Overview of Sequence Annotation
Domain(s) to sequence segment[146,323]
Domain name? PDB? Length? Seq range? Score[FC/R]? FPR[FC/R]? Score[FC]? FPR[FC]? Domaincoverage? Total FPR? Hits'classification?
PF00106.20_adh_short_seed ? 1IPE|A 225 168,305 0.64 0.00 0.645 0.00 1 0 TP,TP
PF01488.15_Shikimate_DH_seed ? 1NVT|A 170 156,292 0.995 0.00 0.995 0.00 1 0 TP,TP
PF02826.14_2-Hacid_dh_C_seed ? 3ORQ|A 260 127,269 0.645 0.00 0.67 0.00 1 0 TP,TP
PF02882.14_THF_DHG_CYH_C_seed? 1A4I|A 205 131,258 0.78 0.00 0.795 0.00 1 0 FN,FN
PF03446.10_NAD_binding_2_seed? 1PGQ|A 235 167,321 0.7 0.00 0.71 0.00 1 0 FN,FN
PF03807.12_F420_oxidored_seed? 2VNS|A 123 169,268 0.975 0.00 0.98 0.00 1 0 TP,TP
PF08659.5_KR_seed ? 2VZ9|A 257 169,281 0.57 0.01 0.725 0.00 1 0.01 FN,FN
PF13241.1_NAD_binding_7_seed ? 1PJQ|A 379 162,275 0.535 0.01 0.535 0.01 1 0.02 TP,FN
PF13460.1_NAD_binding_10_seed? 1HDO|A 362 170,344 0.495 0.03 0.49 0.03 1 0.06 TP
PF01408.17_GFO_IDH_MocA_seed ? 2IXB|A 188 168,265 0.445 0.11 0.45 0.10 1 0.21 TP
PF02254.13_TrkA_N_seed ? 1LSS|A 195 170,285 0.4 0.18 0.42 0.15 1 0.33 TP
PF03949.10_Malic_M_seed ? 1DO8|A 324 146,323 0.14 0.66 0.485 0.04 1 0.7 TP
PF07991.7_IlvN_seed ? 1YVE|A 177 165,233 0.205 0.53 0.205 0.54 0.42 1.07 TP
Domain(s) to sequence segment[7,142]
Domain name? PDB? Length? Seq range? Score[FC/R]? FPR[FC/R]? Score[FC]? FPR[FC]? Domaincoverage? Total FPR? Hits'classification?
PF05201.10_GlutR_N_seed? 1GPJ|A 222 7,142 1 0.00 1 0.00 1 0 TP,TP
Domain(s) to sequence segment[305,403]
Domain name? PDB? Length? Seq range? Score[FC/R]? FPR[FC/R]? Score[FC]? FPR[FC]? Domaincoverage? Total FPR? Hits'classification?
PF00745.15_GlutR_dimer_seed? 1GPJ|A 132 305,403 0.97 0.00 0.975 0.00 1 0 TP,TP
Alignments
PF00106.20_adh_short_seed:
E:1.10e-02[Original] E:3.62e-07[Fold-critical] E:2.07e-02[Remnant] Ratio[FC/R]:1.75e-05 Classification:TP
STRUCT SEEEEET?SSHHHHHHHHHHHHT-T?SEEEEEESS-------------GGGSTTHHHH-----HHHHH---HTT--?EEEEEE-??---TT?H-HHHHHHHHT??---TTS?EEEEEE????---??-S???TTT?-----?HHHHH--HHHHTT----HHHHHHHHHHHTT----S?------?SEEEEEEEHHHHTT?TT?HHHHHHHHHHHHHHHHHHHTT? PDB/DSSP
MODEL GTVLITGGTGGLGLAVARWLVAEHGARHLVLVSRRGLPDRSKWARRSLGPDAPGAAELEEKRRVAELEALEALGPEAEVTVAAQCDACVVADRLDALAALLAAIPKAAAEGPLTGVVHAAGVAFKLDGGDGVLESLESLTSTPERLDDGRVLAPKVNGVVDGAWHLHELTRDLMIKLDKGKDGELDAFVLFSSAAGVLGSPGQANYAAANAFLDALAEHRRAEGL HMMER2[PF00106.20_adh_short_seed]
QUERY KTVLVVG-AGEMGKTVAKSLVDR-GVRAVLVANRT--YERAVELARDLGGEAVRFDEL-----VDHLA--RSDV-VVSATAAP-HP---VIHV-DDVREALRKRD---RRSPILIID----I---AN--PRDVEEG------VENIE-----DVE----VRTIDDLRVIARE---NLE----------------------------------------RRRKEIP Q9UXR8|Glutamyl-tRNA_reductase|HEM1_METKA[168 305]
E:5.53e-05[Original] E:3.41e-11[Fold-critical] E:1.42e+04[Remnant] Ratio[FC/R]:2.40e-15 Classification:TP
STRUCT SEEEEET?SSHHHHHHHHHHHHT-T?SEEEEEESS-------------GGGSTTHHHH-----HHHHH---HTT--?EEEEEE-??---TT?H-HHHHHHHHT??---TTS?EEEEEE????---??-S???TTT?-----?HHHHH--HHHHTT----HHHHHHHHHHHTT----S?------?SEEEEEEEHHHHTT?TT?HHHHHHHHHHHHHHHHHHHTT? PDB/DSSP
MODEL GTVLITGGLGGLGLALARWLVEEHGARHLVLVSRRALPERSKWAEKSLGEDAPGAAELEEKLAIAELExxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx HMMER3[PF00106.20_adh_short_seed]
QUERY KTVLVVG-AGEMGKTVAKSLVDR-GVRAVLVANRT--YERAVELARDLGGEAVRFDEL-----VDHLAxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx Q9UXR8|Glutamyl-tRNA_reductase|HEM1_METKA[168 226]
PF01488.15_Shikimate_DH_seed:
E:1.90e-67[Original] E:5.07e-22[Fold-critical] E:6.54e-10[Remnant] Ratio[FC/R]:7.75e-13 Classification:TP
STRUCT HHHHHHHS---??T-T?EEEEES??HHHHHHHHHHHHH-??SEEEEE?SSHHHHHHHHHHH-----T?E---E??GGGHH---HHHHT?SEEE-E??SSSS?------------?B?HHHHHHHH---HH?SS???E-EEEE??SS?SB?TTGGGSTTEEEEEHHHHHHH PDB/DSSP
MODEL ELAKKIFGKSEDLKEGKKVLLIGAGEMAELVAKHLLAKLGAKKITIANRTYERAKELAEEFKERRNGGVEIEALPLDELESIEELLAEADIVIASATSAPEPPEEDIRARELVPIITKEMVERALKAFKKRKRRKPLRLFVDIAVPRDIEPEVGELEGVYVYTVDDLKEV HMMER2[PF01488.15_Shikimate_DH_seed]
QUERY ELAERELG---SLH-DKTVLVVGAGEMGKTVAKSLVDR-GVRAVLVANRTYERAVELARDL-----GGE---AVRFDELV---DHLARSDVVV-SATAAPHP------------VIHVDDVREAL---RKRDRRSPI-LIIDIANPRDVEEGVENIEDVEVRTIDDLRVI Q9UXR8|Glutamyl-tRNA_reductase|HEM1_METKA[156 292]
E:3.21e-40[Original] E:7.49e-37[Fold-critical] E:1.25e-06[Remnant] Ratio[FC/R]:5.99e-31 Classification:TP
STRUCT HHHHHHHS---??T-T?EEEEES??HHHHHHHHHHHHH-??SEEEEE?SSHHHHHHHHHHH-----T?E---E??GGGHH---HHHHT?SEEE-E??SSSS?------------?B?HHHHHHHH---HH?SS???E-EEEE??SS?SB?TTGGGSTTEEEEEHHHHHHH PDB/DSSP
MODEL ELAKKKFEKSESLKEGKKVLVIGAGEMARLAAKHLLSKLGVKKIVIANRTAEKAKELAEELKERRNGGEEVEALPLEELEAIAELLAEADVVIASATSAPTPTEEEIRARELVRIIEKEAVEEAKKASKKRKAEKPLGLLVDIAVPRDIEPEVAELEDVRVYNVDDLKEx HMMER3[PF01488.15_Shikimate_DH_seed]
QUERY ELAERELG---SLH-DKTVLVVGAGEMGKTVAKSLVDR-GVRAVLVANRTYERAVELARDL-----GGE---AVRFDELV---DHLARSDVVV-SATAAPHP------------VIHVDDVREAL---RKRDRRSPI-LIIDIANPRDVEEGVENIEDVEVRTIDDLRVx Q9UXR8|Glutamyl-tRNA_reductase|HEM1_METKA[156 291]
PF02826.14_2-Hacid_dh_C_seed:
E:8.79e-03[Original] E:7.17e-08[Fold-critical] E:3.51e-04[Remnant] Ratio[FC/R]:2.04e-04 Classification:TP
STRUCT HHHHHHHHTTH---HHHHHHH----TTT----??--------?TT---T??B?----??TT?EEEEE??SHHHHHHHHHHH-HTT?-EEEEE?SS----??----HHH---HHHTT?-EE?-?HHHH---HHH?SEEEE???-?STTTTT?B?HHHHHHS?TT?-----EEEE?S?GGGB?HHHHHHHHHHTSSSEEEES??SSS-----------S??----TT--------?---GG----GG--?TT-----EEE?SS?T PDB/DSSP
MODEL LALLLALARRIINGPEADRQVKRWKRAGRRDDKWESSGLGAWRPGCYFALLGRAGLRELSGKTVGIIGLGRIGRAVARRAKHAFGMKKVIAYDRYWSSDPKKKKEPEEAEEAEALGATRYVDSLDEL---LAESDVVSLHLPYLTPETRHLINAERLAKMKPGAPLGEPILINTARGGLVDEDALIDALKSGRIAGAALDVFEPESGYFFKDRKTKPLPAEVVADAKAFQKKLHTLKPLLKLLLESSLPNTIADKVILTPHIA HMMER2[PF02826.14_2-Hacid_dh_C_seed]
QUERY FRRAINLGKRA---REETRIS-----EG----AVSIG-SAAVELA---ERELG----SLHDKTVLVVGAGEMGKTVAKSLV-DRGVRAVLVANRT----YE----RAV-ELARDLGG-EAV-RFDELVDHLARSDVVVSATA------------------APH--------------PVIHVDDVREALRK-RDR----------------------------RS------------PILIIDIA--NPR------------- Q9UXR8|Glutamyl-tRNA_reductase|HEM1_METKA[127 269]
E:5.29e-09[Original] E:3.25e-10[Fold-critical] E:5.77e+00[Remnant] Ratio[FC/R]:5.63e-11 Classification:TP
STRUCT HHHHHHHHTTH---HHHHHHH----TTT----??--------?TT---T??B?----??TT?EEEEE??SHHHHHHHHHHH-HTT?-EEEEE?SS----??----HHH---HHHTT?-EE?-?HHHHHHH?SEEEE???-?STTTTT?B?HHHHHHS?TT?-----EEEE?S?GGGB?HHHHHHHHHHTSSSEEEES??SSS-----------S??----TT--------?---GG----GG--?TT-----EEE?SS?T PDB/DSSP
MODEL xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxALLGKAGLEELSGKTVGIIGLGRIGQAVAKRLKKAFGMKKVLAYDRSWSSDPKKKKEPEEAEEEEELGAERYVKSLDELLAESDIVSLHLxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx HMMER3[PF02826.14_2-Hacid_dh_C_seed]
QUERY xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxELAER-ELGSLHDKTVLVVGAGEMGKTVAKSLV-DRGVRAVLVANRT----YE--RAVELARDLGGEAV-RFD-ELVDHLARSDVVVSATxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx Q9UXR8|Glutamyl-tRNA_reductase|HEM1_METKA[156 235]
PF02882.14_THF_DHG_CYH_C_seed:
E:5.34e-01[Original] E:1.45e-09[Fold-critical] E:7.73e-06[Remnant] Ratio[FC/R]:1.88e-04 Classification:FN
STRUCT SHHHHHHHHTT--??----SS??HHHHHHHHHHHH-TT??---?TT?EEEEE???TTTHHHHHHHHHT---------T--------T?EEEEE?S-----------------S?---S?HHHHHHH?SEEEE?S??TT?B?TTTS---?TT?EEEE???EE?----------TTS?-EE?SB?HHHHHHH-?SEE??SSSSSHHHHHHHHHHHHHHHHHHTT PDB/DSSP
MODEL HPLNVGRLALGDGEPGDIDGFVPCTPAGIMELLKRAYGIDANFLAGKNAVVIGRSNIVGKPLALLLLNKGSTCGPAQAGPYDTKGGNATVTVCHS-----------------KTPPQKDLAEITRQADILVVAVGKPNLVKADWVANTKPGAVVIDVGINRVPDEDPEASKKGGGKILVGDVDFEEVKEKPASAITPVPGGVGPMTVAMLLKNTLEAAKRQL HMMER2[PF02882.14_THF_DHG_CYH_C_seed]
QUERY TRISEGAVSIG--SA-------------AVELAER-ELGS---LHDKTVLVVGAGE-MGKTVAKSLVD---------R------GVRA-VLVANRTYERAVELARDLGGEAVRF---DELVDHLARSDVVVSATAAPHP-----V-------------IHVD------------------DVR-EALRKR----------------------------DRRS Q9UXR8|Glutamyl-tRNA_reductase|HEM1_METKA[141 258]
E:8.87e-03[Original] E:2.45e-09[Fold-critical] E:1.48e+04[Remnant] Ratio[FC/R]:1.66e-13 Classification:FN
STRUCT SHHHHHHHHTT--??----SS??HHHHHHHHHHHH-TT??---?TT?EEEEE???TTTHHHHHHHHHT---------T--------T?EEEEE?SS?------S?HHHHHHH?SEEEE?S??TT?B?TTTS---?TT?EEEE???EE?----------TTS?-EE?SB?HHHHHHH-?SEE??SSSSSHHHHHHHHHHHHHHHHHHTT PDB/DSSP
MODEL xxVNLGRLVLGEEEEGDLDALLPCTPKGIVELLKRAYGIEANLLEGKKVVVVGRSNIVGKPLALLLLNKDSTAGPAKAAKKATAAVNATVTICHSKT---PPKKDLAEITREADIVVVAVGKPELVxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx HMMER3[PF02882.14_THF_DHG_CYH_C_seed]
QUERY xxINLGKRARE--ET-RISEGAVSIGSAAVELAER-ELGS---LHDKTVLVVGAGE-MGKTVAKSLVDRGVRAVLVA-----NRTYERAVELARDLGGEAVRFDELVDHLARSDVVVSATAAPHPVxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx Q9UXR8|Glutamyl-tRNA_reductase|HEM1_METKA[131 241]
PF03446.10_NAD_binding_2_seed:
E:3.00e-01[Original] E:4.04e-07[Fold-critical] E:6.43e-03[Remnant] Ratio[FC/R]:6.28e-05 Classification:FN
STRUCT ?BSEEEE??SHHHHHHHHHH---H-HTT??-EEEE?-SS--H-----HHHHHHH-H---HHT-----TSSEEE?SSHH-HHHHTB?---SS?EEEE?S?TTHHHHHHHHH--------HT--TT?--------?TT--?-----EEEE?S???HHHHHHHHHH-HHHHT--?EEEEEEEESHHHHHHH??-EEEEE---E?HH-HHHHHHH-HHHHHS?EET---TEESB?-------??BS PDB/DSSP
MODEL MAKIGFIGLGVMGSPMALNLYNKAGKAGYT-VTVYNIRTLEPPGVEEEKTEELVAEFAGGAKEKPAGGKNAVGAASPAVEFVASLEGEPKPDVVITMVPAGAAVDAVILGPEDGSGGGLLEGPGLKKCATDISEPGHRD-----IIIDGSTSDPEDTRRRAKELLAEKGPDIHFLDAPVSGGEEGARNGTLSIMVGR-EGDEEKAFERVKPYILEAIGAKVDKNDGEPCVTAPDRGGHYIGP HMMER2[PF03446.10_NAD_binding_2_seed]
QUERY DKTVLVVGAGEMGKTVAKSL---V-DRGVRAVLVAN-RT--Y-----ERAVELARD--LGGE--------AVRFDELV-DHLARS------DVVVSATAAPHPVIHVDD---------VR--EAL--------RKR--DRRSPILIIDIAN--PRDVEEGVEN-IEDVE--VRTID------DLRVIARE------NLERRRK-EIPKVEK-LIEEELS---------TVE-------E--E Q9UXR8|Glutamyl-tRNA_reductase|HEM1_METKA[167 321]
E:1.27e-03[Original] E:3.07e-09[Fold-critical] E:1.48e+04[Remnant] Ratio[FC/R]:2.07e-13 Classification:FN
STRUCT ?BSEEEE??SHHHHHHHHHH---H-HTT?-?EEEE?-SS--H-----HHHHHHH-H---HHT-----TSSEEE?SSHH-HHHHTB?---SS?EEEE?S?TTHHHHHHHHH--------HT--TT?--------?TT--?EEEE?S???HHHHHHHHHH-HHHHT--?EEEEEEEESHHHHHHH??-EEEEE--E?HH-HHHHHHH-HHHHHS?EET---TEESB?-------??BS PDB/DSSP
MODEL xxKIGFIGLGVMGSPMALNLYNKLGKAGY-EVAVYNLRTLEPPGVEEEKVEELVAEFAAGAKASPANKKKAKAAESIELEFVASLESEPKPDVVITMVPAGAAVDEVxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx HMMER3[PF03446.10_NAD_binding_2_seed]
QUERY xxTVLVVGAGEMGKTVAKSL---V-DRGVRAVLVAN-RT--Y-----ERAVELARD--LGG--------EAVRFDELV-DHLARS------DVVVSATAAPHPVIHVxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx Q9UXR8|Glutamyl-tRNA_reductase|HEM1_METKA[169 244]
PF03807.12_F420_oxidored_seed:
E:8.73e-06[Original] E:2.58e-07[Fold-critical] E:5.19e-03[Remnant] Ratio[FC/R]:4.97e-05 Classification:TP
STRUCT EEEEETTTSHHHHHHHHHHHHTT-------?EEEEE-ESSHHHHHHHH-HHHHHH-------H?S??EEEEEHHHHHH---H?SEEEE?-------S?GGGHHHHHHHT-------HHHHTTSEEEE???? PDB/DSSP
MODEL KIGIIGGAGNMGEALARGLAAAGVTPSLPPHEVIIANSRNPEKAAALALEEYGEILAECGDEGSDVKATAVSNEEAAE-LIEADVVFLA-------VPPQAVPEVLSELGNATAAAADLLKGKLVISITNG HMMER2[PF03807.12_F420_oxidored_seed]
QUERY TVLVV-GAGEMGKTVAKSLVDRGV------RAVLVA-NRTYERAVELA-RDLG--------------GEAVRFDELVDHLARSDVVVSATAAPHPVIHVDDVREALRKR--------DRRSPILIIDIANP Q9UXR8|Glutamyl-tRNA_reductase|HEM1_METKA[169 268]
E:2.93e-07[Original] E:3.28e-11[Fold-critical] E:1.14e+03[Remnant] Ratio[FC/R]:2.88e-14 Classification:TP
STRUCT EEEEETTTSHHHHHHHHHHHHTT-------?EEEEE-ESSHHHHHHHH-HHHHHH-------H?S??EEEEEHHHHHH--H?SEEEE?S----?GGGHHHHHHHT-------HHHHTTSEEEE???? PDB/DSSP
MODEL xxxIIGGTGNIGEALARGLAAAGATPELPKHEVIIANSRSPEKAEELALEELGEILENCGDEKSDVKVTGVSNEEAAELIEADVVILAV----KPEDVEEVLSELANATAAAKEALKGKLVISILAG HMMER3[PF03807.12_F420_oxidored_seed]
QUERY xxxVV-GAGEMGKTVAKSLVDRGV------RAVLVA-NRTYERAVELA-RDLG---------GEAVR--FDELVDHLA--RSDVVVSATAAPHPVIHVDDVREAL-----RKRDRRSPILIIDIANP Q9UXR8|Glutamyl-tRNA_reductase|HEM1_METKA[172 268]
PF08659.5_KR_seed:
E:4.86e+00[Original] E:1.10e-04[Fold-critical] E:4.77e-05[Remnant] Ratio[FC/R]:2.31e+00 Classification:FN
STRUCT SEEEEETTTSH---HHHHHHHHHH-H----TT-?SEEEEEESS-G-------------GGSTTHH-----H------------HH----HHHHH-T-T?----EEEEEE??--TT?HHHHHHH---HHTS?SSS----?EEEEEE??????S??-?TTT??HHHHHHHHHTTHHHHHHHHHHHTT-------S??SEEEEEEEGGG-TT??T--T?HHHHHHHHHHHHHHHHHHHTT??------?EEEEE??BSSS PDB/DSSP
MODEL GTYLVTGGLGGTGTLGLELARWLANEGIGGRGPARHLVLLSRSPGLPPRRAWEWLEASAPDPEAALASRAAESERRETRARIRLLHPAFAELEADRYGALDIGEVTVVACDEMVADRDAVRALFDLLAEIRADGEELPPLRGVIHAAGVLRRDAILLANMTAEDFARVLAPKVTGAWNLHEATRDADPLLLGRPLDFFVLFSSIAGKVLGSAKFGQANYAAANAFLDALAHYRRAQGLPGRRRGRALSINWGPWADG HMMER2[PF08659.5_KR_seed]
QUERY -TVLVVG-AGE---MGKTVAKSLV-D----RG-VRAVLVANRT-------------------YER------------------AV----ELARD-L-GG----EAVRFD--ELVDHLARSDVV---VSATAAPHP-------VIHVDDVRE----ALRKRDRRSPI---------------LIID------------------IAN-----P------------------RDVEEGVEN--------------IEDV Q9UXR8|Glutamyl-tRNA_reductase|HEM1_METKA[169 281]
E:6.51e-03[Original] E:1.70e-11[Fold-critical] E:1.48e+04[Remnant] Ratio[FC/R]:1.15e-15 Classification:FN
STRUCT SEEEEETTTSH---HHHHHHHHHH-H----TT-?SEEEEEESS-G-------------GGSTTHH-----H------------HH----HHHHH-T-T?----EEEEEE??--TT?HHHHHHH---HHTS?SSS----?EEEEEE??????S??-?TTT??HHHHHHHHHTTHHHHHHHHHHHTT-------S??SEEEEEEEGGG-TT??T--T?HHHHHHHHHHHHHHHHHHHTT??------?EEEEE??BSSS PDB/DSSP
MODEL xTYLVTGGLGGTGTLGLELARWLAEEGIGGRGEARHLVLLSRSAALPEEEAEKLLEESAPDAEAELASEAAESEAAETKARIALLHPAFAELEADLAGALDIIEVTVVAADELVADRDAVRALLDLLEEVEAEGxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx HMMER3[PF08659.5_KR_seed]
QUERY xTVLVVG-AGE---MGKTVAKSLV-D----RG-VRAVLVANRT-Y---ER--AVELARDLGGEAV--------------RFDELV----DHLAR-S-DV--VVSATAAPHP--VIHVDDVREA---LRKRDRRSxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx Q9UXR8|Glutamyl-tRNA_reductase|HEM1_METKA[169 258]
PF13241.1_NAD_binding_7_seed:
E:9.13e-02[Original] E:1.07e-04[Fold-critical] E:9.26e-02[Remnant] Ratio[FC/R]:1.16e-03 Classification:TP
STRUCT EEE-??TT--?EEEEEEESHHHH--HHHHHHGG-GT--?-E-E--EE--------E-E---EE---------E?TTHHHHH?G-------------------------------GG????-??-------------??-----????--------?---------EE-------------------------------------------------E-----------?TT??TTS???SEEE?----------SS??GGGG??SST-T-----?----------?EE---------EEE---E??----S?--HHHHHH--HHH----HH--HHHH?TTS--EEE-ETT--------?G---GGBS-----------EE??E PDB/DSSP
MODEL LFLTDLEGIEKRVLVVGGGEVALCKRKIRSLLEGAGPDAGKEVQLTVAWNAPVAVVFSDIIPEITPNDAAKELLTPELEELAALDADFDGASDKAILKNQRAGNGKVTKYDNKLLAEAGLPIRKGQQARFFEADNVELPDQPCVRFAPRLGIELLRLGAISVRSARENIVLENKIDTGANIENTELENTLDKRYSSNSNLKNISDDLEIITILRRNFITLIKDQRAYREPGDLLTLEEILKDKIDALSGVFDNIEEDKEEELQLNELEDPNESFGNDKSLSLACVADPSRVMNIINALVIKDNAAT----DDRTPELNERTIIAAILAKLAAERAKFGRGIYLLVNDVADVSAADRSGDPGGRELCDKENRALSTALEFIFPA HMMER2[PF13241.1_NAD_binding_7_seed]
QUERY LG--SLHD--KTVLVVGAGEMGK--TVAKSLVD-RG--V-R-A--VL--------V-A---NR-------------TYE---------------------------------------RA-VE--------------L--------A-------RDLGGEAVRFDEL-------------------------------------------------V-------------DH----------------------------------L-A-----R----------SD----------VVV---SATAAPHPV--IHVDDV--REA----LR-KRD---RRS--PIL-IID--------IA---NPRD-----------VEEGV Q9UXR8|Glutamyl-tRNA_reductase|HEM1_METKA[162 275]
E:7.38e-03[Original] E:8.65e-08[Fold-critical] E:3.39e+02[Remnant] Ratio[FC/R]:2.55e-10 Classification:FN
STRUCT EEE-??TT--?EEEEEEESHHHH--HHHHHHGG-GT--?-E-E--EE--------E-E---EE---------E?TTHHHHH?G-------------------------------GG????-??-------------??-----????--------?---------EE-------------------------------------------------E-----------?TT??TTS???SEEE?----------SS??GGGG??SST-T-----?----------?EE---------EEE---E??S?--HHHHHH--HHH----HH--HHHH?TTS--EEE-ETT--------?G---GGBS-----------EE??E PDB/DSSP
MODEL xxxxxLKGIEKRVLVVGGGEVAACKRKVRKLLEGAGPEAGKEVQLTVAWNAPVANVFSDIIPExxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx HMMER3[PF13241.1_NAD_binding_7_seed]
QUERY xxxxxLHD--KTVLVVGAGEMGK--TVAKSLVD-RG--V-R-A--VL--------V-A---NRxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx Q9UXR8|Glutamyl-tRNA_reductase|HEM1_METKA[165 199]
PF13460.1_NAD_binding_10_seed:
E:2.40e-02[Original] E:2.69e-06[Fold-critical] E:8.56e-01[Remnant] Ratio[FC/R]:3.14e-06 Classification:TP
STRUCT EEEESTTSHHHHHHHHHHHHTT----?EEEEEE---S?-??----???---------?SSEEEE??T--T?H---HHHHHHHT---T--?SEEEE??------?TT---T??GG--------G-------HHH--H--HH----HHHHHHH-H---H-T--??-E--EE---E--E-??GG---G?E-----EETT-----EEG--GGSTT?------?GGGHHH-H----HHH--H-HH-----H-----HHH----T--T??--SS-EEEEEE??S-EEES-------?---??--????EE-----ESS--------B????-----T-T-----S?-----?EEEHHHHHHHHHHHHHH PDB/DSSP
MODEL IAVIGATGKTGRRIVKEALARGKFKVHEVTALVLHGRNAPSVVPSKLPELNEASLFGPGVTPVQKDLALFDLSIVEDLAEALAMLPGKPFDAVVDAFRPLKAAGARSWEPPIDLTDSGPAKVDTLAVLPLFRDSLGGSVKTSLSHLLDALASGLIDARGESVRMR-PLVWAGVGGVLSSAGSLRLYRQSGHVDVPGLELVFFGLNIDDTPLFPELKRIREAIKPYSARPLARAKILALAAYGDSLEKEALKELLEQLLRAAAVSAKGLEDWTIVRPAADLFDALSESAATEGPGGGTETGTYELKTRSWGTEDEGNMVSILLIGDVLRLYPSATLNSRGEKEAGESPISRADVAAALVDELEN HMMER2[PF13460.1_NAD_binding_10_seed]
QUERY VLVVGA-GEMGKTVAKSLVDRG----VRAVLVA--NRT-YE----RAVEL--ARD--LGGEAVRF----DEL-----VDH-LA---R--SDVVVSAT------AAP---HP--------------------VI--H--VD----DVREALR-K---R-D---R-RSPIL---I--I-DIAN---PRD-----VEEG-----VEN-------------IEDVEVRT-I----DDL--RVIA----RE-----NLE----R--R-R-KEI---------P-KVEKL------I---EE----ELST-----VEE-----------EL-----E-K-----LK-----ERRLVADVAKSLHEIKDR Q9UXR8|Glutamyl-tRNA_reductase|HEM1_METKA[170 344]
PF01408.17_GFO_IDH_MocA_seed:
E:8.97e-02[Original] E:3.09e-04[Fold-critical] E:4.18e-02[Remnant] Ratio[FC/R]:7.39e-03 Classification:TP
STRUCT EEEEEE??-SHH---HHHT---HHHHGGG?SSE-------EEEEEE?S?HHHHHHH----HHHHT??GGGEE?SSS----------GG-GGGG?T--T---??EEEE?S?T------TH----HHHHHHHHHHTT?--EEEE?SSS?S------SHHHHHHHHHHHHHHT----------??-EEE?? PDB/DSSP
MODEL LRVGIVGAAGRINLFGRRHCDRLRALLESQDGAKKLGPRLELVAVLDPDPARAEAVLKEKAESFGVPARKEKVYSDTKVYPSVEEYLEYELLADPAKDDDGIDAVIVATPNAVHGRGGLTPSPHFELALAALEAGKNAHVLCEKPLATGVPAEGTLEEAKELVELARKKGCKDEKRGKDAVVVLQVGF HMMER2[PF01408.17_GFO_IDH_MocA_seed]
QUERY KTVLVVGA-GEM---GKTV---AKSLVDR--GV-------RAVLVANRTYERAVEL----ARDLGGE---AVRFDE----------LV-DHLA----R---SDVVVSATAA------PH-------------------PVI-------------HVDDVREALRKRDRRS----------PI-LIIDI Q9UXR8|Glutamyl-tRNA_reductase|HEM1_METKA[168 265]
PF02254.13_TrkA_N_seed:
E:3.55e-02[Original] E:1.01e-03[Fold-critical] E:1.15e-02[Remnant] Ratio[FC/R]:8.78e-02 Classification:TP
STRUCT EEEE?-?SHHHHHHHHHHHHTT-?------------------EEEEEES?H--HH--HHHH--H-HH?--SSE--------EEE-S?TTSHHHHHHT-TTTT?S--EEEE?---?S-------?H----HHHHHH--HHHH-HH---TT???---EE--EE?SSTTH-----HHHH-HH--TT-----?--SEEE?H PDB/DSSP
MODEL IIIIGAYGRVGRSLAEELSEEGHGVEKSFLSKLLPIDLEQIPDVVVIDKDEIDERKGVEELLEREEEGPDDTLVPGEAGAYVVVRGDATDEEVLEEALGIEDADCKAVIAASLPTGIEKNELDDDLLKIEANILI--VLLAKKELNPDGVKKPFYIILPARANDPEHLKPESAEKLKRRENLGRLIFMASIDEVISP HMMER2[PF02254.13_TrkA_N_seed]
QUERY VLVVG-AGEMGKTVAKSLVD-R-G----------------VR-AVLVANRTYERA--VELA--R-DLG-----------------GEAVRFDELVDH--LARSD--VVVSA---TA-------AP----HPVIHVDDVREA-LRKRDRRSPI---LI--IDIANPRDV----EEGV-EN--IE--------DVEVRT Q9UXR8|Glutamyl-tRNA_reductase|HEM1_METKA[170 285]
PF03949.10_Malic_M_seed:
E:3.44e-02[Original] E:1.75e-05[Fold-critical] E:1.38e-08[Remnant] Ratio[FC/R]:1.27e+03 Classification:TP
TM ----------------------------------------ccc--ccccccc---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- TMSOC
STRUCT THHHHHHHHHHHHHHHHHHTS?---G------GG??EEEE??S--HHHHHHHHHHHHHHHHH-T??H---HHHHTTEEEEETTEE?BTT?-SS--?------?-----TTGGG----G?BS?????--------------?HHHHHHHH??SEEEE?S?-?TT-?S?HHHHHHHHHH?S------S?E-EEE??SSGGG?SS?HHHHHHHTTT??EEEESS????EE?TTS?EE??EE??GGGTHH--HHHHHHHHHT?SS??HHHHHHHHHHHHHT??HH--------------HHHH-T?SS??GGGHHHHHHHHHHHHHHHHH PDB/DSSP
MODEL IQGTAAVVLAGLLNALKITGKPLIDLNRTAKASDQKIVFFGAGRCAAGIGIAELLVAAMVRETGLSESAFEEARKNIWMVDRKGLLTEDRKEDGKLDRLMLLNNGTMPPFKKPGLRYFARKTNEVKGWGRDDKHDDGDGGTLAEVVKGAKPDVLIGVSGPVPG-AFTEEIVRAMAEHTEAGGLGTRPI-IFALSNPTPKAEITPEDAYKWTAGRVLFATGSPFPPVELPNGRSDYPNQVNNVLIFPVSGIGLGALDVRARRITDEMFLAAAEALAELVTEEVPDVVASAYGGEKLELGEYGYIIPPLFDIREVSPRVAVAVAKAAV HMMER2[PF03949.10_Malic_M_seed]
QUERY ----GAVSIGS--AAVELAERELGSL------HDKTVLVVGAG--EMGKTVAKSLVDR-----GVR----A-------------VLVANR--T---------Y-----ERAVE----LARDLGGEAVR-FD---------ELVDHLARS--DVVVSATA-APHPVIHVDDVREALRKRD----RRSPILIIDIANPRD---------VEEGVENI--------EDVEV-------------------------------RTIDDL------RVIARENLER--------------RRKE----IPKVEKLI---EEELSTVEEELE Q9UXR8|Glutamyl-tRNA_reductase|HEM1_METKA[146 323]
PF07991.7_IlvN_seed:
E:1.65e-04[Original] E:1.84e-09[Fold-critical] E:4.47e+02[Remnant] Ratio[FC/R]:4.12e-12 Classification:TP
STRUCT HHHT-S?EEEE??SHHHHHHHHHHHHTT?-?EEEE??TT?----H-HHHHHHHTT?EEE?HHHHHH---T?SEEEE?S?HHHHHHHHHHHTGGG??TT?--EEEES??HHHHTTSS???TT?EEEEEEESS?SHHHHHHHHTT????EEEEEE--E?SS-S?HHHHHHHHHHHTTHHHH? PDB/DSSP
MODEL xLKGAKKIAVIGYGSQGHAQALNLRDSGLKDVVVGLREGSILEKKKSVEKAKKDGFEVLTVAEAVK---KADVVMIxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx HMMER3[PF07991.7_IlvN_seed]
QUERY xLHD-KTVLVVGAGEMGKTVAKSLVDRGVRAVLVANRTYE----R-AVELARDLGGEAVRFDELVDHLARSDVVVSxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx Q9UXR8|Glutamyl-tRNA_reductase|HEM1_METKA[165 233]
PF05201.10_GlutR_N_seed:
E:1.85e-56[Original] E:9.89e-26[Fold-critical] E:7.73e-07[Remnant] Ratio[FC/R]:1.28e-19 Classification:TP
STRUCT EEEETTTS?HHHHHHHS???-TTHHH------HH-HHHHT?S----EEEEEEETTEEEEE----EES?TT-?H-------------------------------------------HHHHH-----TT---?T-T-----?EEEE---HHHHHHHHHHHHTTTT----SSSTT?HHHHHHHHHHHHHHH-----HHT???HHHHHHHHHHHHHHHHHHHHSS PDB/DSSP
MODEL VGLNHKTAPVEIREKLAFSPDEELEENQALQVELKKALPGVDYASREAVILSTCNRTEIYFSSEAYSSVDLDPLSAVSEAGLEKKNDLILIDESVSANNSANLSSTIIVDLILKLKEWLAEIFHGLLDGASLEPEVLEPYLYVYEVYEGEEAVRHLFRVASGLDLVWISMVLGEPQILGQVKEAYALARNFYQSEAGTVGKILNRLFQKAFSVAKRVRTETA HMMER2[PF05201.10_GlutR_N_seed]
QUERY VGITHKEAEVEELEKARFES-DEAVR------DI-VESFGLS----GCVLLQTCNRVEVY----ASGARD-RA-------------------------------------------EELGD-----LI---HD-D-----AWVKR---GSEAVRHLFRVACGLE----SMMVGEQEILRQVKKAYDRAA-----RLGTLDEALKIVFRRAINLGKRAREETR Q9UXR8|Glutamyl-tRNA_reductase|HEM1_METKA[7 142]
E:4.90e-39[Original] E:3.47e-48[Fold-critical] E:1.48e+04[Remnant] Ratio[FC/R]:2.34e-52 Classification:TP
STRUCT EEEETTTS?HHHHHHHS???-TTHHH------HH-HHHHT?S----EEEEEEETTEEEEE----EES?TT-?H-------------------------------------------HHHHH-----TT---?T-T-----?EEEE---HHHHHHHHHHHHTTTT----SSSTT?HHHHHHHHHHHHHHH-----HHT???HHHHHHHHHHHHHHHHHHHHSS PDB/DSSP
MODEL IGVNHKTAPVELREKLAFSEEEELEESLALAEQLKKSEEGIEKASAEAVILSTCNRTEIYALVEASSSSESDALLENSEAAVEKKSELSVIESSVTANNSANLSSTIISAHILKIKEWLAEIFKQLLSEESLELEELEEYLYVLELYEGEEAVRHLFRVASGLDLVWISMVLGEPQILGQVKRAYELAKNFYQSEAGTLGKILNRLFQKAFAVAKRVRTETA HMMER3[PF05201.10_GlutR_N_seed]
QUERY VGITHKEAEVEELEKARFESDEAVRD--IVE------SFGLS----GCVLLQTCNRVEVY----ASGARD-----------RA---------------------------------EELGD-------------L-IHDDAWVKR---GSEAVRHLFRVACGLE----SMMVGEQEILRQVKKAYDRAA-----RLGTLDEALKIVFRRAINLGKRAREETR Q9UXR8|Glutamyl-tRNA_reductase|HEM1_METKA[7 142]
PF00745.15_GlutR_dimer_seed:
E:1.57e-18[Original] E:3.51e-10[Fold-critical] E:3.56e-04[Remnant] Ratio[FC/R]:9.86e-07 Classification:TP
STRUCT HHHHHHHH---HHHHHHHHHHHHH-H----HHHHHHHHHHHHHHHHHHHHHHHHS?---S?----??-??-????TTHHHHHHHHHHHHHHHHHHS-S?-TTTT--THH-----HHHHHHHHH--H-----T PDB/DSSP
MODEL EKAEAIIESINEEVEEFMEWLRSLQEPVGGVVPTIRALREKAEEIREEELERALKKLGLLDKYGNLGEDPVEEVLEKLARSLTNKLLHAPTVALKECAARAEGDGFDDLTLVENLEALRRLFGSDLAQSNHD HMMER2[PF00745.15_GlutR_dimer_seed]
QUERY PKVEKLIE---EELSTVEEELEKL-K----ERRLVADVAKSLHEIKDRELERALRR---LK----TG-DP-ENVLQDFAEAYTKRLINVLTSAIME-LP-DEYR--RAA-----CRALRRASE--L-----N Q9UXR8|Glutamyl-tRNA_reductase|HEM1_METKA[305 403]
E:1.51e-14[Original] E:7.45e-19[Fold-critical] E:4.69e+02[Remnant] Ratio[FC/R]:1.59e-21 Classification:TP
STRUCT HHHHHHHH---HHHHHHHHHHHHH-H----HHHHHHHHHHHHHHHHHHHHHHHHS?---S?----??-??-????TTHHHHHHHHHHHHHHHHHHS-S?-TTTT--THH-----HHHHHHHHH--H-----T PDB/DSSP
MODEL xQAEAIIESINEEVEEFEEWLKSLQEPVGGVVPLIRALREKAEEIREEELEKALKKLGLLAKKAELGEDPVEEVLEKLARSLTNKLLHGPTKALREAAARADGDAADELTLVENLEALRRLFDSDLxxxxxx HMMER3[PF00745.15_GlutR_dimer_seed]
QUERY xKVEKLIE---EELSTVEEELEKL-K----ERRLVADVAKSLHEIKDRELERALRR---LK-----TGDP-ENVLQDFAEAYTKRLINVLTSAIME-LP-DEYR--RAA-----CRALRRASE--Lxxxxxx Q9UXR8|Glutamyl-tRNA_reductase|HEM1_METKA[306 402]
User sequence
Q9UXR8|Glutamyl-tRNA_reductase|HEM1_METKA
MEDLVCVGITHKEAEVEELEKARFESDEAVRDIVESFGLSGCVLLQTCNRVEVYASGARDRAEELGDLIHDDAWVKRGSEA
AVRHLFRVACGLESMMVGEQEILRQVKKAYDRAARLGTLDEALKIVFRRAINLGKRAREETRISEGAVSIGSAAVELAERE
ELGSLHDKTVLVVGAGEMGKTVAKSLVDRGVRAVLVANRTYERAVELARDLGGEAVRFDELVDHLARSDVVVSATAAPHPV
VIHVDDVREALRKRDRRSPILIIDIANPRDVEEGVENIEDVEVRTIDDLRVIARENLERRRKEIPKVEKLIEEELSTVEEE
ELEKLKERRLVADVAKSLHEIKDRELERALRRLKTGDPENVLQDFAEAYTKRLINVLTSAIMELPDEYRRAACRALRRASE
ELNG
Main reference
1) Wing-Cheong Wong, Sebastian Maurer-Stroh, Birgit Eisenhaber, Frank Eisenhaber, 2014,
The necessity of dissecting similarity scores for inferring homology: an essential issue in protein function prediction and annotation
, BMC Bioinformatics, 15(1):166, doi:10.1186/1471-2105-15-166
Relevant references
1) Wing-Cheong Wong, Sebastian Maurer-Stroh, Georg Schneider, Frank Eisenhaber, 2012,
Transmembrane helix: simple or complex
, Nucleic Acids Research (Web Server issue), doi:10.1093/nar/gks379
2) Wing-Cheong Wong, Sebastian Maurer-Stroh, Frank Eisenhaber, 2011,
Not all transmembrane helices are born equal: Towards the extension of the sequence homology concept to membrane proteins
, Biology Direct, 6(57), doi:10.1186/1745-6150-6-57
3) Wing-Cheong Wong, Sebastian Maurer-Stroh, Frank Eisenhaber, 2011,
The Janus-faced E-values of HMMER2: Extreme value distribution or logistic function
, Journal of Bioinformatics and Computational Biology, 9(1), doi:10.1142/S0219720011005264
4) Wing-Cheong Wong, Sebastian Maurer-Stroh, Frank Eisenhaber, 2010,
More than 1001 problems with protein domain databases: transmembrane regions, signalpeptides and the issue of sequence homology
, PLoS Computational Biology, 6(7), doi:10.1371/journal.pcbi.1000867
Contact
wongwc@bii.a-star.edu.sg
24-03-2015 17:51:43 Copyrights Bioinformatics Institute A*STAR