{"text_format":"3","workbook":"xlsx","n_sheets":12,"sheets":["S1","S2","S3","S4","S5","S6","S7","S8","S9","S10","S11","S12"],"not_rendered":{"defined_names":1},"read":"whole","date_system":"1900"}

{"sheet":"S1","index":0,"n_rows":69,"n_cols":38,"rows_kept":69,"merged":[[1,15,1,20],[1,21,1,29],[1,30,1,36],[3,5,4,5],[3,7,4,7],[5,5,6,5],[5,7,6,7],[29,5,30,5],[29,7,30,7]]}
["Table S1: Patients clinical information"]
[{"$nulls":15},"Cardinal BWSp features",{"$nulls":5},"Suggestive BWSp features",{"$nulls":8},"Additional features"]
["Patient code","Publications","MLID (MS-MLPA test)","Clinical affected DMRs","MLID (Methylation array)","Maternal-effect gene variant (mother)","Zygotic factor variant (patient)","Miscarriages","Male/Female","Age at sampling * ","Maternal age at pregnancy","Gestational age ","ART","Twinning ","Clinical score"," Macroglossia ","Lateralised overgrowth "," Exomphalos ","Multifocal and/or bilateral Wilms tumour or nephroblastomatosis","Hyperinsulinism ","Adrenal cortex cytomegaly, placental mesenchymal dysplasia or pancreatic adenomatosis ","Birthweight >2SDS above the mean "," Polyhydramnios and/or placentomegaly "," Umbilical hernia","Diastasis recti","Nephromegaly and/or Hepatomegaly ","Hypoglycaemia "," Ear creases and/or pits "," Facial naevus simplex","Typical BWSp tumours (neuroblastoma, rhabdomyosarcoma, unilateral Wilms tumour, hepatoblastoma, adrenocortical carcinoma or phaeochromocytoma) ","Facial asymmetry"," Facies grossolana"," Cleft palate","Cardiomyopathies/cardiac defects","Seizures","Mental delay/Neurodevelopmental delay ","Other neoplasms ","Others"]
["P1","Sparago et al.2019, Clinical Epigenetics (III-1)","MLID","PLAGL1, MEST, KCNQ1OT1, MEG3, SNURF, GNAS","C3","NLRP5","-",4,"M","18 years ","31 years","39w","-",null,9,"P","P",{"$nulls":4},"*","P","P",null,null,"P","P","P",{"$nulls":6},"P",null,"*Small for Gestational Age. Cryptorchidism, hypocalcemia, facial dysmorphism, feeding difficulties, apnea, hyperopia"]
["P2 (P1 Brother)","Sparago et al.2019, Clinical Epigenetics (III-2)","MLID","GRB10, MEST, H19/IGF2, KCNQ1OT1, GNAS","C3",null,"-",null,"M","10 years","40 years","36w","-",null,1,{"$nulls":7},"P",{"$nulls":7},"P",{"$nulls":6},"Apnea"]
["P3","Cubellis et al. 2020, Clinical Epigenetics (family 1, III-1)","MLID","KCNQ1OT1, SNURF, PEG3, GNAS","C3","PADI6","-",0,"F","4 years","31 years","32w+4d","-",null,10,"P","P",{"$nulls":3},"P",null,"P","P","P",null,"P",null,"P",{"$nulls":4},"P",{"$nulls":3},"Preeclampsia, strabismus, feeding difficulties, macrostomia, apnea, hemangioma"]
["P4 (P3 Sister)","Cubellis et al. 2020, Clinical Epigenetics (family 1, III-2)","MLID","KCNQ1OT1, MEG3","C3",null,"-",null,"F","1 year","34 years","39w","-",null,8,"P",{"$nulls":4},"P",null,"P","P",null,null,"P",null,"P",{"$nulls":4},"P",{"$nulls":3},"Hemangioma"]
["P5","Cubellis et al. 2020, Clinical Epigenetics (family 2)","MLID","KCNQ1OT1, GNAS","C3","PADI6","NA",1,"F","30 years","35 years","30w","-",null,8,"P","P",{"$nulls":6},"P","P","P",null,"P","P",null,null,"P",{"$nulls":5},"Facial dysmorphism"]
["P6","Cubellis et al. 2020, Clinical Epigenetics (family 3)","MLID","MEST, KCNQ1OT1, GNAS","C3","PADI6","NA",0,"M","18 years","-","38w","-",null,5,"P","P",{"$nulls":4},"P",{"$nulls":9},"P",null,"P","P",null,null,"Cryptorchidism, mandibular prognathia, Arnold-Chiari I malformation\nwas diagnosed."]
["P7",null,"MLID","PLAGL1, KCNQ1OT1","C3","NA","-",0,"M","9 months","37 years","36w","-",null,5,"P",{"$nulls":6},"P","P","P",null,null,"P",{"$nulls":9},"Macrostomia, mandibular prognathia"]
["P8","Bliek et al. 2009, EJHG (IC2-BWS2)","MLID","PLAGL1, MEST, KCNQ1OT1, GNAS","C3","-","-","1 miscarriage + 1 stillborn","M","4 years","35 years","37w","-",null,9,"P","P",{"$nulls":7},"P","P","P","P","P",null,null,"P",{"$nulls":5},"Cryptorchidism, hypothyroidism"]
["P9","Pignata et al.2022, Clinical Epigenetics  (BWS2)","MLID","GRB10, KCNQ1OT1","C3","PADI6","NA","2 miscarriages + 1 stillborn","F","39 years","36 years","33w","-",null,8,"P",{"$nulls":6},"P",null,"P","P","P","P","P",null,"P","P",{"$nulls":3},"P",null,"Enlarged pancreas, feeding difficulties, hearing impairment, mild arachnodactyly of hands, hypoplasia of the maxilla, ureteric anomalies"]
["P10",null,"MLID","KCNQ1OT1, GNAS","C3","-","-",0,"F","16 years","36 years","36w","-",null,10,"P",null,"P",{"$nulls":3},"P","P",null,"P","P","P","P",{"$nulls":3},"P",{"$nulls":5},"Macrostomia,intestinal malrotation, pyloric stenosis surgery, mandibular prognathia"]
["P11",null,"MLID","MEST, KCNQ1OT1, GNAS","C3","-","-",0,"M","2 months","32 years","36w + 2d","-",null,7,"P",null,"P",{"$nulls":3},"P","P",{"$nulls":5},"P",null,null,"P",{"$nulls":5},"Feeding difficulties, macrostomia, mandibular prognathia, hypoplasia of the maxilla, prominent occiput"]
["P12","Bliek et al. 2009, EJHG (IC2-BWS3); Pignata et al.2022, Clinical Epigenetics (BWS1)","MLID","GRB10, MEST, KCNQ1OT1","C3","KHDC3L","NA",0,"F","24 years","25 years","36w","-",null,8,"P",{"$nulls":5},"P",null,"P",null,"P","P","P","P",null,null,"P",null,null,"P","P",null,"Feeding difficulties, mandibular prognathia, hypoplasia of the maxilla, hearing impairment, myopia, preeclampsia, strabismus"]
["P13","Bliek et al. 2009, EJHG(IC2-BWS1)","MLID","PLAGL1, MEST, KCNQ1OT1","C3","NA","-",0,"M","2 months","-","40w","P","P",4,"P",{"$nulls":7},"P","P",{"$nulls":3},"P",null,null,"P",{"$nulls":5},"*ovarian hyperstimulation. \nSkin marbling, macrostomia, hypoplasia of the maxilla, prominent occiput, proptosis, apnea (perinatal), inguinal hernia "]
["P14","Pignata et al.2022, Clinical Epigenetics (BWS3)","MLID","GRB10, KCNQ1OT1","C3","NLRP5, NLRP4","NA","4 miscarriages + 2 stillborns","F","30 years","25 years","-","P",null,5,"P","P",{"$nulls":4},"P",{"$nulls":13},"P",null,"*Ovarian hyperstimulation; Hypoplasia of the maxilla, infantile muscular hypotonia, scoliosis, strabismus, some episodes of cyanosis"]
["P15","Bliek et al. 2009, EJHG (IC2-BWS4)","MLID","PLAGL1, MEST, KCNQ1OT1, GNAS","C3","-","-",0,"M","5 months","-","-","-",null,3,"P",{"$nulls":5},"P"]
["P16",null,"MLID","PLAGL1, GRB10, KCNQ1OT1, MEG3, GNAS","C3","-","NA",1,"F","5 years","33 years","37w + 3d","-",null,7,"P","P",{"$nulls":6},"P",{"$nulls":3},"P","P",{"$nulls":8},"Prominent occiput"]
["P17","Pignata et al.2022, Clinical Epigenetics (family 4)","MLID","PLAGL1, KCNQ1OT1","C3","NLRP5","NA",0,"M","15 years",null,"-","P",null,6,"P","P",{"$nulls":4},"P",{"$nulls":4},"P",{"$nulls":10},"Atopic eczema, gestational diabetes"]
["P18","Pignata et al.2022, Clinical Epigenetics (family 6)","MLID","MEST, KCNQ1OT1, GNAS","C3","NLRP2","-",0,"F","14 years","37 years","-","-",null,7,"P",null,"P",{"$nulls":3},"P",{"$nulls":4},"P","P",{"$nulls":9},"Nevus flammeus (neck), round face, haemangioma"]
["P19",null,"non-MLID","KCNQ1OT1","C2","-","NA",2,"M","4 years","33 years","-","-","P",6,null,"P",{"$nulls":4},"P",null,"P","P",null,"P",null,"P",null,"P",{"$nulls":4},"P",null," Large forehead and broad facial features"]
["P20",null,"non-MLID","KCNQ1OT1","C2","-","NA",0,"F","1 year","29 years","-","-","P",4,"P","P"]
["P21","Pignata et al.2022, Clinical Epigenetics (family 5)","MLID","KCNQ1OT1, GNAS","C3","NLRP2","NA",1,"F","22 years",null,"-","-",null,6,"P",{"$nulls":3},"P",{"$nulls":5},"P","P",{"$nulls":10},"Hypoplasia of the maxilla, nevus flammeus (head, neck), neonatal anaemia, respiratory distress, round face"]
["P22",null,"non-MLID","KCNQ1OT1","C2","-","NA",0,"M","1 year","30 years ","-","P",null,6,"P",null,"P",{"$nulls":4},"P",null,null,"P",{"$nulls":7},"P",{"$nulls":3},"Ventricular hypertrophy, hypospadias, patent ductus arteriosus "]
["P23",null,"non-MLID","KCNQ1OT1","C3","-","NA",0,"F","1 year","32 years ","-","-",null,5,"P",{"$nulls":7},"P","P",null,"P",null,"P"]
["P24",null,"non-MLID","KCNQ1OT1","C2","NA","NA",0,"M","4 months ","42 years","-","P",null,5,"P",{"$nulls":10},"P","P","P",null,"P",{"$nulls":4},"P"]
["P25",null,"MLID","PLAGL1, KCNQ1OT1","C3","NA","NA",0,"M","1 year","39 years ","-","P"]
["P26",null,"MLID","PLAGL1, GRB10, KCNQ1OT1, GNAS","C3","NA","NA","NA","F","6 years","26 years","-","P","P",5,"P",null,"P",{"$nulls":3},"P",{"$nulls":15},"Triplets"]
["P27",null,"non-MLID","KCNQ1OT1","C2","NA","NA",0,"F","6 months","29 years","28w + 6d","-","P",8,"P",{"$nulls":5},"P",null,"P",null,null,"P","P","P","P",{"$nulls":7},"Feeding difficulties,macrostomia, camptodactyly, hemangioma"]
["P28",null,"non-MLID","KCNQ1OT1","C2",null,"NA",null,"F","6 months","29 years","28w + 6d","-","P",1,{"$nulls":13},"P",{"$nulls":8},"Camptodactyly, hemangioma"]
["P29","Cecere et al. 2023, Cancers ","non-MLID","KCNQ1OT1","C2","NA","-",0,"F","15 years","24 years","-","-",null,3,null,"P",{"$nulls":10},"P",{"$nulls":8},"P","Colorectal cancer"]
["P30",null,"MLID","PLAGL1, KCNQ1OT1","C3","-","-",0,"M","4 months","-","-","-",null,5,"P",{"$nulls":6},"P",null,null,"P",null,"P",{"$nulls":9},"Mandibular prognathia, prominent occiput"]
["P31 ",null,"MLID","KCNQ1OT1, GNAS","C3","-","-",0,"M","-","-","37w","-",null,8,"P",{"$nulls":5},"P",null,"P",null,"P","P","P","P",null,null,"P",null,"P","P","P",null,"Corpus callosum agenesis, pre-eclampsia, facial dysmorphism, neonatal respiratory distress, hyperbilirubinemia, early bone age"]
["P32",null,"non-MLID","KCNQ1OT1","C2","-","NA",0,"M","1 month ","27 years","-","-",null,8,"P","P","P",{"$nulls":5},"P","P",null,"P",{"$nulls":4},"P",{"$nulls":5},"Macrostomia, hemangioma, bilateral renal pelvis dilatation"]
["P33",null,"non-MLID","KCNQ1OT1","C2","-","NA",1,"M","3 years","32 years","40w","-",null,7,"P","P",{"$nulls":9},"P","P","P",null,null,"P",{"$nulls":3},"P",null,"Hemangioma"]
["P34",null,"non-MLID","KCNQ1OT1","C2","-","NA",0,"M","2 years","33 years","37w","-","P",6,"P",null,"P",{"$nulls":5},"P",null,null,"P",{"$nulls":3},"P","P",null,"P",{"$nulls":3},"Inguinal hernia "]
["P35",null,"non-MLID","KCNQ1OT1","C2","-","NA",2,"F","-","-","41w","-",null,3,"P",{"$nulls":12},"P",{"$nulls":8},"Type I diabetes"]
["P36",null,"non-MLID","KCNQ1OT1","C2","-","NA",0,"M","-","-","38w","-",null,11,"P","P","P",{"$nulls":3},"P","P",null,null,"P","P","P",null,null,"P","P",{"$nulls":5},"Cryptorchidism"]
["P37",null,"non-MLID","KCNQ1OT1","C2","-","NA",0,"F","3 months","40 years","36w","-",null,7,"P",{"$nulls":6},"P","P","P",null,"P","P","P",{"$nulls":4},"P",{"$nulls":3},"Apnea, cyanosis, macrostomia, hypoplasia of the maxilla, prominent occiput, batrachian abdomen, mottled skin"]
["P38",null,"non-MLID","KCNQ1OT1","C2","-","NA",0,"M","-","23 years","-","-",null,8,"P",null,"P",{"$nulls":4},"P",null,null,"P","P","P",{"$nulls":4},"P","P",{"$nulls":3},"Hypoplasia of the maxilla, prominent occiput"]
["P39",null,"non-MLID","KCNQ1OT1","C2","-","NA","1 miscarriage + 1 stillborn","F","1 year","21 years","38w","-",null,7,"P",null,"P",{"$nulls":3},"P",{"$nulls":5},"P","P",null,null,"P",null,"P"]
["P40",null,"non-MLID","KCNQ1OT1","C2","-","NA",0,"F","1 year","-","-","-",null,6,"P",{"$nulls":5},"P",null,"P","P",null,null,"P","P",null,"P",{"$nulls":6},"Macrostomia, hypoplasia of the maxilla, hemangioma"]
["P41",null,"non-MLID","KCNQ1OT1","C2","NA","NA",0,"F","-","37 years","37w + 6d","-",null,5,"P",{"$nulls":7},"P","P",null,null,"P","P",{"$nulls":4},"P",{"$nulls":3},"Macrostomia,  hypoplasia of the maxilla, prominent occiput"]
["P42",null,"non-MLID","KCNQ1OT1","C2","NA","NA",0,"F","-","-","39w","-",null,6,"P",{"$nulls":5},"P",null,"P","P",null,null,"P","P",{"$nulls":8},"Prominent occiput"]
["P43",null,"non-MLID","KCNQ1OT1","C2","NA","NA",0,"M","-","36 years","38w","-",null,6,"P",{"$nulls":5},"P","P","P",{"$nulls":3},"P",{"$nulls":3},"P",{"$nulls":5},"Macrostomia, angiomas, hypoplasia of the maxilla, prominent occiput"]
["P44",null,"non-MLID","KCNQ1OT1","C2","NA","NA",0,"M","10 months","34 years","36w","-",null,8,"P","P",{"$nulls":4},"P",{"$nulls":3},"P","P","P",{"$nulls":9},"Macrostomia"]
["P45",null,"non-MLID","KCNQ1OT1","C2","NA","NA",0,"F","36 years","35 years","-","-",null,6,"P","P",{"$nulls":8},"P",null,"P",{"$nulls":6},"P",null,null," Cyanosis, macrostomia, genital anomalies"]
["P46",null,"non-MLID","KCNQ1OT1","C2","NA","NA",0,"F","3 months","-","37w","-",null,4,"P",{"$nulls":5},"P",null,"P"]
["P47",null,"non-MLID","KCNQ1OT1","C2","NA","NA",0,"F","8 months","-","-","-",null,7,"P",null,"P",{"$nulls":4},"P",{"$nulls":3},"P","P",{"$nulls":3},"P",null,"P"]
["P48",null,"non-MLID","KCNQ1OT1","C2","NA","NA",0,"M","20 years","-","40w","-",null,7,"P","P",{"$nulls":6},"P","P","P",null,null,"P",{"$nulls":8},"Neonatal jaundice, hypotonia"]
["P49",null,"non-MLID","KCNQ1OT1","C2","NA","NA",0,"F","13 years","32 years","38w","-",null,7,"P","P",{"$nulls":5},"P",null,null,"P",null,null,"P",{"$nulls":8},"Hemangioma"]
["P50",null,"non-MLID","KCNQ1OT1","C2","NA","NA","NA","M","NA","NA","-","-",null,"NA"]
["P51",null,"non-MLID","KCNQ1OT1","C2","NA","NA",0,"F","11 years","24 years","40w","-",null,6,"P","P",{"$nulls":6},"P",{"$nulls":4},"P"]
["P52",null,"MLID","KCNQ1OT1, GNAS","C3","PADI6","NA",0,"F","8 months","-","36w","-",null,9,"P","P","P",{"$nulls":7},"P",null,"P","P",null,null,"P"]
["P53","Bliek et al. 2009, EJHG  (IC2-BWS5)","MLID","KCNQ1OT1, GNAS","C3","NA","NA",0,"F","9 months","-","-","-",null,6,"P",{"$nulls":8},"P","P","P","P",null,null,"P","P"]
["P54",null,"non-MLID","KCNQ1OT1","C2","-","NA",0,"F","-","-","36w","-",null,11,"P","P","P",{"$nulls":5},"P",null,"P","P","P","P",null,null,"P","P",null,null,"P",null,"Consanguinity, joint hypermobility, hypocalcemia, ureteric anomalies "]
["P55",null,"non-MLID","KCNQ1OT1","C2","-","NA",0,"F","30 years","-","-","-",null,3,null,null,"P",{"$nulls":3},"P"]
["P56",null,"non-MLID","KCNQ1OT1","C3","-","NA",0,"M","6 months","41 years","35w + 2d","-",null,6,"P","P",{"$nulls":10},"P","P",null,null,"P",null,"P",{"$nulls":3},"Hemangioma, neonatal hypotonia"]
["P57",null,"non-MLID","KCNQ1OT1","C2","NA","NA",0,"F","19 months","28 years","38w","P",null,6,"P","P",{"$nulls":8},"P",null,"P",{"$nulls":3},"P",{"$nulls":5},"Mandibular prognathia, macrostomia"]
["P58",null,"non-MLID","KCNQ1OT1","C3","NA","NA",0,"M","10 months","34 years","-","-",null,8,"P","P","P",{"$nulls":9},"P","P",{"$nulls":3},"P","P",{"$nulls":3},"Apnea, macrostomia,cryptorchidism, hypospadias, hypoplasia of the maxilla, prominent occiput"]
["P59",null,"non-MLID","KCNQ1OT1","C2","NA","NA",0,"F","-","-","-","-",null,7,"P",null,"P",{"$nulls":6},"P",null,"P","P",{"$nulls":9},"Intestinal malrotation, feeding difficulties, apnea"]
["P60",null,"non-MLID","KCNQ1OT1","C3","-","NA",0,"M","-","-","39w","-",null,11,"P","P","P",{"$nulls":5},"P","P","P","P","P","P",null,null,"P",null,"P","P","P",null,"Hemangioma"]
["P61",null,"non-MLID","KCNQ1OT1","C2","NA","NA",0,"M","-","33 years","-","-",null,6,"P",null,"P",{"$nulls":6},"P",null,"P",{"$nulls":10},"Cryptorchidism"]
["P62",null,"non-MLID","KCNQ1OT1","C2","NA","NA",0,"F","-","31 years","33w + 1d","-",null,8,"P","P",{"$nulls":5},"P",null,"P",null,null,"P","P",{"$nulls":3},"P","P",{"$nulls":3},"Macrostomia,  mandibular prognathia, feedng difficulties, hypoplasia of he maxilla, prominent occiput "]
["P63",null,"non-MLID","KCNQ1OT1","C2","NA","NA",0,"F","12 years","-","37w","-",null,8,"P","P","P",{"$nulls":6},"P",null,null,"P",{"$nulls":9},"Macrostomia, genital anomalies"]
["P64",null,"non-MLID","KCNQ1OT1","C2","NA","NA",0,"F","2 months","30 years ","40w + 2d","-",null,3,"P",{"$nulls":12},"P",{"$nulls":8},"Prominent occiput, genital anomalies"]
[]
[null,"* Sampling and clinical phenotype collection were performed on the same day"]

{"sheet":"S2","index":1,"n_rows":106,"n_cols":7,"rows_kept":106}
["Table S2. BWS and Control samples"]
["Sample_Name","Gender","Tissue","Sample_Group","Batch","Age_range","Age"]
["C1","M","Blood","Control","A","B",17]
["C2","M","Blood","Control","A","B",16]
["C3","F","Blood","Control","A","D",32]
["C4","F","Blood","Control","A","C",25]
["C5","M","Blood","Control","A","B",15]
["C6","F","Blood","Control","A","B",15]
["C7","F","Blood","Control","B","D",40]
["C8","F","Blood","Control","B","C",30]
["C9","F","Blood","Control","B","A",5]
["C10","M","Blood","Control","B","A",5]
["C11","F","Blood","Control","B","A",5]
["C12","M","Blood","Control","B","A",5]
["C13","F","Blood","Control","C","A",5]
["C14","M","Blood","Control","C","A",5]
["C15 (C10 technical rep)","M","Blood","Control","C","A",5]
["C16 (C11 technical rep)","F","Blood","Control","C","A",5]
["C17","M","Blood","Control","D","A",2]
["C18","M","Blood","Control","D","A",2]
["C19","F","Blood","Control","D","A",10]
["C20","F","Blood","Control","D","B",13]
["C21","F","Blood","Control","D","B",14]
["C22","M","Blood","Control","D","B",13]
["C23","F","Blood","Control","D","D",32]
["C24","F","Blood","Control","D","A",2]
["C25","M","Blood","Control","E","B",18]
["C26","F","Blood","Control","E","B",15]
["C27","M","Blood","Control","E","A",8]
["C28","M","Blood","Control","E","A",2]
["C29","Unknown","Blood","Control","F","Unknown","Unknown"]
["C30 (C14 technical rep)","M","Blood","Control","F","A",5]
["C31","Unknown","Blood","Control","F","Unknown","Unknown"]
["C32","Unknown","Blood","Control","F","Unknown","Unknown"]
["C33","Unknown","Blood","Control","F","Unknown","Unknown"]
["C34","Unknown","Blood","Control","F","Unknown","Unknown"]
["C35","Unknown","Blood","Control","F","Unknown","Unknown"]
["C36","M","Blood","Control","G","Unknown","Unknown"]
["C37","Unknown","Blood","Control","G","Unknown","Unknown"]
["C38","M","Blood","Control","G","Unknown","Unknown"]
["C39","F","Blood","Control","G","Unknown","Unknown"]
["C40","Unknown","Blood","Control","G","Unknown","Unknown"]
["P1","M","Blood","Case","A","B",20]
["P2 (P1 Brother)","M","Blood","Case","A","B",11]
["P3","F","Blood","Case","B","A",4]
["P4 (P3 Sister)","F","Blood","Case","B","A",1]
["P5","F","Blood","Case","B","B",14]
["P6","M","Blood","Case","B","B",16]
["P7","M","Blood","Case","C","A",1]
["P8","M","Blood","Case","C","A",4]
["P9","F","Blood","Case","C","B",18]
["P10","F","Blood","Case","C","B",16]
["P11","M","Blood","Case","C","A",1]
["P12","F","Blood","Case","C","A",6]
["P13","M","Blood","Case","C","A",1]
["P14","F","Blood","Case","C","C",30]
["P15","M","Blood","Case","C","A",1]
["P16","F","Blood","Case","C","A",4]
["P17","M","Blood","Case","D","B",15]
["P18","F","Blood","Case","D","B",13]
["P19","Unknown","Blood","Case","D","Unknown",1]
["P20","Unknown","Blood","Case","D","Unknown",5]
["P21","F","Blood","Case","D","B",19]
["P22","Unknown","Blood","Case","D","Unknown",5]
["P23","Unknown","Blood","Case","D","Unknown",5]
["P24","Unknown","Blood","Case","D","Unknown",5]
["P25","Unknown","Blood","Case","D","Unknown",5]
["P26","Unknown","Blood","Case","D","Unknown",5]
["P27","F","Blood","Case","D","A",1]
["P28","F","Blood","Case","D","A",1]
["P29","F","Blood","Case","D","C",27]
["P30","M","Blood","Case","D","A",1]
["P31","M","Blood","Case","D","A",5]
["P32","M","Blood","Case","E","A",1]
["P33","M","Blood","Case","E","A",3]
["P34","M","Blood","Case","E","A",2]
["P35","F","Blood","Case","E","A",10]
["P36","M","Blood","Case","E","A",9]
["P37","F","Blood","Case","E","A",1]
["P38","M","Blood","Case","F","A",1]
["P39","F","Blood","Case","F","A",1]
["P40","F","Blood","Case","F","A",0.3]
["P41","F","Blood","Case","F","A",0.25]
["P42","F","Blood","Case","F","A",0.08]
["P43","M","Blood","Case","F","A",0.3]
["P44","M","Blood","Case","F","A",1]
["P45","F","Blood","Case","F","A",33]
["P46","F","Blood","Case","F","A",0.25]
["P47","F","Blood","Case","F","A",0.6]
["P48","M","Blood","Case","F","A",20]
["P49","F","Blood","Case","F","A",13]
["P50","M","Blood","Case","F","Unknown","Unknown"]
["P51","F","Blood","Case","F","A",11]
["P52","F","Blood","Case","F","A",1]
["P53","F","Blood","Case","G","A",0.75]
["P54","F","Blood","Case","G","Unknown","Unknown"]
["P55","F","Blood","Case","G","C",30]
["P56","M","Blood","Case","G","A",0.5]
["P57","F","Blood","Case","G","A",1.58]
["P58","M","Blood","Case","G","A",0.8]
["P59","F","Blood","Case","G","Unknown","Unknown"]
["P60","M","Blood","Case","G","Unknown","Unknown"]
["P61","M","Blood","Case","G","Unknown","Unknown"]
["P62","F","Blood","Case","G","Unknown","Unknown"]
["P63","F","Blood","Case","G","A",12]
["P64","F","Blood","Case","G","A",0.16]

{"sheet":"S3","index":2,"n_rows":52,"n_cols":9,"rows_kept":52}
["Table S3. iDMR coordinates and entropy"]
["iDMR","Shannon","chrom","start","end","germ","NarrayProbes","covered","iDMRs included in the analysis reported in Fig.1"]
["FANCC:Int1-DMR","NA","chr9",98075400,98075744,"Oocyte_gDMR",1,1]
["GPR1-AS:TSS-DMR","NA","chr2",207066967,207069445,"Oocyte_gDMR",3,2]
["IGF2:alt-TSS-DMR","NA","chr11",2168333,2169768,"Sperm_gDMR",2,2]
["IGF2R:Int2-DMR","NA","chr6",160426558,160427561,"Oocyte_gDMR",2,2]
["MEG3/DLK1:IG-DMR","NA","chr14",101275427,101278058,"Sperm_gDMR",2,2]
["MEG8:Int2-DMR","NA","chr14",101370741,101371419,"secondary_DMR",1,1]
["PPIEL:Ex1-DMR","NA","chr1",40024626,40025540,"Oocyte_gDMR",4,3]
["SNRPN:Int1-DMR1","NA","chr15",25093008,25093829,"secondary_DMR",4,3]
["SVOPL:alt-TSS-DMR","NA","chr7",138348118,138349069,"Oocyte_gDMR",2,2]
["VTRNA2-1:DMR","NA","chr5",135414802,135416645,"Oocyte_gDMR",18,17]
["WDR27:Int13-DMR","NA","chr6",170054504,170055618,"Oocyte_gDMR",3,2]
["WRB:alt-TSS-DMR","NA","chr21",40757510,40758276,"Oocyte_gDMR",4,3]
["ZNF597:3-DMR","NA","chr16",3481801,3482388,"Oocyte_gDMR",3,3]
["SNRPN:Int1-DMR2",1.58777540057261,"chr15",25123027,25123905,"secondary_DMR",6,6]
["IGF1R:Int2-DMR",1.57452607636523,"chr15",99408496,99409650,"Oocyte_gDMR",7,7]
["ERLIN2:Int6-DMR",1.47751649911388,"chr8",37604992,37606088,"Oocyte_gDMR",7,7]
["DIRAS3:Ex2-DMR",1.45895392869927,"chr1",68512505,68513486,"Oocyte_gDMR",8,7]
["SNU13:alt-TSS-DMR",1.34115483539451,"chr22",42077774,42078873,"Oocyte_gDMR",8,8,"+"]
["NNAT:TSS-DMR",1.1172786489039,"chr20",36148604,36150528,"Oocyte_gDMR",37,36,"+"]
["KCNQ1OT1:TSS-DMR",0.999473020185984,"chr11",2719948,2722259,"Oocyte_gDMR",26,25,"+"]
["MEST:alt-TSS-DMR",0.969414207285718,"chr7",130130122,130134388,"Oocyte_gDMR",55,51,"+"]
["INPP5F:Int2-DMR",0.968607755591262,"chr10",121578046,121578727,"Oocyte_gDMR",6,6,"+"]
["GRB10:alt-TSS-DMR",0.956888665679821,"chr7",50848726,50851312,"Oocyte_gDMR",10,10,"+"]
["GNAS-A/B:TSS-DMR",0.956888665679821,"chr20",57463265,57465201,"secondary_DMR",40,39,"+"]
["PEG10:TSS-DMR",0.935269139868357,"chr7",94285537,94287960,"Oocyte_gDMR",51,51,"+"]
["H19/IGF2:IG-DMR",0.909022156087815,"chr11",2018812,2024740,"Sperm_gDMR",44,35,"+"]
["GNAS-AS1:TSS-DMR",0.909022156087815,"chr20",57425649,57428033,"Oocyte_gDMR",62,60,"+"]
["GNAS-XL:Ex1-DMR",0.877962001394391,"chr20",57428905,57431463,"Oocyte_gDMR",7,6,"+"]
["ZDBF2/GPR1:IG-DMR",0.842424024494,"chr2",207114583,207136544,"Sperm_gDMR-secondary_DMR",15,15]
["DIRAS3:TSS-DMR",0.800392208045336,"chr1",68515433,68517545,"Oocyte_gDMR",24,21,"+"]
["IGF2:Ex9-DMR",0.753197991069501,"chr11",2153991,2155112,"secondary_DMR",10,10]
["MKRN3:TSS-DMR",0.753197991069501,"chr15",23807086,23812495,"Oocyte_gDMR-secondary_DMR",17,13]
["SNRPN:alt-TSS-DMR",0.753197991069501,"chr15",25068564,25069481,"secondary_DMR",8,7]
["PLAGL1:alt-TSS-DMR",0.699772221773307,"chr6",144328078,144329888,"Oocyte_gDMR",17,15,"+"]
["MCTS2P:TSS-DMR",0.699772221773307,"chr20",30134663,30135933,"Oocyte_gDMR",8,8,"+"]
["RB1:Int2-DMR",0.639457132485164,"chr13",48892341,48895763,"Oocyte_gDMR",13,10,"+"]
["MAGEL2:TSS-DMR",0.639457132485164,"chr15",23892425,23894029,"secondary_DMR",9,9]
["ZNF597:TSS-DMR",0.571354974427955,"chr16",3492828,3494463,"secondary_DMR",16,14]
["FAM50B:TSS-DMR",0.494182934849789,"chr6",3849082,3850359,"Oocyte_gDMR",24,21,"+"]
["SNURF:TSS-DMR",0.494182934849789,"chr15",25200004,25201976,"Oocyte_gDMR",10,10,"+"]
["NAP1L5:TSS-DMR",0.480433457452962,"chr4",89618184,89619237,"Oocyte_gDMR",14,14,"+"]
["PEG13:TSS-DMR",0.405977038475571,"chr8",141108147,141111081,"Oocyte_gDMR",9,8,"+"]
["L3MBTL1:alt-TSS-DMR",0.405977038475571,"chr20",42142365,42144040,"Oocyte_gDMR",26,25,"+"]
["GNAS-NESP:TSS-DMR",0.405977038475571,"chr20",57414039,57418612,"secondary_DMR",26,25,"+"]
["HTR5A:TSS-DMR",0.303374836086414,"chr7",154862719,154863382,"Oocyte_gDMR",8,8,"+"]
["NDN:TSS-DMR",0.303374836086414,"chr15",23931451,23932759,"secondary_DMR",10,10]
["ZNF331:alt-TSS-DMR1",0.303374836086414,"chr19",54040510,54042212,"Oocyte_gDMR",18,13,"+"]
["MEG3:TSS-DMR",0.179256066928321,"chr14",101290524,101293978,"secondary_DMR",35,35,"+"]
["PEG3:TSS-DMR",0.179256066928321,"chr19",57348493,57353271,"Oocyte_gDMR",36,34]
["ZNF331:alt-TSS-DMR2",0,"chr19",54057086,54058425,"Oocyte_gDMR",13,7,"+"]

{"sheet":"S4","index":3,"n_rows":103,"n_cols":52,"rows_kept":103}
["Table S4.  Methylation values of all iDMRs analysed by Epic array"]
[null,"Cluster          (Methylation array)","PPIEL:Ex1-DMR","DIRAS3:Ex2-DMR","DIRAS3:TSS-DMR","GPR1-AS:TSS-DMR","ZDBF2/GPR1:IG-DMR","NAP1L5:TSS-DMR","VTRNA2-1:DMR","FAM50B:TSS-DMR","PLAGL1:alt-TSS-DMR","IGF2R:Int2-DMR","WDR27:Int13-DMR","GRB10:alt-TSS-DMR","PEG10:TSS-DMR","MEST:alt-TSS-DMR","SVOPL:alt-TSS-DMR","HTR5A:TSS-DMR","ERLIN2:Int6-DMR","PEG13:TSS-DMR","FANCC:Int1-DMR","INPP5F:Int2-DMR","H19/IGF2:IG-DMR","IGF2:Ex9-DMR","IGF2:alt-TSS-DMR","KCNQ1OT1:TSS-DMR","RB1:Int2-DMR","MEG3/DLK1:IG-DMR","MEG3:TSS-DMR","MEG8:Int2-DMR","MKRN3:TSS-DMR","MAGEL2:TSS-DMR","NDN:TSS-DMR","SNRPN:alt-TSS-DMR","SNRPN:Int1-DMR1","SNRPN:Int1-DMR2","SNURF:TSS-DMR","IGF1R:Int2-DMR","ZNF597:3-DMR","ZNF597:TSS-DMR","ZNF331:alt-TSS-DMR1","ZNF331:alt-TSS-DMR2","PEG3:TSS-DMR","MCTS2P:TSS-DMR","NNAT:TSS-DMR","L3MBTL1:alt-TSS-DMR","GNAS-NESP:TSS-DMR","GNAS-AS1:TSS-DMR","GNAS-XL:Ex1-DMR","GNAS-A/B:TSS-DMR","WRB:alt-TSS-DMR","SNU13:alt-TSS-DMR"]
["C1",null,0.556362389282352,0.522077533651662,0.547309498185305,0.944397184580083,0.505233692208976,0.55422872947914,0.336858481539719,0.530287823234804,0.540718535570387,0.570287730969601,0.577904268074281,0.487896259471897,0.496666837673963,0.538018956229606,0.387420613024668,0.521120364160997,0.472794344232579,0.554591851340083,0.436887907632322,0.706240820406383,0.595096275896401,0.513670378253757,0.462618515368964,0.515161631469851,0.53095812797126,0.569482678647185,0.561822133012461,0.60497845301174,0.806642332719446,0.481775923570652,0.458122037764272,0.578923808802425,0.465867704712641,0.456165596040566,0.528161548594151,0.560721322504856,0.553309187141849,0.430875077029353,0.464993318510041,0.556518355711899,0.548583920816883,0.485975751328469,0.678152914945694,0.510511512046377,0.525962143072954,0.494906717671061,0.504429522624009,0.566956910957588,0.506422502520232,0.448682980493916]
["C2",null,0.703412214679679,0.538147511040239,0.491797310834774,0.939438945083555,0.531783036318663,0.574720159792678,0.331854319011743,0.527655690778181,0.510516955783991,0.609950118648715,0.646975984125342,0.514773434206332,0.500424011965845,0.562711220769432,0.253608763545545,0.600657130926143,0.560569204286329,0.577960903127092,0.498442233368579,0.668473213970475,0.601908341096439,0.495183154022975,0.487903944770052,0.522818392603005,0.535391815599355,0.592587418873194,0.576093214400807,0.638738109354186,0.803732422722758,0.481629831930494,0.487128038987768,0.59278384046733,0.422009196061019,0.511516738479556,0.540755374909542,0.530162059871137,0.796119929095656,0.434602093132765,0.476983702302293,0.57077460545889,0.565164945020327,0.48402353659296,0.703524604968239,0.547343030492218,0.528070247250498,0.499193731090841,0.542253097811017,0.459383294008717,0.522442063647339,0.52168153118516]
["C3",null,0.602367896443307,0.591861041350652,0.567939523463685,0.945490080828069,0.460437600527294,0.517577177121121,0.421503605799099,0.535922741403481,0.551159731243568,0.586326555494931,0.457468583328584,0.505459104521603,0.501045915091738,0.613799722156033,0.372709953892406,0.530201974823396,0.537989649217839,0.543193179936299,0.547646817723699,0.696336907503588,0.61634044432594,0.532641594683197,0.504525710340965,0.515417262932916,0.524707016175372,0.554574835767858,0.568451521796116,0.52763972634612,0.767181746490705,0.484110650333294,0.487853323130138,0.604968706409796,0.448028458931465,0.45514543550862,0.547328905567771,0.599933057090408,0.691066762503569,0.385224513262023,0.471767678938242,0.55818262783649,0.547932502529724,0.516003066297875,0.669135856837498,0.540553906461677,0.51440626235414,0.525097700766562,0.554161561497874,0.538019124582382,0.500528446158282,0.518374951910822]
["C4",null,0.634544262914451,0.734002782031563,0.574646880158908,0.94757788905792,0.46755792036498,0.570802551596834,0.390657054675742,0.541241585770354,0.575470971591324,0.568916232655669,0.949807527090155,0.527139040359076,0.498149733478166,0.611649499580613,0.384385704486098,0.648761736231731,0.580465116365406,0.586085864713581,0.479847562492313,0.662028818349384,0.600784831305875,0.58759148696136,0.500895332720044,0.500749155918735,0.52105994327004,0.568234146650497,0.564686920690212,0.609156191551809,0.830615841341487,0.505588792154616,0.477660536310715,0.598076131945789,0.476654042187546,0.455217727888514,0.548828141645584,0.615591616535726,0.621725539979289,0.378361113947829,0.464800353815034,0.534151931750029,0.555537618237045,0.517833849180558,0.69852125865097,0.556017619807867,0.487366854323889,0.554300787327475,0.555435268806798,0.532173658504851,0.514598200900602,0.519064625871825]
["C5",null,0.571141126723448,0.504081486943824,0.570317609866808,0.944958070055312,0.463577469731682,0.570412127557359,0.376772151374815,0.547700779836802,0.503395219480129,0.585921171754722,0.549901850747369,0.521810924761929,0.492414031363699,0.611111418617954,0.383453427511019,0.577649304120384,0.527579921663951,0.563413355519564,0.526473329078663,0.709626202921559,0.619382721242786,0.557841923009817,0.497389876058796,0.516456064851732,0.529735522644316,0.578723425528191,0.566506143228122,0.611061562924835,0.820013355977366,0.518223244849103,0.49493591369032,0.605160256224883,0.431277054828612,0.444432015841018,0.556045187010467,0.666718446859345,0.713177935693508,0.408573452411478,0.473432195290146,0.5588411049678,0.557083309070686,0.514797425487606,0.687344128197495,0.530410343594751,0.489778694871099,0.517611388015835,0.56378420535237,0.550732214131223,0.56093607248182,0.52769013275589]
["C6",null,0.641770575709932,0.494124926705113,0.574739658445587,0.935551617221037,0.481583452694792,0.586925917244036,0.415096297629511,0.557347245530387,0.595254724096754,0.571844263117646,0.56098536972773,0.529878083584632,0.505019637094289,0.631529258351889,0.305113542979834,0.547874036813145,0.568265356440477,0.566006011971631,0.550724827356516,0.680534639338475,0.628877338398086,0.511399310599139,0.522127854123203,0.532552949393456,0.544000066775814,0.606524165006329,0.577528857643453,0.620223968923756,0.811207551078872,0.527586822373217,0.461820012466201,0.598187452507806,0.507134225942298,0.457491611361994,0.572783307648039,0.702008911941415,0.691338322091357,0.426097972425648,0.479762321513743,0.567053120382826,0.554540935066687,0.535806195819543,0.791777948143982,0.548526808193596,0.499942733460773,0.548965196190335,0.555360292563469,0.557403321420991,0.560564674882204,0.55365367179617]
["C7",null,0.797759874264442,0.661411096211804,0.524494950983548,0.934033420262837,0.512602195752431,0.557031895769419,0.489438689752123,0.517120532342469,0.510710182154626,0.522497164157856,0.533465775308009,0.489026670579238,0.510630480080118,0.521847911111194,0.380183103689181,0.52726889328065,0.510592451904318,0.59021935421871,0.496939724703688,0.670855024731983,0.593873309702494,0.514464114385523,0.494809928524959,0.494616989179618,0.568406257689971,0.556961291622201,0.582344330491138,0.617721646779644,0.721314154552463,0.482398319477839,0.436470341066771,0.594779767013283,0.570429101047286,0.460702440275856,0.548990010325723,0.671685767135828,0.626057622914804,0.349429260688605,0.485933206416022,0.577433287212466,0.576999490143499,0.497544345864124,0.650093722532212,0.558531498778936,0.505883313818697,0.490528233224906,0.552192184121663,0.555810861216879,0.469448406480841,0.522514223908735]
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["P63","C2",0.667475827226889,0.57775135827383,0.51915298402264,0.936801971430653,0.511967564380676,0.497750727181156,0.629023707325601,0.558924079662954,0.501876183894161,0.487652416786647,0.466247408068963,0.414809299805078,0.480414613250598,0.534775288420308,0.240594102604123,0.569216715881645,0.504201424876369,0.669201100546821,0.46924882799571,0.708111666101398,0.593070725312135,0.576501272703097,0.470055153898521,0.105987302946407,0.512354205789727,0.576224697746997,0.603765774645879,0.555833936161048,0.699924290415745,0.359519648241448,0.458420898914266,0.536688702458052,0.209765196782072,0.517215308357015,0.523334352145027,0.548507106094847,0.655022772709518,0.473452072750594,0.458693378466056,0.558864502040918,0.575803131461187,0.442144811625636,0.704332311388895,0.534685857201635,0.533853638401287,0.441142618972511,0.529520649224175,0.450550725917299,0.497224409809026,0.44968699024319]
["P64","C2",0.654957306345731,0.472768915432657,0.503194750023656,0.937867684163556,0.52693213371657,0.533086415151449,0.126893563237627,0.510611702648373,0.451830089181924,0.346136033603841,0.528845218981045,0.475866734492616,0.479715219033132,0.528541168774953,0.221961208841687,0.557200710335647,0.517083092967681,0.537776734439232,0.464977757784548,0.673907380676364,0.582902594601114,0.533878374443062,0.489113076545304,0.188476082156163,0.527668193372336,0.571239421582961,0.53865968276398,0.572926044033431,0.825838838138508,0.443845804213325,0.456938336392172,0.593625597393364,0.403683838112161,0.410020780352989,0.503887560434657,0.510284234677777,0.616454579015604,0.398952678762472,0.458180057396319,0.546490894504606,0.533215608452801,0.444398625894463,0.619176609120955,0.510225248004798,0.527998516910753,0.4616072198291,0.475518522110619,0.499800989749165,0.540715224305476,0.418130935261462]

{"sheet":"S5","index":4,"n_rows":24,"n_cols":8,"rows_kept":24,"merged":[[1,0,1,1],[1,2,1,4],[1,5,1,6],[1,7,2,7],[5,0,6,0],[5,1,6,1],[5,4,6,4],[5,5,6,5],[5,6,6,6],[7,0,9,0],[7,1,9,1],[7,4,9,4],[7,5,9,5],[7,6,9,6],[10,0,11,0],[10,1,11,1],[10,4,11,4],[10,5,11,5],[10,6,11,6],[12,0,13,0],[12,1,13,1],[12,4,13,4],[12,5,13,5],[12,6,13,6],[14,0,15,0],[14,1,15,1],[14,4,15,4],[14,5,15,5],[14,6,15,6],[16,0,18,0],[16,1,18,1],[16,4,18,4],[16,5,18,5],[16,6,18,6],[21,0,22,0],[21,1,22,1],[21,4,22,4],[21,5,22,5],[21,6,22,6]]}
["Table S5. Probe coordinates for methylation analysis "]
["iDMRs",null,"MS-MLPA assay ME034-B1",null,null,"Methylation Array(GRCh37/hg19)",null,"Overlapping CpGs between MS-MLPA and EPIC "]
["Name","Position in GRCh37/hg19","Probe number","Region covered by MS-MLPA probes","number CpGs ","Region covered by Methylation Array probes ","number CpGs"]
["PLAGL1:alt-TSS-DMR","chr6:144,328,078-144,329,888","18460-L24410","chr6:144,328,907-144,328,970",1,"chr6:144,328,421-144,329,887",15,"NO"]
["GRB10:alt-TSS-DMR","chr7:50,848,726-50,851,312","15744-L24405","chr7:50,850,501-50,850,561",1,"chr7:50,849,168-50,850,870",10,"NO"]
["MEST:alt-TSS-DMR","chr7:130,130,122-130,134,388","19546-L17775","chr7:130,131,350-130,131,413 ",2,"chr7:130,130,122-130,134,256",51,"chr7:130,131,403-130,131,403 (cg04678950)"]
[null,null,"21198-L17768","chr7:130,132,134-130,132,188",{"$nulls":3},"chr7:130,132,161-130,132,161 (cg05556276)"]
["H19/IGF2:IG-DMR","chr11:2,018,812-2,024,740","06266-L05772","chr11:2,019,379-2,019,430",3,"chr11:2,019,079-2,024,126",35,"NO"]
[null,null,"14063-L08764","chr11:2,019,693-2,019,745",{"$nulls":3},"chr11:2,019,736-2,019,736 (cg01977486)"]
[null,null,"08743-L20532","chr11:2,020,007-2,020,055",{"$nulls":3},"NO"]
["KCNQ1OT1:TSS-DMR","chr11:2,719,948-2,722,259","07171-L06780","chr11:2,720,542-2,720,594",2,"chr11:2,720,229-2,722,195",25,"NO"]
[null,null,"07172-L06781","chr11:2,721,017-2,721,068",{"$nulls":3},"NO"]
["MEG3:TSS-DMR","chr14:101,290,524-101,293,978","15754-L18942","chr14:101,292,046-101,292,109",2,"chr14:101,290,556-101,293,856",35,"NO"]
[null,null,"19547-L25282","chr14:101,292,326-101,292,391",{"$nulls":3},"NO"]
["SNURF:TSS-DMR","chr15:25,200,004-25,201,976","04106-L13905","chr15:25,200,121-25,200,178",2,"chr15:25,200,113-25,201,732",10,"chr15:25,200,133-25,200,133 (cg17916021)"]
[null,null,"04103-L02951","chr15:25,200,680-25,200,739",{"$nulls":3},"NO"]
["PEG3:TSS-DMR","chr19:57,348,493-57,353,271","19532-L26047","chr19:57,349,964-57,350,021",3,"chr19:57,348,529-57,353,128",34,"NO"]
[null,null,"19531-L26046","chr19:57,351,691-57,351,751",{"$nulls":3},"NO"]
[null,null,"12861-L13981","chr19:57,352,215-57,352,278",{"$nulls":3},"NO"]
["GNAS-NESP:TSS-DMR","chr20:57,414,039-57,418,612","18126-SP0007- L22614","chr20:57,414,926-57,415,012",1,"chr20:57,414,039-57,418,373",25,"chr20:57,414,960-57,414,960 (cg14597908)"]
["GNAS-AS1:TSS-DMR","chr20:57,425,649-57,428,033","22363-L22606","chr20:57,426,013-57,426,065",1,"chr20:57,425,979-57,427,977",60,"NO"]
["GNAS-XL:Ex1-DMR","chr20:57,428,905-57,431,463","19545-L17516","chr20:57,430,117-57,430,171",2,"chr20:57,429,025-57,431,303",6,"chr20:57,430,133-57,430,133 (cg26711395)"]
[null,null,"15645-L26874","chr20:57,430,193-57,430,258",{"$nulls":3},"NO"]
["GNAS A/B:TSS-DMR","chr20:57,463,265-57,465,201","03882-L22603","chr20:57,464,367-57,464,424",2,"chr20:57,463,265-57,465,175",39,"NO"]

{"sheet":"S6","index":5,"n_rows":12746,"n_cols":107,"rows_kept":562,"cut":true,"bounds":{"rows_first":250,"rows_last":62,"rows_between":250,"halvings":3}}
["Table S6. DMPs analysis"]
["probeID","C1","C2","C3","C4","C5","C6","C7","C8","C9","C10","C11","C12","C13","C14","C17","C18","C19","C20","C21","C22","C23","C24","C25","C26","C27","C28","C29","C31","C32","C33","C34","C35","C36","C37","C38","C39","C40","P1","P2","P3","P4","P5","P6","P7","P8","P9","P10","P11","P12","P13","P14","P15","P16","P17","P18","P19","P20","P21","P22","P23","P24","P25","P26","P27","P28","P29","P30","P31","P32","P33","P34","P35","P36","P37","P38","P39","P40","P41","P42","P43","P44","P45","P46","P47","P48","P49","P50","P51","P52","P53","P54","P55","P56","P57","P58","P59","P60","P61","P62","P63","P64","c1","c2","c3","diff","cluster"]
["cg05650511",0.632120114185305,0.675275447928326,0.594429566848155,0.6585539405454,0.653455432140219,0.743539952650103,0.378137109350957,0.632700904129318,0.741347778085964,0.74045208222398,0.684714288806208,0.719032208971408,0.779186106050155,0.605292868226067,0.652640531574026,0.759297775867821,0.704888125571974,0.66252841837236,0.584467683814694,0.603320314453028,0.581146981538693,0.758675931894261,0.579206896522762,0.663527215546891,0.673983953756726,0.69747027546585,0.629432075654532,0.778720473835632,0.762411033389176,0.667602125611327,0.71438069870233,0.842132286912813,0.654482933529011,0.577358722621521,0.644765674395665,0.646864301255403,0.566898233143664,0.678972128027596,0.678067458612277,0.723963281617995,0.855643508368528,0.663119786203889,0.608220344360671,0.813035036918385,0.591569537307504,0.661679054821642,0.615002176806989,0.884542301201626,0.712665923065185,0.884482924868671,0.615938469453059,0.782313173541733,0.852356192866643,0.68722191421512,0.843097867848807,0.712584185971164,0.824542277511863,0.608794319922196,0.839594627787086,0.837545257900556,0.749346803997305,0.709896376469546,0.661042066033521,0.852556594372771,0.842808365399783,0.497826859304932,0.848213562173328,0.695721275339565,0.796906846981435,0.730906253679617,0.831218459786319,0.649345547341213,0.693055464227428,0.895111949159261,0.727981398621816,0.755175749648277,0.878598942785549,0.843692275829288,0.853691151943637,0.835992866921055,0.782624713072758,0.617575355277344,0.841050221632246,0.758371375110441,0.735320861969894,0.677226415217627,0.85081582051816,0.661908235631809,0.834443367181387,0.749754708121241,0.649701403506333,0.602095960574814,0.875087392543672,0.798735569995538,0.872776334916907,0.839299083659862,0.649436150087102,0.858563065082184,0.860214309585568,0.780169490497348,0.866862547942295,0.666065958474912,0.771184887158401,0.741193168648115,0.105118928683489,"c2"]
["cg10732921",0.304451801841217,0.260368485812394,0.316780010076829,0.281998567982424,0.316117414702158,0.297007042696559,0.159855147506629,0.262126067926997,0.34012134886299,0.345368611760898,0.326805780933252,0.291970386880607,0.410153398005864,0.215484238029045,0.399575425376603,0.45491058305633,0.274436679169532,0.349461901976439,0.272713613562919,0.246613965501203,0.230594713891572,0.41166568322517,0.225564768619528,0.239050382246675,0.28817434185956,0.395698173765857,0.230398678697672,0.546700944509,0.3904092829972,0.302793464355403,0.331517420158999,0.54795480342354,0.202881285712877,0.200220502884604,0.235913567098606,0.246254521929138,0.212062355578224,0.359910315673371,0.350898311098942,0.324357165301778,0.533030900449585,0.236565976524579,0.207461751627315,0.449217493189601,0.231309206294897,0.236945869204165,0.346015569787011,0.637230743577261,0.337954059142022,0.582589086274913,0.262266382520572,0.54870605557418,0.492713003843328,0.321415465056265,0.541222617075929,0.295837475956047,0.537317817727818,0.287318014860671,0.598299986107973,0.558912276974503,0.349433478712933,0.43364990241917,0.301366144171216,0.608819618271844,0.534051374552279,0.171716009234404,0.55914229108405,0.34907962556083,0.458498231890142,0.337657140390401,0.486258255844401,0.295327735542239,0.319744783057445,0.628833544436319,0.548396964873121,0.370909180827386,0.50104026763259,0.536648798432166,0.572369577209775,0.501736728925335,0.4644580285021,0.212861812442541,0.615136606597859,0.561350565631058,0.481069033269861,0.354806580788818,0.439434849144522,0.198095233898738,0.538031048136862,0.564248987963426,0.218787468095259,0.268957506593003,0.642211718336104,0.492854387202808,0.525047208505329,0.611835736677479,0.282638102425831,0.611641245708933,0.506837862515615,0.235101457524622,0.598503844393708,0.307139874665257,0.44356083396033,0.415222596298404,0.136420959295073,"c2"]
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{"sheet":"S7","index":6,"n_rows":11198,"n_cols":103,"rows_kept":562,"cut":true,"bounds":{"rows_first":250,"rows_last":62,"rows_between":250,"halvings":3}}
["Table S7. DVPs analysis"]
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["cg25560398",0.497547732140381,0.506017383836271,0.459502657894328,0.472099363636802,0.45194662258525,0.467488786055179,0.512580891179157,0.512914186494812,0.462681107670315,0.43917676060525,0.453178729005872,0.456774832254636,0.428111373332234,0.528482025013276,0.510371940391719,0.295835662006759,0.485094276943479,0.482231025750213,0.503399978228407,0.512798097399911,0.543390974397991,0.39344270922233,0.499913239861325,0.532106326993847,0.493626605874242,0.482166471566091,0.553372513673025,0.182513224770608,0.412359056009588,0.446757026659551,0.465250832672909,0.121656926714542,0.50361449177415,0.50221077935926,0.508571449323556,0.520605365013283,0.534809420597618,0.484660894723913,0.441614944141182,0.445291009921182,0.198516175043158,0.497700452129324,0.469584979892199,0.27528305290534,0.43080800635636,0.406988233186118,0.501142657697028,0.157939405113159,0.397004948758055,0.195880950855842,0.449611195851335,0.133585172481017,0.158154756216639,0.504217171359342,0.203139409882925,0.539987959527356,0.173161533814738,0.532302390373361,0.0936877244090154,0.144197035294746,0.469742749257431,0.235991529329706,0.482979511216016,0.170024759912655,0.135892123214315,0.523942775193786,0.0963691202703105,0.516253445304572,0.231095795207206,0.382551656232327,0.30642796232356,0.500398600740863,0.419782446407557,0.106415244269015,0.0968663101966837,0.406016842887899,0.125497009005813,0.1441845917626,0.120434282088885,0.130199431776461,0.370650308947155,0.507768174582873,0.13159609952841,0.144252159617301,0.176826169895572,0.471023490630175,0.377768336964882,0.494870388999983,0.297796961165638,0.337588672495534,0.499065093738706,0.49859507802906,0.229424917910225,0.379371387135211,0.109786128342167,0.141542231439324,0.493783766959795,0.128385300615081,0.384249825874636,0.460563179819779,0.178046247321298,"c2"]
["cg25763542",0.750870194437852,0.910304792449845,0.825767742374159,0.861634179569277,0.86993266881067,0.865097037207731,0.869229258113795,0.882372073115286,0.912456688519352,0.882120662539365,0.878880264380027,0.619713580602363,0.854889086102176,0.877541169474781,0.850002051778173,0.881274379745974,0.813166387858174,0.853706980053926,0.884464580503073,0.839838850795557,0.907962962421048,0.858831172852933,0.900243453480309,0.877837593657219,0.891103294332758,0.874741901007592,0.856479512073283,0.875061295353551,0.855306031262549,0.876792537884054,0.853944098807175,0.877982797474164,0.855517407061314,0.868313678956466,0.84488032367897,0.88476436800283,0.864956788186831,0.864948260882822,0.852356116787855,0.806498296449676,0.856607124147178,0.896838136038684,0.885816237926208,0.850517207123186,0.884016746397055,0.870348458138531,0.851154797607545,0.87559668623332,0.843656226868043,0.795559060933239,0.887165045887992,0.736405897636892,0.762680784983785,0.857967459360152,0.813069774541678,0.852348317315402,0.572177258361674,0.881944346114332,0.846108492109626,0.866381842453701,0.87849715778839,0.885544916554635,0.871932239257773,0.891956551585303,0.900012037230713,0.591402712319733,0.805347990332268,0.84978564017649,0.778441745705272,0.615984275381345,0.906298882306294,0.903429468386319,0.839963979642814,0.543482985114627,0.678027239573196,0.880371413126379,0.877713229658652,0.886085793013716,0.883511168147312,0.538864452784324,0.86237666820376,0.841534962330279,0.832152595977521,0.780374171873088,0.850644440536079,0.825766798565889,0.860865826732761,0.868238332087163,0.881055300634258,0.866418890753342,0.846898628118278,0.844911231430421,0.859279159076083,0.868886977161741,0.87663136421657,0.688639209359095,0.893112484496272,0.860014942745548,0.889744477486724,0.70470734926299,0.862871830933832,"c2"]
["cg10621924",0.794959843838245,0.700380968519894,0.759339835061993,0.750401040773743,0.768925805729584,0.854384663533108,0.637250298288173,0.616137684038266,0.810650248700848,0.719500329356381,0.829648223807482,0.631494750778573,0.700247340767671,0.746865361196681,0.716825089679735,0.699574405807029,0.830048108650639,0.787633902800146,0.835680995701753,0.943034657292336,0.837438376201866,0.679638181599095,0.776398102901897,0.853666286654063,0.699247863820556,0.739241573550114,0.699290859229309,0.767854932009075,0.781089293643049,0.696331567510105,0.740816814329316,0.864615603311605,0.669077529009033,0.680570314023881,0.704952481257905,0.656636497546239,0.755335501514203,0.775020499861153,0.763398307442875,0.654511239724044,0.731306796323656,0.899589119958615,0.924932983705672,0.802991617650827,0.898489823326761,0.762832484601076,0.725952826012333,0.808535983847657,0.808569979071367,0.655582693397486,0.829440793065491,0.750455468012462,0.65188879340824,0.724092814699436,0.930103219025724,0.620542791031191,0.969909465840518,0.876683784898771,0.715286863926538,0.71041875485906,0.570856278842458,0.878754053030182,0.831901554994373,0.886688469295388,0.872355417119321,0.444185032380901,0.630098648852245,0.932632403088092,0.852002175615633,0.702864888757769,0.828267174438034,0.891016563386358,0.89345225151384,0.737719710639669,0.942496752275523,0.666817933642507,0.825948129234001,0.659485135867135,0.909147179857957,0.645643476752797,0.53534369684962,0.929078189398642,0.943508694758947,0.749419788312995,0.698957426940374,0.775459810310153,0.626041596587691,0.893154620542971,0.802954605548062,0.848474915313955,0.947406809386007,0.79681364603012,0.730281531543624,0.796495357065764,0.595792664012139,0.956167226538949,0.793763087322872,0.662748333336278,0.760514621543703,0.940462921703887,0.816981508676,"c2"]

{"sheet":"S8","index":7,"n_rows":40,"n_cols":6,"rows_kept":40}
["Table S8. DVPs cancer related genes"]
["gene","feature","dvp_count","Anno","total_probes","norm_density"]
["B4GALT5","Body",10,"GeneBody",26,0.384615384615385]
["SLC12A9","Body",7,"GeneBody",20,0.35]
["SNED1","Body",12,"GeneBody",71,0.169014084507042]
["NFIX","Body",12,"GeneBody",83,0.144578313253012]
["ZEB2","Body",10,"GeneBody",83,0.120481927710843]
["VARS","Body",9,"GeneBody",81,0.111111111111111]
["LOC404266","Body",6,"GeneBody",58,0.103448275862069]
["MGLL","Body",7,"GeneBody",68,0.102941176470588]
["KSR1","5'UTR",7,"Promoter",71,0.0985915492957746]
["BCL11A","Body",7,"GeneBody",83,0.0843373493975904]
["ZMIZ1","Body",7,"GeneBody",86,0.0813953488372093]
["PIK3AP1","Body",6,"GeneBody",78,0.0769230769230769]
["MED13L","Body",6,"GeneBody",89,0.0674157303370786]
["PVT1","Body",8,"GeneBody",122,0.0655737704918033]
["CHST11","Body",8,"GeneBody",124,0.0645161290322581]
["UBAC2","Body",6,"GeneBody",93,0.0645161290322581]
["PBX1","Body",7,"GeneBody",117,0.0598290598290598]
["ARHGAP26","Body",10,"GeneBody",169,0.0591715976331361]
["ETV6","Body",6,"GeneBody",108,0.0555555555555556]
["ZDHHC14","Body",8,"GeneBody",145,0.0551724137931034]
["PREX1","Body",6,"GeneBody",115,0.0521739130434783]
["COL23A1","Body",11,"GeneBody",230,0.0478260869565217]
["EBF1","Body",6,"GeneBody",128,0.046875]
["SYN3","Body",7,"GeneBody",155,0.0451612903225806]
["SEPT9","Body",6,"GeneBody",145,0.0413793103448276]
["SH3PXD2A","Body",7,"GeneBody",180,0.0388888888888889]
["NCOR2","Body",8,"GeneBody",218,0.036697247706422]
["JARID2","Body",6,"GeneBody",165,0.0363636363636364]
["HIVEP3","5'UTR",6,"Promoter",166,0.036144578313253]
["PRKCA","Body",6,"GeneBody",179,0.0335195530726257]
["PARD3","Body",6,"GeneBody",194,0.0309278350515464]
["CUX1","Body",7,"GeneBody",309,0.0226537216828479]
["HDAC4","Body",9,"GeneBody",404,0.0222772277227723]
["CAMTA1","Body",9,"GeneBody",431,0.0208816705336427]
["MAD1L1","Body",14,"GeneBody",797,0.0175658720200753]
["RPTOR","Body",7,"GeneBody",524,0.0133587786259542]
["PRDM16","Body",8,"GeneBody",631,0.0126782884310618]
["PTPRN2","Body",13,"GeneBody",1453,0.00894700619408121]

{"sheet":"S9","index":8,"n_rows":33,"n_cols":8,"rows_kept":33}
["Table S9. 2 kb windows with >3 DVPs"]
["probe","cluster_index","gene","chr","pos","strand","Relation_to_Island","UCSC_RefGene_Group"]
["cg00072689",2085,"LOC404266;LOC404266;HOXB6","chr17",46681111,"-","OpenSea","Body;Body;5'UTR"]
["cg01986016",2085,"LOC404266;LOC404266;HOXB6","chr17",46681154,"-","OpenSea","Body;Body;5'UTR"]
["cg03803541",2085,"LOC404266;LOC404266;HOXB6","chr17",46681401,"+","N_Shelf","Body;Body;5'UTR"]
["cg04588674",2085,"HOXB6;HOXB-AS3;HOXB-AS3","chr17",46682410,"+","N_Shelf","TSS200;Body;Body"]
["cg05900563",2085,"HOXB-AS3;HOXB-AS3;HOXB6","chr17",46681550,"-","N_Shelf","Body;Body;5'UTR"]
["cg15435170",2085,"LOC404266;LOC404266;HOXB6","chr17",46681135,"-","OpenSea","Body;Body;5'UTR"]
["cg17179862",2085,"LOC404266;LOC404266;HOXB6","chr17",46681362,"+","N_Shelf","Body;Body;5'UTR"]
["cg20471691",2085,"LOC404266;LOC404266;HOXB6","chr17",46681316,"+","N_Shelf","Body;Body;5'UTR"]
["cg00325531",3907,null,"chr1",75591353,"+","Island"]
["cg01005080",3907,"LHX8","chr1",75592950,"-","S_Shore","TSS1500"]
["cg01066472",3907,null,"chr1",75591029,"+","Island"]
["cg01259156",3907,"LHX8","chr1",75594592,"-","N_Shore","5'UTR"]
["cg01540595",3907,null,"chr1",75590960,"+","Island"]
["cg01971160",3907,"LHX8","chr1",75593804,"+","N_Shelf","TSS1500"]
["cg09766820",3907,"LHX8","chr1",75593018,"-","S_Shore","TSS1500"]
["cg00202479",7077,"VARS","chr6",31760383,"-","N_Shelf","Body"]
["cg02597894",7077,"VARS","chr6",31760796,"-","N_Shelf","Body"]
["cg04018738",7077,"VARS","chr6",31760616,"+","N_Shelf","Body"]
["cg04368724",7077,"VARS","chr6",31760593,"+","N_Shelf","Body"]
["cg05302489",7077,"VARS","chr6",31760426,"+","N_Shelf","Body"]
["cg08899667",7077,"VARS","chr6",31761055,"-","N_Shelf","Body"]
["cg10807309",7077,"VARS","chr6",31761062,"-","N_Shelf","Body"]
["cg23781467",7077,"VARS","chr6",31760233,"-","N_Shelf","Body"]
["cg24771152",7077,"VARS","chr6",31760608,"+","N_Shelf","Body"]
["cg06213468",7848,"FOXI2","chr10",129534411,"-","Island","TSS1500"]
["cg06566669",7848,"FOXI2","chr10",129536394,"+","Island","Body"]
["cg14479798",7848,null,"chr10",129533998,"-","N_Shore"]
["cg14644418",7848,"FOXI2","chr10",129536661,"+","Island","Body"]
["cg18047662",7848,"FOXI2","chr10",129534217,"+","N_Shore","TSS1500"]
["cg18462381",7848,"FOXI2","chr10",129536718,"-","Island","Body"]
["cg25043050",7848,"FOXI2","chr10",129534107,"+","N_Shore","TSS1500"]

{"sheet":"S10","index":9,"n_rows":36,"n_cols":10,"rows_kept":36,"merged":[[1,0,2,0],[1,1,1,5],[1,6,1,7],[1,8,2,8],[1,9,2,9],[3,0,4,0],[3,1,6,1],[3,2,6,2],[3,8,6,8],[3,9,6,9],[5,0,6,0],[8,0,9,0],[8,1,11,1],[8,2,11,2],[8,8,11,8],[8,9,11,9],[10,0,11,0],[13,0,14,0],[13,1,14,1],[13,2,14,2],[13,8,14,8],[13,9,14,9],[22,0,24,0],[22,1,23,1],[22,2,23,2],[22,8,24,8],[22,9,24,9],[26,0,28,0],[26,1,28,1],[26,2,28,2],[26,8,28,8],[26,9,28,9],[32,0,33,0],[32,1,33,1],[32,2,33,2],[32,8,33,8],[32,9,33,9]]}
["Table S10. List of the SCMC gene variants identifiend in the patients'mothers"]
["Familiy/BWS patient","Maternal effect variant",{"$nulls":4},"Genotype",null,"Maternal reproductive history","Publications"]
[null,"Gene","Transcript","DNA variation ","Molecular effect","Predicted protein","Mother ","Proband"]
["P1","NLRP5","NM_153447.4","c.1057C>T","stop gain ","p.Arg353Ter","het","wt","Four miscarriages","Sparago et al., 2019 (Clin Epigenetics) "]
[{"$nulls":3},"c.1597C>T","missense","p.Arg533Cys","het","het"]
["P2",null,null,"c.1057C>T","stop gain ","p.Arg353Ter","het","het"]
[{"$nulls":3},"c.1597C>T","missense","p.Arg533Cys","het","wt"]
[]
["P3","PADI6","NM_207421.4","c.1067G>A","stop gain ","p.Trp356Ter","het","wt","None","Cubellis et al.,2020 (Clin Epigenetics; Family 1)"]
[{"$nulls":3},"c.1894C>G","missense","p.Pro632Ala ","het","het"]
["P4",null,null,"c.1067G>A","stop gain ","p.Trp356Ter","het","wt "]
[{"$nulls":3},"c.1894C>G","missense","p.Pro632Ala ","het","het"]
[]
["P5","PADI6","NM_207421.4","c.1429A>G","missense","p.Met477Val ","het","wt","One miscarriage","Cubellis et al.,2020 (Clin Epigenetics; Family 2)"]
[{"$nulls":3},"c.2080C>T","missense","p.Pro694Ser","het","het"]
[]
["P6","PADI6","NM_207421.4","c.2006delC","frameshift deletion","p.T669Kfs*85","het ","het","None","Cubellis et al.,2020 (Clin Epigenetics; Family 3)"]
[]
["P9","PADI6","NM_207421.4","c.356 T > C","missense","p.Leu119Pro","het","het","Two miscarriages and one stillborn","Pignata et al., 2022 (Clin Epigenetics; Family 2)"]
[]
["P12","KHDC3L","NM_001017361","c.296C > G","missense","p.Thr99Arg","hom","het","None","Pignata et al., 2022 (Clin Epigenetics; Family 1); Bliek et al.,2009 (Eur J Hum Genet;BWS3) "]
[]
["P14","NLRP5","NM_153447.4","c.2615G > A","missense","p.Arg872Lys","het","wt","Ovarian stimlation          Four miscarriages and two stillborns","Pignata et al., 2022 (Clin Epigenetics; Family 3)"]
[{"$nulls":3},"c.3584G > A","missense","p.Arg1195Gln","het","het"]
[null,"NLRP4","NM_134444.4","c.1279G > A","missense","p.Ala427Thr","het","het"]
[]
["P17","NLRP5 ","NM_153447.4","c.1685G > A","missense","p.Arg562His","het","wt","Proband born by in vitro fertlization ","Pignata et al., 2022 (Clin Epigenetics; Family 4)"]
[{"$nulls":3},"c.3323C > G","missense","p.Ser1108Cys","hom ","het"]
[{"$nulls":3},"c.3584G > A","missense","p.Arg1195Gln","hom ","het"]
[]
["P18","NLRP2","NM_017852.4","c.662C > T","missense","p.Thr221Met","het","het","None","Pignata et al., 2022 (Clin Epigenetics; Family 6)"]
[]
["P21","NLRP2","NM_017852.4","c.1681G > A","missense","p.Ala561Thr","het","wt","One miscarriage ","Pignata et al., 2022 (Clin Epigenetics; Family 5)"]
[{"$nulls":3},"c.662C > T","missense","p.Thr221Met","het","het"]
[]
["P52","PADI6","NM_207421.4","c.1684G>A","missense","p.Val562Met","het","wt","None","Present study"]

{"sheet":"S11","index":10,"n_rows":106,"n_cols":1,"rows_kept":106}
["Table S11: Maternal-effect genes list"]
["ATG5"]
["ATM"]
["BCAS2"]
["BNC1"]
["ZFP36L2"]
["CDC20"]
["CDX2"]
["DDB1"]
["DGCR8"]
["DNMT1"]
["DNMT3A"]
["DNMT3L"]
["EED"]
["AGO2"]
["ESR2"]
["EZH2"]
["GAS6"]
["GJA4"]
["GCLM"]
["HIST1H2AB"]
["H3F3B"]
["HIST1H3F"]
["HIST1H4F"]
["HIRA"]
["HSF1"]
["KPNA6"]
["MAPK1"]
["MAPK3"]
["MGAT1"]
["MLH3"]
["KMT2D"]
["NPM2"]
["PDK1"]
["PIK3R1"]
["PLAG1"]
["PMS2"]
["EXOSC10"]
["POU5F1"]
["RAD9A"]
["RING1"]
["RNF2"]
["SETDB1"]
["SLBP"]
["SMARCA4"]
["ARID1A"]
["SOX2"]
["TCL1A"]
["TRIM24"]
["MED12"]
["TP73"]
["HSP90B1"]
["TRIP13"]
["UBA7"]
["UBE2A"]
["UCHL1"]
["UHRF1"]
["BRWD1"]
["XIST"]
["RLIM"]
["CTCF"]
["BTG4"]
["FMN2"]
["EHMT2"]
["PUM1"]
["YAP1"]
["TRIM28"]
["DICER1"]
["CNOT6L"]
["DMAP1"]
["SETD2"]
["HIST1H2AA"]
["HIST1H2BA"]
["ZFP57"]
["DPPA3"]
["ZAR1"]
["PADI6"]
["ZBED3"]
["TUBB8"]
["NLRP5"]
["OOEP"]
["KDM1B"]
["BCAR4"]
["NOBOX"]
["NLRP9"]
["NLRP4"]
["NLRP7"]
["NLRP2"]
["KDM4A"]
["CXXC1"]
["DCAF13"]
["FIGLA"]
["TUT7"]
["TET3"]
["IGF2BP2"]
["TUT4"]
["KDM1A"]
["DTL"]
["TLE6"]
["MIR196A1"]
["MIR212"]
["MIR181A1"]
["YTHDF2"]
["SEBOX"]
["PATL2"]
["KHDC3L"]

{"sheet":"S12","index":11,"n_rows":30,"n_cols":16,"rows_kept":30}
["Table S12: List of MEG variants identifiend in the patients'mothers"]
["Cluster","Sample","Gene","SCMC variant","Ref","Alt","hg19 position","dbSNP","Transcript","AA Change","Nucleotide","Zygosity","Effect","GnomAD","SIFT Pred","POLYPHEN Pred"]
["C3","P1_P2","UBA7","Biallelic","G","A"," chr3:49846852 ","rs11928913","NM_003335.3","p.Pro712Ser","c.2134C>T","het","Missense","0.002001026","Deleterious","Deleterious"]
["C3","P1_P2","UHRF1","Biallelic","G","C","chr:19:4932901","rs17886098","NM_001048201.3","p.Asp240His","c.718G>C","het","Missense","0.0013823895","Deleterious","Deleterious"]
["C3","P3_P4","UCHL1","Biallellic","T","C","chr4:41265306","-","NM_004181.5","p.Leu175Pro","c.524T>C","het","Missense","NA","Deleterious","NA"]
["C3","P6","DCAF13","Monoallelic","A","C","chr8:104444924 ","rs772398473","NM_015420.7","p.Asn247Thr","c.740A>C","het","Missense","0.000002063","Uncertain","Deleterious"]
["C3","P8","TET3","No","C","G","chr2:74213706","rs1296234995","NM_001287491.2","p.Thr59Ser","c.176C>G","het","Missense",{"v":0.0004,"d":"4.00E-04"},"Tolerated","Deleterious"]
["C3","P8","ESR2","No","T","G","chr14:64694749","rs17225885","NM_001271876.1","p.Lys474Thr","c.1421A>C","het","Missense","0.072013445","Deleterious","NA"]
["C3","P9","KMT2D","Monoallelic","A","G","chr12:49434409","rs80132640","NM_003482.4","p.Ser4010Pro","c.12028T>C","het","Missense","0.026749685","Deleterious","NA"]
["C3","P10","KMT2D","No","A","G","chr12:49434409","rs80132640","NM_003482.4","p.Ser4010Pro","c.12028T>C","het","Missense","0.026749685","Deleterious","NA"]
["C3","P11","BRWD1","No","G","A","chr21:40630521 ","rs750882690","NM_033656.4","p.Leu655Phe","c.1963C>T","het","Missense","0.00003422","Uncertain","Deleterious"]
["C3","P11","UBA7","No","G","A"," chr3:49846852 ","rs11928913","NM_003335.3","p.Pro712Ser","c.2134C>T","het","Missense","0.002001026","Deleterious","Deleterious"]
["C3","P12","KMT2D","Biallelic","C","T","chr:12:49433994 ","rs369965791","NM_003482.4","p.Arg2520Gln","c.7559G>A","het","Missense","0.00004723","Deleterious","Deleterious"]
["C3","P16","TET3","No","C","T","chr2:74274329","rs61741171","NM_001287491.2","p.Pro429Ser","c.1285C>T","het","Missense","0.04346159","Deleterious","Uncertain"]
["C3","P16","SETDB1","No","G","T","chr1:150917624","rs186820437","NM_001243491.2","p.Gly394Trp","c.1180G>T","het","Missense","0.014361954","Deleterious","Benign"]
["C3","P17","KMT2D","Biallelic","G","A","chr12:49434409","rs3741626","NM_003482.4","p.Pro2382Ser","c.7144C>T","het","Missense","0.011941084","Deleterious","Benign"]
["C3","P18","UBA7","Monoallelic","C","T","chr3:49847804","rs115185290","NM_003335.3","p.Val509Met","c.1525G>A","het","Missense","0.0019170524","Uncertain","Deleterious"]
["C3","P18","UBA7","Monoallelic","G","A","chr3:49846852","rs11928913","NM_003335.3","p.Pro712Ser","c.2134C>T","het","Missense","0.002001026","Deleterious","Deleterious"]
["C2","P26","ESR2","No","T","G","chr14:64694749","rs17225885","NM_001271876.1","p.Lys474Thr","c.1421A>C","het","Missense","0.072013445","Deleterious","NA"]
["C3","P30","TP73","No","C","T","chr1:3649359","rs769290913","NM_005427.4","p.Arg543Trp","c.1627C>T","het","Missense","0.00001240","Deleterious","Deleterious"]
["C3","P31","TUT7","No","C","A","chr9:88959913","rs150701408","NM_024617.4","p.Val326Leu","c.976G>T","het","Missense","0.00016739224","Benign","Deleterious"]
["C2","P32","TET3","No","C","T","chr2:74274329","rs61741171","NM_001287491.2","p.Pro429Ser","c.1285C>T","het","Missense","0.04346159","Deleterious","Uncertain"]
["C2","P32","KMT2D","No","A","G","chr12:49434409","rs80132640","NM_003482.4","p.Ser4010Pro","c.12028T>C","het","Missense","0.026749685","Deleterious","NA"]
["C2","P33","ESR2","No","G","T","chr14:64749369 ","rs141516067","NM_001437.3","p.Ser112*","c.335C>A","het","Stop Gain","0.00012735763","NA","NA"]
["C2","P34","KMT2D","No","A","G","chr12:49434409","rs80132640","NM_003482.4","p.Ser4010Pro","c.12028T>C","het","Missense","0.026749685","Deleterious","NA"]
["C2","P35","KMT2D","No","G","A","chr12:49434801","rs189199944","NM_003482.4","p.Ser2251Leu","c.6752C>T","het","Missense","0.0021998917","Deleterious","Deleterious"]
["C3","P52","ESR2","Monoallelic","T","G","chr14:64694749","rs17225885","NM_001271876.1","p.Lys474Thr","c.1421A>C","het","Missense","0.05334713","Deleterious","NA"]
["C3","P56","TET3","No","C","T","chr2:74274329","rs61741171","NM_001287491.2","p.Pro429Ser","c.1285C>T","het","Missense","0.04346159","Deleterious","Uncertain"]
["C3","P60","TP73","No","C","T"," chr1:3607292","rs371650314","NM_001126240.3","NA","c.-178C>T","het","Start Gain","0.0007925318","NA","NA"]
["C3","P60","ESR2","No","T","G","chr14:64694749","rs17225885","NM_001271876.1","p.Lys474Thr","c.1421A>C","het","Missense","0.05334713","Deleterious","NA"]