name guideSeq guideSpecScore4MM otSeq guideGc readFraction mismatches otScore diffLogo bulgeRnaMmCount bulgeRnaGuideSeq bulgeRnaOtSeq bulgeDnaMmCount bulgeDnaGuideSeq bulgeDnaOtSeq guideOtSum Frock_RAG1B GACTTGTTTTCATTGTTCTCAGG 24 TCCTTGTTTTCATTGTTCTCTGG 35 0.885586742494 2 5.21978021978 **.................. -1 -1 1.0 Kim16_VEGFA2 GACCCCCTCCACCCCGCCTCCGG 29 CTCCCCACCCACCCCGCCTCAGG 80 0.691 4 0.932255747126 **....**............ 1 1 0.691 Cho_ccr5-7 AACACCAGTGAGTAGAGCGGAGG 48 AACACCAGCGAGTAGAGCGGAGG 55 0.42731 1 61.1 ........*........... -2 -2 0.42888 Frock_EMX GAGTCCGAGCAGAAGAAGAAGGG 22 GAGTCTAAGCAGAAGAAGAAGAG 50 0.317464840673 2 2.15689148352 .....**............. -1 -1 0.77161104313 Cho_ccr5-6 ATGAACACCAGTGAGTAGAGCGG 34 ATGAACACCAGCGAGTAGAGCGG 45 0.29448 1 49.2 ...........*........ -2 -2 0.29692 Tsai_VEGFA_site1 GGGTGGGGGGAGTTTGCTCCTGG 41 GGATGGAGGGAGTTTGCTCCTGG 70 0.29254405784 2 4.04915253165 ..*...*............. -1 -1 0.757342973339 Tsai_EMX1 GAGTCCGAGCAGAAGAAGAAGGG 22 GAGTTAGAGCAGAAGAAGAAAGG 50 0.283265306122 2 3.15796703297 ....**.............. -1 -1 0.589931972789 Tsai_FANCF GGAATCCCTTCTGCAGCACCTGG 41 GGAACCCCGTCTGCAGCACCAGG 60 0.263230499122 2 3.67373417722 ....*...*........... -1 -1 0.396037120642 Tsai_HEK293_sgRNA1 GGGAAAGACCCAGCATCCGTGGG 71 GGGAAAGTCCCAGCATCCTTTGG 60 0.243529778609 2 2.93382352941 .......*..........*. -1 -1 0.384159650764 Frock_EMX GAGTCCGAGCAGAAGAAGAAGGG 22 GAGTTAGAGCAGAAGAAGAAAGG 50 0.201367819367 2 3.15796703297 ....**.............. -1 -1 0.77161104313 Frock_RAG1A GCCTCTTTCCCACCCACCTTGGG 33 ACCCCTTCCCCACCTACCTTGGG 60 0.18184388474 4 0.402848101266 *..*...*......*..... 1 1 1.0 Hsu_EMX1.3 GAGTCCGAGCAGAAGAAGAAGGG 22 GAGTCTAAGCAGAAGAAGAAGAG 50 0.180153317 2 2.15689148352 .....**............. -1 -1 0.291483904 Tsai_VEGFA_site1 GGGTGGGGGGAGTTTGCTCCTGG 41 TAGTGGAGGGAGCTTGCTCCTGG 70 0.174875734297 4 0.397317958861 **....*.....*....... 1 1 0.757342973339 Frock_RAG1A GCCTCTTTCCCACCCACCTTGGG 33 TCCTCCTCCCCACCCACCTTCAG 60 0.174516410244 3 1.53882195448 *....*.*............ 0 0 1.0 Ran_EMX1-sg1 GCCTCCCCAAAGCCTGGCCAGGG 23 ACCTCCCCATAGCCTGGCCAGGG 70 0.1714 2 7.41483050847 *........*.......... -1 -1 0.2904 Frock_VEGFA GGGTGGGGGGAGTTTGCTCCTGG 41 GGATGGAGGGAGTTTGCTCCTGG 70 0.150289115936 2 4.04915253165 ..*...*............. -1 -1 0.837736878911 Frock_VEGFA GGGTGGGGGGAGTTTGCTCCTGG 41 TAGTGGAGGGAGCTTGCTCCTGG 70 0.141470653453 4 0.397317958861 **....*.....*....... 1 1 0.837736878911 Tsai_VEGFA_site3 GGTGAGTGAGTGTGTGCGTGTGG 6 AGTGAGTGAGTGTGTGTGTGGGG 60 0.136474801293 2 5.89919354839 *...............*... -1 -1 0.893440475152 Tsai_EMX1 GAGTCCGAGCAGAAGAAGAAGGG 22 GAGTCTAAGCAGAAGAAGAAGAG 50 0.131065759637 2 2.15689148352 .....**............. -1 -1 0.589931972789 Frock_VEGFA GGGTGGGGGGAGTTTGCTCCTGG 41 GGGGAGGGGAAGTTTGCTCCTGG 70 0.116149555665 3 2.34257028112 ...**....*.......... 0 0 0.837736878911 Ran_EMX1-sg1 GCCTCCCCAAAGCCTGGCCAGGG 23 TCCTCCCCACAGCCTGGCCAGGG 70 0.1156 2 7.41483050847 *........*.......... -1 -1 0.2904 Tsai_HEK293_sgRNA3 GGCCCAGACTGAGCACGTGATGG 60 CACCCAGACTGAGCACGTGCTGG 65 0.114535901926 3 1.49209039548 **.................* 0 0 0.273555166374 Frock_RAG1B GACTTGTTTTCATTGTTCTCAGG 24 CATTTGTTTTCATTGTTCTCTGG 35 0.114413257506 2 5.38333333333 *.*................. -1 -1 1.0 Tsai_VEGFA_site3 GGTGAGTGAGTGTGTGCGTGTGG 6 AGAGAGTGAGTGTGTGCATGAGG 60 0.111756485283 3 0.647595061728 *.*..............*.. 0 0 0.893440475152 Tsai_HEK293_sgRNA3 GGCCCAGACTGAGCACGTGATGG 60 GACACAGACCGGGCACGTGAGGG 65 0.107180385289 4 0.648306325301 .*.*.....*.*........ 1 1 0.273555166374 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 TGCACTGCGGCCGGAGGAGGTGG 75 0.102923441594 3 0.323140740741 *..........*.....*.. 0 0 0.956169168712 Tsai_VEGFA_site3 GGTGAGTGAGTGTGTGCGTGTGG 6 TGTGGGTGAGTGTGTGCGTGAGG 60 0.0960782601101 2 6.01265822785 *...*............... -1 -1 0.893440475152 Frock_RAG1A GCCTCTTTCCCACCCACCTTGGG 33 CCCTCCTTCCCACCCACTTTGGG 60 0.0953278514714 3 0.397358024691 *....*...........*.. 0 0 1.0 Frock_RAG1A GCCTCTTTCCCACCCACCTTGGG 33 TCCTCTCTCCCACCCACCTCCGG 60 0.0946917041679 3 1.01909774011 *.....*............* 0 0 1.0 Tsai_VEGFA_site3 GGTGAGTGAGTGTGTGCGTGTGG 6 GCTGAGTGAGTGTATGCGTGTGG 60 0.0872128570181 2 1.50585106383 .*...........*...... -1 -1 0.893440475152 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 GGCTCTGCGGCTGGAGGGGGTGG 75 0.0840021624319 2 2.38717948718 ...*.............*.. -1 -1 0.956169168712 Tsai_HEK293_sgRNA1 GGGAAAGACCCAGCATCCGTGGG 71 GGGAAAAGCCCAGCATCCCTTGG 60 0.0826317430621 3 0.639711267606 ......**..........*. 0 0 0.384159650764 Hsu_EMX1.3 GAGTCCGAGCAGAAGAAGAAGGG 22 GAGTCCTAGCAGGAGAAGAAGAG 50 0.077820488 2 1.76834471831 ......*.....*....... -1 -1 0.291483904 Frock_EMX GAGTCCGAGCAGAAGAAGAAGGG 22 AAGTCTGAGCACAAGAAGAATGG 50 0.0778114890122 3 0.837857777778 *....*.....*........ 0 0 0.77161104313 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 CTACCCCTCCACCCCGCCTCCGG 80 0.0774772599211 3 2.28742368742 ***................. 0 0 0.978266119295 Tsai_VEGFA_site1 GGGTGGGGGGAGTTTGCTCCTGG 41 GGGGAGGGGAAGTTTGCTCCTGG 70 0.0740171712607 3 2.34257028112 ...**....*.......... 0 0 0.757342973339 Kim16_VEGFA1 GGGTGGGGGGAGTTTGCTCCAGG 41 TTGGGGGGGCAGTTTGCTCCTGG 70 0.0719 4 1.31769578313 **.*.....*.......... 1 1 0.0849 Wang_WAS-CR4 TGGATGGAGGAATGAGGAGTTGG 12 GGGAGGGAGGAATGAGGAGTGGG 50 0.0714 2 6.01265822785 *...*............... -1 -1 0.2755 Tsai_VEGFA_site3 GGTGAGTGAGTGTGTGCGTGTGG 6 GGTGAGTGAGTGCGTGCGGGTGG 60 0.067036422395 2 0.815561619718 ............*.....*. -1 -1 0.893440475152 Tsai_FANCF GGAATCCCTTCTGCAGCACCTGG 41 GGAGTCCCTCCTACAGCACCAGG 60 0.0657135690996 3 0.95247721519 ...*.....*..*....... 0 0 0.396037120642 Wang_WAS-CR4 TGGATGGAGGAATGAGGAGTTGG 12 GGGATGGAGGGATGAGGAGTGGG 50 0.0646 2 4.79318181818 *.........*......... -1 -1 0.2755 Tsai_EMX1 GAGTCCGAGCAGAAGAAGAAGGG 22 GAGGCCGAGCAGAAGAAAGACGG 50 0.0634920634921 3 0.194537313433 ...*.............**. 0 0 0.589931972789 Tsai_VEGFA_site3 GGTGAGTGAGTGTGTGCGTGTGG 6 GTTGAGTGAATGTGTGCGTGAGG 60 0.0627565726264 2 6.94404761905 .*.......*.......... -1 -1 0.893440475152 Wang_WAS-CR4 TGGATGGAGGAATGAGGAGTTGG 12 TGGATGGAGGGATGAGGAGTGGG 50 0.0627 1 55.5 ..........*......... -2 -2 0.2755 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 ATTCCCCCCCACCCCGCCTCAGG 80 0.062344039282 4 1.34583333333 ***....*............ 1 1 0.978266119295 Frock_VEGFA GGGTGGGGGGAGTTTGCTCCTGG 41 GGGAGGGTGGAGTTTGCTCCTGG 70 0.0616354239514 2 6.01265822785 ...*...*............ -1 -1 0.837736878911 Frock_RAG1A GCCTCTTTCCCACCCACCTTGGG 33 ACGTCTTCCCCACCCACCTGGGG 60 0.0585255519167 4 0.687682922535 *.*....*...........* 1 1 1.0 Tsai_VEGFA_site3 GGTGAGTGAGTGTGTGCGTGTGG 6 AGTGAATGAGTGTGTGTGTGTGG 60 0.057428596384 3 0.780524691358 *....*..........*... 0 0 0.893440475152 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 GGCACGACGGCTGGAGGTGGGGG 75 0.0571796897742 2 2.15689148352 .....**............. -1 -1 0.956169168712 Frock_RAG1A GCCTCTTTCCCACCCACCTTGGG 33 ACTTCCTTCCCACCCACCTTCAG 60 0.0564993049502 3 1.44751851852 *.*..*.............. 0 0 1.0 Frock_VEGFA GGGTGGGGGGAGTTTGCTCCTGG 41 CGGGGGAGGGAGTTTGCTCCTGG 70 0.0563136438842 3 1.73721552878 *..*..*............. 0 0 0.837736878911 Tsai_HEK293_sgRNA2 GAACACAAAGCATAGACTGCGGG 39 GAACACAATGCATAGATTGCCGG 45 0.0558375634518 2 1.77359722222 ........*.......*... -1 -1 0.0580936266216 Kim/Hap1_VEGFA GGGTGGGGGGAGTTTGCTCCTGG 41 GGATGGAGGGAGTTTGCTCCTGG 70 0.05456 2 4.04915253165 ..*...*............. -1 -1 0.06442 Tsai_VEGFA_site1 GGGTGGGGGGAGTTTGCTCCTGG 41 GGGAGGGTGGAGTTTGCTCCTGG 70 0.0539539087212 2 6.01265822785 ...*...*............ -1 -1 0.757342973339 Frock_RAG1A GCCTCTTTCCCACCCACCTTGGG 33 TCCTCTTCTCCACCCACCTCTGG 60 0.0532950074217 4 0.426140228873 *......**..........* 1 1 1.0 Tsai_VEGFA_site3 GGTGAGTGAGTGTGTGCGTGTGG 6 TGTGAGTAAGTGTGTGTGTGTGG 60 0.051096165604 3 1.29012345679 *......*........*... 0 0 0.893440475152 Frock_EMX GAGTCCGAGCAGAAGAAGAAGGG 22 GAGGCCGAGCAGAAGAAAGACGG 50 0.0508071140017 3 0.194537313433 ...*.............**. 0 0 0.77161104313 Frock_EMX GAGTCCGAGCAGAAGAAGAAGGG 22 AAGCCCGAGCAAAGGAAGAAAGG 50 0.0477395779204 4 0.110193987342 *..*.......*.*...... 1 1 0.77161104313 Tsai_HEK293_sgRNA3 GGCCCAGACTGAGCACGTGATGG 60 AGCTCAGACTGAGCAAGTGAGGG 65 0.0476357267951 3 0.541956882255 *..*...........*.... 0 0 0.273555166374 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 ACACCCCCCCACCCCGCCTCAGG 80 0.047412058279 4 1.34583333333 ***....*............ 1 1 0.978266119295 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 GGCATCACGGCTGGAGGTGGAGG 75 0.0456189961326 3 0.958618437118 ....***............. 0 0 0.956169168712 Frock_RAG1A GCCTCTTTCCCACCCACCTTGGG 33 GTCTCTTTCTCACCCACTTTGGG 60 0.0450957755107 3 0.604903703704 .*.......*.......*.. 0 0 1.0 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 TGCCCCCCCCACCCCACCTCTGG 80 0.0445544554455 4 0.272333333333 **.....*.......*.... 1 1 0.978266119295 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 CTCCCCCCCCACCCCGCCTCAGG 80 0.0424213153023 3 2.54350736278 **.....*............ 0 0 0.978266119295 Frock_VEGFA GGGTGGGGGGAGTTTGCTCCTGG 41 GGGTGGGGGGAGTTTGCCCCAGG 70 0.0418237330923 1 19.6 .................*.. -2 -2 0.837736878911 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 GGCGCTGCGGCGGGAGGTGGAGG 75 0.0416683993845 2 3.70952380952 ...*.......*........ -1 -1 0.956169168712 Frock_RAG1A GCCTCTTTCCCACCCACCTTGGG 33 CACCCTTTCCCATCCACCTTTGG 60 0.0413966967462 4 0.581724683544 **.*........*....... 1 1 1.0 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 GGCACTGAGACTGGGGGTGGGGG 75 0.040836694806 3 0.627808835341 .......*.*....*..... 0 0 0.956169168712 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 AGCAGTGCGGCTAGAGGTGGTGG 75 0.0407951095771 3 1.15070422535 *...*.......*....... 0 0 0.956169168712 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 GCTTCCCTCCACCCCGCATCCGG 80 0.036987845126 4 0.305988666667 .***.............*.. 1 1 0.978266119295 Tsai_HEK293_sgRNA1 GGGAAAGACCCAGCATCCGTGGG 71 GGGAAGGACCCAGCATCCTGGGG 60 0.0361708762083 3 0.250402276119 .....*............** 0 0 0.384159650764 Tsai_EMX1 GAGTCCGAGCAGAAGAAGAAGGG 22 GAGTCCTAGCAGGAGAAGAAGAG 50 0.0353741496599 2 1.76834471831 ......*.....*....... -1 -1 0.589931972789 Frock_RAG1A GCCTCTTTCCCACCCACCTTGGG 33 GCCTCTTCCACACCCACCCTGGG 60 0.0351059067455 3 0.81662 .......*.*........*. 0 0 1.0 Tsai_VEGFA_site3 GGTGAGTGAGTGTGTGCGTGTGG 6 ACTGTGTGAGTGTGTGCGTGAGG 60 0.0347628613853 3 2.42656449553 **..*............... 0 0 0.893440475152 Tsai_VEGFA_site3 GGTGAGTGAGTGTGTGCGTGTGG 6 AGCGAGTGGGTGTGTGCGTGGGG 60 0.0345008297668 3 1.60991195499 *.*.....*........... 0 0 0.893440475152 Tsai_VEGFA_site1 GGGTGGGGGGAGTTTGCTCCTGG 41 CGGGGGAGGGAGTTTGCTCCTGG 70 0.0338906461817 3 1.73721552878 *..*..*............. 0 0 0.757342973339 Wang_WAS-CR4 TGGATGGAGGAATGAGGAGTTGG 12 AGGAGGGAGGAATGGGGAGTTGG 50 0.0333 3 0.844444444444 *...*.........*..... 0 0 0.2755 Frock_VEGFA GGGTGGGGGGAGTTTGCTCCTGG 41 GTGGGGGTAGAGTTTGCTCCAGG 70 0.0330052706091 4 0.833979885057 .*.*...**........... 1 1 0.837736878911 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 GGCACTGCTGCTGGGGGTGGTGG 75 0.0328107456232 2 1.0954971831 ........*.....*..... -1 -1 0.956169168712 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 TACCCCCCACACCCCGCCTCTGG 80 0.0323190855671 3 1.63277074543 *......**........... 0 0 0.978266119295 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 TGCCCCTCCCACCCCGCCTCTGG 80 0.0318361104403 4 0.932255747126 **....**............ 1 1 0.978266119295 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 GACCCCTCCCACCCCGACTCCGG 80 0.0308701601868 3 0.74016962963 ......**........*... 0 0 0.978266119295 Tsai_VEGFA_site3 GGTGAGTGAGTGTGTGCGTGTGG 6 AGTGTGTGAGTGTGTGCGTGTGG 60 0.0299589483798 2 6.01265822785 *...*............... -1 -1 0.893440475152 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 GGCACTGGGGCTGGGGGAGGGGG 75 0.0296086829958 3 0.147856592593 .......*......*..*.. 0 0 0.956169168712 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 GTACCCCACCACCCCGCCCCAGG 80 0.0293004910247 4 0.4917675 .**....*..........*. 1 1 0.978266119295 Tsai_VEGFA_site1 GGGTGGGGGGAGTTTGCTCCTGG 41 CTGGTGGGGGAGCTTGCTCCAGG 70 0.0292815183009 5 0.354361445783 **.**.......*....... 2 2 0.757342973339 Hsu_EMX1.1 GTCACCTCCAATGACTAGGGTGG 68 GCTACCTCCAGTGACTAGGGAAG 55 0.029040975 3 1.46235864979 .**.......*......... 0 0 0.030092945 Frock_VEGFA GGGTGGGGGGAGTTTGCTCCTGG 41 GAGGGGGAGCAGTTTGCTCCAGG 70 0.0285448684053 4 1.25711206897 .*.*...*.*.......... 1 1 0.837736878911 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 CCCCACCCCCACCCCGCCTCAGG 80 0.0283345407712 4 1.36494252874 **..*..*............ 1 1 0.978266119295 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 CCCCCCCCCCCCCCCGCCTCCGG 80 0.0283345407712 4 0.794051204819 **.....*..*......... 1 1 0.978266119295 Kim/K562_VEGFA GGGTGGGGGGAGTTTGCTCCTGG 41 GGATGGAGGGAGTTTGCTCCTGG 70 0.02824 2 4.04915253165 ..*...*............. -1 -1 0.032 Tsai_VEGFA_site3 GGTGAGTGAGTGTGTGCGTGTGG 6 TGTGGGTGAGTGTGTGCGTGAGA 60 0.028081055114 2 6.01265822785 *...*............... -1 -1 0.893440475152 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 GGCACTGGGGTTGGAGGTGGGGG 75 0.0276125920073 2 3.17620481928 .......*..*......... -1 -1 0.956169168712 Cho_ccr5-8 CCAGTGAGTAGAGCGGAGGCAGG 37 CCAGCGAGTAGAGCGGAGGCAGG 65 0.02755 1 100.0 ....*............... -2 -2 0.02848 Frock_EMX GAGTCCGAGCAGAAGAAGAAGGG 22 GAGTCCTAGCAGGAGAAGAAGAG 50 0.0274066748244 2 1.76834471831 ......*.....*....... -1 -1 0.77161104313 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 AGGACTGCGGCTGGGGGTGGTGG 75 0.0272799101759 3 0.832622222222 *.*...........*..... 0 0 0.956169168712 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 GGCACTGAGGGTGGAGGTGGGGG 75 0.0270303988023 2 3.17620481928 .......*..*......... -1 -1 0.956169168712 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 GACACCACGGCTGGAGATGGTGG 75 0.0267808874288 4 0.251888977083 .*...**.........*... 1 1 0.956169168712 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 CACCCCCCCCCCCCCACCTCCGG 80 0.0252354503743 4 0.151145 *......*..*....*.... 1 1 0.978266119295 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 CCTCCCCCACACCCCGCATCCGG 80 0.0251549545198 6 0.0750839659973 ***....**........*.. 3 3 0.978266119295 Hsu_EMX1.3 GAGTCCGAGCAGAAGAAGAAGGG 22 GAGGCCGAGCAGAAGAAAGACGG 50 0.0245892 3 0.194537313433 ...*.............**. 0 0 0.291483904 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 CCCCCTCCCCGCCCCGCCCCCGG 80 0.0242695001207 6 0.0672561370482 **...*.*..*.......*. 3 3 0.978266119295 Tsai_EMX1 GAGTCCGAGCAGAAGAAGAAGGG 22 AAGTCTGAGCACAAGAAGAATGG 50 0.0234013605442 3 0.837857777778 *....*.....*........ 0 0 0.589931972789 Tsai_VEGFA_site1 GGGTGGGGGGAGTTTGCTCCTGG 41 GGGTGGGGGGAGTTTGCCCCAGG 70 0.0225033890646 1 19.6 .................*.. -2 -2 0.757342973339 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 GGCACTGTGGCTGCAGGTGGAGG 75 0.0224144383915 2 0.996830985915 .......*.....*...... -1 -1 0.956169168712 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 AGCACTGTGGCTGGGGGAGGGGG 75 0.0222896827047 4 0.0831693333333 *......*......*..*.. 1 1 0.956169168712 Tsai_VEGFA_site1 GGGTGGGGGGAGTTTGCTCCTGG 41 GCGTGGGGGGTGTTTGCTCCCGG 70 0.0222322638952 2 4.46822033898 .*........*......... -1 -1 0.757342973339 Tsai_VEGFA_site1 GGGTGGGGGGAGTTTGCTCCTGG 41 GTGGGGGTAGAGTTTGCTCCAGG 70 0.0217803886127 4 0.833979885057 .*.*...**........... 1 1 0.757342973339 Tsai_EMX1 GAGTCCGAGCAGAAGAAGAAGGG 22 GAGTCCGGGAAGGAGAAGAAAGG 50 0.0195918367347 3 0.864893103448 .......*.*..*....... 0 0 0.589931972789 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 GGGCCCCTCCACCCCGCCTCTGG 80 0.0194397488529 2 5.1467032967 .**................. -1 -1 0.978266119295 Frock_RAG1A GCCTCTTTCCCACCCACCTTGGG 33 GCCTCTTTACCACCTCACCTTGG 60 0.0189194920246 5 0.00298380250444 ........*.....***.*. 2 1 GCCTCTTTCCCACCCACCTTGG GCCTCTTTACCACC(T)CACCTTGG 1.0 Tsai_FANCF GGAATCCCTTCTGCAGCACCTGG 41 AGAGGCCCCTCTGCAGCACCAGG 60 0.0188111361926 4 0.833979885057 *..**...*........... 1 1 0.396037120642 Frock_RAG1A GCCTCTTTCCCACCCACCTTGGG 33 TTCTCTTCCCCACCCACCTTTGA 60 0.0185425158448 3 2.54350736278 **.....*............ 0 0 1.0 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 GGCAATGTGGCTGAAGGTGGGGG 75 0.0185054268724 3 0.398171589311 ....*..*.....*...... 0 0 0.956169168712 Cho_ccr5-4 AAATGAGAAGAAGAGGCACAGGG 10 AAACGAGAAGAAGAGGCATAGGG 40 0.01824 2 4.275 ...*..............*. -1 -1 0.02015 Frock_RAG1A GCCTCTTTCCCACCCACCTTGGG 33 TCCTCTTCTCCACCCACCATAGG 60 0.0181184176425 4 0.321904489437 *......**.........*. 1 1 1.0 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 CGCCCTCCCCACCCCGCCTCCGG 80 0.0179505755454 4 0.825790229885 **...*.*............ 1 1 0.978266119295 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 GACACACCCCACCCCACCTCAGG 80 0.0166626418739 4 0.156419303797 ...*.*.*.......*.... 1 1 0.978266119295 Frock_VEGFA GGGTGGGGGGAGTTTGCTCCTGG 41 GCGTGGGGGGTGTTTGCTCCCGG 70 0.0164855783172 2 4.46822033898 .*........*......... -1 -1 0.837736878911 Cho_ccr5-5 CCTGCCTCCGCTCTACTCACTGG 43 CCTGCCTCCGCTCTACTCGCTGG 65 0.01637 1 31.5 ..................*. -2 -2 0.0169 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 GACCCCCCCCACCCCGCCCCCGG 80 0.0157369395476 2 2.93382352941 .......*..........*. -1 -1 0.978266119295 Tsai_FANCF GGAATCCCTTCTGCAGCACCTGG 41 ACCATCCCTCCTGCAGCACCAGG 60 0.0156759468272 4 1.29924804217 ***......*.......... 1 1 0.396037120642 Frock_VEGFA GGGTGGGGGGAGTTTGCTCCTGG 41 CTGGTGGGGGAGCTTGCTCCAGG 70 0.0153854026302 5 0.354361445783 **.**.......*....... 2 2 0.837736878911 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 GGCACAGCAGCTGGAGGTGCTGG 75 0.0153449494739 3 0.485700922886 .....*..*..........* 0 0 0.956169168712 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 GCCACTGGGGCTGGGGGTGGGGG 75 0.0150122676425 3 0.796870109546 .*.....*......*..... 0 0 0.956169168712 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 TCCCCCCCACCCCCCACCTCAGG 80 0.0146904934396 6 0.0370881907631 **.....**.*....*.... 3 3 0.978266119295 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 TGCACTGTGGCTGGAGATGGGGG 75 0.0146380005822 3 1.29012345679 *......*........*... 0 0 0.956169168712 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 GACACCTTCCACCCCGTCTCTGG 80 0.0145697496579 3 0.781869327074 ...*..*.........*... 0 0 0.978266119295 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 GCCCCCACCCACCCCGCCTCTGG 80 0.0143685100217 3 1.73721552878 .*....**............ 0 0 0.978266119295 Frock_VEGFA GGGTGGGGGGAGTTTGCTCCTGG 41 AGGAAGGAGGAGTTAGCTCCTGG 70 0.0142084704999 5 0.245397590361 *..**..*......*..... 2 2 0.837736878911 Frock_RAG1A GCCTCTTTCCCACCCACCTTGGG 33 GTCTCTTTCCCATCCACCTTTGA 60 0.0141601677544 2 3.60441176471 .*..........*....... -1 -1 1.0 Frock_EMX GAGTCCGAGCAGAAGAAGAAGGG 22 GAGTCCGGGAAGGAGAAGAAAGG 50 0.0135943812126 3 0.864893103448 .......*.*..*....... 0 0 0.77161104313 Frock_VEGFA GGGTGGGGGGAGTTTGCTCCTGG 41 GGTGGGGGTGGGTTTGCTCCTGG 70 0.0135261910041 4 0.4563788125 ..**....*.*......... 1 1 0.837736878911 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 CATCCCCCCCACCCCACCCCGGG 80 0.0135233035499 5 0.0513928162025 *.*....*.......*..*. 2 2 0.978266119295 Kim/Hap1_HBB CTTGCCCCACAGGGCAGTAACGG 46 TCAGCCCCACAGGGCAGTAAGGG 60 0.01343 3 2.28742368742 ***................. 0 0 0.01391 Frock_VEGFA GGGTGGGGGGAGTTTGCTCCTGG 41 GGGCAAGGGGAGGTTGCTCCTGG 70 0.0133300356491 4 0.334982304217 ...***......*....... 1 1 0.837736878911 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 CTGCCCCCCCACCCCGCCACTGG 80 0.0132818159865 5 0.298795443038 ***....*..........*. 2 2 0.978266119295 Frock_RAG1A GCCTCTTTCCCACCCACCTTGGG 33 GCCCCTACCCCACCCACCTGGGT 60 0.0132412883161 4 0.45095075 ...*..**...........* 1 1 1.0 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 GGCTCTGTGGCTGGAGGAGGTGG 75 0.0131409323408 3 0.617578772803 ...*...*.........*.. 0 0 0.956169168712 Tsai_EMX1 GAGTCCGAGCAGAAGAAGAAGGG 22 GAGCCGGAGCAGAAGAAGGAGGG 50 0.012970521542 3 0.600485074627 ...*.*............*. 0 0 0.589931972789 Frock_VEGFA GGGTGGGGGGAGTTTGCTCCTGG 41 AGGTGGTGGGAGCTTGTTCCTGG 70 0.0128950824705 4 0.16112567625 *.....*.....*...*... 1 1 0.837736878911 Tsai_FANCF GGAATCCCTTCTGCAGCACCTGG 41 GGATTGCCATCCGCAGCACCTGG 60 0.0126661650364 4 0.248242452586 ...*.*..*..*........ 1 1 0.396037120642 Wang_WAS-CR4 TGGATGGAGGAATGAGGAGTTGG 12 CGGACGGAGGAATGGGGAGTGGG 50 0.0124 3 0.844444444444 *...*.........*..... 0 0 0.2755 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 GCCACTGCAGCTAGAGGTGGAGG 75 0.0123508129912 3 0.665582666667 .*......*...*....... 0 0 0.956169168712 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 CCCCCCCCCCCCCCCGCCTCAGG 80 0.0121951219512 4 0.794051204819 **.....*..*......... 1 1 0.978266119295 Frock_VEGFA GGGTGGGGGGAGTTTGCTCCTGG 41 GGAGGAGGGGAGTCTGCTCCAGG 70 0.0119569481638 4 0.127166899849 ..**.*.......*...... 1 1 0.837736878911 Wang_WAS-CR4 TGGATGGAGGAATGAGGAGTTGG 12 GAGGATGGGGAATGAGGAGTAGG 50 0.0118 6 0.350885225885 **.***.*............ 2 TGGATGG(A)GGAATGAGGAGTTGG AGGATGGGGAATGAGGAGTAGG 3 0.2755 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 GCCCCCCACCACCCCACCTCGGG 80 0.0117121468244 3 0.541956882255 .*.....*.......*.... 0 0 0.978266119295 Tsai_HEK293_sgRNA1 GGGAAAGACCCAGCATCCGTGGG 71 GGGAAATACCCAGCATCCAATGG 60 0.0115372622389 3 0.266759598592 ......*...........** 0 0 0.384159650764 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 CCCCCCCCCCCCCCCGCCCCGGG 80 0.0111889237704 5 0.168186075949 **.....*..*.......*. 2 2 0.978266119295 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 TGCCCCCCCCACCCCGCCCCCGG 80 0.0105852048619 4 0.526848591549 **.....*..........*. 1 1 0.978266119295 Frock_RAG1A GCCTCTTTCCCACCCACCTTGGG 33 ACCTCTTATCCACCCACCTTGGC 60 0.0105788940461 3 1.63277074543 *......**........... 0 0 1.0 Frock_VEGFA GGGTGGGGGGAGTTTGCTCCTGG 41 AGCTGAGGGGAGCTTGCTCTGGG 70 0.0104985757416 5 0.0926116902547 *.*..*......*......* 2 2 0.837736878911 Frock_EMX GAGTCCGAGCAGAAGAAGAAGGG 22 GAGCCGGAGCAGAAGAAGGAGGG 50 0.0104095076856 3 0.600485074627 ...*.*............*. 0 0 0.77161104313 Tsai_VEGFA_site1 GGGTGGGGGGAGTTTGCTCCTGG 41 GAGGGTGGGGAGTTTACTCCTGG 70 0.0103931314957 4 0.156419303797 .*.*.*.........*.... 1 1 0.757342973339 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 GGCACTGCGGGTGGAGGCGGGGG 75 0.0103547220027 2 0.771201492537 ..........*......*.. -1 -1 0.956169168712 Frock_VEGFA GGGTGGGGGGAGTTTGCTCCTGG 41 GAGTGGGTGGAGTTTGCTACAGG 70 0.0103365343613 3 1.05555555556 .*.....*..........*. 0 0 0.837736878911 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 CTTCCCCCACACCCCGCCCCAGG 80 0.0103034693713 6 0.120670659639 ***....**.........*. 3 3 0.978266119295 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 AGGCCCCCCCGCCCCGCCTCAGG 80 0.0101424776624 5 0.47804 ***....*..*......... 2 2 0.978266119295 Frock_VEGFA GGGTGGGGGGAGTTTGCTCCTGG 41 GGTTGAGGGGAGTCTGCTCCAGG 70 0.010063622563 3 0.250189100741 ..*..*.......*...... 0 0 0.837736878911 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 AGCACTGTGCCTGGGGGTGGGGG 75 0.0100220401713 4 0.371023101266 *......*.*....*..... 1 1 0.956169168712 Frock_RAG1A GCCTCTTTCCCACCCACCTTGGG 33 GCCTCTCCCCACCCACCCTTGGC 60 0.0100134297764 6 0.0049859938487 ......**..**..**.... 3 3 1.0 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 GGCAATGCGGCTGGAGGCGGAGG 75 0.0099804549424 2 2.16511627907 ....*............*.. -1 -1 0.956169168712 Frock_EMX GAGTCCGAGCAGAAGAAGAAGGG 22 GAATCCAAGCAGAAGAAGAGAAG 50 0.00997368288717 3 0.941031617989 ..*...*............* 0 0 0.77161104313 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 TACCCCCCCCACCCCGCCACAGG 80 0.00990099009901 3 1.12711864407 *......*..........*. 0 0 0.978266119295 Tsai_FANCF GGAATCCCTTCTGCAGCACCTGG 41 TGAATCCCATCTCCAGCACCAGG 60 0.00978179082017 3 0.70308028169 *.......*...*....... 0 0 0.396037120642 Tsai_FANCF GGAATCCCTTCTGCAGCACCTGG 41 GGAGTCCCTCCTACAGCACCAGG 60 0.00965638324555 3 0.95247721519 ...*.....*..*....... 0 0 0.396037120642 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 CATACCCCCCACCCCGCCCCGGG 80 0.00945826289946 5 0.298795443038 *.**...*..........*. 2 2 0.978266119295 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 GAGGCTGCGGCTGGGGGTGGAGG 75 0.00943984696636 4 0.397208227848 .***..........*..... 1 1 0.956169168712 Tsai_VEGFA_site3 GGTGAGTGAGTGTGTGCGTGTGG 6 CGCGAGTGAGTGTGTGCGCGGGG 60 0.00938946632894 3 1.11133898305 *.*...............*. 0 0 0.893440475152 Tsai_EMX1 GAGTCCGAGCAGAAGAAGAAGGG 22 AAGTCCGAGGAGAGGAAGAAAGG 50 0.00925170068027 3 0.408036150235 *........*...*...... 0 0 0.589931972789 Frock_EMX GAGTCCGAGCAGAAGAAGAAGGG 22 AAGTCAGAGCAGAAAAAGAGAGG 50 0.00906850830581 4 0.113084086268 *....*........*....* 1 1 0.77161104313 Frock_VEGFA GGGTGGGGGGAGTTTGCTCCTGG 41 GGGTGGGTGGAGTTTGCTACTGG 70 0.00887816193904 2 2.93382352941 .......*..........*. -1 -1 0.837736878911 Tsai_VEGFA_site3 GGTGAGTGAGTGTGTGCGTGTGG 6 GGTGAGTGAGTGTGTGTGTGAGG 60 0.00869071534632 1 38.5 ................*... -2 -2 0.893440475152 Frock_VEGFA GGGTGGGGGGAGTTTGCTCCTGG 41 AGGGAGGAGGAATTTGCTCCAGG 70 0.00849437972265 5 0.429793103448 *..**..*...*........ 2 2 0.837736878911 Tsai_VEGFA_site3 GGTGAGTGAGTGTGTGCGTGTGG 6 CTGGAGTGAGTGTGTGTGTGTGG 60 0.00842868372784 4 0.601049166667 ***.............*... 1 1 0.893440475152 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 GGCTCCGCAGCTGGAGGTGGGGG 75 0.00835863101426 3 0.896991698595 ...*.*..*........... 0 0 0.956169168712 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 AGCACTGTGGCTGGGGGAGGCGG 75 0.00823387532748 4 0.0831693333333 *......*......*..*.. 1 1 0.956169168712 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 CGCCCTCCCCACTCCGCCTCGGG 80 0.00813008130081 5 0.214388674699 **...*.*....*....... 2 2 0.978266119295 Frock_RAG1A GCCTCTTTCCCACCCACCTTGGG 33 ACCTCCTTCCCGCCCACCTGGGG 60 0.00808142685484 4 0.207602128521 *....*.....*.......* 1 1 1.0 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 GTCACTGCAGCTGGAGGAGGGGG 75 0.00806753441178 3 0.401298765432 .*......*........*.. 0 0 0.956169168712 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 AGCACGGCAGCTGGAGGAGGGGG 75 0.00798436395392 4 0.114716268333 *....*..*........*.. 1 1 0.956169168712 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 GGCTCTGAGGCCAGAGGTGGTGG 75 0.00798436395392 4 0.272415361446 ...*...*...**....... 1 1 0.956169168712 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 GAGCTCCCCCACCCCGCCCCGGG 80 0.0077276020285 4 0.4917675 ..*.*..*..........*. 1 1 0.978266119295 Kim/K562_HBB CTTGCCCCACAGGGCAGTAACGG 46 TCAGCCCCACAGGGCAGTAAGGG 60 0.00767 3 2.28742368742 ***................. 0 0 0.00791 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 AGCACTGCAGCTGGGAGTGGAGG 75 0.00744375597788 4 0.0445940386667 *.......*.....**.... 1 1 0.956169168712 Frock_VEGFA GGGTGGGGGGAGTTTGCTCCTGG 41 GGGGGTGGGGACTTTGCTCCAGG 70 0.00737714704829 3 0.795434599156 ...*.*.....*........ 0 0 0.837736878911 Frock_RAG1A GCCTCTTTCCCACCCACCTTGGG 33 ACCCCTTCCCCACTCACCTCCGG 60 0.00735103550644 5 0.0597735189873 *..*...*.....*.....* 2 2 1.0 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 GACCCCTCACACCCCGCCCCTGG 80 0.00720437897448 4 0.197596384889 ......***.........*. 1 1 0.978266119295 Kim16_VEGFA1 GGGTGGGGGGAGTTTGCTCCAGG 41 AGGGAGGAGGAATTTGCTCCAGG 70 0.0072 5 0.429793103448 *..**..*...*........ 2 2 0.0849 Cho_ccr5-2 GACACCGAAGCAGAGTTTTTAGG 50 GACAATAAAGCAGAGTTTTTTGG 45 0.00697 3 0.958618437118 ....***............. 0 0 0.01731 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 GGGACTGCGGCTGGAGGTGGGAA 75 0.0068615627729 1 98.6 ..*................. -2 -2 0.956169168712 Frock_VEGFA GGGTGGGGGGAGTTTGCTCCTGG 41 GGGCAGAGGGAGTTAGCACCGGG 70 0.00678015248947 5 0.0328508846265 ...**.*.......*..*.. 2 2 0.837736878911 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 GGCACTGCTGCTAGAGGTGCAGG 75 0.00677839231505 3 0.277547972 ........*...*......* 0 0 0.956169168712 Frock_RAG1A GCCTCTTTCCCACCCACCTTGGG 33 GCTTCTTCCCCACCCACACTTGG 60 0.00664420516929 4 0.09638643 ..*....*.........**. 1 1 1.0 Tsai_VEGFA_site3 GGTGAGTGAGTGTGTGCGTGTGG 6 AGCGAGTGAGTGTGTGTGTGGGG 60 0.00650711852564 3 1.2720617284 *.*.............*... 0 0 0.893440475152 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 CCCCCCCACCACCCCGCCCCGGG 80 0.00643966835708 4 0.526848591549 **.....*..........*. 1 1 0.978266119295 Tsai_EMX1 GAGTCCGAGCAGAAGAAGAAGGG 22 GAATCCAAGCAGGAGAAGAAGGA 50 0.00607709750567 3 0.733598461333 ..*...*.....*....... 0 0 0.589931972789 Wang_WAS-CR4 TGGATGGAGGAATGAGGAGTTGG 12 TGGATGGAAGAATGAGGGGTGGG 50 0.006 2 0.964137288136 ........*........*.. -1 -1 0.2755 Wang_WAS-CR4 TGGATGGAGGAATGAGGAGTTGG 12 ACGATGGAGGAATGAGGACTTGG 50 0.0058 3 1.12711864407 **................*. 0 0 0.2755 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 GGCTGTGCGGCCAGAGGTGGAGG 75 0.00573876159188 4 0.272415361446 ...**......**....... 1 1 0.956169168712 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 CTCCCCCGCCACCCCGCCCCAGG 80 0.00567495773968 4 0.526848591549 **.....*..........*. 1 1 0.978266119295 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 CCACCCCCCCACCCCGCCCCTGG 80 0.00555421395798 5 0.298795443038 ***....*..........*. 2 2 0.978266119295 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 GACCCTGTCCACCCCACCTCAGG 80 0.00543347017629 3 0.200057277037 .....**........*.... 0 0 0.978266119295 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 TCCACCCCCCACCCCGCCCCGGG 80 0.00543347017629 5 0.303037974684 **.*...*..........*. 2 2 0.978266119295 Frock_RAG1A GCCTCTTTCCCACCCACCTTGGG 33 CACCCTTCCCCACCCACCCTGGG 60 0.00534834955116 5 0.303037974684 **.*...*..........*. 2 2 1.0 Tsai_VEGFA_site3 GGTGAGTGAGTGTGTGCGTGTGG 6 GGTGAGTCAGTGTGTGAGTGAGG 60 0.00532797624247 2 3.09957627119 .......*........*... -1 -1 0.893440475152 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 GACACTGAGGCAGGAGGTGGGGG 75 0.00528132407369 3 1.38488888889 .*.....*...*........ 0 0 0.956169168712 Tsai_VEGFA_site1 GGGTGGGGGGAGTTTGCTCCTGG 41 GGAGGAGGGGAGTCTGCTCCAGG 70 0.0052417532761 4 0.127166899849 ..**.*.......*...... 1 1 0.757342973339 Frock_VEGFA GGGTGGGGGGAGTTTGCTCCTGG 41 AAGTAAGGGAAGTTTGCTCCTGG 70 0.00521090964914 5 0.486753793103 **..**...*.......... 2 2 0.837736878911 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 CACTCCCCCCACCCCGCCCCAGG 80 0.00515173468566 4 0.526848591549 *..*...*..........*. 1 1 0.978266119295 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 GGCACAATGGCTGGAGGTGAAGG 75 0.00511498315798 4 0.259011269383 .....***...........* 1 1 0.956169168712 Wang_WAS-CR5 CCCTGTGTCTCTGGATGGATGGG 42 CCCTGTGTCTCTGGGTGGAAGAG 55 0.0051 2 0.707788 ..............*....* -1 -1 0.0051 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 AGCCCCCCCCACCCCGACTCAGG 80 0.0050712388312 4 0.609583333333 **.....*........*... 1 1 0.978266119295 Tsai_VEGFA_site3 GGTGAGTGAGTGTGTGCGTGTGG 6 GGTGTGTGAGTGTGTGTGTGTGG 60 0.00502227268757 2 3.89095744681 ....*...........*... -1 -1 0.893440475152 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 CATTCCCCCCACCCCACCTCAGG 80 0.0049504950495 5 0.155289060241 *.**...*.......*.... 2 2 0.978266119295 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 AGCACTGGGGCTGGGGGAGGGGG 75 0.00494864224228 4 0.0831693333333 *......*......*..*.. 1 1 0.956169168712 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 CCCCCCCCCCGCCCCGCCCCCCG 80 0.00491024712227 5 0.168186075949 **.....*..*.......*. 2 2 0.978266119295 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 ATCCCCCTCCACCCCACCCCTGG 80 0.00486999919504 4 0.0906179577465 **.............*..*. 1 1 0.978266119295 Frock_VEGFA GGGTGGGGGGAGTTTGCTCCTGG 41 AGGAAGGAGGAGTTAGCTCCTGG 70 0.00485271291385 5 0.245397590361 *..**..*......*..... 2 2 0.837736878911 Tsai_VEGFA_site3 GGTGAGTGAGTGTGTGCGTGTGG 6 TGTGAGTGAGTGTGTGTGTGTGA 60 0.00484758494192 2 5.89919354839 *...............*... -1 -1 0.893440475152 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 GACACCGTGACTGGAGGTGGAGG 75 0.0048238865555 4 0.760552801724 .*...*.*.*.......... 1 1 0.956169168712 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 GGCACTGCCACTGGGGGTGAGGG 75 0.0048238865555 4 0.0899761104732 ........**....*....* 1 1 0.956169168712 Frock_VEGFA GGGTGGGGGGAGTTTGCTCCTGG 41 AGGAAGGAGGAGTTAGCTCCTGG 70 0.00470772852099 5 0.245397590361 *..**..*......*..... 2 2 0.837736878911 Kim16_EMX1 GAGTCCGAGCAGAAGAAGAAGGG 22 AAGTCAGAGGAGAAGAAGAAGGG 50 0.0047 3 1.48901476793 *....*...*.......... 0 0 0.0068 Frock_RAG1A GCCTCTTTCCCACCCACCTTGGG 33 GCCCCTCCCCCACCCACCCTGGG 60 0.00459439719153 4 0.34064625 ...*..**..........*. 1 1 1.0 Tsai_VEGFA_site1 GGGTGGGGGGAGTTTGCTCCTGG 41 GGTGGGGGTGGGTTTGCTCCTGG 70 0.00451875282422 4 0.4563788125 ..**....*.*......... 1 1 0.757342973339 Tsai_VEGFA_site3 GGTGAGTGAGTGTGTGCGTGTGG 6 TGTGAGTGAGTGTGTGTATGGGG 60 0.00449820945061 3 0.252864197531 *...............**.. 0 0 0.893440475152 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 CACACTGCAGCTGGAGGTGGTGG 75 0.00449120472408 3 1.63277074543 **......*........... 0 0 0.956169168712 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 CAACCCCCCCACCCCGCTTCAGG 80 0.00446751992272 4 0.305988666667 *.*....*.........*.. 1 1 0.978266119295 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 CCCCCCCCCCACCCCGCCCCCGG 80 0.00434677614103 4 0.526848591549 **.....*..........*. 1 1 0.978266119295 Frock_VEGFA GGGTGGGGGGAGTTTGCTCCTGG 41 AGCTGGAGGGAGTTTGCCCCAGG 70 0.00428983232981 4 0.208990259333 *.*...*..........*.. 1 1 0.837736878911 Frock_RAG1A GCCTCTTTCCCACCCACCTTGGG 33 TGCTCTTCCCCACCCACCCAAGG 60 0.00428810404543 5 0.126366835443 **.....*..........** 2 2 1.0 Tsai_VEGFA_site1 GGGTGGGGGGAGTTTGCTCCTGG 41 GAGGGGGAGCAGTTTGCTCCAGG 70 0.00424762765477 4 1.25711206897 .*.*...*.*.......... 1 1 0.757342973339 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 AGCACTGCAGATGGAGGAGGCGG 75 0.00424169335052 4 0.105235585 *.......*.*......*.. 1 1 0.956169168712 Tsai_VEGFA_site3 GGTGAGTGAGTGTGTGCGTGTGG 6 AGTGAGTGAGTGAGTGAGTGAGG 60 0.00423617783213 3 0.499277777778 *...........*...*... 0 0 0.893440475152 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 GGCTCTGTGGCCGGAGGAGGCGG 75 0.00411693766374 4 0.144953164557 ...*...*...*.....*.. 1 1 0.956169168712 Tsai_HEK293_sgRNA1 GGGAAAGACCCAGCATCCGTGGG 71 CAAGAAGACCCAGCTTCCGTAGG 60 0.00405363267852 5 0.241962024096 ****..........*..... 2 2 0.384159650764 Frock_VEGFA GGGTGGGGGGAGTTTGCTCCTGG 41 GAGGGTGGGGAGTTTACTCCTGG 70 0.00402544902519 4 0.156419303797 .*.*.*.........*.... 1 1 0.837736878911 Wang_WAS-CR4 TGGATGGAGGAATGAGGAGTTGG 12 GCGATGGAGGAATGAAGAGTTGG 50 0.004 3 0.541956882255 **.............*.... 0 0 0.2755 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 CCACCCCCCCACCCCGCCCCAGG 80 0.00394429686871 5 0.298795443038 ***....*..........*. 2 2 0.978266119295 Kim/Hap1_VEGFA GGGTGGGGGGAGTTTGCTCCTGG 41 TAGTGGAGGGAGCTTGCTCCTGG 70 0.00387 4 0.397317958861 **....*.....*....... 1 1 0.06442 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 CTCCCTCCCCACCCCACCTCTGG 80 0.00382355308702 5 0.0952838554217 **...*.*.......*.... 2 2 0.978266119295 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 GGCACTTCGGTTGGGGGTGGGGG 75 0.00378425583233 3 0.271476649789 ......*...*...*..... 0 0 0.956169168712 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 GCCACTGCGACTGGAGGAGGGGG 75 0.0037426706034 3 0.604903703704 .*.......*.......*.. 0 0 0.956169168712 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 AGGCCCCCACACCCCGCCTCAGG 80 0.00370280930532 5 0.526274666667 ***....**........... 2 2 0.978266119295 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 GGCGCTGCGGCCGGAGGTGGGGC 75 0.00370108537447 2 3.70952380952 ...*.......*........ -1 -1 0.956169168712 Frock_RAG1A GCCTCTTTCCCACCCACCTTGGG 33 ACCTCCATCCTCCCCACCTTGGG 60 0.00362839573074 5 0.098566311269 *....**...**........ 2 2 1.0 Tsai_VEGFA_site3 GGTGAGTGAGTGTGTGCGTGTGG 6 TGTGGGTGAGCATGTGCGTGAGG 60 0.00362477072233 4 0.390673192771 *...*.....**........ 1 1 0.893440475152 Kim/Hap1_VEGFA GGGTGGGGGGAGTTTGCTCCTGG 41 GGGTGGGGGGAGTTTGCCCCAGG 70 0.0036 1 19.6 .................*.. -2 -2 0.06442 Tsai_VEGFA_site3 GGTGAGTGAGTGTGTGCGTGTGG 6 GTAGAGTGAGTGTGTGTGTGTGG 60 0.00358109878592 3 1.19611774461 .**.............*... 0 0 0.893440475152 Tsai_HEK293_sgRNA3 GGCCCAGACTGAGCACGTGATGG 60 AGACCAGACTGAGCAAGAGAGGG 65 0.00350262697023 4 0.0526300506667 *.*............*.*.. 1 1 0.273555166374 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 ACCCCCCCCCCCCCCGCCCCCGG 80 0.00350156966916 5 0.168186075949 **.....*..*.......*. 2 2 0.978266119295 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 GCCCCCCCCAACCCCGCCCCCGG 80 0.00350156966916 4 0.45934875 .*.....*.*........*. 1 1 0.978266119295 Hsu_EMX1.3 GAGTCCGAGCAGAAGAAGAAGGG 22 AAGTCCGAGGAGAGGAAGAAAGG 50 0.00349731 3 0.408036150235 *........*...*...... 0 0 0.291483904 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 CCCACTGGGGCTGGAGGTGGGGG 75 0.00345157400091 3 2.54350736278 **.....*............ 0 0 0.956169168712 Tsai_EMX1 GAGTCCGAGCAGAAGAAGAAGGG 22 ACGTCTGAGCAGAAGAAGAATGG 50 0.00344671201814 3 1.4680715198 **...*.............. 0 0 0.589931972789 Frock_RAG1A GCCTCTTTCCCACCCACCTTGGG 33 GGCTCCTCCTCACCCACCTCTGG 60 0.00336922460712 5 0.223530896962 .*...*.*.*.........* 2 2 1.0 Frock_RAG1A GCCTCTTTCCCACCCACCTTGGG 33 GACTCTTTTCCACCCACCCTAGG 60 0.0032985415734 3 0.644944444444 .*......*.........*. 0 0 1.0 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 GGCACTGCAGCCTGGGGGTGGGG 75 0.00324364785628 6 0.00116775179833 ........*..**.*..**. 3 2 GGCACTGCGGCTGGAGGTGGGG GGCACTGC(A)GCCTGGGGGTGGGG 0.956169168712 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 GGTACTCTGGCTGGAGGTGGTGG 75 0.00324364785628 3 1.63414074074 ..*...**............ 0 0 0.956169168712 Frock_VEGFA GGGTGGGGGGAGTTTGCTCCTGG 41 GGGTGAGGGGAATAAACTCCAGG 70 0.00324082760503 5 0.00178592956341 .....*.....*.***.... 2 2 0.837736878911 Frock_RAG1A GCCTCTTTCCCACCCACCTTGGG 33 ACCTCTTCCCTCCCCACCTTTGG 60 0.00313361449473 4 0.390673192771 *......*..**........ 1 1 1.0 Frock_VEGFA GGGTGGGGGGAGTTTGCTCCTGG 41 AGGTCGGGGGAGTTAGATCCCGG 70 0.00312142869326 4 0.163368333333 *...*.........*.*... 1 1 0.837736878911 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 CACCCACTACTCCCCGCCTCAGG 80 0.00301859454238 4 0.293524998117 *....*..*.*......... 1 1 0.978266119295 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 CAGTCCCCCCACCCCACCTCTGG 80 0.00301859454238 5 0.155289060241 *.**...*.......*.... 2 2 0.978266119295 Kim16_VEGFA1 GGGTGGGGGGAGTTTGCTCCAGG 41 GGGTGGGTGGAGTTTGCTACTGG 70 0.003 2 2.93382352941 .......*..........*. -1 -1 0.0849 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 AAGACCCCCCACCCCGCCCCAGG 80 0.00297834661515 5 0.298795443038 *.**...*..........*. 2 2 0.978266119295 Frock_VEGFA GGGTGGGGGGAGTTTGCTCCTGG 41 GGGGAGGGGGAGGGTGCTCCAGG 70 0.00295938731301 4 0.0824997740964 ...**.......**...... 1 1 0.837736878911 Frock_VEGFA GGGTGGGGGGAGTTTGCTCCTGG 41 GGGAGGGGAGAGTTTGTTCCAGG 70 0.00288263086974 3 0.699446791862 ...*....*.......*... 0 0 0.837736878911 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 CCGCCCCCCCACCCCGCCGCCGG 80 0.00285760283345 5 0.298795443038 ***....*..........*. 2 2 0.978266119295 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 GGAACTGTGGCTGGAGGTGGCAG 75 0.00278621033809 2 6.24466666667 ..*....*............ -1 -1 0.956169168712 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 GCCACAGCGGCCGGAGGTGGCAG 75 0.00274462510916 3 0.837857777778 .*...*.....*........ 0 0 0.956169168712 Wang_WAS-CR4 TGGATGGAGGAATGAGGAGTTGG 12 TCCATGGAGGAATGAGGAGAGGG 50 0.0027 3 1.47120112994 .**................* 0 0 0.2755 Frock_RAG1A GCCTCTTTCCCACCCACCTTGGG 33 ACCTCTTTCCATCCCACCTTGGG 60 0.0026859552812 3 0.768613333333 *.........**........ 0 0 1.0 Tsai_VEGFA_site3 GGTGAGTGAGTGTGTGCGTGTGG 6 GGTGGATGAGTGTGTGTGTGGGG 60 0.00266398812123 3 0.692578247261 ....**..........*... 0 0 0.893440475152 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 GCCACTGTGGCTGGAGGTGGGGA 75 0.00266145465131 2 6.69014084507 .*.....*............ -1 -1 0.956169168712 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 AACCACCCCCACCCCACCCCAGG 80 0.00261611527006 5 0.0521225316456 *...*..*.......*..*. 2 2 0.978266119295 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 CTCCCCCCCCTCCCCGCCTCGGG 80 0.00261611527006 4 0.794051204819 **.....*..*......... 1 1 0.978266119295 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 GTCACTCCCCACCCCGCCTCTGG 80 0.00261611527006 4 0.825790229885 .*.*.*.*............ 1 1 0.978266119295 Kim16_VEGFA1 GGGTGGGGGGAGTTTGCTCCAGG 41 AGCTGGAGGGAGTTTGCCCCAGG 70 0.0026 4 0.208990259333 *.*...*..........*.. 1 1 0.0849 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 GGCACGGAGGCTGGAAGTGGGGG 75 0.00257828419345 3 0.29290962963 .....*.*.......*.... 0 0 0.956169168712 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 GGCACTGGGGCAGGAGATGGGGG 75 0.00253669896453 3 0.506185654008 .......*...*....*... 0 0 0.956169168712 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 GTCCTCCACCACCCCGCCTCTGG 80 0.0025356194156 3 2.54350736278 .*..*..*............ 0 0 0.978266119295 Frock_VEGFA GGGTGGGGGGAGTTTGCTCCTGG 41 AAGTGGGAAGAGTTTGTTCCAGG 70 0.00252443413444 5 0.226302025316 **.....**.......*... 2 2 0.837736878911 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 GGCACTGAATCTGGAGGTGGGGG 75 0.0024951137356 3 1.30548095238 .......***.......... 0 0 0.956169168712 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 GTCACTGCGGCTGCAGATGGCGG 75 0.00245352850667 3 0.180752072968 .*...........*..*... 0 0 0.956169168712 Kim16_RNF2 GTCATCTTAGTCATTACCTGAGG 50 GGTATCTAAGTCATTACCTGTGG 40 0.0024 3 2.50789825971 .**....*............ 0 0 0.0033 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 GACCCCACCTACCCCACCTCAGG 80 0.00237462770667 4 0.154797629819 ......**.*.....*.... 1 1 0.978266119295 Tsai_HEK293_sgRNA2 GAACACAAAGCATAGACTGCGGG 39 AAACATAAAGCATAGACTGCAAA 45 0.00225606316977 2 3.83166666667 *....*.............. -1 -1 0.0580936266216 Frock_EMX GAGTCCGAGCAGAAGAAGAAGGG 22 ACGTCTGAGCAGAAGAAGAATGG 50 0.00224617396114 3 1.4680715198 **...*.............. 0 0 0.77161104313 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 GGCTCTTCGGCTGGAGGTAGCGG 75 0.00220401713311 3 0.677902985075 ...*..*...........*. 0 0 0.956169168712 Frock_VEGFA GGGTGGGGGGAGTTTGCTCCTGG 41 GGGAGGGGGCAGGTTGCTCCAGG 70 0.00220035137394 3 0.95247721519 ...*.....*..*....... 0 0 0.837736878911 Kim16_VEGFA3 GGTGAGTGAGTGTGTGCGTGTGG 6 TGTGTGAGTGAGTGTGTGTGTGG 60 0.0022 6 0.0567007279192 *...*.*.*.*.....*... 3 3 0.0056 Tsai_VEGFA_site3 GGTGAGTGAGTGTGTGCGTGTGG 6 TGTGAGTGAGTGTGTGCGTGTGA 60 0.00218359682068 1 100.0 *................... -2 -2 0.893440475152 Tsai_HEK293_sgRNA1 GGGAAAGACCCAGCATCCGTGGG 71 GAGAAAAGCCCAGCATCCTTAGG 60 0.00218272528843 4 0.34064625 .*....**..........*. 1 1 0.384159650764 Tsai_VEGFA_site1 GGGTGGGGGGAGTTTGCTCCTGG 41 GAGTGGGTGGAGTTTGCTACAGG 70 0.00216900135563 3 1.05555555556 .*.....*..........*. 0 0 0.757342973339 Cho_ccr5-2 GACACCGAAGCAGAGTTTTTAGG 50 CACACCGAAGCTGGGTTTTTAGG 45 0.00215 3 0.21797370892 *..........*.*...... 0 0 0.01731 Cho_ccr5-2 GACACCGAAGCAGAGTTTTTAGG 50 GACAACAAAGTAGAGTTTTTAGG 45 0.00213 3 0.964154618474 ....*.*...*......... 0 0 0.01731 Cho_ccr5-2 GACACCGAAGCAGAGTTTTTAGG 50 GAGACAGAAGGAGAGTTTTTAGG 45 0.00212 3 0.884726983122 ..*..*....*......... 0 0 0.01731 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 GCCCCCCACCACCCCACCCCCGG 80 0.00209289221605 4 0.085785 .*.....*.......*..*. 1 1 0.978266119295 Frock_VEGFA GGGTGGGGGGAGTTTGCTCCTGG 41 AGGTAGGAGAAGCTTGCTCCTGA 70 0.00208948095587 5 0.326366891566 *...*..*.*..*....... 2 2 0.837736878911 Frock_VEGFA GGGTGGGGGGAGTTTGCTCCTGG 41 GGTGGGGGAGAGCTAGCTCCGGG 70 0.00205536698108 5 0.0572136143318 ..**....*...*.*..... 2 2 0.837736878911 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 GGTACAGCGGCTGGGGGAGGCGG 75 0.00203767621741 4 0.0496130024133 ..*..*........*..*.. 1 1 0.956169168712 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 TGGACTGCGGCTGGAGAGGGAGG 75 0.00203767621741 4 0.117805636667 *.*.............**.. 1 1 0.956169168712 Kim16_HEK4 GGCACTGCGGCTGGAGGTGGGGG 14 GGAACTGGGGCTGGGGGTGGGGG 75 0.002 3 0.785713928013 ..*....*......*..... 0 0 0.002 Tsai_VEGFA_site3 GGTGAGTGAGTGTGTGCGTGTGG 6 CATGAGTGAGTGTGTGGGTGGGG 60 0.00196523713861 3 1.29012345679 **..............*... 0 0 0.893440475152 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 GGCACCGCGGCCGGAGCTGTGGG 75 0.00195450575955 4 0.0718329643434 .....*.....*....*..* 1 1 0.956169168712 Frock_EMX GAGTCCGAGCAGAAGAAGAAGGG 22 AAGTCCGAGGAGAGGAAGAAAGG 50 0.0019109241162 3 0.408036150235 *........*...*...... 0 0 0.77161104313 Tsai_HEK293_sgRNA1 GGGAAAGACCCAGCATCCGTGGG 71 GGAAAAGACCAAGCATCAGTGGG 60 0.00187090739008 3 0.337957631841 ..*.......*......*.. 0 0 0.384159650764 Frock_RAG1A GCCTCTTTCCCACCCACCTTGGG 33 GTGTATTCCCCACCCACCTTGGG 60 0.00181419786537 4 1.34583333333 .**.*..*............ 1 1 1.0 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 GGGCCCTCCCACCTCGCCCCTGG 80 0.00181115672543 6 0.0200986759729 .**...**.....*....*. 3 3 0.978266119295 Frock_EMX GAGTCCGAGCAGAAGAAGAAGGG 22 GAGTAGGAGCAGGAGAAGAAGGA 50 0.00181034916271 3 0.62567721519 ....**......*....... 0 0 0.77161104313 Kim16_VEGFA3 GGTGAGTGAGTGTGTGCGTGTGG 6 TGTGAGTGAGTGAGTGAATGTGG 60 0.0018 4 0.046238115 *...........*...**.. 1 1 0.0056 Tsai_VEGFA_site3 GGTGAGTGAGTGTGTGCGTGTGG 6 AGTGAGTATGTGTGTGTGTGGGG 60 0.00179054939296 4 0.372455416667 *......**.......*... 1 1 0.893440475152 Hsu_EMX1.2 GACATCGATGTCCTCCCCATTGG 67 CACATAGGTGTCCTCCCCATAGG 55 0.00178971 3 1.53882195448 *....*.*............ 0 0 0.002124957 Frock_RAG1A GCCTCTTTCCCACCCACCTTGGG 33 GCCCCTTCCCCACCCACCCTGTG 60 0.00174351483166 3 0.992537313433 ...*...*..........*. 0 0 1.0 Hsu_EMX1.3 GAGTCCGAGCAGAAGAAGAAGGG 22 ACGTCTGAGCAGAAGAAGAATGG 50 0.001718713 3 1.4680715198 **...*.............. 0 0 0.291483904 Cho_ccr5-2 GACACCGAAGCAGAGTTTTTAGG 50 GACACCGAAGCAGGGTTTTCAGG 45 0.00169 2 0.415678521127 .............*.....* -1 -1 0.01731 Kim/K562_VEGFA GGGTGGGGGGAGTTTGCTCCTGG 41 GGGTGGGGGGAGTTTGCCCCAGG 70 0.00168 1 19.6 .................*.. -2 -2 0.032 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 GGCACAGCAGGTGGAGGTGGAGG 75 0.00166340915707 3 0.49783039272 .....*..*.*......... 0 0 0.956169168712 Cho_c4bpb AATGACCACTACATCCTCAAGGG 47 AATGACCACAGCATCCTCAGTGG 40 0.00166 3 0.59998238 .........**........* 0 0 0.00301 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 AGCACTGTAGCAAGAGGTGGAGG 75 0.00162182392814 5 0.10652530294 *......**..**....... 2 2 0.956169168712 Tsai_VEGFA_site3 GGTGAGTGAGTGTGTGCGTGTGG 6 GATGAGTGAGTGAGTGAGTGGGG 60 0.00161586164731 3 0.469470149254 .*..........*...*... 0 0 0.893440475152 Tsai_VEGFA_site3 GGTGAGTGAGTGTGTGCGTGTGG 6 TGTGAGTGAGTGTGTGTGTGTGA 60 0.00161586164731 2 5.89919354839 *...............*... -1 -1 0.893440475152 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 CTCACCCCCCACCCCACCTCTGG 80 0.00160991708927 5 0.157493975904 **.*...*.......*.... 2 2 0.978266119295 Kim/K562_VEGFA GGGTGGGGGGAGTTTGCTCCTGG 41 TAGTGGAGGGAGCTTGCTCCTGG 70 0.0016 4 0.397317958861 **....*.....*....... 1 1 0.032 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 GGCACTGAGACCAGAGGTGGTGG 75 0.00158023869921 4 0.228837884341 .......*.*.**....... 1 1 0.956169168712 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 GACACTGCAGCTGGAGGTGGGGT 75 0.00153865347029 2 4.33171641791 .*......*........... -1 -1 0.956169168712 Frock_VEGFA GGGTGGGGGGAGTTTGCTCCTGG 41 AAGTGGGAGGAGACTGCTCCAGG 70 0.00153512886554 5 0.0527998554217 **.....*....**...... 2 2 0.837736878911 Tsai_VEGFA_site3 GGTGAGTGAGTGTGTGCGTGTGG 6 GGAGAGTGAGTGTGTGTGTGAGA 60 0.00152851777448 2 4.62345512821 ..*.............*... -1 -1 0.893440475152 Kim/Hap1_VEGFA GGGTGGGGGGAGTTTGCTCCTGG 41 GGGGAGGGGAAGTTTGCTCCTGG 70 0.00151 3 2.34257028112 ...**....*.......... 0 0 0.06442 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 GACACAACGGCAGGAGGTGGCGG 75 0.00149706824136 4 0.290868510542 .*...**....*........ 1 1 0.956169168712 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 ATGCCCCACCCCCCCGCCCCCGG 80 0.00148917330757 6 0.109610828313 ***....*..*.......*. 3 3 0.978266119295 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 GTCCCCCTCCTCCCCACCTCCGG 80 0.00148917330757 3 0.300786069652 .*........*....*.... 0 0 0.978266119295 Hsu_EMX1.3 GAGTCCGAGCAGAAGAAGAAGGG 22 GAGTCCAAGCAGTAGAGGAAGGG 50 0.001466994 3 0.286445646667 ......*.....*...*... 0 0 0.291483904 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 GTCCCTCCCCACCCCGCCTTGGG 80 0.00144892538034 4 0.421955545775 .*...*.*...........* 1 1 0.978266119295 Tsai_VEGFA_site1 GGGTGGGGGGAGTTTGCTCCTGG 41 AGGTGGTGGGAGCTTGTTCCTGG 70 0.00144600090375 4 0.16112567625 *.....*.....*...*... 1 1 0.757342973339 Tsai_VEGFA_site3 GGTGAGTGAGTGTGTGCGTGTGG 6 GGTGAGTAAGTGTGAGCGTAAGG 60 0.00144117390165 3 0.332294835681 .......*......*....* 0 0 0.893440475152 Tsai_VEGFA_site3 GGTGAGTGAGTGTGTGCGTGTGG 6 GGTGAGTGTGTGTGTGCATGTGG 60 0.00144117390165 2 0.964137288136 ........*........*.. -1 -1 0.893440475152 Frock_RAG1A GCCTCTTTCCCACCCACCTTGGG 33 ACCTTGTCCCCACCCACCAGGGG 60 0.00143722168555 6 0.0505329894578 *...**.*..........** 3 3 1.0 Frock_RAG1A GCCTCTTTCCCACCCACCTTGGG 33 GCCCCTTACCCATCCACCCTGGG 60 0.00141366067432 4 0.19301625 ...*...*....*.....*. 1 1 1.0 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 AACACCCTCCACCCCACCACAGG 80 0.00140867745311 4 0.0906179577465 *..*...........*..*. 1 1 0.978266119295 Tsai_VEGFA_site3 GGTGAGTGAGTGTGTGCGTGTGG 6 AGTGAGTGAGTGAGTGAGTGGGG 60 0.00139750196524 3 0.499277777778 *...........*...*... 0 0 0.893440475152 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 CAGACTGCGGCAGGGGGTGGCGG 75 0.00137231255458 5 0.119045315855 ***........*..*..... 2 2 0.956169168712 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 GGCGCTGCGGCTGGAGCCGGCGG 75 0.00137231255458 3 0.237767827529 ...*............**.. 0 0 0.956169168712 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 GCCGCCCCCCACTCCGCCTCCGG 80 0.00136842952588 4 0.553689759036 .*.*...*....*....... 1 1 0.978266119295 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 GACACAGTGGCTGGAGGTGTGGG 75 0.00133072732565 4 0.421955545775 .*...*.*...........* 1 1 0.956169168712 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 GTAACTGCGGCTGGCGGTGGTGG 75 0.00133072732565 3 0.785713928013 .**...........*..... 0 0 0.956169168712 Kim16_EMX1 GAGTCCGAGCAGAAGAAGAAGGG 22 GAATCCAAGCAGAAGAAGAGAAG 50 0.0013 3 0.941031617989 ..*...*............* 0 0 0.0068 Frock_VEGFA GGGTGGGGGGAGTTTGCTCCTGG 41 AAATGGGGGGAGTTTGCCCCCCG 70 0.00129633104201 4 0.305988666667 ***..............*.. 1 1 0.837736878911 Frock_VEGFA GGGTGGGGGGAGTTTGCTCCTGG 41 GGGGGCGGGGAGGTTGCCCCGGG 70 0.00129633104201 4 0.0689809129747 ...*.*......*....*.. 1 1 0.837736878911 Frock_RAG1A GCCTCTTTCCCACCCACCTTGGG 33 GCCCCTGCCCCACCCACCTGTGG 60 0.00129585561812 4 0.45095075 ...*..**...........* 1 1 1.0 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 GGCACTCTGGCTGGAGCTGGGGG 75 0.00128914209673 3 0.74016962963 ......**........*... 0 0 0.956169168712 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 CTACCCCCACTCCCCGCCTCCGG 80 0.00128793367142 6 0.202835027778 ***....**.*......... 3 3 0.978266119295 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 TTCTCCCTCCTCCCCGCCTCGGG 80 0.00128793367142 4 0.794051204819 **.*......*......... 1 1 0.978266119295 Tsai_VEGFA_site3 GGTGAGTGAGTGTGTGCGTGTGG 6 GATGAGTGTGTGTGTGTGTGAGG 60 0.001266486156 3 0.741204809287 .*......*.......*... 0 0 0.893440475152 Tsai_VEGFA_site1 GGGTGGGGGGAGTTTGCTCCTGG 41 GGGCAAGGGGAGGTTGCTCCTGG 70 0.00126525079078 4 0.334982304217 ...***......*....... 1 1 0.757342973339 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 AAGCCCCCCCACCCCGCCCCGGG 80 0.00124768574418 4 0.519472711268 *.*....*..........*. 1 1 0.978266119295 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 CCGCCCCTCCACCCCGCCACTGG 80 0.00124768574418 4 0.519472711268 ***...............*. 1 1 0.978266119295 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 GGCCCTGGGGCTGGAGGTGTTGG 75 0.0012475568678 3 1.39735449735 ...*...*...........* 0 0 0.956169168712 Tsai_HEK293_sgRNA1 GGGAAAGACCCAGCATCCGTGGG 71 ATGAAAGACCCAGCATCCATTGA 60 0.00124727159339 3 1.12711864407 **................*. 0 0 0.384159650764 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 TATCCTCCCCACCCCGCCCCGGG 80 0.00120743781695 5 0.180771243038 *.*..*.*..........*. 2 2 0.978266119295 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 AGCACTGGGGATGGAGGTGTAGG 75 0.00120597163887 4 0.38708318662 *......*..*........* 1 1 0.956169168712 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 ACTCCCCTCCACCCCGGCTCGGG 80 0.00116718988972 4 0.601049166667 ***.............*... 1 1 0.978266119295 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 ATCCCTCTCCACCCCACCCCAGG 80 0.00116718988972 5 0.0315341316456 **...*.........*..*. 2 2 0.978266119295 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 TGCACCCCCCACCCCGCCCCTGG 80 0.00116718988972 5 0.303037974684 **.*...*..........*. 2 2 0.978266119295 Cho_ccr5-7 AACACCAGTGAGTAGAGCGGAGG 48 TACTCCAGTGAGTAGAGAGGCGG 55 0.00116 3 0.656790123457 *..*.............*.. 0 0 0.42888 Tsai_VEGFA_site3 GGTGAGTGAGTGTGTGCGTGTGG 6 GGTGAATGAGTGTGTGCTCTGGG 60 0.00113547034676 4 0.0234134052294 .....*...........*** 1 1 0.893440475152 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 AACACTGTGGCCGGGGGTGGTGG 75 0.00112280118102 5 0.120735614458 **.....*...*..*..... 2 2 0.956169168712 Kim16_HEK3 GGCCCAGACTGAGCACGTGATGG 60 GGCTCAGACTGAGCACCTGAGAG 65 0.0011 2 4.25290697674 ...*............*... -1 -1 0.0013 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 TGCCCCCTCT-CCCCGCCCCCGG 80 0.00108669403526 5 0.154899375949 **.......**.......*. 2 2 0.978266119295 Tsai_VEGFA_site3 GGTGAGTGAGTGTGTGCGTGTGG 6 AGGGAGTGACTGTGTGCGTGTGG 60 0.00104812647393 3 2.42672489451 *.*......*.......... 0 0 0.893440475152 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 GGCAGGGCGGCTGGAGGAGGTGG 75 0.00103963072317 3 0.352585289515 ....**...........*.. 0 0 0.956169168712 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 AACCCCACCCACCCCATCTCAGG 80 0.00100619818079 5 0.0435107311392 *.....**.......**... 2 2 0.978266119295 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 AGCCAACCCCACCCCGCCTCTGG 80 0.00100619818079 5 0.505274725275 **..**.*............ 2 2 0.978266119295 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 AGCCCCCACCTCCCCGCCTCGGG 80 0.00100619818079 4 0.794051204819 **.....*..*......... 1 1 0.978266119295 Cho_ccr5-2 GACACCGAAGCAGAGTTTTTAGG 50 GACACTGAAGCAGTGATTTTAGG 45 0.001 3 0.0436435348148 .....*.......*.*.... 0 0 0.01731 Ran_EMX1-sg1 GCCTCCCCAAAGCCTGGCCAGGG 23 TTCTCCCCAAAGCCTGGCCACAG 70 0.001 2 5.21978021978 **.................. -1 -1 0.2904 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 GGCACTGCAGACGGAGGTGTGGG 75 0.00099804549424 4 0.0995384507666 ........*.**.......* 1 1 0.956169168712 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 GGGGCTGCGGCCGGAGGTGGTGG 75 0.00099804549424 3 1.29636118143 ..**.......*........ 0 0 0.956169168712 Tsai_VEGFA_site1 GGGTGGGGGGAGTTTGCTCCTGG 41 GGTGGGGGAGAGCTAGCTCCGGG 70 0.000994125621329 5 0.0572136143318 ..**....*...*.*..... 2 2 0.757342973339 Ran_EMX1-sg2 GGCCAGGCTTTGGGGAGGCCTGG 15 AGGTGGGCTTTGGGGAGGCCGGG 75 0.00098 4 1.28667582418 *.***............... 1 1 0.00142 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 TCCCACCCCCACCCCGCCACGGG 80 0.000965950253562 5 0.303037974684 **..*..*..........*. 2 2 0.978266119295 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 TCCCCACCCCGCCCCGCCTCTGG 80 0.000965950253562 5 0.293320689655 **...*.*..*......... 2 2 0.978266119295 Tsai_VEGFA_site3 GGTGAGTGAGTGTGTGCGTGTGG 6 AGTGAGTGAGTGTGTGTGTGAGA 60 0.000960782601101 2 5.89919354839 *...............*... -1 -1 0.893440475152 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 TACACTGCGGCCGGGAGTGGTGG 75 0.000956460265314 5 0.0207665256867 **.........*..**.... 2 2 0.956169168712 Cho_ccr5-2 GACACCGAAGCAGAGTTTTTAGG 50 GATACTGAAGCAGAGATTTTGGG 45 0.00095 3 0.305079818466 ..*..*.........*.... 0 0 0.01731 Tsai_HEK293_sgRNA1 GGGAAAGACCCAGCATCCGTGGG 71 GGGAAGGACCCAGCATTCCTGGG 60 0.000935453695042 3 0.218162147887 .....*..........*.*. 0 0 0.384159650764 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 ACACCCCCCCACCCCACCCCAGG 80 0.00092570232633 6 0.0339694819277 ***....*.......*..*. 3 3 0.978266119295 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 GACCCCTACCACCCCATCTCAGG 80 0.00092570232633 4 0.0647091069277 ......**.......**... 1 1 0.978266119295 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 GCCACCGCGGCAGGAGGCGGAGG 75 0.000914875036387 4 0.09237382 .*...*.....*.....*.. 1 1 0.956169168712 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 GGCACTGGGGCTGGGGGTGCAGG 75 0.000914875036387 3 0.332294835681 .......*......*....* 0 0 0.956169168712 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 GGCACTGTGGCAAGAGGTGGGAG 75 0.000914875036387 3 0.462027586207 .......*...**....... 0 0 0.956169168712 Cho_ccr5-4 AAATGAGAAGAAGAGGCACAGGG 10 AAATGTGAAGAAAAGGCACAGGG 40 0.0009 2 1.65991231343 .....*......*....... -1 -1 0.02015 Kim16_HEK1 GGGAAAGACCCAGCATCCGTGGG 71 TTATAAGACCCAGCATCCGTAAG 60 0.0009 4 1.28667582418 ****................ 1 1 0.0009 Kim16_RNF2 GTCATCTTAGTCATTACCTGAGG 50 AATATGTTAGTCATTACCTGAGG 40 0.0009 4 0.778438873626 ***..*.............. 1 1 0.0033 Kim16_VEGFA3 GGTGAGTGAGTGTGTGCGTGTGG 6 GGTGTGTGAGTGTGTGCATTGGG 60 0.0009 3 0.257530348259 ....*............*.* 0 0 0.0056 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 CCGCCCCCCCACCCCAACTCCGG 80 0.000885454399098 6 0.0415182556894 ***....*.......**... 3 3 0.978266119295 Tsai_VEGFA_site3 GGTGAGTGAGTGTGTGCGTGTGG 6 GGTGAGCAAGTGTGTGTGTGTGG 60 0.000873438728273 3 0.74016962963 ......**........*... 0 0 0.893440475152 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 GGCACTGCGGGAGGAGGTGGGCG 75 0.00087328980746 2 1.42531318681 ..........**........ -1 -1 0.956169168712 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 AACCTCCCCCACCCCACCCCAGG 80 0.000845206471867 5 0.0521225316456 *...*..*.......*..*. 2 2 0.978266119295 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 GTCCCCTCCCACCCCGCCTCCAG 80 0.000845206471867 3 1.73721552878 .*....**............ 0 0 0.978266119295 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 GGCGCAGCGGCTGGAGGAGGTGC 75 0.000831704578534 3 0.373635157546 ...*.*...........*.. 0 0 0.956169168712 Tsai_VEGFA_site3 GGTGAGTGAGTGTGTGCGTGTGG 6 CGTGAGTGAGTGTGTACCTGGGG 60 0.00082976679186 3 0.112967901235 *..............*.*.. 0 0 0.893440475152 Kim16_EMX1 GAGTCCGAGCAGAAGAAGAAGGG 22 GAGCCTGAGCAGAAGGAGAAGGG 50 0.0008 3 0.309411580595 ...*.*.........*.... 0 0 0.0068 Ran_EMX1-sg1 GCCTCCCCAAAGCCTGGCCAGGG 23 TTCTCTCCAAAGCCTGGCCAGAG 70 0.0008 3 1.4680715198 **...*.............. 0 0 0.2904 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 GGCCCTGCGGCTGGAGATATGGG 75 0.000790119349607 4 0.08007181875 ...*............*.** 1 1 0.956169168712 Tsai_VEGFA_site3 GGTGAGTGAGTGTGTGCGTGTGG 6 GGTGGATGACTGTGTGTGTGGGG 60 0.000786094855446 4 0.32246476068 ....**...*......*... 1 1 0.893440475152 Cho_ccr5-6 ATGAACACCAGTGAGTAGAGCGG 34 AAGAACACAAGAGAGTAGAGAGG 45 0.00078 3 0.846167111111 .*......*..*........ 0 0 0.29692 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 CACCCCCTCCCCTCCGCCTCAGG 80 0.000764710617403 3 0.63864084507 *.........*.*....... 0 0 0.978266119295 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 TGGCCCCTCCGCCCCACCTCTGG 80 0.000764710617403 5 0.0861854284337 ***.......*....*.... 2 2 0.978266119295 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 AGCACAGCGGCTGGAGAAGGCAG 75 0.00074853412068 4 0.0722843916667 *....*..........**.. 1 1 0.956169168712 Tsai_VEGFA_site3 GGTGAGTGAGTGTGTGCGTGTGG 6 AGTGAGTAAGTGAGTGAGTGAGG 60 0.000742422919032 4 0.23590875 *......*....*...*... 1 1 0.893440475152 Tsai_VEGFA_site3 GGTGAGTGAGTGTGTGCGTGTGG 6 GGTGTATGAGTGTGTGTGTGAGG 60 0.000742422919032 3 0.692578247261 ....**..........*... 0 0 0.893440475152 Tsai_VEGFA_site3 GGTGAGTGAGTGTGTGCGTGTGG 6 TGTGAGTGAGTATGTACATGTGG 60 0.000742422919032 4 0.026261648 *..........*...*.*.. 1 1 0.893440475152 Tsai_VEGFA_site3 GGTGAGTGAGTGTGTGCGTGTGG 6 TGTGGGTGAGTGTGTGTGTGTGG 60 0.000742422919032 3 1.29012345679 *...*...........*... 0 0 0.893440475152 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 AGACCCCCCCACCCCACCCCAGG 80 0.000724462690171 6 0.0339694819277 ***....*.......*..*. 3 3 0.978266119295 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 CCCCCCTCCCACCCCGCCTCTAG 80 0.000724462690171 4 0.932255747126 **....**............ 1 1 0.978266119295 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 CTACCCCTCCACCCCGACTCGGA 80 0.000724462690171 4 0.601049166667 ***.............*... 1 1 0.978266119295 Cho_ccr5-6 ATGAACACCAGTGAGTAGAGCGG 34 AAGAACAGCAGTGAATAGAGAGG 45 0.00072 3 0.796870109546 .*.....*......*..... 0 0 0.29692 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 AGCACTGCGCTTGGGGGTGGGGG 75 0.000706948891754 4 0.205917821203 *........**...*..... 1 1 0.956169168712 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 GGCACTGCAGCAGGGGATGGGGG 75 0.000706948891754 4 0.0423366219138 ........*..*..*.*... 1 1 0.956169168712 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 TGCACTGCAGCTGCAGGTGGAGG 75 0.000706948891754 3 0.270694992175 *.......*....*...... 0 0 0.956169168712 Tsai_HEK293_sgRNA3 GGCCCAGACTGAGCACGTGATGG 60 GAGCCAGAATGAGCACGTGAGGG 65 0.000700525394046 3 1.53232583668 .**.....*........... 0 0 0.273555166374 Kim16_FANCF GGAATCCCTTCTGCAGCACCTGG 41 GGAACACCTTCTGCAGCTCCAGG 60 0.0007 3 0.352585289515 ....**...........*.. 0 0 0.0007 Kim16_VEGFA3 GGTGAGTGAGTGTGTGCGTGTGG 6 GATGTGTGAGTGTGTGCCTGTGG 60 0.0007 3 0.656790123457 .*..*............*.. 0 0 0.0056 Tsai_VEGFA_site3 GGTGAGTGAGTGTGTGCGTGTGG 6 TGTGAGTGGGTGTGTGTGTGGGG 60 0.000698750982619 3 0.788265432099 *.......*.......*... 0 0 0.893440475152 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 ACGCCCCCCCACCCCACGTCTGG 80 0.00068421476294 6 0.0211365665328 ***....*.......*.*.. 3 3 0.978266119295 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 CACACCCACCACCCCGCCTCAGA 80 0.00068421476294 3 2.54350736278 *..*...*............ 0 0 0.978266119295 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 GGCCCACTCCACTCCGTCTCCGG 80 0.00068421476294 4 0.14272479375 .*...*......*...*... 1 1 0.978266119295 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 GGAACGGCGGCCGGAGGTGTAGG 75 0.000665363662827 4 0.19377859479 ..*..*.....*.......* 1 1 0.956169168712 Cho_ccr-1 GAATCCTAAAAACTCTGCTTCGG 35 GAATCCTGAAAACCCTGCTTCGG 35 0.00065 2 0.996830985915 .......*.....*...... -1 -1 0.00219 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 CACCCCCCGCACCCCGCCCCAGG 80 0.000643966835708 4 0.321904489437 *......**.........*. 1 1 0.978266119295 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 CGCCCACCCCACCCCACCTCAGG 80 0.000643966835708 5 0.0952838554217 **...*.*.......*.... 2 2 0.978266119295 Tsai_EMX1 GAGTCCGAGCAGAAGAAGAAGGG 22 GAGTAGGAGCAGGAGAAGAAGGA 50 0.000634920634921 3 0.62567721519 ....**......*....... 0 0 0.589931972789 Tsai_VEGFA_site1 GGGTGGGGGGAGTTTGCTCCTGG 41 AGGAAGGAGGAGTTAGCTCCTGG 70 0.000632625395391 5 0.245397590361 *..**..*......*..... 2 2 0.757342973339 Hsu_EMX1.3 GAGTCCGAGCAGAAGAAGAAGGG 22 AAGTCTGAGCAGAAGAAGCACAG 50 0.000625807 3 0.681906779661 *....*............*. 0 0 0.291483904 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 AACCTCCACCTCCCCGCCTCAGG 80 0.000603718908476 4 0.794051204819 *...*..*..*......... 1 1 0.978266119295 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 CCACCATCCCACCCCGCCTCTGG 80 0.000603718908476 6 0.23629944475 ***..***............ 3 3 0.978266119295 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 CCCCACCCCCACCCCGCCCCCGG 80 0.000603718908476 5 0.303037974684 **..*..*..........*. 2 2 0.978266119295 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 GACACACCCCCCCCCGCCTCCGG 80 0.000603718908476 4 0.458313577586 ...*.*.*..*......... 1 1 0.978266119295 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 GCCACCCCCCACCCCACCCCAGG 80 0.000603718908476 5 0.0521225316456 .*.*...*.......*..*. 2 2 0.978266119295 Ran_EMX1-sg1 GCCTCCCCAAAGCCTGGCCAGGG 23 TCCTTCCCAAAGCCTGGCCAGGG 70 0.0006 2 6.01265822785 *...*............... -1 -1 0.2904 Cho_c4bpb AATGACCACTACATCCTCAAGGG 47 AATGACCACTACACCCAGAAAGG 40 0.00058 3 0.0272831749681 .............*..**.. 0 0 0.00301 Hsu_EMX1.1 GTCACCTCCAATGACTAGGGTGG 68 TTCACCTCCAAAAACTAGGGAAG 55 0.00057238 3 0.566146478873 *..........**....... 0 0 0.030092945 Tsai_VEGFA_site3 GGTGAGTGAGTGTGTGCGTGTGG 6 AATGAGTGAGTGTGTGTGTGTGA 60 0.000567735173378 3 1.29012345679 **..............*... 0 0 0.893440475152 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 AGGCCCTCCCACCCCGCATCAGG 80 0.000563470981244 6 0.0839318310576 ***...**.........*.. 3 3 0.978266119295 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 CACCTCCACAACTCCGCCTCTGG 80 0.000563470981244 5 0.326366891566 *...*..*.*..*....... 2 2 0.978266119295 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 TCTCCCCTCCACCCCGCCCTCGG 80 0.000563470981244 5 0.124597699747 ***...............** 2 2 0.978266119295 Tsai_EMX1 GAGTCCGAGCAGAAGAAGAAGGG 22 AAGTCCCGGCAGAGGAAGAAGGG 50 0.000544217687075 4 0.152972547468 *.....**.....*...... 1 1 0.589931972789 Tsai_VEGFA_site1 GGGTGGGGGGAGTTTGCTCCTGG 41 GGTTGAGGGGAGTCTGCTCCAGG 70 0.000542250338906 3 0.250189100741 ..*..*.......*...... 0 0 0.757342973339 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 GACACTAGGGCAGGAGGTGGAGG 75 0.000540607976047 4 0.48077439759 .*....**...*........ 1 1 0.956169168712 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 GGCACTGAGAAAGGAGGTGGAGG 75 0.000540607976047 4 0.328178361264 .......*.***........ 1 1 0.956169168712 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 GGCACTGGGGCTGGAGACGGGGG 75 0.000540607976047 3 0.212405925926 .......*........**.. 0 0 0.956169168712 Cho_ccr5-6 ATGAACACCAGTGAGTAGAGCGG 34 AGAAACACTAGTGAGTAGAGGGG 45 0.00054 3 1.53232583668 .**.....*........... 0 0 0.29692 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 ACTCCCCTCCACCCCACCTCTGA 80 0.000523223054013 4 0.268520666667 ***............*.... 1 1 0.978266119295 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 CACCCCCCCCCCCCCGCCCCCGG 80 0.000523223054013 4 0.29240096831 *......*..*.......*. 1 1 0.978266119295 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 TACTCCCCCCACCCAGCCTCAGG 80 0.000523223054013 4 0.402848101266 *..*...*......*..... 1 1 0.978266119295 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 TCCCCCCTCCACCCCCGCCCCCG 80 0.000523223054013 5 0.0200671746835 **.............**.*. 2 2 0.978266119295 Tsai_FANCF GGAATCCCTTCTGCAGCACCTGG 41 GGAGTCCCTCCTGCAGCACCTGA 60 0.00050163029847 2 6.16161971831 ...*.....*.......... -1 -1 0.396037120642 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 CCCACTGTGGCTGGAGGTGTGGG 75 0.00049902274712 4 0.697447183099 **.....*...........* 1 1 0.956169168712 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 GACACTGTGGCTGGAAGTGGAAG 75 0.00049902274712 3 0.541956882255 .*.....*.......*.... 0 0 0.956169168712 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 GGCACAGGGGCTGAAGGTGATGG 75 0.00049902274712 4 0.0565046546677 .....*.*.....*.....* 1 1 0.956169168712 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 GGCACTACAGCTGGAGGTGGCAA 75 0.00049902274712 2 2.27843304598 ......*.*........... -1 -1 0.956169168712 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 GGCACTGGGTCTGAAGGTGGAGG 75 0.00049902274712 3 0.349042971888 .......*.*...*...... 0 0 0.956169168712 Cho_ccr5-8 CCAGTGAGTAGAGCGGAGGCAGG 37 CCAGTGAGTAGGGCTGGGGCAGG 65 0.00049 3 0.123183478927 ...........*..*.*... 0 0 0.02848 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 AACACCCCCCACCCCACCCCGGG 80 0.000482975126781 5 0.0521225316456 *..*...*.......*..*. 2 2 0.978266119295 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 AGCCGCCCCCACCCCGCCCCCGG 80 0.000482975126781 5 0.303037974684 **..*..*..........*. 2 2 0.978266119295 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 GCCTCCCCCCACCCAGCCTCGGG 80 0.000482975126781 4 0.402848101266 .*.*...*......*..... 1 1 0.978266119295 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 TCCCCCCACCACCCCACCCCCGG 80 0.000482975126781 5 0.0521225316456 **.....*.......*..*. 2 2 0.978266119295 Tsai_VEGFA_site3 GGTGAGTGAGTGTGTGCGTGTGG 6 GGTGAGAGAGTGTGTGCGTAGGA 60 0.00048039130055 2 3.14616802326 ......*............* -1 -1 0.893440475152 Tsai_VEGFA_site3 GGTGAGTGAGTGTGTGCGTGTGG 6 TGTGAGTGAGTGTGTGTGTGTGA 60 0.00048039130055 2 5.89919354839 *...............*... -1 -1 0.893440475152 Cho_ccr5-3 GGTCCTGCCGCTGCTTGTCATGG 50 GTTCCTGCTGCTGCTTCTCAAGG 65 0.00048 3 0.741204809287 .*......*.......*... 0 0 0.00125 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 TGCTCTGCGGCAGGAGGAGGAGG 75 0.000457437518194 4 0.152684 *..*.......*.....*.. 1 1 0.956169168712 Tsai_EMX1 GAGTCCGAGCAGAAGAAGAAGGG 22 TCATCCAAGCAGAAGAAGAAGAG 50 0.000453514739229 4 0.919204166667 ***...*............. 1 1 0.589931972789 Tsai_VEGFA_site1 GGGTGGGGGGAGTTTGCTCCTGG 41 AAGTAAGGGAAGTTTGCTCCTGG 70 0.000451875282422 5 0.486753793103 **..**...*.......... 2 2 0.757342973339 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 AAGACTGGGGCTGGAGGTGGGGG 75 0.000415852289267 4 1.34583333333 ***....*............ 1 1 0.956169168712 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 AGCACAGAGGCTGGAGGTGGGGT 75 0.000415852289267 3 1.53882195448 *....*.*............ 0 0 0.956169168712 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 GACACTAAGGCTGGAGGTGGGGA 75 0.000415852289267 3 1.73721552878 .*....**............ 0 0 0.956169168712 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 GGCACTGCGGCCAGAGGGAGCGG 75 0.000415852289267 4 0.0160456405345 ...........**....**. 1 1 0.956169168712 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 GGCAGTCCGGATGGAGGTGGGGG 75 0.000415852289267 3 0.964154618474 ....*.*...*......... 0 0 0.956169168712 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 CCCCCACCCCACCCCGCCTCCAG 80 0.000402479272317 4 0.825790229885 **...*.*............ 1 1 0.978266119295 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 CCGCCCCTGCACCCAGCCTCCGG 80 0.000402479272317 5 0.147838796723 ***.....*.....*..... 2 2 0.978266119295 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 GGCCCCACCCACCCCGCCTTCTG 80 0.000402479272317 4 0.476356426056 .*....**...........* 1 1 0.978266119295 Kim16_HEK2 GAACACAAAGCATAGACTGCGGG 39 AAGAACAAAACATAGACTGCAGG 45 0.0004 4 1.29924804217 *.**.....*.......... 1 1 0.0004 Ran_EMX1-sg1 GCCTCCCCAAAGCCTGGCCAGGG 23 GACCCCTCAAAGCCTGGCCAGAG 70 0.0004 3 1.65734355045 .*.*..*............. 0 0 0.2904 Wang_WAS-CR4 TGGATGGAGGAATGAGGAGTTGG 12 TAGATGAAGGAATGAGGAGAAGG 50 0.0004 3 1.01909774011 .*....*............* 0 0 0.2755 Wang_WAS-CR4 TGGATGGAGGAATGAGGAGTTGG 12 TCTCAGGAGGAATGAGGAGTTGG 50 0.0004 4 1.28667582418 .****............... 1 1 0.2755 Tsai_VEGFA_site3 GGTGAGTGAGTGTGTGCGTGTGG 6 AGTGAGAAAGTGTGTGCATGCGG 60 0.000393047427723 4 0.211957666667 *.....**.........*.. 1 1 0.893440475152 Cho_c4bpb AATGACCACTACATCCTCAAGGG 47 ATTAACCACTACATTCTCAAAGG 40 0.00038 3 0.796870109546 .*.*..........*..... 0 0 0.00301 Hsu_EMX1.3 GAGTCCGAGCAGAAGAAGAAGGG 22 GAGTCCCAGAAGAAGAAAAAAAG 50 0.000379055 3 0.347045352889 ......*..*.......*.. 0 0 0.291483904 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 GGCAGTGCGGCTGGAGCTGCGGG 75 0.00037426706034 3 0.50586318408 ....*...........*..* 0 0 0.956169168712 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 ACCCCACCCCACCCCGTCTCCGG 80 0.000362231345086 5 0.224079746835 **...*.*........*... 2 2 0.978266119295 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 AGTCCCATCCACCCCGCCTAAGG 80 0.000362231345086 5 0.270159456911 ***...*............* 2 2 0.978266119295 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 CACCCCGCCCACCCCGCCCCTGG 80 0.000362231345086 4 0.359837588028 *.....**..........*. 1 1 0.978266119295 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 CCCCCTCCCCACCCCGCCGCAGG 80 0.000362231345086 5 0.183337974684 **...*.*..........*. 2 2 0.978266119295 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 CCGCCCCCCCATCCCGCCCCAGG 80 0.000362231345086 6 0.0971685180723 ***....*...*......*. 3 3 0.978266119295 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 CGTCCCCCCCCCCCCGCCTCAGG 80 0.000362231345086 5 0.47804 ***....*..*......... 2 2 0.978266119295 Tsai_VEGFA_site1 GGGTGGGGGGAGTTTGCTCCTGG 41 AGGAAGGAGGAGTTAGCTCCTGG 70 0.000361500225938 5 0.245397590361 *..**..*......*..... 2 2 0.757342973339 Cho_ccr5-7 AACACCAGTGAGTAGAGCGGAGG 48 AACTCCAGTGAGGAGAGGGGTGG 55 0.00036 3 0.239002985075 ...*........*....*.. 0 0 0.42888 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 AGCACAGCAGCTGCAGGTGGGGG 75 0.000332681831413 4 0.0827921918513 *....*..*....*...... 1 1 0.956169168712 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 AGCACCGCTGCTGGGGGCGGGGG 75 0.000332681831413 5 0.0186798743777 *....*..*.....*..*.. 2 2 0.956169168712 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 AGCACTGGGGCCAGAGGTGAGGG 75 0.000332681831413 5 0.0763833363038 *......*...**......* 2 2 0.956169168712 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 AGCTCTGTGGCTGGAGGTGTGAG 75 0.000332681831413 4 0.697447183099 *..*...*...........* 1 1 0.956169168712 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 GGCACTGAGGCCGGAGGAGGAAG 75 0.000332681831413 3 0.271438222222 .......*...*.....*.. 0 0 0.956169168712 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 GGCACTGGGAATGGAGGTTGGGG 75 0.000332681831413 4 0.230366165286 .......*.**.......*. 1 1 0.956169168712 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 GGCACTGGGGCAGGAGTTGGGGG 75 0.000332681831413 3 0.506185654008 .......*...*....*... 0 0 0.956169168712 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 GGCCCTGCGGCCGGGGGTGGAGA 75 0.000332681831413 3 0.371150222222 ...*.......*..*..... 0 0 0.956169168712 Cho_ccr5 TGACATCAATTATTATACATCGG 27 TGACATAAATTATTTTACTTAGG 20 0.00033 3 0.171442619718 ......*.......*...*. 0 0 0.00182 Hsu_EMX1.3 GAGTCCGAGCAGAAGAAGAAGGG 22 AAGTCAGAGGAGAAGAAGAAGGG 50 0.000323472 3 1.48901476793 *....*...*.......... 0 0 0.291483904 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 CTCCCCCTCCACCCCACCTCCAG 80 0.000321983417854 3 0.541956882255 **.............*.... 0 0 0.978266119295 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 GACCCCCCCCCCCCGCCCCCGGG 80 0.000321983417854 5 0.00703981291034 .......*..*...**..*. 2 2 0.978266119295 Kim/Hap1_VEGFA GGGTGGGGGGAGTTTGCTCCTGG 41 CGGGGGAGGGAGTTTGCTCCTGG 70 0.00031 3 1.73721552878 *..*..*............. 0 0 0.06442 Cho_ccr5-2 GACACCGAAGCAGAGTTTTTAGG 50 GAAACAGAAGCAGAGTGTTTAGG 45 0.0003 3 0.723651235489 ..*..*..........*... 0 0 0.01731 Ran_EMX1-sg1 GCCTCCCCAAAGCCTGGCCAGGG 23 GGCCGCCCAGAGCCTGGCCAGAG 70 0.0003 4 1.25711206897 .*.**....*.......... 1 1 0.2904 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 AGCACTGCAGCGGGAGGTGAGAG 75 0.000291096602487 4 0.209660992606 *.......*..*.......* 1 1 0.956169168712 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 CAGGCTGCGCCTGGAGGTGGGGG 75 0.000291096602487 5 0.793288 ****.....*.......... 2 2 0.956169168712 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 GGCACCGAGGCCGGAGGTGCTGG 75 0.000291096602487 4 0.186579128165 .....*.*...*.......* 1 1 0.956169168712 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 GGCACCTTGGCTGAAGGTGGGGG 75 0.000291096602487 4 0.0840381943247 .....***.....*...... 1 1 0.956169168712 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 TGCACCGCGGCTGGGGCTGGAGG 75 0.000291096602487 4 0.0988378416667 *....*........*.*... 1 1 0.956169168712 Cho_ccr5-5 CCTGCCTCCGCTCTACTCACTGG 43 CCTGCCCTCACTCTACTCACAGG 65 0.00029 3 1.45931831502 ......**.*.......... 0 0 0.0169 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 AGTAGCCCCCACCCCGCCTCGGG 80 0.000281735490622 6 0.571855921856 *****..*............ 3 3 0.978266119295 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 CCCCCCCCCCCCCCCGCCCCGGG 80 0.000281735490622 5 0.168186075949 **.....*..*.......*. 2 2 0.978266119295 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 GACCCCACCCACCCCGCCGCAGG 80 0.000281735490622 3 0.639711267606 ......**..........*. 0 0 0.978266119295 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 GGCTCCCTCCGCCCCGCCCCGGG 80 0.000281735490622 4 0.27680625 .*.*......*.......*. 1 1 0.978266119295 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 TAGCCCCTCCACCCCACCACAGG 80 0.000281735490622 4 0.089349306338 *.*............*..*. 1 1 0.978266119295 Cho_c4bpb AATGACCACTACATCCTCAAGGG 47 AATGACCACTACATTCTCTTGGG 40 0.00028 3 0.0854226896552 ..............*...** 0 0 0.00301 Cho_ccr5-3 GGTCCTGCCGCTGCTTGTCATGG 50 GGTCCTGCTGCTGCTTGTCTGGG 65 0.00028 2 2.37301617647 ........*..........* -1 -1 0.00125 Cho_ccr5-4 AAATGAGAAGAAGAGGCACAGGG 10 AAATGAGGACAAGAGGCAGAGGG 40 0.00028 3 0.81662 .......*.*........*. 0 0 0.02015 Tsai_VEGFA_site3 GGTGAGTGAGTGTGTGCGTGTGG 6 AGTGAGTGAGTGTGAGTGCGGGG 60 0.000262031618482 4 0.0543602376761 *.............*.*.*. 1 1 0.893440475152 Tsai_VEGFA_site3 GGTGAGTGAGTGTGTGCGTGTGG 6 AGTGAGTGAGTGTGTGTGTGTGA 60 0.000262031618482 2 5.89919354839 *...............*... -1 -1 0.893440475152 Tsai_VEGFA_site3 GGTGAGTGAGTGTGTGCGTGTGG 6 TGTGAGTGAGTGTGTGTGTGTGA 60 0.000262031618482 2 5.89919354839 *...............*... -1 -1 0.893440475152 Cho_ccr5 TGACATCAATTATTATACATCGG 27 TGAAATCAATTTTTATACTTGGG 20 0.00026 3 0.488328358209 ...*.......*......*. 0 0 0.00182 Kim/Hap1_HBB CTTGCCCCACAGGGCAGTAACGG 46 GCTGCCCCACAGGGCAGCAAAGG 60 0.00026 3 0.656790123457 **...............*.. 0 0 0.01391 Cho_ccr5-4 AAATGAGAAGAAGAGGCACAGGG 10 AAATCATATGAAGAGGCACAAGG 40 0.00025 3 1.01263690932 ....*.*.*........... 0 0 0.02015 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 AGAACTGCTGCTGGAGGTGGTGG 75 0.00024951137356 3 1.60991195499 *.*.....*........... 0 0 0.956169168712 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 AGCACAGCGACTGAAGGTGAGGG 75 0.00024951137356 5 0.0333061036473 *....*...*...*.....* 2 2 0.956169168712 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 AGCACCATGGCTAGAGGTGTGGG 75 0.00024951137356 6 0.0424029533539 *....***....*......* 3 3 0.956169168712 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 GCCACTGGGGCTGGAGGGGGAGG 75 0.00024951137356 3 0.656790123457 .*.....*.........*.. 0 0 0.956169168712 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 GGCACCAGGCCTGGAGGTGTGGG 75 0.00024951137356 5 0.145313935029 .....***.*.........* 2 2 0.956169168712 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 GGCGCTGCGGCCCGAGGGGGTGG 75 0.00024951137356 4 0.0560968746835 ...*.......**....*.. 1 1 0.956169168712 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 GCCACCCACCACCCCACCTCAGG 80 0.00024148756339 4 0.258544303797 .*.*...*.......*.... 1 1 0.978266119295 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 TTCCCCTTCCACCCAGCCTCTGG 80 0.00024148756339 4 0.275145253165 **....*.......*..... 1 1 0.978266119295 Hsu_EMX1.3 GAGTCCGAGCAGAAGAAGAAGGG 22 GAGTCTGGGCAGGAGAAGAAGAG 50 0.000237892 3 0.595524096386 .....*.*....*....... 0 0 0.291483904 Cho_ccr-1 GAATCCTAAAAACTCTGCTTCGG 35 GAATCCTAAAATTTCTGCTTTGG 35 0.00023 2 0.993867032967 ...........**....... -1 -1 0.00219 Cho_ccr5-6 ATGAACACCAGTGAGTAGAGCGG 34 ATGAACACCAGTGAATAAAATGG 45 0.00023 3 0.0531518957854 ..............*..*.* 0 0 0.29692 Cho_ccr5 TGACATCAATTATTATACATCGG 27 TGACATCAATTAATTTTCATTGG 20 0.00022 3 0.0968943218391 ............*.*.*... 0 0 0.00182 Tsai_VEGFA_site3 GGTGAGTGAGTGTGTGCGTGTGG 6 GGAGAGTGAGTGTGTGCATGTGC 60 0.000218359682068 2 2.62276 ..*..............*.. -1 -1 0.893440475152 Tsai_VEGFA_site3 GGTGAGTGAGTGTGTGCGTGTGG 6 GGTGTGTGGGTGGGGGTGTGTGG 60 0.000218359682068 5 0.0223400015393 ....*...*...*.*.*... 2 2 0.893440475152 Cho_ccr-1 GAATCCTAAAAACTCTGCTTCGG 35 TAATCCTAAAAGCTCTGTTTTGG 35 0.00021 3 0.323140740741 *..........*.....*.. 0 0 0.00219 Kim/Hap1_VEGFA GGGTGGGGGGAGTTTGCTCCTGG 41 CCCGGGGGGAAGCTTGCTCCAGG 70 0.00021 6 0.21319615 ****.....*..*....... 3 3 0.06442 Kim/Hap1_VEGFA GGGTGGGGGGAGTTTGCTCCTGG 41 GGGAGGGTGGAGTTTGCTCCTGG 70 0.00021 2 6.01265822785 ...*...*............ -1 -1 0.06442 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 GCCACTGAGGCCGGAGGTGGAGA 75 0.000207926144633 3 1.38488888889 .*.....*...*........ 0 0 0.956169168712 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 GCCACTGGGCCTGGGGGTGGGGG 75 0.000207926144633 4 0.371023101266 .*.....*.*....*..... 1 1 0.956169168712 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 GCTGCTGCGGCTGGAGGTGGGGA 75 0.000207926144633 3 2.28742368742 .***................ 0 0 0.956169168712 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 GGCACTGAGGCTGCAGGCGGCGG 75 0.000207926144633 3 0.0822038518519 .......*.....*...*.. 0 0 0.956169168712 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 AACCCTCTCCACCCAGTCTCAGG 80 0.000201239636159 4 0.0988378416667 *....*........*.*... 1 1 0.978266119295 Cho_ccr-1 GAATCCTAAAAACTCTGCTTCGG 35 GAATTCTAAAAAGGCTGCTTTGG 35 0.0002 3 0.154092405063 ....*.......**...... 0 0 0.00219 Cho_ccr5 TGACATCAATTATTATACATCGG 27 TGACTTCACTTATGATACATGGG 20 0.0002 3 0.243282841069 ....*...*....*...... 0 0 0.00182 Cho_ccr5-4 AAATGAGAAGAAGAGGCACAGGG 10 AAATGAGAAGATCAGTCACAAGG 40 0.0002 3 0.0794687448276 ...........**..*.... 0 0 0.02015 Kim16_HEK3 GGCCCAGACTGAGCACGTGATGG 60 ATTCTAGACTGAGCACGTGCAAG 65 0.0002 5 0.395548253165 ***.*..............* 2 2 0.0013 Kim16_VEGFA1 GGGTGGGGGGAGTTTGCTCCAGG 41 GGGGGTGGGGAGCATGCTCCAGG 70 0.0002 4 0.0499123633283 ...*.*......**...... 1 1 0.0849 Ran_EMX1-sg1 GCCTCCCCAAAGCCTGGCCAGGG 23 ACCAACCCAGAGCCTGGCCAGGG 70 0.0002 4 1.31769578313 *..**....*.......... 1 1 0.2904 Hsu_EMX1.1 GTCACCTCCAATGACTAGGGTGG 68 GTCAACTCCAATGATTAGGACAG 55 0.000196232 3 0.352133333333 ....*.........*....* 0 0 0.030092945 Cho_ccr5 TGACATCAATTATTATACATCGG 27 TTACATCAATTATGATACAGTGG 20 0.00019 3 0.222321468927 .*...........*.....* 0 0 0.00182 Cho_ccr5-8 CCAGTGAGTAGAGCGGAGGCAGG 37 CCACTGAGTAGAGGGGTGGCGGG 65 0.00019 3 0.17056885759 ...*.........*..*... 0 0 0.02848 Tsai_EMX1 GAGTCCGAGCAGAAGAAGAAGGG 22 GAGCACGAGCAAGAGAAGAAGGG 50 0.000181405895692 4 0.272415361446 ...**......**....... 1 1 0.589931972789 Tsai_EMX1 GAGTCCGAGCAGAAGAAGAAGGG 22 GAGTCTAAGCAGGAGAATAAAGG 50 0.000181405895692 4 0.0471139635617 .....**.....*....*.. 1 1 0.589931972789 Cho_ccr-1 GAATCCTAAAAACTCTGCTTCGG 35 AAATCCTAAAGACTTTGCTTGGG 35 0.00018 3 0.468666666667 *.........*...*..... 0 0 0.00219 Tsai_VEGFA_site3 GGTGAGTGAGTGTGTGCGTGTGG 6 AGGGAGTGAGTGTGAGAGTGCGG 60 0.000174687745655 4 0.161081176667 *.*...........*.*... 1 1 0.893440475152 Tsai_VEGFA_site3 GGTGAGTGAGTGTGTGCGTGTGG 6 GGTGAGAGAGTGTGTGCACGGGG 60 0.000174687745655 3 0.125383408451 ......*..........**. 0 0 0.893440475152 Tsai_VEGFA_site3 GGTGAGTGAGTGTGTGCGTGTGG 6 TGTGAGAGAGTGTGTGTGTGGAG 60 0.000174687745655 3 0.881154320988 *.....*.........*... 0 0 0.893440475152 Cho_ccr5 TGACATCAATTATTATACATCGG 27 TGAAATGAATTATTAAACATTGG 20 0.00017 3 0.349302660407 ...*..*........*.... 0 0 0.00182 Hsu_EMX1.2 GACATCGATGTCCTCCCCATTGG 67 GACATGAATGACCTCCCCATCAG 55 0.000168796 3 0.556494530651 .....**...*......... 0 0 0.002124957 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 AGCACTGTTACAGGAGGTGGGGG 75 0.000166340915707 5 0.241857902897 *......***.*........ 2 2 0.956169168712 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 CACACTGCGGCCGGAGGTGACCG 75 0.000166340915707 4 0.343144014085 **.........*.......* 1 1 0.956169168712 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 GGCACTGCAACTGGAAGTGATGG 75 0.000166340915707 4 0.0577458619455 ........**.....*...* 1 1 0.956169168712 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 GGCACTGCAGCTGGCGGTGCTGG 75 0.000166340915707 3 0.192203763556 ........*.....*....* 0 0 0.956169168712 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 GGGCACGCGGCTGGAGGAGGGGG 75 0.000166340915707 5 0.107059167229 ..****...........*.. 1 GGCAC(T)GCGGCTGGAGGTGGGGG GGCACGCGGCTGGAGGAGGGGG 2 0.956169168712 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 CCCCACCCCCACCCCACCTCTGG 80 0.000160991708927 5 0.157493975904 **..*..*.......*.... 2 2 0.978266119295 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 CCCCCCCCTCACCCCGCCCCTGG 80 0.000160991708927 5 0.185156202532 **.....**.........*. 2 2 0.978266119295 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 GACCCCCCCCACCCCACCCCAGG 80 0.000160991708927 3 0.152506666667 .......*.......*..*. 0 0 0.978266119295 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 GGCCCTCTCCACTCCACCTCAGG 80 0.000160991708927 4 0.0605342705696 .*...*......*..*.... 1 1 0.978266119295 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 GGCTCACCCCACCCCACCTCTGG 80 0.000160991708927 5 0.0952838554217 .*.*.*.*.......*.... 2 2 0.978266119295 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 GTCCCCCTCCTCCCCGTCTCAGG 80 0.000160991708927 3 0.673271144279 .*........*.....*... 0 0 0.978266119295 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 TGCCCCCTCCACCCCACCTCTGA 80 0.000160991708927 3 0.541956882255 **.............*.... 0 0 0.978266119295 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 TTTCCCCCCCACCCCAACTCAGG 80 0.000160991708927 6 0.0415182556894 ***....*.......**... 3 3 0.978266119295 Kim/Hap1_VEGFA GGGTGGGGGGAGTTTGCTCCTGG 41 GCGTGGGGGGTGTTTGCTCCCGG 70 0.00015 2 4.46822033898 .*........*......... -1 -1 0.06442 Hsu_EMX1.3 GAGTCCGAGCAGAAGAAGAAGGG 22 GAATCCAAGCAGAAGAAGAGAAG 50 0.000147156 3 0.941031617989 ..*...*............* 0 0 0.291483904 Hsu_EMX1.2 GACATCGATGTCCTCCCCATTGG 67 GAAATCAAGGTCCTCCCCATAGG 55 0.000143751 3 1.04657854645 ..*...*.*........... 0 0 0.002124957 Cho_ccr-1 GAATCCTAAAAACTCTGCTTCGG 35 GCATCTTAAACACTCTGCTTGGG 35 0.00014 3 0.897289029536 .*...*....*......... 0 0 0.00219 Cho_ccr5 TGACATCAATTATTATACATCGG 27 TGACATCAAATATTACACAATGG 20 0.00014 3 0.185940485333 .........*.....*...* 0 0 0.00182 Cho_ccr5-3 GGTCCTGCCGCTGCTTGTCATGG 50 GGTGCTGATGCTGCTTGTCAGGG 65 0.00014 3 1.48263090677 ...*...**........... 0 0 0.00125 Cho_ccr5-6 ATGAACACCAGTGAGTAGAGCGG 34 ATGAACTCCTGTGAGTAGAGAGG 45 0.00014 2 3.59994487952 ......*..*.......... -1 -1 0.29692 Tsai_VEGFA_site3 GGTGAGTGAGTGTGTGCGTGTGG 6 GGGGGGTGAGTGTGTGTGTGGGG 60 0.000131015809241 3 1.19611774461 ..*.*...........*... 0 0 0.893440475152 Tsai_VEGFA_site3 GGTGAGTGAGTGTGTGCGTGTGG 6 TGTGAGAGAGAGTGTGCGTGTGG 60 0.000131015809241 3 1.06699777778 *.....*...*......... 0 0 0.893440475152 Cho_ccr-1 GAATCCTAAAAACTCTGCTTCGG 35 GAAACCTAAAAACACTACTTGGG 35 0.00013 3 0.17056885759 ...*.........*..*... 0 0 0.00219 Cho_ccr-1 GAATCCTAAAAACTCTGCTTCGG 35 GAATCCCCAAAACTCTTCTTTGG 35 0.00013 3 0.74016962963 ......**........*... 0 0 0.00219 Cho_ccr-1 GAATCCTAAAAACTCTGCTTCGG 35 GATTTATAAAAACTCTGCTTAGG 35 0.00013 3 1.38389133089 ..*.**.............. 0 0 0.00219 Cho_ccr5-4 AAATGAGAAGAAGAGGCACAGGG 10 AAATGAGAAAAATAGGCAGAGGG 40 0.00013 3 0.300030322785 .........*..*.....*. 0 0 0.02015 Kim/Hap1_HBB CTTGCCCCACAGGGCAGTAACGG 46 ATTGCCCCACGGGGCAGTGACGG 60 0.00013 3 0.625550847458 *.........*.......*. 0 0 0.01391 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 GGCACAGGGGCTGGAGGTGGGGC 75 0.00012475568678 2 3.30316091954 .....*.*............ -1 -1 0.956169168712 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 GGGCATGCGGCTGGAAGTGGTGG 75 0.00012475568678 4 0.254924683544 ..***..........*.... 1 1 0.956169168712 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 CCACCCCTCCACCCCGTCCCAGG 80 0.000120743781695 5 0.11503624557 ***.............*.*. 2 2 0.978266119295 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 CCTGCCCCCCACCCCGCCCCAGG 80 0.000120743781695 6 0.197496987952 ****...*..........*. 3 3 0.978266119295 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 CTCCCCCTACACCCCGCAACAGG 80 0.000120743781695 5 0.0362906156962 **......*........**. 2 2 0.978266119295 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 GACCCCCTTCACCCCACCTATGG 80 0.000120743781695 3 0.123354654222 ........*......*...* 0 0 0.978266119295 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 GTCCCCTCCCTCCCCGCCTCTGG 80 0.000120743781695 4 0.542336972892 .*....**..*......... 1 1 0.978266119295 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 TCCTCCTTCCACTCCGCCTCTGG 80 0.000120743781695 5 0.24202886747 **.*..*.....*....... 2 2 0.978266119295 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 TTCCCCCCCAACCCCACCTCGGG 80 0.000120743781695 5 0.145051951807 **.....*.*.....*.... 2 2 0.978266119295 Cho_ccr5-3 GGTCCTGCCGCTGCTTGTCATGG 50 GGGCCTGCTGCTGCTGGTCAAGG 65 0.00012 3 0.308105403443 ..*.....*......*.... 0 0 0.00125 Cho_ccr5-3 GGTCCTGCCGCTGCTTGTCATGG 50 GGTCCTGTCGCTGCTTGCCATGG 65 0.00012 2 1.69272727273 .......*.........*.. -1 -1 0.00125 Cho_ccr5-4 AAATGAGAAGAAGAGGCACAGGG 10 AAATGAGAATAAGAGGAACAGGG 40 0.00012 2 2.5138488806 .........*......*... -1 -1 0.02015 Ran_EMX1-sg2 GGCCAGGCTTTGGGGAGGCCTGG 15 GGCTGGGGTTTGGGGAGGCCCAG 75 0.00012 3 2.42656449553 ...**..*............ 0 0 0.00142 Cho_c4bpb AATGACCACTACATCCTCAAGGG 47 AAGAAGCACTACATCCTCAATGG 40 0.00011 3 1.38389133089 ..**.*.............. 0 0 0.00301 Kim/K562_VEGFA GGGTGGGGGGAGTTTGCTCCTGG 41 GGGAGGGTGGAGTTTGCTCCTGG 70 0.00011 2 6.01265822785 ...*...*............ -1 -1 0.032 Kim/K562_VEGFA GGGTGGGGGGAGTTTGCTCCTGG 41 GGGGAGGGGAAGTTTGCTCCTGG 70 0.00011 3 2.34257028112 ...**....*.......... 0 0 0.032 Hsu_EMX1.1 GTCACCTCCAATGACTAGGGTGG 68 GTCACCTCCACTTCCTAGGGCAG 55 0.000101458 3 0.0742437527473 ..........*.**...... 0 0 0.030092945 Cho_ccr5-8 CCAGTGAGTAGAGCGGAGGCAGG 37 CCACTGAGCAGAGAGGAGGCTGG 65 0.0001 3 0.256257925926 ...*....*....*...... 0 0 0.02848 Kim/K562_HBB CTTGCCCCACAGGGCAGTAACGG 46 GTGGCCCCACAGGGCAGGAATGG 60 0.0001 3 0.647595061728 *.*..............*.. 0 0 0.00791 Kim/K562_VEGFA GGGTGGGGGGAGTTTGCTCCTGG 41 CCCGGGGGGAAGCTTGCTCCAGG 70 0.0001 6 0.21319615 ****.....*..*....... 3 3 0.032 Ran_EMX1-sg1 GCCTCCCCAAAGCCTGGCCAGGG 23 GCGTGCCCAGAGCCTGGCCACAG 70 0.0001 3 2.30977429719 ..*.*....*.......... 0 0 0.2904 Cho_ccr-1 GAATCCTAAAAACTCTGCTTCGG 35 GATTCCTAAAACTTCTGCTTGGG 35 9e-05 3 0.528448672 ..*........**....... 0 0 0.00219 Cho_ccr5 TGACATCAATTATTATACATCGG 27 TCACATCAATTATTATAGCTTGG 20 9e-05 3 0.206888888889 .*...............**. 0 0 0.00182 Cho_ccr5-5 CCTGCCTCCGCTCTACTCACTGG 43 CCTGCCTCTGCTCTCCTCCCAGG 65 9e-05 3 0.145189893333 ........*.....*...*. 0 0 0.0169 Kim/Hap1_HBB CTTGCCCCACAGGGCAGTAACGG 46 GTGGCCCCACAGGGCAGGAATGG 60 9e-05 3 0.647595061728 *.*..............*.. 0 0 0.01391 Kim/K562_HBB CTTGCCCCACAGGGCAGTAACGG 46 GCTGCCCCACAGGGCAGCAAAGG 60 9e-05 3 0.656790123457 **...............*.. 0 0 0.00791 Hsu_EMX1.3 GAGTCCGAGCAGAAGAAGAAGGG 22 GAGTCCAAGAAGAATAAGAATAG 50 8.8e-05 3 0.450504494515 ......*..*....*..... 0 0 0.291483904 Tsai_HEK293_sgRNA4 GGCACTGCGGCTGGAGGTGGGGG 14 GACACTGCCTCTGGGGGTGGGGG 75 8.31704578534e-05 4 0.226695114873 .*......**....*..... 1 1 0.956169168712 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 AGCCCCCCCCTCCCCGCCCCAGG 80 8.04958544635e-05 5 0.168186075949 **.....*..*.......*. 2 2 0.978266119295 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 CAGCCCCTCCACTCCACCCCCGG 80 8.04958544635e-05 5 0.0198890198704 *.*.........*..*..*. 2 2 0.978266119295 Tsai_VEGFA_site2 GACCCCCTCCACCCCGCCTCCGG 29 CCCCCCCTCCACCCCACTTCAGG 80 8.04958544635e-05 4 0.0533773333333 **.............*.*.. 1 1 0.978266119295 Cho_ccr5 TGACATCAATTATTATACATCGG 27 TGTCACCAATTATTACACATTGG 20 8e-05 3 0.305079818466 ..*..*.........*.... 0 0 0.00182 Cho_ccr5-8 CCAGTGAGTAGAGCGGAGGCAGG 37 CCAGTGAGGAGAGCGGAGACTGG 65 8e-05 2 1.66219772727 ........*.........*. -1 -1 0.02848 Kim/K562_VEGFA GGGTGGGGGGAGTTTGCTCCTGG 41 CGGGGGAGGGAGTTTGCTCCTGG 70 8e-05 3 1.73721552878 *..*..*............. 0 0 0.032 Kim/K562_VEGFA GGGTGGGGGGAGTTTGCTCCTGG 41 GCGTGGGGGGTGTTTGCTCCCGG 70 8e-05 2 4.46822033898 .*........*......... -1 -1 0.032 Hsu_EMX1.1 GTCACCTCCAATGACTAGGGTGG 68 GTCACCTCCAGGGTCTAGGGCAG 55 7.57e-05 3 0.0943874065934 ..........**.*...... 0 0 0.030092945 Hsu_EMX1.3 GAGTCCGAGCAGAAGAAGAAGGG 22 GAGTCAGACCAGGAGAAGAAGAG 50 7.56e-05 3 0.363865222892 .....*..*...*....... 0 0 0.291483904 Cho_ccr5-5 CCTGCCTCCGCTCTACTCACTGG 43 CCAGTCTCCGCTCTCCTCACTGG 65 7e-05 3 0.785713928013 ..*.*.........*..... 0 0 0.0169 Cho_ccr5-8 CCAGTGAGTAGAGCGGAGGCAGG 37 CCAGTGAGCAGAGAGGAAGCTGG 65 7e-05 3 0.0476834368495 ........*....*...*.. 0 0 0.02848 Hsu_EMX1.3 GAGTCCGAGCAGAAGAAGAAGGG 22 GAGTCTGAACGGAAGAAGAAAAG 50 6.68e-05 3 0.49783039272 .....*..*.*......... 0 0 0.291483904 Hsu_EMX1.1 GTCACCTCCAATGACTAGGGTGG 68 GTCAACTCCAATGGCTTGGGAGG 55 6.45e-05 3 0.17056885759 ....*........*..*... 0 0 0.030092945 Cho_ccr5-3 GGTCCTGCCGCTGCTTGTCATGG 50 GGTCCTGCCGCTGCTCATCATGG 65 6e-05 2 0.345653846154 ...............**... -1 -1 0.00125 Ran_EMX1-sg2 GGCCAGGCTTTGGGGAGGCCTGG 15 GGTCAGGCTCCGGGGAGGCCGAG 75 6e-05 3 1.34683231646 ..*......**......... 0 0 0.00142 Ran_EMX1-sg2 GGCCAGGCTTTGGGGAGGCCTGG 15 GTTGAGGTTTTGGGGAGGCCCGG 75 6e-05 4 1.34583333333 .***...*............ 1 1 0.00142 Ran_EMX1-sg2 GGCCAGGCTTTGGGGAGGCCTGG 15 TGCCAGGCTCTGGGGAGGCCAAG 75 6e-05 2 7.41483050847 *........*.......... -1 -1 0.00142 Cho_ccr-1 GAATCCTAAAAACTCTGCTTCGG 35 GAATCCTAAATACTCTCCTTCGG 35 5e-05 2 1.42951584507 ..........*.....*... -1 -1 0.00219 Cho_ccr-1 GAATCCTAAAAACTCTGCTTCGG 35 GAATCCTCAATATTCTGCTTAGG 35 5e-05 3 0.521189655172 .......*..*.*....... 0 0 0.00219 Cho_ccr5 TGACATCAATTATTATACATCGG 27 TGACATCACTTATTATGCATGGG 20 5e-05 2 1.77359722222 ........*.......*... -1 -1 0.00182 Cho_ccr5 TGACATCAATTATTATACATCGG 27 TGACTTCAATGATTATACAGTGG 20 5e-05 3 0.729231343284 ....*.....*........* 0 0 0.00182 Cho_ccr5-7 AACACCAGTGAGTAGAGCGGAGG 48 AACACCAGTGAGAAGAGCTGTGG 55 5e-05 2 0.815561619718 ............*.....*. -1 -1 0.42888 Kim/K562_HBB CTTGCCCCACAGGGCAGTAACGG 46 ATTGCCCCACGGGGCAGTGACGG 60 5e-05 3 0.625550847458 *.........*.......*. 0 0 0.00791 Ran_EMX1-sg2 GGCCAGGCTTTGGGGAGGCCTGG 15 CGCCAGGCTCAGGGGAGGCCCGG 75 5e-05 3 1.43880666667 *........**......... 0 0 0.00142 Ran_EMX1-sg2 GGCCAGGCTTTGGGGAGGCCTGG 15 GGCCTGGCTTTGGGCAGGCCCAG 75 5e-05 2 2.31454545455 ....*.........*..... -1 -1 0.00142 Hsu_EMX1.3 GAGTCCGAGCAGAAGAAGAAGGG 22 GACTCCTAGCAAAAGAAGAATGG 50 4.8e-05 3 0.88541468692 ..*...*....*........ 0 0 0.291483904 Hsu_EMX1.1 GTCACCTCCAATGACTAGGGTGG 68 GTCACCTTAAATGACTTGGGAAG 55 4.17e-05 3 0.62861673699 .......**.......*... 0 0 0.030092945 Cho_ccr5-5 CCTGCCTCCGCTCTACTCACTGG 43 CCTGCCACAGCTCTACTCGCAGG 65 4e-05 3 0.390863584507 ......*.*.........*. 0 0 0.0169 Cho_ccr5-5 CCTGCCTCCGCTCTACTCACTGG 43 CCTGCCTCCTCACTCCTCACAGG 65 4e-05 3 0.294680478161 .........*.*..*..... 0 0 0.0169 Ran_EMX1-sg2 GGCCAGGCTTTGGGGAGGCCTGG 15 AGACAGGCTCTGGGGAGGCCTGG 75 4e-05 3 2.42672489451 *.*......*.......... 0 0 0.00142 Hsu_EMX1.3 GAGTCCGAGCAGAAGAAGAAGGG 22 GAGTCAGAGCAGAACTAGAAGGG 50 3.7e-05 3 0.0784997807407 .....*........**.... 0 0 0.291483904 Hsu_EMX1.3 GAGTCCGAGCAGAAGAAGAAGGG 22 GAGTCAGAACAGAAGAACAACAG 50 3.57e-05 3 0.215429611894 .....*..*........*.. 0 0 0.291483904 Hsu_EMX1.3 GAGTCCGAGCAGAAGAAGAAGGG 22 GAGTTCCAGAAGAAGAAGAAGAG 50 3.43e-05 3 1.52641340996 ....*.*..*.......... 0 0 0.291483904 Hsu_EMX1.3 GAGTCCGAGCAGAAGAAGAAGGG 22 GAGGCCCAGCAGAGGAAGAAGAG 50 3.28e-05 3 0.286455259259 ...*..*......*...... 0 0 0.291483904 Hsu_EMX1.3 GAGTCCGAGCAGAAGAAGAAGGG 22 GAGTCCCAGGAGAAGAAAAACAG 50 3.08e-05 3 0.347045352889 ......*..*.......*.. 0 0 0.291483904 Cho_ccr5-3 GGTCCTGCCGCTGCTTGTCATGG 50 GGTCCTCCCGCTGCTTCTCCGGG 65 3e-05 3 0.32603950939 ......*.........*..* 0 0 0.00125 Cho_ccr5-4 AAATGAGAAGAAGAGGCACAGGG 10 AAATGAGAACAAGAGGCAGAGGG 40 3e-05 2 2.33567161017 .........*........*. -1 -1 0.02015 Cho_ccr5-6 ATGAACACCAGTGAGTAGAGCGG 34 AGGAAAACCAGTGAGAAGAGTGG 45 3e-05 3 0.327883913765 .*...*.........*.... 0 0 0.29692 Hsu_EMX1.2 GACATCGATGTCCTCCCCATTGG 67 GACACCGATGTCATCTCCATCAG 55 2.27e-05 3 0.187365333333 ....*.......*..*.... 0 0 0.002124957 Cho_ccr5 TGACATCAATTATTATACATCGG 27 TGAAATCAATTATCATAGATCGG 20 2e-05 3 0.0920192371476 ...*.........*...*.. 0 0 0.00182 Cho_ccr5 TGACATCAATTATTATACATCGG 27 TGACATAAATTATTCTACATGGG 20 2e-05 2 1.38009365079 ......*.......*..... -1 -1 0.00182 Cho_ccr5-3 GGTCCTGCCGCTGCTTGTCATGG 50 GGTGCTGCTGCTGCTAGTCAGGG 65 2e-05 3 0.312480125196 ...*....*......*.... 0 0 0.00125 Hsu_EMX1.3 GAGTCCGAGCAGAAGAAGAAGGG 22 GAGTCCCAGCAGAGGAAGCAGAG 50 1.56e-05 3 0.0953169788732 ......*......*....*. 0 0 0.291483904 Hsu_EMX1.3 GAGTCCGAGCAGAAGAAGAAGGG 22 GAGTTTGAGTAGAAGAAGAAGAG 50 1.42e-05 3 1.35209386973 ....**...*.......... 0 0 0.291483904 Hsu_EMX1.3 GAGTCCGAGCAGAAGAAGAAGGG 22 GAGTACTAGAAGAAGAAGAAAAG 50 1.23e-05 3 1.52641340996 ....*.*..*.......... 0 0 0.291483904 Hsu_EMX1.3 GAGTCCGAGCAGAAGAAGAAGGG 22 GAGTAGGAGGAGAAGAAGAAAGG 50 1.22e-05 3 1.35209386973 ....**...*.......... 0 0 0.291483904 Hsu_EMX1.3 GAGTCCGAGCAGAAGAAGAAGGG 22 AAGTCCGAGAAGAAGCAGAAAAG 50 1.12e-05 3 0.499142288557 *........*.....*.... 0 0 0.291483904 Hsu_EMX1.3 GAGTCCGAGCAGAAGAAGAAGGG 22 GAGTCCCAGGAGAAGAAGAGAGG 50 1e-05 3 0.77995425493 ......*..*.........* 0 0 0.291483904 Cho_ccr-1 GAATCCTAAAAACTCTGCTTCGG 35 GAACCCTCAAAACTCTGTTTGGG 35 0.0 3 0.617578772803 ...*...*.........*.. 0 0 0.00219 Cho_ccr5-2 GACACCGAAGCAGAGTTTTTAGG 50 GTCAACGAAGCAGAGTTGTTGGG 45 0.0 3 0.656790123457 .*..*............*.. 0 0 0.01731 Cho_ccr5-3 GGTCCTGCCGCTGCTTGTCATGG 50 CGTCCTGCCACTGCATGTCATGG 65 0.0 3 0.777733333333 *........*....*..... 0 0 0.00125 Cho_ccr5-3 GGTCCTGCCGCTGCTTGTCATGG 50 GATCCTGCCGTTGCCTGTCATGG 65 0.0 3 0.442262910798 .*........*...*..... 0 0 0.00125 Cho_ccr5-3 GGTCCTGCCGCTGCTTGTCATGG 50 GGCCCTGCCGCTGCATGACATGG 65 0.0 3 0.163193955556 ..*...........*..*.. 0 0 0.00125 Cho_ccr5-3 GGTCCTGCCGCTGCTTGTCATGG 50 GGTCCTGCTGCAGCTTCTCATGG 65 0.0 3 0.309279434599 ........*..*....*... 0 0 0.00125 Cho_ccr5-3 GGTCCTGCCGCTGCTTGTCATGG 50 GGTCCTGGCGCTGCTTCTCCAGG 65 0.0 3 0.477363849765 .......*........*..* 0 0 0.00125 Cho_ccr5-4 AAATGAGAAGAAGAGGCACAGGG 10 AAAAGAGAAGCTGAGGCACAGGG 40 0.0 3 0.729696202532 ...*......**........ 0 0 0.02015 Cho_ccr5-4 AAATGAGAAGAAGAGGCACAGGG 10 AAACGAGAAGAAGCTGCACATGG 40 0.0 3 0.112401185185 ...*.........**..... 0 0 0.02015 Cho_ccr5-4 AAATGAGAAGAAGAGGCACAGGG 10 AAAGGAGAAGGAGAGGCAGATGG 40 0.0 3 0.550858208955 ...*......*.......*. 0 0 0.02015 Cho_ccr5-4 AAATGAGAAGAAGAGGCACAGGG 10 AAATGAGAAGGAGTGGCAGATGG 40 0.0 3 0.0696103481013 ..........*..*....*. 0 0 0.02015 Cho_ccr5-4 AAATGAGAAGAAGAGGCACAGGG 10 AAATGAGAAGTTGAGGCTCATGG 40 0.0 3 0.136127903614 ..........**.....*.. 0 0 0.02015 Cho_ccr5-5 CCTGCCTCCGCTCTACTCACTGG 43 CCTGCCTCCGCGCTGCTCTCGGG 65 0.0 3 0.105643662651 ...........*..*...*. 0 0 0.0169 Cho_ccr5-5 CCTGCCTCCGCTCTACTCACTGG 43 CCTGCCTCCTCTCTATTCTCCGG 65 0.0 3 0.133346810127 .........*.....*..*. 0 0 0.0169 Cho_ccr5-5 CCTGCCTCCGCTCTACTCACTGG 43 CCTGCCTCCTGTCTACTCTCAGG 65 0.0 3 0.430276044304 .........**.......*. 0 0 0.0169 Cho_ccr5-5 CCTGCCTCCGCTCTACTCACTGG 43 CCTGGCTCCTCTCTCCTCACTGG 65 0.0 3 0.694775111111 ....*....*....*..... 0 0 0.0169 Cho_ccr5-5 CCTGCCTCCGCTCTACTCACTGG 43 CCTGTCTCCTCTCCACTCACTGG 65 0.0 3 0.366716033755 ....*....*...*...... 0 0 0.0169 Cho_ccr5-6 ATGAACACCAGTGAGTAGAGCGG 34 AAGGACACCAGTGAGGAGAGTGG 45 0.0 3 0.541956882255 .*.*...........*.... 0 0 0.29692 Cho_ccr5-6 ATGAACACCAGTGAGTAGAGCGG 34 AGGAACACCAGTGGGAAGAGAGG 45 0.0 3 0.0807515754561 .*...........*.*.... 0 0 0.29692 Cho_ccr5-6 ATGAACACCAGTGAGTAGAGCGG 34 ATGAACACCAGTGAATACATAGG 45 0.0 3 0.0531518957854 ..............*..*.* 0 0 0.29692 Cho_ccr5-6 ATGAACACCAGTGAGTAGAGCGG 34 ATGAACCCTAGTGAGAAGAGAGG 45 0.0 3 0.19181137609 ......*.*......*.... 0 0 0.29692 Cho_ccr5-6 ATGAACACCAGTGAGTAGAGCGG 34 ATGAACTCCAGGGAGAAGAGAGG 45 0.0 3 0.154453677637 ......*....*...*.... 0 0 0.29692 Cho_ccr5-7 AACACCAGTGAGTAGAGCGGAGG 48 AAAACCAGTGAGCAGAGTGGAGG 55 0.0 3 0.235656943284 ..*.........*....*.. 0 0 0.42888 Cho_ccr5-7 AACACCAGTGAGTAGAGCGGAGG 48 AAAAGCAGAGAGTAGAGCGGTGG 55 0.0 3 1.53232583668 ..*.*...*........... 0 0 0.42888 Cho_ccr5-8 CCAGTGAGTAGAGCGGAGGCAGG 37 ACAGTGAGTAGAGTGGAGTCCGG 65 0.0 3 0.167940677966 *............*....*. 0 0 0.02848 Cho_ccr5-8 CCAGTGAGTAGAGCGGAGGCAGG 37 CCAGTGAGGAGAGAGGAGCCAGG 65 0.0 3 0.0807212466667 ........*....*....*. 0 0 0.02848 Cho_ccr5-8 CCAGTGAGTAGAGCGGAGGCAGG 37 CCAGTGAGTGGAGAGGAGACAGG 65 0.0 3 0.115515550633 .........*...*....*. 0 0 0.02848 Cho_ccr5-8 CCAGTGAGTAGAGCGGAGGCAGG 37 CCGGTGGGGAGAGCGGAGGCGGG 65 0.0 3 1.04657854645 ..*...*.*........... 0 0 0.02848 Cho_ccr5-8 CCAGTGAGTAGAGCGGAGGCAGG 37 GCAGAGAGTAGAGCGGTGGCTGG 65 0.0 3 1.29012345679 *...*...........*... 0 0 0.02848 Hsu_EMX1.1 GTCACCTCCAATGACTAGGGTGG 68 GTCACTTCCAAGGACTAGAGAAG 55 0.0 3 0.278794225352 .....*.....*......*. 0 0 0.030092945 Hsu_EMX1.2 GACATCGATGTCCTCCCCATTGG 67 GACATCGATAGCCTCCCCACTGG 55 0.0 3 0.59998238 .........**........* 0 0 0.002124957 Hsu_EMX1.3 GAGTCCGAGCAGAAGAAGAAGGG 22 GAGAGCAAGCAGAAGAAGAAAAG 50 0.0 3 1.58449328449 ...**.*............. 0 0 0.291483904 Hsu_EMX1.3 GAGTCCGAGCAGAAGAAGAAGGG 22 GAGTAAGAGAAGAAGAAGAAGGG 50 0.0 3 1.35209386973 ....**...*.......... 0 0 0.291483904 Hsu_EMX1.3 GAGTCCGAGCAGAAGAAGAAGGG 22 GAGTCCAAGCAGAGGAAGGATAG 50 0.0 3 0.0953169788732 ......*......*....*. 0 0 0.291483904 Hsu_EMX1.3 GAGTCCGAGCAGAAGAAGAAGGG 22 GAGTCCCAGCAAAAGAAGAAAAG 50 0.0 2 2.128228 ......*....*........ -1 -1 0.291483904 Hsu_EMX1.3 GAGTCCGAGCAGAAGAAGAAGGG 22 GAGTCCGAGAAAATGAAGAAGAG 50 0.0 3 0.163833549425 .........*.*.*...... 0 0 0.291483904 Hsu_EMX1.3 GAGTCCGAGCAGAAGAAGAAGGG 22 GATTCCTACCAGAAGAAGAATGG 50 0.0 3 1.04657854645 ..*...*.*........... 0 0 0.291483904 Hsu_EMX1.6 GCGCCACCGGTTGATGTGATGGG 88 GGGCCATGGGTTGATGTGATGAG 60 0.0 3 1.73721552878 .*....**............ 0 0 0.0 Ran_EMX1-sg1 GCCTCCCCAAAGCCTGGCCAGGG 23 GCCTGCCGAAGGCCTGGCCAGGG 70 0.0 3 1.41164658635 ....*..*..*......... 0 0 0.2904 Ran_EMX1-sg1 GCCTCCCCAAAGCCTGGCCAGGG 23 GCTGCCCGAGAGCCTGGCCATGG 70 0.0 4 1.2395125 ..**...*.*.......... 1 1 0.2904