{"text_format":"3","workbook":"xlsx","n_sheets":22,"sheets":["SOM Table 1","SOM Table 2","SOM Table 3","SOM Table 4","SOM Table 5","SOM Table 6","SOM Table 7","SOM Table 8","SOM Table 9","SOM Table 10","SOM Table 11","SOM Table 12","SOM Table 13","SOM Table 14","SOM Table 15","SOM Table 16","SOM Table 17","SOM Table 18","SOM Table 19","SOM Table 20","SOM Table 21","SOM Table 22"],"not_rendered":{"defined_names":3},"read":"whole","date_system":"1900"}

{"sheet":"SOM Table 1","index":0,"n_rows":32,"n_cols":6,"rows_kept":32,"merged":[[31,0,31,5]]}
["Sample ID","Group","Diagnosis","Gender","Methylation","Expression"]
[29,"ALH","BD","Female","X","X"]
[45,"ALH","MDD","Female","X"]
[47,"ALH","BD","Female","X","X"]
[48,"ALH","MDD","Male","X","X"]
[55,"ALH","MDD","Female","X","X"]
[57,"ALH","BD","Male","X","X"]
[61,"ALH","BD","Male","X"]
[63,"ALH","MDD","Female","X","X"]
[99,"ALH","BD","Male","X","X"]
[163,"ALH","MDD","Male",null,"X"]
[11,"MI","NA","Female","X","X"]
[13,"MI","NA","Female","X","X"]
[33,"MI","NA","Male","X","X"]
[39,"MI","NA","Male","X","X"]
[46,"MI","NA","Male","X","X"]
[49,"MI","NA","Female",null,"X"]
[70,"MI","NA","Female","X","X"]
[98,"MI","NA","Female","X","X"]
[141,"MI","NA","Female","X"]
[22,"ULH","NA","Female","X","X"]
[36,"ULH","NA","Female","X","X"]
[42,"ULH","NA","Female","X","X"]
[54,"ULH","NA","Male","X","X"]
[58,"ULH","NA","Male","X","X"]
[69,"ULH","NA","Male","X","X"]
[73,"ULH","NA","Male","X","X"]
[76,"ULH","NA","Male","X","X"]
[97,"ULH","NA","Male","X","X"]
[103,"ULH","NA","Male","X","X"]
[]
["SOM Table 1. Individuals included in this study. Shown are the group (ALH, ULH or MI) and gender of each participant in the study. The columns \"Methylation\" and \"Expression\" indicate whether methylation or FANCI expression data, respectively, were successfully obtained from each sample."]

{"sheet":"SOM Table 2","index":1,"n_rows":16,"n_cols":9,"rows_kept":16,"merged":[[15,0,15,8]]}
["Method","DMRSE_score","GCOSE_score","Seabi_score","DMRSE_rank","GCOSE_rank","Seabi_rank","mean_rank","rank_of_means"]
["daten2",0.001739573,0.000143,0.05661123,1,3,2,2,1]
["daten1",1.761341E-3,0.00014,0.05699144,3,2,5,3.33,2]
["dasen",0.00175725,1.47E-4,0.05697038,2,5,4,3.67,3]
["naten",1.769744E-3,1.15E-4,0.05764031,4,1,7,4,4]
["nanet",0.001835999,1.46E-4,0.05677118,7,4,3,4.67,5]
["nasen",0.001784752,0.000149,0.05744798,5,6,6,5.67,6]
["BMIQ",0.004490105,1.654499E-4,0.05611816,11,12,1,8,7.5]
["danet",0.001796641,0.00015,0.05916194,6,8,10,8,7.5]
["raw",0.00486209,0.0001492697,0.05859456,12,7,8,9,9]
["danes",0.001909468,0.000153,0.06061546,8,10,11,9.67,10]
["danen",0.004949165,0.00015,0.05897272,13,9,9,10.33,11]
["nanes",0.001936443,1.55E-4,0.06108984,9,11,12,10.67,12]
["tost",2.702589E-3,2.493757E-4,0.06366096,10,13,13,12,13]
[]
["SOM Table 2. The dataset was normalised using 12 different normalisation methods and assessed using three metrics, DMRSE, GCOSE and Seabi, available in the wateRmelon package (Pidsley et al., 2013). Performance on each method was ranked (with a lower rank indicating better performance) and the three ranks were normalised. The normalised ranks were then ranked to identify the best performing normalisation method. For comparison, the raw (pre-normalisation) dataset was also assessed. "]

{"sheet":"SOM Table 3","index":2,"n_rows":23436,"n_cols":9,"rows_kept":4500,"cut":true,"merged":[[23435,0,23435,8]],"bounds":{"rows_first":2000,"rows_last":500,"rows_between":2000,"halvings":0}}
["Probe ID","Gene symbol","Chr.","Coordinatea","p-value","Adjusted p-valueb","MI β (mean)","LH β (mean)","β differencec"]
["cg12858231","FANCI;FANCI",15,89846095,2.53923846663515e-07,0.0559773399729089,{"v":0.78112434212209,"d":"0.78"},{"v":0.816768941505156,"d":"0.82"},{"v":0.0356445993830657,"d":"0.04"}]
["cg09354556",null,3,47051341,2.99290753843758e-07,0.0559773399729089,{"v":0.298685533484014,"d":"0.30"},{"v":0.243541633478551,"d":"0.24"},{"v":-0.0551439000054634,"d":"-0.06"}]
["cg22708112","GCOM1;GCOM1;GCOM1;GCOM1",15,57883392,3.85319841493091e-07,0.0559773399729089,{"v":0.820541150626641,"d":"0.82"},{"v":0.715544207173815,"d":"0.72"},{"v":-0.104996943452827,"d":"-0.10"}]
["cg12251573","AHRR",5,421644,6.57908985020584e-07,0.0716832958491491,{"v":0.698626096924077,"d":"0.70"},{"v":0.847555253461926,"d":"0.85"},{"v":0.148929156537849,"d":"0.15"}]
["cg14130272","BAT1;SNORD84;BAT1",6,31509427,1.39143686288793e-06,0.105553830885865,{"v":0.21170928082564,"d":"0.21"},{"v":0.150377752775995,"d":"0.15"},{"v":-0.0613315280496447,"d":"-0.06"}]
["cg09420907",null,12,4273763,1.4531589177197E-6,0.105553830885865,{"v":0.242366826160993,"d":"0.24"},{"v":0.273749444673932,"d":"0.27"},{"v":0.0313826185129388,"d":"0.03"}]
["cg23936031","HOXA5",7,27183133,2.02198499976301E-6,0.125890230360245,{"v":0.784793706296721,"d":"0.78"},{"v":0.681005219794067,"d":"0.68"},{"v":-0.103788486502654,"d":"-0.10"}]
["cg04985482","MICA",6,31382065,3.18460694263591e-06,0.165388404861024,{"v":0.873183999978685,"d":"0.87"},{"v":0.7716849627092,"d":"0.77"},{"v":-0.101499037269485,"d":"-0.10"}]
["cg17432857","HOXA5",7,27184438,3.93671857699785e-06,0.165388404861024,{"v":0.782321308912851,"d":"0.78"},{"v":0.690022911426375,"d":"0.69"},{"v":-0.0922983974864763,"d":"-0.09"}]
["cg13512268","HOXA5",7,27183973,4.13817669005696E-6,0.165388404861024,{"v":0.880683763740399,"d":"0.88"},{"v":0.831202013054841,"d":"0.83"},{"v":-0.0494817506855588,"d":"-0.05"}]
["cg04824913","GAK",4,887549,4.42648815043086e-06,0.165388404861024,{"v":0.782866224577412,"d":"0.78"},{"v":0.85574728155176,"d":"0.86"},{"v":0.0728810569743479,"d":"0.07"}]
["cg01323381","HOXA5",7,27184264,5.20495467865912e-06,0.165388404861024,{"v":0.829710886828012,"d":"0.83"},{"v":0.771747687023747,"d":"0.77"},{"v":-0.0579631998042649,"d":"-0.06"}]
["cg14058329","HOXA5",7,27183946,5.77972603384275e-06,0.165388404861024,{"v":0.897875069652031,"d":"0.90"},{"v":0.837854242463025,"d":"0.84"},{"v":-0.0600208271890063,"d":"-0.06"}]
["cg03832522",null,2,218898668,6.1095805508271e-06,0.165388404861024,{"v":0.28140047435551,"d":"0.28"},{"v":0.350111708680988,"d":"0.35"},{"v":0.0687112343254787,"d":"0.07"}]
["cg23454797","HOXA5",7,27183990,6.75113406677537e-06,0.165388404861024,{"v":0.865647397133257,"d":"0.87"},{"v":0.807290888219646,"d":"0.81"},{"v":-0.0583565089136115,"d":"-0.06"}]
["cg15358701",null,1,161410459,6.81212178067613e-06,0.165388404861024,{"v":0.14791250457267,"d":"0.15"},{"v":0.117895922816747,"d":"0.12"},{"v":-0.0300165817559226,"d":"-0.03"}]
["cg00703898",null,16,34299638,7.39627490435596e-06,0.165388404861024,{"v":0.677709700023048,"d":"0.68"},{"v":0.634273982001747,"d":"0.63"},{"v":-0.0434357180213008,"d":"-0.04"}]
["cg09715059",null,6,32223336,7.4879490585144e-06,0.165388404861024,{"v":0.389598769447631,"d":"0.39"},{"v":0.498806912866143,"d":"0.50"},{"v":0.109208143418512,"d":"0.11"}]
["cg17192377","HDHD2",18,44677553,7.62298687556795e-06,0.165388404861024,{"v":0.42059158496617,"d":"0.42"},{"v":0.490217462275219,"d":"0.49"},{"v":0.0696258773090491,"d":"0.07"}]
["cg12176783","TCEA2;TCEA2",20,62694000,7.8440461249969E-6,0.165388404861024,{"v":0.71570452055991,"d":"0.72"},{"v":0.653142861579954,"d":"0.65"},{"v":-0.0625616589799557,"d":"-0.06"}]
["cg25307665","HOXA5",7,27183694,8.13509744406668E-6,0.165388404861024,{"v":0.684743196508821,"d":"0.68"},{"v":0.538851001867554,"d":"0.54"},{"v":-0.145892194641266,"d":"-0.15"}]
["cg08397993","NCRNA00171",6,29981250,8.46469621677138e-06,0.165388404861024,{"v":0.28951931932148,"d":"0.29"},{"v":0.404366796171118,"d":"0.40"},{"v":0.114847476849638,"d":"0.11"}]
["cg17569124","HOXA5",7,27183643,9.19241118564994e-06,0.165388404861024,{"v":0.72041443072704,"d":"0.72"},{"v":0.59296908747723,"d":"0.59"},{"v":-0.127445343249811,"d":"-0.13"}]
["cg24524379","LRRC2;LRRC2",3,46600244,9.45416497162438e-06,0.165388404861024,{"v":0.279055949672116,"d":"0.28"},{"v":0.379497576636147,"d":"0.38"},{"v":0.100441626964031,"d":"0.10"}]
["cg03946671","TCEA2;TCEA2",20,62693973,9.9557275989088e-06,0.165388404861024,{"v":0.851345177320683,"d":"0.85"},{"v":0.807667900211821,"d":"0.81"},{"v":-0.0436772771088619,"d":"-0.04"}]
["cg25215230",null,4,15679598,1.03093688669648E-5,0.165388404861024,{"v":0.825605510959573,"d":"0.83"},{"v":0.773914256238197,"d":"0.77"},{"v":-0.0516912547213763,"d":"-0.05"}]
["cg01370449","HOXA5",7,27183369,1.06859112565689e-05,0.165388404861024,{"v":0.781988480009998,"d":"0.78"},{"v":0.708075216684159,"d":"0.71"},{"v":-0.0739132633258389,"d":"-0.07"}]
["cg11103845","PBX2",6,32157230,1.09711405667272e-05,0.165388404861024,{"v":0.175678496275575,"d":"0.18"},{"v":0.20407584180004,"d":"0.20"},{"v":0.0283973455244657,"d":"0.03"}]
["cg09755872",null,7,23245557,1.11728193728951e-05,0.165388404861024,{"v":0.439485428501205,"d":"0.44"},{"v":0.496824113796531,"d":"0.50"},{"v":0.0573386852953263,"d":"0.06"}]
["cg08513547","LOC134466",5,150323558,1.14447554371665e-05,0.165388404861024,{"v":0.786134959711682,"d":"0.79"},{"v":0.73989408160672,"d":"0.74"},{"v":-0.0462408781049626,"d":"-0.05"}]
["cg09549073","HOXA5;HOXA5",7,27183274,1.17639891027172E-5,0.165388404861024,{"v":0.758113244051209,"d":"0.76"},{"v":0.665794711403546,"d":"0.67"},{"v":-0.092318532647663,"d":"-0.09"}]
["cg02005600","HOXA5",7,27183686,1.31251765376234e-05,0.178758752015928,{"v":0.783767849150154,"d":"0.78"},{"v":0.680399197288056,"d":"0.68"},{"v":-0.103368651862098,"d":"-0.10"}]
["cg24040595","HOXA6",7,27185512,1.41128296103782E-5,0.186385574695245,{"v":0.832610981037207,"d":"0.83"},{"v":0.759631418154575,"d":"0.76"},{"v":-0.0729795628826322,"d":"-0.07"}]
["cg05076221","HOXA5",7,27182637,1.6029384569531E-5,0.205470780294583,{"v":0.668046422663196,"d":"0.67"},{"v":0.573231210611154,"d":"0.57"},{"v":-0.0948152120520422,"d":"-0.09"}]
["cg02916332","HOXA5",7,27183591,1.6880395517592E-5,0.210197096470129,{"v":0.758225838035443,"d":"0.76"},{"v":0.667893131551088,"d":"0.67"},{"v":-0.0903327064843552,"d":"-0.09"}]
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["cg12386194","SENP7;SENP7",3,101231763,2.75845364457035e-05,0.267156235476638,{"v":0.0567639619857378,"d":"0.06"},{"v":0.0671523300795933,"d":"0.07"},{"v":0.0103883680938555,"d":"0.01"}]
["cg19086603","F7;F7",13,113773158,3.04615958203762E-5,0.286934708560122,{"v":0.846099503351853,"d":"0.85"},{"v":0.562775518631044,"d":"0.56"},{"v":-0.283323984720809,"d":"-0.28"}]
["cg10901867","NAT8L",4,2064353,3.23114564731793E-5,0.286934708560122,{"v":0.670956652973658,"d":"0.67"},{"v":0.820158641589676,"d":"0.82"},{"v":0.149201988616018,"d":"0.15"}]
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["cg17448192","ST6GAL1;ST6GAL1",3,186718821,4.12554887190847e-05,0.292111370521422,{"v":0.580449900392568,"d":"0.58"},{"v":0.623996683650212,"d":"0.62"},{"v":0.0435467832576436,"d":"0.04"}]
["cg21920570","MACROD1",11,63766787,4.15554522396103e-05,0.292111370521422,{"v":0.333408349087841,"d":"0.33"},{"v":0.294148904761471,"d":"0.29"},{"v":-0.0392594443263696,"d":"-0.04"}]
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["cg23083776",null,6,32381485,4.51611548210864e-05,0.304443282177683,{"v":0.145003592443133,"d":"0.15"},{"v":0.125289575228951,"d":"0.13"},{"v":-0.0197140172141826,"d":"-0.02"}]
["cg16474696","MRI1;MRI1",19,13875014,4.59293236894292e-05,0.304443282177683,{"v":0.497353455594542,"d":"0.50"},{"v":0.269470256050799,"d":"0.27"},{"v":-0.227883199543743,"d":"-0.23"}]
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["cg25103895","ADO;ADO",10,64565642,0.0499862136579863,0.929715912277851,{"v":0.559143317938833,"d":"0.56"},{"v":0.542373092553428,"d":"0.54"},{"v":-0.0167702253854056,"d":"-0.02"}]
["cg10911980","C3orf39",3,43146909,0.049990707254649,0.929715912277851,{"v":0.445570451647767,"d":"0.45"},{"v":0.46492095821175,"d":"0.46"},{"v":0.0193505065639832,"d":"0.02"}]
["cg00785170","PHLDA3",1,201438757,0.0499911466648909,0.929715912277851,{"v":0.187525882237786,"d":"0.19"},{"v":0.176436778224021,"d":"0.18"},{"v":-0.0110891040137654,"d":"-0.01"}]
["cg02928935",null,17,17188379,0.0499955277923737,0.929715912277851,{"v":0.842983124260333,"d":"0.84"},{"v":0.85583903153625,"d":"0.86"},{"v":0.0128559072759173,"d":"0.01"}]
["cg05954567",null,6,28827930,0.0499965018026189,0.929715912277851,{"v":0.733521477722179,"d":"0.73"},{"v":0.702475683489352,"d":"0.70"},{"v":-0.0310457942328271,"d":"-0.03"}]
["cg05718288",null,5,135526589,0.0499979509562789,0.929715912277851,{"v":0.85451900886562,"d":"0.85"},{"v":0.867675496106359,"d":"0.87"},{"v":0.013156487240739,"d":"0.01"}]
["cg09658342","TIA1;TIA1",2,70476000,0.0499987531904587,0.929715912277851,{"v":0.0950523463099467,"d":"0.10"},{"v":0.0889909127007196,"d":"0.09"},{"v":-0.00606143360922716,"d":"-0.01"}]
[]
["Table 3. Probes attaining an uncorrected p-value of ≤ 0.05 in the comparison of individuals carrying the linked haplotype (LH) and married in controls (MI), ranked by p-value. Where a probe maps to multiple overlapping transcripts these are indicated separated by a semicolon. Adjusted p-values were calculated using Benjamini-Hochberg's False Disovery Rate procedure. aGRCh37/hg16.  bAdjusted p-values were calculated using Benjamini-Hochberg's False Disovery Rate procedure. cLH β mean – MI β mean."]

{"sheet":"SOM Table 4","index":3,"n_rows":23208,"n_cols":9,"rows_kept":4500,"cut":true,"merged":[[23207,0,23207,8]],"bounds":{"rows_first":2000,"rows_last":500,"rows_between":2000,"halvings":0}}
["Probe ID","Gene symbol","Chr.","Coordinatea","p-value","Adjusted p-valueb","MI β (mean)","ALH β (mean)","β differencec"]
["cg09354556",null,3,47051341,{"v":1.93090144171121e-07,"d":"1.93E-07"},0.0711405396147221,{"v":0.298685533484014,"d":"0.30"},{"v":0.235381589883448,"d":"0.24"},{"v":-0.0633039436005667,"d":"-0.06"}]
["cg12858231","FANCI;FANCI",15,89846095,{"v":3.26463785302459e-07,"d":"3.26E-07"},0.0711405396147221,{"v":0.78112434212209,"d":"0.78"},{"v":0.820114370153605,"d":"0.82"},{"v":0.0389900280315143,"d":"0.04"}]
["cg22708112","GCOM1;GCOM1;GCOM1;GCOM1",15,57883392,{"v":8.45271155152453e-07,"d":"8.45E-07"},0.122796767064773,{"v":0.820541150626641,"d":"0.82"},{"v":0.69476989766056,"d":"0.69"},{"v":-0.125771252966081,"d":"-0.13"}]
["cg12251573","AHRR",5,421644,{"v":3.16205764144902e-06,"d":"3.16E-06"},0.34452594289613,{"v":0.698626096924077,"d":"0.70"},{"v":0.85268746488244,"d":"0.85"},{"v":0.154061367958362,"d":"0.15"}]
["cg21920570","MACROD1",11,63766787,{"v":5.28253115565131e-06,"d":"5.28E-06"},0.410742627113955,{"v":0.333408349087841,"d":"0.33"},{"v":0.284976928598718,"d":"0.28"},{"v":-0.0484314204891227,"d":"-0.05"}]
["cg04824913","GAK",4,887549,{"v":6.26751851720306e-06,"d":"6.27E-06"},0.410742627113955,{"v":0.782866224577412,"d":"0.78"},{"v":0.867561412881749,"d":"0.87"},{"v":0.0846951883043373,"d":"0.08"}]
["cg13512268","HOXA5",7,27183973,{"v":6.5971396542137e-06,"d":"6.60E-06"},0.410742627113955,{"v":0.880683763740399,"d":"0.88"},{"v":0.82550865687655,"d":"0.83"},{"v":-0.0551751068638495,"d":"-0.06"}]
["cg23936031","HOXA5",7,27183133,{"v":8.67905802591182e-06,"d":"8.68E-06"},0.45237830469513,{"v":0.784793706296721,"d":"0.78"},{"v":0.680664753149131,"d":"0.68"},{"v":-0.104128953147591,"d":"-0.10"}]
["cg09420907",null,12,4273763,{"v":1.00123695624311E-5,"d":"1.00E-05"},0.45237830469513,{"v":0.242366826160993,"d":"0.24"},{"v":0.274241121134947,"d":"0.27"},{"v":0.0318742949739538,"d":"0.03"}]
["cg01905046","TGOLN2",2,85554079,{"v":1.08263016462657e-05,"d":"1.08E-05"},0.45237830469513,{"v":0.142022345219983,"d":"0.14"},{"v":0.283491430724338,"d":"0.28"},{"v":0.141469085504356,"d":"0.14"}]
["cg23454797","HOXA5",7,27183990,{"v":1.43960741084057e-05,"d":"1.44E-05"},0.45237830469513,{"v":0.865647397133257,"d":"0.87"},{"v":0.79885453233713,"d":"0.80"},{"v":-0.066792864796127,"d":"-0.07"}]
["cg08397993","NCRNA00171",6,29981250,{"v":1.66780543866253e-05,"d":"1.67E-05"},0.45237830469513,{"v":0.28951931932148,"d":"0.29"},{"v":0.426593756265681,"d":"0.43"},{"v":0.137074436944201,"d":"0.14"}]
["cg16474696","MRI1;MRI1",19,13875014,{"v":1.89865830646627e-05,"d":"1.90E-05"},0.45237830469513,{"v":0.497353455594542,"d":"0.50"},{"v":0.174224002553426,"d":"0.17"},{"v":-0.323129453041116,"d":"-0.32"}]
["cg01370449","HOXA5",7,27183369,{"v":1.92897341751134e-05,"d":"1.93E-05"},0.45237830469513,{"v":0.781988480009998,"d":"0.78"},{"v":0.701780356815722,"d":"0.70"},{"v":-0.0802081231942755,"d":"-0.08"}]
["cg17432857","HOXA5",7,27184438,{"v":2.10790900544713e-05,"d":"2.11E-05"},0.45237830469513,{"v":0.782321308912851,"d":"0.78"},{"v":0.686379626359626,"d":"0.69"},{"v":-0.0959416825532244,"d":"-0.10"}]
["cg10428938","ARPC1B",7,98990837,{"v":2.11155264488407e-05,"d":"2.11E-05"},0.45237830469513,{"v":0.396369481203259,"d":"0.40"},{"v":0.329799704165986,"d":"0.33"},{"v":-0.066569777037273,"d":"-0.07"}]
["cg27386529","SCAP",3,47517807,{"v":2.15353205107697e-05,"d":"2.15E-05"},0.45237830469513,{"v":0.447251199154713,"d":"0.45"},{"v":0.504702122573738,"d":"0.50"},{"v":0.057450923419025,"d":"0.06"}]
["cg15358701",null,1,161410459,{"v":2.19031499239354e-05,"d":"2.19E-05"},0.45237830469513,{"v":0.14791250457267,"d":"0.15"},{"v":0.11125973968359,"d":"0.11"},{"v":-0.0366527648890806,"d":"-0.04"}]
["cg05076221","HOXA5",7,27182637,{"v":2.25624179576449e-05,"d":"2.26E-05"},0.45237830469513,{"v":0.668046422663196,"d":"0.67"},{"v":0.555359503186462,"d":"0.56"},{"v":-0.112686919476734,"d":"-0.11"}]
["cg09715059",null,6,32223336,{"v":2.32701710206629e-05,"d":"2.33E-05"},0.45237830469513,{"v":0.389598769447631,"d":"0.39"},{"v":0.508992252456769,"d":"0.51"},{"v":0.119393483009138,"d":"0.12"}]
["cg14130272","BAT1;SNORD84;BAT1",6,31509427,{"v":2.36345979261473e-05,"d":"2.36E-05"},0.45237830469513,{"v":0.21170928082564,"d":"0.21"},{"v":0.157564756654309,"d":"0.16"},{"v":-0.0541445241713306,"d":"-0.05"}]
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["cg20825110",null,1,33854504,{"v":2.48479934207404e-05,"d":"2.48E-05"},0.45237830469513,{"v":0.735666517424003,"d":"0.74"},{"v":0.759779362404881,"d":"0.76"},{"v":0.0241128449808774,"d":"0.02"}]
["cg25755428","MRI1;MRI1",19,13875111,{"v":2.49115569613564e-05,"d":"2.49E-05"},0.45237830469513,{"v":0.399196943012737,"d":"0.40"},{"v":0.120222052540094,"d":"0.12"},{"v":-0.278974890472644,"d":"-0.28"}]
["cg14058329","HOXA5",7,27183946,{"v":2.9897369715763e-05,"d":"2.99E-05"},0.462663306083377,{"v":0.897875069652031,"d":"0.90"},{"v":0.839469953720972,"d":"0.84"},{"v":-0.0584051159310587,"d":"-0.06"}]
["cg11235787","MIR195",17,6920975,{"v":3.21257810504055e-05,"d":"3.21E-05"},0.462663306083377,{"v":0.837412067320155,"d":"0.84"},{"v":0.794518543959956,"d":"0.79"},{"v":-0.0428935233601987,"d":"-0.04"}]
["cg15617019","MYO1B;MYO1B;MYO1B",2,192110957,{"v":3.31356918942783e-05,"d":"3.31E-05"},0.462663306083377,{"v":0.0833315358032679,"d":"0.08"},{"v":0.0691447533720925,"d":"0.07"},{"v":-0.0141867824311754,"d":"-0.01"}]
["cg12646786",null,1,178986264,{"v":3.35024393762163e-05,"d":"3.35E-05"},0.462663306083377,{"v":0.256185231469604,"d":"0.26"},{"v":0.3010468700604,"d":"0.30"},{"v":0.0448616385907954,"d":"0.04"}]
["cg25215230",null,4,15679598,{"v":3.39150967433379e-05,"d":"3.39E-05"},0.462663306083377,{"v":0.825605510959573,"d":"0.83"},{"v":0.761464868986143,"d":"0.76"},{"v":-0.0641406419734307,"d":"-0.06"}]
["cg09549073","HOXA5;HOXA5",7,27183274,{"v":3.42499609150353e-05,"d":"3.42E-05"},0.462663306083377,{"v":0.758113244051209,"d":"0.76"},{"v":0.657142731665939,"d":"0.66"},{"v":-0.10097051238527,"d":"-0.10"}]
["cg19086603","F7;F7",13,113773158,{"v":3.5204244265223e-05,"d":"3.52E-05"},0.462663306083377,{"v":0.846099503351853,"d":"0.85"},{"v":0.499041875381117,"d":"0.50"},{"v":-0.347057627970736,"d":"-0.35"}]
["cg08780711",null,17,6560593,{"v":3.58240624492232e-05,"d":"3.58E-05"},0.462663306083377,{"v":0.112065304307224,"d":"0.11"},{"v":0.137391397059065,"d":"0.14"},{"v":0.0253260927518406,"d":"0.03"}]
["cg17569124","HOXA5",7,27183643,{"v":3.65592194173018e-05,"d":"3.66E-05"},0.462663306083377,{"v":0.72041443072704,"d":"0.72"},{"v":0.582721707865046,"d":"0.58"},{"v":-0.137692722861994,"d":"-0.14"}]
["cg00430613",null,17,406426,{"v":3.76445203834914e-05,"d":"3.76E-05"},0.462663306083377,{"v":0.81178856036625,"d":"0.81"},{"v":0.541240198813607,"d":"0.54"},{"v":-0.270548361552643,"d":"-0.27"}]
["cg23072383","SLC35E4",22,31031044,{"v":3.86327764700166e-05,"d":"3.86E-05"},0.462663306083377,{"v":0.14931124451845,"d":"0.15"},{"v":0.189231607821333,"d":"0.19"},{"v":0.0399203633028833,"d":"0.04"}]
["cg02916332","HOXA5",7,27183591,{"v":3.96151530998113e-05,"d":"3.96E-05"},0.462663306083377,{"v":0.758225838035443,"d":"0.76"},{"v":0.658768370363647,"d":"0.66"},{"v":-0.0994574676717962,"d":"-0.10"}]
["cg24524379","LRRC2;LRRC2",3,46600244,{"v":4.03026983039689e-05,"d":"4.03E-05"},0.462663306083377,{"v":0.279055949672116,"d":"0.28"},{"v":0.391683103914825,"d":"0.39"},{"v":0.11262715424271,"d":"0.11"}]
["cg25307665","HOXA5",7,27183694,{"v":4.0340057663439e-05,"d":"4.03E-05"},0.462663306083377,{"v":0.684743196508821,"d":"0.68"},{"v":0.526852199602841,"d":"0.53"},{"v":-0.157890996905979,"d":"-0.16"}]
["cg04985482","MICA",6,31382065,{"v":4.21675977199907e-05,"d":"4.22E-05"},0.471222904520896,{"v":0.873183999978685,"d":"0.87"},{"v":0.781047018871214,"d":"0.78"},{"v":-0.0921369811074704,"d":"-0.09"}]
["cg13730736","KCNT1",9,138653071,{"v":4.42948642657856E-5,"d":"4.43E-05"},0.482620230465901,{"v":0.480766769411336,"d":"0.48"},{"v":0.525652816746773,"d":"0.53"},{"v":0.0448860473354368,"d":"0.04"}]
["cg24727561","UBD",6,29524112,{"v":4.54314173644133E-5,"d":"4.54E-05"},0.482930426166962,{"v":0.862051421929052,"d":"0.86"},{"v":0.834309082293187,"d":"0.83"},{"v":-0.0277423396358651,"d":"-0.03"}]
["cg09861346","GPRIN1",5,176037510,{"v":4.89573787170585e-05,"d":"4.90E-05"},0.486208136611596,{"v":0.214249551537454,"d":"0.21"},{"v":0.169101075139383,"d":"0.17"},{"v":-0.0451484763980707,"d":"-0.05"}]
["cg18825531",null,11,62321136,{"v":4.97959526388836e-05,"d":"4.98E-05"},0.486208136611596,{"v":0.259037069821816,"d":"0.26"},{"v":0.347872660048166,"d":"0.35"},{"v":0.0888355902263501,"d":"0.09"}]
["cg02527881","PTH1R",3,46936655,{"v":5.08621428425016e-05,"d":"5.09E-05"},0.486208136611596,{"v":0.560734162161149,"d":"0.56"},{"v":0.729402296597517,"d":"0.73"},{"v":0.168668134436368,"d":"0.17"}]
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["cg22024931","SMN1;SMN2;SMN2;SMN2;SMN1;SMN2",5,69371421,{"v":5.20980819544573e-05,"d":"5.21E-05"},0.486208136611596,{"v":0.788657568736731,"d":"0.79"},{"v":0.54552276262917,"d":"0.55"},{"v":-0.243134806107561,"d":"-0.24"}]
["cg27196467","KCNIP4;KCNIP4;KCNIP4;KCNIP4",4,21305490,{"v":5.24333905139563E-5,"d":"5.24E-05"},0.486208136611596,{"v":0.319537438452557,"d":"0.32"},{"v":0.424869674999908,"d":"0.42"},{"v":0.105332236547351,"d":"0.11"}]
["cg22862634","EML3;MTA2",11,62369728,{"v":5.64693597013882E-5,"d":"5.65E-05"},0.487327037564496,{"v":0.301823308619644,"d":"0.30"},{"v":0.201866081758223,"d":"0.20"},{"v":-0.0999572268614217,"d":"-0.10"}]
["cg07307142","HSD17B2",16,82071433,{"v":5.84847534158354E-5,"d":"5.85E-05"},0.487327037564496,{"v":0.652792701403346,"d":"0.65"},{"v":0.540343744608665,"d":"0.54"},{"v":-0.11244895679468,"d":"-0.11"}]
["cg02005600","HOXA5",7,27183686,{"v":6.14998582407123e-05,"d":"6.15E-05"},0.487327037564496,{"v":0.783767849150154,"d":"0.78"},{"v":0.677110267801466,"d":"0.68"},{"v":-0.106657581348689,"d":"-0.11"}]
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["cg12337005",null,5,139135602,{"v":6.27109030527981e-05,"d":"6.27E-05"},0.487327037564496,{"v":0.279240462482989,"d":"0.28"},{"v":0.164045057631294,"d":"0.16"},{"v":-0.115195404851695,"d":"-0.12"}]
["cg21852792",null,2,71678463,{"v":6.29869253438648e-05,"d":"6.30E-05"},0.487327037564496,{"v":0.423953544684551,"d":"0.42"},{"v":0.465123144438613,"d":"0.47"},{"v":0.0411695997540618,"d":"0.04"}]
["cg03480206",null,14,24914181,{"v":6.31237738967677e-05,"d":"6.31E-05"},0.487327037564496,{"v":0.842409545602965,"d":"0.84"},{"v":0.857653070473151,"d":"0.86"},{"v":0.0152435248701853,"d":"0.02"}]
["cg11862551",null,6,29817963,{"v":6.31362586895389e-05,"d":"6.31E-05"},0.487327037564496,{"v":0.254910186017365,"d":"0.25"},{"v":0.156051753683158,"d":"0.16"},{"v":-0.0988584323342071,"d":"-0.10"}]
["cg26545143","GADL1",3,30936239,{"v":6.39605705351909E-5,"d":"6.40E-05"},0.487327037564496,{"v":0.100074112543206,"d":"0.10"},{"v":0.114682667805623,"d":"0.11"},{"v":0.0146085552624177,"d":"0.01"}]
["cg23321397",null,6,32223430,{"v":6.74696885389167e-05,"d":"6.75E-05"},0.487327037564496,{"v":0.479627855902622,"d":"0.48"},{"v":0.589397850761155,"d":"0.59"},{"v":0.109769994858533,"d":"0.11"}]
["cg01514490",null,10,7455338,{"v":6.86807503177373e-05,"d":"6.87E-05"},0.487327037564496,{"v":0.555783798145253,"d":"0.56"},{"v":0.611064860695196,"d":"0.61"},{"v":0.0552810625499426,"d":"0.06"}]
["cg24941931","C19orf44;CALR3",19,16607335,{"v":6.94842642339889e-05,"d":"6.95E-05"},0.487327037564496,{"v":0.104568522786405,"d":"0.10"},{"v":0.0909430173441001,"d":"0.09"},{"v":-0.0136255054423048,"d":"-0.01"}]
["cg12128839","HOXA5",7,27183436,{"v":6.99774317864388e-05,"d":"7.00E-05"},0.487327037564496,{"v":0.712317196890992,"d":"0.71"},{"v":0.582548365614652,"d":"0.58"},{"v":-0.12976883127634,"d":"-0.13"}]
["cg12176783","TCEA2;TCEA2",20,62694000,{"v":7.11490895042005e-05,"d":"7.11E-05"},0.487327037564496,{"v":0.71570452055991,"d":"0.72"},{"v":0.656681862629168,"d":"0.66"},{"v":-0.059022657930742,"d":"-0.06"}]
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["cg18965391","FLJ40434",1,53905819,0.0499876988032533,0.936779034772014,{"v":0.750648053114119,"d":"0.75"},{"v":0.762168892912869,"d":"0.76"},{"v":0.0115208397987498,"d":"0.01"}]
["cg15715881","NOTCH2NL;NOTCH2NL",1,145209236,0.0499894273152834,0.936779034772014,{"v":0.0492295233546156,"d":"0.05"},{"v":0.0481576067032158,"d":"0.05"},{"v":-1.07191665139988E-3,"d":"-0.00"}]
["cg00153934","LCA5;LCA5",6,80247286,0.0499920894160382,0.936779034772014,{"v":0.0819027798814093,"d":"0.08"},{"v":0.0740596839132696,"d":"0.07"},{"v":-0.00784309596813976,"d":"-0.01"}]
["cg14649589",null,8,56578622,0.049994032093665,0.936779034772014,{"v":0.807216164250395,"d":"0.81"},{"v":0.819957287929455,"d":"0.82"},{"v":0.0127411236790607,"d":"0.01"}]
["cg02834871","SCAMP3;FAM189B;FAM189B;SCAMP3",1,155226127,0.0499969591063965,0.936779034772014,{"v":0.861068390656682,"d":"0.86"},{"v":0.866348665271804,"d":"0.87"},{"v":0.00528027461512248,"d":"0.01"}]
["cg20842326","PTPRN2;PTPRN2;PTPRN2",7,157476887,0.0499973929014815,0.936779034772014,{"v":0.214010813980972,"d":"0.21"},{"v":0.209719005159579,"d":"0.21"},{"v":-0.00429180882139249,"d":"-0.00"}]
[]
["Table 4. Probes attaining an uncorrected p-value of ≤ 0.05 in the comparison of affected individuals carrying the linked haplotype (ALH) and married in controls (MI), ranked by p-value. Where a probe maps to multiple overlapping transcripts these are indicated separated by a semicolon. Adjusted p-values were calculated using Benjamini-Hochberg's False Disovery Rate procedure. aGRCh37/hg16.  bAdjusted p-values were calculated using Benjamini-Hochberg's False Disovery Rate procedure. cALH β mean – MI β mean."]

{"sheet":"SOM Table 5","index":4,"n_rows":20602,"n_cols":9,"rows_kept":4500,"cut":true,"merged":[[20601,0,20601,8]],"bounds":{"rows_first":2000,"rows_last":500,"rows_between":2000,"halvings":0}}
["Probe ID","Gene symbol","Chr.","Coordinatea","p-value","Adjusted p-valueb","MI β (mean)","ULH β (mean)","β differencec"]
["cg17192377","HDHD2",18,44677553,{"v":1.32573008981044e-06,"d":"1.33E-06"},0.408526397955015,{"v":0.42059158496617,"d":"0.42"},{"v":0.503904928874355,"d":"0.50"},{"v":0.0833133439081845,"d":"0.08"}]
["cg00703898",null,16,34299638,{"v":2.6589792200031E-6,"d":"2.66E-06"},0.408526397955015,{"v":0.677709700023048,"d":"0.68"},{"v":0.619782748053267,"d":"0.62"},{"v":-0.0579269519697807,"d":"-0.06"}]
["cg14130272","BAT1;SNORD84;BAT1",6,31509427,{"v":3.49947665350241E-6,"d":"3.50E-06"},0.408526397955015,{"v":0.21170928082564,"d":"0.21"},{"v":0.143909449285513,"d":"0.14"},{"v":-0.0677998315401274,"d":"-0.07"}]
["cg05985560",null,4,1563672,{"v":6.44344214376334e-06,"d":"6.44E-06"},0.408526397955015,{"v":0.947727910679394,"d":"0.95"},{"v":0.935259131441771,"d":"0.94"},{"v":-0.0124687792376224,"d":"-0.01"}]
["cg12251573","AHRR",5,421644,{"v":6.88400029574712e-06,"d":"6.88E-06"},0.408526397955015,{"v":0.698626096924077,"d":"0.70"},{"v":0.842936263183464,"d":"0.84"},{"v":0.144310166259387,"d":"0.14"}]
["cg03832522",null,2,218898668,{"v":8.79730484209311e-06,"d":"8.80E-06"},0.408526397955015,{"v":0.28140047435551,"d":"0.28"},{"v":0.342160713983777,"d":"0.34"},{"v":0.0607602396282678,"d":"0.06"}]
["cg04985482","MICA",6,31382065,{"v":8.81711258071393e-06,"d":"8.82E-06"},0.408526397955015,{"v":0.873183999978685,"d":"0.87"},{"v":0.763259112163387,"d":"0.76"},{"v":-0.109924887815298,"d":"-0.11"}]
["cg09420907",null,12,4273763,{"v":9.08130756181456e-06,"d":"9.08E-06"},0.408526397955015,{"v":0.242366826160993,"d":"0.24"},{"v":0.273306935859019,"d":"0.27"},{"v":0.0309401096980252,"d":"0.03"}]
["cg22708112","GCOM1;GCOM1;GCOM1;GCOM1",15,57883392,{"v":1.02454790451453e-05,"d":"1.02E-05"},0.408526397955015,{"v":0.820541150626641,"d":"0.82"},{"v":0.734241085735744,"d":"0.73"},{"v":-0.0863000648908978,"d":"-0.09"}]
["cg10294474",null,16,49090004,{"v":1.03126263448977e-05,"d":"1.03E-05"},0.408526397955015,{"v":0.696230395997395,"d":"0.70"},{"v":0.766594426164328,"d":"0.77"},{"v":0.0703640301669333,"d":"0.07"}]
["cg08513547","LOC134466",5,150323558,{"v":1.15266292422415e-05,"d":"1.15E-05"},0.408526397955015,{"v":0.786134959711682,"d":"0.79"},{"v":0.745669170239554,"d":"0.75"},{"v":-0.0404657894721284,"d":"-0.04"}]
["cg01323381","HOXA5",7,27184264,{"v":1.1535162243743e-05,"d":"1.15E-05"},0.408526397955015,{"v":0.829710886828012,"d":"0.83"},{"v":0.771253672037839,"d":"0.77"},{"v":-0.058457214790173,"d":"-0.06"}]
["cg20254225","CYP1B1",2,38301438,{"v":1.29338715400333E-5,"d":"1.29E-05"},0.408526397955015,{"v":0.197027292994326,"d":"0.20"},{"v":0.168692916345882,"d":"0.17"},{"v":-0.0283343766484433,"d":"-0.03"}]
["cg12858231","FANCI;FANCI",15,89846095,{"v":1.3123087412081e-05,"d":"1.31E-05"},0.408526397955015,{"v":0.78112434212209,"d":"0.78"},{"v":0.813758055721553,"d":"0.81"},{"v":0.0326337135994621,"d":"0.03"}]
["cg09755872",null,7,23245557,{"v":1.46481975717027e-05,"d":"1.46E-05"},0.416242105966337,{"v":0.439485428501205,"d":"0.44"},{"v":0.495048612947067,"d":"0.50"},{"v":0.0555631844458616,"d":"0.06"}]
["cg17448192","ST6GAL1;ST6GAL1",3,186718821,{"v":1.52810731267399e-05,"d":"1.53E-05"},0.416242105966337,{"v":0.580449900392568,"d":"0.58"},{"v":0.634625068093105,"d":"0.63"},{"v":0.0541751677005368,"d":"0.05"}]
["cg23936031","HOXA5",7,27183133,{"v":1.94661312331613E-5,"d":"1.95E-05"},0.499048626158385,{"v":0.784793706296721,"d":"0.78"},{"v":0.68131163977451,"d":"0.68"},{"v":-0.103482066522211,"d":"-0.10"}]
["cg23083776",null,6,32381485,{"v":2.20780336251066E-5,"d":"2.21E-05"},0.534564389147893,{"v":0.145003592443133,"d":"0.15"},{"v":0.122934271428589,"d":"0.12"},{"v":-0.0220693210145442,"d":"-0.02"}]
["cg17432857","HOXA5",7,27184438,{"v":2.64754289846477e-05,"d":"2.65E-05"},0.562761370631945,{"v":0.782321308912851,"d":"0.78"},{"v":0.693301867986448,"d":"0.69"},{"v":-0.0890194409264029,"d":"-0.09"}]
["cg12176783","TCEA2;TCEA2",20,62694000,{"v":2.66714776882039e-05,"d":"2.67E-05"},0.562761370631945,{"v":0.71570452055991,"d":"0.72"},{"v":0.649957760635661,"d":"0.65"},{"v":-0.0657467599242481,"d":"-0.07"}]
["cg12772613",null,10,2267540,{"v":2.71163627218972e-05,"d":"2.71E-05"},0.562761370631945,{"v":0.885464963787054,"d":"0.89"},{"v":0.870501836896944,"d":"0.87"},{"v":-0.0149631268901095,"d":"-0.01"}]
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["cg14058329","HOXA5",7,27183946,{"v":3.7323484785341e-05,"d":"3.73E-05"},0.665743404288236,{"v":0.897875069652031,"d":"0.90"},{"v":0.836400102330872,"d":"0.84"},{"v":-0.0614749673211591,"d":"-0.06"}]
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["cg23940612",null,2,218898788,{"v":4.14930842842212e-05,"d":"4.15E-05"},0.665743404288236,{"v":0.228636952651443,"d":"0.23"},{"v":0.269485972458069,"d":"0.27"},{"v":0.0408490198066256,"d":"0.04"}]
["cg11103845","PBX2",6,32157230,{"v":4.33373889130834e-05,"d":"4.33E-05"},0.665743404288236,{"v":0.175678496275575,"d":"0.18"},{"v":0.201723588194575,"d":"0.20"},{"v":0.0260450919190001,"d":"0.03"}]
["cg25407410","LOC285740",6,143891975,{"v":4.40732456764482e-05,"d":"4.41E-05"},0.665743404288236,{"v":0.819612361496841,"d":"0.82"},{"v":0.701533557585266,"d":"0.70"},{"v":-0.118078803911575,"d":"-0.12"}]
["cg19108771","TNXB",6,32076337,{"v":4.5058656777625e-05,"d":"4.51E-05"},0.665743404288236,{"v":0.501763480182025,"d":"0.50"},{"v":0.574976295299099,"d":"0.57"},{"v":0.0732128151170739,"d":"0.07"}]
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["cg25307665","HOXA5",7,27183694,{"v":5.11814420023919e-05,"d":"5.12E-05"},0.680667939832026,{"v":0.684743196508821,"d":"0.68"},{"v":0.549649923905795,"d":"0.55"},{"v":-0.135093272603025,"d":"-0.14"}]
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["cg21695935","SPATA22;SPATA22;SPATA22;SPATA22;SPATA22;SPATA22",17,3375223,{"v":5.16685601513273e-05,"d":"5.17E-05"},0.680667939832026,{"v":0.864912405479731,"d":"0.86"},{"v":0.706943500516891,"d":"0.71"},{"v":-0.15796890496284,"d":"-0.16"}]
["cg20296327",null,2,490186,{"v":5.31009234309388e-05,"d":"5.31E-05"},0.680667939832026,{"v":0.756795510619769,"d":"0.76"},{"v":0.78831837962444,"d":"0.79"},{"v":0.0315228690046716,"d":"0.03"}]
["cg14719055","RBBP7","X",16889683,{"v":6.18903048895381e-05,"d":"6.19E-05"},0.73798067094139,{"v":0.551527765754561,"d":"0.55"},{"v":0.600878035474955,"d":"0.60"},{"v":0.0493502697203941,"d":"0.05"}]
["cg12386194","SENP7;SENP7",3,101231763,{"v":6.19845000453833e-05,"d":"6.20E-05"},0.73798067094139,{"v":0.0567639619857378,"d":"0.06"},{"v":0.0682755677439632,"d":"0.07"},{"v":0.0115116057582254,"d":"0.01"}]
["cg24524379","LRRC2;LRRC2",3,46600244,{"v":6.74557458903142e-05,"d":"6.75E-05"},0.73798067094139,{"v":0.279055949672116,"d":"0.28"},{"v":0.368530602085337,"d":"0.37"},{"v":0.0894746524132211,"d":"0.09"}]
["cg10368935","SLC39A12;SLC39A12",10,18240316,{"v":6.84321020723737e-05,"d":"6.84E-05"},0.73798067094139,{"v":0.529711950746179,"d":"0.53"},{"v":0.593591946944965,"d":"0.59"},{"v":0.0638799961987859,"d":"0.06"}]
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["cg08929903","FAM170A;FAM170A;FAM170A;FAM170A",5,118965347,{"v":7.17412745177544e-05,"d":"7.17E-05"},0.73798067094139,{"v":0.867837704957146,"d":"0.87"},{"v":0.885880182792518,"d":"0.89"},{"v":0.0180424778353723,"d":"0.02"}]
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[]
["Table 5. Probes attaining an uncorrected p-value of ≤ 0.05 in the comparison of unaffected individuals carrying the linked haplotype (ULH) and married in controls (MI), ranked by p-value. Where a probe maps to multiple overlapping transcripts these are indicated separated by a semicolon. Adjusted p-values were calculated using Benjamini-Hochberg's False Disovery Rate procedure. aGRCh37/hg16.  bAdjusted p-values were calculated using Benjamini-Hochberg's False Disovery Rate procedure. cULH β mean – MI β mean."]

{"sheet":"SOM Table 6","index":5,"n_rows":16758,"n_cols":9,"rows_kept":4500,"cut":true,"merged":[[16757,0,16757,8]],"bounds":{"rows_first":2000,"rows_last":500,"rows_between":2000,"halvings":0}}
["Probe ID","Gene symbol","Chr.","Coordinatea","p-value","Adjusted p-valueb","ULH β (mean)","ALH β (mean)","β differencec"]
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["ch.17.1317324F",null,17,48294274,{"v":4.48070263009619e-05,"d":"4.48E-05"},0.999995930989466,{"v":0.0938629639479825,"d":"0.09"},{"v":0.108770602963358,"d":"0.11"},{"v":0.0149076390153754,"d":"0.01"}]
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[]
["Table 6. Probes attaining an uncorrected p-value of ≤ 0.05 in the comparison of affected individuals carrying the linked haplotype (ALH) and unaffected carriers of the linked haplotype (ULH), ranked by p-value. Where a probe maps to multiple overlapping transcripts these are indicated separated by a semicolon. Adjusted p-values were calculated using Benjamini-Hochberg's False Disovery Rate procedure. aGRCh37/hg16.  bAdjusted p-values were calculated using Benjamini-Hochberg's False Disovery Rate procedure. cALH β mean – ULH β mean."]

{"sheet":"SOM Table 7","index":6,"n_rows":153,"n_cols":7,"rows_kept":153,"merged":[[152,0,152,6]]}
["Gene Symbol","p-value","Chr.","Start coordinatea","Length","No. probes","Directionb"]
["HOXA5",3.64749121269697e-62,7,27183659,829,29,"Down"]
["RNF39",3.44925559494644e-32,6,30038897,847,24,"Up"]
["-",5.18907321288672e-12,6,32221987,2554,6,"Up"]
["C8orf31",1.24473170770667e-10,8,144120291,494,7,"Down"]
["TNXB",7.70605366024539E-10,6,32075839,818,5,"Up"]
["KRT3",8.07479153952729e-10,12,53183861,369,4,"Up"]
["-",9.13110322783069e-10,17,406344,164,3,"Down"]
["GADL1",1.47428858554274e-08,3,30936238,18,3,"Up"]
["LOC149837",1.6500022205578e-08,20,5484699,890,10,"Up"]
["BAT1; SNORD84",2.77042964419871e-08,6,31509237,305,4,"Down"]
["FRMD4A",3.02613115980379e-08,10,14051191,1282,6,"Down"]
["FLJ42875; PRDM16",4.77536286810399E-8,1,2984140,213,4,"Down"]
["DDR1",1.66293253513877e-07,6,30859410,1335,5,"Up"]
["ZFAND2A",1.78864744474398e-07,7,1198811,230,3,"Up"]
["TNXB",1.78864744474398e-07,6,32013855,1264,6,"Up"]
["LRRC2",2.02629528590636e-07,3,46607910,344,5,"Up"]
["GPR133",2.10010564467725E-7,12,131616599,938,3,"Down"]
["TNFAIP2",2.57612875513862E-7,14,103593425,173,3,"Down"]
["-",4.45303732047849e-07,2,242712042,3797,3,"Down"]
["-",5.37016077499632E-7,6,25026475,2350,3,"Down"]
["-",6.52869579585342e-07,12,115131157,3915,6,"Down"]
["-",6.84137530038453e-07,6,33870360,4442,8,"Down"]
["NCRNA00171",7.45333934235879e-07,6,29980805,1051,3,"Up"]
["-",7.45333934235879e-07,14,106327859,3541,4,"Down"]
["PCGF3",7.93273474872194e-07,4,717500,4939,5,"Up"]
["RNU5E; RNU5D; CKMT2",7.93273474872194e-07,5,80528622,958,4,"Down"]
["CDH13",1.07023152930431E-6,16,83170623,1121,3,"Up"]
["-",1.07023152930431E-6,10,125032659,3270,4,"Up"]
["-",1.7885745083323e-06,10,3281120,2641,4,"Up"]
["MIR574; FAM114A1",1.92714699440975e-06,4,38869629,156,3,"Down"]
["-",1.95152031605099E-6,2,242903627,2277,3,"Down"]
["HSPB6",3.03365235769353E-6,19,36246326,151,4,"Down"]
["-",3.29867116512512e-06,5,1866867,2601,5,"Up"]
["KLF11",3.41496057609241e-06,2,10183088,54,3,"Down"]
["LOC339290; C18orf18",4.71478253627556e-06,18,5238564,288,3,"Down"]
["SH3PXD2B",4.71478253627556e-06,5,171881532,44,4,"Up"]
["-",4.78077397103043e-06,10,45359449,434,3,"Up"]
["LOC387647",5.75259328070401e-06,10,29698453,18,3,"Down"]
["HTR2A",5.83943743057519e-06,13,47472142,315,5,"Down"]
["UBD",6.80675478203353e-06,6,29523133,1827,3,"Down"]
["-",9.45285761294015e-06,1,2837694,2347,3,"Down"]
["-",1.0341624270656E-5,10,45360718,324,3,"Down"]
["HLA-DQA2",1.11804652753807e-05,6,32711172,1318,3,"Up"]
["CATSPER4",1.35088481850472E-5,1,26527425,948,3,"Up"]
["TRAPPC9",1.36688057725936E-5,8,141359530,288,4,"Up"]
["-",1.46775101703345e-05,11,2307251,2969,4,"Up"]
["TNXB",1.52917988982122e-05,6,32063315,370,5,"Up"]
["ZNF833",1.56582478492949e-05,19,11785047,219,4,"Up"]
["FLJ12825",1.74343056061907E-5,12,54454019,384,4,"Down"]
["RADIL",1.75762356835143e-05,7,4858386,1905,3,"Up"]
["RFPL3",1.75762356835143e-05,22,32750641,480,3,"Down"]
["TBCD",1.98274669532874e-05,17,80875294,1523,4,"Up"]
["CYP2W1",2.05292731960074e-05,7,1022774,134,3,"Down"]
["-",2.05292731960074e-05,6,166258901,3174,5,"Up"]
["-",2.05292731960074e-05,2,172974573,324,3,"Down"]
["-",2.10079035836026e-05,8,689746,475,3,"Down"]
["WRB",2.10079035836026e-05,21,40759430,408,4,"Up"]
["-",2.39597209305687E-5,2,8682834,2403,3,"Up"]
["EHMT2",2.57411249512107e-05,6,31859360,1797,3,"Up"]
["-",2.79547005326321E-5,"X",73756616,219,3,"Down"]
["PNLDC1",2.9279896078783e-05,6,160239555,4002,4,"Up"]
["BAT3",3.59329018223174e-05,6,31615245,2292,4,"Up"]
["-",4.03945827363617e-05,5,1961200,2465,3,"Down"]
["SORD",4.11888576069125E-5,15,45314852,154,3,"Up"]
["BDKRB2",4.41695465113291e-05,14,96670526,216,3,"Up"]
["-",4.61920869285689e-05,7,187092,409,3,"Down"]
["-",4.61920869285689e-05,6,29932586,2496,3,"Up"]
["-",4.9567655070732e-05,15,62516120,324,3,"Up"]
["KCTD12",4.9567655070732e-05,13,77461305,126,3,"Up"]
["REEP4",5.12604068265653e-05,8,21995391,2091,3,"Up"]
["RPTOR",5.42866573514595e-05,17,78865119,398,4,"Up"]
["PDE4D",5.63796429491135e-05,5,59189646,281,4,"Down"]
["ZNF19",5.96079375070862e-05,16,71523367,216,3,"Up"]
["CDKL5",6.19018525451795e-05,"X",18443697,86,3,"Down"]
["-",6.19018525451795e-05,6,31461739,164,3,"Down"]
["-",6.27704118215249e-05,12,7069451,2392,3,"Up"]
["TNXB",6.34835749836849e-05,6,32048334,2022,4,"Up"]
["DSCAML1",7.10280068238414e-05,11,117668026,23,3,"Up"]
["HLA-DRB1",7.48031560137085e-05,6,32551938,246,4,"Down"]
["-",8.40859082221047e-05,10,130278533,2285,3,"Up"]
["-",8.78059405545692e-05,12,133407909,3657,3,"Up"]
["C19orf30",8.784421978285e-05,19,4768701,890,3,"Down"]
["CDSN; PSORS1C1",9.30043882767624e-05,6,31087968,574,4,"Down"]
["-",9.51405902755801e-05,14,70689343,2306,3,"Up"]
["SRPK3",1.05458476343786E-4,"X",153046431,100,3,"Up"]
["SFRP2",1.05458476343786E-4,4,154710402,54,3,"Down"]
["-",1.19939233598973E-4,1,946841,474,4,"Up"]
["PRSS22",1.20031983852282E-4,16,2908829,168,3,"Down"]
["ADCY4",0.000130657304891172,14,24801047,288,3,"Down"]
["LOC284798",1.35121114465868E-4,20,25129493,76,4,"Up"]
["RPS6KA2",1.35121114465868E-4,6,166876045,1136,3,"Down"]
["ADPRHL1",1.45130456620077E-4,13,114103032,1126,4,"Down"]
["-",0.000149782063389245,4,8701168,2478,3,"Down"]
["VARS2; GTF2H4",1.52794880466992E-4,6,30881616,75,3,"Down"]
["HLA-DQB1",1.52794880466992E-4,6,32632859,211,3,"Down"]
["POU2AF1",1.52794880466992E-4,11,111250323,216,3,"Down"]
["BEGAIN",1.71154292819778E-4,14,101029055,1686,3,"Down"]
["STK32C",0.000176464615929314,10,134043054,1686,4,"Up"]
["PIWIL2",0.000178069379099168,8,22132877,131,4,"Down"]
["NUDT12",0.000178069379099168,5,102898223,495,3,"Down"]
["-",0.000178069379099168,12,107296127,2411,3,"Down"]
["-",0.000178069379099168,11,133656355,2869,3,"Up"]
["SIAH3",1.79136117104231E-4,13,46425597,480,4,"Up"]
["-",1.84402737086979E-4,1,147782396,324,3,"Down"]
["-",0.000189996896949757,6,29520851,334,3,"Down"]
["MYT1L",2.02286371312757E-4,2,1858590,1001,3,"Up"]
["PRDM8",2.07905502968116E-4,4,81106657,230,3,"Down"]
["C13orf16",0.000220034049630451,13,111972903,480,4,"Down"]
["-",0.000221289677229547,5,757605,3883,3,"Up"]
["TNFAIP8",0.000221289677229547,5,118603817,184,3,"Up"]
["HLA-DMA",2.30649411371653E-4,6,32917534,1330,3,"Down"]
["MESTIT1; MEST",2.36720906360484E-4,7,130130045,288,6,"Down"]
["TRIM6-TRIM34; TRIM6",2.41103800137131E-4,11,5617165,231,3,"Down"]
["PCDHA7; PCDHA12; PCDHA6; PCDHAC1",0.000249695333011549,5,140306130,179,3,"Down"]
["TNXB",2.55048619603038E-4,6,32036573,890,3,"Down"]
["-",0.00027860297972704,6,26756595,2911,3,"Down"]
["C1orf70",0.000280976296789801,1,1475121,288,3,"Down"]
["CCNA1",0.00028195571844848,13,37004684,126,3,"Up"]
["KCNQ1DN",0.000283985968845158,11,2890620,77,3,"Up"]
["BRSK2",0.000284410361892141,11,1413138,288,3,"Up"]
["HLA-G",2.93843445011475E-4,6,29795386,230,3,"Down"]
["MAML2",0.000306041743683964,11,95975930,1157,3,"Up"]
["KRTAP12-3; C21orf29",3.07018046725517E-4,21,46077690,66,3,"Down"]
["-",3.20415810600942E-4,4,178364101,3496,3,"Up"]
["FOXG1",3.51236508474418E-4,14,29235921,155,3,"Down"]
["HIVEP3",0.000371169493784862,1,42384298,134,3,"Up"]
["SMAD9",0.000379476181276146,13,37452984,1059,3,"Down"]
["FOXK1",0.000416405496772518,7,4760950,2264,3,"Down"]
["HSPC072; LOC100270804",0.000419559330192207,20,18774236,890,10,"Down"]
["SLC17A7",0.000419559330192207,19,49935815,156,3,"Down"]
["ZFYVE28",0.000425895463540546,4,2402938,2189,3,"Down"]
["RGMA",0.000425895463540546,15,93616865,156,3,"Down"]
["GTF2H4",0.000471052738386224,6,30879656,288,3,"Up"]
["TRIM15",0.000473932218365933,6,30139398,338,3,"Down"]
["ANXA5",0.000534598548538045,4,122618144,18,3,"Up"]
["ADAM5P",0.000553708092289525,8,39172074,71,3,"Up"]
["S100A6",0.00056294633291912,1,153508462,129,3,"Up"]
["HOXC4; HOXC5; HOXC6",0.000593938424446194,12,54410547,295,3,"Up"]
["RIC3",6.4552453281632E-4,11,8190759,141,3,"Down"]
["MIR941-1; DNAJC5; MIR941-3; MIR941-2",0.000674431015433709,20,62549296,126,3,"Down"]
["NCRNA00171; ZNRD1",0.000677544096600393,6,30029132,90,3,"Up"]
["-",0.00078590495746797,6,156884560,2295,3,"Up"]
["PTPRN2",0.000848138300079466,7,157754155,1036,3,"Up"]
["PTPRN2",0.000855123409465391,7,157667907,288,6,"Up"]
["NCOR2",0.000907262391978423,12,124907774,1946,3,"Up"]
["C10orf93",0.000907262391978423,10,134750830,2196,3,"Up"]
["-",0.000938758549319932,17,77894573,2712,3,"Down"]
["SEPT9",0.00103371523352762,17,75315427,480,3,"Down"]
["-",0.001121582767214,10,134724917,4150,3,"Down"]
["-",1.48501228597624E-3,11,2285986,3496,3,"Up"]
[]
["SOM Table 7. Differentially methylated regions (DMRs) identified in affected carriers of the linked haplotye (ALH) compared to married in controls (MI), ranked by p-value.  aGRCh37/hg19. bThe direction of change is indicated with respect to the MI group.\n"]

{"sheet":"SOM Table 8","index":7,"n_rows":159,"n_cols":7,"rows_kept":159,"merged":[[158,0,158,6]]}
["Gene Symbol","p-value","Chr.","Start coordinatea","Length","No. probes","Directionb"]
["HOXA5",1.62291191436185E-77,7,27183659,829,29,"Down"]
["RNF39",2.11309912709632e-29,6,30038897,847,22,"Up"]
["TNXB",8.9175621331968e-13,6,32075839,818,6,"Up"]
["-",2.86542475904589e-12,6,32221987,2554,5,"Up"]
["BAT1; SNORD84",1.85272357650443e-11,6,31509237,305,4,"Down"]
["STK32C",3.47170328080545E-11,10,134043054,3398,9,"Up"]
["C8orf31",5.04390682125481e-11,8,144120291,494,7,"Down"]
["-",2.33185161907766e-10,10,125032659,3270,7,"Up"]
["KCNQ1DN",2.57145351694508e-10,11,2890423,274,10,"Up"]
["-",3.37968942242323e-10,17,406344,164,3,"Down"]
["TRAPPC9",1.0613348263182E-8,8,141359530,288,4,"Up"]
["LOC149837",2.37884186381846e-08,20,5484699,890,6,"Up"]
["-",2.99129954295876e-08,6,28956242,639,9,"Down"]
["FRMD4A",3.22714180489018e-08,10,14051191,1282,6,"Down"]
["GPR133",4.5108139929853e-08,12,131616599,938,3,"Down"]
["-",4.5108139929853e-08,14,106327859,3541,4,"Down"]
["TNFAIP2",1.99932581071866e-07,14,103593425,173,3,"Down"]
["NUDT12",2.36988932329925e-07,5,102898223,618,5,"Down"]
["ZFAND2A",3.16663495918617e-07,7,1198811,230,3,"Up"]
["TNXB",3.30457602369671e-07,6,32013855,1264,6,"Up"]
["NCRNA00171",4.27647644044528e-07,6,29980805,1051,3,"Up"]
["FLJ42875; PRDM16",4.27647644044528e-07,1,2984140,213,4,"Down"]
["PCGF3",4.79005892173695e-07,4,717500,4939,5,"Up"]
["RPS6KA2",4.91470174131882e-07,6,166876045,1226,5,"Down"]
["-",6.68881927606453e-07,2,242712042,3797,3,"Down"]
["TNXB",8.78763548113549e-07,6,32063295,390,6,"Up"]
["-",2.10142805367894E-6,6,33870360,4442,8,"Down"]
["SORD",2.55372994266679E-6,15,45314852,154,3,"Up"]
["DDR1",3.92485465473934e-06,6,30859410,1335,6,"Up"]
["-",4.01824505694582e-06,6,29520851,334,3,"Down"]
["HLA-DQA2",4.01824505694582e-06,6,32711172,1318,3,"Up"]
["CDH13",4.01824505694582e-06,16,83170623,1121,3,"Up"]
["-",4.42482803818699E-6,1,2837694,2347,3,"Down"]
["HSPB6",4.42482803818699E-6,19,36246326,151,4,"Down"]
["DSCAML1",4.76492429077284e-06,11,117668026,23,3,"Up"]
["LRRC2",4.82137258939893e-06,3,46607941,313,4,"Up"]
["GALNT2",4.83681955223796e-06,1,230415047,356,4,"Down"]
["-",5.06285951747717e-06,1,946713,602,5,"Up"]
["BRSK2",5.90839230809856e-06,11,1413138,288,3,"Up"]
["-",6.07024290742803e-06,6,25026475,2350,3,"Down"]
["-",7.88248489654163e-06,10,45360718,324,3,"Down"]
["-",8.60165180080774e-06,6,29932586,2496,4,"Up"]
["-",8.60165180080774e-06,8,1365497,324,3,"Down"]
["-",8.60165180080774e-06,6,31461739,196,4,"Down"]
["-",8.87626188006093e-06,2,242903627,2277,3,"Down"]
["SH3PXD2B",1.05017208670875E-5,5,171881532,38,3,"Up"]
["LOC387647",1.06302115165151E-5,10,29698453,18,3,"Down"]
["BAT3",1.07941683340226e-05,6,31615245,2292,4,"Up"]
["-",1.07941683340226e-05,7,42895232,3196,4,"Up"]
["CYP2W1",1.12917313819158e-05,7,1022774,134,3,"Down"]
["MIR574; FAM114A1",1.41065445019469E-5,4,38869629,156,3,"Down"]
["-",1.4910156909524E-5,22,42548710,164,3,"Up"]
["-",1.4910156909524E-5,14,70689343,2306,3,"Up"]
["TNXB",1.61432273257046e-05,6,32048334,2022,4,"Up"]
["KCTD12",1.88788267229092e-05,13,77461305,126,3,"Up"]
["BRSK2",1.8962876638048E-5,11,1463397,409,4,"Down"]
["KLF11",1.99851514798872E-5,2,10183088,54,3,"Down"]
["HLA-DQB1",2.11554635048361e-05,6,32632859,211,3,"Down"]
["FOXK1",2.11554635048361e-05,7,4760950,2499,4,"Down"]
["RADIL",2.14020260995229e-05,7,4858386,1905,3,"Up"]
["-",2.33922261303452e-05,8,832850,360,3,"Down"]
["CMYA5",2.38746877088483e-05,5,78985455,890,5,"Down"]
["LOC339290; C18orf18",2.40911790063042e-05,18,5238564,288,3,"Down"]
["CATSPER4",2.42217475524408e-05,1,26527425,948,3,"Up"]
["-",2.58106467140857e-05,10,3281120,2576,3,"Up"]
["-",2.8536868073158e-05,7,98334052,2547,4,"Up"]
["FLJ12825",2.8536868073158e-05,12,54454019,288,3,"Down"]
["-",2.8536868073158e-05,8,689746,475,3,"Down"]
["RNU5E; RNU5D; CKMT2",2.90584256050405e-05,5,80528622,958,3,"Down"]
["UBD",2.91028915132826E-5,6,29523133,1827,3,"Down"]
["ADAM5P",2.91028915132826E-5,8,39172072,73,4,"Up"]
["TRIM6-TRIM34; TRIM6",3.10592558960484e-05,11,5617165,231,3,"Down"]
["BDKRB2",3.13475257669794e-05,14,96670526,216,3,"Up"]
["TBCD",3.16078907884735e-05,17,80875553,1264,3,"Up"]
["CDKL5",3.16666891292338e-05,"X",18443697,86,6,"Down"]
["KIAA1026",3.16666891292338e-05,1,15392348,1004,3,"Down"]
["REEP4",3.19488216215657e-05,8,21995391,2091,3,"Up"]
["ZFYVE28",3.35236604968907e-05,4,2402938,2189,3,"Down"]
["MESTIT1; MEST",3.38959958451141e-05,7,130130045,288,3,"Down"]
["-",3.45282289673895e-05,12,115131576,3496,4,"Down"]
["BRSK2",3.80669346938328e-05,11,1422118,1274,3,"Down"]
["MC4R",4.93515607422301e-05,18,58036567,4002,3,"Up"]
["GADL1",5.11454776207763e-05,3,30936238,18,3,"Up"]
["-",5.15924503088874e-05,2,66656165,3496,4,"Down"]
["-",5.38172869517168e-05,11,133656355,2869,3,"Up"]
["LOC151174; LOC643387",6.20718467055497e-05,2,239139767,409,3,"Up"]
["WIPI2",6.21032383797121E-5,7,5270700,4201,4,"Up"]
["-",6.21032383797121E-5,10,45359449,434,3,"Up"]
["IFNGR2",6.50905361228879e-05,21,34775015,47,3,"Down"]
["CCNA1",6.50905361228879e-05,13,37004674,126,3,"Up"]
["MRGPRF",7.13621959836791E-5,11,68781186,186,3,"Down"]
["-",7.17336019205377e-05,7,187092,409,3,"Down"]
["-",7.34971613527624E-5,11,2307251,2969,3,"Up"]
["PNLDC1",7.34971613527624E-5,6,160239555,4002,4,"Up"]
["MIR941-1; DNAJC5; MIR941-3; MIR941-2",8.49177899828274e-05,20,62549296,126,6,"Down"]
["RFPL3",8.5821528427242e-05,22,32750641,480,3,"Down"]
["BCL7A",8.68181345517649e-05,12,122495825,5814,3,"Down"]
["-",8.91082116324059e-05,7,38355618,3177,3,"Up"]
["PDE4D",9.42187706128604E-5,5,59189646,281,4,"Down"]
["CDSN; PSORS1C1",9.65325653800136e-05,6,31087968,574,4,"Down"]
["RNF5P1; RNF5; AGPAT1",9.70715329794659e-05,6,32145444,290,3,"Up"]
["CREB5",9.70715329794659e-05,7,28450497,3203,4,"Up"]
["-",0.000101960394530214,5,1866867,2505,3,"Up"]
["NPAS4",1.27779392921189E-4,11,66191930,4139,3,"Up"]
["-",0.000143417974511548,13,110767382,2412,3,"Down"]
["OAT",0.000143626721891696,10,126106440,289,3,"Down"]
["-",1.49542319615879E-4,6,1593300,3547,3,"Up"]
["-",0.000158567921614158,18,44773903,233,3,"Down"]
["-",1.63166579773573E-4,1,247802541,324,3,"Up"]
["GRB7",0.000164217193156836,17,37894018,480,3,"Down"]
["HIVEP3",0.000170659546554997,1,42384298,134,3,"Up"]
["CACNB2",0.00018407512745791,10,18688985,963,4,"Up"]
["-",0.000191565266050682,6,158374573,2352,3,"Up"]
["KCNE1L",2.2921878002624E-4,"X",108868228,86,6,"Down"]
["-",2.2921878002624E-4,16,87026211,2562,3,"Down"]
["STAG3; GPC2",2.2921878002624E-4,7,99775515,86,3,"Down"]
["-",2.2921878002624E-4,5,1961200,2465,3,"Down"]
["CPT1B; CHKB-CPT1B",2.2921878002624E-4,22,51016555,140,4,"Up"]
["MOG",0.000238003168439136,6,29629271,1162,3,"Down"]
["HLA-C",0.000238003168439136,6,31239165,233,3,"Down"]
["-",0.000253833923083293,6,27235511,2466,3,"Up"]
["KCNJ15",0.000261585322865212,21,39643976,618,3,"Down"]
["RIC3",0.000262823654461069,11,8190759,141,3,"Down"]
["MIR663",2.8595141458894E-4,20,26190291,126,6,"Up"]
["DEFB1",2.8595141458894E-4,8,6735232,518,3,"Down"]
["-",0.000299388094015886,6,166259208,2867,3,"Up"]
["C19orf30",3.04581155323634E-4,19,4768701,890,3,"Down"]
["-",3.06772214527196E-4,12,50443411,3103,3,"Down"]
["-",0.000312442122285805,10,134885014,3496,3,"Down"]
["ZNF19",0.000313086265341672,16,71523367,216,3,"Up"]
["-",0.000322788682720659,6,6892973,2320,3,"Up"]
["BFSP2",0.00032882293079494,3,133190825,1027,3,"Down"]
["WRB",0.000362244665599248,21,40759430,408,3,"Up"]
["DDO",0.000390577563936493,6,110736850,216,3,"Down"]
["SRPK3",0.000390577563936493,"X",153046431,100,3,"Up"]
["NCOR2",0.000409175273450662,12,124907774,1989,3,"Up"]
["MGAT5B",0.000427246939347294,17,74867827,2017,3,"Up"]
["-",0.000435427199446752,13,21900230,324,3,"Down"]
["-",0.000449636503178625,11,123939455,2335,3,"Up"]
["MUC21",0.000482950283304524,6,30954602,4002,3,"Up"]
["TRIM27",0.000482950283304524,6,28871890,1209,3,"Up"]
["KRTAP12-3; C21orf29",0.000502541684380133,21,46077690,66,3,"Down"]
["MAL2",0.000515537038851726,8,120219987,170,3,"Up"]
["TCF19",0.000519202548721291,6,31128837,2404,3,"Down"]
["C10orf93",5.20902149151398E-4,10,134750830,2196,3,"Up"]
["SH2B2",5.20902149151398E-4,7,101936284,156,3,"Down"]
["S100P",0.000533778018962151,4,6695211,216,3,"Down"]
["STOX2",0.000533829155041541,4,184908065,1174,3,"Up"]
["-",0.000541772520661554,1,39281725,324,3,"Down"]
["TNXB",0.000575071983329029,6,32036573,890,3,"Down"]
["RGMA",0.00058986428717289,15,93616865,156,3,"Down"]
["-",0.000773383757916582,2,173537980,2752,3,"Down"]
["SIAH3",0.000867672140962244,13,46425597,480,3,"Up"]
["PDCL2",0.000887817817182635,4,56458093,517,3,"Up"]
["CPLX2",0.000975255171162194,5,175294589,3138,3,"Up"]
["-",0.00176878343482458,4,54968427,3575,3,"Down"]
[]
["SOM Table 8. Differentially methylated regions (DMRs) identified in carriers of the linked haplotye (LH) compared to married in controls (MI), ranked by p-value. aGRCh37/hg19. bThe direction of change is indicated with respect to the MI group.\n"]

{"sheet":"SOM Table 9","index":8,"n_rows":123,"n_cols":7,"rows_kept":123,"merged":[[122,0,122,6]]}
["Gene Symbol","p-value","Chr.","Start coordinatea","Length","No. probes","Directionb"]
["HOXA5",5.84623606278211e-61,7,27183659,829,29,"Down"]
["RNF5P1; RNF5; AGPAT1",7.45936548666568e-27,6,32145057,1650,25,"Up"]
["CPT1B; CHKB-CPT1B",1.75886601354837e-17,22,51016555,628,13,"Up"]
["STK32C",8.58506023273784e-14,10,134043054,3398,11,"Up"]
["TNXB",5.9122693149999e-12,6,32075839,818,6,"Up"]
["BAT1; SNORD84",1.84653522443149e-10,6,31509237,305,4,"Down"]
["RNF39",2.57528701764509e-09,6,30039296,448,7,"Up"]
["-",2.83522695136699e-09,6,32221987,2554,4,"Up"]
["-",4.59570272100625e-09,10,125032659,3270,7,"Up"]
["TRAPPC9",4.69343246468091e-09,8,141359530,288,4,"Up"]
["GALNT2",2.02382362546072E-8,1,230415047,356,4,"Down"]
["-",9.13015341903753e-08,6,29647050,2817,10,"Up"]
["NUDT12",1.28952762034327E-7,5,102898223,618,6,"Down"]
["PPP1R2P1",1.58549489154598e-07,6,32847452,456,8,"Up"]
["-",4.73809602460048e-07,17,406344,164,3,"Down"]
["RPS6KA2",4.73809602460048e-07,6,166876090,1181,4,"Down"]
["-",1.01155435955702E-6,6,29932586,2496,4,"Up"]
["C8orf31",1.17873943033033e-06,8,144120291,494,7,"Down"]
["-",2.58695850240464e-06,14,106327859,3541,4,"Down"]
["NPAS4",2.58695850240464e-06,11,66191930,4139,3,"Up"]
["MC4R",2.87481814055591E-6,18,58036567,4002,4,"Up"]
["-",2.89484676900697e-06,6,28956162,323,6,"Down"]
["NFYA; LOC221442",3.59063440104493e-06,6,41068597,224,6,"Down"]
["-",4.18313277703134e-06,6,29520851,334,3,"Down"]
["GPR133",5.01186760037348e-06,12,131616599,938,3,"Down"]
["-",5.849867006701e-06,7,42895232,3196,4,"Up"]
["PRSSL1",6.04904140107459e-06,19,693994,1693,5,"Up"]
["BRSK2",6.26960799908419E-6,11,1413138,288,3,"Up"]
["BRSK2",6.26960799908419E-6,11,1463397,409,4,"Down"]
["-",7.3433427553251e-06,8,1365497,324,3,"Down"]
["HLA-DPB2",9.80891553337609e-06,6,33090912,1328,4,"Up"]
["STOX2",9.80891553337609e-06,4,184908065,1264,5,"Up"]
["BFSP2",1.04454435333887e-05,3,133190825,1027,3,"Down"]
["SORD",1.07063339496278E-5,15,45314852,154,3,"Up"]
["WIPI2",1.51823297708078E-5,7,5270274,4627,5,"Up"]
["KCNQ1DN",1.62477581629024e-05,11,2890423,77,4,"Up"]
["TNXB",1.62477581629024e-05,6,32063295,350,5,"Up"]
["BRSK2",1.62845798715336e-05,11,1422118,1274,3,"Down"]
["-",1.84883531236803e-05,22,42548710,164,3,"Up"]
["DSCAML1",1.90880824236178e-05,11,117668026,23,3,"Up"]
["BAI1",2.07198463277571e-05,8,143546681,356,3,"Up"]
["KLF6",2.07198463277571e-05,10,3824372,327,4,"Down"]
["HLA-C",2.07198463277571e-05,6,31239165,237,4,"Down"]
["-",2.20650301065562e-05,8,832850,360,3,"Down"]
["TNFAIP2",3.10124116543651e-05,14,103593425,173,3,"Down"]
["-",3.21248978195861e-05,5,140419031,2582,3,"Down"]
["-",3.21248978195861e-05,1,117316792,2504,3,"Up"]
["PCGF3",3.26783986672783e-05,4,717500,4878,4,"Up"]
["-",3.34335455540129e-05,10,134885014,3496,3,"Down"]
["SLC38A4",4.53554938439891e-05,12,47219386,480,5,"Up"]
["RECQL5; LOC643008",4.60722202871218e-05,17,73630942,1686,3,"Up"]
["SCRIB; MIR937",4.74386868507291E-5,8,144896032,419,3,"Down"]
["-",5.07452768647505e-05,8,1957694,4520,4,"Up"]
["DEFB1",5.31408972796769e-05,8,6735232,518,3,"Down"]
["-",5.36739989145207E-5,5,2223997,2515,3,"Down"]
["BAT3",5.36739989145207E-5,6,31615245,2292,4,"Up"]
["TCF19",5.36739989145207E-5,6,31128783,2534,5,"Down"]
["BCL7A",5.48031556385233E-5,12,122495825,5814,3,"Down"]
["-",6.35631786789347E-5,14,104667716,2316,3,"Up"]
["STAG3; GPC2",7.0251350302612e-05,7,99775515,86,3,"Down"]
["NFKBIL1; ATP6V1G2",7.0251350302612e-05,6,31515158,540,3,"Down"]
["SH2B2",7.0251350302612e-05,7,101936284,156,3,"Down"]
["LRRC23; ENO2",7.82710909322526e-05,12,7023017,356,4,"Up"]
["MESTIT1; MEST",8.67971481789423e-05,7,130130043,421,3,"Down"]
["MRGPRF",9.07495838385233e-05,11,68781186,186,3,"Down"]
["CDSN; PSORS1C1",9.07495838385233e-05,6,31088326,216,3,"Down"]
["FOXK1",1.03792468996931E-4,7,4760950,2264,3,"Down"]
["PITPNC1",1.04715678281438E-4,17,65470858,1048,3,"Up"]
["-",1.04715678281438E-4,6,29895013,409,4,"Down"]
["-",1.04857332842206E-4,14,70689343,2306,3,"Up"]
["HLA-DQA2",1.09274377879463E-4,6,32711172,1318,3,"Up"]
["-",1.09274377879463E-4,7,38355618,3177,3,"Up"]
["ZFYVE28",1.09274377879463E-4,4,2402938,2189,3,"Down"]
["-",1.09274377879463E-4,1,2837694,2347,3,"Down"]
["HLA-DQB1",0.000123662777292721,6,32632859,211,3,"Down"]
["-",0.000125942365072142,13,110767382,2412,3,"Down"]
["SUCLA2",0.000125942365072142,13,48575834,126,6,"Up"]
["LOC399815; FAM24B",0.000125942365072142,10,124639079,156,4,"Up"]
["IGF2BP1",0.000132230543494448,17,47093409,1686,3,"Up"]
["SLC7A5",0.000136316625953753,16,87866251,1027,3,"Down"]
["-",0.000137402877010323,6,28555640,3882,3,"Down"]
["IFNGR2",0.000137402877010323,21,34775015,47,3,"Down"]
["OAT",0.000137402877010323,10,126106440,289,3,"Down"]
["TRIM6-TRIM34; TRIM6",1.40953833875738E-4,11,5617165,231,3,"Down"]
["CCNA1",1.46828574997716E-4,13,37004674,126,6,"Up"]
["-",0.000152099144319419,2,242712042,3797,3,"Down"]
["MOG",0.000159353262318511,6,29629271,1162,3,"Down"]
["GSTM5",0.000159733673686919,1,110254817,158,3,"Down"]
["HLA-B",0.000177642918226746,6,31324923,98,3,"Down"]
["-",0.000185850607049404,12,50443411,3103,3,"Down"]
["-",2.05490038168743E-4,6,27235511,2466,3,"Up"]
["-",2.10100031660678E-4,7,98334052,2547,3,"Up"]
["-",2.32333219910948E-4,1,175855670,3229,3,"Down"]
["VKORC1L1",2.41724211799887E-4,7,65417287,4002,3,"Up"]
["-",0.000247183098597832,2,863727,324,3,"Up"]
["MAGEE2",0.000247183098597832,"X",75004788,480,4,"Up"]
["CYP27C1",0.000248817696790215,2,127963482,216,4,"Up"]
["-",0.000252023481537046,11,123939455,2335,3,"Up"]
["FRMD4A",0.000264920271136666,10,14051204,1269,3,"Down"]
["KCTD12",2.80862184382119E-4,13,77461305,126,3,"Up"]
["-",0.000280902276387978,6,1593300,3547,3,"Up"]
["CYP2W1",0.000288631256849876,7,1022774,134,3,"Down"]
["ERICH1",0.000330040168788516,8,640623,1717,3,"Down"]
["ADAM5P",3.5673717801088E-4,8,39172072,64,3,"Up"]
["LOC149837",3.85079160481154E-4,20,5485259,50,3,"Up"]
["RPH3AL",3.85079160481154E-4,17,153828,1686,3,"Down"]
["-",0.000420208794365003,8,583875,2222,3,"Down"]
["-",0.000420208794365003,13,21900230,324,3,"Down"]
["LOC151174; LOC643387",0.000450978271126775,2,239139767,409,3,"Up"]
["CAPN2",4.9303231390778E-4,1,223936721,195,3,"Down"]
["SMC1B; RIBC2",0.000521927229057672,22,45809241,156,3,"Up"]
["C6orf25",0.000540434113438634,6,31692090,349,3,"Up"]
["FGF8",0.000551555547058652,10,103529733,967,3,"Up"]
["TRPM5",0.000644207172484303,11,2434007,355,3,"Up"]
["C22orf9; MIR1249",0.000674459036196537,22,45596825,299,3,"Up"]
["FLJ12825",0.00068856671651939,12,54454019,288,3,"Down"]
["KLHL1; ATXN8OS",0.000788468242449947,13,70681132,329,3,"Up"]
["ELFN1",0.000993388270141905,7,1780431,3138,3,"Up"]
["UBE2QL1",1.39891358106434E-3,5,6447172,148,3,"Up"]
["VARS",1.53327907712568E-3,6,31746496,972,3,"Down"]
[]
["SOM Table 9. Differentially methylated regions (DMRs) identified in unaffected carriers of the linked haplotye (ULH) compared to married in controls (MI), ranked by p-value. aGRCh37/hg19. bThe direction of change is indicated with respect to the MI group.\n"]

{"sheet":"SOM Table 10","index":9,"n_rows":52,"n_cols":7,"rows_kept":52,"merged":[[51,0,51,6]]}
["Gene Symbol","p-value","Chr.","Start coordinatea","Length","No. probes","Directionb"]
["AGPAT1; RNF5; RNF5P1",1.19212193597973e-20,6,32145242,1461,22,"Down"]
["KRT3",1.36616884166449E-13,12,53183861,369,4,"Up"]
["B3GALT4",1.30344503718051e-11,6,33245518,353,10,"Down"]
["-",5.81152664306015e-08,10,23490722,3496,4,"Up"]
["GADL1",6.26801491630563e-08,3,30936238,18,3,"Up"]
["ZNF264",1.92530626566252e-06,19,57702317,246,5,"Down"]
["CAMTA1",5.54315446406374e-06,1,7307567,1244,4,"Up"]
["-",7.95608213301231e-06,7,3226151,2292,3,"Up"]
["PITPNC1",1.82132421038484E-5,17,65470858,1048,3,"Down"]
["C20orf199; SNORD12",1.82132421038484E-5,20,47896417,1686,5,"Up"]
["PTPRN2",1.82132421038484E-5,7,157368737,383,4,"Up"]
["ADCY4",1.99956032210524e-05,14,24801047,288,3,"Down"]
["TNFAIP8",3.02785829810996E-5,5,118603817,184,3,"Up"]
["FGFR2",3.02785829810996E-5,10,123356121,230,3,"Down"]
["CDK16",3.02785829810996E-5,"X",47077864,151,5,"Down"]
["-",4.25502138062311e-05,4,8701168,2418,3,"Down"]
["-",5.31639847350261e-05,17,43222024,179,3,"Down"]
["RAET1L",5.31639847350261e-05,6,150346813,216,4,"Up"]
["C11orf87",5.31639847350261e-05,11,109294141,98,3,"Up"]
["ZNF833",5.31639847350261e-05,19,11785047,219,4,"Up"]
["-",6.48604235723528e-05,15,29967962,324,3,"Up"]
["VARS2; GTF2H4",6.48604235723528e-05,6,30881616,75,3,"Down"]
["HTR2A",6.48604235723528e-05,13,47472142,309,4,"Down"]
["-",6.48604235723528e-05,6,156884560,2295,3,"Up"]
["PIWIL1",7.92572487128709e-05,12,130824213,230,3,"Up"]
["S100A6",7.97850928676839e-05,1,153508462,129,3,"Up"]
["TMEM72",0.000153189984160194,10,45406524,563,3,"Down"]
["CPT1B; CHKB-CPT1B",0.000153189984160194,22,51017134,49,3,"Down"]
["-",0.000162529567498287,11,43289847,2307,3,"Up"]
["GSTM5",0.000191873285809368,1,110254810,165,4,"Up"]
["MAGEE2",0.000191873285809368,"X",75004703,480,3,"Down"]
["PPP2R2D",0.000191873285809368,10,133760330,1302,4,"Down"]
["HLA-DRB1",0.000297785233681017,6,32551961,223,3,"Down"]
["SH3TC1",0.000322577822819351,4,8230244,1048,3,"Down"]
["-",0.000374166686995075,7,32356953,2698,3,"Up"]
["-",0.000400693771703073,8,583875,2222,3,"Up"]
["KCNMB3",0.00043504760765796,3,178984507,480,3,"Up"]
["DDR1",0.00052138134608574,6,30859569,1141,3,"Up"]
["TNFRSF11A",0.00052138134608574,18,60052286,356,3,"Up"]
["MAD1L1",0.000524711064922511,7,1886758,379,3,"Down"]
["-",0.000551266855079712,11,2210828,2508,3,"Up"]
["SPEF2",0.000621929838067763,5,35617624,179,3,"Up"]
["DOK6",7.89798394987757E-4,18,67070042,156,3,"Down"]
["SLC1A3",8.88211502444909E-4,5,36662359,1036,3,"Down"]
["-",8.88211502444909E-4,13,79166335,3496,3,"Up"]
["NPAS4",0.000903669182671181,11,66191930,4139,3,"Down"]
["-",0.000918735239188001,15,69754560,2296,3,"Down"]
["STK32C",1.10488441488682E-3,10,134062077,890,3,"Up"]
["TMCO3",1.35511382168559E-3,13,114192846,1686,3,"Up"]
[]
["SOM Table 10. Differentially methylated regions (DMRs) identified in affected carriers of the linked haplotye (ALH) compared to unaffected carriers of the linked haplotype (ULH), ranked by p-value.  aGRCh37/hg19. bThe direction of change is indicated with respect to the ULH group.\n"]

{"sheet":"SOM Table 11","index":10,"n_rows":161,"n_cols":9,"rows_kept":161,"merged":[[160,0,160,8]]}
["GO Term","Description","p-value","q-value","Enrichment","N","B","n2","b3"]
["GO:0048856","anatomical structure development",2.45e-10,3.37e-06,1.35,17686,2713,1967,407]
["GO:0048518","positive regulation of biological process",2.62e-10,1.8e-06,1.23,17686,5130,2014,716]
["GO:0048522","positive regulation of cellular process",3.41E-9,1.57e-05,1.23,17686,4445,2014,625]
["GO:0048869","cellular developmental process",4.82e-09,1.66E-5,1.35,17686,2434,1895,353]
["GO:0007389","pattern specification process",1.52E-8,4.19e-05,1.98,17686,375,1880,79]
["GO:0032502","developmental process",1.89E-8,4.34e-05,1.23,17686,4584,1899,604]
["GO:0045893","positive regulation of transcription, DNA-templated",2.03E-8,3.99e-05,1.46,17686,1411,1951,227]
["GO:1903508","positive regulation of nucleic acid-templated transcription",2.03E-8,3.49e-05,1.46,17686,1411,1951,227]
["GO:1902680","positive regulation of RNA biosynthetic process",2.63e-08,4.03e-05,1.45,17686,1438,1951,230]
["GO:0009653","anatomical structure morphogenesis",4.46e-08,6.15e-05,1.47,17686,1330,1899,210]
["GO:0044767","single-organism developmental process",9e-08,1.13E-4,1.23,17686,4194,1875,548]
["GO:0051254","positive regulation of RNA metabolic process",9.78e-08,1.12E-4,1.43,17686,1475,1951,232]
["GO:0045165","cell fate commitment",1.03E-7,0.000109,2.52,17686,144,1947,40]
["GO:0010557","positive regulation of macromolecule biosynthetic process",1.99E-7,0.000196,1.4,17686,1603,1951,247]
["GO:0051960","regulation of nervous system development",2.16E-7,0.000199,1.63,17686,676,1989,124]
["GO:0031328","positive regulation of cellular biosynthetic process",2.88e-07,0.000248,1.38,17686,1718,1951,261]
["GO:0050793","regulation of developmental process",4.67e-07,3.79E-4,1.34,17686,2019,1951,298]
["GO:0048663","neuron fate commitment",5.14e-07,0.000394,4.36,17686,37,1865,17]
["GO:0045935","positive regulation of nucleobase-containing compound metabolic process",9.11e-07,0.000661,1.37,17686,1662,1951,251]
["GO:0009891","positive regulation of biosynthetic process",1.01e-06,0.000695,1.36,17686,1750,1951,262]
["GO:0009893","positive regulation of metabolic process",1.06E-6,0.000694,1.24,17686,3406,2013,479]
["GO:0044763","single-organism cellular process",1.09e-06,0.000681,1.12,17686,9447,1566,938]
["GO:0032879","regulation of localization",1.4e-06,0.000838,1.3,17686,2218,2014,329]
["GO:0010628","positive regulation of gene expression",1.61E-6,0.000924,1.36,17686,1665,1951,250]
["GO:0023051","regulation of signaling",1.87e-06,0.00103,1.26,17686,2775,1986,394]
["GO:2000026","regulation of multicellular organismal development",1.94e-06,0.00103,1.38,17686,1509,1936,228]
["GO:0051173","positive regulation of nitrogen compound metabolic process",2.35e-06,0.0012,1.35,17686,1735,1951,258]
["GO:0048519","negative regulation of biological process",2.97e-06,0.00146,1.2,17686,4276,2006,580]
["GO:0045944","positive regulation of transcription from RNA polymerase II promoter",3.55e-06,0.00169,1.46,17686,1004,1951,162]
["GO:0048731","system development",3.63E-6,1.66E-3,1.59,17686,671,1853,112]
["GO:0035239","tube morphogenesis",4.52e-06,0.00201,2.02,17686,224,1951,50]
["GO:0050789","regulation of biological process",5.35e-06,2.3E-3,1.09,17686,10226,2014,1270]
["GO:0010646","regulation of cell communication",5.42e-06,0.00226,1.25,17686,2830,2002,400]
["GO:0008285","negative regulation of cell proliferation",6.04e-06,0.00245,1.58,17686,630,1952,110]
["GO:0006357","regulation of transcription from RNA polymerase II promoter",6.8e-06,0.00268,1.33,17686,1727,1951,254]
["GO:0048583","regulation of response to stimulus",1.08E-5,4.15E-3,1.22,17686,3396,2014,470]
["GO:0050870","positive regulation of T cell activation",1.2E-5,0.00446,2.54,17686,185,1131,30]
["GO:0051094","positive regulation of developmental process",1.21e-05,0.00437,1.42,17686,1091,1951,171]
["GO:0010604","positive regulation of macromolecule metabolic process",1.29E-5,0.00454,1.25,17686,2738,1951,377]
["GO:0051239","regulation of multicellular organismal process",1.51e-05,0.0052,1.27,17686,2351,1955,330]
["GO:0050767","regulation of neurogenesis",1.52E-5,0.00512,1.57,17686,588,1989,104]
["GO:0031325","positive regulation of cellular metabolic process",1.67e-05,0.00549,1.24,17686,2795,1951,383]
["GO:0048562","embryonic organ morphogenesis",1.72e-05,0.00553,2.45,17686,123,1880,32]
["GO:0065007","biological regulation",1.75e-05,5.47E-3,1.08,17686,10739,2014,1322]
["GO:0034112","positive regulation of homotypic cell-cell adhesion",1.83e-05,5.62E-3,2.48,17686,189,1131,30]
["GO:0050794","regulation of cellular process",1.89e-05,0.00567,1.09,17686,9727,2014,1209]
["GO:0048513","organ development",1.94e-05,0.00567,1.4,17686,1186,1898,178]
["GO:1903039","positive regulation of leukocyte cell-cell adhesion",1.95E-5,0.0056,2.47,17686,190,1131,30]
["GO:0030154","cell differentiation",2e-05,0.00563,1.33,17686,1681,1921,242]
["GO:0048523","negative regulation of cellular process",2.24e-05,0.00617,1.19,17686,3950,2014,535]
["GO:0048468","cell development",2.35e-05,0.00633,1.66,17686,572,1544,83]
["GO:0001763","morphogenesis of a branching structure",2.71e-05,0.00719,2.11,17686,163,1951,38]
["GO:0022409","positive regulation of cell-cell adhesion",3.14e-05,0.00815,2.15,17686,222,1411,38]
["GO:0003002","regionalization",4.23e-05,0.0108,1.91,17686,238,1865,48]
["GO:0048754","branching morphogenesis of an epithelial tube",4.33e-05,0.0108,2.21,17686,131,1951,32]
["GO:0001709","cell fate determination",5.43e-05,0.0134,3.66,17686,45,1610,15]
["GO:0002460","adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains",5.61e-05,0.0136,13.49,17686,57,138,6]
["GO:0048598","embryonic morphogenesis",5.62e-05,0.0134,1.67,17686,405,1880,72]
["GO:0044707","single-multicellular organism process",7e-05,0.0163,1.25,17686,3286,1378,320]
["GO:2000027","regulation of organ morphogenesis",7.41e-05,0.017,2.09,17686,156,1895,35]
["GO:0030001","metal ion transport",7.54e-05,0.017,1.68,17686,582,1300,72]
["GO:0071805","potassium ion transmembrane transport",7.57e-05,0.0168,4.84,17686,140,287,11]
["GO:0071804","cellular potassium ion transport",7.57e-05,0.0166,4.84,17686,140,287,11]
["GO:0046639","negative regulation of alpha-beta T cell differentiation",8.49e-05,0.0183,9.74,17686,13,838,6]
["GO:0061138","morphogenesis of a branching epithelium",8.51e-05,0.018,2.07,17686,153,1951,35]
["GO:0010870","positive regulation of receptor biosynthetic process",8.58e-05,0.0179,327.52,17686,12,9,2]
["GO:0030182","neuron differentiation",9.17e-05,0.0188,1.88,17686,231,1875,46]
["GO:0045597","positive regulation of cell differentiation",9.53e-05,0.0193,1.55,17686,788,1390,96]
["GO:0045785","positive regulation of cell adhesion",9.65e-05,0.0193,1.96,17686,351,1131,44]
["GO:0002009","morphogenesis of an epithelium",9.84e-05,0.0194,2.18,17686,293,942,34]
["GO:0032989","cellular component morphogenesis",0.000104,0.0201,1.61,17686,452,1895,78]
["GO:0030029","actin filament-based process",1.05E-4,0.02,1.72,17686,321,1917,60]
["GO:0045595","regulation of cell differentiation",1.1E-4,0.0208,1.33,17686,1393,1951,204]
["GO:0051049","regulation of transport",1.16E-4,0.0216,1.29,17686,1681,2014,247]
["GO:0009966","regulation of signal transduction",0.000119,0.0219,1.24,17686,2453,1951,335]
["GO:0060284","regulation of cell development",0.000124,0.0224,1.45,17686,756,1989,123]
["GO:0048729","tissue morphogenesis",0.000128,0.0229,2.02,17686,362,969,40]
["GO:0022603","regulation of anatomical structure morphogenesis",0.000129,0.0228,1.43,17686,852,1919,132]
["GO:0031330","negative regulation of cellular catabolic process",1.34E-4,0.0233,2.05,17686,154,1905,34]
["GO:0046637","regulation of alpha-beta T cell differentiation",1.35E-4,0.0233,4.26,17686,46,1082,12]
["GO:0006813","potassium ion transport",0.000148,0.0252,2.97,17686,151,710,18]
["GO:0030155","regulation of cell adhesion",0.000167,0.028,1.66,17686,597,1228,69]
["GO:0009880","embryonic pattern specification",1.75E-4,0.0291,3.66,17686,56,1209,14]
["GO:0034329","cell junction assembly",0.000177,0.029,1.98,17686,167,1921,36]
["GO:0032501","multicellular organismal process",1.83E-4,0.0296,1.25,17686,3340,1209,286]
["GO:0002521","leukocyte differentiation",1.84E-4,0.0294,2.64,17686,243,607,22]
["GO:0051962","positive regulation of nervous system development",1.84E-4,0.0291,1.62,17686,401,1936,71]
["GO:0009952","anterior/posterior pattern specification",0.000199,0.0312,2.16,17686,141,1683,29]
["GO:0051251","positive regulation of lymphocyte activation",2.03E-4,0.0315,2.07,17686,236,1228,34]
["GO:0060294","cilium movement involved in cell motility",0.000209,0.032,21.03,17686,3,841,3]
["GO:0048706","embryonic skeletal system development",0.00021,0.0318,4.33,17686,36,1249,11]
["GO:0045582","positive regulation of T cell differentiation",0.000226,0.0338,3.45,17686,71,1082,15]
["GO:0098662","inorganic cation transmembrane transport",0.000229,0.0339,2.03,17686,467,710,38]
["GO:0034330","cell junction organization",0.000246,0.0361,1.89,17686,195,1921,40]
["GO:0016043","cellular component organization",0.00025,0.0362,1.15,17686,4720,1967,604]
["GO:0045216","cell-cell junction organization",0.000253,0.0363,2,17686,166,1813,34]
["GO:0006266","DNA ligation",0.000265,0.0376,5.6,17686,11,2010,7]
["GO:0015672","monovalent inorganic cation transport",0.000286,0.0402,1.9,17686,428,935,43]
["GO:0006928","movement of cell or subcellular component",0.000305,0.0424,1.36,17686,1471,1392,158]
["GO:0071840","cellular component organization or biogenesis",0.000315,0.0434,1.15,17686,4755,1967,607]
["GO:0032571","response to vitamin K",0.000317,0.0432,90.01,17686,3,131,2]
["GO:0010869","regulation of receptor biosynthetic process",0.000322,0.0435,187.15,17686,21,9,2]
["GO:0051128","regulation of cellular component organization",0.000323,0.0431,1.25,17686,2008,2004,284]
["GO:0007166","cell surface receptor signaling pathway",3.3E-4,0.0437,1.24,17686,2158,1955,296]
["GO:0045621","positive regulation of lymphocyte differentiation",0.000353,0.0463,3.19,17686,82,1082,16]
["GO:0060562","epithelial tube morphogenesis",0.000355,0.0462,2.42,17686,94,1865,24]
["GO:0050678","regulation of epithelial cell proliferation",0.000362,0.0466,1.89,17686,273,1370,40]
["GO:2000765","regulation of cytoplasmic translation",3.79E-4,0.0483,9.09,17686,9,1081,5]
["GO:0034110","regulation of homotypic cell-cell adhesion",0.000383,0.0484,1.95,17686,287,1167,37]
["GO:0065001","specification of axis polarity",3.88E-4,0.0486,22.91,17686,4,579,3]
["GO:0048705","skeletal system morphogenesis",0.000402,0.0499,2.27,17686,112,1880,27]
["GO:0001569","patterning of blood vessels",0.000403,0.0496,4.35,17686,32,1270,10]
["GO:0098660","inorganic ion transmembrane transport",0.000404,0.0493,1.9,17686,551,710,42]
["GO:0048812","neuron projection morphogenesis",0.000409,0.0494,1.89,17686,179,1932,37]
["GO:0070588","calcium ion transmembrane transport",0.000416,0.0499,2.28,17686,135,1378,24]
["GO:0042127","regulation of cell proliferation",0.000421,0.05,1.39,17686,1425,1244,139]
["GO:0048704","embryonic skeletal system morphogenesis",0.000424,0.0499,2.49,17686,83,1880,22]
["GO:0022407","regulation of cell-cell adhesion",0.000438,0.0511,1.75,17686,358,1411,50]
["GO:0007626","locomotory behavior",0.000443,0.0513,1.93,17686,188,1703,35]
["GO:1903037","regulation of leukocyte cell-cell adhesion",0.000449,0.0515,1.96,17686,278,1167,36]
["GO:0060850","regulation of transcription involved in cell fate commitment",0.00045,0.0512,4.38,17686,20,1817,9]
["GO:0034332","adherens junction organization",4.64E-4,0.0525,2.59,17686,72,1895,20]
["GO:0003006","developmental process involved in reproduction",0.000471,0.0527,1.73,17686,553,998,54]
["GO:0006284","base-excision repair",4.95E-4,0.055,3.24,17686,48,1592,14]
["GO:0050863","regulation of T cell activation",0.000502,0.0553,1.96,17686,270,1167,35]
["GO:0051138","positive regulation of NK T cell differentiation",0.000506,0.0553,10.19,17686,5,1389,4]
["GO:0051136","regulation of NK T cell differentiation",0.000506,0.0548,10.19,17686,5,1389,4]
["GO:0045995","regulation of embryonic development",0.000528,0.0568,2.24,17686,111,1921,27]
["GO:0009895","negative regulation of catabolic process",0.00053,0.0566,1.82,17686,200,1940,40]
["GO:0051725","protein de-ADP-ribosylation",0.000536,0.0568,20.16,17686,4,658,3]
["GO:0050867","positive regulation of cell activation",0.000552,0.058,1.98,17686,269,1131,34]
["GO:0046638","positive regulation of alpha-beta T cell differentiation",5.62E-4,0.0587,4.3,17686,38,1082,10]
["GO:0030036","actin cytoskeleton organization",5.71E-4,0.0591,1.7,17686,271,1917,50]
["GO:0009790","embryo development",5.71E-4,0.0587,1.73,17686,250,1918,47]
["GO:0009887","organ morphogenesis",0.000579,0.0591,1.59,17686,447,1696,68]
["GO:0009950","dorsal/ventral axis specification",0.000583,0.0591,5.24,17686,13,1819,7]
["GO:1903513","endoplasmic reticulum to cytosol transport",0.000589,0.0592,33.24,17686,21,76,3]
["GO:0097485","neuron projection guidance",0.00059,0.0589,1.59,17686,552,1391,69]
["GO:0007411","axon guidance",0.00059,0.0585,1.59,17686,552,1391,69]
["GO:2000766","negative regulation of cytoplasmic translation",6.02E-4,0.0592,10.91,17686,6,1081,4]
["GO:0007599","hemostasis",0.000615,0.0601,2.37,17686,473,378,24]
["GO:0021877","forebrain neuron fate commitment",0.000615,0.0597,6.02,17686,10,1762,6]
["GO:0007409","axonogenesis",0.000618,0.0596,2.29,17686,100,1932,25]
["GO:1903772","regulation of viral budding via host ESCRT complex",0.000631,0.0604,9.6,17686,5,1474,4]
["GO:0070889","platelet alpha granule organization",0.000646,0.0614,72.78,17686,3,162,2]
["GO:0002696","positive regulation of leukocyte activation",0.000647,0.061,1.94,17686,260,1228,35]
["GO:0001501","skeletal system development",0.000658,0.0616,1.99,17686,167,1653,31]
["GO:0048505","regulation of timing of cell differentiation",0.00068,0.0633,5.11,17686,13,1865,7]
["GO:0006244","pyrimidine nucleotide catabolic process",0.000713,0.0659,6.29,17686,12,1405,6]
["GO:0023052","signaling",0.000714,0.0656,1.56,17686,794,1073,75]
["GO:0060083","smooth muscle contraction involved in micturition",0.000764,0.0697,14.76,17686,3,1198,3]
["GO:0045664","regulation of neuron differentiation",0.000888,0.0805,1.5,17686,475,1989,80]
["GO:0042326","negative regulation of phosphorylation",0.000921,0.0829,1.56,17686,380,1970,66]
["GO:0048732","gland development",0.000929,0.0831,2.21,17686,234,855,25]
["GO:0021924","cell proliferation in external granule layer",0.000943,0.0838,9.52,17686,6,1239,4]
["GO:0021930","cerebellar granule cell precursor proliferation",0.000943,0.0833,9.52,17686,6,1239,4]
["GO:0021515","cell differentiation in spinal cord",0.000944,0.0828,4.07,17686,41,1060,10]
["GO:0048557","embryonic digestive tract morphogenesis",0.000986,0.086,6.66,17686,19,838,6]
[]
["SOM Table 11. Significantly enriched molecular process gene ontology (GO) categories identified in the ALH vs. MI comparison. Molecular process GO categories showing significant enrichment were identified by performing ranked-list gene ontology  analysis using GOrilla. Benjamini-Hochberg q-values were calculated to correct for the number of GO categories assessed. Enrichment is defined as (b/n) / (B/N), where N is the total number of genes in the input list, B is the total number associated with a particular GO term, n is the number of genes in the top of the ranked input list, b is the number of genes in the top of the ranked input list associated with a particular GO term."]

{"sheet":"SOM Table 12","index":11,"n_rows":32,"n_cols":9,"rows_kept":32,"merged":[[31,0,31,8]]}
["GO Term","Description","p-value","q-value","Enrichment","N","B","n2","b3"]
["GO:0005515","protein binding",2.36e-06,0.01,1.1,17686,10184,1918,1211]
["GO:0005488","binding",2.58e-06,0.00549,1.06,17686,13465,1918,1549]
["GO:0043565","sequence-specific DNA binding",7.66e-06,0.0108,1.46,17686,990,1898,155]
["GO:0000981","RNA polymerase II transcription factor activity, sequence-specific DNA binding",1.07e-05,0.0113,1.58,17686,620,1915,106]
["GO:0001228","transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding",1.63E-5,0.0139,1.8,17686,318,1947,63]
["GO:0022832","voltage-gated channel activity",1.96e-05,0.0139,2.26,17686,185,1478,35]
["GO:0005244","voltage-gated ion channel activity",1.96e-05,0.0119,2.26,17686,185,1478,35]
["GO:0046873","metal ion transmembrane transporter activity",2.45e-05,0.013,1.77,17686,412,1600,66]
["GO:0001071","nucleic acid binding transcription factor activity",3.79E-5,0.0179,1.39,17686,1149,1915,173]
["GO:0003700","transcription factor activity, sequence-specific DNA binding",3.79E-5,0.0161,1.39,17686,1149,1915,173]
["GO:0022843","voltage-gated cation channel activity",4.64e-05,0.0179,2.47,17686,149,1300,27]
["GO:0071837","HMG box domain binding",7.83e-05,0.0277,5.36,17686,18,1649,9]
["GO:0003779","actin binding",9.57e-05,0.0313,1.75,17686,382,1589,60]
["GO:0015079","potassium ion transmembrane transporter activity",0.000104,0.0317,4.64,17686,146,287,11]
["GO:0005261","cation channel activity",0.000129,0.0365,1.74,17686,298,1944,57]
["GO:0008092","cytoskeletal protein binding",0.00014,0.0371,1.43,17686,792,1998,128]
["GO:0042609","CD4 receptor binding",1.65E-4,0.0412,34.12,17686,5,311,3]
["GO:0005267","potassium channel activity",0.000304,0.0717,5.18,17686,119,287,10]
["GO:0000989","transcription factor activity, transcription factor binding",0.00034,0.076,1.7,17686,563,1088,59]
["GO:0022890","inorganic cation transmembrane transporter activity",0.000347,0.0737,1.95,17686,511,710,40]
["GO:0046523","S-methyl-5-thioribose-1-phosphate isomerase activity",0.000396,0.0801,2526.57,17686,1,7,1]
["GO:0000988","transcription factor activity, protein binding",0.000402,0.0776,1.69,17686,567,1088,59]
["GO:0044212","transcription regulatory region DNA binding",0.000412,0.0761,1.46,17686,798,1577,104]
["GO:0022836","gated channel activity",0.000456,0.0807,1.74,17686,320,1588,50]
["GO:0001077","transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding",4.66E-4,0.0791,1.95,17686,228,1391,35]
["GO:0000975","regulatory region DNA binding",0.000511,0.0835,1.45,17686,802,1577,104]
["GO:0001067","regulatory region nucleic acid binding",0.000511,0.0804,1.45,17686,802,1577,104]
["GO:0042610","CD8 receptor binding",0.00053,0.0805,56.87,17686,2,311,2]
["GO:0003682","chromatin binding",0.000663,0.0972,1.52,17686,461,1965,78]
[]
["SOM Table 12. Significantly enriched biological function gene ontology (GO) categories identified in the ALH vs. MI comparison. Biological function GO categories showing significant enrichment were identified by performing ranked-list gene ontology  analysis using GOrilla. Benjamini-Hochberg q-values were calculated to correct for the number of GO categories assessed. Enrichment is defined as (b/n) / (B/N), where N is the total number of genes in the input list, B is the total number associated with a particular GO term, n is the number of genes in the top of the ranked input list, b is the number of genes in the top of the ranked input list associated with a particular GO term."]

{"sheet":"SOM Table 13","index":12,"n_rows":12,"n_cols":9,"rows_kept":12,"merged":[[11,0,11,8]]}
["GO Term","Description","p-value","q-value","Enrichment","N","B","n2","b3"]
["GO:0098797","plasma membrane protein complex",8.74e-06,0.0144,1.83,17686,499,1295,67]
["GO:0043234","protein complex",7.49e-05,0.0618,1.23,17686,4102,1199,343]
["GO:0042995","cell projection",1.26E-4,0.0692,1.42,17686,1330,1300,139]
["GO:0005901","caveola",0.000128,0.0526,3.4,17686,68,1224,16]
["GO:0044853","plasma membrane raft",0.000172,0.0569,3.19,17686,77,1224,17]
["GO:0032797","SMN complex",0.000276,0.0758,168.44,17686,10,21,2]
["GO:0097504","Gemini of coiled bodies",0.000276,0.065,168.44,17686,10,21,2]
["GO:0000139","Golgi membrane",0.000372,0.0767,1.51,17686,575,1837,90]
["GO:0032991","macromolecular complex",3.77E-4,0.0691,1.19,17686,4748,1199,384]
[]
["SOM Table 13. Significantly enriched cellular component gene ontology (GO) categories identified in the ALH vs. MI comparison. Cellular component GO categories showing significant enrichment were identified by performing ranked-list gene ontology  analysis using GOrilla. Benjamini-Hochberg q-values were calculated to correct for the number of GO categories assessed. Enrichment is defined as (b/n) / (B/N), where N is the total number of genes in the input list, B is the total number associated with a particular GO term, n is the number of genes in the top of the ranked input list, b is the number of genes in the top of the ranked input list associated with a particular GO term."]

{"sheet":"SOM Table 14","index":13,"n_rows":15,"n_cols":9,"rows_kept":15,"merged":[[14,0,14,8]]}
["GO Term","Description","p-value","q-value","Enrichment","N","B","n2","b3"]
["GO:0007156","homophilic cell adhesion via plasma membrane adhesion molecules",2.69E-12,3.7E-8,3.09,17686,149,1843,48]
["GO:0048856","anatomical structure development",5.03e-10,3.47e-06,1.35,17686,2713,1892,392]
["GO:0098742","cell-cell adhesion via plasma-membrane adhesion molecules",5.71e-10,2.62e-06,2.56,17686,199,1843,53]
["GO:0098609","cell-cell adhesion",3.91e-09,1.35e-05,1.81,17686,579,1853,110]
["GO:0032502","developmental process",2.56e-07,0.000706,1.21,17686,4584,1907,598]
["GO:0007155","cell adhesion",3.3e-07,0.000757,1.52,17686,983,1907,161]
["GO:0022610","biological adhesion",4.69e-07,0.000922,1.51,17686,987,1907,161]
["GO:0044767","single-organism developmental process",9.57e-07,1.65E-3,1.21,17686,4194,2021,578]
["GO:0097485","neuron projection guidance",7.61E-6,0.0117,1.63,17686,552,1912,97]
["GO:0007411","axon guidance",7.61E-6,0.0105,1.63,17686,552,1912,97]
["GO:0009653","anatomical structure morphogenesis",3.21e-05,0.0402,1.37,17686,1330,1887,194]
["GO:0045216","cell-cell junction organization",4.4e-05,0.0505,2.13,17686,166,1800,36]
[]
["SOM Table 14. Significantly enriched molecular process gene ontology (GO) categories identified in the ULH vs. MI comparison. Molecular process GO categories showing significant enrichment were identified by performing ranked-list gene ontology  analysis using GOrilla. Benjamini-Hochberg q-values were calculated to correct for the number of GO categories assessed. Enrichment is defined as (b/n) / (B/N), where N is the total number of genes in the input list, B is the total number associated with a particular GO term, n is the number of genes in the top of the ranked input list, b is the number of genes in the top of the ranked input list associated with a particular GO term."]

{"sheet":"SOM Table 15","index":14,"n_rows":4,"n_cols":9,"rows_kept":4,"merged":[[3,0,3,8]]}
["GO Term","Description","p-value","q-value","Enrichment","N","B","n2","b3"]
["GO:0005509","calcium ion binding",3.16e-05,0.0671,1.52,17686,664,1940,111]
[]
["SOM Table 15. Significantly enriched biological function gene ontology (GO) categories identified in the ULH vs. MI comparison. Biological function GO categories showing significant enrichment were identified by performing ranked-list gene ontology  analysis using GOrilla. Benjamini-Hochberg q-values were calculated to correct for the number of GO categories assessed. Enrichment is defined as (b/n) / (B/N), where N is the total number of genes in the input list, B is the total number associated with a particular GO term, n is the number of genes in the top of the ranked input list, b is the number of genes in the top of the ranked input list associated with a particular GO term."]

{"sheet":"SOM Table 16","index":15,"n_rows":8,"n_cols":9,"rows_kept":8,"merged":[[7,0,7,8]]}
["GO Term","Description","p-value","q-value","Enrichment","N","B","n2","b3"]
["GO:0030054","cell junction",1.88E-6,0.0031,1.47,17686,1100,1800,165]
["GO:0005911","cell-cell junction",1.18E-4,0.0976,1.89,17686,358,1227,47]
["GO:0042825","TAP complex",1.47E-4,0.0809,23.68,17686,3,747,3]
["GO:0044456","synapse part",0.00015,0.0619,1.54,17686,535,1907,89]
["GO:0098797","plasma membrane protein complex",2.72E-4,0.0897,1.7,17686,499,1251,60]
[]
["SOM Table 16. Significantly enriched cellular component gene ontology (GO) categories identified in the ULH vs. MI comparison. Cellular component GO categories showing significant enrichment were identified by performing ranked-list gene ontology  analysis using GOrilla. Benjamini-Hochberg q-values were calculated to correct for the number of GO categories assessed. Enrichment is defined as (b/n) / (B/N), where N is the total number of genes in the input list, B is the total number associated with a particular GO term, n is the number of genes in the top of the ranked input list, b is the number of genes in the top of the ranked input list associated with a particular GO term."]

{"sheet":"SOM Table 17","index":16,"n_rows":19,"n_cols":9,"rows_kept":19,"merged":[[18,0,18,8]]}
["GO Term","Description","p-value","q-value","Enrichment","N","B","n2","b3"]
["GO:0007156","homophilic cell adhesion via plasma membrane adhesion molecules",8.23e-19,1.13E-14,8.97,17686,149,410,31]
["GO:0098742","cell-cell adhesion via plasma-membrane adhesion molecules",7.34e-15,5.06e-11,6.72,17686,199,410,31]
["GO:0098609","cell-cell adhesion",1.52e-10,6.98e-07,2.91,17686,579,524,50]
["GO:0007155","cell adhesion",7.92e-08,0.000273,2.16,17686,983,524,63]
["GO:0022610","biological adhesion",9.16E-8,2.52E-4,2.15,17686,987,524,63]
["GO:0007399","nervous system development",1.44e-07,3.3E-4,3.85,17686,269,410,24]
["GO:0097485","neuron projection guidance",7.09e-07,1.4E-3,2.1,17686,552,885,58]
["GO:0007411","axon guidance",7.09e-07,0.00122,2.1,17686,552,885,58]
["GO:0048856","anatomical structure development",1.64e-05,0.0251,1.26,17686,2713,1738,337]
["GO:0045165","cell fate commitment",2.73E-5,0.0377,2.22,17686,144,1881,34]
["GO:0048731","system development",6.23e-05,0.078,1.67,17686,671,1200,76]
["GO:0019222","regulation of metabolic process",7.93e-05,0.0911,1.13,17686,6321,1972,796]
["GO:0090427","activation of meiosis",8.63e-05,0.0915,28.21,17686,3,627,3]
["GO:0048518","positive regulation of biological process",9.37e-05,0.0923,1.15,17686,5130,1953,652]
["GO:0009893","positive regulation of metabolic process",9.85e-05,0.0905,1.2,17686,3406,1948,449]
["GO:0051147","regulation of muscle cell differentiation",0.000104,0.0891,22.61,17686,149,21,4]
[]
["SOM Table 17. Significantly enriched molecular process gene ontology (GO) categories identified in the ALH vs. ULH comparison. Molecular process GO categories showing significant enrichment were identified by performing ranked-list gene ontology  analysis using GOrilla. Benjamini-Hochberg q-values were calculated to correct for the number of GO categories assessed. Enrichment is defined as (b/n) / (B/N), where N is the total number of genes in the input list, B is the total number associated with a particular GO term, n is the number of genes in the top of the ranked input list, b is the number of genes in the top of the ranked input list associated with a particular GO term."]

{"sheet":"SOM Table 18","index":17,"n_rows":4,"n_cols":9,"rows_kept":4,"merged":[[3,0,3,8]]}
["GO Term","Description","p-value","q-value","Enrichment","N","B","n2","b3"]
["GO:0005509","calcium ion binding",2.9e-08,0.000123,2.73,17686,664,420,43]
[]
["SOM Table 18. Significantly enriched biological function gene ontology (GO) categories identified in the ALH vs. ULH comparison. Biological function GO categories showing significant enrichment were identified by performing ranked-list gene ontology  analysis using GOrilla. Benjamini-Hochberg q-values were calculated to correct for the number of GO categories assessed. Enrichment is defined as (b/n) / (B/N), where N is the total number of genes in the input list, B is the total number associated with a particular GO term, n is the number of genes in the top of the ranked input list, b is the number of genes in the top of the ranked input list associated with a particular GO term."]

{"sheet":"SOM Table 19","index":18,"n_rows":79,"n_cols":9,"rows_kept":79,"merged":[[78,0,78,8]]}
["GO Term","Description","p-value","q-value","Enrichment","N","B","n2","b3"]
["GO:0048856","anatomical structure development",4.05e-09,5.58e-05,1.32,17686,2713,1984,403]
["GO:0009653","anatomical structure morphogenesis",1.59e-07,0.0011,1.44,17686,1330,2019,218]
["GO:0032502","developmental process",3.91e-07,1.8E-3,1.2,17686,4584,2019,628]
["GO:0048731","system development",1.45e-06,0.005,1.62,17686,671,1860,114]
["GO:0044767","single-organism developmental process",1.48E-6,0.00409,1.2,17686,4194,2019,576]
["GO:0060134","prepulse inhibition",3.28e-06,0.00753,6.64,17686,12,1998,9]
["GO:0007389","pattern specification process",3.44e-06,6.77E-3,1.78,17686,375,1989,75]
["GO:0023052","signaling",4.27e-06,0.00735,1.51,17686,794,2021,137]
["GO:0031294","lymphocyte costimulation",5.12e-06,0.00784,5.13,17686,67,721,14]
["GO:0044700","single organism signaling",5.81e-06,0.008,1.5,17686,791,2021,136]
["GO:0006939","smooth muscle contraction",1.01E-5,0.0127,4.53,17686,43,1272,14]
["GO:0007267","cell-cell signaling",1.21e-05,0.0139,1.5,17686,758,2021,130]
["GO:0031295","T cell costimulation",2.54e-05,0.0269,4.83,17686,66,721,13]
["GO:0001501","skeletal system development",4.48e-05,0.044,2.05,17686,167,2019,39]
["GO:0030029","actin filament-based process",4.64e-05,0.0427,1.91,17686,321,1444,50]
["GO:0023051","regulation of signaling",5.17e-05,0.0445,1.23,17686,2775,1969,380]
["GO:0048513","organ development",5.19e-05,0.0421,1.37,17686,1186,1956,180]
["GO:0048869","cellular developmental process",5.26e-05,0.0403,1.25,17686,2434,1923,331]
["GO:0048639","positive regulation of developmental growth",5.28e-05,0.0383,2.79,17686,153,911,22]
["GO:0009966","regulation of signal transduction",5.77E-5,0.0397,1.24,17686,2453,1969,340]
["GO:0008285","negative regulation of cell proliferation",7.89e-05,0.0517,1.51,17686,630,1949,105]
["GO:0048812","neuron projection morphogenesis",8.11e-05,0.0508,1.98,17686,179,1998,40]
["GO:0050789","regulation of biological process",8.47e-05,0.0508,1.08,17686,10226,1974,1234]
["GO:0002460","adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains",8.61e-05,0.0495,12.41,17686,57,150,6]
["GO:0065007","biological regulation",9.13e-05,0.0503,1.07,17686,10739,2021,1319]
["GO:0048518","positive regulation of biological process",9.72e-05,0.0515,1.15,17686,5130,2015,671]
["GO:0010646","regulation of cell communication",1.05E-4,0.0535,1.22,17686,2830,1969,384]
["GO:0007166","cell surface receptor signaling pathway",1.05E-4,0.0519,1.25,17686,2158,2007,307]
["GO:0030036","actin cytoskeleton organization",1.11E-4,0.0525,1.94,17686,271,1444,43]
["GO:0032989","cellular component morphogenesis",1.15E-4,0.053,1.59,17686,452,1998,81]
["GO:0048522","positive regulation of cellular process",1.2E-4,0.0531,1.16,17686,4445,2015,588]
["GO:0006266","DNA ligation",1.26E-4,0.0543,12.48,17686,11,644,5]
["GO:0071805","potassium ion transmembrane transport",1.36E-4,0.0568,4.5,17686,140,309,11]
["GO:0071804","cellular potassium ion transport",1.36E-4,0.0551,4.5,17686,140,309,11]
["GO:0031342","negative regulation of cell killing",0.000139,0.0546,52.02,17686,15,68,3]
["GO:0048519","negative regulation of biological process",0.000143,0.0548,1.16,17686,4276,2015,567]
["GO:0045927","positive regulation of growth",0.000153,0.0571,2.32,17686,229,932,28]
["GO:0045893","positive regulation of transcription, DNA-templated",1.56E-4,0.0567,1.32,17686,1411,1970,207]
["GO:1903508","positive regulation of nucleic acid-templated transcription",1.56E-4,0.0552,1.32,17686,1411,1970,207]
["GO:0009950","dorsal/ventral axis specification",0.000158,0.0543,6.55,17686,13,1455,7]
["GO:0051960","regulation of nervous system development",0.00016,0.0536,1.46,17686,676,2021,113]
["GO:2000027","regulation of organ morphogenesis",0.000167,0.0549,2.04,17686,156,1892,34]
["GO:0007268","synaptic transmission",0.000168,0.0538,1.57,17686,475,1973,83]
["GO:0048706","embryonic skeletal system development",0.000172,0.0539,4.94,17686,36,995,10]
["GO:0051094","positive regulation of developmental process",1.95E-4,0.0596,1.36,17686,1091,2021,169]
["GO:0009887","organ morphogenesis",0.000206,0.0616,1.57,17686,447,2019,80]
["GO:0060333","interferon-gamma-mediated signaling pathway",0.00022,0.0644,4.71,17686,73,566,11]
["GO:0050870","positive regulation of T cell activation",0.000245,0.0703,3.27,17686,185,438,15]
["GO:0006813","potassium ion transport",0.000253,0.0711,5.14,17686,151,205,9]
["GO:0010870","positive regulation of receptor biosynthetic process",0.000258,0.0712,184.23,17686,12,16,2]
["GO:1902680","positive regulation of RNA biosynthetic process",0.00026,0.0701,1.3,17686,1438,1970,209]
["GO:1903522","regulation of blood circulation",0.000279,0.074,2.09,17686,225,1203,32]
["GO:0034765","regulation of ion transmembrane transport",0.000304,0.0791,1.88,17686,361,1120,43]
["GO:0090287","regulation of cellular response to growth factor stimulus",0.000307,0.0784,2.22,17686,232,961,28]
["GO:0060768","regulation of epithelial cell proliferation involved in prostate gland development",0.000314,0.0785,9.78,17686,10,904,5]
["GO:0048523","negative regulation of cellular process",0.000318,0.0781,1.17,17686,3950,1972,514]
["GO:0034112","positive regulation of homotypic cell-cell adhesion",0.000324,0.0784,3.2,17686,189,438,15]
["GO:1903039","positive regulation of leukocyte cell-cell adhesion",0.000336,0.0798,3.19,17686,190,438,15]
["GO:0002250","adaptive immune response",0.000338,0.079,5.68,17686,166,150,8]
["GO:0007638","mechanosensory behavior",0.000383,0.088,5.45,17686,12,1892,7]
["GO:0045597","positive regulation of cell differentiation",0.00039,0.088,1.4,17686,788,2015,126]
["GO:0034762","regulation of transmembrane transport",0.000403,0.0895,1.84,17686,377,1120,44]
["GO:0031223","auditory behavior",0.000409,0.0894,6.23,17686,9,1892,6]
["GO:0090031","positive regulation of steroid hormone biosynthetic process",0.000421,0.0906,9.04,17686,4,1956,4]
["GO:0051254","positive regulation of RNA metabolic process",0.000438,0.0929,1.29,17686,1475,1970,212]
["GO:0010563","negative regulation of phosphorus metabolic process",0.00045,0.0939,1.52,17686,503,1921,83]
["GO:0045936","negative regulation of phosphate metabolic process",0.00045,0.0925,1.52,17686,503,1921,83]
["GO:0042326","negative regulation of phosphorylation",0.000451,0.0913,1.59,17686,380,1956,67]
["GO:0050793","regulation of developmental process",0.000461,0.092,1.24,17686,2019,2021,286]
["GO:0016055","Wnt signaling pathway",0.000481,0.0948,1.74,17686,238,2007,47]
["GO:0060073","micturition",0.000507,0.0984,59.15,17686,2,299,2]
["GO:0086013","membrane repolarization during cardiac muscle cell action potential",0.000511,0.0977,5.98,17686,9,1973,6]
["GO:0048583","regulation of response to stimulus",0.000518,0.0977,1.18,17686,3396,1957,443]
["GO:0050794","regulation of cellular process",0.000539,0.1,1.08,17686,9727,2021,1197]
["GO:0048562","embryonic organ morphogenesis",0.000541,0.0993,2.16,17686,123,1931,29]
["GO:0048598","embryonic morphogenesis",0.000541,0.0981,1.56,17686,405,2019,72]
[]
["SOM Table 19. Significantly enriched molecular process gene ontology (GO) categories identified in the LH vs. MI comparison. Molecular process GO categories showing significant enrichment were identified by performing ranked-list gene ontology  analysis using GOrilla. Benjamini-Hochberg q-values were calculated to correct for the number of GO categories assessed. Enrichment is defined as (b/n) / (B/N), where N is the total number of genes in the input list, B is the total number associated with a particular GO term, n is the number of genes in the top of the ranked input list, b is the number of genes in the top of the ranked input list associated with a particular GO term."]

{"sheet":"SOM Table 20","index":19,"n_rows":10,"n_cols":9,"rows_kept":10,"merged":[[9,0,9,8]]}
["GO Term","Description","p-value","q-value","Enrichment","N","B","n2","b3"]
["GO:0005515","protein binding",3.23E-6,0.0137,1.09,17686,10184,1970,1241]
["GO:0019899","enzyme binding",1.72e-05,0.0366,1.37,17686,1621,1617,203]
["GO:0015197","peptide transporter activity",4.24e-05,0.06,8.78,17686,8,1511,6]
["GO:0005488","binding",6.92e-05,0.0735,1.05,17686,13465,1970,1578]
["GO:0022843","voltage-gated cation channel activity",7.07e-05,0.0601,2.19,17686,149,1736,32]
["GO:0022832","voltage-gated channel activity",9.89e-05,0.07,2.04,17686,185,1736,37]
["GO:0005244","voltage-gated ion channel activity",9.89e-05,0.06,2.04,17686,185,1736,37]
[]
["SOM Table 20. Significantly enriched biological function gene ontology (GO) categories identified in the LH vs. MI comparison. Biological function GO categories showing significant enrichment were identified by performing ranked-list gene ontology  analysis using GOrilla. Benjamini-Hochberg q-values were calculated to correct for the number of GO categories assessed. Enrichment is defined as (b/n) / (B/N), where N is the total number of genes in the input list, B is the total number associated with a particular GO term, n is the number of genes in the top of the ranked input list, b is the number of genes in the top of the ranked input list associated with a particular GO term."]

{"sheet":"SOM Table 21","index":20,"n_rows":9,"n_cols":9,"rows_kept":9,"merged":[[8,0,8,8]]}
["GO Term","Description","p-value","q-value","Enrichment","N","B","n2","b3"]
["GO:0098797","plasma membrane protein complex",2.08e-05,0.0344,1.62,17686,499,1973,90]
["GO:0042995","cell projection",4.79e-05,0.0395,1.34,17686,1330,2017,204]
["GO:0097458","neuron part",0.00014,0.0772,1.35,17686,1170,2005,179]
["GO:0042825","TAP complex",2.05E-4,0.0844,21.16,17686,3,836,3]
["GO:0042613","MHC class II protein complex",0.000286,0.0944,11.16,17686,14,566,5]
["GO:0034703","cation channel complex",0.000316,0.0868,2.01,17686,168,1732,33]
[]
["SOM Table 21. Significantly enriched cellular component gene ontology (GO) categories identified in the LH vs. MI comparison. Cellular component GO categories showing significant enrichment were identified by performing ranked-list gene ontology  analysis using GOrilla. Benjamini-Hochberg q-values were calculated to correct for the number of GO categories assessed. Enrichment is defined as (b/n) / (B/N), where N is the total number of genes in the input list, B is the total number associated with a particular GO term, n is the number of genes in the top of the ranked input list, b is the number of genes in the top of the ranked input list associated with a particular GO term."]

{"sheet":"SOM Table 22","index":21,"n_rows":10,"n_cols":3,"rows_kept":10,"merged":[[9,0,9,2]]}
["Catalogue no.","Gene","Manufacturer"]
["ge-DD-6","ATP5B","Primerdesign"]
["ge-DD-7","UBC","Primerdesign"]
["ge-DD-8","TBP","Primerdesign"]
["ge-DD-9","NCBP2","Primerdesign"]
["ge-DD-10","GAPDH","Primerdesign"]
["ge-DD-11","CYC1","Primerdesign"]
["4333761T","RPLP0","Applied Biosystems by Thermo Fisher Scientific"]
[]
["Supplementary Table 22. Details of the qRT-PCR assays used to measure the seven reference genes assessed for the stability of their expression using geNorm (Vandesompele et al., 2002)."]