Table S2: Differentially abundant CAZymes for PDX. difference in median foldchange uncorrected p-value corrected p-value cazyme 0.858619 0.000242543 0.001650477 CE11.hmm UDP-3-0-acyl N-acetylglucosamine deacetylase (EC 3.5.1.-). 1.308783 0.000179532 0.001539071 "GH15.hmm glucoamylase (EC 3.2.1.3); glucodextranase (EC 3.2.1.70); alpha,alpha-trehalase (EC 3.2.1.28); dextran dextrinase (EC 2.4.1.2)" 0.633749 0.0026154 0.008584667 CBM57.hmm Created from reading Schallus et al (2008) Mol Biol Cell. 19:3404-3414 [PMID: 18524852] and finding related domains attached to various glycosidases. 0.380007 0.001099908 0.004649611 "GH35.hmm beta-galactosidase (EC 3.2.1.23); exo-beta-glucosaminidase (EC 3.2.1.165); exo-beta-1,4-galactanase (EC 3.2.1.-); beta-1,3-galactosidase (EC 3.2.1.-)" 0.12868 0.00308775 0.009572025 "PL14.hmm alginate lyase (EC 4.2.2.3); exo-oligoalginate lyase (EC 4.2.2.-); beta-1,4-glucuronan lyase (EC 4.2.2.14)" 0.335515 0.001708899 0.006357104 "GH38.hmm alpha-mannosidase (EC 3.2.1.24); mannosyl-oligosaccharide alpha-1,2-mannosidase (EC 3.2.1.113); mannosyl-oligosaccharide alpha-1,3-1,6-mannosidase (EC 3.2.1.114); alpha-2-O-mannosylglycerate hydrolase (EC 3.2.1.170); mannosyl-oligosaccharide alpha-1,3-mannosidase (EC 3.2.1.-)" 0.628224 3.29E-05 0.001094627 CBM38.hmm The inulin-binding function has been demonstrated in the case of the cycloinulo-oligosaccharide fructanotransferase from Paenibacillus macerans (Bacillus macerans) by Lee et al. (2004) FEMS Microbiol Lett 234:105-10. (PMID:15109727). 0.67856 0.000578657 0.002989727 GT9.hmm lipopolysaccharide N-acetylglucosaminyltransferase (EC 2.4.1.56); heptosyltransferase (EC 2.4.-.-). 0.558869 0.00019859 0.001539071 "GH93.hmm exo-alpha-L-1,5-arabinanase (EC 3.2.1.-)" 0.570935 0.000764793 0.003678919 CBM9.hmm Modules of approx. 170 residues found so far only in xylanases. The cellulose-binding function has been demonstrated in one case. 1.333813 7.04E-05 0.001156099 GH116.hmm beta-glucosidase (EC 3.2.1.21); beta-xylosidase (EC 3.2.1.37); acid beta-glucosidase/beta-glucosylceramidase (EC 3.2.1.45); beta-N-acetylglucosaminidase (EC 3.2.1.52) 0.842816 1.49E-05 0.001094627 "PL20.hmm endo-beta-1,4-glucuronan lyase (EC 4.2.2.14)" 0.753106 4.10E-05 0.001094627 "GH5.hmm endo-beta-1,4-glucanase / cellulase (EC 3.2.1.4); endo-beta-1,4-xylanase (EC 3.2.1.8); beta-glucosidase (EC 3.2.1.21); beta-mannosidase (EC 3.2.1.25); beta-glucosylceramidase (EC 3.2.1.45); glucan beta-1,3-glucosidase (EC 3.2.1.58); licheninase (EC 3.2.1.73); exo-beta-1,4-glucanase / cellodextrinase (EC 3.2.1.74); glucan endo-1,6-beta-glucosidase (EC 3.2.1.75); mannan endo-beta-1,4-mannosidase (EC 3.2.1.78); cellulose beta-1,4-cellobiosidase (EC 3.2.1.91); steryl beta-glucosidase (EC 3.2.1.104); endoglycoceramidase (EC 3.2.1.123); chitosanase (EC 3.2.1.132); beta-primeverosidase (EC 3.2.1.149); xyloglucan-specific endo-beta-1,4-glucanase (EC 3.2.1.151); endo-beta-1,6-galactanase (EC 3.2.1.164); hesperidin 6-O-alpha-L-rhamnosyl-beta-glucosidase (EC 3.2.1.168); beta-1,3-mannanase (EC 3.2.1.-); arabinoxylan-specific endo-beta-1,4-xylanase (EC 3.2.1.-); mannan transglycosylase (EC 2.4.1.-)" -0.447294 0.001566636 0.006244165 GH25.hmm lysozyme (EC 3.2.1.17) 1.526488 4.10E-05 0.001094627 AA5.hmm Oxidase with oxygen as acceptor (EC 1.1.3.-); galactose oxidase (EC 1.1.3.9); glyoxal oxidase (EC 1.2.3.15); alcohol oxidase (EC 1.1.3.13) 0.095838 0.001099908 0.004649611 GH75.hmm chitosanase (EC 3.2.1.132) 0.629743 0.000295502 0.001917325 PL1.hmm pectate lyase (EC 4.2.2.2); exo-pectate lyase (EC 4.2.2.9); pectin lyase (EC 4.2.2.10). 0.794319 0.000146459 0.001459361 CBM69.hmm starch-binding function demonstrated in one case; distantly related to families CBM20 and CBM48 0.095838 0.001099908 0.004649611 CBM47.hmm Modules of approx 150 residues. Fucose-binding activity demonstrated -0.478806 0.001708899 0.006357104 GT35.hmm glycogen or starch phosphorylase (EC 2.4.1.1). 0.683938 0.00019859 0.001539071 CBM20.hmm The granular starch-binding function has been demonstrated in several cases. Interact strongly with cyclodextrins. Often designated as starch-binding domains (SBD). 0.537833 0.000526647 0.002772348 "GT90.hmm UDP-Xyl: (mannosyl) glucuronoxylomannan/galactoxylomannan beta-1,2-xylosyltransferase (EC 2.4.2.-); UDP-Glc: protein O-beta-glucosyltransferase (EC 2.4.1.-); UDP-Xyl: protein O-beta-xylosyltransferase (EC 2.4.2.-)" 0.685073 9.34E-06 0.001094627 "GH30.hmm endo-beta-1,4-xylanase (EC 3.2.1.8); beta-glucosidase (3.2.1.21); beta-glucuronidase (EC 3.2.1.31); beta-xylosidase (EC 3.2.1.37); beta-fucosidase (EC 3.2.1.38); glucosylceramidase (EC 3.2.1.45); beta-1,6-glucanase (EC 3.2.1.75); glucuronoarabinoxylan endo-beta-1,4-xylanase (EC 3.2.1.136); endo-beta-1,6-galactanase (EC:3.2.1.164); [reducing end] beta-xylosidase (EC 3.2.1.-)" 1.169476 0.001005304 0.004598031 GH139.hmm alpha-2-O-Me-L-fucosidase (EC 3.2.1.-) 0.430113 0.000697322 0.003537323 PL9.hmm pectate lyase (EC 4.2.2.2); exopolygalacturonate lyase (EC 4.2.2.9); thiopeptidoglycan lyase (EC 4.2.2.-). 0.727618 0.001099908 0.004649611 "GT7.hmm lactose synthase (EC 2.4.1.22); beta-N-acetylglucosaminyl-glycopeptide beta-1,4-galactosyltransferase (EC 2.4.1.38); N-acetyllactosamine synthase (EC 2.4.1.90); xylosylprotein beta-4-galactosyltransferase (EC 2.4.1.133); UDP-Gal: neolactotriaosylceramide beta-1,4-galactosyltransferase (EC 2.4.1.275); beta-1,4-N-acetylglucosaminyltransferase (EC 2.4.1.-)" 0.907226 0.00047902 0.002620522 PL15.hmm oligo-alginate lyase (EC 4.2.2.-); alginate lyase (EC 4.2.2.3) 1.055365 0.000219536 0.001611856 GH147.hmm beta-galactosidase (EC 3.2.1.23) 0.8175 0.000107419 0.00124875 PL13.hmm heparin lyase (EC 4.2.2.7) 1.03128 2.35E-05 0.001094627 "GT25.hmm lipopolysaccharide beta-1,4-galactosyltransferase (EC 2.4.1.-); beta-1,3-glucosyltransferase (EC 2.4.1.-); beta-1,2-glucosyltransferase (EC 2.4.1.-); beta-1,2-galactosyltransferase (EC 2.4.1.-); LPS beta-1,4-galactosyltransferase (EC 2.4.1.-); occidiofungin beta-xylosyltransferase (EC 2.4.2.-); UDP-Gal:procollagen beta-galactosyltransferase (EC 2.4.1.50)" 0.748165 0.000162204 0.001539071 PL22.hmm oligogalacturonate lyase / oligogalacturonide lyase (EC 4.2.2.6) 0.579242 0.001708899 0.006357104 "GT76.hmm Dol-P-Man: alpha-1,6-mannosyltransferase (EC 2.4.1.-)" 0.012389 0.00221 0.007519392 GH47.hmm alpha-mannosidase (EC 3.2.1.113) 0.240795 0.001862957 0.006750197 PL10.hmm pectate lyase (EC 4.2.2.2) 0.771119 0.001435352 0.005803814 GH150.hmm l-carrageenase (EC 3.2.1.-) 0.843629 0.000435436 0.00253097 "GT20.hmm alpha,alpha-trehalose-phosphate synthase [UDP-forming] (EC 2.4.1.15); Glucosylglycerol-phosphate synthase (EC 2.4.1.213); trehalose-6-P phosphatase (EC 3.1.3.12); [retaining] GDP-valeniol: validamine 7-phosphate valeniolyltransferase (EC 2.-.-.-)" 0.318855 0.00308775 0.009572025 "GH76.hmm alpha-1,6-mannanase (EC 3.2.1.101)" 0.773697 7.04E-05 0.001156099 "GH144.hmm endo-beta-1,2-glucanase (EC 3.2.1.71)" 0.269886 0.002842629 0.009116019 "GH125.hmm exo-alpha-1,6-mannosidase (EC 3.2.1.-)" 0.63146 0.000267798 0.001778943 GT45.hmm alpha-N-acteylglucosaminyltransferase (EC 2.4.1.-) 0.473977 0.000242543 0.001650477 GH66.hmm cycloisomaltooligosaccharide glucanotransferase (EC 2.4.1.248); dextranase (EC 3.2.1.11). 0.636547 0.001202687 0.005008204 CBM44.hmm The C-terminal CBM44 module of the Clostridium thermocellum enzyme has been demonstrated to bind equally well cellulose and xyloglucan 0.824318 4.10E-05 0.001094627 GT3.hmm glycogen synthase (EC 2.4.1.11). 1.043355 0.000107419 0.00124875 "GH117.hmm alpha-1,3-L-neoagarooligosaccharide hydrolase (EC 3.2.1.-); alpha-1,3-L-neoagarobiase / neoagarobiose hydrolase (EC 3.2.1.-)" 1.009828 0.000359146 0.002226707 GH137.hmm beta-L-arabinofuranosidase (EC 3.2.1.185) 1.186012 5.10E-05 0.001094627 "GT10.hmm galactoside alpha-1,3/1,4-L-fucosyltransferase (EC 2.4.1.65); galactoside alpha-1,3-L-fucosyltransferase (EC 2.4.1.152); glycoprotein alpha-1,3-L-fucosyltransferase (EC 2.4.1.214)" 0.77996 0.000918282 0.004270011 PL17.hmm alginate lyase (EC 4.2.2.3); oligoalginate lyase (EC 4.2.2.-) 1.110708 4.10E-05 0.001094627 "GH145.hmm L-Rhalpha-alpha-1,4-GlcA alpha-L-rhamnohydrolase (EC 3.2.1.-)" 0.447153 0.000838285 0.003964092 "GT94.hmm GDP-Man: GlcA-beta-1,2-Man-alpha-1,3-Glc-beta-1,4-Glc-alpha-1-PP-undecaprenol beta-1,4-mannosyltransferase (2.4.1.251)" 1.833311 9.68E-05 0.00124875 "GT102.hmm dTDP-beta-L-Rhap : O-antigen-polysaccharide alpha-1,3-L-rhamnosyltransferase (EC 2.4.1.289)" 1.326878 1.67E-05 0.001094627 PL5.hmm alginate lyase (EC 4.2.2.3). 0.485226 0.002404892 0.007987677 "GT6.hmm alpha-1,3-galactosyltransferase (EC 2.4.1.87); alpha-1,3 N-acetylgalactosaminyltransferase (EC 2.4.1.40); alpha-galactosyltransferase (EC 2.4.1.37); globoside alpha-N-acetylgalactosaminyltransferase (EC 2.4.1.88)." 1.069323 0.00019859 0.001539071 GT30.hmm CMP-beta-KDO: alpha-3-deoxy-D-manno-octulosonic-acid (KDO) transferase (EC 2.4.99.-). -0.543018 0.000395576 0.002399254 "GH1.hmm beta-glucosidase (EC 3.2.1.21); beta-galactosidase (EC 3.2.1.23); beta-mannosidase (EC 3.2.1.25); beta-glucuronidase (EC 3.2.1.31); beta-xylosidase (EC 3.2.1.37); beta-D-fucosidase (EC 3.2.1.38); phlorizin hydrolase (EC 3.2.1.62); exo-beta-1,4-glucanase (EC 3.2.1.74); 6-phospho-beta-galactosidase (EC 3.2.1.85); 6-phospho-beta-glucosidase (EC 3.2.1.86); strictosidine beta-glucosidase (EC 3.2.1.105); lactase (EC 3.2.1.108); amygdalin beta-glucosidase (EC 3.2.1.117); prunasin beta-glucosidase (EC 3.2.1.118); vicianin hydrolase (EC 3.2.1.119); raucaffricine beta-glucosidase (EC 3.2.1.125); thioglucosidase (EC 3.2.1.147); beta-primeverosidase (EC 3.2.1.149); isoflavonoid 7-O-beta-apiosyl-beta-glucosidase (EC 3.2.1.161); ABA-specific beta-glucosidase (EC 3.2.1.175); DIMBOA beta-glucosidase (EC 3.2.1.182); beta-glycosidase (EC 3.2.1.-); hydroxyisourate hydrolase (EC 3.-.-.-)" 1.225216 4.57E-05 0.001094627 GH57.hmm alpha-amylase (EC 3.2.1.1); alpha-galactosidase (EC 3.2.1.22); amylopullulanase (EC 3.2.1.41); cyclomaltodextrinase (EC 3.2.1.54); branching enzyme (EC 2.4.1.18); 4-alpha-glucanotransferase (EC 2.4.1.25) -0.390891 0.00221 0.007519392 "GH112.hmm lacto-N-biose phosphorylase or galacto-N-biose phosphorylase (EC 2.4.1.211); D-galactosyl-beta-1,4-L-rhamnose phosphorylase (EC 2.4.1.247); galacto-N-biose/lacto-N-biose phosphorylase (EC 2.4.1.-)" 0.482561 0.000219536 0.001611856 "PL27.hmm L-rhamnose-alpha-1,4-D-glucuronate lyase (EC 4.2.2.-)" 0.411715 0.00221 0.007519392 "GT17.hmm beta-1,4-mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyltransferase (EC 2.4.1.144)." 0.168179 0.001862957 0.006750197 GH126.hmm alpha-amylase (EC 3.2.1.-) 0.910008 7.84E-05 0.001214457 PL8.hmm hyaluronate lyase (EC 4.2.2.1); chondroitin AC lyase (EC 4.2.2.5); xanthan lyase (EC 4.2.2.12); chondroitin ABC lyase (EC 4.2.2.20) 1.283882 0.000146459 0.001459361 GH141.hmm alpha-L-fucosidase (EC 3.2.1.51); xylanase (EC 3.2.1.8) 0.829565 0.000435436 0.00253097 GH138.hmm alpha-galacturonidase (EC 3.2.1.-) 0.876609 0.000107419 0.00124875 "CBM62.hmm The CBM62 module of Clostridium thermocellum Cthe_2193 protein binds galactose moieties found on xyloglucan, arabinogalactan and galactomannan." 0.234531 0.002404892 0.007987677 GH106.hmm alpha-L-rhamnosidase (EC 3.2.1.40); rhamnogalacturonan alpha-L-rhamnohydrolase (EC 3.2.1.174) 1.195452 0.000242543 0.001650477 GH142.hmm beta-L-arabinofuranosidase (EC 3.2.1.185) 0.393677 0.000764793 0.003678919 GH52.hmm beta-xylosidase (EC 3.2.1.37). 0.325959 0.002029683 0.00726002 "CBM72.hmm Modules of 130-180 residues found at the C-terminus glycoside hydrolases from various families, sometimes as tandem repeats. The CBM72 found on an endoglucanase from an uncultivated microorganism was found to bind a broad spectrum of polysaccharides including soluble" 0.081613 0.000179532 0.001539071 PL6.hmm alginate lyase (EC 4.2.2.3); chondroitinase B (EC 4.2.2.19); MG-specific alginate lyase (EC 4.2.2.-) 0.095838 0.001099908 0.004649611 "GT31.hmm N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase (EC 2.4.1.149); Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase (EC 2.4.1.122); fucose-specific beta-1,3-N-acetylglucosaminyltransferase (EC 2.4.1.-); globotriosylceramide beta-1,3-GalNAc transferase (EC 2.4.1.79); chondroitin synthase (beta-1,3-GlcUA and beta-1,4-GalNAc transferase (EC 2.4.1.175); chondroitin beta-1,3-glucuronyltransferase (EC 2.4.1.226); chondroitin beta-1,4-N-acetylgalactosaminyltransferase (EC 2.4.1.-); UDP-Gal: beta-galactosylxylosylprotein beta-1,3-galactosyltransferase (EC 2.4.1.134); UDP-GlcNAc: O-fucosylpeptide beta-1,3-N-acetylglucosaminyltransferase (EC 2.4.1.222)" 0.853648 5.10E-05 0.001094627 GT70.hmm UDP-GlcA: beta-glucuronosyltransferase (EC 2.4.1.17) 0.184329 0.000107419 0.00124875 "GT74.hmm alpha-1,2-L-fucosyltransferase (EC 2.4.1.69)" 1.235083 8.71E-05 0.00124875 GH108.hmm N-acetylmuramidase (EC 3.2.1.17) 0.012389 0.00221 0.007519392 "GH49.hmm dextranase (EC 3.2.1.11); isopullulanase (EC 3.2.1.57); dextran 1,6-alpha-isomaltotriosidase (EC 3.2.1.95)." 0.765192 0.000119186 0.00133012 "GT80.hmm beta-galactoside alpha-2,6-sialyltransferase (EC 2.4.99.1); beta-galactoside alpha-2,3-sialyltransferase (EC 2.4.99.4)" 0.365495 0.00047902 0.002620522 "GH99.hmm glycoprotein endo-alpha-1,2-mannosidase (EC 3.2.1.130); mannan endo-1,2-alpha-mannanase (3.2.1.-)" -0.394022 0.000359146 0.002226707 AA3.hmm cellobiose dehydrogenase (EC 1.1.99.18); glucose 1-oxidase (EC 1.1.3.4); aryl alcohol oxidase (EC 1.1.3.7); alcohol oxidase (EC 1.1.3.13); pyranose oxidase (EC 1.1.3.10); pyranose dehydrogenase (EC 1.1.99.29) 0.366732 0.000526647 0.002772348 "GH26.hmm beta-mannanase (EC 3.2.1.78); exo-beta-1,4-mannobiohydrolase (EC 3.2.1.100); beta-1,3-xylanase (EC 3.2.1.32); lichenase / endo-beta-1,3-1,4-glucanase (EC 3.2.1.73); mannobiose-producing exo-beta-mannanase (EC 3.2.1.-)" 0.350694 0.00308775 0.009572025 "GH55.hmm exo-beta-1,3-glucanase (EC 3.2.1.58); endo-beta-1,3-glucanase (EC 3.2.1.39)" 1.094325 0.00047902 0.002620522 GH143.hmm 2-keto-3-deoxy-D-lyxo-heptulosaric acid hydrolase (EC 3.2.1.-) -0.417089 0.001708899 0.006357104 CBM27.hmm Mannan-binding function demonstrated in two cases 0.345329 0.002842629 0.009116019 "GT92.hmm UDP-Gal: N-glycan core alpha-1,6-fucoside beta-1,4-galactosyltransferase (EC 2.4.1.-); UDP-Gal: beta-galactoside beta-1,4-galactosyltransferase (EC 2.4.1.-)" 0.986803 5.68E-05 0.001132644 "GH67.hmm alpha-glucuronidase (EC 3.2.1.139); xylan alpha-1,2-glucuronidase (EC 3.2.1.131)" 1.083054 2.35E-05 0.001094627 "GT82.hmm UDP-GalNAc: beta-1,4-N-acetylgalactosaminyltransferase (EC 2.4.1.-)"