hgvs SE epsilon score p.(S10del) 0.627230304 6.05E-05 -0.56659478 p.(I11del) 1.030976413 0 1.833325054 p.(V12del) 0.321047694 2.76E-23 4.206671126 p.(S13del) 0.333094021 1.50E-41 -0.495455579 p.(S14del) 0.463000125 2.80E-09 0.377995846 p.(E15del) 0.626134417 2.27E-29 0.397720076 p.(D17del) 0.565759762 5.99E-16 -0.460328104 p.(G18del) 0.586403165 1.63E-32 0.323028965 p.(M19del) 0.589589196 4.11E-39 0.471319952 p.(G2del) 1.271054581 0 0.155718275 p.(K20del) 0.585893079 8.94E-24 -0.242279982 p.(L21del) 0.850601309 3.10E-12 -1.303361116 p.(A22del) 0.518195644 1.34E-10 -0.674458557 p.(T23del) 0.75287006 1.29E-23 -1.164682577 p.(M24del) 1.134754224 1.97E-06 -1.378731645 p.(A25del) 0.602868269 1.52E-11 -0.821025169 p.(V26del) 1.40825457 0 1.450032319 p.(A27del) 0.931785745 0 1.198151186 p.(N28del) 0.966967996 0 0.307111997 p.(G29del) 0.610136498 1.69E-09 -2.173675547 p.(S3del) 0.253687807 5.33E-37 -3.824609449 p.(F30del) 0.263678613 1.85E-14 1.85786536 p.(G31del) 0.2598469 2.22E-20 -1.123797754 p.(N32del) 0.512935184 2.77E-08 1.301778867 p.(G33del) 0.50284314 2.10E-10 -1.321345676 p.(K34del) 0.711128713 1.09E-10 0.94324429 p.(S35del) 0.523530101 1.11E-16 -0.679235293 p.(K36del) 0.796175558 1.58E-14 2.09869935 p.(V37del) 0.568520035 2.22E-16 0.410854084 p.(H38del) 1.602219778 3.34E-13 0.614656223 p.(T39del) 0.502987047 1.11E-16 -0.046413073 p.(V4del) 0.448215181 8.78E-24 0.162104345 p.(R40del) 0.761896303 0 -0.080113998 p.(Q41del) 0.51500069 1.70E-25 0.792665106 p.(Q42del) 0.253636997 9.20E-21 0.417033687 p.(C43del) 0.328939983 0.000979973 -0.656434457 p.(R44del) 0.337802794 1.60E-21 0.854811399 p.(S45del) 0.897856826 8.10E-25 -0.02175016 p.(R46del) 0.859175461 9.71E-14 -0.862259589 p.(F47del) 1.694484605 2.66E-15 -3.4001985 p.(V48del) 1.139551544 3.60E-34 -1.416391735 p.(R5del) 0.29796059 2.28E-42 0.621349823 p.(T6del) 0.593784609 4.00E-68 0.324958037 p.(N7del) 0.334719817 0.000144911 -0.129548052 p.(R8del) 0.673672604 3.98E-46 0.281219032 p.(Y9del) 1.176940484 0 1.824031855 p.(S10_I11del) 0.783544852 2.36E-08 -1.16892301 p.(I11_V12del) 0.754219941 0 0.742275774 p.(V12_S13del) 0.460031394 0 0.958095924 p.(S13_S14del) 0.518033218 3.85E-13 0.312082039 p.(S14_E15del) 0.500140543 2.91E-66 -0.357331167 p.(E15_E16del) 0.71812055 9.29E-83 -0.576091715 p.(E16_D17del) 1.020876076 1.06E-50 -0.116606542 p.(D17_G18del) 0.542028962 1.18E-83 0.038420735 p.(G18_M19del) 0.369746437 2.89E-10 -0.010349095 p.(M19_K20del) 0.681159546 3.60E-13 0.345260707 p.(G2_S3del) 0.996287879 4.70E-30 -0.51017703 p.(K20_L21del) 0.891560578 1.17E-48 -0.019986105 p.(L21_A22del) 0.310378398 3.11E-38 0.311717723 p.(A22_T23del) 1.048794263 8.60E-61 -0.161856589 p.(T23_M24del) 0.380544191 2.90E-10 0.978741754 p.(M24_A25del) 0.353794951 4.40E-07 1.978824621 p.(A25_V26del) 0.279999638 2.84E-10 1.486671712 p.(V26_A27del) 0.426097698 5.55E-17 1.043662449 p.(A27_N28del) 0.157122781 7.39E-54 0.401014904 p.(N28_G29del) 0.610443102 3.02E-68 0.216007572 p.(G29_F30del) 0.340946001 6.50E-28 0.347519935 p.(S3_V4del) 0.861569492 5.98E-94 -0.491156228 p.(F30_G31del) 0.901663095 0 2.38045874 p.(G31_N32del) 0.404931019 4.22E-49 0.546756064 p.(N32_G33del) 0.106975821 9.03E-31 -0.431776093 p.(G33_K34del) 0.298279301 2.03E-35 1.607291883 p.(K34_S35del) 0.264049755 5.38E-10 0.818709542 p.(S35_K36del) 0.208374583 9.71E-17 1.567540348 p.(K36_V37del) 0.382130885 1.60E-62 0.780915801 p.(V37_H38del) 0.17855714 8.66E-85 1.121789193 p.(H38_T39del) 0.424290721 6.54E-21 0.312121787 p.(T39_R40del) 0.365652189 3.63E-64 0.379858141 p.(V4_R5del) 0.663172806 9.83E-49 0.577513629 p.(R40_Q41del) 0.137885668 8.34E-09 1.07663037 p.(Q41_Q42del) 0.333808975 1.91E-48 0.483506648 p.(Q42_C43del) 0.39663813 6.70E-41 0.669285808 p.(C43_R44del) 0.305219959 5.74E-06 1.828189076 p.(R44_S45del) 0.344203911 1.70E-17 1.244754663 p.(S45_R46del) 0.050586737 2.30E-14 0.121035905 p.(R46_F47del) 0.449640037 9.49E-61 0.349991826 p.(F47_V48del) 0.350416066 8.36E-07 -4.51655926 p.(V48_K49del) 0.748394783 2.17E-07 -3.727516575 p.(R5_T6del) 0.461196069 9.70E-148 1.382898142 p.(T6_N7del) 0.493703655 2.04E-11 0.870586508 p.(N7_R8del) 0.296887368 1.39E-17 1.757190489 p.(R8_Y9del) 0.575319917 2.21E-09 2.391890085 p.(Y9_S10del) 0.699969109 0 1.868459464 p.(S10_V12del) 0.218891106 8.37E-34 1.286983457 p.(I11_S13del) 0.648552863 0 1.702032923 p.(V12_S14del) 0.487565753 0 1.114824578 p.(S13_E15del) 0.955174117 1.07E-93 -0.076424546 p.(S14_E16del) 0.926057006 1.53E-14 -0.243817163 p.(E15_D17del) 0.816943485 1.85E-19 -2.431840222 p.(E16_G18del) 0.846001583 2.95E-48 -0.527465131 p.(D17_M19del) 0.547619438 0.001673177 0.476409109 p.(G18_K20del) 0.827263168 7.61E-37 -0.333412665 p.(M19_L21del) 0.738532829 0.003677651 0.161653775 p.(G2_V4del) 0.831093473 7.73E-57 -0.200803031 p.(K20_A22del) 0.346827785 1.89E-50 0.262998903 p.(L21_T23del) 0.768765449 0 1.153691096 p.(A22_M24del) 0.07264769 5.83E-14 -1.009323098 p.(T23_A25del) 0.400517178 4.87E-09 -1.138415429 p.(M24_V26del) 0.313874412 0.000613833 0.886746242 p.(A25_A27del) 0.428351333 3.75E-44 1.060407027 p.(V26_N28del) 0.248867306 1.40E-05 0.938767389 p.(A27_G29del) 0.654058213 2.47E-92 -0.332464088 p.(N28_F30del) 0.452902947 0 2.543595735 p.(G29_G31del) 0.312909859 1.49E-09 0.190782154 p.(S3_R5del) 0.514685305 7.93E-113 -0.387612104 p.(F30_N32del) 0.657785587 4.44E-16 1.607460872 p.(G31_G33del) 0.536162455 4.69E-12 1.007864816 p.(N32_K34del) 0.36653876 5.55E-17 0.520774505 p.(G33_S35del) 0.36347152 1.26E-16 1.143711231 p.(K34_K36del) 0.215241344 3.05E-44 0.549772987 p.(S35_V37del) 0.718557539 8.71E-48 0.472341465 p.(K36_H38del) 0.347828381 1.57E-09 0.769869958 p.(V37_T39del) 0.765368446 0 0.51047201 p.(H38_R40del) 0.814016606 0 1.560856799 p.(T39_Q41del) 0.366703169 2.44E-59 0.418723286 p.(V4_T6del) 0.385029513 1.28E-08 0.306414881 p.(R40_Q42del) 0.413448408 5.55E-17 1.089165395 p.(Q41_C43del) 0.126021174 9.56E-09 0.37405105 p.(Q42_R44del) 0.662698606 0 1.1825513 p.(C43_S45del) 0.370511156 1.77E-09 2.667150465 p.(R44_R46del) 0.403336603 1.61E-06 -3.947971336 p.(S45_F47del) 0.746355505 0 -3.910994 p.(R46_V48del) 0.802903077 6.66E-52 -3.227319254 p.(F47_K49del) 0.478774591 3.65E-09 -5.587403777 p.(R5_N7del) 0.324674714 8.66E-35 -0.470227815 p.(T6_R8del) 0.884992987 1.97E-30 -0.572805096 p.(N7_Y9del) 0.63557039 1.11E-16 2.104111446 p.(R8_S10del) 0.590770775 0 0.98265217 p.(Y9_I11del) 0.593398293 5.78E-11 1.576991039 p.(K49del) 0.726744222 3.55E-59 -1.109714219 p.(K50del) 0.875154252 2.79E-108 -0.475078496 p.(D51del) 0.719767259 6.94E-07 -3.346419565 p.(G52del) 0.660990519 7.35E-11 -3.896646569 p.(H53del) 0.561792876 1.49E-11 -3.902254114 p.(C54del) 0.867014381 1.56E-25 -3.032404917 p.(N55del) 2.091173599 0 -1.655429666 p.(V56del) 0.5041387 1.98E-50 -0.978470376 p.(Q57del) 0.138418009 3.46E-22 0.499509225 p.(F58del) 0.636628722 2.22E-16 2.122616713 p.(I59del) 0.619979329 2.22E-16 1.782488602 p.(N60del) 0.339933226 9.11E-26 1.603527995 p.(V61del) 0.475174494 1.77E-07 1.858178786 p.(G62del) 0.510123075 1.22E-18 1.180235653 p.(E63del) 0.535494855 0.005036258 2.718385527 p.(K64del) 0.399426408 2.56E-28 0.061501975 p.(G65del) 0.412716521 1.00E-09 1.495092533 p.(Q66del) 0.099675456 1.01E-135 2.157652584 p.(R67del) 0.347977421 4.86E-15 0.653607771 p.(Y68del) 0.512056141 1.70E-34 0.963452917 p.(L69del) 0.50829095 2.02E-31 0.48344204 p.(A70del) 0.483344096 2.75E-77 0.416292332 p.(D71del) 0.844221253 3.01E-95 -0.025891905 p.(I72del) 0.67624809 0 2.170009905 p.(F73del) 0.279175949 0 1.541174204 p.(T74del) 0.563262641 3.33E-16 1.763568028 p.(T75del) 0.567157703 1.79E-39 0.45244701 p.(C76del) 0.532576059 3.33E-16 0.557456393 p.(V77del) 0.200731745 4.30E-05 1.476290688 p.(D78del) 0.44690002 6.95E-09 1.909516013 p.(I79del) 0.690420276 2.51E-08 5.639353623 p.(R80del) 1.089894646 1.33E-15 2.197312114 p.(W81del) 0.650037891 4.69E-55 0.279919667 p.(R82del) 0.891134484 2.52E-28 -0.78283315 p.(W83del) 0.547098547 5.05E-49 3.006014291 p.(M84del) 0.944378178 0 3.405766884 p.(L85del) 0.961419591 1.33E-15 2.721898282 p.(V86del) 0.77009331 6.07E-06 2.467887743 p.(I87del) 0.322907049 0.000117147 3.80110645 p.(F88del) 0.68697395 7.61E-64 2.644238249 p.(C89del) 0.708082337 0 2.664153106 p.(L90del) 0.7460311 0 2.411478521 p.(A91del) 0.529671735 0 3.318322554 p.(F92del) 0.474621294 1.07E-77 0.707381517 p.(V93del) 0.520398818 1.94E-07 0.770680712 p.(L94del) 0.628417142 8.65E-12 0.059797523 p.(S95del) 0.628646978 0.001985515 0.688257476 p.(W96del) 0.976587766 2.32E-23 0.190291422 p.(L97del) 0.572702747 0.002680625 -3.360936563 p.(F98del) 0.249761643 2.72E-111 -3.305352402 p.(K49_K50del) 0.432175747 2.62E-06 -5.198738299 p.(K50_D51del) 0.800524649 7.76E-46 -2.396875494 p.(D51_G52del) 1.23187654 0 -3.102884048 p.(G52_H53del) 1.060141349 0 -3.757702439 p.(H53_C54del) 0.434930144 0.001198084 -1.01983096 p.(C54_N55del) 0.702249113 8.64E-71 -1.113321432 p.(N55_V56del) 0.832473662 3.20E-49 -0.948821445 p.(V56_Q57del) 0.378684069 0 2.387786095 p.(Q57_F58del) 1.071669573 0 1.46662556 p.(F58_I59del) 0.715738692 4.44E-16 3.431473418 p.(I59_N60del) 1.284655584 0 4.195027169 p.(N60_V61del) 1.523664972 0 3.64160869 p.(V61_G62del) 0.453687602 0.001517376 3.233750621 p.(G62_E63del) 0.794522789 0 3.26602819 p.(E63_K64del) 0.596718152 2.22E-16 1.75624016 p.(K64_G65del) 0.108532686 8.57E-34 0.086564759 p.(G65_Q66del) 0.318847096 1.05E-07 2.438687916 p.(Q66_R67del) 0.454121099 1.04E-18 1.386491366 p.(R67_Y68del) 0.378071555 1.20E-10 0.789990849 p.(Y68_L69del) 0.460031307 2.08E-13 1.120647208 p.(L69_A70del) 0.377331358 0 0.937891568 p.(A70_D71del) 1.315517459 4.72E-56 0.145567874 p.(D71_I72del) 0.742379781 0.000195919 1.067013081 p.(I72_F73del) 0.511415484 9.25E-71 2.527542973 p.(F73_T74del) 0.737294369 0 3.604570617 p.(T74_T75del) 0.4632195 1.01E-11 2.591711463 p.(T75_C76del) 0.84359875 4.44E-16 3.718631545 p.(C76_V77del) 0.820136162 1.39E-08 2.373426165 p.(V77_D78del) 0.546049072 4.06E-41 2.484278354 p.(D78_I79del) 0.525330201 1.12E-42 1.758353272 p.(I79_R80del) 0.237107166 1.87E-25 4.721903044 p.(R80_W81del) 0.165043887 6.43E-47 2.782578819 p.(R82_W83del) 0.347977693 1.11E-16 -1.049331594 p.(W83_M84del) 0.415144967 1.82E-13 1.480278742 p.(M84_L85del) 0.67703191 2.45E-10 0.83698909 p.(L85_V86del) 0.770328958 0 4.139627752 p.(V86_I87del) 0.893572894 0 3.798351254 p.(I87_F88del) 0.450525824 3.54E-61 2.452722446 p.(F88_C89del) 0.370414737 1.40E-20 4.007470548 p.(C89_L90del) 0.37252872 1.89E-05 2.917965678 p.(L90_A91del) 0.615706406 0 1.641793674 p.(A91_F92del) 0.386355871 2.82E-36 4.160025272 p.(F92_V93del) 0.865652484 0 2.371057599 p.(V93_L94del) 0.350159517 6.39E-54 2.437390312 p.(L94_S95del) 2.30660614 0 -1.909495852 p.(S95_W96del) 0.886292177 2.45E-54 -3.088263299 p.(W96_L97del) 0.582940244 9.67E-20 -4.227183192 p.(L97_F98del) 0.998816938 6.66E-16 -3.343680004 p.(F98_F99del) 0.669210848 1.42E-49 -3.289125332 p.(K49_D51del) 0.815643701 9.96E-06 -3.964385099 p.(K50_G52del) 0.98565904 0 -2.636142609 p.(D51_H53del) 0.513179122 2.86E-32 -3.994639089 p.(G52_C54del) 0.760514712 2.46E-06 -3.152063138 p.(H53_N55del) 0.883722065 6.82E-54 -2.983139935 p.(C54_V56del) 0.704435355 0.001274613 -3.384783021 p.(N55_Q57del) 0.723985989 1.00E-37 -3.353561532 p.(V56_F58del) 0.187557201 1.03E-45 1.392682298 p.(Q57_I59del) 0.348306713 0.000997449 2.356436074 p.(F58_N60del) 0.398881647 9.35E-37 3.281978736 p.(I59_V61del) 0.394580688 0 3.958779802 p.(N60_G62del) 0.685149746 0 2.794308974 p.(V61_E63del) 0.454506221 1.63E-52 3.714031367 p.(G62_K64del) 0.81814278 0 3.361587275 p.(E63_G65del) 0.524696534 1.02E-06 2.295127129 p.(K64_Q66del) 0.385299488 4.37E-20 1.121586635 p.(G65_R67del) 0.434429546 3.58E-50 0.910713272 p.(Q66_Y68del) 0.370327446 7.77E-56 0.614560783 p.(R67_L69del) 0.262501427 1.94E-71 0.768279739 p.(Y68_A70del) 0.311475812 2.42E-08 1.263139463 p.(L69_D71del) 0.622155384 1.30E-33 0.657122465 p.(A70_I72del) 0.409303314 1.28E-64 1.251774771 p.(D71_F73del) 0.388040958 1.34E-16 3.536346781 p.(I72_T74del) 0.579253811 3.79E-12 2.929969992 p.(F73_T75del) 0.405498098 2.67E-58 0.541846472 p.(T74_C76del) 0.194190454 9.38E-23 1.186350778 p.(T75_V77del) 0.438870025 5.55E-17 1.950705021 p.(C76_D78del) 0.305054033 9.38E-79 1.578127 p.(V77_I79del) 0.225841373 1.05E-15 1.946330061 p.(D78_R80del) 0.731415699 0.001677095 1.297792512 p.(I79_W81del) 0.990500193 1.63E-37 -0.628219262 p.(R80_R82del) 0.970028303 1.30E-07 -2.151181024 p.(W81_W83del) 0.437635603 3.58E-35 1.172111248 p.(R82_M84del) 0.038913263 9.26E-22 2.306587444 p.(W83_L85del) 1.037846001 3.62E-68 -1.735003988 p.(M84_V86del) 0.531096298 7.22E-56 -2.467426112 p.(L85_I87del) 0.765226514 6.59E-35 -2.012909144 p.(V86_F88del) 0.807533728 1.98E-38 -0.266484222 p.(I87_C89del) 1.004284772 7.97E-38 -0.094919782 p.(F88_L90del) 0.763479004 9.62E-07 -0.721559443 p.(C89_A91del) 0.884284367 6.02E-31 -0.390098514 p.(L90_F92del) 0.531570816 7.01E-12 1.410164063 p.(A91_V93del) 0.394752643 0 1.108613406 p.(F92_L94del) 0.49406302 2.91E-57 0.730078778 p.(V93_S95del) 0.932895288 6.78E-70 -1.331829907 p.(L94_W96del) 0.691122575 3.50E-27 -3.733985566 p.(S95_L97del) 0.879586546 9.74E-33 -1.710165016 p.(W96_F98del) 0.758797478 3.41E-10 -4.024035543 p.(L97_F99del) 1.129766774 1.33E-15 -3.097475794 p.(F98_G100del) 0.739893213 4.96E-55 -3.852192295 p.(G100del) 0.90483692 8.34E-49 -2.864632026 p.(C101del) 0.971333347 2.60E-90 -2.773005493 p.(V102del) 0.892976946 5.23E-07 -1.761629559 p.(F103del) 1.069017401 1.47E-11 -2.006399439 p.(W104del) 0.898236001 2.33E-10 -4.665959945 p.(L105del) 0.7407105 3.57E-16 -3.904892289 p.(I106del) 0.734797339 9.83E-44 -3.613705686 p.(A107del) 0.896565618 6.85E-39 -2.705868956 p.(L108del) 0.66700351 6.13E-87 -2.050287416 p.(H110del) 1.73802469 8.88E-16 -4.105241719 p.(G111del) 0.79173803 1.26E-08 -3.771511843 p.(D112del) 0.964591622 6.80E-26 -2.510606757 p.(L113del) 0.727828919 0.000435563 -2.485402277 p.(D114del) 0.590256777 2.09E-22 -1.832635598 p.(T115del) 0.720551941 1.62E-33 -0.572437373 p.(D116del) 0.558953809 2.22E-16 0.970583067 p.(Y117del) 0.567337528 4.61E-79 -4.179640402 p.(K118del) 1.378160385 0 -3.674103495 p.(D119del) 0.295210322 3.61E-25 -3.913442546 p.(D120del) 0.619390913 4.02E-08 -4.829146948 p.(D121del) 1.804671602 0 -3.360503915 p.(D122del) 0.525133565 2.23E-27 -4.782320687 p.(K123del) 0.915911749 3.22E-13 -3.816589006 p.(S124del) 0.53637365 2.93E-34 -0.895229499 p.(K125del) 0.486362454 0 1.000540141 p.(V126del) 1.325932358 4.45E-53 0.608699468 p.(S127del) 0.6362691 3.05E-69 -0.516069789 p.(K128del) 0.828470979 6.66E-16 0.594203915 p.(A129del) 0.489876719 1.08E-76 -0.034884657 p.(C130del) 1.122507959 3.88E-37 -2.850421073 p.(V131del) 0.990159606 2.32E-42 -2.799467776 p.(S132del) 0.848054858 6.34E-12 -2.940135261 p.(E133del) 0.847477723 3.39E-58 -2.734177357 p.(V134del) 0.468614799 1.01E-07 -4.703546301 p.(N135del) 1.042560209 0 -4.817314354 p.(S136del) 0.941204558 3.30E-09 -2.584242383 p.(F137del) 2.099303306 0 -1.503090081 p.(T138del) 0.5950457 7.88E-08 -4.792749627 p.(A139del) 0.582313599 0.000781038 -3.553082164 p.(A140del) 1.017736009 4.44E-15 -2.714280853 p.(F141del) 0.714645094 5.96E-09 -3.667769876 p.(L142del) 0.829281487 2.14E-35 -3.401354467 p.(F143del) 0.833720187 5.29E-11 -3.802615571 p.(S144del) 0.701215709 8.30E-44 -3.480032704 p.(I145del) 0.719330689 1.38E-41 -3.807944496 p.(E146del) 0.777307459 1.82E-39 -1.175225428 p.(T147del) 0.350618506 3.17E-34 -1.40422148 p.(F99del) 1.827774051 2.66E-15 -2.656339739 p.(G100_C101del) 0.786526107 3.33E-15 -4.827124978 p.(C101_V102del) 1.641953564 0 -3.050733313 p.(V102_F103del) 0.684649491 3.21E-29 -3.832768246 p.(F103_W104del) 0.548192603 6.00E-18 -3.898097006 p.(W104_L105del) 1.173088919 4.44E-16 -3.753694703 p.(L105_I106del) 0.954799989 4.20E-45 -2.039128489 p.(I106_A107del) 1.351632644 2.40E-35 -1.916793673 p.(A107_L108del) 0.971652248 2.24E-50 -2.421391112 p.(L108_L109del) 1.512930205 2.59E-10 -1.96697643 p.(L109_H110del) 1.793189559 2.15E-13 -3.007087307 p.(H110_G111del) 1.017330151 4.44E-16 -3.019982781 p.(G111_D112del) 0.913480016 4.53E-59 -2.986581244 p.(D112_L113del) 0.349831754 1.30E-66 -3.801507383 p.(L113_D114del) 0.558100371 1.70E-22 -3.235571873 p.(D114_T115del) 0.443127981 1.55E-06 -3.961862516 p.(T115_D116del) 0.603993024 8.20E-09 -3.485076977 p.(D116_Y117del) 0.937810707 1.31E-14 -4.425374302 p.(Y117_K118del) 0.517826924 3.93E-200 -4.304140245 p.(K118_D119del) 0.525747844 1.38E-41 -4.530700858 p.(D119_D120del) 0.798594715 1.58E-34 -1.269178267 p.(D121_D122del) 0.495890372 0 -0.958112801 p.(D122_K123del) 0.894974809 2.22E-16 -1.921812312 p.(K123_S124del) 0.263044186 0.022547404 -1.314162757 p.(S124_K125del) 0.477389548 0.000167363 0.301506952 p.(K125_V126del) 0.485923268 1.11E-16 1.018625497 p.(V126_S127del) 0.687716745 1.11E-16 1.256839226 p.(S127_K128del) 0.507413068 1.67E-16 1.335443366 p.(K128_A129del) 0.409778052 7.46E-33 0.588974617 p.(A129_C130del) 0.948006708 5.42E-10 -4.624944138 p.(C130_V131del) 0.92246996 8.64E-09 -2.998914984 p.(V131_S132del) 0.628032954 1.80E-22 -3.955102795 p.(S132_E133del) 1.335782274 0 -2.756974843 p.(E133_V134del) 0.719140386 5.65E-86 -3.44854763 p.(V134_N135del) 0.937902932 4.44E-16 -3.808346981 p.(N135_S136del) 0.584467196 4.87E-14 -4.214034856 p.(S136_F137del) 1.315578692 0 -2.845331537 p.(F137_T138del) 0.607603299 1.06E-12 -3.551368562 p.(T138_A139del) 1.489308734 1.78E-15 -2.264412555 p.(A139_A140del) 1.309863299 0 -4.184794816 p.(A140_F141del) 0.756426068 2.19E-07 -4.077152819 p.(F141_L142del) 0.669301163 1.68E-11 -3.897408301 p.(L142_F143del) 1.540211884 3.58E-06 -2.348729893 p.(F143_S144del) 0.798558011 6.21E-76 -2.287868288 p.(S144_I145del) 0.730918947 1.94E-17 -3.418405548 p.(I145_E146del) 2.173026555 0 -3.604980963 p.(E146_T147del) 0.885736148 1.56E-26 -0.926470117 p.(T147_Q148del) 0.445687966 3.34E-41 -1.93490365 p.(F99_G100del) 0.566193369 2.43E-16 -3.622954718 p.(G100_V102del) 0.613565662 9.81E-49 -3.995102977 p.(C101_F103del) 1.054273348 4.44E-16 -3.752855775 p.(V102_W104del) 0.614251584 7.38E-108 -3.56736091 p.(F103_L105del) 0.674022122 3.37E-06 -2.948536291 p.(W104_I106del) 0.683891937 8.73E-27 -3.029059312 p.(L105_A107del) 1.071663322 3.35E-07 -1.646586843 p.(A107_L109del) 0.968684564 1.13E-13 -1.047207413 p.(L108_H110del) 0.63774747 9.11E-61 -2.205069913 p.(L109_G111del) 0.7435182 6.31E-14 -3.527935229 p.(H110_D112del) 0.817318449 9.29E-27 -3.656595864 p.(G111_L113del) 1.06159293 0 -3.615066457 p.(D112_D114del) 0.50118818 0.000688801 -4.194354059 p.(L113_T115del) 0.859513621 0 -3.897989169 p.(D114_D116del) 1.13230857 0 -3.245468192 p.(T115_Y117del) 0.966948512 1.78E-14 -4.499664354 p.(D116_K118del) 0.702839482 1.06E-25 -3.78813092 p.(Y117_D119del) 0.56957072 3.36E-07 -3.887587163 p.(K118_D120del) 0.448017019 0.001729933 -4.664144483 p.(D119_D121del) 0.556833011 1.12E-21 -4.13941954 p.(D121_K123del) 0.535084064 4.02E-07 -4.119888619 p.(D122_S124del) 0.631554466 0.006335857 -4.327300331 p.(K123_K125del) 0.560514928 1.46E-13 -3.448855246 p.(S124_V126del) 0.718133672 0.000226198 -3.736422573 p.(S127_A129del) 0.805846961 1.75E-07 -3.42698266 p.(K128_C130del) 1.57671537 1.36E-56 -2.543461979 p.(A129_V131del) 1.582566208 1.21E-44 -0.007914377 p.(C130_S132del) 1.082124862 3.31E-12 -1.389272298 p.(V131_E133del) 1.500542345 1.78E-15 -3.474042492 p.(S132_V134del) 1.37412186 1.33E-15 -2.643113382 p.(E133_N135del) 0.671102315 1.17E-37 -3.780619813 p.(V134_S136del) 0.846721901 2.06E-05 -2.982752304 p.(N135_F137del) 0.77359711 3.43E-05 -4.037810436 p.(S136_T138del) 0.98065579 1.52E-92 -2.572622567 p.(F137_A139del) 1.670208459 0 -3.471795531 p.(T138_A140del) 0.710103485 5.35E-05 -4.411784871 p.(A139_F141del) 0.84972698 5.88E-15 -3.641437679 p.(A140_L142del) 0.963639563 2.54E-05 -3.439790215 p.(F141_F143del) 1.356948525 6.30E-45 -2.005365415 p.(L142_S144del) 0.764941284 6.78E-13 -1.848085693 p.(F143_I145del) 0.477736907 4.40E-28 -4.358827202 p.(S144_E146del) 0.890371509 1.22E-16 -2.765246312 p.(I145_T147del) 0.987814241 6.35E-15 -2.351875836 p.(E146_Q148del) 0.922297915 1.63E-29 -2.8775135 p.(T147_T149del) 0.636376747 2.74E-50 -4.021643217 p.(F99_C101del) 0.897292148 7.37E-05 -3.891180115 p.(Q148del) 1.05717634 1.58E-32 -1.128376316 p.(T149del) 0.306081559 1.75E-42 0.544457708 p.(T150del) 0.162147553 3.19E-51 -0.101834665 p.(I151del) 0.601199199 2.22E-16 0.522933432 p.(G152del) 0.675530629 1.11E-46 -1.011697919 p.(Y153del) 0.83253457 1.12E-13 1.05382412 p.(G154del) 1.222589061 1.30E-28 -2.371958932 p.(F155del) 1.034446473 1.64E-05 -1.296504071 p.(R156del) 1.049442834 0.000241008 -2.75826584 p.(C157del) 0.368569136 5.16E-50 0.82036518 p.(V158del) 0.831585658 5.62E-07 -0.839576606 p.(T159del) 1.073017406 7.89E-38 -1.112931534 p.(D160del) 1.876073995 3.22E-13 -0.576510517 p.(E161del) 1.024543545 8.44E-27 -2.005168448 p.(C162del) 0.86517871 4.98E-39 -3.142210014 p.(P163del) 0.772400069 2.94E-41 -3.640913477 p.(I164del) 0.803936097 9.15E-08 -3.755353209 p.(A165del) 0.87980529 3.02E-11 -3.431539593 p.(V166del) 0.764602551 1.82E-36 -3.333865226 p.(F167del) 0.983043771 1.44E-13 -3.303307853 p.(M168del) 1.050692695 1.78E-15 -3.90053916 p.(V169del) 0.813412373 5.11E-84 -2.569223218 p.(V170del) 1.495036341 0 -2.087745806 p.(F171del) 1.109413827 0 -3.86957368 p.(Q172del) 1.705853676 1.78E-15 -3.843949339 p.(S173del) 0.7182594 3.11E-38 -2.258160627 p.(I174del) 0.603214641 9.78E-07 -4.428830099 p.(V175del) 0.431913121 2.19E-29 -4.284092157 p.(G176del) 1.429925449 8.88E-16 -4.640494784 p.(C177del) 0.695321377 0.000805829 -2.711660297 p.(I178del) 0.843366838 2.54E-52 -3.271763698 p.(I179del) 0.867607711 7.13E-12 -3.135442045 p.(D180del) 0.587249256 0.005028615 -3.123657274 p.(A181del) 0.474911905 1.11E-16 -0.936239399 p.(F182del) 1.648618948 8.88E-16 -2.740377803 p.(I183del) 0.739394973 3.33E-16 -4.571890494 p.(I184del) 1.399054637 1.78E-15 -2.210208246 p.(G185del) 0.363295852 6.27E-09 1.707398869 p.(A186del) 1.101765991 0 -0.556792826 p.(V187del) 0.433481052 5.06E-27 1.256556254 p.(M188del) 0.652898332 8.71E-78 -0.464743636 p.(A189del) 0.217463202 1.60E-14 0.832637518 p.(K190del) 0.909661724 9.36E-25 -0.635641703 p.(M191del) 0.806010518 2.73E-15 -0.830078113 p.(A192del) 1.00614986 1.62E-44 -0.544721083 p.(K193del) 0.667262547 3.01E-30 -0.936884971 p.(P194del) 0.850801843 4.80E-79 -0.212789573 p.(K195del) 0.141952005 4.71E-14 0.363319108 p.(Q148_T149del) 0.72626124 4.74E-19 -1.604497378 p.(T149_T150del) 1.159643625 1.27E-72 -0.207981123 p.(T150_I151del) 1.09942214 3.27E-56 0.323051604 p.(I151_G152del) 0.903210417 8.83E-07 -1.620822647 p.(G152_Y153del) 0.911822018 5.43E-103 -2.563735296 p.(Y153_G154del) 1.291365926 2.23E-48 -1.791548665 p.(G154_F155del) 0.910423168 6.09E-95 -2.100685271 p.(F155_R156del) 0.666046835 1.13E-91 -1.892037384 p.(R156_C157del) 0.905636088 3.34E-29 -0.307606008 p.(C157_V158del) 1.192195421 7.04E-12 -3.596290608 p.(V158_T159del) 1.09263776 0.000102606 -3.253434249 p.(T159_D160del) 1.394631777 5.61E-83 -1.750991668 p.(D160_E161del) 0.998541928 1.90E-63 -1.921863939 p.(E161_C162del) 0.446234101 3.11E-35 -3.790011198 p.(C162_P163del) 0.833029495 1.32E-17 -3.165394798 p.(P163_I164del) 0.985513062 9.17E-13 -3.79881689 p.(I164_A165del) 0.913114667 2.84E-12 -3.169878792 p.(A165_V166del) 0.649625796 1.97E-16 -3.234352385 p.(V166_F167del) 0.742529736 1.32E-10 -3.737474788 p.(F167_M168del) 0.585212666 2.82E-38 -3.645906706 p.(M168_V169del) 1.115437993 1.33E-15 -3.656019421 p.(V169_V170del) 0.664184069 0.000415445 -3.288495875 p.(V170_F171del) 1.081602005 0 -4.531315031 p.(F171_Q172del) 0.773544404 1.59E-07 -3.545810404 p.(Q172_S173del) 0.655990564 1.48E-23 -3.685619261 p.(S173_I174del) 0.662661007 8.49E-21 -4.046522105 p.(I174_V175del) 0.726274442 1.09E-20 -3.780837426 p.(V175_G176del) 0.699688929 3.93E-11 -3.189692458 p.(G176_C177del) 1.340725082 0 -4.428057444 p.(C177_I178del) 0.894464729 7.89E-39 -2.960732053 p.(I178_I179del) 0.375130558 1.83E-38 -4.626240354 p.(I179_D180del) 0.743032957 5.99E-32 -2.996040984 p.(D180_A181del) 0.864636905 0.0002504 -3.514716927 p.(A181_F182del) 0.336157685 0.003483604 -5.01133541 p.(F182_I183del) 0.892546583 3.73E-12 -3.856422911 p.(I183_I184del) 1.581191073 0 -3.953414782 p.(I184_G185del) 0.309793884 0.002336772 -5.179108377 p.(G185_A186del) 1.477778635 1.78E-15 -3.584945921 p.(A186_V187del) 0.495664092 1.12E-28 -4.210269809 p.(V187_M188del) 0.604924838 1.76E-45 -3.092725044 p.(M188_A189del) 1.361505162 1.78E-15 -2.289699145 p.(A189_K190del) 0.534154092 7.97E-29 0.681113773 p.(K190_M191del) 0.980729987 2.29E-59 0.315038266 p.(M191_A192del) 0.542615661 2.79E-41 -0.130235214 p.(A192_K193del) 0.825709482 2.57E-87 -0.929193974 p.(K193_P194del) 0.649496106 3.23E-18 -0.219954713 p.(P194_K195del) 0.456461574 4.40E-138 -0.095308474 p.(K195_K196del) 0.706478539 1.85E-32 -0.06694701 p.(K196_R197del) 0.662315873 8.07E-46 0.138694517 p.(Q148_T150del) 0.772868604 1.63E-12 -3.440692937 p.(T149_I151del) 0.64447701 1.05E-57 -1.339167753 p.(T150_G152del) 1.190186734 1.33E-15 -2.725600711 p.(I151_Y153del) 0.790630198 3.69E-31 -0.915720927 p.(G152_G154del) 1.112531472 5.56E-11 -1.921879752 p.(Y153_F155del) 1.140599109 7.25E-61 -2.108991808 p.(G154_R156del) 1.830406776 0 0.204488227 p.(F155_C157del) 0.837567433 8.06E-42 0.528526011 p.(R156_V158del) 1.283426935 5.72E-73 -1.805511235 p.(C157_T159del) 1.522928487 0.003423812 -1.030696839 p.(V158_D160del) 1.131828506 5.14E-54 -2.404723955 p.(T159_E161del) 0.838815118 2.02E-30 -3.430818375 p.(D160_C162del) 0.861268344 2.15E-54 -1.809165267 p.(E161_P163del) 2.541839445 0 -5.937703976 p.(C162_I164del) 1.188457344 2.69E-44 -1.797089699 p.(P163_A165del) 0.914076126 8.92E-05 -3.279118674 p.(I164_V166del) 0.779433098 8.34E-08 -2.874188196 p.(A165_F167del) 0.595795921 0.0005444 -4.186611209 p.(V166_M168del) 0.749600502 0.002627701 -4.091231623 p.(M168_V170del) 0.740813629 5.06E-08 -3.315045744 p.(V169_F171del) 0.713442239 1.61E-08 -3.590065381 p.(V170_Q172del) 0.789661501 1.18E-06 -4.038737189 p.(F171_S173del) 0.653951009 1.54E-06 -2.333324678 p.(Q172_I174del) 1.029304832 0 -2.938237497 p.(S173_V175del) 0.895799748 6.66E-16 -3.65319211 p.(I174_G176del) 0.808224433 9.16E-48 -3.414912125 p.(V175_C177del) 0.642272902 1.87E-05 -4.390349413 p.(G176_I178del) 0.581038564 4.09E-32 -3.275238457 p.(C177_I179del) 0.82054631 1.20E-51 -3.187002031 p.(I178_D180del) 0.721394254 0.002828806 -3.706619458 p.(I179_A181del) 0.615187426 1.06E-08 -3.075857766 p.(D180_F182del) 0.604608846 1.27E-42 -4.0217399 p.(A181_I183del) 0.610431373 4.77E-52 -3.841986327 p.(F182_I184del) 0.448379611 4.07E-46 -4.128765117 p.(I183_G185del) 0.642213534 1.31E-27 -3.941982016 p.(I184_A186del) 0.795930003 1.28E-08 -4.174475963 p.(G185_V187del) 2.075600355 3.55E-15 -3.02846936 p.(A186_M188del) 0.889267796 8.80E-11 -3.435394585 p.(V187_A189del) 0.839718528 0.002215698 -2.690632908 p.(M188_K190del) 0.999355436 7.58E-134 -0.454165563 p.(K190_A192del) 0.740918964 1.32E-33 -0.398472408 p.(M191_K193del) 0.988792539 1.34E-29 -0.547553647 p.(A192_P194del) 0.465045038 3.06E-30 -0.862360977 p.(K193_K195del) 1.060021706 7.40E-49 -0.629700355 p.(P194_K196del) 0.88241059 2.28E-20 -0.594214926 p.(K195_R197del) 1.112056663 0 -0.827557729 p.(R197del) 0.494800175 0 0.336935066 p.(N198del) 0.544322239 0 1.921239677 p.(E199del) 0.49716519 1.67E-16 0.998267481 p.(T200del) 0.703813805 0 0.899193066 p.(L201del) 0.367246531 2.39E-10 1.46693419 p.(V202del) 0.338022456 7.39E-14 0.549468652 p.(F203del) 0.689568257 1.92E-08 -2.263522169 p.(S204del) 0.686335793 4.70E-24 -3.592654142 p.(H205del) 0.604323526 7.52E-23 -3.863144392 p.(N206del) 0.47081151 1.47E-10 -4.289717552 p.(A207del) 0.485452145 1.62E-13 -3.571364275 p.(V208del) 0.809333232 0.004709566 -3.744175027 p.(I209del) 0.770539153 5.85E-14 -2.491683131 p.(A210del) 0.791410031 3.94E-26 -2.975456158 p.(M211del) 0.659937488 4.51E-56 -3.612226064 p.(R212del) 0.684228916 2.86E-06 -2.676264579 p.(D213del) 0.793963174 7.56E-11 -4.65956904 p.(G214del) 1.202389022 0 -3.106426336 p.(K215del) 0.614173433 0 -5.214588524 p.(L216del) 1.124463999 0 -4.530249338 p.(C217del) 0.776366169 2.32E-08 -2.741493734 p.(L218del) 0.945507587 4.44E-16 -3.233746936 p.(M219del) 0.60905449 0.00384121 -4.34982893 p.(W220del) 0.823059667 4.98E-78 -2.777884398 p.(R221del) 1.111563882 1.37E-10 -4.009809976 p.(V222del) 1.116495482 2.45E-07 -3.125884477 p.(G223del) 0.499102583 7.40E-22 -0.183648264 p.(N224del) 0.646943017 2.18E-30 0.264368257 p.(L225del) 0.463426404 6.23E-10 1.210620035 p.(R226del) 0.660108352 1.51E-86 -0.056554765 p.(K227del) 0.489343497 2.22E-16 0.517412719 p.(S228del) 0.548804645 2.97E-44 0.319228716 p.(H229del) 0.444831077 1.38E-46 0.639113046 p.(L230del) 0.845590729 1.52E-81 -0.650901061 p.(V231del) 0.173866583 7.61E-07 0.682089858 p.(E232del) 0.356221374 7.14E-90 0.416413597 p.(A233del) 0.337850839 2.66E-65 0.074792069 p.(H234del) 0.80973097 3.84E-54 -0.641120893 p.(V235del) 1.481023479 1.54E-10 -3.165157113 p.(R236del) 0.715681398 5.95E-20 -3.921439105 p.(A237del) 0.789700454 1.04E-12 -2.550316398 p.(Q238del) 0.50184348 1.46E-46 -3.421118822 p.(L239del) 0.728122892 1.14E-63 -3.403556381 p.(K241del) 1.033890928 7.52E-33 -0.456944917 p.(S242del) 0.297818863 1.21E-07 0.057192261 p.(R243del) 1.248040757 0.000267385 -0.477694971 p.(I244del) 0.503888276 0 0.639896769 p.(R197_N198del) 0.436710395 2.04E-106 -0.280634651 p.(N198_E199del) 0.854191219 5.05E-57 -0.504465849 p.(E199_T200del) 0.936043656 2.95E-49 -0.745104271 p.(T200_L201del) 0.487755969 2.13E-29 -1.599208398 p.(L201_V202del) 0.953517308 3.36E-18 -2.957657522 p.(V202_F203del) 0.864978783 1.16E-09 -2.875527219 p.(F203_S204del) 0.739754807 2.04E-104 -2.98373124 p.(S204_H205del) 1.160352399 0 -3.224715933 p.(H205_N206del) 0.655291599 4.86E-06 -4.50471353 p.(N206_A207del) 0.68591778 0.000681281 -3.266593089 p.(A207_V208del) 1.074285712 0 -3.97833927 p.(V208_I209del) 0.92576477 4.15E-21 -2.804141952 p.(I209_A210del) 0.791152325 7.49E-48 -2.685348085 p.(A210_M211del) 0.790218767 1.66E-10 -3.234700995 p.(M211_R212del) 0.454227724 4.91E-34 -2.988387372 p.(R212_D213del) 0.942323304 4.44E-16 -4.174511926 p.(D213_G214del) 0.757163209 1.47E-118 -3.074059018 p.(G214_K215del) 0.779639268 1.43E-40 -2.756316713 p.(K215_L216del) 0.477737339 3.01E-107 -3.812048008 p.(L216_C217del) 0.452543566 6.95E-07 -3.462841013 p.(C217_L218del) 0.491158578 2.33E-06 -4.252460492 p.(L218_M219del) 0.520422566 2.57E-06 -3.837305416 p.(M219_W220del) 0.795450742 3.13E-49 -3.235227741 p.(W220_R221del) 1.515963854 0 -4.731003957 p.(R221_V222del) 1.277690665 8.88E-16 -4.018369468 p.(V222_G223del) 0.694096658 0.005192231 -3.655380048 p.(G223_N224del) 0.608403141 1.35E-50 -1.03006127 p.(N224_L225del) 1.162965808 2.83E-62 -0.119735126 p.(L225_R226del) 0.354576701 2.13E-17 0.733637801 p.(R226_K227del) 0.982956005 1.06E-21 -0.416394827 p.(K227_S228del) 0.994583619 7.98E-85 0.62639296 p.(S228_H229del) 1.280975319 4.34E-32 -1.384770585 p.(H229_L230del) 0.814117348 1.30E-20 -0.431213812 p.(L230_V231del) 0.932805988 9.44E-14 -0.008505611 p.(V231_E232del) 0.401838486 9.68E-62 0.03516283 p.(E232_A233del) 0.494316281 6.06E-49 1.210331186 p.(A233_H234del) 0.446525467 2.65E-08 0.555035644 p.(H234_V235del) 0.444428603 2.88E-23 0.032000478 p.(V235_R236del) 1.011426406 5.98E-37 -0.21078437 p.(R236_A237del) 1.693123595 0 -1.77336221 p.(A237_Q238del) 1.154276213 2.69E-47 -1.655402099 p.(Q238_L239del) 0.747403556 5.17E-10 -3.012449922 p.(L239_L240del) 0.597371736 4.61E-24 -3.742446936 p.(L240_K241del) 1.510968163 0 -2.369383419 p.(K241_S242del) 0.875703621 9.66E-68 -2.383144849 p.(S242_R243del) 1.087926028 7.11E-08 -2.936458383 p.(R243_I244del) 0.971646516 1.89E-07 -1.06452031 p.(I244_T245del) 0.391593265 4.13E-09 0.562099102 p.(R197_E199del) 0.770616695 1.47E-90 -0.783190153 p.(N198_T200del) 0.544789888 3.59E-39 -1.66655354 p.(E199_L201del) 0.804400702 9.13E-16 -3.227423467 p.(T200_V202del) 0.928193557 0 -3.443729666 p.(L201_F203del) 0.894488256 2.22E-16 -5.382203955 p.(V202_S204del) 0.411518795 1.07E-37 -4.0532828 p.(F203_H205del) 0.569068038 2.30E-05 -4.891003079 p.(S204_N206del) 0.369837277 9.26E-25 -4.486164776 p.(H205_A207del) 0.571101788 2.49E-50 -4.492177488 p.(N206_V208del) 0.506079487 1.12E-30 -3.986423783 p.(A207_I209del) 0.678757705 8.84E-50 -3.933456218 p.(V208_A210del) 0.611360452 2.27E-55 -3.253717234 p.(I209_M211del) 1.265482491 1.29E-14 -3.235759831 p.(A210_R212del) 0.583290942 3.71E-18 -3.395287466 p.(M211_D213del) 0.612625885 5.72E-09 -4.305584187 p.(R212_G214del) 0.617477183 0.003041475 -3.679472744 p.(D213_K215del) 0.456140111 1.63E-12 -4.700894403 p.(G214_L216del) 0.742118978 5.63E-57 -3.369384158 p.(K215_C217del) 0.665394549 8.26E-42 -3.562276126 p.(L216_L218del) 0.50754059 8.98E-23 -4.371185316 p.(C217_M219del) 1.032303176 0 -4.110481134 p.(L218_W220del) 0.915619034 4.22E-08 -3.695205387 p.(M219_R221del) 1.307142652 0 -2.543692102 p.(W220_V222del) 1.264569499 0 -3.514434354 p.(R221_G223del) 0.815844991 4.70E-35 -2.69223481 p.(V222_N224del) 0.771057937 3.79E-05 -3.667183436 p.(G223_L225del) 1.574677702 1.78E-15 -3.561265156 p.(N224_R226del) 0.888727824 0.003178103 -2.262847191 p.(L225_K227del) 1.042909474 4.06E-17 -0.49790253 p.(R226_S228del) 1.056102925 1.48E-70 -0.265786536 p.(K227_H229del) 0.897608194 1.47E-42 -0.413616777 p.(S228_L230del) 0.842666095 2.01E-95 -2.754763049 p.(H229_V231del) 1.658249044 0 -3.447200701 p.(L230_E232del) 0.763047888 2.15E-41 -0.565318841 p.(V231_A233del) 0.965099117 1.01E-79 -0.639294097 p.(E232_H234del) 0.822311929 1.22E-40 1.599618216 p.(A233_V235del) 0.773659676 1.41E-08 -3.504750756 p.(H234_R236del) 0.829904627 0 -2.85461716 p.(V235_A237del) 1.229610478 4.44E-16 -3.764176967 p.(R236_Q238del) 1.097301062 4.13E-14 -3.531029037 p.(A237_L239del) 0.533256263 4.56E-35 -4.939910959 p.(Q238_L240del) 0.799942025 1.25E-31 -3.004256954 p.(L239_K241del) 0.292442386 1.69E-21 -4.713022319 p.(L240_S242del) 0.380759857 1.27E-07 -3.789517569 p.(K241_R243del) 1.364472226 2.12E-95 -1.723351217 p.(S242_I244del) 1.45353945 0 -2.814321919 p.(R243_T245del) 0.552969682 3.34E-14 -0.430330874 p.(I244_S246del) 0.77168089 6.55E-60 -0.565754736 p.(T245del) 0.39941792 7.93E-13 0.058819671 p.(S246del) 0.272502754 3.52E-12 -0.501986823 p.(E247del) 0.966591627 7.40E-42 -0.165081392 p.(G248del) 0.690136994 1.57E-50 -0.028432757 p.(E249del) 0.301413047 5.55E-17 0.247745663 p.(Y250del) 0.457010943 3.76E-05 1.37440215 p.(I251del) 0.359821038 5.49E-05 2.1867272 p.(P252del) 0.205598794 1.62E-30 0.78240685 p.(L253del) 0.290988753 4.84E-59 -0.136010338 p.(D254del) 0.378370143 2.15E-06 1.380642827 p.(Q255del) 0.80331839 7.60E-44 -0.175031 p.(I256del) 0.945304782 3.15E-66 -0.600244426 p.(D257del) 1.507266041 3.51E-83 -1.262727364 p.(I258del) 1.108166916 0 -2.90008812 p.(N259del) 2.112337271 0 -2.617696376 p.(V260del) 0.524027695 1.80E-10 -3.766714762 p.(G261del) 0.608806609 6.98E-62 -1.18352841 p.(F262del) 0.765014622 1.53E-38 -0.225080834 p.(D263del) 0.45701494 4.19E-18 -0.007520342 p.(S264del) 0.217693374 0.006736283 0.520476084 p.(G265del) 0.448233654 0 1.126918258 p.(I266del) 0.794020467 0 0.115062506 p.(D267del) 0.466013239 2.93E-28 0.138241846 p.(R268del) 0.911987558 5.06E-31 -0.0799521 p.(I269del) 0.658200639 9.43E-39 -0.256435135 p.(F270del) 1.015520748 3.32E-23 -0.445154467 p.(L271del) 0.94280571 3.54E-55 -0.437863897 p.(V272del) 0.427115936 3.78E-62 0.12037989 p.(S273del) 0.863123039 2.97E-41 0.052754471 p.(P274del) 0.795350305 0.000963828 -3.538432128 p.(I275del) 1.054806472 6.90E-70 0.027374893 p.(T276del) 0.611882552 1.05E-48 -0.39643795 p.(I277del) 1.134353984 0 -4.097124972 p.(V278del) 0.895455993 9.53E-14 -3.116174612 p.(H279del) 0.251003792 2.26E-13 -4.674064641 p.(E280del) 0.574151466 0.000827474 -4.227060407 p.(I281del) 0.996214532 0 -3.645373926 p.(D282del) 0.576024004 7.38E-56 -4.135821753 p.(E283del) 0.742557997 1.89E-06 -3.282362106 p.(D284del) 0.730036302 2.30E-08 -2.056808126 p.(S285del) 0.94850315 4.44E-16 -3.834342444 p.(P286del) 0.651965348 1.53E-34 -3.875736122 p.(L287del) 0.595130513 5.43E-08 -3.47113282 p.(Y288del) 1.198898573 0 -2.782120984 p.(D289del) 0.803537359 4.99E-05 -4.320860845 p.(L290del) 0.525946202 1.71E-95 -3.732891892 p.(S291del) 0.822279741 1.61E-08 -3.550639839 p.(K292del) 0.694682289 0.003418595 -4.393458754 p.(T245_S246del) 0.436235231 5.55E-17 0.050892693 p.(S246_E247del) 0.693474713 6.81E-38 -1.126823802 p.(E247_G248del) 0.462101474 3.29E-101 -2.193975947 p.(G248_E249del) 0.892057488 2.37E-05 -1.170422734 p.(E249_Y250del) 0.256666519 0.00021834 0.030823641 p.(Y250_I251del) 0.555393424 8.01E-25 2.200709561 p.(I251_P252del) 0.379470631 1.11E-16 2.162599928 p.(P252_L253del) 0.470412219 0 1.640994189 p.(L253_D254del) 0.878379162 6.96E-58 -0.32731677 p.(D254_Q255del) 0.630224055 7.23E-36 -1.477828038 p.(Q255_I256del) 1.533951003 8.63E-13 -3.268634236 p.(I256_D257del) 0.977118721 0.015516356 -2.893205494 p.(D257_I258del) 1.149820613 1.68E-22 -2.402327542 p.(I258_N259del) 0.784196138 0.002799886 -2.616250971 p.(N259_V260del) 1.201660808 1.27E-21 -2.11330681 p.(V260_G261del) 1.136308039 7.64E-62 -2.239208102 p.(G261_F262del) 0.881751122 8.24E-57 0.158882399 p.(F262_D263del) 1.06750202 1.42E-21 -0.356621812 p.(D263_S264del) 0.354081684 2.20E-63 -0.50878066 p.(S264_G265del) 0.630773502 1.72E-10 1.299513112 p.(G265_I266del) 0.815706774 2.22E-16 1.304131621 p.(I266_D267del) 0.379102838 1.27E-51 0.523130762 p.(D267_R268del) 0.729238561 1.17E-204 -0.353806975 p.(R268_I269del) 0.849788315 3.22E-85 0.288459906 p.(I269_F270del) 0.613750078 7.59E-36 -0.229561495 p.(F270_L271del) 0.659339001 4.89E-65 -0.49682269 p.(L271_V272del) 0.432281528 1.88E-30 0.248645219 p.(V272_S273del) 0.393606376 8.20E-58 0.671247225 p.(S273_P274del) 0.59404941 1.28E-45 -1.451164898 p.(P274_I275del) 0.436849186 2.02E-40 0.581516554 p.(I275_T276del) 1.079359096 3.14E-201 -2.396910002 p.(I277_V278del) 0.779100357 3.38E-07 -3.334545468 p.(V278_H279del) 1.013299782 0 -3.831988743 p.(H279_E280del) 0.884945975 3.68E-82 -3.092228237 p.(E280_I281del) 0.725161814 9.83E-41 -3.832448325 p.(I281_D282del) 0.683434424 4.13E-09 -4.620844597 p.(D282_E283del) 0.778533827 1.18E-51 -3.521554844 p.(D284_S285del) 0.707550632 4.97E-79 -3.964040878 p.(S285_P286del) 0.259223482 1.56E-12 -3.786689038 p.(P286_L287del) 0.665674631 4.32E-30 -3.689447023 p.(L287_Y288del) 0.456197254 2.29E-38 -3.902558581 p.(Y288_D289del) 0.754917779 1.67E-07 -2.471955845 p.(D289_L290del) 0.75735774 2.16E-12 -3.665352358 p.(L290_S291del) 0.655000634 3.92E-31 -3.476335171 p.(S291_K292del) 0.674216071 5.76E-47 -3.28377315 p.(K292_Q293del) 0.824692947 0.00019737 -3.795351074 p.(T245_E247del) 0.513304674 2.47E-68 -1.44859368 p.(S246_G248del) 1.070211805 1.63E-14 -2.134620202 p.(E247_E249del) 1.017301653 1.71E-11 -3.540588125 p.(G248_Y250del) 0.671378789 3.67E-72 -0.687343795 p.(E249_I251del) 0.322493729 4.37E-14 0.992398631 p.(Y250_P252del) 0.155985079 8.58E-16 2.4256122 p.(I251_L253del) 0.235909801 1.90E-43 1.381826082 p.(P252_D254del) 1.070081928 4.89E-51 0.070807073 p.(L253_Q255del) 0.36691072 0 3.325128063 p.(D254_I256del) 0.520805734 1.03E-07 0.701360819 p.(I256_I258del) 1.146789793 0 -3.428043131 p.(D257_N259del) 0.633128623 1.87E-78 -2.504156145 p.(I258_V260del) 0.638576148 5.34E-21 -3.362841887 p.(N259_G261del) 1.513895298 1.09E-32 -1.554081373 p.(V260_F262del) 0.618057874 7.24E-18 -3.821795807 p.(G261_D263del) 0.849987591 1.72E-38 -0.267087007 p.(F262_S264del) 0.209641693 6.32E-07 -0.224563384 p.(D263_G265del) 0.727571296 2.89E-30 0.326672682 p.(S264_I266del) 0.240325722 5.70E-54 0.734142228 p.(G265_D267del) 0.602415597 8.75E-77 0.187788672 p.(I266_R268del) 0.254562804 4.45E-09 1.093266291 p.(D267_I269del) 0.365909455 2.54E-09 1.31102033 p.(R268_F270del) 0.333637165 1.45E-12 1.186853053 p.(I269_L271del) 0.686258896 1.50E-73 -0.944639391 p.(F270_V272del) 0.261642919 5.43E-86 0.10970322 p.(L271_S273del) 0.858892476 1.14E-84 0.226347975 p.(V272_P274del) 0.921067554 7.95E-101 -0.02865364 p.(S273_I275del) 0.65569037 1.52E-47 -0.153808044 p.(P274_T276del) 1.205913668 0 -2.100593705 p.(I275_I277del) 1.230260056 0 -3.379147174 p.(T276_V278del) 0.858859147 6.85E-06 -2.905045138 p.(I277_H279del) 0.397618039 1.83E-27 -4.460753408 p.(V278_E280del) 0.844838355 2.16E-64 -2.993315996 p.(H279_I281del) 0.664389283 1.56E-60 -3.966935213 p.(E280_D282del) 0.722585457 8.50E-37 -3.731804335 p.(I281_E283del) 1.758669353 0 -3.694044492 p.(D282_D284del) 1.003877741 1.33E-13 -3.279402719 p.(E283_S285del) 0.591889692 8.74E-08 -3.492576179 p.(D284_P286del) 0.795435302 2.53E-12 -3.274813148 p.(S285_L287del) 0.858073787 3.30E-05 -4.753699786 p.(P286_Y288del) 0.867623495 8.21E-59 -3.194427506 p.(L287_D289del) 0.927364327 1.20E-13 -2.438486165 p.(Y288_L290del) 0.823774608 2.92E-34 -3.245924988 p.(D289_S291del) 0.608328123 0.000130793 -3.781213284 p.(L290_K292del) 0.787369894 3.05E-51 -3.420762963 p.(S291_Q293del) 1.160447723 1.33E-15 -5.042830264 p.(K292_D294del) 0.615355203 3.14E-17 -4.215651138 p.(Q293del) 1.125681335 4.44E-16 -4.953473526 p.(D294del) 0.51720566 1.80E-18 -4.208709188 p.(I295del) 0.795872577 1.56E-26 -3.424436511 p.(D296del) 0.487444481 1.35E-46 -3.733667625 p.(N297del) 0.332306661 1.06E-27 -4.506229673 p.(A298del) 0.654781519 0.002635667 -3.780634621 p.(D299del) 0.582014106 5.35E-19 -3.760707 p.(F300del) 1.320958033 0 -3.920160998 p.(E301del) 0.816307341 1.15E-57 -3.405161153 p.(I302del) 0.712103675 6.41E-15 -2.856418962 p.(V303del) 0.814380375 1.34E-12 -4.775577525 p.(V304del) 0.547275934 2.10E-08 -4.281544527 p.(I305del) 0.676181657 1.81E-48 -4.271530388 p.(L306del) 0.690333671 0.001076751 -3.846278586 p.(E307del) 0.610882602 1.07E-23 -0.334390852 p.(G308del) 0.742044332 2.22E-16 0.349294193 p.(M309del) 0.224094113 2.05E-22 0.786363611 p.(V310del) 0.723198259 1.79E-20 0.810199194 p.(E311del) 0.435958243 0 -0.030354558 p.(A312del) 1.15808898 1.33E-15 -1.964632403 p.(T313del) 0.389969921 1.92E-79 1.60921398 p.(A314del) 0.305001736 1.21E-58 0.392523022 p.(M315del) 0.329968083 1.41E-62 0.686602487 p.(T316del) 0.29075429 2.78E-17 0.102779774 p.(T317del) 0.802536493 7.72E-10 0.709374484 p.(Q318del) 0.112563689 8.24E-06 0.274434605 p.(C319del) 0.326080869 4.66E-11 1.094305064 p.(R320del) 0.273650432 5.77E-19 1.596100475 p.(S321del) 0.649291081 2.22E-16 2.528604422 p.(Y323del) 0.696547593 7.48E-50 -3.873402224 p.(L324del) 0.548086397 1.75E-05 -3.384257389 p.(A325del) 0.773261843 1.67E-41 -3.603212106 p.(N326del) 0.725552861 2.04E-65 -3.376127105 p.(E327del) 1.217126554 0 -2.968001497 p.(I328del) 0.827631453 1.77E-08 -3.635995324 p.(L329del) 0.574707726 5.56E-05 -3.218057431 p.(W330del) 0.57903659 0.000978542 -4.039149903 p.(G331del) 0.650262361 1.49E-40 -3.146851445 p.(H332del) 0.660900758 1.66E-11 -4.183320575 p.(R333del) 0.665004143 9.28E-05 -4.345849753 p.(Y334del) 0.706871967 7.29E-12 -4.269665263 p.(E335del) 2.00848312 0 -4.947564538 p.(P336del) 0.583550924 1.36E-43 -3.836503472 p.(V337del) 0.681138255 3.67E-11 -1.201189101 p.(L338del) 0.945935146 1.01E-50 -1.182130977 p.(F339del) 0.575711913 1.09E-63 -0.041719573 p.(E340del) 0.747698262 0.000121578 -2.916259123 p.(Q293_D294del) 0.667067812 6.51E-10 -3.323890551 p.(D294_I295del) 0.711887541 0.005836248 -3.939343368 p.(I295_D296del) 0.801205625 0.000118642 -3.689603367 p.(D296_N297del) 1.333239735 4.44E-16 -2.877256214 p.(N297_A298del) 0.631286442 1.14E-25 -3.533926452 p.(A298_D299del) 0.690874957 1.20E-26 -3.731090247 p.(D299_F300del) 0.525399622 6.18E-38 -3.40328018 p.(F300_E301del) 0.787955934 1.11E-15 -5.0843832 p.(E301_I302del) 0.828150546 2.22E-16 -3.535330343 p.(I302_V303del) 1.352080402 1.78E-15 -3.787744695 p.(V303_V304del) 1.969320751 0 -1.354792299 p.(V304_I305del) 0.56693948 7.90E-05 -3.25615061 p.(I305_L306del) 0.719890208 2.32E-63 -0.97527821 p.(L306_E307del) 2.422026704 1.39E-59 -0.708425615 p.(E307_G308del) 0.83921226 7.79E-60 -0.134773424 p.(G308_M309del) 0.170005872 1.71E-23 -0.077871113 p.(M309_V310del) 0.611284806 2.51E-28 0.008637738 p.(V310_E311del) 0.345107937 3.57E-54 1.036210525 p.(E311_A312del) 0.677833598 1.86E-17 0.059926513 p.(A312_T313del) 0.441442462 7.42E-33 0.935503361 p.(T313_A314del) 0.253496969 2.71E-56 1.232675427 p.(A314_M315del) 0.727886917 0 0.019323601 p.(M315_T316del) 0.636616726 0 1.301775628 p.(T316_T317del) 0.954590382 0 1.724091523 p.(T317_Q318del) 0.27989075 1.98E-35 0.502770414 p.(Q318_C319del) 0.677611095 0.000381932 0.98603298 p.(C319_R320del) 0.340930615 1.60E-08 0.88623316 p.(R320_S321del) 0.355731257 8.22E-19 2.15106062 p.(S321_S322del) 0.901470089 1.10E-155 -2.75906757 p.(S322_Y323del) 1.129857687 0 -3.340588369 p.(Y323_L324del) 0.284332092 2.13E-05 -4.961860659 p.(L324_A325del) 0.786294905 7.60E-11 -4.479067265 p.(A325_N326del) 0.924590287 1.56E-12 -2.967183384 p.(N326_E327del) 0.82076007 3.87E-05 -2.994459637 p.(E327_I328del) 0.728940703 6.64E-40 -3.578909994 p.(I328_L329del) 1.008361661 0.000145338 -3.098799214 p.(L329_W330del) 1.18925733 0 -2.825254521 p.(W330_G331del) 0.764818605 8.44E-10 -3.903511912 p.(G331_H332del) 0.505661694 9.10E-22 -4.575993429 p.(H332_R333del) 0.923426912 0 -3.190154914 p.(R333_Y334del) 1.138755293 0 -3.242642101 p.(Y334_E335del) 0.668230715 1.79E-51 -3.532187434 p.(E335_P336del) 0.694553503 2.82E-09 -2.523835748 p.(P336_V337del) 0.988964975 0 -3.128243429 p.(V337_L338del) 0.987155823 4.44E-16 -2.869648908 p.(L338_F339del) 0.605650212 0.005449795 -4.22721243 p.(F339_E340del) 0.997608062 1.83E-106 -2.813317904 p.(E340_E341del) 1.514910548 1.78E-15 -3.908661207 p.(Q293_I295del) 0.363161867 1.16E-22 -4.126378437 p.(D294_D296del) 1.157203164 2.64E-13 -2.90732365 p.(I295_N297del) 1.293777866 0 -4.145444171 p.(D296_A298del) 0.840697521 1.99E-10 -2.675405858 p.(N297_D299del) 1.8779934 2.66E-15 -2.491933677 p.(A298_F300del) 0.391180925 8.91E-45 -4.566065828 p.(D299_E301del) 0.784978666 7.60E-38 -3.314167621 p.(F300_I302del) 0.569672508 4.85E-07 -4.436267108 p.(E301_V303del) 0.682083264 0.002071701 -4.30994487 p.(I302_V304del) 0.95633745 0 -3.828157806 p.(V303_I305del) 1.306683547 0 -4.482663838 p.(V304_L306del) 0.534584279 3.15E-54 -4.302497804 p.(I305_E307del) 1.093978176 6.11E-53 -1.145579056 p.(L306_G308del) 1.045483899 3.86E-38 0.482383144 p.(E307_M309del) 0.834510309 1.32E-86 -0.510849561 p.(G308_V310del) 0.929936382 2.36E-29 0.302988996 p.(M309_E311del) 0.062606814 3.18E-11 0.329269679 p.(V310_A312del) 1.069318664 0.000524265 -0.48854051 p.(E311_T313del) 0.685055156 4.30E-42 -0.715106207 p.(A312_A314del) 0.647012933 1.08E-105 0.094061108 p.(T313_M315del) 0.437985793 0 0.020017679 p.(A314_T316del) 0.777614576 1.94E-45 -0.67095583 p.(M315_T317del) 0.939613948 1.22E-43 -0.750938784 p.(T316_Q318del) 0.601335499 2.07E-39 -0.441385717 p.(T317_C319del) 0.910562078 1.10E-85 -0.131581143 p.(Q318_R320del) 0.537463176 1.62E-09 0.549419571 p.(C319_S321del) 0.488969441 8.33E-74 0.648462656 p.(R320_S322del) 0.823304528 2.22E-16 -3.744516234 p.(S321_Y323del) 1.542615915 1.78E-15 -4.192537404 p.(S322_L324del) 1.225291808 0 -3.889089572 p.(Y323_A325del) 1.300484108 4.50E-10 -4.971408311 p.(L324_N326del) 0.40839496 8.42E-24 -5.143302795 p.(A325_E327del) 1.022443125 0 -4.211544855 p.(N326_I328del) 0.716225637 1.32E-48 -2.505263883 p.(E327_L329del) 2.01065306 0 -4.391265421 p.(I328_W330del) 0.464039884 2.22E-91 -4.214078184 p.(L329_G331del) 0.744626987 9.86E-09 -3.467229725 p.(W330_H332del) 0.727325128 0.005493609 -3.749202598 p.(G331_R333del) 0.602395388 5.18E-59 -3.942750606 p.(H332_Y334del) 0.819681814 0 -3.40922854 p.(R333_E335del) 0.927454994 1.77E-06 -3.962364656 p.(Y334_P336del) 1.034548749 1.36E-13 -2.701111256 p.(E335_V337del) 0.770407977 1.87E-10 -3.515208601 p.(P336_L338del) 0.57632653 6.88E-11 -4.404863565 p.(V337_F339del) 0.664982736 8.09E-31 -3.765008296 p.(L338_E340del) 1.374306753 8.70E-06 -3.793696192 p.(F339_E341del) 0.716024519 1.77E-09 -4.393929918 p.(K342del) 0.561001797 3.67E-82 0.03532698 p.(H343del) 0.653731831 2.19E-48 0.275271163 p.(Y344del) 0.18450495 2.31E-35 0.196367025 p.(K346del) 0.446747963 4.31E-75 -0.336720152 p.(V347del) 1.54927991 0 -2.301102056 p.(D348del) 1.358250912 0 -3.159441876 p.(Y349del) 0.526431661 1.66E-06 -4.898923292 p.(S350del) 1.14015656 0 -2.734881792 p.(R351del) 0.498653802 1.52E-13 -4.020612918 p.(F352del) 1.088212203 4.44E-16 -4.151694255 p.(H353del) 0.646056934 0.000920708 -3.453230905 p.(K354del) 1.508919138 8.88E-16 -3.423870713 p.(T355del) 1.116373377 8.88E-16 -3.737797097 p.(Y356del) 0.922392477 1.45E-14 -2.673691844 p.(E357del) 0.319193576 1.13E-83 -3.614579487 p.(V358del) 1.192968384 4.44E-16 -3.015658699 p.(P359del) 0.551335584 9.65E-11 -0.948322353 p.(N360del) 0.398175001 1.09E-20 0.464781282 p.(T361del) 0.82782087 2.97E-78 -2.479332457 p.(P362del) 0.37862423 6.11E-58 -3.646949075 p.(L363del) 0.473843791 2.09E-23 -4.644648526 p.(C364del) 1.818441692 1.56E-08 -3.698872599 p.(S365del) 0.428651768 5.39E-18 -3.330697888 p.(A366del) 0.62759205 6.32E-15 -4.459620721 p.(R367del) 0.720529808 2.09E-23 -2.537915051 p.(D368del) 0.714010747 1.21E-24 -3.341844044 p.(L369del) 1.10547237 6.56E-06 -1.948362691 p.(A370del) 0.78290116 7.30E-85 0.060467679 p.(E371del) 0.479910477 5.45E-11 0.682148006 p.(K372del) 0.293519025 5.93E-08 1.145794821 p.(K373del) 0.347977693 1.11E-16 -1.049331594 p.(Y374del) 0.236209969 1.82E-82 0.70921164 p.(I375del) 0.475760391 2.22E-16 1.290469534 p.(L376del) 0.044647997 1.15E-26 0.804099131 p.(S377del) 0.42917384 8.56E-05 0.923018842 p.(N378del) 0.441274808 1.92E-35 0.676526493 p.(A379del) 0.795377043 0 1.262539328 p.(N380del) 0.259133396 2.84E-43 2.221404587 p.(S381del) 0.598587563 4.79E-57 0.969821641 p.(F382del) 0.852240872 2.92E-24 -0.769308834 p.(C383del) 0.716664646 0.000146678 0.809399636 p.(Y384del) 0.976053783 7.54E-22 -0.043505051 p.(E385del) 2.104224622 3.55E-15 -3.663745295 p.(N386del) 0.7206795 0.002822556 -2.105036588 p.(E387del) 1.249824971 2.23E-126 -1.969492189 p.(V388del) 0.428754371 8.35E-11 1.112271869 p.(E341_K342del) 1.134575273 8.80E-09 -3.417353079 p.(K342_H343del) 0.84921983 5.90E-56 -2.40137087 p.(H343_Y344del) 0.94538334 4.53E-33 -0.498374571 p.(Y344_Y345del) 0.819512622 6.44E-90 -0.506639009 p.(Y345_K346del) 0.867309508 0.000467951 -1.376085614 p.(K346_V347del) 0.473760299 4.14E-24 -3.043424797 p.(V347_D348del) 0.344483829 2.70E-20 -3.57310705 p.(D348_Y349del) 0.863114295 3.71E-72 -3.717440096 p.(Y349_S350del) 0.48488384 5.81E-08 -4.029311629 p.(S350_R351del) 1.02477197 0 -3.71620111 p.(R351_F352del) 1.051193119 0 -4.266703806 p.(F352_H353del) 0.782261312 1.34E-38 -1.566242977 p.(H353_K354del) 0.844608883 4.28E-50 -3.187103213 p.(K354_T355del) 1.344628349 0 -2.795056016 p.(T355_Y356del) 1.155795339 0 -4.06075405 p.(Y356_E357del) 1.149877719 8.35E-14 -3.849639947 p.(E357_V358del) 0.890029653 4.94E-23 -2.918624082 p.(V358_P359del) 1.29825905 8.88E-16 -4.80989245 p.(P359_N360del) 1.098572403 0 -4.252944086 p.(N360_T361del) 0.55783229 3.92E-10 -4.460311621 p.(T361_P362del) 1.382131148 4.44E-16 -4.347108133 p.(P362_L363del) 0.894950075 1.55E-11 -3.293704884 p.(L363_C364del) 0.600344257 1.06E-16 -4.536163671 p.(C364_S365del) 1.447041818 1.78E-15 -4.696319543 p.(S365_A366del) 0.768637495 6.98E-40 -3.5705201 p.(A366_R367del) 0.726060106 2.56E-09 -3.090419688 p.(R367_D368del) 0.721319793 1.74E-07 -3.425308439 p.(D368_L369del) 0.507410244 1.52E-40 -3.85325244 p.(L369_A370del) 0.813752593 5.18E-06 -3.716713506 p.(A370_E371del) 0.424445167 1.03E-05 0.516860857 p.(E371_K372del) 0.373134996 6.83E-32 0.576644691 p.(K372_K373del) 0.086765309 3.88E-31 1.104126507 p.(K373_Y374del) 0.549402757 6.11E-16 3.271243213 p.(Y374_I375del) 0.423200549 0 4.326919197 p.(I375_L376del) 0.423227323 5.55E-17 1.969511344 p.(L376_S377del) 0.766638959 0 0.665063953 p.(S377_N378del) 1.421477962 4.88E-15 -0.463477586 p.(N378_A379del) 0.321969979 1.27E-26 0.238617827 p.(N380_S381del) 0.292927174 1.56E-18 0.38948433 p.(S381_F382del) 1.137137812 5.01E-23 -2.446712252 p.(F382_C383del) 1.470131315 2.59E-12 -1.037930048 p.(C383_Y384del) 1.046845747 9.52E-05 -0.725355023 p.(Y384_E385del) 1.770112382 1.78E-15 -3.948178456 p.(E385_N386del) 1.003859521 1.79E-19 -3.018689227 p.(N386_E387del) 1.471207464 0.000431035 -0.577731636 p.(E387_V388del) 0.979684696 6.59E-08 -2.598849216 p.(V388_A389del) 0.570290052 7.77E-16 1.253056676 p.(E341_H343del) 0.51961829 1.32E-37 -2.638664522 p.(K342_Y344del) 0.26531793 6.84E-14 0.41658899 p.(H343_Y345del) 0.56191491 2.22E-16 0.055690817 p.(Y344_K346del) 0.520987457 0 1.146423917 p.(Y345_V347del) 0.416350995 1.77E-17 -3.344866098 p.(K346_D348del) 0.548624794 1.01E-51 -4.029084984 p.(V347_Y349del) 0.458371701 1.56E-33 -3.139715918 p.(D348_S350del) 0.965029654 1.28E-42 -2.230039801 p.(Y349_R351del) 0.617775656 4.16E-37 -3.14074395 p.(S350_F352del) 0.858746169 3.14E-53 -2.82540112 p.(R351_H353del) 0.979961308 1.33E-15 -2.281818958 p.(F352_K354del) 0.928732941 6.91E-61 -2.511788272 p.(H353_T355del) 0.904998672 4.44E-16 -3.700495369 p.(K354_Y356del) 1.017272991 0 -3.875090316 p.(T355_E357del) 0.806077461 2.18E-15 -2.727174388 p.(Y356_V358del) 0.297973885 4.39E-07 -4.886866592 p.(E357_P359del) 0.908467249 1.25E-21 -1.884203057 p.(V358_N360del) 1.385424512 0 -3.802807773 p.(P359_T361del) 1.024305876 6.66E-16 -2.990346849 p.(N360_P362del) 0.560130362 8.82E-60 -3.671037095 p.(T361_L363del) 0.6787439 2.12E-41 -2.529475371 p.(P362_C364del) 0.65233727 3.08E-06 -3.983882716 p.(L363_S365del) 0.864786033 5.03E-26 -2.585177591 p.(C364_A366del) 0.572886375 7.42E-85 -3.19806682 p.(S365_R367del) 0.858091317 2.76E-19 -2.693791259 p.(A366_D368del) 0.453493641 3.57E-12 -4.146914997 p.(R367_L369del) 0.815889794 1.09E-06 -3.73264338 p.(D368_A370del) 1.473985687 0 -3.828055375 p.(L369_E371del) 0.709213722 4.88E-13 -3.720992475 p.(A370_K372del) 0.402438211 1.13E-76 0.692713837 p.(E371_K373del) 0.208355954 1.85E-27 0.304992918 p.(K372_Y374del) 0.626747798 0 3.556864788 p.(K373_I375del) 0.643013209 2.22E-16 2.279687951 p.(Y374_L376del) 0.325969939 4.57E-64 2.183500389 p.(I375_S377del) 0.466281934 4.63E-22 1.597399951 p.(L376_N378del) 0.328584492 5.50E-19 0.859297314 p.(S377_A379del) 0.437509447 2.22E-72 0.468842382 p.(N378_N380del) 0.979091215 6.32E-49 0.219506075 p.(A379_S381del) 0.238266363 3.18E-26 0.52290294 p.(N380_F382del) 1.219389992 2.04E-36 -0.339222979 p.(S381_C383del) 0.774869675 0.000226945 -0.09859347 p.(F382_Y384del) 1.099788864 1.47E-08 0.477554508 p.(C383_E385del) 0.940688741 3.34E-34 -1.196317947 p.(Y384_N386del) 1.358641521 2.25E-09 -2.913608489 p.(E385_E387del) 1.703780159 8.88E-16 -1.939147256 p.(N386_V388del) 1.541764382 9.50E-65 -1.880406909 p.(E387_A389del) 1.317391698 5.60E-14 -2.310724504 p.(A389del) 1.166404028 0 2.264798331 p.(L390del) 0.256801476 3.68E-16 1.857527313 p.(T391del) 0.156323962 7.44E-63 0.4473261 p.(S392del) 0.394865264 1.55E-14 1.213471777 p.(K393del) 0.543479297 2.22E-16 1.411374154 p.(E394del) 0.08442316 1.47E-11 -0.564009999 p.(E395del) 0.598739339 0 -0.512617585 p.(E396del) 0.531423931 3.43E-46 1.03689102 p.(E397del) 0.989988168 0 -0.451038839 p.(D398del) 0.253920017 2.25E-64 0.544355635 p.(S399del) 0.358986844 1.78E-25 0.866556104 p.(E400del) 0.245198472 1.74E-52 0.762217802 p.(N401del) 0.372307906 2.21E-53 1.168861367 p.(G402del) 0.124975525 0.00076829 0.450146008 p.(V403del) 0.866461822 2.24E-15 0.049895514 p.(P404del) 0.476023094 2.11E-32 1.386157271 p.(E405del) 0.707989796 5.09E-24 0.312249066 p.(S406del) 0.651779702 0 0.047323296 p.(T407del) 0.303937484 1.73E-20 0.894997984 p.(S408del) 0.306524867 7.57E-133 -0.126865988 p.(T409del) 0.708786235 1.46E-41 0.22278753 p.(D410del) 0.528168984 9.27E-76 0.120288613 p.(S411del) 0.444078343 9.07E-05 1.359915088 p.(P412del) 0.417335191 8.66E-49 1.026435025 p.(P413del) 0.539351812 0 1.260867243 p.(G414del) 0.123629732 2.26E-78 1.320599599 p.(I415del) 0.178863962 8.29E-18 1.258652722 p.(D416del) 0.54883435 1.09E-55 0.016308455 p.(L417del) 0.432310035 3.80E-52 0.946368556 p.(H418del) 0.261493826 1.63E-08 0.606582564 p.(N419del) 0.395882464 3.46E-13 0.545251956 p.(Q420del) 0.25329865 2.35E-14 0.395498012 p.(A421del) 0.510026575 3.44E-24 0.675620961 p.(S422del) 0.41639674 2.24E-08 1.300096578 p.(V423del) 1.373789837 0 1.98809891 p.(P424del) 0.243841984 0.000623056 1.292805674 p.(L425del) 0.529829191 2.60E-48 0.217329643 p.(E426del) 0.431849241 1.45E-36 -0.203609075 p.(P427del) 0.322075434 1.15E-05 -1.317466352 p.(R428del) 0.570647324 1.28E-11 2.041841436 p.(P429del) 0.76025594 4.44E-16 2.220868195 p.(L430del) 0.775527969 1.75E-14 2.798842117 p.(R431del) 0.501058758 3.67E-53 0.483621963 p.(R432del) 0.216149156 0.000134764 2.243720936 p.(E433del) 0.734502338 1.71E-71 0.169253091 p.(S434del) 0.720712215 0 0.973510245 p.(E435del) 0.665753972 6.66E-16 1.695925937 p.(A389_L390del) 0.846116906 0 3.221899959 p.(L390_T391del) 0.416077788 1.44E-11 2.395184134 p.(T391_S392del) 0.558730921 5.39E-45 0.567611933 p.(S392_K393del) 0.318438321 2.30E-46 0.695300643 p.(K393_E394del) 0.271261424 3.92E-32 0.810916412 p.(E394_E395del) 0.537804177 1.06E-65 0.446378333 p.(E397_D398del) 0.679627673 3.51E-46 0.003460723 p.(D398_S399del) 0.410719086 0.000282479 0.802591433 p.(S399_E400del) 0.288254581 1.42E-66 0.622347759 p.(E400_N401del) 0.118352843 2.32E-84 -0.097767798 p.(N401_G402del) 0.401670019 1.51E-34 0.647380226 p.(G402_V403del) 0.794802698 0 0.218992172 p.(V403_P404del) 0.597819631 0 0.734210377 p.(P404_E405del) 0.643617162 4.37E-59 0.213432787 p.(E405_S406del) 0.489880753 3.25E-13 0.373746346 p.(S406_T407del) 0.137545378 5.97E-48 0.659795629 p.(T407_S408del) 0.406994098 5.76E-61 0.78506713 p.(T409_D410del) 0.359355126 1.33E-59 0.24812769 p.(D410_S411del) 0.717687264 1.05E-62 0.31377163 p.(S411_P412del) 0.963452135 8.88E-16 1.08161597 p.(P412_P413del) 0.846805893 4.28E-35 -0.263034983 p.(P413_G414del) 0.608746519 5.81E-08 1.034974773 p.(G414_I415del) 0.560682949 1.10E-22 0.96407049 p.(I415_D416del) 0.308241144 7.13E-40 0.193657909 p.(D416_L417del) 0.605297107 1.41E-49 0.643336316 p.(L417_H418del) 0.449559721 1.11E-33 1.209071614 p.(H418_N419del) 0.249448063 2.85E-39 1.015043796 p.(N419_Q420del) 0.417270681 1.80E-55 -0.200764399 p.(Q420_A421del) 0.644260485 9.39E-19 0.531021213 p.(A421_S422del) 0.36670125 5.54E-35 0.799655042 p.(S422_V423del) 0.681092838 9.66E-09 -0.384518971 p.(V423_P424del) 0.935370742 1.42E-35 0.561786566 p.(P424_L425del) 0.513702009 1.11E-16 1.336661231 p.(L425_E426del) 0.718355521 1.84E-58 -0.25597847 p.(E426_P427del) 0.347977693 1.11E-16 -1.049331594 p.(P427_R428del) 0.369752584 1.64E-39 1.577926223 p.(P429_L430del) 0.756107435 0 1.045076147 p.(L430_R431del) 0.305757042 6.06E-59 1.121269529 p.(R431_R432del) 0.395416265 2.62E-21 2.741118585 p.(R432_E433del) 0.526029793 1.95E-35 0.138871398 p.(E433_S434del) 0.600026903 9.58E-51 -0.135782307 p.(S434_E435del) 0.744933043 6.67E-10 -1.623041415 p.(A389_T391del) 0.490954123 0 1.784675513 p.(L390_S392del) 0.761076004 2.45E-06 1.679244151 p.(T391_K393del) 0.410513735 5.73E-41 1.056795482 p.(S392_E394del) 0.751635273 1.14E-87 0.505197206 p.(K393_E395del) 0.686896737 4.41E-27 0.399029829 p.(E394_E396del) 0.745562967 6.74E-66 -0.246000247 p.(E396_D398del) 0.741036599 8.37E-49 0.04014721 p.(E397_S399del) 1.146312477 7.33E-09 -0.962550701 p.(D398_E400del) 0.463798516 8.42E-18 -0.477113826 p.(S399_N401del) 0.485193173 6.02E-69 0.771892391 p.(E400_G402del) 0.521292359 2.22E-16 0.40225146 p.(N401_V403del) 0.760429461 1.21E-44 0.365385299 p.(G402_P404del) 0.497023532 2.56E-72 0.657097413 p.(V403_E405del) 0.769305019 3.82E-24 0.474240482 p.(P404_S406del) 0.874043898 1.96E-94 0.068753208 p.(E405_T407del) 0.301785834 2.12E-90 0.646641974 p.(S406_S408del) 0.752661629 0 -0.35326324 p.(T407_T409del) 0.530364757 7.80E-58 0.295749075 p.(S408_D410del) 0.663777179 2.84E-71 -0.22607795 p.(T409_S411del) 0.649227619 1.34E-16 0.194795622 p.(D410_P412del) 0.796670857 2.95E-62 -0.534707614 p.(S411_P413del) 0.443185513 2.04E-08 0.734661351 p.(P412_G414del) 0.610610056 2.38E-14 0.639858618 p.(P413_I415del) 0.629368678 3.54E-41 0.638740765 p.(G414_D416del) 0.158398778 3.21E-11 0.902536434 p.(I415_L417del) 0.615736909 1.93E-38 0.083427366 p.(D416_H418del) 0.607928158 6.36E-31 -0.324937048 p.(L417_N419del) 0.506915082 5.34E-31 0.287045484 p.(H418_Q420del) 0.354136487 0.000687722 0.441678364 p.(N419_A421del) 1.00068634 2.57E-42 0.202823223 p.(Q420_S422del) 0.544392044 6.09E-41 0.407262623 p.(A421_V423del) 0.214483072 8.63E-64 0.483890461 p.(S422_P424del) 0.662383206 1.31E-30 -0.250029217 p.(V423_L425del) 0.332885627 3.48E-19 0.912350093 p.(P424_E426del) 0.358566924 1.48E-55 0.06344703 p.(L425_P427del) 0.487486436 5.87E-21 0.344301894 p.(E426_R428del) 0.521926383 2.03E-34 0.807247558 p.(P427_P429del) 1.129340889 0 1.153760528 p.(R428_L430del) 0.681135735 6.66E-16 1.391170825 p.(P429_R431del) 0.447753315 1.35E-25 1.418864341 p.(L430_R432del) 0.777829492 2.18E-14 2.581957161 p.(R431_E433del) 0.703496698 5.72E-39 0.66234214 p.(R432_S434del) 0.72124117 9.03E-13 0.561430952 p.(A22A) 0.077130578 1.06E-10 0.171626105 p.(A22R) 0.316007704 6.58E-24 1.421849377 p.(A22N) 0.292952861 2.01E-09 0.545619699 p.(A22D) 0.261680035 1.29E-09 1.253864996 p.(A22C) 0.63102278 8.26E-79 -0.668381994 p.(A22Q) 0.258816433 0.000181869 1.089915448 p.(A22E) 0.253312463 2.71E-12 0.354499772 p.(A22G) 0.486566141 0.001961104 1.183402251 p.(A22H) 0.316265268 1.86E-05 1.108652139 p.(A22I) 1.427216251 9.93E-88 -1.933511801 p.(A22L) 1.184628895 9.11E-60 -1.687297172 p.(A22K) 0.372525198 0 1.302381021 p.(A22M) 0.897667742 2.53E-69 -0.371883253 p.(A22F) 1.031942481 1.34E-16 -0.345515397 p.(A22P) 0.34887711 0 0.184266842 p.(A22S) 0.426349241 0 1.210924475 p.(A22T) 0.142871713 1.02E-31 1.272928832 p.(A22W) 0.759080366 1.41E-46 -1.263888545 p.(A22Y) 0.861272805 1.08E-161 -0.439400603 p.(A22V) 0.47299633 4.50E-73 -0.953886039 p.(A25A) 0.254761053 8.67E-39 1.022726381 p.(A25R) 0.401114958 2.25E-52 0.794248674 p.(A25N) 0.751938649 0 3.086396577 p.(A25D) 0.278963791 1.37E-86 -0.111733589 p.(A25C) 0.386049069 2.53E-42 0.479348101 p.(A25Q) 0.396338059 4.66E-12 2.437878633 p.(A25E) 0.336526307 0.000278753 1.772682187 p.(A25G) 0.263440827 0.000332071 1.009712386 p.(A25H) 0.153757291 2.07E-50 1.651939074 p.(A25I) 0.644345614 1.38E-28 -0.440175657 p.(A25L) 1.065454599 1.36E-27 -0.226375377 p.(A25K) 0.376628561 2.26E-72 0.519780906 p.(A25M) 0.35218033 4.21E-37 0.213652207 p.(A25F) 0.80409957 1.05E-109 -0.038160455 p.(A25P) 0.705884631 0 2.865801184 p.(A25S) 0.480651768 5.55E-17 2.199703958 p.(A25T) 0.274876564 1.05E-16 1.603927197 p.(A25W) 0.955733017 5.78E-44 0.351620355 p.(A25Y) 0.29656384 2.83E-140 0.389593538 p.(A25V) 0.779911508 8.83E-87 -0.290152433 p.(A27A) 0.15948056 0 0.31983895 p.(A27R) 0.789756094 0 1.295524809 p.(A27N) 0.330780264 8.33E-17 1.325949797 p.(A27D) 0.334252536 1.68E-28 0.331910757 p.(A27C) 0.431190733 1.17E-11 -0.356298914 p.(A27Q) 0.250500475 6.41E-20 1.107117192 p.(A27E) 0.868321933 2.22E-16 2.432542974 p.(A27G) 0.579781852 0 1.77802185 p.(A27H) 0.412707459 6.79E-20 0.93961722 p.(A27I) 1.037118642 4.41E-88 0.027869839 p.(A27L) 0.717756502 8.50E-68 -0.344442191 p.(A27K) 0.39662752 1.10E-166 0.684436117 p.(A27M) 0.639743439 8.03E-80 -0.261452019 p.(A27F) 0.946022511 1.01E-72 -0.232888087 p.(A27P) 0.636562634 0 0.952822944 p.(A27S) 0.741774206 1.11E-15 0.704545229 p.(A27T) 0.451371903 2.78E-16 1.925683242 p.(A27W) 0.920441171 1.34E-93 -0.517666861 p.(A27Y) 0.728515276 6.62E-184 -0.561331134 p.(A27V) 0.123165573 1.83E-29 0.535081504 p.(R40A) 0.283983685 2.56E-11 1.340285423 p.(R40R) 0.146067691 2.00E-72 -0.3553345 p.(R40N) 0.213425834 3.42E-11 1.259139625 p.(R40D) 0.296707239 1.07E-07 1.465740732 p.(R40C) 0.210257294 9.53E-13 -0.724310449 p.(R40Q) 0.663438923 0 0.660816871 p.(R40E) 0.467676437 0 2.887540375 p.(R40G) 0.050551724 1.59E-19 1.234274233 p.(R40H) 0.297740253 9.16E-14 1.388467624 p.(R40I) 0.48816608 9.37E-36 0.744670124 p.(R40L) 0.132541433 4.14E-10 0.10383373 p.(R40K) 0.265838086 4.33E-05 1.361434652 p.(R40M) 0.198409679 3.98E-11 0.315679964 p.(R40F) 0.559885245 4.56E-62 -0.090444465 p.(R40P) 0.405024125 0.001170454 0.047962107 p.(R40S) 0.286160187 9.12E-40 1.579015049 p.(R40T) 0.245332698 1.87E-15 1.954867826 p.(R40W) 0.382474779 1.60E-111 0.094843852 p.(R40Y) 0.531317579 8.27E-52 0.590606773 p.(R40V) 0.25556268 5.08E-29 1.177624423 p.(R44A) 0.270183106 2.42E-15 2.376490612 p.(R44R) 0.168799698 0 0.187343976 p.(R44N) 0.141582636 1.39E-11 1.357243199 p.(R44D) 0.261688552 0.000772716 1.899135564 p.(R44C) 0.227264438 2.18E-79 0.526984604 p.(R44Q) 0.411181016 1.39E-16 0.353791012 p.(R44E) 0.487522939 7.16E-16 1.63987278 p.(R44G) 0.374259784 3.20E-08 1.632782313 p.(R44H) 0.265157716 0 1.008256103 p.(R44I) 0.141114272 2.06E-09 0.709894518 p.(R44L) 0.232697776 0 -0.014964729 p.(R44K) 0.496063459 2.87E-35 0.386573412 p.(R44M) 0.409183386 6.44E-51 0.653812997 p.(R44F) 0.287102555 1.15E-12 0.617681305 p.(R44P) 0.214495426 1.22E-63 0.365148559 p.(R44S) 0.501256642 0 1.891031447 p.(R44T) 0.105103834 5.63E-17 1.430325835 p.(R44W) 0.091188064 2.56E-46 -0.50543756 p.(R44Y) 0.302535472 1.67E-07 0.364987014 p.(R44V) 0.990159743 0 2.297557914 p.(R46A) 0.56874144 8.42E-35 -1.608002866 p.(R46R) 0.22718456 4.16E-17 0.313784763 p.(R46N) 0.708232879 2.99E-10 -2.916768947 p.(R46D) 0.785656081 1.11E-67 -3.418148509 p.(R46C) 0.771582692 7.36E-73 -1.608571935 p.(R46Q) 0.43872311 2.05E-38 -2.730749973 p.(R46E) 1.173938867 0 -2.183906958 p.(R46G) 0.569991024 8.62E-69 -2.514778768 p.(R46H) 0.791579793 7.40E-06 -0.971662249 p.(R46I) 0.522838889 1.41E-09 -4.830767481 p.(R46L) 0.42379006 1.17E-31 -4.046245459 p.(R46K) 0.960814074 7.02E-09 -3.183842367 p.(R46M) 0.693106912 3.97E-05 -1.989459746 p.(R46F) 1.039318782 0 -3.536398446 p.(R46P) 0.947580048 4.16E-45 -1.115268619 p.(R46S) 0.220196325 1.28E-79 -2.70011577 p.(R46T) 0.777227181 1.06E-09 -3.582816457 p.(R46W) 0.62919006 4.62E-37 -3.289282077 p.(R46Y) 1.47575058 0 -2.069866104 p.(R46V) 2.233762005 3.55E-15 -3.489456801 p.(R5A) 0.568721752 1.11E-16 1.420077362 p.(R5R) 0.104192627 1.64E-05 0.375082932 p.(R5N) 0.296752278 5.50E-13 0.923184748 p.(R5D) 0.501601178 3.62E-10 2.606495172 p.(R5C) 0.675189683 6.32E-62 0.180790246 p.(R5Q) 0.199085957 3.91E-29 -0.521413014 p.(R5E) 0.554306251 2.22E-16 2.667949791 p.(R5G) 0.890388554 0 1.844662369 p.(R5H) 0.479670283 3.60E-63 0.585474308 p.(R5I) 0.611530617 3.24E-81 0.427924836 p.(R5L) 0.506575016 6.70E-49 -0.593748886 p.(R5K) 0.816162813 0 0.844093372 p.(R5M) 0.332199161 1.47E-13 -0.737830327 p.(R5F) 0.509899341 4.18E-14 -0.359219788 p.(R5P) 0.713961312 0 1.940122445 p.(R5S) 0.248565612 1.13E-07 0.986443965 p.(R5T) 0.530538587 0 2.102784677 p.(R5W) 1.264275462 3.67E-20 -1.376399065 p.(R5Y) 0.922166607 3.28E-82 -0.160757912 p.(R5V) 0.505487752 7.04E-81 0.104185168 p.(R8A) 0.238420356 8.31E-34 0.588733076 p.(R8R) 0.173023799 1.81E-13 0.219384245 p.(R8N) 0.459857444 0 0.587265258 p.(R8D) 0.272764416 2.82E-53 1.611640766 p.(R8C) 0.648550785 2.31E-81 -0.000294674 p.(R8Q) 0.123571042 1.48E-26 -0.585756399 p.(R8E) 0.265173184 5.55E-17 1.594737332 p.(R8G) 0.840694286 9.03E-66 -0.134053104 p.(R8H) 1.352070983 1.36E-50 0.141736104 p.(R8I) 0.609759738 4.73E-158 -0.286652212 p.(R8L) 0.609777698 1.09E-58 -0.500387676 p.(R8K) 0.496879563 7.28E-76 -0.229416549 p.(R8M) 0.698650713 5.14E-54 -0.036076598 p.(R8F) 0.861269976 5.63E-179 -0.278972311 p.(R8P) 0.799684105 6.09E-93 -0.329503481 p.(R8S) 0.72099868 0 1.774801148 p.(R8T) 0.231025663 5.12E-87 0.151123458 p.(R8W) 0.319751435 5.20E-33 -1.01569638 p.(R8Y) 1.389339842 6.74E-49 0.341540091 p.(R8V) 0.642733539 8.19E-94 -0.139055688 p.(N28A) 0.239976207 1.28E-41 0.897812363 p.(N28R) 0.369232538 4.06E-90 0.323739833 p.(N28N) 0.114767869 7.51E-60 -0.642119386 p.(N28D) 0.491206297 2.09E-13 2.120237066 p.(N28C) 0.407531878 3.68E-71 -0.472110146 p.(N28Q) 0.282112031 2.90E-18 0.361813826 p.(N28E) 0.422194316 1.64E-21 2.141432479 p.(N28G) 0.261715801 5.14E-10 1.342879666 p.(N28H) 0.376489161 7.21E-11 0.623679287 p.(N28I) 0.845916375 1.32E-33 -0.916439116 p.(N28L) 0.840157167 4.92E-64 -0.627222173 p.(N28K) 0.4277139 1.65E-43 -0.079437354 p.(N28M) 0.860268683 4.78E-68 -0.411271307 p.(N28F) 0.783617988 5.00E-60 -1.109436099 p.(N28P) 0.349363105 5.74E-64 1.617861379 p.(N28S) 0.264162091 1.27E-07 1.34356314 p.(N28T) 0.251776836 5.67E-36 0.966337653 p.(N28W) 1.098496517 7.65E-37 -1.563533883 p.(N28Y) 0.976603283 2.75E-94 -0.252717763 p.(N28V) 0.802899312 2.80E-72 -0.334995134 p.(N32A) 0.294670028 5.97E-10 0.40313006 p.(N32R) 0.617908716 1.43E-36 0.653171565 p.(N32N) 0.145381726 1.49E-08 1.000457959 p.(N32D) 0.28329933 1.94E-62 0.846836024 p.(N32C) 0.526478382 1.43E-26 0.479483513 p.(N32Q) 0.239555282 4.78E-27 0.641163237 p.(N32E) 1.026766985 0 2.854044336 p.(N32G) 0.494600275 1.67E-16 0.10753428 p.(N32H) 0.607557146 1.83E-105 0.329010186 p.(N32I) 0.423708554 5.55E-17 0.860299554 p.(N32L) 0.435821193 5.64E-50 -0.220011978 p.(N32K) 0.446053451 3.64E-40 0.304526805 p.(N32M) 0.370931954 7.37E-16 0.13228833 p.(N32F) 0.956637738 3.47E-62 -0.388995245 p.(N32P) 0.534462573 0 1.009059575 p.(N32S) 0.295291473 2.21E-08 1.215312708 p.(N32T) 0.472840255 1.67E-16 1.845872691 p.(N32W) 1.128862718 3.39E-88 -0.379207072 p.(N32Y) 0.762352304 1.79E-59 -0.381822794 p.(N32V) 0.245948635 1.19E-12 1.143695061 p.(N7A) 0.374036756 2.63E-36 0.516207312 p.(N7R) 0.198564418 3.23E-28 1.571605363 p.(N7D) 0.272001054 5.28E-14 1.589204935 p.(N7C) 0.272901955 2.34E-115 -0.138260972 p.(N7Q) 0.397852839 1.94E-28 0.411589921 p.(N7E) 0.901454759 4.44E-16 2.9327992 p.(N7G) 0.202646677 0 1.641838116 p.(N7H) 0.260188266 8.77E-67 1.162040908 p.(N7I) 0.894620933 5.40E-82 -0.588385191 p.(N7L) 0.859024549 1.63E-72 -0.143937582 p.(N7K) 0.61418626 0 1.883081348 p.(N7M) 0.621852953 1.13E-48 -0.00528383 p.(N7F) 0.933411731 1.53E-14 -0.610131711 p.(N7P) 0.251167286 1.74E-71 0.627787694 p.(N7S) 0.408427126 0 -0.080610159 p.(N7T) 0.141915148 3.01E-24 1.746361452 p.(N7W) 1.027504022 3.63E-75 0.091026079 p.(N7Y) 0.99830825 3.71E-33 -0.622534386 p.(N7V) 0.857395282 1.78E-67 -0.325948862 p.(D17A) 0.460953381 3.18E-70 0.146454332 p.(D17R) 0.466425707 7.76E-39 -0.328945836 p.(D17N) 0.136179886 9.97E-12 -0.561015127 p.(D17C) 0.297572198 1.81E-42 0.062893303 p.(D17Q) 0.451204036 1.55E-63 0.589411291 p.(D17E) 0.285692704 6.72E-20 0.588819201 p.(D17G) 0.617545201 1.78E-53 0.094230377 p.(D17H) 0.558930267 2.97E-101 0.215610309 p.(D17I) 0.977824332 1.30E-68 -0.390212036 p.(D17L) 0.930858315 3.00E-46 -0.696337439 p.(D17K) 0.604228379 9.50E-96 0.10379121 p.(D17M) 0.772676341 1.63E-51 -0.246153375 p.(D17F) 1.057818965 3.58E-82 -0.282847023 p.(D17P) 0.260507627 3.39E-67 -0.087135283 p.(D17S) 0.7508597 2.85E-27 0.087342427 p.(D17T) 0.749496397 6.09E-61 0.579085121 p.(D17W) 0.88071798 6.26E-53 -1.151909802 p.(D17Y) 0.625086842 2.32E-58 -0.559201249 p.(D17V) 0.653711883 4.37E-89 0.331150768 p.(C43A) 0.34965304 0 1.260608159 p.(C43R) 0.086874401 1.47E-84 -0.314724461 p.(C43N) 0.227812333 4.16E-17 1.289249196 p.(C43D) 0.288734002 2.32E-06 1.652670691 p.(C43C) 0.03883076 1.32E-14 -0.579715545 p.(C43Q) 0.269797025 1.30E-12 0.41311073 p.(C43E) 0.331707456 4.64E-06 2.652643935 p.(C43G) 0.344211051 3.36E-14 1.206907667 p.(C43H) 0.38469264 1.05E-12 0.507699695 p.(C43I) 0.501122039 1.67E-16 1.26621461 p.(C43L) 0.560907463 3.94E-37 0.202113485 p.(C43K) 0.250170608 2.86E-41 0.980848037 p.(C43M) 0.334855058 2.68E-31 0.806638156 p.(C43F) 0.132382077 1.24E-13 -0.301701284 p.(C43P) 0.491333675 1.67E-16 1.736959668 p.(C43S) 0.346541409 5.55E-17 -0.016742061 p.(C43T) 0.487560641 1.67E-16 1.65402575 p.(C43W) 0.214483547 2.91E-27 -0.110132364 p.(C43Y) 0.463521777 5.44E-52 0.36074251 p.(C43V) 0.472883086 0 1.871510369 p.(Q41A) 0.337177814 5.53E-08 0.761179564 p.(Q41R) 0.45540347 2.69E-67 0.145501422 p.(Q41N) 0.320407198 1.96E-59 0.857685742 p.(Q41D) 0.46427596 0 1.914844589 p.(Q41C) 0.984369119 1.83E-150 -0.147206029 p.(Q41Q) 0.297099458 0 0.588958667 p.(Q41E) 0.152597685 1.42E-07 1.349540185 p.(Q41G) 0.14715573 0.000273774 1.045696226 p.(Q41H) 0.258260512 1.10E-58 0.007371331 p.(Q41I) 0.512052814 4.50E-27 0.7361575 p.(Q41L) 0.555187663 1.90E-63 -0.097471254 p.(Q41K) 0.198344535 1.11E-07 -0.788313552 p.(Q41M) 0.419237468 5.31E-47 0.457433205 p.(Q41F) 0.743604405 3.68E-99 -0.144621797 p.(Q41P) 0.130234476 6.45E-11 0.622842789 p.(Q41S) 0.557225989 0 0.639521226 p.(Q41T) 0.241115869 1.69E-73 0.993900427 p.(Q41W) 0.789778304 5.46E-51 -0.36067556 p.(Q41Y) 0.837893632 1.14E-70 0.111628972 p.(Q41V) 0.306065496 6.34E-07 0.409312795 p.(Q42A) 0.148235442 2.13E-41 0.374517727 p.(Q42R) 0.361156294 3.60E-16 0.644149474 p.(Q42N) 0.182187568 1.29E-43 0.627724225 p.(Q42D) 0.861402041 0 2.371106594 p.(Q42C) 0.427749182 1.38E-52 0.593209929 p.(Q42E) 0.501251671 1.11E-16 2.211746836 p.(Q42G) 0.334864273 2.82E-35 1.264570675 p.(Q42H) 0.069978887 5.74E-37 -0.497495041 p.(Q42I) 0.331590078 5.73E-58 0.834187416 p.(Q42L) 0.396733299 1.72E-15 0.645230575 p.(Q42K) 0.349878133 3.80E-91 0.017254793 p.(Q42M) 0.427919444 1.30E-33 0.020748293 p.(Q42F) 0.769238172 1.32E-112 -0.177970897 p.(Q42P) 0.175211243 4.76E-40 1.065305466 p.(Q42S) 0.377416519 8.04E-08 0.291056887 p.(Q42T) 0.232574 6.86E-49 1.172999444 p.(Q42W) 0.732060717 1.57E-123 -0.24816611 p.(Q42Y) 0.381080514 2.91E-30 0.332942575 p.(Q42V) 0.088937334 1.01E-43 0.565613617 p.(E15A) 0.547061286 0 0.441778974 p.(E15R) 0.731421162 2.00E-59 -0.149188051 p.(E15N) 0.43126624 1.11E-16 0.362484662 p.(E15D) 0.21734387 2.61E-49 0.60034839 p.(E15C) 0.759011697 6.57E-59 -0.236522355 p.(E15Q) 0.50912786 7.20E-39 0.605232956 p.(E15E) 0.1285846 8.75E-08 -0.141344968 p.(E15G) 0.598577917 8.81E-101 0.769235405 p.(E15H) 0.596295748 1.07E-49 0.1618175 p.(E15I) 0.924350924 5.55E-37 -0.887438033 p.(E15L) 0.885028217 1.18E-65 -0.156682311 p.(E15K) 0.314000967 9.46E-64 -0.791688764 p.(E15M) 1.349676599 2.01E-79 -0.003632572 p.(E15F) 0.835874112 5.85E-53 -0.679724645 p.(E15P) 0.512950643 1.64E-43 0.338405129 p.(E15S) 0.309861486 7.89E-13 -0.172638249 p.(E15T) 0.75073213 1.43E-50 0.161698771 p.(E15W) 0.561395235 7.70E-27 -1.025825768 p.(E15Y) 0.946938482 3.07E-89 -0.755646544 p.(E15V) 0.744153116 5.82E-101 -0.458781953 p.(E16A) 0.328873811 3.25E-57 0.231494825 p.(E16R) 0.857234736 2.65E-117 -0.303652807 p.(E16N) 0.74829323 2.06E-69 -0.226828695 p.(E16D) 0.139833722 1.93E-20 0.078260747 p.(E16C) 1.131782342 1.60E-96 0.255933872 p.(E16Q) 0.538696431 1.11E-77 0.218326947 p.(E16G) 0.90772593 2.60E-37 -0.23960964 p.(E16H) 0.986507389 8.48E-79 0.135005044 p.(E16I) 0.460524985 3.07E-66 -0.682424324 p.(E16L) 0.855500809 4.33E-97 -0.536240519 p.(E16K) 0.97175861 1.47E-52 -0.442909645 p.(E16M) 0.856343427 1.78E-124 -0.318043656 p.(E16F) 0.880351988 2.29E-93 -0.617698051 p.(E16P) 0.72105432 5.83E-89 -0.063687732 p.(E16S) 1.024524037 1.21E-66 -0.26276915 p.(E16T) 0.985033284 2.93E-75 0.014011558 p.(E16W) 1.028759377 9.59E-37 -1.179095268 p.(E16Y) 0.982287635 2.83E-14 0.116902692 p.(E16V) 0.730755755 1.32E-83 -0.337959278 p.(G18A) 0.106127731 4.52E-12 -0.385306571 p.(G18R) 0.587658266 3.62E-95 0.171421985 p.(G18N) 0.581073121 5.22E-20 0.292657438 p.(G18D) 0.566541936 3.30E-116 0.068586048 p.(G18C) 0.895219103 2.78E-42 -0.608740259 p.(G18Q) 0.225568264 6.51E-06 0.089015657 p.(G18E) 0.151729027 1.74E-14 -0.209314916 p.(G18G) 0.356894281 3.68E-26 0.776901293 p.(G18H) 0.502232472 2.23E-40 0.053812192 p.(G18I) 0.905356005 3.34E-64 -0.004149195 p.(G18L) 0.82077943 1.63E-30 -1.074480758 p.(G18K) 0.763383818 1.05E-19 -0.450565814 p.(G18M) 1.141382921 1.46E-79 -0.106280789 p.(G18F) 1.111277557 2.52E-78 -0.144812075 p.(G18P) 0.770560085 2.14E-137 -0.09347523 p.(G18S) 0.754593965 4.27E-55 0.339236861 p.(G18T) 0.975401286 1.05E-38 -0.401050863 p.(G18W) 0.338723271 2.20E-56 -1.309761016 p.(G18Y) 1.23205409 6.49E-28 -0.175107548 p.(G18V) 0.84812361 7.99E-97 -0.42387793 p.(G29A) 0.456786666 1.11E-16 1.418225615 p.(G29R) 0.589062136 8.02E-96 0.085091372 p.(G29N) 0.371480586 3.34E-14 1.501352863 p.(G29D) 0.411115826 2.57E-05 2.96764983 p.(G29C) 0.962500411 1.08E-60 -0.721985498 p.(G29Q) 0.186261332 1.15E-43 0.68311946 p.(G29E) 1.142253149 0 4.180859157 p.(G29H) 0.329555607 0.00011579 0.528710468 p.(G29I) 0.859589764 8.81E-107 -0.021443315 p.(G29L) 0.873351565 4.30E-40 -0.729662487 p.(G29K) 0.88060616 3.76E-89 0.344948868 p.(G29M) 0.793033087 7.30E-70 -0.635479431 p.(G29F) 0.761395662 0.005462516 -1.65224579 p.(G29P) 0.382820621 4.08E-77 0.269103975 p.(G29S) 0.234821868 1.39E-17 -0.581255379 p.(G29T) 0.522413471 0 0.663347764 p.(G29W) 1.29357603 2.62E-42 -1.80768978 p.(G29Y) 0.686043459 6.76E-20 -1.353873553 p.(G29V) 1.037379569 2.19E-57 -0.125274003 p.(G2A) 0.226116747 3.05E-10 0.72124941 p.(G2R) 0.919570114 2.93E-32 -1.010584457 p.(G2N) 0.724819737 1.55E-29 -0.302849763 p.(G2D) 0.155224835 3.73E-28 0.044778204 p.(G2C) 1.058144476 5.60E-57 -1.426737688 p.(G2Q) 0.537227901 6.52E-11 0.139324255 p.(G2E) 0.030974604 6.25E-29 0.36733619 p.(G2G) 0.219787141 5.81E-07 0.768812561 p.(G2H) 0.923264658 3.78E-89 -0.130216548 p.(G2I) 0.72342337 5.27E-24 -0.017563111 p.(G2L) 0.63849583 2.40E-92 -1.110226197 p.(G2K) 0.951377654 9.35E-44 -0.798631317 p.(G2M) 0.984653674 6.62E-11 -1.075389213 p.(G2F) 0.880834321 8.92E-40 -1.554466932 p.(G2P) 0.415867773 6.03E-72 -0.439588674 p.(G2S) 0.541151996 2.22E-16 0.917173823 p.(G2T) 0.106354962 3.94E-137 0.318306726 p.(G2W) 0.93043604 6.44E-53 -1.802441944 p.(G2Y) 0.785972047 7.54E-12 -0.106301452 p.(G2V) 0.872456276 1.39E-21 -0.102513625 p.(G31A) 0.220477035 2.70E-33 1.089378582 p.(G31R) 0.135708402 2.06E-41 -0.741869196 p.(G31N) 0.360628945 0 0.352855012 p.(G31D) 0.573564283 1.11E-16 1.414259992 p.(G31C) 0.779072602 4.38E-79 0.104386486 p.(G31Q) 0.416341213 0 0.955282167 p.(G31E) 0.141418314 1.18E-31 -0.21867719 p.(G31G) 0.151048548 8.39E-19 0.072477644 p.(G31H) 0.408694819 3.37E-79 0.638555007 p.(G31I) 0.604226672 1.82E-48 0.095854344 p.(G31L) 0.952006721 1.18E-31 -0.377783934 p.(G31K) 0.533727918 1.11E-16 0.511108806 p.(G31M) 0.390926132 3.63E-08 -0.846301757 p.(G31F) 0.462535925 1.48E-71 -0.431634631 p.(G31P) 0.208820874 4.43E-27 0.972231173 p.(G31S) 0.242609526 2.47E-37 0.360132003 p.(G31T) 0.106501159 7.03E-36 0.853214559 p.(G31W) 0.534955575 1.55E-90 -0.389919393 p.(G31Y) 1.033347064 7.57E-89 -0.174164653 p.(G31V) 0.296410978 1.03E-35 -0.10078885 p.(G33A) 0.75139218 0 0.9787811 p.(G33R) 0.601440204 2.00E-148 0.078320095 p.(G33N) 0.396462573 1.25E-31 1.035578444 p.(G33D) 0.380673062 1.78E-19 1.654986532 p.(G33C) 0.525629576 9.81E-38 0.742163848 p.(G33Q) 0.155669445 1.16E-19 0.979114418 p.(G33E) 0.251805235 1.73E-52 0.160513705 p.(G33G) 0.325076849 8.10E-09 1.303021928 p.(G33H) 0.623870774 5.65E-75 -0.125884157 p.(G33I) 0.535275428 2.50E-30 0.104965214 p.(G33L) 0.269201686 4.40E-10 0.211198488 p.(G33K) 0.618902881 5.73E-35 0.789603118 p.(G33M) 0.36059459 7.47E-10 1.202273628 p.(G33F) 0.620155569 3.82E-45 0.026925396 p.(G33P) 0.365149215 0 1.27535571 p.(G33S) 0.23447757 2.00E-15 0.80494508 p.(G33T) 0.355050605 3.19E-14 1.419849458 p.(G33W) 0.509253493 9.03E-98 -0.460979897 p.(G33Y) 0.860853374 2.69E-67 -0.024413306 p.(G33V) 0.099181189 7.40E-13 0.45292459 p.(H38A) 0.350706958 2.60E-14 1.121441965 p.(H38R) 0.353649376 9.44E-143 0.412818216 p.(H38N) 0.203853746 0.000979146 1.102584522 p.(H38D) 0.119258184 3.01E-22 1.113513127 p.(H38C) 0.260413083 2.45E-16 0.361280195 p.(H38Q) 0.188140787 1.56E-52 1.315486452 p.(H38E) 0.342454743 4.26E-14 2.054274916 p.(H38G) 0.329297003 0.000156467 1.765090198 p.(H38H) 0.142815032 2.64E-28 0.198166193 p.(H38I) 0.391104565 5.27E-28 0.156950681 p.(H38L) 0.34147892 0.00024312 0.77577869 p.(H38K) 0.458052643 0 1.691483982 p.(H38M) 0.488080645 4.31E-84 0.543810964 p.(H38F) 0.513928009 5.84E-80 0.092985818 p.(H38P) 0.151597934 8.79E-07 0.30885901 p.(H38S) 0.557330208 1.11E-16 2.502178563 p.(H38T) 0.262892982 1.58E-14 1.313130679 p.(H38W) 0.454273038 2.13E-99 -0.524972224 p.(H38Y) 0.482966007 1.42E-65 -0.342777057 p.(H38V) 0.438137055 1.57E-39 1.232226776 p.(I11A) 0.2504803 4.53E-26 1.082019457 p.(I11R) 0.860715123 5.91E-57 -0.856813389 p.(I11N) 0.507979772 1.08E-58 1.300366773 p.(I11D) 0.418901012 8.59E-07 2.098320292 p.(I11C) 0.482144452 1.62E-14 1.645250215 p.(I11Q) 0.502211216 1.01E-19 0.152588615 p.(I11E) 0.620710743 1.11E-16 2.586759561 p.(I11G) 0.777759442 0 2.037116234 p.(I11H) 0.278962903 8.22E-43 0.070777136 p.(I11I) 0.239888508 5.55E-17 -0.159590219 p.(I11L) 0.652822078 8.81E-81 -0.337482129 p.(I11K) 0.681830396 8.21E-62 -0.688120524 p.(I11M) 0.452197877 2.22E-16 1.472875111 p.(I11F) 0.413534243 0 0.978623675 p.(I11P) 0.194364281 8.50E-86 0.394042829 p.(I11S) 0.968130174 8.88E-16 2.963044664 p.(I11T) 0.102370024 1.19E-45 0.742287729 p.(I11W) 0.255614638 3.77E-18 0.778576365 p.(I11Y) 0.460525074 2.85E-08 1.179149905 p.(I11V) 0.250002385 2.03E-40 1.684261606 p.(L21A) 0.103762866 2.38E-24 0.388138454 p.(L21R) 0.414416409 1.02E-10 0.535740623 p.(L21N) 0.518607357 5.22E-48 0.279772475 p.(L21D) 0.207789687 4.44E-16 0.926810705 p.(L21C) 0.718166414 1.37E-102 -0.142682418 p.(L21Q) 0.420621227 1.22E-42 0.507923027 p.(L21E) 0.886420382 8.88E-16 1.269801308 p.(L21G) 0.444481175 3.14E-92 0.742890002 p.(L21H) 0.397548733 4.58E-28 0.960322692 p.(L21I) 0.654275271 2.47E-73 0.153468662 p.(L21L) 0.246870614 1.93E-51 -0.368682952 p.(L21K) 0.789937734 2.22E-15 0.976941799 p.(L21M) 0.24775708 1.11E-16 -0.767304441 p.(L21F) 0.495219537 5.81E-60 0.457626453 p.(L21P) 0.103432467 3.54E-08 -0.044575053 p.(L21S) 0.31663345 6.75E-70 1.21273475 p.(L21T) 0.459560573 1.96E-64 0.46861884 p.(L21W) 1.127043397 8.57E-137 0.279891181 p.(L21Y) 0.506887354 6.12E-105 -0.235633847 p.(L21V) 0.657881905 6.55E-86 0.565035154 p.(K20A) 0.279983791 2.26E-35 1.004510173 p.(K20R) 0.310833711 3.15E-98 1.241828108 p.(K20N) 0.323363971 4.30E-31 1.410012129 p.(K20D) 0.671322281 1.11E-16 0.944577631 p.(K20C) 0.566814013 6.52E-75 0.439685925 p.(K20Q) 0.300080856 0 0.931212802 p.(K20E) 0.185400194 5.08E-06 0.685838509 p.(K20G) 0.417894347 3.25E-92 0.0591562 p.(K20H) 0.275251747 1.95E-39 1.164963545 p.(K20I) 0.657554296 7.31E-75 0.037215579 p.(K20L) 1.077026325 5.61E-45 -1.149312176 p.(K20K) 0.141439024 1.26E-59 0.34010622 p.(K20M) 0.445477028 0 0.613556602 p.(K20F) 1.175359882 2.22E-25 -0.368860228 p.(K20P) 0.605578057 1.61E-107 -0.058548112 p.(K20S) 1.054797147 5.68E-58 0.337875031 p.(K20T) 0.433253658 5.10E-26 0.115156329 p.(K20W) 1.008568922 1.66E-06 -1.791750607 p.(K20Y) 0.812673473 1.34E-97 -0.181803511 p.(K20V) 0.629561698 3.13E-116 -0.604147217 p.(K34A) 0.257864469 1.50E-35 1.631522048 p.(K34R) 0.236383781 0.000141616 1.144926212 p.(K34N) 0.574877085 0 1.77044036 p.(K34D) 0.672321045 0 2.392809985 p.(K34C) 0.533017624 3.21E-27 0.709711987 p.(K34Q) 0.447242262 0 0.835427204 p.(K34E) 0.657937916 4.44E-16 2.848543202 p.(K34G) 0.319530831 2.78E-17 1.756941471 p.(K34H) 0.255955784 2.81E-58 0.736641188 p.(K34I) 0.644434251 3.35E-50 0.555820484 p.(K34L) 0.384010533 9.13E-12 1.232569837 p.(K34M) 0.398809451 0 1.594315528 p.(K34F) 0.493799472 5.70E-72 0.117400781 p.(K34P) 0.409814678 0 2.009014268 p.(K34S) 0.284044445 1.08E-06 1.250084115 p.(K34T) 0.338552861 1.30E-12 1.366899009 p.(K34W) 0.89300524 1.63E-77 -0.266984034 p.(K34Y) 0.587347739 5.67E-57 -0.270492834 p.(K34V) 0.168140023 0 1.344039445 p.(K36A) 0.101020635 3.03E-08 1.193425549 p.(K36R) 0.360311971 7.61E-25 1.136859624 p.(K36N) 0.126050235 1.45E-10 -0.460514206 p.(K36D) 0.934855329 0 2.423716006 p.(K36C) 0.121971093 2.91E-06 1.044581169 p.(K36Q) 0.512833117 1.11E-16 1.775793901 p.(K36E) 0.245775054 1.06E-104 0.624297867 p.(K36G) 0.644126597 3.33E-16 0.700474491 p.(K36H) 0.425422152 0.002485444 0.496436847 p.(K36I) 0.149704351 5.93E-29 0.81087226 p.(K36L) 0.27106839 8.80E-60 0.81468759 p.(K36M) 0.399638033 5.27E-16 0.683359028 p.(K36F) 0.51539921 1.07E-83 0.515027115 p.(K36P) 0.342624759 2.34E-36 1.283778546 p.(K36S) 0.484382296 2.22E-16 1.242582953 p.(K36T) 0.420085013 1.18E-14 1.835311331 p.(K36W) 0.951321861 6.80E-39 -0.459476561 p.(K36Y) 0.926366616 3.26E-37 -0.601580006 p.(K36V) 0.429108952 1.72E-08 1.765894112 p.(M19A) 0.663540423 4.06E-28 0.479519158 p.(M19R) 0.635959683 7.93E-57 0.073524662 p.(M19N) 0.583560794 5.22E-119 0.364930368 p.(M19D) 0.293074472 1.10E-31 -0.126458772 p.(M19C) 0.330142545 7.63E-92 0.705804043 p.(M19Q) 0.468525005 1.53E-50 0.930565369 p.(M19E) 0.733730273 5.92E-08 0.254324326 p.(M19G) 0.427909808 7.32E-92 0.701945487 p.(M19H) 0.448189228 5.82E-50 0.245679744 p.(M19I) 0.25593272 0 1.2508081 p.(M19L) 0.318264896 3.84E-26 0.852258539 p.(M19K) 0.74135004 1.32E-80 0.163344035 p.(M19F) 0.608280836 1.31E-15 -0.850428875 p.(M19P) 0.450111173 1.23E-44 0.387708594 p.(M19S) 0.454810491 7.86E-26 0.397063829 p.(M19T) 0.360636778 1.81E-30 0.970454636 p.(M19W) 0.898551463 2.26E-96 -0.912287906 p.(M19Y) 0.665561826 3.10E-78 -0.140800106 p.(M19V) 0.168080066 1.77E-43 0.83308181 p.(M24A) 0.084369338 3.40E-35 1.265719681 p.(M24R) 0.437864866 1.59E-40 0.716951695 p.(M24N) 0.141142865 3.01E-51 0.523215661 p.(M24D) 0.288706556 9.71E-17 1.215845708 p.(M24C) 0.124728847 4.73E-74 0.203626793 p.(M24Q) 0.223770147 4.28E-08 1.720371408 p.(M24E) 0.51773019 2.22E-16 2.244799498 p.(M24G) 0.246128296 4.36E-28 2.221258538 p.(M24H) 0.296995793 0.000209836 1.465137318 p.(M24I) 0.299262168 0 1.13571204 p.(M24L) 0.245578836 2.79E-07 0.762420627 p.(M24K) 0.311891373 2.47E-09 0.901845382 p.(M24F) 0.405491122 1.35E-07 0.468810504 p.(M24P) 0.343034139 5.63E-07 1.492426913 p.(M24S) 0.176312732 2.60E-41 1.119678498 p.(M24T) 0.126634954 1.80E-50 1.169395714 p.(M24W) 0.791340039 5.58E-90 -0.641993094 p.(M24Y) 0.196180122 5.76E-10 0.312895265 p.(M24V) 0.269266495 1.44E-78 0.060351236 p.(F30A) 0.90432407 4.44E-16 3.715539419 p.(F30R) 0.824620603 8.88E-16 2.988292362 p.(F30N) 0.671186069 0 3.610947001 p.(F30D) 1.226496335 0 3.451398279 p.(F30C) 0.706392132 0 2.133766601 p.(F30Q) 0.261691677 3.57E-11 3.020259669 p.(F30E) 0.757468408 2.31E-06 2.372231527 p.(F30G) 0.424899147 5.55E-17 1.273592288 p.(F30H) 0.720452243 0 2.293989997 p.(F30I) 0.24048661 1.19E-81 1.198440879 p.(F30L) 0.393465881 0 1.601365498 p.(F30K) 0.690039083 4.44E-16 2.576284466 p.(F30M) 0.658022393 0 2.976489349 p.(F30P) 0.410085909 1.09E-09 2.412644578 p.(F30S) 0.28943845 7.66E-83 0.336127499 p.(F30T) 0.465794328 2.09E-10 3.18961268 p.(F30W) 0.6286145 3.55E-112 0.090463524 p.(F30Y) 0.365286602 0 0.892696788 p.(F30V) 0.461985024 0 2.869486799 p.(F47A) 0.386651062 1.89E-09 1.154904992 p.(F47R) 0.478247207 1.13E-05 1.207473261 p.(F47N) 2.254863862 0 -2.559730266 p.(F47D) 0.735699776 1.90E-25 -3.868678112 p.(F47C) 0.445829212 7.15E-08 1.267723856 p.(F47Q) 0.513895396 6.98E-37 -1.472236349 p.(F47E) 0.807020653 4.54E-18 -1.930446242 p.(F47G) 0.901933717 6.64E-31 -2.563706265 p.(F47H) 0.246649151 4.53E-05 0.219739266 p.(F47I) 0.096832888 5.08E-11 0.361184655 p.(F47L) 0.117556053 1.92E-29 1.518363998 p.(F47K) 0.408175962 1.39E-07 -0.098191489 p.(F47M) 0.397461416 0 1.466607553 p.(F47P) 0.716007088 1.18E-60 -3.626356271 p.(F47S) 0.266456853 2.46E-46 -0.47918449 p.(F47T) 0.565911034 3.09E-11 0.44512143 p.(F47W) 0.212325684 4.56E-63 -0.068513905 p.(F47Y) 0.476275745 3.72E-18 0.3076599 p.(F47V) 0.354613762 0 0.843739406 p.(S10A) 0.906687817 1.12E-36 -0.366360348 p.(S10R) 1.083358252 1.09E-53 -0.082580532 p.(S10N) 0.33396119 3.58E-15 0.356498364 p.(S10D) 0.241288966 3.47E-22 2.119015008 p.(S10C) 0.47398203 9.36E-12 0.144463241 p.(S10Q) 0.775552544 3.38E-65 -0.025096325 p.(S10E) 0.645661966 1.48E-72 0.625102492 p.(S10G) 0.50833546 5.14E-47 0.7899068 p.(S10H) 0.714338219 2.68E-34 -0.522706374 p.(S10I) 0.727367924 8.20E-12 -0.441659855 p.(S10L) 0.937236948 7.51E-70 -0.336958042 p.(S10K) 0.590156535 1.68E-97 -0.277844283 p.(S10M) 0.697050377 1.01E-11 0.557777458 p.(S10F) 0.891933374 1.37E-80 -0.722677266 p.(S10P) 0.248010203 2.67E-07 1.127239007 p.(S10S) 0.148458954 1.46E-34 0.990189617 p.(S10T) 0.676195624 4.04E-39 0.047795487 p.(S10W) 1.200674549 1.13E-52 -1.587458331 p.(S10Y) 0.648763446 3.92E-22 -1.347917459 p.(S10V) 1.081101593 5.12E-37 -0.319370729 p.(S13A) 0.63086176 0 0.944173184 p.(S13R) 0.730443325 1.39E-48 -0.482105972 p.(S13N) 0.491571253 3.08E-08 0.498078521 p.(S13D) 0.392086074 8.33E-17 0.705727378 p.(S13C) 0.307537214 1.32E-60 0.492229895 p.(S13Q) 0.186577516 8.33E-69 0.633951108 p.(S13E) 0.355770975 1.79E-11 0.976678876 p.(S13G) 0.354852517 2.61E-39 0.759741498 p.(S13H) 0.964713971 6.37E-64 -0.063952383 p.(S13I) 0.663476532 5.39E-12 0.359407777 p.(S13L) 1.191151613 1.38E-46 0.133281153 p.(S13K) 0.899061678 1.33E-64 -0.391378627 p.(S13M) 0.845763521 5.41E-16 0.243332812 p.(S13F) 0.612298909 2.65E-49 -0.787880364 p.(S13P) 0.510316345 1.48E-149 -0.542248592 p.(S13S) 0.378492133 0.000742252 1.492528989 p.(S13T) 0.528046975 0 0.513125011 p.(S13W) 1.013569423 1.68E-102 -0.32994131 p.(S13Y) 0.75630563 5.59E-88 0.039929254 p.(S13V) 0.808802014 2.09E-92 0.071088803 p.(S14A) 0.421797296 1.16E-13 1.014362349 p.(S14R) 0.262286517 8.55E-27 0.012842245 p.(S14N) 0.511558575 5.17E-111 0.105891182 p.(S14D) 0.380278567 5.10E-33 0.819626432 p.(S14C) 0.074053563 2.69E-66 0.800065217 p.(S14Q) 0.252322349 0.000727091 0.528185587 p.(S14E) 0.470229982 0 0.623856732 p.(S14G) 0.214858176 0 0.324649147 p.(S14H) 0.228755692 6.13E-08 -0.121983135 p.(S14I) 0.251017692 5.55E-17 -0.134303394 p.(S14L) 0.468432731 1.56E-07 0.788080897 p.(S14K) 0.3668245 5.89E-08 0.524169494 p.(S14M) 0.265916943 1.63E-12 1.517833275 p.(S14F) 0.717189079 3.07E-63 -0.37761348 p.(S14P) 0.155189276 1.12E-24 1.364102576 p.(S14S) 0.157079229 1.12E-15 -0.569147478 p.(S14T) 0.599689649 0 1.7966385 p.(S14W) 0.659210091 2.01E-78 -0.764912939 p.(S14Y) 0.689468966 3.33E-98 -0.18821222 p.(S14V) 0.406636926 1.39E-16 1.222225132 p.(S35A) 0.264195316 3.03E-38 1.022507698 p.(S35R) 0.314749751 2.55E-38 0.84006026 p.(S35N) 0.434117938 0 -0.036129756 p.(S35D) 0.336618564 4.24E-153 2.054124514 p.(S35C) 0.410425926 1.61E-14 0.143024872 p.(S35Q) 0.54251952 2.94E-43 0.562468172 p.(S35E) 1.20150882 2.66E-15 3.32315039 p.(S35G) 0.797362418 1.42E-39 0.357874868 p.(S35H) 0.417386636 9.98E-100 0.454764982 p.(S35I) 0.538756007 1.65E-116 0.344902002 p.(S35L) 0.326092433 1.34E-103 0.163206526 p.(S35K) 0.621124511 0 1.48037386 p.(S35M) 0.41552701 4.39E-24 0.423526324 p.(S35F) 0.429119837 2.85E-82 0.008465203 p.(S35P) 0.311667936 1.27E-83 0.774362553 p.(S35S) 0.370877621 1.82E-09 0.761011871 p.(S35T) 0.4447274 3.31E-60 0.409932578 p.(S35W) 0.823240588 8.48E-60 0.017642544 p.(S35Y) 0.397418059 4.62E-63 -0.627860575 p.(S35V) 0.506323047 2.84E-47 0.863164695 p.(S3A) 0.646391333 6.47E-77 0.420316928 p.(S3R) 1.047373167 1.47E-06 -1.630094905 p.(S3N) 0.455890907 1.55E-69 -0.067894595 p.(S3D) 0.49436088 0 1.35518421 p.(S3C) 1.402155539 2.94E-60 -1.653044106 p.(S3Q) 0.433104883 5.95E-60 0.13040311 p.(S3E) 0.254141784 0.000135097 2.124911499 p.(S3G) 0.589240627 1.17E-36 -0.012927562 p.(S3H) 0.653688385 1.08E-78 -0.258749864 p.(S3I) 0.914804827 1.40E-42 -1.620313103 p.(S3L) 0.786773004 6.47E-50 -1.027169388 p.(S3K) 0.647483826 1.96E-43 -0.755410388 p.(S3M) 0.840407414 9.07E-86 -0.248497947 p.(S3F) 1.157457567 7.38E-91 -1.684258947 p.(S3P) 0.818927236 3.15E-86 -0.284497332 p.(S3T) 0.560602605 2.18E-131 -0.096054611 p.(S3W) 1.302236078 9.09E-82 -1.832738331 p.(S3Y) 0.870641665 3.60E-116 -1.301257118 p.(S3V) 0.758851273 4.13E-134 -1.022737688 p.(S45A) 0.495090239 0 0.484888706 p.(S45R) 1.51321501 3.55E-15 1.252253992 p.(S45N) 0.32254906 3.75E-86 1.509074297 p.(S45D) 0.391326094 0 1.57223982 p.(S45C) 1.009104376 4.56E-76 -0.110778178 p.(S45Q) 0.288334031 1.54E-11 1.844231828 p.(S45E) 0.135145875 0.000378899 1.185555505 p.(S45G) 0.44484604 2.44E-37 0.848810068 p.(S45H) 0.510426121 2.11E-15 1.870173886 p.(S45I) 0.738514471 4.74E-30 -0.818410521 p.(S45L) 0.838375629 1.06E-96 -0.014200875 p.(S45K) 0.454519746 0.002345358 0.528243079 p.(S45M) 0.795279452 1.41E-57 -0.060938184 p.(S45F) 0.769068518 2.95E-63 0.053170789 p.(S45P) 0.489245719 5.19E-26 0.298726429 p.(S45S) 0.095012932 6.85E-14 1.093265592 p.(S45T) 0.058550957 2.07E-44 0.788550205 p.(S45W) 0.636576266 5.36E-90 -0.34282377 p.(S45Y) 0.629272083 6.17E-79 0.516955061 p.(S45V) 1.092294394 1.44E-87 -0.347443509 p.(T23A) 0.501357271 5.01E-10 0.64769151 p.(T23R) 0.744770788 4.65E-52 0.163384803 p.(T23N) 0.368013018 3.01E-07 0.722321555 p.(T23D) 0.995560434 0 3.209873656 p.(T23C) 0.874972966 4.94E-53 -0.132028799 p.(T23Q) 0.305353502 1.95E-57 0.676564077 p.(T23E) 0.337183694 8.02E-12 2.02636056 p.(T23G) 0.496610619 6.15E-35 0.210315157 p.(T23H) 0.613931379 1.94E-67 0.709151805 p.(T23I) 0.529436237 4.93E-25 -1.476234241 p.(T23L) 0.497418562 8.19E-124 -2.86906545 p.(T23K) 0.27957044 2.33E-48 -0.045136188 p.(T23M) 0.833317491 9.54E-75 -0.885461916 p.(T23F) 0.80351561 0.000106781 0.102492667 p.(T23P) 0.206265855 4.05E-17 0.351866319 p.(T23S) 0.369751274 1.36E-11 1.616312508 p.(T23T) 0.30478816 1.53E-38 1.245436886 p.(T23W) 0.890810603 6.50E-42 0.147114178 p.(T23Y) 1.263914205 1.27E-53 -0.209760469 p.(T23V) 0.604100552 2.24E-68 -0.968376997 p.(T39A) 0.209002834 1.19E-06 0.435714743 p.(T39R) 0.313372982 4.98E-13 0.18059451 p.(T39N) 0.330746558 1.74E-07 0.942864927 p.(T39D) 0.397257782 1.46E-53 1.482794726 p.(T39C) 0.564142885 2.43E-64 0.307476649 p.(T39Q) 0.216182498 6.28E-11 0.638597399 p.(T39E) 0.430459456 6.63E-19 1.288418326 p.(T39G) 0.163408775 3.07E-30 0.770859276 p.(T39H) 0.194576337 6.04E-58 0.297827474 p.(T39I) 0.753707054 1.96E-48 0.488460786 p.(T39L) 0.435777861 1.36E-34 0.032639531 p.(T39K) 0.249133592 1.99E-44 0.664134424 p.(T39M) 0.674237521 4.09E-76 0.269035409 p.(T39F) 0.574494168 2.55E-70 -0.338144998 p.(T39P) 0.324382675 8.44E-09 0.97468045 p.(T39S) 0.234211681 0.00034455 0.913643489 p.(T39T) 0.106833957 5.94E-38 -0.101193774 p.(T39W) 0.921821215 1.64E-65 -0.78153713 p.(T39Y) 0.613087207 1.84E-54 -0.234925493 p.(T39V) 0.123648822 1.92E-12 0.202279308 p.(T6A) 0.048188549 1.03E-49 0.339668325 p.(T6R) 0.226563864 2.17E-15 1.296896335 p.(T6N) 0.619621924 0 0.87542512 p.(T6D) 0.871733678 0 1.75232857 p.(T6C) 0.559526066 1.42E-60 -0.179513982 p.(T6Q) 0.42573289 3.33E-16 1.210452853 p.(T6E) 0.809424653 0 2.604599302 p.(T6G) 0.342601733 6.11E-64 0.1101354 p.(T6H) 0.376300583 4.52E-86 0.283859589 p.(T6I) 0.830829112 1.11E-66 0.194690876 p.(T6L) 0.337119199 1.76E-12 1.090855273 p.(T6K) 0.460029376 2.03E-43 -0.263077296 p.(T6M) 0.133925901 6.33E-27 -0.187282876 p.(T6F) 0.803769376 1.65E-150 -0.259135535 p.(T6P) 0.297045834 0 1.286197009 p.(T6S) 0.415644348 3.91E-13 1.868898719 p.(T6W) 1.222280266 5.90E-80 -0.438075396 p.(T6Y) 0.573681387 1.05E-35 -0.916789727 p.(T6V) 0.557782798 2.00E-70 0.354362825 p.(Y9A) 0.936572236 0 3.020521099 p.(Y9R) 0.535386134 2.22E-16 1.304114701 p.(Y9N) 0.618428746 0 3.471870301 p.(Y9D) 0.481880673 5.47E-19 3.415329218 p.(Y9C) 0.249490987 1.57E-47 0.892818779 p.(Y9Q) 0.46205055 2.37E-16 1.556474517 p.(Y9E) 0.861608264 0 3.094184575 p.(Y9G) 0.234389263 8.02E-32 2.835515749 p.(Y9H) 0.284260284 2.51E-46 0.915717374 p.(Y9I) 0.476403946 2.22E-16 1.660163067 p.(Y9L) 0.413205413 5.01E-08 1.476217184 p.(Y9K) 0.313525381 7.87E-08 1.345866481 p.(Y9M) 0.444388734 0 1.660965771 p.(Y9F) 0.279464268 5.58E-13 2.039628134 p.(Y9P) 0.383495451 0 2.677692896 p.(Y9S) 0.250257282 3.41E-49 2.323244911 p.(Y9T) 0.362828806 0.001245598 2.568417298 p.(Y9W) 0.533059081 9.99E-81 0.634920566 p.(Y9Y) 0.267444825 5.55E-17 0.033649803 p.(Y9V) 0.286275522 0 1.982064306 p.(V12A) 0.677455837 0 2.102186489 p.(V12R) 0.330830044 0.00056616 1.182083935 p.(V12N) 0.303446632 7.35E-11 2.112401903 p.(V12D) 0.515473175 4.91E-12 2.778764769 p.(V12C) 0.167783441 2.93E-80 2.079332324 p.(V12Q) 0.231795137 1.35E-06 0.905927374 p.(V12E) 0.665938223 0 3.42550373 p.(V12G) 0.542138909 3.33E-16 3.086697291 p.(V12H) 0.291167378 0 1.153408007 p.(V12I) 0.864093613 2.35E-91 -0.944393469 p.(V12L) 1.173896578 9.16E-84 -2.459656447 p.(V12K) 0.233039957 1.38E-53 0.895956753 p.(V12M) 1.273911125 3.59E-11 -1.830325418 p.(V12F) 1.013177496 0.000261271 -1.922779436 p.(V12P) 0.215100833 4.45E-05 1.194457528 p.(V12S) 0.269913624 0.003019244 2.846827254 p.(V12T) 0.24457241 1.21E-07 2.955971174 p.(V12W) 1.238803959 1.05E-40 -0.54464654 p.(V12Y) 0.759400881 3.59E-89 0.046870687 p.(V12V) 1.194349562 0 0.781665728 p.(V26A) 0.528643561 0 2.043184615 p.(V26R) 0.479499165 1.03E-09 1.07653998 p.(V26N) 0.363050238 5.48E-06 0.987137223 p.(V26D) 0.425372135 1.29E-10 3.024992603 p.(V26C) 0.476021907 0.002670791 1.729396099 p.(V26Q) 0.181371324 3.14E-37 1.402379671 p.(V26E) 0.625703286 0 1.947835468 p.(V26G) 0.683469947 3.33E-16 1.470586931 p.(V26H) 0.536523589 5.55E-17 1.647051343 p.(V26I) 0.371395574 2.39E-08 0.360112749 p.(V26L) 0.285335422 1.62E-50 0.306666079 p.(V26K) 0.461467175 1.10E-14 1.700716722 p.(V26M) 0.538132092 5.29E-26 0.472752468 p.(V26F) 1.020077241 3.03E-84 -0.760232246 p.(V26P) 0.108235398 8.43E-09 2.361526277 p.(V26S) 0.271464014 1.92E-09 1.623267117 p.(V26T) 0.127410287 4.81E-49 0.686616236 p.(V26W) 1.093311071 7.20E-41 -0.560028846 p.(V26Y) 0.138294176 3.75E-45 0.512900036 p.(V26V) 0.132651146 6.94E-18 -0.249084878 p.(V37A) 0.209929305 5.55E-17 0.762708339 p.(V37R) 0.473139491 1.69E-21 1.166136602 p.(V37N) 0.234180815 0 0.516210317 p.(V37D) 0.411808195 1.53E-08 1.729639361 p.(V37C) 0.62215208 4.52E-08 -0.209472855 p.(V37Q) 0.339829197 7.39E-11 0.403220696 p.(V37E) 0.758592371 4.44E-16 2.44798068 p.(V37G) 0.247377846 9.89E-06 0.943251497 p.(V37H) 0.216797001 5.85E-86 0.345936816 p.(V37I) 0.449131259 6.48E-50 0.533587114 p.(V37L) 0.553388152 3.36E-50 0.558703918 p.(V37K) 0.465350022 1.11E-16 1.541508481 p.(V37M) 0.169311896 0.0002332 0.138313283 p.(V37F) 0.370333913 1.18E-13 -0.390610399 p.(V37P) 0.185004393 3.30E-151 0.963038408 p.(V37S) 0.328547559 1.62E-18 1.20581149 p.(V37T) 0.26082602 0 1.111661596 p.(V37W) 0.833605103 7.21E-90 -0.306505097 p.(V37Y) 0.420722871 3.76E-77 -0.026815378 p.(V37V) 0.363276362 0 0.208166367 p.(V48A) 0.595430598 4.64E-60 0.271574929 p.(V48R) 1.687494284 0 -2.690997725 p.(V48N) 1.304398801 8.88E-16 -2.026035348 p.(V48D) 0.291740208 9.17E-59 -4.468408537 p.(V48C) 0.299592572 2.32E-82 0.869874451 p.(V48Q) 0.503463469 2.89E-35 0.137762939 p.(V48E) 1.038968844 1.64E-10 -2.995905153 p.(V48G) 1.394260151 0 -3.862972818 p.(V48H) 0.703382642 5.83E-86 -0.988000795 p.(V48I) 0.567710958 1.36E-69 0.367148198 p.(V48L) 0.402654613 2.49E-10 0.497661956 p.(V48K) 0.712085163 2.96E-16 -3.341557509 p.(V48M) 0.290918339 5.32E-55 0.279990402 p.(V48F) 0.417207257 5.40E-30 0.634125446 p.(V48P) 0.652991229 1.36E-16 -3.577979915 p.(V48S) 0.657078756 3.67E-54 -1.54771252 p.(V48T) 0.445823149 5.55E-17 0.359441278 p.(V48W) 0.442144262 5.82E-06 -0.173080469 p.(V48Y) 0.612449221 2.20E-08 0.681201391 p.(V48V) 0.14640448 5.14E-26 0.540884164 p.(V4A) 0.18588633 0.000631822 0.338540675 p.(V4R) 0.480206526 1.77E-105 0.276799476 p.(V4N) 0.698443154 4.44E-16 0.869917262 p.(V4D) 0.368049195 3.69E-65 1.958637163 p.(V4C) 1.040810466 1.64E-40 -0.320916526 p.(V4Q) 0.396950279 0 0.899441594 p.(V4E) 0.517491213 0 0.738737766 p.(V4G) 0.380453275 5.07E-15 0.346887274 p.(V4H) 0.407870312 2.87E-35 0.368131369 p.(V4I) 0.399116094 0 0.996171725 p.(V4L) 0.338371864 2.77E-72 0.494782971 p.(V4K) 0.191039469 1.27E-12 0.260515575 p.(V4M) 0.185801685 1.38E-48 -0.436638851 p.(V4F) 0.503904963 2.34E-48 -0.5717488 p.(V4P) 0.260343392 3.02E-14 2.410772376 p.(V4S) 0.48407003 0 1.624201049 p.(V4T) 0.30907606 1.78E-08 1.614466546 p.(V4W) 0.927308514 8.29E-94 -0.878493967 p.(V4Y) 0.698455419 1.73E-98 -0.332439772 p.(V4V) 0.156099358 1.10E-07 -0.141642586 p.(A70A) 0.145539209 0.00042677 -0.393198132 p.(A70R) 0.68984988 0 2.311017502 p.(A70N) 0.578433447 3.06E-31 0.206914284 p.(A70D) 0.62600371 2.48E-17 0.07383739 p.(A70C) 0.340432307 3.83E-101 1.457232031 p.(A70Q) 0.493194036 1.52E-17 0.830724594 p.(A70E) 0.857667447 1.10E-54 -0.531292739 p.(A70G) 0.606697813 1.31E-55 0.591031827 p.(A70H) 0.551232425 2.68E-59 0.273702587 p.(A70I) 0.950110336 2.60E-11 -1.306136545 p.(A70L) 0.42221754 2.93E-73 -0.314075871 p.(A70K) 0.323779488 8.80E-15 2.265257892 p.(A70M) 0.533317992 6.75E-26 0.028810893 p.(A70F) 0.58996461 3.50E-69 -0.362007877 p.(A70P) 0.368898465 0 0.348719278 p.(A70S) 0.409894693 4.06E-49 1.131669902 p.(A70T) 0.194052516 0 -0.623080169 p.(A70W) 0.993400144 5.00E-45 -0.200960975 p.(A70Y) 0.809617348 1.89E-78 -0.71734199 p.(A70V) 1.18711919 1.91E-07 -1.009778488 p.(A91A) 0.226310557 3.23E-33 0.040424911 p.(A91R) 0.930023952 6.13E-15 -0.617249798 p.(A91N) 0.318465262 6.59E-23 1.755167119 p.(A91D) 0.43892405 5.55E-17 -1.286757387 p.(A91C) 0.948134419 9.45E-62 -0.254864989 p.(A91Q) 0.508001865 6.61E-06 1.475781093 p.(A91E) 0.726784875 1.28E-41 -0.34092942 p.(A91G) 0.570274212 0 1.202756514 p.(A91H) 0.886898976 1.33E-20 0.447609654 p.(A91I) 0.354116542 9.38E-29 0.46543888 p.(A91L) 0.357573401 1.86E-08 1.392417154 p.(A91K) 0.813470974 1.40E-24 0.396697408 p.(A91M) 0.159723863 9.43E-39 0.99299556 p.(A91F) 0.446668575 2.56E-65 0.824173276 p.(A91P) 0.993026337 1.52E-42 -2.349348459 p.(A91S) 0.495705874 7.17E-82 0.205590247 p.(A91T) 0.202413318 3.51E-42 -0.810935336 p.(A91W) 0.956896297 4.44E-16 2.787490247 p.(A91Y) 0.69154941 4.44E-16 3.223608191 p.(A91V) 0.366175357 2.16E-37 -0.445469689 p.(R67A) 0.636162259 4.69E-58 -0.174219103 p.(R67N) 0.658865894 6.02E-12 0.975012252 p.(R67D) 0.62729107 9.01E-50 -0.132685207 p.(R67C) 0.471861288 2.22E-16 0.657863234 p.(R67Q) 0.320944702 1.02E-51 -0.680420631 p.(R67E) 0.723032206 4.72E-80 -0.436792923 p.(R67G) 0.639699318 1.90E-43 0.109233984 p.(R67H) 0.672504692 9.54E-55 -0.303148199 p.(R67I) 0.624498799 8.79E-39 -0.962705489 p.(R67L) 1.090754046 3.58E-33 -0.318162116 p.(R67K) 0.242633852 3.18E-30 0.820726657 p.(R67M) 0.873958113 3.49E-87 -0.038708917 p.(R67F) 0.77840249 4.35E-123 -0.080435964 p.(R67P) 0.638277481 6.59E-131 -0.242029242 p.(R67S) 0.635145966 2.09E-95 0.023873007 p.(R67T) 0.870755906 4.23E-25 -0.467496054 p.(R67W) 0.162706262 6.42E-28 -1.078804082 p.(R67Y) 0.862227941 3.74E-63 -0.723288694 p.(R67V) 1.033710705 1.04E-99 -2.358768511 p.(R80A) 0.770112259 4.35E-19 -0.463347752 p.(R80R) 0.466918069 6.17E-102 0.809235977 p.(R80N) 1.152584534 0 2.941608288 p.(R80D) 1.035084676 0 2.381914991 p.(R80C) 0.466343082 2.48E-75 -1.138008407 p.(R80Q) 0.027612207 4.92E-64 0.036673092 p.(R80E) 0.53220507 1.95E-54 -0.263611958 p.(R80G) 0.634619544 1.53E-79 -0.674987051 p.(R80H) 0.555811282 8.09E-70 -0.179153569 p.(R80I) 0.788656986 8.11E-21 -0.222040655 p.(R80L) 0.878936631 1.99E-65 -0.356150703 p.(R80K) 0.487104745 0 1.21311156 p.(R80M) 0.694083894 7.78E-33 0.031131947 p.(R80F) 1.212467716 7.10E-62 0.037291121 p.(R80P) 0.598172662 0 1.157261782 p.(R80S) 0.922587582 7.05E-43 -0.487429414 p.(R80T) 0.799068305 2.09E-26 -1.044749782 p.(R80W) 0.545108492 7.52E-49 -0.966626068 p.(R80Y) 0.657858492 1.44E-31 -1.832953033 p.(R80V) 0.961030337 2.73E-67 -0.271120538 p.(R82A) 0.357813466 9.22E-05 0.203874105 p.(R82R) 0.281261428 1.55E-06 0.958585385 p.(R82N) 0.804630601 1.60E-63 -0.883468356 p.(R82D) 1.381322685 1.84E-09 -1.057806734 p.(R82C) 0.307600724 0 -0.550818826 p.(R82Q) 0.640422748 1.11E-16 0.427003747 p.(R82E) 0.281154517 1.68E-09 0.534985955 p.(R82G) 0.551528835 2.77E-13 0.471716023 p.(R82H) 0.267144376 0 -1.063174405 p.(R82I) 0.327962248 5.66E-58 1.734921293 p.(R82L) 0.297195143 4.36E-22 0.200608877 p.(R82K) 0.351852092 2.39E-09 -0.557029724 p.(R82M) 0.463196143 7.82E-07 2.774289691 p.(R82F) 0.589752199 0 0.530651747 p.(R82P) 0.394436419 1.08E-11 1.023400562 p.(R82S) 0.833324917 3.49E-72 -0.23138263 p.(R82T) 0.507297028 6.10E-67 -0.066899497 p.(R82W) 0.32496438 6.13E-44 0.574359611 p.(R82Y) 0.555397008 0 3.783910026 p.(R82V) 0.39454776 0.001477494 2.144609873 p.(N55A) 0.219902524 0.000149953 0.710424902 p.(N55R) 0.580539429 7.33E-38 0.289887463 p.(N55N) 0.239329239 1.67E-13 0.470476028 p.(N55D) 0.310232236 0.002002246 1.818054163 p.(N55C) 0.634187328 2.38E-28 -0.250694614 p.(N55Q) 0.340499009 1.54E-06 1.446735419 p.(N55E) 0.61451714 0 1.697933119 p.(N55G) 0.606926863 7.15E-59 0.136062321 p.(N55H) 0.690294239 7.77E-18 -0.422226805 p.(N55I) 0.759248722 4.46E-53 -0.864687156 p.(N55L) 0.696873482 2.05E-56 -0.527203255 p.(N55K) 0.288343449 3.54E-54 0.773804322 p.(N55M) 1.097423577 3.17E-44 0.020337978 p.(N55F) 0.824033422 6.17E-27 -1.309609669 p.(N55P) 0.575643885 0 0.498886139 p.(N55S) 0.289877513 7.00E-11 1.305500553 p.(N55T) 0.408688201 1.55E-10 1.003221955 p.(N55W) 0.634530822 2.30E-20 -3.606130528 p.(N55Y) 0.822553118 3.10E-46 -1.560253811 p.(N55V) 0.820538989 3.98E-50 -0.752009042 p.(N60A) 0.461355974 5.55E-17 0.683932384 p.(N60R) 0.076656259 4.10E-48 1.240790883 p.(N60N) 0.174546678 1.39E-17 0.075169938 p.(N60D) 0.200657136 1.81E-10 0.49983799 p.(N60C) 0.976983463 1.20E-48 -0.262844478 p.(N60Q) 0.398324908 3.09E-06 0.953992279 p.(N60E) 0.429151215 0 1.138068739 p.(N60G) 0.466519257 5.73E-36 0.655678331 p.(N60H) 0.551740184 5.39E-13 0.565183389 p.(N60I) 0.798024206 5.60E-51 -1.025828961 p.(N60L) 0.763386353 7.15E-74 -0.414945327 p.(N60K) 0.309515822 9.68E-26 0.29951391 p.(N60M) 0.885571106 3.37E-75 -0.092486154 p.(N60F) 0.860946735 1.11E-50 -0.271086508 p.(N60P) 0.43361417 4.32E-10 0.592739177 p.(N60S) 0.212714848 8.58E-28 1.474722712 p.(N60T) 0.427670357 2.44E-38 0.046721095 p.(N60W) 1.070583366 2.32E-60 -0.07542316 p.(N60Y) 1.060637624 3.31E-98 -0.348960895 p.(N60V) 0.892598014 4.36E-93 -0.304562339 p.(D51A) 0.491725472 1.49E-42 1.021033551 p.(D51R) 0.28131963 2.59E-92 0.01228996 p.(D51N) 0.299751837 0.00069149 0.450382523 p.(D51C) 0.641322877 1.80E-61 -0.285418975 p.(D51Q) 0.234097723 2.68E-14 0.235715184 p.(D51E) 0.362349087 1.13E-07 1.573973986 p.(D51G) 0.101408651 5.65E-10 -0.084280238 p.(D51H) 0.441603515 3.30E-98 0.836685218 p.(D51I) 1.197947763 2.09E-13 -0.80151494 p.(D51L) 1.034050139 4.46E-26 -0.841677776 p.(D51K) 0.336566209 6.48E-59 1.080640727 p.(D51M) 0.484177925 1.04E-44 -0.149849298 p.(D51F) 0.788260882 8.59E-33 -0.907814129 p.(D51P) 0.841170211 5.46E-50 -0.666433588 p.(D51S) 0.345377871 5.88E-20 -0.05561766 p.(D51T) 0.294715478 7.15E-76 0.424122692 p.(D51W) 0.782364044 2.89E-37 -2.284846048 p.(D51Y) 0.556257618 0.00216416 -0.860269695 p.(D51V) 0.808731752 1.01E-59 -0.778907249 p.(D71A) 0.293482359 7.06E-07 1.026163714 p.(D71R) 1.094604074 0 2.693619681 p.(D71N) 1.08487254 8.88E-16 2.591372661 p.(D71C) 0.781731952 4.32E-49 0.183774739 p.(D71Q) 1.22212874 8.88E-16 2.330358738 p.(D71E) 0.509243971 0 1.507251718 p.(D71G) 0.405439823 2.08E-121 1.280067248 p.(D71H) 0.283498029 2.31E-71 0.638744626 p.(D71I) 0.692391301 0.004847983 -0.112089289 p.(D71L) 1.028593254 1.69E-47 -0.310642548 p.(D71K) 0.328700309 1.11E-47 1.913142469 p.(D71M) 0.745331619 3.91E-83 -0.117997344 p.(D71F) 1.167389821 1.25E-71 -0.19485863 p.(D71P) 0.435796265 1.60E-05 1.270570764 p.(D71S) 0.411720881 0.000595129 1.988360115 p.(D71T) 0.296115996 1.45E-16 1.262613948 p.(D71W) 0.545911937 3.46E-46 1.044777811 p.(D71Y) 0.973241138 3.07E-09 -0.43675618 p.(D71V) 0.966139861 5.12E-05 -0.112537487 p.(D78A) 0.637660869 0 2.030867087 p.(D78R) 0.760339851 2.22E-16 2.696167558 p.(D78N) 0.269315137 3.80E-41 0.297284721 p.(D78D) 0.204559539 0 0.881773898 p.(D78C) 0.446857392 9.84E-37 0.756739613 p.(D78Q) 1.349803589 0 3.088681535 p.(D78E) 0.263177353 2.54E-09 0.994036013 p.(D78G) 0.366306213 8.25E-55 0.67565432 p.(D78H) 0.151499605 1.51E-13 1.422539482 p.(D78I) 0.703268878 2.39E-77 -0.027457813 p.(D78L) 0.45288722 2.25E-12 1.036425599 p.(D78K) 0.448961408 1.58E-11 0.9982809 p.(D78M) 0.328915618 1.58E-74 1.367450592 p.(D78F) 0.167490732 2.70E-59 0.195354473 p.(D78P) 0.299292215 7.14E-49 0.432094818 p.(D78S) 0.698290042 0 1.82062226 p.(D78T) 0.315433737 4.33E-08 1.753133812 p.(D78W) 0.704705003 1.22E-15 0.424170741 p.(D78Y) 0.321020993 0 -0.246291683 p.(D78V) 0.308962407 2.25E-74 0.416035494 p.(C54A) 0.477391901 1.67E-16 1.17516341 p.(C54R) 0.760006162 0 2.334574221 p.(C54N) 0.302843886 1.15E-11 0.281892687 p.(C54D) 0.894422575 4.44E-16 1.826016749 p.(C54C) 0.166322488 2.78E-17 0.414637241 p.(C54Q) 0.137419323 0.0003888 0.495611611 p.(C54E) 1.039240656 0 2.38033574 p.(C54G) 0.234160211 5.34E-27 1.887943209 p.(C54H) 0.520628459 0.000458916 1.456095858 p.(C54I) 0.799080082 9.83E-75 0.083445028 p.(C54L) 0.737704019 7.97E-92 0.061378935 p.(C54K) 0.962759211 4.44E-16 3.000572551 p.(C54M) 0.592926948 1.42E-17 0.563368223 p.(C54F) 0.401574603 2.40E-75 0.4996117 p.(C54P) 0.57210084 3.33E-16 1.652597547 p.(C54S) 0.325350758 0 1.192179671 p.(C54T) 0.344805842 3.87E-17 0.622684352 p.(C54W) 0.339383468 1.11E-26 -0.155887883 p.(C54Y) 0.126181493 4.46E-08 -0.552334793 p.(C54V) 0.360260374 3.29E-115 0.445016035 p.(C76A) 0.302778259 1.03E-10 0.909965994 p.(C76R) 0.501140946 1.33E-47 1.045312264 p.(C76N) 0.659017746 0 1.094080416 p.(C76D) 0.487801342 0.000181652 -0.411223139 p.(C76Q) 0.410663191 5.67E-23 0.354865309 p.(C76E) 0.401732242 1.80E-66 0.600918955 p.(C76G) 0.500000622 1.56E-10 1.824040545 p.(C76H) 0.393679773 5.75E-91 0.254568782 p.(C76I) 0.623737009 2.22E-16 2.34516942 p.(C76L) 0.257363989 2.74E-13 1.414515212 p.(C76K) 0.462226135 9.55E-23 1.082654927 p.(C76M) 0.353921189 6.42E-33 0.33407638 p.(C76F) 0.317452172 5.06E-18 1.615119075 p.(C76P) 0.318594881 1.19E-11 1.587638912 p.(C76S) 0.408454256 1.49E-19 1.468587262 p.(C76T) 0.555046079 5.44E-35 0.887779 p.(C76W) 0.201741122 6.62E-08 0.716184371 p.(C76Y) 0.58754795 8.03E-157 -0.231857812 p.(C76V) 0.407461826 1.08E-12 0.678921605 p.(C89A) 0.516891909 2.15E-89 -0.058474702 p.(C89R) 0.409958947 2.73E-36 -3.561704872 p.(C89N) 1.095024091 1.33E-07 1.202093249 p.(C89D) 1.1601634 1.61E-74 -2.445637806 p.(C89C) 0.179828375 9.50E-10 0.270063347 p.(C89Q) 1.063395824 1.63E-145 -0.257627968 p.(C89E) 1.123322751 1.33E-36 -2.076579487 p.(C89G) 1.117013137 2.33E-73 -0.128323372 p.(C89H) 0.900742075 7.15E-34 -1.073640541 p.(C89I) 1.164019914 0 1.534237105 p.(C89L) 0.265330326 3.05E-05 1.396420625 p.(C89K) 0.699464335 3.41E-27 -0.251170731 p.(C89M) 0.715882809 4.44E-16 1.791807027 p.(C89F) 0.228888189 7.87E-38 -0.469250856 p.(C89P) 0.460449972 1.24E-26 0.85065151 p.(C89S) 0.805853589 1.05E-56 -0.35537378 p.(C89T) 0.686909956 7.40E-118 0.140239485 p.(C89W) 1.006243292 9.50E-49 -0.414648136 p.(C89Y) 0.957797821 1.77E-11 -2.081281346 p.(C89V) 0.434427255 1.81E-14 1.453774539 p.(Q57A) 0.693148324 6.58E-54 0.739288034 p.(Q57R) 0.29489053 9.63E-05 1.309502165 p.(Q57N) 0.065537696 3.55E-18 1.314763422 p.(Q57D) 0.586482236 1.11E-16 2.130750906 p.(Q57C) 0.646155651 3.90E-51 0.178387169 p.(Q57E) 0.436424769 1.11E-16 1.594158334 p.(Q57G) 1.273544772 0 1.84509404 p.(Q57H) 0.761022492 0 0.199422601 p.(Q57I) 1.057890048 2.91E-42 -0.519233651 p.(Q57L) 0.800825085 5.83E-61 -0.524138061 p.(Q57K) 0.369850201 2.27E-08 1.0110685 p.(Q57M) 0.917844959 1.17E-75 -0.332028441 p.(Q57F) 1.035221792 2.28E-110 -0.092648989 p.(Q57P) 0.935825961 4.16E-86 -0.893227785 p.(Q57S) 0.358768814 1.04E-26 1.005058838 p.(Q57T) 0.497166043 1.11E-16 0.505371944 p.(Q57W) 0.75986959 1.85E-58 -0.414056447 p.(Q57Y) 1.018543977 1.56E-05 -0.107239298 p.(Q57V) 1.156413875 1.35E-39 -0.155059353 p.(Q66A) 0.197670785 7.80E-69 0.279782938 p.(Q66R) 0.297611531 0.000122012 3.64491798 p.(Q66N) 0.863364139 0 1.447351701 p.(Q66D) 0.457116092 6.28E-53 -0.20388748 p.(Q66C) 0.331993815 1.73E-63 2.309534366 p.(Q66E) 0.84369529 3.01E-95 -0.418850354 p.(Q66G) 0.423147111 8.91E-81 0.012389508 p.(Q66H) 0.556616266 0 1.191149797 p.(Q66I) 0.42338646 1.23E-39 1.260500936 p.(Q66L) 0.295513309 3.25E-11 1.532509469 p.(Q66K) 0.217423989 1.32E-11 3.069806814 p.(Q66M) 0.355187976 1.29E-17 1.726906256 p.(Q66F) 0.363738494 1.15E-29 1.281303097 p.(Q66P) 0.69356187 4.44E-16 0.046558419 p.(Q66S) 0.519982645 0 1.005448965 p.(Q66T) 0.279304582 9.52E-84 0.927194399 p.(Q66W) 0.46679329 2.22E-16 2.962437864 p.(Q66Y) 0.558715242 5.61E-15 0.640673877 p.(Q66V) 0.355858115 1.10E-09 0.373470774 p.(E63A) 0.414486395 6.19E-55 1.338468642 p.(E63R) 0.790923412 0 2.456489095 p.(E63N) 0.238770718 3.46E-08 2.28689191 p.(E63D) 0.271242231 2.63E-24 0.114053309 p.(E63C) 0.195069438 0.000173679 2.550676888 p.(E63Q) 0.330618159 1.75E-10 1.638598533 p.(E63E) 0.156790976 2.78E-09 0.111858232 p.(E63G) 0.323629943 0 1.129931537 p.(E63H) 0.206039296 2.48E-22 1.544627917 p.(E63I) 0.217640965 1.40E-40 1.090976369 p.(E63L) 0.300424755 3.97E-09 1.340557254 p.(E63K) 0.908574251 0 3.203931807 p.(E63M) 0.241371754 0.000142595 0.169833419 p.(E63F) 0.281992888 7.37E-38 0.122881616 p.(E63P) 0.328560647 6.27E-39 1.15659219 p.(E63S) 0.270727573 1.65E-89 2.825487849 p.(E63T) 0.248991576 2.06E-16 1.043567373 p.(E63W) 0.443646248 0 2.766976045 p.(E63Y) 0.418152724 1.65E-40 0.436264141 p.(E63V) 0.250895175 6.52E-11 -0.152868467 p.(G52A) 1.095289643 1.33E-15 -2.011315596 p.(G52R) 0.658528647 0.00037155 -3.799359523 p.(G52N) 0.743467176 9.87E-05 -3.703017369 p.(G52D) 0.81352851 7.44E-66 -1.772558769 p.(G52C) 0.802053338 4.81E-11 -2.744887643 p.(G52Q) 0.906064905 2.88E-99 -1.49289068 p.(G52E) 0.626232084 8.81E-16 -3.550258732 p.(G52G) 0.238663418 0 -0.638262973 p.(G52H) 2.411456799 0 -2.017076453 p.(G52I) 0.772656312 2.69E-18 -3.49451042 p.(G52L) 0.654633554 6.90E-39 -3.843620849 p.(G52K) 0.825620847 9.40E-15 -1.922168273 p.(G52M) 0.443979965 8.31E-79 -2.069795406 p.(G52F) 0.619224855 3.38E-19 -2.715265268 p.(G52P) 0.450931475 1.44E-08 -4.25831709 p.(G52S) 0.14964074 1.82E-06 -1.048911436 p.(G52T) 1.460010078 4.10E-102 -1.384579401 p.(G52W) 0.706192058 2.97E-32 -3.638041559 p.(G52Y) 0.654475861 1.36E-13 -3.589915007 p.(G52V) 0.763623337 7.71E-05 -3.667276806 p.(G62A) 0.738661857 0 2.123831207 p.(G62R) 0.135689304 0.000199382 -0.430703677 p.(G62N) 0.356188027 0.000174889 0.460183866 p.(G62D) 0.483705012 3.50E-12 0.565660648 p.(G62C) 0.244437032 1.76E-11 0.691981759 p.(G62Q) 0.750679829 2.22E-16 1.30341441 p.(G62E) 0.365248656 0 -0.502100652 p.(G62H) 0.472264659 1.29E-09 0.928245083 p.(G62I) 0.474030616 0 1.222097286 p.(G62L) 0.841383523 0 1.426117476 p.(G62K) 0.65831652 4.44E-16 2.137015405 p.(G62M) 0.306009624 3.20E-14 1.358097716 p.(G62F) 0.243246188 4.07E-32 2.574003275 p.(G62P) 0.080001321 6.58E-46 1.557685085 p.(G62S) 0.315471638 8.84E-23 1.067083725 p.(G62T) 0.285205249 1.06E-12 0.678336248 p.(G62W) 0.107751662 3.60E-46 -0.177174696 p.(G62Y) 0.505257336 1.25E-23 0.133158354 p.(G62V) 0.177328306 0 0.082025243 p.(G65A) 0.354888315 2.04E-36 2.203830497 p.(G65R) 0.525052601 7.65E-11 1.375381133 p.(G65N) 0.675144835 2.31E-80 0.349258493 p.(G65D) 0.207675196 4.77E-26 -0.790575752 p.(G65C) 0.341351056 2.78E-08 0.770733651 p.(G65Q) 0.611716895 2.22E-16 0.434903236 p.(G65E) 0.623677828 2.73E-64 -0.719423709 p.(G65G) 0.393394012 0 0.742753002 p.(G65H) 0.524755323 1.17E-52 0.631959022 p.(G65I) 1.129226704 0 4.557982991 p.(G65L) 0.604497218 3.79E-07 1.566407869 p.(G65K) 0.446989374 1.11E-16 1.795144619 p.(G65M) 0.610259561 1.96E-05 2.128779696 p.(G65F) 0.476073224 2.93E-14 3.151247877 p.(G65P) 1.124636815 0 2.101125743 p.(G65S) 0.311659304 1.19E-29 0.707247324 p.(G65T) 0.643932669 1.77E-49 1.164687757 p.(G65W) 1.056634938 4.44E-16 3.984318957 p.(G65Y) 0.229200612 0.001657504 4.145681003 p.(G65V) 1.424488925 0 3.713652103 p.(H53A) 0.677808656 0 1.208834236 p.(H53R) 0.23732354 4.08E-14 -0.280754701 p.(H53N) 0.085356632 5.02E-25 -0.644703916 p.(H53D) 0.447596229 1.91E-08 0.396723396 p.(H53C) 0.428261867 1.49E-12 0.427172235 p.(H53Q) 0.113400865 2.79E-13 -0.744324153 p.(H53E) 0.656865314 1.11E-16 -0.287636924 p.(H53G) 0.233119923 3.68E-54 0.885238935 p.(H53H) 0.15780186 1.39E-17 -0.708778416 p.(H53I) 0.323508515 5.01E-51 0.382004114 p.(H53L) 0.547417221 5.84E-52 0.150194888 p.(H53K) 0.198979833 1.43E-12 -0.273445293 p.(H53M) 0.378332984 4.06E-71 0.232208839 p.(H53F) 0.247986323 2.23E-09 0.351401288 p.(H53P) 0.663661227 1.11E-16 0.825186442 p.(H53S) 0.75023308 5.24E-48 0.34805744 p.(H53T) 0.353615851 3.86E-36 -0.473138216 p.(H53W) 0.409115994 2.30E-10 -0.148367366 p.(H53Y) 0.334046397 1.76E-05 -0.023501529 p.(H53V) 0.358973273 8.50E-29 0.264786562 p.(I59A) 0.7008965 4.44E-16 2.593735828 p.(I59R) 0.504336734 0 1.673226415 p.(I59N) 0.784276168 8.88E-16 3.680384612 p.(I59D) 0.871826189 4.44E-16 2.991643086 p.(I59C) 1.298398948 0 3.416784075 p.(I59Q) 0.998802087 0 3.016242193 p.(I59E) 1.054914843 4.44E-16 2.00276551 p.(I59G) 0.102188399 1.35E-29 0.84298777 p.(I59H) 0.272040278 2.25E-07 1.808345568 p.(I59I) 0.465942282 0 0.548619058 p.(I59L) 0.605742455 2.22E-16 1.638436617 p.(I59K) 0.083389959 2.75E-11 2.314760216 p.(I59M) 0.310420443 5.55E-17 0.548807087 p.(I59F) 0.371920457 1.52E-23 1.74781971 p.(I59P) 0.68446522 0 0.816275099 p.(I59S) 0.501862329 1.91E-87 2.52017721 p.(I59T) 0.588982401 0 2.639233132 p.(I59W) 0.570352759 0 0.832187866 p.(I59Y) 0.337910176 6.14E-14 1.414531211 p.(I59V) 0.205899587 4.40E-45 0.45873426 p.(I72A) 0.151357446 4.74E-12 1.085812614 p.(I72R) 0.561897245 0 4.852783203 p.(I72N) 0.298671148 1.13E-32 1.885301952 p.(I72D) 0.421909835 2.65E-07 1.36329406 p.(I72C) 0.441757356 5.55E-17 1.976234018 p.(I72Q) 0.483311557 5.55E-17 1.491485085 p.(I72E) 0.670198986 4.49E-14 2.645954226 p.(I72G) 0.456062987 5.55E-17 1.699733326 p.(I72H) 0.478427242 5.55E-17 1.284693117 p.(I72I) 0.106740628 4.84E-22 -0.165654169 p.(I72L) 0.367253104 6.26E-05 0.862083691 p.(I72K) 0.83563293 0 4.784281224 p.(I72M) 0.119679404 3.76E-23 0.810116873 p.(I72F) 0.236327409 4.13E-85 0.815334388 p.(I72P) 0.639288662 1.11E-16 1.886674656 p.(I72S) 0.475906421 9.51E-43 2.653661822 p.(I72T) 0.561148526 0 3.018899637 p.(I72W) 0.429069804 7.13E-08 -0.029919551 p.(I72Y) 0.599027307 1.99E-40 0.149049747 p.(I72V) 0.334762115 0 0.647387559 p.(I79A) 0.320702821 1.00E-57 -0.036545931 p.(I79R) 0.453017196 0 0.825612899 p.(I79N) 0.553976267 1.80E-58 0.457657691 p.(I79D) 0.259405131 7.80E-18 1.133559186 p.(I79C) 0.327549482 1.62E-26 0.594679964 p.(I79Q) 0.584124491 1.24E-72 -0.323975792 p.(I79E) 0.716237558 3.21E-52 -0.524004754 p.(I79G) 0.577877598 4.95E-10 -0.156589396 p.(I79H) 0.071868798 5.94E-15 0.003092809 p.(I79L) 0.302615265 1.11E-18 0.61582897 p.(I79K) 0.47300233 1.18E-69 0.455756669 p.(I79M) 0.475666803 3.88E-88 -0.302554109 p.(I79F) 0.445890976 1.78E-88 0.612132229 p.(I79P) 0.261376306 1.47E-53 1.466020138 p.(I79S) 0.273858372 9.79E-37 0.333599207 p.(I79T) 0.111765833 7.95E-31 0.578641263 p.(I79W) 0.748443234 9.02E-164 -0.294565306 p.(I79Y) 0.364545212 1.64E-98 -0.308448143 p.(I79V) 0.387737418 8.96E-39 0.565483514 p.(I87A) 0.691285601 0 2.96503663 p.(I87R) 1.651074833 0 4.818478046 p.(I87N) 1.125376882 0 2.424351115 p.(I87D) 1.41297654 1.78E-15 3.366530579 p.(I87C) 1.393988366 0 2.283616231 p.(I87Q) 0.444874727 5.15E-07 1.397306341 p.(I87E) 0.730978656 0.002586184 2.337981967 p.(I87G) 0.33615713 7.27E-15 2.273337606 p.(I87H) 0.952038401 2.26E-10 3.236719648 p.(I87I) 0.188612681 0.000408217 0.864013453 p.(I87L) 0.629076631 2.22E-16 1.500397536 p.(I87K) 1.505685372 0 5.452392598 p.(I87M) 0.518548287 1.11E-16 1.623245597 p.(I87F) 0.524036569 0 2.601808341 p.(I87P) 1.092764004 0 -2.161118384 p.(I87S) 0.944683917 0 2.188760312 p.(I87T) 0.775166144 0 2.600718399 p.(I87W) 1.192683155 0 3.821601393 p.(I87Y) 0.846967195 0 2.027273504 p.(I87V) 0.538105905 1.11E-16 0.662106191 p.(L69A) 0.285559883 1.53E-86 1.171015922 p.(L69R) 0.311790581 1.33E-55 0.901440467 p.(L69N) 0.557226235 4.89E-08 0.508722948 p.(L69D) 0.44772396 1.14E-11 0.194157725 p.(L69C) 0.101542053 0.000227032 1.756417058 p.(L69Q) 0.450351239 1.84E-85 0.923845798 p.(L69E) 0.363983481 1.02E-47 0.362696881 p.(L69G) 0.322486014 8.33E-17 0.908936069 p.(L69H) 0.389109898 3.50E-06 1.412921293 p.(L69I) 0.736144119 2.06E-52 0.6699902 p.(L69K) 0.180318675 7.38E-09 1.499547275 p.(L69M) 0.435764223 5.55E-17 1.391929983 p.(L69F) 0.514230643 0 1.05953434 p.(L69P) 0.616151699 1.06E-43 0.577102959 p.(L69S) 0.168997925 1.20E-05 0.952032126 p.(L69T) 0.630112528 9.28E-43 0.650397575 p.(L69W) 0.326538698 8.11E-12 0.973240882 p.(L69Y) 0.392499872 1.87E-13 -0.031731729 p.(L69V) 0.424205101 3.60E-26 1.020027156 p.(L85A) 0.945550998 1.20E-105 -0.106929143 p.(L85R) 1.8764049 2.66E-15 -1.118140374 p.(L85N) 0.882293199 6.69E-45 -1.183642804 p.(L85D) 1.113220618 3.26E-42 -1.919612509 p.(L85C) 1.021453804 5.27E-39 -0.097467023 p.(L85Q) 0.545923522 2.87E-50 -1.549852659 p.(L85E) 1.032437557 4.34E-22 -2.411005967 p.(L85G) 0.931584195 1.44E-44 -0.992306613 p.(L85H) 0.791175432 9.97E-26 -0.16031282 p.(L85I) 0.222908323 1.09E-107 1.431641838 p.(L85L) 0.459285245 0 0.83709029 p.(L85K) 0.435662924 2.79E-70 -2.371095012 p.(L85M) 0.798268209 2.09E-120 -0.119544945 p.(L85F) 0.689037373 1.05E-82 0.107850378 p.(L85P) 0.475232865 8.24E-08 1.090342115 p.(L85S) 0.839010382 2.73E-86 -0.898580141 p.(L85T) 0.70670496 4.42E-08 -0.283735503 p.(L85W) 0.357258038 8.70E-70 -0.143743194 p.(L85Y) 0.907043349 2.31E-05 -1.024847837 p.(L85V) 0.567082059 1.11E-16 1.156544218 p.(L90A) 0.645124569 2.15E-83 -0.528807219 p.(L90R) 0.49251729 8.88E-53 -3.096345911 p.(L90N) 0.543330111 2.11E-15 2.827423279 p.(L90D) 0.526274963 1.93E-50 -2.068658252 p.(L90C) 0.454460301 3.43E-107 0.222424608 p.(L90Q) 0.352084631 4.75E-06 0.969617379 p.(L90E) 0.656802217 0 -0.880278889 p.(L90G) 0.476054337 4.00E-69 -0.272185462 p.(L90H) 0.32257885 1.64E-10 1.59843231 p.(L90I) 0.555598619 2.91E-103 -0.043998054 p.(L90L) 0.108948055 3.60E-68 0.205865182 p.(L90K) 0.417039409 5.55E-17 0.123213918 p.(L90M) 0.176942371 7.71E-21 0.553497464 p.(L90F) 0.307369715 1.15E-25 -0.563687884 p.(L90P) 0.88502832 0.007627341 -3.225883706 p.(L90S) 0.810339598 0 0.588895084 p.(L90T) 0.281533152 8.57E-07 0.679464982 p.(L90W) 0.944532866 2.67E-31 -0.225735325 p.(L90Y) 0.709626914 2.22E-15 -1.452957673 p.(L90V) 0.620964506 7.61E-92 -0.417914376 p.(L94A) 0.498035176 0 0.59159349 p.(L94R) 0.935198526 3.77E-06 -2.901178258 p.(L94N) 1.212990198 2.80E-59 -3.008456068 p.(L94D) 0.888436174 1.14E-48 -2.988337425 p.(L94C) 0.849824245 7.84E-73 -0.273656276 p.(L94Q) 0.734361556 2.41E-69 -2.290342264 p.(L94E) 0.530812604 3.29E-11 -3.27872395 p.(L94G) 0.535015864 2.77E-69 -0.53910851 p.(L94H) 1.103233303 5.86E-15 -2.880843943 p.(L94I) 0.427121389 4.55E-12 0.023582112 p.(L94L) 0.076978177 4.14E-67 -0.127243743 p.(L94K) 0.922951133 5.07E-140 -1.990633256 p.(L94M) 0.191066423 4.90E-11 -0.91527785 p.(L94F) 1.112893953 6.50E-63 -0.610896295 p.(L94P) 0.530043176 2.84E-08 -4.408468298 p.(L94S) 0.960354734 0.000914932 -1.797171342 p.(L94T) 0.59963087 3.64E-53 -0.218569861 p.(L94W) 0.680043045 5.76E-44 -1.883619393 p.(L94Y) 0.566690076 6.71E-58 -1.948752062 p.(L94V) 0.312396036 0.000150274 0.917839454 p.(L97A) 0.67552954 4.36E-53 -0.920218556 p.(L97R) 0.70991415 8.84E-21 -3.673241766 p.(L97N) 1.297418771 9.08E-42 -2.142934437 p.(L97D) 1.049859986 0 -3.714793095 p.(L97C) 0.827630124 9.82E-94 -0.576397153 p.(L97Q) 1.304942326 1.21E-47 -2.504449168 p.(L97E) 1.786697534 0 -2.080380313 p.(L97G) 0.919954667 1.44E-64 -1.662011375 p.(L97H) 0.571168548 2.88E-59 -3.57588667 p.(L97I) 0.431754861 4.13E-74 -0.339212491 p.(L97L) 0.225558237 4.47E-15 0.745079814 p.(L97K) 1.259650613 0 -3.176745862 p.(L97M) 0.574763732 2.92E-90 -0.048675472 p.(L97F) 0.45112593 2.92E-49 -1.179206685 p.(L97P) 0.885432289 8.88E-16 -4.938849849 p.(L97S) 1.234087432 5.53E-66 -1.589462606 p.(L97T) 1.134184552 2.16E-25 -0.754034631 p.(L97W) 2.20696738 0 -3.795240826 p.(L97Y) 0.964544593 3.80E-08 -2.847973039 p.(L97V) 0.690562123 3.50E-08 -0.530937078 p.(K49A) 0.506152847 5.96E-84 -0.098808866 p.(K49R) 0.400068537 4.11E-24 0.201760395 p.(K49N) 0.36047873 4.98E-26 0.026583401 p.(K49D) 0.304022906 1.11E-16 0.73441949 p.(K49C) 0.421240053 0.000749184 0.115145194 p.(K49Q) 0.281161221 1.10E-19 0.412687875 p.(K49E) 0.177620565 1.39E-17 -0.642190892 p.(K49G) 0.40737171 3.94E-38 0.256428789 p.(K49H) 0.432956637 1.83E-29 -0.523450495 p.(K49I) 0.9108546 6.65E-18 -0.278392518 p.(K49L) 0.725917516 5.64E-78 -0.559415353 p.(K49K) 0.149501036 1.64E-108 -0.310499231 p.(K49M) 0.524645475 5.68E-56 -0.147904078 p.(K49F) 0.649121392 4.11E-86 -0.832043564 p.(K49P) 0.702259315 6.09E-60 -1.502561694 p.(K49S) 0.71168152 3.88E-128 0.169805655 p.(K49T) 0.556381203 1.89E-24 -0.58046682 p.(K49W) 0.691097462 2.99E-35 -0.988018074 p.(K49Y) 0.773059013 2.29E-30 -0.513959476 p.(K49V) 0.925511713 9.16E-77 -0.546944495 p.(K50A) 1.084250539 4.12E-58 0.042370297 p.(K50R) 0.153125694 1.80E-05 0.730061242 p.(K50N) 0.600796272 6.11E-34 -0.406335944 p.(K50D) 0.607106725 4.81E-126 -1.196771211 p.(K50C) 1.171747483 1.26E-81 -2.178042775 p.(K50Q) 0.362029657 1.94E-16 2.031959892 p.(K50E) 0.280399215 4.09E-51 0.041187866 p.(K50G) 0.51043897 1.39E-50 -0.004316759 p.(K50H) 0.620419734 1.22E-21 -0.173359491 p.(K50I) 1.303296531 2.14E-06 -3.553581504 p.(K50L) 1.157175515 4.85E-70 -2.082637718 p.(K50M) 0.433404619 7.11E-53 -1.978812104 p.(K50F) 0.858875145 5.16E-06 -3.095161289 p.(K50P) 0.282674586 6.02E-59 0.281646435 p.(K50S) 0.544831199 6.31E-69 -0.140369233 p.(K50T) 1.069061704 5.14E-37 -1.670074572 p.(K50W) 0.350719373 1.10E-14 -4.009146751 p.(K50Y) 0.927007288 4.04E-41 -2.08365327 p.(K50V) 0.818041245 3.77E-81 -1.712663203 p.(K64A) 0.295412602 4.43E-12 1.404362966 p.(K64R) 0.231388915 7.92E-22 0.609997429 p.(K64N) 0.463356564 3.34E-37 0.202606432 p.(K64D) 0.735347701 2.13E-47 -0.316338791 p.(K64C) 0.364579062 1.39E-31 1.378217699 p.(K64Q) 0.785700909 2.03E-45 0.052182851 p.(K64E) 0.247322721 5.62E-51 -0.541180523 p.(K64G) 0.355744624 0 0.628444272 p.(K64H) 0.401343644 8.69E-10 0.152787603 p.(K64I) 0.152786852 1.88E-30 0.761266782 p.(K64L) 0.638674249 0 1.296305056 p.(K64M) 0.483306636 0 -0.966774918 p.(K64F) 0.368187402 3.04E-37 0.264422093 p.(K64P) 0.566075706 2.29E-53 -0.383628903 p.(K64S) 0.58038404 3.62E-34 0.394570577 p.(K64T) 0.85969271 0 0.899423389 p.(K64W) 0.382872235 0 -0.683948872 p.(K64Y) 0.787761124 1.87E-47 -0.363073614 p.(K64V) 0.593793004 6.66E-16 1.473390921 p.(M84A) 0.421001206 1.10E-09 0.010344118 p.(M84R) 0.495779453 1.11E-66 1.038800891 p.(M84N) 0.979540048 1.58E-178 -0.226773424 p.(M84D) 1.076269518 4.18E-31 -0.205153184 p.(M84C) 0.651318081 4.70E-40 -0.280138456 p.(M84Q) 1.192564369 3.77E-56 -0.18877807 p.(M84E) 0.972388988 7.63E-40 -0.387059404 p.(M84G) 0.573021146 2.69E-34 -0.298306845 p.(M84H) 0.16576471 6.33E-11 0.729442209 p.(M84I) 0.200725356 3.33E-48 0.046364134 p.(M84L) 0.467438483 4.35E-14 0.449513015 p.(M84K) 0.136318991 7.51E-20 1.595682815 p.(M84F) 0.352441539 2.78E-17 1.042998667 p.(M84P) 0.375946124 1.66E-46 1.206007558 p.(M84S) 0.841337762 8.86E-80 -0.928189095 p.(M84T) 0.836489339 4.26E-24 -0.531130846 p.(M84W) 0.827530735 0 3.353162826 p.(M84Y) 0.495320296 1.67E-16 2.220375718 p.(M84V) 0.440430565 3.30E-06 0.070172682 p.(F58A) 0.657463081 2.22E-16 1.349516307 p.(F58R) 1.023247478 0 2.214046895 p.(F58N) 0.99717152 0 2.777965117 p.(F58D) 0.270993938 1.65E-13 2.122629958 p.(F58C) 0.664534037 2.22E-16 1.867208325 p.(F58Q) 0.374599653 1.47E-07 1.767989386 p.(F58E) 0.511864774 0 0.753729639 p.(F58G) 0.092819479 6.86E-22 0.987774796 p.(F58H) 0.167011365 0.000429337 0.829851551 p.(F58I) 0.500263492 1.93E-11 0.400070455 p.(F58L) 0.704853405 2.22E-16 1.430257115 p.(F58K) 0.363898003 0.001862165 2.237908112 p.(F58M) 0.667441531 2.22E-16 2.102768746 p.(F58F) 0.040390067 9.83E-78 -0.609242369 p.(F58P) 0.422946183 0.002140341 0.952288434 p.(F58S) 0.469644484 7.70E-19 1.482156387 p.(F58T) 0.783897633 6.66E-16 2.048863867 p.(F58W) 0.56623946 4.65E-52 0.375419162 p.(F58Y) 0.437005833 6.47E-43 1.177261533 p.(F58V) 0.29905792 3.80E-05 0.55235811 p.(F73A) 0.688807741 0 1.645279784 p.(F73R) 0.597716766 0 3.01968882 p.(F73N) 0.397790255 5.55E-17 1.611759401 p.(F73D) 0.306877773 4.05E-15 2.224563835 p.(F73C) 0.563108135 0 1.43620036 p.(F73Q) 0.713237482 0 2.437157541 p.(F73E) 0.669170051 0 1.89113511 p.(F73G) 0.360444322 6.90E-40 1.799924853 p.(F73H) 0.707324162 2.22E-16 2.088434445 p.(F73I) 0.338823159 4.03E-32 0.213936611 p.(F73L) 0.055189122 1.13E-29 -0.06171104 p.(F73K) 0.487807432 1.69E-12 2.317664669 p.(F73M) 0.582532459 3.25E-10 0.921575194 p.(F73P) 0.78280076 0 3.930969193 p.(F73S) 0.380873543 1.45E-12 2.744164373 p.(F73T) 0.419397333 2.03E-11 1.176094913 p.(F73W) 0.242502001 1.64E-31 0.544574844 p.(F73Y) 0.501765877 5.42E-85 0.564559646 p.(F73V) 0.547768382 2.02E-09 1.954325227 p.(F88A) 0.26682199 6.56E-93 0.388403115 p.(F88R) 0.953278256 1.79E-10 -2.301214182 p.(F88N) 0.482536483 5.24E-92 0.041905142 p.(F88D) 0.433962869 2.68E-55 0.914686165 p.(F88C) 0.381419726 0.000287825 0.829075984 p.(F88Q) 0.727706439 2.36E-72 -0.05739005 p.(F88E) 0.819629141 1.60E-105 -0.550383775 p.(F88G) 0.432129041 6.84E-54 1.296888996 p.(F88H) 0.79555742 4.34E-22 0.207295891 p.(F88I) 0.378816463 0 1.411306811 p.(F88L) 0.207433655 0.000281 0.06976261 p.(F88K) 1.718965746 0 -3.47933221 p.(F88M) 0.463731046 1.91E-11 1.301431275 p.(F88F) 0.097717083 1.85E-90 -0.082812203 p.(F88P) 1.005660781 2.52E-34 -0.624164415 p.(F88S) 0.14226229 3.11E-102 -0.033189537 p.(F88T) 0.487988701 1.30E-06 0.628402488 p.(F88W) 1.119460987 3.63E-74 0.040892596 p.(F88Y) 0.623949256 7.46E-41 0.351573247 p.(F88V) 0.338367279 0.000167202 1.180843302 p.(F92A) 0.31467093 2.09E-10 1.055442317 p.(F92R) 0.984210492 1.04E-40 0.056037978 p.(F92N) 1.032437534 1.88E-66 -0.104185441 p.(F92D) 0.964979495 2.34E-76 -0.832508513 p.(F92C) 0.322199669 5.03E-13 1.816983029 p.(F92Q) 0.776128253 1.55E-109 -0.00080972 p.(F92E) 0.665025074 5.70E-35 -1.546275505 p.(F92G) 0.260499171 1.90E-11 -0.399760225 p.(F92H) 1.182674303 1.83E-23 -0.152576378 p.(F92I) 0.464291524 1.11E-16 2.456724504 p.(F92L) 0.298038016 3.47E-11 1.51406711 p.(F92K) 0.860812943 4.19E-35 0.461776882 p.(F92M) 0.439913553 4.13E-11 0.945440397 p.(F92P) 0.478965604 1.78E-107 0.46062968 p.(F92S) 0.467852252 7.12E-36 0.309260065 p.(F92T) 0.557496151 6.91E-13 0.876379084 p.(F92W) 0.589713243 0 0.686880181 p.(F92Y) 1.069095411 6.01E-20 -0.438741087 p.(F92V) 0.384892645 1.67E-46 1.997654512 p.(F98A) 0.642363558 4.44E-16 1.687323233 p.(F98R) 0.636446398 3.47E-14 -3.829069267 p.(F98N) 1.696039724 0 -2.150111981 p.(F98D) 0.811572733 1.26E-67 -3.422758165 p.(F98C) 0.524807525 0 1.940440619 p.(F98Q) 1.510204529 5.24E-14 -2.16356615 p.(F98E) 0.636248317 3.63E-35 -3.838986887 p.(F98G) 0.91479152 3.65E-61 -0.53383531 p.(F98H) 0.648506081 0.004279468 -4.114464489 p.(F98I) 0.483653186 0 2.533142354 p.(F98L) 0.325680851 4.43E-18 1.462834674 p.(F98K) 1.361723984 8.88E-16 -3.720570429 p.(F98M) 0.592976653 0 1.97058248 p.(F98F) 0.097430909 2.89E-21 -0.868648603 p.(F98P) 1.134860362 3.04E-06 -2.429413993 p.(F98S) 0.353078469 0 -0.618357128 p.(F98T) 0.128360762 1.47E-57 1.035919878 p.(F98W) 0.389009201 4.52E-96 -2.823324647 p.(F98Y) 0.785611118 1.05E-43 -2.874108948 p.(F98V) 0.420451584 1.11E-16 1.887287869 p.(S95A) 0.916138654 4.44E-16 2.766616904 p.(S95R) 0.86864158 6.27E-21 -0.606160206 p.(S95N) 0.767787379 7.51E-08 0.07863468 p.(S95D) 0.41467576 5.87E-70 -2.349499454 p.(S95C) 0.470697355 7.07E-21 2.297303245 p.(S95Q) 0.465070599 2.12E-39 0.468894401 p.(S95E) 0.903720758 1.48E-41 -1.831866086 p.(S95G) 0.526780931 8.50E-67 0.530148559 p.(S95H) 0.678392691 3.74E-48 -1.907985894 p.(S95I) 0.470971397 0.000153277 1.888871177 p.(S95L) 0.365260727 0.001172107 2.143410549 p.(S95K) 1.187155766 5.95E-08 -1.971610357 p.(S95M) 0.842107186 0 3.268202719 p.(S95F) 0.494620504 3.62E-31 -0.087185663 p.(S95P) 0.664576 2.10E-59 -0.864468564 p.(S95S) 0.249057125 4.36E-13 1.040463714 p.(S95T) 0.550070673 6.19E-70 2.782239492 p.(S95W) 0.892100218 0.003272096 -0.550235706 p.(S95Y) 0.241351713 4.14E-42 -1.927880549 p.(S95V) 0.578019397 2.37E-18 2.19684341 p.(T74A) 0.316521296 0 1.555007504 p.(T74R) 0.440977831 1.11E-16 0.63235251 p.(T74N) 0.328826128 2.82E-33 1.150368913 p.(T74D) 0.782973839 0 0.376922745 p.(T74C) 0.600354345 2.22E-16 1.166075259 p.(T74Q) 0.453443356 1.11E-16 1.140617551 p.(T74E) 0.457344867 1.38E-54 1.948955466 p.(T74G) 0.445878343 3.55E-08 1.58567918 p.(T74H) 0.267151609 0 1.108288368 p.(T74I) 0.890724077 3.61E-99 -0.064967787 p.(T74L) 0.57427686 1.83E-51 0.065022679 p.(T74K) 0.323455282 1.37E-14 0.067344825 p.(T74M) 0.500139321 1.24E-65 -0.254412554 p.(T74F) 0.921756029 1.02E-71 -0.55538005 p.(T74P) 0.082739142 2.99E-16 3.024329325 p.(T74S) 0.30788999 1.71E-10 1.092459659 p.(T74T) 0.117036104 1.60E-15 0.608782514 p.(T74W) 0.543759723 0.001048068 -0.897059406 p.(T74Y) 0.531382211 2.29E-25 0.577222296 p.(T74V) 0.586072739 1.17E-24 0.090310327 p.(T75A) 0.28365774 1.22E-41 0.442403451 p.(T75R) 0.419148576 2.93E-14 1.165778066 p.(T75N) 0.198057097 1.09E-13 -0.178261032 p.(T75D) 0.609209143 2.99E-32 0.091405204 p.(T75C) 0.092622402 6.98E-12 -0.479625057 p.(T75Q) 0.929149745 0 0.20388461 p.(T75E) 0.42401169 8.73E-103 0.001770281 p.(T75G) 0.845534314 9.57E-73 0.10946502 p.(T75H) 0.47799009 5.75E-62 0.114352384 p.(T75I) 0.997985482 2.28E-185 -0.030227128 p.(T75L) 0.257053733 3.57E-46 -0.481179328 p.(T75K) 0.583639568 2.22E-16 1.867587872 p.(T75M) 0.459664988 4.15E-59 0.113380149 p.(T75F) 0.618851031 5.68E-14 1.346218176 p.(T75P) 0.630276033 0 3.172043657 p.(T75S) 0.501317737 0 0.872025263 p.(T75T) 0.210498263 3.36E-24 -0.144562279 p.(T75W) 0.593673992 2.65E-15 0.206322605 p.(T75Y) 0.377310005 4.95E-39 -0.396081733 p.(T75V) 0.860162978 4.66E-109 -0.262739159 p.(W81A) 1.278839311 3.80E-94 0.245749142 p.(W81R) 1.137855125 9.98E-47 -0.366817581 p.(W81N) 0.611042655 4.25E-11 -1.576502848 p.(W81D) 0.825873381 3.93E-50 -1.410895062 p.(W81C) 0.616223114 1.20E-52 -1.019191491 p.(W81Q) 1.584415238 0 -1.423383709 p.(W81E) 1.39649049 0 -1.393671792 p.(W81G) 0.749321717 9.85E-102 -0.450943345 p.(W81H) 1.274378891 1.78E-15 -0.22928531 p.(W81I) 0.515239602 4.87E-12 1.34151958 p.(W81L) 0.368385414 5.11E-54 0.985245794 p.(W81K) 1.125407171 7.41E-58 0.164647318 p.(W81M) 0.724381239 2.77E-29 0.023631108 p.(W81F) 0.407109444 9.92E-15 1.086328403 p.(W81P) 0.684304457 9.80E-34 -2.429355027 p.(W81S) 0.879276659 0.000832703 -1.522724633 p.(W81T) 0.509525122 5.56E-93 -0.3284898 p.(W81Y) 0.978822876 1.47E-90 -0.00478909 p.(W81V) 1.098082746 5.36E-61 -0.299114907 p.(W83A) 0.517207051 3.98E-11 -1.214006667 p.(W83R) 0.445277854 0 0.247419955 p.(W83N) 0.515178165 1.11E-16 1.532016114 p.(W83D) 0.84257103 1.30E-21 -0.952160705 p.(W83C) 0.367434533 5.98E-08 -0.965385583 p.(W83Q) 0.526342693 7.53E-15 -0.167300915 p.(W83E) 0.647234474 2.19E-40 -0.794067514 p.(W83G) 0.627491602 7.40E-08 -0.197252981 p.(W83H) 0.258600316 3.62E-162 0.282166896 p.(W83I) 1.020398543 0 -3.230444863 p.(W83L) 1.033089888 1.11E-33 -0.187723604 p.(W83K) 0.28036773 0 0.839785396 p.(W83M) 0.915122716 1.45E-21 -0.143099303 p.(W83F) 0.989567472 4.85E-14 -0.44054525 p.(W83P) 0.657975616 3.43E-41 -0.085413311 p.(W83S) 0.397790227 0 0.681341633 p.(W83T) 0.540188116 1.11E-16 0.37754439 p.(W83Y) 0.497735494 4.09E-22 1.862939648 p.(W83V) 0.899171866 2.57E-13 -1.375442032 p.(W96A) 0.573328147 5.03E-13 0.429394747 p.(W96R) 0.812739898 9.77E-05 -4.302397754 p.(W96N) 0.647906294 3.74E-11 -1.369437402 p.(W96D) 0.397140311 9.21E-32 -4.111737884 p.(W96C) 0.345540108 9.20E-16 0.955146397 p.(W96Q) 0.678793359 1.30E-24 -2.579450545 p.(W96E) 1.548346305 3.69E-17 -1.926617746 p.(W96G) 0.584284338 6.45E-18 0.147790932 p.(W96H) 0.778209263 1.03E-151 -2.43197959 p.(W96I) 0.832317115 6.66E-16 1.637000087 p.(W96L) 0.379790187 0 2.102162966 p.(W96K) 0.557858814 4.06E-05 -3.697538502 p.(W96M) 0.427534514 1.66E-08 0.700900344 p.(W96F) 0.90447467 1.05E-58 -0.4862687 p.(W96P) 1.229811764 2.71E-31 -1.787894433 p.(W96S) 0.461634256 5.24E-18 -0.304233259 p.(W96T) 0.379026777 4.00E-27 0.215733483 p.(W96Y) 0.818383014 3.56E-78 -1.516957349 p.(W96V) 0.52582816 3.17E-54 2.579505807 p.(Y68A) 0.442239365 3.54E-07 0.335500974 p.(Y68R) 0.339000791 7.59E-21 0.36584706 p.(Y68N) 0.523629894 1.97E-16 0.764408622 p.(Y68D) 0.152882108 1.43E-67 -0.382139956 p.(Y68C) 0.549926576 7.70E-13 1.939925816 p.(Y68Q) 0.584001715 1.11E-16 0.890919688 p.(Y68E) 0.423208929 6.10E-37 0.763078426 p.(Y68G) 0.464204011 2.46E-60 0.323356801 p.(Y68H) 0.355092877 0.001264227 0.468669768 p.(Y68I) 0.641317363 0 1.748174945 p.(Y68L) 0.368487777 7.81E-33 0.696173507 p.(Y68K) 0.481693737 0.000314169 0.894619587 p.(Y68M) 0.47305603 1.09E-64 0.84324713 p.(Y68F) 0.574202398 1.11E-16 1.796101209 p.(Y68P) 0.263809435 5.87E-10 0.453937186 p.(Y68S) 0.300704586 1.75E-15 1.586605502 p.(Y68T) 0.386995387 7.44E-14 0.548857075 p.(Y68W) 0.38323029 2.26E-13 1.51306855 p.(Y68Y) 0.186428513 1.39E-17 -0.239659033 p.(Y68V) 0.268846087 3.15E-11 0.69354457 p.(V56A) 0.609319203 2.22E-16 1.439120633 p.(V56R) 0.598765113 1.01E-25 -0.137377129 p.(V56N) 0.307413683 2.27E-12 0.217113939 p.(V56D) 0.690724775 1.51E-11 -1.22910485 p.(V56C) 0.126832307 4.30E-28 1.385523783 p.(V56Q) 0.2997193 9.20E-49 0.472846869 p.(V56E) 0.638158546 3.30E-53 -0.165894804 p.(V56G) 0.541605228 4.03E-40 -0.220704874 p.(V56H) 0.36703312 2.72E-28 0.592962854 p.(V56I) 0.318528991 4.01E-79 0.290768287 p.(V56L) 0.289762854 0 1.158475509 p.(V56K) 0.813548754 2.20E-07 -1.195707467 p.(V56M) 0.157841985 0 0.471011007 p.(V56F) 0.203579573 1.95E-60 1.578379859 p.(V56P) 0.551890613 1.14E-38 -1.505667085 p.(V56S) 0.388815106 5.55E-17 1.505958541 p.(V56T) 0.999000838 1.33E-15 2.358093494 p.(V56W) 0.645105888 2.09E-31 0.736183251 p.(V56Y) 0.555948765 1.50E-104 -0.240062847 p.(V56V) 0.123445376 6.94E-18 0.124436622 p.(V61A) 0.248545047 9.59E-08 0.233920393 p.(V61R) 0.919148083 4.44E-16 1.798778691 p.(V61N) 0.326081917 3.21E-07 2.204919717 p.(V61D) 0.717304351 0 2.494750953 p.(V61C) 0.535180144 2.22E-16 2.017888872 p.(V61Q) 0.624929323 2.22E-16 1.718675361 p.(V61E) 0.764923227 4.44E-16 1.730048771 p.(V61G) 0.641033005 0 3.073393062 p.(V61H) 0.359367657 1.37E-09 0.735700805 p.(V61I) 0.483906721 2.90E-87 0.668868422 p.(V61L) 0.255724011 0.000157069 0.424271212 p.(V61K) 0.592239836 0 1.959575264 p.(V61M) 0.074825066 7.17E-09 -0.451011999 p.(V61F) 0.459932094 6.99E-27 0.097599513 p.(V61P) 0.162162386 1.05E-16 1.546458093 p.(V61S) 0.537088778 0 1.84160942 p.(V61T) 0.42572314 7.42E-68 0.594393978 p.(V61W) 0.688155186 0 0.239790566 p.(V61Y) 0.383257465 0 0.666560278 p.(V61V) 0.037581139 2.28E-08 -0.02345347 p.(V77A) 0.376924343 4.57E-13 0.862231636 p.(V77R) 0.456722212 3.88E-10 0.388629012 p.(V77N) 0.379180888 1.75E-23 0.054034509 p.(V77D) 0.206033625 1.66E-54 0.885277616 p.(V77C) 0.502248959 1.29E-48 1.230275624 p.(V77Q) 0.545246089 1.97E-84 -0.194102594 p.(V77E) 0.620904018 1.00E-55 0.009795287 p.(V77G) 0.51323909 1.64E-14 1.887108551 p.(V77H) 0.444011541 3.64E-08 0.262274358 p.(V77I) 0.61075899 0 1.266497586 p.(V77L) 0.461493976 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2.06E-10 -0.96831892 p.(A129Q) 0.631573734 1.65E-13 0.193212605 p.(A129E) 1.0099984 1.45E-114 -0.509456068 p.(A129G) 0.830075701 2.96E-27 0.366625081 p.(A129H) 0.419494662 4.94E-53 -1.174801559 p.(A129I) 0.594969594 4.60E-243 -0.65277785 p.(A129L) 0.063279914 1.30E-10 1.295311705 p.(A129K) 1.460669378 1.78E-52 0.144348494 p.(A129M) 0.512209417 2.22E-16 2.288345639 p.(A129F) 0.473735092 5.55E-17 1.066544251 p.(A129P) 0.6994933 8.29E-62 -0.321411496 p.(A129S) 0.480316279 2.29E-23 0.550908213 p.(A129T) 0.559215685 1.83E-32 -0.284406377 p.(A129W) 0.59958273 5.42E-32 -0.426979807 p.(A129Y) 0.763665499 1.91E-48 -0.417522337 p.(A129V) 0.166606021 1.66E-22 -0.617080981 p.(A139A) 0.378090369 1.42E-32 0.370875445 p.(A139R) 1.384537162 2.72E-08 -3.95053224 p.(A139N) 0.630704608 0 2.934810919 p.(A139D) 0.532894287 3.87E-13 2.323696835 p.(A139C) 2.581744387 1.78E-15 -5.420699755 p.(A139Q) 0.316592608 1.37E-36 0.089785093 p.(A139E) 0.165136955 1.01E-21 0.110868936 p.(A139G) 0.742264517 0 3.285274775 p.(A139H) 0.439138347 1.77E-62 -0.307559368 p.(A139I) 0.648477914 5.53E-39 -3.978928802 p.(A139L) 1.508809003 2.35E-74 -1.809821976 p.(A139K) 1.032269422 2.83E-15 -1.226582727 p.(A139M) 0.942315345 8.98E-46 -0.714612349 p.(A139F) 0.771101769 2.74E-54 -2.347658625 p.(A139P) 1.025314203 4.74E-54 -1.114029539 p.(A139S) 0.471715327 2.81E-13 2.376741547 p.(A139T) 0.556111984 1.11E-16 1.013557926 p.(A139W) 0.652148462 0.001979881 -4.015711609 p.(A139Y) 2.878990291 7.11E-15 -5.154855757 p.(A139V) 0.69807305 2.30E-60 -3.573334415 p.(A140R) 0.677316328 0.002942017 -3.81458924 p.(A140N) 1.042996452 0.000291798 -2.484967776 p.(A140D) 0.175761775 1.19E-45 -2.991181086 p.(A140C) 1.067844284 2.84E-63 -0.440129584 p.(A140Q) 0.954507699 1.16E-10 -1.378085256 p.(A140E) 0.591432492 3.29E-44 -4.361468967 p.(A140G) 0.944006539 8.13E-13 -1.271739926 p.(A140H) 0.763921249 2.34E-55 -3.354410217 p.(A140I) 1.113594935 9.77E-15 -4.121502869 p.(A140L) 0.715708395 0.005125603 -1.73791752 p.(A140K) 0.466139001 8.81E-12 -4.36692484 p.(A140M) 1.435429529 1.64E-40 -1.013631877 p.(A140F) 1.526743378 0 -0.754142218 p.(A140P) 0.518918006 3.35E-41 -3.389020797 p.(A140S) 0.113749618 1.93E-119 1.035039583 p.(A140T) 1.073277241 2.69E-20 -2.713191949 p.(A140W) 0.467233675 5.31E-14 -3.999271441 p.(A140Y) 0.990033392 1.47E-17 -2.254864171 p.(A140V) 0.98336278 2.82E-69 -2.326106697 p.(N135A) 0.325794881 0.000649228 0.99011679 p.(N135R) 0.380970708 1.62E-15 0.072183737 p.(N135D) 0.236488738 3.56E-102 0.512670627 p.(N135C) 0.950189416 1.37E-66 -0.422054416 p.(N135Q) 1.011894135 0 1.627569821 p.(N135E) 0.613285136 1.34E-36 0.74312455 p.(N135G) 0.453659915 6.69E-14 1.254138591 p.(N135H) 0.681657812 0 2.23887231 p.(N135I) 0.147326388 7.58E-63 -0.689848605 p.(N135L) 0.744899901 1.37E-46 -0.479708647 p.(N135K) 0.260833259 2.05E-40 0.268134525 p.(N135M) 0.490698798 1.93E-20 0.374427676 p.(N135F) 0.48984892 1.84E-85 0.259863416 p.(N135P) 1.240163762 4.98E-35 -1.966532117 p.(N135S) 0.310837426 0.001261059 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4.11E-06 2.472984047 p.(D121S) 0.604827812 2.22E-16 1.958827134 p.(D121T) 0.700271958 0 0.554040496 p.(D121W) 0.522906511 8.27E-12 1.813292098 p.(D121Y) 0.743763363 0 1.77488301 p.(D121V) 0.514546377 0 0.442566757 p.(D122A) 1.093871933 1.25E-08 -2.26405608 p.(D122R) 0.663607091 1.45E-50 -3.801411152 p.(D122N) 0.430337158 8.13E-27 -1.173533808 p.(D122D) 0.155547567 1.20E-15 -0.201894034 p.(D122C) 0.757261672 8.20E-27 -3.977074 p.(D122Q) 0.741380057 1.65E-49 -2.836784298 p.(D122E) 0.489512643 1.58E-123 -0.605792173 p.(D122G) 0.644464227 2.85E-42 -4.041236527 p.(D122H) 0.734522892 2.70E-07 -3.903978693 p.(D122I) 1.332805758 7.75E-11 -2.770035953 p.(D122L) 0.402484489 1.35E-39 -1.679767134 p.(D122K) 0.382399926 4.05E-16 -4.563199785 p.(D122M) 0.649161528 1.13E-07 -2.298833079 p.(D122F) 0.528319861 6.90E-76 -1.165412362 p.(D122P) 0.747266172 1.31E-08 -3.686859026 p.(D122S) 0.412419252 1.02E-26 -2.403890462 p.(D122T) 0.824682216 1.57E-11 -3.312023424 p.(D122W) 0.484647445 2.75E-66 -2.863012674 p.(D122Y) 0.411193321 3.49E-27 -2.02127628 p.(D122V) 0.717786305 1.31E-12 -1.258808186 p.(C101A) 0.45501552 9.58E-54 0.520074272 p.(C101R) 0.903141074 1.09E-12 -3.237255631 p.(C101N) 0.352814021 5.13E-110 -0.06678552 p.(C101D) 0.535419986 2.39E-55 -4.311911539 p.(C101Q) 0.883506667 0.000111053 -1.863733374 p.(C101E) 0.598754579 3.03E-52 -0.879730275 p.(C101G) 0.397559367 8.05E-15 3.816320341 p.(C101H) 1.027935617 1.25E-29 -0.192531084 p.(C101I) 0.654752304 1.24E-37 -0.921245642 p.(C101L) 0.36922473 2.75E-07 3.500650966 p.(C101K) 1.242581513 6.66E-15 -1.68845482 p.(C101M) 0.836829692 0 1.509791466 p.(C101F) 0.264384103 3.13E-24 -0.01354574 p.(C101P) 0.670078501 1.51E-72 -4.062614101 p.(C101S) 0.28846902 7.87E-08 0.264437334 p.(C101T) 0.549723317 3.07E-10 0.498334574 p.(C101W) 0.36015645 2.60E-33 -0.923710887 p.(C101Y) 0.765647168 4.99E-59 -1.180580605 p.(C101V) 0.479978498 9.31E-25 0.48732097 p.(C130A) 0.956350818 1.02E-07 -2.294967259 p.(C130R) 0.347977693 1.11E-16 -1.049331594 p.(C130N) 1.152415784 3.66E-08 -1.258319971 p.(C130D) 1.515408127 3.02E-22 -2.556244828 p.(C130C) 0.112798596 2.51E-12 -0.855921203 p.(C130Q) 0.347977693 1.11E-16 -1.049331594 p.(C130E) 0.171089839 5.12E-20 -1.486293401 p.(C130G) 0.478745665 0 -0.92204175 p.(C130H) 1.081061015 1.56E-40 -2.561132445 p.(C130I) 1.325301988 5.19E-54 -1.301867869 p.(C130L) 1.643100351 8.45E-66 -1.220841682 p.(C130K) 1.055574535 0.020089734 -1.694538197 p.(C130M) 0.347977693 1.11E-16 -1.049331594 p.(C130F) 1.466942278 2.03E-31 0.002321091 p.(C130P) 0.994406366 0.010668116 -3.007647258 p.(C130S) 2.496770199 3.99E-34 -1.901646738 p.(C130T) 2.751369406 1.38E-83 -4.453995692 p.(C130W) 1.53095234 0 0.506380438 p.(C130Y) 0.420879357 1.22E-34 -1.964117802 p.(C130V) 1.209103669 5.90E-07 -2.957402973 p.(E133A) 0.971052445 2.89E-42 -0.333032428 p.(E133R) 0.550090268 3.08E-49 -0.901438126 p.(E133N) 0.20957199 4.89E-41 1.421511911 p.(E133D) 0.485000065 4.64E-67 0.001190929 p.(E133C) 0.769233616 7.34E-67 -0.306634242 p.(E133Q) 0.363165907 3.53E-08 1.509112887 p.(E133E) 0.106122796 0 0.015636055 p.(E133G) 0.502650168 0 0.547658752 p.(E133H) 0.598129156 1.22E-71 0.330384029 p.(E133I) 1.444490179 4.47E-25 -1.042015938 p.(E133L) 1.655670233 2.03E-06 -0.762898878 p.(E133K) 0.899878503 1.84E-76 -0.483259479 p.(E133M) 0.295880111 1.24E-66 1.105193204 p.(E133F) 0.859871327 2.96E-06 -0.79022261 p.(E133P) 1.710223331 0 -1.283466432 p.(E133S) 0.365614498 9.33E-08 0.453201371 p.(E133T) 1.028238754 3.76E-34 -0.499394317 p.(E133W) 1.868774576 2.92E-47 -1.867474677 p.(E133Y) 0.969946826 3.52E-25 0.096006768 p.(E133V) 0.977070475 1.27E-49 -2.253941963 p.(E146A) 0.883228482 7.65E-47 -0.490531319 p.(E146R) 0.853848176 4.92E-80 -0.48786766 p.(E146N) 0.470901353 1.23E-77 -2.159196862 p.(E146D) 1.320715841 2.33E-50 -1.802517528 p.(E146C) 0.994183907 7.05E-52 -1.945075965 p.(E146Q) 1.620677242 1.78E-15 -0.170608317 p.(E146E) 0.222727742 0 0.467791782 p.(E146G) 0.621542592 2.58E-45 -0.153094137 p.(E146H) 0.806783825 3.60E-32 -1.322941952 p.(E146I) 0.594706143 7.96E-61 -1.901744991 p.(E146L) 0.617950576 3.85E-69 -2.009348279 p.(E146K) 0.636649165 8.45E-52 -1.24865088 p.(E146M) 1.319506245 2.01E-51 -0.714166819 p.(E146F) 1.347267157 2.08E-50 -1.79861063 p.(E146P) 1.644939466 6.13E-186 -1.624031047 p.(E146S) 0.714905719 1.18E-28 -1.050368941 p.(E146T) 1.362933381 0 -1.403343885 p.(E146W) 0.726825256 5.50E-145 -1.998558663 p.(E146Y) 0.89880467 2.02E-10 -2.442144426 p.(E146V) 1.291140742 1.33E-15 -3.236484384 p.(G100A) 0.236879427 0 0.445051799 p.(G100R) 1.487030194 0 -4.329939303 p.(G100N) 0.711843149 0.003885862 -3.772839461 p.(G100D) 0.5332444 4.38E-20 -3.065927566 p.(G100C) 0.322159984 8.13E-22 -1.557218082 p.(G100Q) 0.7806658 1.73E-49 -3.509505772 p.(G100E) 1.37151427 1.33E-15 -2.940744635 p.(G100G) 0.176990879 1.39E-17 -0.555632415 p.(G100H) 1.470577266 1.78E-15 -3.050845823 p.(G100I) 0.902942871 1.44E-30 -3.000727306 p.(G100L) 0.688264363 4.78E-06 -3.264134937 p.(G100K) 0.673149229 4.83E-26 -3.223064471 p.(G100M) 0.633603375 4.89E-08 -3.624306853 p.(G100F) 0.755174828 5.78E-21 -3.610952808 p.(G100P) 0.245021243 1.80E-37 -4.94934685 p.(G100S) 0.798541546 7.19E-44 -0.547411612 p.(G100T) 1.228122173 2.86E-09 -2.621406383 p.(G100W) 0.643972817 5.39E-15 -3.600023786 p.(G100Y) 1.020336858 2.22E-16 -3.469326881 p.(G100V) 0.971064646 0 -3.981514693 p.(G111A) 0.634505875 2.90E-79 -1.245706972 p.(G111R) 0.700967793 3.14E-28 -0.62301701 p.(G111N) 1.005623871 1.28E-07 1.02946416 p.(G111D) 1.052609189 4.25E-56 0.038692056 p.(G111C) 0.874140289 1.64E-61 -2.136675823 p.(G111Q) 0.88909731 7.66E-47 -0.756551774 p.(G111E) 0.667239512 1.44E-08 -0.463955667 p.(G111G) 0.45760082 0 0.84204782 p.(G111H) 0.812338309 5.46E-24 -0.351448691 p.(G111I) 0.710897236 6.88E-15 -4.161337381 p.(G111L) 1.245053587 3.66E-09 -1.400737448 p.(G111K) 0.859163156 5.63E-05 -0.966040404 p.(G111M) 1.385690094 3.78E-48 -2.150684136 p.(G111F) 0.93968996 0.003506131 -1.978540545 p.(G111P) 0.767436606 5.09E-46 -3.212628554 p.(G111S) 0.869552184 1.86E-30 -0.055476813 p.(G111T) 1.865360275 5.39E-72 -0.20190145 p.(G111W) 1.231729195 1.76E-13 -1.605953422 p.(G111Y) 1.008542937 4.55E-52 -2.353689787 p.(G111V) 0.817000109 1.46E-06 -1.931475574 p.(H110A) 1.51708865 4.00E-15 -0.960997168 p.(H110R) 0.96017129 5.74E-06 -2.794134836 p.(H110N) 0.27570157 1.03E-54 -0.531224105 p.(H110D) 1.585064299 6.28E-35 -1.712437808 p.(H110C) 0.392782285 3.04E-25 -4.43321983 p.(H110Q) 0.98150526 5.20E-16 -2.468895402 p.(H110E) 1.213198496 3.37E-53 0.791472986 p.(H110G) 1.465841605 0 -2.018746594 p.(H110H) 0.161564022 3.75E-16 -0.448488123 p.(H110I) 0.264446915 8.25E-48 -3.98728478 p.(H110L) 0.82111265 2.09E-40 -2.960914118 p.(H110K) 0.965906334 4.18E-23 -2.996887467 p.(H110M) 0.862460069 2.25E-50 -2.740398125 p.(H110F) 0.834806314 6.43E-34 -3.135084677 p.(H110P) 0.925067417 1.29E-09 -2.95105602 p.(H110S) 1.810400179 4.65E-10 -1.184258341 p.(H110T) 1.005708642 1.15E-10 -2.627504226 p.(H110W) 0.798728437 0.000906253 -2.922132316 p.(H110Y) 0.205019594 2.72E-37 -1.835976006 p.(H110V) 0.602186846 8.89E-09 -3.689305416 p.(I106A) 0.265956064 5.62E-41 -1.699621745 p.(I106R) 0.708151071 0.00753184 -2.988061683 p.(I106N) 0.574316093 5.31E-42 -0.965269067 p.(I106D) 0.82538246 1.49E-98 -2.967955761 p.(I106C) 0.691321267 4.22E-25 -0.386922853 p.(I106Q) 0.781027199 1.32E-46 -0.005916944 p.(I106E) 1.369340352 1.87E-29 -0.0975449 p.(I106G) 0.672769367 4.78E-10 -3.02336304 p.(I106H) 0.72644821 0.005177827 -3.010995827 p.(I106L) 1.113481812 3.05E-30 -0.167506702 p.(I106K) 0.981892919 3.04E-14 -2.715813562 p.(I106M) 0.330770769 2.00E-09 -0.350042819 p.(I106F) 0.866016554 6.26E-85 -2.80053284 p.(I106P) 0.882909047 2.49E-10 -4.208513597 p.(I106S) 1.419071169 1.02E-42 -1.734046648 p.(I106T) 0.202540546 0.000597084 1.952527271 p.(I106W) 0.844693893 5.38E-53 -1.788433345 p.(I106Y) 0.559852884 2.40E-20 -3.972448228 p.(I106V) 0.300607375 0 -0.304877498 p.(I145A) 0.271588442 3.48E-71 0.452383163 p.(I145R) 0.863444796 1.30E-49 -2.868807632 p.(I145N) 0.626549976 9.48E-97 -3.03399498 p.(I145D) 0.834250823 1.77E-71 -3.189549228 p.(I145C) 0.254812209 4.62E-19 0.267030724 p.(I145Q) 1.074096291 1.79E-63 -0.994618422 p.(I145E) 0.881947944 6.13E-13 -3.886239281 p.(I145G) 0.93616396 1.56E-45 -0.293042046 p.(I145H) 0.578115249 1.00E-75 -0.359487052 p.(I145L) 0.518295385 1.48E-26 -0.452515631 p.(I145K) 0.75622641 2.49E-12 -3.30974509 p.(I145M) 0.287182446 1.19E-52 0.853923859 p.(I145F) 0.668191894 1.55E-55 -0.595765894 p.(I145P) 0.70652775 5.86E-08 -2.774146577 p.(I145S) 0.340086909 2.50E-14 -1.096843518 p.(I145T) 0.376546086 4.63E-58 -0.190267925 p.(I145W) 0.336551297 5.21E-73 0.540898433 p.(I145Y) 0.454027003 5.07E-08 1.492272836 p.(I145V) 0.326600173 1.16E-08 0.083107274 p.(L105A) 0.436722631 3.01E-14 0.135476859 p.(L105R) 0.97386689 2.43E-18 -1.82812111 p.(L105N) 0.253069237 1.52E-63 -0.264482723 p.(L105D) 0.642890756 1.26E-25 -3.380062715 p.(L105C) 0.350905526 4.36E-60 -0.063665892 p.(L105Q) 0.863458838 1.35E-44 -1.817220129 p.(L105E) 0.321373345 1.62E-19 -2.783474123 p.(L105G) 0.305491908 9.33E-14 0.82123792 p.(L105H) 0.817487998 3.75E-69 -1.86839963 p.(L105I) 0.745148338 1.38E-53 -0.012071079 p.(L105L) 0.296898064 1.22E-14 0.687563414 p.(L105K) 0.831671075 6.02E-41 -2.029386497 p.(L105M) 0.258559606 3.70E-24 0.498502164 p.(L105F) 0.47780071 1.56E-30 -0.797787522 p.(L105P) 0.668584517 2.50E-68 -3.618350385 p.(L105S) 0.147525497 8.51E-26 0.370034843 p.(L105T) 0.207942829 6.00E-14 -0.378521673 p.(L105W) 0.41269219 3.69E-67 -0.100594064 p.(L105Y) 0.307223515 4.47E-38 -0.557723205 p.(L105V) 0.545440191 5.71E-25 0.825688481 p.(L108A) 0.703264294 0 0.731977195 p.(L108R) 0.139194942 2.38E-44 1.225152759 p.(L108N) 0.408153914 0.000169717 2.116888217 p.(L108D) 0.656123985 2.22E-16 0.97106299 p.(L108C) 0.320566053 9.61E-08 0.091005775 p.(L108Q) 0.397616579 1.77E-10 1.278998887 p.(L108E) 0.561757642 1.89E-13 2.025447372 p.(L108G) 0.555590801 3.17E-09 0.909631388 p.(L108H) 0.805707354 0 3.330211124 p.(L108I) 0.33133973 0.000366791 0.124116237 p.(L108L) 0.384854054 4.66E-14 0.999627151 p.(L108K) 0.517336997 1.43E-25 1.065238792 p.(L108M) 0.258652325 2.71E-07 2.272382364 p.(L108F) 0.238169444 2.51E-45 0.235765719 p.(L108P) 1.21214359 1.58E-20 -1.924011853 p.(L108S) 0.640670904 0 1.934952361 p.(L108T) 0.200519293 2.38E-43 1.77684695 p.(L108W) 0.474765397 3.77E-08 1.273489046 p.(L108Y) 0.306598677 0.00021243 0.475157182 p.(L108V) 0.39377077 1.07E-20 1.200378869 p.(L109A) 1.025855131 0 4.375481908 p.(L109R) 0.381237729 1.55E-14 2.051874653 p.(L109N) 0.531456471 1.06E-10 3.504189038 p.(L109D) 0.652626766 3.10E-14 1.545187345 p.(L109C) 0.371199737 2.86E-19 1.368174862 p.(L109Q) 0.576175121 5.05E-15 5.832054552 p.(L109E) 0.55293883 1.05E-21 1.873975818 p.(L109G) 1.189920632 1.33E-15 3.688237536 p.(L109H) 1.190248188 1.33E-15 4.516671341 p.(L109I) 0.290521917 1.76E-16 1.034736875 p.(L109L) 0.284942406 3.71E-13 1.753507365 p.(L109K) 0.602865066 2.22E-16 2.493908376 p.(L109M) 0.322554157 1.38E-15 0.757241903 p.(L109F) 0.476686297 5.00E-23 -0.796928366 p.(L109P) 1.484442133 9.64E-148 -1.601470381 p.(L109S) 0.392008193 2.01E-08 2.359383121 p.(L109T) 0.29287807 2.07E-25 2.709568431 p.(L109W) 0.241513407 0.000300082 2.116921641 p.(L109Y) 0.424334592 0.000274572 1.31412539 p.(L109V) 0.296197344 6.94E-10 1.330048096 p.(L113A) 0.701840832 1.64E-06 0.576266373 p.(L113R) 0.968206667 5.38E-08 -1.86484669 p.(L113N) 2.211343133 1.78E-15 -4.052832585 p.(L113D) 0.414166212 8.85E-11 -3.830365538 p.(L113C) 1.071233538 0 -1.00143851 p.(L113Q) 1.400571585 4.66E-57 -2.010153546 p.(L113E) 0.5099745 2.07E-44 -3.250090506 p.(L113G) 1.327606481 3.16E-96 -1.590753339 p.(L113H) 1.547536034 1.75E-18 0.234840001 p.(L113I) 0.415174517 9.88E-47 0.362584685 p.(L113K) 0.989390365 0.000302929 -2.045349359 p.(L113M) 0.288764946 1.69E-13 0.610699549 p.(L113F) 0.365235581 5.02E-121 0.258987444 p.(L113P) 0.944601978 0.011805163 -2.56167573 p.(L113S) 1.640223304 2.35E-23 0.480077603 p.(L113T) 0.842528909 1.13E-73 -0.18851867 p.(L113W) 1.29867163 1.08E-69 -2.137866239 p.(L113Y) 1.096908866 2.82E-10 -1.381362555 p.(L113V) 0.529906611 2.66E-22 0.328318619 p.(L142A) 0.782674902 0.000117258 -0.824038368 p.(L142R) 1.630281625 0 -3.171266548 p.(L142N) 1.078683817 2.35E-20 -2.076262003 p.(L142D) 1.632746232 0 -1.758028933 p.(L142C) 0.181416203 1.84E-27 -0.107062507 p.(L142Q) 0.60332335 3.04E-29 -0.374562262 p.(L142E) 1.425610943 5.01E-44 -1.460409451 p.(L142G) 1.157709712 2.54E-50 -0.951585212 p.(L142H) 0.742137285 1.11E-23 -3.221166442 p.(L142I) 0.173295039 1.47E-21 -1.499564288 p.(L142L) 0.217069374 3.68E-20 0.897533143 p.(L142K) 0.843976514 1.05E-23 -1.083265915 p.(L142M) 0.248609407 6.46E-12 0.191105128 p.(L142F) 1.077131973 1.36E-71 -2.397138466 p.(L142P) 0.209167982 9.59E-36 -2.142448037 p.(L142S) 1.539206388 4.46E-56 -2.17552402 p.(L142T) 0.578272202 3.76E-72 -2.399994224 p.(L142W) 1.349177425 5.03E-58 -1.541475586 p.(L142Y) 1.424455859 0.000123727 -2.747817664 p.(L142V) 0.732678383 2.99E-32 -0.206313335 p.(K118A) 1.277874122 2.08E-79 -1.426220483 p.(K118R) 0.401189663 4.62E-30 1.372958206 p.(K118N) 0.391119062 9.36E-16 -4.141629022 p.(K118D) 0.794386738 1.37E-49 -3.244752011 p.(K118C) 0.603167754 1.34E-33 -3.329652866 p.(K118Q) 0.435653896 4.92E-24 -1.732659939 p.(K118E) 0.563487532 3.75E-12 -4.128748171 p.(K118G) 0.631093948 7.66E-16 -3.986843301 p.(K118H) 0.196922567 1.79E-58 1.554147798 p.(K118I) 0.752750604 1.25E-32 -0.445274504 p.(K118L) 0.688762247 5.22E-05 -3.503831982 p.(K118K) 0.140715706 2.38E-31 -0.324569714 p.(K118M) 0.662082437 6.07E-07 -2.149945884 p.(K118F) 0.717434839 3.53E-35 -0.831257283 p.(K118P) 0.662270405 0.000521611 -3.698125216 p.(K118S) 0.624330493 3.61E-57 -3.731506396 p.(K118T) 0.574535366 1.63E-20 -1.726872575 p.(K118W) 0.586600979 3.00E-19 -1.780373678 p.(K118Y) 0.519608071 3.94E-86 -0.62020523 p.(K118V) 0.940251408 6.66E-16 -2.028185186 p.(K123D) 0.869143124 6.08E-11 -3.535623852 p.(K125A) 0.792190973 0 1.760551668 p.(K125R) 0.358473179 3.08E-08 1.509084165 p.(K125N) 0.215211947 1.23E-09 -0.20758416 p.(K125D) 0.368884665 1.53E-39 1.165056234 p.(K125C) 0.310454324 1.08E-06 0.100907369 p.(K125Q) 0.116290908 3.97E-40 0.960714542 p.(K125E) 0.373339055 1.67E-23 1.050049971 p.(K125G) 0.381614766 9.02E-29 2.835589478 p.(K125H) 1.016824316 0 4.279064996 p.(K125I) 0.465299357 3.91E-14 3.662323992 p.(K125L) 1.098886632 0 2.806115149 p.(K125K) 0.150666359 2.07E-14 -0.743044265 p.(K125M) 0.380715825 1.75E-11 1.590637745 p.(K125F) 1.205670198 4.44E-16 3.107871214 p.(K125P) 0.470341344 2.79E-18 0.766018746 p.(K125S) 0.536436009 0.000113587 1.895173323 p.(K125T) 0.864026716 8.88E-16 2.625613869 p.(K125W) 0.55762674 2.15E-11 2.347234665 p.(K125Y) 0.806898977 0 3.639175541 p.(K125V) 0.790853572 6.66E-16 2.216935464 p.(K128A) 0.699604663 4.44E-16 2.441436757 p.(K128R) 0.411918681 0 1.262671063 p.(K128N) 0.126654138 1.19E-17 0.227698324 p.(K128D) 0.592344774 1.90E-58 -0.472949771 p.(K128C) 1.338779542 1.78E-15 -2.225810866 p.(K128Q) 0.630535961 0 1.860367975 p.(K128E) 0.202825961 1.39E-17 -0.435546892 p.(K128G) 0.250080378 5.69E-05 1.487623933 p.(K128H) 0.241444137 5.79E-31 1.373704465 p.(K128I) 0.562365847 4.44E-16 0.443937643 p.(K128L) 0.307004339 1.54E-08 2.498693452 p.(K128K) 0.25483113 0 -0.056215536 p.(K128M) 0.217811927 4.07E-08 1.208625223 p.(K128F) 0.570488863 9.76E-28 0.803780554 p.(K128P) 0.412019166 2.72E-23 0.242091487 p.(K128S) 0.830643569 0 0.658325071 p.(K128T) 0.33058136 0.001131877 2.479725108 p.(K128W) 0.304990067 3.03E-39 -1.083628142 p.(K128Y) 0.398956303 8.28E-06 0.276719475 p.(K128V) 0.92300877 0 2.078694369 p.(F103A) 0.951292535 1.16E-06 -2.241114775 p.(F103R) 0.670366671 2.61E-17 -4.437713197 p.(F103N) 0.847924964 0.000176356 -2.132524392 p.(F103D) 0.740330318 6.63E-29 -3.776981308 p.(F103C) 1.593484503 7.13E-51 -1.177383291 p.(F103Q) 0.570317758 6.71E-32 0.13787329 p.(F103E) 0.572637531 2.23E-18 -4.111172753 p.(F103G) 1.218219398 0 -2.727236917 p.(F103H) 0.374788961 1.85E-49 -0.065898082 p.(F103I) 0.335436029 5.41E-109 1.510794712 p.(F103L) 0.974827807 4.43E-07 -0.949803636 p.(F103K) 0.636560222 0.000231686 -4.006795781 p.(F103M) 0.849535416 4.63E-11 -0.36096542 p.(F103F) 0.21695319 0 -0.28739069 p.(F103P) 0.489902643 4.60E-71 -4.207280047 p.(F103S) 0.935128949 3.92E-09 -2.4885927 p.(F103T) 0.735231795 0 -0.293726779 p.(F103W) 1.258517798 0 3.005800641 p.(F103Y) 0.495325897 6.11E-07 0.294483204 p.(F103V) 0.374974603 1.01E-18 1.173707505 p.(F137A) 0.619322114 1.62E-36 0.035076658 p.(F137R) 0.693706775 7.28E-31 -2.134613341 p.(F137N) 1.709743195 3.94E-13 -1.62810169 p.(F137D) 1.092228293 1.34E-09 -2.308488319 p.(F137C) 0.941314102 8.66E-08 -0.962694477 p.(F137Q) 1.118663112 1.74E-50 -0.113798775 p.(F137E) 0.624551642 5.21E-35 -2.867442762 p.(F137G) 0.466067462 1.16E-26 -0.42961597 p.(F137H) 0.974331884 8.68E-31 -1.508099039 p.(F137I) 0.820616957 3.05E-34 -0.562886626 p.(F137L) 1.206571446 1.59E-42 -0.146899136 p.(F137K) 1.105790948 4.12E-43 -1.179027947 p.(F137M) 0.045742221 1.48E-63 -0.984336217 p.(F137F) 0.160695461 5.34E-41 0.572835874 p.(F137P) 0.295350781 7.28E-05 1.803135651 p.(F137S) 0.938640596 4.35E-07 -2.168084967 p.(F137T) 0.819074425 0.002189473 -1.06771123 p.(F137W) 0.384759135 8.31E-29 1.537805614 p.(F137Y) 0.179229286 5.72E-38 1.56623811 p.(F137V) 0.817844294 5.50E-144 -0.251619368 p.(F141A) 0.506570124 5.72E-61 1.320181384 p.(F141R) 1.363953256 0 -2.946884665 p.(F141N) 1.842981683 9.13E-07 -1.476246281 p.(F141D) 0.49559366 0.002505373 -3.769075236 p.(F141C) 0.620661346 0 -0.454933424 p.(F141Q) 0.676822925 5.13E-76 -0.330189586 p.(F141E) 0.998991716 0 -2.949128231 p.(F141G) 1.473208054 3.93E-56 -1.160354783 p.(F141H) 0.480527673 8.08E-63 -2.798541696 p.(F141I) 0.60066948 1.07E-124 -0.60005394 p.(F141L) 0.209421818 4.01E-17 -1.10990025 p.(F141K) 0.821388807 1.47E-08 -4.083910841 p.(F141M) 0.230127619 5.19E-31 0.65644588 p.(F141P) 0.466895947 4.40E-19 -3.619366841 p.(F141S) 0.773401966 0.007695279 -0.682594176 p.(F141T) 0.434630595 5.62E-97 1.539251546 p.(F141W) 0.664005684 6.32E-24 0.094362098 p.(F141Y) 0.530253148 1.46E-78 1.166361113 p.(F141V) 0.765036031 6.25E-76 -0.004844821 p.(F143A) 1.037247957 1.67E-40 -1.082272313 p.(F143R) 0.993596057 0 -2.85867139 p.(F143N) 0.67937894 0.010063413 -2.949238844 p.(F143D) 0.915981285 1.45E-43 -2.581666275 p.(F143C) 0.508365455 2.31E-55 -2.233008895 p.(F143Q) 1.05325425 4.35E-12 -2.156150462 p.(F143E) 1.113204856 5.65E-13 -4.205704733 p.(F143G) 0.596238223 1.03E-07 -3.921096666 p.(F143H) 0.703077729 1.44E-06 -3.01417129 p.(F143I) 0.631867361 1.61E-16 -1.071397315 p.(F143L) 0.456068634 6.59E-80 -0.344158849 p.(F143K) 1.287937988 0 -2.709719831 p.(F143M) 0.426927566 1.08E-61 -0.814121359 p.(F143P) 0.720909143 1.82E-05 -3.833282295 p.(F143S) 1.222903074 0 -2.778376809 p.(F143T) 1.28723516 3.35E-05 -0.562443487 p.(F143W) 2.095480449 1.78E-15 -0.939225717 p.(F143Y) 0.380010599 1.11E-13 -0.543665338 p.(F143V) 0.937396698 1.24E-103 0.058615801 p.(F99A) 0.872281254 4.82E-07 -2.635807183 p.(F99R) 0.876964204 4.93E-10 -4.180789729 p.(F99N) 1.145935048 4.44E-16 -3.649792509 p.(F99D) 0.509664783 0.00413035 -4.653787916 p.(F99C) 1.197383467 1.53E-08 -4.035395552 p.(F99Q) 1.024135894 3.52E-09 -3.643292204 p.(F99E) 0.669021812 1.92E-06 -4.408788184 p.(F99G) 1.41962607 1.33E-15 -2.985142135 p.(F99H) 0.27947049 4.35E-12 -2.673573867 p.(F99I) 0.339601205 5.08E-43 -3.863630558 p.(F99L) 0.808161637 3.88E-53 -3.538603614 p.(F99K) 1.41590442 0 -2.906768421 p.(F99M) 1.248166857 0 -2.520315398 p.(F99F) 0.205069688 8.90E-11 -0.019461343 p.(F99P) 0.598921154 0.012331935 -3.94185093 p.(F99S) 0.838290849 7.81E-26 -1.868343676 p.(F99T) 0.728637139 0.006000965 -3.923942425 p.(F99W) 0.842916271 7.15E-47 -0.419447728 p.(F99Y) 0.374025474 4.81E-60 0.479062257 p.(F99V) 0.278809275 2.24E-66 -3.769715028 p.(S124A) 0.332424783 1.25E-57 0.303306435 p.(S124R) 1.371640487 1.93E-26 -0.674902102 p.(S124N) 0.633527578 1.13E-42 0.799380465 p.(S124D) 0.533246843 9.63E-69 1.003657606 p.(S124C) 0.808838666 1.41E-102 -0.316075989 p.(S124Q) 0.171139862 1.38E-34 0.593523732 p.(S124E) 0.989767426 5.62E-11 -0.776546397 p.(S124G) 0.228956511 1.54E-12 1.639757371 p.(S124H) 0.350802209 4.06E-05 2.057790843 p.(S124I) 0.63528277 0 2.8397482 p.(S124L) 1.165398135 0 4.719606243 p.(S124K) 0.824387802 4.09E-87 -0.376019403 p.(S124M) 0.876605372 0 2.811176311 p.(S124F) 0.390992603 8.80E-25 -0.176046962 p.(S124P) 0.70359145 3.24E-74 -0.859532081 p.(S124S) 0.236199128 0 -0.990312758 p.(S124T) 0.34110031 1.16E-09 1.009549172 p.(S124W) 0.786336331 9.51E-12 3.372725048 p.(S124Y) 0.822277686 6.37E-13 1.737373801 p.(S124V) 0.192137096 9.40E-30 1.868538094 p.(S127A) 0.410506597 0 2.323249325 p.(S127R) 0.904221382 1.69E-77 -0.359852639 p.(S127N) 0.649184199 1.35E-64 0.262774542 p.(S127D) 0.956104965 3.78E-55 0.239154278 p.(S127C) 0.68102834 1.98E-31 -0.953993543 p.(S127Q) 0.166338573 1.02E-10 0.424284712 p.(S127E) 0.79021644 5.15E-37 -0.62357022 p.(S127G) 0.611132538 4.34E-52 -0.623555458 p.(S127H) 0.261884078 3.37E-41 -0.076624157 p.(S127I) 1.012898002 0 2.73143472 p.(S127L) 0.617919027 1.95E-10 2.653730104 p.(S127K) 1.184910712 5.75E-11 0.88588897 p.(S127M) 1.328508947 0 2.742894079 p.(S127F) 0.430772885 1.67E-16 1.07518846 p.(S127P) 0.543566526 6.80E-07 0.056368749 p.(S127S) 0.013260371 1.09E-28 0.193707679 p.(S127T) 0.519581604 1.25E-12 1.302069824 p.(S127W) 0.65885583 2.22E-16 1.979890011 p.(S127Y) 0.350976761 4.63E-49 0.299876796 p.(S127V) 0.578704288 0 2.962265684 p.(S132A) 0.219891411 2.40E-09 -0.325408904 p.(S132R) 0.874107337 0.00040905 -0.641560905 p.(S132N) 0.871750987 8.27E-88 0.403430137 p.(S132D) 0.219702951 6.92E-46 0.471759315 p.(S132C) 1.427482805 1.06E-110 -1.79940565 p.(S132Q) 0.337040768 1.01E-117 0.516925348 p.(S132E) 0.618610186 2.22E-16 0.737987535 p.(S132G) 0.765906965 1.57E-83 -0.135239759 p.(S132H) 0.581197248 6.20E-66 -0.708283643 p.(S132I) 0.993177968 1.44E-08 0.610176659 p.(S132L) 0.785853377 2.26E-60 -0.042214897 p.(S132K) 0.959677541 7.51E-37 -0.480143832 p.(S132M) 0.514102544 4.01E-46 0.124886164 p.(S132F) 0.260911668 2.01E-76 -1.680096209 p.(S132P) 0.332499938 8.86E-12 -0.780468401 p.(S132S) 0.606962691 1.71E-58 0.200291213 p.(S132T) 0.786769803 6.66E-16 1.561935128 p.(S132W) 1.524695355 0 -2.175791822 p.(S132Y) 0.537363509 5.17E-33 -0.763464879 p.(S132V) 1.330821759 2.74E-112 -0.793455873 p.(S136A) 1.924487017 0 -2.970347471 p.(S136R) 1.659903169 1.13E-42 -0.530944378 p.(S136N) 0.532442425 2.30E-28 0.416993694 p.(S136D) 0.458198746 1.11E-16 0.787257806 p.(S136C) 0.639763655 7.48E-81 -0.170510862 p.(S136Q) 1.497939918 2.92E-08 -0.379754138 p.(S136E) 1.988767696 1.33E-06 -3.145522823 p.(S136G) 0.189611676 4.62E-37 1.957231224 p.(S136H) 1.332111983 9.12E-09 -1.436668403 p.(S136I) 0.987498099 8.25E-11 -2.456937498 p.(S136L) 0.632061807 4.49E-08 -5.357304485 p.(S136K) 1.638631775 2.57E-86 -1.849427789 p.(S136M) 0.397414604 8.81E-07 -4.475453253 p.(S136F) 0.213945232 8.95E-48 -2.82315951 p.(S136P) 0.837350704 0.008091096 -2.463728581 p.(S136S) 0.307917172 7.36E-51 0.451321301 p.(S136T) 0.524478507 2.44E-09 0.003784313 p.(S136W) 0.656345584 1.94E-06 -4.075024115 p.(S136Y) 0.731838021 8.01E-95 -3.72577408 p.(S136V) 0.893379402 0 -3.663104732 p.(S144A) 0.810008194 5.46E-70 -0.620216594 p.(S144R) 0.455585945 1.32E-59 -3.933142635 p.(S144N) 0.542009358 1.82E-05 -5.19795712 p.(S144D) 0.861030732 1.95E-08 -3.472488742 p.(S144C) 1.049698664 8.41E-06 -3.199029416 p.(S144Q) 0.534052356 4.74E-33 -3.819086958 p.(S144E) 0.636798245 3.00E-22 -3.302629946 p.(S144G) 1.155974114 0.000504451 -0.975336458 p.(S144H) 0.924099676 1.03E-23 -2.622851628 p.(S144I) 1.386515407 0 -2.313313513 p.(S144L) 0.843905218 0.00084337 -2.812788165 p.(S144K) 0.666338687 1.23E-07 -3.826444792 p.(S144M) 0.670758633 3.27E-10 -4.54142448 p.(S144F) 1.591707456 2.66E-15 -3.387863704 p.(S144P) 0.683419009 9.86E-17 -3.18860675 p.(S144S) 0.134132376 3.53E-24 -0.415962215 p.(S144T) 1.760904912 1.78E-15 -1.470396278 p.(S144W) 0.744076765 4.65E-20 -3.956227887 p.(S144Y) 0.486488462 1.45E-63 -2.86247596 p.(S144V) 1.905731385 3.18E-31 -1.703023146 p.(T115A) 0.063810762 1.74E-63 -0.134448229 p.(T115R) 0.531257137 4.66E-71 -0.919241658 p.(T115N) 0.194742499 2.70E-13 -1.369578395 p.(T115D) 1.120823416 2.99E-15 -1.017621026 p.(T115C) 0.903225146 8.06E-45 -0.610570797 p.(T115Q) 1.178718174 8.88E-16 0.467012457 p.(T115E) 1.040325636 0.008587597 1.046250638 p.(T115G) 0.561746709 4.31E-36 0.200479545 p.(T115H) 0.460679885 1.29E-12 -0.142258808 p.(T115I) 0.046122945 3.10E-30 -0.719252013 p.(T115L) 0.262764705 1.47E-16 -0.287491531 p.(T115K) 0.649187172 4.84E-86 -0.499887884 p.(T115M) 0.569648574 0 0.636598694 p.(T115F) 0.486082449 4.23E-06 -0.019186473 p.(T115P) 0.878805644 9.11E-116 -1.029199252 p.(T115S) 0.310291882 2.15E-50 0.571715336 p.(T115T) 0.112099535 7.64E-42 -0.097401785 p.(T115W) 0.312495203 1.01E-35 -0.621203443 p.(T115Y) 0.201618715 1.65E-35 0.079247114 p.(T115V) 0.398601599 6.18E-61 1.007907636 p.(T138A) 0.339923987 4.04E-08 0.986273518 p.(T138R) 0.842625427 1.91E-42 -1.821665209 p.(T138N) 0.995712917 9.14E-14 -0.64548067 p.(T138D) 1.205676882 2.41E-59 -1.568260991 p.(T138C) 0.918923429 2.68E-121 -0.257201025 p.(T138Q) 0.432088932 5.91E-73 -0.325980425 p.(T138E) 0.922277571 4.35E-138 -0.446168451 p.(T138G) 0.932611766 0 2.167747095 p.(T138H) 0.598734667 1.89E-69 -0.959910885 p.(T138I) 0.560118006 4.74E-61 -0.666084685 p.(T138L) 0.390054448 1.53E-74 -0.788281524 p.(T138K) 1.228587593 4.71E-73 -1.935577447 p.(T138M) 0.832102019 1.68E-16 -1.114578578 p.(T138F) 0.968552715 1.56E-68 -0.233526157 p.(T138P) 0.614728076 1.61E-67 0.035050061 p.(T138S) 0.41227096 0.0009186 0.504060205 p.(T138T) 0.178045312 3.90E-39 -1.094611824 p.(T138W) 0.80721203 0.000699962 0.43875638 p.(T138Y) 0.821118216 1.88E-65 -0.920938464 p.(T138V) 0.519263785 9.97E-54 -0.586572757 p.(T147A) 0.610740746 9.24E-64 -0.906776803 p.(T147R) 0.516832462 1.44E-13 -0.510976338 p.(T147N) 1.098335086 6.55E-08 -3.391903948 p.(T147D) 0.957587991 7.21E-42 -2.252548743 p.(T147C) 0.725618455 0.001230191 -2.761428373 p.(T147Q) 1.053661094 3.03E-127 -0.874528689 p.(T147E) 1.221260114 7.07E-100 -1.78366247 p.(T147G) 0.830933143 7.55E-64 -1.016184364 p.(T147H) 1.068701231 9.34E-39 -0.137819205 p.(T147I) 0.869183401 6.52E-19 -0.17363135 p.(T147L) 0.665897127 2.59E-28 -1.692676978 p.(T147K) 0.321121224 2.48E-53 -2.061722478 p.(T147M) 0.605503566 4.55E-29 -0.968604844 p.(T147F) 1.302317819 9.28E-14 -1.631064835 p.(T147P) 0.595557567 1.55E-56 -3.297207373 p.(T147S) 0.333061717 4.97E-27 -1.59721566 p.(T147W) 1.240863363 1.81E-50 -1.087172892 p.(T147Y) 0.256646581 4.41E-69 -1.435582227 p.(T147V) 0.501630412 1.66E-62 -0.639306375 p.(W104A) 0.678991165 4.80E-107 -0.138391464 p.(W104R) 1.411656714 0 -3.878913883 p.(W104N) 1.198835504 7.21E-74 -1.203344278 p.(W104D) 0.371697786 3.91E-12 -4.13063194 p.(W104C) 0.34824039 5.50E-15 1.735628259 p.(W104Q) 0.897881317 6.02E-20 -1.434663705 p.(W104E) 1.002443122 6.17E-21 -2.571615203 p.(W104G) 0.850104072 7.38E-46 -0.425886128 p.(W104H) 0.724954549 7.61E-07 0.256157314 p.(W104I) 0.30994381 0.001351623 0.54819537 p.(W104L) 0.426594297 0.000527557 1.106279732 p.(W104K) 1.012644191 5.55E-15 -2.824283167 p.(W104M) 0.298783402 3.94E-13 0.648811633 p.(W104F) 0.313192219 0.001244871 -0.203140246 p.(W104P) 0.621200854 1.87E-19 -4.131121698 p.(W104S) 0.805472088 7.22E-39 -1.067133065 p.(W104T) 0.532797387 4.39E-19 0.759776615 p.(W104Y) 0.302049132 2.12E-09 2.505412446 p.(W104V) 0.182785307 2.56E-12 0.665478608 p.(Y117A) 0.414837693 7.44E-41 -4.343067945 p.(Y117R) 1.087651643 0 -2.798908521 p.(Y117N) 0.310622416 1.39E-29 -3.504068618 p.(Y117D) 0.685777916 7.16E-15 -4.231236908 p.(Y117C) 0.32753546 1.06E-32 -3.980433448 p.(Y117Q) 0.627303783 1.50E-88 -3.305221807 p.(Y117E) 1.105100912 0 -3.637944655 p.(Y117G) 0.657054412 6.66E-16 -5.301317286 p.(Y117H) 0.401118928 5.55E-17 -2.676169974 p.(Y117I) 1.709702548 0 -2.541891533 p.(Y117L) 0.535730764 5.19E-05 -5.063798376 p.(Y117K) 0.889613221 0 -3.362395295 p.(Y117M) 0.537310229 4.99E-07 -3.876786456 p.(Y117F) 0.645801729 2.24E-73 -0.746455371 p.(Y117P) 0.845302613 1.70E-12 -3.104952723 p.(Y117S) 0.624088756 1.25E-37 -3.770196547 p.(Y117T) 0.635673232 4.43E-87 -3.701456517 p.(Y117W) 0.977684645 1.58E-52 -2.847808766 p.(Y117Y) 0.188825764 4.30E-36 0.82917386 p.(Y117V) 0.553559388 0.00098089 -4.403715495 p.(V102A) 0.366952636 1.23E-36 0.585192989 p.(V102R) 0.404500714 1.57E-21 -4.296048251 p.(V102N) 0.938520168 1.01E-28 -0.77791214 p.(V102D) 0.771634204 1.36E-27 -3.572355516 p.(V102C) 0.389848777 5.99E-09 1.202182352 p.(V102Q) 1.123557756 2.62E-07 0.039500031 p.(V102E) 0.826810049 1.04E-09 -3.702543843 p.(V102G) 0.778502611 4.65E-60 -0.248023513 p.(V102H) 1.561204168 1.05E-59 -1.284179733 p.(V102I) 0.076400705 5.01E-51 -0.386290833 p.(V102L) 0.28728927 1.14E-53 -0.1422301 p.(V102K) 1.012847173 0 -4.499070135 p.(V102M) 0.706411579 2.22E-16 1.028591158 p.(V102F) 0.257826669 2.89E-47 0.755211378 p.(V102P) 0.611764672 1.64E-41 -3.917113065 p.(V102S) 0.942680016 0 1.82336599 p.(V102T) 0.257122387 3.12E-92 0.313736581 p.(V102W) 0.344368137 1.27E-43 0.602741129 p.(V102Y) 0.912989521 4.13E-06 -2.656872892 p.(V102V) 0.304114332 2.71E-11 0.575160783 p.(V126A) 0.123589538 4.19E-25 -0.408136153 p.(V126R) 0.88292862 3.61E-62 -1.53038005 p.(V126N) 0.732659011 5.24E-42 -0.591733065 p.(V126D) 1.157370091 2.48E-20 0.14022886 p.(V126C) 0.878640614 1.92E-43 -0.197816846 p.(V126Q) 1.002269578 1.30E-105 0.081497534 p.(V126E) 1.089442625 9.74E-76 -0.750771842 p.(V126G) 0.538411971 1.19E-49 -0.818537652 p.(V126H) 0.96611321 2.30E-54 -0.391192362 p.(V126I) 0.395959972 9.44E-16 1.411775604 p.(V126L) 0.470208716 2.09E-06 1.611725141 p.(V126K) 0.558031783 5.89E-69 -1.109334064 p.(V126M) 0.424209283 0.000294035 0.820407745 p.(V126F) 0.859291428 0 2.498043198 p.(V126P) 1.007731589 7.34E-35 -0.348164581 p.(V126S) 0.48551182 6.08E-75 0.005749412 p.(V126T) 0.328673009 8.33E-17 0.900456759 p.(V126W) 0.76379208 1.87E-71 0.127637346 p.(V126Y) 0.392767152 1.11E-16 -0.322436719 p.(V126V) 0.916166162 4.48E-10 0.609961156 p.(V131A) 1.13949574 9.27E-36 -2.595440473 p.(V131R) 1.013595911 7.69E-74 -2.519722519 p.(V131N) 0.649161346 9.08E-08 -3.346903498 p.(V131D) 2.063422106 0 -1.843684186 p.(V131C) 1.023826584 1.42E-81 -2.620134976 p.(V131Q) 0.820877508 2.45E-11 -3.003122036 p.(V131E) 1.013260518 1.77E-33 -2.46612709 p.(V131G) 1.150197795 5.08E-05 -2.198223627 p.(V131H) 1.315553794 1.33E-15 -2.177563199 p.(V131I) 0.25084367 7.11E-28 0.807088569 p.(V131L) 0.128720026 4.77E-14 1.957792816 p.(V131K) 1.473373158 8.88E-16 -2.145304293 p.(V131M) 0.67370733 2.65E-09 1.843878149 p.(V131F) 0.165900424 1.45E-17 -0.004875403 p.(V131P) 0.985220939 0.006730916 -1.404695963 p.(V131S) 1.068510215 1.45E-44 -2.65819826 p.(V131T) 0.561102598 6.00E-33 -2.337050779 p.(V131W) 1.116010108 8.94E-13 -2.072545735 p.(V131Y) 0.646945623 1.12E-32 -0.593726469 p.(V131V) 0.172459016 2.28E-14 -0.08227594 p.(V134A) 1.385153837 2.69E-09 -1.223434398 p.(V134R) 0.514754575 4.26E-07 -4.398647337 p.(V134N) 0.538417249 1.13E-51 -3.833520005 p.(V134D) 0.721064038 4.19E-61 -3.764148428 p.(V134C) 0.7286475 1.70E-16 -0.36365082 p.(V134Q) 0.6412036 2.97E-12 -3.277440368 p.(V134E) 0.51851496 4.39E-11 -4.498330686 p.(V134G) 1.060243601 2.37E-10 -3.201355987 p.(V134H) 0.692404644 0.001789351 -3.196871929 p.(V134I) 1.016175897 2.18E-49 -0.054533676 p.(V134L) 0.280802675 2.41E-09 -0.33774142 p.(V134K) 0.97344692 0 -4.340525591 p.(V134M) 0.470395889 2.62E-58 0.920310416 p.(V134F) 0.935404996 2.83E-15 -2.901044827 p.(V134P) 0.755075645 1.42E-29 -2.748242876 p.(V134S) 1.013731919 2.80E-18 -2.398336885 p.(V134T) 0.674349247 1.31E-14 -0.995817956 p.(V134W) 0.78187212 0.000630431 -3.421384062 p.(V134Y) 0.593482644 2.00E-11 -3.790507622 p.(V134V) 0.301728539 5.55E-17 -0.048458841 p.(A165A) 0.378916765 3.32E-74 0.227920846 p.(A165R) 1.031050902 6.23E-50 -2.047906399 p.(A165N) 0.750748415 2.44E-42 -3.311124656 p.(A165D) 0.410717082 2.46E-49 -2.521131313 p.(A165C) 0.718933495 2.44E-06 -2.488773409 p.(A165Q) 1.209829025 3.17E-36 -0.893367178 p.(A165E) 1.442567176 4.44E-16 -2.271407325 p.(A165G) 0.659682083 8.37E-08 -0.114165571 p.(A165H) 0.842298535 3.34E-18 -3.329422137 p.(A165I) 1.49247281 8.66E-47 -1.366911522 p.(A165L) 0.985763187 2.09E-23 -3.017159772 p.(A165K) 0.982265351 5.60E-11 -2.256982165 p.(A165M) 0.974022926 1.07E-65 -1.385459427 p.(A165F) 1.092992715 1.12E-08 -3.624516498 p.(A165P) 1.183705214 2.22E-15 -4.411686482 p.(A165S) 0.787918861 2.13E-30 -0.862058882 p.(A165T) 1.301246375 8.03E-09 -2.405480905 p.(A165W) 1.435169726 2.71E-56 -1.371317305 p.(A165Y) 0.485744336 6.65E-26 -2.969656493 p.(A165V) 0.513200645 2.90E-16 -1.163908801 p.(A181R) 1.111622107 4.21E-29 0.193073078 p.(A181N) 0.889604482 9.56E-29 0.248531416 p.(A181D) 1.038493665 7.30E-07 -1.454076031 p.(A181C) 0.759724507 0 4.327260126 p.(A181Q) 0.632877949 6.51E-18 -0.110568173 p.(A181E) 0.737681761 8.03E-18 0.7523775 p.(A181G) 0.833711065 6.18E-42 -0.823902058 p.(A181H) 0.446935805 6.64E-14 0.740093954 p.(A181I) 0.723666953 2.42E-10 4.879980936 p.(A181L) 0.315940529 5.91E-18 1.722953336 p.(A181K) 0.672092896 3.59E-49 0.370832174 p.(A181M) 0.423982234 8.02E-69 5.956643647 p.(A181F) 0.397242851 1.47E-13 4.683526258 p.(A181P) 0.720996983 5.05E-24 -1.359144199 p.(A181S) 0.715356675 2.22E-16 1.63592058 p.(A181T) 1.188137829 4.44E-16 3.744100899 p.(A181W) 1.230205901 0 4.890632666 p.(A181Y) 0.790863299 0 2.980875422 p.(A181V) 0.341679569 3.04E-07 5.89010269 p.(A186A) 0.18858265 3.47E-17 -0.858872113 p.(A186R) 0.450000407 1.11E-16 1.757549043 p.(A186N) 0.973075475 0 1.02682727 p.(A186D) 0.389377338 9.17E-29 1.607246354 p.(A186C) 0.420630781 3.70E-101 0.609898271 p.(A186Q) 0.30614279 2.96E-10 0.202609167 p.(A186E) 0.739573476 2.22E-16 1.736298059 p.(A186G) 0.491069234 3.55E-13 2.402531081 p.(A186H) 0.481767922 1.46E-06 0.060714731 p.(A186I) 0.225395611 8.95E-09 0.028597803 p.(A186L) 0.427665831 9.12E-36 -0.488817117 p.(A186K) 0.469188022 1.86E-09 1.096939201 p.(A186M) 0.349529462 2.40E-89 0.405091994 p.(A186F) 0.889926073 6.86E-36 -0.046624249 p.(A186P) 0.735805427 4.33E-12 -0.639291611 p.(A186S) 0.307757371 3.21E-105 0.437900086 p.(A186T) 0.941943014 0 2.21815845 p.(A186W) 0.352948301 1.60E-24 0.805902074 p.(A186Y) 0.607671652 1.71E-31 -1.229381859 p.(A186V) 0.135954711 4.82E-07 0.674595063 p.(A189R) 0.12966841 1.49E-34 0.277140448 p.(A189N) 0.42683239 1.34E-27 1.240346308 p.(A189D) 0.172020986 9.41E-62 0.663896911 p.(A189C) 0.216631492 1.42E-06 2.188211617 p.(A189Q) 0.27780019 1.15E-13 1.778304018 p.(A189E) 0.282297179 1.08E-51 -1.013871999 p.(A189G) 0.381346587 1.25E-05 1.45975646 p.(A189H) 0.385696254 3.01E-12 2.239583479 p.(A189I) 0.199670947 4.81E-26 2.724882543 p.(A189L) 0.842318346 6.66E-16 2.260947535 p.(A189K) 0.555569131 2.68E-14 2.610494991 p.(A189M) 0.787370509 0 1.580805277 p.(A189F) 0.186383398 3.12E-56 0.596862444 p.(A189P) 0.177177746 4.91E-47 0.338114917 p.(A189S) 0.994196306 8.88E-16 1.639554049 p.(A189T) 0.21892934 8.52E-17 -0.216222275 p.(A189W) 0.972662688 0 2.747237291 p.(A189Y) 0.912752821 0 1.347313663 p.(A189V) 1.219876744 0 3.406526444 p.(A192A) 0.117970044 1.21E-16 0.262132549 p.(A192R) 0.672930714 3.84E-21 -1.035614304 p.(A192N) 0.768949407 3.26E-67 0.035103498 p.(A192D) 0.264165502 0.000917687 -0.413542578 p.(A192C) 0.404505832 8.48E-43 -0.750243249 p.(A192Q) 0.407858769 2.32E-33 0.366165333 p.(A192E) 0.145030715 2.16E-25 0.516381566 p.(A192G) 0.625888733 1.15E-31 0.139555214 p.(A192H) 0.96580365 1.91E-55 -0.085656037 p.(A192I) 0.851914013 2.22E-16 1.800061351 p.(A192L) 0.72675178 0 2.105052723 p.(A192K) 1.204335212 3.69E-31 -0.690292616 p.(A192M) 0.482191617 1.67E-16 2.070100671 p.(A192F) 0.570094613 2.41E-09 1.254409879 p.(A192P) 0.879745665 7.74E-42 -0.436236296 p.(A192S) 0.315606247 2.35E-32 -0.056020642 p.(A192T) 0.60817038 1.82E-37 0.810118245 p.(A192W) 0.489827998 1.07E-77 0.511689425 p.(A192Y) 0.458417454 7.16E-19 0.355832635 p.(A192V) 1.144764366 0 1.565650004 p.(R156A) 0.677591271 6.44E-70 -1.262897968 p.(R156R) 0.158555523 3.61E-28 1.180488023 p.(R156N) 0.335997121 5.76E-99 -2.486483392 p.(R156D) 0.844706931 3.88E-35 -1.977222218 p.(R156C) 1.970994371 1.78E-15 -0.460663582 p.(R156Q) 0.174455146 3.53E-14 -1.103646186 p.(R156E) 1.056363995 4.41E-64 -1.306644819 p.(R156G) 2.314755741 8.88E-16 -3.743335339 p.(R156H) 0.611518632 4.53E-25 -1.598481252 p.(R156I) 0.761390489 0.00189656 -2.006134327 p.(R156L) 0.951850975 1.64E-12 -3.080935073 p.(R156K) 0.771293633 2.49E-10 0.292222431 p.(R156M) 1.056031067 2.28E-66 -1.706989564 p.(R156F) 0.97420764 1.75E-82 -1.723705176 p.(R156P) 0.645464935 6.95E-50 -1.09989356 p.(R156S) 2.07646713 0 -4.233731369 p.(R156T) 1.195678873 6.39E-13 -1.811265528 p.(R156W) 1.205865381 5.07E-27 -1.65938287 p.(R156Y) 0.818482432 1.07E-87 -0.852483714 p.(R156V) 1.131952552 4.44E-16 -2.45863869 p.(D160A) 0.477626392 7.48E-26 -0.804730299 p.(D160R) 0.508871954 3.42E-73 -2.513722195 p.(D160N) 1.095382124 0.007098035 -1.82271294 p.(D160C) 2.721939826 2.53E-93 0.159952777 p.(D160Q) 1.014004068 5.80E-77 -0.028069455 p.(D160E) 0.528330914 4.65E-39 0.364700189 p.(D160G) 0.27938807 1.29E-38 -0.703971762 p.(D160H) 0.826917648 1.50E-22 -1.669995275 p.(D160I) 1.0027689 1.20E-19 -2.578275591 p.(D160L) 0.452298263 1.88E-30 -3.003190384 p.(D160K) 0.52433272 2.69E-70 -2.306465502 p.(D160M) 1.515708905 4.53E-10 -1.327498548 p.(D160F) 1.062909188 1.96E-11 -2.760512363 p.(D160P) 0.96375606 0.00098691 -1.474846326 p.(D160S) 1.041197714 0.001995181 0.455139346 p.(D160T) 0.940015994 3.75E-22 0.135065471 p.(D160W) 1.069302282 2.95E-13 -2.609925462 p.(D160Y) 1.310226167 1.09E-36 -2.062490485 p.(D160V) 1.423418897 6.03E-33 -1.867322901 p.(D180A) 0.459069257 0 0.172260094 p.(D180R) 0.536730541 6.11E-16 0.67519195 p.(D180N) 0.202259778 7.16E-88 -0.563444007 p.(D180D) 0.147358845 6.84E-61 0.223205547 p.(D180C) 0.326847768 1.24E-11 1.118333129 p.(D180Q) 0.487560493 1.45E-32 0.477185479 p.(D180E) 0.543347445 5.97E-42 -0.181953951 p.(D180G) 0.670069274 0 1.721370808 p.(D180H) 1.0275952 0 1.598551117 p.(D180I) 0.722670744 0 2.039396451 p.(D180L) 0.553792587 3.33E-16 1.862000497 p.(D180K) 0.287527083 0.000698892 2.059551021 p.(D180M) 0.627622127 1.90E-07 2.441186561 p.(D180F) 0.690082221 1.22E-15 1.926529698 p.(D180P) 0.662510279 9.61E-08 0.174228013 p.(D180S) 0.831565623 2.22E-16 2.166987187 p.(D180T) 0.717275427 0 2.160742172 p.(D180W) 0.640172158 4.44E-16 1.951199901 p.(D180Y) 0.176308237 5.57E-22 -0.177843458 p.(D180V) 0.584735145 0 0.536946612 p.(C157A) 0.77908508 0 1.748758407 p.(C157R) 0.389047722 7.35E-76 -0.484001882 p.(C157N) 0.189454007 1.09E-131 0.572884739 p.(C157D) 0.347977693 1.11E-16 -1.049331594 p.(C157Q) 0.177807279 8.30E-14 0.013483495 p.(C157E) 0.668679875 4.35E-41 -0.28998031 p.(C157G) 0.423193814 1.28E-71 -0.088793749 p.(C157H) 0.425772792 3.81E-07 1.063875957 p.(C157I) 0.503720513 2.35E-54 0.368230092 p.(C157L) 0.802147735 0 0.857993155 p.(C157K) 0.513526351 1.09E-17 0.609218851 p.(C157M) 0.650954886 0 1.187915039 p.(C157F) 0.682181759 0 0.720940158 p.(C157P) 0.524706613 9.17E-12 -0.579319389 p.(C157S) 0.328854338 0.000736215 0.685388861 p.(C157T) 0.301112895 1.16E-14 0.562098562 p.(C157W) 0.337854431 1.93E-13 -0.696861126 p.(C157Y) 0.650203233 0 1.370965808 p.(C157V) 0.484370108 1.11E-16 1.873630756 p.(C162A) 0.960989651 2.27E-10 -2.941001314 p.(C162R) 0.7254803 0.002615582 -3.752371044 p.(C162N) 0.990356603 4.28E-10 -2.396175162 p.(C162D) 0.600745727 1.13E-12 -3.3724854 p.(C162C) 0.08181447 1.72E-07 -0.458896683 p.(C162Q) 0.967241463 1.21E-17 -2.998773275 p.(C162E) 0.766241032 5.02E-10 -3.280730203 p.(C162G) 0.213057691 9.26E-14 -3.897927047 p.(C162H) 0.441427996 1.93E-16 -3.239363297 p.(C162I) 0.60765382 1.32E-16 -3.458403999 p.(C162L) 1.374436891 1.40E-15 0.110860444 p.(C162K) 1.36847178 1.45E-102 -1.958834424 p.(C162M) 0.61971963 1.23E-06 -4.07085933 p.(C162F) 0.367058615 5.15E-39 -2.650179634 p.(C162P) 1.554292464 0 -2.406873479 p.(C162S) 0.844884709 7.69E-56 -2.790570215 p.(C162T) 1.158836882 1.09E-14 -3.781299609 p.(C162W) 0.722585446 2.85E-25 -3.609830595 p.(C162Y) 0.285661221 8.67E-45 -2.12294804 p.(C162V) 0.958179588 2.40E-51 -3.022085579 p.(C177A) 0.779803188 2.22E-16 2.660912205 p.(C177R) 0.329119168 1.18E-32 2.732717851 p.(C177N) 0.589464609 3.93E-74 -0.369101121 p.(C177D) 0.727714568 2.90E-33 0.323273326 p.(C177C) 0.18469642 5.69E-16 -0.0290657 p.(C177Q) 0.583489146 1.12E-09 0.60529561 p.(C177E) 0.732917753 3.18E-67 0.196822277 p.(C177G) 0.568862784 1.48E-23 0.659527353 p.(C177H) 0.561022436 0 2.918936022 p.(C177I) 0.771966144 0 2.236341601 p.(C177L) 0.297419261 2.98E-08 1.325963387 p.(C177K) 0.626115411 2.22E-16 1.913947876 p.(C177M) 0.382678065 1.49E-19 0.662393494 p.(C177F) 1.187069348 0 3.831649428 p.(C177P) 0.502088299 0 0.2051135 p.(C177S) 0.32999167 9.67E-13 1.028674574 p.(C177T) 0.391285689 6.94E-58 0.147223423 p.(C177W) 0.979746023 0 2.557333889 p.(C177Y) 0.449372064 2.87E-17 3.487404337 p.(C177V) 0.732685428 2.26E-97 0.288845739 p.(Q148A) 0.889624219 9.58E-45 -0.494379486 p.(Q148R) 1.407784654 8.96E-20 -1.196336516 p.(Q148N) 1.789561287 2.66E-15 -2.381337659 p.(Q148D) 0.969372004 5.04E-18 -2.670491393 p.(Q148C) 1.226913415 7.11E-15 -2.206605159 p.(Q148Q) 0.048653373 1.96E-08 0.093270456 p.(Q148E) 0.637137694 2.48E-152 -0.628038044 p.(Q148G) 0.921264117 3.98E-123 -0.32924167 p.(Q148H) 0.955275327 1.02E-35 -2.237140592 p.(Q148I) 1.745345152 1.78E-15 -2.120100438 p.(Q148L) 0.594551183 4.12E-70 -3.031424628 p.(Q148K) 1.357291994 8.00E-57 -1.181228437 p.(Q148M) 0.847447987 0.009750386 -0.342369291 p.(Q148F) 1.261154465 0 -1.434764623 p.(Q148P) 1.225998136 1.40E-21 -0.394065131 p.(Q148S) 1.083795186 2.78E-74 0.091460507 p.(Q148T) 1.275078569 1.40E-30 -1.525977935 p.(Q148W) 1.534479308 9.73E-10 -2.511870177 p.(Q148Y) 1.290442448 1.78E-15 -3.452926557 p.(Q148V) 0.931782234 4.69E-07 -2.870920275 p.(Q172A) 0.891286915 1.79E-48 -0.508605257 p.(Q172R) 1.075675829 3.34E-54 0.22697052 p.(Q172N) 2.142272231 0 -5.137607875 p.(Q172D) 1.051898818 8.38E-24 -2.755791367 p.(Q172C) 0.868258267 5.77E-48 -0.180639144 p.(Q172Q) 0.110567189 1.36E-28 0.639449717 p.(Q172E) 0.949331598 9.54E-98 -0.595545728 p.(Q172G) 0.821507696 5.32E-123 -1.973046444 p.(Q172H) 0.686680505 3.46E-66 -0.322758133 p.(Q172I) 1.558949939 5.89E-31 -2.159122875 p.(Q172L) 1.032407938 5.16E-32 -2.316745551 p.(Q172K) 0.233823517 2.62E-49 -2.250942148 p.(Q172M) 0.638222582 2.82E-50 0.752088966 p.(Q172F) 0.73818505 1.98E-15 -3.399265698 p.(Q172P) 0.765993944 3.46E-30 -2.932269673 p.(Q172S) 0.675236901 6.73E-30 -1.656698157 p.(Q172T) 1.681192076 1.07E-107 -1.156103032 p.(Q172W) 0.889963787 8.88E-16 -3.637886698 p.(Q172Y) 0.871687883 9.38E-05 -1.539022122 p.(Q172V) 1.772772526 3.81E-62 -1.846349048 p.(E161A) 0.577646691 5.10E-35 0.715018412 p.(E161R) 0.867616494 8.28E-92 -0.300507238 p.(E161N) 0.410323225 1.60E-75 0.707111533 p.(E161D) 1.545716934 0 -3.327776333 p.(E161C) 1.257634975 2.90E-41 -1.670543761 p.(E161Q) 0.461602881 9.34E-05 1.556073348 p.(E161G) 1.025231543 5.55E-42 -3.092439616 p.(E161H) 0.423676251 1.84E-29 -0.192793058 p.(E161I) 0.827307614 0.005309676 -2.892419008 p.(E161L) 0.95107803 2.84E-23 -3.315410364 p.(E161K) 0.972702327 2.27E-33 -1.296142466 p.(E161M) 0.903969253 2.91E-40 -1.240924007 p.(E161F) 1.349559232 2.24E-33 -0.475785599 p.(E161P) 0.877942506 1.06E-162 -1.685931808 p.(E161S) 0.950251451 1.37E-27 -0.207080508 p.(E161T) 1.113758291 1.51E-85 0.320834897 p.(E161W) 1.290342434 1.69E-45 -0.003669742 p.(E161Y) 1.428653717 0.001377661 -2.250359836 p.(E161V) 0.949068658 2.64E-83 -0.488233431 p.(G152A) 0.57822563 9.26E-59 -1.346248918 p.(G152R) 0.30441722 0.000640473 -0.990646065 p.(G152N) 0.84710313 0.000871769 -0.993668346 p.(G152D) 0.948140959 5.71E-104 -2.837456224 p.(G152C) 1.143053934 2.89E-07 -2.06634027 p.(G152Q) 1.872976059 1.78E-15 -3.579262665 p.(G152E) 0.33010009 8.75E-43 -1.886731805 p.(G152G) 0.640888748 0 0.662185485 p.(G152H) 0.949282658 1.41E-34 -0.244453832 p.(G152I) 1.165796846 0.019208413 -1.081561858 p.(G152L) 0.886300538 4.18E-49 -2.344754484 p.(G152K) 0.947695677 1.41E-40 -0.516333274 p.(G152M) 0.936241412 1.01E-10 -1.783659515 p.(G152F) 0.694010567 1.51E-76 -1.418102981 p.(G152P) 0.682752065 4.00E-07 0.060357818 p.(G152S) 0.58907929 9.72E-13 -0.372774743 p.(G152T) 0.906394405 1.94E-29 -0.256594848 p.(G152W) 1.086865339 8.73E-65 -2.115292313 p.(G152Y) 0.798813968 7.98E-30 -1.197225173 p.(G152V) 0.423828421 3.80E-44 -1.847912656 p.(G154A) 0.57864254 4.10E-18 -1.257146728 p.(G154R) 1.021884138 8.39E-73 0.000234476 p.(G154N) 0.723537366 3.08E-06 -1.137084338 p.(G154D) 1.220405182 1.92E-93 -1.024486843 p.(G154C) 0.727492022 4.81E-34 -0.198326356 p.(G154Q) 1.052548655 0 -1.066178815 p.(G154E) 0.900751905 2.37E-70 -2.221768094 p.(G154G) 0.192577331 1.11E-16 0.211953995 p.(G154H) 0.728398337 1.27E-93 0.006278949 p.(G154I) 1.366582508 9.83E-45 -1.770095518 p.(G154L) 1.338645454 3.98E-45 -2.281311754 p.(G154K) 1.193471244 4.80E-11 -2.751934773 p.(G154M) 0.717087993 3.90E-47 -2.505492295 p.(G154F) 1.40020277 1.27E-10 -1.244491324 p.(G154P) 2.56762556 1.78E-15 -4.388554828 p.(G154S) 0.75387657 7.04E-56 -0.555694476 p.(G154T) 0.606670058 3.27E-61 -0.49032069 p.(G154W) 0.52050199 1.54E-85 -2.462130432 p.(G154Y) 1.548566565 2.11E-64 -1.418340596 p.(G154V) 1.715288443 1.42E-71 -1.741718023 p.(G176A) 0.677346955 7.26E-183 -0.360599069 p.(G176R) 0.778076394 0.001303761 -0.799940107 p.(G176N) 1.527327383 0 -3.201044519 p.(G176D) 0.88302154 1.88E-31 -0.39211421 p.(G176C) 1.671436756 0 -2.494425252 p.(G176Q) 0.330173772 1.45E-17 1.584568877 p.(G176E) 0.661206372 4.94E-54 -1.143888634 p.(G176G) 0.20453081 1.39E-17 -0.379808182 p.(G176H) 0.773713719 9.40E-78 -0.484388684 p.(G176I) 1.125455336 0.001250206 -2.158770263 p.(G176L) 1.228708989 2.81E-20 -1.103824402 p.(G176K) 1.073438235 2.39E-42 -0.503900013 p.(G176M) 1.011383359 4.57E-56 -2.836016192 p.(G176F) 1.233964502 2.88E-69 -1.875660756 p.(G176P) 1.144939318 1.05E-35 -1.394059256 p.(G176S) 0.692055302 0 1.423949407 p.(G176T) 0.463523453 2.55E-53 -0.927347627 p.(G176W) 0.664185942 2.18E-39 -1.285065211 p.(G176Y) 1.222402524 9.01E-36 -1.758005898 p.(G176V) 0.902317381 7.04E-07 -1.737152983 p.(G185A) 1.206791105 0 2.76796827 p.(G185R) 0.914156341 0.012126569 -1.726244143 p.(G185N) 0.592847242 2.91E-90 -0.114543061 p.(G185D) 0.86847106 9.79E-46 -0.686762399 p.(G185C) 0.414897363 2.44E-09 1.213230197 p.(G185Q) 0.420449423 2.80E-11 0.016376397 p.(G185E) 0.506498536 8.80E-48 -1.479986984 p.(G185H) 0.383954676 0 -0.088039849 p.(G185I) 0.54359633 2.93E-32 0.655078885 p.(G185L) 0.213994697 0.000119988 1.133333294 p.(G185K) 0.329328429 4.66E-63 -1.597912544 p.(G185M) 0.592556329 1.23E-17 -0.446688024 p.(G185F) 0.433302093 5.27E-74 -0.339028086 p.(G185P) 1.182987992 3.87E-56 -0.818419634 p.(G185S) 0.599734166 1.11E-16 1.301877008 p.(G185T) 0.368410676 1.09E-18 0.521668491 p.(G185W) 0.360653021 1.15E-51 -1.129172371 p.(G185Y) 0.3872403 6.58E-27 -0.524485877 p.(G185V) 0.143178853 4.52E-12 -0.802222979 p.(I151A) 0.661710194 4.11E-50 0.448327453 p.(I151R) 0.925589518 2.97E-58 -0.134181934 p.(I151N) 1.116332082 9.05E-30 -0.209975207 p.(I151D) 1.015845961 3.85E-33 -1.404549568 p.(I151C) 0.545957558 9.07E-07 -1.059795474 p.(I151Q) 1.174869543 8.56E-16 -0.296043262 p.(I151E) 0.941142277 8.67E-43 -1.353174848 p.(I151G) 0.358078673 1.45E-38 2.083203505 p.(I151H) 0.597595816 1.15E-42 0.261814026 p.(I151I) 0.200377868 4.16E-17 -0.431706003 p.(I151L) 0.316339249 8.30E-72 0.441060374 p.(I151K) 0.666584971 5.58E-66 0.299005971 p.(I151M) 0.196728505 8.87E-19 0.159305979 p.(I151F) 0.617712819 3.26E-96 -0.448484015 p.(I151P) 0.673800071 7.89E-72 -0.029661847 p.(I151S) 0.904930457 4.40E-25 0.062500353 p.(I151T) 0.336013445 4.56E-14 1.422176911 p.(I151W) 0.252476274 3.09E-71 0.258022187 p.(I151Y) 1.094831578 1.83E-23 -0.366772866 p.(I151V) 0.247447793 2.74E-14 0.581669523 p.(I164A) 0.104379693 5.61E-87 0.272334402 p.(I164R) 0.550316546 8.14E-06 -4.332964897 p.(I164N) 0.316121311 1.00E-55 -2.193206911 p.(I164D) 0.515109516 1.86E-39 0.032942294 p.(I164C) 1.093408099 1.83E-15 -0.360614934 p.(I164Q) 0.289874435 2.19E-16 1.775068618 p.(I164E) 0.652351356 8.64E-09 1.220865768 p.(I164G) 0.641220714 4.09E-23 0.342441698 p.(I164H) 0.536358777 0 1.386383942 p.(I164I) 0.33913868 4.24E-37 1.190126402 p.(I164L) 0.530402326 2.83E-60 1.215055296 p.(I164K) 0.49331596 5.75E-30 -3.817532946 p.(I164M) 0.186081373 2.11E-10 0.160559673 p.(I164F) 0.968732366 4.44E-16 1.972806641 p.(I164P) 1.008996595 2.85E-07 -1.25299972 p.(I164S) 0.442079385 4.37E-27 0.44904192 p.(I164T) 0.472428801 8.83E-38 -0.175655608 p.(I164W) 0.366142884 3.75E-07 1.058947403 p.(I164Y) 0.897401607 4.52E-10 0.191345463 p.(I164V) 0.15317692 1.69E-07 0.522195838 p.(I174A) 0.738897529 1.24E-89 -0.085850659 p.(I174R) 2.376432781 3.55E-15 0.102712591 p.(I174N) 1.597674652 1.99E-70 -1.239739814 p.(I174D) 0.369942557 3.68E-43 -4.375585445 p.(I174C) 0.354448381 1.33E-40 -0.111878034 p.(I174Q) 1.370404132 4.91E-25 -1.230824374 p.(I174E) 1.297813174 3.02E-14 -1.825647232 p.(I174G) 0.834998362 1.04E-55 -1.009076608 p.(I174H) 1.027892614 1.29E-77 -2.68731813 p.(I174I) 0.380518238 3.39E-77 1.144102761 p.(I174L) 0.299964082 6.08E-19 1.826862086 p.(I174K) 0.130576806 8.07E-111 -2.86540806 p.(I174M) 0.18326145 0 -0.525729655 p.(I174F) 0.962701121 1.90E-50 -0.064577785 p.(I174P) 1.150734226 3.86E-14 -3.855603026 p.(I174S) 0.6965313 2.44E-80 -1.60872167 p.(I174T) 1.020561112 7.29E-74 -0.579469868 p.(I174W) 0.778915791 4.60E-57 0.573863809 p.(I174Y) 0.732362076 6.82E-72 -0.189872542 p.(I174V) 0.818378164 2.07E-13 -0.63222876 p.(I178A) 0.621018277 2.08E-67 0.733797319 p.(I178R) 1.037374943 2.22E-16 -2.938299019 p.(I178N) 0.784162171 1.76E-64 -0.762170693 p.(I178D) 1.153137171 2.34E-90 -1.667933287 p.(I178C) 0.599754002 2.22E-16 1.401692731 p.(I178Q) 0.970557452 7.07E-56 -0.78217045 p.(I178E) 1.36056591 3.45E-76 -1.66684373 p.(I178G) 0.822734738 2.28E-69 -0.812431704 p.(I178H) 0.738482846 3.33E-53 0.125892268 p.(I178L) 0.680189844 0 3.86447348 p.(I178K) 1.345775238 4.37E-127 -1.642565345 p.(I178M) 0.715495668 0 2.132294722 p.(I178F) 0.368384422 1.96E-54 1.140771751 p.(I178P) 0.650243713 4.37E-86 -3.787356613 p.(I178S) 0.499646377 1.44E-19 0.660847658 p.(I178T) 0.811097792 2.16E-60 -0.427403489 p.(I178W) 0.245407245 1.70E-14 1.101581956 p.(I178Y) 0.445030879 2.36E-05 0.783141323 p.(I178V) 0.345563173 1.92E-74 0.225101238 p.(I179A) 0.89569033 7.32E-124 -0.197395111 p.(I179R) 0.328404403 4.04E-88 -1.003493659 p.(I179N) 0.24970917 4.90E-09 1.986677135 p.(I179D) 1.099818363 4.85E-63 -0.347335585 p.(I179C) 0.490093968 3.51E-11 0.640407328 p.(I179Q) 0.208626536 1.69E-38 1.102270322 p.(I179E) 0.91097508 1.01E-44 -0.350815179 p.(I179G) 0.559795885 1.30E-42 0.157464443 p.(I179H) 0.665474104 0 0.761785844 p.(I179I) 0.25652647 0 -0.65289947 p.(I179L) 0.730890389 0 0.628393441 p.(I179K) 0.995130983 7.00E-40 0.579304418 p.(I179M) 0.119554903 5.92E-11 0.575412343 p.(I179F) 0.559240379 0 0.377440894 p.(I179P) 0.961972902 1.24E-31 -1.025727675 p.(I179S) 0.349569295 7.23E-20 1.006082874 p.(I179T) 0.110287372 1.02E-113 0.672162101 p.(I179W) 0.462281716 2.34E-47 0.49880331 p.(I179Y) 0.568617935 2.89E-14 1.440167739 p.(I179V) 0.369086977 2.28E-18 0.845089908 p.(I183A) 0.198654966 2.00E-20 1.473391189 p.(I183R) 0.646151622 6.99E-24 -2.373890536 p.(I183N) 0.796921937 2.36E-41 -0.312184337 p.(I183D) 0.894655459 4.85E-24 -1.916739716 p.(I183C) 0.708928744 0 1.548682069 p.(I183Q) 0.448227316 0 0.612002062 p.(I183E) 0.710231613 1.27E-16 -0.30058938 p.(I183G) 0.548865771 1.13E-15 0.526199464 p.(I183H) 0.51856061 4.92E-23 0.349954005 p.(I183I) 0.196680071 9.51E-38 -0.284747587 p.(I183L) 0.429705546 1.11E-16 1.418292357 p.(I183K) 0.887574031 0.026296228 -0.803600583 p.(I183M) 0.441831273 0 0.620848671 p.(I183F) 0.534578329 1.05E-48 0.822702695 p.(I183P) 0.091194735 1.54E-09 0.327538399 p.(I183S) 0.532973232 2.87E-12 1.479206801 p.(I183T) 0.594282244 5.55E-16 1.420482131 p.(I183W) 0.286197922 8.21E-29 1.010296718 p.(I183Y) 0.322224628 4.59E-37 0.612547349 p.(I183V) 0.307997002 4.54E-12 0.431790976 p.(I184A) 0.949562529 8.16E-72 -0.652628723 p.(I184R) 1.645079742 8.88E-16 -2.764985696 p.(I184N) 1.09666049 5.72E-41 -0.640003161 p.(I184D) 1.430966493 1.19E-38 -1.713205949 p.(I184C) 0.563986785 3.82E-46 0.022176268 p.(I184Q) 0.788626989 3.93E-61 -0.512326004 p.(I184E) 1.005910444 5.43E-45 -1.11956496 p.(I184G) 0.619624375 1.81E-35 0.479975244 p.(I184H) 1.081027725 1.90E-55 -0.116062411 p.(I184L) 0.708651931 5.36E-57 0.017305375 p.(I184K) 0.957093896 7.28E-31 0.188421448 p.(I184M) 0.711587447 1.21E-90 0.031882845 p.(I184F) 0.74806689 1.80E-31 -0.120525839 p.(I184P) 0.757628612 1.14E-66 -0.386682078 p.(I184S) 0.723677061 1.46E-34 -0.428870144 p.(I184T) 0.264338502 5.62E-60 -0.366418732 p.(I184W) 0.563836214 1.78E-130 -0.343770497 p.(I184Y) 0.198285511 1.58E-46 0.306725636 p.(I184V) 0.109550564 5.23E-64 1.128735237 p.(K190A) 0.314953921 2.90E-31 0.301549901 p.(K190R) 0.593185127 3.90E-123 0.249878732 p.(K190N) 0.223306678 2.16E-16 0.033491741 p.(K190D) 0.778782285 4.45E-63 -0.244838455 p.(K190C) 0.692413753 2.10E-109 0.100109181 p.(K190Q) 0.395001887 1.48E-08 0.500763925 p.(K190E) 0.252076949 2.78E-17 -0.144656271 p.(K190G) 0.531597685 9.99E-49 -0.523112637 p.(K190H) 0.561343953 1.42E-33 0.855147586 p.(K190I) 0.506589274 2.03E-35 0.505076492 p.(K190L) 0.888649505 0.000179491 0.423300338 p.(K190M) 0.56887697 4.54E-13 0.832158221 p.(K190F) 0.821097499 2.35E-50 0.348407872 p.(K190P) 0.510695009 3.68E-58 0.955274312 p.(K190S) 0.540632856 2.75E-12 1.741657247 p.(K190T) 0.831073751 9.48E-16 0.520900306 p.(K190W) 1.366170082 1.36E-11 0.904734321 p.(K190Y) 1.70570494 7.67E-58 -0.907854054 p.(K190V) 0.222094725 1.55E-29 -1.070589865 p.(K193A) 0.564493775 3.60E-51 0.28552359 p.(K193R) 0.869847608 2.23E-149 -0.614099635 p.(K193N) 0.292058574 1.80E-59 -0.141472597 p.(K193D) 0.316283065 3.16E-10 1.462027374 p.(K193C) 0.456479162 9.71E-82 0.053386717 p.(K193Q) 0.205894349 2.65E-11 1.247875687 p.(K193E) 0.252183291 7.86E-49 0.295486355 p.(K193G) 0.261321462 9.89E-11 -0.359097564 p.(K193H) 0.703030184 2.00E-18 0.361022949 p.(K193I) 1.029817955 3.24E-55 -0.363870526 p.(K193L) 0.522191662 3.39E-57 0.667554074 p.(K193M) 0.545314012 3.22E-46 -0.069548271 p.(K193F) 0.125963962 1.40E-70 0.262256842 p.(K193P) 0.551775866 1.81E-79 -0.171938717 p.(K193S) 0.46312395 2.35E-11 -0.237898563 p.(K193T) 0.490225763 9.93E-47 0.197635521 p.(K193W) 0.44249631 4.31E-49 0.582382771 p.(K193Y) 0.57343566 4.31E-55 0.047935241 p.(K193V) 0.728009617 6.45E-16 -0.049236754 p.(K195A) 0.099453595 7.85E-68 1.474288201 p.(K195R) 0.211558108 0.00014017 0.868404987 p.(K195N) 0.330862825 9.83E-23 0.291451175 p.(K195D) 0.247908764 4.66E-07 0.501077532 p.(K195C) 0.105043986 2.77E-21 0.381076698 p.(K195Q) 0.140583313 6.94E-18 -0.58066783 p.(K195E) 0.092116317 2.00E-11 -0.14201554 p.(K195G) 0.491036813 2.51E-13 0.530063152 p.(K195H) 0.889835993 2.50E-66 -0.473912834 p.(K195I) 0.179077007 2.62E-53 0.81948505 p.(K195L) 0.425724407 5.10E-07 0.700703181 p.(K195M) 0.378015987 8.33E-17 -0.404098819 p.(K195F) 0.796116995 3.85E-51 0.049302506 p.(K195P) 0.171634451 2.39E-38 1.578764486 p.(K195S) 0.43581051 4.04E-36 0.024299966 p.(K195T) 0.354765202 7.68E-20 0.959070403 p.(K195W) 0.917650452 1.07E-32 0.592417082 p.(K195Y) 0.460749455 2.09E-28 -0.00935867 p.(K195V) 0.669123618 0.002488658 0.900899121 p.(K196A) 0.716630665 0 0.403527017 p.(K196R) 0.294434023 9.77E-46 0.225743049 p.(K196N) 0.33156703 0.004336765 2.220670794 p.(K196D) 0.820545677 6.66E-16 1.913899721 p.(K196C) 0.438471489 0 0.975080449 p.(K196Q) 0.384705965 4.06E-56 0.510805291 p.(K196E) 0.440328332 0 0.293137589 p.(K196G) 0.433481567 1.71E-49 1.111776935 p.(K196H) 0.44027144 0 0.216232897 p.(K196I) 0.425900226 1.08E-32 0.77863256 p.(K196L) 0.384442946 1.93E-05 0.917806226 p.(K196M) 0.467901893 3.43E-05 1.526790144 p.(K196F) 0.440495247 9.04E-06 1.040595808 p.(K196P) 0.811504969 4.44E-16 0.876168585 p.(K196S) 0.258650464 1.68E-07 0.630146893 p.(K196T) 0.268619134 4.19E-09 0.132415669 p.(K196W) 0.443404259 2.34E-15 0.236958449 p.(K196Y) 0.532187058 1.14E-09 0.128691659 p.(K196V) 0.563336379 1.11E-16 1.626508079 p.(M168A) 0.408427467 5.44E-07 0.831690685 p.(M168R) 1.114436815 0 -3.701618551 p.(M168N) 0.727181446 1.33E-59 -0.236381442 p.(M168D) 0.948634304 1.18E-14 -3.60969254 p.(M168C) 0.906353629 1.39E-47 0.075946258 p.(M168Q) 0.762729107 7.88E-63 -3.349538914 p.(M168E) 0.573769469 0.00065099 -4.29108675 p.(M168G) 0.852621774 1.16E-57 0.017169341 p.(M168H) 1.406446474 5.67E-13 -1.25321971 p.(M168I) 0.314967038 0 -0.237026748 p.(M168L) 0.149643863 3.93E-11 1.142787747 p.(M168K) 0.591797734 1.82E-61 -3.961142566 p.(M168F) 0.660000862 2.27E-78 0.071377066 p.(M168P) 0.768562814 0.024055942 -3.204930937 p.(M168S) 0.400724201 6.44E-14 1.704184669 p.(M168T) 0.153771257 4.19E-36 0.611487108 p.(M168W) 0.765057456 5.50E-31 -0.292993627 p.(M168Y) 1.514437698 8.88E-16 -1.330878671 p.(M168V) 0.22417827 6.62E-18 -0.74669276 p.(M188A) 0.601998495 1.11E-16 4.125579032 p.(M188R) 2.053172713 1.39E-23 0.347005247 p.(M188N) 0.601756941 0 1.032264452 p.(M188D) 0.607237319 1.84E-49 0.526030982 p.(M188C) 0.628864494 0 1.39449695 p.(M188Q) 0.347750072 3.44E-51 0.719024575 p.(M188E) 0.22895983 6.85E-28 -1.659704421 p.(M188G) 1.288997365 0 2.80838981 p.(M188H) 0.329086114 1.24E-38 0.931213223 p.(M188I) 0.470492748 0 -0.031274144 p.(M188L) 0.413268243 1.28E-13 2.006733307 p.(M188K) 0.588770908 2.22E-16 -2.231976119 p.(M188F) 0.08070979 3.32E-53 0.045498407 p.(M188P) 0.785526382 6.31E-11 0.024258922 p.(M188S) 0.629535576 3.33E-16 2.454793728 p.(M188T) 0.742032384 0 2.864338323 p.(M188W) 0.205261515 2.00E-29 -1.156395847 p.(M188Y) 0.88866115 5.83E-78 -0.28883084 p.(M188V) 0.557929233 5.99E-14 1.723707571 p.(M191A) 0.749207437 0 1.082610582 p.(M191R) 0.89940951 1.66E-14 0.60776099 p.(M191N) 0.761604676 2.12E-24 -0.17625872 p.(M191D) 0.3689749 2.31E-29 -0.254405726 p.(M191C) 0.491162762 8.89E-18 0.61708973 p.(M191Q) 0.738193101 8.28E-27 -0.581470507 p.(M191E) 0.753052806 4.90E-47 -0.451181752 p.(M191G) 0.635920184 3.71E-41 -0.404520192 p.(M191H) 0.303130498 9.33E-64 -0.653207288 p.(M191I) 0.06464026 6.59E-13 -0.658018819 p.(M191L) 0.696660666 4.44E-16 0.827712345 p.(M191K) 0.81785723 1.40E-29 -0.650089142 p.(M191F) 0.914405799 3.82E-69 -0.275933787 p.(M191P) 0.453859523 0.000122313 0.973184677 p.(M191S) 0.457859732 1.24E-38 -0.576349777 p.(M191T) 0.433886196 4.75E-58 -0.112747616 p.(M191W) 0.402013741 9.09E-37 0.525455814 p.(M191Y) 0.929171423 1.89E-82 -0.343560743 p.(M191V) 0.53906382 1.29E-84 0.612565329 p.(F155A) 0.371021464 8.33E-17 1.905672415 p.(F155R) 1.139787453 9.78E-62 0.086545186 p.(F155N) 0.252475307 5.87E-37 1.397883972 p.(F155D) 0.473761738 9.98E-124 0.320239187 p.(F155C) 0.638786209 3.30E-52 -0.747319856 p.(F155Q) 0.410952795 1.93E-62 0.020832443 p.(F155E) 0.752986719 5.53E-107 -0.208652857 p.(F155G) 0.287303903 3.56E-29 1.573392209 p.(F155H) 0.779717774 4.44E-53 -0.075802046 p.(F155I) 0.527869779 1.18E-54 0.723515097 p.(F155L) 0.319015115 3.84E-28 -0.369456547 p.(F155K) 0.555397683 1.67E-106 -0.250016185 p.(F155M) 0.554721043 0.000335258 0.629494552 p.(F155F) 0.15158849 6.83E-16 -0.88677273 p.(F155P) 0.706987885 1.55E-12 1.558473146 p.(F155S) 0.740261002 6.40E-45 0.393679178 p.(F155T) 0.308826611 1.21E-43 0.921335787 p.(F155W) 0.123791895 3.01E-34 0.361277154 p.(F155Y) 0.421015696 2.23E-99 -0.378236121 p.(F155V) 0.323106789 2.61E-13 0.465873111 p.(F167A) 0.212561036 8.44E-53 0.74090137 p.(F167R) 0.501166854 2.35E-20 -5.267857501 p.(F167N) 0.549987234 7.17E-88 -2.444078493 p.(F167D) 1.213437647 0 -2.470398267 p.(F167C) 0.266767387 1.90E-31 1.521509181 p.(F167Q) 0.67865338 2.14E-72 -2.081821121 p.(F167E) 1.125658436 0 -2.89566791 p.(F167G) 0.612724767 2.72E-52 0.328695803 p.(F167H) 1.581530868 0 -3.733386326 p.(F167I) 0.382594328 2.66E-21 1.790605991 p.(F167L) 0.392006129 1.88E-159 0.60288834 p.(F167K) 0.757658533 3.21E-09 -4.415333349 p.(F167M) 0.564977803 1.11E-16 0.669110416 p.(F167P) 1.425863315 4.23E-10 -2.21431304 p.(F167S) 0.426931638 8.53E-21 0.82450829 p.(F167T) 0.455358248 1.05E-14 3.661410573 p.(F167W) 0.45705696 9.46E-145 -0.842258129 p.(F167Y) 1.03672487 1.52E-52 -0.363863155 p.(F167V) 0.301587488 1.15E-08 1.358014825 p.(F171A) 0.548830387 2.11E-78 -0.490145196 p.(F171R) 0.829298036 2.00E-15 -3.872016842 p.(F171N) 1.418252111 2.07E-57 -1.564384411 p.(F171D) 0.789991125 0.001825375 -3.956620317 p.(F171C) 0.625589573 7.09E-40 -0.64511921 p.(F171Q) 1.00388029 7.51E-48 -2.450331231 p.(F171E) 0.906994563 8.01E-37 -2.892262673 p.(F171G) 0.984713761 1.72E-41 -1.286476797 p.(F171H) 0.324585153 3.08E-24 -3.434591418 p.(F171I) 0.625305197 2.23E-28 0.067244344 p.(F171L) 0.542883264 1.49E-20 0.169707206 p.(F171K) 1.628730632 4.08E-74 -1.455849525 p.(F171M) 0.366417017 4.01E-05 -0.179738858 p.(F171P) 0.686929473 6.80E-10 -3.622640791 p.(F171S) 0.76494863 3.74E-12 -1.286592593 p.(F171T) 0.932462055 2.54E-65 -0.436333471 p.(F171W) 0.189528927 2.01E-34 1.108637844 p.(F171Y) 1.167575941 2.91E-12 -0.671592593 p.(F171V) 0.503668238 3.33E-73 0.511083941 p.(F182A) 0.527508961 1.96E-07 -1.654601945 p.(F182R) 0.45578871 5.45E-89 1.164509882 p.(F182N) 1.032185515 2.03E-40 -0.272478516 p.(F182D) 0.810586833 8.35E-37 -2.298954997 p.(F182C) 0.825098499 1.91E-36 -0.338216584 p.(F182Q) 0.937825509 4.33E-35 -0.325945199 p.(F182E) 0.861577323 3.55E-43 -1.113198964 p.(F182G) 0.423873804 8.77E-96 -1.017913792 p.(F182H) 0.346317199 1.05E-62 0.156958397 p.(F182I) 0.577180858 1.13E-70 -0.19747117 p.(F182L) 0.571117542 2.14E-43 0.234509859 p.(F182K) 0.731085373 2.22E-61 0.605682535 p.(F182M) 0.637667735 5.03E-40 -0.688798294 p.(F182F) 0.225177285 0.00054693 -0.00181851 p.(F182P) 1.006892693 7.49E-102 -1.908682019 p.(F182S) 0.647555171 3.64E-77 -0.261464979 p.(F182T) 0.76604061 9.10E-61 -0.535854155 p.(F182W) 0.922201517 0 -0.418697621 p.(F182Y) 0.294118997 1.38E-15 1.078461182 p.(F182V) 1.343688135 2.50E-61 -0.590867605 p.(P163A) 0.301048676 4.29E-10 1.607599157 p.(P163R) 0.886195428 1.79E-13 -1.295894745 p.(P163N) 0.805014954 1.20E-62 -1.337877312 p.(P163D) 0.709266911 6.12E-17 -1.853482673 p.(P163C) 0.742152366 9.08E-22 -1.217523489 p.(P163Q) 0.162774946 1.51E-21 -0.247356239 p.(P163E) 0.943530075 3.83E-46 -0.244218987 p.(P163G) 0.268517906 6.28E-36 1.400010644 p.(P163H) 0.903896018 1.58E-43 0.914578972 p.(P163I) 0.828526938 2.22E-16 0.635069164 p.(P163L) 0.514456073 7.60E-91 0.266063986 p.(P163K) 1.079615032 4.87E-69 -0.091392136 p.(P163M) 0.506909362 2.22E-16 0.785229054 p.(P163F) 0.312721892 4.77E-12 0.127234964 p.(P163P) 0.266319236 0 -0.1302318 p.(P163S) 0.815829049 3.21E-41 -0.159050764 p.(P163T) 0.44994355 4.03E-54 -0.12204315 p.(P163W) 0.425520147 0.00058437 2.626081526 p.(P163Y) 0.505065055 9.71E-109 -0.089841959 p.(P163V) 0.160898981 1.14E-13 -0.08917116 p.(P194A) 0.652564729 2.44E-62 0.133878568 p.(P194R) 0.372104822 3.02E-14 -0.655959922 p.(P194N) 0.557350951 1.11E-16 -0.347676786 p.(P194D) 0.560158572 6.21E-112 -0.374057679 p.(P194C) 0.160392678 7.89E-27 -1.148980968 p.(P194Q) 0.483093506 8.29E-07 1.076366793 p.(P194E) 0.502755468 1.65E-82 -0.028195137 p.(P194G) 1.020662917 0 1.160324209 p.(P194H) 0.127320659 8.53E-59 -1.231251494 p.(P194I) 0.765501381 2.32E-102 -0.799556038 p.(P194L) 0.779452073 1.04E-11 0.649365362 p.(P194K) 0.346981371 5.50E-10 -0.769157029 p.(P194M) 0.500309882 0.000802397 -0.504707909 p.(P194F) 0.621539654 0.006108822 -0.745768782 p.(P194P) 0.085293014 1.73E-18 0.515844548 p.(P194S) 0.219154602 0.000322548 -0.069365162 p.(P194T) 0.793896033 1.50E-21 -0.110956807 p.(P194W) 0.817386519 2.91E-75 -0.727188887 p.(P194Y) 0.832544787 1.08E-88 -0.475356262 p.(P194V) 0.618444804 6.36E-123 -0.991748897 p.(S173A) 0.447266229 0 2.092103923 p.(S173R) 0.95446201 1.66E-13 -0.653351243 p.(S173N) 0.864710758 1.83E-61 -0.074621304 p.(S173D) 1.449817565 9.00E-10 -0.783308147 p.(S173C) 0.182472324 2.56E-08 2.705509723 p.(S173Q) 0.785062577 2.05E-63 -0.562454389 p.(S173E) 1.361098743 1.80E-97 -1.958489276 p.(S173G) 0.419102799 2.47E-51 -0.147798476 p.(S173H) 0.792112971 5.36E-181 -0.72004649 p.(S173I) 0.53894527 0 3.847531395 p.(S173L) 0.679134608 2.22E-16 3.16928883 p.(S173K) 1.618735507 2.04E-39 -0.155820531 p.(S173M) 0.49972386 7.87E-23 0.687015935 p.(S173F) 0.662482767 2.11E-12 1.153753417 p.(S173P) 0.488394828 2.04E-54 -0.907775358 p.(S173S) 0.620382775 3.85E-50 0.002082664 p.(S173T) 0.535427485 0 3.152611392 p.(S173W) 0.243452666 7.13E-61 0.401230896 p.(S173Y) 0.230363946 1.00E-25 1.069735394 p.(S173V) 0.920851312 0 2.975396513 p.(T149A) 0.352876436 5.55E-17 0.490981009 p.(T149R) 0.465908121 2.55E-40 0.231456692 p.(T149N) 0.697966055 2.22E-16 -0.723782025 p.(T149D) 1.63062098 3.81E-08 -0.187303758 p.(T149C) 0.586895286 1.08E-66 -0.358948394 p.(T149Q) 0.609982599 1.07E-23 1.102745996 p.(T149E) 0.605319559 1.11E-15 -0.263155838 p.(T149G) 0.6913314 1.81E-38 0.389902315 p.(T149H) 0.592324232 7.21E-21 0.3867217 p.(T149I) 0.383878862 1.52E-25 -1.642860141 p.(T149L) 0.869078829 1.32E-126 -0.581751066 p.(T149K) 0.758146783 1.66E-57 -0.453316527 p.(T149M) 0.592013752 6.64E-66 -0.361237327 p.(T149F) 1.356987924 1.12E-07 -1.569491663 p.(T149P) 1.49711465 5.09E-91 -1.709714744 p.(T149S) 0.319250016 5.48E-26 1.148936626 p.(T149W) 0.998896185 0.014947431 -1.684090313 p.(T149Y) 0.698331909 1.80E-74 -1.202713711 p.(T149V) 0.655847322 1.14E-23 -0.093290362 p.(T150A) 0.40535554 3.36E-56 0.058275699 p.(T150R) 0.180839732 0.000156011 -0.172129783 p.(T150N) 0.269424213 1.77E-05 -0.847373115 p.(T150D) 0.707919858 4.24E-94 -0.588403171 p.(T150C) 1.175210824 1.99E-62 0.225280755 p.(T150Q) 0.534214117 4.36E-54 -0.304523665 p.(T150E) 0.65282374 0.00373749 -0.874843658 p.(T150G) 0.561226041 1.11E-16 1.533312576 p.(T150H) 0.609526088 6.65E-49 0.783149532 p.(T150I) 0.32997823 1.40E-51 -1.448481968 p.(T150L) 0.651916976 8.58E-33 -1.594279652 p.(T150K) 0.479733511 5.56E-23 0.166401581 p.(T150M) 0.69784121 1.35E-55 -1.186908746 p.(T150F) 0.802119178 1.28E-27 -1.076699316 p.(T150P) 0.170347102 3.42E-68 -0.848344247 p.(T150S) 0.172929392 5.75E-40 1.113288563 p.(T150T) 0.101414263 1.20E-49 0.207161924 p.(T150W) 0.809601358 3.13E-158 -0.433793355 p.(T150Y) 1.063251905 2.89E-11 -2.613409515 p.(T150V) 0.832948741 2.44E-18 -0.575491711 p.(T159A) 0.460674582 1.41E-22 -1.142045056 p.(T159R) 1.695933974 3.29E-90 -1.849611207 p.(T159N) 0.717490644 1.25E-40 -0.594039409 p.(T159D) 1.050482834 5.76E-69 -0.405251487 p.(T159C) 1.357216034 8.67E-33 -1.778917503 p.(T159Q) 1.045427116 4.63E-54 -0.16259061 p.(T159E) 1.270653112 4.43E-13 -2.036396266 p.(T159G) 1.392113413 0 -3.362635033 p.(T159H) 1.358066032 6.65E-07 -1.373028895 p.(T159I) 0.301935197 1.55E-72 -2.175261236 p.(T159L) 1.815329716 0.109610638 -3.420864578 p.(T159K) 0.719322165 5.47E-08 -2.997911531 p.(T159M) 0.925998581 3.19E-21 -2.000255636 p.(T159F) 0.863648233 2.22E-09 -3.116654817 p.(T159P) 1.240979825 5.69E-06 -0.490391318 p.(T159S) 0.585974611 1.28E-38 0.979313407 p.(T159T) 0.211196923 3.70E-11 0.866388547 p.(T159W) 1.169074925 7.48E-25 -2.281704172 p.(T159Y) 1.150941102 2.29E-90 -1.42849933 p.(T159V) 1.513598896 5.11E-48 -1.612126333 p.(Y153A) 0.877970118 6.25E-38 -0.0859354 p.(Y153R) 0.944865532 2.93E-49 0.050795292 p.(Y153N) 0.355931612 0 0.172856737 p.(Y153D) 0.170938533 2.46E-77 -1.439528665 p.(Y153C) 0.773003103 4.08E-100 0.173998596 p.(Y153Q) 0.216691261 7.56E-13 0.812188516 p.(Y153E) 0.948729263 1.95E-17 -0.748618913 p.(Y153G) 1.122427247 1.33E-15 2.20909923 p.(Y153H) 0.223337392 0 0.061709401 p.(Y153I) 0.805946829 8.83E-21 -1.262115047 p.(Y153L) 0.809947447 1.03E-47 -0.720254672 p.(Y153K) 0.970736999 8.37E-69 -0.086857276 p.(Y153M) 0.598215967 7.36E-25 -0.266593833 p.(Y153F) 1.041504719 6.07E-67 -0.450544569 p.(Y153P) 0.907875278 6.22E-31 -0.675164577 p.(Y153S) 0.443817639 1.19E-43 1.262205407 p.(Y153T) 0.28831845 1.35E-23 0.505676972 p.(Y153W) 0.318992836 9.17E-42 0.069934497 p.(Y153Y) 0.104839761 2.29E-16 -0.930816069 p.(Y153V) 0.720673404 3.43E-44 -0.973297232 p.(V158A) 1.021888597 6.51E-21 -0.74264723 p.(V158R) 1.888011629 1.78E-15 -1.378979192 p.(V158N) 1.46334587 1.00E-90 -1.941287927 p.(V158D) 0.863740941 2.19E-36 -3.249541187 p.(V158C) 1.288112948 4.44E-16 -2.893049626 p.(V158Q) 1.355120835 4.44E-16 -3.270255848 p.(V158E) 1.107415561 4.72E-16 -2.095881831 p.(V158G) 1.539429316 0 -2.615681679 p.(V158H) 0.493512313 2.56E-08 -3.576378369 p.(V158I) 0.125476899 2.47E-25 -0.169887205 p.(V158L) 0.673259754 2.18E-116 -0.669351371 p.(V158K) 1.856967727 2.66E-15 -1.898508748 p.(V158M) 0.906511935 8.59E-42 0.150317591 p.(V158F) 0.310604685 4.11E-102 -2.470596788 p.(V158P) 0.362178874 1.99E-35 0.66551652 p.(V158S) 1.035406873 5.37E-74 -2.546304411 p.(V158T) 1.474751318 0 -4.389847174 p.(V158W) 1.542723429 5.91E-83 -0.749326436 p.(V158Y) 1.884785281 1.78E-15 -1.704451799 p.(V166A) 0.843411888 2.18E-23 -1.190226601 p.(V166R) 1.276554443 1.08E-05 -2.416553922 p.(V166N) 1.941941342 8.88E-16 -3.209360659 p.(V166D) 1.112599561 1.10E-57 -1.938810469 p.(V166C) 1.554669315 0.000238244 -1.103864012 p.(V166Q) 0.918637912 2.82E-40 -0.203166593 p.(V166E) 0.947253233 3.34E-134 -0.127080146 p.(V166G) 2.047078191 1.21E-13 -3.844721531 p.(V166H) 0.976632932 4.90E-69 -1.765036365 p.(V166I) 0.091722291 4.55E-20 -0.567420486 p.(V166L) 0.943059827 4.53E-55 -0.531422605 p.(V166K) 0.669668892 8.60E-21 -0.552831627 p.(V166M) 0.274392744 4.86E-12 0.854691717 p.(V166F) 1.079252057 1.83E-125 -2.016553451 p.(V166P) 1.412078879 0 -2.04260592 p.(V166S) 1.160024628 3.94E-26 -3.123660826 p.(V166T) 0.746895033 7.97E-22 -1.113538335 p.(V166W) 0.675311757 4.38E-11 -1.584266265 p.(V166Y) 1.091147796 0.001288893 -0.604987773 p.(V166V) 0.561655716 0 1.160428666 p.(V169A) 0.594684908 1.70E-12 -0.732069175 p.(V169R) 1.327446228 7.79E-08 -1.53358381 p.(V169N) 1.245713298 3.87E-32 -1.879750594 p.(V169D) 0.781661537 4.19E-44 -2.960847664 p.(V169C) 1.284100545 3.57E-07 -3.728310774 p.(V169Q) 1.666428312 1.69E-83 -1.359726961 p.(V169E) 1.163028087 0 -2.455404969 p.(V169G) 0.877339225 1.67E-28 -2.80717787 p.(V169H) 0.853323612 9.92E-55 -0.644684988 p.(V169I) 0.492175434 4.77E-62 0.18514351 p.(V169L) 0.307946798 1.38E-27 0.744326099 p.(V169K) 1.308423626 0.009313431 -0.664992647 p.(V169M) 0.416243097 1.65E-09 0.906453238 p.(V169F) 0.228502128 0 -0.085743382 p.(V169P) 0.779060896 0.004800115 -3.478715257 p.(V169S) 1.606179964 2.49E-07 -2.39273156 p.(V169T) 0.809329606 2.76E-96 -0.137834484 p.(V169W) 0.157145221 2.43E-17 0.301066256 p.(V169Y) 0.900461613 1.95E-25 0.252565239 p.(V169V) 0.141359567 1.39E-17 -0.057068785 p.(V170A) 0.607666574 2.68E-83 -0.824512884 p.(V170R) 1.739905871 8.88E-16 -2.882776042 p.(V170N) 1.20450989 4.32E-06 -3.443712359 p.(V170D) 0.774735119 2.45E-10 -3.962872495 p.(V170C) 0.718755724 3.61E-33 -0.557433471 p.(V170Q) 1.687460678 8.88E-16 -3.96627797 p.(V170E) 0.714955045 1.78E-31 -3.205484559 p.(V170G) 0.676634519 2.75E-26 -0.77973791 p.(V170H) 0.421442241 1.32E-97 -2.367369128 p.(V170I) 0.687651997 2.97E-54 -0.397712095 p.(V170L) 0.234450474 4.75E-14 0.452006474 p.(V170K) 0.9780071 0.015013383 -3.218146065 p.(V170M) 0.77138678 6.83E-73 -0.434583605 p.(V170F) 0.570518249 2.75E-76 -0.08619462 p.(V170P) 1.165466717 1.83E-70 -1.656238667 p.(V170S) 0.825429016 0.000101412 -3.241158488 p.(V170T) 1.21551524 7.46E-93 0.147603373 p.(V170W) 1.025597272 2.55E-30 -0.624296765 p.(V170Y) 0.799251943 5.17E-32 -1.343375219 p.(V170V) 0.221978141 1.01E-05 0.10818145 p.(V175A) 0.225925384 1.29E-37 0.16527131 p.(V175R) 0.623380264 7.81E-14 -2.791533377 p.(V175N) 1.504312123 0 -3.298051868 p.(V175D) 1.829578313 4.44E-15 -2.286711639 p.(V175C) 0.605818373 7.69E-83 -0.109361662 p.(V175Q) 0.433076944 4.52E-14 -0.124318351 p.(V175E) 1.065225511 4.54E-32 -1.238910815 p.(V175G) 0.95573838 1.41E-48 -0.645681147 p.(V175H) 0.984066744 4.39E-26 -0.661526844 p.(V175I) 0.293597838 2.06E-10 1.178786813 p.(V175L) 0.173710352 6.61E-09 1.721866885 p.(V175K) 0.984340468 0 -2.921182348 p.(V175M) 0.145618046 1.83E-40 0.75837417 p.(V175F) 0.78851112 1.19E-63 0.045301889 p.(V175P) 0.807655206 2.99E-38 -3.509167344 p.(V175S) 0.691214911 1.68E-40 -0.110074663 p.(V175T) 0.559362785 3.37E-15 0.008317709 p.(V175W) 0.597666988 1.73E-118 0.340584917 p.(V175Y) 0.596235097 0 2.236387375 p.(V175V) 0.270573661 2.72E-26 1.042956858 p.(V187A) 0.280671404 9.69E-11 0.061040353 p.(V187R) 1.507615553 4.93E-71 -1.556001757 p.(V187N) 0.7571069 5.60E-144 -0.041940962 p.(V187D) 0.05134454 9.33E-33 -4.503548208 p.(V187C) 0.766894049 5.49E-57 -0.087885056 p.(V187Q) 1.174549897 8.88E-16 -0.389347999 p.(V187E) 1.513899643 4.66E-51 -1.362567093 p.(V187G) 0.50008202 2.79E-121 -0.268751386 p.(V187H) 0.612424666 6.63E-40 0.040736032 p.(V187I) 0.363069281 1.32E-64 0.012387328 p.(V187L) 0.770977179 1.12E-47 0.173773561 p.(V187K) 0.675390185 1.34E-11 -2.275339068 p.(V187M) 0.306386193 8.33E-17 -0.599407045 p.(V187F) 0.405216693 3.75E-50 0.764958493 p.(V187P) 0.750033859 7.21E-41 -0.368265007 p.(V187S) 0.778301083 9.01E-35 -0.097302492 p.(V187T) 0.459218139 2.83E-29 0.742577452 p.(V187W) 0.58494632 1.59E-57 0.375013565 p.(V187Y) 0.465616808 3.77E-105 0.042778101 p.(V187V) 0.07361848 4.48E-09 0.128068619 p.(A207R) 0.249643684 1.14E-14 -4.062514789 p.(A207N) 0.75155691 5.82E-11 -3.373643237 p.(A207D) 0.435813676 5.60E-22 -4.626298822 p.(A207C) 0.423677321 1.19E-29 0.494023347 p.(A207Q) 2.077560632 0 -3.235299369 p.(A207E) 1.356122152 0 -4.318792957 p.(A207G) 0.414456553 6.24E-14 1.98676822 p.(A207H) 1.090742375 7.33E-33 -1.159114924 p.(A207I) 0.669864589 2.24E-39 -4.096837547 p.(A207L) 0.676838242 1.08E-123 -3.032693142 p.(A207K) 0.986805967 0.001295997 -2.679245991 p.(A207M) 0.502416281 8.29E-65 -0.151015145 p.(A207F) 0.943066555 5.72E-70 -2.249407297 p.(A207P) 0.403520167 7.63E-24 0.909860709 p.(A207S) 0.585892038 8.70E-41 0.145235123 p.(A207T) 0.897524493 0.00063292 -1.456390356 p.(A207W) 1.501013213 0 -3.778616055 p.(A207Y) 0.446780398 1.01E-39 -4.78282197 p.(A207V) 0.315162885 1.54E-71 -3.143895464 p.(A210A) 0.1660821 2.78E-17 -0.46556847 p.(A210R) 1.098166727 2.03E-22 -0.196996958 p.(A210N) 0.697085294 3.97E-17 0.92135348 p.(A210D) 0.30876482 1.19E-26 1.043646446 p.(A210C) 0.273228862 3.21E-45 0.275273156 p.(A210Q) 0.608626663 1.73E-09 -0.036401635 p.(A210E) 0.248322969 2.21E-07 0.868931668 p.(A210G) 0.283288628 2.92E-05 0.566110062 p.(A210H) 0.50491488 7.17E-68 0.041409921 p.(A210I) 1.085463098 9.99E-52 -0.312461647 p.(A210L) 0.548842793 1.10E-61 0.375049234 p.(A210K) 1.47661029 8.88E-16 -2.89582949 p.(A210M) 0.582405809 1.12E-33 0.195534377 p.(A210F) 1.158560782 5.37E-53 -0.730333418 p.(A210P) 0.595710497 1.69E-52 -3.701743375 p.(A210S) 0.275725652 9.51E-08 1.04901938 p.(A210T) 0.091486241 1.78E-33 0.902179505 p.(A210W) 0.498576462 6.94E-32 -1.414966201 p.(A210Y) 0.958389408 4.81E-20 -0.010323422 p.(A210V) 0.368550482 0.00080805 0.387050254 p.(A233A) 0.290499031 7.30E-43 0.351416565 p.(A233R) 0.929958543 1.75E-47 -0.153934028 p.(A233N) 0.633294981 2.14E-13 -0.196349824 p.(A233D) 0.92119838 7.88E-67 -2.856873311 p.(A233C) 0.743032651 2.69E-27 0.213094318 p.(A233Q) 0.33093097 5.55E-17 0.031466508 p.(A233E) 1.064633602 1.48E-35 -0.905129037 p.(A233G) 0.344486915 9.20E-69 1.660608289 p.(A233H) 0.815938807 4.44E-16 1.47633819 p.(A233I) 0.715224853 5.63E-51 0.391553636 p.(A233L) 0.972564451 4.44E-16 -0.14431038 p.(A233K) 0.44362999 1.20E-11 0.068772811 p.(A233M) 0.498776093 2.27E-53 0.367056597 p.(A233F) 0.343585982 2.13E-09 1.012502302 p.(A233P) 0.431568869 1.11E-16 1.086898982 p.(A233S) 0.256264374 5.47E-104 0.763002504 p.(A233T) 0.377200883 6.80E-18 0.579080559 p.(A233W) 0.372042647 2.74E-14 1.369464553 p.(A233Y) 0.484390694 3.45E-38 0.612123975 p.(A233V) 0.052332419 1.88E-13 -0.732432184 p.(A237A) 0.282612664 2.90E-07 -1.087870934 p.(A237R) 1.3349814 0 -4.169129117 p.(A237N) 0.662113665 0.004591664 -3.767845297 p.(A237D) 0.4824136 0 -0.896050136 p.(A237C) 0.154726069 1.91E-19 0.422053826 p.(A237Q) 0.417695156 2.77E-29 -5.324139808 p.(A237E) 0.343374742 9.02E-68 -2.97755032 p.(A237G) 0.850958984 1.36E-53 0.11655787 p.(A237H) 0.160621182 1.36E-06 -3.780984744 p.(A237I) 0.585257338 2.07E-23 -3.015274473 p.(A237L) 0.678116133 3.95E-09 -2.887788459 p.(A237K) 1.524806115 0 -3.786747941 p.(A237M) 1.347782094 0 -1.951002303 p.(A237F) 1.10674354 0 -3.019531436 p.(A237P) 0.598585966 4.87E-78 -3.113000761 p.(A237S) 1.025234115 3.43E-18 0.369568581 p.(A237T) 1.779806054 8.88E-16 -3.909697096 p.(A237W) 0.791552806 0.006446486 -2.748804721 p.(A237Y) 0.924254248 0 -3.315110777 p.(A237V) 0.395161126 2.21E-58 0.120418598 p.(R197A) 0.434038101 5.18E-72 1.105865808 p.(R197N) 0.98626397 0 1.415310422 p.(R197D) 0.877716542 0 1.556667615 p.(R197C) 0.464176713 1.67E-16 1.61471376 p.(R197Q) 0.298696339 4.15E-11 0.654308628 p.(R197E) 1.082359159 0 2.397938798 p.(R197G) 0.206203032 1.16E-22 0.551896178 p.(R197H) 0.589570109 3.33E-16 0.88227735 p.(R197I) 0.362879811 3.58E-31 0.743812711 p.(R197L) 0.748800629 4.44E-16 0.861301412 p.(R197K) 0.583141484 1.86E-15 0.847076003 p.(R197M) 0.510608773 2.05E-31 0.752676662 p.(R197F) 0.29411722 5.83E-31 0.564734088 p.(R197P) 0.517138937 1.52E-12 -0.000394174 p.(R197S) 0.525812744 0 0.854324886 p.(R197T) 0.368065161 3.94E-08 1.086678669 p.(R197W) 0.49740388 3.23E-44 0.129308126 p.(R197Y) 0.588649118 0 1.196005614 p.(R197V) 0.673581479 3.33E-16 0.697954585 p.(R212A) 0.591142876 1.98E-63 -0.369930333 p.(R212N) 0.36822343 2.22E-24 1.725701697 p.(R212D) 0.831715787 1.12E-88 -0.154520124 p.(R212C) 0.178373872 1.64E-35 0.165320668 p.(R212Q) 0.669561911 0 1.846373668 p.(R212E) 0.400334316 4.73E-13 0.170288863 p.(R212G) 1.546028997 2.16E-89 -1.870848957 p.(R212H) 0.585077846 0 0.927885262 p.(R212I) 0.417234832 8.91E-69 -0.438903827 p.(R212L) 0.486804117 1.52E-46 0.510321548 p.(R212K) 0.252915475 6.34E-23 2.484907835 p.(R212M) 0.227841101 2.22E-16 -0.506716002 p.(R212F) 0.415735331 5.96E-80 -0.253618142 p.(R212P) 0.919950363 5.30E-08 -2.828601278 p.(R212S) 0.650347268 4.76E-52 -1.141010622 p.(R212T) 0.786171714 1.39E-140 -0.937569151 p.(R212W) 0.78345418 8.90E-30 -0.48889485 p.(R212Y) 0.808830425 3.12E-15 -0.209209437 p.(R212V) 0.437823288 1.45E-81 0.196458779 p.(R221A) 1.043588133 1.24E-10 -4.114337439 p.(R221R) 0.313319915 1.27E-14 1.493410841 p.(R221N) 1.360747682 0 -3.990289839 p.(R221D) 1.609040701 1.78E-15 -3.529811667 p.(R221C) 0.527592587 2.41E-09 -5.171105481 p.(R221Q) 0.605791905 3.12E-05 1.904754585 p.(R221E) 1.136941671 0 -3.679118592 p.(R221G) 0.714986087 1.56E-08 -3.223297 p.(R221H) 0.872573288 6.79E-05 -3.14330205 p.(R221I) 0.756666518 1.72E-41 -3.611304351 p.(R221L) 0.915039777 3.03E-13 -3.412024795 p.(R221K) 0.888286986 5.59E-30 -3.266150572 p.(R221M) 0.18704906 2.27E-79 -2.032097927 p.(R221F) 0.447078962 8.36E-19 -3.522155473 p.(R221P) 0.898774752 0.007452775 -3.682214113 p.(R221S) 0.461240368 4.46E-29 -2.76295424 p.(R221T) 0.643797988 2.55E-20 -3.353056253 p.(R221W) 0.276927679 5.58E-58 -3.950835318 p.(R221Y) 1.247096502 7.77E-14 -5.37170083 p.(R221V) 0.617957402 7.22E-34 -3.043576582 p.(R226A) 0.632229036 3.66E-34 0.012358136 p.(R226R) 0.112840322 9.82E-92 1.271117988 p.(R226N) 0.498364496 4.87E-94 0.752860646 p.(R226D) 0.578932692 9.38E-40 0.799407796 p.(R226C) 0.502982156 0.000290305 1.70131008 p.(R226Q) 0.920274912 1.56E-10 -0.322045222 p.(R226E) 0.755656366 0 1.687756727 p.(R226G) 0.584267269 0 1.202869749 p.(R226H) 0.328608276 3.63E-12 1.264612832 p.(R226I) 0.913245891 0 1.759531296 p.(R226L) 0.756464695 0 1.558627895 p.(R226K) 0.231388761 8.50E-29 1.310753535 p.(R226M) 0.599308149 5.93E-45 0.118943126 p.(R226F) 0.886133021 2.35E-33 -0.198592817 p.(R226P) 0.310401689 8.87E-13 0.681803347 p.(R226S) 0.263845554 0.001142454 0.448426897 p.(R226T) 0.639041216 1.14E-22 -0.47541622 p.(R226W) 0.359643843 0.000189981 0.137396895 p.(R226Y) 0.417030165 1.25E-26 -0.092940228 p.(R226V) 0.36267002 1.74E-97 1.518703574 p.(R236A) 0.600705085 1.24E-69 0.376720171 p.(R236N) 0.98542563 5.66E-19 0.243153378 p.(R236D) 1.087288421 1.82E-73 -1.362575831 p.(R236C) 0.543398627 9.88E-36 -0.286066006 p.(R236Q) 0.32957201 2.04E-07 1.017267772 p.(R236E) 0.595702884 3.50E-44 0.334961261 p.(R236G) 0.126422875 1.40E-65 -0.365858812 p.(R236H) 0.762153663 4.44E-16 -0.250452657 p.(R236I) 0.839074898 1.25E-46 -0.943321694 p.(R236L) 0.811109667 2.31E-10 -3.452372074 p.(R236K) 0.535150265 1.11E-16 0.615197735 p.(R236M) 0.75101357 1.73E-40 -0.05471274 p.(R236F) 0.725349939 1.05E-59 -0.562329815 p.(R236P) 0.819324665 3.96E-14 -2.746389677 p.(R236S) 0.170599146 1.75E-08 1.428329955 p.(R236T) 0.386539323 1.05E-20 0.550329412 p.(R236W) 0.641015977 1.43E-41 -0.192906158 p.(R236Y) 0.682103591 8.04E-85 0.26741446 p.(R236V) 0.969731171 2.03E-24 0.485305677 p.(R243A) 0.235117734 1.14E-14 0.53440264 p.(R243R) 0.247558532 4.72E-30 0.875568134 p.(R243N) 0.384959542 2.41E-14 -1.988894406 p.(R243D) 0.286761969 1.13E-27 -0.775375406 p.(R243C) 0.09156974 4.07E-69 -0.355794004 p.(R243Q) 1.188245073 0 1.364119732 p.(R243E) 0.643638158 4.71E-40 -0.11940379 p.(R243G) 0.629725089 3.33E-16 0.562811617 p.(R243H) 0.485009056 1.11E-16 0.308877903 p.(R243I) 0.406179273 3.25E-57 -0.044264294 p.(R243L) 0.94831534 2.83E-111 -0.289040291 p.(R243K) 0.292026423 1.26E-12 0.937964057 p.(R243M) 0.842566216 2.53E-58 0.197467631 p.(R243F) 0.381356231 3.60E-49 0.309646845 p.(R243P) 0.583857546 1.11E-16 1.160860801 p.(R243S) 0.249827866 1.90E-07 -0.028421856 p.(R243T) 0.372678669 3.20E-39 1.235427485 p.(R243W) 0.216345193 1.54E-15 0.710075049 p.(R243Y) 0.952829233 6.66E-16 1.550974309 p.(R243V) 0.194308383 7.79E-26 0.665614276 p.(N198A) 0.154648905 1.25E-32 0.75576732 p.(N198R) 0.181469908 4.87E-49 1.227789261 p.(N198N) 0.296515643 0 0.293996803 p.(N198C) 1.030107372 0 2.041149345 p.(N198Q) 0.690162518 4.44E-16 1.692699972 p.(N198E) 1.219248011 0 1.883101917 p.(N198G) 0.735936289 0 1.62626467 p.(N198H) 0.621858877 7.12E-38 0.027764223 p.(N198I) 0.403150184 9.46E-05 1.409974225 p.(N198L) 0.331294364 2.55E-37 0.710036158 p.(N198K) 0.332221216 6.35E-15 1.341795041 p.(N198M) 0.580734948 0 1.399624658 p.(N198F) 0.46881915 3.79E-57 0.610571777 p.(N198P) 0.246781551 1.06E-07 1.007252817 p.(N198S) 0.473289406 2.64E-11 0.973413593 p.(N198T) 0.269727541 2.56E-25 0.08799072 p.(N198W) 0.625189215 7.17E-40 -0.263008443 p.(N198Y) 0.295430357 1.12E-126 0.667598955 p.(N198V) 0.37543784 3.25E-13 0.477363921 p.(N206A) 0.439035236 4.47E-40 0.218648816 p.(N206R) 0.709734543 9.28E-61 0.688831958 p.(N206N) 0.216288754 0 -0.21143073 p.(N206D) 0.501962276 6.39E-85 0.583110929 p.(N206C) 0.671676516 2.48E-46 -0.334925533 p.(N206Q) 0.242049531 1.02E-18 1.000606194 p.(N206E) 1.42920507 0 1.748887281 p.(N206G) 0.837628794 3.45E-50 -1.778374728 p.(N206H) 0.472514303 9.70E-12 1.296710904 p.(N206I) 1.19174914 7.33E-31 -0.400151519 p.(N206L) 1.267230153 0 -2.891061776 p.(N206K) 0.141535494 4.06E-22 -0.592476208 p.(N206M) 0.766694604 4.94E-138 -0.099228383 p.(N206F) 0.768892033 5.89E-56 -0.175716491 p.(N206P) 0.89174733 6.40E-32 -0.545491432 p.(N206S) 0.234398405 0 0.096012828 p.(N206T) 0.430470957 2.31E-22 0.147865078 p.(N206W) 0.913899754 1.49E-67 -0.467972562 p.(N206Y) 1.426742996 1.29E-23 1.019353945 p.(N206V) 0.848468724 1.07E-60 0.081466566 p.(N224A) 0.56935209 0 1.221259876 p.(N224R) 0.534766923 1.09E-49 1.078989986 p.(N224D) 0.288738149 6.87E-28 0.762266473 p.(N224C) 0.463152142 1.43E-69 0.026760411 p.(N224Q) 0.874213269 0 1.732632992 p.(N224E) 0.606084394 0 0.573406589 p.(N224G) 0.488920626 7.39E-58 0.315679434 p.(N224H) 0.504399294 3.32E-25 0.464780195 p.(N224I) 0.36445321 1.17E-27 0.158734093 p.(N224L) 0.158291639 6.31E-63 0.772371458 p.(N224K) 0.556544235 1.78E-09 0.300789461 p.(N224M) 0.330391213 1.94E-07 -0.230606293 p.(N224F) 0.348334853 2.39E-23 -0.243160923 p.(N224P) 0.348184461 1.45E-07 0.797915983 p.(N224S) 0.279796769 1.33E-12 0.540331676 p.(N224T) 0.416118423 4.39E-26 0.98177958 p.(N224W) 0.853248258 1.62E-21 -0.674523945 p.(N224Y) 0.622383442 5.29E-62 0.130735476 p.(N224V) 0.79113597 6.18E-139 -0.590937197 p.(D213A) 0.170421452 4.92E-77 1.744932475 p.(D213R) 0.221729653 1.80E-28 2.84692725 p.(D213N) 0.34826934 1.20E-65 1.646266726 p.(D213C) 0.490477351 1.17E-14 1.192464718 p.(D213Q) 0.806342873 0 2.145147557 p.(D213E) 0.207729394 1.14E-07 2.099767395 p.(D213G) 0.21651038 4.55E-67 2.143254324 p.(D213H) 0.215067539 1.37E-07 1.551144525 p.(D213I) 0.368711638 1.35E-10 -3.432004304 p.(D213L) 0.800982191 4.01E-12 0.319373896 p.(D213K) 0.819976451 0 2.401339065 p.(D213M) 0.23037108 1.18E-41 1.455140802 p.(D213F) 0.719686346 2.81E-31 0.260532314 p.(D213P) 0.620563206 2.66E-35 -2.974897782 p.(D213S) 0.555774978 6.66E-16 1.29553904 p.(D213T) 0.84740795 2.43E-38 0.576358848 p.(D213W) 0.647963018 1.49E-26 0.422111531 p.(D213Y) 0.192799689 9.64E-13 -0.697211121 p.(D213V) 1.559273127 1.88E-31 -1.416425103 p.(C217A) 0.371935877 0 1.727205413 p.(C217R) 0.830171605 6.04E-17 0.304518316 p.(C217N) 0.222478599 2.22E-108 0.722207654 p.(C217D) 0.482988424 1.43E-61 -1.190275613 p.(C217Q) 0.494822182 7.70E-45 0.728380867 p.(C217E) 1.114688712 2.31E-23 -0.485301023 p.(C217G) 0.792420716 8.70E-67 -1.738253391 p.(C217H) 0.828710588 3.79E-37 0.301116392 p.(C217I) 0.555886697 1.87E-28 -0.25567673 p.(C217L) 0.859623812 6.83E-82 0.188097183 p.(C217K) 0.19174842 5.70E-21 0.391974123 p.(C217M) 0.64457857 7.09E-63 0.427768262 p.(C217F) 0.419444444 5.33E-80 0.011287236 p.(C217P) 1.20934931 4.44E-16 -4.352029701 p.(C217S) 0.54859323 3.33E-16 1.467393988 p.(C217T) 0.929349169 8.69E-116 0.080618244 p.(C217W) 0.765401785 1.06E-70 -0.450730912 p.(C217Y) 0.573212673 4.55E-08 -0.038718957 p.(C217V) 0.633336467 6.17E-70 0.972812992 p.(Q238A) 0.373098947 8.05E-57 0.946617362 p.(Q238R) 0.413319374 8.07E-59 1.035398936 p.(Q238N) 0.55667191 1.10E-31 0.776241069 p.(Q238D) 1.039401048 3.57E-80 -1.910893332 p.(Q238C) 0.722111022 6.04E-43 0.26574427 p.(Q238E) 0.50675822 1.33E-12 0.763473589 p.(Q238G) 0.43339319 5.37E-21 0.466434271 p.(Q238H) 0.365999525 3.82E-12 0.45968419 p.(Q238I) 0.492324132 0.002644202 0.608423891 p.(Q238L) 0.1703697 2.82E-08 0.129107647 p.(Q238K) 0.28511672 1.71E-14 0.477494051 p.(Q238M) 0.795719826 9.20E-12 0.86721445 p.(Q238F) 0.254432123 6.57E-22 1.522092417 p.(Q238P) 0.679226037 2.67E-53 -4.232547214 p.(Q238S) 0.520618156 1.54E-13 0.556528076 p.(Q238T) 0.290853322 0.000122603 0.753706499 p.(Q238W) 0.231897527 7.86E-57 0.670277128 p.(Q238Y) 0.281568366 1.49E-92 -0.114987432 p.(Q238V) 0.351911184 6.60E-11 1.301599155 p.(E199A) 0.488847874 2.69E-08 1.538932528 p.(E199R) 0.574610615 2.12E-07 1.497710273 p.(E199N) 0.486244497 0 1.367105327 p.(E199D) 0.390049786 0 0.636934238 p.(E199C) 0.239774461 2.25E-41 1.023030265 p.(E199Q) 0.290605328 4.34E-36 0.631485579 p.(E199E) 0.125558304 3.27E-08 -0.425161398 p.(E199G) 0.353957744 1.22E-45 1.601643259 p.(E199H) 0.366171079 2.01E-27 1.420068802 p.(E199I) 0.96010678 2.71E-95 -0.209149942 p.(E199L) 0.756919992 9.87E-07 0.514914912 p.(E199K) 0.595105226 2.84E-08 0.607802501 p.(E199M) 0.487541962 0.000147944 0.706329292 p.(E199F) 0.64824543 1.73E-31 -0.059107502 p.(E199P) 0.294459967 2.31E-50 1.214662633 p.(E199S) 0.254472024 8.94E-10 1.022961504 p.(E199T) 0.531243946 1.19E-13 0.576514421 p.(E199W) 0.763732212 5.02E-31 0.199503998 p.(E199Y) 1.196076396 2.20E-31 0.616810279 p.(E199V) 0.591705343 9.96E-28 -0.101796646 p.(E232A) 0.405042831 1.47E-12 1.268573516 p.(E232R) 0.86140939 1.36E-16 0.343233564 p.(E232N) 0.780523263 7.47E-08 1.500490745 p.(E232D) 0.135325382 8.32E-27 -0.404213454 p.(E232C) 0.333131123 5.11E-06 1.211586338 p.(E232Q) 0.180635605 1.12E-06 -0.04168791 p.(E232E) 0.128825226 7.37E-42 -0.302573538 p.(E232G) 0.595776515 2.22E-16 0.924551966 p.(E232H) 0.776225016 0 1.437346787 p.(E232I) 0.384464504 5.47E-56 0.692498753 p.(E232L) 0.651234561 1.11E-12 1.005293316 p.(E232K) 0.515762717 1.17E-56 1.418761585 p.(E232M) 0.544682872 5.67E-66 0.00493212 p.(E232F) 0.489012753 2.32E-15 0.420291901 p.(E232P) 0.288845462 1.94E-17 1.188821463 p.(E232S) 0.319978229 1.31E-34 1.569692035 p.(E232T) 0.658711057 6.63E-10 1.705882237 p.(E232W) 0.836268425 0 1.141269398 p.(E232Y) 0.674499826 2.94E-33 1.042170436 p.(E232V) 0.603863342 0 0.63557719 p.(G214A) 0.383731374 2.70E-06 1.204935768 p.(G214R) 0.332799704 1.03E-11 1.611695377 p.(G214N) 0.369717414 1.03E-19 1.218855453 p.(G214D) 0.145426895 6.94E-18 -0.647511533 p.(G214C) 0.81165331 1.28E-34 0.490000119 p.(G214Q) 0.309073945 7.84E-08 1.906026659 p.(G214E) 0.346650309 0.00098677 1.395808733 p.(G214G) 0.241413249 2.40E-13 0.196776388 p.(G214H) 0.63342499 0 1.798580895 p.(G214I) 0.889628225 1.24E-22 -2.554275454 p.(G214L) 0.714910018 1.33E-58 0.412755482 p.(G214K) 0.447836638 2.59E-07 1.987067735 p.(G214M) 0.448244267 0 0.201834127 p.(G214F) 0.812270309 4.46E-07 0.041574413 p.(G214P) 0.677739548 1.00E-24 -3.821578859 p.(G214S) 0.635463826 3.33E-16 1.172983274 p.(G214T) 0.315270589 1.11E-16 2.16361341 p.(G214W) 1.087806216 5.23E-89 -0.253018111 p.(G214Y) 1.701550145 4.50E-13 -0.873468967 p.(G214V) 2.442255579 0 -5.408403424 p.(G223A) 0.355104118 6.33E-05 0.543714797 p.(G223R) 0.420961156 2.01E-17 1.8708427 p.(G223N) 0.401181089 3.53E-12 -0.006165133 p.(G223D) 0.276001989 3.94E-39 0.778268417 p.(G223C) 0.841063653 0 0.701449118 p.(G223Q) 0.51224364 7.14E-99 0.373697249 p.(G223E) 0.860305102 6.46E-07 -0.846524904 p.(G223H) 0.376862938 2.33E-86 -0.282306211 p.(G223I) 0.308210153 3.71E-60 0.302608745 p.(G223L) 0.285227168 4.45E-07 -0.112374413 p.(G223K) 0.959608107 4.44E-16 0.823416828 p.(G223M) 0.72493063 5.82E-14 0.990000519 p.(G223F) 0.679887566 2.86E-53 0.079979426 p.(G223P) 2.052191855 0 -3.922317358 p.(G223S) 0.465925465 1.24E-31 1.060923181 p.(G223T) 0.358705461 5.08E-09 1.064123804 p.(G223W) 0.478918987 6.25E-52 -0.356110927 p.(G223Y) 0.763350539 3.12E-37 -0.405400994 p.(G223V) 0.447982713 4.81E-25 0.625514634 p.(H205A) 0.270254679 2.33E-29 0.707321137 p.(H205R) 0.248024085 4.31E-13 1.275827717 p.(H205N) 0.195513457 0.000173646 0.701393338 p.(H205D) 0.730484307 0 2.290741537 p.(H205C) 0.653843417 1.96E-21 -0.075532684 p.(H205Q) 0.299761649 0.00011083 1.574439399 p.(H205E) 1.020937896 8.88E-16 2.441501919 p.(H205G) 0.636771536 6.10E-05 -0.98878431 p.(H205H) 0.151796501 3.16E-47 -0.286518698 p.(H205I) 1.1191437 2.61E-14 -0.506549946 p.(H205L) 0.541564194 1.13E-15 -0.850994731 p.(H205K) 0.345830858 1.14E-40 2.816896823 p.(H205M) 0.322611265 6.81E-23 0.138186569 p.(H205F) 1.105818857 3.10E-27 -0.303957626 p.(H205P) 0.699476515 5.42E-68 0.258831642 p.(H205S) 0.404590529 6.62E-41 1.528412282 p.(H205T) 0.795915476 1.70E-24 0.706979896 p.(H205W) 0.497891605 2.33E-05 -0.006185687 p.(H205Y) 0.65247929 4.32E-66 0.031121875 p.(H205V) 0.829568388 4.85E-50 0.114981947 p.(H229A) 0.183331495 6.46E-69 0.820013565 p.(H229R) 0.322526498 9.31E-44 1.077719713 p.(H229N) 0.422509219 1.06E-09 0.40794126 p.(H229D) 0.633492535 0 1.262421757 p.(H229C) 0.244654617 6.20E-14 0.892844211 p.(H229Q) 0.478541439 0 0.566667772 p.(H229E) 0.365957487 2.37E-57 0.134403205 p.(H229G) 0.939820832 2.08E-09 -0.069773338 p.(H229H) 0.089286501 4.88E-21 0.047315664 p.(H229I) 0.407387912 8.41E-10 -0.288777824 p.(H229L) 0.236363474 1.54E-07 1.097357892 p.(H229K) 0.206206321 1.34E-30 0.868143481 p.(H229M) 0.342339709 1.53E-89 0.82766225 p.(H229F) 0.492637747 6.87E-64 0.601225598 p.(H229P) 0.670885779 6.86E-14 1.060921112 p.(H229S) 0.80460293 0 0.769704573 p.(H229T) 0.348888988 5.83E-29 0.594024227 p.(H229W) 0.510515277 1.11E-16 1.190101595 p.(H229Y) 0.163730516 1.39E-17 -1.033976466 p.(H229V) 0.67316299 0 1.679630059 p.(H234A) 0.579061991 2.14E-28 0.681442738 p.(H234R) 0.428610566 3.22E-06 1.071208108 p.(H234N) 0.602379897 0 1.432922757 p.(H234D) 0.221393696 5.04E-09 -0.0210429 p.(H234C) 0.108443721 2.65E-15 0.553610772 p.(H234Q) 0.485146009 1.08E-35 0.501088034 p.(H234E) 0.730199095 0 1.384316199 p.(H234G) 0.506368619 1.85E-62 0.722982229 p.(H234I) 0.635735717 1.82E-08 0.403107977 p.(H234L) 0.388564762 5.55E-17 -0.790030766 p.(H234K) 0.431818514 1.44E-22 0.226390563 p.(H234M) 0.826683471 1.41E-60 0.537427389 p.(H234F) 0.704616225 0.007332376 0.899892575 p.(H234P) 0.961296077 5.08E-42 -2.606648242 p.(H234S) 0.241520771 6.38E-75 0.958392446 p.(H234T) 0.35034908 4.59E-48 0.923679623 p.(H234W) 1.012261691 7.34E-29 -0.54577247 p.(H234Y) 0.141524348 6.94E-18 -0.885467151 p.(H234V) 0.424813968 2.78E-16 0.527566808 p.(I209A) 0.844201347 1.06E-21 -3.496535035 p.(I209R) 0.648332089 2.80E-53 -4.126969694 p.(I209N) 0.783815505 2.49E-10 -4.569608155 p.(I209D) 0.609050801 3.19E-31 -4.612559693 p.(I209C) 0.83791894 1.23E-106 -0.356175923 p.(I209Q) 0.96860858 2.20E-54 -2.754124418 p.(I209E) 0.856207064 1.51E-13 -2.101476697 p.(I209G) 0.658021161 7.74E-29 -3.531556528 p.(I209H) 0.634915175 1.57E-134 -2.807833753 p.(I209I) 0.149657391 1.10E-25 0.857820622 p.(I209L) 0.560705119 8.80E-47 -0.222750768 p.(I209K) 0.544825437 5.52E-31 -3.20453046 p.(I209M) 0.795442853 6.20E-81 0.037047908 p.(I209F) 0.630054051 2.20E-06 -4.64173847 p.(I209P) 0.382846561 1.32E-15 -4.014939202 p.(I209S) 0.800594099 2.38E-41 -3.299790242 p.(I209T) 1.555616708 5.81E-60 -1.998461297 p.(I209W) 0.505915818 1.42E-06 -4.930265907 p.(I209Y) 0.576562287 4.93E-41 -4.405644464 p.(I209V) 0.406393094 4.11E-12 1.146801832 p.(I244A) 0.703313255 4.44E-16 1.786367528 p.(I244R) 0.418234561 1.04E-13 2.573426555 p.(I244N) 1.262387081 0 2.886628882 p.(I244D) 1.233438289 8.88E-16 1.779730526 p.(I244C) 0.390706114 8.75E-25 0.778941438 p.(I244Q) 0.708478221 0 1.042093352 p.(I244E) 0.644408809 1.44E-18 3.334781745 p.(I244G) 0.379194372 1.39E-16 2.035111526 p.(I244H) 0.809879376 0 2.486823229 p.(I244I) 0.383530387 0 1.115021385 p.(I244L) 0.414127407 8.69E-10 0.224029996 p.(I244K) 1.530794718 0 4.905614138 p.(I244M) 0.238978837 6.80E-31 0.771775001 p.(I244F) 0.349652176 1.33E-31 1.095603993 p.(I244P) 0.41045447 1.12E-44 3.185144725 p.(I244S) 0.473954843 1.18E-07 2.513138117 p.(I244T) 0.305813676 0 0.368547372 p.(I244W) 0.3889893 3.49E-41 0.619547083 p.(I244Y) 0.308603678 3.68E-08 1.256103132 p.(I244V) 0.256901555 4.84E-22 1.122511241 p.(L201A) 0.567517393 4.33E-15 1.02183219 p.(L201R) 1.233459497 5.83E-06 -2.693294296 p.(L201N) 0.526550731 5.35E-18 0.570109114 p.(L201D) 0.807785601 2.77E-57 -0.079894418 p.(L201C) 0.297938773 2.19E-14 0.975282455 p.(L201Q) 0.655965498 6.49E-14 0.084226785 p.(L201E) 0.644997361 2.44E-46 -0.199214836 p.(L201G) 0.295068179 7.01E-53 0.944742735 p.(L201H) 0.306370969 2.25E-66 0.016642998 p.(L201I) 0.077001299 4.49E-89 1.018673146 p.(L201L) 0.135135889 0 -0.342403922 p.(L201K) 0.944245776 1.12E-34 -2.922682873 p.(L201M) 0.182614545 1.60E-75 0.984956623 p.(L201F) 0.131730055 1.81E-36 -0.906567115 p.(L201P) 0.499137075 2.37E-62 -0.51316976 p.(L201S) 0.697187827 7.40E-74 0.138641979 p.(L201T) 0.038486786 3.12E-100 0.642930098 p.(L201W) 0.272143575 1.15E-14 0.318875085 p.(L201Y) 0.567735746 1.60E-78 -0.295537812 p.(L201V) 0.35687432 9.97E-12 0.08761096 p.(L216A) 0.851586161 1.38E-08 -3.302065134 p.(L216R) 0.78131871 5.72E-09 -3.67289443 p.(L216N) 0.590633334 8.11E-27 -4.293216495 p.(L216D) 1.069023006 4.44E-16 -3.673882607 p.(L216C) 0.58367375 7.78E-46 -4.099966553 p.(L216Q) 0.817469674 2.17E-89 -2.342442612 p.(L216E) 0.73426572 1.16E-06 -3.160715026 p.(L216G) 1.607449683 0 -4.588129041 p.(L216H) 0.966978992 1.07E-09 0.09644336 p.(L216I) 1.159392485 9.65E-26 -1.69157664 p.(L216L) 0.164934363 2.10E-10 -0.604489737 p.(L216K) 0.758718264 6.20E-26 -2.654846048 p.(L216M) 0.198212798 2.91E-07 -0.259522791 p.(L216F) 0.772215734 4.95E-91 0.233577927 p.(L216P) 1.102277485 3.62E-15 0.458128498 p.(L216S) 0.915974748 2.22E-16 -2.570405849 p.(L216T) 0.728905923 1.31E-67 -2.893841387 p.(L216W) 0.901836128 4.93E-09 -3.057535509 p.(L216Y) 0.496779694 6.12E-11 0.151283739 p.(L216V) 1.062403042 1.54E-40 -2.73558094 p.(L218A) 0.882867155 1.46E-75 -0.393749963 p.(L218R) 0.566379692 1.81E-42 -3.791823528 p.(L218N) 0.620222512 0.000215965 -4.712782241 p.(L218D) 1.265792376 5.80E-13 -3.545396104 p.(L218C) 0.379630971 4.23E-63 1.438091294 p.(L218Q) 1.081989612 0 -3.083345069 p.(L218E) 0.826281208 0 -3.295829629 p.(L218G) 1.170372206 4.44E-16 -3.027637178 p.(L218H) 0.711941827 0.000122409 -3.46631393 p.(L218I) 0.085262819 4.28E-09 -0.681354768 p.(L218L) 0.789952665 1.35E-34 0.240648988 p.(L218K) 0.704242967 1.60E-33 -4.152864902 p.(L218M) 0.269262472 5.05E-35 1.048248335 p.(L218F) 0.28013383 8.90E-15 -1.118930867 p.(L218P) 0.3902486 1.67E-16 -2.406471776 p.(L218S) 0.736601186 1.45E-34 -3.819085027 p.(L218T) 1.256717035 1.94E-24 -1.844608144 p.(L218W) 0.784431777 6.32E-21 -2.742441558 p.(L218Y) 0.741480635 5.44E-07 -3.339356039 p.(L218V) 0.651550404 3.92E-53 0.368349171 p.(L225A) 0.346553813 4.39E-38 1.084269358 p.(L225R) 0.515206849 1.92E-10 0.696959063 p.(L225N) 0.612310124 4.48E-64 0.552201743 p.(L225D) 0.446469922 6.77E-07 0.672072917 p.(L225C) 0.540767417 0.001699424 0.880191417 p.(L225Q) 0.569937101 3.30E-07 0.841370077 p.(L225E) 0.468773732 2.59E-30 0.343866664 p.(L225G) 0.599212821 4.68E-43 0.671719414 p.(L225H) 0.084882093 1.58E-26 0.906108542 p.(L225I) 0.60960464 1.11E-16 1.620589906 p.(L225L) 0.24093217 1.48E-63 0.953330613 p.(L225K) 0.437726238 1.25E-79 1.740092828 p.(L225M) 0.175419367 0 -0.295583306 p.(L225F) 0.388523449 4.22E-13 2.068979457 p.(L225P) 0.088090591 0 -0.479585455 p.(L225S) 1.530145588 0 1.60562901 p.(L225T) 0.604101841 0 1.572772478 p.(L225W) 0.373010381 3.44E-06 1.540678685 p.(L225Y) 0.419623794 2.60E-19 0.659215633 p.(L225V) 0.367626347 2.06E-53 1.285481576 p.(L230A) 0.085686602 7.78E-43 0.749080646 p.(L230R) 1.003590442 6.06E-34 -0.023332962 p.(L230N) 0.373568411 9.13E-62 0.871755274 p.(L230D) 0.798344825 7.63E-40 -0.218879176 p.(L230C) 0.454824427 4.50E-56 0.272652522 p.(L230Q) 0.412294899 8.63E-21 0.55378205 p.(L230E) 1.450885167 3.71E-34 -0.564808528 p.(L230G) 0.386415091 7.93E-37 0.569928309 p.(L230H) 0.485890517 5.42E-31 0.568773055 p.(L230I) 0.484586035 3.16E-53 1.070920608 p.(L230L) 0.28271611 0 0.178954869 p.(L230K) 0.888892955 3.42E-65 -0.707290041 p.(L230M) 0.680757703 3.80E-43 -0.015718926 p.(L230F) 0.268065011 8.33E-17 -0.684089366 p.(L230P) 0.701213712 0 0.361936917 p.(L230S) 0.494269521 3.94E-07 0.736577926 p.(L230T) 0.693081329 3.16E-33 0.423189626 p.(L230W) 0.515216803 3.80E-50 0.191249933 p.(L230Y) 0.907425829 1.61E-61 0.108069533 p.(L230V) 0.215402895 0.001651732 0.568883473 p.(L239A) 0.732849187 2.88E-41 -2.898147762 p.(L239R) 0.431562707 4.15E-14 -4.032860649 p.(L239N) 1.71074106 1.78E-15 -3.413036122 p.(L239D) 0.58540728 1.51E-35 -4.514176037 p.(L239C) 0.749092368 4.93E-55 0.371495534 p.(L239Q) 1.142486783 1.48E-51 -2.353270309 p.(L239E) 0.884554683 0 -4.442145085 p.(L239G) 0.620726006 1.65E-21 -4.335573153 p.(L239H) 0.49622466 2.40E-57 -1.16950478 p.(L239I) 0.390513589 4.29E-09 1.542802214 p.(L239L) 0.111893652 1.32E-36 -0.555386073 p.(L239K) 0.932146575 2.97E-07 -2.94130104 p.(L239M) 0.140070914 4.02E-11 0.006470469 p.(L239F) 0.413398657 9.25E-40 1.060465367 p.(L239P) 0.279328928 2.33E-70 -2.706292296 p.(L239S) 0.83218746 1.08E-14 -2.049139302 p.(L239T) 0.471761118 2.55E-09 -3.566560058 p.(L239W) 0.557962693 1.08E-103 0.195939135 p.(L239Y) 0.098060364 3.23E-13 0.535171104 p.(L239V) 0.298509675 5.31E-05 0.991210775 p.(L240A) 0.723442224 2.03E-64 -0.561001693 p.(L240R) 0.531870857 1.94E-48 -0.855020758 p.(L240N) 0.528657018 6.24E-89 -0.610401396 p.(L240D) 0.606690266 0.000103794 -4.215721034 p.(L240C) 0.353317603 1.14E-14 0.74663212 p.(L240Q) 0.736553402 2.02E-97 -0.493629981 p.(L240E) 1.222752424 0 -4.643984504 p.(L240G) 1.976372583 5.33E-15 -4.029020611 p.(L240H) 0.251823277 5.07E-100 0.600053013 p.(L240I) 0.536805634 7.26E-46 0.84293973 p.(L240L) 0.129475198 4.00E-13 -0.35589027 p.(L240K) 1.76884191 0 -2.052600279 p.(L240M) 0.293585368 0 -0.390657957 p.(L240F) 0.383473616 0 0.165014175 p.(L240P) 0.803973644 5.87E-08 -3.39982533 p.(L240S) 0.982212627 1.23E-71 -0.859915002 p.(L240T) 0.582799828 5.32E-31 0.240456551 p.(L240W) 0.356747513 4.34E-29 0.39131408 p.(L240Y) 0.860726607 3.41E-48 0.129603339 p.(L240V) 0.531241694 1.84E-34 0.553299219 p.(K215A) 0.78284252 5.01E-14 0.676707295 p.(K215R) 0.136663298 4.66E-07 -0.272785194 p.(K215N) 0.252243424 2.78E-17 -0.601197496 p.(K215D) 0.655970689 3.99E-26 -2.467018621 p.(K215C) 0.555013723 6.15E-08 1.492092889 p.(K215Q) 0.861028732 1.64E-16 0.995726205 p.(K215E) 0.190316823 2.04E-30 -0.85583749 p.(K215G) 0.817463492 5.73E-75 0.208718244 p.(K215H) 0.531174112 3.68E-10 0.894845386 p.(K215I) 0.636360438 2.68E-64 0.36723272 p.(K215L) 0.54465135 9.59E-05 0.901624211 p.(K215M) 0.273114642 7.51E-19 1.067245116 p.(K215F) 0.8870538 7.32E-31 -0.791440018 p.(K215P) 0.45650381 0.001859044 -3.64497458 p.(K215S) 0.993185305 0.009947405 -1.030621166 p.(K215T) 0.440323672 3.14E-10 0.751608217 p.(K215W) 1.669902465 3.03E-66 -0.950412145 p.(K215Y) 0.754379632 3.47E-26 -0.484795623 p.(K215V) 0.248780192 5.23E-12 1.570721643 p.(K227A) 0.759359165 1.12E-35 0.111783668 p.(K227R) 0.061215487 2.31E-07 -0.034240359 p.(K227N) 0.328370153 1.56E-12 -0.572618563 p.(K227D) 0.484923193 0.001539641 0.27770759 p.(K227C) 0.518685356 1.26E-90 -0.033194464 p.(K227Q) 0.32771071 3.10E-94 -0.072249417 p.(K227E) 0.230834132 0 -0.32273316 p.(K227G) 0.469311305 2.42E-15 0.358573626 p.(K227H) 0.348023062 7.76E-21 0.143593985 p.(K227I) 0.439281858 3.64E-82 0.551404467 p.(K227L) 0.470974047 1.71E-50 0.159705862 p.(K227K) 0.128801786 0 0.033095017 p.(K227M) 0.279285872 5.42E-07 0.183945689 p.(K227F) 0.603387755 0 0.616970416 p.(K227P) 0.318747469 7.56E-23 -1.432671125 p.(K227S) 0.603862062 7.03E-65 0.092686521 p.(K227T) 0.21423734 3.63E-71 0.748210599 p.(K227W) 0.372285978 3.71E-34 0.084094087 p.(K227Y) 0.457765224 1.87E-20 0.520979111 p.(K227V) 0.737250202 2.22E-16 0.789274057 p.(K241A) 0.79321708 8.81E-45 -0.379286054 p.(K241R) 0.337075845 2.97E-27 0.767241815 p.(K241N) 0.449569929 6.52E-86 0.703330354 p.(K241D) 0.46730251 2.79E-59 0.062074738 p.(K241C) 0.509133635 1.80E-59 0.173552538 p.(K241Q) 0.349589914 5.91E-09 0.614194194 p.(K241E) 0.702852373 1.27E-36 -0.094549878 p.(K241G) 0.61931826 4.18E-44 0.475861966 p.(K241H) 0.296859219 5.11E-08 0.491524802 p.(K241I) 0.359333962 2.25E-67 0.133097609 p.(K241L) 0.759942154 2.21E-12 -0.416389485 p.(K241K) 0.215585381 1.42E-44 0.146072741 p.(K241M) 0.415291246 7.71E-42 -0.462499208 p.(K241F) 0.476702783 3.95E-25 0.666853754 p.(K241P) 0.627352865 1.77E-70 -1.419802218 p.(K241S) 0.412837325 3.71E-07 0.403362855 p.(K241T) 0.637393043 1.62E-35 -0.334855667 p.(K241W) 0.186297815 1.26E-32 0.481289944 p.(K241Y) 1.036787478 7.90E-53 0.066632842 p.(K241V) 0.508792856 1.96E-43 0.108969707 p.(M211A) 0.39886728 0.000217792 1.283210985 p.(M211R) 1.364570953 4.73E-45 -1.86525481 p.(M211N) 1.278672965 4.12E-07 -1.704078909 p.(M211D) 0.837212155 2.80E-51 -1.22834961 p.(M211C) 0.377614186 2.78E-17 1.483316945 p.(M211Q) 0.292725944 2.86E-13 2.099573556 p.(M211E) 0.364907651 1.04E-11 2.948646132 p.(M211G) 0.836419715 5.52E-79 -0.660456078 p.(M211H) 0.300423256 1.15E-12 1.53815309 p.(M211I) 0.129010392 3.28E-08 -0.103845885 p.(M211L) 0.627859904 3.92E-86 0.344409043 p.(M211K) 1.162346508 1.53E-67 0.178520924 p.(M211F) 0.568800387 0.000509989 -0.103202529 p.(M211P) 0.499191175 0 1.976278278 p.(M211S) 0.39199281 1.27E-20 0.868558138 p.(M211T) 0.719869833 7.92E-82 0.919884611 p.(M211W) 0.950890377 1.47E-41 -0.578828371 p.(M211Y) 0.507546534 1.32E-152 0.373963843 p.(M211V) 0.380080222 5.10E-27 1.034655476 p.(M219A) 0.501872155 8.38E-26 -0.598464431 p.(M219R) 1.310636863 0 -5.298782521 p.(M219N) 0.896198022 3.42E-70 -3.059488624 p.(M219D) 0.344908342 7.79E-73 -3.739895343 p.(M219C) 0.673673221 5.24E-45 0.674317563 p.(M219Q) 0.276600915 1.74E-55 0.944348405 p.(M219E) 0.421624752 1.00E-08 1.44538523 p.(M219G) 1.01736668 9.40E-19 -2.602185442 p.(M219H) 1.019879765 3.77E-21 -0.665259807 p.(M219I) 0.420493975 2.21E-44 -1.281154916 p.(M219L) 0.69593844 7.48E-23 0.505616588 p.(M219K) 0.506292779 3.51E-08 -3.28626727 p.(M219F) 0.725187479 0 0.168560849 p.(M219P) 0.719957621 3.24E-38 -3.441590618 p.(M219S) 0.227924192 9.65E-37 0.328182192 p.(M219T) 0.060561456 1.97E-18 -1.100321254 p.(M219W) 1.667631062 0 -0.718410307 p.(M219Y) 1.089754738 1.98E-07 -0.743660446 p.(M219V) 0.342182472 3.19E-56 -2.184999736 p.(F203A) 1.074935968 4.58E-23 -1.055669487 p.(F203R) 0.70188774 6.13E-07 -2.779370585 p.(F203N) 0.707242113 0.000885461 -3.247907612 p.(F203D) 1.042263553 0 -4.023922012 p.(F203C) 0.522042621 1.17E-08 -0.016443451 p.(F203Q) 0.832450825 3.50E-09 -2.125008137 p.(F203E) 1.232996943 0 -3.397523074 p.(F203G) 0.319630479 1.40E-44 -3.831898452 p.(F203H) 0.729210637 8.82E-51 -0.422909481 p.(F203I) 0.940611352 2.02E-68 -0.221818861 p.(F203L) 0.221364813 6.04E-12 -0.499405756 p.(F203K) 0.613523274 7.07E-11 -3.585176473 p.(F203M) 0.55671543 4.64E-69 0.250828071 p.(F203P) 1.11267714 1.71E-13 -2.411184978 p.(F203S) 0.951182948 0.001045906 -2.846365192 p.(F203T) 0.821446196 2.98E-93 -1.393344225 p.(F203W) 0.379847024 0.000104358 0.29866634 p.(F203Y) 0.796342449 5.06E-79 0.169251366 p.(F203V) 1.010115686 6.88E-15 -0.48171462 p.(S204A) 0.307856666 2.37E-51 0.517046141 p.(S204R) 0.600421531 1.29E-19 -3.699127324 p.(S204N) 0.864842004 8.34E-12 -2.102911435 p.(S204D) 0.673556612 5.31E-21 -4.038423815 p.(S204C) 0.299952894 6.22E-77 0.210426002 p.(S204Q) 0.344975728 0.000234471 -4.206570464 p.(S204E) 0.806824703 2.45E-05 -4.202520796 p.(S204G) 0.519725606 6.71E-77 -0.53863473 p.(S204H) 1.116547257 1.62E-62 -2.21604646 p.(S204I) 1.466510417 8.88E-16 -4.332277937 p.(S204L) 0.638100979 5.85E-63 -3.067726069 p.(S204K) 1.237616681 0 -4.345721739 p.(S204M) 1.811291995 0 -4.285245343 p.(S204F) 0.827499944 9.62E-85 -3.280800191 p.(S204P) 1.042416921 4.56E-53 0.196499851 p.(S204S) 0.0264559 2.38E-32 0.193810169 p.(S204T) 0.590970584 1.59E-58 0.28925691 p.(S204W) 0.545886704 8.53E-15 -3.952520731 p.(S204Y) 0.634235408 1.95E-16 -4.133986828 p.(S204V) 1.090481108 4.05E-30 -2.528555483 p.(S228A) 0.558142689 0 1.240218785 p.(S228R) 0.52229997 4.34E-09 1.377054822 p.(S228N) 0.572578211 2.98E-74 0.279512423 p.(S228D) 0.301497424 6.00E-48 0.774125792 p.(S228C) 0.291866756 0.000111301 0.959844146 p.(S228Q) 0.903225659 0 1.442878532 p.(S228E) 0.372993075 8.44E-48 -0.083523865 p.(S228G) 0.727006744 1.39E-21 0.092927048 p.(S228H) 0.407377885 0.001346103 0.553633314 p.(S228I) 0.457595699 1.69E-31 1.382621008 p.(S228L) 0.327261652 9.79E-05 0.22767213 p.(S228K) 0.650234094 0 1.039678351 p.(S228M) 0.978405345 0 1.588656982 p.(S228F) 0.160988348 0 -0.425457427 p.(S228P) 0.134314051 9.98E-05 -0.562661138 p.(S228S) 0.375029759 0 0.346182709 p.(S228T) 0.636695478 2.22E-16 1.597521714 p.(S228W) 0.120422107 2.43E-61 1.215052962 p.(S228Y) 0.68351456 2.22E-16 1.802635683 p.(S228V) 0.912576859 0 1.160289536 p.(S242A) 0.766578444 4.44E-16 1.026285359 p.(S242R) 0.21967242 3.73E-85 0.258637156 p.(S242N) 0.579261992 0 1.259499014 p.(S242D) 0.486821559 4.63E-10 1.259756169 p.(S242C) 0.267345699 3.16E-41 0.90814167 p.(S242Q) 0.461898447 8.56E-38 1.330811327 p.(S242E) 0.370951863 5.22E-21 1.089245867 p.(S242G) 0.242581357 6.74E-08 1.628032826 p.(S242H) 0.321846322 2.19E-35 1.048062529 p.(S242I) 0.394668522 1.42E-05 0.215131398 p.(S242L) 0.904978061 2.22E-16 1.735943976 p.(S242K) 0.690929946 0 2.336589774 p.(S242M) 0.251806324 3.44E-145 2.439385987 p.(S242F) 0.291441076 1.66E-07 1.917368337 p.(S242P) 0.488084744 1.30E-18 0.72464736 p.(S242S) 0.154993479 1.39E-16 0.399364389 p.(S242T) 0.432138987 0 1.473354271 p.(S242W) 0.18528411 1.77E-12 1.223009876 p.(S242Y) 0.202160865 5.19E-78 0.472164827 p.(S242V) 0.32277544 1.15E-16 1.436003788 p.(T200A) 0.827306092 0 1.345370191 p.(T200R) 0.487041816 0 1.15900066 p.(T200N) 0.217015759 1.81E-12 0.6505806 p.(T200D) 0.441346361 1.04E-13 -0.016323474 p.(T200C) 0.784981105 4.44E-16 1.513090702 p.(T200Q) 0.335961321 0 -0.142143193 p.(T200E) 0.325945835 0.001567233 1.358521078 p.(T200G) 0.370124424 3.61E-16 0.390839406 p.(T200H) 0.532917379 9.89E-10 1.626236396 p.(T200I) 0.340991309 7.22E-19 0.032820428 p.(T200L) 0.329106314 1.46E-53 0.575045297 p.(T200K) 0.952662447 0 1.805637757 p.(T200M) 0.391755537 1.11E-16 -0.161735575 p.(T200F) 0.509984628 2.18E-45 -0.18919469 p.(T200P) 0.739674465 0 1.880606178 p.(T200S) 0.356842274 0 1.52271317 p.(T200T) 0.21708308 1.97E-07 0.521076071 p.(T200W) 0.485485644 7.85E-45 0.35006873 p.(T200Y) 0.777401888 2.22E-16 0.866937797 p.(T200V) 0.860704671 1.01E-59 -0.087759331 p.(W220A) 0.401299134 2.03E-31 0.534116908 p.(W220R) 1.114867274 0 -4.07383705 p.(W220N) 0.865361575 0.008279811 0.471206111 p.(W220D) 0.552633852 2.72E-16 -4.282702335 p.(W220C) 0.271778114 1.36E-35 -0.00953623 p.(W220Q) 0.603777825 1.54E-41 -1.194662705 p.(W220E) 0.623459167 3.03E-31 -3.924606779 p.(W220G) 0.806082446 0 -1.389355611 p.(W220H) 1.055312357 2.05E-77 -1.618472505 p.(W220I) 0.698333589 2.74E-110 -0.002211376 p.(W220L) 0.09590275 6.23E-94 -0.426703264 p.(W220K) 0.731772874 7.43E-39 -3.694921955 p.(W220M) 0.219221676 1.78E-26 -0.44004628 p.(W220F) 0.725704557 5.39E-64 0.218263831 p.(W220P) 0.776066545 1.72E-47 -3.473459236 p.(W220S) 0.408913836 0.000254626 1.440741681 p.(W220T) 0.670838883 9.58E-09 0.306605533 p.(W220Y) 0.462638626 1.44E-21 0.105785854 p.(W220V) 0.5061948 4.01E-08 0.312847983 p.(V202A) 0.416875705 1.67E-16 0.533945124 p.(V202R) 0.408802783 0.00101377 1.08451024 p.(V202N) 0.251266625 6.45E-58 0.050603738 p.(V202D) 0.6504883 2.22E-16 0.314134247 p.(V202C) 0.349622166 1.00E-23 0.741556923 p.(V202Q) 0.337669167 0.000321347 0.829521772 p.(V202E) 0.622585635 0 1.421236743 p.(V202G) 1.093041449 7.25E-38 -0.062606855 p.(V202H) 0.54273573 1.77E-41 0.434223285 p.(V202I) 0.185674644 2.46E-82 -0.089424116 p.(V202L) 0.373995448 1.12E-06 0.41435293 p.(V202K) 0.517526034 1.64E-12 1.68638466 p.(V202M) 0.644233434 0 0.880674635 p.(V202F) 0.354559223 0 -0.206311556 p.(V202P) 0.652666532 7.18E-11 -0.650890555 p.(V202S) 0.371206199 1.02E-20 0.300257846 p.(V202T) 0.157255347 1.79E-54 1.14590399 p.(V202W) 0.726296458 1.09E-94 -0.054611414 p.(V202Y) 0.664688518 0 0.706389213 p.(V208A) 0.982549352 0.005158304 -0.716127129 p.(V208R) 0.628811465 5.20E-33 -3.501581954 p.(V208N) 0.386538632 2.15E-34 -4.009160741 p.(V208D) 0.780968654 0 -4.601980073 p.(V208C) 0.522450162 4.10E-43 0.929118547 p.(V208Q) 0.787029351 5.95E-59 -2.175132629 p.(V208E) 0.59018603 3.15E-54 -3.985044497 p.(V208G) 1.179931688 0 -3.917686817 p.(V208H) 1.285310473 8.88E-16 -5.487050707 p.(V208I) 0.361611108 0.000164585 0.108961938 p.(V208L) 0.367588755 1.28E-09 0.443667229 p.(V208K) 0.691467478 1.89E-13 -4.192988153 p.(V208M) 0.28987326 1.27E-13 -2.597659007 p.(V208F) 0.801617772 0 -3.390531344 p.(V208P) 0.572952933 6.04E-07 -4.071778361 p.(V208S) 0.858948734 1.13E-08 -4.195716051 p.(V208T) 0.687079094 8.90E-87 0.394439232 p.(V208W) 1.370251307 0 -3.362838563 p.(V208Y) 0.454234026 3.42E-05 -3.256076958 p.(V208V) 0.075153951 9.91E-25 0.254455188 p.(V222A) 0.262645575 5.55E-17 -0.491913767 p.(V222R) 0.921739351 1.53E-14 -3.806080932 p.(V222N) 0.495832914 1.02E-06 -4.094038907 p.(V222D) 0.866336682 1.11E-15 -3.434472194 p.(V222C) 0.318034633 8.28E-08 1.303309115 p.(V222Q) 0.642160309 1.12E-15 -2.570574218 p.(V222E) 0.558617873 6.94E-17 -4.453230467 p.(V222G) 0.902806352 0.017069901 -2.25990797 p.(V222H) 0.676848915 2.21E-19 -3.512483248 p.(V222I) 0.576523763 5.31E-69 0.383286768 p.(V222L) 0.669284935 4.76E-25 0.551008349 p.(V222K) 1.084713014 0 -4.020921751 p.(V222M) 0.226699781 0 -0.01729029 p.(V222F) 0.751366972 9.02E-69 -0.075351111 p.(V222P) 0.657584607 4.10E-22 -3.668791257 p.(V222S) 0.456823129 1.26E-40 -2.741545561 p.(V222T) 1.097019124 5.01E-34 -2.074308724 p.(V222W) 0.699558775 1.44E-11 -1.699758423 p.(V222Y) 1.100492098 2.82E-73 -2.361101376 p.(V222V) 0.483068533 1.11E-16 0.801549714 p.(V231A) 0.778689553 0 1.21037638 p.(V231R) 0.488908661 0 0.463454546 p.(V231N) 0.803457603 7.93E-108 -0.620786261 p.(V231D) 0.799304892 3.53E-53 0.231133003 p.(V231C) 0.470583514 1.26E-07 1.170565792 p.(V231Q) 0.491263035 3.33E-16 0.231743802 p.(V231E) 0.328975959 5.70E-82 0.006461355 p.(V231G) 0.196128592 4.50E-121 -0.491527266 p.(V231H) 0.65757578 0 1.018039854 p.(V231I) 0.479636941 5.85E-53 0.329614179 p.(V231L) 0.310124491 7.35E-05 1.471405468 p.(V231K) 0.422958649 7.24E-66 0.634772491 p.(V231M) 0.377435207 3.88E-09 0.522056629 p.(V231F) 0.822632713 2.94E-13 0.89977775 p.(V231P) 0.794725232 1.91E-10 -0.497093888 p.(V231S) 1.186794368 0 0.753480844 p.(V231T) 0.533350698 9.53E-14 0.645456416 p.(V231W) 0.409278423 1.28E-07 1.343855985 p.(V231Y) 0.375099514 3.90E-21 0.763003864 p.(V231V) 0.079808049 4.10E-13 -0.04562461 p.(V235A) 0.451649124 6.75E-24 0.388350094 p.(V235R) 0.702931369 0.000414327 -3.060533834 p.(V235N) 0.626939715 1.37E-27 -3.805600767 p.(V235D) 0.619341212 5.08E-62 -2.445815266 p.(V235C) 0.438120267 4.29E-20 0.853722785 p.(V235Q) 0.614685086 2.35E-18 -4.333711175 p.(V235E) 0.475837435 2.22E-08 -3.842991659 p.(V235G) 0.827661412 4.49E-39 -1.477837217 p.(V235H) 0.97647146 9.69E-73 -1.905526724 p.(V235I) 0.192994013 6.31E-76 0.149962742 p.(V235L) 0.789659973 7.72E-104 -0.441822897 p.(V235K) 0.594554202 4.27E-07 -3.746876655 p.(V235M) 0.619600507 2.35E-38 -0.236389582 p.(V235F) 0.600512406 3.48E-54 0.079767762 p.(V235P) 0.725824212 4.22E-20 0.392578041 p.(V235S) 0.676126268 2.85E-28 -0.330154751 p.(V235T) 1.008196555 2.24E-26 -0.239377147 p.(V235W) 0.283402297 1.54E-12 -1.36104801 p.(V235Y) 0.531931298 1.69E-05 -3.600850352 p.(V235V) 0.123539315 1.35E-18 -0.207133708 p.(R268A) 0.412917311 9.28E-58 0.165039989 p.(R268N) 0.305556622 1.94E-20 0.295843079 p.(R268D) 0.417474803 0.001006864 0.047481704 p.(R268C) 0.45409921 8.44E-07 0.63063433 p.(R268Q) 0.363302926 8.20E-79 0.876830692 p.(R268E) 0.44299671 0 1.319836742 p.(R268G) 0.162095225 2.39E-52 -0.405144201 p.(R268H) 0.245522421 2.08E-29 1.636928717 p.(R268I) 0.910296005 5.98E-10 -0.366136937 p.(R268L) 1.463106085 1.28E-35 0.005687776 p.(R268K) 0.40708362 1.29E-31 0.648569457 p.(R268M) 0.22395513 0.000791646 -0.647293585 p.(R268F) 0.584092741 4.49E-40 -0.104470089 p.(R268P) 0.624145318 9.42E-17 -0.321064021 p.(R268S) 0.424587534 5.30E-41 0.793016784 p.(R268T) 0.394850244 1.09E-24 0.908770866 p.(R268W) 0.238823555 4.45E-44 0.546028539 p.(R268Y) 0.398128813 1.01E-38 0.530609297 p.(R268V) 0.733785514 8.10E-43 -0.182231108 p.(N259A) 0.503741804 1.16E-07 0.094535845 p.(N259R) 0.506618939 2.76E-16 0.752187675 p.(N259D) 0.153505766 0 0.376172944 p.(N259C) 0.603865392 8.68E-87 0.522040177 p.(N259Q) 0.428861083 7.24E-05 1.460017583 p.(N259E) 0.380338443 3.69E-29 0.613910139 p.(N259G) 0.303545358 3.41E-14 0.491267924 p.(N259H) 0.218123379 7.73E-84 0.479491652 p.(N259I) 0.979682087 7.51E-32 -0.09338113 p.(N259L) 0.766555132 5.68E-85 0.154575737 p.(N259K) 0.696974317 8.72E-50 -0.077011836 p.(N259M) 0.463361098 1.26E-41 0.85262615 p.(N259F) 0.360186658 3.01E-65 -0.289104928 p.(N259P) 0.431897348 2.34E-58 0.484563391 p.(N259S) 0.349230407 9.62E-28 0.901141261 p.(N259T) 0.355677059 1.27E-13 0.669644636 p.(N259W) 1.343948053 6.20E-43 -1.351561621 p.(N259Y) 0.943056196 5.43E-55 -0.121728729 p.(N259V) 0.864540745 3.29E-79 0.203050838 p.(D254A) 0.408193997 2.31E-28 1.00796415 p.(D254R) 0.413599882 5.02E-22 1.53541927 p.(D254N) 0.258544899 2.04E-05 0.608928816 p.(D254D) 0.137440303 7.02E-24 0.232426151 p.(D254C) 0.488164257 2.75E-86 0.400501725 p.(D254Q) 0.27112072 2.71E-10 1.32834028 p.(D254E) 0.306527264 3.27E-56 0.926673716 p.(D254G) 0.076476835 8.96E-24 0.141382215 p.(D254H) 0.779924914 7.68E-59 -0.294025192 p.(D254I) 0.980536033 8.94E-33 0.456384829 p.(D254L) 0.741630625 3.19E-36 0.475547398 p.(D254K) 0.074040855 6.11E-61 0.838399151 p.(D254M) 0.593491166 1.53E-16 0.600751551 p.(D254F) 0.900446572 2.99E-06 -0.078884649 p.(D254P) 0.281431162 4.93E-85 0.279074441 p.(D254S) 0.527655259 0 -0.028881365 p.(D254T) 0.289073111 5.90E-65 -0.516185421 p.(D254W) 0.749658931 9.51E-133 0.101231871 p.(D254Y) 0.116045303 1.90E-11 -0.563144109 p.(D254V) 0.563774533 1.72E-42 0.4452422 p.(D257A) 0.753450177 0.001807525 0.161586458 p.(D257R) 0.508880331 1.68E-73 -0.203213413 p.(D257N) 0.547050793 1.39E-47 0.628845042 p.(D257C) 0.383399776 5.34E-55 0.76016636 p.(D257Q) 0.730393251 6.76E-15 0.514306533 p.(D257E) 0.538463604 6.06E-07 1.056807754 p.(D257G) 0.807200183 3.59E-78 0.314641715 p.(D257H) 0.538444395 1.25E-12 -0.014631567 p.(D257I) 1.118288847 5.90E-80 -0.645710091 p.(D257L) 0.973656678 1.39E-62 -0.673780023 p.(D257K) 0.620171329 2.85E-09 -0.117245506 p.(D257M) 1.307765653 7.64E-85 0.393624078 p.(D257F) 0.86297391 2.06E-126 -0.049316558 p.(D257P) 0.389327414 3.16E-41 0.782745218 p.(D257S) 0.64340848 0 0.558117385 p.(D257T) 0.356566737 0 -0.129274235 p.(D257W) 0.890456773 4.50E-54 0.307638205 p.(D257Y) 1.063867974 1.52E-42 0.074170444 p.(D257V) 1.320474317 7.43E-43 0.114609081 p.(D263A) 0.66700093 1.36E-56 -0.158787417 p.(D263R) 0.62975407 1.09E-50 0.449163148 p.(D263N) 0.384746788 5.45E-25 0.567648606 p.(D263D) 0.248594253 2.36E-11 -0.144401656 p.(D263C) 0.154247797 1.05E-48 0.596918082 p.(D263Q) 0.476619607 5.96E-61 0.568071341 p.(D263E) 0.428338246 1.83E-35 0.376764985 p.(D263G) 0.611274023 8.76E-48 0.179535564 p.(D263H) 0.762845989 8.65E-11 -0.088468837 p.(D263I) 0.887900245 7.91E-47 0.038968946 p.(D263L) 0.903937407 7.89E-33 -0.322560508 p.(D263K) 0.122641903 6.60E-24 0.179969757 p.(D263M) 0.477424416 7.63E-39 0.46411004 p.(D263F) 0.72640331 2.36E-63 -0.431729903 p.(D263P) 0.42191857 2.35E-32 -0.123413971 p.(D263S) 0.303563876 1.05E-63 0.641162934 p.(D263T) 1.140129764 1.73E-13 -0.184575887 p.(D263W) 1.137693611 4.86E-51 0.097185139 p.(D263Y) 0.290463125 1.51E-24 -0.919501421 p.(D263V) 0.11933758 6.28E-45 0.691638005 p.(D267A) 0.825927325 1.82E-78 -0.345271307 p.(D267R) 0.680164863 3.17E-56 0.01643353 p.(D267N) 0.167080812 3.00E-10 0.284569033 p.(D267C) 1.094700703 9.02E-82 -0.400719752 p.(D267Q) 0.607011345 1.11E-16 1.117821755 p.(D267E) 0.309619927 8.33E-17 -0.501670133 p.(D267G) 0.607158683 9.25E-24 -0.059437663 p.(D267H) 0.443233966 1.67E-65 -0.123017109 p.(D267I) 1.446455033 2.48E-21 -1.45047976 p.(D267L) 0.824442806 8.08E-43 -0.961462881 p.(D267K) 0.480513793 7.84E-16 -0.092860864 p.(D267M) 1.296762834 9.39E-44 -0.029678534 p.(D267F) 1.143478448 8.28E-122 0.106416307 p.(D267P) 0.597076422 1.01E-43 -0.177070359 p.(D267S) 0.357565066 9.27E-80 0.545794139 p.(D267T) 0.675769816 4.31E-42 0.056271284 p.(D267W) 1.212401471 1.63E-48 -0.039996409 p.(D267Y) 0.443769625 6.61E-26 -1.006245459 p.(D267V) 1.037916989 9.94E-15 -0.762432052 p.(D282A) 0.55371087 6.97E-38 0.538013344 p.(D282R) 0.122407394 7.04E-09 1.541422304 p.(D282N) 0.487230002 7.53E-08 1.770956548 p.(D282C) 0.653853569 2.71E-81 0.28512408 p.(D282Q) 0.160538254 1.94E-65 -0.330133928 p.(D282E) 0.509325739 2.40E-89 0.251574431 p.(D282G) 0.538360003 1.24E-12 2.500674322 p.(D282H) 1.010783056 3.63E-93 -0.10486366 p.(D282I) 1.053142552 5.70E-54 -0.165814144 p.(D282L) 0.444826761 6.26E-17 0.546113065 p.(D282K) 0.430509155 1.11E-16 0.545488443 p.(D282M) 0.740224149 1.39E-30 0.383242668 p.(D282F) 1.460305086 1.38E-41 -1.485425836 p.(D282P) 0.666550436 1.16E-21 -3.639473495 p.(D282S) 0.444221038 3.58E-55 1.569367988 p.(D282T) 0.248569359 1.07E-33 1.063692744 p.(D282W) 1.417544253 1.15E-50 -1.638804539 p.(D282Y) 1.078010811 1.37E-58 -2.511811199 p.(D282V) 0.525408864 3.82E-78 0.686496524 p.(D284A) 0.528594444 5.55E-17 1.599185786 p.(D284N) 0.39544375 8.55E-15 2.375559497 p.(D284D) 0.211507597 2.12E-15 0.588493122 p.(D284C) 0.538544808 1.11E-16 0.943381208 p.(D284Q) 0.478353612 0 1.257674105 p.(D284E) 0.251336248 0 1.655359414 p.(D284G) 0.081093464 1.27E-46 0.47799011 p.(D284H) 0.431790015 1.59E-23 2.384748696 p.(D284I) 0.344606083 9.87E-09 1.464015807 p.(D284L) 0.497636532 2.99E-70 1.01324452 p.(D284K) 0.464943848 5.55E-17 2.76110315 p.(D284M) 0.399053221 7.17E-33 1.287897502 p.(D284F) 0.5293852 5.79E-08 0.40531563 p.(D284P) 0.899250398 0.003056836 -0.102859999 p.(D284S) 0.37107491 2.22E-16 1.303839342 p.(D284W) 1.074692538 2.09E-24 0.747248684 p.(D284Y) 0.321681476 0.000366024 1.118715904 p.(D284V) 0.520501499 3.42E-67 1.1283517 p.(D289A) 0.577590419 3.62E-102 0.536677587 p.(D289R) 0.397401934 6.88E-21 -0.448450705 p.(D289N) 0.413342033 6.91E-78 -0.734201834 p.(D289C) 0.591315875 1.90E-32 0.111363361 p.(D289Q) 0.589824856 4.31E-11 1.018775809 p.(D289E) 0.283643636 1.67E-16 0.375735183 p.(D289G) 0.155723216 0 -0.528364808 p.(D289H) 0.315445375 1.56E-54 0.076853884 p.(D289I) 0.833184814 3.15E-112 0.018394491 p.(D289L) 0.272500931 2.08E-92 -0.07365534 p.(D289K) 0.466671416 4.31E-51 0.262639876 p.(D289M) 0.552291456 4.46E-14 0.223668032 p.(D289F) 0.946525199 1.04E-53 -0.574933357 p.(D289P) 0.407833255 3.55E-53 0.202294886 p.(D289S) 0.136018865 8.74E-34 0.945884581 p.(D289T) 0.487770693 1.81E-62 0.228544073 p.(D289W) 1.099286131 6.13E-11 -1.150096651 p.(D289Y) 0.259955978 1.50E-10 -0.983619121 p.(D289V) 0.52714365 1.64E-56 -0.078894292 p.(Q255A) 0.487076564 1.72E-51 -0.135591948 p.(Q255R) 0.627142237 4.44E-16 0.270925474 p.(Q255N) 0.714840865 0.006303178 0.537415213 p.(Q255D) 0.400053567 2.65E-05 -0.783899608 p.(Q255C) 0.657929525 3.21E-113 0.252908538 p.(Q255E) 0.018173528 8.63E-28 0.183527073 p.(Q255G) 0.23079326 3.73E-52 1.157686612 p.(Q255H) 0.119454048 2.35E-27 -0.42077912 p.(Q255I) 0.617026492 1.09E-36 0.378764598 p.(Q255L) 0.399246144 2.80E-75 0.850374818 p.(Q255K) 0.154637811 7.16E-52 -0.602298984 p.(Q255M) 0.544445687 1.23E-46 0.765482033 p.(Q255F) 0.604390772 2.06E-16 0.123503568 p.(Q255P) 0.335160081 2.87E-10 0.662470467 p.(Q255S) 0.360418068 4.51E-89 0.121327793 p.(Q255T) 0.511281093 5.63E-26 0.58571837 p.(Q255W) 0.427128469 1.39E-13 0.477198194 p.(Q255Y) 0.746162938 2.34E-67 0.264456907 p.(Q255V) 0.487535143 9.65E-13 1.177615196 p.(E247A) 0.216818819 4.28E-36 0.653863388 p.(E247R) 0.463486272 7.39E-42 -0.162658847 p.(E247N) 0.504700628 0 0.476632122 p.(E247D) 0.170458185 1.04E-75 0.467568239 p.(E247C) 0.20186601 8.55E-33 0.80007719 p.(E247Q) 0.266096424 2.13E-42 0.932465399 p.(E247G) 0.136271233 6.02E-20 -0.005198996 p.(E247H) 0.065999809 2.19E-62 1.136045507 p.(E247I) 0.749030424 9.00E-78 -0.468614676 p.(E247L) 0.729354248 2.67E-151 -0.504026138 p.(E247K) 0.242296709 2.28E-30 -0.178411176 p.(E247M) 0.27357281 2.10E-22 0.676859685 p.(E247F) 0.748588813 2.36E-93 -0.3009692 p.(E247P) 0.260933717 4.00E-05 0.976508453 p.(E247S) 0.289336632 3.83E-22 0.979590065 p.(E247T) 0.222911085 1.01E-41 0.010938669 p.(E247W) 0.819985888 6.47E-25 0.14892183 p.(E247Y) 0.586251209 2.75E-112 -0.034233514 p.(E247V) 0.434071792 2.60E-06 0.804757861 p.(E249A) 0.693098205 0 1.04326434 p.(E249R) 0.183288524 4.40E-17 0.430615452 p.(E249N) 0.663929887 0 0.936854864 p.(E249D) 0.371270207 5.66E-11 0.087296076 p.(E249C) 0.60739793 4.69E-70 0.724817129 p.(E249Q) 0.434949289 3.61E-161 0.121187778 p.(E249E) 0.172200641 1.12E-27 -0.198480425 p.(E249G) 0.268066634 4.03E-74 1.274847685 p.(E249H) 0.244676468 3.28E-26 0.95818479 p.(E249I) 0.834013566 7.17E-24 0.085415842 p.(E249L) 0.576546778 4.64E-65 0.651469993 p.(E249K) 0.634552504 0 3.048371627 p.(E249M) 0.351671203 1.85E-25 0.278806277 p.(E249F) 0.738342121 1.26E-63 -0.040240314 p.(E249P) 0.387934106 9.93E-06 0.277615981 p.(E249S) 0.27691667 2.23E-12 0.276833107 p.(E249T) 0.577011386 2.31E-19 1.025068839 p.(E249W) 0.999535328 1.33E-58 -0.397197268 p.(E249Y) 0.301049955 3.19E-44 -0.007518732 p.(E249V) 0.540935924 3.51E-26 1.025359054 p.(E280A) 0.589232112 6.19E-06 0.957352908 p.(E280R) 0.30580778 1.86E-54 1.393334556 p.(E280N) 0.171631488 1.82E-34 1.206164649 p.(E280D) 0.280932059 2.28E-53 0.450640509 p.(E280C) 0.208755094 3.98E-86 0.632846353 p.(E280Q) 0.208096627 2.25E-12 0.773764081 p.(E280E) 0.146274563 3.98E-24 -0.088481096 p.(E280G) 1.052872834 6.76E-08 -0.452123343 p.(E280H) 0.322636127 1.06E-34 0.666846545 p.(E280I) 0.210073562 5.49E-29 0.238788195 p.(E280L) 0.286148821 7.88E-27 0.906719375 p.(E280K) 0.514754087 8.11E-43 1.091904932 p.(E280M) 0.35460662 1.83E-32 1.331537824 p.(E280F) 0.207499975 2.71E-07 0.402772318 p.(E280P) 0.512890735 6.53E-21 0.555202402 p.(E280S) 0.57536846 6.39E-34 0.398000221 p.(E280T) 0.502778192 4.22E-58 1.12080928 p.(E280W) 0.028830657 4.23E-34 1.808014196 p.(E280Y) 0.358173177 1.57E-50 1.225574247 p.(E280V) 0.498100878 1.48E-28 0.478875757 p.(E283A) 0.485962628 0 1.290011527 p.(E283R) 0.639799441 0 1.617349976 p.(E283N) 0.465445423 3.98E-64 0.650684023 p.(E283D) 0.290821674 2.78E-17 -1.14480974 p.(E283C) 0.589278752 4.77E-63 0.674611403 p.(E283Q) 0.067406889 2.10E-79 0.380514349 p.(E283E) 0.081081526 2.79E-09 -0.570209896 p.(E283G) 0.404380286 4.50E-32 1.128285239 p.(E283H) 0.424941304 1.92E-21 1.19743439 p.(E283I) 0.45951657 9.83E-24 0.03888304 p.(E283L) 0.636393572 6.74E-51 -0.006480402 p.(E283K) 0.211216436 0.00080193 0.361215062 p.(E283M) 0.796601976 1.08E-49 0.112099934 p.(E283F) 1.055312629 1.96E-37 -0.9229387 p.(E283P) 0.437723738 5.33E-07 0.914715271 p.(E283S) 0.22413613 8.57E-12 0.073276815 p.(E283T) 0.245145155 8.29E-49 0.683424132 p.(E283W) 1.031758013 2.41E-44 -1.002076857 p.(E283Y) 0.503940826 0.000430113 -1.152120946 p.(E283V) 0.365016355 2.69E-68 0.784296656 p.(G248A) 0.603824796 1.88E-38 0.308039142 p.(G248R) 0.463232951 6.11E-172 -0.304598916 p.(G248N) 0.325590049 0 1.595535914 p.(G248D) 0.314116754 5.55E-17 2.015494236 p.(G248C) 0.751903563 3.18E-37 0.075889332 p.(G248Q) 0.292875944 2.78E-16 1.752989943 p.(G248E) 0.329907875 1.18E-23 1.894830935 p.(G248G) 0.209665305 1.39E-17 0.406231321 p.(G248H) 0.826645154 4.33E-157 -0.045198184 p.(G248I) 1.078689376 0 -2.129660209 p.(G248L) 0.456231746 7.05E-53 -0.577188591 p.(G248K) 0.240396396 6.32E-21 1.492687371 p.(G248M) 0.77601031 3.97E-96 0.03375337 p.(G248F) 0.95634057 8.93E-21 -0.777606872 p.(G248P) 0.980984048 4.63E-38 -0.42712086 p.(G248S) 0.457441536 2.18E-83 0.805428364 p.(G248T) 0.463313469 1.70E-38 -0.126360086 p.(G248W) 2.414827932 0 -0.982455803 p.(G248Y) 0.858252536 2.34E-19 -1.230484346 p.(G248V) 1.083202089 1.07E-09 -1.626862797 p.(G261A) 0.733870615 9.50E-29 -0.177046786 p.(G261R) 0.433865882 1.20E-47 0.669894748 p.(G261N) 0.430413504 5.14E-07 0.608447271 p.(G261D) 0.231358552 2.78E-17 -0.398780141 p.(G261C) 0.695903367 1.11E-16 1.483817335 p.(G261Q) 0.326471886 1.66E-43 -0.081315845 p.(G261E) 0.472160512 5.84E-33 0.672114435 p.(G261H) 0.565570955 4.64E-108 -0.032467022 p.(G261I) 0.76032429 4.35E-16 0.259949158 p.(G261L) 0.933084901 3.47E-36 0.244402115 p.(G261K) 0.534660051 9.18E-26 0.777162628 p.(G261M) 0.427785107 2.51E-23 0.242791641 p.(G261F) 0.501935732 1.11E-16 1.076731917 p.(G261P) 1.02797178 4.88E-16 -2.48882933 p.(G261S) 0.716455334 2.20E-68 0.297033724 p.(G261T) 0.271106719 1.64E-35 1.27588754 p.(G261W) 0.073161233 9.67E-51 0.727648916 p.(G261Y) 0.402074778 8.86E-08 0.684058083 p.(G261V) 0.253781054 5.55E-17 -0.429414891 p.(G265A) 0.245621088 3.09E-21 1.034139778 p.(G265R) 0.532838432 3.80E-32 0.500168515 p.(G265N) 0.42739831 2.33E-07 0.772767475 p.(G265D) 0.124047243 5.61E-09 -0.766620273 p.(G265C) 0.245722938 8.33E-17 -0.615605333 p.(G265Q) 0.463255666 4.40E-40 0.718624075 p.(G265E) 0.758377605 2.58E-07 0.197195508 p.(G265G) 0.357888848 0 0.919316349 p.(G265H) 0.536269231 0 0.602648372 p.(G265I) 0.019906166 2.82E-13 1.367493918 p.(G265L) 0.654697381 6.45E-14 0.534638358 p.(G265K) 0.111435658 6.28E-43 0.556023479 p.(G265M) 0.623812809 1.77E-10 1.015640149 p.(G265F) 0.497966122 1.04E-17 0.516515877 p.(G265P) 0.455617374 0.000985416 1.069910528 p.(G265S) 0.375146081 6.27E-54 0.760215866 p.(G265T) 0.524136689 2.22E-16 1.72560768 p.(G265W) 0.40996968 1.60E-12 0.7886351 p.(G265Y) 0.387121915 3.57E-14 0.057061662 p.(G265V) 0.439165675 8.68E-13 0.646919882 p.(H279A) 0.294197676 8.89E-11 -5.060620712 p.(H279R) 0.928489059 1.24E-14 -4.893463655 p.(H279N) 0.788613671 1.06E-70 -2.958508642 p.(H279D) 0.690835853 3.69E-09 -4.895773375 p.(H279C) 0.730896208 1.52E-07 -4.571024831 p.(H279Q) 0.377592435 2.26E-26 -3.178317741 p.(H279E) 0.886901803 1.87E-45 -3.010059806 p.(H279G) 0.826101229 1.75E-08 -4.233504871 p.(H279H) 0.086101716 1.77E-23 -0.370958169 p.(H279I) 0.548086167 8.95E-55 -3.9890117 p.(H279L) 0.821593997 5.77E-20 -1.807730324 p.(H279K) 0.623284533 9.31E-54 -4.246845719 p.(H279M) 0.900875494 1.32E-76 -2.950003462 p.(H279F) 0.741743124 5.66E-10 -3.910291322 p.(H279P) 0.78445995 1.10E-29 -3.627911821 p.(H279S) 0.910351214 2.76E-51 -2.940479637 p.(H279T) 1.494741638 1.78E-15 -2.364142642 p.(H279W) 0.184980278 4.00E-23 -4.711949392 p.(H279Y) 1.036404941 0 -3.151372743 p.(H279V) 0.861469291 1.89E-09 -2.795928918 p.(I251A) 0.291321956 0.00023703 2.818876449 p.(I251R) 0.449808828 0 2.068787226 p.(I251N) 0.456114133 0 1.25666432 p.(I251D) 0.331183821 0.000293367 1.356720537 p.(I251C) 0.309849861 1.29E-34 1.461174358 p.(I251Q) 0.320636843 5.58E-28 0.965548967 p.(I251E) 0.45121118 3.57E-09 2.451744015 p.(I251G) 0.299028683 1.21E-05 3.949050791 p.(I251H) 0.079211354 1.86E-08 0.939252543 p.(I251I) 0.367960741 8.93E-18 1.043614888 p.(I251L) 0.291046046 1.45E-26 0.969291551 p.(I251K) 0.341198368 8.33E-17 1.139103755 p.(I251M) 0.165272603 3.35E-11 0.961609045 p.(I251F) 0.670985949 0 3.239862593 p.(I251P) 0.602914732 2.22E-16 3.184779058 p.(I251S) 0.233158459 2.56E-39 1.943564381 p.(I251T) 0.63331917 2.22E-16 1.55513542 p.(I251W) 0.483107924 5.80E-21 1.378879608 p.(I251Y) 0.382524995 8.33E-17 1.842812739 p.(I251V) 0.250349362 2.90E-41 0.03075202 p.(I256A) 0.70008388 1.34E-26 0.160586699 p.(I256R) 0.554138267 0 0.076822601 p.(I256N) 0.431458729 1.06E-36 -0.324146544 p.(I256D) 0.89984436 8.98E-46 -0.407164406 p.(I256C) 0.290158616 9.36E-15 0.580779964 p.(I256Q) 0.45644293 5.55E-17 0.909779409 p.(I256E) 0.261413175 3.47E-30 0.815011462 p.(I256G) 0.859950049 6.05E-133 0.140914343 p.(I256H) 0.195025855 2.82E-10 -0.196838244 p.(I256I) 0.094128634 2.24E-10 0.100839814 p.(I256L) 0.484602077 5.43E-30 0.76906422 p.(I256K) 0.478477477 1.70E-09 0.160419829 p.(I256M) 0.409589707 5.39E-91 0.628534407 p.(I256F) 0.343002133 4.91E-14 0.621386506 p.(I256P) 2.078662063 0 -4.201440346 p.(I256S) 0.516346072 3.14E-13 0.469342687 p.(I256T) 0.266037904 1.84E-70 0.358695257 p.(I256W) 0.471805344 8.77E-16 0.948543402 p.(I256Y) 0.491698315 8.65E-58 0.19118696 p.(I256V) 0.22670238 0 0.148174675 p.(I258A) 1.036598689 2.56E-13 -3.806070512 p.(I258R) 0.859413573 1.28E-65 -2.984875887 p.(I258N) 0.530323851 1.17E-13 -3.66637957 p.(I258D) 0.739385946 2.99E-18 -3.449454843 p.(I258C) 0.631523049 1.51E-43 -1.242468401 p.(I258Q) 0.703331622 0.000364285 -2.966929102 p.(I258E) 0.734773557 1.04E-11 -3.856541629 p.(I258G) 0.893123225 4.86E-48 -1.554360182 p.(I258H) 0.662276859 1.35E-56 -3.787547665 p.(I258I) 0.084683586 2.37E-20 -0.373794778 p.(I258L) 0.511109021 1.79E-09 1.45500881 p.(I258K) 1.469562818 2.13E-14 -2.787738262 p.(I258M) 0.228881341 2.60E-25 0.232834253 p.(I258F) 0.703117927 1.47E-55 -0.011119972 p.(I258P) 0.840460421 4.78E-16 -3.290930238 p.(I258S) 1.111880199 0 -2.457029646 p.(I258T) 1.02329219 0 -3.575907802 p.(I258W) 0.709610116 2.12E-06 -3.753811272 p.(I258Y) 0.754318328 4.62E-28 -3.518926899 p.(I258V) 0.280513719 8.73E-38 -0.199252409 p.(I266A) 0.442671192 1.67E-16 0.368284695 p.(I266R) 0.356017985 6.67E-27 1.395222269 p.(I266N) 0.405910842 6.43E-21 0.588887354 p.(I266D) 0.782115284 0 1.86518485 p.(I266C) 0.379012094 6.21E-47 0.466926062 p.(I266Q) 0.3602376 6.92E-12 1.52308888 p.(I266E) 0.319687391 2.34E-61 1.681972906 p.(I266G) 0.27046983 1.12E-15 1.294504697 p.(I266H) 0.491292485 1.67E-16 0.705122895 p.(I266I) 0.169458747 2.13E-76 0.088321917 p.(I266L) 0.450824878 1.59E-08 0.463419371 p.(I266K) 0.264195731 9.25E-08 1.046408506 p.(I266M) 0.334553068 1.39E-16 1.12439821 p.(I266F) 0.187363063 1.01E-24 0.86003256 p.(I266P) 0.294277902 1.76E-32 0.864348962 p.(I266S) 0.320215293 1.22E-34 1.037400847 p.(I266T) 0.2117245 1.03E-38 0.359707333 p.(I266W) 0.380829278 1.59E-07 1.59649369 p.(I266Y) 0.536097735 0 1.289328724 p.(I266V) 0.181901135 1.25E-106 1.0846275 p.(I269A) 0.40450367 1.19E-89 0.437483024 p.(I269R) 0.79196963 7.10E-66 0.571030097 p.(I269N) 0.746311749 1.79E-09 -0.511491505 p.(I269D) 0.631397864 2.26E-23 -0.521950379 p.(I269C) 0.762504485 0.001449804 -0.001653426 p.(I269Q) 0.617246864 1.12E-17 0.878237245 p.(I269E) 0.495217636 3.22E-15 0.849279983 p.(I269G) 0.378317689 1.90E-15 0.803290063 p.(I269H) 0.48964542 2.09E-27 0.900681537 p.(I269I) 0.304091782 2.78E-17 0.117112526 p.(I269L) 0.553304941 0 1.10183919 p.(I269K) 0.437626082 1.22E-47 0.798866216 p.(I269M) 0.323487046 6.12E-14 0.571143637 p.(I269F) 0.510566777 2.51E-72 0.517631898 p.(I269P) 0.70206186 5.23E-91 0.345364564 p.(I269S) 0.560398048 1.96E-98 0.297374631 p.(I269T) 0.523059672 1.21E-67 0.108001342 p.(I269W) 0.453783555 7.85E-27 -0.226036201 p.(I269Y) 0.429191216 4.88E-05 -0.034263778 p.(I269V) 0.614202882 0.000200973 1.362649081 p.(I275A) 0.134131076 1.00E-43 0.637995803 p.(I275R) 0.803507158 5.45E-40 -0.014286818 p.(I275N) 0.459936442 1.59E-49 0.005491274 p.(I275D) 0.860441639 5.04E-33 -0.373290271 p.(I275C) 0.339307499 4.04E-39 0.264772677 p.(I275Q) 0.497494134 2.27E-102 0.39125814 p.(I275E) 0.27927714 2.64E-37 1.165259034 p.(I275G) 0.514997315 7.35E-11 0.691019295 p.(I275H) 0.344634503 5.72E-39 0.687445436 p.(I275I) 0.162225184 0.000285646 -0.2118105 p.(I275L) 0.190521895 8.48E-22 0.822820227 p.(I275K) 0.848350283 1.11E-16 -0.019341361 p.(I275M) 0.174607249 1.23E-12 0.803978221 p.(I275F) 0.409173547 5.55E-17 0.870314267 p.(I275P) 0.974960433 2.88E-63 -0.502728055 p.(I275S) 0.165937537 3.96E-31 0.62663822 p.(I275T) 0.30622075 0 0.089076876 p.(I275W) 0.502948971 9.24E-09 0.890250275 p.(I275Y) 0.314804075 6.01E-122 1.404572573 p.(I275V) 0.481933426 0 0.49803866 p.(I277A) 0.912344422 1.75E-40 -0.075222829 p.(I277R) 0.866109489 9.46E-32 -2.848317009 p.(I277N) 0.568644944 3.45E-06 -3.745033063 p.(I277D) 0.72769387 2.49E-37 -4.008278512 p.(I277C) 0.41052619 1.71E-61 0.658071962 p.(I277Q) 0.550413895 0.000512992 -4.086399688 p.(I277E) 0.595182724 7.45E-36 -3.507682911 p.(I277G) 0.947717801 3.01E-17 -2.967000111 p.(I277H) 1.721925687 0 -2.621535995 p.(I277L) 0.333875414 2.23E-11 1.176306121 p.(I277K) 0.623985331 8.97E-55 -3.738644317 p.(I277M) 0.369513984 7.77E-08 0.765267803 p.(I277F) 0.403852423 1.23E-75 0.400934859 p.(I277P) 0.602214756 2.81E-11 -3.456246627 p.(I277S) 1.319317813 4.44E-16 -1.755755047 p.(I277T) 1.193523624 1.23E-22 -1.956182553 p.(I277W) 0.965438769 1.12E-06 -2.338300861 p.(I277Y) 0.496070383 2.91E-11 -0.848827544 p.(I277V) 0.23615851 1.36E-90 0.331594916 p.(I281A) 0.677153058 1.38E-14 -3.54202018 p.(I281R) 0.641861324 1.77E-10 -4.161642637 p.(I281N) 0.587852869 1.41E-38 -3.564170877 p.(I281D) 1.053535918 4.44E-16 -3.590746787 p.(I281C) 0.59549412 8.98E-51 -3.341248739 p.(I281Q) 1.102326856 0 -2.535011999 p.(I281E) 0.928186191 0 -3.164731402 p.(I281G) 0.594817723 2.23E-45 -3.458661057 p.(I281H) 0.579601776 3.06E-05 -4.32994205 p.(I281L) 0.809342374 2.07E-55 -0.13512661 p.(I281K) 0.827600763 1.79E-11 -3.807608297 p.(I281M) 0.350030524 1.55E-34 0.299174145 p.(I281F) 0.946434372 3.60E-53 -3.081856335 p.(I281P) 1.596767465 0 -3.819981218 p.(I281S) 0.508455081 7.35E-37 -3.480899151 p.(I281T) 0.889708507 7.11E-15 -3.371830515 p.(I281W) 0.863008465 0.001025821 -3.441310845 p.(I281Y) 1.209861541 0 -4.05700068 p.(I281V) 1.02431309 3.32E-31 -1.231613972 p.(L253A) 0.570772964 2.28E-28 0.653350665 p.(L253R) 0.307526793 7.71E-25 0.501193476 p.(L253N) 0.43737244 0 1.004123315 p.(L253D) 0.297779409 2.49E-07 1.405041732 p.(L253C) 0.621181682 0 0.912723253 p.(L253Q) 1.042528259 0 1.81252413 p.(L253E) 0.449091299 2.72E-10 1.741357042 p.(L253G) 0.145159478 5.60E-41 1.027056048 p.(L253H) 0.413136312 8.63E-30 -0.087808179 p.(L253I) 0.202239221 0 0.227339303 p.(L253L) 0.497486618 0 0.404331049 p.(L253K) 0.271534021 1.88E-31 0.566049081 p.(L253M) 0.558660368 1.11E-16 1.759946177 p.(L253F) 0.227836339 1.39E-17 -0.641178452 p.(L253P) 0.786793513 6.66E-16 2.153100112 p.(L253S) 0.092745894 1.39E-20 1.37942707 p.(L253T) 0.414442272 7.41E-15 1.713877195 p.(L253W) 0.384059213 2.92E-18 1.037857278 p.(L253Y) 0.502181885 0 1.293739865 p.(L253V) 0.511311067 2.73E-14 1.178332153 p.(L271A) 0.562161029 1.16E-45 -0.530790273 p.(L271R) 0.750185438 2.82E-41 -0.901505266 p.(L271N) 0.76576993 5.10E-76 0.270127262 p.(L271D) 0.602376635 2.14E-34 -0.365461838 p.(L271C) 0.441086267 1.02E-62 0.374088471 p.(L271Q) 0.470946379 1.44E-92 -0.647722304 p.(L271E) 0.844752571 4.40E-12 -0.633022696 p.(L271G) 0.791827779 6.84E-33 -0.418821389 p.(L271H) 0.708400224 5.74E-114 -0.396997451 p.(L271I) 0.283760135 1.38E-23 -0.124041994 p.(L271L) 0.088553207 7.29E-19 -0.147794397 p.(L271K) 0.499737914 4.07E-08 -0.44139315 p.(L271M) 0.834264508 8.88E-16 1.080389265 p.(L271F) 0.583113727 2.79E-16 0.699994574 p.(L271P) 0.268053976 1.23E-20 -0.463095639 p.(L271S) 0.693746993 1.36E-36 -0.540439081 p.(L271T) 0.952798151 3.84E-83 0.2199748 p.(L271W) 0.36322311 5.27E-09 1.009784975 p.(L271Y) 0.520043763 9.51E-80 0.010433482 p.(L271V) 0.351173533 1.13E-08 0.377196915 p.(L287A) 0.66955783 2.10E-07 -3.809464016 p.(L287R) 1.069292454 1.48E-97 -2.455186499 p.(L287N) 0.828876837 3.34E-66 -3.35344609 p.(L287D) 0.314167162 8.44E-16 -4.461684074 p.(L287C) 0.924429573 4.91E-08 -2.943619693 p.(L287Q) 0.626047309 1.57E-08 -3.341306823 p.(L287E) 0.420168513 3.35E-27 -4.761918685 p.(L287G) 0.9914621 1.97E-13 -2.627787197 p.(L287H) 0.546595962 8.04E-25 -4.516829547 p.(L287I) 0.557281043 1.07E-17 -0.631909134 p.(L287L) 0.452145449 8.86E-13 1.287168386 p.(L287K) 0.646846897 2.81E-60 -3.446172686 p.(L287M) 0.54397639 2.18E-35 0.134218891 p.(L287F) 0.456415365 0 0.51971118 p.(L287P) 0.599613696 2.22E-16 -2.562963045 p.(L287S) 0.704729147 6.23E-18 -2.586739046 p.(L287T) 0.649846785 4.48E-07 -2.983101239 p.(L287W) 0.65958253 6.47E-06 -3.617732996 p.(L287Y) 1.401799025 1.78E-15 -3.175633489 p.(L287V) 0.926647431 1.31E-45 -2.6993239 p.(L290A) 0.744689292 2.50E-36 0.319009517 p.(L290R) 1.49791109 7.77E-105 -1.670593946 p.(L290N) 0.888656191 6.45E-79 -1.302563661 p.(L290D) 1.786484538 0 -2.073546458 p.(L290C) 0.35755353 5.50E-26 0.860824247 p.(L290Q) 0.951348357 1.01E-07 -0.769655085 p.(L290E) 1.888096701 0 -4.294823873 p.(L290G) 0.556676204 8.70E-67 -4.060761842 p.(L290H) 0.519664268 2.44E-48 0.305895092 p.(L290I) 0.408064756 1.05E-17 0.637898439 p.(L290L) 0.145163132 1.70E-07 -0.072770283 p.(L290K) 1.088353296 3.62E-53 -0.283914093 p.(L290M) 0.285756324 4.95E-66 0.690525123 p.(L290F) 0.397155938 3.80E-14 0.603744001 p.(L290P) 0.742629581 1.25E-33 -2.367870743 p.(L290S) 0.955401006 4.14E-23 0.159582291 p.(L290T) 0.671222288 1.72E-55 0.101629315 p.(L290W) 0.169574309 1.37E-25 0.439653509 p.(L290Y) 0.423140788 2.06E-07 0.628464292 p.(L290V) 0.284041205 3.64E-08 -1.696911363 p.(K292A) 0.379260948 5.09E-07 1.451573194 p.(K292R) 0.446583906 1.50E-26 1.019014864 p.(K292N) 0.911254548 7.80E-115 -0.411922237 p.(K292D) 0.78878975 3.06E-06 -4.133585625 p.(K292C) 0.204920417 7.18E-61 1.205208982 p.(K292Q) 0.317281799 4.57E-39 0.828190854 p.(K292E) 0.498303435 2.95E-90 -0.203020265 p.(K292G) 0.812558043 1.16E-66 -0.510033268 p.(K292H) 0.7961123 3.71E-31 0.049472442 p.(K292I) 1.182713194 2.12E-55 -1.934033684 p.(K292L) 1.035262481 2.55E-79 -1.896099056 p.(K292K) 0.193595477 1.98E-22 -0.015568152 p.(K292M) 0.61292918 5.72E-07 1.040094749 p.(K292F) 0.226840781 1.69E-66 0.719816471 p.(K292P) 0.117423643 5.98E-36 1.658433772 p.(K292S) 0.326446711 3.44E-52 1.115674776 p.(K292T) 0.837062331 3.35E-35 -3.191072928 p.(K292W) 0.838464925 4.40E-111 -0.300771323 p.(K292Y) 0.447675803 1.22E-15 1.510616065 p.(K292V) 0.967751967 1.48E-28 -0.85659383 p.(F262A) 0.722515062 0.005444878 -0.184130638 p.(F262R) 1.055392748 9.58E-59 0.094121458 p.(F262N) 0.596710852 4.37E-94 -0.313329915 p.(F262D) 0.771762192 1.72E-64 -0.700772964 p.(F262C) 0.350827543 8.12E-131 0.41811915 p.(F262Q) 1.010024413 4.79E-15 -0.503078428 p.(F262E) 1.077992977 3.85E-45 -0.694368048 p.(F262G) 0.784658394 9.09E-107 -0.258105259 p.(F262H) 0.767344394 1.81E-40 -0.220513009 p.(F262I) 0.678331022 4.44E-16 1.884258258 p.(F262L) 0.420766742 1.74E-17 1.119281472 p.(F262K) 1.090231727 5.31E-25 -0.198816274 p.(F262M) 0.524359203 2.03E-17 1.061982302 p.(F262F) 0.112329309 8.45E-44 -0.420569127 p.(F262P) 0.752400242 3.72E-11 -0.028533431 p.(F262S) 0.60944897 3.59E-69 -0.214320662 p.(F262T) 0.657214294 2.22E-16 0.819839304 p.(F262W) 0.180741402 3.46E-60 0.826768615 p.(F262Y) 0.317630428 2.35E-76 0.501589502 p.(F262V) 0.185474553 1.44E-73 0.600299967 p.(F270A) 0.25961916 1.42E-90 0.662762621 p.(F270R) 0.802052842 3.78E-33 -0.506768478 p.(F270N) 1.08428228 6.13E-09 0.107343113 p.(F270D) 0.453343956 2.78E-17 0.892255189 p.(F270C) 0.361846305 3.28E-47 0.451213799 p.(F270Q) 0.450610713 0.001508433 1.012240394 p.(F270E) 0.831040101 4.43E-86 0.106123047 p.(F270G) 0.936947019 6.69E-28 -0.528844767 p.(F270H) 0.4619538 5.38E-53 0.17385698 p.(F270I) 0.065815071 2.27E-25 1.134493299 p.(F270L) 0.392246379 2.23E-29 0.956083018 p.(F270K) 0.555087434 1.43E-96 -0.099495744 p.(F270M) 0.505344592 1.75E-36 0.099860791 p.(F270F) 0.064225197 1.66E-40 0.199670689 p.(F270P) 0.530905177 6.13E-57 0.234731067 p.(F270S) 0.316912924 1.79E-11 0.203972824 p.(F270T) 0.400460755 2.78E-17 0.46278276 p.(F270W) 0.353000121 2.10E-34 0.407708298 p.(F270Y) 0.774312723 6.07E-87 0.843257461 p.(F270V) 0.320361837 1.39E-10 0.975788849 p.(P252A) 0.344488688 1.70E-52 1.15395548 p.(P252N) 1.632847008 3.55E-15 4.174608132 p.(P252D) 0.725131653 6.33E-30 2.425264436 p.(P252C) 0.483432574 2.22E-16 2.006242224 p.(P252Q) 0.222275744 2.30E-24 0.414632654 p.(P252E) 0.646606198 4.53E-37 2.939376561 p.(P252G) 0.227935001 1.10E-07 2.473281123 p.(P252H) 0.239289678 0.001528738 2.905068808 p.(P252I) 0.520390626 1.11E-16 3.333122525 p.(P252L) 0.229338819 3.60E-64 0.299035203 p.(P252K) 0.58898287 0 2.310543583 p.(P252M) 0.454062672 0.002711192 3.211605097 p.(P252F) 0.316240898 1.17E-29 1.874088499 p.(P252P) 0.222643123 7.08E-64 0.191115848 p.(P252S) 0.413851098 1.12E-07 2.01150827 p.(P252T) 0.421186251 5.59E-10 1.557466359 p.(P252W) 0.532147257 1.65E-21 1.879204824 p.(P252Y) 0.565344422 1.40E-05 2.474964843 p.(P252V) 0.523625927 4.67E-30 2.021971171 p.(P274A) 0.616011966 1.88E-23 0.470416178 p.(P274R) 0.437553648 3.15E-07 -2.258116451 p.(P274N) 0.955798265 7.36E-08 -1.471348474 p.(P274D) 0.413236699 5.33E-13 1.050366684 p.(P274C) 0.306187198 4.89E-48 0.863070301 p.(P274Q) 1.003512519 1.52E-26 -0.665593307 p.(P274E) 0.412455075 9.10E-25 0.417197827 p.(P274G) 0.594753511 3.87E-27 1.110905116 p.(P274H) 0.820463401 2.37E-35 -0.095518756 p.(P274I) 0.882952803 9.35E-28 -1.489307705 p.(P274L) 0.315620334 7.73E-29 -1.184193798 p.(P274K) 0.610792408 2.73E-44 -3.573661312 p.(P274M) 0.694252143 1.39E-32 0.170435793 p.(P274F) 0.641728141 6.49E-123 -0.205830721 p.(P274P) 0.183287677 5.37E-08 0.207359586 p.(P274S) 0.320644064 2.78E-17 -0.980661332 p.(P274T) 0.48662137 9.86E-36 0.477067817 p.(P274W) 1.180147094 1.15E-05 0.845594536 p.(P274Y) 0.767259962 3.47E-08 0.046744327 p.(P274V) 0.676350455 4.95E-34 -0.136409248 p.(P286A) 1.112518265 5.60E-42 -0.942257927 p.(P286R) 0.983383845 6.66E-16 -3.898243883 p.(P286N) 1.182954051 4.44E-16 -4.010049406 p.(P286D) 0.604741847 2.00E-07 -2.770334695 p.(P286C) 0.967955045 1.86E-06 -2.488830308 p.(P286Q) 0.689416936 3.94E-36 -3.945320263 p.(P286E) 0.613962965 2.16E-38 -3.157501869 p.(P286G) 0.841841669 6.06E-18 -3.205042017 p.(P286H) 0.39044252 5.39E-40 -3.492372932 p.(P286I) 0.858978497 4.14E-29 -3.303634386 p.(P286L) 0.822169232 0 -3.688729627 p.(P286K) 0.942096949 2.22E-16 -3.671688069 p.(P286M) 0.756670862 0.000163732 -3.356371754 p.(P286F) 0.812161913 3.47E-43 -1.723460147 p.(P286P) 0.220544565 2.04E-14 0.153767851 p.(P286S) 0.624406604 6.32E-54 -3.718378529 p.(P286T) 0.680511472 6.22E-26 -3.855566776 p.(P286W) 1.598585328 3.58E-06 -2.271261717 p.(P286Y) 1.438289804 6.13E-47 -1.707042251 p.(P286V) 1.377706938 1.60E-53 -1.618614854 p.(S246A) 0.717198692 3.32E-55 -0.02031736 p.(S246R) 0.169081743 9.33E-75 0.297521148 p.(S246N) 0.127341932 0 0.774269198 p.(S246D) 0.280919076 5.19E-27 1.281672098 p.(S246C) 0.425792488 2.03E-07 -0.091614622 p.(S246Q) 0.171555175 2.37E-81 0.728000081 p.(S246E) 0.297401595 3.29E-19 0.83599299 p.(S246G) 0.510117026 8.76E-64 1.076000856 p.(S246H) 0.635421862 1.69E-61 0.362156923 p.(S246I) 0.540813213 6.30E-07 0.192101469 p.(S246L) 0.471079923 9.47E-44 0.521607361 p.(S246K) 0.595938414 2.13E-67 1.609031266 p.(S246M) 0.35906983 1.10E-28 0.331359804 p.(S246F) 0.642989269 4.95E-34 -0.268388353 p.(S246P) 0.520363655 4.61E-34 1.548265363 p.(S246S) 0.204124245 3.49E-31 0.725541358 p.(S246T) 0.348000926 6.44E-61 0.72802462 p.(S246W) 0.883805064 1.99E-128 -0.095019621 p.(S246Y) 0.633061156 2.26E-57 -0.718740843 p.(S246V) 0.39798148 1.32E-41 0.537873699 p.(S264A) 0.302197177 5.09E-53 0.862666362 p.(S264R) 0.174121644 6.17E-08 1.256670138 p.(S264N) 0.23564963 2.78E-17 0.257358133 p.(S264D) 1.051811755 4.44E-16 2.349449407 p.(S264C) 0.413421352 8.64E-36 1.179924595 p.(S264Q) 0.13004099 4.25E-23 0.241014513 p.(S264E) 0.589164626 0 1.489846175 p.(S264G) 0.687545923 3.67E-10 -0.193155892 p.(S264H) 0.36542134 8.66E-98 0.395475471 p.(S264I) 0.611629618 4.33E-40 0.626283687 p.(S264L) 0.220021678 3.39E-07 0.731614406 p.(S264K) 0.27940216 1.64E-18 1.792149225 p.(S264M) 0.370029245 6.01E-88 0.812893953 p.(S264F) 0.542527005 0 1.263089608 p.(S264P) 0.620026723 5.61E-46 -0.530554517 p.(S264T) 0.371945829 1.94E-16 1.274523545 p.(S264W) 0.614642199 1.20E-13 1.819573191 p.(S264Y) 0.441202975 1.64E-07 0.589293208 p.(S264V) 0.460458558 3.55E-48 0.850872725 p.(S273A) 0.319515891 1.63E-33 0.322217124 p.(S273R) 0.290390549 1.30E-09 0.779652975 p.(S273N) 0.181384262 1.14E-145 0.011258382 p.(S273D) 0.954665451 3.33E-36 -0.268964389 p.(S273C) 0.511306482 1.05E-11 0.454909408 p.(S273Q) 0.358075989 2.78E-16 1.318944612 p.(S273E) 0.923999548 0.000643021 0.035409836 p.(S273G) 0.681156071 3.33E-16 1.052793966 p.(S273H) 0.843471069 0 1.02045178 p.(S273I) 0.683004944 4.93E-08 -1.136713053 p.(S273L) 0.903940479 6.84E-35 -0.441885505 p.(S273K) 0.913820987 0 1.981016491 p.(S273M) 0.898139366 1.37E-06 -0.037556931 p.(S273F) 0.694940235 9.83E-34 0.340555965 p.(S273P) 1.033926036 1.03E-35 0.024945953 p.(S273S) 0.302309754 1.34E-28 0.8779703 p.(S273T) 0.265873237 5.21E-16 0.664967554 p.(S273W) 0.595083847 6.62E-51 -0.057046411 p.(S273Y) 0.201517973 6.37E-81 0.592580514 p.(S273V) 0.828213852 1.22E-20 1.081988358 p.(S285A) 0.613023825 1.20E-23 -4.642089042 p.(S285R) 0.571198998 2.10E-36 -3.819042154 p.(S285N) 0.575704212 5.20E-19 -4.00837541 p.(S285D) 0.632864622 0.000305293 -3.367050129 p.(S285C) 0.513419301 1.05E-05 -4.59892237 p.(S285Q) 1.354323221 0 -3.467207194 p.(S285E) 0.840840588 1.81E-16 -2.904794207 p.(S285G) 0.684860822 2.07E-08 -2.754289993 p.(S285H) 0.553562652 1.22E-61 -4.143344787 p.(S285I) 0.485128005 5.80E-14 -3.757149864 p.(S285L) 0.756318948 3.67E-08 -3.730655301 p.(S285K) 1.014787046 0.000100177 -2.468291738 p.(S285M) 0.922175679 0 -3.852270813 p.(S285F) 0.681127314 7.84E-07 -4.426606798 p.(S285P) 0.597882464 5.59E-23 -3.59783351 p.(S285S) 0.488163753 0 1.238532136 p.(S285T) 0.934763619 6.66E-16 -4.315180255 p.(S285W) 0.81287341 5.67E-19 -3.223145936 p.(S285Y) 0.525895715 5.79E-44 -3.004713032 p.(S285V) 1.046100597 0 -2.830340573 p.(S291A) 0.200537066 4.96E-51 0.661594252 p.(S291R) 0.38258753 1.94E-16 0.781234825 p.(S291N) 0.329589794 2.50E-71 0.754334362 p.(S291D) 0.259376195 2.75E-65 0.878067512 p.(S291C) 0.135897306 1.25E-20 0.484620759 p.(S291Q) 0.730091688 3.22E-121 -0.252993364 p.(S291E) 0.619245982 1.42E-10 -1.421134206 p.(S291G) 0.46420447 3.00E-85 0.365755476 p.(S291H) 0.743103701 1.59E-11 0.648656171 p.(S291I) 0.543757361 0.005196958 -3.974020819 p.(S291L) 0.726964773 1.95E-12 -3.465740393 p.(S291K) 0.367993371 4.42E-06 0.410877621 p.(S291M) 1.351143329 2.22E-15 -2.570753526 p.(S291F) 0.261965274 1.56E-74 -2.945732181 p.(S291P) 1.548380594 0 -1.589143205 p.(S291T) 0.278526327 0 0.549248698 p.(S291W) 1.108676882 4.44E-16 -3.485731921 p.(S291Y) 0.464605873 2.86E-14 -3.742593233 p.(S291V) 0.290020778 1.99E-31 -4.764683575 p.(T245A) 0.40828414 6.69E-09 0.983611671 p.(T245R) 0.421489497 0 1.19510808 p.(T245N) 0.345283864 8.08E-15 1.793906163 p.(T245D) 0.272836294 0.000296987 0.918171841 p.(T245C) 0.501414706 8.99E-09 2.061231973 p.(T245Q) 0.268807097 1.48E-33 1.814490687 p.(T245E) 0.317881173 0.00064218 0.427015321 p.(T245G) 0.684228723 0 2.108589399 p.(T245H) 0.564439969 1.11E-16 1.836114726 p.(T245I) 0.126606799 1.20E-06 -0.670011097 p.(T245L) 0.658709504 5.34E-29 -0.09538935 p.(T245K) 0.637633775 5.55E-16 0.22889063 p.(T245M) 0.421401538 1.39E-25 1.973280869 p.(T245F) 0.623592583 7.73E-25 0.129601916 p.(T245P) 0.394509168 1.37E-13 1.395814041 p.(T245S) 0.420965671 1.11E-16 0.566944479 p.(T245T) 0.282920516 1.54E-42 0.816384141 p.(T245W) 0.439377649 3.14E-06 -0.097625207 p.(T245Y) 0.49554994 2.89E-27 0.6463315 p.(T245V) 0.32759108 6.73E-50 0.953988025 p.(T276A) 0.749011031 2.74E-37 0.228340148 p.(T276R) 0.821394226 1.28E-27 -1.748969098 p.(T276N) 0.259163507 2.78E-17 0.070873926 p.(T276D) 0.448471107 4.17E-33 1.309715862 p.(T276C) 0.619730875 1.26E-20 -0.360131313 p.(T276Q) 0.425230476 4.64E-68 0.63195975 p.(T276E) 0.538566891 1.28E-65 1.165167068 p.(T276G) 1.219184472 7.47E-41 -0.391539628 p.(T276H) 0.535436927 0 0.162349717 p.(T276I) 0.173868904 3.36E-115 -0.053210515 p.(T276L) 0.376273793 4.57E-85 0.833535617 p.(T276K) 1.181269836 1.35E-46 -1.070849239 p.(T276M) 0.233454882 2.72E-97 0.493435138 p.(T276F) 0.961762512 4.00E-68 -0.014418205 p.(T276P) 1.484818031 7.18E-62 0.778606923 p.(T276S) 0.457988257 2.30E-52 0.774691511 p.(T276T) 0.190474991 0 -0.32129662 p.(T276W) 0.57951863 8.91E-32 -4.400749199 p.(T276Y) 0.107898346 3.04E-39 0.212952244 p.(T276V) 0.414149293 1.74E-18 1.231580186 p.(Y250A) 1.49541635 0 4.126545097 p.(Y250R) 0.523785059 1.12E-52 1.907685265 p.(Y250N) 0.547313675 2.69E-09 2.102829138 p.(Y250D) 1.290400354 6.00E-13 5.682013386 p.(Y250C) 0.350960938 1.39E-119 0.481605686 p.(Y250Q) 0.878723565 0 3.705374241 p.(Y250E) 0.532500027 0.001325275 2.251333966 p.(Y250G) 0.624301721 2.22E-16 4.497434976 p.(Y250H) 0.684656523 0 2.919070953 p.(Y250I) 0.559388881 4.24E-12 2.947785193 p.(Y250L) 0.527671992 1.10E-68 2.120228923 p.(Y250K) 0.873701518 4.10E-12 3.268840435 p.(Y250M) 0.927365368 1.32E-05 3.408859786 p.(Y250F) 0.16537033 2.19E-32 0.611307057 p.(Y250P) 0.552551935 2.17E-41 3.039325885 p.(Y250S) 0.648980382 8.72E-30 2.599837606 p.(Y250T) 0.757183595 1.22E-15 4.306392216 p.(Y250W) 0.480130534 6.41E-64 0.835102933 p.(Y250Y) 0.115377278 6.94E-18 -0.340106122 p.(Y250V) 0.547326801 2.76E-09 2.01506284 p.(Y288A) 0.831636244 0.003236028 -2.391970177 p.(Y288R) 0.324641071 2.61E-39 -1.410578997 p.(Y288N) 0.642334845 2.30E-14 -4.124728095 p.(Y288D) 0.701064933 6.62E-50 -3.954805285 p.(Y288C) 0.444122827 8.37E-167 -2.954220902 p.(Y288Q) 0.476431498 1.15E-15 -4.477261101 p.(Y288E) 0.746229967 3.87E-14 -4.417293477 p.(Y288G) 1.075274846 4.44E-16 -2.931246066 p.(Y288H) 0.448010929 3.34E-59 -2.342149968 p.(Y288I) 0.776774001 1.11E-10 -3.058790823 p.(Y288L) 0.66001597 1.80E-55 -3.634575458 p.(Y288K) 1.135162577 3.47E-11 -3.610558051 p.(Y288M) 1.157058429 8.88E-16 -3.440708919 p.(Y288F) 0.199851264 5.75E-53 0.555041219 p.(Y288P) 0.768103318 4.68E-32 -3.626668489 p.(Y288S) 0.434001944 3.85E-20 -4.666734565 p.(Y288T) 0.400224361 9.61E-32 -4.281492782 p.(Y288W) 0.313105462 3.58E-13 1.299254341 p.(Y288V) 1.020608053 3.82E-14 -3.747728839 p.(V260A) 0.478332186 1.10E-24 0.526130933 p.(V260R) 0.548204142 1.05E-07 -4.69570562 p.(V260N) 0.652077825 8.56E-13 -4.270479258 p.(V260D) 0.77258986 0.00131809 -2.663965398 p.(V260C) 0.664355885 5.79E-10 1.713572032 p.(V260Q) 0.768744132 1.76E-55 -3.734479851 p.(V260E) 0.475230991 2.33E-55 -3.953430234 p.(V260G) 0.527040449 3.99E-93 -4.113679203 p.(V260H) 0.85290764 6.51E-35 -0.961036699 p.(V260I) 0.365695706 1.42E-72 0.139408868 p.(V260L) 1.017063522 2.61E-37 -0.094642495 p.(V260K) 0.756566731 1.20E-23 -2.422045454 p.(V260M) 0.373346066 1.60E-40 -0.88984137 p.(V260F) 1.185072373 6.08E-44 -1.271662157 p.(V260P) 0.529004784 4.94E-64 -4.321185213 p.(V260S) 1.586298529 2.66E-15 -4.170664595 p.(V260T) 0.813840914 9.57E-97 -0.109911024 p.(V260W) 0.352706347 1.87E-35 -3.842773594 p.(V260Y) 1.297200114 0 -3.25044843 p.(V260V) 0.082009976 5.14E-22 -0.354753664 p.(V272A) 0.604256832 0 1.52472613 p.(V272R) 0.551148293 4.47E-101 0.461284732 p.(V272N) 0.784570296 1.82E-73 0.03299877 p.(V272D) 0.651153159 2.56E-21 1.719623769 p.(V272C) 0.447325628 3.30E-37 0.17361124 p.(V272Q) 0.482284507 0.002304748 0.205455636 p.(V272E) 0.348147083 0 0.690185095 p.(V272G) 0.600990859 1.99E-66 0.660005417 p.(V272H) 0.723439427 3.30E-49 0.279413278 p.(V272I) 0.515600173 1.32E-07 1.341000753 p.(V272L) 0.410357297 1.96E-28 0.765706356 p.(V272K) 0.291235129 0.001389379 0.307777243 p.(V272M) 0.596570717 2.22E-16 2.419174804 p.(V272F) 0.232996507 4.97E-29 1.054988433 p.(V272P) 0.344321048 6.19E-10 0.125634602 p.(V272S) 0.238834517 4.62E-41 0.621424537 p.(V272T) 0.457606774 2.35E-30 0.39949306 p.(V272W) 0.531480822 1.99E-17 0.876053187 p.(V272Y) 0.705893684 4.66E-15 0.66916161 p.(V272V) 0.114639852 9.45E-29 0.250289845 p.(V278A) 0.926456095 1.06E-81 -0.42685667 p.(V278R) 0.907466904 5.41E-74 -0.381589753 p.(V278N) 1.028859841 4.01E-51 -1.149000294 p.(V278D) 0.436904366 4.20E-16 -4.125859667 p.(V278C) 0.534340698 3.07E-29 0.912974081 p.(V278Q) 0.897456816 6.67E-33 -0.749850943 p.(V278E) 1.080631903 1.96E-22 -2.048237937 p.(V278G) 1.337648259 0 -3.060312535 p.(V278H) 1.301478669 1.19E-81 -0.533551784 p.(V278I) 0.235032748 6.09E-51 0.755361269 p.(V278L) 0.570551193 7.13E-35 0.703065699 p.(V278K) 0.865431941 9.08E-63 -0.001995836 p.(V278M) 0.35365212 1.52E-40 0.03766786 p.(V278F) 0.095364242 7.06E-26 -0.307262882 p.(V278P) 0.71823491 4.69E-81 -3.573136255 p.(V278S) 0.690560236 2.86E-38 0.059835933 p.(V278T) 0.737172296 6.01E-56 -0.061463807 p.(V278W) 1.085647902 2.13E-10 -0.20611452 p.(V278Y) 0.338817369 5.51E-19 0.568980342 p.(V278V) 0.132052133 6.94E-18 0.141733592 p.(A298A) 0.093796679 9.72E-23 -0.16872618 p.(A298R) 0.893138327 3.55E-28 -0.850582462 p.(A298N) 0.600887934 5.15E-89 0.081975305 p.(A298D) 0.268656748 0 -0.669492833 p.(A298C) 0.46252613 4.95E-43 0.222248937 p.(A298Q) 0.443298089 5.11E-41 0.74618651 p.(A298E) 0.280370869 5.01E-12 0.279386675 p.(A298G) 0.576057289 0 0.280060001 p.(A298H) 0.853853151 5.62E-61 0.106269932 p.(A298I) 0.456616291 3.42E-56 0.36803877 p.(A298L) 0.389492354 3.82E-26 0.92196124 p.(A298K) 1.004206755 1.15E-57 -0.087207423 p.(A298M) 0.565875721 2.05E-26 0.490978978 p.(A298F) 0.558753731 9.20E-42 -1.495878074 p.(A298P) 0.69871966 5.06E-71 -3.118403545 p.(A298S) 0.400838534 2.28E-06 0.584767164 p.(A298T) 0.419609935 1.50E-67 0.517224101 p.(A298W) 0.477558007 3.77E-98 -0.393438452 p.(A298Y) 1.40117188 0 -1.430469745 p.(A298V) 0.306019909 0 0.180779498 p.(A312A) 0.066427717 1.36E-18 -0.527780913 p.(A312R) 0.514286303 3.51E-26 1.064790834 p.(A312N) 0.44422188 5.09E-41 -0.071847783 p.(A312D) 0.190305819 6.14E-48 -0.338765931 p.(A312C) 0.446486349 2.79E-17 0.830765482 p.(A312Q) 0.622355516 1.11E-16 0.828385798 p.(A312G) 0.323152263 4.76E-11 0.84793195 p.(A312H) 0.684043715 6.61E-10 0.225764562 p.(A312I) 0.558975894 1.59E-49 0.384241593 p.(A312L) 0.736025524 0 0.460611748 p.(A312K) 0.587272386 1.26E-23 0.104589393 p.(A312M) 0.350072423 2.09E-12 0.1803332 p.(A312F) 0.551340517 1.09E-37 -0.703699243 p.(A312P) 0.446189251 1.45E-59 0.607985112 p.(A312S) 0.420209772 5.55E-17 0.286395068 p.(A312T) 0.087195991 1.05E-74 -0.814229957 p.(A312W) 0.392928449 1.38E-14 0.34167936 p.(A312Y) 0.665807161 1.11E-12 0.651660147 p.(A312V) 0.157010378 4.47E-12 -0.811498937 p.(A314R) 0.555456557 4.18E-32 0.630058468 p.(A314N) 0.398427179 6.22E-30 0.448302226 p.(A314D) 0.185731408 1.85E-13 -0.933943411 p.(A314C) 1.381724277 3.55E-15 1.781073477 p.(A314Q) 0.629365608 2.71E-172 -0.612183432 p.(A314E) 0.298891187 4.61E-30 1.587056682 p.(A314G) 0.42937537 5.33E-13 1.072381174 p.(A314H) 0.274165007 2.58E-36 1.249965131 p.(A314I) 0.277461656 3.75E-45 -0.262996487 p.(A314L) 0.411608136 1.89E-41 0.527409008 p.(A314K) 0.433492089 3.86E-30 -0.122359696 p.(A314M) 0.914177411 0 2.801166163 p.(A314F) 0.384805159 2.26E-06 0.457392493 p.(A314P) 0.396411224 2.39E-85 -0.129044005 p.(A314S) 0.29024018 5.60E-13 1.047220394 p.(A314T) 0.463722376 5.70E-10 0.076797212 p.(A314W) 0.527099305 0.000177134 0.807818999 p.(A314Y) 0.432080256 0 0.332997974 p.(A314V) 0.359672381 1.00E-20 0.414656674 p.(A325R) 0.8095569 8.42E-15 0.391149111 p.(A325N) 0.395858689 5.09E-44 0.709017166 p.(A325D) 0.279103777 6.42E-99 -2.422214254 p.(A325C) 0.406000896 1.82E-73 0.152986315 p.(A325Q) 1.018431712 1.06E-55 -0.181933412 p.(A325E) 1.174755543 1.34E-29 -2.114234705 p.(A325G) 0.311729926 2.99E-46 0.753914068 p.(A325H) 0.431014977 6.31E-47 0.886029531 p.(A325I) 1.177495501 3.43E-43 -2.452055029 p.(A325L) 0.679268232 3.00E-16 -3.769010266 p.(A325K) 1.155290238 1.59E-18 -1.36595144 p.(A325M) 1.342903636 2.17E-57 -0.820451369 p.(A325F) 1.243365602 3.24E-41 -2.644120844 p.(A325P) 0.529803676 6.43E-51 0.033337633 p.(A325S) 0.352996583 4.45E-10 0.442607094 p.(A325T) 0.729002179 2.94E-28 0.485563246 p.(A325W) 0.862613168 1.16E-43 -1.27594778 p.(A325Y) 1.374300955 4.20E-15 -1.664941723 p.(A325V) 0.135555262 1.60E-43 -1.044251251 p.(R320A) 0.274486711 4.01E-43 0.563828309 p.(R320N) 0.345541729 4.01E-13 -0.141951521 p.(R320D) 1.066065108 7.84E-19 -2.149636797 p.(R320C) 0.476307569 1.30E-10 0.090315102 p.(R320Q) 0.270310991 2.78E-17 -0.620360733 p.(R320E) 0.324290529 1.01E-28 1.038051715 p.(R320G) 0.442605782 2.26E-10 0.482629011 p.(R320H) 0.702257968 0 0.807235398 p.(R320I) 0.488219926 4.50E-62 0.951475295 p.(R320L) 0.522493084 0 1.046642515 p.(R320K) 0.431497509 9.78E-09 1.100552812 p.(R320M) 0.823152871 7.83E-104 -0.107040012 p.(R320F) 0.613520782 2.11E-11 1.393881864 p.(R320P) 0.973853333 4.60E-104 -2.229761556 p.(R320S) 0.656904272 2.22E-16 2.117971626 p.(R320T) 0.592257548 1.33E-46 0.603062789 p.(R320W) 0.36632599 9.60E-13 0.537118838 p.(R320Y) 0.594246416 6.45E-20 0.423963163 p.(R320V) 0.376529205 1.14E-38 0.780970915 p.(R333A) 0.258906118 1.69E-08 2.530690045 p.(R333R) 0.209117768 1.43E-39 0.914262977 p.(R333N) 0.535453313 2.52E-26 2.304311214 p.(R333D) 0.428222283 5.35E-59 2.468700866 p.(R333C) 0.380368807 5.28E-27 1.631593763 p.(R333Q) 0.725924127 4.44E-16 4.861452005 p.(R333E) 0.591493912 2.67E-25 1.171220048 p.(R333G) 0.361220635 2.67E-33 2.935193908 p.(R333H) 0.26584176 9.14E-24 0.040254448 p.(R333I) 0.275276611 2.70E-06 2.289545468 p.(R333L) 0.55713663 2.51E-09 2.006998275 p.(R333K) 0.514342009 1.11E-16 0.994810151 p.(R333M) 1.042911221 8.88E-16 2.628835375 p.(R333F) 0.261070456 6.62E-14 2.691019333 p.(R333P) 0.496402719 8.52E-15 -4.497015049 p.(R333S) 0.491387751 0 1.979332354 p.(R333T) 0.279845792 5.55E-38 3.747522496 p.(R333W) 0.679018732 0 1.434207885 p.(R333Y) 0.235173874 5.19E-29 1.673128193 p.(R333V) 0.284296026 1.58E-17 1.951250079 p.(N297A) 0.426496223 0 0.953716275 p.(N297R) 0.696670889 6.04E-29 0.250361544 p.(N297D) 0.046881273 3.70E-21 0.380978715 p.(N297C) 0.232308518 5.97E-05 0.697727384 p.(N297Q) 0.351463065 6.21E-84 0.920530211 p.(N297E) 0.530742894 0 1.279225894 p.(N297G) 0.353890552 1.28E-29 0.189996121 p.(N297H) 0.702144622 3.83E-24 1.21520752 p.(N297I) 0.198678499 9.67E-54 0.136363223 p.(N297L) 0.542182324 5.07E-32 0.494260972 p.(N297K) 0.290226014 2.78E-17 -0.461148591 p.(N297M) 0.121343932 7.35E-34 0.505619819 p.(N297F) 0.370183171 0.001154925 0.928190955 p.(N297P) 0.724265762 1.54E-38 -3.791613516 p.(N297S) 0.289480029 0.000982804 1.605472169 p.(N297T) 0.861253894 8.88E-16 0.241313662 p.(N297W) 0.546317007 5.81E-90 -0.697375109 p.(N297Y) 0.447795401 1.26E-87 -0.021879794 p.(N297V) 0.539358048 0 0.482695605 p.(N326A) 0.568839138 1.11E-16 0.827646133 p.(N326R) 0.382776307 1.02E-124 0.115043042 p.(N326D) 0.240324181 0 0.298741623 p.(N326C) 0.38928735 0.001367727 0.823302091 p.(N326Q) 0.534887561 8.40E-23 0.265910436 p.(N326E) 0.498509595 0 1.54596569 p.(N326G) 0.244426927 1.54E-69 0.915323481 p.(N326H) 0.478654342 3.56E-27 0.48420448 p.(N326I) 0.717176465 1.64E-23 -1.550290239 p.(N326L) 1.480589964 8.10E-118 -1.360943327 p.(N326K) 0.475062635 7.90E-74 -0.093451557 p.(N326M) 0.674279551 1.42E-59 -0.50183697 p.(N326F) 0.693436293 3.59E-12 -1.39447594 p.(N326P) 0.246299873 2.10E-49 -0.294104203 p.(N326S) 0.516558682 8.39E-23 0.419884154 p.(N326T) 0.556866418 4.79E-52 1.310720852 p.(N326W) 1.022607682 1.31E-23 -0.758059149 p.(N326Y) 0.668127098 6.58E-54 -0.202278345 p.(N326V) 0.849574986 8.70E-20 -1.214660441 p.(D294A) 0.324370426 4.52E-37 0.744356339 p.(D294R) 0.601804744 2.36E-21 0.362613779 p.(D294N) 0.384615035 1.11E-16 -0.54695006 p.(D294D) 0.33720772 0 -0.448323529 p.(D294C) 0.559267419 0.00147891 -0.303638369 p.(D294Q) 0.456292231 2.43E-35 0.601420041 p.(D294E) 0.151663258 2.68E-24 -0.348161434 p.(D294G) 0.594164389 1.09E-37 0.378026756 p.(D294H) 0.778005407 1.85E-30 -0.113179717 p.(D294I) 0.91069214 2.85E-90 -2.951064084 p.(D294L) 1.008918618 1.52E-54 -0.864680961 p.(D294K) 1.300763307 1.10E-27 -0.937016439 p.(D294M) 0.296552943 2.60E-30 -0.048279898 p.(D294F) 0.568686374 2.69E-10 -3.881444849 p.(D294P) 0.773063135 0 -4.100215552 p.(D294S) 0.284800017 4.45E-52 0.09901906 p.(D294T) 0.727067238 7.26E-48 -0.0766844 p.(D294W) 0.760591239 4.51E-27 -3.396017546 p.(D294Y) 0.511158403 2.61E-28 -2.655793656 p.(D294V) 0.830782029 3.09E-23 -1.708370888 p.(D296A) 0.632634447 1.67E-59 -0.07115844 p.(D296R) 0.868541199 5.97E-56 -0.553850603 p.(D296N) 0.442581984 2.28E-37 0.242477965 p.(D296D) 0.221304185 1.39E-17 0.419945863 p.(D296C) 0.79818704 4.89E-34 -0.330832645 p.(D296Q) 0.349575957 1.79E-15 0.457323727 p.(D296E) 0.135614536 5.33E-11 -0.238219381 p.(D296G) 0.431194069 1.81E-07 -0.23774178 p.(D296H) 0.088924983 1.63E-24 0.536125752 p.(D296I) 0.458618541 1.17E-40 -0.107785107 p.(D296L) 0.193483023 3.56E-25 -0.54142073 p.(D296K) 0.960652157 3.50E-118 -0.611070556 p.(D296M) 0.532299267 1.38E-66 0.257216321 p.(D296F) 0.362874366 1.40E-48 -0.052492 p.(D296P) 0.540770496 1.96E-75 0.017213276 p.(D296S) 0.306441199 5.53E-37 -0.236395639 p.(D296T) 0.426195803 1.95E-35 0.380137048 p.(D296W) 1.066841229 2.03E-41 -0.724080697 p.(D296Y) 0.605807904 1.14E-19 0.155193094 p.(D296V) 0.329320703 9.93E-40 0.429697246 p.(D299A) 0.294366506 4.04E-39 0.118423372 p.(D299R) 0.50160129 3.18E-16 -0.328407571 p.(D299N) 0.281915805 0 -1.037385049 p.(D299C) 0.329005605 2.97E-06 -0.514746624 p.(D299Q) 0.524408057 7.69E-08 0.04948494 p.(D299E) 0.301337848 3.02E-90 0.976160551 p.(D299G) 0.734477544 3.84E-146 -0.145582534 p.(D299H) 0.590575279 1.21E-45 0.245866929 p.(D299I) 0.811740834 7.87E-07 -0.578924715 p.(D299L) 0.460699817 1.12E-43 0.168696143 p.(D299K) 1.286260781 2.35E-23 -0.391413205 p.(D299M) 0.289232096 1.13E-07 0.119443487 p.(D299F) 0.837783082 7.21E-147 -0.229354865 p.(D299P) 0.974313737 1.56E-15 0.375704461 p.(D299S) 0.148832965 1.16E-31 -0.061999164 p.(D299T) 0.668373769 4.29E-15 0.007596334 p.(D299W) 0.584957214 1.66E-49 -0.112009473 p.(D299Y) 0.335984493 0 -0.904129153 p.(D299V) 0.502922642 2.38E-16 0.223598681 p.(C319A) 0.390578948 0.000360432 0.543310173 p.(C319R) 0.264570665 7.94E-56 -0.456805717 p.(C319N) 0.337562311 6.11E-18 0.952982464 p.(C319D) 0.33297657 6.09E-19 0.676340184 p.(C319C) 0.123516755 2.78E-17 -0.059268623 p.(C319Q) 0.334524528 3.96E-09 -0.225877773 p.(C319E) 0.715218154 6.33E-15 0.753717103 p.(C319G) 0.102511657 2.26E-07 -0.429744911 p.(C319H) 1.556040489 8.88E-16 2.345704238 p.(C319I) 0.434458231 8.95E-12 1.200096725 p.(C319L) 0.540817266 1.74E-54 0.366579478 p.(C319K) 0.309115471 1.09E-22 0.842896486 p.(C319M) 0.623292101 5.48E-37 0.043570474 p.(C319F) 0.605482082 0 1.703959723 p.(C319P) 1.813958946 8.88E-16 -4.185507087 p.(C319S) 0.462058494 1.11E-16 0.796479416 p.(C319T) 0.323209915 7.10E-12 1.390431053 p.(C319W) 0.691644507 4.44E-16 1.286566668 p.(C319Y) 0.603430857 6.99E-31 0.540944523 p.(C319V) 0.607370943 0 1.097572345 p.(Q293A) 0.424925871 5.55E-17 0.697271126 p.(Q293R) 0.287488014 1.85E-72 0.065236308 p.(Q293N) 0.346539373 2.78E-17 1.569313445 p.(Q293D) 0.159426288 1.74E-31 1.584427779 p.(Q293C) 0.348750054 2.48E-17 0.009476892 p.(Q293E) 0.800945001 0 1.432514373 p.(Q293G) 0.271396124 1.98E-30 1.370102145 p.(Q293H) 0.420101112 1.50E-45 0.216429397 p.(Q293I) 0.406081394 1.07E-58 0.418588847 p.(Q293L) 0.468946613 2.51E-55 1.033708207 p.(Q293K) 0.331522853 8.61E-28 -0.55887681 p.(Q293M) 0.364001039 2.04E-50 1.165415377 p.(Q293F) 0.394798005 2.16E-77 0.188145778 p.(Q293P) 0.306787126 2.21E-26 1.108478959 p.(Q293S) 0.334605784 9.41E-59 1.700520714 p.(Q293T) 0.257783929 0.000106272 0.997453243 p.(Q293W) 0.614441082 8.70E-108 0.209483491 p.(Q293Y) 0.764345848 2.59E-79 -0.236005203 p.(Q293V) 0.285320269 1.27E-102 1.03010752 p.(Q318A) 0.588573026 5.00E-42 0.43138066 p.(Q318R) 0.141558108 5.20E-17 -0.295977717 p.(Q318N) 0.38566798 3.17E-53 1.534821974 p.(Q318D) 0.672983791 1.17E-07 -0.159401519 p.(Q318C) 0.394141613 1.13E-08 0.835208615 p.(Q318Q) 0.391282875 0 0.196057274 p.(Q318E) 0.432546609 1.41E-92 0.118239074 p.(Q318G) 0.183678795 8.32E-27 -0.03878381 p.(Q318H) 0.673760399 8.87E-47 0.093096011 p.(Q318I) 0.579659164 1.27E-56 0.646806947 p.(Q318L) 0.269116039 1.39E-16 0.69211929 p.(Q318K) 0.143345232 3.82E-16 -0.840558817 p.(Q318M) 0.450872417 1.53E-41 1.340524464 p.(Q318F) 0.671959524 1.27E-30 1.099061688 p.(Q318P) 0.389286068 4.15E-08 0.157647299 p.(Q318S) 0.654871456 0.001222683 0.768886029 p.(Q318T) 0.703689831 1.73E-50 0.227638763 p.(Q318W) 0.675682652 4.31E-10 0.452415088 p.(Q318Y) 0.472982763 3.83E-16 0.49833486 p.(Q318V) 0.512833319 1.17E-43 0.427425536 p.(E301A) 1.059269685 4.64E-14 -3.113734157 p.(E301R) 0.232870551 4.09E-18 -4.422980485 p.(E301N) 0.444508982 1.88E-50 -3.282762708 p.(E301D) 0.20668563 6.00E-10 -2.966579899 p.(E301C) 2.122274732 0 -0.92727342 p.(E301Q) 0.77198541 5.83E-35 -1.111347874 p.(E301G) 0.337718869 2.98E-27 -3.347500543 p.(E301H) 0.330504705 2.82E-06 -4.544277245 p.(E301I) 0.988363431 0 -4.238875136 p.(E301L) 0.892099451 1.74E-12 -2.064121053 p.(E301K) 0.295215706 1.81E-23 -4.604509462 p.(E301M) 0.845443862 0 -3.320577583 p.(E301F) 0.582666202 0.0001306 -2.942619726 p.(E301P) 1.362983289 0 -2.973496122 p.(E301S) 0.975606876 4.95E-05 -2.954761387 p.(E301T) 0.775775473 0.007198184 -3.365531891 p.(E301W) 0.575609465 2.65E-09 -2.280314009 p.(E301Y) 0.828347401 8.73E-19 -3.379322345 p.(E301V) 0.752147685 6.66E-16 -4.323240501 p.(E307A) 0.534103464 7.94E-22 -0.22514878 p.(E307R) 0.752094972 4.96E-76 -0.169854265 p.(E307N) 0.655257822 2.22E-40 0.725935267 p.(E307D) 0.169010236 8.25E-08 1.07664198 p.(E307C) 0.157407847 6.73E-18 0.763400584 p.(E307Q) 0.632238384 1.97E-73 0.163867706 p.(E307E) 0.071732423 3.13E-80 -0.254897541 p.(E307G) 0.399855843 7.08E-15 0.178344751 p.(E307H) 0.606074609 2.50E-15 0.737936287 p.(E307I) 0.621548293 9.53E-94 -0.47277516 p.(E307L) 0.653432434 3.08E-86 0.217869743 p.(E307K) 0.06594826 2.99E-08 -0.95308088 p.(E307M) 0.567548762 1.25E-81 -0.549629992 p.(E307F) 0.76531628 7.95E-114 -0.398429353 p.(E307P) 0.79746074 1.15E-10 -3.044078362 p.(E307S) 0.487124351 6.70E-09 1.163494476 p.(E307T) 0.458698559 0.000215869 0.799738995 p.(E307W) 0.691712264 8.60E-07 -0.252253373 p.(E307Y) 0.789391003 5.01E-15 0.05599217 p.(E307V) 1.040894397 4.04E-12 -0.012087948 p.(E311A) 0.202314176 1.21E-89 1.378262215 p.(E311R) 0.374695107 6.15E-44 -0.729039938 p.(E311N) 0.369690361 2.29E-16 1.150823447 p.(E311D) 0.284038802 0 -0.313176826 p.(E311C) 0.323733694 8.47E-53 0.69397103 p.(E311Q) 0.318529454 1.36E-96 0.277675841 p.(E311E) 0.144097518 1.11E-11 -0.34600576 p.(E311G) 0.128396302 5.11E-14 -0.509208132 p.(E311H) 0.372990477 5.32E-19 0.887868915 p.(E311I) 0.467157015 3.74E-29 -0.00190131 p.(E311L) 0.586253069 1.64E-67 -0.226557142 p.(E311K) 0.549322765 2.19E-126 0.309448409 p.(E311M) 0.977398518 4.13E-20 -0.088475676 p.(E311F) 0.884957237 0.000553938 -0.408201531 p.(E311P) 0.192907834 1.20E-10 1.433616788 p.(E311S) 0.584219813 4.36E-31 0.266765909 p.(E311T) 0.449515929 2.17E-25 1.351311211 p.(E311W) 1.11685228 4.86E-36 -0.415785373 p.(E311Y) 0.412172863 0.004100037 1.03497113 p.(E311V) 0.45408859 0.002396726 0.314904394 p.(E327A) 0.754883804 1.83E-29 -3.657434303 p.(E327R) 0.718191066 3.98E-10 -3.940520262 p.(E327N) 0.953777119 0.014975692 -3.297236769 p.(E327D) 0.406613854 1.21E-82 0.627382751 p.(E327C) 0.3171204 3.66E-18 -4.182976977 p.(E327Q) 0.572195116 1.05E-22 -0.594125546 p.(E327E) 0.04884514 8.62E-33 -0.128055934 p.(E327G) 0.67892044 8.78E-67 -3.444860512 p.(E327H) 0.619845269 2.93E-06 -4.461433035 p.(E327I) 0.668440341 7.71E-09 -3.157593642 p.(E327L) 0.457101711 1.05E-28 -3.973558021 p.(E327K) 0.345244977 7.85E-12 -4.269905744 p.(E327M) 0.795467586 1.28E-10 -3.315172866 p.(E327F) 0.592489318 5.27E-26 -3.528448006 p.(E327P) 1.296156818 0 -3.304850841 p.(E327S) 0.481682834 3.41E-07 -4.250790717 p.(E327T) 1.164318474 4.44E-16 -4.336144343 p.(E327W) 0.865435933 1.99E-05 -2.563100017 p.(E327Y) 0.711474829 2.17E-106 -3.335615872 p.(E327V) 0.739611528 4.75E-06 -2.791205357 p.(E335A) 0.716517947 1.11E-39 -0.150375827 p.(E335R) 1.035210889 1.08E-10 -1.835779843 p.(E335N) 1.586226241 5.75E-75 -1.318416846 p.(E335D) 0.359123321 2.37E-19 0.356613781 p.(E335C) 0.617335176 8.66E-29 -0.238177378 p.(E335Q) 0.632532979 1.98E-72 -0.430191834 p.(E335G) 0.625421924 2.29E-22 -1.013800466 p.(E335H) 0.855666256 4.60E-49 -0.354410672 p.(E335I) 0.871868975 1.09E-12 -0.012625122 p.(E335L) 0.935010687 2.29E-94 0.080706692 p.(E335K) 0.347410073 1.56E-59 -0.885847352 p.(E335M) 0.956536289 2.67E-45 -0.214159397 p.(E335F) 0.897107705 2.98E-43 -0.727862217 p.(E335P) 1.130341128 2.66E-15 -3.168575754 p.(E335S) 0.544531767 1.50E-29 0.73497291 p.(E335T) 0.851633029 9.53E-35 -0.01138962 p.(E335W) 0.688654542 2.18E-10 -1.735189469 p.(E335Y) 1.164186613 1.51E-22 -1.211588042 p.(E335V) 0.715487629 2.51E-59 -0.298402345 p.(E340A) 1.108082082 1.29E-61 -0.348441113 p.(E340R) 0.946972029 1.99E-102 -0.387269377 p.(E340N) 0.604147945 9.99E-15 0.580546267 p.(E340D) 0.605195248 7.60E-68 0.332012506 p.(E340C) 0.527269242 6.27E-35 -0.023588631 p.(E340Q) 0.470618688 6.62E-32 -0.337292792 p.(E340E) 0.222894292 4.85E-14 -0.47807189 p.(E340G) 0.378970172 0 -0.307060015 p.(E340H) 0.806669181 5.07E-24 -0.351617698 p.(E340I) 0.527612306 1.70E-88 -0.160256677 p.(E340L) 0.412450851 2.92E-24 -0.040423273 p.(E340K) 0.216595059 5.52E-24 -0.638759725 p.(E340M) 0.56984274 1.63E-51 0.676927551 p.(E340F) 0.451976022 9.37E-18 0.830159941 p.(E340P) 0.622393518 4.09E-58 0.009128457 p.(E340S) 0.346790851 3.06E-71 0.623443706 p.(E340T) 0.753655828 1.18E-17 0.583718568 p.(E340W) 0.486707662 3.86E-48 0.370117102 p.(E340Y) 0.803747592 1.56E-69 -0.708491643 p.(E340V) 0.706974231 1.70E-51 0.09920918 p.(G308A) 0.610979926 2.13E-51 0.693122173 p.(G308R) 0.240999926 0 -0.67825158 p.(G308N) 0.256631113 2.36E-18 -0.475459892 p.(G308D) 0.937325689 6.75E-39 -0.497150633 p.(G308C) 0.63772247 6.15E-91 0.164042143 p.(G308Q) 0.415207561 1.62E-16 -0.244637322 p.(G308E) 0.229539187 1.03E-79 -0.123053885 p.(G308G) 0.141032592 9.75E-69 -0.234741245 p.(G308H) 0.418476909 2.65E-05 -0.553174911 p.(G308I) 0.61336908 1.09E-35 -0.167305773 p.(G308L) 0.448077826 2.28E-43 1.009712261 p.(G308K) 0.3879907 1.36E-21 0.454919065 p.(G308M) 0.479225611 2.32E-23 0.022022048 p.(G308F) 0.424490193 6.12E-07 0.118590085 p.(G308P) 0.296823284 7.49E-39 0.104886966 p.(G308S) 0.412864957 6.54E-83 0.496551702 p.(G308T) 0.663584235 1.09E-40 0.570579606 p.(G308W) 0.285906276 8.33E-17 -0.426964878 p.(G308Y) 0.648223688 4.11E-26 -0.272332581 p.(G308V) 0.587652207 7.58E-21 0.773870683 p.(G331A) 0.790457076 3.22E-41 -0.080416209 p.(G331R) 0.521772631 3.18E-40 -4.202388354 p.(G331N) 0.590771052 1.35E-31 -3.217042669 p.(G331D) 0.233749696 9.51E-26 -2.35080909 p.(G331C) 0.580948453 1.57E-07 -4.539662096 p.(G331Q) 1.314841247 2.22E-15 -2.207535984 p.(G331E) 0.795282664 2.22E-16 -4.222754244 p.(G331G) 0.079257933 3.71E-12 -0.378835326 p.(G331H) 0.97903137 6.66E-16 -4.191124397 p.(G331I) 0.465176736 1.85E-24 -3.200430615 p.(G331L) 0.646810962 5.23E-30 -3.318886126 p.(G331K) 0.750592615 1.12E-16 -2.40935566 p.(G331M) 1.858891127 2.66E-15 -1.905688532 p.(G331F) 0.167366365 0.000455072 -4.259370791 p.(G331P) 0.593912787 1.12E-27 -3.628300743 p.(G331S) 0.107028629 1.60E-26 -0.431358716 p.(G331T) 0.699148266 1.11E-16 -5.335859132 p.(G331W) 0.70187366 4.71E-13 -3.33269397 p.(G331Y) 0.827882972 0.000144695 -3.281576408 p.(G331V) 0.987347241 5.87E-57 -2.331079728 p.(H332A) 0.692235719 1.88E-14 0.413015174 p.(H332R) 0.774662342 1.85E-19 -0.252266375 p.(H332N) 0.997258195 2.87E-05 -1.427212814 p.(H332D) 0.836535326 1.21E-27 -2.218262813 p.(H332C) 0.582066755 4.34E-21 0.617921655 p.(H332Q) 0.150865776 1.59E-36 1.008741856 p.(H332E) 0.789320814 4.23E-31 -0.676789005 p.(H332G) 0.729304823 2.48E-05 -2.707726038 p.(H332H) 0.13771912 3.75E-13 0.187596781 p.(H332I) 0.51328124 1.33E-09 -3.470227545 p.(H332L) 0.714745404 0.000737374 -3.184296863 p.(H332K) 0.699811152 5.03E-96 -0.502963781 p.(H332M) 0.710895926 8.99E-87 -0.178909255 p.(H332F) 0.324860887 3.06E-70 0.613908513 p.(H332P) 0.371943331 7.57E-11 -4.204228053 p.(H332S) 0.182766785 2.20E-51 -0.684717551 p.(H332T) 0.833321997 2.78E-32 -3.104221894 p.(H332W) 0.532458881 7.81E-36 -0.385953154 p.(H332Y) 0.245101258 3.68E-33 0.406827441 p.(H332V) 1.415749175 4.40E-13 -3.495618697 p.(I295A) 0.814202954 1.35E-70 -0.057739487 p.(I295R) 1.10196843 0 -3.127041788 p.(I295N) 1.402288365 0 -3.302471483 p.(I295D) 1.137126325 1.33E-15 -5.013421568 p.(I295C) 0.343032807 2.27E-50 0.461949088 p.(I295Q) 0.978556144 2.27E-26 -3.285692502 p.(I295E) 1.126166991 4.44E-16 -4.692825332 p.(I295G) 1.024707708 3.94E-11 -4.674829543 p.(I295H) 0.586878197 2.46E-20 0.61392678 p.(I295I) 0.178872469 2.78E-17 -0.581634805 p.(I295L) 0.200531664 9.17E-22 1.522839857 p.(I295K) 1.429321817 6.84E-37 -0.870447393 p.(I295M) 0.160256022 1.46E-80 -0.540413907 p.(I295F) 0.331123361 8.33E-17 0.751933104 p.(I295P) 1.118254852 8.88E-16 -3.932309645 p.(I295S) 0.633723026 0.000199835 -4.062027636 p.(I295T) 0.864540234 3.97E-36 -0.034031595 p.(I295W) 0.460447827 5.41E-27 0.06694673 p.(I295Y) 0.621534302 3.21E-32 -1.077642847 p.(I295V) 0.576597033 1.26E-170 0.163600455 p.(I302A) 0.741159569 2.18E-12 -2.820268 p.(I302R) 1.008909329 1.03E-10 -2.597876005 p.(I302N) 0.581339656 1.14E-22 -3.732108503 p.(I302D) 0.784895191 6.52E-14 -3.415830764 p.(I302C) 1.037583861 1.80E-17 -3.228495623 p.(I302Q) 0.977143503 2.10E-25 -0.987228431 p.(I302E) 0.813888801 4.83E-13 -3.00703616 p.(I302G) 0.882849813 2.51E-43 -2.651111488 p.(I302H) 0.495062563 2.91E-59 -4.198401122 p.(I302L) 0.333924062 1.33E-49 0.72609171 p.(I302K) 0.684439786 0.001425583 -4.183230592 p.(I302M) 1.084130574 5.83E-61 -0.659899906 p.(I302F) 1.017923179 8.63E-58 -0.360457927 p.(I302P) 0.901971758 5.56E-32 -2.74838342 p.(I302S) 0.796790117 8.90E-14 -3.778720493 p.(I302T) 0.89880082 0.001398633 -2.37509853 p.(I302W) 0.616383608 5.86E-08 -5.245676808 p.(I302Y) 0.94179848 4.44E-16 -3.597857425 p.(I302V) 0.367981339 1.75E-08 0.655145672 p.(I305A) 0.249801334 6.25E-57 0.212060127 p.(I305R) 0.273043204 4.52E-07 0.616968807 p.(I305N) 0.342767636 5.69E-09 0.440325932 p.(I305D) 0.282277996 3.04E-77 -0.031115826 p.(I305C) 0.371796351 5.15E-11 1.477013202 p.(I305Q) 0.464213917 2.39E-69 1.024250794 p.(I305E) 0.664907143 1.78E-32 0.538765696 p.(I305G) 0.317195738 1.18E-07 -0.165146556 p.(I305H) 0.474263573 4.37E-23 0.135546983 p.(I305L) 0.6373068 4.29E-14 1.107961449 p.(I305K) 0.338502086 3.24E-71 0.835734291 p.(I305M) 0.139987507 1.05E-15 0.094443486 p.(I305F) 0.146496695 1.51E-27 0.904051929 p.(I305P) 0.546918435 1.18E-67 -4.503495216 p.(I305S) 0.437625485 3.76E-45 1.174054308 p.(I305T) 0.059742357 7.43E-82 0.196002037 p.(I305W) 0.267222948 1.96E-52 0.834417854 p.(I305Y) 0.493872272 5.13E-39 0.732304218 p.(I305V) 0.05613393 1.07E-19 1.076379287 p.(I328A) 0.362418295 7.64E-60 -3.790326386 p.(I328R) 0.531119079 8.88E-16 -3.961023292 p.(I328N) 0.500164664 3.20E-34 -3.418026599 p.(I328D) 0.559190816 6.92E-53 -4.357864035 p.(I328C) 0.906799974 2.43E-19 -1.024390396 p.(I328Q) 0.549298222 5.91E-14 -4.343073179 p.(I328E) 1.406567765 0 -3.938431072 p.(I328G) 0.725171297 5.04E-12 -4.31668615 p.(I328H) 1.068971196 1.56E-13 -2.337750681 p.(I328I) 0.243936382 2.78E-17 -0.307242647 p.(I328L) 0.425670348 3.18E-36 -0.101016428 p.(I328K) 0.438371645 0.000736579 -4.664608278 p.(I328M) 0.866397764 4.16E-105 -2.893908595 p.(I328F) 0.817875477 5.18E-31 -2.793380601 p.(I328P) 0.588808883 1.56E-13 -3.034669114 p.(I328S) 0.476606783 2.07E-24 -4.008526211 p.(I328T) 0.997742645 1.76E-08 -1.305024409 p.(I328W) 0.696232727 3.17E-12 -3.631293142 p.(I328Y) 0.771301251 3.95E-05 -3.345106501 p.(I328V) 0.562829847 1.20E-45 0.96832046 p.(L306A) 0.494894606 1.59E-67 0.61564933 p.(L306R) 0.679610529 1.17E-32 -3.430520047 p.(L306N) 0.708981116 2.85E-31 -2.379595541 p.(L306D) 0.615926562 8.90E-09 -4.411641872 p.(L306C) 0.152453929 1.40E-42 -0.582314338 p.(L306Q) 0.442840754 7.89E-27 -4.256570327 p.(L306E) 0.649035098 0.000167445 -4.648733802 p.(L306G) 0.911088459 2.65E-11 -0.273509442 p.(L306H) 1.292910679 3.63E-71 -1.687980227 p.(L306I) 0.504257704 1.57E-43 0.450996855 p.(L306L) 0.297126754 0 0.8273565 p.(L306K) 1.001510789 3.44E-10 -2.344907062 p.(L306M) 0.173392102 2.78E-17 -0.635986331 p.(L306F) 0.408978922 9.77E-50 0.732414748 p.(L306P) 0.279391867 5.82E-11 -2.554612094 p.(L306S) 0.760005702 1.33E-33 -2.843229359 p.(L306T) 0.70075602 5.70E-11 -0.290877577 p.(L306W) 0.601809319 3.33E-45 0.598446395 p.(L306Y) 0.467196286 1.71E-134 0.299109418 p.(L306V) 0.650909294 0 0.729726389 p.(L324A) 0.460132906 2.78E-16 1.643294047 p.(L324R) 0.140575664 0.000566049 1.150867653 p.(L324N) 0.400368078 1.06E-32 0.972735855 p.(L324D) 1.201659174 1.64E-40 -2.070576583 p.(L324C) 0.30095745 2.69E-66 0.767789313 p.(L324Q) 0.242986556 2.04E-21 0.721140003 p.(L324E) 0.821112489 2.55E-26 -1.065926518 p.(L324G) 0.425807704 1.08E-22 -0.732969433 p.(L324H) 0.225565511 4.37E-07 0.859432976 p.(L324I) 0.721128246 2.36E-75 0.33783069 p.(L324L) 0.693915015 0 0.571011783 p.(L324K) 0.55659072 2.33E-19 0.328691732 p.(L324M) 0.510853414 7.68E-18 0.164493519 p.(L324F) 0.076295915 6.16E-112 -0.325750502 p.(L324P) 0.722822154 0.00339407 -2.282821146 p.(L324S) 0.475814518 5.52E-35 0.23198413 p.(L324T) 0.275875847 1.31E-10 0.400562909 p.(L324W) 0.395797349 3.21E-67 0.065344757 p.(L324Y) 0.242462028 2.16E-47 0.447121493 p.(L324V) 0.451408259 8.04E-10 0.275911744 p.(L329A) 0.840884145 4.99E-160 -0.337902087 p.(L329R) 0.377070737 3.18E-83 0.268580528 p.(L329N) 0.508231244 4.64E-17 -0.517078514 p.(L329D) 1.110370809 2.53E-08 -2.350454398 p.(L329C) 0.854950367 1.33E-48 0.467915678 p.(L329Q) 0.610793933 1.66E-62 -0.288694037 p.(L329E) 0.950398515 1.02E-35 -0.161959437 p.(L329G) 1.366552045 4.44E-16 -3.698312569 p.(L329H) 0.098687648 2.03E-29 -0.281985938 p.(L329I) 0.372319659 0 0.714594783 p.(L329L) 0.615540264 1.11E-16 2.238587488 p.(L329K) 0.631658009 1.11E-16 0.473891468 p.(L329M) 0.295656525 5.65E-35 0.89139188 p.(L329F) 0.292116013 2.78E-17 -0.531132863 p.(L329P) 0.589606017 9.66E-11 -3.696359764 p.(L329S) 1.077057992 6.82E-63 -0.64712432 p.(L329T) 0.984554355 1.59E-29 -0.935166571 p.(L329W) 1.318683858 9.95E-33 -1.860544419 p.(L329Y) 1.300560167 4.45E-33 -0.259378538 p.(L329V) 0.346734286 0 0.948919594 p.(L338A) 0.712278489 0 1.379456136 p.(L338R) 0.41850266 4.09E-14 -3.501418447 p.(L338N) 0.91357626 2.90E-33 -0.951067569 p.(L338D) 0.69352356 3.48E-37 -1.0821662 p.(L338C) 0.436668485 0 1.995372468 p.(L338Q) 0.384135607 3.79E-10 0.31273852 p.(L338E) 0.577289663 1.73E-56 0.277918733 p.(L338G) 0.811423874 5.18E-51 -0.807922625 p.(L338H) 0.298353666 2.80E-88 1.150718972 p.(L338I) 0.38144811 0.001783446 1.58656727 p.(L338K) 0.854710358 1.08E-39 -2.042803131 p.(L338M) 0.289411694 2.22E-12 1.115250712 p.(L338F) 0.153321837 1.36E-21 -0.182477483 p.(L338P) 0.356732836 1.39E-20 -1.647579077 p.(L338S) 0.621095871 6.13E-47 -0.427508539 p.(L338T) 0.237338724 1.58E-93 1.46613443 p.(L338W) 0.503644673 5.20E-41 -0.135299862 p.(L338Y) 0.902887555 1.33E-15 1.410975419 p.(L338V) 0.295457611 0.00043133 1.414543927 p.(M309A) 0.552777137 1.11E-16 1.117801799 p.(M309R) 0.462185768 1.36E-06 1.094113043 p.(M309N) 0.394247194 5.74E-21 0.658345584 p.(M309D) 0.461630565 1.07E-16 -0.178464301 p.(M309C) 0.546933735 2.22E-16 1.545239502 p.(M309Q) 0.356825605 1.43E-48 0.15061843 p.(M309E) 0.794835255 0 1.367779227 p.(M309G) 0.442934063 5.05E-08 1.453423664 p.(M309H) 0.700850084 0 1.260187552 p.(M309I) 0.046046632 2.76E-61 -0.702377062 p.(M309L) 0.322365862 2.94E-14 0.07739056 p.(M309K) 0.403888465 2.30E-41 0.545195567 p.(M309F) 0.850955668 2.22E-16 1.77197344 p.(M309P) 0.146177202 1.82E-33 0.679300491 p.(M309S) 0.320263737 5.73E-24 1.043316045 p.(M309T) 0.31658628 1.96E-06 0.393953421 p.(M309W) 0.22636377 2.78E-17 1.752641051 p.(M309Y) 0.990156452 8.88E-16 2.022329805 p.(M309V) 0.327932749 7.84E-41 0.777820806 p.(M315A) 0.230321526 4.67E-42 -0.019219835 p.(M315R) 0.569710969 9.82E-30 0.367578463 p.(M315N) 0.440729102 6.06E-17 0.049208537 p.(M315D) 0.250110166 1.28E-18 0.79222159 p.(M315C) 0.760588634 0 1.32406 p.(M315Q) 0.753436603 0 0.931225426 p.(M315E) 0.59198858 8.88E-16 1.124451213 p.(M315G) 0.494018028 5.95E-10 0.322036104 p.(M315H) 0.65917583 2.01E-20 -0.334187886 p.(M315I) 0.168424775 1.11E-31 0.063885023 p.(M315L) 0.564405276 5.55E-17 0.440868777 p.(M315K) 0.453223264 1.30E-62 0.181379793 p.(M315F) 0.146143356 9.62E-20 -0.071204757 p.(M315P) 0.475742977 1.28E-42 0.793650059 p.(M315S) 0.677146434 2.69E-13 0.332840157 p.(M315T) 0.420678601 2.09E-31 0.891243621 p.(M315W) 0.747192526 0 0.338825908 p.(M315Y) 0.635245148 4.64E-33 0.312129655 p.(M315V) 0.740030152 3.03E-104 0.168359898 p.(F300A) 0.906167357 2.22E-16 -4.267451893 p.(F300R) 0.920846468 9.10E-15 -4.020976916 p.(F300N) 1.027215945 8.88E-16 -4.478691579 p.(F300D) 0.731542026 5.91E-10 -5.152183034 p.(F300C) 1.186027545 1.15E-14 -2.137365294 p.(F300Q) 0.574654217 4.68E-19 -3.730422056 p.(F300E) 1.140353874 4.44E-16 -3.427751563 p.(F300G) 0.540343771 1.31E-20 -4.258512685 p.(F300H) 0.545014608 8.84E-35 -3.273781239 p.(F300I) 1.073063304 4.48E-87 -0.163302776 p.(F300L) 0.69443181 8.21E-44 -1.22745593 p.(F300K) 0.665942328 7.72E-11 -3.61018163 p.(F300M) 1.035641821 6.82E-118 -0.124666148 p.(F300F) 0.023876968 6.79E-15 -0.43934654 p.(F300P) 0.665146266 8.75E-11 -4.074862956 p.(F300S) 0.695712975 2.11E-65 -2.111935714 p.(F300T) 1.172470542 0 -3.451523135 p.(F300W) 0.491368401 1.27E-49 0.789545816 p.(F300Y) 0.349009251 4.38E-42 -4.212619016 p.(F300V) 1.065458885 9.85E-21 -2.244776462 p.(F339A) 0.65939126 8.38E-10 1.822013275 p.(F339R) 0.285290975 3.78E-154 1.251919382 p.(F339N) 1.322638907 0 3.252071079 p.(F339D) 0.62225937 1.11E-16 1.9624184 p.(F339C) 0.391280649 5.40E-07 1.053480017 p.(F339Q) 0.896401542 4.44E-16 3.428043264 p.(F339E) 0.60981449 9.75E-11 2.148633604 p.(F339G) 0.498755827 5.07E-17 0.922176011 p.(F339H) 0.377936741 0 2.307733558 p.(F339I) 1.194238387 0 2.460983785 p.(F339L) 0.277050974 1.16E-86 2.14117638 p.(F339K) 0.348749192 1.27E-05 1.049382711 p.(F339M) 0.893281748 0 2.66413625 p.(F339F) 0.184330598 1.39E-17 -0.050323698 p.(F339P) 0.652151902 9.58E-18 -2.186230747 p.(F339S) 0.234094852 1.87E-57 0.318526134 p.(F339T) 0.682237897 0 2.483779945 p.(F339W) 0.57968004 0 0.793616294 p.(F339Y) 0.105170932 0 1.821945179 p.(F339V) 0.423461759 3.39E-80 0.689627544 p.(P336A) 0.738155902 0 2.525177289 p.(P336R) 0.431713691 1.72E-14 0.304841806 p.(P336N) 0.638284789 3.33E-16 2.245136615 p.(P336D) 0.455075491 1.77E-22 2.788584009 p.(P336C) 0.364976009 2.82E-50 0.704235718 p.(P336Q) 0.167046483 3.19E-25 1.724808754 p.(P336E) 0.558949452 1.47E-34 1.760881175 p.(P336G) 0.283759688 6.27E-42 0.795485041 p.(P336H) 0.40093853 1.11E-16 2.08402908 p.(P336I) 0.657590741 1.97E-93 -0.141400007 p.(P336L) 1.020292803 8.64E-16 -0.861982373 p.(P336K) 0.513339393 0 2.047291012 p.(P336M) 0.709560911 4.51E-41 0.131771632 p.(P336F) 0.850679626 1.82E-06 -2.713123604 p.(P336P) 0.095612537 0 -0.434836899 p.(P336S) 0.655983213 0 2.512227233 p.(P336T) 0.265199407 9.65E-43 0.062698109 p.(P336W) 1.174384601 1.15E-10 -0.233578953 p.(P336Y) 0.652970405 9.52E-25 0.539610139 p.(P336V) 0.642624815 2.99E-05 0.368817295 p.(S321A) 0.417771258 5.55E-17 1.311911919 p.(S321R) 0.492169548 1.32E-07 0.521540961 p.(S321N) 0.117512044 1.57E-22 -0.013400952 p.(S321D) 2.451832145 3.55E-15 -2.741804961 p.(S321C) 0.873431327 0 1.750237015 p.(S321Q) 1.460342223 0 2.646093956 p.(S321E) 0.454158118 5.37E-05 -0.453890863 p.(S321G) 1.429913089 8.88E-16 1.322970205 p.(S321H) 0.694192621 6.66E-16 1.637435057 p.(S321I) 0.264552411 2.78E-17 1.014812525 p.(S321L) 0.667092135 5.31E-31 -1.81861327 p.(S321K) 0.464988097 2.97E-08 1.095809642 p.(S321M) 0.764230702 0 1.723531935 p.(S321F) 0.621569284 1.11E-16 1.93962739 p.(S321P) 0.809744461 4.19E-09 -4.138723636 p.(S321S) 0.396713961 7.56E-12 1.254069038 p.(S321T) 0.525040031 1.18E-31 0.733378141 p.(S321W) 0.62897721 0.006849138 0.877313867 p.(S321Y) 0.321089411 1.75E-06 2.18965361 p.(S321V) 0.512604956 0 1.343255539 p.(S322A) 0.790705293 3.11E-19 -1.050887028 p.(S322R) 0.480307361 1.47E-17 -3.907509272 p.(S322N) 0.641583222 5.82E-68 -3.788328218 p.(S322D) 1.078798041 2.89E-107 -2.192204922 p.(S322C) 0.730727948 6.37E-46 -1.385490988 p.(S322Q) 0.59158437 9.90E-55 -4.717538052 p.(S322E) 0.931927582 9.68E-65 -2.669878659 p.(S322G) 1.058552397 3.05E-26 -0.700579335 p.(S322H) 0.748710225 0 -3.328926202 p.(S322I) 0.681067614 2.80E-17 -2.977426729 p.(S322L) 0.684229203 1.67E-11 -3.766486805 p.(S322K) 0.658368839 3.81E-07 -3.114151467 p.(S322M) 0.299197587 2.18E-11 -4.656295897 p.(S322F) 0.551094659 1.89E-31 -4.648764286 p.(S322P) 0.834538248 1.63E-07 -4.606528113 p.(S322S) 0.241737131 6.67E-41 0.577469356 p.(S322T) 0.528309922 1.72E-37 -0.635512999 p.(S322W) 0.899180644 2.12E-09 -3.041381301 p.(S322Y) 0.640085176 4.52E-32 -3.551986864 p.(S322V) 0.566289931 2.11E-99 -3.831501002 p.(T313A) 0.123321591 2.38E-84 0.308678692 p.(T313R) 0.523724003 8.16E-38 0.373605838 p.(T313N) 0.028936617 1.11E-23 0.127043121 p.(T313D) 0.716872928 0 1.387995915 p.(T313C) 0.229251184 1.03E-43 0.612507362 p.(T313Q) 0.494824669 1.11E-16 0.796180611 p.(T313E) 0.718055359 2.22E-16 1.006372904 p.(T313G) 0.364908726 3.21E-36 0.848105039 p.(T313H) 0.505983004 0 0.449762411 p.(T313I) 0.416824199 5.55E-17 -0.594065539 p.(T313L) 0.372282533 1.02E-23 0.567085163 p.(T313K) 0.54682244 2.55E-40 0.025119266 p.(T313M) 0.340354511 4.13E-27 0.821894196 p.(T313F) 0.626364413 1.11E-16 0.027776968 p.(T313P) 0.338962439 1.21E-08 0.745992749 p.(T313S) 0.381432582 0 0.34591075 p.(T313W) 0.46620876 2.84E-29 0.722791937 p.(T313Y) 0.481601585 0.000165354 -0.017224461 p.(T313V) 0.765772305 2.71E-42 0.434246381 p.(T316A) 0.40905041 2.35E-15 1.070105466 p.(T316R) 0.820255567 6.97E-21 0.213736842 p.(T316N) 0.57355416 4.46E-25 1.283889331 p.(T316D) 0.428718896 3.78E-42 0.729171924 p.(T316C) 0.677130634 2.22E-16 1.408091704 p.(T316Q) 0.487264026 5.11E-58 0.495813216 p.(T316E) 0.634325734 1.91E-37 2.990800587 p.(T316G) 0.479515555 5.63E-18 0.532967909 p.(T316H) 0.746846248 2.22E-16 1.379321599 p.(T316I) 0.112848482 1.50E-05 -0.135701092 p.(T316L) 0.686474435 0 2.081392559 p.(T316K) 0.433266455 0 -0.155521056 p.(T316M) 0.922381948 0 1.469108302 p.(T316F) 0.492470761 5.55E-06 0.280077228 p.(T316P) 0.469713151 1.67E-16 0.32101264 p.(T316S) 0.493429589 1.11E-16 1.023366 p.(T316W) 0.487357155 7.64E-14 1.27136307 p.(T316Y) 0.583689831 3.33E-16 0.814118845 p.(T316V) 0.450957015 0 1.442591703 p.(T317A) 0.53196241 9.31E-50 1.095573546 p.(T317R) 0.844032218 3.85E-12 1.404771196 p.(T317N) 0.473200713 2.08E-15 0.209081946 p.(T317D) 0.486232308 1.22E-49 0.35926969 p.(T317C) 0.523303321 0 1.810691623 p.(T317Q) 0.292277137 1.93E-38 0.423008931 p.(T317E) 0.543054538 1.11E-16 1.283843286 p.(T317G) 0.606275974 1.48E-63 0.373894883 p.(T317H) 0.348852359 8.33E-17 1.224893112 p.(T317I) 0.077321372 6.27E-47 -0.214738839 p.(T317L) 0.363037659 1.02E-55 0.471105631 p.(T317K) 0.551545056 8.99E-42 -0.321164838 p.(T317M) 0.503743243 0 1.2356609 p.(T317F) 0.668827138 0 2.514529633 p.(T317P) 1.016815149 1.15E-10 -0.719070636 p.(T317S) 0.598539583 6.36E-50 0.450750565 p.(T317T) 0.054280997 9.19E-12 -0.087007014 p.(T317W) 0.564882537 0 0.878424484 p.(T317Y) 0.512793621 1.57E-60 0.875822882 p.(T317V) 0.57874542 3.02E-10 1.701767709 p.(W330A) 0.565382803 3.63E-23 -3.875773893 p.(W330R) 0.3182504 3.43E-40 -4.279545518 p.(W330N) 0.947672452 6.50E-54 -1.918639489 p.(W330D) 0.758379581 6.93E-26 -3.604155253 p.(W330C) 0.321853618 2.50E-50 -2.639264733 p.(W330Q) 1.315145137 0 -3.724743931 p.(W330E) 1.14067481 0 -3.736091311 p.(W330G) 0.625043032 4.33E-92 -3.975568006 p.(W330H) 0.782272558 9.62E-05 -2.529021085 p.(W330I) 0.890191925 1.29E-65 -3.048934651 p.(W330L) 0.780159741 1.82E-140 -3.616123029 p.(W330K) 1.493868221 8.88E-16 -3.541670154 p.(W330M) 0.626525618 4.64E-24 -3.861746575 p.(W330F) 0.760306614 1.54E-35 -3.395803672 p.(W330P) 1.422605055 0 -2.7688584 p.(W330S) 0.717803971 4.44E-12 -3.167127067 p.(W330T) 0.697226258 9.19E-12 -4.095774702 p.(W330Y) 0.931527275 7.17E-05 -3.765849461 p.(W330V) 0.271693331 0.000589801 -5.7037077 p.(Y323A) 0.652266304 4.51E-21 -3.864175585 p.(Y323R) 0.808208611 3.34E-08 -3.288324255 p.(Y323N) 0.724853837 2.38E-52 -3.876431776 p.(Y323D) 0.91914011 1.34E-06 -1.96687998 p.(Y323C) 0.537943209 9.21E-13 -0.183842878 p.(Y323Q) 1.150191108 0 -2.945375804 p.(Y323E) 0.60100386 1.16E-07 -4.183831835 p.(Y323G) 0.966502931 0 -3.630603659 p.(Y323H) 0.949171773 1.65E-15 -3.004287689 p.(Y323I) 0.82058679 3.27E-13 0.261603296 p.(Y323L) 0.631308233 9.83E-44 0.796571021 p.(Y323K) 0.438012043 2.20E-34 -4.372307552 p.(Y323M) 0.658960589 2.02E-32 0.370716997 p.(Y323F) 0.552872185 1.88E-23 0.547256093 p.(Y323P) 0.45454089 3.45E-21 -4.320872781 p.(Y323S) 0.619548237 2.47E-34 -2.781723631 p.(Y323T) 0.491710215 8.27E-20 -0.059248416 p.(Y323W) 0.66190716 3.94E-75 0.371412666 p.(Y323V) 0.619773293 4.08E-20 0.133446934 p.(Y334A) 1.123526996 0 -2.559155993 p.(Y334R) 0.758592608 5.30E-22 -3.354443606 p.(Y334N) 1.421044693 0 -2.825659111 p.(Y334D) 0.737195109 5.68E-10 -3.595419807 p.(Y334C) 1.410127299 3.81E-17 -2.49677685 p.(Y334Q) 0.687896135 2.15E-06 -3.941112489 p.(Y334E) 0.639406469 9.62E-09 -3.97208229 p.(Y334G) 1.435584343 8.88E-16 -2.642925346 p.(Y334H) 0.218172519 1.30E-14 -0.316166635 p.(Y334I) 1.22914082 1.36E-20 -2.380774099 p.(Y334L) 0.267858647 3.36E-13 -0.76157469 p.(Y334K) 0.867546289 1.17E-08 -3.90267618 p.(Y334M) 0.594738087 4.63E-51 -0.727065075 p.(Y334F) 0.519084267 1.17E-103 0.107079415 p.(Y334P) 0.873617309 1.94E-25 -1.095196685 p.(Y334S) 1.207469134 0 -3.901779577 p.(Y334T) 0.682775342 6.49E-08 -3.73858404 p.(Y334W) 0.370240533 4.86E-58 0.143467688 p.(Y334V) 1.031464302 0.00108774 -1.189515697 p.(V303A) 0.235257865 4.29E-77 0.518062484 p.(V303R) 0.797340872 9.87E-08 -2.362679574 p.(V303N) 0.575041073 6.29E-52 -2.265381662 p.(V303D) 0.786431576 1.98E-35 -1.126724675 p.(V303C) 0.580747526 6.83E-54 0.223607263 p.(V303Q) 0.72489224 7.71E-42 -0.319131723 p.(V303E) 0.533488921 9.93E-88 -1.693397003 p.(V303G) 0.312162748 2.15E-05 -2.074840269 p.(V303H) 0.14780975 0.000325994 1.347417708 p.(V303I) 1.027855045 4.44E-16 0.967074615 p.(V303L) 0.418519272 2.36E-15 0.854019751 p.(V303K) 0.621648291 3.46E-17 -3.544491719 p.(V303M) 0.403103267 1.67E-36 0.628415528 p.(V303F) 1.018050369 1.38E-40 0.095748779 p.(V303P) 0.60980686 2.57E-13 -4.05013212 p.(V303S) 0.683915182 1.74E-32 -0.572064782 p.(V303T) 0.319107709 2.63E-40 1.036269824 p.(V303W) 1.742220671 1.33E-15 -3.60154002 p.(V303Y) 0.724638229 3.49E-109 -0.045913589 p.(V303V) 0.139717892 2.51E-22 -0.271693891 p.(V304A) 0.428223503 5.33E-49 0.209853714 p.(V304R) 0.543150943 8.55E-22 -4.185742597 p.(V304N) 0.800454193 1.23E-25 -1.767499859 p.(V304D) 0.64129002 1.55E-15 -4.162408572 p.(V304C) 0.696798399 0 0.690193192 p.(V304Q) 0.724108081 2.75E-14 -4.165329994 p.(V304E) 1.002481297 4.64E-10 -3.878359642 p.(V304G) 0.923433854 5.60E-46 -1.551675451 p.(V304H) 1.18904602 0.000485502 -2.488265054 p.(V304I) 0.400760328 4.61E-19 1.689455039 p.(V304L) 0.802438602 0 1.034167992 p.(V304K) 0.878373256 0 -4.118041245 p.(V304M) 0.476549227 1.71E-34 0.196487374 p.(V304F) 0.084779423 2.13E-37 -0.592321083 p.(V304P) 1.503318193 1.15E-66 -2.334703319 p.(V304S) 0.281208516 0.001899007 1.536059515 p.(V304T) 0.56350673 1.24E-52 0.448082556 p.(V304W) 0.514917476 7.35E-72 0.200580969 p.(V304Y) 0.552009403 9.39E-83 -0.383710349 p.(V304V) 0.06887569 8.96E-37 -0.085832901 p.(V310A) 0.084633376 7.83E-09 -0.252375158 p.(V310R) 0.405472051 5.34E-57 0.639549249 p.(V310N) 0.746188712 0 1.046485154 p.(V310D) 0.422421686 0 1.596520694 p.(V310C) 0.566787887 0.000162415 0.987000275 p.(V310Q) 0.79401476 0 1.174319607 p.(V310E) 0.689756893 6.66E-16 1.119663074 p.(V310G) 1.528605623 8.88E-16 2.774540881 p.(V310H) 0.386909414 2.42E-10 0.91344224 p.(V310I) 0.60798456 3.09E-10 1.297687161 p.(V310L) 0.209963413 1.39E-17 0.201320315 p.(V310K) 0.09190195 6.32E-38 -0.346243231 p.(V310M) 0.620360007 3.78E-10 0.910876544 p.(V310F) 0.22452335 4.63E-20 -0.348210588 p.(V310P) 0.399765965 0 0.81009043 p.(V310S) 0.991716716 2.22E-16 1.399711486 p.(V310T) 0.521275255 1.99E-11 1.585964721 p.(V310W) 0.500170624 1.27E-45 0.482075888 p.(V310Y) 0.464722986 3.08E-05 0.499499576 p.(V337A) 0.399146104 5.70E-21 0.868451334 p.(V337R) 0.672763357 0.000490579 -4.348112064 p.(V337N) 1.001208877 2.97E-21 -0.646191328 p.(V337D) 0.74722474 2.45E-59 -1.33254828 p.(V337C) 0.851494028 0 0.676299613 p.(V337Q) 0.425277747 1.62E-14 -3.918157668 p.(V337E) 1.048988213 0.002627174 -1.804726113 p.(V337G) 1.053315176 1.53E-22 -2.691301613 p.(V337H) 0.443675534 3.97E-22 -3.332982601 p.(V337I) 0.295778807 1.43E-13 0.737330007 p.(V337L) 0.205405674 3.59E-11 0.775069268 p.(V337K) 0.697233733 7.83E-23 -1.619010033 p.(V337M) 0.179857527 1.02E-118 0.973670941 p.(V337F) 0.29212683 0 -0.055940717 p.(V337P) 3.155447431 0 -3.085805244 p.(V337S) 0.671542633 8.73E-13 -0.141546648 p.(V337T) 0.139040915 0.000299073 0.825717168 p.(V337W) 0.468642998 7.22E-08 -1.861535735 p.(V337Y) 0.659578153 3.66E-74 0.160084659 p.(V337V) 0.222500715 1.39E-17 -0.448289528 p.(A366A) 0.093090235 0.000144462 -0.1211669 p.(A366R) 1.024377937 1.18E-08 -3.260726217 p.(A366N) 1.114990038 8.88E-16 -3.121978987 p.(A366D) 0.93722994 5.87E-06 -3.283012282 p.(A366C) 1.04962287 3.29E-06 -2.774673087 p.(A366Q) 1.116467924 2.81E-54 -0.131860502 p.(A366E) 0.481326431 1.45E-20 -4.747357933 p.(A366G) 0.754442285 1.21E-78 0.122952129 p.(A366H) 0.557015116 5.85E-25 -4.05433223 p.(A366I) 1.176693965 6.07E-11 -1.912103873 p.(A366L) 0.648753685 8.28E-28 -3.74594626 p.(A366K) 0.629368486 6.23E-06 -3.045505676 p.(A366M) 0.333350782 2.07E-23 0.198697779 p.(A366F) 0.652996231 0.002355931 -3.710283885 p.(A366P) 0.653514639 6.09E-71 -0.889208719 p.(A366S) 0.594774221 2.44E-26 0.51415203 p.(A366T) 0.257264049 1.06E-14 -2.597378226 p.(A366W) 0.658910293 2.41E-23 -3.216718031 p.(A366Y) 0.623915052 0.000648717 -2.674801971 p.(A366V) 0.732433895 3.06E-18 -3.811674397 p.(A370R) 0.626718948 2.92E-32 0.833246073 p.(A370N) 0.437108962 5.02E-23 0.152176261 p.(A370D) 0.481266566 2.34E-84 0.228680565 p.(A370C) 0.679985501 1.75E-82 0.199840151 p.(A370Q) 0.423794302 0.00022632 0.447887895 p.(A370E) 0.132504968 4.07E-05 -1.286923432 p.(A370G) 0.564057574 9.54E-57 -0.844649323 p.(A370H) 0.621616137 6.07E-39 0.149037447 p.(A370I) 0.433073869 7.79E-49 0.406679765 p.(A370L) 0.766177128 2.35E-21 -0.028518745 p.(A370K) 0.421531777 4.88E-22 1.669287714 p.(A370M) 0.557414288 7.54E-78 0.133846285 p.(A370F) 0.064528591 1.05E-79 -0.303542012 p.(A370P) 0.490552081 8.98E-37 -1.134225877 p.(A370S) 0.316076496 8.33E-17 -0.634329975 p.(A370T) 0.52885188 2.27E-12 0.267784642 p.(A370W) 0.730479542 2.23E-60 -0.310384559 p.(A370Y) 0.626821681 5.22E-50 -0.197157881 p.(A370V) 0.368603198 1.91E-10 1.174506441 p.(A379A) 0.356398425 2.71E-24 0.754479592 p.(A379R) 0.138301097 6.25E-94 0.730890724 p.(A379N) 0.202334869 5.86E-22 0.298953019 p.(A379D) 0.769622123 2.22E-16 1.241305767 p.(A379C) 0.472269172 7.10E-10 0.452753617 p.(A379Q) 0.450496286 1.72E-15 1.438514367 p.(A379E) 0.056187652 4.77E-36 0.265194107 p.(A379G) 0.199314272 2.54E-11 0.832067272 p.(A379H) 0.363333315 3.87E-112 0.713086375 p.(A379I) 0.025562528 2.37E-20 -0.526168545 p.(A379L) 0.492820784 9.01E-76 0.398370349 p.(A379K) 0.746296971 6.66E-32 -0.682312638 p.(A379M) 0.738412807 1.21E-51 0.213970472 p.(A379F) 0.49599279 2.33E-54 -0.845681691 p.(A379P) 0.394418197 1.68E-86 0.618760358 p.(A379S) 0.42870336 0.002112043 2.172248319 p.(A379T) 0.427755706 3.30E-24 1.379539871 p.(A379W) 0.641598511 1.26E-71 -0.366613604 p.(A379Y) 0.483509248 2.09E-87 -0.045421115 p.(A379V) 0.463958221 1.11E-62 0.459310613 p.(R351A) 0.341603951 7.21E-21 2.212254204 p.(R351N) 0.614697831 3.00E-06 2.987356903 p.(R351D) 0.443326497 9.44E-27 -0.551261107 p.(R351C) 0.30684503 4.47E-15 2.161376744 p.(R351Q) 0.466095096 3.57E-08 2.523919975 p.(R351E) 1.189076676 0 4.888689183 p.(R351G) 1.022848994 0 3.144451445 p.(R351H) 1.079474792 0 2.935175153 p.(R351I) 0.96951504 0 2.91492613 p.(R351L) 0.401707769 0 2.393769556 p.(R351K) 0.133448709 1.04E-17 0.678973321 p.(R351M) 0.252368981 3.73E-20 -0.090168385 p.(R351F) 0.291576487 3.04E-15 0.977490751 p.(R351P) 0.61138378 1.48E-10 -0.142974089 p.(R351S) 0.399632769 1.47E-16 3.791731824 p.(R351T) 1.182398727 0 5.317687309 p.(R351W) 0.390475991 1.52E-32 1.079036589 p.(R351Y) 0.528994625 3.00E-15 1.502416315 p.(R351V) 0.640612712 0 1.938495203 p.(R367A) 0.619329561 1.38E-71 -0.750973332 p.(R367R) 0.335987835 7.55E-23 0.927244782 p.(R367N) 1.139713642 1.38E-05 -2.616439433 p.(R367D) 0.349989961 3.40E-34 -4.640753953 p.(R367C) 0.683860388 3.05E-19 -1.560178748 p.(R367Q) 0.826911366 3.23E-08 -1.46288864 p.(R367E) 1.227735369 0 -2.952638795 p.(R367G) 0.552530206 2.42E-09 -4.179470205 p.(R367H) 0.263728964 9.88E-30 0.866823818 p.(R367I) 0.316834366 2.33E-13 -4.076330458 p.(R367L) 0.702368345 3.87E-72 -2.341796927 p.(R367K) 0.656013165 2.22E-16 2.262893866 p.(R367M) 1.326419019 3.55E-15 -2.653839413 p.(R367F) 0.581610769 3.44E-06 -3.715948879 p.(R367P) 0.804648444 1.06E-06 -4.234656384 p.(R367S) 0.752859832 0.00020474 -1.085895091 p.(R367T) 0.638940634 3.97E-09 -3.215917459 p.(R367W) 0.306808504 6.91E-39 -2.774059599 p.(R367Y) 0.633264369 5.82E-58 -3.339094608 p.(R367V) 1.040031422 2.88E-39 -1.994811462 p.(N360A) 0.189808294 7.62E-35 0.809576445 p.(N360R) 0.419393115 7.30E-77 0.135858091 p.(N360D) 0.273441306 9.49E-24 0.906634821 p.(N360C) 0.784115443 2.19E-29 0.204739259 p.(N360Q) 0.241223848 1.25E-37 0.819166148 p.(N360E) 0.474520901 1.56E-15 2.666943331 p.(N360G) 0.401094782 8.17E-24 0.908299739 p.(N360H) 0.423621624 6.32E-19 1.873969687 p.(N360I) 0.167878906 2.45E-56 -0.915464196 p.(N360L) 0.370226263 3.16E-97 -0.306216574 p.(N360K) 0.218030933 0.00015794 -1.300283176 p.(N360M) 0.498317558 1.11E-16 1.012311919 p.(N360F) 0.454203221 5.07E-07 0.329175926 p.(N360P) 1.978471931 0 -4.236687522 p.(N360S) 0.260275468 2.62E-06 -0.107575371 p.(N360T) 0.325571344 2.50E-16 1.208881529 p.(N360W) 0.460198342 3.94E-15 0.491692578 p.(N360Y) 0.859023816 5.08E-61 0.011187494 p.(N360V) 1.128166311 1.15E-77 -0.734434328 p.(N378A) 0.323044491 4.96E-09 0.262802734 p.(N378R) 0.492556019 2.48E-79 1.887178048 p.(N378D) 0.210242557 3.44E-36 0.400792039 p.(N378C) 0.477956237 8.62E-53 0.040707048 p.(N378Q) 0.198561393 1.63E-29 0.420843647 p.(N378E) 0.299616785 0.00022328 1.527553198 p.(N378G) 0.616383098 0 1.097740802 p.(N378H) 0.397825492 7.15E-26 0.988586667 p.(N378I) 0.816539831 1.13E-09 -1.023452912 p.(N378L) 0.877487995 5.10E-33 -0.445640448 p.(N378K) 0.685929741 1.77E-78 0.337763982 p.(N378M) 1.174678647 6.58E-22 0.061375399 p.(N378F) 0.783050196 1.70E-44 -0.428762488 p.(N378P) 0.559005981 3.75E-53 1.357459966 p.(N378S) 0.65264914 2.22E-16 0.978955963 p.(N378T) 0.244921777 1.68E-21 0.436402743 p.(N378W) 0.801695013 1.20E-28 -1.249248547 p.(N378Y) 0.919506254 2.61E-136 -0.502086855 p.(N378V) 0.708126772 6.96E-136 0.223810772 p.(N380A) 0.387600487 1.97E-34 0.139895273 p.(N380R) 0.164779068 4.23E-15 0.378382397 p.(N380N) 0.200408319 9.40E-16 -0.845734728 p.(N380D) 0.216375093 2.72E-11 0.635509666 p.(N380C) 0.718536496 1.19E-09 0.547853188 p.(N380Q) 0.422611541 4.47E-93 -0.258596579 p.(N380E) 0.2543246 1.45E-17 1.412435525 p.(N380G) 0.379836583 1.80E-42 0.200903942 p.(N380H) 0.483530307 7.06E-62 0.41949377 p.(N380I) 0.515842923 1.88E-50 -0.397457742 p.(N380L) 1.06169164 2.79E-17 -0.804727093 p.(N380K) 0.216285927 3.58E-16 -0.691092681 p.(N380M) 0.453511571 0.002246045 -0.04236536 p.(N380F) 0.469375853 8.95E-34 -0.133869747 p.(N380P) 0.510225214 0 0.465854976 p.(N380S) 0.727822804 0 0.978386624 p.(N380T) 0.125638779 1.08E-46 0.443407584 p.(N380W) 0.752190077 2.42E-07 -1.034471606 p.(N380Y) 0.63741704 1.94E-74 -0.454827756 p.(N380V) 0.345539943 2.89E-49 -0.047381239 p.(N386A) 0.316497906 0.000134973 1.569400118 p.(N386R) 0.234930465 1.04E-51 0.768323192 p.(N386D) 0.371596002 3.61E-74 1.29244945 p.(N386C) 0.668477682 5.72E-116 0.280624794 p.(N386Q) 0.475403413 1.80E-38 1.197295252 p.(N386E) 0.979860852 8.88E-16 3.486511518 p.(N386G) 0.292977951 0 0.748851846 p.(N386H) 0.62147822 1.11E-16 0.651649842 p.(N386I) 0.883710296 1.60E-111 -0.84249917 p.(N386L) 1.04962763 4.24E-46 -1.492479671 p.(N386K) 0.156851401 6.57E-51 -0.043565812 p.(N386M) 0.676760166 1.20E-111 -0.307937048 p.(N386F) 0.935876211 1.68E-69 -0.33484965 p.(N386P) 0.612849085 1.40E-25 -0.489032128 p.(N386S) 0.569479391 0 3.657839005 p.(N386T) 0.624190626 3.62E-14 1.045608118 p.(N386W) 0.842531297 4.67E-59 -0.805862557 p.(N386Y) 0.354483443 1.05E-75 0.293089663 p.(N386V) 0.372006694 9.06E-84 0.12786456 p.(D348A) 0.634108857 8.83E-05 -4.051083495 p.(D348R) 0.347354556 0.002633649 -4.514572884 p.(D348N) 0.509021951 9.13E-13 0.239715635 p.(D348C) 0.702216343 1.10E-75 -1.70118168 p.(D348Q) 0.612836268 3.79E-53 -2.715583315 p.(D348E) 0.645106381 7.40E-58 0.02421723 p.(D348G) 1.570201988 1.78E-15 -1.720730552 p.(D348H) 0.380264628 5.59E-16 -3.71821957 p.(D348I) 0.917276311 6.87E-05 -3.478344384 p.(D348L) 0.801872517 8.36E-110 -2.951709506 p.(D348K) 1.104744174 4.44E-16 -2.885694188 p.(D348M) 1.21002088 3.87E-11 -2.879327767 p.(D348F) 0.383563942 4.27E-31 -3.096988214 p.(D348P) 1.002472845 4.45E-12 -2.397973845 p.(D348S) 0.398842018 4.23E-06 -4.117901772 p.(D348T) 1.31065713 0 -1.60350363 p.(D348W) 0.558811135 9.25E-08 -3.802986626 p.(D348Y) 0.826095369 2.73E-20 -3.930014042 p.(D348V) 1.39048619 4.11E-11 -3.362876665 p.(D368A) 0.729895984 5.75E-97 0.151158411 p.(D368R) 0.733047776 3.09E-53 -1.020171636 p.(D368N) 0.798513083 1.34E-32 0.296698218 p.(D368D) 0.034126548 4.39E-19 -0.47076521 p.(D368C) 0.853114569 6.55E-19 -0.380355448 p.(D368Q) 0.400808223 5.55E-17 0.337337817 p.(D368E) 0.249804769 2.03E-14 -0.215110276 p.(D368G) 0.790680929 4.34E-18 0.266428006 p.(D368H) 0.534752831 7.18E-17 -0.408040592 p.(D368I) 0.444178124 2.06E-59 0.44296725 p.(D368L) 0.373481174 1.97E-05 0.887348706 p.(D368K) 0.800894647 0.000332543 0.188754255 p.(D368M) 0.762663038 4.29E-37 0.182851935 p.(D368F) 0.847246976 5.72E-37 -0.747407978 p.(D368P) 0.831843705 3.04E-07 -2.1165696 p.(D368S) 0.596126702 4.39E-78 0.264300109 p.(D368T) 0.785404063 8.59E-56 0.209365587 p.(D368W) 1.102887034 2.98E-42 -0.067804648 p.(D368Y) 0.859241192 1.06E-26 -0.192084052 p.(D368V) 0.49960936 5.21E-08 0.590939767 p.(C364A) 1.071507096 1.81E-26 -0.791599643 p.(C364R) 1.16739819 3.04E-71 -1.911143269 p.(C364N) 0.886813326 2.64E-05 -2.240988367 p.(C364D) 1.145870593 1.24E-30 -1.680031643 p.(C364C) 0.070172487 9.24E-30 -0.878543794 p.(C364Q) 0.524736983 1.64E-58 0.064471575 p.(C364E) 0.915926135 3.20E-26 0.100403751 p.(C364G) 0.592874813 1.73E-15 0.07083364 p.(C364H) 0.938217314 7.61E-41 -0.163621309 p.(C364I) 0.501260335 2.16E-71 -0.821648123 p.(C364L) 0.869764232 1.48E-49 -0.321957553 p.(C364K) 1.253788896 4.00E-158 -1.874758507 p.(C364M) 0.616707127 4.61E-09 0.305830157 p.(C364F) 0.782414458 8.65E-50 -0.149278084 p.(C364P) 0.781221393 4.39E-12 -2.662760916 p.(C364S) 0.842438606 1.42E-64 -0.012148019 p.(C364T) 0.68866909 8.76E-69 -0.488800099 p.(C364W) 1.198662999 4.99E-66 0.128765214 p.(C364Y) 0.274371144 0 -0.939765568 p.(C364V) 0.46454577 1.35E-13 0.826327095 p.(C383A) 0.619272006 2.27E-08 2.077325389 p.(C383R) 0.270236273 9.70E-06 2.023324495 p.(C383N) 0.226325308 1.15E-54 2.315510118 p.(C383D) 1.041880117 0 3.636489734 p.(C383C) 0.342861241 0 0.222647873 p.(C383Q) 0.390058461 3.29E-09 1.94499779 p.(C383E) 0.671115183 0 3.167840278 p.(C383G) 0.349586826 0 1.93343767 p.(C383H) 0.191680716 4.62E-22 1.286879156 p.(C383I) 0.603485968 1.11E-16 1.867692644 p.(C383L) 0.429888309 2.03E-10 1.300772224 p.(C383K) 0.247797899 1.34E-41 0.410493775 p.(C383M) 0.644724211 2.22E-16 1.745465479 p.(C383F) 0.154790958 1.39E-17 0.115661881 p.(C383P) 0.994433422 2.99E-101 -2.229138452 p.(C383S) 0.367209653 1.13E-21 1.669972686 p.(C383T) 0.7302943 0 1.856059771 p.(C383W) 0.224060277 7.64E-97 -0.257333317 p.(C383Y) 0.312353561 1.60E-53 0.290318126 p.(C383V) 0.317648627 7.42E-67 1.052685674 p.(E341A) 0.685835352 3.43E-54 0.560307739 p.(E341R) 0.481036853 8.58E-22 -0.19354463 p.(E341N) 0.419412545 6.06E-20 1.184966954 p.(E341D) 0.176420827 6.94E-18 -0.432281247 p.(E341C) 0.284978744 1.79E-49 -0.292147219 p.(E341Q) 0.57961135 4.69E-45 0.926869282 p.(E341G) 0.330313638 1.11E-16 -0.613148913 p.(E341H) 0.464744231 1.64E-11 0.284410392 p.(E341I) 0.504609565 6.50E-32 -0.249528529 p.(E341L) 0.859603531 6.22E-28 -0.491082963 p.(E341K) 1.331275644 8.88E-16 2.507820166 p.(E341M) 0.672040084 1.29E-57 -0.191792231 p.(E341F) 0.422710837 7.31E-67 0.538269543 p.(E341P) 1.689214549 0 -1.99915422 p.(E341S) 0.429593727 3.25E-66 0.151402502 p.(E341T) 0.955938245 2.77E-47 0.32914516 p.(E341W) 0.551728112 2.10E-38 -0.014732533 p.(E341Y) 0.422775989 4.01E-41 0.640119327 p.(E341V) 0.739784694 3.07E-24 -0.132511547 p.(E357A) 0.569197624 4.41E-79 0.28775687 p.(E357R) 1.014612848 2.76E-37 -0.429705225 p.(E357N) 0.982990901 4.89E-110 -0.051080383 p.(E357D) 0.795667219 0.002557757 0.313434363 p.(E357C) 0.460082553 3.71E-37 -0.161947382 p.(E357Q) 0.436793217 3.65E-92 0.210478745 p.(E357G) 0.843353148 9.92E-48 -0.018659599 p.(E357H) 0.836161997 4.75E-38 -1.014737782 p.(E357I) 0.934846458 7.40E-14 -0.065803977 p.(E357L) 0.399049123 3.60E-73 0.070112737 p.(E357K) 0.281709404 5.50E-86 -0.631072235 p.(E357M) 0.855639024 1.74E-40 0.128451493 p.(E357F) 0.994579472 2.16E-125 -0.247099318 p.(E357P) 0.579766993 5.94E-108 0.211723484 p.(E357S) 0.581763542 2.48E-07 -0.103841571 p.(E357T) 0.754069463 6.20E-55 -0.248394288 p.(E357W) 0.920745344 1.82E-43 -0.227840746 p.(E357Y) 0.783563413 1.62E-43 -0.561412448 p.(E357V) 0.684058335 2.03E-31 0.220547778 p.(E371A) 0.3730083 3.82E-12 0.295146033 p.(E371R) 0.667649436 4.84E-09 -0.166333626 p.(E371N) 0.912944409 1.41E-19 0.525156111 p.(E371D) 0.204829338 1.01E-16 -0.577847757 p.(E371C) 1.022643759 7.49E-51 -0.510844259 p.(E371Q) 0.452409206 1.39E-13 -0.273569444 p.(E371E) 0.188357641 1.94E-24 -0.179154514 p.(E371G) 0.777821381 1.15E-101 -0.260719959 p.(E371H) 0.726863426 7.50E-40 -0.535957994 p.(E371I) 0.545085755 2.64E-55 -0.289971321 p.(E371L) 0.581713623 2.46E-33 -0.009185719 p.(E371K) 0.36547155 3.50E-59 0.01187763 p.(E371M) 0.946994994 6.66E-53 -0.524632564 p.(E371F) 0.674822214 3.60E-47 -0.926523471 p.(E371P) 0.81230504 1.57E-22 -0.095469051 p.(E371S) 0.55250085 1.21E-100 -0.542889487 p.(E371T) 0.420611615 5.19E-45 0.078825567 p.(E371W) 0.798295889 8.49E-41 -1.630392535 p.(E371Y) 0.590617024 1.56E-26 -1.089910037 p.(E371V) 0.687923124 4.20E-53 0.278354141 p.(E385A) 0.48983543 1.86E-112 0.049370555 p.(E385R) 1.241544791 1.88E-34 0.817028616 p.(E385N) 0.993513211 5.34E-06 -0.670153313 p.(E385D) 0.431296947 0 0.300863442 p.(E385C) 0.468358697 3.92E-24 -1.285513144 p.(E385Q) 0.958455809 1.69E-16 -0.43526463 p.(E385E) 0.152606773 2.07E-33 -0.599461422 p.(E385G) 0.994332905 3.77E-90 -1.197939408 p.(E385H) 0.968610201 3.40E-13 -0.801001805 p.(E385I) 1.024870426 3.16E-26 -0.270676487 p.(E385L) 0.276046352 4.46E-93 0.153792068 p.(E385K) 0.363696625 2.22E-09 -0.608430049 p.(E385M) 0.747530708 2.12E-86 -0.111877619 p.(E385F) 0.925645255 3.08E-50 -1.03578 p.(E385P) 1.820302587 0 -4.139753532 p.(E385S) 0.401069189 1.34E-75 -0.484825078 p.(E385T) 0.847998373 9.00E-40 -0.555657259 p.(E385W) 0.830559194 7.05E-14 -1.583827994 p.(E385Y) 0.943072693 4.90E-55 -0.78565984 p.(E385V) 0.881094045 4.07E-35 -0.051074045 p.(E387A) 1.552961745 1.47E-40 -1.588528861 p.(E387R) 1.847062376 8.88E-16 -0.959544696 p.(E387N) 1.067583806 1.13E-19 -2.154685723 p.(E387D) 0.605629272 2.53E-56 0.95492055 p.(E387C) 1.760752911 1.85E-103 -1.300551591 p.(E387Q) 1.248941329 5.00E-48 -2.515857652 p.(E387E) 0.184692032 2.29E-13 -0.228719561 p.(E387G) 0.854728863 3.12E-33 -2.024801752 p.(E387H) 0.760850497 1.17E-19 -3.274568858 p.(E387I) 1.986944184 0 -2.138055862 p.(E387L) 1.437299483 1.06E-06 -1.713634776 p.(E387K) 0.304556883 7.26E-47 -2.061223912 p.(E387M) 1.037462615 7.78E-09 -3.281286349 p.(E387F) 1.043134002 1.65E-07 -3.260127344 p.(E387P) 1.415103045 1.25E-114 -2.569300475 p.(E387S) 1.417209735 1.66E-22 -2.607557952 p.(E387T) 1.865156219 8.88E-16 -4.317892996 p.(E387W) 0.571476172 2.28E-09 -3.58847572 p.(E387Y) 1.541269214 2.27E-07 -1.934353869 p.(E387V) 0.886994344 1.94E-10 -2.983921393 p.(H343A) 0.763748474 0 0.173627509 p.(H343R) 0.667438173 0 1.152439286 p.(H343N) 0.153243314 1.94E-37 0.020977009 p.(H343D) 0.376028578 0 0.297786183 p.(H343C) 0.819816063 2.36E-77 0.554939135 p.(H343Q) 0.311723981 7.78E-78 0.881778034 p.(H343E) 1.116137235 8.88E-16 2.620900199 p.(H343G) 0.381794053 1.06E-07 0.448385326 p.(H343I) 0.623905379 2.52E-69 0.168758698 p.(H343L) 0.365816161 0 0.460756918 p.(H343K) 0.313851247 8.53E-05 0.792528967 p.(H343M) 0.089440693 5.66E-70 -0.309487578 p.(H343F) 0.145644798 9.07E-21 -0.527495259 p.(H343P) 0.907919784 1.51E-59 0.013073598 p.(H343S) 0.505670876 0 0.537874142 p.(H343T) 0.477676509 2.09E-34 0.736025116 p.(H343W) 0.700657336 3.84E-75 -0.553454972 p.(H343Y) 0.77532883 6.47E-36 0.011781178 p.(H343V) 0.546567441 1.26E-47 -0.058208769 p.(H353A) 0.905351287 6.98E-112 -0.412748232 p.(H353R) 0.702515287 9.57E-39 -3.21349548 p.(H353N) 0.534176938 8.22E-24 0.270325026 p.(H353D) 0.645507193 1.84E-30 0.393160825 p.(H353C) 0.856228976 9.98E-45 -0.277710905 p.(H353Q) 0.110475452 3.51E-09 -0.063151722 p.(H353E) 0.498467053 3.82E-30 0.984053043 p.(H353G) 0.79029666 2.78E-25 -0.063093676 p.(H353I) 0.330197607 1.99E-36 -3.962852022 p.(H353L) 0.856332494 0.005418999 -1.685688429 p.(H353K) 0.336792597 1.82E-12 -4.722041729 p.(H353M) 0.950733858 2.48E-08 -0.671879672 p.(H353F) 0.494737918 8.98E-86 -0.087813649 p.(H353P) 1.160531756 4.44E-16 -2.995334206 p.(H353S) 0.236158471 2.22E-12 0.552249329 p.(H353T) 0.892035279 1.22E-85 -2.385648062 p.(H353W) 0.947113264 4.46E-31 -1.17031788 p.(H353Y) 0.859126202 2.84E-33 -1.119072895 p.(H353V) 0.617674402 3.35E-16 -4.506321858 p.(I375A) 0.868047831 0 0.928052504 p.(I375R) 0.367156397 2.19E-11 1.10938706 p.(I375N) 0.324086376 2.35E-09 0.735751891 p.(I375D) 0.53177078 0 1.841823481 p.(I375C) 0.325282912 1.45E-96 1.978462443 p.(I375Q) 0.477708219 1.11E-16 2.553116956 p.(I375E) 0.290408659 2.11E-24 1.951130858 p.(I375G) 1.005862307 8.88E-16 2.239939638 p.(I375H) 0.314390124 2.45E-12 1.243861426 p.(I375I) 0.229592429 4.52E-10 -0.239409061 p.(I375L) 0.752217562 0 1.651532422 p.(I375K) 0.442603373 6.77E-28 0.984091047 p.(I375M) 0.355152771 2.96E-58 0.53260062 p.(I375F) 0.768508621 8.22E-48 -0.822439413 p.(I375P) 0.280265946 9.78E-07 0.767503942 p.(I375S) 1.150748796 0 1.818145398 p.(I375T) 0.399448595 2.25E-09 1.79940677 p.(I375W) 0.839997197 1.15E-76 -0.186397282 p.(I375Y) 0.501438818 9.93E-66 0.073271577 p.(I375V) 0.362861797 1.29E-16 1.318968128 p.(L363A) 0.139194164 1.62E-28 1.280354583 p.(L363R) 0.566361966 9.98E-56 -0.472062076 p.(L363N) 0.363582377 0 1.120238779 p.(L363D) 0.464114803 6.72E-07 1.632410311 p.(L363C) 0.314341531 6.36E-22 1.422594954 p.(L363Q) 0.593160291 0 0.782302522 p.(L363E) 0.256244701 1.12E-11 1.492757046 p.(L363G) 0.490716249 4.47E-67 0.074562224 p.(L363H) 0.311822174 1.51E-41 0.881598196 p.(L363I) 1.446268656 1.78E-15 2.070465964 p.(L363L) 0.09036648 3.17E-58 0.61468375 p.(L363K) 0.650206935 4.69E-88 -0.608364709 p.(L363M) 0.237243126 9.55E-36 1.012147078 p.(L363F) 0.425777932 0.000955321 1.137801408 p.(L363P) 0.731800366 0 2.444479469 p.(L363S) 0.224617962 3.19E-45 0.892674268 p.(L363T) 0.660312808 1.94E-30 -0.902473984 p.(L363W) 0.271820281 1.31E-29 0.017375879 p.(L363Y) 0.448742644 2.13E-43 0.440309193 p.(L363V) 0.404138493 2.07E-10 0.877497396 p.(L369A) 1.601007626 0 -2.355875759 p.(L369R) 1.028528819 0.009739072 -2.328453096 p.(L369N) 0.886374667 7.06E-47 -2.050614047 p.(L369D) 0.879105232 1.01E-121 -2.942821158 p.(L369C) 0.696651685 4.75E-51 0.481662213 p.(L369Q) 1.057996333 1.21E-16 -1.553361168 p.(L369E) 0.465349163 3.55E-20 -3.221469493 p.(L369G) 0.545750965 5.94E-15 -4.322891688 p.(L369H) 0.616662906 1.48E-32 -0.277687641 p.(L369I) 0.603641596 0 1.812969525 p.(L369L) 0.473388116 4.39E-29 0.605182679 p.(L369K) 0.687982797 1.12E-75 -2.385812277 p.(L369M) 0.785341896 4.23E-45 0.199343175 p.(L369F) 0.466023272 0 0.54099554 p.(L369P) 0.891258135 0.003170958 -2.588772871 p.(L369S) 1.644001646 8.88E-16 -1.414430697 p.(L369T) 1.035343592 7.17E-100 -1.996800625 p.(L369W) 0.895656385 2.22E-16 1.746027722 p.(L369Y) 0.556521513 1.23E-25 0.140226776 p.(L369V) 0.315741575 2.88E-10 2.377804011 p.(L376A) 0.496200273 5.55E-17 0.885972165 p.(L376R) 0.781092922 0 1.657110082 p.(L376N) 0.465336088 5.83E-11 1.171692367 p.(L376D) 0.66854557 4.44E-16 2.830408041 p.(L376C) 0.323911755 2.80E-101 1.189234632 p.(L376Q) 0.618268189 0 1.839496304 p.(L376E) 0.754668033 0 2.540581146 p.(L376G) 0.396483512 1.82E-14 0.511490784 p.(L376H) 0.931843994 0 2.063940085 p.(L376I) 0.275594722 9.75E-58 0.000766139 p.(L376L) 0.291482685 5.04E-46 -0.150702731 p.(L376K) 0.230521029 2.10E-18 -0.054820395 p.(L376M) 0.195067348 0 -0.285897593 p.(L376F) 0.330380163 8.64E-41 -0.095629637 p.(L376P) 0.318889908 8.82E-72 1.446175067 p.(L376S) 0.478276199 1.11E-16 1.199454455 p.(L376T) 0.447721471 0.000190863 1.815776933 p.(L376W) 0.248923133 8.36E-58 0.265435032 p.(L376Y) 0.407090926 4.26E-29 0.558006202 p.(L376V) 0.136001439 1.70E-28 1.069808206 p.(K342A) 0.597592447 0 0.50861716 p.(K342R) 0.174096118 2.08E-17 -0.39671758 p.(K342N) 0.610073854 2.22E-16 0.384890623 p.(K342D) 0.429574272 5.55E-17 0.273512372 p.(K342C) 0.625861727 2.51E-62 -0.348317306 p.(K342Q) 0.485604838 2.33E-39 -0.20457193 p.(K342E) 0.70268242 4.44E-16 -0.450686034 p.(K342G) 0.218692924 3.12E-10 0.454699164 p.(K342H) 0.224334814 1.39E-17 -0.975290637 p.(K342I) 0.486155429 5.46E-103 0.250171431 p.(K342L) 0.606973851 2.30E-10 -0.435306927 p.(K342K) 0.105422853 2.90E-53 0.250482158 p.(K342M) 0.429882557 3.25E-17 -0.988170129 p.(K342F) 0.613749029 1.12E-67 -0.23759097 p.(K342P) 0.432632975 5.51E-45 0.762547776 p.(K342S) 0.493404789 0.000694523 0.239374969 p.(K342T) 0.230144804 6.72E-100 -0.036836402 p.(K342W) 0.952280843 1.19E-75 -0.646036958 p.(K342Y) 0.72624858 3.84E-61 -0.132224399 p.(K342V) 0.559745119 1.72E-96 0.113837588 p.(K346A) 0.71193708 1.45E-98 -0.071478105 p.(K346R) 0.065639202 1.08E-08 0.205748003 p.(K346N) 0.105273594 8.14E-25 -1.01115617 p.(K346D) 0.383408671 2.60E-07 -0.98130281 p.(K346C) 1.00214498 5.69E-53 -0.3690849 p.(K346Q) 0.69656743 1.11E-16 -0.341237897 p.(K346E) 0.159726905 3.92E-11 -0.421779323 p.(K346G) 0.479403535 6.68E-32 0.52395887 p.(K346H) 0.353048337 1.24E-62 1.013683419 p.(K346I) 0.898794115 4.97E-82 -0.511703906 p.(K346L) 0.782127467 1.12E-93 -0.713521531 p.(K346M) 0.468587224 2.85E-76 -0.40627446 p.(K346F) 0.812732794 6.40E-45 -0.747141844 p.(K346P) 2.148734855 0.033260274 -4.496428988 p.(K346S) 0.293912919 7.32E-06 0.325632113 p.(K346T) 0.50729488 8.10E-37 -0.425569315 p.(K346W) 0.906330831 1.50E-69 -0.746470945 p.(K346Y) 0.936086821 2.29E-62 -0.780818893 p.(K346V) 0.864163802 2.74E-40 -1.079848704 p.(K354A) 0.463481489 1.11E-16 0.369290908 p.(K354R) 0.435860746 1.11E-16 0.44799773 p.(K354N) 0.180865334 4.63E-123 1.070835592 p.(K354D) 0.435025006 2.78E-16 2.023135055 p.(K354C) 0.418442598 1.80E-07 0.37821422 p.(K354Q) 0.358798904 1.11E-16 1.646847761 p.(K354E) 0.190408388 0 0.85788775 p.(K354G) 0.392528288 0.000163079 1.255405671 p.(K354H) 0.27266759 9.93E-42 0.928048195 p.(K354I) 0.410184321 0 0.352463233 p.(K354L) 1.042692987 0 1.463080121 p.(K354M) 0.673510682 0 1.136826522 p.(K354F) 0.397364465 2.41E-90 0.245572396 p.(K354P) 0.271188981 2.69E-67 -4.934313014 p.(K354S) 0.386013292 2.40E-101 0.233394787 p.(K354T) 0.969019 0 2.024072002 p.(K354W) 0.857672458 5.82E-33 -0.366074585 p.(K354Y) 0.56038217 2.17E-35 -0.164157956 p.(K354V) 0.275572478 4.80E-66 1.143204074 p.(K372A) 0.159975485 5.42E-50 1.314326651 p.(K372R) 0.27754389 2.17E-70 1.026583316 p.(K372N) 0.455306361 1.11E-16 1.241625364 p.(K372D) 0.344555298 5.55E-17 1.222428976 p.(K372C) 0.42984517 1.52E-37 0.766280371 p.(K372Q) 0.425868625 1.11E-16 2.536468251 p.(K372E) 0.289782322 1.31E-09 1.771178354 p.(K372G) 1.138966996 0 3.093831075 p.(K372H) 0.240921876 1.98E-58 1.443028904 p.(K372I) 1.145970574 1.79E-19 -0.776180518 p.(K372L) 0.189137584 5.87E-69 -0.290390495 p.(K372M) 0.348670906 4.74E-13 1.018406524 p.(K372F) 0.524881903 8.18E-47 -0.033545979 p.(K372P) 0.361889606 8.82E-28 1.1414552 p.(K372S) 0.916272889 0 1.325938548 p.(K372W) 0.741922205 1.44E-14 -0.55904032 p.(K372Y) 0.953644443 4.44E-16 0.700881375 p.(K372V) 0.343482581 2.74E-60 0.057249757 p.(K373A) 0.278920768 3.53E-30 0.929034703 p.(K373R) 0.111146777 5.85E-25 1.071289687 p.(K373N) 0.385337718 2.58E-15 0.701541609 p.(K373D) 0.324783893 9.05E-35 2.429421783 p.(K373C) 0.58937851 2.22E-16 1.205548187 p.(K373Q) 1.372276487 1.78E-15 1.954061499 p.(K373E) 0.217056928 3.84E-94 0.111900017 p.(K373G) 0.383103438 0 1.859540909 p.(K373H) 0.652592419 0 1.153445291 p.(K373I) 0.373082635 2.80E-46 0.585147278 p.(K373L) 0.779610341 9.99E-16 0.566712725 p.(K373K) 0.17634794 1.20E-07 -0.224522308 p.(K373M) 0.363662638 0 0.217980105 p.(K373F) 0.518811425 4.79E-08 -0.348039049 p.(K373P) 0.477421347 3.20E-07 0.551304362 p.(K373S) 0.661294317 6.66E-16 1.83386319 p.(K373T) 0.422965734 2.35E-07 0.916033424 p.(K373W) 0.50551648 2.13E-38 -1.023158323 p.(K373Y) 0.188447207 2.96E-60 -0.20851881 p.(K373V) 0.267812893 1.89E-05 0.127512572 p.(F352A) 1.304707446 1.33E-15 -3.488593128 p.(F352R) 0.857812106 8.61E-06 -3.95448922 p.(F352N) 0.90535864 1.48E-05 -1.903170432 p.(F352D) 0.85067254 2.13E-30 -3.006654548 p.(F352C) 0.627326318 0.003986054 -4.144861176 p.(F352Q) 0.745524489 3.89E-24 -3.375428634 p.(F352E) 1.036918682 8.88E-16 -3.802670934 p.(F352G) 0.753475568 0.001139861 -2.92148191 p.(F352H) 0.703707831 1.70E-21 -3.915977272 p.(F352I) 0.336060911 3.97E-49 0.34282781 p.(F352L) 0.186639735 0 -0.096928206 p.(F352K) 0.893001746 1.05E-53 -2.747968286 p.(F352M) 0.96781185 4.53E-38 0.423573588 p.(F352F) 0.098877552 2.16E-18 -0.686139647 p.(F352P) 0.737853293 1.38E-09 -4.496104711 p.(F352S) 0.794717714 1.23E-34 -3.224250355 p.(F352T) 0.66772982 2.50E-08 -3.716306904 p.(F352W) 0.802310938 2.10E-62 -0.169812885 p.(F352Y) 1.029786747 1.59E-09 -1.118163739 p.(F352V) 0.79941248 0.010849721 -4.27908341 p.(F382A) 0.507786018 0.059842196 1.092440784 p.(F382R) 1.038937083 2.14E-05 -2.57034831 p.(F382N) 0.693107936 2.38E-21 -1.446505148 p.(F382D) 0.684736506 4.99E-06 -1.148645911 p.(F382C) 0.370037475 8.33E-17 1.961793342 p.(F382Q) 1.43151394 1.69E-06 0.420114813 p.(F382E) 1.360545015 8.73E-08 -0.615313395 p.(F382G) 1.358814512 7.46E-49 -0.005811706 p.(F382H) 0.823240862 1.40E-55 -0.183901977 p.(F382I) 0.114541513 4.95E-39 1.02451816 p.(F382L) 0.593185463 0 1.476482673 p.(F382K) 1.321558454 1.64E-18 -2.308427673 p.(F382M) 0.455926854 5.83E-13 1.626214181 p.(F382F) 0.244693442 5.55E-17 -0.986411585 p.(F382P) 0.512835334 0.003903314 -0.265702317 p.(F382S) 1.389478954 4.92E-84 0.296477215 p.(F382T) 0.651507571 5.01E-75 0.835240475 p.(F382W) 0.646272831 2.81E-39 -0.03970657 p.(F382Y) 0.337583814 8.53E-08 -0.31078138 p.(F382V) 0.622132078 0 1.69975569 p.(P359A) 0.300110241 8.33E-17 1.457914432 p.(P359R) 0.472290523 3.09E-31 -0.401482282 p.(P359N) 0.186325052 7.69E-78 1.018005648 p.(P359D) 0.526052859 1.89E-11 1.577810421 p.(P359C) 0.682087539 6.76E-50 0.27691609 p.(P359Q) 0.346560255 4.70E-09 1.666109338 p.(P359E) 1.205000589 0 4.101945076 p.(P359G) 0.735067468 4.44E-15 0.88094764 p.(P359H) 0.354217207 1.32E-39 -0.346704901 p.(P359I) 0.706917791 3.07E-159 -0.14134864 p.(P359L) 0.682043917 5.23E-45 0.22600313 p.(P359K) 0.367648584 4.93E-29 0.442942575 p.(P359M) 0.48831171 3.07E-79 0.572479164 p.(P359F) 0.773210719 2.70E-76 -0.941682999 p.(P359P) 0.646322813 0 0.988752998 p.(P359S) 0.643169197 2.22E-16 0.665436975 p.(P359T) 0.504206217 3.21E-81 0.948475869 p.(P359W) 1.039910886 9.26E-09 -2.043240316 p.(P359Y) 0.568064202 3.83E-08 -0.637872296 p.(P359V) 0.281495105 4.35E-48 0.496109588 p.(P362A) 0.860196739 6.28E-11 -3.014821357 p.(P362R) 0.806007212 2.28E-22 -2.82087143 p.(P362N) 0.526492855 8.07E-07 -4.267096935 p.(P362D) 0.687269992 3.39E-09 -4.797175415 p.(P362C) 1.074847111 2.65E-27 -1.879577894 p.(P362Q) 0.296022752 7.15E-37 -3.64639778 p.(P362E) 0.657441808 6.15E-07 -3.560394738 p.(P362G) 0.70391614 4.49E-08 -2.939417811 p.(P362H) 0.503683841 2.89E-08 -4.05210037 p.(P362I) 1.504987469 6.93E-13 -1.677973117 p.(P362L) 0.996103781 0 -2.453534588 p.(P362K) 0.780252512 0.000270316 -2.564888424 p.(P362M) 1.911897917 4.44E-15 -2.000372506 p.(P362F) 0.787276103 7.02E-05 -3.333165953 p.(P362P) 0.290696385 0 0.376051749 p.(P362S) 0.727611326 5.09E-10 -3.067487963 p.(P362T) 0.673752979 2.54E-44 -3.652409676 p.(P362W) 1.820288475 1.78E-15 -1.299398573 p.(P362Y) 0.362737606 8.29E-10 -4.663371576 p.(P362V) 0.902781774 4.62E-22 -1.794675427 p.(S350A) 0.595944167 6.27E-30 0.719625928 p.(S350R) 0.516150259 0 1.404579416 p.(S350N) 0.686832858 0 0.656431883 p.(S350D) 0.508230103 3.48E-48 0.923957243 p.(S350C) 0.464882653 9.98E-11 0.493564915 p.(S350Q) 0.225418596 4.71E-15 0.971407926 p.(S350E) 0.567982262 1.11E-16 1.919395752 p.(S350G) 0.211853333 1.57E-45 0.748481969 p.(S350H) 0.422593109 1.49E-06 -0.024253149 p.(S350I) 0.874349411 4.39E-29 0.549351061 p.(S350L) 0.614202369 5.36E-47 0.381862633 p.(S350K) 0.194808746 2.13E-11 2.143708392 p.(S350M) 0.806611458 2.28E-33 0.022300393 p.(S350F) 0.395459367 6.60E-33 -0.367305829 p.(S350P) 0.592270377 1.19E-63 -1.527958581 p.(S350S) 0.446454386 3.51E-35 0.581953467 p.(S350T) 0.132893824 1.94E-54 0.792110694 p.(S350W) 1.067477647 1.84E-117 -0.680566982 p.(S350Y) 0.60791766 8.59E-96 -0.084910107 p.(S350V) 1.030233081 2.35E-47 -0.640956141 p.(S365A) 0.854640751 3.53E-41 -0.310111835 p.(S365R) 0.41491239 1.59E-14 -2.650612102 p.(S365N) 0.517934883 5.77E-40 -1.920084432 p.(S365D) 0.478697431 1.47E-48 -4.148890365 p.(S365C) 0.687882458 1.17E-60 0.663096173 p.(S365Q) 1.316993326 0 -3.321155587 p.(S365E) 0.665776915 1.60E-07 -4.245049566 p.(S365G) 0.388553654 0 -2.256563214 p.(S365H) 0.684111711 6.96E-16 -3.640288074 p.(S365I) 1.25452928 8.88E-16 -4.676549976 p.(S365L) 0.754256733 1.48E-27 -3.755872463 p.(S365K) 0.974394448 2.83E-11 -3.110596075 p.(S365M) 0.732853327 3.57E-87 -2.880240351 p.(S365F) 0.855808414 7.40E-14 -3.133631925 p.(S365P) 1.521544248 0 -3.068944977 p.(S365S) 0.418073511 2.01E-102 0.99117209 p.(S365T) 1.144576541 2.36E-06 -2.830886617 p.(S365W) 0.918552224 4.00E-74 -2.847311509 p.(S365Y) 0.699062713 3.26E-40 -3.617337769 p.(S365V) 0.965266728 0 -4.02808307 p.(S377A) 0.415827039 5.93E-05 0.973596607 p.(S377R) 0.347432918 1.27E-32 0.515775845 p.(S377N) 0.42723921 2.16E-19 0.531028092 p.(S377D) 0.521683595 2.54E-12 1.20591487 p.(S377C) 0.266909016 2.71E-35 0.497024446 p.(S377Q) 0.339845305 2.99E-06 0.606109138 p.(S377E) 0.502643462 1.39E-11 1.770153978 p.(S377G) 0.398436203 0.000323523 0.986993703 p.(S377H) 0.487311269 1.01E-31 0.326439525 p.(S377I) 0.578129612 4.24E-36 0.005165618 p.(S377L) 0.485141009 1.75E-15 0.269031582 p.(S377K) 0.480029433 0.000474714 -0.296935881 p.(S377M) 0.470575729 1.80E-71 -0.443789976 p.(S377F) 0.235510155 1.12E-31 -0.054153958 p.(S377P) 0.786698568 4.44E-16 2.337615025 p.(S377S) 0.147385411 6.38E-21 -0.469833996 p.(S377T) 0.226342998 9.94E-09 0.743862234 p.(S377W) 0.606335947 7.17E-27 -0.043716959 p.(S377Y) 0.235786209 0 -0.672210903 p.(S377V) 0.468108086 2.07E-35 0.357407427 p.(S381A) 0.588718317 3.94E-39 0.469656674 p.(S381R) 0.458532022 1.36E-63 -0.443850929 p.(S381N) 1.002256574 7.33E-15 0.447132516 p.(S381D) 0.433550876 4.73E-11 0.127501323 p.(S381C) 0.683304582 5.52E-57 0.319306162 p.(S381Q) 0.404783549 1.11E-16 0.837426943 p.(S381E) 0.293668821 2.75E-47 0.708071267 p.(S381G) 0.206393698 5.30E-16 1.13927319 p.(S381H) 0.528126552 9.18E-28 -0.070036556 p.(S381I) 0.323561331 7.02E-40 -0.372475374 p.(S381L) 0.631505898 4.46E-22 -0.259426685 p.(S381K) 0.904669686 6.79E-177 -0.193265731 p.(S381M) 0.551127912 8.73E-22 -0.258597264 p.(S381F) 0.983851751 9.18E-39 -0.231086534 p.(S381P) 0.63754716 8.90E-20 0.509063179 p.(S381S) 0.152413608 3.30E-20 0.112123832 p.(S381T) 0.371934341 1.32E-24 1.481270358 p.(S381W) 0.888937202 9.50E-60 -0.364266988 p.(S381Y) 1.031105393 6.06E-27 -0.485583035 p.(S381V) 0.871193835 4.44E-16 0.157706694 p.(T355A) 1.134759724 8.52E-54 -1.799835789 p.(T355R) 0.854540895 1.12E-14 -2.268133006 p.(T355N) 0.825123173 8.07E-48 -2.777087912 p.(T355D) 1.215788874 1.77E-12 -1.180858794 p.(T355C) 0.933368235 1.98E-54 0.304188367 p.(T355Q) 0.766637132 3.40E-11 -2.803223613 p.(T355E) 0.843147571 1.13E-06 -3.263458391 p.(T355G) 1.852116326 0 -2.435268433 p.(T355H) 1.611710908 1.30E-10 -0.76813389 p.(T355I) 1.081099958 1.52E-68 -1.528726756 p.(T355L) 1.802311656 9.29E-09 -1.043373831 p.(T355K) 0.388551816 1.37E-18 -2.89825227 p.(T355M) 0.978444633 6.33E-44 -0.456182087 p.(T355F) 0.960877867 6.15E-39 -2.61162813 p.(T355P) 1.017571684 2.43E-08 -2.556778291 p.(T355S) 0.464742071 7.32E-68 -0.745814375 p.(T355T) 0.262051824 0 0.548139355 p.(T355W) 0.660158153 0.005975878 -3.261855952 p.(T355Y) 2.390038008 0 -1.700779242 p.(T355V) 0.270533343 0.00056148 0.706252357 p.(T361A) 0.326293624 7.10E-80 0.761544259 p.(T361R) 0.69629086 1.77E-84 -3.113191295 p.(T361N) 0.918521177 4.53E-06 -2.506717224 p.(T361D) 1.337580599 3.45E-128 -2.298714537 p.(T361C) 0.576070609 3.56E-42 0.412219125 p.(T361Q) 0.515628849 3.73E-16 -0.145548659 p.(T361E) 0.675031591 2.83E-31 -0.377129011 p.(T361G) 1.003120064 0.00450473 -2.104077988 p.(T361H) 0.487782247 2.78E-16 1.325796035 p.(T361I) 0.53064347 1.11E-16 -0.978998913 p.(T361L) 1.840668213 3.08E-29 -1.718056323 p.(T361K) 0.244657162 7.38E-85 -3.195764085 p.(T361M) 0.393992541 2.71E-35 2.720678169 p.(T361F) 0.586429277 2.00E-13 1.628018755 p.(T361P) 1.348506546 1.28E-23 -2.107477111 p.(T361S) 0.630652932 5.48E-61 0.744205426 p.(T361T) 0.203654909 3.52E-46 0.871750835 p.(T361W) 1.744948219 0 -3.133299971 p.(T361Y) 1.558121157 4.48E-54 -1.192859331 p.(T361V) 0.471519153 1.41E-54 0.834512163 p.(Y344A) 0.298272138 0.000345258 0.6119525 p.(Y344R) 0.431946155 0 2.555609105 p.(Y344N) 0.5003187 5.55E-17 1.598438361 p.(Y344D) 0.369366224 6.16E-20 1.848743908 p.(Y344C) 0.294485782 1.53E-16 1.00982802 p.(Y344Q) 0.411707001 2.92E-91 0.934343445 p.(Y344E) 0.642460039 0 -0.157233459 p.(Y344G) 0.417369139 0 0.690972719 p.(Y344H) 0.064577492 1.77E-45 0.496244708 p.(Y344I) 0.333537141 2.15E-09 -0.529799044 p.(Y344L) 0.208220177 1.30E-31 0.938101573 p.(Y344K) 1.19543322 0 2.810686877 p.(Y344M) 0.394363828 1.11E-16 -0.602183108 p.(Y344F) 0.512954377 0 0.484844266 p.(Y344P) 0.834391773 0 0.52495149 p.(Y344S) 0.325683271 6.72E-46 0.442215708 p.(Y344T) 0.450563367 1.11E-16 0.639358676 p.(Y344W) 0.248865877 4.27E-36 0.740396476 p.(Y344V) 0.576976548 1.11E-16 1.869869235 p.(Y345A) 0.607309623 1.81E-52 0.109652129 p.(Y345R) 0.34441065 1.23E-76 -0.207027569 p.(Y345N) 0.163670925 1.72E-36 0.579815399 p.(Y345D) 0.439381775 8.02E-46 -2.834824792 p.(Y345C) 0.157311643 0 -0.050710419 p.(Y345Q) 0.330443901 2.35E-09 1.26255463 p.(Y345E) 0.896302516 4.25E-51 -0.924491293 p.(Y345G) 0.904538071 5.30E-11 -1.638037188 p.(Y345H) 0.338017244 1.17E-15 1.765130274 p.(Y345I) 0.250876679 6.10E-10 0.849628092 p.(Y345L) 0.804786429 1.11E-15 2.227188548 p.(Y345K) 0.211580696 0.000223359 1.206247634 p.(Y345M) 0.264260325 0.000671179 0.511744408 p.(Y345F) 0.392516378 0 0.942967995 p.(Y345P) 0.141370832 3.49E-44 0.251459994 p.(Y345S) 0.809918341 2.03E-107 -0.450970226 p.(Y345T) 0.84359791 5.44E-51 0.347163022 p.(Y345W) 0.445993817 1.88E-48 0.060423618 p.(Y345V) 0.117683427 4.19E-68 1.288957925 p.(Y349A) 0.321351252 1.80E-10 0.84795822 p.(Y349R) 0.390171004 6.81E-05 1.582574268 p.(Y349N) 0.191709065 1.53E-09 -0.355219995 p.(Y349D) 0.759382646 5.88E-15 0.686408305 p.(Y349C) 0.761777978 0 1.252848026 p.(Y349Q) 0.332953128 5.15E-19 1.173189653 p.(Y349E) 0.52583669 1.86E-50 0.450890178 p.(Y349G) 0.610441163 1.11E-16 0.457369354 p.(Y349H) 0.257935268 6.09E-12 1.303008146 p.(Y349I) 0.477603318 3.14E-20 -0.095760082 p.(Y349L) 0.425299543 5.64E-15 1.18600318 p.(Y349K) 1.020393657 0 0.172374075 p.(Y349M) 0.514379478 4.99E-40 -0.080716725 p.(Y349F) 0.72600366 2.45E-50 0.488013192 p.(Y349P) 0.262647979 3.49E-05 1.285938346 p.(Y349S) 0.136744334 1.26E-16 1.080215508 p.(Y349T) 0.698492945 0 1.389722627 p.(Y349W) 0.351053125 1.66E-26 -0.222411007 p.(Y349V) 0.340362625 4.14E-17 0.162987114 p.(Y356A) 1.302866777 1.78E-15 3.573310927 p.(Y356R) 0.332726677 1.72E-64 2.386634248 p.(Y356N) 0.452142756 4.46E-08 0.5091388 p.(Y356D) 2.69934614 3.55E-15 -3.693472595 p.(Y356C) 0.998939021 8.88E-16 4.156127764 p.(Y356Q) 0.258855967 2.03E-11 3.922649391 p.(Y356E) 0.664681799 1.02E-44 3.028496746 p.(Y356G) 0.997265764 4.73E-113 -1.768076728 p.(Y356H) 0.308822249 2.03E-50 1.988854419 p.(Y356I) 0.797729663 4.44E-16 3.349128001 p.(Y356L) 0.673646696 0 3.641405142 p.(Y356K) 0.484257422 5.55E-17 2.600092767 p.(Y356M) 0.883629225 0 3.714605197 p.(Y356F) 0.407590952 8.15E-24 1.556261551 p.(Y356P) 0.54285915 5.60E-32 -4.343704266 p.(Y356S) 1.577647204 0 3.282184347 p.(Y356T) 0.891589581 0 4.725138049 p.(Y356W) 0.357612918 0.000158178 1.412720063 p.(Y356Y) 0.146571954 0 -0.234460297 p.(Y356V) 0.794193063 0 3.767118719 p.(Y374A) 0.31408824 8.02E-52 1.937359983 p.(Y374R) 0.253303656 3.91E-59 1.16317016 p.(Y374N) 0.435103305 5.73E-76 0.704242078 p.(Y374D) 1.101163219 0 1.809882272 p.(Y374C) 0.27547576 0.000480493 1.799180828 p.(Y374Q) 0.945146756 0 2.424691035 p.(Y374E) 0.420610528 0 2.860658883 p.(Y374G) 0.164534064 2.01E-19 1.855134591 p.(Y374H) 0.270927179 0 -0.503225526 p.(Y374I) 0.248429263 5.47E-19 0.655645251 p.(Y374L) 0.473973344 2.44E-10 0.606511388 p.(Y374K) 0.223849339 9.59E-24 1.604269862 p.(Y374M) 0.366280205 4.05E-15 0.836017247 p.(Y374F) 0.40075335 0 1.419319003 p.(Y374P) 0.443947491 1.54E-16 1.041009039 p.(Y374S) 0.234788517 1.21E-07 3.171135369 p.(Y374T) 0.421502036 1.59E-07 1.944191721 p.(Y374W) 0.31001755 8.36E-45 0.305423875 p.(Y374Y) 0.114301785 4.57E-19 -0.580932798 p.(Y374V) 0.495538751 0 1.8702246 p.(Y384A) 1.135680566 3.37E-107 -0.051382857 p.(Y384R) 0.782905433 1.00E-37 -0.187987409 p.(Y384N) 0.333796391 7.65E-13 1.892065942 p.(Y384D) 0.953258669 1.79E-08 0.523197644 p.(Y384C) 0.310035102 3.72E-31 1.032341831 p.(Y384Q) 0.289757032 6.48E-08 1.111968787 p.(Y384E) 0.398257668 0.00136567 2.767012804 p.(Y384G) 0.868558829 3.85E-06 -0.517320437 p.(Y384H) 0.386844812 2.50E-07 2.029415091 p.(Y384I) 1.224016803 0 4.337880763 p.(Y384L) 0.38711992 1.67E-14 2.752306866 p.(Y384K) 0.624461757 0.004370193 -0.209011051 p.(Y384M) 0.262844829 1.30E-07 2.464140579 p.(Y384F) 0.304722457 5.05E-25 1.142788734 p.(Y384P) 1.233323339 7.55E-15 0.048019361 p.(Y384S) 0.408036922 2.96E-12 0.499703433 p.(Y384T) 0.505120137 5.56E-13 1.553078817 p.(Y384W) 0.354790868 1.06E-40 1.401988011 p.(Y384Y) 0.120497412 2.19E-14 -0.701213197 p.(Y384V) 0.46526257 0 3.298767265 p.(V347A) 0.267103786 0.000756709 2.146062335 p.(V347R) 0.640294199 1.10E-06 -4.695584922 p.(V347N) 0.464768603 3.61E-60 0.288632494 p.(V347D) 0.484563362 1.50E-07 -3.983824451 p.(V347C) 0.430179074 2.13E-20 1.047158676 p.(V347Q) 0.631823863 1.32E-70 -0.239087913 p.(V347E) 0.611341352 1.75E-55 -0.107296738 p.(V347G) 0.299924009 2.13E-104 -0.898984953 p.(V347H) 0.448471054 0 -0.606881411 p.(V347I) 0.473802326 1.34E-38 0.889284456 p.(V347L) 0.294048507 0.000548629 0.793735186 p.(V347K) 0.679902158 0.000442117 -3.283744648 p.(V347M) 0.386883891 5.07E-73 1.402516902 p.(V347F) 0.285864992 8.62E-40 0.864747442 p.(V347P) 0.578170563 5.99E-12 -4.597211673 p.(V347S) 0.64155972 1.11E-16 0.709761619 p.(V347T) 0.540566041 1.67E-16 1.351383778 p.(V347W) 0.640015114 2.35E-58 -0.11218007 p.(V347Y) 0.325873755 8.59E-05 0.440940244 p.(V347V) 0.205214289 1.31E-43 -0.344656586 p.(V358A) 0.795929416 2.22E-16 1.363249248 p.(V358R) 1.438640559 0 -3.436927163 p.(V358N) 1.062969518 2.66E-15 -2.242896308 p.(V358D) 0.489779935 0.000717516 0.904455716 p.(V358C) 0.193073157 6.24E-87 0.201551842 p.(V358Q) 0.574764036 1.71E-08 0.941601034 p.(V358E) 1.088614805 0 3.907754648 p.(V358G) 0.472973746 2.25E-11 -3.710833992 p.(V358H) 0.902112808 1.77E-29 -0.064709877 p.(V358I) 0.472153347 4.24E-33 0.36120371 p.(V358L) 0.545526541 4.17E-33 0.594167553 p.(V358K) 0.607960968 1.70E-33 -4.360574006 p.(V358M) 0.573441998 7.26E-25 0.941462985 p.(V358F) 0.415502472 1.23E-26 -0.929601234 p.(V358P) 0.517231594 0.000394355 -2.967227001 p.(V358S) 0.704644289 1.45E-39 0.336437396 p.(V358T) 0.50379429 1.46E-64 -0.04059455 p.(V358W) 0.740633149 2.81E-126 -0.131567971 p.(V358Y) 1.522651184 1.91E-40 0.060249991 p.(V388A) 0.281273636 9.81E-32 1.509336228 p.(V388R) 0.264292037 3.05E-16 0.959331221 p.(V388N) 0.365474702 1.01E-53 2.718390288 p.(V388D) 0.443272453 7.52E-17 2.453075584 p.(V388C) 0.284071916 1.20E-08 1.105423615 p.(V388Q) 0.157811457 0.00018548 1.851293145 p.(V388E) 0.534292508 2.10E-68 1.726006229 p.(V388G) 0.36081199 2.78E-17 2.563750737 p.(V388H) 0.294143214 3.63E-16 2.540158789 p.(V388I) 0.535088206 3.22E-15 1.532645794 p.(V388L) 0.075831105 1.68E-12 -0.794632898 p.(V388K) 0.264751932 3.94E-23 0.184865541 p.(V388M) 0.494451631 0 -0.084079792 p.(V388F) 0.343176816 0 0.997103047 p.(V388P) 0.209545045 2.77E-08 1.349676842 p.(V388S) 1.010497371 0 3.084820008 p.(V388T) 0.39282619 2.68E-15 2.578545913 p.(V388W) 0.29429112 2.73E-07 0.562962578 p.(V388Y) 0.514346309 0 0.537421544 p.(A389A) 0.129515589 2.48E-15 -0.183156532 p.(A389N) 0.246806697 0.000210603 2.434577401 p.(A389D) 0.260615932 1.45E-25 0.793778982 p.(A389C) 0.427733235 1.79E-49 0.59990053 p.(A389Q) 0.423197873 8.23E-07 2.988090593 p.(A389E) 0.342486856 7.70E-12 1.9723236 p.(A389G) 0.691199577 2.22E-16 2.061797174 p.(A389H) 0.595461329 1.11E-16 2.404957639 p.(A389I) 0.871353609 0 2.264556282 p.(A389L) 0.361071237 0.00018194 1.73605688 p.(A389K) 0.295300951 2.00E-10 1.271654706 p.(A389M) 0.693447883 4.44E-16 1.257266614 p.(A389F) 0.300789605 3.30E-23 0.547856832 p.(A389P) 0.474767252 0 1.99019837 p.(A389S) 0.23364227 1.71E-82 -0.193763054 p.(A389T) 0.295584765 1.16E-07 0.519290044 p.(A389W) 0.224106999 3.15E-100 -0.101707498 p.(A389Y) 0.54095032 9.21E-11 1.120616251 p.(A389V) 0.244763057 1.86E-06 1.629361555 p.(A421R) 0.401659412 2.07E-63 0.638984127 p.(A421N) 0.590609553 0 1.422306292 p.(A421D) 0.352789305 2.66E-15 -0.29528596 p.(A421C) 0.603789734 0 0.725594985 p.(A421Q) 0.595835844 6.08E-30 0.898765907 p.(A421E) 0.28853808 3.65E-05 1.743945802 p.(A421G) 0.681643442 8.05E-141 0.635751112 p.(A421H) 0.635854797 3.25E-06 1.182822322 p.(A421I) 0.215588892 1.81E-07 1.369376604 p.(A421L) 0.4882041 5.70E-28 1.438757507 p.(A421K) 0.103729209 2.00E-41 -0.194324952 p.(A421M) 0.038285312 1.22E-06 1.196353071 p.(A421F) 0.385279403 0.000454044 0.091747808 p.(A421P) 0.262182885 1.48E-30 0.48710527 p.(A421S) 0.518487052 6.27E-06 -0.015208849 p.(A421T) 0.961105595 2.06E-52 0.189774314 p.(A421W) 0.715653029 3.97E-106 -0.296993862 p.(A421Y) 0.91149826 1.08E-81 -0.209852582 p.(A421V) 0.334763331 4.21E-70 0.866265942 p.(R428A) 1.101128415 1.33E-15 2.050164921 p.(R428R) 0.637455686 1.11E-16 1.676022368 p.(R428N) 0.579917868 8.25E-45 1.3384597 p.(R428D) 0.70920783 2.22E-16 3.051843247 p.(R428C) 0.618551483 0 1.425967574 p.(R428Q) 0.443218397 1.72E-08 0.807346156 p.(R428E) 0.848098366 0 2.585839717 p.(R428G) 0.503756487 1.87E-27 1.281528228 p.(R428H) 0.464058533 9.91E-26 1.439645209 p.(R428I) 0.257904167 8.31E-08 -0.429701043 p.(R428L) 0.517622099 2.24E-16 0.503261174 p.(R428K) 0.684167108 9.16E-130 1.221613354 p.(R428M) 0.531124057 1.85E-68 1.856528728 p.(R428F) 0.398346017 6.23E-05 1.042206321 p.(R428P) 0.488090532 5.55E-17 1.384956915 p.(R428S) 0.43684795 2.08E-11 0.745927308 p.(R428T) 0.761708384 0 1.587307129 p.(R428W) 0.279205623 8.78E-38 0.318609713 p.(R428Y) 0.828243353 6.66E-16 1.313757583 p.(R428V) 0.385561749 4.67E-07 2.122035895 p.(R431A) 1.364204058 0 1.124071255 p.(R431R) 0.349125929 0 0.266688781 p.(R431N) 0.39556511 0 2.203798402 p.(R431D) 0.755006636 0 1.86275382 p.(R431C) 0.353067048 9.91E-14 1.359744913 p.(R431Q) 0.320372525 0 -0.531050059 p.(R431E) 0.95119982 8.88E-16 3.216418893 p.(R431G) 0.587636674 1.72E-39 0.557993947 p.(R431H) 0.468735398 1.19E-22 1.638968348 p.(R431I) 0.516611448 1.81E-11 1.652645031 p.(R431L) 0.490640871 4.35E-06 1.948359362 p.(R431K) 0.688772596 5.94E-55 1.218238307 p.(R431M) 0.729338235 0 1.25179537 p.(R431F) 0.479545909 2.51E-25 1.71548681 p.(R431P) 0.517856278 6.90E-17 1.42485297 p.(R431S) 0.921012354 0 2.305323158 p.(R431T) 0.365403274 3.96E-05 1.331530822 p.(R431W) 0.461406597 0 -0.22674839 p.(R431Y) 0.773975364 2.02E-47 0.283897558 p.(R431V) 0.425682464 1.22E-17 1.192343288 p.(R432A) 0.629477731 0 2.517474131 p.(R432R) 0.252670154 2.41E-75 -0.342459825 p.(R432N) 0.54527909 1.11E-16 2.26735735 p.(R432D) 0.529782502 5.07E-67 1.793903721 p.(R432C) 1.011039978 0 1.235393348 p.(R432Q) 0.773368732 0 2.293481651 p.(R432E) 0.644950406 0 2.321626271 p.(R432G) 0.085190318 2.70E-15 -0.298879773 p.(R432H) 0.755924089 2.30E-138 1.152197819 p.(R432I) 0.414198354 0.000281957 3.093357364 p.(R432L) 0.892865614 5.47E-35 0.899010342 p.(R432K) 0.148603046 1.11E-06 -0.039621247 p.(R432M) 0.22436797 2.27E-08 0.90138935 p.(R432F) 0.590614362 1.67E-16 1.262588238 p.(R432P) 0.517200864 0.000765401 1.584904687 p.(R432S) 0.374126663 2.53E-15 2.533898698 p.(R432T) 1.181887042 4.44E-16 2.599316948 p.(R432W) 0.726371967 5.79E-56 -0.141160548 p.(R432Y) 0.036954856 7.30E-61 1.320997607 p.(R432V) 0.857902762 4.44E-16 2.097255222 p.(N401A) 0.548353791 2.22E-16 1.121089605 p.(N401R) 0.246089626 5.03E-71 0.993081804 p.(N401D) 0.542024456 2.66E-15 1.257571341 p.(N401C) 0.426680251 4.83E-36 0.61592087 p.(N401Q) 0.673103007 3.33E-16 0.829927966 p.(N401E) 0.505754742 0 1.122974017 p.(N401G) 0.45533047 1.30E-44 0.350705894 p.(N401H) 0.720945261 4.22E-47 0.079772926 p.(N401I) 0.13680572 1.45E-06 0.874103528 p.(N401L) 0.454442158 5.72E-06 0.526036977 p.(N401K) 0.57675003 6.82E-85 0.17854813 p.(N401M) 0.658803312 1.86E-51 0.220298128 p.(N401F) 0.540851751 3.02E-65 0.106917801 p.(N401P) 0.354053932 1.96E-36 0.661050681 p.(N401S) 0.415163539 6.55E-40 0.379791743 p.(N401T) 0.538270827 2.56E-07 1.012783448 p.(N401W) 0.832021407 4.52E-15 -0.119691838 p.(N401Y) 0.435903893 4.36E-137 -0.080918406 p.(N401V) 0.294796848 9.49E-25 1.460077341 p.(N419A) 0.419759409 0 1.392652232 p.(N419R) 0.746283168 2.55E-43 0.246376942 p.(N419D) 0.625351414 0 1.391553695 p.(N419C) 0.599271537 3.33E-16 1.468911309 p.(N419Q) 0.259690809 6.24E-14 0.756484366 p.(N419E) 1.088648479 0 1.513691482 p.(N419G) 0.304989299 1.81E-06 0.533001786 p.(N419H) 0.653308561 2.22E-16 0.585897958 p.(N419I) 0.277439954 0.000168989 0.713762554 p.(N419L) 0.283095145 1.94E-34 1.006385727 p.(N419K) 0.406159553 0 0.269479747 p.(N419M) 0.720268557 0 1.536616518 p.(N419F) 1.102789901 1.33E-15 0.308361162 p.(N419P) 0.450369456 2.16E-76 -0.11166628 p.(N419S) 0.39960252 1.13E-28 0.736721777 p.(N419T) 0.438174039 3.31E-48 0.655490625 p.(N419W) 0.710244231 3.62E-37 -0.070694427 p.(N419Y) 0.689802039 0 0.663308751 p.(N419V) 0.274425638 9.22E-65 1.10884669 p.(D398E) 1.037313799 4.44E-16 0.178434055 p.(D410A) 0.105592199 1.43E-39 0.063593335 p.(D410R) 0.4875963 2.00E-14 -0.397634169 p.(D410N) 0.347721364 1.72E-32 0.505115651 p.(D410D) 0.062578115 9.53E-20 -0.328357472 p.(D410C) 0.352580247 3.85E-82 0.690064638 p.(D410Q) 0.224862093 9.11E-30 0.481334705 p.(D410E) 0.267312739 2.78E-17 -0.239278344 p.(D410G) 0.471524489 1.48E-22 0.441387313 p.(D410H) 0.402590561 4.61E-51 -0.044178389 p.(D410I) 0.544230973 0 -0.002255878 p.(D410L) 0.909044067 2.96E-18 0.121799537 p.(D410K) 0.762411604 6.52E-60 -0.308258544 p.(D410M) 0.560379204 4.10E-17 0.812352476 p.(D410F) 0.554306443 1.42E-63 0.280986494 p.(D410P) 0.72780815 4.59E-13 0.635000636 p.(D410S) 0.628040793 1.64E-20 -0.177106868 p.(D410T) 0.579088973 1.44E-85 0.346802959 p.(D410Y) 0.417763819 1.74E-08 -1.089552405 p.(D410V) 0.551377714 2.44E-43 -0.210971952 p.(D416A) 0.428824478 0 -0.071173718 p.(D416R) 0.411325352 5.41E-54 0.380175024 p.(D416N) 0.228606309 2.78E-17 -0.162217829 p.(D416D) 0.135584572 1.09E-15 -0.274809852 p.(D416C) 0.483147744 1.11E-16 0.834615688 p.(D416Q) 0.471896635 4.69E-26 0.544141042 p.(D416E) 0.576896336 0 -0.631566721 p.(D416G) 0.374217183 3.29E-40 0.284787579 p.(D416H) 0.438230147 1.52E-40 0.484017054 p.(D416I) 0.397703165 7.65E-54 0.863884383 p.(D416L) 0.545561718 1.12E-39 0.289271534 p.(D416K) 1.377919676 1.60E-91 -0.754935059 p.(D416M) 0.694379081 1.20E-49 -0.095230835 p.(D416F) 0.713752437 6.04E-33 -0.130041268 p.(D416P) 1.021441583 3.69E-59 0.0322603 p.(D416S) 0.465599659 1.36E-22 0.638846092 p.(D416T) 0.82709403 6.53E-47 0.515087878 p.(D416W) 0.894157263 3.50E-45 -0.347360005 p.(D416Y) 0.690806472 2.35E-54 -0.19030936 p.(D416V) 0.331421266 9.20E-69 -0.150398444 p.(Q420A) 0.353390527 1.78E-50 0.627970019 p.(Q420R) 0.714055238 2.58E-63 0.064582631 p.(Q420N) 0.861508811 5.40E-57 0.464486558 p.(Q420D) 0.301563239 1.74E-25 1.997546041 p.(Q420C) 0.837157452 6.93E-30 0.345230079 p.(Q420Q) 0.165196072 0.000146101 0.216269083 p.(Q420E) 0.362376331 2.19E-37 2.872311379 p.(Q420G) 0.503848239 0.002718316 1.342372638 p.(Q420H) 0.310787978 2.10E-29 0.252079656 p.(Q420I) 1.017917216 2.22E-16 1.380373089 p.(Q420L) 0.489958517 1.04E-18 0.381806235 p.(Q420K) 0.604371706 1.39E-56 -0.346018107 p.(Q420M) 0.60547644 0.004062098 0.803419021 p.(Q420F) 0.938461141 1.50E-39 -0.006665821 p.(Q420P) 0.627016918 0 1.459374098 p.(Q420S) 0.74658361 2.09E-09 0.610024078 p.(Q420T) 0.533659333 3.14E-13 0.850876959 p.(Q420W) 0.573251145 3.53E-48 -0.436427991 p.(Q420Y) 0.653739631 6.06E-22 0.632764023 p.(Q420V) 0.131125341 2.60E-05 0.77067785 p.(E394A) 0.661382604 0 0.378606096 p.(E394R) 0.25486691 2.79E-55 0.479701952 p.(E394N) 0.387825743 0.002531006 1.532472962 p.(E394D) 0.275146505 1.86E-56 0.494528767 p.(E394C) 0.168246216 8.93E-09 0.347735754 p.(E394Q) 0.547762184 1.67E-60 0.938682952 p.(E394E) 0.088548829 1.43E-12 -0.068294461 p.(E394G) 0.10378824 1.54E-17 -0.462265115 p.(E394H) 0.642430988 9.68E-07 0.598637774 p.(E394I) 0.346164092 1.73E-10 0.128936783 p.(E394L) 0.705176326 2.29E-13 -0.092905283 p.(E394K) 0.835611755 3.45E-08 -0.166058412 p.(E394M) 0.729599465 1.36E-26 0.114570053 p.(E394F) 1.067741192 2.78E-47 -0.458898582 p.(E394P) 0.581980172 1.03E-28 -0.448133524 p.(E394S) 0.287706463 5.41E-15 1.551368839 p.(E394T) 0.716221924 1.07E-15 0.624046023 p.(E394W) 0.607887702 1.10E-21 -0.769313619 p.(E394Y) 0.259476586 4.71E-115 -0.052125322 p.(E394V) 0.345716939 4.06E-36 0.63114332 p.(E395A) 0.589043047 1.65E-11 0.276742039 p.(E395R) 0.680650488 2.22E-44 0.394177963 p.(E395N) 0.569229283 3.09E-95 0.78812655 p.(E395D) 0.393682314 3.02E-106 0.611126179 p.(E395C) 0.134387666 2.78E-137 0.377499433 p.(E395Q) 0.340627601 1.71E-07 0.582431684 p.(E395G) 0.165847917 5.74E-22 0.14381303 p.(E395H) 0.477894852 5.10E-87 0.108689944 p.(E395I) 0.545300714 2.96E-65 0.182683006 p.(E395L) 0.655250951 2.00E-34 0.117385751 p.(E395K) 0.144013749 5.06E-05 -0.871505855 p.(E395M) 0.416190747 6.12E-115 0.024989817 p.(E395F) 0.439752033 9.46E-33 0.604489495 p.(E395P) 0.220154655 2.40E-13 0.7391381 p.(E395S) 0.50675578 6.15E-44 0.492587754 p.(E395T) 0.407742548 5.82E-85 0.536008605 p.(E395W) 0.492092666 7.61E-83 -0.892981293 p.(E395Y) 0.635718153 7.65E-102 -0.004944702 p.(E395V) 0.450125563 1.81E-52 0.831043101 p.(E396A) 0.633214437 9.15E-30 0.547919558 p.(E396R) 0.342314581 1.05E-07 0.267756158 p.(E396N) 0.509383983 3.35E-24 0.65477824 p.(E396D) 0.388368083 1.79E-82 0.928172088 p.(E396C) 0.807697215 1.14E-105 0.20812625 p.(E396Q) 0.201688462 2.14E-59 0.738542412 p.(E396G) 0.411330049 2.20E-05 1.502811278 p.(E396H) 0.531289956 3.31E-48 0.991049268 p.(E396I) 0.722772352 3.49E-40 0.303132281 p.(E396L) 0.379662008 2.11E-37 -0.00548415 p.(E396K) 0.690520942 8.11E-62 0.275020716 p.(E396M) 0.688490457 3.32E-57 0.098896218 p.(E396F) 0.301288944 4.48E-117 -0.144757174 p.(E396P) 0.190443551 1.03E-14 0.946990368 p.(E396S) 0.193179092 7.55E-26 0.718991195 p.(E396T) 0.548649762 2.84E-24 0.675609617 p.(E396W) 0.71282097 1.10E-43 -0.237218265 p.(E396Y) 0.437907708 2.87E-23 0.487008506 p.(E396V) 0.720526762 0 0.95583496 p.(E397A) 0.580181824 4.59E-35 0.182773021 p.(E397R) 0.330758657 3.09E-10 0.665271368 p.(E397N) 0.698978392 1.97E-47 0.631530117 p.(E397D) 0.232849793 6.56E-29 0.512235942 p.(E397C) 0.407172931 3.13E-09 0.313188447 p.(E397Q) 0.51236097 3.07E-48 0.317140794 p.(E397G) 0.174114532 8.04E-81 0.799083128 p.(E397H) 0.143417199 3.16E-08 0.709704932 p.(E397I) 0.675406169 3.20E-29 0.469407667 p.(E397L) 0.956689215 8.50E-50 0.223533048 p.(E397K) 0.47223795 8.11E-21 0.16761055 p.(E397M) 0.390138013 5.43E-24 0.335180989 p.(E397F) 0.573139591 4.94E-28 0.12818781 p.(E397P) 0.24755264 1.20E-09 0.367314965 p.(E397S) 0.647518732 9.11E-13 1.325071708 p.(E397T) 0.297894437 1.86E-105 0.87733973 p.(E397W) 0.568382982 7.63E-69 -0.152789067 p.(E397Y) 0.398041066 5.47E-70 0.268694597 p.(E397V) 0.34749054 3.02E-90 0.751849765 p.(E400A) 0.258672354 2.09E-20 0.866946296 p.(E400R) 0.348131508 4.97E-21 0.18612035 p.(E400N) 0.3155904 2.60E-67 -0.021522988 p.(E400D) 0.4927651 2.08E-54 0.611841772 p.(E400C) 0.298850217 2.66E-14 0.617265774 p.(E400Q) 0.256176899 3.91E-45 0.63943912 p.(E400G) 0.572544774 1.17E-64 1.231272096 p.(E400H) 0.669015632 2.36E-15 0.681843881 p.(E400I) 0.635742729 9.04E-113 0.106604556 p.(E400L) 0.660626947 0 0.372862914 p.(E400K) 0.396449776 2.12E-67 0.586979275 p.(E400M) 0.428953845 5.48E-07 0.829875604 p.(E400F) 0.574062797 1.14E-24 0.621097682 p.(E400P) 0.133932449 3.74E-52 1.089435711 p.(E400S) 0.302403268 7.78E-73 0.866169059 p.(E400T) 0.613338698 2.22E-16 1.666304094 p.(E400W) 0.678714395 1.49E-12 0.243155154 p.(E400Y) 0.708409284 7.04E-47 -0.271310278 p.(E400V) 0.190501832 0.000115053 0.19613225 p.(E405A) 0.506824798 2.19E-112 0.214219723 p.(E405R) 0.343258412 8.50E-78 0.374874236 p.(E405N) 0.388023535 1.77E-44 0.608002928 p.(E405D) 0.385611425 1.89E-62 0.785969826 p.(E405C) 0.395580691 1.14E-36 -0.188105911 p.(E405Q) 0.22896723 0.001096087 -0.145567483 p.(E405G) 0.555625418 1.68E-06 0.999726777 p.(E405H) 0.119396327 5.97E-12 -0.125643468 p.(E405I) 0.194026563 2.51E-25 0.645900195 p.(E405L) 0.623399147 3.68E-40 0.390607041 p.(E405K) 0.955361566 2.13E-42 -0.007791657 p.(E405M) 0.221582174 1.95E-29 0.04524108 p.(E405F) 0.934674237 1.12E-44 -0.041026477 p.(E405P) 0.611330381 1.23E-37 0.115103652 p.(E405S) 0.612872573 0.002432426 1.457809951 p.(E405T) 0.471766806 5.74E-05 0.785570569 p.(E405W) 0.477034705 4.01E-14 -0.187381665 p.(E405Y) 0.612796264 3.68E-15 -1.080191791 p.(E426A) 0.498496759 1.67E-16 -0.348993141 p.(E426R) 0.718106981 7.39E-45 0.045850926 p.(E426N) 0.749948975 2.33E-68 0.427672247 p.(E426D) 0.095688666 3.26E-57 0.729608659 p.(E426C) 1.008196862 4.25E-39 -0.130249815 p.(E426Q) 0.570902318 2.83E-34 0.059407269 p.(E426E) 0.150305128 1.51E-36 -0.119897169 p.(E426G) 0.048290208 2.47E-10 -0.649963007 p.(E426H) 0.405504984 4.90E-46 -0.216919772 p.(E426I) 0.232615768 6.23E-49 -0.23048537 p.(E426L) 1.094019896 3.42E-65 -0.247451196 p.(E426K) 0.215210909 2.18E-25 -0.852492336 p.(E426M) 0.77889487 1.47E-106 0.068942983 p.(E426F) 0.938319301 4.41E-26 -0.704602029 p.(E426P) 0.822063861 9.29E-46 0.037070141 p.(E426S) 0.55672768 3.33E-16 1.766675517 p.(E426T) 0.495087917 3.40E-50 1.354564266 p.(E426W) 0.465773309 9.90E-41 -0.822195612 p.(E426Y) 0.509521891 3.25E-60 -0.365850551 p.(E426V) 0.549467088 4.20E-39 -0.139936843 p.(E433A) 0.511161626 9.99E-15 0.985564395 p.(E433R) 0.729991234 1.29E-77 0.142718195 p.(E433N) 1.023563413 6.61E-52 0.533335916 p.(E433D) 0.227572504 5.55E-17 0.386357052 p.(E433C) 0.519893221 5.55E-17 0.417907273 p.(E433Q) 0.107255407 3.37E-69 1.142313041 p.(E433G) 0.947834089 2.22E-16 0.870555362 p.(E433H) 0.75888378 8.86E-47 -0.18108171 p.(E433I) 0.903830087 6.30E-41 0.078547163 p.(E433L) 0.618486326 1.67E-12 0.80337326 p.(E433K) 0.263401958 1.38E-54 1.101672631 p.(E433M) 0.984723699 0 0.399402259 p.(E433F) 1.079208004 5.81E-38 0.238190156 p.(E433S) 0.423346731 2.60E-19 0.014328599 p.(E433T) 0.209956824 2.03E-65 0.898256235 p.(E433W) 0.772905031 5.41E-24 -0.068908033 p.(E433Y) 0.492116229 5.04E-06 0.013940021 p.(E433V) 0.660549971 1.77E-21 0.793952427 p.(E435A) 0.737032145 6.01E-82 0.236212195 p.(E435R) 1.155460581 8.72E-85 0.27771901 p.(E435N) 0.480343443 8.64E-07 1.684991235 p.(E435D) 0.275606658 2.06E-06 2.337744155 p.(E435C) 0.564967459 2.71E-72 -0.418075696 p.(E435Q) 0.962077604 4.44E-16 0.71600001 p.(E435E) 0.20712751 3.01E-14 -0.568832988 p.(E435G) 0.334230251 5.15E-44 -0.310081887 p.(E435H) 0.882297045 5.25E-69 -0.14917951 p.(E435I) 1.120185124 1.14E-23 -0.323708682 p.(E435L) 1.074265877 9.58E-26 -0.624471667 p.(E435K) 0.405356288 6.18E-44 -1.216542007 p.(E435M) 0.561020675 5.79E-09 1.259859087 p.(E435F) 0.28073408 4.71E-62 0.463267237 p.(E435P) 0.632301255 6.58E-39 -0.13971571 p.(E435S) 0.536539742 4.81E-11 1.928118189 p.(E435T) 0.471085839 7.37E-14 -0.052347713 p.(E435W) 0.457181434 4.16E-44 0.063711314 p.(E435Y) 0.745569722 3.22E-63 -0.550168574 p.(E435V) 0.77621421 1.01E-43 0.763524128 p.(G402A) 0.622892572 2.22E-16 0.975083391 p.(G402R) 0.420209246 3.46E-06 0.266550882 p.(G402N) 0.479686655 3.05E-25 1.119694064 p.(G402D) 0.351944981 2.41E-34 0.900016002 p.(G402C) 0.551614616 1.64E-48 0.434339988 p.(G402Q) 0.448134603 4.86E-13 1.424713858 p.(G402E) 0.196702276 1.39E-17 -0.017299473 p.(G402G) 0.60809205 6.36E-51 0.681239677 p.(G402H) 0.767512169 0 0.518356677 p.(G402I) 0.507155583 1.05E-05 1.161755456 p.(G402L) 0.444482669 3.31E-46 0.486639699 p.(G402K) 0.735974493 7.55E-27 -0.206295954 p.(G402M) 0.787239964 1.03E-09 2.380828414 p.(G402F) 0.422865502 2.29E-38 0.714599823 p.(G402P) 0.307435972 2.28E-29 1.225054481 p.(G402S) 0.463428563 1.77E-71 1.46102095 p.(G402T) 0.226895418 2.39E-50 0.562973557 p.(G402W) 0.656578403 7.32E-60 0.642877358 p.(G402Y) 0.854370336 0 0.886418351 p.(G402V) 0.366083968 5.55E-17 -0.729316224 p.(G414A) 0.704804223 4.70E-08 1.067398848 p.(G414R) 0.314369889 1.35E-14 0.549698511 p.(G414N) 0.199411298 1.98E-42 0.883089766 p.(G414D) 0.250666816 0 -0.709147141 p.(G414C) 0.409446893 5.55E-17 -0.347598414 p.(G414Q) 0.391448963 0.000145523 1.770798309 p.(G414E) 0.232534409 9.42E-29 1.99783235 p.(G414H) 0.38129021 3.20E-18 0.852190621 p.(G414I) 0.15975964 4.44E-17 0.473694146 p.(G414L) 0.536596429 1.06E-49 -2.729193127 p.(G414K) 0.385455336 5.71E-12 0.110185967 p.(G414M) 0.618450582 4.06E-27 0.208212261 p.(G414F) 0.709933634 4.27E-40 0.048890764 p.(G414P) 0.357995655 1.16E-110 0.843930932 p.(G414S) 0.452423485 5.98E-79 1.056389345 p.(G414T) 0.399389688 0.000226602 0.954789762 p.(G414W) 0.862289701 1.96E-78 -0.670991675 p.(G414Y) 0.915768172 7.47E-57 -0.421062972 p.(G414V) 0.54343511 1.29E-07 0.895136726 p.(H418A) 0.500407872 3.34E-12 0.816704985 p.(H418R) 0.141340002 4.02E-06 0.524451497 p.(H418N) 0.881954082 0 1.484443085 p.(H418D) 0.226915645 2.76E-19 0.871178472 p.(H418C) 0.244422483 2.55E-27 0.427455089 p.(H418Q) 0.350704926 2.71E-28 1.412824144 p.(H418E) 1.17436797 0 1.518511262 p.(H418G) 0.246152416 1.12E-53 1.431612793 p.(H418I) 0.567185079 0.000220125 1.235867407 p.(H418L) 1.025031685 0 1.546460341 p.(H418K) 0.544450392 1.63E-29 0.94058203 p.(H418M) 0.350329575 8.55E-36 1.023124505 p.(H418F) 0.626665172 0.000924663 0.861138269 p.(H418P) 0.549850428 7.24E-23 -0.150334315 p.(H418S) 0.35287391 1.69E-21 0.522144996 p.(H418T) 0.861092077 5.22E-10 1.369095241 p.(H418W) 0.516087056 6.03E-20 -0.398686734 p.(H418Y) 0.349333328 1.81E-26 0.524742987 p.(H418V) 0.798222655 0 1.678739722 p.(I415A) 0.526465068 1.67E-16 0.921117227 p.(I415R) 1.001416669 5.34E-52 -0.069313525 p.(I415N) 0.607834353 3.65E-06 1.364934641 p.(I415D) 1.137831602 8.88E-16 2.468988638 p.(I415C) 0.642692211 3.33E-16 2.270620044 p.(I415Q) 0.602961233 1.11E-16 1.500219715 p.(I415E) 0.996910032 0 2.431844543 p.(I415G) 0.716656519 2.22E-16 1.620616067 p.(I415H) 0.434212214 9.29E-26 0.581229217 p.(I415I) 0.553006616 3.37E-51 0.539177169 p.(I415L) 0.204687196 6.02E-47 1.372477201 p.(I415K) 0.769570532 0 0.812131822 p.(I415M) 0.315213915 4.88E-23 1.190464997 p.(I415F) 0.231802677 4.09E-16 0.53456945 p.(I415P) 0.100802296 3.01E-12 1.754651859 p.(I415S) 0.740378174 4.61E-62 0.563358883 p.(I415T) 0.522226379 8.83E-08 1.235736173 p.(I415W) 0.516733804 4.47E-46 0.161882052 p.(I415Y) 0.904001043 0.000109529 -1.097355017 p.(I415V) 0.339445697 2.63E-57 1.586638564 p.(I436A) 0.482002534 2.03E-29 1.292461932 p.(I436R) 0.185101826 8.59E-17 0.678539274 p.(I436N) 0.432622846 0 -0.893685988 p.(I436D) 0.31815838 8.83E-27 2.0900212 p.(I436C) 0.85372714 0 1.196989211 p.(I436Q) 0.569378859 2.57E-85 0.579062763 p.(I436E) 0.62644704 4.31E-76 1.685919387 p.(I436G) 0.415170616 1.59E-39 1.617405241 p.(I436H) 0.565276268 3.33E-16 0.963064632 p.(I436L) 1.406557763 8.88E-16 1.663397198 p.(I436K) 1.237265129 8.88E-16 0.202593738 p.(I436M) 0.342557263 4.91E-09 -0.079677568 p.(I436F) 0.82149677 0 0.417579702 p.(I436P) 0.371591051 0 0.396320185 p.(I436S) 1.152450209 0 2.211356518 p.(I436T) 0.664014631 6.65E-38 1.649255987 p.(I436W) 0.453710613 4.00E-53 1.403122819 p.(I436Y) 0.470496537 1.00E-10 0.39912457 p.(I436V) 0.771775924 4.08E-51 1.33341015 p.(L390A) 0.813525347 0 2.033519949 p.(L390R) 0.316214488 0.001892303 2.444572014 p.(L390N) 0.623855862 4.44E-16 3.668947043 p.(L390D) 1.037271987 0 2.80601426 p.(L390C) 0.814024001 0 2.963381866 p.(L390Q) 0.762200129 0 3.32350356 p.(L390E) 0.46348137 0.000149824 2.954041065 p.(L390G) 0.859427138 0 3.92462364 p.(L390H) 0.237525834 6.85E-07 2.03881304 p.(L390I) 0.315523208 5.13E-12 1.282227855 p.(L390L) 0.10818252 4.16E-14 0.021291502 p.(L390K) 0.396032129 2.85E-11 0.909735497 p.(L390M) 0.461032001 2.79E-35 1.496858533 p.(L390F) 0.785644546 0 1.361603962 p.(L390P) 0.276052315 0.000157202 -0.065232053 p.(L390S) 0.407347178 1.78E-09 2.365295538 p.(L390T) 0.603190002 0 3.402508674 p.(L390W) 0.815616557 3.11E-48 -0.229696066 p.(L390Y) 0.660393983 4.85E-21 0.469681815 p.(L390V) 0.782209943 2.22E-16 2.147789369 p.(L417A) 0.473051356 1.60E-05 0.86245926 p.(L417R) 0.601144776 5.91E-50 0.032363719 p.(L417N) 0.213536912 1.67E-25 1.550622865 p.(L417D) 0.176715324 4.32E-24 1.247409421 p.(L417C) 0.562287484 4.15E-12 0.936568486 p.(L417Q) 0.595060445 4.47E-29 0.87889896 p.(L417E) 0.515086961 0 2.081844938 p.(L417G) 0.398518542 1.44E-11 1.605130879 p.(L417H) 0.645117772 4.55E-42 -0.478922576 p.(L417I) 0.53414914 1.50E-15 0.498658003 p.(L417L) 0.087008061 1.59E-15 -0.424110236 p.(L417K) 0.414672224 2.37E-55 0.099739107 p.(L417M) 0.153205404 1.54E-37 -0.163878142 p.(L417F) 0.794456448 2.24E-39 0.200493867 p.(L417P) 0.634470094 0 0.927483671 p.(L417S) 0.539018299 0 0.861209839 p.(L417T) 0.5068975 3.85E-36 0.311831095 p.(L417W) 0.768473212 1.40E-28 -0.136478918 p.(L417Y) 0.498085822 2.95E-66 0.44385134 p.(L417V) 0.461116814 0.000311588 1.465283281 p.(L425A) 0.656700256 9.22E-05 1.129953854 p.(L425R) 0.426171228 3.33E-30 0.975992459 p.(L425N) 0.497155598 6.60E-41 1.027816072 p.(L425D) 0.896298998 0 2.454272978 p.(L425C) 0.502288568 9.45E-21 1.328422904 p.(L425Q) 1.181685415 0 1.979015772 p.(L425E) 0.362646443 1.00E-50 1.346874936 p.(L425G) 0.394836374 5.55E-17 1.079019155 p.(L425H) 0.389014801 1.71E-19 -0.029172772 p.(L425I) 0.366274824 1.23E-13 1.3086201 p.(L425L) 0.583343996 4.90E-12 0.76189057 p.(L425K) 0.808961142 2.07E-27 0.105987954 p.(L425M) 0.289687736 1.61E-14 0.034541378 p.(L425F) 0.292440503 1.50E-33 0.134202901 p.(L425P) 0.338468121 3.41E-17 1.341058482 p.(L425S) 0.586607326 0 0.651763889 p.(L425T) 0.834059121 0 1.705704792 p.(L425W) 0.834715792 1.94E-54 -0.208294038 p.(L425Y) 0.31623441 1.27E-42 1.77386964 p.(L425V) 0.565152361 2.85E-17 0.474782916 p.(L430A) 0.319774364 9.97E-07 0.809356627 p.(L430R) 0.760556555 2.22E-16 1.397513763 p.(L430N) 0.371804849 7.53E-31 0.466003017 p.(L430D) 0.580528288 0 1.316361982 p.(L430C) 0.286670014 5.91E-22 1.003404843 p.(L430Q) 0.530421902 1.72E-12 0.77199979 p.(L430E) 0.583048981 0 1.708613615 p.(L430G) 0.724291241 7.34E-40 1.005114869 p.(L430H) 0.777171856 0 1.316582997 p.(L430I) 0.567481719 1.57E-18 0.949334604 p.(L430L) 0.866301345 0 0.694308015 p.(L430K) 0.656694815 4.65E-16 0.291122234 p.(L430M) 0.529180795 3.68E-28 0.549297965 p.(L430F) 0.374438971 2.80E-72 0.906185445 p.(L430P) 0.161141982 4.11E-11 0.009982896 p.(L430S) 0.324438533 1.87E-26 1.30242419 p.(L430T) 0.456755396 0.001503605 0.801390504 p.(L430W) 0.850859392 9.74E-38 0.031348176 p.(L430Y) 0.642224151 9.46E-55 -0.239079418 p.(L430V) 0.402542073 2.78E-17 0.378254759 p.(K393A) 0.39345337 0 1.5834201 p.(K393R) 0.727348647 0 1.737500726 p.(K393N) 0.099461035 2.05E-14 0.550962995 p.(K393D) 0.443360179 7.02E-10 1.524062652 p.(K393C) 0.965310831 0 0.618699324 p.(K393Q) 0.523239528 1.11E-16 2.059482317 p.(K393E) 0.099118003 2.08E-17 0.396698426 p.(K393G) 1.297816372 0 2.239559177 p.(K393H) 0.430668462 1.29E-12 1.623272964 p.(K393I) 0.17949106 4.05E-19 -0.089958265 p.(K393L) 0.386646233 4.59E-56 0.686558155 p.(K393K) 0.227785267 5.55E-17 -0.706578205 p.(K393M) 0.151398189 1.55E-34 1.350292224 p.(K393F) 0.293701256 3.08E-19 0.756168449 p.(K393P) 0.494755394 2.78E-16 1.848879807 p.(K393S) 0.445876115 2.01E-33 1.436600373 p.(K393T) 0.918344509 4.44E-16 2.022019643 p.(K393W) 0.973702447 1.70E-48 -0.210581875 p.(K393Y) 0.343719394 1.82E-72 -0.026157202 p.(K393V) 0.688059185 1.99E-29 0.243377213 p.(P404A) 0.386565148 4.21E-13 0.264574345 p.(P404R) 0.249830864 2.07E-71 0.041391535 p.(P404N) 0.693966308 1.45E-14 1.339648755 p.(P404D) 0.5339964 7.77E-07 0.941339468 p.(P404C) 0.524421494 1.11E-07 1.146038203 p.(P404Q) 0.521176117 2.58E-59 1.036513236 p.(P404E) 0.535094186 0.002485953 0.624415076 p.(P404G) 0.266590819 9.95E-13 0.140574214 p.(P404H) 0.184506326 9.80E-25 0.035572757 p.(P404I) 0.108300338 4.95E-57 0.890201032 p.(P404L) 0.251553362 1.37E-18 0.524064273 p.(P404K) 0.575240521 0 0.70712002 p.(P404M) 0.598266575 2.05E-46 0.41246548 p.(P404F) 0.287160413 0.000290637 0.429946272 p.(P404P) 0.200962216 0 -0.560525978 p.(P404S) 0.307453167 5.70E-67 1.487545217 p.(P404T) 0.121679171 1.43E-15 0.072129698 p.(P404W) 0.395731475 3.08E-14 0.94569156 p.(P404Y) 0.36547288 0.001457748 0.77148849 p.(P404V) 0.294853396 2.13E-13 0.459973564 p.(P412A) 0.917227546 6.66E-16 1.824262469 p.(P412R) 0.550232785 3.07E-45 0.616202562 p.(P412N) 0.684277741 0 1.710309138 p.(P412D) 1.567247185 0 2.761989427 p.(P412C) 0.303357705 4.41E-07 1.24343916 p.(P412Q) 0.642842369 8.18E-06 0.657773971 p.(P412E) 0.330102142 7.65E-40 1.866346104 p.(P412G) 0.585019108 5.62E-05 1.007553786 p.(P412H) 0.603603282 1.93E-71 0.591685935 p.(P412I) 0.573378729 0 1.920849782 p.(P412L) 0.188255628 4.21E-07 0.399313685 p.(P412K) 1.051592866 3.89E-44 0.032481521 p.(P412M) 0.520453952 3.44E-15 0.739979894 p.(P412F) 0.763468102 1.43E-20 0.561875897 p.(P412P) 0.40095299 3.96E-65 0.79948814 p.(P412S) 0.123976322 1.24E-17 0.670087397 p.(P412T) 0.67012784 9.93E-25 1.364374271 p.(P412W) 0.499838482 1.19E-102 -0.173586682 p.(P412Y) 0.155794334 9.42E-98 0.120400605 p.(P412V) 0.471044345 9.27E-35 0.262150044 p.(P413A) 0.323372742 0 1.145297351 p.(P413R) 0.316070613 1.51E-56 -0.249128475 p.(P413N) 1.055264183 4.44E-16 0.801480927 p.(P413D) 0.442666032 3.45E-45 1.15300983 p.(P413C) 0.523511606 3.28E-23 0.637309616 p.(P413Q) 0.426972942 5.84E-27 0.730589828 p.(P413E) 1.037259892 0 1.705930607 p.(P413G) 0.537705425 1.25E-11 0.814043464 p.(P413H) 0.23095535 4.16E-17 0.153922465 p.(P413I) 0.949581978 0 1.475247354 p.(P413L) 0.396943322 1.75E-06 0.681836669 p.(P413K) 0.341720354 1.52E-71 0.636974891 p.(P413M) 0.454840909 1.71E-07 1.511129664 p.(P413F) 0.615079893 1.51E-88 0.049872496 p.(P413P) 0.103965966 1.50E-37 0.292893713 p.(P413S) 0.295726712 1.88E-10 2.215052424 p.(P413T) 0.684148363 2.66E-15 1.226119325 p.(P413W) 0.722452736 4.35E-10 0.139536503 p.(P413Y) 0.469680927 6.11E-42 0.533361309 p.(P413V) 0.305470385 4.33E-47 0.613847874 p.(P424A) 0.545230017 2.19E-10 0.824058488 p.(P424R) 0.463998488 0 0.364060078 p.(P424N) 0.501239929 4.85E-46 0.427758536 p.(P424D) 0.895232142 0 2.373449291 p.(P424C) 0.656796973 2.66E-60 1.002908253 p.(P424Q) 0.475483213 7.22E-16 1.408216123 p.(P424E) 0.544333212 9.67E-08 1.554483448 p.(P424G) 0.45008181 1.80E-32 1.162178193 p.(P424H) 0.220842433 1.20E-30 -0.365763267 p.(P424I) 0.555227966 1.83E-39 0.83347221 p.(P424L) 0.218369126 3.20E-05 -0.927737156 p.(P424K) 0.657148272 2.95E-10 0.31786182 p.(P424M) 0.354222857 5.55E-17 1.586501161 p.(P424F) 0.65371741 5.55E-16 1.367094416 p.(P424P) 0.185659249 1.62E-08 0.166922983 p.(P424S) 0.560711947 4.29E-11 1.508760239 p.(P424T) 0.094683611 1.55E-67 -0.063381216 p.(P424W) 0.508799779 5.51E-09 0.130824935 p.(P424Y) 0.819462983 4.44E-16 0.91025982 p.(P424V) 0.364751578 1.16E-65 1.404081222 p.(P427A) 0.076658139 3.03E-26 1.508921063 p.(P427R) 0.479418816 0 -0.874074951 p.(P427N) 0.84586029 4.44E-16 0.720852533 p.(P427D) 1.075153327 1.33E-15 2.06141564 p.(P427C) 0.940048774 1.11E-15 0.708382482 p.(P427Q) 0.646014913 6.21E-14 -0.438688268 p.(P427E) 0.347977693 1.11E-16 -1.049331594 p.(P427G) 0.347977693 1.11E-16 -1.049331594 p.(P427H) 0.651221555 2.21E-66 0.179911735 p.(P427I) 1.308149068 1.33E-15 1.234301488 p.(P427L) 0.347977693 1.11E-16 -1.049331594 p.(P427K) 0.929599674 1.16E-85 -0.536971156 p.(P427F) 0.873063942 1.68E-52 -0.54770993 p.(P427P) 0.14800711 2.20E-19 -0.497530632 p.(P427S) 0.60272315 2.65E-11 0.978592663 p.(P427T) 0.263873163 4.06E-15 0.925021938 p.(P427W) 0.470159403 5.55E-17 -0.872767331 p.(P427Y) 0.616532124 1.75E-92 0.180765478 p.(P427V) 0.167776298 5.71E-06 0.307381473 p.(P429A) 0.714504287 4.44E-16 1.767386048 p.(P429R) 0.267942365 1.04E-16 1.152827915 p.(P429N) 0.542940752 3.52E-58 0.61172505 p.(P429C) 0.910362857 2.14E-54 0.656222133 p.(P429Q) 0.602085651 0 0.775302558 p.(P429E) 0.697264013 2.22E-16 1.624936241 p.(P429G) 0.891062616 3.18E-09 0.287246503 p.(P429H) 0.137023282 6.91E-61 -0.434185345 p.(P429I) 0.483129447 0 1.193165832 p.(P429L) 0.556447954 1.32E-40 1.038589409 p.(P429K) 0.891370273 1.85E-47 -0.282370598 p.(P429M) 0.392580649 1.98E-18 2.158277832 p.(P429F) 0.652891384 4.02E-33 0.803658745 p.(P429P) 0.327634038 3.87E-64 0.55470673 p.(P429S) 0.77650787 1.67E-13 2.128028317 p.(P429T) 0.26700438 1.52E-14 -0.244281311 p.(P429W) 0.320547383 9.81E-52 0.543767162 p.(P429Y) 0.789004066 1.03E-64 0.014425249 p.(P429V) 0.453811751 6.91E-12 1.280263153 p.(S392A) 0.469309167 8.59E-09 1.59463586 p.(S392R) 0.452964227 2.60E-75 0.804812953 p.(S392N) 0.275173351 5.84E-09 1.790147498 p.(S392D) 0.515679964 0.00073962 1.496548086 p.(S392C) 0.520830423 4.45E-19 0.342871062 p.(S392Q) 0.181436678 5.94E-44 1.435043266 p.(S392E) 0.525741486 0 1.313466441 p.(S392G) 0.361263495 1.77E-100 1.471107583 p.(S392H) 0.385544173 4.95E-08 1.196518903 p.(S392I) 0.765911614 6.62E-48 -0.288803625 p.(S392L) 0.717729158 5.81E-14 -0.537341372 p.(S392K) 0.436752135 2.47E-66 0.570909375 p.(S392M) 0.439791318 1.10E-10 0.128902159 p.(S392F) 0.596602111 7.34E-25 -0.219476863 p.(S392P) 0.528708217 0 1.467638609 p.(S392S) 0.086186443 5.22E-33 0.264235408 p.(S392T) 0.19907261 2.06E-15 1.034881791 p.(S392W) 0.74100672 1.56E-17 -1.053288261 p.(S392Y) 0.695765916 1.25E-06 -0.448684708 p.(S392V) 0.550028 2.89E-57 -0.207210378 p.(S399A) 0.836778446 2.22E-16 2.724098939 p.(S399R) 0.428600448 7.64E-85 0.581460412 p.(S399N) 0.532871243 5.62E-12 0.672292482 p.(S399D) 0.299919963 1.69E-33 0.422789405 p.(S399C) 0.519007561 5.68E-07 0.72862001 p.(S399Q) 0.423689358 2.66E-79 0.41707376 p.(S399E) 0.467368665 6.04E-85 1.288631435 p.(S399G) 0.383811442 1.80E-10 0.409717269 p.(S399H) 0.503407171 5.31E-104 0.518861286 p.(S399I) 0.37890781 7.64E-44 1.022230853 p.(S399L) 0.377032912 1.07E-87 0.881857796 p.(S399K) 0.384384589 8.38E-10 0.962816279 p.(S399M) 0.332239244 6.71E-41 1.348361712 p.(S399F) 0.221828377 3.78E-33 1.274182306 p.(S399P) 0.136342841 2.10E-81 0.237292017 p.(S399S) 0.422640016 2.29E-35 1.065378644 p.(S399T) 0.344272305 3.30E-10 0.937924445 p.(S399W) 0.424734344 1.03E-89 0.047226451 p.(S399Y) 0.590073156 2.31E-11 0.331070059 p.(S399V) 0.356699508 3.01E-30 0.772374046 p.(S406A) 0.322204694 0.00042991 0.928466979 p.(S406R) 0.643911042 9.69E-21 0.313242116 p.(S406N) 0.453016789 3.03E-08 0.846832775 p.(S406D) 0.387955989 4.34E-06 0.909798794 p.(S406C) 0.484886613 3.32E-08 0.969066543 p.(S406Q) 0.191791224 2.14E-15 1.403865086 p.(S406E) 0.841111456 0 2.04538056 p.(S406G) 0.302709254 9.05E-64 0.71744291 p.(S406H) 0.463373694 2.21E-12 0.762134229 p.(S406I) 0.506450355 2.30E-40 0.632527809 p.(S406L) 0.750080554 4.44E-16 1.002238342 p.(S406K) 0.541443469 1.27E-08 -0.001587847 p.(S406M) 0.359050604 1.54E-16 1.336133991 p.(S406F) 0.505178284 5.69E-16 -0.019268391 p.(S406P) 0.449234102 4.20E-39 1.11607884 p.(S406S) 0.325114423 0.000923701 1.231737286 p.(S406W) 0.081049925 6.00E-56 0.503375239 p.(S406Y) 0.49835804 0.000333896 0.360439927 p.(S406V) 0.54437537 2.91E-13 0.699693918 p.(S408A) 0.48844627 2.70E-58 0.643997145 p.(S408R) 0.343274608 1.89E-21 0.582635474 p.(S408N) 0.231764842 0.000189154 -0.348618623 p.(S408D) 0.421176558 5.17E-08 1.720238781 p.(S408C) 0.318773638 3.12E-45 0.979053125 p.(S408Q) 0.544761342 2.16E-23 1.268202499 p.(S408E) 1.024264575 4.44E-16 1.931315246 p.(S408G) 0.109023665 5.45E-67 0.517569269 p.(S408H) 0.38371063 7.89E-10 0.880565316 p.(S408I) 0.449857301 5.48E-78 0.648089923 p.(S408L) 0.259147609 1.90E-11 0.672279696 p.(S408K) 0.219588465 2.20E-50 1.087504261 p.(S408M) 0.403852694 2.91E-22 1.24568888 p.(S408F) 0.414552533 1.95E-10 0.246662163 p.(S408P) 0.477961964 1.97E-33 1.497665291 p.(S408T) 0.589987125 2.11E-39 0.620999638 p.(S408W) 0.627719863 2.59E-74 0.132999147 p.(S408Y) 0.713434123 7.26E-38 0.157409495 p.(S408V) 0.32400488 5.65E-65 1.330204997 p.(S411A) 0.481456202 2.14E-09 1.529112303 p.(S411R) 0.445723076 1.06E-63 0.461620609 p.(S411N) 0.69479248 6.66E-16 1.010318044 p.(S411D) 0.355923758 8.35E-43 1.436713344 p.(S411C) 0.202907672 3.61E-23 0.620852395 p.(S411Q) 0.498105654 1.59E-82 0.78088563 p.(S411E) 0.414368501 4.47E-45 0.874116866 p.(S411G) 0.500420524 2.01E-07 1.345530285 p.(S411H) 0.850297164 4.21E-45 -0.030253143 p.(S411I) 0.600829438 8.35E-45 0.141871284 p.(S411L) 0.653952796 7.33E-15 0.387342478 p.(S411K) 0.650179828 7.07E-18 0.537393013 p.(S411M) 0.165940177 1.32E-62 0.754949242 p.(S411F) 0.168273988 1.27E-07 0.02372525 p.(S411P) 0.710654696 3.04E-67 0.503072332 p.(S411T) 0.323648648 5.15E-21 1.093211477 p.(S411W) 0.949438607 8.40E-41 -0.34066532 p.(S411Y) 0.179589966 5.70E-14 -0.950915584 p.(S411V) 0.426579327 1.48E-11 0.998132233 p.(S422A) 0.511608865 1.81E-52 1.318454488 p.(S422R) 0.405828 1.99E-130 0.016404994 p.(S422N) 0.269990013 8.06E-50 1.223503444 p.(S422D) 0.547996552 1.08E-33 0.921937878 p.(S422C) 0.894757565 6.44E-32 0.528389914 p.(S422Q) 0.301120665 5.79E-20 1.325961596 p.(S422E) 0.36448485 7.00E-26 1.628370836 p.(S422G) 0.198533886 1.87E-05 -0.196107381 p.(S422H) 0.598459344 9.21E-54 0.225291558 p.(S422I) 0.626788569 8.96E-07 0.656429989 p.(S422L) 0.73092657 1.86E-84 -0.191636321 p.(S422K) 0.271389726 7.90E-34 0.050552773 p.(S422M) 0.930791573 2.05E-32 0.565821897 p.(S422F) 0.437638924 1.45E-44 0.62973857 p.(S422P) 0.316739553 1.07E-13 0.83149432 p.(S422S) 0.537599574 4.81E-51 1.3406751 p.(S422T) 0.39081236 6.31E-69 0.423157571 p.(S422W) 0.552882864 6.52E-41 0.426756178 p.(S422Y) 0.450260304 1.73E-68 0.643155452 p.(S422V) 0.513338668 5.74E-59 0.06168465 p.(S434A) 0.646088396 0.005361128 0.99620473 p.(S434R) 0.725678869 6.66E-16 2.087844338 p.(S434N) 0.275321368 1.45E-46 -0.276865816 p.(S434D) 0.737424055 1.88E-09 3.772918488 p.(S434C) 0.295750239 1.75E-07 -0.135504567 p.(S434Q) 0.237568234 1.12E-05 0.680345902 p.(S434E) 0.802217945 7.23E-07 2.334750341 p.(S434G) 1.050892429 7.69E-13 1.317615995 p.(S434H) 0.602399322 9.90E-08 0.968512217 p.(S434I) 0.320912113 7.52E-15 0.194290365 p.(S434L) 0.695611832 2.76E-66 0.731651522 p.(S434K) 0.214491534 8.52E-60 0.060957169 p.(S434M) 0.614146878 2.05E-41 0.551667486 p.(S434F) 0.031267257 1.15E-28 0.519462879 p.(S434P) 0.55884405 4.76E-34 1.383957775 p.(S434S) 0.607828395 0 1.807036502 p.(S434W) 0.826460369 0 0.5169516 p.(S434Y) 0.84939175 0.00095519 0.57447084 p.(S434V) 0.57767484 3.77E-15 0.923809207 p.(T391A) 0.341556778 5.55E-17 -0.232275778 p.(T391R) 0.609697257 7.49E-64 -0.004872775 p.(T391N) 0.30424261 4.43E-20 -0.313605529 p.(T391D) 0.595266021 1.11E-16 2.306263211 p.(T391C) 0.33460126 1.51E-88 0.571156675 p.(T391Q) 0.243334491 0.000225723 0.830302315 p.(T391E) 0.51608779 1.67E-16 1.519136558 p.(T391G) 0.386538177 4.70E-10 1.443261248 p.(T391H) 0.512216976 5.64E-14 0.457462094 p.(T391I) 0.099485799 8.10E-06 -0.377788025 p.(T391L) 0.50890318 5.40E-44 0.031214448 p.(T391K) 0.087789919 4.68E-21 -0.231984202 p.(T391M) 0.641799405 2.58E-69 0.330110953 p.(T391F) 0.500991907 4.36E-45 0.915652052 p.(T391P) 0.204531096 5.01E-16 1.074193136 p.(T391S) 0.355321465 2.97E-06 1.010142078 p.(T391T) 0.262937587 7.80E-07 -0.044349527 p.(T391W) 0.221463968 1.05E-15 0.125626946 p.(T391Y) 0.575192971 4.32E-110 0.773303339 p.(T391V) 0.308440166 7.32E-20 0.698053846 p.(T407A) 0.084415356 2.30E-31 -0.327240727 p.(T407R) 0.591169767 5.53E-13 0.759228182 p.(T407N) 0.119765277 3.92E-22 -0.807825942 p.(T407D) 0.899382953 0 1.554128594 p.(T407C) 0.470222506 6.45E-28 0.823668048 p.(T407Q) 0.496589068 4.61E-08 0.387977054 p.(T407E) 0.431660827 0.00207987 1.115257162 p.(T407G) 0.466467761 2.15E-15 1.410159864 p.(T407H) 0.395011219 1.03E-26 0.534750343 p.(T407I) 0.371710534 8.06E-20 0.905752712 p.(T407L) 0.295239838 1.15E-125 0.123918534 p.(T407K) 0.790984845 0 1.051588695 p.(T407M) 0.062731451 1.53E-58 0.33046017 p.(T407F) 0.986656252 7.15E-46 -0.25328629 p.(T407P) 0.427473649 1.46E-44 0.32345555 p.(T407S) 0.512977325 1.39E-41 0.536535692 p.(T407T) 0.193778507 1.84E-20 -0.34556333 p.(T407W) 0.573753269 3.63E-76 0.380886239 p.(T407Y) 0.350617935 1.12E-39 0.604540647 p.(T407V) 0.573633353 1.85E-31 0.21584795 p.(T409A) 0.791410295 1.16E-12 0.890700407 p.(T409R) 0.447356226 2.30E-26 1.043423605 p.(T409N) 0.103238892 1.49E-20 0.108341353 p.(T409D) 0.813881338 0 1.705012881 p.(T409C) 0.403914141 8.55E-38 1.077399659 p.(T409Q) 0.60754322 1.67E-44 0.310650343 p.(T409E) 0.69712842 0 1.7965448 p.(T409G) 0.693876998 2.43E-112 0.373463813 p.(T409H) 0.87274521 5.75E-39 -0.005167449 p.(T409I) 0.320856566 0 -0.446377984 p.(T409L) 0.60920277 2.72E-76 -0.091362692 p.(T409K) 0.4389698 7.70E-49 0.498847912 p.(T409M) 0.41304648 2.38E-31 1.357708477 p.(T409F) 0.229427748 1.67E-74 0.429808892 p.(T409P) 0.371711712 1.34E-31 0.613219528 p.(T409S) 0.562528385 5.91E-09 0.177120803 p.(T409T) 0.17114317 1.13E-28 -0.566526053 p.(T409W) 0.473473552 1.63E-19 0.487877876 p.(T409Y) 0.258317061 1.09E-75 0.462857893 p.(T409V) 0.347660769 1.56E-29 0.280832209 p.(V403A) 0.439928394 1.84E-13 1.403951069 p.(V403R) 0.43620555 3.32E-22 1.205755759 p.(V403N) 0.21587508 6.69E-62 1.174399563 p.(V403D) 0.468611197 2.85E-23 0.983275015 p.(V403C) 0.407927288 8.52E-44 0.273155572 p.(V403Q) 0.31876677 3.09E-29 1.491854028 p.(V403E) 0.38784478 3.43E-07 1.748729193 p.(V403G) 0.644382693 1.11E-16 1.346649684 p.(V403H) 0.480307449 2.85E-46 1.18216188 p.(V403I) 0.383159417 5.80E-40 1.251534776 p.(V403L) 0.300787922 1.27E-13 0.73828102 p.(V403K) 0.501091541 1.97E-12 -0.010817458 p.(V403M) 0.196254478 1.59E-09 1.221029055 p.(V403F) 0.367858369 0 -0.07071661 p.(V403P) 0.470927241 5.55E-17 0.654662178 p.(V403S) 0.497362383 2.04E-53 1.053309792 p.(V403T) 0.603218167 3.92E-71 0.125884111 p.(V403W) 0.921627131 2.79E-49 -0.304883145 p.(V403Y) 0.225277689 3.18E-18 0.278647393 p.(V403V) 0.240400705 2.09E-18 0.872282738 p.(V423A) 0.95184374 4.44E-16 2.304651545 p.(V423R) 0.241767099 8.97E-43 0.498394161 p.(V423N) 0.190014189 7.43E-53 0.968389014 p.(V423D) 0.375068724 0.0008165 1.722192566 p.(V423C) 0.612682857 8.04E-26 1.549110352 p.(V423Q) 0.490180747 3.29E-09 1.441213564 p.(V423E) 0.816452451 6.66E-16 2.168767596 p.(V423G) 0.509572034 1.11E-16 2.077246194 p.(V423H) 0.618455115 2.22E-40 0.674136338 p.(V423I) 0.66834388 1.97E-58 0.520063732 p.(V423L) 1.109283121 8.88E-16 2.121374306 p.(V423K) 0.499763199 0.000168515 0.585918929 p.(V423M) 0.427928709 1.20E-10 1.222898945 p.(V423F) 0.182496923 4.50E-08 -0.27273346 p.(V423P) 0.699879436 2.29E-12 3.224062353 p.(V423S) 0.467323849 1.03E-14 1.172698181 p.(V423T) 0.677248295 3.96E-14 1.127093074 p.(V423W) 0.131886746 6.03E-40 0.319602161 p.(V423Y) 0.294922016 5.39E-33 0.274852307 p.(V423V) 0.261595549 3.11E-05 -0.277372989 p.(S10_I11insG) 0.333125937 1.77E-24 0.057353631 p.(I11_V12insG) 0.739920223 8.22E-15 1.464062135 p.(V12_S13insG) 0.256604765 7.75E-61 1.130058058 p.(S13_S14insG) 0.66201406 0 1.102626547 p.(S14_E15insG) 0.512952182 2.92E-33 0.653754789 p.(E15_E16insG) 0.471350162 0.000129621 1.351582721 p.(D17_G18insG) 0.234770469 0.000905948 1.104413398 p.(G18_M19insG) 0.239140358 2.90E-25 0.613207575 p.(M19_K20insG) 0.698182583 1.52E-16 -0.185523649 p.(K20_L21insG) 0.318191644 0 0.10185725 p.(L21_A22insG) 0.858029822 0 1.447526152 p.(A22_T23insG) 0.753299816 2.36E-73 0.475123107 p.(T23_M24insG) 0.944147573 3.19E-43 -0.221558242 p.(M24_A25insG) 0.167538384 7.17E-10 1.958117114 p.(A25_V26insG) 1.032961451 0 1.764148065 p.(V26_A27insG) 0.778120225 0 1.475370653 p.(A27_N28insG) 0.420215274 6.88E-12 0.69238104 p.(N28_G29insG) 0.70717913 0 1.895665076 p.(G29_F30insG) 0.24036495 2.32E-23 0.858116046 p.(S3_V4insG) 0.256228993 1.39E-17 1.036871331 p.(F30_G31insG) 0.650964241 0 0.976238499 p.(G31_N32insG) 0.385379719 1.18E-09 0.918714314 p.(N32_G33insG) 0.465194828 1.49E-27 1.183924437 p.(G33_K34insG) 0.463698355 8.85E-11 1.737202426 p.(K34_S35insG) 0.6716006 5.23E-09 0.778043041 p.(S35_K36insG) 0.419380125 3.05E-16 1.888826843 p.(K36_V37insG) 0.382360505 8.15E-31 0.432949707 p.(V37_H38insG) 0.316434524 1.80E-82 -0.308193577 p.(H38_T39insG) 0.215586582 2.04E-19 0.795259445 p.(T39_R40insG) 0.508299671 1.11E-16 1.120886184 p.(V4_R5insG) 0.29736151 4.38E-09 0.285846413 p.(R40_Q41insG) 0.196859055 0 1.153793829 p.(Q41_Q42insG) 0.307591098 1.31E-27 1.072414171 p.(Q42_C43insG) 0.826152507 2.22E-16 1.896635174 p.(C43_R44insG) 0.349147963 2.37E-19 0.390644299 p.(R44_S45insG) 0.294941845 1.81E-57 0.046134395 p.(S45_R46insG) 0.377969601 3.71E-06 2.264481526 p.(R46_F47insG) 0.774632924 3.84E-177 -2.38883917 p.(F47_V48insG) 1.655190831 8.88E-16 -4.273803309 p.(V48_K49insG) 0.441445979 1.11E-16 1.327457988 p.(R5_T6insG) 0.644494091 5.60E-07 0.317062049 p.(T6_N7insG) 0.362459775 1.21E-34 0.46871676 p.(N7_R8insG) 0.554583136 3.33E-16 1.309037038 p.(R8_Y9insG) 0.604032935 3.55E-39 0.144556642 p.(Y9_S10insG) 0.380020509 0 1.169276655 p.(S10_I11insGS) 0.418118195 0.000158498 3.450848853 p.(I11_V12insGS) 1.000452837 0 3.114255138 p.(V12_S13insGS) 0.550486377 1.62E-12 1.051572669 p.(S13_S14insGS) 0.235919022 3.43E-39 0.622518485 p.(S14_E15insGS) 0.261102417 1.38E-18 0.632698621 p.(E15_E16insGS) 0.79254746 3.56E-63 -0.47108216 p.(E16_D17insGS) 0.417721552 5.38E-25 0.560078342 p.(D17_G18insGS) 0.182888114 2.49E-41 1.142776435 p.(G18_M19insGS) 0.20678312 1.18E-12 0.443580739 p.(M19_K20insGS) 0.11671387 3.89E-28 0.758186397 p.(G2_S3insGS) 0.370814858 3.45E-39 1.410268853 p.(K20_L21insGS) 0.507301678 6.96E-60 0.448175935 p.(L21_A22insGS) 0.408763484 4.58E-12 0.331540436 p.(A22_T23insGS) 0.528711679 3.27E-46 -0.198672827 p.(T23_M24insGS) 0.709186396 2.66E-83 0.694343174 p.(M24_A25insGS) 0.450735201 5.55E-17 2.289039234 p.(A25_V26insGS) 0.440875235 3.44E-06 3.821020087 p.(V26_A27insGS) 0.869972825 2.22E-16 2.939366556 p.(A27_N28insGS) 1.116664086 0 2.948210406 p.(N28_G29insGS) 0.458446864 4.78E-08 2.605738492 p.(G29_F30insGS) 0.33715141 5.22E-10 1.85495713 p.(S3_V4insGS) 0.612022763 8.97E-10 0.383761723 p.(F30_G31insGS) 0.747074429 6.66E-16 2.687387068 p.(G31_N32insGS) 0.217478996 1.56E-11 1.042265684 p.(N32_G33insGS) 0.798505567 4.44E-16 1.760089393 p.(G33_K34insGS) 0.551705682 1.22E-12 1.540641667 p.(K34_S35insGS) 0.499516481 2.99E-12 1.842749772 p.(S35_K36insGS) 0.11708123 2.81E-06 2.271508591 p.(K36_V37insGS) 0.77919896 6.66E-16 1.255112664 p.(V37_H38insGS) 0.313477766 0.001397989 1.00138833 p.(H38_T39insGS) 0.759893616 1.11E-16 0.134390482 p.(T39_R40insGS) 0.684174629 6.66E-16 1.573917291 p.(V4_R5insGS) 0.787688163 3.13E-70 -1.13919382 p.(R40_Q41insGS) 0.503848575 8.79E-14 2.106761849 p.(Q41_Q42insGS) 0.456942558 6.05E-16 1.748632269 p.(Q42_C43insGS) 0.261073385 0 1.513669711 p.(C43_R44insGS) 0.444998667 0 2.253721906 p.(R44_S45insGS) 0.613146735 0 1.138139176 p.(S45_R46insGS) 0.630167438 0 1.849182438 p.(R46_F47insGS) 0.935899566 1.85E-77 -2.376533806 p.(F47_V48insGS) 0.455654186 1.17E-11 -4.012865833 p.(V48_K49insGS) 0.686997576 3.58E-30 -3.669788584 p.(R5_T6insGS) 0.920944476 0 2.437946842 p.(T6_N7insGS) 0.357087581 2.77E-07 1.366348287 p.(N7_R8insGS) 0.465584678 8.52E-07 2.025137071 p.(R8_Y9insGS) 0.241322818 7.53E-06 0.634348366 p.(Y9_S10insGS) 1.29271271 1.78E-15 3.042029833 p.(S10_I11insGSG) 0.906544076 4.44E-16 2.731891245 p.(I11_V12insGSG) 0.913823982 0 2.817559191 p.(V12_S13insGSG) 0.311757304 3.25E-24 -0.07335267 p.(S13_S14insGSG) 0.348753303 5.55E-17 1.125162784 p.(S14_E15insGSG) 0.237789469 2.31E-17 1.089942719 p.(E15_E16insGSG) 0.586464966 1.86E-64 1.032485201 p.(E16_D17insGSG) 0.664329191 9.91E-08 0.519289666 p.(D17_G18insGSG) 0.550192378 1.28E-82 0.839651708 p.(M19_K20insGSG) 0.766010658 4.63E-27 0.116927005 p.(G2_S3insGSG) 0.527942539 6.03E-61 -0.486201553 p.(K20_L21insGSG) 0.220358994 2.02E-31 1.257369955 p.(L21_A22insGSG) 0.067998617 2.06E-41 1.809346492 p.(A22_T23insGSG) 0.189039239 1.04E-27 0.101963823 p.(T23_M24insGSG) 0.372376855 6.22E-18 0.059488444 p.(M24_A25insGSG) 0.318743126 1.09E-21 2.0888955 p.(A25_V26insGSG) 0.591948923 4.44E-16 2.77917096 p.(V26_A27insGSG) 0.476024499 1.63E-66 1.64134062 p.(A27_N28insGSG) 0.976581233 0 1.719810951 p.(N28_G29insGSG) 0.954251358 0 2.855852776 p.(G29_F30insGSG) 0.3105108 6.41E-54 1.863793233 p.(S3_V4insGSG) 1.468340178 2.60E-18 -0.65647258 p.(F30_G31insGSG) 0.539858699 0 1.816317557 p.(N32_G33insGSG) 1.418519952 8.88E-16 2.328578585 p.(K34_S35insGSG) 0.3637269 4.32E-62 0.879691207 p.(S35_K36insGSG) 0.674778414 0 2.454571629 p.(K36_V37insGSG) 0.172360112 4.32E-05 1.014837249 p.(V37_H38insGSG) 0.333424359 1.11E-16 0.991952183 p.(H38_T39insGSG) 0.507332957 1.11E-16 1.908058527 p.(T39_R40insGSG) 0.472173465 0 1.388657544 p.(V4_R5insGSG) 0.231077345 3.25E-08 1.733044909 p.(R40_Q41insGSG) 0.372888452 5.06E-33 1.335453588 p.(Q41_Q42insGSG) 0.37837099 8.33E-17 1.211806752 p.(Q42_C43insGSG) 0.809237063 4.44E-16 2.002290244 p.(C43_R44insGSG) 0.355890477 0.000263576 0.857493193 p.(R44_S45insGSG) 0.266863413 6.08E-15 1.936323106 p.(S45_R46insGSG) 0.46206072 2.03E-09 0.951449031 p.(R46_F47insGSG) 0.915189058 8.79E-08 -2.492212796 p.(F47_V48insGSG) 0.663445647 8.41E-06 -3.581763883 p.(V48_K49insGSG) 1.667335534 0 -4.438359226 p.(R5_T6insGSG) 0.506423284 2.52E-08 2.249203293 p.(T6_N7insGSG) 0.25461964 1.77E-12 0.893122678 p.(N7_R8insGSG) 0.68409854 3.33E-16 2.13457663 p.(R8_Y9insGSG) 0.387916554 4.08E-51 0.15399315 p.(Y9_S10insGSG) 0.395913112 1.39E-08 3.559451544 p.(K49_K50insG) 0.755388611 6.21E-42 -3.033937686 p.(K50_D51insG) 0.188068695 7.99E-05 1.21391742 p.(D51_G52insG) 0.566799593 5.20E-07 2.037179817 p.(G52_H53insG) 0.412556041 5.55E-17 1.166459337 p.(H53_C54insG) 0.072818256 1.60E-14 0.479347145 p.(C54_N55insG) 0.343213594 1.09E-11 0.540083718 p.(N55_V56insG) 0.810647872 2.44E-27 -0.659617684 p.(V56_Q57insG) 0.184622616 4.12E-84 -0.183597424 p.(Q57_F58insG) 0.32858604 3.78E-12 -0.020547708 p.(F58_I59insG) 1.141818532 9.11E-85 -0.627569892 p.(I59_N60insG) 0.631724556 1.11E-16 3.066651096 p.(N60_V61insG) 0.373166938 1.08E-15 0.364193747 p.(V61_G62insG) 0.881352081 0 1.253930158 p.(G62_E63insG) 0.460425842 8.01E-36 0.538491149 p.(E63_K64insG) 0.29875778 4.40E-07 1.354592378 p.(K64_G65insG) 0.572276878 0.001145956 1.015034392 p.(G65_Q66insG) 0.647256155 5.59E-06 0.922964158 p.(Q66_R67insG) 0.745059527 1.49E-39 -0.202496212 p.(R67_Y68insG) 0.677866018 1.77E-48 -0.165385966 p.(Y68_L69insG) 0.657063365 3.22E-17 -1.107179186 p.(L69_A70insG) 0.271252417 1.96E-43 0.464701024 p.(A70_D71insG) 0.344615501 1.09E-12 0.674509727 p.(D71_I72insG) 0.392096818 5.10E-42 0.438428354 p.(I72_F73insG) 0.43265886 9.75E-07 2.197693496 p.(F73_T74insG) 0.397984194 2.85E-13 1.299397827 p.(T74_T75insG) 0.206660035 1.26E-07 0.85195968 p.(T75_C76insG) 0.812449302 1.47E-38 0.71090953 p.(C76_V77insG) 0.337930231 3.44E-08 0.184725762 p.(V77_D78insG) 0.477282299 6.23E-07 3.564610028 p.(D78_I79insG) 0.208189633 5.69E-31 3.130727504 p.(I79_R80insG) 0.457362344 1.19E-10 4.107565731 p.(R80_W81insG) 0.734158271 0 2.838121215 p.(W81_R82insG) 0.683278653 3.49E-21 0.343602154 p.(R82_W83insG) 0.876181689 4.33E-57 -1.006090778 p.(W83_M84insG) 1.144470306 1.09E-57 0.171117208 p.(M84_L85insG) 1.135682197 1.30E-14 -0.769338793 p.(L85_V86insG) 1.106273723 4.01E-22 -2.684181154 p.(V86_I87insG) 0.792279308 5.92E-39 -0.40201536 p.(I87_F88insG) 0.79812047 0.000191143 0.300724662 p.(F88_C89insG) 1.177281663 3.32E-09 -0.347405332 p.(C89_L90insG) 0.90979149 1.76E-17 0.926100453 p.(L90_A91insG) 1.364705255 2.26E-53 -0.135648628 p.(A91_F92insG) 0.729622147 0.004397444 0.279787977 p.(F92_V93insG) 2.823255112 3.55E-15 -4.897145515 p.(V93_L94insG) 1.074504466 6.45E-44 -1.048383047 p.(L94_S95insG) 1.416795155 1.92E-54 -1.742475169 p.(S95_W96insG) 0.807953066 1.52E-38 -2.466520659 p.(W96_L97insG) 1.044407185 0 -2.823520377 p.(L97_F98insG) 1.61128637 3.55E-15 -4.261963375 p.(F98_F99insG) 0.655696242 5.22E-66 -3.780492572 p.(K49_K50insGS) 0.93133131 0 -4.203903646 p.(K50_D51insGS) 0.615251233 8.45E-60 -0.8326579 p.(D51_G52insGS) 0.059070087 6.38E-07 0.185086708 p.(G52_H53insGS) 0.768411876 4.84E-06 -1.121992074 p.(H53_C54insGS) 1.700237964 0 2.404778005 p.(C54_N55insGS) 0.818336952 9.70E-11 0.444584433 p.(N55_V56insGS) 0.676289742 9.25E-09 -1.714503987 p.(V56_Q57insGS) 0.773921709 5.56E-43 -0.843774741 p.(Q57_F58insGS) 0.435115618 4.14E-42 0.363339725 p.(F58_I59insGS) 0.78600599 5.50E-27 0.123411143 p.(I59_N60insGS) 0.810619718 0 2.440196349 p.(N60_V61insGS) 0.670640672 1.84E-20 1.24255927 p.(V61_G62insGS) 0.515976379 3.98E-06 0.319752749 p.(G62_E63insGS) 0.268123003 2.25E-12 -0.011592283 p.(E63_K64insGS) 0.442713784 1.11E-16 2.018848884 p.(K64_G65insGS) 0.270881539 9.78E-13 0.099428074 p.(G65_Q66insGS) 0.618042927 6.19E-65 -0.245982511 p.(Q66_R67insGS) 0.906275191 0 0.570351749 p.(R67_Y68insGS) 0.544901106 6.75E-08 0.526830702 p.(Y68_L69insGS) 0.462756951 1.43E-36 -1.091936415 p.(L69_A70insGS) 0.458630953 6.07E-23 0.51170474 p.(A70_D71insGS) 0.712198263 4.04E-06 1.45466322 p.(D71_I72insGS) 1.04499749 4.44E-16 -0.424268639 p.(I72_F73insGS) 0.349543778 1.30E-21 1.484141451 p.(F73_T74insGS) 1.037443174 8.88E-16 2.7389586 p.(T74_T75insGS) 0.244129822 1.41E-34 0.035209156 p.(T75_C76insGS) 0.416009639 2.78E-17 1.12074717 p.(C76_V77insGS) 0.584243543 1.16E-65 0.922923556 p.(V77_D78insGS) 0.559459929 3.96E-22 1.481522372 p.(D78_I79insGS) 0.689250713 2.22E-16 2.685154217 p.(I79_R80insGS) 0.720549815 0 2.375475922 p.(R80_W81insGS) 0.977052508 0 3.611088904 p.(W81_R82insGS) 1.312719396 9.23E-53 -0.232098387 p.(R82_W83insGS) 1.289158968 1.60E-19 1.652009475 p.(W83_M84insGS) 0.533286378 5.92E-14 4.539047396 p.(M84_L85insGS) 1.033140162 8.88E-16 2.244993538 p.(L85_V86insGS) 1.436767981 1.33E-15 -2.567286332 p.(V86_I87insGS) 0.66637964 2.45E-33 0.984489256 p.(I87_F88insGS) 0.566417325 5.16E-29 1.363263197 p.(F88_C89insGS) 0.70430501 2.66E-15 2.89390175 p.(C89_L90insGS) 1.00277362 1.28E-84 0.002032998 p.(L90_A91insGS) 1.064286612 0 0.564905409 p.(A91_F92insGS) 1.392936265 2.42E-45 -1.380021631 p.(F92_V93insGS) 1.334388761 7.88E-33 -1.649851262 p.(V93_L94insGS) 0.395009783 7.29E-42 -4.659942469 p.(L94_S95insGS) 0.519901454 3.87E-74 -3.282440003 p.(S95_W96insGS) 0.77076729 2.32E-07 -3.048785871 p.(W96_L97insGS) 1.738645083 1.78E-15 -3.886755206 p.(L97_F98insGS) 0.816276816 3.36E-25 -3.377577786 p.(F98_F99insGS) 0.63852644 8.39E-71 -3.34542521 p.(K49_K50insGSG) 0.722680831 0 -5.257366453 p.(K50_D51insGSG) 1.353022779 8.42E-06 0.094981613 p.(D51_G52insGSG) 0.538890832 1.25E-51 -0.557531835 p.(G52_H53insGSG) 0.64717624 7.30E-21 -0.550902726 p.(H53_C54insGSG) 1.187523582 1.30E-24 -1.818684558 p.(C54_N55insGSG) 1.105101694 2.79E-11 -2.965429733 p.(N55_V56insGSG) 0.275349728 3.55E-23 -2.733652805 p.(V56_Q57insGSG) 0.402399882 8.04E-40 -2.664301879 p.(Q57_F58insGSG) 0.80455123 1.02E-11 0.662321253 p.(F58_I59insGSG) 0.680013477 1.20E-30 1.027030325 p.(I59_N60insGSG) 1.040072006 4.44E-16 2.517080627 p.(N60_V61insGSG) 0.605948444 1.61E-15 1.538230511 p.(V61_G62insGSG) 0.564739993 6.18E-56 -0.419232682 p.(E63_K64insGSG) 0.474690331 2.92E-25 0.433649373 p.(K64_G65insGSG) 0.546933663 1.11E-16 1.016923038 p.(G65_Q66insGSG) 0.835497013 1.21E-30 0.455642573 p.(Q66_R67insGSG) 0.578498224 1.29E-11 0.939765626 p.(R67_Y68insGSG) 0.861219555 4.94E-33 0.250001079 p.(Y68_L69insGSG) 0.499338257 7.40E-105 0.65104195 p.(L69_A70insGSG) 0.407501726 2.11E-16 1.141175841 p.(A70_D71insGSG) 0.448131479 6.60E-09 1.264172745 p.(D71_I72insGSG) 1.148231528 0 -0.328580999 p.(I72_F73insGSG) 1.368513449 0 1.559828137 p.(F73_T74insGSG) 1.551309994 0 1.997822712 p.(T74_T75insGSG) 0.259095861 2.75E-07 4.040924182 p.(T75_C76insGSG) 0.406809914 8.64E-33 3.077323854 p.(C76_V77insGSG) 0.439424155 2.42E-41 2.346861369 p.(V77_D78insGSG) 0.543651526 5.00E-23 0.847878616 p.(D78_I79insGSG) 0.582396036 4.83E-12 3.441838663 p.(I79_R80insGSG) 0.782160847 4.04E-16 0.521670998 p.(R80_W81insGSG) 0.449362473 1.21E-12 1.199961378 p.(W81_R82insGSG) 1.09349486 1.16E-66 0.191263749 p.(R82_W83insGSG) 0.858120527 8.07E-42 0.361749312 p.(W83_M84insGSG) 0.883672102 6.27E-05 -0.07321765 p.(M84_L85insGSG) 0.519394001 9.07E-33 -0.10869132 p.(L85_V86insGSG) 0.555295826 3.79E-15 0.614876811 p.(V86_I87insGSG) 0.809338701 7.91E-55 -0.593438493 p.(I87_F88insGSG) 1.057064112 5.40E-09 0.25374378 p.(F88_C89insGSG) 0.877990311 1.44E-84 -1.284152718 p.(C89_L90insGSG) 1.96827699 0 -3.340542084 p.(L90_A91insGSG) 1.394228288 5.62E-45 -1.77990628 p.(A91_F92insGSG) 1.586641481 1.85E-61 -1.482330073 p.(F92_V93insGSG) 0.508187462 0.000216624 -3.414156702 p.(V93_L94insGSG) 0.698058921 1.16E-20 -3.063778684 p.(L94_S95insGSG) 0.673493066 2.39E-26 -3.877204113 p.(S95_W96insGSG) 1.414179994 0 -3.04727446 p.(W96_L97insGSG) 1.134082892 0.000141165 -2.097940529 p.(L97_F98insGSG) 0.331639982 1.19E-24 -4.160683143 p.(F98_F99insGSG) 0.507435902 2.92E-12 -4.922145856 p.(G100_C101insG) 0.74373184 0.00421725 -3.334656364 p.(C101_V102insG) 1.056970739 0 -3.999953386 p.(V102_F103insG) 0.770764453 3.09E-88 -3.576633707 p.(F103_W104insG) 1.204576842 0 -3.580252985 p.(W104_L105insG) 0.848549776 6.46E-12 -2.375095302 p.(L105_I106insG) 0.663110812 1.30E-44 -3.662439007 p.(I106_A107insG) 0.989769315 1.85E-27 -1.741960057 p.(A107_L108insG) 1.079338207 5.18E-44 -2.336797082 p.(L108_L109insG) 1.20359389 7.43E-39 -1.827756648 p.(L109_H110insG) 0.807094 5.93E-07 -2.550444547 p.(H110_G111insG) 0.828040409 3.24E-05 -2.921507334 p.(D112_L113insG) 1.396013059 0 -2.209974016 p.(L113_D114insG) 0.566026417 4.60E-19 1.337416074 p.(D114_T115insG) 0.452723701 0 1.080705624 p.(T115_D116insG) 0.781352386 0 1.485536652 p.(D116_Y117insG) 0.341788318 1.80E-07 0.208477687 p.(Y117_K118insG) 1.096214325 0 -5.307598701 p.(K118_D119insG) 0.749210513 0.001631127 -3.041884234 p.(D119_D120insG) 0.887343917 0 -4.711871764 p.(D120_D121insG) 0.299838324 5.52E-15 -1.101429915 p.(D121_D122insG) 0.599781976 9.13E-27 -3.926906494 p.(D122_K123insG) 1.542823668 0 -3.380337225 p.(K123_S124insG) 0.981339305 0 2.278108459 p.(S124_K125insG) 0.445462243 1.23E-31 -0.064719713 p.(K125_V126insG) 0.658352803 0 1.182716866 p.(V126_S127insG) 0.308802149 1.09E-05 0.706904829 p.(S127_K128insG) 0.718299829 1.33E-60 0.24324466 p.(K128_A129insG) 0.490921402 1.35E-17 -0.544441491 p.(A129_C130insG) 0.841882549 7.66E-89 -0.187542228 p.(C130_V131insG) 0.823129468 2.07E-16 -2.458284206 p.(V131_S132insG) 1.711816531 0 -2.723431235 p.(S132_E133insG) 0.902429566 2.81E-06 -3.082684943 p.(E133_V134insG) 0.749992408 1.13E-18 -3.637266798 p.(V134_N135insG) 0.879787176 1.28E-17 -2.828991957 p.(N135_S136insG) 1.015215172 0 -3.02433892 p.(S136_F137insG) 0.868921194 1.02E-62 -2.522796404 p.(F137_T138insG) 0.505266823 2.43E-24 -2.154168144 p.(T138_A139insG) 0.675552534 2.47E-08 -4.27622982 p.(A139_A140insG) 1.084098685 2.58E-11 -3.925270826 p.(A140_F141insG) 1.229806698 0 -3.75946322 p.(F141_L142insG) 0.688694944 1.09E-55 -2.717820289 p.(L142_F143insG) 0.972978858 5.08E-14 -3.481590798 p.(F143_S144insG) 0.860310249 8.55E-21 -3.264776306 p.(S144_I145insG) 0.94353925 8.88E-16 -4.17260103 p.(I145_E146insG) 0.715775969 1.25E-13 -3.016512335 p.(E146_T147insG) 1.386808892 7.08E-60 -1.846639802 p.(T147_Q148insG) 0.675130933 3.88E-16 -2.849752536 p.(F99_G100insG) 1.367971011 1.78E-15 -4.432272986 p.(G100_C101insGS) 0.344564317 6.24E-44 -3.974677377 p.(C101_V102insGS) 0.46146142 1.04E-44 -3.660957099 p.(V102_F103insGS) 1.337629566 0 -3.720127929 p.(F103_W104insGS) 0.923289398 2.82E-12 -3.982179864 p.(W104_L105insGS) 0.935397135 0 -4.40083637 p.(L105_I106insGS) 0.709139432 4.21E-43 -3.069744175 p.(I106_A107insGS) 1.01945707 3.54E-45 -2.442329165 p.(A107_L108insGS) 1.098803383 7.52E-08 -0.994405684 p.(L108_L109insGS) 1.813526007 1.42E-33 -0.052570989 p.(L109_H110insGS) 1.383617301 1.92E-88 -0.280598477 p.(H110_G111insGS) 1.358634675 9.24E-97 -1.72439734 p.(G111_D112insGS) 1.019548218 1.84E-13 -1.425526227 p.(D112_L113insGS) 0.445577063 1.02E-37 -1.398336571 p.(L113_D114insGS) 0.229098861 2.09E-37 1.1756543 p.(D114_T115insGS) 0.889017819 2.22E-16 0.790501984 p.(T115_D116insGS) 0.751298848 2.22E-16 0.887341513 p.(D116_Y117insGS) 0.441540984 2.09E-34 1.309112661 p.(Y117_K118insGS) 1.330046385 0 -3.972854628 p.(K118_D119insGS) 0.953744875 2.22E-16 -4.292274642 p.(D119_D120insGS) 1.056382222 4.44E-16 -4.548100068 p.(D120_D121insGS) 0.692314485 4.21E-27 -3.719760308 p.(D121_D122insGS) 0.4380985 1.64E-63 -4.379649184 p.(D122_K123insGS) 0.250101919 0.001306488 -4.992800884 p.(K123_S124insGS) 1.190306133 1.33E-15 2.312652356 p.(K125_V126insGS) 0.830768128 9.47E-26 0.167823423 p.(V126_S127insGS) 0.316081597 2.46E-27 1.625280221 p.(K128_A129insGS) 0.675834075 3.29E-29 -0.756010002 p.(A129_C130insGS) 0.715762311 1.25E-39 0.247192052 p.(V131_S132insGS) 1.482615259 1.82E-08 -2.953099941 p.(E133_V134insGS) 1.195387606 1.99E-13 -2.440689786 p.(V134_N135insGS) 0.760819538 1.85E-09 -5.031215133 p.(N135_S136insGS) 0.835812924 5.95E-24 -1.357111218 p.(F137_T138insGS) 0.920452329 5.40E-129 -2.654036743 p.(T138_A139insGS) 0.682544593 6.56E-20 -3.804008184 p.(A139_A140insGS) 0.905760317 6.66E-16 -4.12710541 p.(A140_F141insGS) 1.199226872 5.31E-12 -3.955564068 p.(F141_L142insGS) 0.98456774 5.82E-22 -2.707816679 p.(L142_F143insGS) 0.660108718 1.45E-22 -3.293279028 p.(F143_S144insGS) 0.888765512 2.93E-14 -4.39412878 p.(S144_I145insGS) 1.0261003 2.49E-12 -1.398175557 p.(I145_E146insGS) 0.733482225 1.29E-40 -3.240510847 p.(E146_T147insGS) 1.544166094 7.50E-64 -1.523447533 p.(T147_Q148insGS) 1.463535958 1.63E-80 -1.729604053 p.(F99_G100insGS) 1.770679118 1.78E-15 -3.974844674 p.(G100_C101insGSG) 0.510319094 8.43E-06 -4.76318278 p.(C101_V102insGSG) 0.747070694 2.22E-16 -4.824281354 p.(V102_F103insGSG) 0.604110249 5.29E-08 -4.50115399 p.(F103_W104insGSG) 0.651810729 2.37E-27 -3.973727303 p.(W104_L105insGSG) 0.877561279 2.90E-55 -2.285646541 p.(L105_I106insGSG) 1.436699817 1.33E-15 -2.741485593 p.(I106_A107insGSG) 1.376993204 1.21E-77 -1.974713892 p.(A107_L108insGSG) 0.501441906 4.67E-64 -3.23742368 p.(L108_L109insGSG) 1.18461893 5.49E-26 -1.347825689 p.(L109_H110insGSG) 0.569095967 3.53E-07 -1.82274736 p.(H110_G111insGSG) 1.044727825 2.13E-18 -1.264594805 p.(G111_D112insGSG) 1.323328846 4.32E-12 -2.232402847 p.(D112_L113insGSG) 2.009023089 1.78E-15 -3.557684361 p.(L113_D114insGSG) 0.980007374 1.87E-35 -0.063304115 p.(D114_T115insGSG) 0.458161422 3.99E-64 1.985318401 p.(T115_D116insGSG) 0.295788491 4.13E-07 2.171890474 p.(D116_Y117insGSG) 0.311087461 7.00E-05 4.483361759 p.(Y117_K118insGSG) 1.288341159 0 -3.201685603 p.(K118_D119insGSG) 1.347010878 0 -3.737124337 p.(D119_D120insGSG) 0.693235741 0.000605454 -4.607259262 p.(D120_D121insGSG) 0.865811208 2.22E-16 -3.679477347 p.(D121_D122insGSG) 1.368519992 2.57E-07 -4.436623555 p.(D122_K123insGSG) 0.457110455 2.63E-28 -3.933046014 p.(K123_S124insGSG) 0.868862818 3.04E-39 0.436887044 p.(S124_K125insGSG) 0.488774529 1.91E-92 1.197818122 p.(K125_V126insGSG) 0.261679322 5.49E-18 0.547447629 p.(V126_S127insGSG) 0.593258317 8.60E-15 0.803447379 p.(S127_K128insGSG) 0.699680864 5.20E-95 0.446490034 p.(K128_A129insGSG) 0.768891783 2.22E-16 0.375021839 p.(A129_C130insGSG) 1.163030598 9.14E-57 -1.199498555 p.(C130_V131insGSG) 0.770786424 0 -2.297090821 p.(V131_S132insGSG) 0.733713705 2.99E-05 -3.41462647 p.(S132_E133insGSG) 0.729283364 3.76E-06 -2.898888214 p.(E133_V134insGSG) 1.146544365 4.64E-13 -0.17053224 p.(V134_N135insGSG) 0.650616733 9.24E-16 -3.363485031 p.(N135_S136insGSG) 0.652073933 4.66E-20 -3.088900547 p.(S136_F137insGSG) 1.693706293 2.66E-15 -2.569056602 p.(F137_T138insGSG) 0.502690104 1.34E-22 -3.754406898 p.(T138_A139insGSG) 0.870203826 2.55E-15 -4.12947551 p.(A139_A140insGSG) 0.856200516 0 -5.218011851 p.(A140_F141insGSG) 1.403807043 8.88E-16 -4.107600577 p.(F141_L142insGSG) 0.708814023 2.24E-18 -3.76236359 p.(L142_F143insGSG) 1.413005826 0 -3.036975588 p.(F143_S144insGSG) 0.617836243 6.82E-11 -3.558987243 p.(S144_I145insGSG) 0.497924699 3.31E-15 -5.522495788 p.(I145_E146insGSG) 1.358539302 8.88E-16 -2.284511693 p.(E146_T147insGSG) 0.866186215 1.97E-36 -1.863328433 p.(T147_Q148insGSG) 1.143298696 2.16E-39 -2.144755916 p.(F99_G100insGSG) 1.300220833 3.95E-09 -2.903833594 p.(Q148_T149insG) 1.864736609 7.47E-53 -1.217196815 p.(T149_T150insG) 0.736878867 1.50E-44 -0.337540219 p.(T150_I151insG) 0.376224981 2.78E-57 -0.3320811 p.(I151_G152insG) 0.54726754 1.35E-140 0.948172393 p.(Y153_G154insG) 0.724098921 7.94E-07 -0.039449589 p.(G154_F155insG) 0.423784316 7.83E-29 -0.115712236 p.(F155_R156insG) 0.93663026 2.22E-16 -1.275396244 p.(R156_C157insG) 0.723004846 2.04E-67 -1.252368315 p.(C157_V158insG) 1.129998808 4.70E-35 -0.971677022 p.(V158_T159insG) 1.144105695 4.27E-35 -2.252308554 p.(T159_D160insG) 0.323070337 2.57E-44 -1.424795062 p.(D160_E161insG) 0.970273956 5.00E-85 -2.693967101 p.(E161_C162insG) 0.72379483 1.93E-08 -2.732522548 p.(C162_P163insG) 0.666221549 0.025215484 -3.158989835 p.(P163_I164insG) 1.017666604 1.12E-08 -3.944463718 p.(I164_A165insG) 1.190316975 2.72E-05 -0.717466301 p.(A165_V166insG) 0.981972318 1.34E-19 -2.289878397 p.(V166_F167insG) 1.040663788 3.20E-19 -2.609291351 p.(F167_M168insG) 1.22315588 8.88E-16 -2.641129957 p.(M168_V169insG) 1.381998441 1.61E-12 -1.267020883 p.(V169_V170insG) 1.523544237 5.83E-11 -0.909517481 p.(V170_F171insG) 1.260252183 5.91E-07 -2.414710726 p.(F171_Q172insG) 0.280180862 2.07E-09 -3.870634781 p.(Q172_S173insG) 0.687274193 7.81E-05 -4.229192906 p.(S173_I174insG) 0.959819636 1.22E-49 -3.030973792 p.(I174_V175insG) 0.610948628 2.19E-19 -4.618800744 p.(V175_G176insG) 1.345267767 8.49E-40 -2.248918751 p.(G176_C177insG) 2.118893497 3.55E-15 -1.75396159 p.(C177_I178insG) 1.801916558 0 -2.002229839 p.(I178_I179insG) 1.120411846 0.023455725 -2.048237273 p.(I179_D180insG) 1.205067283 2.26E-22 -1.974835877 p.(D180_A181insG) 0.385626021 3.62E-07 2.433134495 p.(A181_F182insG) 0.347977693 1.11E-16 -1.049331594 p.(I183_I184insG) 0.46772026 5.55E-17 -0.89336662 p.(I184_G185insG) 0.603382057 0 0.200731651 p.(G185_A186insG) 1.296875675 3.26E-07 0.530779263 p.(A186_V187insG) 0.363966978 5.43E-15 -0.165743261 p.(V187_M188insG) 0.746667416 0 0.497772085 p.(M188_A189insG) 0.709226643 2.30E-10 -2.135077033 p.(A189_K190insG) 0.772889781 1.65E-30 -0.0839552 p.(K190_M191insG) 1.023350102 2.16E-138 -0.406534127 p.(M191_A192insG) 0.643193714 2.29E-35 -0.68580675 p.(A192_K193insG) 0.325405554 2.73E-12 -0.11905716 p.(K193_P194insG) 0.775613541 3.33E-09 0.509639143 p.(P194_K195insG) 0.817848112 4.89E-59 0.398124407 p.(K195_K196insG) 0.39734105 3.89E-10 0.78877815 p.(K196_R197insG) 0.475548401 2.72E-83 0.297452903 p.(Q148_T149insGS) 1.04409066 4.81E-28 -1.496877427 p.(T149_T150insGS) 0.945451684 4.66E-49 -0.288612919 p.(T150_I151insGS) 0.721506175 1.05E-61 -0.84120203 p.(I151_G152insGS) 1.045365834 7.43E-64 -0.042092387 p.(G152_Y153insGS) 0.94957422 4.39E-40 -0.977071938 p.(Y153_G154insGS) 0.686856287 3.34E-10 -0.425141195 p.(G154_F155insGS) 1.226187567 3.27E-13 -0.511224782 p.(F155_R156insGS) 1.44115288 1.33E-15 -1.925516376 p.(R156_C157insGS) 0.905266387 7.58E-19 -0.835706459 p.(C157_V158insGS) 0.753177551 2.67E-09 -0.245646378 p.(V158_T159insGS) 1.193248575 5.78E-22 -2.754329616 p.(T159_D160insGS) 0.447675648 6.35E-33 -2.928764027 p.(D160_E161insGS) 1.798858584 2.39E-57 -1.860076484 p.(E161_C162insGS) 1.167102494 2.09E-35 -2.068178784 p.(C162_P163insGS) 0.633243898 2.49E-51 -3.622499215 p.(P163_I164insGS) 0.678157495 0.002630714 -3.642963938 p.(I164_A165insGS) 1.541979832 0 -3.496922311 p.(A165_V166insGS) 1.810622063 0 -1.575921432 p.(V166_F167insGS) 0.899703327 5.66E-12 -3.263833344 p.(F167_M168insGS) 0.894145541 8.46E-09 -2.036352049 p.(M168_V169insGS) 0.723968011 1.65E-06 -3.488103574 p.(V169_V170insGS) 1.013181013 1.89E-05 -2.823860328 p.(V170_F171insGS) 0.804751358 0.002578732 -3.007679698 p.(F171_Q172insGS) 1.520310285 0 -4.228360733 p.(Q172_S173insGS) 0.690929956 1.07E-69 -2.742601737 p.(S173_I174insGS) 0.498466465 1.52E-29 -5.050325612 p.(I174_V175insGS) 0.619991971 1.42E-24 -3.423524764 p.(V175_G176insGS) 0.457484565 6.65E-52 -4.442021042 p.(G176_C177insGS) 0.812163156 0.008080582 -3.776549308 p.(C177_I178insGS) 0.817090059 6.90E-26 -2.550334147 p.(I178_I179insGS) 1.423606689 0 -2.02584432 p.(I179_D180insGS) 0.890723093 3.55E-27 -2.92045907 p.(D180_A181insGS) 1.058308725 0.004391332 -1.153969343 p.(A181_F182insGS) 2.122541574 3.30E-95 2.076459688 p.(F182_I183insGS) 0.565212314 2.77E-32 -3.921538503 p.(I183_I184insGS) 0.603635041 5.37E-10 -5.234146947 p.(I184_G185insGS) 0.404297662 3.65E-117 0.244751768 p.(G185_A186insGS) 0.497172876 9.51E-12 -0.511023965 p.(A186_V187insGS) 1.030619387 7.12E-13 -0.426620104 p.(V187_M188insGS) 1.206454232 6.10E-25 0.121001225 p.(M188_A189insGS) 0.636364643 0 0.855592402 p.(A189_K190insGS) 0.376048132 7.38E-60 0.209523633 p.(K190_M191insGS) 0.857162103 3.89E-49 -0.277299731 p.(M191_A192insGS) 0.573848793 4.70E-30 0.442658521 p.(A192_K193insGS) 0.256540983 1.13E-10 0.818477073 p.(K193_P194insGS) 0.446908072 2.10E-05 1.82670033 p.(P194_K195insGS) 0.660397363 6.66E-16 1.116152989 p.(K195_K196insGS) 0.59065915 1.14E-10 1.386086326 p.(K196_R197insGS) 1.257034404 8.88E-16 1.570493425 p.(Q148_T149insGSG) 1.795866384 2.38E-07 -0.110729899 p.(T149_T150insGSG) 0.914810481 1.19E-06 -1.330173046 p.(T150_I151insGSG) 1.124256984 0.000112827 -1.243967536 p.(I151_G152insGSG) 0.646287681 3.33E-63 -0.337922497 p.(G152_Y153insGSG) 0.772694934 1.30E-44 0.576471383 p.(Y153_G154insGSG) 0.789135448 2.98E-08 -1.263153388 p.(F155_R156insGSG) 1.040841509 7.58E-54 -1.740312725 p.(R156_C157insGSG) 1.822976729 7.79E-13 -3.29800921 p.(C157_V158insGSG) 0.928909546 1.45E-56 0.155509879 p.(V158_T159insGSG) 1.527253263 6.97E-25 -1.659580869 p.(T159_D160insGSG) 1.472157347 0 -1.260677788 p.(D160_E161insGSG) 1.319380932 2.92E-32 -2.199509041 p.(E161_C162insGSG) 0.838114551 1.39E-42 -2.688968437 p.(C162_P163insGSG) 0.420768562 4.18E-11 -4.38040628 p.(P163_I164insGSG) 0.784058797 1.06E-23 -3.149332606 p.(I164_A165insGSG) 0.698682995 0.003515983 -3.325332817 p.(A165_V166insGSG) 1.324102193 0 -2.860455765 p.(V166_F167insGSG) 0.312111819 7.37E-07 -4.569180975 p.(F167_M168insGSG) 0.815522327 5.55E-16 -4.266141032 p.(M168_V169insGSG) 0.555625942 1.80E-148 -3.403811534 p.(V169_V170insGSG) 0.617698141 7.81E-22 -3.016958142 p.(V170_F171insGSG) 1.575019866 1.57E-07 -3.335764099 p.(F171_Q172insGSG) 0.636669287 3.19E-57 -4.550929566 p.(Q172_S173insGSG) 0.769716848 7.77E-16 -4.901452157 p.(S173_I174insGSG) 0.719556571 9.51E-43 -3.681858137 p.(I174_V175insGSG) 0.802263492 4.56E-29 -3.517409673 p.(V175_G176insGSG) 0.865582025 2.82E-14 -4.03161574 p.(G176_C177insGSG) 0.506731046 4.24E-44 -5.257534556 p.(C177_I178insGSG) 0.760383472 9.25E-38 -3.391847969 p.(I178_I179insGSG) 0.920633835 0 -3.700547832 p.(I179_D180insGSG) 1.464215156 0 -1.855390629 p.(D180_A181insGSG) 1.649441302 5.44E-48 -2.303678786 p.(A181_F182insGSG) 0.588597971 0.004301451 -2.26519855 p.(F182_I183insGSG) 0.610588873 0 -1.935569878 p.(I183_I184insGSG) 0.942350893 0 -1.715185457 p.(I184_G185insGSG) 0.439101141 1.31E-48 -0.901088583 p.(A186_V187insGSG) 0.404518736 5.04E-28 0.304487319 p.(V187_M188insGSG) 0.985064813 4.44E-16 -4.338770504 p.(M188_A189insGSG) 0.744632141 2.87E-11 1.334247152 p.(A189_K190insGSG) 0.674067257 3.91E-13 0.601199735 p.(K190_M191insGSG) 0.567951487 1.45E-27 -0.202378513 p.(M191_A192insGSG) 0.658932773 1.59E-76 0.541497384 p.(A192_K193insGSG) 0.435623162 5.76E-11 0.928863714 p.(K193_P194insGSG) 0.339358408 2.37E-63 0.075398443 p.(P194_K195insGSG) 0.367694216 0.000939605 0.304979014 p.(K195_K196insGSG) 0.593478066 0 1.707982189 p.(K196_R197insGSG) 0.387053523 6.89E-14 1.549025687 p.(R197_N198insG) 1.015250638 8.88E-16 1.80044004 p.(N198_E199insG) 0.63383916 0 1.068416707 p.(E199_T200insG) 0.621070765 0 1.354924965 p.(T200_L201insG) 0.40266325 0.001782586 1.227219657 p.(L201_V202insG) 0.4761375 0 1.354230298 p.(V202_F203insG) 0.51799411 1.05E-40 1.009307643 p.(F203_S204insG) 0.50575985 0.003592274 -3.885303205 p.(S204_H205insG) 0.760708488 7.71E-78 -3.311216021 p.(H205_N206insG) 0.660907157 1.28E-64 -3.724510146 p.(N206_A207insG) 0.761485409 1.02E-05 -3.202460959 p.(A207_V208insG) 0.998545453 2.36E-05 -2.580867785 p.(V208_I209insG) 0.552055623 1.27E-71 -3.94829538 p.(I209_A210insG) 0.646019335 2.63E-08 -4.117944479 p.(A210_M211insG) 0.489019329 1.24E-32 -4.20877493 p.(M211_R212insG) 0.162338227 2.49E-103 -0.287397775 p.(R212_D213insG) 0.957305211 4.84E-58 0.166089104 p.(D213_G214insG) 1.456066256 1.33E-15 -2.450311096 p.(G214_K215insG) 1.35615193 6.59E-10 -2.432106717 p.(K215_L216insG) 0.73542729 7.81E-100 -1.986516826 p.(L216_C217insG) 0.817426976 4.57E-09 -2.937691823 p.(C217_L218insG) 1.259988295 0 -3.523019662 p.(L218_M219insG) 0.733973578 2.19E-10 -2.371945889 p.(M219_W220insG) 0.667231599 1.41E-30 -3.478231283 p.(W220_R221insG) 0.524021903 2.16E-47 -4.097576393 p.(R221_V222insG) 0.50278121 0.004537356 -4.72573422 p.(V222_G223insG) 1.078686247 2.13E-07 -0.645955349 p.(G223_N224insG) 0.832105556 3.09E-15 -0.486802874 p.(N224_L225insG) 0.328502622 9.94E-10 0.104868566 p.(L225_R226insG) 0.833407488 0 1.158054897 p.(R226_K227insG) 1.326342904 0 1.092723687 p.(K227_S228insG) 0.70034239 4.44E-16 1.126074119 p.(S228_H229insG) 0.360793547 1.10E-14 0.72003446 p.(H229_L230insG) 0.588139003 1.33E-35 0.154221821 p.(L230_V231insG) 0.553440535 2.18E-17 1.233306411 p.(V231_E232insG) 0.271612041 1.20E-10 0.355091874 p.(E232_A233insG) 0.645598131 8.02E-26 0.471050004 p.(A233_H234insG) 0.388091011 1.07E-28 0.293261173 p.(H234_V235insG) 0.458494116 1.12E-34 0.672800086 p.(V235_R236insG) 1.243282773 8.18E-17 -2.652141115 p.(R236_A237insG) 1.385782588 9.13E-104 -2.561828179 p.(A237_Q238insG) 0.330653849 5.14E-16 -3.972589409 p.(Q238_L239insG) 0.84027826 3.52E-05 -3.118363184 p.(L239_L240insG) 0.72801399 5.05E-40 -3.578604697 p.(L240_K241insG) 0.58693728 7.94E-33 1.07903385 p.(K241_S242insG) 0.325001659 0.000652407 3.243064512 p.(S242_R243insG) 0.680225995 0 1.725855422 p.(R243_I244insG) 0.504950761 5.36E-08 1.221856937 p.(I244_T245insG) 0.277073368 1.93E-37 2.73945712 p.(R197_N198insGS) 0.43634478 2.97E-54 0.204069444 p.(N198_E199insGS) 0.283409559 8.06E-31 1.660474011 p.(E199_T200insGS) 0.067337305 1.80E-87 1.032538021 p.(T200_L201insGS) 0.687639439 0 2.463355828 p.(L201_V202insGS) 0.590806664 1.11E-16 0.236842934 p.(V202_F203insGS) 0.986955066 2.31E-40 -0.157758991 p.(F203_S204insGS) 0.692995644 8.92E-98 -3.341899199 p.(S204_H205insGS) 0.593607411 4.66E-18 -4.375172118 p.(H205_N206insGS) 0.907564121 1.80E-12 -5.443133174 p.(N206_A207insGS) 1.043189595 4.44E-16 -3.000316646 p.(A207_V208insGS) 1.190098804 4.62E-08 -3.067637286 p.(V208_I209insGS) 0.824556495 0 -4.731248168 p.(I209_A210insGS) 0.667213076 4.01E-29 -3.880412486 p.(A210_M211insGS) 0.655024601 5.85E-06 -4.276509888 p.(M211_R212insGS) 1.306152122 0 -3.453676173 p.(R212_D213insGS) 1.044259616 1.20E-08 -3.813162616 p.(D213_G214insGS) 1.035985965 7.40E-16 -2.359780701 p.(G214_K215insGS) 1.223101698 1.89E-28 -0.976526999 p.(K215_L216insGS) 1.228996745 4.44E-16 -2.654775749 p.(L216_C217insGS) 0.688391612 5.18E-17 -3.247924151 p.(C217_L218insGS) 1.004377493 0 -2.567930684 p.(L218_M219insGS) 0.415867657 3.60E-16 -4.334036445 p.(M219_W220insGS) 0.532896765 4.25E-37 -4.399014684 p.(W220_R221insGS) 1.515193367 0 -2.920481678 p.(R221_V222insGS) 1.151090646 1.04E-14 -3.274726129 p.(V222_G223insGS) 0.79740819 1.61E-58 -0.049191372 p.(G223_N224insGS) 1.306047254 9.93E-71 -1.058201003 p.(N224_L225insGS) 1.143711554 4.38E-43 -0.267956336 p.(L225_R226insGS) 0.864704806 1.12E-74 0.288473135 p.(R226_K227insGS) 0.212579372 1.81E-09 0.934233423 p.(K227_S228insGS) 0.721983694 1.19E-25 0.468015342 p.(H229_L230insGS) 0.600690147 1.68E-106 -0.148005764 p.(L230_V231insGS) 0.426023592 6.55E-45 -0.800915881 p.(V231_E232insGS) 0.390906074 1.54E-24 -0.179286872 p.(E232_A233insGS) 0.47898837 2.85E-17 0.389393596 p.(A233_H234insGS) 1.243148936 9.11E-21 1.027400643 p.(H234_V235insGS) 1.144737118 3.01E-59 -0.515161023 p.(V235_R236insGS) 1.704633641 1.78E-15 -2.779301858 p.(R236_A237insGS) 1.078229826 1.86E-65 -1.907459566 p.(A237_Q238insGS) 0.701924459 0.005339873 -3.551187767 p.(Q238_L239insGS) 1.157581053 8.95E-69 -2.273597393 p.(L239_L240insGS) 1.275788887 4.88E-09 -2.942246282 p.(L240_K241insGS) 0.738655572 4.38E-30 -0.262897844 p.(K241_S242insGS) 1.352114127 0 3.233540464 p.(S242_R243insGS) 0.971328962 8.88E-16 2.460240673 p.(R243_I244insGS) 0.290820268 5.55E-09 0.889403424 p.(I244_T245insGS) 0.587818683 0 3.388916061 p.(R197_N198insGSG) 0.508578981 1.19E-08 0.807379404 p.(N198_E199insGSG) 0.967484147 4.44E-16 0.489491955 p.(E199_T200insGSG) 0.522705348 1.11E-16 2.181339361 p.(T200_L201insGSG) 0.277121418 2.33E-16 1.620653473 p.(L201_V202insGSG) 0.475694398 5.55E-17 0.388324368 p.(V202_F203insGSG) 0.62584294 1.70E-25 -3.230863915 p.(F203_S204insGSG) 0.568642593 4.51E-08 -5.374405652 p.(S204_H205insGSG) 0.931676044 1.44E-10 -3.452107562 p.(H205_N206insGSG) 0.590394075 2.22E-29 -3.514051226 p.(N206_A207insGSG) 0.771998758 1.74E-79 -3.215552615 p.(A207_V208insGSG) 1.310019944 4.44E-16 -3.288611454 p.(V208_I209insGSG) 0.566516046 5.78E-37 -3.16564355 p.(I209_A210insGSG) 0.723540502 8.93E-11 -2.64446067 p.(A210_M211insGSG) 0.604066788 8.59E-16 -2.785736749 p.(M211_R212insGSG) 0.975882904 6.18E-10 -3.712990278 p.(R212_D213insGSG) 1.030347587 1.52E-42 -3.271289754 p.(D213_G214insGSG) 0.841944826 2.06E-50 -3.119829003 p.(G214_K215insGSG) 1.031194937 1.97E-32 -2.153514477 p.(K215_L216insGSG) 1.13843574 4.31E-68 -0.057641178 p.(L216_C217insGSG) 0.515238743 1.33E-06 -4.213791533 p.(C217_L218insGSG) 1.081843549 6.60E-09 -2.989734914 p.(L218_M219insGSG) 0.760120861 4.23E-23 -3.719958169 p.(M219_W220insGSG) 0.631966387 6.28E-05 -4.334112981 p.(W220_R221insGSG) 1.89363293 5.33E-15 -3.031718661 p.(R221_V222insGSG) 0.271761206 8.36E-43 -4.484859967 p.(V222_G223insGSG) 0.866081971 3.54E-30 -0.069138065 p.(G223_N224insGSG) 0.626507733 3.81E-29 0.04384114 p.(N224_L225insGSG) 0.887776963 2.22E-16 1.225214785 p.(L225_R226insGSG) 0.880692863 2.35E-96 -0.423252708 p.(R226_K227insGSG) 0.862194871 3.03E-39 -0.444075131 p.(K227_S228insGSG) 0.560174623 2.80E-29 0.969574252 p.(S228_H229insGSG) 0.38977236 4.27E-14 0.059681737 p.(H229_L230insGSG) 1.101030874 0 0.719406837 p.(L230_V231insGSG) 0.555465836 7.12E-07 0.267623418 p.(V231_E232insGSG) 1.393832598 9.25E-31 -0.21741412 p.(E232_A233insGSG) 0.837383456 1.97E-19 0.013331467 p.(A233_H234insGSG) 0.924481774 1.87E-25 -1.317874506 p.(H234_V235insGSG) 0.848419022 2.91E-43 -0.675746067 p.(V235_R236insGSG) 1.987289265 0 -2.593396156 p.(R236_A237insGSG) 1.366983355 0 -2.699511698 p.(A237_Q238insGSG) 1.419313409 8.88E-16 -3.929412314 p.(Q238_L239insGSG) 1.801264934 0 -4.842921411 p.(L239_L240insGSG) 0.42622322 2.47E-08 -3.280022703 p.(L240_K241insGSG) 0.746435468 1.52E-51 0.15210086 p.(K241_S242insGSG) 0.406268455 2.82E-27 0.903672517 p.(S242_R243insGSG) 0.912323037 0 3.59206586 p.(R243_I244insGSG) 0.254992049 2.17E-42 0.94896776 p.(I244_T245insGSG) 0.464192433 3.41E-10 1.425196083 p.(T245_S246insG) 0.267587529 5.60E-05 2.60399209 p.(S246_E247insG) 0.448482338 6.99E-09 0.953960978 p.(E247_G248insG) 0.511162133 0.001409486 0.985222423 p.(E249_Y250insG) 0.225945961 1.31E-10 2.615631362 p.(Y250_I251insG) 0.349464321 7.31E-45 2.058055084 p.(I251_P252insG) 0.467079443 8.29E-14 2.251864645 p.(P252_L253insG) 1.676717791 0 4.566896679 p.(L253_D254insG) 0.33422084 6.90E-15 0.457240943 p.(D254_Q255insG) 0.550669237 5.10E-17 -0.567759702 p.(Q255_I256insG) 0.31427696 1.55E-08 1.332788359 p.(I256_D257insG) 0.609307835 4.23E-06 -0.926019026 p.(D257_I258insG) 2.004544571 3.76E-33 -0.997650534 p.(I258_N259insG) 1.032905068 1.64E-21 -0.462039685 p.(N259_V260insG) 0.826349113 2.22E-87 -1.467911126 p.(V260_G261insG) 0.839879009 1.92E-73 0.023443433 p.(G261_F262insG) 1.042379076 8.57E-39 -0.990212842 p.(F262_D263insG) 0.645369343 2.22E-16 0.645073516 p.(D263_S264insG) 0.789325589 5.08E-14 0.172369569 p.(S264_G265insG) 0.386244185 1.24E-07 1.229498854 p.(G265_I266insG) 0.759408763 8.74E-21 0.03778907 p.(I266_D267insG) 0.169818207 1.48E-31 1.263200552 p.(D267_R268insG) 0.75101124 0 0.449796323 p.(R268_I269insG) 0.552477205 3.82E-73 -0.118950404 p.(I269_F270insG) 0.6174402 2.09E-56 0.273360206 p.(F270_L271insG) 0.430100018 1.23E-74 0.048276243 p.(L271_V272insG) 0.876155785 7.24E-88 -0.242320375 p.(V272_S273insG) 0.396644051 1.76E-13 0.706947882 p.(S273_P274insG) 0.530888271 0 1.647832852 p.(P274_I275insG) 0.348023443 2.76E-28 0.736692554 p.(I275_T276insG) 0.812442193 6.33E-21 -0.009281289 p.(T276_I277insG) 0.965618214 1.18E-42 -0.704750016 p.(I277_V278insG) 1.215498044 1.54E-25 -1.383592822 p.(V278_H279insG) 1.751291195 0 -4.11664867 p.(H279_E280insG) 1.411489741 0 -4.395901844 p.(E280_I281insG) 0.837356338 4.44E-16 -4.400561825 p.(I281_D282insG) 0.622726713 3.62E-09 -3.75750888 p.(D282_E283insG) 0.804063468 4.21E-07 -4.243953963 p.(E283_D284insG) 0.932901143 0 -4.600480881 p.(D284_S285insG) 0.592075521 0.000146371 -5.049864352 p.(S285_P286insG) 1.095933157 3.81E-05 -2.90550689 p.(P286_L287insG) 0.898678993 0 -3.421644421 p.(L287_Y288insG) 0.568253962 2.37E-19 -4.294269899 p.(Y288_D289insG) 0.682108891 7.12E-39 -5.0319959 p.(D289_L290insG) 0.792223659 8.26E-36 -3.321378321 p.(L290_S291insG) 0.572580451 1.58E-11 -3.976157298 p.(S291_K292insG) 0.665971153 2.09E-27 -4.322150566 p.(K292_Q293insG) 0.645556785 2.12E-79 -3.76143613 p.(T245_S246insGS) 0.207007209 2.10E-19 0.984724477 p.(S246_E247insGS) 0.596545489 0 2.220150678 p.(E247_G248insGS) 0.155582152 3.93E-19 2.501801727 p.(G248_E249insGS) 0.271507492 7.23E-08 1.707713693 p.(E249_Y250insGS) 0.728317974 0 2.225358175 p.(Y250_I251insGS) 0.515824364 9.78E-21 2.584052171 p.(I251_P252insGS) 0.947964952 4.44E-16 3.221973833 p.(P252_L253insGS) 0.577389477 5.37E-08 2.100985569 p.(L253_D254insGS) 0.598230412 2.49E-54 -0.269781733 p.(D254_Q255insGS) 0.482744817 1.15E-13 0.827444329 p.(Q255_I256insGS) 0.647578422 8.06E-26 0.049813771 p.(I256_D257insGS) 0.971386846 1.45E-32 -0.669419199 p.(D257_I258insGS) 1.109478199 1.10E-33 -2.780301764 p.(I258_N259insGS) 1.096972383 0 -2.599414304 p.(N259_V260insGS) 0.562559022 2.58E-26 -3.844147981 p.(V260_G261insGS) 0.99011369 3.49E-29 0.074214368 p.(G261_F262insGS) 1.073276274 9.92E-21 -1.349226297 p.(F262_D263insGS) 0.900104211 4.93E-48 0.396881771 p.(D263_S264insGS) 0.639065502 3.95E-13 1.187605345 p.(S264_G265insGS) 0.512502799 2.61E-60 0.404842628 p.(G265_I266insGS) 0.496549487 2.69E-17 0.949699659 p.(I266_D267insGS) 0.352654947 2.82E-07 0.525596586 p.(D267_R268insGS) 0.488001559 5.78E-28 0.824344995 p.(R268_I269insGS) 0.934957121 0 1.571952094 p.(I269_F270insGS) 0.828042587 3.74E-21 0.010493968 p.(F270_L271insGS) 0.919261693 1.28E-71 0.192981652 p.(L271_V272insGS) 0.876613439 3.37E-50 0.227448784 p.(V272_S273insGS) 0.516617801 1.56E-12 1.225435062 p.(S273_P274insGS) 0.585787502 7.24E-23 0.447131062 p.(P274_I275insGS) 0.461981708 6.90E-05 -0.160504286 p.(I275_T276insGS) 0.454872592 8.13E-72 -0.163310252 p.(T276_I277insGS) 0.844446482 1.86E-54 -2.71721822 p.(I277_V278insGS) 0.555205046 1.17E-08 -4.033311836 p.(V278_H279insGS) 0.973811279 0 -3.274274556 p.(H279_E280insGS) 0.610221895 1.05E-40 -3.797645334 p.(E280_I281insGS) 0.551334365 6.77E-05 -3.303872767 p.(I281_D282insGS) 0.73603816 7.55E-07 -3.732551955 p.(D282_E283insGS) 0.878701165 0.002085815 -2.759409557 p.(E283_D284insGS) 1.668322176 0 -2.989600029 p.(D284_S285insGS) 0.698216195 2.76E-22 -3.860406884 p.(S285_P286insGS) 0.680724715 1.90E-08 -3.513822586 p.(P286_L287insGS) 0.897203835 3.88E-53 -2.945213393 p.(L287_Y288insGS) 0.719591495 2.94E-22 -3.913625408 p.(Y288_D289insGS) 0.554222274 9.29E-13 -4.516020907 p.(D289_L290insGS) 0.636453117 1.71E-55 -4.179321205 p.(L290_S291insGS) 1.27109909 0 -4.801673991 p.(K292_Q293insGS) 0.817872452 2.22E-16 -5.046609055 p.(T245_S246insGSG) 0.54692304 1.09E-11 1.407935378 p.(S246_E247insGSG) 0.701769706 0 2.072619368 p.(E247_G248insGSG) 0.526396427 4.92E-13 1.830780744 p.(G248_E249insGSG) 0.466277798 1.67E-16 2.130664794 p.(E249_Y250insGSG) 0.609934847 8.51E-31 2.278195395 p.(Y250_I251insGSG) 0.599517542 4.49E-13 1.826761712 p.(I251_P252insGSG) 1.078835748 0 2.278904539 p.(P252_L253insGSG) 0.549598685 3.85E-07 1.98372031 p.(L253_D254insGSG) 1.076413655 6.95E-38 -0.265127131 p.(D254_Q255insGSG) 1.153101609 3.19E-41 -0.251492483 p.(Q255_I256insGSG) 0.733210391 3.30E-52 0.315369182 p.(I256_D257insGSG) 1.392755875 6.17E-31 -1.665857459 p.(D257_I258insGSG) 1.511805011 3.85E-10 -3.952322246 p.(I258_N259insGSG) 0.97578261 1.16E-10 -3.97512606 p.(N259_V260insGSG) 0.995559604 0.001142289 -3.054790857 p.(V260_G261insGSG) 0.928625114 3.51E-09 -0.790979404 p.(G261_F262insGSG) 0.875502427 6.50E-06 1.012278452 p.(F262_D263insGSG) 0.534337347 6.03E-45 -0.120559866 p.(D263_S264insGSG) 0.273382228 9.45E-37 0.715242105 p.(S264_G265insGSG) 0.420446314 2.48E-08 -0.229298165 p.(G265_I266insGSG) 0.510003544 6.36E-14 0.957106495 p.(I266_D267insGSG) 0.403791416 1.25E-22 0.107766388 p.(D267_R268insGSG) 0.383091746 5.72E-07 0.58705487 p.(R268_I269insGSG) 0.503277245 3.68E-43 0.744234392 p.(I269_F270insGSG) 0.752205749 3.77E-09 -0.565369779 p.(F270_L271insGSG) 1.085613524 1.80E-43 -0.034706789 p.(L271_V272insGSG) 0.748576807 2.70E-81 0.041106141 p.(V272_S273insGSG) 0.404432547 5.55E-17 0.448395544 p.(S273_P274insGSG) 0.625118194 2.11E-15 0.425315996 p.(P274_I275insGSG) 0.61465386 3.23E-60 -3.276568394 p.(I275_T276insGSG) 1.259316482 1.39E-67 -2.203699831 p.(T276_I277insGSG) 1.106765747 1.62E-09 -1.965627403 p.(I277_V278insGSG) 0.681404587 1.97E-39 -2.78944435 p.(V278_H279insGSG) 0.501542895 9.27E-42 -4.125481004 p.(H279_E280insGSG) 0.682009398 6.29E-07 -2.275148701 p.(E280_I281insGSG) 0.694139495 2.77E-103 -3.870845271 p.(I281_D282insGSG) 0.473584067 4.34E-37 -4.127681295 p.(D282_E283insGSG) 0.750025599 1.76E-32 -3.617549546 p.(E283_D284insGSG) 0.527972254 2.45E-20 -4.457130702 p.(D284_S285insGSG) 1.725698508 0 -4.654409389 p.(S285_P286insGSG) 0.890457647 3.70E-37 -3.141142272 p.(P286_L287insGSG) 0.809599737 0 -3.033546047 p.(L287_Y288insGSG) 0.638570235 2.59E-79 -3.978020512 p.(Y288_D289insGSG) 0.634665574 2.86E-126 -3.529164058 p.(D289_L290insGSG) 1.24986789 0 -3.709813287 p.(L290_S291insGSG) 0.774044878 1.30E-16 -2.292731724 p.(S291_K292insGSG) 0.587073938 2.18E-18 -3.707293232 p.(K292_Q293insGSG) 0.889325634 1.01E-24 -2.626951564 p.(Q293_D294insG) 0.535020106 0 -5.533481994 p.(D294_I295insG) 0.400866088 1.37E-57 -3.412099766 p.(I295_D296insG) 0.993468086 6.84E-17 -1.168573387 p.(D296_N297insG) 0.182762281 2.60E-105 -0.212199306 p.(N297_A298insG) 0.464971773 0.000503726 0.605636984 p.(A298_D299insG) 0.347133264 4.55E-38 -0.226811772 p.(D299_F300insG) 0.436819344 4.46E-51 -0.115175024 p.(F300_E301insG) 0.906321978 0.001171574 -1.678831881 p.(E301_I302insG) 0.507459595 4.06E-20 -4.634370697 p.(I302_V303insG) 0.791253827 1.08E-52 -3.193857922 p.(V303_V304insG) 1.249111817 4.29E-94 -1.412971038 p.(V304_I305insG) 0.729892035 7.36E-64 -0.496709458 p.(I305_L306insG) 0.529128228 1.87E-50 -3.380043419 p.(L306_E307insG) 0.298791966 4.20E-26 -0.377836203 p.(E307_G308insG) 0.807588316 1.17E-28 0.118265153 p.(G308_M309insG) 0.446846042 2.21E-17 -0.091262195 p.(M309_V310insG) 0.823063429 2.39E-43 0.085324542 p.(V310_E311insG) 0.708826578 1.16E-40 0.321981381 p.(E311_A312insG) 0.494668824 2.60E-12 0.536568236 p.(A312_T313insG) 0.891740427 1.96E-18 0.945692858 p.(T313_A314insG) 0.307651025 1.17E-31 0.25661063 p.(A314_M315insG) 1.441659253 0 1.02680518 p.(M315_T316insG) 0.329029863 3.24E-27 -0.122153266 p.(T316_T317insG) 0.238093475 5.65E-19 0.936497484 p.(T317_Q318insG) 0.41214734 2.06E-07 1.052677247 p.(Q318_C319insG) 0.685112248 6.49E-30 -0.35369464 p.(C319_R320insG) 0.634132135 1.98E-28 -0.107720907 p.(R320_S321insG) 0.837642759 2.70E-20 -0.053019805 p.(S321_S322insG) 0.934865588 5.46E-33 -0.691795597 p.(S322_Y323insG) 0.485944388 3.45E-47 -2.791831013 p.(Y323_L324insG) 1.260191365 8.88E-16 -3.28236892 p.(L324_A325insG) 1.392550646 4.44E-16 -4.03049044 p.(A325_N326insG) 0.680222226 0.004898283 -3.985186179 p.(N326_E327insG) 0.789435767 7.73E-10 -3.502990943 p.(E327_I328insG) 0.95345073 1.53E-14 -3.474221705 p.(I328_L329insG) 0.819417201 1.23E-10 -3.537802024 p.(L329_W330insG) 0.651438987 7.40E-36 -3.591149271 p.(W330_G331insG) 0.580139433 1.77E-79 -3.398577747 p.(G331_H332insG) 0.853564969 1.02E-18 -2.664588467 p.(H332_R333insG) 0.718925546 1.31E-54 -3.533155296 p.(R333_Y334insG) 0.732772914 3.63E-13 -4.798283171 p.(Y334_E335insG) 0.533755094 3.66E-08 -4.46359978 p.(E335_P336insG) 0.497489402 7.87E-05 -4.284033016 p.(P336_V337insG) 1.106752249 1.07E-11 0.379115419 p.(V337_L338insG) 0.870216472 0 2.294748123 p.(L338_F339insG) 0.441368678 4.11E-12 0.712021777 p.(F339_E340insG) 0.306320148 2.30E-49 0.966384162 p.(E340_E341insG) 0.504259418 1.25E-11 0.64010341 p.(Q293_D294insGS) 0.723192141 1.66E-47 -3.396836557 p.(D294_I295insGS) 1.132363775 4.31E-25 -1.537062066 p.(I295_D296insGS) 0.976081062 6.79E-85 -0.645086849 p.(D296_N297insGS) 0.576766136 7.81E-05 0.119449029 p.(N297_A298insGS) 0.933969693 8.88E-16 1.753192836 p.(A298_D299insGS) 0.186266022 4.88E-39 0.70199015 p.(D299_F300insGS) 0.830297086 1.60E-58 0.176647002 p.(F300_E301insGS) 0.652631662 3.56E-100 -3.513539428 p.(E301_I302insGS) 0.61221276 5.48E-05 -4.577052543 p.(I302_V303insGS) 0.660835341 1.11E-14 -3.207019841 p.(V303_V304insGS) 0.952275849 0.000405524 -0.920286207 p.(V304_I305insGS) 0.756832006 5.95E-06 -4.47058136 p.(I305_L306insGS) 0.837946601 8.80E-93 -2.202372462 p.(L306_E307insGS) 0.645798975 3.18E-34 -0.709685697 p.(E307_G308insGS) 0.383324472 2.78E-16 0.627389037 p.(G308_M309insGS) 0.633728416 2.25E-07 0.642174781 p.(M309_V310insGS) 0.36442683 1.24E-53 1.377922458 p.(V310_E311insGS) 0.348957573 2.39E-18 0.404078313 p.(E311_A312insGS) 0.576839933 3.34E-07 -0.227832825 p.(A312_T313insGS) 0.388581944 1.35E-13 0.47659605 p.(T313_A314insGS) 0.698615415 0.006318133 0.246658897 p.(A314_M315insGS) 0.367159811 0 0.170927125 p.(M315_T316insGS) 0.885800387 1.08E-71 0.760310419 p.(T316_T317insGS) 0.250954316 3.18E-67 -0.034898496 p.(T317_Q318insGS) 0.600485449 4.68E-93 0.279925317 p.(Q318_C319insGS) 0.519050362 1.41E-45 0.249788741 p.(C319_R320insGS) 0.943734933 3.43E-55 0.207199012 p.(R320_S321insGS) 0.276135493 4.50E-48 0.474266844 p.(S321_S322insGS) 0.917114073 3.44E-49 0.381016309 p.(S322_Y323insGS) 0.285798985 8.41E-84 0.280451222 p.(Y323_L324insGS) 0.602155607 7.03E-57 -4.269768136 p.(L324_A325insGS) 0.744296216 5.23E-58 -3.729139003 p.(A325_N326insGS) 0.991621332 2.79E-40 -1.073840306 p.(N326_E327insGS) 1.01192676 0 -2.880196553 p.(E327_I328insGS) 1.788244302 0 -3.290030397 p.(I328_L329insGS) 0.45250207 3.25E-15 -4.645848502 p.(L329_W330insGS) 0.752722391 7.28E-40 -2.658626751 p.(W330_G331insGS) 0.510356196 0.001280022 -4.841842781 p.(G331_H332insGS) 1.080370526 6.66E-16 -2.508028597 p.(H332_R333insGS) 0.902088348 1.19E-92 -2.914092497 p.(R333_Y334insGS) 1.140001113 0 -3.75864155 p.(Y334_E335insGS) 0.817681857 4.57E-31 -2.608612073 p.(E335_P336insGS) 0.934149812 1.90E-10 -2.956964199 p.(P336_V337insGS) 0.780947863 1.87E-30 -3.635980766 p.(V337_L338insGS) 0.762067264 3.55E-49 0.161348372 p.(L338_F339insGS) 0.6019661 7.76E-27 -0.675768817 p.(F339_E340insGS) 0.426727226 0 1.172139036 p.(E340_E341insGS) 0.365977905 0 1.182936986 p.(Q293_D294insGSG) 0.350776965 2.01E-31 -4.417300656 p.(D294_I295insGSG) 0.617412208 1.18E-15 -4.043968842 p.(I295_D296insGSG) 0.925753502 7.12E-12 -2.008588446 p.(D296_N297insGSG) 0.80507836 4.54E-114 -0.735953649 p.(N297_A298insGSG) 0.730964414 1.57E-61 -0.015099192 p.(A298_D299insGSG) 1.011132962 1.41E-20 -0.832820008 p.(D299_F300insGSG) 1.010543178 9.37E-19 -0.811696215 p.(F300_E301insGSG) 0.854951737 5.45E-19 -2.442066696 p.(E301_I302insGSG) 0.707016225 2.68E-05 -3.517837359 p.(I302_V303insGSG) 0.540465606 3.11E-51 -3.896772325 p.(V303_V304insGSG) 1.311823292 8.88E-16 -3.82432842 p.(V304_I305insGSG) 0.612255729 0.002664788 -3.714107191 p.(I305_L306insGSG) 0.776870068 8.42E-07 -2.813359297 p.(L306_E307insGSG) 0.980623128 5.14E-63 -0.369052796 p.(E307_G308insGSG) 0.508735163 2.79E-23 0.579067935 p.(M309_V310insGSG) 0.326306521 6.35E-57 0.527782568 p.(V310_E311insGSG) 0.268061278 1.19E-53 -0.344773578 p.(E311_A312insGSG) 0.855133922 3.51E-79 0.270787206 p.(A312_T313insGSG) 0.565241962 0 0.818442664 p.(T313_A314insGSG) 0.559077489 3.92E-46 0.699737259 p.(A314_M315insGSG) 0.442859552 8.24E-08 0.945067218 p.(M315_T316insGSG) 0.540863851 3.33E-16 1.446223188 p.(T316_T317insGSG) 0.853892756 1.75E-27 0.138059961 p.(T317_Q318insGSG) 0.618363283 3.03E-25 0.034259725 p.(Q318_C319insGSG) 0.77791173 1.67E-69 -0.502723607 p.(C319_R320insGSG) 1.151036438 0.000162821 -0.688148687 p.(R320_S321insGSG) 0.596644084 2.58E-07 -3.073223419 p.(S321_S322insGSG) 0.97724967 2.21E-13 -2.871893294 p.(S322_Y323insGSG) 0.72529151 2.57E-49 -3.539079838 p.(Y323_L324insGSG) 1.797168588 0 -2.670247877 p.(L324_A325insGSG) 0.692576308 1.20E-18 -2.539559633 p.(A325_N326insGSG) 0.834304675 9.21E-58 -2.143247715 p.(N326_E327insGSG) 1.651426555 0 -2.339382082 p.(E327_I328insGSG) 0.862421857 1.08E-61 -2.225586179 p.(I328_L329insGSG) 0.98044291 1.83E-13 -4.262522441 p.(L329_W330insGSG) 0.569035884 0.000102678 -4.607439087 p.(W330_G331insGSG) 0.758893133 1.27E-16 -3.367754843 p.(G331_H332insGSG) 0.579715869 9.03E-14 -3.939558903 p.(H332_R333insGSG) 0.566114635 0.003740858 -4.343439938 p.(R333_Y334insGSG) 0.936154284 3.64E-22 -2.010379393 p.(Y334_E335insGSG) 1.348846965 0 -3.419034294 p.(E335_P336insGSG) 0.498094113 9.21E-18 -4.300563144 p.(P336_V337insGSG) 0.683660697 2.07E-40 -3.833367615 p.(V337_L338insGSG) 0.833321619 0.000100351 -3.046587698 p.(L338_F339insGSG) 0.700883295 7.61E-30 -1.305369675 p.(F339_E340insGSG) 0.487874399 1.09E-77 -0.608911918 p.(E340_E341insGSG) 0.956950566 0 0.490665365 p.(E341_K342insG) 0.656607548 7.35E-13 0.365623259 p.(K342_H343insG) 0.235633366 6.11E-82 0.105836756 p.(H343_Y344insG) 0.5684796 1.37E-19 0.618496784 p.(Y344_Y345insG) 0.312972755 9.80E-11 -0.058677381 p.(Y345_K346insG) 1.980946085 1.78E-15 -1.860944445 p.(K346_V347insG) 0.871664474 3.63E-56 0.092663256 p.(V347_D348insG) 1.768187542 0 -2.977042463 p.(D348_Y349insG) 1.187998389 1.78E-15 -3.824901748 p.(Y349_S350insG) 0.721545645 2.74E-22 -0.775217484 p.(S350_R351insG) 1.936291978 0 -1.163175133 p.(R351_F352insG) 0.998038271 0 -2.925361709 p.(F352_H353insG) 0.723730244 3.13E-09 -2.729545743 p.(H353_K354insG) 0.942017724 4.63E-07 -3.142488966 p.(K354_T355insG) 0.618173607 5.47E-13 -3.788863178 p.(T355_Y356insG) 0.629770475 2.99E-16 -3.729631613 p.(Y356_E357insG) 1.264793721 8.88E-16 -3.074166053 p.(E357_V358insG) 0.740031531 8.22E-33 -2.500089085 p.(V358_P359insG) 0.814462779 0.000453596 -2.426288704 p.(P359_N360insG) 0.493788293 6.99E-19 -3.660803578 p.(N360_T361insG) 0.738302452 1.12E-23 -1.715451003 p.(T361_P362insG) 0.547422522 0.001552111 -3.632764843 p.(P362_L363insG) 0.636280722 1.87E-16 -2.326586826 p.(L363_C364insG) 0.761397758 1.92E-08 -3.459497514 p.(C364_S365insG) 0.619113129 2.46E-08 -3.954458612 p.(S365_A366insG) 0.791706798 6.26E-17 -3.453677712 p.(A366_R367insG) 0.677443952 4.14E-34 -3.872354159 p.(R367_D368insG) 0.347977693 1.11E-16 -1.049331594 p.(D368_L369insG) 1.040555038 4.44E-16 -4.235031862 p.(L369_A370insG) 0.673592135 6.12E-27 -0.665602397 p.(A370_E371insG) 0.508723794 9.10E-08 -1.200437102 p.(E371_K372insG) 0.645948002 5.11E-24 0.143546344 p.(K372_K373insG) 0.326822818 2.11E-45 0.778295486 p.(K373_Y374insG) 0.453210926 8.11E-24 0.857298009 p.(Y374_I375insG) 0.881520873 1.11E-15 1.479217701 p.(I375_L376insG) 0.283390269 0.000592606 0.789198149 p.(L376_S377insG) 0.37105442 1.11E-16 1.174903831 p.(S377_N378insG) 0.460495025 5.55E-17 1.477510304 p.(N378_A379insG) 0.410649616 1.89E-13 1.535402512 p.(A379_N380insG) 0.430696088 1.01E-14 0.44031615 p.(N380_S381insG) 0.66322358 0 2.196296811 p.(S381_F382insG) 0.352518939 1.15E-16 1.657848303 p.(F382_C383insG) 0.97911545 2.30E-23 -0.596148104 p.(C383_Y384insG) 0.319768681 0.001719368 1.755796828 p.(Y384_E385insG) 1.110549012 0.008367128 0.424328797 p.(E385_N386insG) 0.866084815 1.38E-60 -1.618737783 p.(N386_E387insG) 0.694812692 1.89E-27 -0.452732931 p.(E387_V388insG) 0.317638056 0.000737872 2.211817307 p.(V388_A389insG) 0.328680794 2.30E-48 2.335795794 p.(E341_K342insGS) 0.478047106 1.11E-16 1.491294612 p.(K342_H343insGS) 0.298481735 4.49E-46 -0.253762003 p.(H343_Y344insGS) 0.471996225 2.26E-87 -0.481549779 p.(Y344_Y345insGS) 0.889701342 4.91E-51 -0.645147139 p.(Y345_K346insGS) 0.545218352 3.08E-09 -3.863959505 p.(K346_V347insGS) 1.551474248 1.68E-11 -3.230680353 p.(V347_D348insGS) 0.693107838 1.16E-63 -3.225156561 p.(D348_Y349insGS) 0.498340767 2.76E-30 -3.690855841 p.(Y349_S350insGS) 0.802610982 1.11E-15 -4.188099327 p.(S350_R351insGS) 1.403229221 1.31E-07 -2.714304493 p.(R351_F352insGS) 1.596700961 1.78E-15 -3.071595435 p.(F352_H353insGS) 0.728540002 0.005376553 -3.047279801 p.(H353_K354insGS) 0.993417563 3.82E-09 -3.057997633 p.(K354_T355insGS) 0.600187157 0 -4.727225515 p.(T355_Y356insGS) 1.007665366 2.22E-16 -3.332374627 p.(Y356_E357insGS) 0.655420861 1.06E-26 -4.132583991 p.(E357_V358insGS) 0.872555807 5.13E-08 -3.100168646 p.(V358_P359insGS) 0.622409149 0.003769128 -3.780321914 p.(P359_N360insGS) 0.904428447 3.48E-110 -2.928575443 p.(N360_T361insGS) 1.307062746 1.98E-07 -2.696031744 p.(T361_P362insGS) 1.243672385 0 -3.490276282 p.(P362_L363insGS) 0.912996475 0 -4.392166674 p.(L363_C364insGS) 0.689518039 4.93E-29 -3.846612764 p.(C364_S365insGS) 0.710653623 1.03E-10 -3.069890126 p.(S365_A366insGS) 0.523615097 2.66E-52 -3.715730619 p.(A366_R367insGS) 1.281840706 8.88E-16 -5.128588485 p.(R367_D368insGS) 0.617528524 7.82E-07 -4.380148838 p.(D368_L369insGS) 1.243556031 0 -3.370633477 p.(L369_A370insGS) 1.017719261 5.95E-63 0.11987873 p.(A370_E371insGS) 0.561397507 1.97E-29 -0.345324072 p.(E371_K372insGS) 1.020544204 1.64E-39 -0.252339929 p.(K372_K373insGS) 0.251944632 3.35E-07 -0.133726921 p.(K373_Y374insGS) 0.128006231 3.74E-80 0.101332029 p.(Y374_I375insGS) 0.495762939 0 2.176599658 p.(I375_L376insGS) 0.453534033 0 0.811093369 p.(L376_S377insGS) 0.36778877 1.90E-11 1.926124491 p.(S377_N378insGS) 0.298254378 1.73E-06 1.992834517 p.(N378_A379insGS) 0.365842653 4.81E-11 1.677086948 p.(A379_N380insGS) 0.568257181 0 2.170507304 p.(N380_S381insGS) 0.423312637 3.57E-12 1.311908525 p.(S381_F382insGS) 0.22304679 1.27E-12 3.366741897 p.(F382_C383insGS) 1.067716751 1.18E-15 -0.828712574 p.(C383_Y384insGS) 0.680977533 7.60E-19 0.225389859 p.(Y384_E385insGS) 0.969206081 2.74E-41 -0.497579459 p.(E385_N386insGS) 0.710670142 1.78E-81 -1.722702702 p.(N386_E387insGS) 0.9380022 1.39E-40 0.100406749 p.(E387_V388insGS) 0.669805133 6.04E-54 2.443168338 p.(E341_K342insGSG) 0.397920896 0.000414355 1.683097416 p.(K342_H343insGSG) 0.179142741 2.18E-23 -0.407765857 p.(H343_Y344insGSG) 0.409469231 3.46E-09 -0.047062607 p.(Y344_Y345insGSG) 0.823393899 6.07E-77 -0.272086415 p.(Y345_K346insGSG) 1.039568574 1.10E-09 -3.983639113 p.(K346_V347insGSG) 0.453049119 4.71E-72 -2.497626035 p.(V347_D348insGSG) 1.069887385 0 -3.858964972 p.(D348_Y349insGSG) 0.855065075 4.44E-16 -3.063265052 p.(Y349_S350insGSG) 0.544980944 0.00254459 -4.835811675 p.(S350_R351insGSG) 0.660699128 4.84E-39 -3.184154078 p.(R351_F352insGSG) 0.419027137 1.13E-38 -4.354831812 p.(F352_H353insGSG) 0.887404724 4.82E-07 -3.351104929 p.(H353_K354insGSG) 1.357929962 0 -3.888113346 p.(K354_T355insGSG) 0.662115559 3.19E-10 -3.993659777 p.(T355_Y356insGSG) 1.322420002 8.88E-16 -3.056186487 p.(Y356_E357insGSG) 0.843281668 7.55E-47 -3.323008518 p.(E357_V358insGSG) 1.574237986 0 -3.286709674 p.(V358_P359insGSG) 0.74783094 5.09E-06 -2.666711949 p.(P359_N360insGSG) 1.516156947 8.88E-16 -3.789975634 p.(N360_T361insGSG) 0.191109551 3.72E-09 -4.404524312 p.(T361_P362insGSG) 0.839169855 1.32E-106 -2.785432192 p.(P362_L363insGSG) 0.916440092 2.69E-08 -2.742748919 p.(L363_C364insGSG) 1.078689167 0 -4.261944042 p.(C364_S365insGSG) 0.643586552 7.13E-78 -3.273127185 p.(S365_A366insGSG) 0.662572959 1.50E-17 -3.819085525 p.(A366_R367insGSG) 0.48407543 5.38E-49 -3.943400135 p.(R367_D368insGSG) 0.398551322 1.25E-41 -4.24012169 p.(D368_L369insGSG) 1.374225471 1.44E-09 -2.770638773 p.(L369_A370insGSG) 0.446386054 1.61E-85 -0.327157652 p.(A370_E371insGSG) 0.681380328 2.25E-56 -0.415426553 p.(E371_K372insGSG) 0.842279147 2.79E-28 -0.859851815 p.(K372_K373insGSG) 0.708801994 1.47E-44 -0.396241176 p.(K373_Y374insGSG) 0.51212025 9.61E-10 0.445038004 p.(Y374_I375insGSG) 0.505187872 5.96E-09 2.159504619 p.(I375_L376insGSG) 0.869069246 0 1.87738747 p.(L376_S377insGSG) 0.202538208 0.000462376 3.299401887 p.(S377_N378insGSG) 0.512619111 0 1.632020369 p.(N378_A379insGSG) 0.432550196 1.80E-10 2.022205383 p.(A379_N380insGSG) 0.473556171 5.55E-17 1.889441668 p.(N380_S381insGSG) 0.851907471 0 1.847656613 p.(S381_F382insGSG) 0.256315898 7.71E-31 1.569183452 p.(F382_C383insGSG) 1.372341176 6.47E-11 0.06010742 p.(C383_Y384insGSG) 0.629103179 6.14E-84 -0.747819869 p.(Y384_E385insGSG) 1.201282356 0.006260439 -3.480230425 p.(E385_N386insGSG) 0.828769521 6.39E-58 -0.761979353 p.(N386_E387insGSG) 1.067759302 3.32E-05 -1.256662294 p.(E387_V388insGSG) 0.443095899 2.08E-11 2.867395465 p.(V388_A389insGSG) 0.169976284 4.19E-09 3.515745337 p.(A389_L390insG) 0.53167391 0 3.280875793 p.(L390_T391insG) 0.683351613 1.11E-16 1.680390473 p.(T391_S392insG) 0.640154988 5.55E-16 1.379270466 p.(S392_K393insG) 0.226557369 4.47E-16 -0.418268759 p.(K393_E394insG) 0.438401686 6.72E-13 1.407244619 p.(E394_E395insG) 0.209481973 1.43E-11 0.981148075 p.(E395_E396insG) 0.397466159 3.94E-08 0.849266642 p.(E396_E397insG) 0.727022384 0 1.349607522 p.(E397_D398insG) 0.582913437 4.54E-07 1.713091981 p.(D398_S399insG) 0.492257698 8.72E-15 1.628399015 p.(S399_E400insG) 0.582644092 5.17E-10 1.342176687 p.(E400_N401insG) 0.547570173 4.52E-05 1.49080496 p.(N401_G402insG) 0.3906987 1.59E-27 0.744555608 p.(V403_P404insG) 0.30366232 1.26E-43 0.747261116 p.(P404_E405insG) 0.622151424 1.73E-28 0.257976227 p.(E405_S406insG) 0.435069099 7.34E-74 0.829217181 p.(S406_T407insG) 0.39218768 1.42E-34 1.07973952 p.(T407_S408insG) 0.900239744 0 1.389751174 p.(S408_T409insG) 0.567968956 1.55E-23 1.293519082 p.(T409_D410insG) 0.38303562 8.25E-68 0.673809327 p.(D410_S411insG) 0.387016152 2.16E-33 0.448734006 p.(S411_P412insG) 0.528669416 3.44E-15 0.445062257 p.(P412_P413insG) 0.695524053 4.44E-16 1.165731578 p.(P413_G414insG) 0.439393906 2.98E-08 1.746190079 p.(G414_I415insG) 0.163097189 4.68E-18 0.742436733 p.(I415_D416insG) 0.96778346 0.000340908 0.831804899 p.(D416_L417insG) 0.160455451 0.000709708 0.430023364 p.(L417_H418insG) 0.259270276 4.81E-79 0.817392929 p.(H418_N419insG) 0.613802902 7.43E-28 0.839353131 p.(N419_Q420insG) 0.278597676 2.48E-07 1.037007957 p.(Q420_A421insG) 0.423304245 4.08E-12 1.459920823 p.(A421_S422insG) 0.182524724 4.68E-09 1.11775331 p.(S422_V423insG) 0.550727877 0 1.344069854 p.(V423_P424insG) 0.533758452 9.31E-26 0.15418015 p.(P424_L425insG) 0.198333361 2.88E-117 0.397756359 p.(L425_E426insG) 0.661792296 1.15E-89 0.460593504 p.(E426_P427insG) 0.358998823 0.001621036 2.147407111 p.(P427_R428insG) 0.101508862 3.24E-88 -0.353889981 p.(R428_P429insG) 0.474044493 0 0.992908891 p.(P429_L430insG) 0.881232053 0 0.448359903 p.(L430_R431insG) 0.647020568 1.11E-16 1.4141587 p.(R431_R432insG) 0.857330596 1.30E-53 0.90553177 p.(R432_E433insG) 0.506368301 1.70E-12 0.533530226 p.(E433_S434insG) 0.719702427 4.44E-16 0.577986541 p.(S434_E435insG) 1.032028662 4.44E-16 1.711726416 p.(E435_I436insG) 0.475277863 2.37E-12 -0.091802056 p.(A389_L390insGS) 1.17182025 8.88E-16 3.90340025 p.(L390_T391insGS) 0.414036267 1.62E-09 0.85381575 p.(T391_S392insGS) 0.55795322 2.22E-16 3.141663557 p.(S392_K393insGS) 0.495677038 5.55E-17 0.782085296 p.(K393_E394insGS) 0.445199086 2.09E-06 1.707128781 p.(E394_E395insGS) 0.290731766 0.000630015 1.649003606 p.(E395_E396insGS) 0.895135711 4.44E-16 1.455054839 p.(E396_E397insGS) 1.299256823 0 2.074334882 p.(E397_D398insGS) 0.508660867 2.09E-34 1.215825711 p.(D398_S399insGS) 1.299573582 0 2.660722406 p.(S399_E400insGS) 0.736043262 4.44E-16 1.884909909 p.(E400_N401insGS) 1.041477176 0 2.168766531 p.(N401_G402insGS) 0.366870127 4.68E-20 0.340315316 p.(G402_V403insGS) 1.058751536 2.22E-16 1.42344241 p.(V403_P404insGS) 0.421184897 5.63E-10 1.227696676 p.(P404_E405insGS) 0.595936977 2.22E-16 0.812564077 p.(E405_S406insGS) 0.184921587 2.70E-39 1.070617722 p.(S406_T407insGS) 0.146360822 3.32E-24 0.713148114 p.(T407_S408insGS) 0.6230779 6.28E-05 2.06780162 p.(S408_T409insGS) 0.248311543 0.000220717 1.225921792 p.(T409_D410insGS) 0.244264416 1.01E-14 1.251933115 p.(D410_S411insGS) 0.566980461 1.41E-09 1.936111296 p.(S411_P412insGS) 0.743499873 4.13E-90 0.17230967 p.(P412_P413insGS) 0.532221463 5.28E-13 1.850984557 p.(P413_G414insGS) 0.55887181 1.55E-10 1.46284798 p.(G414_I415insGS) 0.727808436 0 1.75698292 p.(I415_D416insGS) 0.296130207 3.56E-14 0.23350546 p.(D416_L417insGS) 0.639090326 1.84E-36 0.599130189 p.(L417_H418insGS) 0.869926069 4.44E-16 0.874388313 p.(H418_N419insGS) 0.76884318 0 1.856649719 p.(N419_Q420insGS) 0.178536469 3.61E-49 1.079733327 p.(Q420_A421insGS) 0.628314486 8.59E-06 1.142272775 p.(A421_S422insGS) 0.960718536 0 1.485053695 p.(S422_V423insGS) 0.846280275 2.22E-16 0.598602219 p.(V423_P424insGS) 0.520853418 1.84E-40 0.287914678 p.(P424_L425insGS) 0.70791189 0 2.28841009 p.(L425_E426insGS) 0.616566885 1.01E-36 0.863967418 p.(E426_P427insGS) 0.3784698 1.75E-30 3.833000825 p.(P427_R428insGS) 0.534405353 1.95E-20 1.450198013 p.(R428_P429insGS) 0.660487943 0 2.880900321 p.(P429_L430insGS) 0.675457704 7.89E-08 0.835197343 p.(L430_R431insGS) 1.003133333 1.40E-20 1.953867064 p.(R431_R432insGS) 0.570980354 9.27E-41 1.223601515 p.(R432_E433insGS) 0.984030137 8.88E-16 2.635014146 p.(E433_S434insGS) 0.260913168 2.49E-44 2.088505237 p.(S434_E435insGS) 0.797563651 0 1.969565669 p.(E435_I436insGS) 0.376396217 1.55E-11 1.795094521 p.(A389_L390insGSG) 0.701254012 0 3.454224966 p.(L390_T391insGSG) 0.444451845 0 1.882639904 p.(T391_S392insGSG) 0.330904944 0.000117894 1.907019871 p.(S392_K393insGSG) 0.404727554 1.33E-51 1.214292432 p.(K393_E394insGSG) 0.393002176 6.30E-20 1.625433548 p.(E394_E395insGSG) 0.871177693 0 2.103637321 p.(E395_E396insGSG) 0.282383754 2.76E-41 1.187044929 p.(E396_E397insGSG) 0.75038845 0 2.026218307 p.(E397_D398insGSG) 0.496949235 0.000837583 2.189043767 p.(D398_S399insGSG) 0.660599998 0 1.618789591 p.(S399_E400insGSG) 0.615236648 0.001866094 2.134289123 p.(E400_N401insGSG) 0.446248301 1.42E-06 0.95314004 p.(N401_G402insGSG) 0.160438862 1.23E-13 1.124400778 p.(G402_V403insGSG) 0.775749818 1.42E-13 0.617231439 p.(V403_P404insGSG) 0.29749376 2.93E-44 1.16864382 p.(P404_E405insGSG) 0.705329989 1.12E-39 1.317831272 p.(E405_S406insGSG) 0.363972118 7.62E-72 1.902688649 p.(S406_T407insGSG) 0.953057862 8.88E-16 1.538628982 p.(T407_S408insGSG) 0.35750954 2.13E-12 2.299303877 p.(S408_T409insGSG) 0.413761442 7.50E-48 1.612215796 p.(T409_D410insGSG) 0.977104804 4.44E-16 0.894874787 p.(D410_S411insGSG) 0.840048225 2.22E-16 2.463521122 p.(S411_P412insGSG) 0.64825534 1.78E-15 0.477776917 p.(P412_P413insGSG) 0.733422816 0 1.051789086 p.(P413_G414insGSG) 0.284976352 2.98E-12 0.584414473 p.(G414_I415insGSG) 0.573407904 0 1.084521254 p.(I415_D416insGSG) 0.745339787 0 2.285908684 p.(D416_L417insGSG) 0.615648729 1.02E-42 1.246565502 p.(L417_H418insGSG) 0.575278137 3.23E-13 0.576793648 p.(H418_N419insGSG) 0.035968314 1.27E-115 0.719188604 p.(N419_Q420insGSG) 0.433664073 3.61E-05 0.991627456 p.(Q420_A421insGSG) 0.836368743 3.06E-14 1.375452149 p.(A421_S422insGSG) 0.038122691 2.84E-65 0.652732062 p.(S422_V423insGSG) 0.832786485 0 1.830609239 p.(V423_P424insGSG) 0.715093196 0 1.926214557 p.(P424_L425insGSG) 0.734136725 3.50E-55 0.925484292 p.(L425_E426insGSG) 0.303008222 2.59E-114 1.250837174 p.(E426_P427insGSG) 0.613410928 4.79E-39 0.978354929 p.(P427_R428insGSG) 0.469457451 0 -0.757201064 p.(R428_P429insGSG) 0.550991706 1.03E-08 0.889439417 p.(P429_L430insGSG) 0.591853961 0 2.016257529 p.(L430_R431insGSG) 0.973850486 0 1.268506787 p.(R431_R432insGSG) 0.459432398 1.74E-17 1.57019748 p.(R432_E433insGSG) 0.3900263 9.80E-26 2.848391212 p.(E433_S434insGSG) 0.248871071 6.80E-34 2.93778141 p.(S434_E435insGSG) 0.959738105 4.44E-16 1.644228985 p.(E435_I436insGSG) 0.674824709 9.71E-36 1.861872225 _wt 0 0 0