|Mitotic Anaphase|M Phase|Cell Cycle, Mitotic|Mitotic Spindle Checkpoint|Cell Cycle Checkpoints|Golgi-to-ER retrograde transport|EML4 and NUDC in mitotic spindle formation|Signaling by Rho GTPases, Miro GTPases and RHOBTB3"]
["ZWILCH",12.8352493681089,8.13665162963277,5.3152523749976,7.32840052388563,9.19418339313162,5.87898744260376,4.23936074465591,5.43706885924355,8.84705021846339,5.74829030119556,4.63046438991808,7.65833070194891,7.46127931687901,3.45445195505468,3.51239563367992,3.12382726909573,14.4895101825662,11.4096158620264,12.902361986554,12.6657907435708,14.6933143117423,12.7489432321273,17.7627814035379,15.5871809264935,14.180917258545,11.501669433792,16.1882733778919,11.3455067743438,55055,"zwilch kinetochore protein","protein_coding",null,null,"GO:0000776,GO:0005515,GO:0005828,GO:0005829,GO:0007094,GO:0034501,GO:0051301,GO:0051988,GO:1990423","kinetochore|protein binding|kinetochore microtubule|cytosol|mitotic spindle assembly checkpoint signaling|protein localization to kinetochore|cell division|regulation of attachment of spindle microtubules to kinetochore|RZZ complex",null,null,"R-HSA-141424,R-HSA-141444,R-HSA-162582,R-HSA-1640170,R-HSA-194315,R-HSA-195258,R-HSA-2467813,R-HSA-2500257,R-HSA-2555396,R-HSA-5663220,R-HSA-68877,R-HSA-68882,R-HSA-68886,R-HSA-69278,R-HSA-69618,R-HSA-69620,R-HSA-9648025,R-HSA-9716542","Amplification of signal from the kinetochores|Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal|Signal Transduction|Cell Cycle|Signaling by Rho GTPases|RHO GTPase Effectors|Separation of Sister Chromatids|Resolution of Sister Chromatid Cohesion|Mitotic Metaphase and Anaphase|RHO GTPases Activate Formins|Mitotic Prometaphase|Mitotic Anaphase|M Phase|Cell Cycle, Mitotic|Mitotic Spindle Checkpoint|Cell Cycle Checkpoints|EML4 and NUDC in mitotic spindle formation|Signaling by Rho GTPases, Miro GTPases and RHOBTB3"]
["ZWINT",30.5661995739758,20.9942469958981,9.74536561940201,20.9647885776042,19.5173427404056,16.1521588359923,6.36322907262593,13.8290365709095,17.6657569918385,18.2746612758165,10.5843542986257,17.0035310795651,11.736561730865,4.98983780553006,3.99619115196206,3.96762120495561,28.727020053715,25.1612339266986,20.3764334633859,27.0267625342011,30.0761127054113,25.9315854544334,22.3079700141727,27.4582203798738,28.3225743799539,27.346123678252,22.1082149714329,26.6924364866605,11130,"ZW10 interacting kinetochore protein","protein_coding",null,null,"GO:0000070,GO:0000776,GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0007094,GO:0016604,GO:0030425,GO:0051301,GO:0051649,GO:0180019","mitotic sister chromatid segregation|kinetochore|protein binding|nucleoplasm|cytoplasm|cytosol|mitotic spindle assembly checkpoint signaling|nuclear body|dendrite|cell division|establishment of localization in cell|Knl1/Spc105 complex",null,null,"R-HSA-141424,R-HSA-141444,R-HSA-162582,R-HSA-1640170,R-HSA-194315,R-HSA-195258,R-HSA-2467813,R-HSA-2500257,R-HSA-2555396,R-HSA-5663220,R-HSA-68877,R-HSA-68882,R-HSA-68886,R-HSA-69278,R-HSA-69618,R-HSA-69620,R-HSA-9648025,R-HSA-9716542","Amplification of signal from the kinetochores|Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal|Signal Transduction|Cell Cycle|Signaling by Rho GTPases|RHO GTPase Effectors|Separation of Sister Chromatids|Resolution of Sister Chromatid Cohesion|Mitotic Metaphase and Anaphase|RHO GTPases Activate Formins|Mitotic Prometaphase|Mitotic Anaphase|M Phase|Cell Cycle, Mitotic|Mitotic Spindle Checkpoint|Cell Cycle Checkpoints|EML4 and NUDC in mitotic spindle formation|Signaling by Rho GTPases, Miro GTPases and RHOBTB3"]
["ZXDA",0.423452178083954,0.489446007907529,0.548521198403527,0.37527108528072,0.623288323648001,0.397643174696079,0.380074131846001,0.467797390173666,0.555333612643244,0.402676207370593,0.423436868034541,0.38827875116909,0.672864597562337,0.546796830565879,0.393808156858128,0.543799718024402,0.334975129444424,0.347169329872691,0.371547658825161,0.443281660166352,0.435090400005478,0.346461637513901,0.465665391428604,0.371807393576236,0.462333772344175,0.208817532858412,0.368271513629152,0.317467400918705,7789,"zinc finger X-linked duplicated A","protein_coding",null,null,"GO:0003712,GO:0003713,GO:0005515,GO:0005634,GO:0006357,GO:0045893,GO:0046872,GO:0070742","transcription coregulator activity|transcription coactivator activity|protein binding|nucleus|regulation of transcription by RNA polymerase II|positive regulation of DNA-templated transcription|metal ion binding|C2H2 zinc finger domain binding"]
["ZXDB",1.39539215503453,1.58050553159766,1.26375278887432,1.18221050329169,1.82123669180637,1.33349530406238,1.43069701369858,1.32963685211457,1.33910016010516,0.892795058488325,1.00160318190239,1.20049140598719,1.4254759446304,1.17520811398373,1.490299441697,1.49134610798241,0.933894880942363,1.11318077980313,1.36712140203529,1.28019945598257,1.30773555429265,1.08265673677966,1.2704698379576,1.09831542175778,1.09989555252464,0.960438423948196,1.10695591359556,1.07542253735712,158586,"zinc finger X-linked duplicated B","protein_coding",null,null,"GO:0003674,GO:0003712,GO:0005515,GO:0005634,GO:0006357,GO:0008150,GO:0046872","molecular_function|transcription coregulator activity|protein binding|nucleus|regulation of transcription by RNA polymerase II|biological_process|metal ion binding"]
["ZXDC",2.80559387607413,3.04745847485603,3.00795377038402,2.33362504958598,2.50458777090713,2.87040819640765,2.76301562503724,2.45396376459715,3.15302795714121,3.25675373578728,3.35105639884111,3.05788225769132,3.05101592698444,2.75321777086568,3.24135065034709,2.9064374264343,2.75152324265522,2.93242498707858,2.67702176870977,2.90192784548793,2.67258371223529,2.64212760337781,2.56029867572054,2.59294119016295,2.85879566295062,2.67404665049094,2.5180060506523,2.68642698842364,79364,"ZXD family zinc finger C","protein_coding",null,null,"GO:0003712,GO:0003713,GO:0005515,GO:0005575,GO:0005634,GO:0006357,GO:0030275,GO:0045893,GO:0046872,GO:0070742","transcription coregulator activity|transcription coactivator activity|protein binding|cellular_component|nucleus|regulation of transcription by RNA polymerase II|LRR domain binding|positive regulation of DNA-templated transcription|metal ion binding|C2H2 zinc finger domain binding",{"$nulls":4},"zf-C2H2"]
["ZYG11A",0.0971045217407893,0.0969806365744818,0.0592573804101132,0.0558773327506832,0.0806534834197663,0.0729488755534449,0.0317091746534553,0.0904593717184291,0.0293021957064317,0.0233810251661068,0.0228302972046292,0.0390780867681186,0.0554073235057144,0.00925772731865862,0.0180613324046941,9.20698369853995E-3,0.0793560982642212,0.0628931757899771,0.0673095524579155,0.0840399907043314,0.0412435212842804,0.0923014268868352,0.0479317701543762,0.0806381902702572,0.101085261526334,0.0692000711287269,0.0516814442262935,0.0912894857977775,440590,"zyg-11 family member A%2C cell cycle regulator","protein_coding",null,null,"GO:0031462","Cul2-RING ubiquitin ligase complex"]
["ZYG11B",6.82189105736449,6.1334139098872,5.28229937237883,4.1654493257844,6.98667075002013,5.69533093256492,4.9796691423345,4.60303036827605,6.45671893128319,3.72945891667613,4.32594348212639,4.77168964050717,8.01676798595215,4.48455110882038,7.0482379896614,6.55443150131701,4.70986819506428,4.49959387152645,4.86080635063738,6.23519520545334,5.2491987313087,5.00538469079732,7.14199780003415,6.3252133195403,4.9598128801609,4.12997499465858,5.28742201160466,4.17174247742763,79699,"zyg-11 family member B%2C cell cycle regulator","protein_coding",null,null,"GO:0005515,GO:0005737,GO:0006515,GO:0031462,GO:0032436","protein binding|cytoplasm|protein quality control for misfolded or incompletely synthesized proteins|Cul2-RING ubiquitin ligase complex|positive regulation of proteasomal ubiquitin-dependent protein catabolic process","WP4860,WP4352","Hijack of ubiquitination by SARS-CoV-2|Ciliary landscape"]
["ZYX",180.212219896295,247.042323294693,229.24378436603,261.879201932381,193.711286118494,258.915564618782,207.746345895666,231.527612118509,148.568830878383,235.245384862503,222.001219791101,169.282097469862,126.070030608787,161.682767136432,134.268366635672,138.622065642963,160.269852231027,189.558676861315,150.766984770391,168.03709804616,187.679659677303,192.815592798952,118.952471915044,141.961026002994,166.311656465326,205.273898319984,118.740762492603,203.486394477564,7791,"zyxin","protein_coding","hsa04510","Focal adhesion","GO:0001725,GO:0003723,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0005912,GO:0005925,GO:0007160,GO:0007179,GO:0007229,GO:0007267,GO:0015629,GO:0043149,GO:0045335,GO:0046872,GO:0071346","stress fiber|RNA binding|protein binding|nucleus|cytoplasm|cytosol|plasma membrane|adherens junction|focal adhesion|cell-matrix adhesion|transforming growth factor beta receptor signaling pathway|integrin-mediated signaling pathway|cell-cell signaling|actin cytoskeleton|stress fiber assembly|phagocytic vesicle|metal ion binding|cellular response to type II interferon","WP306,WP185","Focal adhesion|Integrin-mediated cell adhesion"]
["ZZEF1",5.01637530620711,5.23723543327986,4.62251394656083,4.05716365766563,5.05934131510794,4.98316359613312,4.2872362072229,4.08899070675575,4.68899979526677,5.46421288370937,4.17174035119707,4.32503700927249,4.45811536573999,4.49620302247741,4.41029244304782,4.86138651848536,3.58087382683383,4.15103424342179,3.21686953804581,4.26375103825123,3.75315050073563,3.58624479000272,3.24712710764906,3.48514445877263,4.16610556513723,3.37424686168518,2.98393290648702,3.17177145009294,23140,"zinc finger ZZ-type and EF-hand domain containing 1","protein_coding",null,null,"GO:0005509,GO:0005515,GO:0006325,GO:0008270,GO:0035064,GO:0070577,GO:0140566","calcium ion binding|protein binding|chromatin organization|zinc ion binding|methylated histone binding|lysine-acetylated histone binding|histone reader activity"]
["ZZZ3",9.45143063254146,8.56146277022606,7.88553516233048,6.58668842655837,9.18272540617079,7.84673833922312,7.59102878668574,7.27168636760297,8.35066750111615,5.51798444695464,5.42528672472244,7.00752994995384,9.12529461587382,6.93929836838987,8.30387683437762,8.71540633497818,8.57425491612726,6.58464539855497,7.91264502379646,8.62785107971465,8.03309538627201,7.03507385605872,10.8638135521686,9.53653613875691,7.95927542665605,7.16595889800567,8.82867358481455,6.72420707072104,26009,"zinc finger ZZ-type containing 3","protein_coding",null,null,"GO:0003677,GO:0005515,GO:0005654,GO:0005730,GO:0006325,GO:0006355,GO:0006357,GO:0008270,GO:0035064,GO:0045995,GO:0051302,GO:0051726,GO:0070577,GO:0072686,GO:0090043,GO:0140672","DNA binding|protein binding|nucleoplasm|nucleolus|chromatin organization|regulation of DNA-templated transcription|regulation of transcription by RNA polymerase II|zinc ion binding|methylated histone binding|regulation of embryonic development|regulation of cell division|regulation of cell cycle|lysine-acetylated histone binding|mitotic spindle|regulation of tubulin deacetylation|ATAC complex",null,null,"R-HSA-212165,R-HSA-3214847,R-HSA-3247509,R-HSA-4839726,R-HSA-74160,R-HSA-9772755","Epigenetic regulation of gene expression|HATs acetylate histones|Chromatin modifying enzymes|Chromatin organization|Gene expression (Transcription)|Formation of WDR5-containing histone-modifying complexes","MYB"]