{"text_format":"3","workbook":"xls","n_sheets":5,"sheets":["Table S1","Table S2","Table S3","Table S4","Table S5"],"read":"whole","date_system":"1900","formulas":"cached_only"}

{"sheet":"Table S1","index":0,"n_rows":40,"n_cols":21,"rows_kept":40,"merged":[[0,0,0,5],[0,7,0,8],[0,11,0,12],[0,17,0,20],[39,3,39,14]],"flags":["formulas_cached_only"]}
["Table S1: Patients included in RNA analyses",{"$nulls":6},"Samples used for",{"$nulls":3},"Samples used for",{"$nulls":3},"Samples used for",null,"Samples used for"]
["ID","Type","Stage, grade","Age group*",null,"Tumor cells / spheroids","Cultured Tumor cells","RNA-Seq","RT-pPCR",null,"TAM","RNA-Seq","RT-pPCR",null,"TAT","RNA-Seq",null,"  Fig 1B-E","Fig 2A, 2B, 5A, 5B","Fig 3A, 5C","Fig 3E"]
[22,"high-grade serous","G2, pT3c",7,null,"-",null,null,"x",null,"TAM22","x","x",{"$nulls":4},"  see legend","OC27L","OC27L","OC28_cu"]
[24,"high-grade mucinous","G2, pT1c",3,null,"-",null,null,"x",null,"TAM24","x","x",{"$nulls":5},"OC27s","OC27s","OC28"]
[25,"high-grade serous","G2, pT3c",7,null,"-",null,null,"x",null,"TAM25",null,"x",{"$nulls":5},"OC28","OC28sc"]
[27,"high-grade serous","G3, pT3c",7,null,"OC27s, OC27L",null,"x","x",null,"TAM27",null,"x",{"$nulls":5},"OC34s","OC34sc","OC65L_cu"]
[28,"high-grade serous","G3, pT3c",7,null,"OC28sc","OC28sc_cu","x","x",null,"TAM28",null,"x",{"$nulls":5},"OC65L","OC65L","OC65L"]
[29,"high-grade serous","G3, pT3c",4,null,"-",null,null,"x",null,"TAM29","x","x",{"$nulls":5},"OC66L","OC65s"]
["30","high-grade serous","G3, pT3c",5,{"$nulls":6},"TAM30","x",{"$nulls":6},"OC66s","OC66L","OC65s_cu"]
["31","high-grade serous","G3, pT3c",6,null,"-",null,null,"x",null,"TAM31","x",null,null,"TAT31","x",null,null,"OC70L","OC66s","OC65s"]
["34","borderline serous","-",2,null,"OC34sc",null,"x","x",null,"-",null,"x",{"$nulls":5},"OC70m","OC70L"]
[38,"high-grade serous","G2, pT3c",5,null,"-",null,null,"x",null,"TAM38","x","x",{"$nulls":5},"OC70sc","OC70m","OC66s_cu"]
[43,"high-grade mixed serous / mucinous","G3, pT3c",5,null,"-",null,null,"x",null,"TAM43","x","x",{"$nulls":5},"OC87L","OC70s","OC66_s"]
["44","high-grade serous","Peritoneal ca. G2",7,{"$nulls":14},"OC87m","OC70sc"]
[46,"high-grade serous","G3, pT3c",6,null,"-",null,null,"x",null,"TAM46",null,"x",{"$nulls":5},"OC92L","OC82m"]
[47,"high-grade serous","G2, pT3c",8,null,"-",null,null,"x",null,"TAM47",null,"x",{"$nulls":5},"OC105L","OC84s"]
[49,"high-grade serous","Peritoneal ca. G3",7,null,"-",null,null,"x",null,"TAM49",null,"x",{"$nulls":5},"OC108L","OC87L"]
["50","high-grade serous","G3, pT3c",6,{"$nulls":10},"TAT50","x",null,null,"OC108s","OC87m"]
["51","high-grade serous","G3, pT3c",4,{"$nulls":10},"TAT51","x",null,null,"OC112L"]
["52","high-grade serous","G2, pT3c",8,{"$nulls":6},"TAM52","x","x",{"$nulls":5},"OC114s","TAM22"]
["54","high-grade serous","G3, pT3c",7,{"$nulls":6},"TAM54",null,"x",{"$nulls":5},"OC116s","TAM24"]
[65,"high-grade serous","G3, pT3c",4,null,"OC65s, OC65L","OC65s_cu, OC65L_cu","x","x",null,"TAM65",null,"x",{"$nulls":5},"OC117s","TAM25"]
[66,"high-grade serous","G3, pT3c",7,null,"OC66s, OC66L","OC66s_cu, OC66L_cu","x","x",null,"TAM66","x","x",{"$nulls":6},"TAM27"]
["69","high-grade serous","G2, pT3c",6,{"$nulls":6},"TAM69","x","x",{"$nulls":5},"TAM22","TAM28"]
[70,"high-grade serous","G3, pT3c",7,null,"OC70sc, OC70m, OC70L",null,"x","x",null,"TAM70","x","x",{"$nulls":5},"TAM24","TAM29"]
[72,"high-grade serous","Peritoneal ca. G2",7,null,"-",null,null,"x",null,"TAM72","x","x",{"$nulls":5},"TAM29","TAM38"]
["82","high-grade serous","G3, pT3c",4,null,"OC82m",null,null,"x",null,"-",null,"x",{"$nulls":5},"TAM31","TAM43"]
[84,"high-grade serous","G2, pT3c",7,null,"OC84s",null,null,"x",null,"-",null,"x",{"$nulls":5},"TAM43","TAM46"]
[87,"high-grade serous","G3, pT3c",8,null,"OC87m, OC87L",null,"x","x",null,"-",null,"x",{"$nulls":5},"TAM70","TAM47"]
["92","high-grade serous","G3, pT3c",6,null,"OC92L",null,"x",null,null,"TAM92","x",{"$nulls":6},"TAM72","TAM49"]
["101","high-grade serous","G3, pT3c",7,{"$nulls":10},"TAT101","x",null,null,"TAM92","TAM65"]
["105","high-grade serous","G3, pT3c",6,null,"OC105L",null,"x",null,null,"TAM105","x",{"$nulls":6},"TAM105","TAM66"]
["106","high-grade serous","G3, pT3c",4,{"$nulls":10},"TAT106","x",null,null,"TAM108","TAM70"]
["108","high-grade serous","G3, pT3c",6,null,"OC108s, OC108L",null,"x",null,null,"TAM108","x",{"$nulls":6},"TAM112","TAM72"]
["112","high-grade serous","G3, pT3c",5,null,"OC112L",null,"x",null,null,"TAM112","x",{"$nulls":6},"TAM114"]
["114","high-grade serous","G3, pT3c",5,null,"OC114s",null,"x",null,null,"TAM114","x",{"$nulls":6},"TAM116"]
["116","high-grade serous","G3, pT3c",7,null,"OC116s",null,"x",null,null,"TAM116","x",{"$nulls":6},"TAM117"]
["117","high-grade serous","G3, pT3c",4,null,"OC117s",null,"x",null,null,"TAM117","x"]
[]
[{"$nulls":3},"*age groups (used to ensure anonymity): 2: 20-30 years; 3: 30-40 years; 4: 40-50 years; 5: 50-60 years; 6: 60-70 years; 7: 70-80 years"]

{"sheet":"Table S2","index":1,"n_rows":32,"n_cols":6,"rows_kept":32,"flags":["formulas_cached_only"]}
["Table S2: Characteristics of tumor cells and spheroids"]
["Sample","Aneuploid (%)*","Chemoresistant (%)","Adherent (%)","Ki67+ (%)","TAMs  (%)**"]
[]
["OC27s",0,40,50,18.3,"<3"]
["OC27L",0,30,20,20.7,"<3"]
[]
["OC28sc",56.1,97,50,3.9,"~10"]
[]
["OC34sc",0,64,90,0.2,"<3"]
[]
["OC38sc",0,100,"<5",3.2,"<3"]
[]
["OC65s",11.3,36,70,0,"~20"]
["OC65L",86.8,100,"<5",0.4,"<3"]
[]
["OC66s",22,24,90,5.5,"<3"]
["OC66L",79.9,90,10,9.8,"<3"]
[]
["OC70sc",0,50,50,"n.d.","<3"]
["OC70m",0,41,50,"n.d.","<3"]
["OC70L",0,18,50,"n.d.","<3"]
[]
["OC82m",68.2,"n.d.","n.d.",3.6,"~10"]
[]
["OC84s",45.7,47,"<5",7,"~15"]
[]
["OC87m",63.1,83,40,25.4,"<3"]
["OC87L",91.5,92,10,48.5,"<3"]
[]
[]
["*assessed by flow cytometry analysis of propidium iodide (DNA content)"]
["**estimated by microscopic inspection and flow cytometry (CD14+)"]

{"sheet":"Table S3","index":2,"n_rows":42,"n_cols":4,"rows_kept":42,"flags":["formulas_cached_only"]}
["Table S3: Patients included in cytokine expression analyses"]
["ID","Age","Type","Stage, grade "]
[15,69,"high-grade serous","G3, pT3c"]
[17,66,"high-grade serous","G2, pT3c"]
[18,65,"high-grade serous","G2, pT3c"]
[19,74,"high-grade serous","G2-3, pT3c"]
[20,48,"high-grade serous","G2, pT3c"]
[21,71,"high-grade serous","G2, pT3c"]
[23,72,"high-grade serous","G2, pT3c"]
[24,35,"high-grade mucinous","G2, pT1c"]
[25,76,"high-grade serous","G2, pT3c"]
[26,74,"high-grade serous","G2, pT3b"]
[27,72,"high-grade serous","G3, pT3c"]
[28,71,"high-grade serous","G3, pT3c"]
[29,46,"high-grade serous","G3, pT3c "]
[30,54,"high-grade serous","G3, pT3c"]
[31,60,"high-grade serous","G3, pT3c"]
[32,53,"high-grade serous","G1, pT3a"]
[36,56,"high-grade serous","G2-3, pT3c"]
[37,61,"high-grade serous","G2, pT3c"]
[38,53,"high-grade serous","G2, pT3c"]
[41,39,"high-grade serous","G3, pT3c"]
[42,44,"high-grade serous","G3, pT3c"]
[43,55,"high-grade mixed serous / mucinous","G3, pT3c"]
[44,72,"high-grade serous","Peritoneal ca. G2"]
[46,61,"high-grade serous","G3, pT3c"]
[47,85,"high-grade serous","G2, pT3c"]
[48,62,"high-grade serous","G2, pT2b"]
[49,75,"high-grade serous","Peritoneal ca. G3"]
[50,66,"high-grade serous","G3, pT3c"]
[51,49,"high-grade serous","G3, pT3c"]
[54,75,"high-grade serous","G3, pT3c"]
[55,66,"high-grade serous","G3, pT3c"]
[58,81,"high-grade serous","G3, pT3b"]
[61,44,"high-grade serous","G3, pT2a"]
[63,54,"high-grade serous","G3, pT3c"]
[65,44,"high-grade serous","G3, pT3c"]
[66,71,"high-grade serous","G3, pT3c"]
[67,87,"high-grade serous","Peritoneal Ca. G2"]
[68,62,"high-grade serous","G3, pT3c"]
[69,62,"high-grade serous","G2, pT3c"]
[72,78,"high-grade serous","Peritoneal ca. G2"]

{"sheet":"Table S4","index":3,"n_rows":15,"n_cols":4,"rows_kept":15,"flags":["formulas_cached_only"]}
["Table S4: Patient-specific expression of cytokine and growth factor genes by TAMs complementing the signaling networks in Fig. 4 and 6"]
["Gene","Description","Minimum TPM","Maximum TPM"]
["CCL13","chemokine (C-C motif) ligand 13",0.06,67.22]
["CCL24","chemokine (C-C motif) ligand 24",0,7.13]
["CXCL14","chemokine (C-X-C motif) ligand 14",0,4.51]
["CXCL5","chemokine (C-X-C motif) ligand 5",0.25,8.3]
["DLL1","delta-like 1 (Drosophila)",0.38,4.11]
["FGF11","fibroblast growth factor 11",0.21,3.68]
["FGF13","fibroblast growth factor 13",0,5.37]
["IL1A","interleukin 1, alpha",0,22.36]
["IL7","interleukin 7    ",0.438257,4.450088]
["IL32","interleukin 32",0,6.84]
["LEP","leptin",0.06,78.54]
["LTB","lymphotoxin beta (TNF superfamily, member 3)",0,3.76]
["NRG1","neuregulin 1",0.1,5.71]

{"sheet":"Table S5","index":4,"n_rows":92,"n_cols":2,"rows_kept":92,"merged":[[0,0,0,1]],"flags":["formulas_cached_only"]}
["Table S5: Primers used for RT-qPCR-analyses"]
["name","sequence"]
[]
["ALOX5AP_fw","5' CTCTCACTTCCCCTTCCTGTA"]
["ALOX5AP_rv","5' TCTACACAGTTCTGGTTGGC"]
[]
["ANGPTL4_fw","5' TTTTGGTGAACTGCAAGATGA"]
["ANGPTL4_rv","5' GAAGTCCACTGAGCCATCGT"]
[]
["CSF1_fw","5' GCCTGCGTCCGAACTTTCTA"]
["CSF1_rv","5' GTCACCACATCTTGGCTGGA"]
[]
["ENPP2_fw","5' ATGCTTCGGAAAGAAATGGAG"]
["ENPP2_rv","5' TGGAACAGGAATGGAACTGE"]
[]
["FZD6_fw","5' GATCGCTCAGCTCTCGCTC"]
["FZD6_rv","5' CTGGGTCAATTACTCGGGGG"]
[]
["IL10_fw","5' GCGCTGTCATCGATTTCTTCC"]
["IL10_rv","5' GCCACCCTGATGTCTCAGTT"]
[]
["IL10RA_fw","5' CAGACGCTCATGGGACAGAG"]
["IL10RA_rv","5' CAGGGTCTGGCTACAGTTGG"]
[]
["IL6_fw","5' AGGAACAAGCCAGAGCTGTGCAGATG"]
["IL6_rv","5' TTTGTGGTTGGGTCAGGGGTGGTTA"]
[]
["IL6R_fw","5' ACGCCTTGGACAGAATCCAG"]
["IL6R_rv","5' CCTCCAGCAACCAGGAATGT"]
[]
["LIF_fw","5' ACTGGGGATCCCGGCTAA"]
["LIF_rv","5' CACAACTCCTGCCGCC"]
[]
["LIFR_fw","5' GGGAGCGTACCGACTGACT"]
["LIFR_rv","5' ATGAGGAGCCCCCTTTTTCTG"]
[]
["LPAR1_fw","5' CCATCTCTACTTCCATCCCTGTAA"]
["LPAR1_rv","5' ACTCGTTGTAGAAGCACTGTGG"]
[]
["LPAR2_fw","5' ATGGCACCCCTGCTCAGCCGCTCC"]
["LPAR2_rv","5' ACAGCCAGGACATTGCAGGACTCA"]
[]
["LPAR3_fw","5' CGGATCTACGTGTACGTCAAG"]
["LPAR3_rv","5' CCCGGGGTCCAGCATACCACA"]
[]
["LPAR6_fw","5' CCAAGAATTGTGAGAAAGCGACC"]
["LPAR6_rv","5' CCTGCAGTGGATCCCAGATT"]
[]
["LTA4H_fw","5' CAGAGCCATGCCCGAGATAG"]
["LTA4H_rv","5' GTATCCAAAACCAGGCTGCG"]
[]
["PLA2G12A_fw","5' GCC GAG ATG TAC AGA AAA CAC"]
["PLA2G12A_rv","5' GCGGCTCGTTGGCTGTCCAGA"]
[]
["PLA2G7_fw","5' TTCTCATGGTCTTGGGGCATT"]
["PLA2G7_rv","5' AAACCCATGAGATGCCAGGTC"]
[]
["PPARD_fw","5' CGGTGTTCATGCATGTGAG"]
["PPARD_rv","5' AGCTGCGCTCACACTTCTC"]
[]
["PPARG_fw","5' TGCACTGGAATTAGATGACAGC"]
["PPARG_rv","5' TCCGTGACAATCTGTCTGAGG"]
[]
["PTGER2_fw","5' GCTCCTTGCCTTTCACGATTT"]
["PTGER2_rv","5' ACAACAGAGGACTGAACGCA"]
[]
["PTGER4_fw","5' CTCCCTGGTGGTGCTCAT"]
["PTGER4_rv","5' GGCTGATATAACTGGTTGACGA"]
[]
["PTGES_fw","5' TCTGTCGAGCTGATCACACC"]
["PTGES_rv","5' GCAAAGGCCTTCTTCCGCAG"]
[]
["RPL27_fw","5' AAAGCTGTCATCGTGAAGAAC"]
["RPL27_rv","5' GCTGTCACTTTGCGGGGGTAG"]
[]
["S100A13_fw","5' GTGTCCAAAACAAAATGGCCG"]
["S100A13_rv","5' AGACATCAGCTTCTCAACTCTGC"]
[]
["S100A8_fw","5' AGCCCTGCATGTCTCTTGTC"]
["S100A8_rv","5' CTTTCTCCAGCTCGGTCAAC"]
[]
["S100A9_fw","5' AAGAGCTGGTGCGAAAAGAT"]
["S100A9_rv","5' TCAGCTGCTTGTCTGCATTT"]
[]
["TGFB1_fw","5' GCGTGCTAATGGTGGAAAC"]
["TGFB1_rv","5' CGGTGACATCAAAAGATAACCAC"]
[]
["TGFBR1_fw","5' ACTTCCAACTACTGGCCCTT"]
["TGFBR1_rv","5' CGATGGTGAATGACAGTGCG"]
[]
["TGFBR3_fw","5' CTGGTGTGGCATCTGAAGAC"]
["TGFBR3_rv","5' GGACCACAGAACCCTCAGAC"]