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["Upstream Regulator","Expr Fold Change","Molecule Type","Predicted Activation State","Activation z-score","p-value of overlap","Target Molecules in Dataset","Mechanistic Network"]
["OGA"," ","enzyme","Inhibited",-2.673,0.0347,"AZGP1,C1QB,Ccl9,CH25H,COLEC11,FGFR4,GABRA2,GP9,HK3,HPGD,IFIT3,ITGA2,TEKT5,Zfp459"," "]
["IRF3"," ","transcription regulator","Inhibited",-2.572,0.00579,"ABCC2,HLA-F,IFI16,IFIH1,IFIT3,LCN2,Ms4a4c (includes others),NOS2,Trim30a/Trim30d,ZBP1","80 (10)"]
["RELA"," ","transcription regulator","Inhibited",-2.388,0.32,"BCL2A1,EOMES,IGHM,IL22,IL7R,NOS2,SAA1,SELE,Serpina3g (includes others),SHBG"," "]
["IKBKE"," ","kinase","Inhibited",-2.236,0.0078,"HLA-A,IFI16,IFIH1,IFIT3,NOS2","96 (11)"]
["Tnf (family)"," ","group","Inhibited",-2.011,0.0256,"BCL2A1,DUOX1,LCN2,NOS2,SAA1,SELE,SHBG"," "]
["TNFRSF1A"," ","transmembrane receptor"," ",-1.996,0.197,"IL22,LCN2,NOS2,SAA1,SELE"," "]
["LEP"," ","growth factor"," ",-1.991,0.26,"APOA2,BCL2A1,CCNA2,CYP11A1,CYP24A1,CYP2E1,ITGAX,MMP12,NOS2,NPW,SELE"," "]
["NOS2",-1.132,"enzyme"," ",-1.977,0.00115,"AZGP1,BCL2A1,Ccl9,CYP2E1,H2-T10,IFIT3,LCN2,MYH6,MYL2,NOS2,Slfn2","102 (10)"]
["Pro-inflammatory Cytokine"," ","group"," ",-1.951,0.00198,"ABCC2,HP,LCN2,NOS2,SELE,SPINT1"," "]
["EIF2AK2"," ","kinase"," ",-1.926,0.121,"BCL2A1,NOS2,REC8,SELE"," "]
["EBF1"," ","transcription regulator"," ",-1.914,0.255,"Ccl9,IGHM,Ly6a (includes others),RAG1"," "]
["TLR3"," ","transmembrane receptor"," ",-1.882,4.68e-05,"AIM2,Apol11b (includes others),Apol7e (includes others),BFSP2,CCL17,GBP3,IFI16,Ifi202b,IFI44L,IFIH1,IFIT3,LCN2,NOS2,SELE,SLPI,Wfdc18","95 (13)"]
["NFKBIA"," ","transcription regulator"," ",-1.79,5.01e-05,"AZGP1,BCL2A1,BUB1B,CARD10,Ccl9,CCNA2,CH25H,EOMES,FGFR4,GBP3,Gm21596/Hmgb1,GZMK,HLA-A,HMGA1,IFI16,IL7R,ITGA2,LCN2,NOS2,SELE,SFRP1,Slfn2","109 (14)"]
["CTNNB1"," ","transcription regulator"," ",-1.78,0.197,"ABHD12B,CCNA2,COL4A6,CYP11A1,CYP24A1,CYP2E1,EOMES,IGHM,KIF23,MPZ,MYH6,NOS2,NPHS2,PAX1,SAA1,SFN,SFRP1,SP6,TDGF1"," "]
["Ifnar"," ","group"," ",-1.675,0.00228,"AIM2,HLA-A,HLA-E,IFI16,IFIH1,IFIT3,ZBP1","100 (13)"]
["TBX21"," ","transcription regulator"," ",-1.664,0.00213,"EOMES,IL21,IL22,IL7R,PDCD1,STAT4","87 (8)"]
["IRF7"," ","transcription regulator"," ",-1.606,2.88e-05,"GBP3,IFI16,IFI44L,IFIH1,IFIT3,ITGAX,LILRA5,Ly6a (includes others),MICB,Ms4a4c (includes others),Trim30a/Trim30d,TRIM5,ZBP1","76 (9)"]
["IL21",3.253,"cytokine"," ",-1.381,9.11e-06,"CCL17,EOMES,GBP6,HLA-DRB5,IFI16,IFIT3,IL21,IL7R,MMP12,NOS2,PDCD1,Serpina3g (includes others),SLFN13,STAT4","110 (13)"]
["HNF1A"," ","transcription regulator"," ",-1.358,0.0425,"ABCC2,Akr1c19,APOA2,CYP2E1,FGL1,FUT10,GLP1R,HAL,MSH5,NPC1L1,PCSK9,PLG,SLPI,SULT1C2,Ugt1a7c"," "]
["cytokine"," ","group"," ",-1.357,0.00978,"ANG,C5AR1,CCR6,Ly6a (includes others),MMP12,NOS2,SAA1,SELE"," "]
["SPI1"," ","transcription regulator"," ",-1.268,0.00201,"CCL17,CCNA2,CCR6,EPX,HK3,IFI44L,IFIT3,IL21,IL7R,LILRB3,NOS2,RAG1,SP6"," "]
["TCF4"," ","transcription regulator"," ",-1.242,0.000688,"AMHR2,ARHGAP4,CCNA2,DMP1,GIMAP4,GP9,IFI16,Ly6a (includes others),NOS2,Serpina3g (includes others),SLC66A3,ZBP1"," "]
["PLAU"," ","peptidase"," ",-1.217,0.00198,"ANG,C5AR1,MMP12,PLG,SLFN13,SLPI"," "]
["Ifn"," ","group"," ",-1.193,0.000568,"CH25H,HLA-A,IFI16,Ifi202b,IFIH1,LCN2,NOS2,TLR1,ZBP1","63 (8)"]
["GATA3"," ","transcription regulator"," ",-1.182,0.0325,"CYP11A1,EOMES,EVPL,IL22,IL7R,PDCD1,RAG1,SLPI,STAT4"," "]
["IFNAR1"," ","transmembrane receptor"," ",-1.179,3.31e-05,"Apol11b (includes others),Apol7e (includes others),CCL17,Ccl9,CH25H,HLA-A,IFI16,IFIH1,IFIT3,Ly6a (includes others),Ms4a4c (includes others),NOS2","94 (11)"]
["RARA"," ","ligand-dependent nuclear receptor"," ",-1.129,0.0466,"1700097N02Rik,ABCC2,CCNA2,CD84,FGFR4,H4C3,HOXA1,IFI44L,IL21,IL22,KIF23,PTTG1"," "]
["YY1"," ","transcription regulator"," ",-1.109,0.0449,"BUB1B,CCNA2,CD22,CYP24A1,H4C3,HLA-DRA,KIF23,let-7,MYH6,TNNI1"," "]
["IL7"," ","cytokine"," ",-1.108,0.024,"IGHM,IL21,IL22,IL7R,Ly6a (includes others),PDCD1,RAG1"," "]
["IL22",-5.009,"cytokine"," ",-1.104,0.00988,"CCL17,CYP2E1,HP,IL22,LCN2,NOS2,SAA1","38 (3)"]
["CEBPA"," ","transcription regulator"," ",-1.067,0.0147,"APLNR,BCL2A1,Ccl9,CCNA2,CYP11A1,EVPL,GP9,HMGA1,HP,HPGD,ITGAX,LCN2,LEFTY1,Ly6a (includes others),RAG1,SAA1"," "]
["CHUK"," ","kinase"," ",-1.024,0.00831,"Ccl9,CH25H,GBP3,HLA-A,IFI16,IL22,LCN2,SELE,SFRP1,Slfn2","91 (10)"]
["IFNA2"," ","cytokine"," ",-1.023,0.018,"HLA-A,HLA-E,IFI16,IFI44L,IFIH1,IFIT3,PTTG1,REC8,STAT4,ZBP1"," "]
["IKBKB"," ","kinase"," ",-1.003,0.000439,"CCL17,Ccl27a,Ccl9,CCNA2,CH25H,GBP3,HLA-A,IFI16,KIF23,LCN2,NOS2,RAG1,SELE,SFRP1,Slfn2","97 (12)"]
["IFNE"," ","cytokine"," ",-1,0.00928,"IFIH1,STAT4,TRIM5,ZBP1"," "]
["TET2"," ","enzyme"," ",1,0.000806,"4930412C18Rik,APOBR,C5AR1,HAL,IFI16,IFIT3,ITGA2,ITGAX,SPINT1"," "]
["TAB1"," ","enzyme"," ",1,0.00193,"CH25H,IFIH1,SAA1,SELE"," "]
["AHR"," ","ligand-dependent nuclear receptor"," ",1.05,0.0474,"CCNA2,ENO1,Gm21596/Hmgb1,HP,IGHM,IL21,IL22,MYL2,Nat8f5,NOS2,SAA1,Smlr1"," "]
["IL13"," ","cytokine"," ",1.132,0.0226,"BCL2A1,CCL17,Ccl27a,DUOX1,FPR2,IL21,IL31RA,LILRB3,MMP12,NOS2,SLPI,SPINT1,TLR1,VNN1"," "]
["GATA2"," ","transcription regulator"," ",1.134,0.00148,"AZGP1,CSTA,CYP11A1,DDX4,EPX,GCSAM,Gm5111,GP9,HBA1/HBA2,HBQ1,ITGA2,LCN2,Ly6a (includes others),PRRG4,RAG1,RHCE/RHD,TSPO2"," "]
["IFN alpha/beta"," ","group"," ",1.187,0.000958,"HLA-A,IFI16,IFIT3,Ly6a (includes others),NOS2,SLPI,TLR1","89 (9)"]
["STAT6"," ","transcription regulator"," ",1.635,6.27e-05,"CCL17,CNR2,FCGR3A/FCGR3B,GBP3,GBP6,H2-T22,HLA-DMB,IFI16,IFIH1,IFIT3,IL31RA,LACC1,Ly6a (includes others),MMP12,Ms4a4c (includes others),SELE,SELENBP1,STAT4,Trim30a/Trim30d,ZBP1","110 (11)"]
["GATA6"," ","transcription regulator"," ",1.706,0.0128,"AMHR2,ATP6V0C,CYP11A1,EVPL,HBA1/HBA2,LEFTY1,MYH6,RBPJL,SLPI"," "]
["AKT1"," ","kinase"," ",1.809,0.11,"BCL2A1,Ccl9,ENO1,LCN2,MYH6,NOS2,PDCD1,PLG,RAG1"," "]
["EGLN"," ","group"," ",1.816,0.0939,"Apol11b (includes others),LCN2,PPP1R3E,SAA1,SELENBP1,Serpina3g (includes others)"," "]
["NR3C1"," ","ligand-dependent nuclear receptor"," ",1.886,1,"ANGPTL7,APOA2,CARD10,CYP11A1,IFIH1,IL7R,MYOC,NOS2,SELE,SRD5A2,TLR1,Trim30a/Trim30d"," "]
["IL12 (family)"," ","group"," ",1.947,0.0107,"CCR6,FCGR3A/FCGR3B,GIMAP4,IL21,IL22,PDCD1,STAT4"," "]
["BAX"," ","transporter"," ",1.98,0.019,"H2-T10,HLA-A,MMP12,TRIM6-TRIM34"," "]
["SP110"," ","transcription regulator","Activated",2,0.23,"ACP1,IFIH1,IFIT3,TRIM5"," "]
["HOXA10"," ","transcription regulator","Activated",2,0.462,"CSTA,CYP2E1,LCN2,SCOC"," "]
["MAPK1"," ","kinase","Activated",2.01,0.0205,"CD84,CSTA,DMP1,DNAH7,HBA1/HBA2,HLA-E,IFI16,IFIH1,IFIT3,MSH5,NOS2,Serpina3g (includes others),TRIM5"," "]
["ESR2"," ","ligand-dependent nuclear receptor","Activated",2.01,0.131,"BSND,CCNA2,CYP11A1,Fbxw21 (includes others),FGF19,HPGD,ITGA2,MYH6,NOS2,OOEP,SELE,THBS4"," "]
["ADORA2A"," ","G-protein coupled receptor","Activated",2.213,0.123,"CCL17,HBA1/HBA2,NOS2,PDCD1,SELE"," "]
["HRAS"," ","enzyme","Activated",2.219,1,"CCNA2,CSTA,CYP24A1,Ifi202b,IL7R,let-7,NOS2,PCDHGA11,Serpina3g (includes others)"," "]
["EBI3"," ","cytokine","Activated",2.377,1.14e-06,"CCR6,EOMES,HLA-A,HLA-DMB,HLA-DOB,HLA-DRA,IL21,IL22,PDCD1","87 (8)"]
["ACOX1"," ","enzyme","Activated",2.421,0.0605,"ACAA1,HAL,HLA-DRB5,LCN2,SELENBP1,SLC22A25"," "]
["IL27"," ","cytokine","Activated",2.424,0.000144,"CCR6,EOMES,HLA-A,HLA-DMB,HLA-DOB,HLA-DRA,HLA-E,HPGD,IL21,IL22,NOS2","118 (14)"]