{"text_format":"3","workbook":"xls","n_sheets":1,"sheets":["Supp Table 5"],"not_rendered":{"external_links":1},"read":"whole","date_system":"1900","formulas":"cached_only"}

{"sheet":"Supp Table 5","index":0,"n_rows":224,"n_cols":5,"rows_kept":224,"merged":[[0,0,0,4]],"flags":["formulas_cached_only"]}
[]
[]
["Canonical Pathways","AmnionEVs_vs-inflamed_logFC","WJEVs_vs_inflamed_syn_logFC","ChondroEVs_vs_inflamed_logFC","MSCEVs_vs_inflamed_logFC"]
["Neutrophil degranulation","N/A","N/A",-2.449,-3.162]
["LXR/RXR Activation","N/A","N/A",1,1.89]
["S100 Family Signaling Pathway","N/A","N/A",-1,-1.667]
["Neuroinflammation Signaling Pathway","N/A","N/A","N/A",-2.646]
["Cardiac Hypertrophy Signaling (Enhanced)","N/A","N/A","N/A",-2.236]
["Role of Chondrocytes in Rheumatoid Arthritis Signaling Pathway","N/A","N/A","N/A",-2.236]
["Pulmonary Healing Signaling Pathway","N/A","N/A","N/A",-2.236]
["Molecular Mechanisms of Cancer","N/A","N/A",0,-2.111]
["Hepatic Fibrosis Signaling Pathway","N/A","N/A",2,0]
["Deubiquitination","N/A","N/A","N/A",-2]
["IL-17 Signaling","N/A","N/A","N/A",-2]
["ID1 Signaling Pathway","N/A","N/A","N/A",-2]
["Hepatic Cholestasis","N/A","N/A","N/A",-2]
["IL-10 Signaling","N/A","N/A","N/A",2]
["Interleukin-10 signaling","N/A","N/A","N/A",-2]
["Osteoarthritis Pathway","N/A","N/A",0,-1.89]
["Atherosclerosis Signaling","N/A","N/A","N/A",-1.89]
["HOTAIR Regulatory Pathway","N/A","N/A","N/A",-1.633]
["Pathogen Induced Cytokine Storm Signaling Pathway","N/A","N/A","N/A",-1.633]
["Leukocyte Extravasation Signaling","N/A","N/A","N/A",-1.633]
["Extracellular matrix organization","N/A","N/A","N/A",1.633]
["Pulmonary Fibrosis Idiopathic Signaling Pathway","N/A","N/A","N/A",-1.633]
["Tumor Microenvironment Pathway","N/A","N/A","N/A",-1.414]
["Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis","N/A","N/A","N/A",-1.414]
["Glycosaminoglycan metabolism","N/A","N/A","N/A",1.342]
["Macrophage Alternative Activation Signaling Pathway","N/A","N/A","N/A",-1.342]
["IL-33 Signaling Pathway","N/A","N/A","N/A",-1.342]
["Colorectal Cancer Metastasis Signaling","N/A","N/A","N/A",-1.342]
["Role of Osteoblasts in Rheumatoid Arthritis Signaling Pathway","N/A","N/A","N/A",-1.342]
["Neutrophil Extracellular Trap Signaling Pathway","N/A","N/A","N/A",-1.342]
["Acute Phase Response Signaling","N/A","N/A","N/A",-1.342]
["Role of Osteoclasts in Rheumatoid Arthritis Signaling Pathway","N/A","N/A",0,-1.265]
["RAR Activation","N/A","N/A","N/A",1.134]
["Regulation of Insulin-like Growth Factor (IGF) transport and uptake by IGFBPs","N/A","N/A",1,0]
["Degradation of the extracellular matrix","N/A","N/A","N/A",-1]
["HMGB1 Signaling","N/A","N/A","N/A",-1]
["Collagen degradation","N/A","N/A","N/A",-1]
["Cell surface interactions at the vascular wall","N/A","N/A","N/A",-1]
["Post-translational protein phosphorylation","N/A","N/A",1,"N/A"]
["IL-17A Signaling in Fibroblasts","N/A","N/A","N/A",-1]
["Coronavirus Pathogenesis Pathway","N/A","N/A","N/A",-1]
["Cachexia Signaling Pathway","N/A","N/A","N/A",-1]
["Integrin cell surface interactions","N/A","N/A","N/A",-1]
["FXR/RXR Activation","N/A","N/A","N/A",1]
["CGAS-STING Signaling Pathway","N/A","N/A","N/A",-1]
["Serotonin Receptor Signaling","N/A","N/A","N/A",-0.816]
["Activin Inhibin Signaling Pathway","N/A","N/A","N/A",-0.816]
["G-Protein Coupled Receptor Signaling","N/A","N/A","N/A",-0.816]
["HIF1α Signaling","N/A","N/A","N/A",-0.816]
["NOD1/2 Signaling Pathway","N/A","N/A","N/A",-0.447]
["Wound Healing Signaling Pathway","N/A","N/A","N/A",-0.447]
["Hematoma Resolution Signaling Pathway","N/A","N/A","N/A",0.447]
["Senescence Pathway","N/A","N/A",0,0.447]
["Inhibition of Matrix Metalloproteases","N/A","N/A","N/A",0.447]
["Semaphorin Neuronal Repulsive Signaling Pathway","N/A","N/A","N/A",-0.378]
["MAPK targets/ Nuclear events mediated by MAP kinases","N/A","N/A","N/A","N/A"]
["Formation of axial mesoderm","N/A","N/A","N/A","N/A"]
["Apelin Cardiac Fibroblast Signaling Pathway","N/A","N/A","N/A","N/A"]
["TP53 Regulates Transcription of Cell Cycle Genes","N/A","N/A","N/A","N/A"]
["Nicotinate metabolism","N/A","N/A","N/A","N/A"]
["Arginine Degradation VI (Arginase 2 Pathway)","N/A","N/A","N/A","N/A"]
["Transcriptional Regulation by VENTX","N/A","N/A","N/A","N/A"]
["Role of IL-17A in Psoriasis","N/A","N/A","N/A","N/A"]
["CSDE1 Signaling Pathway","N/A","N/A","N/A","N/A"]
["iNOS Signaling","N/A","N/A","N/A","N/A"]
["BEX2 Signaling Pathway","N/A","N/A","N/A","N/A"]
["GP6 Signaling Pathway","N/A","N/A","N/A","N/A"]
["Toll-like Receptor Cascades","N/A","N/A","N/A","N/A"]
["Role of OCT4 in Mammalian Embryonic Stem Cell Pluripotency","N/A","N/A","N/A","N/A"]
["Hepatic Fibrosis / Hepatic Stellate Cell Activation","N/A","N/A","N/A","N/A"]
["Erythropoietin Signaling Pathway","N/A","N/A","N/A",0]
["Dolichyl-diphosphooligosaccharide Biosynthesis","N/A","N/A","N/A","N/A"]
["Differential Regulation of Cytokine Production in Macrophages and T Helper Cells by IL-17A and IL-17F","N/A","N/A","N/A","N/A"]
["NAD biosynthesis II (from tryptophan)","N/A","N/A","N/A","N/A"]
["Superoxide Radicals Degradation","N/A","N/A","N/A","N/A"]
["Synaptogenesis Signaling Pathway","N/A","N/A","N/A",0]
["Cytosolic sensors of pathogen-associated DNA","N/A","N/A","N/A","N/A"]
["Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis","N/A","N/A","N/A","N/A"]
["Gαq Signaling","N/A","N/A","N/A","N/A"]
["Amyotrophic Lateral Sclerosis Signaling","N/A","N/A","N/A","N/A"]
["Inhibition of Angiogenesis by TSP1","N/A","N/A","N/A","N/A"]
["Glutathione Redox Reactions I","N/A","N/A","N/A","N/A"]
["FOXO-mediated transcription of cell cycle genes","N/A","N/A","N/A","N/A"]
["MIF Regulation of Innate Immunity","N/A","N/A","N/A","N/A"]
["Granulocyte Adhesion and Diapedesis","N/A","N/A","N/A","N/A"]
["Plasma lipoprotein assembly, remodeling, and clearance","N/A","N/A","N/A","N/A"]
["Response to elevated platelet cytosolic Ca2+","N/A","N/A","N/A","N/A"]
["Insulin Receptor Signaling","N/A","N/A","N/A","N/A"]
["Syndecan interactions","N/A","N/A","N/A","N/A"]
["TREM1 Signaling","N/A","N/A","N/A","N/A"]
["ATF4 activates genes in response to endoplasmic reticulum stress","N/A","N/A","N/A","N/A"]
["Integration of energy metabolism","N/A","N/A","N/A","N/A"]
["ATM Signaling","N/A","N/A","N/A","N/A"]
["Sirtuin Signaling Pathway","N/A","N/A","N/A","N/A"]
["Agranulocyte Adhesion and Diapedesis","N/A","N/A","N/A","N/A"]
["Airway Pathology in Chronic Obstructive Pulmonary Disease","N/A","N/A","N/A","N/A"]
["Interleukin-4 and Interleukin-13 signaling","N/A","N/A","N/A","N/A"]
["NLR signaling pathways","N/A","N/A","N/A","N/A"]
["Sumoylation Pathway","N/A","N/A","N/A","N/A"]
["Glioma Invasiveness Signaling","N/A","N/A","N/A",0]
["Clathrin-mediated Endocytosis Signaling","N/A","N/A","N/A","N/A"]
["Caspase activation via Death Receptors in the presence of ligand","N/A","N/A","N/A","N/A"]
["Reelin signalling pathway","N/A","N/A","N/A","N/A"]
["Interferon gamma signaling","N/A","N/A","N/A","N/A"]
["Transport of vitamins, nucleosides, and related molecules","N/A","N/A","N/A","N/A"]
["NAD Biosynthesis from 2-amino-3-carboxymuconate Semialdehyde","N/A","N/A","N/A","N/A"]
["CD40 Signaling","N/A","N/A","N/A","N/A"]
["DDX58/IFIH1-mediated induction of interferon-alpha/beta","N/A","N/A","N/A","N/A"]
["Superpathway of Citrulline Metabolism","N/A","N/A","N/A","N/A"]
["Xenobiotic Metabolism AHR Signaling Pathway","N/A","N/A","N/A","N/A"]
["γ-glutamyl Cycle","N/A","N/A","N/A","N/A"]
["RANK Signaling in Osteoclasts","N/A","N/A","N/A","N/A"]
["WNT/β-catenin Signaling","N/A","N/A","N/A","N/A"]
["Coagulation System","N/A","N/A","N/A","N/A"]
["Reversible hydration of carbon dioxide","N/A","N/A","N/A","N/A"]
["G alpha (s) signalling events","N/A","N/A","N/A","N/A"]
["Salvage Pathways of Pyrimidine Deoxyribonucleotides","N/A","N/A","N/A","N/A"]
["ERB2-ERBB3 Signaling","N/A","N/A","N/A","N/A"]
["Glutathione Redox Reactions II","N/A","N/A","N/A","N/A"]
["Class B/2 (Secretin family receptors)","N/A","N/A","N/A","N/A"]
["MyD88:MAL(TIRAP) cascade initiated on plasma membrane","N/A","N/A","N/A","N/A"]
["Oncostatin M Signaling","N/A","N/A","N/A","N/A"]
["SUMOylation of immune response proteins","N/A","N/A","N/A","N/A"]
["Iron homeostasis signaling pathway","N/A","N/A","N/A","N/A"]
["EPH-Ephrin signaling","N/A","N/A","N/A","N/A"]
["trans-Golgi Network Vesicle Budding","N/A","N/A","N/A","N/A"]
["Polyamine Regulation in Colon Cancer","N/A","N/A","N/A","N/A"]
["PPARα/RXRα Activation","N/A","N/A","N/A","N/A"]
["Azathioprine ADME","N/A","N/A","N/A","N/A"]
["Detoxification of Reactive Oxygen Species","N/A","N/A","N/A","N/A"]
["Activation of IRF by Cytosolic Pattern Recognition Receptors","N/A","N/A","N/A","N/A"]
["Activation of Matrix Metalloproteinases","N/A","N/A","N/A","N/A"]
["Arachidonic acid metabolism","N/A","N/A","N/A","N/A"]
["LPS-stimulated MAPK Signaling","N/A","N/A","N/A","N/A"]
["Semaphorin Signaling in Neurons","N/A","N/A","N/A","N/A"]
["TAK1-dependent IKK and NF-kappa-B activation","N/A","N/A","N/A","N/A"]
["Salvage Pathways of Pyrimidine Ribonucleotides","N/A","N/A","N/A","N/A"]
["Urea Cycle","N/A","N/A","N/A","N/A"]
["NR1H2 and NR1H3-mediated signaling","N/A","N/A","N/A","N/A"]
["Death Receptor Signaling","N/A","N/A","N/A","N/A"]
["Reelin Signaling in Neurons","N/A","N/A","N/A","N/A"]
["Role of Hypercytokinemia/hyperchemokinemia in the Pathogenesis of Influenza","N/A","N/A","N/A","N/A"]
["BMAL1:CLOCK,NPAS2 activates circadian gene expression","N/A","N/A","N/A","N/A"]
["Vitamin D (calciferol) metabolism","N/A","N/A","N/A","N/A"]
["Serine biosynthesis","N/A","N/A","N/A","N/A"]
["Signaling by PDGF","N/A","N/A","N/A","N/A"]
["Collagen biosynthesis and modifying enzymes","N/A","N/A","N/A","N/A"]
["Role of IL-17A in Arthritis","N/A","N/A","N/A","N/A"]
["TNFR1 Signaling","N/A","N/A","N/A","N/A"]
["Spermine and Spermidine Degradation I","N/A","N/A","N/A","N/A"]
["TWEAK Signaling","N/A","N/A","N/A","N/A"]
["Role of MAPK Signaling in Inhibiting the Pathogenesis of Influenza","N/A","N/A","N/A","N/A"]
["MyD88 dependent cascade initiated on endosome","N/A","N/A","N/A","N/A"]
["Axonal Guidance Signaling","N/A","N/A","N/A","N/A"]
["Nucleotide salvage","N/A","N/A","N/A","N/A"]
["1,25-dihydroxyvitamin D3 Biosynthesis","N/A","N/A","N/A","N/A"]
["Induction of Apoptosis by HIV1","N/A","N/A","N/A","N/A"]
["PI3K/AKT Signaling","N/A","N/A","N/A","N/A"]
["Citrulline Biosynthesis","N/A","N/A","N/A","N/A"]
["p53 Signaling","N/A","N/A","N/A","N/A"]
["Sertoli Cell-Germ Cell Junction Signaling Pathway (Enhanced)","N/A","N/A","N/A",0]
["FAT10 Cancer Signaling Pathway","N/A","N/A","N/A","N/A"]
["Assembly of collagen fibrils and other multimeric structures","N/A","N/A","N/A","N/A"]
["Transport of bile salts and organic acids, metal ions and amine compounds","N/A","N/A","N/A","N/A"]
["RHO GTPases Activate NADPH Oxidases","N/A","N/A","N/A","N/A"]
["Toll Like Receptor 3 (TLR3) Cascade","N/A","N/A","N/A","N/A"]
["Pexophagy","N/A","N/A","N/A","N/A"]
["Glutathione Biosynthesis","N/A","N/A","N/A","N/A"]
["Urea cycle","N/A","N/A","N/A","N/A"]
["Toll-like Receptor Signaling","N/A","N/A","N/A","N/A"]
["TNFR2 non-canonical NF-kB pathway","N/A","N/A","N/A","N/A"]
["Apoptosis Signaling","N/A","N/A","N/A","N/A"]
["Superpathway of Serine and Glycine Biosynthesis I","N/A","N/A","N/A","N/A"]
["Serine Biosynthesis","N/A","N/A","N/A","N/A"]
["IL-13 Signaling Pathway","N/A","N/A","N/A","N/A"]
["MyD88-independent TLR4 cascade","N/A","N/A","N/A","N/A"]
["TNF signaling","N/A","N/A","N/A","N/A"]
["WNT/SHH Axonal Guidance Signaling Pathway","N/A","N/A","N/A","N/A"]
["Signaling by NTRK1 (TRKA)","N/A","N/A","N/A","N/A"]
["Ephrin A Signaling","N/A","N/A","N/A","N/A"]
["NGF-stimulated transcription","N/A","N/A","N/A","N/A"]
["DNA Damage/Telomere Stress Induced Senescence","N/A","N/A","N/A","N/A"]
["MIF-mediated Glucocorticoid Regulation","N/A","N/A","N/A","N/A"]
["NCAM signaling for neurite out-growth","N/A","N/A","N/A","N/A"]
["Acetyl-CoA Biosynthesis III (from Citrate)","N/A","N/A","N/A","N/A"]
["Production of Nitric Oxide and Reactive Oxygen Species in Macrophages","N/A","N/A",0,0]
["TNFR2 Signaling","N/A","N/A","N/A","N/A"]
["HER-2 Signaling in Breast Cancer","N/A","N/A","N/A","N/A"]
["Role of Tissue Factor in Cancer","N/A","N/A","N/A","N/A"]
["Fatty acyl-CoA biosynthesis","N/A","N/A","N/A","N/A"]
["Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer","N/A","N/A","N/A","N/A"]
["Trafficking and processing of endosomal TLR","N/A","N/A","N/A","N/A"]
["Role of JAK2 in Hormone-like Cytokine Signaling","N/A","N/A","N/A","N/A"]
["PEDF Signaling","N/A","N/A","N/A","N/A"]
["VDR/RXR Activation","N/A","N/A","N/A","N/A"]
["Macrophage Classical Activation Signaling Pathway","N/A","N/A","N/A","N/A"]
["Ribonucleotide Reductase Signaling Pathway","N/A","N/A","N/A","N/A"]
["Collagen chain trimerization","N/A","N/A","N/A","N/A"]
["Interleukin-6 family signaling","N/A","N/A","N/A","N/A"]
["Angiopoietin Signaling","N/A","N/A","N/A","N/A"]
["HEY1 Signaling Pathway","N/A","N/A","N/A","N/A"]
["Regulation of TLR by endogenous ligand","N/A","N/A","N/A","N/A"]
["IL-17A Signaling in Airway Cells","N/A","N/A","N/A","N/A"]
["Ferroptosis Signaling Pathway","N/A","N/A","N/A","N/A"]
["RAF-independent MAPK1/3 activation","N/A","N/A","N/A","N/A"]
["RIPK1-mediated regulated necrosis","N/A","N/A","N/A","N/A"]
["IL-8 Signaling","N/A","N/A","N/A","N/A"]
["IL-6 Signaling","N/A","N/A","N/A","N/A"]
["Role of IL-17F in Allergic Inflammatory Airway Diseases","N/A","N/A","N/A","N/A"]
["Glucocorticoid Receptor Signaling","N/A","N/A","N/A","N/A"]
["RHOGDI Signaling","N/A","N/A","N/A","N/A"]
["Semaphorin interactions","N/A","N/A","N/A","N/A"]
["Arginine Degradation I (Arginase Pathway)","N/A","N/A","N/A","N/A"]
["Transcriptional regulation of pluripotent stem cells","N/A","N/A","N/A","N/A"]
["Intrinsic Prothrombin Activation Pathway","N/A","N/A","N/A","N/A"]
["Dissolution of Fibrin Clot","N/A","N/A","N/A","N/A"]
["Advanced glycosylation endproduct receptor signaling","N/A","N/A","N/A","N/A"]
["NRF2-mediated Oxidative Stress Response","N/A","N/A","N/A","N/A"]
["Ovarian Cancer Signaling","N/A","N/A","N/A","N/A"]
["ROBO SLIT Signaling Pathway","N/A","N/A","N/A","N/A"]
["Cell junction organization","N/A","N/A","N/A","N/A"]