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["SI Table S3. Gene Ontology (GO) enrichment analysis of the age and AD onset associated probes."]
[]
["Methylome Cortex"]
["GO Type","GO Name(GOID)","Number Changed","Number Measured","Number in GO","Z Score","PermuteP","gene symbols"]
["biological_process","L-amino acid import(GO:0043092)",3,7,9,5.88120358946,0.00102,"CLN8|SLC1A2|SLC6A1"]
["biological_process","endocrine process(GO:0050886)",4,16,21,4.88196176277,0.00128,"ACE|AVPR1B|ECE1|EDN1"]
["biological_process","protein oligomerization(GO:0051259)",13,162,239,3.41902971983,0.0022,"ALDOC|CRTC1|DPYSL3|GOPC|HR|IRS1|NACC2|PRKAR2A|SH3GLB1|SKIL|SLC6A1|SPAG9|TP53"]
["biological_process","regulation of neurogenesis(GO:0050767)",16,230,342,3.16789967315,0.00264,"ACE|C4orf31|DPYSL3|DTX1|MT3|P2RY2|PBX1|POU4F1|PTPRO|RYK|SKIL|SOX11|SPAG9|SPEN|TP53|ZEB1"]
["biological_process","regulation of protein homodimerization activity(GO:0043496)",3,10,14,4.74654451895,0.00306,"NRG1|SPAG9|TIRAP"]
["biological_process","response to purine-containing compound(GO:0014074)",3,10,16,4.74654451895,0.00346,"CCNE1|P2RY2|SLC6A1"]
["biological_process","prostaglandin metabolic process(GO:0006693)",4,20,23,4.20258528522,0.00346,"ACOX1|C1orf93|EDN1|PTGIS"]
["biological_process","microtubule anchoring(GO:0034453)",3,11,23,4.47033319927,0.00416,"BICD1|CASC5|DAG1"]
["biological_process","mesenchymal cell development(GO:0014031)",3,12,16,4.22704852615,0.00676,"EDN1|NRG1|SOX11"]
["biological_process","acidic amino acid transport(GO:0015800)",3,13,16,4.010320125,0.00744,"CLN8|SLC1A2|SLC6A1"]
[]
["Methylome Cerebellum"]
["GO Type","GO Name(GOID)","Number Changed","Number Measured","Number in GO","Z Score","PermuteP","gene symbols"]
["biological_process","positive regulation of hair follicle development(GO:0051798)",3,6,7,7.08649472759,0.0004,"MSX2|TGFB2|TRADD"]
["biological_process","regulation of cyclin-dependent protein kinase activity(GO:0000079)",6,55,82,3.71609966473,0.00382,"ANAPC2|CCNE1|CCNO|HEXIM2|MNAT1|SPDYA"]
["biological_process","ncRNA processing(GO:0034470)",9,116,202,3.32458054737,0.00454,"AARS|BXDC5|EXOSC5|INTS7|MOCS3|NOP14|NOP58|RPL14|TRUB1"]
["biological_process","prostanoid metabolic process(GO:0006692)",4,26,30,3.94979947933,0.00464,"ACOX1|C1orf93|LTA4H|PTGIS"]
["biological_process","negative regulation of cell projection organization(GO:0031345)",5,43,59,3.57290926326,0.00634,"DPYSL3|ITM2C|PTPRO|RTN4R|RUFY3"]
["biological_process","regulation of heart contraction(GO:0008016)",6,62,86,3.35147477384,0.00636,"AVPR1B|CYP2J2|DES|GNAO1|PDE5A|TGFB2"]
["biological_process","cellular macromolecule biosynthetic process(GO:0034645)",27,591,931,2.79835653849,0.00748,"EIF1|EIF3J|EIF3K|EIF5|FOXL1|LIN9|MED20|MLLT1|MNAT1|MRPL36|MTERF|NCBP2|NFATC3|NFATC4|NFE2L2|PBX4|PGM2|POLR3A|PPP1R10|PPP5C|PRIM2|RMI1|RPL14|RPL8|RPS29|TP53|TRNAU1AP"]
["biological_process","lamellipodium assembly(GO:0030032)",3,15,20,4.09327423528,0.00754,"JUB|LRRC16A|PTPRO"]
["biological_process","organic alcohol transport(GO:0015850)",3,16,23,3.9214659637,0.00894,"LY6E|PARK7|SLC44A1"]
["biological_process","RNA modification(GO:0009451)",4,31,54,3.46709385989,0.00932,"AARS|CDKAL1|MOCS3|TRUB1"]
[]
["Transcriptome Cortex"]
["GO Type","GO Name(GOID)","Number Changed","Number Measured","Number in GO","Z Score","PermuteP","gene symbols"]
["biological_process","positive regulation of immune system process(GO:0002684)",140,473,500,6.614227518,"<0.00001","ADAM8|ADK|ATF1|BAD|BCL10|C1QA|C1QB|C1QC|C1R|C2|C3|CCL19|CCL2|CCL5|CD37|CD4|CD46|CD74|CD79A|CD86|CDC42|CFB|CFD|CFH|CLU|CREB1|CXCL12|DMBT1|DUSP6|DUSP7|EBI3|EDN1|EDN3|ELANE|F7|FCER1G|FCN2|FCN3|FOS|FOXF1|FOXP1|FYB|FYN|GLI2|GLI3|HES1|HLA-DOA|HLA-DOB|HLA-DPB1|HLA-DQA1|HLA-DQA2|HLA-DQB1|HLA-DRB1|HLA-DRB3|HLA-DRB4|HLA-G|HLX|HMOX1|HPS1|HSPD1|IGF1|IKBKE|IL12A|IL15|IL1B|IL4R|IL6|IL6ST|IL7R|IL8|IRAK3|IRAK4|KCNN4|LAG3|LAT|LAT2|MAP3K7|MAP3K7IP1|MAP3K7IP2|MAPK10|MAPK14|MAPK7|MAPK9|MASP1|MAVS|MEF2A|MICB|MNDA|MOG|MYB|NCK2|NCKAP1L|NFKBIB|NKAP|NOS2|PAG1|PAK2|PDPK1|PIK3CA|PIK3R1|PIK3R3|PLCG1|PLD2|PLSCR1|PRKCZ|PSEN1|PTK2B|PTPN6|PTPRJ|RARA|RICTOR|RPS6KA2|RPS6KA3|SASH3|SELE|SH2D1B|SHH|SLC11A1|SPG21|STXBP2|SYK|TAC1|TAP2|TGFB2|THBS1|TIRAP|TLR10|TLR4|TLR5|TLR6|TLR7|TNFRSF4|TNFSF4|UBC|UBE2V1|VASP|VAV3|VCAM1|VEGFC|VSIG4"]
["biological_process","regulation of cell migration(GO:0030334)",94,318,321,5.380215177,"<0.00001","ABHD2|ABI3|ABR|ACVRL1|ADAM8|AGTR2|AIF1|ALOX15B|ANGPT2|APC|BMP4|CBLL1|CCL19|CCL2|CCL5|CD74|CLIC4|CNN2|CTSH|CX3CR1|CXCL12|DAB2IP|DACH1|DRD1|DRD5|EDN1|EDN3|EFNA1|EGFL7|EGFR|F3|F7|FOXC2|FOXF1|GNA13|GREM1|HDAC7|HDAC9|HIF1A|HMOX1|IGF1|IGF1R|IL6|IL6ST|IL8|INSR|KISS1R|LAMA1|LAMA3|LAMA4|LAMB1|LPAR1|MAGI2|MCC|MINK1|MYLK|NCKAP1L|NF2|NOG|NRP1|ONECUT2|PLAU|PLCG1|PLD2|PLXNA2|PTGER4|PTGS2|PTK2|PTK2B|PTP4A1|PTPRJ|PTPRU|RAP2B|RET|RTN4|SELE|SFRP2|SHH|SMAD7|SNAI2|SOX9|SPATA13|SPHK1|SST|STK10|SYNE2|TAC1|TGFB2|THBS1|TIE1|TIRAP|VCL|VEGFC|WDR44"]
["biological_process","reproductive behavior(GO:0019098)",11,18,18,4.750179386,"<0.00001","APLP2|APP|AVP|DRD1|DRD5|MAPK8IP2|NHLH2|NPAS3|OXTR|PPP1R1B|TH"]
["biological_process","regulation of cell adhesion(GO:0030155)",68,229,230,4.606935049,"<0.00001","ABI3BP|ACVRL1|ADAM22|ADAM8|ANGPT2|APC|ATXN3|C4orf31|CBLL1|CCL5|CD164|CDH1|COL8A1|DDR1|DSCAM|EDIL3|EFNA1|EGFLAM|EPHA3|EPHA8|ERBB3|FERMT3|FOXC2|FOXF1|FXYD5|FZD7|IL12A|IL1B|IL8|KIF26B|KLF4|KNG1|LAMA1|LAMA3|LAMA4|LAMB1|MAPK7|MINK1|NCKAP1L|NF2|NRG1|ONECUT2|PLAU|PLD2|PLEKHA2|PRSS2|PTK2|PTK2B|PTPRJ|RET|ROCK1|SDC4|SERPINI1|SFRP2|SIPA1|SMAD7|SNAI2|SOX9|SPP1|SYK|TGFB2|TGFBI|TGM2|THBS1|TNR|TSC1|UTRN|VAV3"]
["biological_process","unsaturated fatty acid biosynthetic process(GO:0006636)",21,49,52,4.518299403,"<0.00001","ABCC1|ALOX12B|ALOX15B|ALOX5AP|ALOXE3|CD74|DPEP2|EDN1|FADS3|GGT1|GGT5|GGTLC1|GGTLC3|LTC4S|PLA2G4A|PLA2G5|PTGIS|PTGS1|PTGS2|RNPEPL1|SYK"]
["biological_process","immune effector process(GO:0002252)",57,188,211,4.393077998,"<0.00001","ABCC9|ATP7A|BCL10|BNIP3L|C17orf60|C1QA|C1QB|C1QC|C1R|C2|C3|CD46|CD74|CD86|CFB|CFD|CFH|CLU|CTSH|CX3CR1|DICER1|ELANE|FCER1G|FCN2|FCN3|GPR183|HSPD1|IL28RA|IL6|ITGAX|LAT|LAT2|LIG4|LYST|MASP1|MLL5|MSH2|NLRP3|OAS1|PLSCR1|PSEN1|PTGER4|PTK2B|RAB27A|RELB|RSAD2|S100A13|SBNO2|SERPINB9|SH2D1B|SLC11A1|STXBP2|SYK|TLR4|TLR7|TNFSF4|VSIG4"]
["biological_process","cellular response to interferon-gamma(GO:0071346)",30,83,83,4.292877177,"<0.00001","AQP4|ASS1|CAMK2D|CCL2|CCL5|CD44|FCGR1A|FCGR1B|GBP1|HLA-C|HLA-DOA|HLA-DOB|HLA-DPB1|HLA-DQA1|HLA-DQA2|HLA-DQB1|HLA-DRB1|HLA-DRB3|HLA-DRB4|HLA-G|IRF2|IRF5|IRF6|NCAM1|NOS2|OAS1|PTPN2|PTPN6|SUMO1|VCAM1"]
["biological_process","cell communication(GO:0007154)",226,881,890,6.013774111,2e-05,"ABAT|ABCC9|ACCN1|ADNP|ADRA1D|AES|AIF1|ALB|AMH|AMPH|ANG|AP2A1|AQP1|AR|ASH1L|ATXN3|AVP|BCHE|BDNF|BRAF|C1QA|C7orf68|CACNA1A|CACNA1G|CACNB2|CACNB4|CAMK2D|CAMK4|CARTPT|CAV2|CCL15|CCL19|CCL23|CCL5|CCL8|CD33|CD86|CDC42|CDKN2B|CHRNA2|CHRNA5|CNIH2|COMT|CORT|CRB1|CREB1|CRH|CTF1|CTSL2|DLG3|DLGAP1|DRD1|DRD5|EDN1|EDN3|EFNA1|ENPEP|EPHA3|FGF12|FGF13|FGF14|FGF17|FGF18|FGF20|FOS|FOSL1|FREM1|FREM2|FREM3|FZD1|FZD2|FZD7|GABRA3|GABRA5|GABRB3|GABRG1|GABRG3|GAD1|GAL3ST4|GIPC1|GJA1|GJA4|GJA5|GJB1|GJB2|GJB6|GLS2|GLUL|GNAI1|GNG10|GNG12|GNG8|GREM1|GRIA3|GRIK1|GRIK4|GRIN2A|GRM7|GUCA1B|HCN2|HCN4|HCRT|HES1|HMOX1|HTR2C|HTR3A|HTR3B|IL15|IL1B|INHA|ITGB4|KCNA1|KCNA4|KCNAB1|KCNAB2|KCNC1|KCNC2|KCND3|KCNH2|KCNH5|KCNH7|KCNIP2|KCNJ11|KCNJ12|KCNJ14|KCNK10|KCNK13|KCNK4|KCNK6|KCNK7|KCNMB2|KCNN2|KCNN4|KCNQ5|KCNS3|KIF16B|KLF10|LTB|LTC4S|MAX|MBP|MINK1|MLL5|MMP3|MYCBPAP|MYLK2|NAMPT|NBR1|NCALD|NCF4|NODAL|NOXO1|NPTX1|NR4A2|NRG1|NRP1|NRXN1|NSF|NTN4|NTSR2|NUDT1|OSR1|PARK2|PCDH8|PCDHB10|PCDHB16|PCDHB3|PDPK1|PLD2|PLP1|PMAIP1|PMP22|PNOC|POMC|PRKACB|PTHLH|PTK2B|PTK7|RAB3A|RAPSN|RARA|RASGRF1|RASGRF2|RET|RIMS1|RPS6KA2|RPS6KA3|RPS6KA6|S100A9|SCN1B|SEMA3B|SFRP2|SHH|SIGLEC6|SLC1A6|SLC8A3|SNX12|SNX14|SNX15|SNX22|SNX24|SNX32|SNX5|SNX7|SOX9|SST|SSTR1|STAB1|STC1|STC2|STX1B|SYN1|TAC1|TFAP2C|TGFB2|TH|TNC|TNFSF10|TNRC6A|TRHDE|TRIP10|TXN2|UNC119|UNC13C|VAMP1|WNT2"]
["biological_process","negative regulation of locomotion(GO:0040013)",37,112,112,4.132966841,2e-05,"ABHD2|ABR|ACVRL1|AGTR2|ALOX15B|ANGPT2|CCL2|CLIC4|CNN2|CX3CR1|DAB2IP|DACH1|DRD1|DRD5|EGFL7|ELANE|GREM1|HMOX1|KISS1R|MAGI2|MCC|NF2|NOG|NRP1|PTGER4|PTPRJ|PTPRU|RAP2B|ROBO1|ROBO2|SEMA3F|SFRP2|SHH|SMAD7|THBS1|TIE1|VCL"]
["biological_process","positive regulation of neurological system process(GO:0031646)",18,44,44,3.944624358,2e-05,"C11orf9|CARTPT|CCL2|DICER1|DRD1|GFAP|GRIK1|HCRT|IL6|KISS1R|NMU|NPTN|NRXN1|OXTR|PRKCZ|PTGS2|TAC1|TNR"]
[]
["Transcriptome Cerebellum"]
["GO Type","GO Name(GOID)","Number Changed","Number Measured","Number in GO","Z Score","PermuteP","gene symbols"]
["biological_process","positive regulation of response to stimulus(GO:0048584)",235,893,926,6.62427922304,"<0.00001","ACVR1B|ACVR2B|ACVRL1|ADA|ADAM10|ADAM8|ADRA2B|ADRB2|AGER|AGPAT2|AKT2|ALB|APOL3|AR|ATF1|ATR|AXIN1|BCL10|BMP6|BMP7|BMPR1A|BRAF|BRCA1|C18orf32|C1QA|C1QB|C1QC|C1R|C2|C3|CAMK1D|CASP1|CASP8|CAV1|CAV2|CCL19|CCL2|CCL5|CD40|CD44|CD46|CD74|CD86|CDH13|CDKN1C|CDKN2B|CFH|CITED1|CLU|CRTAM|CSNK2A1|CXCL12|CYR61|DISC1|DRD3|DUSP22|DUSP6|DVL1|ECM1|EDN3|EDNRA|EEF1D|EGFR|EIF2AK3|ERBB2|ERCC8|EVC|EYA3|F3|FBXW7|FCER1A|FCER1G|FGFR1|FGFR4|FGR|FOS|FOXD4|FYB|FYN|GAS1|GAS6|GHR|GIMAP5|GIPC1|GJA1|GPR177|GPR44|HCLS1|HES1|HHEX|HIF1A|HLA-DOA|HLA-DOB|HLA-DQA1|HLA-DRA|HLA-DRB1|HLA-DRB4|HOMER1|HPSE|HSPD1|IGF1R|IKBKB|IKBKE|IL11|IL15|IL33|IL6ST|IL8|ILK|INPP5D|INSR|IRAK3|IRF7|ITGA5|ITGA8|ITSN1|JUB|JUP|KCNN4|KIAA1161|KIAA1303|KIF7|KITLG|KLK6|LAG3|LAT2|LCP2|LGALS9|LPAR2|LRRK2|LTA|LTBR|MAP2K6|MAP3K10|MAP3K7IP2|MAPK10|MAPK11|MAPK14|MAPK7|MAPK8IP2|MAPK9|MARCO|MASP1|MEF2A|MICB|MINK1|MOG|MPP7|MSX2|MYLK|NCAM1|NCOA3|NEDD4|NFKBIB|NOTCH2|NPTN|NTRK1|NTRK2|OPRM1|P2RX2|P2RX5|PAK2|PARK2|PDE2A|PDPK1|PIK3CA|PIK3R1|PLA2G7|PLA2R1|PLCG1|PLEKHG5|POLR3D|PPM1A|PRKCB|PRKCZ|PRKD2|PSEN1|PTGER4|PTGS2|PTK2|PTPN6|PTPRJ|PVRL2|RASGRF1|REL|RICTOR|RNF146|RPS6KA2|RPS6KA3|RRAGB|S100A13|S100A4|S100B|SASH3|SFRP4|SHH|SLC11A1|SLIT2|SOX11|SOX9|SPG21|SULF1|SULF2|SYK|TAC1|TAF9|TAOK2|TAP2|TCF7L2|TFG|THBS1|TLR4|TLR5|TLR6|TLR7|TLR9|TMEM173|TNFRSF10B|TNFSF10|TNFSF13B|TPD52L1|TRIM13|UBC|UBE2V1|VAPA|VASP|VAV3|VEGFC|VSIG4|VTN|WNT11|WNT2|WNT5A|ZDHHC13|ZNF423"]
["biological_process","positive regulation of immune system process(GO:0002684)",134,473,500,5.91562178386,"<0.00001","ADA|ADAM10|ADAM8|ADK|ATF1|BAD|BCL10|BDKRB1|C1QA|C1QB|C1QC|C1R|C2|C3|CAMK1D|CASP8|CAV1|CCL19|CCL2|CCL5|CD276|CD40|CD46|CD74|CD86|CDKN1A|CFH|CLU|CRTAM|CXCL12|DUSP6|EDN3|EDNRA|FCER1A|FCER1G|FES|FGR|FOS|FOXF1|FYB|FYN|GIMAP5|GLI2|GLI3|HES1|HLA-DOA|HLA-DOB|HLA-DQA1|HLA-DRA|HLA-DRB1|HLA-DRB4|HLA-G|HLX|HPS1|HSPD1|ICOS|IKBKB|IKBKE|IL15|IL33|IL4R|IL6ST|IL8|INPP5D|IRAK3|IRF7|KCNN4|LAG3|LAT2|LCP2|LTA|MAP2K6|MAP3K7IP2|MAP3K8|MAPK10|MAPK11|MAPK14|MAPK7|MAPK9|MARCO|MASP1|MEF2A|MIA3|MICB|MOG|NCK2|NFKBIB|NKAP|NOS2|PAK2|PDPK1|PIK3CA|PIK3R1|PLA2G7|PLCG1|POLR3D|PRDM1|PRKCB|PRKCZ|PRKD2|PSEN1|PTPN6|PTPRJ|PVRL2|RARA|RICTOR|RPS6KA2|RPS6KA3|SASH3|SHH|SLC11A1|SPG21|STAT6|STXBP2|SYK|TAC1|TAP2|THBS1|TLR4|TLR5|TLR6|TLR7|TLR9|TMEM173|TNFSF13B|UBC|UBE2V1|UNC13D|VASP|VAV3|VCAM1|VEGFC|VSIG4|WNT5A"]
["biological_process","regulation of locomotion(GO:0040012)",104,365,368,5.26188823016,"<0.00001","ABL1|ABL2|ACVRL1|ADA|ADAM10|ADAM8|AGER|AGTR2|AIF1|AKT2|ALOX15B|ANGPT2|APC|BCR|BDKRB1|BRCA1|CAMK1D|CBLL1|CCL19|CCL2|CCL5|CD74|CDH13|CLIC4|CTSH|CX3CR1|CXCL12|CXCL16|CXCR4|CYR61|DRD3|EDN3|EDNRA|EGFR|ETS1|F3|FES|FGFR1OP|FGR|FOXF1|GNA13|GRB7|HDAC5|HDAC7|HDAC9|HIF1A|IGF1R|IGFBP3|IL33|IL6ST|IL8|ILK|INSR|JUB|KISS1|LAMA1|LAMA4|LAMB1|LRRK2|MAGI2|MCC|MIA3|MINK1|MYLK|NF2|NR2F2|NRP1|ONECUT2|P2RY2|PLA2G7|PLCG1|PLD1|PLXNA2|PRKD2|PRKX|PTGER4|PTGS2|PTK2|PTP4A1|PTPRJ|PTPRO|PTPRU|RET|ROBO1|ROBO2|ROCK1|RTN4|SEMA3F|SHH|SLIT2|SMAD7|SNAI2|SOX9|SPATA13|SRPX2|SULF1|TAC1|THBS1|TIE1|VEGFC|VTN|WDR44|WNT11|WNT5A"]
["biological_process","immune response-regulating signaling pathway(GO:0002764)",60,197,203,4.56772910911,"<0.00001","ADAM8|ATF1|BCL10|CASP8|CD40|CD86|CTSH|DUSP6|FCER1G|FGR|FOS|FYB|FYN|HLA-DOA|HLA-DOB|HLA-DQA1|HLA-DRA|HLA-DRB1|HLA-DRB4|HLA-G|HSPD1|IKBKB|IKBKE|IL20RB|INPP5D|IRAK3|IRF7|LAT2|LCP2|MAP2K6|MAP3K7IP2|MAPK10|MAPK11|MAPK14|MAPK7|MAPK9|MARCO|MEF2A|MICB|NFKBIB|PAK2|PDPK1|PIK3CA|PIK3R1|PLCG1|PRKCB|PRKD2|PSEN1|RPS6KA2|RPS6KA3|SPG21|SYK|TLR4|TLR5|TLR6|TLR7|UBC|UBE2V1|VASP|VAV3"]
["biological_process","regulation of developmental process(GO:0050793)",291,1192,1207,5.95262730129,2e-05,"ABCG1|ABL1|ABL2|ACVR1B|ACVR2B|ACVRL1|ADA|ADAM8|ADAMTS9|ADRA2B|ADRB2|AGTR2|ALOX15B|AMIGO1|ANAPC2|ANGPT2|ANGPTL4|APC|APOLD1|APP|AQP1|AR|ARHGAP15|ARHGEF1|ATF1|ATN1|AXIN1|BAD|BAI1|BARHL2|BCL11A|BCOR|BDNF|BMP2K|BMP6|BMP7|BMPR1A|BOC|BRWD1|C11orf9|C1QC|C2orf86|C3|CAMK1D|CASP6|CAV1|CBFA2T2|CCDC85B|CCL19|CCL2|CCL5|CCNB1|CD276|CD40|CD74|CD86|CDC42EP1|CDC42EP2|CDC42EP5|CDC42SE2|CDK5RAP1|CDK5RAP2|CDKN2B|CDON|CELSR1|CITED1|CLU|COL4A2|CTSH|CX3CR1|CXCR4|CXorf15|CYR61|DICER1|DISC1|DNMT3B|DRD3|DUSP10|DUSP6|DVL1|ECM1|EDN3|EDNRA|EFEMP1|EGR1|EIF2AK3|EPHA3|EPHB2|ERBB2|ERMN|ETS1|F3|FAM40B|FBN2|FBXW7|FES|FGD2|FGD3|FGD6|FGFR1|FGR|FMNL3|FOXD4|FOXF1|FXN|GAS2|GDF10|GFAP|GHR|GIMAP5|GLI2|GLI3|GNA13|GNAS|HAND2|HDAC5|HDAC7|HDAC9|HES1|HEYL|HHEX|HIF1A|HLA-DOA|HLA-G|HLX|HMGB1|HMGB2|HOPX|HPN|HPS4|HPSE|IFT88|IGFBP3|IKZF3|IL15|IL1RN|IL4R|IL6ST|ILK|INHA|INPP5D|INSIG1|INSR|IRAK3|ISLR2|JUP|KIAA1109|KITLG|KLF10|KLF4|KLK6|KNDC1|L3MBTL|LAMA1|LAMA4|LBX1|LIG4|LRP5|LRRK2|LST1|LTBP4|LUC7L|LZTS1|MAFB|MAFF|MAG|MAP1B|MAP2K6|MAPK11|MAPK14|MAPK7|MAPK9|MARK2|MEF2A|MGP|MKL2|MSTN|MSX2|MYC|MYH14|NCOA3|NEDD4|NFKBID|NKAP|NME1|NOS3|NOTCH2|NPPC|NPTN|NRG1|NRP1|NTN4|NTRK1|NTRK2|NUMBL|OPRM1|OTX2|OXTR|P2RY2|PALM|PAX2|PAX6|PDLIM5|PIAS2|PIWIL2|PLA2G10|PLCG1|PMP22|PPARA|PRDM1|PRDX2|PRKCB|PRKCZ|PRKD2|PRKX|PRMT1|PSEN1|PTGS2|PTHLH|PTK2|PTK7|PTPRO|RARA|RBM24|RBM4|RCAN1|RET|RFX3|RHOJ|ROBO1|ROBO2|ROCK1|RPS6KA3|RPS6KA6|RTN4|S100A13|SASH3|SCIN|SEMA3F|SEPT7|SFRP4|SGK493|SHH|SIK1|SLC26A5|SLIT2|SMAD1|SMAD7|SMAD9|SMAP1|SMOC1|SNAI2|SOD2|SOX11|SOX3|SOX9|SPI1|SRPX2|STAB1|STAT6|SUFU|SULF1|SYK|SYNJ1|TAOK2|TCF7L1|TET1|TGIF1|TGIF2|THBS1|TIE1|TLR4|TNFRSF11B|TNR|TRPS1|TRPV1|TRPV2|TSPO|USP2|VEGFC|WIF1|WNT11|WNT2|WNT5A|WTIP|XYLT1|ZBTB16|ZBTB7A|ZC3H8|ZFHX3|ZMYM3"]
["biological_process","regulation of localization(GO:0032879)",274,1131,1139,5.61851463112,4e-05,"ABCG1|ABCG5|ABL1|ABL2|ACSL5|ACVRL1|ADA|ADAM10|ADAM8|ADRA2B|ADRB2|AGER|AGTR2|AIF1|AKT2|ALOX15B|AMPH|ANG|ANGPT2|ANXA2|APC|APLN|APOC1|AQP1|AR|ARFIP1|AVP|AXIN1|BAD|BARD1|BCL3|BCR|BDKRB1|BEST3|BMP7|BMPR1A|BRCA1|BTN2A2|C13orf34|C2orf86|C3|C7orf68|CACNA1C|CACNA1D|CACNB4|CACNG6|CADPS|CAMK1D|CAV1|CBLL1|CCL19|CCL2|CCL5|CCNB1|CD40|CD74|CDH13|CDKN1A|CEP120|CHRNA4|CLEC9A|CLIC4|CPLX3|CPLX4|CRHBP|CRTAM|CTSH|CX3CR1|CXCL12|CXCL16|CYR61|DPH3|DRD3|EDN3|EDNRA|EGFR|EPHA5|ETS1|F3|FBXW7|FCER1A|FCER1G|FES|FGFR1OP|FGR|FITM1|FOXF1|FXYD7|G3BP2|GAS1|GCC2|GCK|GFAP|GIMAP5|GJA1|GLI3|GNA13|GNAS|GRB7|GRIK1|GRM7|HCRT|HDAC5|HDAC7|HDAC9|HIF1A|HK2|HMGB1|HMGN3|IGF1R|IGFBP3|IL11|IL33|IL4R|IL6ST|IL8|ILK|INHA|INHBB|INPP5K|INSR|JUB|JUP|KCNA5|KCNG2|KCNJ11|KCNN4|KCNS3|KISS1|LAMA1|LAMA4|LAMB1|LRP5|MAGI2|MAP1B|MAPK7|MCC|MDFIC|MIA3|MINK1|MLC1|MTMR2|MXI1|MYLK|MYLK2|NEDD4|NF2|NFKBIB|NLRP2|NLRP3|NNAT|NOS2|NOS3|NR2F2|NR3C1|NRG1|NRP1|NSF|NUDT4|NUP98|NUPL1|ONECUT2|OPRM1|OXTR|P2RX2|P2RX5|P2RY12|P2RY2|PANX1|PARK2|PCSK9|PDE2A|PDPK1|PDZK1|PEX5L|PICALM|PIK3C3|PIK3R1|PKIA|PKIG|PLA2G10|PLA2G7|PLA2R1|PLCG1|PLD1|PLXNA2|PPARA|PPP3CA|PRAM1|PRKACB|PRKAR1A|PRKCB|PRKCZ|PRKD2|PRKX|PRSS8|PSMD10|PTGER4|PTGS1|PTGS2|PTK2|PTP4A1|PTPRJ|PTPRO|PTPRU|PYCARD|PYDC1|RAB14|RAB27A|RAB3A|RAB3B|RAB3C|RAE1|RANBP2|RAPGEF3|RBM4|RCVRN|RET|RFX3|RHBDF2|ROCK1|RTN4|SCIN|SCN3B|SEMA3F|SEPT2|SEPT5|SFRP4|SGK493|SHH|SIK1|SLC11A1|SLC30A4|SLIT2|SMAD7|SNAI2|SOX11|SOX9|SPATA13|SREBF2|SRPX2|STX1B|STXBP2|SUFU|SULF1|SUMO1|SYK|SYNJ1|SYT7|SYTL4|TAC1|TACC3|TCF7L2|THBS1|TIE1|TLR4|TLR7|TLR9|TMEM173|TNNC1|TRPV1|TRPV2|TSPO|UHMK1|UNC13D|USP6|VEGFC|VTN|WDR44|WIPF1|WNK3|WNT11|WNT5A|WWP2"]
["biological_process","regulation of myeloid leukocyte mediated immunity(GO:0002886)",11,20,21,4.30514324777,4e-05,"BCR|C3|FCER1A|FCER1G|FES|FGR|FOXF1|PRAM1|STXBP2|SYK|UNC13D"]
["biological_process","positive regulation of signaling(GO:0023056)",163,632,638,5.178928409,0.0001,"ACVR1B|ACVR2B|ACVRL1|ADA|ADAM8|ADRA2B|ADRB2|AGPAT2|AKT2|APOL3|AR|ATR|AXIN1|BCL10|BMP6|BMP7|BMPR1A|BRAF|C18orf32|CASP1|CASP8|CAV1|CAV2|CCL19|CCL2|CCL5|CD40|CD44|CD74|CDH13|CDKN1C|CDKN2B|CITED1|CSNK2A1|CYR61|DISC1|DRD3|DUSP22|DVL1|ECM1|EDNRA|EEF1D|EGFR|EIF2AK3|ERBB2|EVC|F3|FBXW7|FCER1A|FGFR1|FGFR4|FGR|FOXD4|GAS1|GAS6|GFAP|GHR|GIPC1|GJA1|GPR177|GPR44|GRIK1|HCLS1|HCRT|HES1|HHEX|HIF1A|HOMER1|HPSE|IGF1R|IKBKB|IKBKE|IL11|IL15|IL6ST|ILK|INSR|ITGA5|ITGA8|ITSN1|JUB|JUP|KCNN4|KIAA1161|KIAA1303|KIF7|KITLG|KLK6|LGALS9|LPAR2|LRRK2|LTBR|MAP3K10|MAP3K7IP2|MAPK8IP2|MINK1|MOG|MPP7|MSX2|NCAM1|NCOA3|NEDD4|NOTCH2|NPTN|NSF|NTRK1|NTRK2|OPRM1|OXTR|P2RX2|P2RX5|PARK2|PLA2R1|PLEKHG5|PPM1A|PRKCB|PRKCZ|PRKD2|PSEN1|PTGS2|PTK2|PTPN6|PTPRJ|RAMP3|RASGRF1|REL|RICTOR|RNF146|RRAGB|S100A13|S100A4|S100B|SFRP4|SHH|SLC24A2|SOX11|SOX9|SULF1|SULF2|SYK|TAC1|TAOK2|TCF7L2|TFG|THBS1|TLR4|TLR5|TLR6|TLR9|TNFRSF10B|TNFSF10|TNR|TPD52L1|TRIM13|UBC|UBE2V1|VAPA|VTN|WNT11|WNT2|WNT5A|ZDHHC13|ZNF423"]
["biological_process","neural crest cell development(GO:0014032)",9,15,15,4.23185368457,0.0001,"ALDH1A2|BMPR1A|EDNRA|HAND2|HES1|NRG1|SNAI2|SOX11|SOX9"]
["biological_process","locomotion(GO:0040011)",217,881,889,5.24148615028,0.00012,"ABL1|ABL2|ACVRL1|ADAM8|AMICA1|ANG|ANGPT2|ANK1|AP2A1|APC|ARHGEF11|ARTN|ASTN1|ATN1|ATP1B3|B3GNT2|BARHL2|BDKRB1|BDNF|BMP7|C1orf187|CACNA1C|CACNA1D|CACNA1G|CACNB4|CAV1|CCL19|CCL2|CCL3L3|CCL5|CCL8|CD58|CDC42BPA|CDH13|CELSR1|CHL1|CLN6|CLTC|CMTM3|CMTM7|CNTN1|COL1A2|COL4A2|COL4A5|COL5A2|COL6A3|CSNK2A1|CX3CR1|CXCL12|CXCL14|CXCL16|CXCR4|CYP1B1|CYR61|DBH|DEFB1|DISC1|DLG3|DNAH17|DNAH2|DNAH7|DOCK2|DST|DVL1|EDN3|EGFR|EGR2|EGR3|ELMO2|ENPEP|EPHA3|EPHA5|EPHB2|EPHB4|ERBB2|ETS1|F11R|FAM40B|FCER1G|FERMT1|FES|FGFR1|FGFR4|FMNL3|FOSL1|FOXD4|FPR1|FYN|GAS1|GAS6|GFRA1|GIPC1|GLI2|GLI3|GP6|GPR44|GRB7|HAND2|HES1|HIF1A|HMGB1|HMGB2|IL8|INPP5D|ITGA2|ITGA2B|ITGA4|ITGA5|ITGA6|ITGAX|ITGB4|JUB|JUP|KITLG|LAMA1|LAMB1|LHX6|LRRK2|LSP1|MAG|MAPK14|MARK2|MSX2|MYH11|MYH14|MYL9|MYO18A|NANOS1|NCAM1|NCK2|NEDD4|NFASC|NOS3|NR2F2|NR4A2|NR4A3|NRP1|NRXN3|NTN4|NTRK2|OLR1|OTX2|PAK2|PAK7|PIK3CA|PIK3R1|PIP5K1A|PLA2G10|PLCG1|PLD1|PLP2|PLTP|PLXNA2|PLXNC1|PPAP2B|PPIA|PPIL2|PPP1R9B|PRKD2|PRKX|PROK2|PSEN1|PSPN|PTK2|PTK7|PTPN6|PTPRJ|PTPRO|RAC2|RANBP9|RET|RFX3|ROBO1|ROBO2|ROCK1|ROPN1L|RPS6KA2|RPS6KA3|RPS6KA6|RTN4|S100A8|S100A9|SATB2|SCN3B|SCN8A|SEMA3E|SEMA3F|SEMA5A|SEMA6D|SHH|SIAH1|SLC3A2|SLC7A8|SLIT2|SORD|SPATA13|SPON2|SPTB|SPTBN1|SPTBN5|SRGAP2|SRPX2|ST8SIA2|SYK|TAOK2|THBS1|TNR|TNS1|TSPO|TYROBP|UNC5D|VASP|VAV2|VAV3|VEGFC|WNT5A|WWP2"]
[]
["Methylome - Overlap Between Cortex and Cerebellum"]
["GO Type","GO Name(GOID)","Number Changed","Number Measured","Number in GO","Z Score","PermuteP","gene symbols"]
["biological_process","protein oligomerization(GO:0051259)",8,162,239,4.8613855288,0.00032,"CRTC1|DPYSL3|NACC2|PRKAR2A|SH3GLB1|SLC6A1|SPAG9|TP53"]
["biological_process","prostaglandin metabolic process(GO:0006693)",3,20,23,6.09486663393,0.0011,"ACOX1|C1orf93|PTGIS"]
["biological_process","glycerolipid biosynthetic process(GO:0045017)",4,68,105,3.89747815731,0.00514,"CD81|CDIPT|ELOVL2|PNPLA3"]
["biological_process","acylglycerol metabolic process(GO:0006639)",3,54,82,3.23552575624,0.01886,"CDIPT|ELOVL2|PNPLA3"]
["biological_process","regulation of protein complex assembly(GO:0043254)",4,107,156,2.72094566343,0.02556,"ARPC1B|ARPC4|RNF4|SH3GLB1"]
["biological_process","regulation of protein serine/threonine kinase activity(GO:0071900)",6,234,327,2.27479139404,0.03548,"CCNE1|CD81|MAP4K5|SPAG9|SPDYA|UCHL1"]
["biological_process","cell projection assembly(GO:0030031)",3,70,119,2.6455134791,0.036,"MYH10|PTPRO|SH3GLB1"]
["biological_process","fatty acid biosynthetic process(GO:0006633)",3,72,105,2.58429746431,0.04002,"C1orf93|ELOVL2|PTGIS"]
[]
["Transcriptome - Overlap Between Cortex and Cerebellum"]
["GO Type","GO Name(GOID)","Number Changed","Number Measured","Number in GO","Z Score","PermuteP","gene symbols"]
["biological_process","positive regulation of immune system process(GO:0002684)",88,473,500,5.92710679549,0,"ADAM8|ADK|ATF1|BAD|BCL10|C1QA|C1QB|C1QC|C1R|C2|C3|CCL19|CCL2|CCL5|CD46|CD74|CFH|CLU|CXCL12|EDN3|FCER1G|FOS|FOXF1|FYB|FYN|GLI2|GLI3|HES1|HLA-DOA|HLA-DOB|HLA-DQA1|HLA-DRB1|HLA-G|HLX|HPS1|HSPD1|IKBKE|IL15|IL4R|IL6ST|IL8|IRAK3|KCNN4|LAG3|LAT2|MAP3K7IP2|MAPK10|MAPK14|MAPK7|MAPK9|MASP1|MEF2A|MICB|MOG|NCK2|NFKBIB|NKAP|PAK2|PDPK1|PIK3CA|PIK3R1|PLCG1|PSEN1|PTPN6|PTPRJ|RARA|RICTOR|RPS6KA3|SASH3|SHH|SLC11A1|SPG21|STXBP2|SYK|TAC1|TAP2|THBS1|TLR4|TLR5|TLR6|TLR7|UBC|UBE2V1|VASP|VAV3|VCAM1|VEGFC|VSIG4"]
["biological_process","immune response-regulating signaling pathway(GO:0002764)",42,197,203,5.04943526896,0,"ADAM8|ATF1|BCL10|CTSH|FCER1G|FOS|FYB|FYN|HLA-DOA|HLA-DOB|HLA-DQA1|HLA-DRB1|HLA-G|HSPD1|IKBKE|IRAK3|LAT2|MAP3K7IP2|MAPK10|MAPK14|MAPK7|MAPK9|MEF2A|MICB|NFKBIB|PAK2|PDPK1|PIK3CA|PIK3R1|PLCG1|PSEN1|RPS6KA3|SPG21|SYK|TLR4|TLR5|TLR6|TLR7|UBC|UBE2V1|VASP|VAV3"]
["biological_process","alkene biosynthetic process(GO:0043450)",11,30,32,4.71676696913,2e-05,"ABCC1|ALOX12B|ALOX15B|ALOX5AP|ALOXE3|GGTLC1|GGTLC3|LTC4S|PLA2G5|RNPEPL1|SYK"]
["biological_process","regulation of DNA replication(GO:0006275)",20,87,89,3.85591525059,2e-05,"ACVRL1|ATF1|CDK2|DSCC1|EGFR|ESCO1|FBXW7|GLI2|HCRT|IGF1R|INO80|INSR|KITLG|MRE11A|NF2|PCNA|S100A11|TERF1|TIPIN|TSPYL2"]
["biological_process","response to external stimulus(GO:0009605)",148,978,983,4.99237278712,4e-05,"ACSL5|ADAM8|AES|AIF1|ALB|AMICA1|ANGPT2|AP2A1|AQP1|ARSB|ATOH7|B3GNT2|BAD|BCHE|BCKDHB|BCL10|BDNF|C1orf187|CACNA1C|CACNA1G|CACNB4|CASP1|CCL19|CCL2|CCL3L3|CCL5|CCL8|CCNB1|CDH23|CDKN2B|CHL1|CLTC|CMTM3|CNTN1|COL1A2|COL4A2|COL4A5|COL6A3|CTSH|CX3CR1|CXCL12|CXCR4|DCN|DLG3|DVL1|EDN3|EGFR|EGR2|EPHA3|EPHB2|F3|FCER1G|FOS|FOSL1|FOXF1|FPR1|FYN|GAS1|GDAP1|GLI2|GLI3|GNAT1|GPR44|HAT1|HMGB1|HMGB2|HPN|IGF1R|IL15|IL6ST|IL8|INHA|INSR|ITGA2|ITGA5|KLF4|LAMA1|LAMB1|LTBR|LTC4S|MAP1B|MAPK14|MAX|MGP|MICB|MMP3|MYH11|MYH14|MYL9|NCAM1|NCK2|NR4A2|NR4A3|NRXN3|PAK2|PARK2|PEMT|PER1|PIP5K1A|PLA2G10|PLCG1|PLXNA2|PLXNC1|PTGER4|PTK2|PTK7|PTPRJ|RANBP9|RARA|RCAN1|RCVRN|RET|ROBO1|ROCK1|RPS6KA3|RPS6KA6|S100A8|S100A9|SCN3B|SCN8A|SEMA3E|SEMA3F|SEMA6D|SHH|SLC12A2|SLC30A4|SOX9|SPTBN5|ST8SIA2|STC1|STC2|SYK|SYNJ1|TIE1|TLR4|TLR5|TLR7|TNR|TNRC6A|TSPO|TXN2|UNC119|UNC5D|VASP|VCAM1|VEGFC|WDR45|WNT2"]
["biological_process","regulation of cell migration(GO:0030334)",56,318,321,4.25101258626,6e-05,"ACVRL1|ADAM8|AGTR2|AIF1|ALOX15B|ANGPT2|APC|CBLL1|CCL19|CCL2|CCL5|CD74|CLIC4|CTSH|CX3CR1|CXCL12|EDN3|EGFR|F3|FOXF1|GNA13|HDAC7|HDAC9|HIF1A|IGF1R|IL6ST|IL8|INSR|LAMA1|LAMA4|LAMB1|MAGI2|MCC|MINK1|MYLK|NF2|ONECUT2|PLCG1|PLXNA2|PTGER4|PTK2|PTP4A1|PTPRJ|PTPRU|RET|RTN4|SHH|SMAD7|SNAI2|SOX9|SPATA13|TAC1|THBS1|TIE1|VEGFC|WDR44"]
["biological_process","regulation of cell-substrate junction assembly(GO:0090109)",8,18,18,4.73381352757,0.0001,"ACVRL1|EPHA3|PTK2|PTPRJ|ROCK1|SDC4|THBS1|TSC1"]
["biological_process","determination of left/right symmetry(GO:0007368)",12,39,39,4.17155016874,0.00012,"ACVR2B|ARL6|BBS7|DYNC2LI1|FOXF1|IFT88|LEFTY1|PCSK6|RPGRIP1L|SHH|SUFU|TGIF1"]
["biological_process","spinal cord dorsal/ventral patterning(GO:0021513)",4,5,5,5.0987244777,0.0002,"GLI2|GLI3|SHH|SUFU"]
["biological_process","locomotion(GO:0040011)",132,881,889,4.57449852903,0.00022,"ACVRL1|ADAM8|AMICA1|ANGPT2|AP2A1|APC|ATN1|ATP1B3|B3GNT2|BDNF|C1orf187|CACNA1C|CACNA1G|CACNB4|CCL19|CCL2|CCL3L3|CCL5|CCL8|CD58|CDC42BPA|CHL1|CLTC|CMTM3|CNTN1|COL1A2|COL4A2|COL4A5|COL6A3|CX3CR1|CXCL12|CXCR4|DISC1|DLG3|DNAH17|DST|DVL1|EDN3|EGFR|EGR2|ENPEP|EPHA3|EPHB2|EPHB4|F11R|FCER1G|FERMT1|FGFR4|FMNL3|FOSL1|FPR1|FYN|GAS1|GAS6|GIPC1|GLI2|GLI3|GP6|GPR44|HES1|HIF1A|HMGB1|HMGB2|IL8|ITGA2|ITGA5|ITGA6|ITGAX|ITGB4|KITLG|LAMA1|LAMB1|MAG|MAPK14|MARK2|MYH11|MYH14|MYL9|NANOS1|NCAM1|NCK2|NR4A2|NR4A3|NRXN3|NTRK2|PAK2|PIK3CA|PIK3R1|PIP5K1A|PLA2G10|PLCG1|PLTP|PLXNA2|PLXNC1|PPAP2B|PPIA|PPIL2|PSEN1|PTK2|PTK7|PTPN6|PTPRJ|RANBP9|RET|RFX3|ROBO1|ROCK1|RPS6KA3|RPS6KA6|RTN4|S100A8|S100A9|SCN3B|SCN8A|SEMA3E|SEMA3F|SEMA6D|SHH|SORD|SPATA13|SPTBN5|ST8SIA2|SYK|TAOK2|THBS1|TNR|TNS1|TSPO|UNC5D|VASP|VAV3|VEGFC"]
[]
["AD Cortex"]
["GO Type","GO Name(GOID)","Number Changed","Number Measured","Number in GO","Z Score","PermuteP","gene symbols"]
["biological_process","positive regulation of transcription from RNA polymerase II promoter(GO:0045944)",10,93,434,4.065655006,0.00105,"FOXL2|HMGB2|LMX1B|NR5A2|PAX2|PAX9|SALL1|SIX3|SOX2|SOX6"]
["biological_process","sensory organ development(GO:0007423)",5,26,94,4.536124036,0.00135,"BCL2L11|LMX1B|PAX2|SIX3|SOX2"]
["biological_process","cell-cell signaling involved in cell fate commitment(GO:0045168)",3,8,24,5.386489643,0.00155,"SALL1|SIX3|SOX2"]
["biological_process","regulation of Wnt receptor signaling pathway(GO:0030111)",4,28,140,3.244028111,0.012,"SALL1|SENP2|SIX3|SOX2"]
["biological_process","regulation of caspase activity(GO:0043281)",3,16,131,3.442813117,0.01345,"FOXL2|MGMT|SOX2"]
["biological_process","developmental process involved in reproduction(GO:0003006)",6,66,326,2.640268378,0.01815,"BCL2L11|FOXL2|HMGB2|MTOR|SALL1|SOX2"]
["biological_process","embryo development(GO:0009790)",6,69,321,2.515864087,0.02595,"BCL2L11|LMX1B|NR5A2|POLR1B|SLC30A1|SOX6"]
["biological_process","lipid metabolic process(GO:0006629)",8,114,968,2.244642046,0.0307,"CDS1|CFTR|CHPT1|GRHL1|MCEE|NR5A2|PLCZ1|TIAM2"]
["biological_process","gland development(GO:0048732)",3,23,110,2.603473626,0.0381,"BCL2L11|SALL1|SOX2"]
["biological_process","kidney development(GO:0001822)",3,23,109,2.603473626,0.03995,"BCL2L11|PAX2|SALL1"]