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["Pathway name in GSEA","Top level pathway (Figure 1)","Pathway size","Enrichment score (ES)","Normalized ES","p-value","q-value","Number of pathway genes DE in PIVUS at 5% FDR","Proportion of pathway genes DE in PIVUS"]
["REACTOME_METABOLISM_OF_RNA","Metabolism of RNA",233,0.5732066,2.3254247,"<=1e-04","<=1e-04",31,0.13304721030042918]
["REACTOME_ACTIVATION_OF_THE_MRNA_UPON_BINDING_OF_THE_CAP_BINDING_COMPLEX_AND_EIFS_AND_SUBSEQUENT_BINDING_TO_43S","Metabolism of proteins",52,0.7168209,2.3313575,"<=1e-04","<=1e-04",8,0.15384615384615385]
["KEGG_PARKINSONS_DISEASE","Neurodegenerative diseases",89,0.66045076,2.366772,"<=1e-04","<=1e-04",10,0.11235955056179775]
["REACTOME_INFLUENZA_LIFE_CYCLE","Infectious diseases",131,0.6352767,2.3915298,"<=1e-04","<=1e-04",22,0.16793893129770993]
["REACTOME_INFLUENZA_VIRAL_RNA_TRANSCRIPTION_AND_REPLICATION","Infectious diseases",99,0.6801039,2.4679973,"<=1e-04","<=1e-04",20,0.20202020202020202]
["REACTOME_METABOLISM_OF_MRNA","Metabolism of RNA",191,0.62853557,2.4914806,"<=1e-04","<=1e-04",26,0.13612565445026178]
["REACTOME_NONSENSE_MEDIATED_DECAY_ENHANCED_BY_THE_EXON_JUNCTION_COMPLEX","Metabolism of RNA",101,0.71332973,2.5933998,"<=1e-04","<=1e-04",17,0.16831683168316833]
["REACTOME_3_UTR_MEDIATED_TRANSLATIONAL_REGULATION","Metabolism of proteins",101,0.7276176,2.647746,"<=1e-04","<=1e-04",20,0.19801980198019803]
["REACTOME_PEPTIDE_CHAIN_ELONGATION","Metabolism of proteins",84,0.75331956,2.670504,"<=1e-04","<=1e-04",18,0.21428571428571427]
["REACTOME_TRANSLATION","Metabolism of proteins",139,0.7079983,2.687864,"<=1e-04","<=1e-04",28,0.2014388489208633]
["KEGG_RIBOSOME","Ribosome",77,0.77763784,2.7124271,"<=1e-04","<=1e-04",17,0.22077922077922077]
["REACTOME_SRP_DEPENDENT_COTRANSLATIONAL_PROTEIN_TARGETING_TO_MEMBRANE","Metabolism of proteins",105,0.7422114,2.7257984,"<=1e-04","<=1e-04",23,0.21904761904761905]
["REACTOME_RESPIRATORY_ELECTRON_TRANSPORT_ATP_SYNTHESIS_BY_CHEMIOSMOTIC_COUPLING_AND_HEAT_PRODUCTION_BY_UNCOUPLING_PROTEINS_","Metabolism",65,0.6640132,2.239528,"<=1e-04",8.41e-06,9,0.13846153846153847]
["REACTOME_TCA_CYCLE_AND_RESPIRATORY_ELECTRON_TRANSPORT","Metabolism",100,0.6186404,2.2440104,"<=1e-04",9.01e-06,10,0.1]
["REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX","Metabolism of proteins",47,0.71596617,2.2744176,"<=1e-04",9.71e-06,7,0.14893617021276595]
["KEGG_OXIDATIVE_PHOSPHORYLATION","Oxidative phosphorylation",85,0.62583596,2.2208052,"<=1e-04",1.62e-05,11,0.12941176470588237]
["REACTOME_ER_PHAGOSOME_PATHWAY","Adaptive immune system",52,0.66650826,2.172826,"<=1e-04",4.59e-05,7,0.1346153846153846]
["REACTOME_RESPIRATORY_ELECTRON_TRANSPORT","Metabolism",53,0.658968,2.1479266,"<=1e-04",9.29e-05,6,0.11320754716981132]
["KEGG_HUNTINGTONS_DISEASE","Neurodegenerative diseases",139,0.55422,2.110729,"<=1e-04",0.000169799,15,0.1079136690647482]
["REACTOME_METABOLISM_OF_PROTEINS","Metabolism of proteins",358,0.49469346,2.0912862,"<=1e-04",0.000226904,47,0.13128491620111732]
["REACTOME_CROSS_PRESENTATION_OF_SOLUBLE_EXOGENOUS_ANTIGENS_ENDOSOMES","Adaptive immune system",38,0.6702492,2.033463,"<=1e-04",0.000814164,5,0.13157894736842105]
["REACTOME_CDK_MEDIATED_PHOSPHORYLATION_AND_REMOVAL_OF_CDC6","Cell cycle and DNA replication",40,0.65483975,2.0222178,"<=1e-04",0.000922846,5,0.125]
["REACTOME_SIGNALING_BY_WNT","Cell signaling",56,0.612605,2.012359,"<=1e-04",0.001088563,5,0.08928571428571429]
["KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION","Cytokine-cytokine receptor interaction",140,-0.57739323,-2.093366,"<=1e-04",0.001240575,17,0.12142857142857143]
["REACTOME_ANTIGEN_PROCESSING_CROSS_PRESENTATION","Adaptive immune system",61,0.5893744,1.9815221,"<=1e-04",0.00178938,8,0.13114754098360656]
["KEGG_PROTEASOME","Proteasome Complex",36,0.65602756,1.9784527,"<=1e-04",0.001805169,5,0.1388888888888889]
["REACTOME_DESTABILIZATION_OF_MRNA_BY_AUF1_HNRNP_D0","Metabolism",44,0.62942785,1.9706347,"<=1e-04",0.001952626,5,0.11363636363636363]
["REACTOME_SCFSKP2_MEDIATED_DEGRADATION_OF_P27_P21","Cell cycle",46,0.61731297,1.9649609,"<=1e-04",0.00209801,5,0.10869565217391304]
["HALLMARK_MYC_TARGETS_V1","A subgroup of genes regulated by MYC",183,0.49749354,1.951593,"<=1e-04",0.002418033,20,0.1092896174863388]
["HALLMARK_OXIDATIVE_PHOSPHORYLATION","Oxidative phosphorylation",175,0.49790084,1.9536735,"<=1e-04",0.002421294,10,0.05714285714285714]
["REACTOME_CDT1_ASSOCIATION_WITH_THE_CDC6_ORC_ORIGIN_COMPLEX","Cell cycle and DNA replication",49,0.60591394,1.9444656,0.000228206,0.002593248,5,0.10204081632653061]
["REACTOME_P53_DEPENDENT_G1_DNA_DAMAGE_RESPONSE","Cell cycle",47,0.60373944,1.9299148,0.000231054,0.003270332,6,0.1276595744680851]
["REACTOME_REGULATION_OF_ORNITHINE_DECARBOXYLASE_ODC","Metabolism",42,0.61399484,1.9057072,"<=1e-04",0.004426584,5,0.11904761904761904]
["REACTOME_CYCLIN_E_ASSOCIATED_EVENTS_DURING_G1_S_TRANSITION_","Cell cycle",55,0.58230436,1.9072715,"<=1e-04",0.004459176,5,0.09090909090909091]
["REACTOME_P53_INDEPENDENT_G1_S_DNA_DAMAGE_CHECKPOINT","Cell cycle",43,0.6099785,1.897226,0.000449438,0.004834421,5,0.11627906976744186]
["BIOCARTA_PROTEASOME_PATHWAY","Proteasome Complex",24,0.68763137,1.893119,0.001314636,0.005023087,5,0.20833333333333334]
["REACTOME_AUTODEGRADATION_OF_THE_E3_UBIQUITIN_LIGASE_COP1","Cell cycle",42,0.6064649,1.8894572,"<=1e-04",0.005157099,6,0.14285714285714285]
["REACTOME_SIGNALING_BY_FGFR_MUTANTS","Cell signaling",29,0.6508757,1.8659323,0.001111852,0.007160149,0,0]
["REACTOME_SCF_BETA_TRCP_MEDIATED_DEGRADATION_OF_EMI1","Cell cycle",44,0.594533,1.8632715,0.000678887,0.007290018,6,0.13636363636363635]
["REACTOME_VIF_MEDIATED_DEGRADATION_OF_APOBEC3G","Infectious diseases",42,0.5903549,1.8321729,0.000456204,0.011043451,6,0.14285714285714285]
["REACTOME_CLASS_A1_RHODOPSIN_LIKE_RECEPTORS","Cell signaling",109,-0.5633114,-1.9695163,"<=1e-04",0.011200854,16,0.14678899082568808]
["HALLMARK_INFLAMMATORY_RESPONSE","Inflammatory response",143,-0.5279089,-1.9288722,"<=1e-04",0.012415286,14,0.0979020979020979]
["REACTOME_ORC1_REMOVAL_FROM_CHROMATIN","Cell cycle and DNA replication",58,0.54947865,1.8215452,0.000702576,0.012523689,6,0.10344827586206896]
["HALLMARK_TNFA_SIGNALING_VIA_NFKB","Genes regulated by NF-kB in response to TNF",160,-0.52592564,-1.9424099,"<=1e-04",0.013145229,26,0.1625]
["KEGG_ALZHEIMERS_DISEASE","Neurodegenerative diseases",127,0.4825975,1.814285,"<=1e-04",0.013582728,13,0.10236220472440945]
["REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS","Cell signaling",59,-0.57945955,-1.8497963,0.000354233,0.020249527,10,0.1694915254237288]
["REACTOME_PD1_SIGNALING","Adaptive immune system",17,-0.7475073,-1.8423464,0.00075643,0.020635815,2,0.11764705882352941]
["REACTOME_SIGNALING_BY_FGFR1_FUSION_MUTANTS","Diseases of cell signaling",17,0.70226604,1.7758312,0.003173932,0.021583086,0,0]
["HALLMARK_ALLOGRAFT_REJECTION","Immune diseases",159,-0.50124663,-1.8516932,"<=1e-04",0.021800244,12,0.07547169811320754]
["REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES","Cell signaling",25,-0.698685,-1.862915,0.001659904,0.023601498,6,0.24]
["REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL","Adaptive immune system",45,-0.6150574,-1.8535087,0.000180766,0.023923503,3,0.06666666666666667]
["HALLMARK_UV_RESPONSE_DN","Genes down-regulated in response to ultraviolet (UV) radiation",118,0.47393838,1.7630847,"<=1e-04",0.02451803,10,0.0847457627118644]
["KEGG_ASTHMA","Immune diseases",20,-0.735511,-1.87079,0.000737055,0.024522865,4,0.2]
["KEGG_LEISHMANIA_INFECTION","Infectious diseases",57,-0.5929664,-1.8764803,"<=1e-04",0.026590053,6,0.10526315789473684]
["REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES","Cytokine signaling in immune system",61,0.52155906,1.7533671,0.000460511,0.026855046,6,0.09836065573770492]
["REACTOME_SIGNALING_BY_FGFR1_MUTANTS","Diseases of cell signaling",20,0.6582608,1.7508111,0.003462454,0.027137728,0,0]
["REACTOME_REGULATION_OF_APOPTOSIS","Programmed cell death",50,0.54327697,1.7476528,0.001338987,0.027598979,6,0.12]
["BIOCARTA_TGFB_PATHWAY","TGF beta signaling pathway",18,0.6670271,1.7364856,0.005782823,0.030711818,1,0.05555555555555555]
["KEGG_DORSO_VENTRAL_AXIS_FORMATION","Organismal Systems - Development",18,0.67438895,1.7344091,0.004934563,0.030746778,1,0.05555555555555555]
["KEGG_GRAFT_VERSUS_HOST_DISEASE","Immune diseases",30,-0.6472756,-1.8035734,0.001099304,0.033190563,3,0.1]
["REACTOME_ASSEMBLY_OF_THE_PRE_REPLICATIVE_COMPLEX","Cell cycle and DNA replication",58,0.5189509,1.7214776,0.001857441,0.03457976,6,0.10344827586206896]
["REACTOME_GPCR_LIGAND_BINDING","Cell signaling",158,-0.48421994,-1.7874727,"<=1e-04",0.03810631,17,0.10759493670886076]
["REACTOME_PHOSPHORYLATION_OF_CD3_AND_TCR_ZETA_CHAINS","Adaptive immune system",15,-0.7394324,-1.7756687,0.003203316,0.03837617,2,0.13333333333333333]
["BIOCARTA_VIP_PATHWAY","Adaptive immune system",23,-0.67150295,-1.7809801,0.003690037,0.0383819,1,0.043478260869565216]
["REACTOME_REGULATION_OF_MRNA_STABILITY_BY_PROTEINS_THAT_BIND_AU_RICH_ELEMENTS","Metabolism of RNA",71,0.49533546,1.7081711,0.001172058,0.03923225,8,0.11267605633802817]
["REACTOME_SYNTHESIS_OF_PIPS_AT_THE_GOLGI_MEMBRANE","Metabolism",15,0.6915548,1.693548,0.008684325,0.044844527,2,0.13333333333333333]